Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-12-31

Good afternoon,

As a reminder, we will not be completing the Daily Scan on January 1^st.

There are 257 citations in today’s scan. 157 were considered primary research or review literature.

Highlights today include:

EPIDEMIOLOGY

· Hanrath et al. in a letter to the editor describe COVID-19 infection results among HCWs in the UK and show the epidemiological data suggests HCWs infected early in the epidemic have had short term protection against re-infection in the fall. A positive PCR test was returned in 0/1038 (0%) of those with previous infection in the spring, compared to 290/10,137 (2.9%) of those that were not infected in the spring.

CORONAVIROLOGY

· Rubsamen et al study SARs-CoV-2 mutations in infected mink populations. The viral genomic mutations in minks observed in the Netherlands and Denmark show the potential for new mutations on the SARS-CoV-2 spike protein RBD to be introduced into humans by zoonotic transfer. Our data suggests that close attention to viral transfer from humans to farm animals and pets will be required to prevent build-up of a viral reservoir for future zoonotic transfer.

IMMUNOLOGY

· Veesler et al. in this preprint, reports on the isolation of a monoclonal antibody, termed B6, that cross-reacts with eight β-coronavirus spike glycoproteins, including all five human-infecting β-coronaviruses, and broadly inhibiting entry of pseudotyped viruses from two coronavirus lineages. The data provide a structural framework explaining B6 cross-reactivity with β-coronaviruses from three lineages along with proof-of-concept for antibody-mediated broad coronavirus neutralization elicited through vaccination.

THERAPEUTICS

· Cadegiani et al conducted a randomized double-blinded placebo-controlled trial of proxalutamide for the treatment men with ambulatory mild COVID-19 disease. Men with ambulatory mild COVID-19 disease receiving anti-androgen treatment with proxalutamide, had significantly reduced rate of hospitalization compared to men not receiving anti-androgen treatment.

Regards,

Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley Otten, Drew Greydanus, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark, Catherine Card, Ruey Su, Paul McLaren, Sandra Kiazyk, Nana Amankwah

Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news

Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance, Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI, Réponse des soins de santé, Immunologie, économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux

PUBLICATIONS	AUTHORS / AUTEURS	SOURCE	FOCI / DOMAINE	SUMMARY / SOMMAIRE
Cardiovascular complications in COVID-19 patients with or without diabetes mellitus	Abe,  T,  Egbuche, et al	Endocrinology, Diabetes and Metabolism	Epidemiology| Épidémiologie Clinical data| Données cliniques	We included 142 patients admitted with laboratory-confirmed COVID-19 from April 1st to May 30th 2020; 71 (50%) had diabetes mellitus (DM). After controlling for relevant confounding variables, diabetic patients had higher odds of composite cardiovascular end-point, acute heart failure and new-onset atrial fibrillation.
Venous thrombosis in a systemic lupus erythematosus patient with antiphospholipid antibodies coinciding with mild Covid-19	Aguirre-Alastuey,  M,  Suárez-Díaz, et al	Lupus	Clinical data| Données cliniques	We present a case of a young female (22 yo) with a history of SLE and aPL antibodies, who  developed pulmonary thromboembolism coinciding with SARS-CoV-2 infection.
VGG-CovidNet: A Bi-Branched Dilated Convolutional Neural Network for Detection of COVID-19 Cases from Chest X-Ray Images	Albahar,  Marwan,  Binsawad, et al	Research Square prepub	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	This study introduces a dilated bi-branched convoluted neural network (CNN) architecture called VGG-COVIDNet, tailored to detect COVID-19 cases from chest X-ray (CXR) images. The simulation results show that the proposed architecture yielded the highest accuracy and produced the highest sensitivity compared to state-of-the-art architectures. The proposed architecture’s accuracy and sensitivity are 96.5% and 96%, respectively, for each of the infection types.
PMC7768269; Venous Doppler ultrasound in critically Ill COVID-19 patients: game changer in anticoagulation therapy	Alfageme,  M,  González Plaza, et al	Ultrasound J	Clinical data| Données cliniques	The purpose of our retrospective study was to evaluate the prevalence of asymptomatic deep vein thrombosis (DVT) in lower limbs in critically ill COVID-19 patients (n = 23) with severe respiratory failure and high levels of D-dimer by bedside Doppler ultrasound (DU). In critically COVID-19 ill ICU patients with severe respiratory failure and elevated D-dimer, the incidence of asymptomatic DVT is high.
Intention and practice on personal preventive measures against the covid-19 pandemic among adults with chronic conditions in southern ethiopia: A survey using the theory of planned behavior	Andarge,  E,  Fikadu, et al	Journal of Multidisciplinary Healthcare	Public Health response| Interventions de santé publique	This study assessed the intention to practice and practice on personal preventive measures (PPMs) among adults with chronic conditions. The study showed that 52% (95% CI=47.61–54.80) and 76.3% (95% CI=73.36– 79.24) of adults with chronic conditions were intending to practice and had ever practiced the personal preventive measures. Participants’ subjective norm (SN) (AOR=4.94; 95% CI=3.49–6.96) and perceived behavioral control (PBC) (AOR=4.13; 95% CI=2.69–6.34) were the factors associated with their intention. Good knowledge and a positive attitude were found to be significant factors associated with the participants’ actual practice of the PPMs among other independent factors.
The gender differences as a risk factor in diabetic patients with covid-19	Belice,  T,  Demir, et al	Iranian Journal of Microbiology	Epidemiology| Épidémiologie Clinical data| Données cliniques	The demographics, length of stay, mortality rates and concomitant chronic metabolic diseases of 152 patients diagnosed with COVID-19 were found in our hospital electronic document system.  In the mortality group (n:22), the numbers of men and women were 9 (40.9%) and 4 (18.2%), respectively. Comparing gender rates in diabetic group, the mortality risk of diabetic men was higher and statistically significant (p<0.05, Pearson Chi-square value:7.246).
Susceptibility of turkeys, chickens and chicken embryos to SARS-CoV-2	Berhane,  Y,  Suderman, et al	Transbound Emerg Dis	Transmission Animal model | Modèle animal	The susceptibility of turkeys, chickens and chicken embryos to SARS-CoV-2 was evaluated by experimental infection.  Turkeys and chickens were inoculated using a combination of intranasal, oral and ocular routes. Both turkeys and chickens did not develop clinical disease or seroconvert following inoculation. Viral RNA was not detected in oral swabs, cloacal swabs or in tissues using quantitative real-time RT-PCR. In addition, chicken embryos were inoculated by various routes including; the yolk sac, intravenous, chorioallantoic membrane and allantoic cavity. In all instances, chicken embryos failed to support replication of the virus. SARS-CoV-2 does not affect turkeys or chickens in the current genetic state and does not pose any potential risk to establish an infection in both species of domestic poultry.
Gallium maltolate has in vitro antiviral activity against SARS-CoV-2 and is a potential treatment for COVID-19	Bernstein,  LR,  Zhang, et al	Antiviral Chemistry and Chemotherapy	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	In this study, we assessed the ability of GaM to inhibit the replication of SARS-CoV-2 in a culture of Vero E6 cells. The results showed that GaM inhibits viral replication in a dose-dependent manner, with the concentration that inhibits replication by 50% (EC50) being about 14 µM. No cytotoxicity was observed at concentrations up to at least 200 µM. The in vitro activity of GaM against SARS-CoV-2, together with GaM’s known anti-inflammatory activity, provide justification for testing GaM in COVID-19 patients.
Awareness and perception towards various principles of lockdown and dental practice during covid 19 pandemic among general population	Bipin,  M,  Sangeetha, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	The present study is a cross sectional survey conducted among 101 general populations to analyze their knowledge and awareness of the principles of lockdown. Results showed that 73.8% of the study population was aware of the lockdown and 45.6% of the study population obeys the lockdown regulations.
Assessment of Neutrophil Extracellular Traps in Coronary Thrombus of a Case Series of Patients With COVID-19 and Myocardial Infarction	Blasco,  A,  Coronado, et al	JAMA Cardiol	Clinical data| Données cliniques	This study aimed to determine the role of neutrophil extracellular traps (NETs) in coronary thrombosis in patients with COVID-19. In this small case series of patients with COVID-19 and myocardial infarction, NETs seem to play a major role in the pathogenesis of STEMI in COVID-19 disease. Our findings support the idea that targeting intravascular NETs might be a relevant goal of treatment and a feasible way to prevent coronary thrombosis in patients with severe COVID-19 disease.
Transmission of SARS-CoV-2 in surgical smoke during laparoscopy: a prospective, proof-of-concept study	Bogani,  G,  Ditto, et al	J Minim Invasive Gynecol	Transmission Healthcare Response | Réponse des soins de santé	Here, we aimed to investigate the presence SARS-CoV-2 through surgical smoke. Our study suggested the proof of principle that SARS-CoV-2 might be transmitted through the surgical smoke and aerosolized native fluid from the abdominal cavity.
Sars-cov-2 rapid detection system using electric current-spectrum for human exhaled air samples	Bqoor,  M,  Albqoor, et al	Electronic Journal of General Medicine	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The SARS-COV-2 Rapid Detection System is a SARS-COV-2 Electro-Spectroscopy detection system. The preliminary design of this system was studied theoretically in this paper. This system can detect the existence of sub-micro impurity particles in the human exhaled air, based on the unique shape, dimensions and density of these sub-micro impurities, such as viral particles, including CORONA viruses.
Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence	Bullen,  Georgia,  Galson, et al	bioRxiv	Clinical data| Données cliniques Immunology | Immunologie	Here, we describe deep-mining of the antibody repertoires of hospitalised COVID-19 patients using a combination of phage display technology and B cell receptor (BCR) repertoire sequencing to isolate neutralising antibodies and gain insights into the early antibody response. This comprehensive discovery approach has yielded potent neutralising antibodies with distinct mechanisms of action, including the identification of a novel non-ACE2 receptor blocking antibody that is not expected to be affected by any of the major viral variants reported. The study highlighted the presence of potent neutralising antibodies with near germline sequences within both the IgG and IgM pools at early stages of infection.
Proxalutamide (GT0918) Reduces the Rate of Hospitalization and Death in COVID-19 Male Patients: A Randomized Double-Blinded Placebo-Controlled Trial	Cadegiani,  Flavio Adsuara,  McCoy, et al	Research Square prepub	Clinical data| Données cliniques Therapeutics| Thérapeutique RCT	This RCT aimed to determine if the anti-androgen proxalutimide is an effective treatment for men with ambulatory mild COVID-19 disease. Men with ambulatory mild COVID-19 disease (WHO ordinal scale ≤3) receiving anti-androgen treatment with proxalutamide, had significantly reduced rate of hospitalization compared to men not receiving anti-androgen treatment.
In Vitro Safety “Clinical Trial” of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy	Charrez,  Bérénice,  Charwat, et al	bioRxiv	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Here we report on a preclinical drug screening platform, a cardiac microphysiological system (MPS), to assess cardiotoxicity associated with hydroxychloroquine (HCQ) and azithromycin (AZM) polytherapy in a mock clinical trial. Upon chronic exposure to HCQ and AZM polytherapy, we observed an increase in QT interval on days 4-8. Interestingly, a decrease in arrhythmias and instabilities was observed in polytherapy relative to monotherapy, in concordance with published clinical trials. Furthermore, biomarkers, most of them measurable in patients’ serum, were identified for negative effects of single drug or polytherapy on tissue contractile function, morphology, and antioxidant protection.
Risk of COVID-19 Transmission from Infected Outpatients to Healthcare Workers in an Outpatient Clinic	Chung,  H,  Kim, et al	J Korean Med Sci	Epidemiology| Épidémiologie Transmission	From January to September 2020, we conducted contact-tracing for confirmed COVID-19 patients who visited our outpatient clinic to evaluate the risk of COVID-19 transmission from infected patients to healthcare workers (HCWs). COVID-19 was diagnosed in 8 outpatients. None of the 317 HCWs who came in contact had a confirmed COVID-19 diagnosis. This low rate of transmission from infected outpatients to HCWs suggests that standard precaution such as using surgical mask and hand hygiene protects HCWs from SARS-CoV-2 in a low-risk, outpatient clinic setting.
Experiences and psychological adjustments of nurses who voluntarily supported covid-19 patients in Hubei Province, China	Cui,  S,  Zhang, et al	Psychology Research and Behavior Management	Mental Health | santé mentale Healthcare Response | Réponse des soins de santé	This qualitative study aimed at exploring the experiences and psychological adjustments of nurses who voluntarily traveled to Hubei Province in China to provide support during the COVID-19 epidemic. The following themes emerged from the analysis: (1) motivations for supporting the hardest-hit areas; (2) challenges faced during the support missions (heavy workloads, changes in working patterns, communication barriers, and barriers associated with wearing personal protective equipment); (3) psychological experiences (a sense of uncertainty, fear of infection, loneliness, stressful events, and sleep disorders); (4) psychological adjustments (adequate training and personal protective equipment, positive responses to stress, and social support); and (5) personal and professional growth.
Severe SARS-CoV-2 patients develop a higher specific T-cell response	Demaret,  J,  Lefèvre, et al	Clinical and Translational Immunology	Clinical data| Données cliniques Immunology | Immunologie	Assessment of the adaptive immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)- the study demonstrates that SARS-CoV-2 patients developing a severe disease achieve a higher adaptive immune response. . We quantified IFNγ-secreting T cells reactive against the main viral SARS-CoV-2 antigens using ELISpot.  Specific T cells were assessed in 60 consecutive patients (mild, n = 26; moderate, n = 10; and severe patients, n = 24) during their follow-up 36 days 28-53. T cells against M, N and S peptide pools were detected in n = 60 (100%), n = 56 (93.3%), n = 55 patients (91.7%), respectively. Using the MNS mix, IFNγ T-CoV-Spot assay showed a specificity of 96.7% (95% CI, 88.5–99.6%) and a specificity of 90.3% (75.2–98.0%). The frequency of reactive T cells observed with M, S and MNS mix pools correlated with severity and with levels of anti-S1 and anti-RBD serum antibodies.
Perception and awareness of covid-19 among urban and rural population – a survey	Dhayanithi,  J,  Balaji Ganesh, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	India, public perception and knowledge survey.  n=100 from urban 53% and rural 47% areas.  66% of participants accept that urban populations are more prone to the spread of coronavirus infection than the urban population. 60% of participants agree that both urban and rural people are aware of coronavirus. 65% of participants say that COVID-19 spread occurs due to droplet transmission and touching objects used by infected patients. 65% of participants say that mouth mask, handwash, and social isolation protects from the transmission of infection.  According to the study, rural people are less aware of Covid-19 than urban people.
Age Based Modelling of SARS-CoV-2 Contagion: The Italian case	Di Giamberardino,  P,  Iacoviello, et al		Modelling/ prediction| Modélisation/prédiction	Italy,  SEIQR model was developed with full age assignments based on Italian statistics.  They only describe the model and its fit to the Italian epidemic up to end of June.
Awareness on the role of health care workers in covid-19-need of the hour	Divya Sri,  E,  Vishnu Priya, et al	International Journal of Current Research and Review	Healthcare Response | Réponse des soins de santé	Self-administered questionnaire on the awareness of COVID-19 among healthcare professionals were prepared. We have observed that the association between gender and responses to awareness on methods awareness of diagnostic tests for COVID-19 was statistically significant (p = 0.002). There is a need for regular educational awareness programs and training programs on infection control practices for COVID-19 across all healthcare professionals. Thus, minimize the risk of transmission to healthcare workers and provide optimal care for patients.
Association of Health Status and Smoking Behaviors with SARS-CoV-2 Positivity Rates	Duszynski,  Thomas,  Fadel, et al	Research Square prepub	Epidemiology| Épidémiologie	Two community-based population samples (including individuals randomly and nonrandomly selected for statewide testing, n= 8,214) underwent SARS-CoV-2 testing in nonclinical settings. Each participant was tested for current (viral PCR) and past (antibody) infection in April or June of 2020.  Compared to people with self-identified “excellent” or very good health status, those reporting “good” or “fair” health status had a higher risk of past or current infections. Positive smoking status was inversely associated with SARS-CoV-2 infection. Chewing tobacco was associated with infection and the use of vaping/e-cigarettes was not associated with infection.
A case series of ischemic stroke with coronavirus disease 2019 in two Egyptian centers	El Nahas,  N,  Roushdy, et al	Egyptian Journal of Neurology, Psychiatry and Neurosurgery	Clinical data| Données cliniques	Case series, Egypt:  We are presenting 10 cases with cerebrovascular manifestations after having COVID-19 few days prior to stroke.
Predictors of hospital-acquired bacterial and fungal superinfections in COVID-19: a prospective observational study	Falcone,  M,  Tiseo, et al	J Antimicrob Chemother	Epidemiology| Épidémiologie Clinical data| Données cliniques	Italy: Prospective, observational study including patients with COVID-19 consecutively admitted to the University Hospital of Pisa, Italy, between 4 March and 30 April 2020, Superinfection was defined as a bacterial or fungal infection that occurred ≥48 h after hospital admission.  315 patients with COVID-19 were hospitalized and 109 episodes of superinfections were documented in 69 (21.9%) patients. Superinfections were caused by Enterobacterales (44.9%), non-fermenting Gram-negative bacilli (15.6%), Gram-positive bacteria (15.6%) and fungi (5.5%). Polymicrobial infections accounted for 18.3%. Predictors of superinfections were: intestinal colonization by carbapenem-resistant Enterobacterales (OR 16.03, 95% CI 6.5-39.5, P 7 mg/dl (OR 3.59, 95% CI 1.7-7.7, P = 0.001); and previous treatment with piperacillin/tazobactam (OR 2.85, 95% CI 1.1-7.2, P = 0.028).
The Social Amplification of Risk on Weibo-Take the COVID-19 Epidemic in China as an Example	Fan,  Y		Public Health response| Interventions de santé publique	In this paper, 4447 COVID-19 trending hash-tags on Weibo are filtered through statistics software and manual scrutinization, and analyzed the volume and content of the COVID-19 topic. This research aims to explore the process of COVID-19 risk amplified on Weibo. The following conclusions are drawn: The changes of the focus on the public risk on Weibo accord with the development of the epidemic. COVID-19 has encountered an appropriate social amplification effect by controlling dramatic information, controversial topics, as well as social and cultural influences.
Active tobacco smoking is associated with lower risk of acquiring SARS-CoV-2 infection among people living with HIV	Fernandez-Fuertes,  Marta	Research Square prepub	Epidemiology| Épidémiologie	Spain: Retrospective nested case-control study performed within a cohort of 702 people living with human immunodeficiency virus (PLWH) Feb-Oct 2020.  Cases 18/ controls 684.  Exposure: Active tobacco smoking vs. non-smoking, using self-reported electronic health record data.  Three hundred and sixty-nine (52.6%) individuals were active smokers, 2 (11.1%) at the COVID-19 diagnosis and 367 (54.1%) in control group (p=0.001). Multivariate analysis, adjusted by sex, tobacco smoking and Charlson index, showed that tobacco smoking was independently related to a higher probability of SARS-CoV2 infection aOR=9.42 (95% CI 2.15-41.33), p = 0.003].
Defective NETs Clearance contributes to sustained FXII Activation in COVID-19-associated Pulmonary Thrombo-Inflammation	Frye,  Maike,  Englert, et al	bioRxiv	Clinical data| Données cliniques	Coagulopathy and inflammation are hallmarks of Coronavirus disease 2019 (COVID-19) and are associated with increased mortality.  Here, we report a role of the NETs/ Factor XII (FXII) axis for initiating procoagulant and proinflammatory reactions in COVID-19.  We further showed that an accumulation of NETs is partially caused by impaired NETs clearance via extracellular DNases.
Environmental Dependence of the Structure of the C-terminal Domain of the SARS-CoV-2 Envelope Protein	Gadhave,  Kundlik,  Kumar, et al	bioRxiv	Coronavirology| Coronavirologie	The SARS-CoV-2 envelope protein (E) is involved in a broad spectrum of functions in the cycle of the virus, including assembly, budding, envelope formation, and pathogenesis. The findings indicate that the E-CTD can change its conformation depending on its environment, ranging from a disordered state, to a membrane-bound folded state, and an amyloid state. Our results thus provide insight into the structural basis of the role of E in the viral infection process.
Awareness on dental treatment during covid-19 among south indian population	Ganesh,  S,  Vishnu Priya, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	India: 100 participants in a 15q survey about dental proceedures and COVID risks. 87.13% were aware of the risk of spread involved during dental treatment (Fig. 4). 44.55% for contact, 22.77% for water during the procedure, and 32.67% for the saliva were responses for the mode of spread of COVID-19. Knowledge gaps are described among some segments of the population.
Data driven characterization of COVID-19	Giamberardino,  PD,  Iacoviello, et al		Modelling/ prediction| Modélisation/prédiction	Italy, SEIRD model looking at the spread of the epidemic in Italy.  based on available data, variation across regions in Italy are not fully explained, future work will be to refine this model.
An institutional based study on imaging conundrum of newly diagnosed coronavirus disease 2019 (Covid-19) – a retrospective analysis in India population	Goel,  V,  Goyal, et al	International Journal of Current Research and Review	Clinical data| Données cliniques	India, A retrospective single-centre study was conducted on patients with COVID-19 from May 10, 2020, to July 13, 2020, Retrospectively characterize and interpret the spectrum of chest computed tomography (CT) imaging features of COVID-19 and to correlate CT total severity score with clinical classification and study extra-pulmonary manifestation (n=522).  According to the clinical subtype classification there were mild 17 (3.3%), common 355 (68.0%), severe 105 (20.1%) and critical 45 (8.6%) cases. 57 (10.9%) patients died and 37 (7.08%) patients showed extra-pulmonary manifestation of COVID-19.  Proportion of patients 17 (3.2%)] with normal CT chest in laboratory-confirmed COVID-19 was relatively low; hence chest CT may play a complementary role in the early detection of COVID-19 pneumonia and could be regarded as a diagnotic standard of COVID-19.
A case of COVID-19 with multiple cranial neuropathies	Gogia,  B,  Gil, et al	Int J Neurosci	Clinical data| Données cliniques	Case report:  This is a case of COVID-19 with ipsilateral fifth and seventh cranial nerve involvement with complete resolution of symptoms over a period of 3 weeks. The neurological symptoms started within 5 days of respiratory symptoms. We conclude that isolated cranial neuropathies can be the manifestations of SARS-CoV-2 infection.
Comparison of Hospitalized Patients with Severe Pneumonia Caused by COVID-19 and Highly Pathogenic Avian Influenza (H7N9): A Retrospective Study from A Designated Hospita	Gu,  Binbin,  Yao, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques	China: The clinical data of 23 cases of H7N9 (influenza) and 23 cases of COVID-19 with severe pneumonia were collected. Radiologically, severe COVID-19 patients had less consolidation and pleural effusion, but more crazy-paving pattern than severe H7N9 patients (p<0.05).  Although more severe H7N9 patients needed non-invasive respiratory support, these two groups ultimately yielded comparable mortality. Based on multiple logistic regression analysis, severe COVID-19 infection was associated with a lower risk of the presence of severe ARDS (OR 0.964, 95% CI] 0.931-0.998, p=0.040), but exhibited longer duration of viral shedding (OR 0.734, 95% CI] 0.550-0.980, p=0.036) than severe H7N9 infection.
A randomized, multicenter, open-label, adaptive, proof of concept clinical trial of new antivirals working against Sars-CoV2: Direct Antivirals Working against the Novel coronavirus – Azithromycin (DAWn-AZITHRO) trial	Gyselinck,  Iwein,  Liesenborghs, et al	Research Square prepub	RCT	Protocol - DAWn-Azithro is a randomized, open-label, phase 2 proof-of-concept, multicenter clinical trial, evaluating the safety and efficacy of azithromycin for treating hospitalized patients with COVID-19.
Prior SARS-CoV-2 infection is associated with protection against symptomatic reinfection	Hanrath,  AT,  Payne, et al	J Infect	Epidemiology| Épidémiologie Immunology | Immunologie	UK: SARS-CoV-2 infection appears to result in protection against symptomatic infection in working age adults, at least in the short term. 11 000 HCW with exposure in the first wave (Mar10-Jul6 2020).  Second wave (Jul7-Nov20 2020) was analyzed to see if exposure during the first wave conferred immunity in the second wave among HCWs. Wave 1: 481/3,338  RT-PCR positive and symptomatic &  937/11,103 (8.4%) HCWs were IgG +ve, thus 1038+ve/10137-ve after the first wave--> analysis indicates no significant differences in age or gender, but differences in previous positivity rates according to ethnicity and multiple deprivation indexes.  Second wave: 2243 HCWs were PCR tested.  128 were positive in 1st wave and 0% (0/128) in second wave. 13.7% (290/2115) of those not tested in the first wave were positive in the second wave.  Considering the population as a whole, a positive PCR test was returned in 0/1038 (0% [95% CI: 0-0.4) of those with previous infection, compared to 290/10,137 (2.9% [95% CI: 2.6-3.2) of those without (P<0.0001 χ2 test).
Awareness among college students towards covid-19 and its effects on the cardiovascular system-a survey	Harini,  M,  Devi, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	India, survey to 100 dental college students assessed knowledge of the impact of COVID-19 on the cardiovascular system.   100% of the participants gave a positive response when asked if they were aware of COVID-16 and its effects although the majority of the study population was not aware of its effects in the cardiovascular system.
The Serial Interval of COVID-19 in Korea: 1,567 Pairs of Symptomatic Cases from Contact Tracing	Hong,  K,  Yum, et al	J Korean Med Sci	Epidemiology| Épidémiologie Transmission	Through the Korean national COVID-19 contact tracing system, we were able to investigate personal contacts in all symptomatic cases in Korea from January 20 to August 3, 2020.   The mean serial interval before and after this fifth case definition was 6.12 and 3.93 days based on the infectors' symptom onset date, respectively, and 4.02 days in total with the median of 3 days. Older age and women lead to longer serial intervals.
Plasma levels of the active form of suPAR are associated with COVID-19 severity	Huang,  M,  Li, et al	Crit Care	Epidemiology| Épidémiologie Clinical data| Données cliniques	In our study, we found that active suPAR levels in all COVID-19 patients were significantly higher than in healthy controls. Strikingly, the active suPAR levels in asymptomatic carriers (8.08 ± 4.81 ng/mL) are not only significantly higher than those in healthy controls but also slightly higher than those in COVID-19 patients. Our data show that active suPAR levels increase as the disease worsens.
Pathomorphological changes of the placenta in pregnant women infected with coronavirus covid-19	Ikhtiyarova,  GA,  Dustova, et al	International Journal of Pharmaceutical Research	Clinical data| Données cliniques	Purpose. To study pathological changes in the placenta in pregnant women infected with the new coronavirus.  Results. All 19 pregnant women diagnosed with COVID-19 infection were in their third trimester of pregnancy and were taken to the hospital for emergency treatment by caesarean section. In all patients, the main symptom was fever without significant leukopenia and lymphopenia. The COVID-19 nucleic acid test was positive in many pregnant women, only a few pregnant women were negative.
SARS-CoV-2 highly conserved s2m element dimerizes via a kissing complex and interacts with host miRNA-1307-3p	Imperatore,  JoshuaA,  Cunningham, et al	bioRxiv	Coronavirology| Coronavirologie	In this study, we demonstrate that the s2m element of SARS-CoV-2 dimerizes by forming an intermediate homodimeric kissing complex structure that is subsequently converted to a thermodynamically stable duplex conformation. This process is aided by the viral nucleocapsid protein, potentially indicating a role in mediating genome dimerization. Furthermore, we demonstrate that the s2m element interacts with multiple copies of host cellular miRNA-1307-3p.
Analysis of public’s opinion towards refugees and curfew periods during covid 19 pandemic-a survey	Imtiaz,  T,  Preetha, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	The main aim of this topic is to collect the opinions of the general population under the age group of 18-60 about refugees and their hardships during curfew periods. 81.4% of the population thought that they don’t have proper access to their necessities and the rest 14.8% thought they do. 91.7% agreed that they will suffer during curfew periods and the rest 8.3% of them disagreed.
Covid implications in dentistry – a questionnaire survey	Iyer,  PK,  Rengalakshmi, et al	International Journal of Current Research and Review	Healthcare Response | Réponse des soins de santé	This study is to check the awareness of the condition among dentists and dental students and to see the effect this disease has bought on dentistry. The aim of this study is to discuss the implications of COVID in dentistry.  60.8% said that COVID spreads through infected aerosols. 57.1% said that they would deny treatment to a patient if they suspect them to be infected with COVID-19. 76.9% feel anxious while treating patients and 82.4% are aware of the authorities to call if they come across a patient suspected with COVID-19.
System wide learning from first wave Covid 19: A realist synthesis of what works?	Jackson,  Carolyn,  Manley, et al	Research Square prepub	Healthcare Response | Réponse des soins de santé	This paper presents a thematic analysis of 176 interview transcripts from front line staff working during the first wave of COVID-19 in the East of England. Four tentative theories of system transformation are presented to highlight support mechanisms that are needed to enable front line teams to be effective in further waves of the pandemic, capitalising on system wide learning, patient, resident and staff wellbeing.
Google knowledge and awareness of covid-19 among the general public-a questionnaire survey	Jaisankar,  AI,  Keerthi Sasanka, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	The aim of the current study is to measure the knowledge and awareness of COVID-19 among the people residing in the locality of Chennai and to provide detailed statistical data. The results show that about 82.57% of the study population had complete knowledge and awareness on the symptoms of the COVID-19 infection and the precautionary measures that help in preventing the infection. The results also show that females have higher knowledge and awareness of the ongoing pandemic than males.
Burnout and Peritraumatic Distress of Healthcare Workers in the COVID-19 Pandemic	Jang,  Yeonhhon,  You, et al	Research Square prepub	Mental Health | santé mentale Healthcare Response | Réponse des soins de santé	The aim was to evaluate the current status of emotional exhaustion and peritraumatic distress of healthcare workers (HCWs) in the COVID-19 pandemic, and identify factors associated with their mental health status. Although no significant difference in peritraumatic distress was observed among the surveyed HCWs, the workers’ experience of emotional exhaustion varied according to work characteristics. Respondents who were female, older, living with a spouse, and/or full-time workers reported higher levels of emotional exhaustion. Public health officers and other medical personnel who did not have direct contact with confirmed patients and full-time workers had a higher level of peritraumatic distress. Forced involvement in work related to COVID-19, worry about stigma, worry about becoming infected, and perceived sufficiency of organizational support negatively predict emotional exhaustion and peritraumatic distress.
The Experience of Australian General Practice Patients at High Risk of Poor Health Outcomes with Telehealth during the COVID-19 Pandemic: A Qualitative Study	Javanparast,  Sara,  Roeger, et al	Research Square prepub	Healthcare Response | Réponse des soins de santé	This study aimed to investigate the experience with telehealth by Australian general practice patients at high risk of poor health outcomes during the COVID-19 pandemic. Participants expressed satisfaction with telehealth including convenient and timely access to general practice services. Yet, participants identified challenges including difficulties in expressing themselves and accessing physical exams. Prescription renewal, discussing test results and simple follow-ups were the most common reasons that telehealth was used.
The index case of COVID-19 in Northeastern Iran	Kalan Farmanfarma,  K,  Moslem, et al	Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace	Clinical data| Données cliniques	The index case of COVID-19 in Sabzevar, Khorasan Razavi Province in northeastern Iran, was an 80-year-old man with a history of psycho-neurological illness and acute respiratory clinical symptoms, and a history of travel to areas with confirmed COVID-19 cases in Gorgan City.
Covid-19 and its psychological impact among general population-a questionnaire survey	Kallivayalil,  JG,  Preetha, et al	International Journal of Current Research and Review	Mental Health | santé mentale Public Health response| Interventions de santé publique	The main aim of the study was to assess the psychological impact and effects due to COVID-19 among the general population.  71.3% of the respondents have heard of the term COVID-19 while 28.7% of the respondents have not heard. 52.5% of the respondents were under stress during this period while 47.5% of the respondents were not under any stress during this period.
Looking for COVID-19 Herd Immunity Through Lotka-Volterra Equations: The São Paulo State (Brazil) Case	Kamimura,  Arlindo,  Sauer, et al	SSRN- Lancet prepublication	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	The Lotka-Volterra equations are applied to understand the phenomenon called Herd Immunity for the case of the COVID-19 epidemic in the state of Sao Paulo (Brazil). N. The different computer rounds with different alpha shows basically the same behavior for I(t), that is, a growth in the beginning until it reaches its peak and then falls asymptotically to zero.
Association between Chronic Kidney Disease or Acute Kidney Injury and Clinical Outcomes in COVID-19 Patients	Kang,  SH,  Kim, et al	J Korean Med Sci	Epidemiology| Épidémiologie Clinical data| Données cliniques	This retrospective study utilized the claim data from Korea. Patients who underwent COVID-19 testing and were confirmed to be positive were included and divided into the following three groups based on the presence of CKD or requirement of maintenance dialysis.  CKD requiring dialysis is associated with severe clinical outcomes and mortality in patients with COVID-19; however, the development of AKI is more strongly associated with severe clinical outcomes and mortality.
Convulsive Status Epilepticus in a Child With Controlled Epilepsy and Concurrent COVID-19 Infection: A Case Report and a Quick Review	Khair,  AM,  Husain, et al	Clinical Medicine Insights: Case Reports	Clinical data| Données cliniques	We report a child with convulsive status epilepticus and confirmed COVID-19 infection. Brief review of current available literature was discussed.
Host Specific SARS-CoV-2 Mutations: Insertion of the Phenylalanine in the NSP6 Linked to the United Kingdome and Premature Termination of the ORF-8 Associated with the European and the United States of America Derived Samples	Khalid,  Mohammad,  Al-ebini, et al	bioRxiv	Epidemiology| Épidémiologie Coronavirology| Coronavirologie	In the present study, we have analysed full-length SARS-CoV-2 genome sequences, derived from symptomatic/asymptomatic COVID-19 patients from all six continents to investigate the common mutations globally. Our results revealed that SARS-CoV-2 is mutating independently, we identified total 313 mutations and some (21 mutations) of them are prevailing over time irrespective of geographical location. Another important finding, we are reporting here is, the mutation rate of the virus varies in different geographical locations suggesting the virus is adapting different strategies in the infected populations, having different genetic backgrounds across the globe. We have identified 11085TTT insertion (insertion of the Phenylalanine in NSP6 at position 38) mutation, which is mainly linked to the UK derived SARS-CoV-2 samples, we have also discovered non-sense mutation in ORF-8 after 17 amino acid is linked to the European and the USA derived SARS-CoV-2 samples.
BMI as a Risk Factor for Clinical Outcomes in Patients Hospitalized with COVID-19 in New York	Kim,  TS,  Roslin, et al	Obesity	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study examined the association between BMI and clinical outcomes among patients with coronavirus disease 2019 (COVID‐19) infection by studying 10,861 patients in New York.  Patients who had overweight (odds ratio [OR] = 1.27 [95% CI: 1.11‐1.46]), obesity class I (OR = 1.48 [95% CI: 1.27‐1.72]), obesity class II (OR = 1.89 [95% CI: 1.56‐2.28]), and obesity class III (OR = 2.31 [95% CI: 1.88‐2.85]) had an increased risk of requiring  invasive mechanical ventilation (IMV). Underweight and obesity classes II and III were statistically associated with death (OR = 1.44 [95% CI: 1.08‐1.92]; OR = 1.25 [95% CI: 1.03‐1.52]; OR = 1.61 [95% CI: 1.30‐2.00], respectively).
Analysis of symptoms of covid-19 positive patients and potential effects on initial assessment	Korell,  F,  Giannitsis, et al	Open Access Emergency Medicine	Epidemiology| Épidémiologie Clinical data| Données cliniques	The goal of this study is the evaluation of different patient groups in Germany with a focus on symptoms and pre-existing illness at admission, as this is important for initial assessment and adequate emergency care. Dyspnea was more common in patients admitted to intermediate care/intensive care units (48 vs 13%, P< 0.001) and showed a significantly higher percentage in the deceased (91 vs 48%, P=0.004). The symptoms of all presenting patients were highly variable, and many manifestations commonly associated with COVID-19 like cough, fever, and sore throat were only detected in a subset of patients, 60%, 43%, and 33%, respectively.
ACE2 peptide fragment interacts with several sites on the SARS-CoV-2 spike protein S1	Kuznetsov,  Aleksei,  Arukuusk, et al	bioRxiv	Coronavirology| Coronavirologie	We explored the ACE2 binding site by loading it onto the biosensors and studied the influence of the peptide on the kinetics of the S1-ACE2 interaction. The on-rate and off-rate of S1-ACE2 complex formation were measured in the presence of various peptide concentrations using Bio-Layer Interferometry (BLI). The formation of the S1-ACE2 complex was inhibited when the S1 protein was preincubated with the peptide, however, no significant inhibitory effect was observed in the absence of preincubation. Dissociation kinetics revealed that the peptide remained bound to the S1-ACE2 complex and stabilized this complex. Computational mapping of the S1 protein surface for peptide binding revealed two additional sites, located at some distance from the receptor binding domain (RBD) of S1.
Secondary transmission of COVID-19 in preschool and school settings in northern Italy after their reopening in September 2020: a population-based study	Larosa,  E,  Djuric, et al	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin	Epidemiology| Épidémiologie Transmission	We report epidemiological investigations of transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 41 classes of 36 schools in Reggio Emilia province, northern Italy, from their reopening on 1 September to 15 October 2020. The overall secondary case attack rate was 3.2%, reaching 6.6% in middle and high schools. More timely isolation and testing of classmates could be effective in reducing virus transmission in this setting.
Determinants of Developing Symptomatic Disease in Ethiopian COVID-19 Patients: A Case-Control Study	Leulseged,  Tigist Workneh,  Alemahu, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim of this case-control study was to assess the determinants of having symptomatic disease among COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia. Developing a symptomatic COVID-19 disease was found to be determined by exposures of old age, male sex, and being diabetic.
The Impact of Age on Negative Emotional Reactions, Compliance With Health Guidelines, and Knowledge About the Virus During the COVID-19 Epidemic: A Longitudinal Study From Israel	Levkovich,  I	Journal of Primary Care and Community Health	Public Health response| Interventions de santé publique	In a longitudinal study we examined the impact of age on negative emotional reactions, compliance with health guidelines in Israel and knowledge about the virus during the COVID-19 epidemic. In the first phase (March 12-21) and second phase (April 23 to May 5), compliance with health guidelines was highest among participants over the age of 50. Knowledge was significantly higher in the second phase than in the first among participants over age 50 and those between the ages of 40 and 50. In the second phase, knowledge did not differ by age group. Negative emotional reactions were significantly higher in the first phase than in the second. Moreover, negative emotional reactions were higher among participants up to age 30 than among all other participants.
Potential COVID-19 Therapeutic Approach Analysis through AT2 Cell Targeted Treatment	Li,  J		Coronavirology| Coronavirologie	We research the most vulnerable cell type that susceptible for the COVID-19 infection can provide a faster and more precise method in fighting against the disease. Alveolar type 2 progenitor cells (AT2 cell), known as "stem-like" cells in the lung tissue helping decrease lung injury and control immune response in lung area, have long been regarded as critical cells for the development of adenocarcinoma.
Depression is associated with moderate-intensity physical activity among college students during the covid-19 pandemic: Differs by activity level, gender and gender role	Lin,  J,  Guo, et al	Psychology Research and Behavior Management	Mental Health | santé mentale	We aimed to examine the association between depressive symptoms and physical activity (PA) among college students with different gender and gender role (masculinity traits and femininity traits) during the COVID-19 pandemic through a cross-sectional study. A total of 34.72% participants had clinically relevant depression (16, CES-D scale). Total of 58.6% participants were classified as a “low” activity level for spending less time on PA. Depression significantly negatively correlated with MET-minutes/week in moderate-intensity PA but not vigorous and walking scores. Of note, the depression-PA association was only moderated by the “low” activity level group in terms of categorical scores across gender groups. Participants with higher masculinity traits were less likely to have depression among all participants.
Rapid expression of COVID-19 proteins by transient expression in tobacco	Lindsay,  PenelopeL,  Ackerman, et al	bioRxiv	Coronavirology| Coronavirologie	Here we report the production of two SARS-CoV-2 proteins using transient expression in tobacco. We compare different expression systems and codon optimized constructs, and show that high levels of expression can be obtained in just a few days, and that recombinant proteins can be purified using routine epitope tagging. Such approaches can help protein production for basic research as well as applied applications such as development of diagnostics and vaccine production.
Rapid detection of SARS-CoV-2-specific memory T-cell immunity in recovered COVID-19 cases	Lineburg,  KE,  Srihari, et al	Clinical and Translational Immunology	Clinical data| Données cliniques Immunology | Immunologie	Here, we have developed a rapid immune‐monitoring strategy to assess virus‐specific memory T‐cell responses in the peripheral blood of COVID‐19 convalescent individuals. T‐cell immunity characterised by the production of IFN‐γ and IL‐2 could be consistently detected in the whole blood of recovered participants. T cells predominantly recognised structural SARS‐CoV‐2 proteins. In vitro expansion demonstrated that while CD8+ T cells recognised nucleocapsid protein, spike protein and ORF3a, CD4+ T cells more broadly targeted multiple SARS‐CoV‐2 proteins.
Clinical Assessment of the Roche SARS-CoV-2 Rapid Antigen Test	Lippi,  Giuseppe,  Gianfilippi, et al	SSRN- Lancet prepublication	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The purpose of this study was the clinical assessment of the new Roche SARS-CoV-2 Rapid Antigen Test. The overall accuracy of Roche SARS-CoV-2 Rapid Antigen Test compared to molecular testing was 86.9%, with 72.5% sensitivity and 99.4% specificity. Progressive decline in performance was observed as cycle threshold (Ct) values of different SARS-CoV-2 gene targets increased. The sensitivity was found to range between 97-100% in clinical samples with Ct values <25, between 50-81% in those with Ct values between 25-<30, but low as 12-18% in samples with Ct values between 30-<37
Design of Specific Primer Set for Detection of B.1.1.7 SARS-CoV-2 Variant using Deep Learning	Lopez-Rincon,  Alejandro,  Perez-Romero, et al	bioRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Using a completely automated pipeline involving deep learning techniques, we designed a primer set which is specific to SARS-CoV-2 variant B.1.1.7 with >99% accuracy, starting from 8,923 sequences from GISAID. The resulting primer set is in the region of the synonymous mutation C16176T in the ORF1ab gene, using the canonical sequence of the variant B.1.1.7 as a reference. Further in-silico testing shows that the primer set's sequences do not appear in different viruses, using 20,571 virus samples from the National Center for Biotechnology Information (NCBI), nor in other coronaviruses, using 487 samples from National Genomics Data Center (NGDC).
Risk perception, knowledge, social distancing measures of covid-19 pandemic among south indian population	Mahajan,  SS,  Sukumaran, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	The objective of this study was to monitor variables that are critical for behavioral change in the South Indian population and the measures taken to avoid transmission of COVID-19 pandemic including risk perceptions, knowledge, and social distancing measures. This survey reveals that the community has acquired adequate knowledge regarding the pandemic and practiced safe social distancing measures in general. An interesting fact which emerged was the male gender tended to go out more, were more risk-taking though professing to be more apprehensive.
Effects of covid-19 outbreak and lockdown-a questionnaire based study	Mahalingam,  NV,  Preetha, et al	International Journal of Current Research and Review	Mental Health | santé mentale Public Health response| Interventions de santé publique	The aim of the current cross-sectional study is to assess the knowledge, attitude, the anxiety experienced among the general population of Chennai during the COVID-19 pandemic outbreak and lockdown. The survey has concluded that the COVID-19 pandemic outbreak and lockdown have led to fear of death among the general population, domestic abuse, unemployment, and financial crisis as a negative impact.
A survey on chennai population on awareness and practice on importance of oral hygiene in present covid-19 situation	Maheshwaran,  B,  Ramesh, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	The purpose of the study was to know about the awareness and practice of oral hygiene among the general population and maintenance of oral health among the adult population in the present COVID situation. A small population of Chennai of 174 was aware of oral hygiene, especially during the current COVID-19 situations.
Interstate disparities in the performances in combatting COVID-19 in India: efficiency estimates across states	Maity,  S,  Ghosh, et al	BMC Public Health	Epidemiology| Épidémiologie	The objective of this study was to investigate the comparative efficiency of Indian states to combat COVID-19 and to unfold the factors responsible for interstate disparities in the efficiency in combatting COVID-19. The empirical results demonstrated the existence of disparities across Indian states in the level of efficiency in combatting COVID-19. A non-trivial outcome of this study was that Tamil Nadu was the best performer and Manipur was the worst performer of the investigated states. Variables such as elderly people, sex ratio, literacy rate, population density, influenced the efficiency of states, and thus, affected the recovery rate.
Parents concern regarding dental treatment for children during covid-19-a survey	Meenapriya,  M,  Gurunathan, et al	International Journal of Current Research and Review	Healthcare Response | Réponse des soins de santé	The aim of this study is to assess the difficulties faced by the parent for dental treatment in their child during COVID-19. The difficulties faced by the parents in the treatment of their child during COVID-19 were most commonly associated with the transportation problem. Most of the parents preferred home remedies due to the fear of the pandemic situation. The prevalence of dental emergencies among children is comparatively lesser. Awareness about the essential and non-essential dental treatment prevails.
A study on the impact of pandemic covid-19 on global economy-a questionnaire based study	Monesh Babu,  JD,  Preetha, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	This study assessed peoples awareness of the economic effects of the COVID-19 pandemic. The study was conducted with a study population of 136 subjects. It was evident that most of the respondents (93.33%) were aware of the impact of pandemic COVID-19 on the global economy. Men (52%) are more concerned about the impact of COVID on the economy than women (42%). However, the difference is more distinct with regard to corporate jobs where men are twice as concerned as women.
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species	Moustaqil,  M,  Ollivier, et al	Emerg Microbes Infect	Coronavirology| Coronavirologie	The genome of SARS-CoV-2 encodes two viral proteases (NSP3/ papain-like protease and NSP5/ 3C-like protease) that are responsible for cleaving viral polyproteins during replication. Here, we discovered new functions of the NSP3 and NSP5 proteases of SARS-CoV-2, demonstrating that they could directly cleave proteins involved in the host innate immune response.
Awareness among college students on the changes in hematological parameters due to covid-19	Muralidharan,  VA,  Gayatri Devi, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	The main aim of the survey in this study is to create awareness among college students on the various changes in hematological parameters during COVID-19. A questionnaire was prepared and administered to a hundred participants through Google forms an online platform. These study participants included college students of Saveetha dental college. The overall result was positive as most of the study population were aware of the change in the hematological parameters due to COVID-19.
Single center experience on screening oncology patients for covid-19 before anti-cancer treatment	Namal,  E,  Dinc, et al	UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi	Epidemiology| Épidémiologie Clinical data| Données cliniques	We’ve tested oncology patients, that receive anti-cancer therapy, for COVID-19. We aimed to determine the rate of asymptomatic carriers, and analyze the clinical and radiological findings of infected patients. PCR test was positive in 28 of 312 patients that we tested, and the positivity rate was 8.9%. Three patients (10.7%) had symptoms, 25 patients (89.3%) had no symptoms.
Losartan promotes cell survival following SARS-CoV-2 infection in vitro</em&gt	Nejat,  Reza,  Sadr, et al	bioRxiv	Therapeutics| Thérapeutique	This study addressed the hypothesis that angiotensin II type I receptor blocker, Losartan, may restrict pathogenesis caused by SARS-CoV-2 by decreasing viral-induced cytopathological changes by blocking angiotensin II type 1 receptor (AT1R), thus reducing the affinity of the virus for ACE2, and inhibiting papain-like protease of the virus. Losartan treatment of Vero E6 cells prior to and after SARS-CoV-2 infection reduced SARS-CoV-2 replication by 80% and 70% respectively.
Structural dynamics of the SARS-CoV-2 frameshift-stimulatory pseudoknot reveal topologically distinct conformers	Neupane,  Krishna,  Zhao, et al	bioRxiv	Coronavirology| Coronavirologie	The RNA pseudoknot that stimulates −1 programmed ribosomal frameshifting in SARS-CoV-2 is a possible drug target. To understand how this 3-stemmed pseudoknot responds to the mechanical tension applied by ribosomes during translation, which is thought to play a key role during frameshifting, we probed its structural dynamics under tension using optical tweezers. Results resolve the folding mechanism of the frameshift signal in SARS-CoV-2 and highlight the dynamic conformational heterogeneity of this RNA, with important implications for structure-based drug-discovery efforts.
PMC7764473; Spike glycoproteins: Their significance for corona viruses and receptor binding activities for pathogenesis and viral survival	Noman,  A,  Aqeel, et al	Microb Pathog	Coronavirology| Coronavirologie	We present the characteristic features of Coronaviruses (CoVs) spike (S)-Proteins, their significance for CoVs and related receptor binding activities for pathogenesis and viral survival. We are analyzing the novel role of S-protein of CoVs along with their interactive receptors for improving host immunity and decreasing infection spread.
SARS-CoV-2 spike glycoprotein S1 induces neuroinflammation in BV-2 microglia	Olajide,  OlumayokunA,  Iwuanyanwu, et al	bioRxiv	Coronavirology| Coronavirologie Immunology | Immunologie	In this study, we investigated the effects of the SARS‐CoV‐2 spike glycoprotein S1 stimulation on neuroinflammation in BV-2 microglia. Results have provided the first evidence demonstrating SARS-CoV-2 spike S1 glycoprotein-induced neuroinflammation in BV-2 microglia. We propose that promotion of neuroinflammation by this glycoprotein is mediated through activation of NF-κB, NLRP3 inflammasome and p38 MAPK.
Knowledge and Level of Adherence to COVID-19 Preventive Measures: A Bi-national Web-based Survey in Africa	Omotoso,  OlabodeE,  Awoyemi, et al	Research Square prepub	Public Health response| Interventions de santé publique	We assessed the knowledge and level of adherence of Nigerians and Egyptians to the COVID-19 precautionary measures. Most Egyptians (87%) had satisfactory COVID-19 knowledge compared to Nigerians (40%). Age (18 – 30 years), tertiary education and educational background (medical or scientific) were major factors that influenced respondents’ COVID-19 knowledge levels. The level of adherence of most respondents (59.1%) to COVID-19 precautionary measures was unsatisfactory. The coronavirus pandemic and the instituted regulatory policies had a negative effect on respondents’ education, school or job (90.3%), finance (87.9%) and social interaction (87.5%).
Study of Outcomes and Characteristics of COVID-19 Positive Geriatric Patients in a Scottish Rehabilitation Community Hospital	Ong,  Ying Ern Elena,  Khor, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques	As the profound chronic health effects of COVID-19 on our ageing populations are still poorly understood, our study aims to investigate patient characteristics and outcomes in this cohort of patients stepped-down to the community geriatric hospital COVID-19 ward. 33 COVID-19 positive patients were included in this study. 36% of patients lost their independent function status and there was a 45% increase (15 patients) in care requirements, accompanied by a 41% decline mobility. Stroke as a co-morbidity was associated with increased mortality in this patient cohort. Obstructive lung disease is noted to be associated with an increased length of stay.
Analysis model of the most important factors in Covid-19 through data mining, descriptive statistics and random forest	Ortiz,  RIH,  Barrera, et al		Epidemiology| Épidémiologie	We propose using a classification-oriented machine learning method, we do a classic data science process so that we can perform noise cleaning and data processing to do descriptive statistical analysis in such a way that the most important variables or factors are identified through unsupervised learning. And with this it is appreciated that the most important variables for the risk of infection and mortality that Covid-19 disease can have are diseases that affect the immune system, such as diabetes, heart disease, hypertension and also kidney disease. Finally, this work opens the door to other investigations with the aim of conducting centralized investigations on each variable related to Covid-19, in order to find relevant information that can promote an improvement in the current situation.
Awareness of infection control from ncovid-19 a survey among denture wearers	Padmaja,  S,  Maiti, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	This survey is conducted to know the awareness level among older people regarding COVID-19. This tests their knowledge of infection control of COVID-19 and the hygiene measures they follow to disinfect the dentures. Nearly half of our population was aware of the infection control methods. But still, some of them have to be made aware of the infection control.
Lentiviral vector-based SARS-CoV-2 pseudovirus enables analysis of neutralizing activity in COVID-19 convalescent plasma	Pamukcu,  Cevriye,  Celik, et al	bioRxiv	Coronavirology| Coronavirologie Therapeutics| Thérapeutique Immunology | Immunologie	We present our approach to optimize GFP-encoding lentiviral particles pseudotyped with the SARS-CoV-2 Spike and Membrane proteins for use in neutralization assays. Our results show the feasibility of pseudovirus production using a C-terminal truncated Spike protein which is greatly enhanced by the incorporation of the D614G mutation. Analysis of convalescent plasma (CP) neutralizing activity against particles pseudotyped with wildtype or D614G mutant Spike protein in the presence or absence the M protein revealed differential activity in CP samples that did not necessarily correlate with the amount of anti-SARS-CoV-2 antibodies. Our results indicate that the extent of neutralizing activity in CP samples depends on the quality rather than the quantity of the humoral immune responses and varies greatly between donors. Functional screening of neutralizing activity using pseudovirus-based neutralization assays must be accepted as a critical tool for choosing CP donors if clinical efficacy is to be maximized.
Using in silico viral kinetic models to guide therapeutic strategies during a pandemic: An example in SARS-CoV-2	Patel,  K,  Dodds, et al	Br J Clin Pharmacol	Therapeutics| Thérapeutique	A target cell-limited model was used to quantify the viral infection dynamics of SARS-CoV-2 in a pooled population of 105 infected patients. Parameter estimates from the resulting model were used to simulate and compare the impact of various interventions against meaningful viral load endpoints. We show that early intervention is crucial to achieving therapeutic benefit when monotherapy is administered. In contrast, combination regimens of two or three drugs may provide improved outcomes if treatment is initiated late. The latter is relevant to SARS-CoV-2, where the period between infection and symptom onset is relatively long. The use of in silico models can provide viral load predictions that can rationalize therapeutic strategies against an emerging viral pathogen.
Uncovering Flexible Active Site Conformations of SARS-CoV-2 3CL Proteases through Protease Pharmacophore Clusters and COVID-19 Drug Repurposing	Pathak,  N,  Chen, et al	ACS Nano	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Aiming for effective treatments against COVID-19, we focused on the key drug target, the viral 3C-like (3CL) protease. We modeled a big dataset with 42 SARS-CoV-2 3CL protease-ligand complex structures from ∼98.7% similar SARS-CoV 3CL protease with abundant complex structures. Experimental testing by SARS-CoV-2 3CL protease inhibition assay and antiviral cytopathic effect assays discovered active hits, Boceprevir and Telaprevir (HCV drugs) and Nelfinavir (HIV drug). Specifically, Boceprevir showed strong protease inhibition with micromolar IC(50) of 1.42 μM and an antiviral activity with EC(50) of 49.89 μM, whereas Telaprevir showed moderate protease inhibition only with an IC(50) of 11.47 μM. Nelfinavir solely showed antiviral activity with a micromolar EC(50) value of 3.28 μM. Analysis of binding mechanisms of protease inhibitors revealed the role of pharmacophore clusters (PPC) core anchors. Our PPCs revealed the flexible protease active site conformations, which successfully enabled drug repurposing.
Assessing the Effectiveness of the Italian Risk-Zones Policy During the Second Wave of Covid-19	Pelagatti,  MatteoM	SSRN- Lancet prepublication	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	In this work, we extract the daily growth rate of new cases, hospitalizations, and patients in ICU in 21 regions of Italy, from official data using an unobserved components model and assess if the different restrictions had different effects in reducing the speed of spread of the virus.
Subgroup classification model identifying the most influential factors in the mortality of patients with COVID-19 using data analysis	Pena,  C,  Peralta, et al		Epidemiology| Épidémiologie	This research assesses the health conditions of the people in the study and determines the reason why a person dies after being infected with COVID-19. In this study, 538 sample groups that provided medical data from people in different locations were analyzed. After completing the data analysis, it is determined that the factors that aggravate the condition of a patient with COVID-19 are: hypertension, advanced age and any other disease.
Clinical and epidemiological profile of patients infected by COVID-19 at a tertiary care centre in North India	Prakash,  S,  Agrawal, et al	Monaldi Archives for Chest Disease	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim of this work is to describe the experience with clinical and epidemiologic features, as well as with the management of COVID-19 patients in north India. This is a descriptive study of the 17 COVID-19 patients confirmed with PCR and admitted to a tertiary care centre in India from March 11th 2020 to April 16th 2020. The present work also provides insight in to treatment provided and final outcome of the patients with COVID-19. Laboratory investigations in COVID-19 patients in the Indian subcontinent reveal lymphopenia as predominant finding in hemogram. Patients with older age and associated comorbidities (COPD, hypertension and diabetes) seem to have greater risk for lung injury.
Is the implication of covid-19 lockdown leading to stress and anxiety?-a questionnaire based study	Preethi,  G,  Preetha, et al	International Journal of Current Research and Review	Mental Health | santé mentale	The principal aim of this study is to know if the COVID-19 lockdown is having a stress impact on the mental health of the general population. From the present study, it is inferred that 85% of the study participants are undergoing mental and emotional stress. It is evident that the COVID-19 lockdown is bringing a great impact on people both mentally and physically.
Disturbances of the hemostasis system and expression of inflammatory reaction in patients with new coronaviral pneumonia	Presnyakova,  MV,  Galova, et al	Klin Lab Diagn	Epidemiology| Épidémiologie Clinical data| Données cliniques	To study the dynamics of the state of the hemostasis system and the severity of the acute phase response in patients with new coronavirus pneumonia (NCP). In 49 patients, the viscoelastic properties of a blood clot were studied by thromboelastography (TEG) with koalin. According to CT, the severity of 100% cases corresponded to CT2-CT3. Acute respiratory failure (ARF) was diagnosed in 16 patients. During hospitalization, patients with NCP were characterized by: an increase in the concentration of D-d, CRP, Fg, lengthening of APTT and PT, ATIII activity and platelet count not differing from the normal range. 10 days after hospitalization and against the background of ongoing therapy, patients with NCP showed positive dynamics in the hemostasiological profile and the severity of the inflammatory response. Thromboelastography indices in patients with LCP did not differ from control values both at hospitalization and on day 10. In patients with NCP, an increased prothrombotic activity and a pronounced inflammatory response are recorded. Against the background of treatment, there is a positive dynamics in both the coagulation status and the inflammatory response.
Sociodemographic Characteristics and Transmission Risk Factors In Patients Hospitalized for COVID-19 Before And During The Lockdown In France	Rahi,  Mayda,  Le Pluart, et al	Research Square prepub	Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions de sant&amp;eacute; publique	The aim of this study was to describe the changes in sociodemographic characteristics of patients hospitalized for COVID-19 and to compare the transmission risk factors of COVID-19 before and during lockdown in France. The study population was divided into 2 groups: group A of patients infected before lockdown, and group B of patients infected during lockdown, considering a maximum incubation period of 14 days. Three hundred eighty-three patients were included in the study, 305 (79.6%) in group A and 78 (20.4%) in group B. Patients in group A were significantly younger (60.0 versus (vs) 66.5 years (p=0.03)). The professionally active population was larger in group A (44.3% vs 24.4%). There were significantly more non-French-speaking people in group B (16.7% vs 6.6%, p<0.01). Most patients from group A had individual accommodation (92.8% vs 74.4%, p<0.01). Contact with a relative was the main transmission risk factor in both groups (24.6% vs 33.3%, p=0.16). Recent travel and large gathering were found only in group A. The proportion of people living in disadvantaged conditions, such as homeless people or people living in social housing, was significantly higher in group B (11.5% vs 4.3%, p=0.03) as was the proportion of institutionalized individuals (14.1% vs 3.0%, p<0.01).
Awareness on spread of misinformation and its effect on public with regard to covid-19	Ramasubramanian,  S,  Preetha, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	The aim is to analyze the effect of social media on the public with regard to COVID-19.  On analyzing the data majority of the participants used WhatsApp and Facebook for news updates regarding COVID-19, 46% were aware of authentic websites to cross-check the news and 77% of the participants agreed that they get disturbed with a lot of information related to COVID-19.
Paired SARS CoV-2 Spike Protein Mutations Observed During Ongoing SARS-CoV-2 Viral Transfer from Humans to Minks and Back to Humans	Rubsamen,  Reid,  Burkholz, et al	bioRxiv	Coronavirology| Coronavirologie zoonoses	Study SARs-CoV-2 mutations in infected mink populations. The viral genomic mutations in minks observed in the Netherlands and Denmark show the potential for new mutations on the SARS-CoV-2 spike protein RBD to be introduced into humans by zoonotic transfer. Our data suggests that close attention to viral transfer from humans to farm animals and pets will be required to prevent build-up of a viral reservoir for future zoonotic transfer.
Awareness about covid-19 precautions and case management among paramedics-a questionnaire based survey	Ruskin,  P,  Abilasha, et al	International Journal of Current Research and Review	Healthcare Response | Réponse des soins de santé	The aim of this investigation is to assess the awareness of COVID-19 disease control among paramedics as they are the frontline caregivers especially in emergency situations. The population showed positive results with good awareness on COVID 19 and case management. More than 90% of responders are aware of their need to follow safety measures implemented by the government.
A reflection on explanatory factors for COVID-19: A comparative study between countries	Santos,  E,  Oliveira, et al	Thunderbird International Business Review	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	This article aims to perform a comparative study between countries with a population similar to the Portuguese in number of inhabitants and to find out which factors may explain the numbers registered with the COVID-19 pandemic. The results show that the countries that carried out more population tests have higher values in tourism, security, innovation, competitiveness, and GDP per capita indicators. There is a significant and positive relationship between temperature and the daily cases of COVID-19 infections. The results found contribute to a greater knowledge of the behavior of this disease according to the characteristics of each country, making it useful for international business managers to compare and contrast different country environmental conditions in order to define alternative strategies to overcome this great period of disturbance more quickly.
Extracorporeal Membrane Oxygenation for COVID-19-Associated Multisystem Inflammatory Syndrome in a 5-year-old	Schwartz,  SP,  Walker, et al	Am Surg	Clinical data| Données cliniques	This is a case study report of a 5-year-old girl diagnosed with SARS-CoV-2 associated with multi-system inflammatory syndrome in children (MIS-C).  She presented with shock and a rapid decline in left ventricular function requiring intubation and received remdesivir and COVID-19 convalescent plasma as treatment. Due to her severe cardiogenic shock, she was cannulated for venoarterial extracorporeal support (ECMO). The case study authors reported that the use of ECMO for cardiopulmonary support for pediatric patients with MIS-C is feasible and should be considered early as part of the treatment algorithm for patients with severe cardiopulmonary dysfunction.
Documented Reasons of Cancellation and Rescheduling of Telehealth Appointments During the Pandemic	Sezgin,  E,  Huang, et al	Telemed J E Health	Healthcare Response | Réponse des soins de santé	The COVID-19 pandemic increased the use of telehealth around the world with the aim of minimizing health care service disruption and reducing COVID-19 exposure. However, one of the major operational concerns is cancellations and rescheduling (C/Rs) of telehealth appointments which could create additional burden and cost to the patient, provider, and the health system.  The aim of this study is to understand the reasons for C/Rs of the telehealth session after the scheduled start time. The study shows that engagement is one of the new challenges to the pediatric telehealth visits indicating that future studies of new engagement models are needed for the success of telehealth.
Risk perception regarding the COVID-19 outbreak among the general population: a comparative Middle East survey	Shahin,  MAH,  Hussien, et al	Middle East Current Psychiatry	Public Health response| Interventions de santé publique	The aim of this descriptive, cross-sectional study of 723 convenience sample participants, recruited from Saudi Arabia, Egypt, and Jordan is to investigate risk perceptions regarding the coronavirus disease 2019 (COVID-19) outbreak, among the general population. The study concluded that during the COVID-19 pandemic, communications designed to promote the adoption of preventive behaviors should focus on increasing the perception of seriousness, the risk perception, self-efficacy to cope with the COVID-19 pandemic, and the effectiveness of the adopted behavioral measures for reducing risk.
Deep learning time series to forecast COVID-19 active cases in INDIA: A comparative study	Shaik,  MA,  Verma, et al		Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	This paper investigates the precision of various "Time series"modeling techniques for detecting "corona virus outbreak"in topmost ten different states with the maximum number of "confirmed cases"as on 31 August 2020 in India.  Six different deep learning approaches of time series were implemented to compare the values associated in datasets that relates to the progression of the virus in each state based on the population. The attained results showed that the scaling of time series methods can accurately predict various affected aspects of the virus in near future.
Knowledge and awareness on role of social media in managing covid-19 among general population-a questionnaire study	Shankari,  SB,  Rani, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	Aim of the study is to analyze the role of social media in COVID-19.  Following  a cross-sectional survey in Coimbatore and Chennai districts of Tamil Nadu about knowledge, awareness, and perception in the role of social media it was revealed that people were somehow aware of the current status of COVID-19 and they have gained knowledge of the control and prevention of COVID-19 through social media..
Higher SARS-CoV-2 Seroprevalence in Workers with Lower Socioeconomic Status in Cape Town, South Africa	Shaw,  Jane Alexandra,  Meiring, et al	Research Square prepub	Epidemiology| Épidémiologie Immunology | Immunologie	This study was undertaken to assess the SARS-CoV-2 seroprevalence and the specificity of anti-SARS-CoV-2 antibody tests in South Africa. As such, 405 volunteers representing all socioeconomic strata from the workforce of a popular shopping and tourist complex in central Cape Town were assessed to determine the association between antibody positivity and COVID-19 symptom status.  The study concluded that there was a high background seroprevalence in Cape Town, particularly in people of lower socioeconomic status with half of cases being asymptomatic, and therefore undiagnosed by local testing strategies. These results cannot be explained by low assay specificity., medical history, and sociodemographic variables.
Knowledge and awareness on the role of hand sanitizer in prevention of covid 19-a questionnaire survey	Shree,  MK,  Leslie Rani, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	This cross-sectional Questionnaire survey aims to assess the knowledge of the general population on hand sanitization and also to evaluate the importance given for hand hygiene in controlling the spread of disease in the Dindigul district, Tamil Nadu. The conclusion of this article is that nearly 80% of people are aware of the importance of hand sanitizer in pandemic conditions is COVID-19, p-value = 0.773 which is statistically significant. As well, the survey reported that people agreed that the usage of hand sanitizer prevents diseases and helps good hygiene.
Previous dengue infection and mortality in COVID-19	Silvestre,  OM,  Costa, et al	Clin Infect Dis	Clinical data| Données cliniques	We studied 2351 COVID-19 participants to determine whether previous dengue infection provides a protective effect against the virus. Fifty percent 1177 of the participants reported previous dengue infection while those without previous dengue had a higher risk of death (hazard ratio: 0.44; 95% CI: 0.22 to 0.89; p = 0.023) in 60-day follow-up time period. These findings raise the possibility that dengue might induce immunological protection against SARS COV-2.
Emerging challenges faced by dentists after covid-19 pandemic in India	Sogasu,  D,  Somasundaram, et al	International Journal of Current Research and Review	Healthcare Response | Réponse des soins de santé	The aim of this online survey is to understand and analyze the various emerging challenges that dentists will face in the future after COVID 19 pandemic in India. The results suggest that the primary challenges to be faced by the dentists will be dependent on their geographical location. The most important challenge anticipated by the majority of dentists is the increased use of PPE and aerosol production, in the same order.
Face Recognition and Temperature Data Acquisition for COVID-19 Patients in Honduras	Sorto,  A,  Marquez, et al		Healthcare Response | Réponse des soins de santé	The primary purpose of this project is the design and development of software that performs facial recognition and temperature registration for patients in Honduras.  Study results indicate that at a maximum distance of 1.4 meters from the camera, the system obtained 72% and 82% accuracy for each of the tests. Finally, the authors concluded that the system can be implemented in health areas such as laboratories, hospitals, and clinics so that contact between patients and doctors can be reduced.
COVID-19: Contextualizing Misinformation Flows in a US Latinx Border Community (Media and Communication During COVID-19)	Soto-Vásquez,  AD,  Gonzalez, et al	Howard Journal of Communications	Public Health response| Interventions de santé publique	This study shows how research on misinformation correction on social media must be contextualized by an understanding of race, class, and local culture. Using an inductive analysis of focus group data, we find that correction of misinformation about the COVID-19 pandemic on the US/Mexico border is multilayered between the family and community institutions. The study concludes that correction of misinformation does occur in the intimate networks of family and friends in online group chats, discussions around the television, and interpersonal communication.
Awareness of covid-19 among South Indian population	Surya,  C,  Rani, et al	International Journal of Current Research and Review	Public Health response| Interventions de santé publique	The aim of the study is to create an awareness level of COVID-19 among the South Indian population.  A 15 cross-sectional questionnaire was conducted among 100 south Indian populations during May 2020 to ascertain data. Results from the survey indicate that most of the south Indian population were aware of the causes, risk factors, mode of transmission, incubation period, home remedies, and treatment for coronavirus.
Post-exposure Prophylaxis Against SARS-CoV-2 in Close Contacts of Confirmed COVID-19 Cases (CORIPREV): Study Protocol for a Cluster-randomised Trial	Tan,  Darrell,  Chan, et al	Research Square prepub	RCT	The primary objective of the COVID-19 Ring-based Prevention Trial with lopinavir/ritonavir (CORIPREV-LR) is to evaluate the efficacy of a 14-day course of oral lopinavir/ritonavir as Post-exposure prophylaxis (PEP) against COVID-19 among individuals with a high-risk exposure to a confirmed case. This was an open-label, multi-center, 1:1 cluster-randomized trial of LPV/r versus no intervention.  This trial will harness safe, existing drugs such as LPV/r as PEP could provide an important tool for control of the COVID-19 pandemic. Novel aspects of trial  design include the ring-based prevention approach, and the incorporation of remote strategies for conducting study visits and biospecimen collection.
Detection of SARS-CoV-2 RNA in nasopharyngeal swabs from COVID-19 patients and asymptomatic cases of infection by real-time and digital PCR	Ternovoi,  VA,  Lutkovsky, et al	Klin Lab Diagn	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	We tested two reagent kits developed by us for detecting SARS-CoV-2 RNA using a fragment of the ORF1ab gene in digital PCR and real-time PCR formats using data obtained from the detection of SARS-CoV-2 virus RNA in nasopharyngeal swabs of patients with COVID-19 and asymptomatic carriers. Testing was based on a panel of 1,328 samples collected from patients with suspected COVID-19 at the beginning of 2020 in the Russian Federation. Study results showed that using the digital PCR method for detecting SARS-CoV-2 RNA is especially suitable for detecting RNA in case of its low concentration in contacts, as well as for monitoring changes in viral load in convalescent patients.
Patterns of seroconversion for SARS-CoV2-IgG in patients with malignant disease and association with anti-cancer therapy	Thakkar,  Astha,  Pradhan, et al	Research Square prepub	Clinical data| Données cliniques Immunology | Immunologie	We conducted a retrospective cohort study of 261 cancer patients who underwent SARS-CoV-2 IgG testing with high rates of seroconversion (92%) to determine  the association between rates of SARS-CoV-2 IgG seroconversion and various cancer types and anti-cancer therapies. The study data show differential rates of seroconversion in specific patient groups and bear importance for clinical monitoring and vaccination strategies that are being developed to mitigate the COVID-19 pandemic.
In silico analysis of phytochemicals as potential inhibitors of proteases involved in SARS-CoV-2 infection	Umadevi,  P,  Manivannan, et al	J Biomol Struct Dyn	Therapeutics| Thérapeutique	In silico analysis of six phytochemicals, flabelliferin, marmelosin, piperine, ocimin, curcumin and leucoanthocyanin, along with three drug compounds, nelfinavir, remdesivir and hydroxychloroquine, as positive control against drug targets of one SARS-CoV-2 viral protease, COVID-19 main protease (SARS CoV-2 3CL(pro)/M(pro)), two coronavirus proteases, SARS-CoV main peptidase (SARS CoV M(pro)), SARS-CoV main proteinase (SARS CoV 3CL(pro)), and one human cellular transmembrane serine proteinase (TMPRSS2), was carried out. The phytochemicals tested in the study show that they are potential inhibitors of the all the four drug targets and can form a part of therapeutics against COVID-19 with further clinical studies.
Identification of similar epitopes between severe acute respiratory syndrome coronavirus-2 and Bacillus Calmette–Guérin: potential for cross-reactive adaptive immunity	Urbán,  S,  Paragi, et al	Clinical and Translational Immunology	Vaccine Research| Recherche sur les vaccins	Bacillus Calmette–Guérin (BCG) vaccination has been implicated in protection against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and as a non-specific immunisation method against the virus.  As such,  this study was undertaken to investigate T-cell and B-cell epitopes within the BCG-Pasteur strain proteome for similarity to immunogenic peptides of SARS-CoV-2. The results provide a mechanistic basis for the potential cross-reactive adaptive immunity that may exist between the two microorganisms.
The Pathogenicity of COVID-19 Is Independent of Increasing Altitude: The Case of Colombia	Valverde-Bruffau,  V,  Cárdenas, et al	Am J Trop Med Hyg	Epidemiology| Épidémiologie	This letter expands on the analysis recently done by Cano-Perez et al that concluded that increasing altitude was associated with fewer SARS-2 infections, lower COVID19 mortality, and lower case fatality rate (CFR) by expanding the dataset from 70 municipalities to all 1,122 municipalities in Colombia, ranging in altitude from 2 to 3,259 m above sea level. In conclusion, data from Colombia show that there is no altitude gradient that is protective against SARS-CoV-2 infection or COVID-19 mortality.
Younger people are more vulnerable to stress, anxiety and depression during COVID-19 pandemic: A global cross-sectional survey	Varma,  P,  Junge, et al	Prog Neuropsychopharmacol Biol Psychiatry	Mental Health | santé mentale	This study examined the impact of the COVID-19 pandemic on psychological distress globally, and identified factors that may exacerbate decline in mental health. N = 1653 participants (mean age 42.90 ± 13.63 years; 30.3% males) from 63 countries responded to the survey.  Poor sleep, lower levels of resilience, younger age and loneliness significantly mediated the links between stress and depression, and stress and anxiety. Age-based differences revealed that younger age-groups were more vulnerable to stress, depression and anxiety symptoms.
Structural basis for broad coronavirus neutralization	Veesler,  David	bioRxiv	Immunology | Immunologie	(Preprint) We isolated a monoclonal antibody, termed B6, cross-reacting with eight β-coronavirus spike glycoproteins, including all five human-infecting β-coronaviruses, and broadly inhibiting entry of pseudotyped viruses from two coronavirus lineages. Our data provide a structural framework explaining B6 cross-reactivity with β-coronaviruses from three lineages along with proof-of-concept for antibody-mediated broad coronavirus neutralization elicited through vaccination.
Technical and clinical outcomes of endoscopic retrograde cholangiopancreatography (ERCP) procedures performed in patients with COVID-19	Voiosu,  T,  Voiosu, et al	Therapeutic Advances in Gastroenterology	Healthcare Response | Réponse des soins de santé	We aimed to assess the potential changes in the technical outcomes of endoscopic retrograde cholangiopancreatography (ERCP) procedures carried out in patients with confirmed SARS-CoV-2 infection. The COVID-19 pandemic has affected the volume and practice of ERCP, resulting in lower technical success rates without significantly impacting patient safety.
Views on the need to implement restriction policies to be able to address COVID-19 in the United States	Wang,  VH,  Pagán, et al	Prev Med	Public Health response| Interventions de santé publique	This study aimed to understand which different population groups of adults in the United States consider several key restriction policies as necessary to combat COVID-19. Views on each restriction policy varied substantially across some population segments such as age, race, and ethnicity. Regardless of population segments, those who followed news closely or considered themselves Democrat/lean Democrat were more likely to consider all the policies as necessary than those not following the news closely or those who considered themselves Republican/lean Republican.
Mental health problems in chinese healthcare workers exposed to workplace violence during the covid-19 outbreak: A cross-sectional study using propensity score matching analysis	Wang,  W,  Lu, et al	Risk Management and Healthcare Policy	Mental Health | santé mentale Healthcare Response | Réponse des soins de santé	This study aimed at examining the effect of medical workplace violence (MWV) on the mental health of Chinese healthcare workers during the outbreak of coronavirus disease 2019 (COVID-19). Chinese healthcare workers who experienced MWV were more likely to suffer from mental health problems than those who did not.
Installation of pedal-operated alcohol gel dispensers with behavioral nudges and changes in hand hygiene behaviors during the covid-19 pandemic: A hospital-based quasi-experimental study	Wichaidit,  W,  Naknual, et al	Journal of Public Health Research	Public Health response| Interventions de santé publique Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé	We conducted a quasi-experimental study and compared hand hygiene behaviors at potential pathogen transmission events among outpatient visitors (according to structured observations a trained enumerator) before and after installation of 12 pedal-operated alcohol gel dispensers with behavioral nudges (signs attached to the dispensers) at a tertiary hospital in southern Thailand during the COVID-19 pandemic. Prevalence of hand hygiene was significantly different between the pre-intervention and post-intervention periods (0 vs 24 events, or 0% vs 11%, respectively; p-value <0.001).
Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients	Xiang,  Haitao,  Zhao, et al	bioRxiv	Immunology | Immunologie	(Preprint) Here, we report a comprehensive characterization of the dynamics of immunoglobin heavy chain (IGH) repertoire in COVID-19 patients. by using next-generation sequencing technology. By employing clonotype overlap, lineage expansion and clonotype network analyses, we observed a higher clonotype overlap and substantial lineage expansion of B cell clones during 2-3 weeks of illness. For preferences of V gene usage during SARS-CoV-2 infection, IGHV3-74 and IGHV4-34 and IGHV4-39 in COVID-19 patients were more abundant than that of healthy controls.
Modeling and analysis of COVID-19 based on a time delay dynamic model	Yang,  C,  Yang, et al	Mathematical Biosciences and Engineering	Modelling/ prediction| Modélisation/prédiction	Based on the traditional infectious disease model, an infectious disease model with a time delay is proposed. This article has simulated COVID-19 and analyzed the development of the epidemic in Beijing and Wuhan. By comparing the severity of the epidemic in the two regions, early detection and isolation are still the top priority of epidemic prevention and control.
An Ultrasensitive Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and in vitro	Yang,  Xiaolong,  Liu, et al	bioRxiv	Coronavirology| Coronavirologie	(Preprint) Here we have developed an ultrasensitive bioluminescent biosensor to evaluate virus-cell interaction by quantifying the interaction between SARS-CoV-2 receptor binding domain (RBD) and its cellular receptor angiotensin-converting enzyme 2 (ACE2) both in living cells and in vitro. We have successfully used this novel biosensor to analyze SARS-CoV-2 RBD mutants, and evaluated candidate small molecules (SMs), antibodies, and peptides that may block RBD:ACE2 interaction.
Willingness to Receive Future Covid-19 Vaccines Following the Covid-19 Epidemic In Shanghai, China	Zhou,  Yehong,  Zhang, et al	Research Square prepub	Public Health response| Interventions de santé publique	We conducted a cross-sectional survey of Shanghai residents to understand residents' willingness to be vaccinated with any future COVID-19 vaccines and take measures to further improve vaccination coverage. Participants were more reluctant to accept COVID-19 vaccines for older individuals living with them. The presence of older individuals in the home also affected willingness of participants and their children to be vaccinated.
Features of α-HBDH in COVID-19 patients: A cohort study	Zhu,  H,  Qu, et al	J Clin Lab Anal	Clinical data| Données cliniques	Electronic medical records including demographics, clinical manifestation, α‐HBDH results and outcomes of all included patients were extracted to analyze the features of hydroxybutyrate dehydrogenase (α‐HBDH) in COVID‐19 patients. α‐HBDH was increased in COVID‐19 patients, obviously in ≥61 years old, death and critical group, indicating that patients in these three groups suffer from more serious heart and kidney and other tissues and organs damage, higher α‐HBDH value, and risk of death. The difference between death and survival group in early stage might provide a approach to judge the prognosis. The accuracy of the model to distinguish severe/critical type and other types was 85.84%, suggesting that α‐HBDH could judge the clinical type accurately.
Covid-19 in ethiopia: Assessment of how the ethiopian government has executed administrative actions and managed risk communications and community engagement	Zikargae,  MH	Risk Management and Healthcare Policy	Public health interventions*| Interventions de sant&amp;eacute; publique	This empirical study investigates all government and stakeholders’ effects in line with identifying the current status found in Ethiopia. KAP’s practices are inadequate to fight and minimize the impacts of the pandemic. The government is using several strategies and need to strengthen those efforts to mobilize and upbeat the KAP’s of the public through different communication forms to reinforce the existing efforts and alleviate socio-cultural, political, economic factors to drive out COVID-19 among the people. The efforts are building and strengthening up to the standard level of KAP’s while enhancing and promoting existing strategies and the drawing of new documents by focusing on high-risk parts of the population.
Time to Enhance Immunity via Functional Foods and Supplements: Hope for SARS-CoV-2 Outbreak	Ali,  Z,  Jatoi, et al	Altern Ther Health Med	Review Literature| Revue de littérature
Gender differences in treatment of Coronavirus Disease-2019	Ambrosino,  I,  Barbagelata, et al	Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace	Review Literature| Revue de littérature
COVID-19 diagnostic laboratory strategies: modern technologies and development trends (review of literature)	Andryukov,  BG,  Lyapun, et al	Klin Lab Diagn	Review Literature| Revue de littérature
Mucin signature as a potential tool to predict susceptibility to COVID-19	Bose,  M,  Mitra, et al	Physiol Rep	Review Literature| Revue de littérature
Community use of face masks and similar barriers to prevent respiratory illness such as COVID-19: a rapid scoping review	Brainard,  J,  Jones, et al	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin	Review Literature| Revue de littérature	ScR: systematically searched Scopus, Embase and MEDLINE. Wearing face masks may reduce primary respiratory infection risk, probably by 6-15%.
Characterising and managing paediatric SARSCoV-2 infection: Learning about the virus in a global classroom	Cardenas,  MC,  Bustos, et al	Acta Paediatrica, International Journal of Paediatrics	Review Literature| Revue de littérature
PMC7764469; Sofosbuvir/daclatasvir in the treatment of COVID-19 infection: a meta-analysis	Chan,  HT,  Chao, et al	J Infect	Review Literature| Revue de littérature	MA: sofosbuvir/daclatasvir-based treatment can be associated with a better clinical outcome than standard care or other comparators for COVID-19 infection.
Invisible Agents of COVID-19 Transmission? Common Sources, Characteristics, and Implications of Indoor Aerosols	Chen,  Bo,  Jia, et al	SSRN- Lancet prepublication	Review Literature| Revue de littérature
The potential role of dyslipidemia in covid-19 severity: An umbrella review of systematic reviews	Choi,  GJ,  Kim, et al	Journal of Lipid and Atherosclerosis	Review Literature| Revue de littérature
Background to new treatments for COVID-19, including its chronicity, through altering elements of the cytokine storm	Clark,  IA	Reviews in medical virology	Review Literature| Revue de littérature
Effects of sars-cov-2 on human reproduction	Dolgushin,  GO,  Romanov, et al	Akusherstvo i Ginekologiya (Russian Federation)	Review Literature| Revue de littérature
Diabetic Ketoacidosis on Hospitalization with COVID-19 in a Previously Nondiabetic Patient: A Review of Pathophysiology	Eskandarani,  RM,  Sawan, et al	Clinical Medicine Insights: Endocrinology and Diabetes	Review Literature| Revue de littérature
Palliative Care as Essential to a Hospital System's Pandemic Preparedness Planning: How to Get Ready for the Next Wave	Gelfman,  LP,  Morrison, et al	J Palliat Med	Review Literature| Revue de littérature
Pathophysiology and pharmacological management of pulmonary and cardiovascular features of COVID-19	Hamouche,  W,  Bisserier, et al	J Mol Cell Cardiol	Review Literature| Revue de littérature
A review on favipiravir: the properties, function, and usefulness to treat COVID-19	Hashemian,  SM,  Farhadi, et al	Expert Rev Anti Infect Ther	Review Literature| Revue de littérature
Curcumin a better medicine to treat coronavirus-a review	Imtiaz,  T,  Premavathy, et al	Indian Journal of Forensic Medicine and Toxicology	Review Literature| Revue de littérature
Health monitoring of people during lockdown due to corona virus (Covid-19)	Kumar,  V,  Gupta, et al	International Journal of Current Research and Review	Review Literature| Revue de littérature
Risk Mitigation Measures for Coronavirus Disease 2019	Lu,  Y,  Zhou, et al		Review Literature| Revue de littérature
Promotion of Physical Activity in Older People Using mHealth and eHealth Technologies: Rapid Review of Reviews	McGarrigle,  L,  Todd, et al	J Med Internet Res	Review Literature| Revue de littérature	Rapid Review: 3 electronic databases: MEDLINE, CINAHL Plus, and Scopus.  There is low to moderate evidence that interventions delivered via mHealth or eHealth approaches may be effective in increasing physical activity in older adults in the short term. Components of successful interventions include self-monitoring, incorporation of theory and behavior change techniques, and social and professional support.
Quality and Methodology of Clinical Practice Guidelines on Antiviral Pharmacotherapy for COVID-19 During the Early Phase of the Pandemic	Mejza,  Filip,  Lesniak, et al	Research Square prepub	Review Literature| Revue de littérature
Prevention and response to gender-based violence (GBV) during novel Covid-19 lock-down in Uganda	Nabukeera,  M	Journal of Adult Protection	Review Literature| Revue de littérature
Effect of SARS-CoV-2 Infection in Pregnancy on Maternal and Neonatal Outcomes in Africa: An AFREhealth Call for Evidence through Multicountry Research Collaboration	Nachega,  JB,  Sam-Agudu, et al	Am J Trop Med Hyg	Review Literature| Revue de littérature
The Potentially Recommended Pharmacotherapy for COVID-19	Nazir,  SUR,  Nazir, et al	Altern Ther Health Med	Review Literature| Revue de littérature
Impact of COVID-19 on adolescents’ mental health: a systematic review	Octavius,  GS,  Silviani, et al	Middle East Current Psychiatry	Review Literature| Revue de littérature	SR: systematic search was conducted from Cochrane, Google Scholar, Scielo, and PubMed. COVID-19 has been found to be associated with mental health changes in adolescents which meant management of COVID-19 should also focus on mental health as well.
Prone positioning for ARDS patients—tips for preparation and use during the COVID-19 pandemic	Parhar,  KKS,  Zuege, et al	Canadian Journal of Anesthesia	Review Literature| Revue de littérature
How our homes impact our health: using a COVID-19 informed approach to examine urban apartment housing	Peters,  T,  Halleran, et al	Archnet-IJAR	Review Literature| Revue de littérature
COVID-19, ferrosenescence and neurodegeneration, a mini-review	Sfera,  A,  Osorio, et al	Prog Neuropsychopharmacol Biol Psychiatry	Review Literature| Revue de littérature
Trained immunity as a novel approach against COVID-19 with a focus on Bacillus Calmette–Guérin vaccine: mechanisms, challenges and perspectives	Sohrabi,  Y,  Dos Santos, et al	Clinical and Translational Immunology	Review Literature| Revue de littérature
The Last Inches: Human Thermal Plume As An Overlooked Factor in Airborne Transmission of COVID-19 in the Human Microenvironment	Sun,  Shiyi,  Li, et al	SSRN- Lancet prepublication	Review Literature| Revue de littérature
Covid-19 compared with other viral diseases: Novelties, progress, and challenges	Wang,  L,  Alexander, et al	Electronic Journal of General Medicine	Review Literature| Revue de littérature
The Possible Intermediate Hosts of and the Transmission of SARS-CoV-2 Based on Data and Literature Analysis	Wang,  Z		Review Literature| Revue de littérature
First Chair Chats: Reflections on a Virtual Pilot Collaboration	Wolski,  K,  Feustle, et al	Music Reference Services Quarterly	Review Literature| Revue de littérature
A review of Corona Virus Disease 2019 (COVID-19)	Xie,  R		Review Literature| Revue de littérature
Coordinating and assisting research at the SARS-CoV-2/ microbiome nexus	Abdo,  Z,  Blaser, et al	mSystems	Commentary/Editorial| Commentaire/Éditorial
We’re Teaching IT All Wrong: A Need for Premortem Analysis in Hotel Strategy Education (and Practice)	Adriaanse,  J,  van der Rest, et al	Journal of Hospitality and Tourism Research	Commentary/Editorial| Commentaire/Éditorial
Tax policy measures to combat the sars-cov-2 pandemic and considerations to improve tax compliance: a behavioral perspective	Alm,  J,  Blaufus, et al	FinanzArchiv	Commentary/Editorial| Commentaire/Éditorial
Telehealth in the time of Corona: ‘doctor in the house’	Almallah,  YZ,  Doyle, et al	Internal Medicine Journal	Commentary/Editorial| Commentaire/Éditorial
Modalities to Disseminate Guidelines for Frontline Health Care Staff Safety for COVID-19	Baker,  TL,  Greiner, et al	Journal of Primary Care and Community Health	Commentary/Editorial| Commentaire/Éditorial
Legal scenarios in the coronavirus time: Medico legal implications in the aspects of governance	Bonvicini,  B,  Cecchi, et al	Leg Med (Tokyo)	Commentary/Editorial| Commentaire/Éditorial
Correction to: Incidence of thromboembolism in patients with COVID-19: a systematic review and meta-analysis	Boonyawat,  K,  Chantrathammachart, et al	Thromb J	Commentary/Editorial| Commentaire/Éditorial
Botanical drugs and supplements affecting the immune response in the time of COVID-19: Implications for research and clinical practice	Brendler,  T,  Al-Harrasi, et al	Phytother Res	Commentary/Editorial| Commentaire/Éditorial
"Excuse the cat…" Reflections on online mentoring during the COVID-19 pandemic	Browne,  J	Med Educ	Commentary/Editorial| Commentaire/Éditorial
Aesthetic medicine during COVD-19: patient perspectives and motivations amidst a pandemic	Burleigh,  A,  Beleznay, et al	J Cosmet Dermatol	Commentary/Editorial| Commentaire/Éditorial
Exploring the nexus between pandemics and natural capital: Covid-19 and other zoonoses	Calabrese,  G,  Bilali, et al	New Medit	Commentary/Editorial| Commentaire/Éditorial
Words Speak Louder Than Numbers: Estimating China’s COVID-19 Severity with Deep Learning	Chan,  Julian TszKin,  Ho, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Perspective on the sars-cov-2 and its diagnostic tests	Chatki,  PK,  Pise, et al	International Journal of Current Research and Review	Commentary/Editorial| Commentaire/Éditorial
Plague, pedagogy and pleasure: Creative interventions in higher education	Chemi,  T	Knowledge Cultures	Commentary/Editorial| Commentaire/Éditorial
Are Aspirin and Apixaban Sufficient to Prevent Immunothrombosis in COVID-19?	Chiang,  Kate,  Reddy, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Establishment of a hospital-based health care workers surveillance programme to keep them safe during the COVID-19 pandemic	Chong,  DWQ,  Jayaraj, et al	Journal of global health	Commentary/Editorial| Commentaire/Éditorial
Crisis, Collaboration, Recovery: IELTS and COVID-19	Clark,  T,  Spiby, et al	Language Assessment Quarterly	Commentary/Editorial| Commentaire/Éditorial
China's vaccine gambit: With its global campaign to test and promote COVID-19 vaccines, China aims to win friends and cut deals	Cohen,  J	Science	Commentary/Editorial| Commentaire/Éditorial
The Role of FDA CDER Statisticians in Response Efforts to the COVID-19 Pandemic	Collins,  SH,  Price, et al	Statistics in Biopharmaceutical Research	Commentary/Editorial| Commentaire/Éditorial
The Drum Must Beat On: COVID-19 and the U.S. Military's Virtual Health Response in Europe	Cornfeld,  LR,  Keen, et al	Telemed J E Health	Commentary/Editorial| Commentaire/Éditorial
Face masks and COVID-19: don't let perfect be the enemy of good	Cowling,  BJ,  Leung, et al	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin	Commentary/Editorial| Commentaire/Éditorial
Editorial 17.5. strengthening our focus for a post-covid-19 environment: Learnings from a pandemic in higher education	Crawford,  J,  Percy, et al	Journal of University Teaching and Learning Practice	Commentary/Editorial| Commentaire/Éditorial
Covid-19 and current implications on pediatric dentistry	Çubukçu,  ÇE	Guncel Pediatri	Commentary/Editorial| Commentaire/Éditorial
Co-Researching With Children in the Time of COVID-19: Shifting the Narrative on Methodologies to Generate Knowledge	Cuevas-Parra,  P	International Journal of Qualitative Methods	Commentary/Editorial| Commentaire/Éditorial
Government-led or Public-led? Chinese Policy Agenda Setting during the COVID-19 Pandemic	dai,  yixin,  Li, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Collaborative Filtering and Regression Techniques based location Travel Recommender System based on social media reviews data due to the COVID-19 Pandemic	Daya Sagar,  KV,  Arunasri, et al		Commentary/Editorial| Commentaire/Éditorial
Distinct phenotypes in COVID-19 may require distinct pulmonary rehabilitation strategies	De França,  EET,  Junior, et al	Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace	Commentary/Editorial| Commentaire/Éditorial
Research on Planning and Design of Resident-Friendly Community Parks: Taking the Huapu Park of Jinan City as an Example	Deyi,  K,  Cheng, et al		Commentary/Editorial| Commentaire/Éditorial
Brazil in the Face of COVID-19: Tragedy and Political Choices	Domingues,  JM	Environment	Commentary/Editorial| Commentaire/Éditorial
To be or not to be: negotiating leisure constraints with technology and data analytics amid the COVID-19 pandemic	Du,  J,  Floyd, et al	Leisure Studies	Commentary/Editorial| Commentaire/Éditorial
Race, police, and the pandemic: considering the role of race in public health policing	Dunbar,  A,  Jones, et al	Ethnic and Racial Studies	Commentary/Editorial| Commentaire/Éditorial
Airway management in patients with COVID-19: beyond the first endotracheal intubation	Figueiredo,  S,  Gaultier, et al	Anaesth Crit Care Pain Med	Commentary/Editorial| Commentaire/Éditorial
Report from…Wales The Ever After Project: considering theatre and performance in the era of Covid-19	Filmer,  A,  Brookes, et al	Theatre and Performance Design	Commentary/Editorial| Commentaire/Éditorial
Reply to: The effect of interventions on COVID-19	Flaxman,  S,  Mishra, et al	Nature	Commentary/Editorial| Commentaire/Éditorial
An ethic of care for people with disabilities during the covid-19 pandemic in China: Towards greater social justice	Fu,  W,  Deng, et al	Knowledge Cultures	Commentary/Editorial| Commentaire/Éditorial
Letter From a Covid-19 Survivor	Goisis,  PR	International Journal of Psychoanalysis	Commentary/Editorial| Commentaire/Éditorial
Mandating COVID-19 Vaccines	Gostin,  LO,  Salmon, et al	Jama	Commentary/Editorial| Commentaire/Éditorial
International higher education and global citizenship education: The rise of critical cosmopolitanism’s ‘personhood’ in the age of covid-19	Green,  B	Knowledge Cultures	Commentary/Editorial| Commentaire/Éditorial
When silence goes viral, Africa sneezes! A perspective on Africa's subdued research response to COVID-19 and a call for local scientific evidence	Gwenzi,  W,  Rzymski, et al	Environ Res	Commentary/Editorial| Commentaire/Éditorial
Covid-19 and re-opening of schools: Opinions with scientific evidence	Hacımustafaoğlu,  M	Turk Pediatri Arsivi	Commentary/Editorial| Commentaire/Éditorial
Digital placemaking and networked corporeality: Embodied mobile media practices in domestic space during Covid-19	Hardley,  J,  Richardson, et al	Convergence	Commentary/Editorial| Commentaire/Éditorial
Cracking the Code: COVID-19 and the Future of Professional Promises	Helmers,  A,  McCradden, et al	Am J Bioeth	Commentary/Editorial| Commentaire/Éditorial
Talk of the town in 2021: Covid-19 vaccines likely take centre stage	Höglund,  P	Scand J Immunol	Commentary/Editorial| Commentaire/Éditorial
Covid-19: The changing face of global citizenship and the rise of pandemic citizenship	Hollings,  S	Knowledge Cultures	Commentary/Editorial| Commentaire/Éditorial
Altered severity of the current sars-cov-2 in the kurdistan region of Iraq	Hussein,  S,  Qurbani, et al	Iranian Journal of Microbiology	Commentary/Editorial| Commentaire/Éditorial
COVID-19 reinfection - An enigmatic public health threat	Iyengar,  KP,  Jain, et al	Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace	Commentary/Editorial| Commentaire/Éditorial
The pragmatic nature of the virus and its biopolitical drive	Jiménez,  MA	Knowledge Cultures	Commentary/Editorial| Commentaire/Éditorial
Science and pseudoscience during the covid-19 pandemic	Kasapçopur,  Ö	Turk Pediatri Arsivi	Commentary/Editorial| Commentaire/Éditorial
A Crisis of Compromised Companionship in the Time of COVID-19	Kuhnel,  L	Am J Bioeth	Commentary/Editorial| Commentaire/Éditorial
The Centrality of Relational Autonomy and Compassion Fatigue in the COVID-19 Era	Lang,  KR,  Micah Hester, et al	Am J Bioeth	Commentary/Editorial| Commentaire/Éditorial
코로나19로 인한 고용충격의 양상과 정책적 시사점 (The COVID-19 Employment Shock and Policy Implications)	Lee,  Jongkwan	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Self-Defeating Codes of Medical Ethics and How to Fix Them: Failures in COVID-19 Response and Beyond	London,  AJ	Am J Bioeth	Commentary/Editorial| Commentaire/Éditorial
The importance of head and neck counselling in the COVID-19 era	Magaldi,  L,  Salzo, et al	Acta Otorhinolaryngol Ital	Commentary/Editorial| Commentaire/Éditorial
Evidence based education and effective teaching: How to integrate methodological and technological knowledge into teacher training	Marzano,  A,  Calvani, et al	Journal of Educational, Cultural and Psychological Studies	Commentary/Editorial| Commentaire/Éditorial
Rebuttal to Overinterpretation of the antiviral results for human coronavirus 229E (HCoV-229E) relative to severe acute respiratory syndrome coronavirus -2 (SARS-CoV-2) by Rowpar Pharmaceuticals	Meyers,  C,  Robison, et al	J Med Virol	Commentary/Editorial| Commentaire/Éditorial
Will we learn from covid-19? Ecopedagogical calling (un)heard	Misiaszek,  GW	Knowledge Cultures	Commentary/Editorial| Commentaire/Éditorial
Covid scholar-activism in miniature	Misiaszek,  L	Knowledge Cultures	Commentary/Editorial| Commentaire/Éditorial
Innovation intelligence and its role in environmental uncertainty management: a conceptual framework	Nobari,  N,  Mobini Dehkordi, et al	VINE Journal of Information and Knowledge Management Systems	Commentary/Editorial| Commentaire/Éditorial
Palmoplantar erythrodysesthesia: a diagnostic sign of COVID-19	Nuno-Gonzalez,  A,  Magaletsky, et al	Journal of the European Academy of Dermatology and Venereology	Commentary/Editorial| Commentaire/Éditorial
Exploring the Impact of Home-Schooling on the Psychological Wellbeing of Irish Families During the Novel Coronavirus (COVID-19) Pandemic: A Qualitative Study Protocol	O’Sullivan,  K,  McGrane, et al	International Journal of Qualitative Methods	Commentary/Editorial| Commentaire/Éditorial
English placement test of oral communication in times of COVID-19	Ockey,  GJ,  Muhammad, et al	Language Assessment Quarterly	Commentary/Editorial| Commentaire/Éditorial
On promoting breastfeeding of infants born to women with covid-19	Öncel,  S	Turk Pediatri Arsivi	Commentary/Editorial| Commentaire/Éditorial
Innovative Opportunities for Civility: Professional Development in a Time of COVID-19	Opsahl,  AG,  Embree, et al	J Contin Educ Nurs	Commentary/Editorial| Commentaire/Éditorial
Turkey's Battle with Covid-19: A Multifaceted Investigation	Öztürk,  AE,  Erkoc, et al	Middle East Policy	Commentary/Editorial| Commentaire/Éditorial
Data Science and Machine Learning Integrated Implementation Patterns for Cavernous Knowledge Discovery from COVID-19 Data	Prashanth,  B,  Neelima, et al		Commentary/Editorial| Commentaire/Éditorial
Expanding the toolbox to combat a pandemic	Prockop,  SE	Blood	Commentary/Editorial| Commentaire/Éditorial
Gerontological Social Work and COVID-19: Calls for Change in Education, Practice, and Policy from International Voices	Putnam,  M,  Shen, et al	Journal of Gerontological Social Work	Commentary/Editorial| Commentaire/Éditorial
Mechatronic Design and Robust Control of an Artificial Ventilator in Response to the COVID-19 Pandemic	Ramos-Paz,  S,  Belmonte-Izquierdo, et al		Commentary/Editorial| Commentaire/Éditorial
Covid-19 and disparities in education: Collective responsibility can address inequities	Reza,  F	Knowledge Cultures	Commentary/Editorial| Commentaire/Éditorial
Population Health Strategies to Support Hospital and Intensive Care Unit Resiliency During the COVID-19 Pandemic: The Italian Experience	Romani,  G,  Dal Mas, et al	Popul Health Manag	Commentary/Editorial| Commentaire/Éditorial
What COVID-19 tells us about the self: The deep intersubjective and cultural layers of our brain	Scalabrini,  A,  Xu, et al	Psychiatry and clinical neurosciences	Commentary/Editorial| Commentaire/Éditorial
Nursing Leadership Role Development: Preparing to Lead Through Ethical Conundrums	Scott,  M,  Bove, et al	J Contin Educ Nurs	Commentary/Editorial| Commentaire/Éditorial
China’s Leninist Response to COVID-19: From Information Suppression to Total Mobilization	Shih,  Victor	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Unexpected lessons from the COVID-19 lockdowns in France: Low impact of school opening on common communicable pediatric airborne diseases	Skurnik,  D,  Rybak, et al	Clin Infect Dis	Commentary/Editorial| Commentaire/Éditorial
The quiet earth: Re-functioning socio-material knowledge in the crisis of the pandemic	Snake-Beings,  E	Knowledge Cultures	Commentary/Editorial| Commentaire/Éditorial
The effect of interventions on COVID-19	Soltesz,  K,  Gustafsson, et al	Nature	Commentary/Editorial| Commentaire/Éditorial
“School of hard knocks” – what can mental health researchers learn from the COVID-19 crisis?	Sonuga-Barke,  E	Journal of Child Psychology and Psychiatry and Allied Disciplines	Commentary/Editorial| Commentaire/Éditorial
Can the COVID-19 pandemic boost the global adoption and usage of eHealth solutions?	Stanimirović,  D,  Matetić, et al	Journal of global health	Commentary/Editorial| Commentaire/Éditorial
Implications of the COVID-19 Pandemic for the Development and Update of Clinical Practice Guidelines: Viewpoint	Steeb,  T,  Follmann, et al	J Med Internet Res	Commentary/Editorial| Commentaire/Éditorial
Crisis is a Gateway to Censored Information: The Case of Coronavirus in China	Steinert-Threlkeld,  Zachary	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
The Information Technologies in the Control Mechanism of Medical Processes	Sultanovs,  E,  Strebko, et al		Commentary/Editorial| Commentaire/Éditorial
National Trends in the US Public's Likelihood of Getting a COVID-19 Vaccine-April 1 to December 8, 2020	Szilagyi,  PG,  Thomas, et al	Jama	Commentary/Editorial| Commentaire/Éditorial
Post-COVID-19 functional status six-months after Hospitalization.: Functional status after COVID-19	Taboada,  M,  Cariñena, et al	J Infect	Commentary/Editorial| Commentaire/Éditorial
ECO Friendly Mask Guide for Corona Prevention	Tumuluru,  PD,  Raju, et al		Commentary/Editorial| Commentaire/Éditorial
Immunized community and biopolitics in times of pandemic	Valle,  AM	Knowledge Cultures	Commentary/Editorial| Commentaire/Éditorial
In Science We Trust? Being Honest About the Limits of Medical Research During COVID-19	Veit,  W,  Brown, et al	Am J Bioeth	Commentary/Editorial| Commentaire/Éditorial
Temple University’s ITA Placement Test in Times of COVID-19	Wagner,  E,  Krylova, et al	Language Assessment Quarterly	Commentary/Editorial| Commentaire/Éditorial
Capital immunodeficiency and the viral contagion of capitalism	Wallin,  JJ,  Sandlin, et al	Knowledge Cultures	Commentary/Editorial| Commentaire/Éditorial
COVID-19 vaccine trial ethics once we have efficacious vaccines: Some placebo-controlled trials can continue ethically after a candidate vaccine is found to be safe and efficacious	Wendler,  D,  Ochoa, et al	Science	Commentary/Editorial| Commentaire/Éditorial
Tourism and the COVID-(Mis)infodemic	Williams,  NL,  Wassler, et al	Journal of Travel Research	Commentary/Editorial| Commentaire/Éditorial
Enabling cross-cultural student voice during covid-19: A collective autoethnography	Wilson,  S,  Tan, et al	Journal of University Teaching and Learning Practice	Commentary/Editorial| Commentaire/Éditorial
Crisis politics and US farm labor: health justice and Florida farmworkers amid a pandemic	Xiuhtecutli,  N,  Shattuck, et al	Journal of Peasant Studies	Commentary/Editorial| Commentaire/Éditorial
Methodology for sampling and detection of airborne coronavirus including SARS-CoV-2	Yun,  H,  Yang, et al	Indoor and Built Environment	Commentary/Editorial| Commentaire/Éditorial
When the big shots deviate: On the kap of religious clerics regarding prevention of covid-19 [letter]	Zehra,  SS,  Khalil, et al	Risk Management and Healthcare Policy	Commentary/Editorial| Commentaire/Éditorial
World Christianity and Mission 2021: Questions about the Future	Zurlo,  GA,  Johnson, et al	International Bulletin of Mission Research	Commentary/Editorial| Commentaire/Éditorial
Correction: Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project)		PLoS Med	Commentary/Editorial| Commentaire/Éditorial
2nd International Conference on Electronics Communication Technologies, ICECT 2020			Commentary/Editorial| Commentaire/Éditorial
International Conference on Recent Advancements in Engineering and Management, ICRAEM 2020 - Number 1			Commentary/Editorial| Commentaire/Éditorial
Correction to: Sociocultural, behavioural and political factors shaping the COVID-19 pandemic: the need for a biocultural approach to understanding pandemics and (re)emerging pathogens (GLOBAL PUBLIC HEALTH, (2020), 10.1080/17441692.2020.1828982)		Global Public Health	Commentary/Editorial| Commentaire/Éditorial
International Conference on Recent Advancements in Engineering and Management, ICRAEM 2020 - Number 2			Commentary/Editorial| Commentaire/Éditorial

Appendix: Process and definitions. 

A daily search for new publications is conducted in PubMed, Scopus, BioRxiv and MedRxiv, SSRN, Research Square, arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2 OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database.  The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google.  Publishers include Lancet, Elsevier, The New England Journal of Medicine, BMJ, Wiley, Springer Nature, ChinaCDCweekly. Additionally the database is cross-referenced with other literature scans and activities by collaborators.  Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa Waddell for additional information: Lisa.Waddell@canada.ca.  References are compiled in a reworks database that has citations since the beginning of the outbreak.  All references can be accessed at this link and by the categories listed below.  The daily scan has also been compiled in an excel sheet and copies can be provided upon request or accessed here.

Category Definitions:

Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely to influence future results.

Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro, attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*

Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.

Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.* 

Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.

Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers. 

Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data.  Surveillance data will likely be number of cases suspected/confirmed, number of deaths, number recovered. *

Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses

Diagnostics / Pathogen detection:  All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.

Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.

Vaccine Research:  Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.

Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.

Public Health interventions*: Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).

Public Health response: Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.

Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC

Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to:  set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.

Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.

Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)

Animal Model: An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the added risk of harming an actual human.

Zoonotic: all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.

Review Literature:  All articles that summarize the published literature can be tagged as a review.  This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*

Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary category.

News articles that have not scientific information.

*Lists are not exhaustive

Annexe: Processus et définitions. 

Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus, BioRxiv and MedRxiv, SSRN, Research Square, arXiv pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV).  La saisie renvoie à des annonces de publication sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google.  Parmi les éditeurs figurent Lancet, Elsevier, The New England Journal of Medicine, BMJ, Wiley, Springer Nature, ChinaCDCweekly.  En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.  Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au : Lisa.Waddell@canada.ca.  Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie.  Toutes les références sont accessibles à partir de ce lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées ici.

Définitions des catégories :

Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats. Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.

Épidémiologie : Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque, le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.

Transmission : Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.

Données cliniques des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.* 

Séquelles à long terme: Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.

Santé mentale: Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.

Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.  Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *

Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.

Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes, etc.

Thérapeutique : Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.

Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.

Priorités de santé publique : Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.

Interventions de santé publique* : Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).

Réponse de la santé publique : Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées à la pandémie.

Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) : Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.

Réponse des soins de santé : Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment :  mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux / stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.

Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)

Modèle animal: Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.

Zoonotic: all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.

Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19

Revue de la documentation :  Tous les articles qui résument les documents publiés peuvent être marqués comme une revue.  Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.

Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.

journaux Articles de presse qui n'ont pas d'informations scientifiques.

* Les listes ne sont pas exhaustives