Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-12-30

Good afternoon,

There are 1206 citations in today’s scan. 679 were considered primary research or review literature.

Highlights today include:

CANADA

· Schwartz et al described and compare the epidemiology, clinical characteristics, and lethality of SARS-CoV-2 infections among HCWs compared to non-HCWs in Ontario. Overall HCWs had an infection rate of 1,276 per 100,000 compared to non-HCWs of 346 per 100,000. This difference decreased from a 7 times higher rate in April to no difference in September 2020. Twenty-six percent of HCWs had a household member with SARS-CoV-2 infection; 6.8% were probable acquisitions, 12.3% secondary transmissions, and 6.9% unknown direction of transmission. The risk of death in HCWs remained significantly lower than non-HCWs after adjustment. 

· Kahlili et a conducted a Canadian cohort study of diabetic patients and reports that there was no statistical difference in mortality compared to controls. More severe pulmonary involvement (p=0.015), extended hospital stay (p<0.001) and greater need for invasive ventilation (p=0.029) were reported among the diabetic cases. Older age (odds ratio OR], 1.054; p=0.003), aggravated pulmonary involvement on admission (OR, 1.149; p=0.001), presence of comorbidities (OR, 1.290; p=0.020) and hypothyroidism (OR, 6.576; p=0.021) were associated with mortality. Diabetic foot infection had a strong positive correlation with mortality (OR, 49.819; p=0.016), whereas insulin therapy had a negative correlation (OR, 0.242; p=0.045).

PUBLIC HEALTH INTERVENTION

· Yang et al. estimate the effectiveness of two major non-pharmaceutical interventions—lockdown-like measures that reducing contact rates and universal masking in New York City. Lockdown-like measures were associated with >50% transmission reduction for all age groups. Universal masking was associated with a ∼7% transmission reduction overall and up to 20% reduction for 65+ year-olds during the first month of implementation.

· McDonald (preprint) describes a vaccine prioritization model for the USA that ranked demographic groups by risk of death from COVID-19.  They suggest that in the USA, vaccinating the highest risk groups (3.7% of the population) would prevent 47% of the deaths.

CORONAVIROLOGY

· Davies et al fitted a two-strain mathematical model of SARS-CoV-2 transmission and estimated that VOC 202012/01 is 56% more transmissible (95% CI across three regions 50-74%) than pre-existing variants of SARS-CoV-2. They were unable to find clear evidence that VOC 202012/01 results in greater or lesser severity of disease than pre-existing variants. The increase in transmissibility is likely to lead to a large increase in incidence, with COVID-19 hospitalisations and deaths projected to reach higher levels in 2021 than were observed in 2020.

· Andreano et al investigate the evolution of SARS-CoV-2 in the immune population by co-incubated authentic virus with a highly neutralizing plasma from a COVID-19 convalescent patient. After 80 days incubation, 2 naturally acquired mutations led to a variant completely resistant to plasma neutralization. SARS-CoV-2 has the potential to escape an effective immune response and that vaccines and antibodies able to control emerging variants should be developed.

· Konishi (preprint) describes an analysis of SARS-CoV-2 strains infecting humans in the Netherlands and shows that upto 40% of the human cases were infected with a mink-derived variant that was less lethan and infective compared to the human variant.  They also show that further mutated variants from mink were not identified in the human population.

· Kidd et al. present an analysis of new variant "S-dropout" samples from Birmingham University Turnkey laboratory part of the Lighthouse network responsible for testing clinical samples under the UK government ‘Test & Trace’ scheme. Based on our Qnostics EQA verification data for the TaqPath test, a Ct value of approximately 15-16 corresponds to a viral load of 1 x 10^6 copies per millilitre (mL). The observed cluster of S-dropout samples at Ct less than 15 corresponds to a conservative estimate of a significantly larger population of infectious subjects that have an increased viral load up to 10,000-fold higher. Such capability of increased transmission has been ascribed to an S ‘variant of concern’ spreading throughout the South-east of the UK, and possibly beyond; but epidemiologically the authors discuss the difficulties in disentangling other reasons for more efficient spread, such as human behavioural factors, from those of a clinical virological nature.

TRANSMISSION

· Port et al., demonstrate airborne transmission of SARS-CoV-2 to be efficient in Hamster models, than transmission from fomites. Airborne transmission was also dependent on the direction of the airflow. Fomite exposure led to milder disease manifestation characterized by an anti-inflammatory immune state and delayed shedding pattern. Early shedding was linked to an increase in disease severity.

CLINICAL DATA

· Bustos et al evaluated the association of viral load and severity of the disease. Fever, either as an exclusive symptom or combined with others, was associated with high viral loads. During the first week after onset of symptoms in mild patients up to 60 years‐old was detected the peak of viral load. Children under 10 years‐old have a high viral load in the first two days post‐infection with a sharp decline thereafter. Patients over 60 years‐old have high viral load up to the second week after the onset of symptoms, indicating the longer presence of the virus in them.

IMMUNOLOGY

· Reynolds et al analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection.

THERAPEUTICS

· Tahmasebi et al conducted a randomized, double‐blind, placebo‐controlled clinical trial to evaluate the therapeutic effects of nanocurcumin versus placebo. Curcumin could reduce the frequency of Th17 cells and their related inflammatory factors in both mild and severe COVID-19 patients.

HEALTHCARE RESPONSE

· Unroe et al provide insight into the willingness of front line staff to receive the vaccine as soon as it is available. Nursing home and assisted living facility staff in Indiana were surveyed and 45% of respondents indicated they would receive an approved COVID-19 vaccine as soon as available. Of those unwilling to take the vaccine when first available, 44% would consider in the future. Concerns about side effects was the primary reason for vaccine hesitancy (70%). Characteristics associated with increased willingness were age over 60, male, and white race.

Regards,

Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley Otten, Drew Greydanus, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark, Catherine Card, Ruey Su, Paul McLaren, Sandra Kiazyk, Nana Amankwah

Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news

Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance, Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI, Réponse des soins de santé, Immunologie, économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux

PUBLICATIONS	AUTHORS / AUTEURS	SOURCE	FOCI / DOMAINE	SUMMARY / SOMMAIRE
Knowledge, attitude, and precautionary measures towards covid-19 among medical visitors at the university of gondar comprehensive specialized hospital northwest Ethiopia	Abate,  H,  Mekonnen, et al	Infection and Drug Resistance	Public Health response| Interventions de santé publique	This study aimed to assess the knowledge, attitude, and precautionary measures of medical center visitors at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. The prevalence of poor knowledge, attitude, and precautionary measures was 42.2%, 39%, and 41.6%, respectively. Being female (AOR=2.79, 95% CI=1.752–4.44), divorced (AOR=0.29, 95% CI=0.09–0.88), and residing in a rural location (AOR=1.93, 95% CI=1.07–3.26) were significantly associated with poor knowledge. Being female (AOR=95%, CI=1.21–2.98), a farmer (AOR=4.13, 95% CI=1.60–10.63), residing in a rural location (AOR=2.53, 95% CI=1.31–4.88), poor knowledge (AOR=2.38, 95% CI=1.52–3.72), and negative attitude (AOR=3.25, 95% CI=2.07–5.09) were significantly associated with poor precautionary measures. Increasing income in one unit of Ethiopian birr (ETB) (AOR=0.26, 95% CI=0.031–0.051) was significantly associated with negative attitude.
COVIDX: Computer-aided diagnosis of Covid-19 and its severity prediction with raw digital chest X-ray images	Abbasi,  Wajid Arshad,  Abbas, et al	ArXiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	In this study, we present an automatic COVID-19 diagnostic and severity prediction (COVIDX) system that uses deep feature maps from CXR images to diagnose COVID-19 and its severity prediction. The proposed system uses a three-phase classification approach (healthy vs unhealthy, COVID-19 vs Pneumonia, and COVID-19 severity) using different shallow supervised classification algorithms.  In all the evaluation settings, COVIDX outperforms all the existing stateof-the-art methods designed for this purpose.
Macular Thickness and Volume Assessed by Spectral-Domain Optical Coherence Tomography in Patients With Coronavirus Disease 2019: A Case-Control Study	Abrishami,  Mojtaba,  Tohidinezhad, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques	To quantify the retinal thickness and volume using spectral-domain optical coherence tomography (SD-OCT) analysis in the macular region of patients with COVID-19. Twenty-five patients (11 male) with a mean age of 36.4 ± 11 years and 60 healthy controls (31 males) with a mean age of 39.3 ± 7.7 years were enrolled in the study. There was no statistically significant difference in the retinal thickness or volume measures between the two groups.
Patients with Rheumatic Diseases Overlooked during COVID-19 Pandemic: How are They Doing and how do They Behave?	Adnine,  A,  Soussan, et al	Curr Rheumatol Rev	Public Health response| Interventions de santé publique Healthcare Response | Réponse des soins de santé	We conducted this survey to learn about the real impact of COVID-19 pandemic on patients with rheumatic diseases. Patients had mostly moderate level of knowledge about COVID-19, and patients with higher level of education were more likely to have better knowledge. Participants respected mainly recommended preventive measures. The pandemic and sanitary containment impacted strongly the rheumatology care. Over quarter of patients noted worsening of their rheumatic disease, two-thirds reported postponed or canceled medical apointments and more than three quarters postponed their laboratory tests.
Continuous Glucose Monitoring in the Intensive Care Unit During the COVID-19 Pandemic	Agarwal,  S,  Mathew, et al	Diabetes care	Clinical data| Données cliniques	Study real-time continuous glucose monitoring (rtCGM) in 11 critically ill hospitalized COVID-19 patients. We analyzed inpatient CGM accuracy using point-of-care (POC) glucose-CGM matched pairs and included patients for analysis regardless of clinical status. In this real-world preliminary analysis of rtCGM during critical illness, we demonstrate early feasibility, considerable accuracy, and meaningful reduction in the frequency of POC glucose testing.
Duodenal perforation in a SARS-CoV-2-positive patient with negative PCR results for SARS-CoV-2 in the peritoneal fluid	Agnes,  A,  Greca, et al	European review for medical and pharmacological sciences	Clinical data| Données cliniques	We describe a SARS-CoV-2-positive patient with severe respiratory syndrome treated with multiple doses of IL-6 inhibitors who presented with a perforated duodenal ulcer and underwent emergency surgery. The first implication of this case is that the relation between repeated administration of IL-6 inhibitors and upper gastrointestinal bleeding and perforation must be investigated, and that the threshold for administering prophylactic proton pump inhibitors therapy should be carefully considered for patients with severe COVID-19. The second implication is that further testing should be performed on the peritoneal fluid of COVID-19 patients undergoing emergency surgical procedures to clarify the discordant results for the presence of SARSCoV-2 in the peritoneal cavity and the possible risk of transmission to the surgical staff.
Does COVID-19 Testing Create More Cases? An Empirical Evidence on the Importance of Mass Testing During a Pandemic	Ahmed,  Ali	medRxiv	Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	In this research, we used a dataset from the U.S. Department of Health & Human Services and empirically showed that by increasing the COVID-19 testing in the U.S., the spread of the COVID-19 decreased significantly. Our results indicate a negative relationship between the number of positive cases and the number of tests performed in the past months. The large-scale testing may have helped identify positive and asymptomatic cases early in the course of illness, which enabled individuals to isolate themselves, thus reducing the chances of spreading the diseases and slowing the spread of the pandemic.
PMC7756178; Do COVID-19 cases follow a similar transition path? Evidence from Indian states	Akram,  V,  Rath, et al	MethodsX	Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de santé publique	This paper assesses the convergence of COVID-19 cases by obtaining transition paths of Indian states covering the period from August 01 to October 31, 2020. The results based on Phillips-Sul test show evidence of different transition paths. These findings are useful from the policy perspective, particularly to see whether existing efforts made for stopping the spread of COVID-19 by states/central governments are effective.
Containment measures established during the COVID-19 outbreak and its impact on lipid profile and neutrophil to lymphocyte ratio	Aladağ,  N,  Şipal, et al	European review for medical and pharmacological sciences	Healthcare Response | Réponse des soins de santé	We aimed to evaluate lipid profile, neutrophil to lymphocyte ratio (NLR) and cardiovascular admissions to the coronary care unit (CCU) of a tertiary center in Turkey during the COVID-19 era and to compare these results with admissions in the same time interval of the previous year. Compared to the same time interval of 2019 (March-April, 2019), the number of patients admitted to the CCU with acute cardiovascular disorders (atrial fibrillation, STEMI, NSTEACS and acute heart failure) were lower in the COVID-19 period.
Predictors associated with COVID-19 deaths in Ethiopia	Alemu,  Y	Risk Management and Healthcare Policy	Epidemiology| Épidémiologie Clinical data| Données cliniques	The purpose of this investigation was to identify the determinants of COVID-19 deaths in Ethiopia. Among 468,814 total tests, 9,027 were recovered, 20,900 were confirmed cases, and 365 were deaths from coronavirus diseases in Ethiopia. Critical cases (β= 0.570, p= 0.006) and average temperature (β= −35.061, p= 0.003) variables were statistically significant. Critical or serious cases significantly and positively affected the deaths from this pandemic disease, while the average temperature significantly and negatively affected the deaths from COVID-19 disease in Ethiopia.
A Synthetic Control Method Analysis of Schools Opening and COVID-19 Outbreak in Italy	Alfano,  Vincenzo,  Ercolano, et al	SSRN- Lancet prepublication	Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	By the means of a quantitative analysis that exploits the quasi experimental setting offered by the scattered opening that schools have had in Italy, we investigate if open schools favour the spread of the virus. A synthetic control method approach suggests that Bolzano, the first province in Italy to have opened the schools after the summer break, has way more cases than its synthetic counterfactual, built from a donor pool constituted by the other Italian provinces. Results seem to confirm that that opening the schools causes and increase in the infections, and this has to be taken into account by the policymakers.
Clinical characteristics of asymptomatic and symptomatic COVID-19 patients in the Eastern Province of Saudi Arabia	AlJishi,  JM,  Alhajjaj, et al	Journal of Infection and Public Health	Epidemiology| Épidémiologie Clinical data| Données cliniques	We describe the clinical characteristics of the initial COVID-19 patients in Qatif. From March 1st, 2020 to April 5th, 2020 we identified a total of 82 adult COVID-19 patients. The median age of the patients was 50 years, with a range of 30 to 60 years and most of patients were female 54 (65.9%). Of all the patients, 29 (35.4%) were contacts and 43 (52.4%) were returning travelers, mainly from Iraq (65% of the total returning travelers). Comorbidities were present in 50% of patients, G6PD deficiency in 33%, hypertension in 27%, and diabetes mellitus in 26%. Chest radiographs were abnormal in 46% of symptomatic and 15.5% of asymptomatic patients (P value = 0.0035). Of all patients, 4 (4.87%) required intensive care admission. There was no significant difference in time to negative RT-PCR with mean days to negativity of 13.6 and 16.9 for asymptomatic and symptomatic group, respectively (P value = 0.42).
Association of substance use disorders and drug overdose with adverse COVID-19 outcomes in New York City: January-October 2020	Allen,  B,  El Shahawy, et al	J Public Health (Oxf)	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study investigated risks of severe COVID-19 among patients with substance use disorder (SUDs). Of patients tested for COVID-19 (n = 188 653), 2.7% (n = 5107) had any history of SUD. Associations with hospitalization AORs (95% confidence interval)] ranged from 1.78 (0.85-3.74) for cocaine use disorder (COUD) to 6.68 (4.33-10.33) for alcohol use disorder. Associations with ICU admission ranged from 0.57 (0.17-1.93) for COUD to 5.00 (3.02-8.30) for overdose. Associations with death ranged from 0.64 (0.14-2.84) for COUD to 3.03 (1.70-5.43) for overdose.  Patients with histories of SUD and drug overdose may be at elevated risk of adverse COVID-19 outcomes.
Lung ultrasound for point-of-care COVID-19 pneumonia stratification: Computer-aided diagnostics in a smartphone. First experiences classifying semiology from public datasets	Almeida,  A,  Bilbao, et al		Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	We explore computer-aided diagnostics of pneumonia semiology based on light-weight neural networks (MobileNets). For proof-of-concept, multi-task learning is performed from online available COVID-19 datasets, for which semiology (overall abnormality, B-lines, consolidations and pleural thickening) is annotated by two radiologists. Initial results suggest that individual indications can be classified with good performance in a smartphone. Neural networks may also help to reduce inter-reader variability and objectivize LUS interpretation, especially for early-stage pathological indications.
Prediction of potential inhibitors against SARS-CoV-2 endoribonuclease: RNA immunity sensing	Al-Rashedi,  N,  Munahi, et al	J Biomol Struct Dyn	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	This study aimed to identify drugs that targeted SARS-COV-2 Nsp15 using a molecular docking-based virtual screening of a library containing 10,000 approved and experimental drugs. The molecular docking results revealed 19 medications that demonstrated a good ability to inhibit Nsp15. Among all the candidated 19 drugs only five FDA approved drugs were used for further investigation by molecular dynamics simulation, the stability of Nsp15-ligand system was evaluated by calculating the RMSD, RMSF, radius of gyration and hydrogen bond profile. Furthermore, MM-PBSA method was employed to validate the binding affinity. According to the obtained results of MD, the complex of Olaparib was showed more stability and lower binding free energy than the control inhibitor during MD simulation time. Finally, we suggest that Olaparib is a potential drug for treating patients infected with SARS-CoV-2 and provide insight into the host immune response to viral RNA.
Queuing Safely for Elevator Systems Amidst a Pandemic	Ananthanarayanan,  Sai Mali,  Branas, et al	SSRN- Lancet prepublication	Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de santé publique	The objective of this study was to propose simple interventions for safely managing the elevator queues that drastically reduce the waiting time and length of lobby queues. We use mathematical modeling, epidemiological principles, and simulation to design and evaluate our interventions. Based on simulation studies, Cohorting and Queue Splitting can significantly reduce queue length and wait time, while also maintaining safety from viral transmission in otherwise crowded elevators, building lobbies, and entrances.
SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma	Andreano,  Emanuele,  Piccini, et al	bioRxiv	Coronavirology| Coronavirologie Immunology | Immunologie	To investigate the evolution of SARS-CoV-2 in the immune population, we co-incubated authentic virus with a highly neutralizing plasma from a COVID-19 convalescent patient. The plasma fully neutralized the virus for 7 passages, but after 45 days, the deletion of F140 in the spike N-terminal domain (NTD) N3 loop led to partial breakthrough. At day 73, an E484K substitution in the receptor-binding domain (RBD) occurred, followed at day 80 by an insertion in the NTD N5 loop containing a new glycan sequon, which generated a variant completely resistant to plasma neutralization. Computational modeling predicts that the deletion and insertion in loops N3 and N5 prevent binding of neutralizing antibodies. The recent emergence in the United Kingdom and South Africa of natural variants with similar changes suggests that SARS-CoV-2 has the potential to escape an effective immune response and that vaccines and antibodies able to control emerging variants should be developed.
COvid-19 and high-dose VITamin D supplementation TRIAL in high-risk older patients (COVIT-TRIAL): study protocol for a randomized controlled trial	Annweiler,  C,  Beaudenon, et al	Trials	RCT	Clinical trial proposal. Aim of this trial is to compare the effect of a single oral high dose of cholecalciferol versus a single oral standard dose on all-cause 14-day mortality rate in COVID-19 older adults at higher risk of worsening. The COVIT-TRIAL study is an open-label, multicenter, randomized controlled superiority trial. Patients aged ≥ 65 years with COVID-19 (diagnosed within the preceding 3 days) and at least one worsening risk factor at the time of inclusion, having no contraindications to vitamin D supplementation, and having received no vitamin D supplementation > 800 IU/day during the preceding month are recruited. Participants are randomized either to high-dose cholecalciferol or to standard-dose cholecalciferol. The primary outcome measure is all-cause mortality within 14 days of inclusion. Secondary outcomes are the score changes on the World Health Organization Ordinal Scale for Clinical Improvement (OSCI) scale for COVID-19, and the between-group comparison of safety. These outcomes are assessed at baseline, day 14, and day 28, together with the serum concentrations of 25(OH)D, creatinine, calcium, and albumin at baseline and day 7.
Predictive models for cumulative confirmed COVID-19 cases by day in Southeast Asia	Areepong,  Y,  Sunthornwat, et al	CMES - Computer Modeling in Engineering and Sciences	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	Investigated the suitable forecasting model for the number of infectious people in Southeast Asian countries. The estimation of parameters of the forecasting models is evaluated by the least square method. In addition, spreading of the outbreak is estimated by the derivative of the number of cumulative cases. The findings show that Gompertz growth curve is a suitable forecasting model for Indonesia, Philippines, and Malaysia and logistic growth curve suits the other countries in South Asia.
Assessing the impact of covid-19 on the mental health of healthcare workers in three metropolitan cities of pakistan	Arshad,  MS,  Hussain, et al	Psychology Research and Behavior Management	Mental Health | santé mentale	Assessed the mental health of healthcare workers (HCWs) in the three metropolitan cities of Pakistan from April to June 2020. The frequency of depression, anxiety, and stress (DAS) in the HCWs was 10.1%, 25.4%, and 7.3%, respectively. The Multivariable logistic regression analysis (MLRA) showed that the depression in HCWs was significantly associated with the profession (P<0.001). The anxiety in HCWs was significantly associated with their age (P=0.005), profession (P<0.05), and residence (P<0.05). The stress in HCWs was significantly associated with their age (P<0.05).
Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L	Ashhurst,  AnnelieseS,  Tang, et al	bioRxiv	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is recognized as a promising drug target. The marine natural product, gallinamide A and several synthetic analogues, were identified as potent inhibitors of cathepsin L activity with IC50 values in the picomolar range. Lead molecules possessed selectivity over cathepsin B and other related human cathepsin proteases and did not exhibit inhibitory activity against viral proteases Mpro and PLpro. We demonstrate that gallinamide A and two lead analogues potently inhibit SARS-CoV-2 infection in vitro, with EC50 values in the nanomolar range, thus further highlighting the potential of cathepsin L as a COVID-19 antiviral drug target.
METHODOLOGICAL PROPOSAL FOR THE AMBULATORY DETECTION OF COVID-19 SYMPTOMS, USING LOW-COST DEVICES	Auccahuasi,  W,  Linares, et al	PalArch's Journal of Archaeology of Egypt/ Egyptology	Clinical data| Données cliniques Public health interventions*| Interventions de sant&amp;eacute; publique	Evaluated low-cost devices to analyze heart rhythm, blood pressure, and oxygen saturation as alert mechanisms for possible COVID-19 symptoms. The results show that wearable devices in the form of a watch are widely used to control people's movements, the exercises they perform, the proposed methodology consists of a device that has the ability to evaluate these three biomedical variables, it is not necessarily a medical device with a high degree of sensitivity or accuracy. The usefulness of the device is to be able to carry out a quick analysis that helps people make a decision.
PMC7640888; Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer	Avanzato,  VA,  Matson, et al	Cell	Clinical data| Données cliniques Long-Term Sequelae | séquelles à long terme Coronavirology| Coronavirologie	Long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding was observed from the upper respiratory tract of a female immunocompromised individual with chronic lymphocytic leukemia and acquired hypogammaglobulinemia. Shedding of infectious SARS-CoV-2 was observed up to 70 days, and of genomic and subgenomic RNA up to 105 days, after initial diagnosis. The infection was not cleared after the first treatment with convalescent plasma, suggesting a limited effect on SARS-CoV-2 in the upper respiratory tract of this individual. Several weeks after a second convalescent plasma transfusion, SARS-CoV-2 RNA was no longer detected. We observed marked within-host genomic evolution of SARS-CoV-2 with continuous turnover of dominant viral variants. However, replication kinetics in Vero E6 cells and primary human alveolar epithelial tissues were not affected. Our data indicate that certain immunocompromised individuals may shed infectious virus longer than previously recognized. Detection of subgenomic RNA is recommended in persistently SARS-CoV-2-positive individuals as a proxy for shedding of infectious virus.
Predicting COVID-19 incidence through analysis of Google trends data in Iran: Data mining and deep learning pilot study	Ayyoubzadeh,  SM,  Ayyoubzadeh, et al	JMIR Public Health and Surveillance	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	Aimed to predict the incidence of COVID-19 in Iran using data from Google Trends. The linear regression model predicted the incidence with an root mean square error (RMSE) of 7.562 (SD 6.492). The most effective factors besides previous day incidence included the search frequency of handwashing, hand sanitizer, and antiseptic topics. The RMSE of the LSTM model was 27.187 (SD 20.705).
Performance of low-dose chest ct scan for initial triage of covid-19	Bahrami-Motlagh,  H,  Darazam, et al	Iranian Journal of Radiology	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Evaluated the diagnostic efficacy of low-dose chest CT versus early RT-PCR results, for triage of COVID-19 patients. Of 163 patients, 54.6% were presented with positive initial RT-PCR result. Lymphocyte percentage and lymphocyte count were significantly lower in the positive RT-PCR group (15% versus 19%, and 0.98 vs. 1.3, respectively); while, erythrocyte sedimentation rate (ESR) was significantly higher (53 vs. 22). Positive chest CT findings were present in 81.6%. The sensitivity, specificity, positive and negative predictive values (PPV and NPV) and accuracy of low-dose chest CT scan were 96.6%, 36.5%, 64.7%, 90% and 69.3%, respectively based on positive RT-PCR results.
Social Distancing During a Pandemic: The Role of Friends	Bailey,  Michael,  Johnston, et al	SSRN- Lancet prepublication	Public Health response| Interventions de santé publique	We explore how social network exposure to COVID-19 cases shapes individuals’ social distancing behavior during the early months of the ongoing pandemic. We work with de-identified data from Facebook to show that U.S. users whose friends live in areas with worse coronavirus outbreaks reduce their mobility more than otherwise similar users whose friends live in areas with smaller outbreaks. The effects are quantitatively large: a one standard deviation increase in friendexposure to COVID-19 cases early in the pandemic results in a 1.2 percentage point increase in the probability that an individual stays home on a given day. As the pandemic progresses, changes in friend-exposure drive changes in social distancing behavior. Given the evolving nature and geography of the pandemic—and hence friend-exposure — these results rule out many alternative explanations for the observed relationships. We also analyze data on public posts and membership in groups advocating to “reopen” the economy to show that our findings can be explained by friend-exposure raising awareness about the risks of the disease and inducing individuals to participate in mitigating public health behavior.
Splitting teams at a hospital pharmaceutical care services during COVID-19 pandemic: A tertiary hospital experience in Saudi Arabia	Bakhsh,  H,  Makki, et al	Journal of Microscopy and Ultrastructure	Healthcare Response | Réponse des soins de santé	Provide guidance on minimizing pharmacy staff at risk of COVID-19 exposure and serve as emergency preparedness in case of mass staff infected with COVID-19 pandemic within the department. A total of 119 electronic surveys were distributed to the pharmacy staff and responded by 102 pharmacists and pharmacy technicians. All the study participants agreed on two group system which includes working-week-week-off. However, only three participants chose a full-team monthly roster. All participants agreed to be ready for work in their week-off as on demand. Furthermore, they all agreed to strictly follow the preventive measures of wearing masks and physical distancing. Furthermore, they gave permission to the administration to review the working schedule every 2 weeks to either continue the same way or to back to the full-team scheduled monthly roster.
Two-step strategy for the identification of SARS-CoV-2 variants co-occurring with spike deletion H69-V70, Lyon, France, August to December 2020	Bal,  Antonin,  Destras, et al	medRxiv	Clinical data| Données cliniques Coronavirology| Coronavirologie	Report the implementation of a two-step strategy enabling to detect SARS-CoV-2 variants carrying H69-V70 deletion. We found that this deletion resulted in a false negative result for the spike target of a three-target RT-PCR assay (TaqPath kit). From August 3rd to December 20th, 59/9,266 (0.6%) of positive tests displayed a S negative profile (negative for S target and positive for N & ORF1ab targets). Among the 59 samples without detection of the S target, 36 were available for whole genome sequencing (WGS). The most frequent S mutations co-occurring with ΔH69/ΔV70 were S477N & D614G (21/36 samples). The co-occurrence of N439K and D614G mutations was found in 10/36 samples. The complete combination of S mutations detected in VUI 202012/01 or in cluster-5 variant was not found. The data presented herein emphasize that the TaqPath RT-PCR assay enables a rapid, large-scale screening of ΔH69/ΔV70 variants. Samples with S negative profiles should be further addressed to national referral laboratories for SARS-CoV-2 WGS.
The Psychological Impact Analysis of Novel COVID-19 Pandemic in Health Sciences Students: A Global Survey	Bashir,  TF,  Hassan, et al	Eur J Dent	Mental Health | santé mentale	Evaluated the anxiety and depression amid novel coronavirus disease-19 (COVID-19) pandemic in health sciences students around the globe. Among the 523 participants, 69.55% students were from developing countries and 30.21% from developed countries; 81.1% students were tested negative for COVID-19 and 18.9% had suffered from severe acute respiratory syndrome coronavirus 2 infection during pandemic. The mean Generalized Anxiety Disorder (GAD)-7 and Patient Heath Questionnaire (PHQ)-9 scores were 7.16 ± 5.755 and 7.30 ± 6.166, respectively. Significant impact on anxiety levels was associated with age, gender, education status, and COVID-19 positive patient, while depression was not significantly associated with gender, COVID-19, and its reported symptoms in participants.
Salivary SARS-CoV-2 antigen rapid detection: a prospective cohort study	Basso,  Daniela,  Aita, et al	medRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Compared the diagnostic performance of salivary and naso-pharyngeal swab (NPS) SARS-CoV-2 antigen detection by a rapid chemiluminescent assay (CLEIA) and two different point-of-care (POC) immunochromatographic assays, with that of molecular testing. The overall agreement between NPS and saliva rRT-PCR was 78.7%, reaching 91.7% at the first week from symptoms onset. SARS-CoV-2 CLEIA antigen was highly accurate in distinguishing between positive and negative NPS (ROC-AUC=0.939), with 81.6% sensitivity and 93.8% specificity. This assay on saliva had an overall good accuracy (ROC-AUC=0.805), reaching the optimal value within 7 days from symptom onset (Sensitivity: 72%; Specificity: 97%). POC antigen in saliva had a very limited sensitivity (13%), performing better in NPS (Sensitivity: 48% and 66%; Specificity: 100% and 99% for Espline and Abbott respectively), depending on viral loads.
Timely Tracking of Infection Status of Individuals in a Population	Bastopcu,  Melih,  Ulukus, et al	ArXiv	Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de sant&amp;eacute; publique	We consider real-time timely tracking of infection status (e.g., covid-19) of individuals in a population. In this work, a health care provider wants to detect infected people as well as people who recovered from the disease as quickly as possible. In order to measure the timeliness of the tracking process, we use the long-term average difference between the actual infection status of the people and their real-time estimate by the health care provider based on the most recent test results. We first find an analytical expression for this average difference for given test rates, and given infection and recovery rates of people. Next, we propose an alternating minimization based algorithm to minimize this average difference. We observe that if the total test rate is limited, instead of testing all members of the population equally, only a portion of the population is tested based on their infection and recovery rates. We also observe that increasing the total test rate helps track the infection status better. In addition, an increased population size increases diversity of people with different infection and recovery rates, which may be exploited to spend testing capacity more efficiently, thereby improving the system performance. Finally, depending on the health care provider's preferences, test rate allocation can be altered to detect either the infected people or the recovered people more quickly.
High SARS-COV2 IgG/IGM seroprevalence in asymptomatic Congolese in Brazzaville, the Republic of Congo	Batchi-Bouyou,  A,  Lobaloba, et al	Int J Infect Dis	Epidemiology| Épidémiologie Immunology | Immunologie	Evaluated the incidence of SARS-CoV-2 within the population through a seroprevalence study on healthy individuals from different districts of Brazzaville in the Republic of Congo. Out of 754 samples, 56 were found to have active SARS-COV2 infection and 117 had detectable anti-SARS-CoV-2 antibodies in their serum. Among the RT-PCR negative subjects, the seroprevalence raised from 1.7% for IgG+ and 2.5% for IgM+ in April to 14.2% of IgG and 17.6% of IgM in July. No difference was found according to the district of residence (P=0.108). With regard to gender, 5% of women against 0% of men had either IgG and IgM in April. During the first three months, seroprevalence was significantly higher in women within IgG (P˂0.0001) and IgM (P˂0.001).
Drug designing against NSP15 of SARS-COV2 via high throughput computational screening and structural dynamics approach	Batool,  A,  Bibi, et al	European journal of pharmacology	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Propose promising drug candidates against the newly identified potential therapeutic target (endonuclease, NSP15) of SARS-CoV2.  Integrated the high throughput computational screening and dynamic simulation approach to identify the most promising candidate lead compound against NSP15. Favipiravir, remedesivir, ritonavir, oseltamivir, and lopinavir were chosen as a training set to generate the pharmacophore model. A dataset of ~140,000 compounds library was screened against the designed pharmacophore model and 10 unique compounds were selected that passed successfully through geometry constraints, Lipinski Rule of 5, and ADME/Tox filters along with a strong binding affinity for NSP15 binding cavity. Given our detailed integrative computational analysis, a Small molecule (3,3-Dimethyl-N-4-(1-piperidinylcarbonyl) phenyl] butanamide) with drug-like properties and high binding affinity with the NSP15 is proposed as a most promising potential drug against COVID-19.
Role of the Health System in Combating Covid-19: Cross-Section Analysis and Artificial Neural Network Simulation for 124 Country Cases	Bayraktar,  Y,  Özyılmaz, et al	Soc Work Public Health	Healthcare Response | Réponse des soins de santé	Discuss the role of the health system in the fight against Covid-19. The number of hospital beds, the number of doctors, life expectancy at 60, universal health service and the share of health expenditures in GDP were used as health indicators. In the study, 2020 data was estimated by using the Artificial Neural Networks simulation method and this year was used in the analysis. The model, with the data of 124 countries, was estimated using the cross-sectional OLS regression method. The estimation results show that the number of hospital beds, number of doctors and life expectancy at the age of 60 have statistically significant and positive effects on the ratio of Covid-19 recovered/cases. Universal health service and share of health expenditures in GDP are not significant statistically on the cases and recovered. Hospital bed capacity is the most effective variable on the recovered/case ratio.
An Artificial Intelligence Based Technique for COVID-19 Diagnosis from Chest X-Ray	Bekhet,  S,  Hassaballah, et al		Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The COVID-19 pandemic had a catastrophic impact on world health and economic. This is attributed to the unavoidable delay in the diagnosis process, due to limitation of COVID-19 test kits. Thus, it is urgently required to establish more cheap and affordable diagnostic approaches. Chest X-ray is an important initial step towards a successful COVID-19 diagnose, where it is easily to detect any chest abnormalities (e.g., lung inflammation). Furthermore, majority of hospitals have X-ray devices that can be used in early COVID-19 diagnosis. However, the shortage of radiologists is a key factor that limits early COVID-19 diagnosis and negatively affects the treatment process. This paper presents an artificial intelligence based technique for early COVID-19 diagnosis from chest X-ray images using medical knowledge and deep Convolutional Neural Networks (CNNs). To this end, a deep learning model is built carefully and fine-tuned to achieve the maximum performance in COVID-19 detection. Experimental results on recent benchmark datasets demonstrate the superior performance of the proposed technique in identifying COVID-19 with 96% accuracy. © 2020 IEEE.
Development of a novel risk score for the prediction of critical illness amongst COVID-19 patients	Bellos,  I,  Lourida, et al	International journal of clinical practice	Epidemiology| Épidémiologie Clinical data| Données cliniques	Evaluated the clinical and laboratory characteristics of hospitalised COVID-19 patients and construct a predictive model for the discrimination of patients at risk of disease progression. From a total of 67 patients 15 progressed to critical illness. The risk score included patients’ gender, presence of hypertension and diabetes mellitus, fever, shortness of breath, serum glucose, aspartate aminotransferase, lactate dehydrogenase, C-reactive protein and fibrinogen. Its predictive accuracy was estimated to be high (area under the curve: 97.1%), performing better than CURB-65, CRB-65 and PSI/PORT scores. Its sensitivity and specificity were estimated to be 92.3% and 93.3%, respectively, at the optimal threshold of 1.6.
Dynamics of the epidemic process and the course of the COVID-19 in pregnant women of the Far Eastern and Siberian Federal Districts	Belokrinitskaya,  TE,  Artymuk, et al	Gynecology	Epidemiology| Épidémiologie Clinical data| Données cliniques	Evaluated epidemiological characteristic and the course of COVID-19 in pregnant women from the Far East and Siberian Federal Districts of Russia. On August 25, 2020, 2010 cases of COVID-19 in pregnant women were detected in two subjects, including 134 active cases. In the population, the proportion of pregnant women among cases of COVID-19 was 1.45%. Pneumonia in pregnant women was registered in 44.8% of cases, severe course of the disease in 37%, hospitalization in RAW in 1.9% of cases, mechanical ventilation 0%. In the population, pneumonia was registered in 24.4% of cases, hospitalized in RAW 2.1%, on mechanical ventilation 0.77%. The incidence in pregnant women was 1464.7 per 100 000 (in the population 591.8 per 100 000). 23 COV1D-19 (+) newborns were identified, despite preventive measures and separation of mother and child immediately after childbirth, which does not exclude vertical transmission of the disease. Maternal mortality was 0.1% cases vs population mortality 1.49%. Perinatal mortality was 0.35% cases. There were 5 stillbirths. Early neonatal mortality was 0.1% cases.
MHC Haplotyping of SARS-CoV-2 patients: HLA subtypes are not associated with the presence and severity of Covid-19 in the Israeli population	Ben Shachar,  Shay,  Barda, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	Conducted a large scale HLA analysis of Israeli individuals who tested positive for SARS-CoV-2 infection by PCR. Overall, 72,912 individuals with known HLA haplotypes were included in the study, of whom 8.8% were found to have SARS-CoV-2 by PCR. A total of 20,937 subjects were of Ashkenazi origin (at least 2/4 grandparents). 2.8% of the infected were hospitalized due to the disease. None of the 66 most common HLA loci (within the five HLA subgroups; A, B, C, DQB1, DRB1) was found to be associated with SARS-CoV-2 infection or hospitalization. Similarly, no association was detected in the Ashkenazi Jewish subset. Moreover, no association was found between heterozygosity in any of the HLA loci and either infection or hospitalization
A pandemic response to home delivery for ambulatory ECG monitoring: Development and validation	Benjamin,  H,  Bischof, et al	Journal of electrocardiology	Healthcare Response | Réponse des soins de santé	In response to the COVID-19 pandemic, a protocol was designed for mail-out devices and educational materials created to teach patients how to install a device for 2 weeks of continuous ambulatory ECG monitoring. We compared data collection from two sequential patient populations; one who received standard device application in the same clinic in the months before the pandemic response, and another, who received their device by mail for self-installation. Patients received a single phone call when the device was mailed and were able to contact the manufacturer as needed for support. A total of 47 devices were assessed from each group. Each group was similar in age (70 vs 65 years), and clinical indication for monitoring. Noise signal magnitude (22.34 vs 26.28%), symptom based manual activation (10 vs 8 events) and APB/recorded hour burden measurements (37.05 vs 23.36%) were similar in both groups (all comparisons were statistically non-significant). Both groups had a similar mean of hours recorded (240.37 vs. 245.05 h). Zero patient kits were lost, and all reports were delivered. Overall, it was found that a mail-delivered home-based recording platform can be reliably used to acquire clinical data with similar data quality and patient compliance as a conventional in-clinic model for long term ambulatory ECG monitoring. © 2020 Elsevier Inc.
Social Distancing and the Effects of COVID-19 Pandemic: A Study of the Six Regions of the World	Benjamin,  Oluwasegun,  Jimoh, et al	SSRN- Lancet prepublication	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique Economics | Économie	Reviewed the health, social and economic impact of coronavirus to estimate its prevalence and incidence rates and evaluate the policy responses with emphasis on the six regions of the world. Findings revealed that COVID-19 has not only threatened the lives of the people economically but also the national prosperity and social life of the people. Further, many countries still have a long way to go, as the curve of the incidence rate is far from reaching its peak.
Persistence of SARS-CoV-2 antibodies in kidney transplant recipients	Benotmane,  I,  Gautier Vargas, et al	Am J Transplant	Clinical data| Données cliniques	Describe the 6-month evolution of SARS-CoV-2 antibodies in an immunocompromised population. 20.7% of the study patients became seronegative, 72.4% were found to display anti-SARS-CoV-2 antibodies up to six months after COVID-19.
Thoughts of death, depression, and guilt in a healthcare worker who infected her husband with SARS-CoV-2: A case report	Berardelli,  I,  Vaia, et al	CNS Neurol Disord Drug Targets	Clinical data| Données cliniques Mental Health | santé mentale	Report the case of a 61-year-old HCW who likely infected her husband with SARS-CoV-2, leading to his death. We assessed the depressive and anxious symptoms that the patient experienced after the death of her husband, which were characterized by a deep sense of guilt, psychological pain, and thoughts of death.
PMC7543398; Electrocardiographic features of 431 consecutive, critically ill COVID-19 patients: an insight into the mechanisms of cardiac involvement	Bertini,  M,  Ferrari, et al	Europace	Clinical data| Données cliniques	Describe the electrocardiographic (ECG) features of critical COVID-19 patients. ECG was abnormal in 93% of the patients. Atrial fibrillation/flutter was detected in 22% of the patients. ECG signs suggesting acute right ventricular pressure overload (RVPO) were detected in 30% of the patients. In particular, 10% patients had the S1Q3T3 pattern, 9% had incomplete right bundle branch block (RBBB), and 11% had complete RBBB. ECG signs of acute RVPO were not statistically different between patients with (n = 104) or without (n=327) invasive mechanical ventilation during ECG recording (36% vs. 28%). Non-specific repolarization abnormalities and low QRS voltage in peripheral leads were present in 41% and 5%, respectively. In four patients showing ST-segment elevation, acute myocardial infarction was confirmed with coronary angiography. No ST-T abnormalities suggestive of acute myocarditis were detected. In the subgroup of 110 patients where high-sensitivity troponin I was available, ECG features were not statistically different when stratified for above or below the 5 times upper reference limit value.
Possible Case of Children Onset Systemic Lupus Erythematosus Triggered by Covid-19	Bettiol,  Clémence Odile,  Ntagerwa, et al	Research Square prepub	Clinical data| Données cliniques	This case report will present the case of an 11 years old child diagnosed with childhood-onset systemic lupus erythematosus (cSLE) during the coronavirus Covid-19 pandemic. Her initial symptoms were compatible with a Covid-19 infection but repeated PCR on naso-pharyngeal swabs were negative. Two serological assays were carried out but only one showed doubtful IgG results. Considering that viral infection could be responsible for autoimmune disease outbreaks and with increasing evidences of SARS Cov 2 actions on human inflammatory and immune systems; we discuss here a potential cSLE diagnosis triggered by Covid-19 infection.
SARS-Cov-2 ORF3a: Mutability and function	Bianchi,  M,  Borsetti, et al	Int J Biol Macromol	Coronavirology| Coronavirologie	Analyzed changes in SARS-CoV-2 Orf3a protein during the COVID-19 pandemic. A set of 70,752 high-quality SARS-CoV-2 genomes available in GISAID databank at the end of August 2020 were scanned. All ORF3a mutations in the virus genomes were grouped according to the collection date interval and over the entire data set. The top five most frequent variants were examined within each collection interval. Overall, seventeen variants have been isolated. Ten of the seventeen mutant sites occur within the transmembrane (TM) domain of ORF3a and are in contact with the central pore or side tunnels. The other variant sites are in different places of the Orf3a structure. Within the entire sample, the five most frequent mutations are V13L, Q57H, Q57H + A99V, G196V and G252V. The same analysis identified 28 sites identically conserved in all the genome isolates.
Efficacy of the delta neutrophil index in predicting 30-day mortality in COVID-19 patients requiring intensive care	Birben,  B,  Duvenci Birben, et al	Int J Clin Pract	Clinical data| Données cliniques	Evaluated the efficacy of the delta neutrophil index in predicting mortality in intensive care patients diagnosed with Coronavirus-19. Of the 388 patients receiving intensive care, 56.7% were male. The mean age was 70 years. The evaluation of mortality, 68% of the patients survived. The delta neutrophil index, neutrophil lymphocyte ratio, lactate, interleukin-6 and C-reactive protein values were statistically significantly higher and the lymphocyte value was significantly lower in the mortality group. In the receiver operating characteristic curve analysis, the area under the curve values of the delta neutrophil index, lymphocyte, neutrophil lymphocyte ratio, lactate, interleukin-6 and C-reactive protein levels in predicting mortality were .718, .416, .628, .585, .701, and .684, respectively.
Perceived barriers and preventive measures of COVID-19 among healthcare providers in debretabor, north central Ethiopia, 2020	Birihane,  BM,  Bayih, et al	Risk Management and Healthcare Policy	Healthcare Response | Réponse des soins de santé	Assessed perceived barriers and preventive measures of corona virus disease among healthcare providers in Debretabor Town, north central Ethiopia. A total of 183 healthcare providers participated in the survey, of which 67.76% were males, and 80.87% were in the age range of 25–35 years. About 45% of participants were nurses. In the current study, overall preventive practice was 68.3%. Despite recommendations by the World Health Organization, avoidance of outdoor, physical distancing, and avoiding meeting a person with a cough were not implemented by 32.24%, 24.18%, and 13.11% of healthcare providers, respectively. Insufficient training, lack of policy, less commitment to infection control, and limitations of resources were perceived as major barriers for practicing preventive measures during the pandemic.
Modeling dynamic patterns from COVID-19 data using randomized dynamic mode decomposition in predictive mode and ARIMA	Bistrian,  DA,  Dimitriu, et al		Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	The aim of this paper is to gain a deeper understanding of the new Corona virus (Covid-19) dynamics directly from the raw data reported by World Health Organization. We provide a high fidelity mathematical model, fast and computationally inexpensive for modeling the evolution of the pandemic worldwide and we develop an effcient tool for medium term prediction of pandemic dynamics, including infection spreading. We illustrate the excellent behavior of the non-intrusive reduced order model by performing a qualitative analysis. © 2020 Author(s).
Modelling the effect of self-immunity and the impacts of asymptomatic and symptomatic individuals on COVID-19 outbreak	Biswas,  MHA,  Islam, et al	CMES - Computer Modeling in Engineering and Sciences	Modelling/ prediction| Modélisation/prédiction Transmission	Describe a nine mutually exclusive compartmental model on transmission dynamics of this pandemic disease (COVID-19), with special focus on the transmissibility of symptomatic and asymptomatic infection from susceptible individuals. Herein, the compartmental model has been investigated with mathematical analysis and computer simulations in order to understand the dynamics of COVID-19 transmission. Initially, mathematical analysis of the model has been carried out in broadly by illustrating some well-known methods including exactness, equilibrium and stability analysis in terms of basic reproduction number. We investigate the sensitivity of the model with respect to the variation of the parameters' values. Furthermore, computer simulations are performed to illustrate the results. Our analysis reveals that the death rate from coronavirus disease increases as the infection rate increases, whereas infection rate extensively decreases with the increase of quarantined individuals. The quarantined individuals also lead to increase the concentration of recovered individuals. However, the infection rate of COVID-19 increases more surprisingly as the rate of asymptomatic individuals increases than that of the symptomatic individuals.
PMC7598376; Community Coronavirus Disease 2019 Activity Level and Nursing Home Staff Testing for Active Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Indiana	Blackburn,  J,  Weaver, et al	J Am Med Dir Assoc	Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé	Assessed whether using COVID-19 community activity level can accurately inform strategies for routine testing of facility staff for active SARS-CoV-2 infection. The detection of any infected staff within a facility using county cases per 10,000 population or county positivity rate resulted in an area under the curve of 0.648 and 0.649, respectively. Of staff tested, 28.0% were certified nursing assistants, yet accounted for 36.9% of all staff testing positive. Similarly, licensed practical nurses were 1.4% of staff, but 4.7% of positive cases.
Anti-heart antibodies levels and their correlation with clinical symptoms and outcomes in patients with confirmed or suspected diagnosis COVID-19	Blagova,  O,  Varionchik, et al	Eur J Immunol	Epidemiology| Épidémiologie Clinical data| Données cliniques	Evaluated the blood level of anti-heart antibodies (AHA) and its correlation with clinical outcomes in patients with severe and moderate COVID-19. The study included 34 patients (23 males; mean age 60.2±16.6 years) with COVID-19 pneumonia. Median hospital length of stay was 14 days. AHA levels were increased in 73.5% patients. Significant correlation of AHA levels with cardiovascular manifestations (r = 0.459) was found. AbC levels correlated with pneumonia severity (r = 0.472), respiratory failure (r = 0.387), need for invasive ventilation (r = 0.469), chest pain (r = 0.374), low QRS voltage (r = 0.415) and levels of CRP (r = 0.360) and LDH (r = 0.360). ASMA levels were found to correlate with atrial fibrillation (r = 0.414). ANA and AbC levels correlated with pericardial effusion (r = 0.721 and r = 0.745 respectively). The lethality rate was 8.8%. AbC and ASMA levels correlated significantly with lethality (r = 0.363, and r = 0.426 respectively) and were prognostically important.
Covid-well: Evaluation of the implementation of supported wellbeing centres for hospital employees during the COVID-19 pandemic	Blake,  H,  Yildirim, et al	International Journal of Environmental Research and Public Health	Mental Health | santé mentale Healthcare Response | Réponse des soins de santé	Determined facility usage of Supported Wellbeing Centres and gather insight into employee wellbeing and the views of employees towards this provision. Over 17 weeks, 14,934 facility visits were recorded across two sites (peak attendance in single week n = 2605). Facilities were highly valued, but the service model was resource intensive with 134 wellbeing buddies supporting the centres in pairs. 819 hospital employees completed an online survey (88% female; 37.7% working in COVID-19 high risk areas; 52.4% frontline workers; 55.2% had accessed a wellbeing centre). There was moderate-to-high job stress (62.9%), low wellbeing (26.1%), presenteeism (68%), and intentions to leave (31.6%). Wellbeing was higher in those that accessed a wellbeing centre. Work engagement and job satisfaction were high.
Thromboelastography clot strength profiles and effect of systemic anticoagulation in COVID-19 acute respiratory distress syndrome: A prospective, observational study	Bocci,  MG,  Maviglia, et al	European review for medical and pharmacological sciences	Clinical data| Données cliniques	We conducted a single-center observational study with the aim of analyzing the coagulation patterns of intensive care unit (ICU) COVID-19 patients with both standard laboratory and viscoelastic tests. SARS-CoV-2 patients with acute respiratory distress syndrome show elevated fibrinogen activity, high D-dimer levels and maximum amplitude of clot strength. At seven days, thromboelastographic abnormalities persist despite full-dose anticoagulation.
Characteristic spatial scales of SARS-CoV-2 pandemics: lessons from mass rapid antigen testing in Slovakia	Boďová,  Katarína,  Kollár, et al	medRxiv	Epidemiology| Épidémiologie	We perform statistical analysis and study epidemic geographical patterns of mass antigen testing data in Slovakia conducted in October and November 2020. We observe exponentially distributed test positivity and exponential trends in its geographical distribution, and its approximately 10 km spatial characteristic correlation length.  A small correlation between positivity in two consecutive testing rounds appeared on the municipalities level but it significantly increased on the counties level.
Socio-demographic predictors of adherence to 2019 coronavirus prescribed recommendations and lockdown psychological impacts: Perspectives of nigerian social media users	Bolarinwa,  OA,  Olagunju, et al	Journal of Public Health Research	Public Health response| Interventions de santé publique	This study was aimed at examining the socio-demographic predictors of adherence to prescribed recommendations and the psychological impacts of COVID-19 pandemic lockdown among Nigerian social media users. We concluded that majority of Nigerian social media users were complying to the prescribed recommendations and that younger age group, female respondents and respondents who are more educated had higher proportion of psychological impacts of lockdown, while the medical/scientific background is the only socio-demographic predictor of psychological impacts of COVID-19 lockdown.
Regionalizing Partitioning Africa's Coronavirus (COVID-19) Fatalities Using Environmental Factors and Underlying Health Conditions for Social-economic Impacts	Boluwade,  A		Epidemiology| Épidémiologie	The primary aim of this paper is to combine and cluster these two air qualities indicators, preexisting heart conditions due to morbidity and mortality from cardiovascular disease (MMDC), the probability from dying from four main (cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes) non-communicable diseases (NCDs) using a self-organizing map (SOM) and the hierarchical clustering method (HCM). The results show that the countries with the highest COVID-19 deaths and cases as of 12 July 2020 are Egypt (3769 and 81,158) and South Africa (3971 and 264,184). Notably, these two countries also have high rates of pre-existing health conditions (MMDC, NCDs), poor air quality indicators (NO2 and PM2.5) and pollution levels.
Perceived stress and social support in a large population of people with Multiple Sclerosis recruited online through COVID 19 pandemic	Bonavita,  S,  Sparaco, et al	Eur J Neurol	Mental Health | santé mentale	The aim was to investigate perceived stress, depression, perceived social support, habits, and behavior changes in people with MS (pwMS) through COVID19 in comparison to control people. A secondary group of people with migraine has been investigated. A higher proportion of pwMS were depressed (43.1% vs 23.1%; p<0.001), had high level of perceived stress (58% vs 39.8%; p<0.001) and felt significantly less social support (median 33 vs 35; Q1‐Q3 28‐36 vs 32‐37; p<0.001).) compared to the control group. A higher percentage of people with migraine were depressed (50% vs 43%, p=0.04) compared to pwMS.
Effect of age, comorbidity and remission status on outcome of COVID-19 in patients with hematological malignancies	Borah,  P,  Mirgh, et al	Blood Cells, Molecules, and Diseases	Epidemiology| Épidémiologie Clinical data| Données cliniques	Primary objective of study was to analyse the 14-day and 28-day mortality of COVID-19 in patients with hematological malignancies. Secondary objectives were to correlate age, comorbidities and remission status with outcome. Elderly patients with hematological malignancy and severe covid-19 have worst outcomes specially when disease is not in remission.
A discrete epidemic model and a zigzag strategy for curbing the Covid-19 outbreak and for lifting the lockdown	Boulmezaoud,  TZ	Mathematical Modelling of Natural Phenomena	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	This study looks at the dynamics of a Covid-19 type epidemic with a dual purpose. The first objective is to propose a reliable temporal mathematical model, based on real data and integrating the course of illness. The second objective is to study several original scenarios for the epidemic’s evolution, especially after the period of strict lockdown.
Results of multicenter monitoring of hemostasis parameters in patients with covid-19	Bovt,  EA,  Brazhnik, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Clinical data| Données cliniques	A prospective non-randomized pilot multicenter study of the informative-ness and clinical significance of hemostasis laboratory tests in 1210 patients with COVID-19 in disease course, including favorable and unfavorable outcomes, was performed. Comparison of COVID-19 laboratory parameters and clinical picture showed that 75% of patients have pronounced activation of the plasma coagulation system upon admission to the hospital.
Short-term forecasting of COVID-19 in Germany and Poland during the second wave – a preregistered study	Bracher,  J,  Wolffram, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction	We report insights from ten weeks of collaborative COVID-19 forecasting for Germany and Poland (12 October – 19 December 2020). Thirteen independent teams provided probabilistic real-time forecasts of COVID-19 cases and deaths. Heterogeneity between forecasts was considerable both in terms of point predictions and forecast spread.
Introduction to and spread of COVID-19-like illness in care homes in Norfolk, UK	Brainard,  J,  Rushton, et al	J Public Health (Oxf)	Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé	We undertook secondary analysis of 248 care homes in Norfolk, UK. Counts of non-care workers had strongest relationships (P < 0.05) to introduction of suspected SARS-CoV-2 to the homes. Higher staff levels and more severe PPE shortages were linked to higher case counts (P < 0.05) during the monitoring period.
Estimating (quality-adjusted) life-year losses associated with deaths: With application to COVID-19	Briggs,  AH,  Goldstein, et al	Health Econ	Epidemiology| Épidémiologie	In this paper we employ standard life table methods to illustrate how the potential quality‐adjusted life‐year (QALY) losses associated with COVID‐19 fatalities could be estimated, while adjusting for comorbidities in terms of impact on both mortality and quality of life. In particular, we compare five different countries and show that differences in the average QALY losses for each COVID‐19 fatality is driven mainly by differing age distributions for those dying of the disease.
The Safe Resumption of Elective Plastic Surgery in Accredited Ambulatory Surgery Facilities During the COVID-19 Pandemic	Brown,  M,  Eardley, et al	Aesthet Surg J	Healthcare Response | Réponse des soins de santé	The objective is to examine outcomes following elective aesthetic surgery and the impact on the Canadian health care system with the resumption of these services during the COVID-19 worldwide pandemic. With appropriate screening and safety precautions, elective aesthetic plastic surgery can be performed in a manner that is safe for patients and health care providers and with a very low risk for accelerating virus transmission within the community.
Prevalence and Neighborhood Geomapping of COVID-19 in an Underserved Chicago Pregnant Population	Buhimschi,  CS,  Elam, et al	AJP Reports	Epidemiology| Épidémiologie	We studied the prevalence and neighborhood distribution of patients who tested positive for COVID-19 after implementation of universal screening at an academic hospital providing obstetrical services to an underserved Chicago population. The prevalence of an outpatient RT-PCR positive result was 8.9% (9/101). All but one of the 29 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive patients were either Hispanic or Black, and the majority resided in disadvantaged neighborhoods.
Race and Ethnic Group Disparities in Emotional Distress Among Older Adults During the COVID-19 Pandemic	Bui,  CN,  Peng, et al	Gerontologist	Mental Health | santé mentale	Framed within Conservation of Resources theory, this study addressed race-ethnic differences in the relationships between emotional distress and current and expected Coronavirus Disease - 2019 (COVID-19) pandemic stressors.  In relation to current stressors, older Black persons responded with less emotional distress and older Latino persons responded with more emotional distress than older White persons.
Estimation of the incubation period of COVID-19 in Vietnam	Bui,  LV,  Nguyen, et al	PLoS One	Clinical data| Données cliniques	The objective was to estimate the incubation period of Vietnamese confirmed COVID-19 cases (n=19). This analysis provides evidence for an average incubation period for COVID-19 of approximately 6.4 days. Our findings support existing guidelines for 14 days of quarantine of persons potentially exposed to SARS-CoV-2.
Quantitative Detection of SARS-CoV-2 RNA in nasopharyngeal samples from infected patients with mild disease	Bustos,  P,  Tambley, et al	J Med Virol	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In this paper, the association of viral load and severity of the disease is evaluated. Fever, either as an exclusive symptom or combined with others, was associated with high viral loads. During the first week after onset of symptoms in mild patients up to 60 years‐old was detected the peak of viral load. Children under 10 years‐old have a high viral load in the first two days post‐infection with a sharp decline thereafter. Patients over 60 years‐old have high viral load up to the second week after the onset of symptoms, indicating the longer presence of the virus in them.
Bilateral facial nerve palsy associated with COVID-19 and Epstein–Barr virus co-infection	Cabrera Muras,  A,  Carmona-Abellán, et al	European Journal of Neurology	Clinical data| Données cliniques	We here report a patient who presented with severe bilateral facial palsy and evidence of SARS‐CoV‐2 infection preceded by upper respiratory symptoms. He also had serological evidence of coinfection with Epstein‐Barr virus, which could have also played a role in his neurological manifestations. The patient was treated with prednisone 60 mg/24h with a tapering schedule and had a favorable outcome, with an almost complete recovery in 3 weeks.
Clinical diagnosis of COVID-19: a prompt, feasible, and sensitive diagnostic tool for COVID-19 based on a 1,757-patient cohort (The AndroCoV Clinical Scoring for COVID-19 diagnosis)	Cadegiani,  FlavioA,  McCoy, et al	Research Square prepub	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Our objective was to propose a clinical scoring for the diagnosis of COVID-19 (The AndroCoV Clinical Scoring for COVID-19 Diagnosis) that has been validated in a large population sample, aiming to encourage the management of patients with high pre-clinical likelihood of presenting COVID-19, at least during the pandemics, independent of a rtPCR-SARS-COV-2 test. Among the multiple combinations, requiring two or more symptoms with or without anosmia or ageusia for subjects without known contact and one or more symptoms with or without anosmia or ageusia with known positive contacts presented the highest accuracy (80.4%), and higher pretest probability and accuracy than virtually all rtPCR-SARS-CoV-2 commercially available kit tests.
Impact of personal protective equipment on prehospital endotracheal intubation performance in simulated manikin	Çağlar,  A,  Kaçer, et al	Australas Emerg Care	Healthcare Response | Réponse des soins de santé	This study aimed to primarily examine the effect of PPE use on intubation time and success rate among prehospital healthcare professionals; additionally, we compared intubation times among prehospital health care professionals using PPE with direct laryngoscopy and video laryngoscopy assistance. PPE use is associated with increased intubation time and decreased success rate. Video laryngoscopy assistance in cases where PPE use is required facilitates faster endotracheal intubation than does direct laryngoscopy assistance.
Correspondence on â Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: Results of the CHIC study'	Calvo-Aranda,  E,  Canãmares-Orbis, et al	Annals of the Rheumatic Diseases	Clinical data| Données cliniques Therapeutics| Thérapeutique	We decided to explore a therapeutic combination of a 3-day course of low-dose subcutaneous anakinra (LDSA; 100 mg/day) and GC in those patients with moderate-severe COVID-19 refractory to standard-of-care treatment. Our results show that anakinra may be a valid alternative option in the management of patients with moderate–severe COVID-19, constituting an available treatment with a lower cost than other immunosuppressants such as tocilizumab and a good safety profile.
In silico discovery of antigenic proteins and epitopes of SARS-CoV-2 for the development of a vaccine or a diagnostic approach for COVID-19	Can,  H,  Köseoğlu, et al	Sci Rep	Coronavirology| Coronavirologie	Among the 27 proteins encoded in the SARS-CoV-2 genome, the present study aimed to discover likely antigenic proteins and epitopes to be used for the development of a vaccine or serodiagnostic assay using an in silico approach. Spike protein was selected as the best vaccine candidate because of having a signal peptide, negative GRAVY value, one transmembrane helix, moderate aliphatic index, a big molecular weight, a long-estimated half-life, beta wrap motifs as well as having stable, soluble and non-allergic features. Nucleocapsid protein and a highly antigenic GGDGKMKD epitope were identified as ideal antigens to be used in the development of serodiagnostic assays. Moreover, considering MHC-I alleles, highly antigenic KLNDLCFTNV and ITLCFTLKRK epitopes can be used to develop an epitope-based peptide vaccine.
Clinical and imaging features of novel coronavirus pneumonia in the elderly compared with young and middle-aged individuals	Cao,  J,  Zhou, et al	Iranian Journal of Radiology	Clinical data| Données cliniques	We aimed to analyze the computed tomography (CT) imaging characteristics and clinical features of elderly patients with novel COVID-19 and compare them with young COVID-19 patients, in order to provide imaging basis for clinical diagnosis. Elderly and young patients with corona virus disease had some common CT and clinical features, but elderly patients may have relatively severe CT findings, and these differences may be related to the severity and prognosis of COVID-19 pneumonia.
Lack of Association of Initial Viral Load in SARS-CoV-2 Patients with In-Hospital Mortality	Carrasquer,  A,  Peiró Ó, et al	Am J Trop Med Hyg	Epidemiology| Épidémiologie Clinical data| Données cliniques	We carried out a retrospective observational study of 169 patients, 96 (58.9%) of whom had a high viral load and the remaining had a low viral load. High viral loads were associated with in-hospital mortality in the binary logistic regression analysis. However, in an analysis adjusted for age, gender, Charlson Index (CI), and cardiac troponin I (cTnI), viral load was no longer a predictor of mortality. In conclusion, an elevated nasopharyngeal viral load was not a determinant of in-hospital mortality in patients with COVID-19, as much as age, comorbidity, and myocardial damage determined by elevated cTnI are.
Clinical epidemiological characterization of pregnant women suspected and positive for COVID-19	Carreras,  SU,  Fernández, et al	Revista Cubana de Medicina Militar	Epidemiology| Épidémiologie Clinical data| Données cliniques	A descriptive, observational, cross-sectional study was carried out in 56 patients to determine the clinical and epidemiological differences of the pregnant women suspect of and positive for COVID-19.  There were clinical and epidemiological differences between the suspect and positive patients for COVID-19.
COVID-19 Chest Computed Tomography to Stratify Severity and Disease Extension by Artificial Neural Network Computer-Aided Diagnosis	Carvalho,  ARS,  Guimarães, et al	Frontiers in Medicine	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	This work aims to develop a computer-aided diagnosis (CAD) to quantify the extent of pulmonary involvement (PI) in COVID-19 as well as the radiological patterns referred to as lung opacities in chest computer tomography (CT). The proposed CAD aided in detecting and quantifying the extent of pulmonary involvement, helping to phenotype patients with COVID-19 pneumonia.
Spatial Allocation of Scarce Vaccine and Antivirals for COVID-19*†‡</sup&gt	Castonguay,  FrançoisM,  Blackwood, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de sant&amp;eacute; publique	Utilizing economic–epidemiological modeling, we benchmark the performance of ad hoc allocation rules of scarce vaccines and drugs by comparing them to the rules for a vaccine and for a drug treatment that minimize the economic damages and expenditures over time, including a penalty cost representing the social costs of deviating from an ad hoc allocation.  For vaccines, the benefits from deviating are especially high when immunity is permanent, when there is compliance to travel restrictions, and when the supply of vaccine is low. Interestingly, a lack of compliance to travel restrictions pushes the optimal allocations of vaccine towards the ad hoc and improves the relative robustness of the ad hoc rules, as the mixing of the populations reduces the spatial heterogeneity in disease burden.
MHC-II constrains the natural neutralizing antibody response to the SARS-CoV-2 spike RBM in humans	Castro,  Andrea,  Ozturk, et al	bioRxiv	Immunology | Immunologie	Here we revisit T-B cooperation as a prerequisite for effective and durable neutralizing antibody responses centered on a mutationally constrained receptor binding motif (RBM) B cell epitope. Examining common MHC-II alleles, we found that peptides surrounding this key B cell epitope are predicted to bind poorly, suggesting a lack MHC-II support in T-B cooperation, impacting generation of high-potency neutralizing antibodies in the general population. Additionally, we found that multiple microbial peptides had potential for RBM cross-reactivity, supporting previous exposures as a possible source of T cell memory.
Support and follow-up needs of patients discharged from Intensive Care after severe COVID-19: a mixed-methods study of the views of UK general practitioners and intensive care staff during the pandemic’s first wave	Castro-Avila,  Ana,  Jefferson, et al	medRxiv	Healthcare Response | Réponse des soins de santé	In this sequential mixed-methods UK study, we explored usual follow-up practice after ICU discharge and changes in follow-up during the pandemic through a survey of ICU staff, and GP awareness of follow-up and support needs of patients discharged from ICU through a survey of GPs. The pandemic has highlighted long-standing issues of continuity of care and complex funding streams for post-ICU follow-up care. The large cohort of ICU patients admitted due to COVID-19 highlights the need for improved follow-up services and communication between specialists and GPs, not only for COVID-19 patients, but for all those discharged from ICU.
Analytical and clinical evaluation of four commercial SARS-CoV-2 serological immunoassaysin hospitalized patients and ambulatory individuals	Catry,  E,  Jacqmin, et al	J Virol Methods	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology | Immunologie	This study aimed to compare four anti-SARS-CoV-2 immunoassays in populations presenting different clinical severity levels. The antibody levels and the evaluated sensitivities, representing the true positive rate, increased over time and were related to the COVID-19 severity. Automated Total Ab immunoassay showed better sensitivities and specificity for immunological surveillance and vaccine evaluation.
Mental health, personality and lifetime psychedelic use during the COVID-19 pandemic	Cavanna,  Federico,  Pallavicini, et al	medRxiv	Mental Health | santé mentale	Building on previous work on the potential long-term benefits of psychedelics, we hypothesized that lifetime use of these drugs could be linked to better mental health indicators in the context of the ongoing pandemic. We did not find evidence of an association between lifetime use of psychedelics and poor mental health indicators. Conversely, experience with psychedelic drugs was linked to increased positive affect and to personality traits that favor resilience and stability in the light of the ongoing crisis.
Tele-medicine versus face-to-face consultation in Endocrine Outpatients Clinic during COVID-19 outbreak: a single-center experience during the lockdown period	Ceccato,  F,  Voltan, et al	J Endocrinol Invest	Healthcare Response | Réponse des soins de santé	We have developed and applied an emergency plan, tailored for Outpatients with endocrine diseases. 86% of patients contacted by endocrine-triage received a clinical response (F2F and tele-Endo visits). F2F visit was offered especially to young patients; tele-Endo was applied to 63% of geriatric patients (p < 0.001), visits’ outcome was similar between young and aged patients.
Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis	Cerdà,  P,  Ribas, et al	PLoS One	Epidemiology| Épidémiologie Clinical data| Données cliniques	The main objective was to assess clinical and laboratory differences in hospitalized COVID-19 patients according to occurrence of pulmonary embolism (PE). Among hospitalized COVID-19 patients, D-dimer levels are higher at weeks 2, 3 and 4 after COVID-19 symptom onset in patients who develop PE. This difference is more pronounced when the fold increase between weeks 1 and 2 is compared.
Correlation of the renal function changes to prognosis in critical patients with COVID-19	Chao-Chen,  W,  Yi-Sha, et al	Medical Journal of Chinese People's Liberation Army	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objective was to get the message of kidney injury and its causes in patients with COVID-19, and analyze the correlation of kidney injury to COVID-19 typing and prognosis, so provide a reference for the treatment and prognosis evaluation of COVID-19.  The elevated levels of blood urea nitrogen (BUN) at admission and one week after admission were the important clinical features and independent risk factors associated with the death of critical COVID-19 patients.
Clinical features associated with COVID-19 outcome in multiple myeloma: first results from the International Myeloma Society data set	Chari,  A,  Samur, et al	Blood	Epidemiology| Épidémiologie Clinical data| Données cliniques	This retrospective study describes the baseline characteristics and outcome data of COVID-19 infection in 650 patients with plasma cell disorders, collected by the International Myeloma Society to understand the initial challenges faced by myeloma patients during the COVID-19 pandemic. Multivariate analysis found that only age, high-risk MM, renal disease, and suboptimal MM control remained independent predictors of adverse outcome with COVID-19 infection.
Epidemiological analysis of 18 patients with COVID-19	Chen,  G,  Wu, et al	European review for medical and pharmacological sciences	Epidemiology| Épidémiologie Clinical data| Données cliniques	A descriptive epidemiological study of 18 patients with COVID-19 in People’s Hospital of Deyuan was carried out. The epidemiological characteristics were as follows: (1) the median incubation period was 8 days (with an interquartile range of 4-12 days); (2) the incubation period in one case was ≥18 days; (3) one infant patient was asymptomatic prior to their diagnosis; and (4) two asymptomatic patients had a positive nucleic acid test after their family members were diagnosed with COVID-19.
PMC7665678; The spread rate of SARS-CoV-2 is strongly associated with population density	Chen,  K,  Li, et al	J Travel Med	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	This study investigates the spread rates of SARS-CoV-2 in different regions with different population densities. This study has proved that the spread rate of SARS-CoV-2 is strongly associated with population density, and diversified control and prevention measures should be made for different regions according to population density.
Patterns of Deterioration in Moderate Patients With COVID-19 From Jan 2020 to Mar 2020: A Multi-Center, Retrospective Cohort Study in China	Chen,  SL,  Feng, et al	Frontiers in Medicine	Epidemiology| Épidémiologie Clinical data| Données cliniques	All moderate COVID-19 patients hospitalized in Guangdong Province from January 14 to March 16, 2020, were included in this multicenter retrospective cohort study and symptoms, demographic, therapeutic, and laboratory test result characteristics were evaluated with respect to deteriorated and non-deteriorated groups.  The deteriorated pattern of moderate COVID-19 patients is characterized as the 11th day from onset (IQR 9–14 days) being an important time point of disease deterioration with further exacerbation to critical condition in 3 days (IQR 2–6.5 days), Acute respiratory distress syndrome followed by acute kidney injury being the typical modes of sequential organ damage.
A Rapid and high-sensitive real-time reverse transcription-polymerase chain reaction assay used for the detection of severe acute respiratory syndrome coronavirus 2	Chen,  X,  Xu, et al	Nano Biomedicine and Engineering	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In this study, we improved the real-time RT-PCR method based on three target regions (ORF1ab, E, and N) of SARS-CoV-2. Results showed that real-time RT-PCR assays herein could complete detection within one hour after viral RNA preparation and had high sensitivity down to 5 copies of viral RNA.  In addition, six clinical specimens were detected to evaluate the availability of this method. Among them, four samples were 3-plex SARS-CoV-2 positive and two were negative by real-time RT-PCR. These results demonstrate that we develop a rapid and high-sensitive real-time RT-PCR method for SARS-CoV-2 detection, which will be a powerful tool for COVID-19 identification and for monitoring suspected patients.
Clinical Characteristics of 33 Asymptomatic COVID-19 Infections in Wuhan, China	Chen,  Y,  Chen, et al	Journal of infection in developing countries	Clinical data| Données cliniques	Clinical characteristics of 33 asymptomatic COVID-19 infections were analyzed in this study. The data showed most of asymptomatic patients had small body mass index, good prognosis and low infectivity. This study suggests that screening from high-risk populations to find and isolate asymptomatic patients is an important disease prevention and control strategy for COVID-19.
Epidemiological characteristics of COVID-19 in Wuchang district of Wuhan	Chen,  YL,  Wang, et al	Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi	Epidemiology| Épidémiologie	Objective of this study is to analyze epidemiological characteristics of COVID-19 and provide evidence for adjustment for COVID-19 prevention and control strategies. The data of COVID-19 cases in Wuchang district reported as of 19 March, 2020 were obtained from National Notifiable Disease Report System of Chinese Disease Prevention and Control Information System.  Study conclusions include  (1) The gender, ages and occupation of distribution were wide among COVID-19 cases in Wuchang district. (2) Males, aged >50 years, severe cases and critical cases of clinical classification were influencing factors of prognosis of COVID-19 confirmed cases. and (3) The standardized management of discharged cases, asymptomatic infected cases and close contact persons were main measures to reduce incidence rates of COVID-19 cases.
Preliminary analysis on COVID-19 case spectrum and spread intensity in different provinces in China except Hubei province	Cheng,  C,  Chen, et al	Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi	Epidemiology| Épidémiologie	To analyze the characteristics of COVID-19 case spectrum and spread intensity in different provinces in China except Hubei province using daily incidence data and case information of COVID-19 obtained from the official websites of provincial and municipal health commissions.  The study concluded that the intervention measures were effective in preventing the spread of COVID-19 and improved treatment effect in China despite the existence of  significant differences among different regions in severity, case-fatality rate and spread ratio.
Social Capital-Accrual, Escape-From-Self, and Time-Displacement Effects of Internet Use During the COVID-19 Stay-at-Home Period: Prospective, Quantitative Survey Study	Cheng,  C,  Lau, et al	J Med Internet Res	Mental Health | santé mentale	The objectives of this study were to assess the prevalence of probable depression during the COVID-19 stay-at-home period and to test three hypothesized risk reduction or risk elevation mechanisms, namely social capital-accrual, escape-from-self, and time-displacement effects. The study concluded that during the extended stay-at-home period in the early stages of the COVID-19 pandemic, the prevalence of probable depression during the 2-month study period was high among UK and US residents.  As well the study reported that individuals with distinct coping styles engaged in different types of online leisure activities and perceive varying levels of social support, which are associated with risks of probable depression.
Using Test Positivity and Reported Case Rates to Estimate State-Level COVID-19 Prevalence and Seroprevalence in the United States	Chiu,  WeihsuehA,  Ndeffo-Mbah, et al	medRxiv	Healthcare Response | Réponse des soins de santé	Accurate estimates of infection prevalence and seroprevalence are essential for evaluating and informing public health responses needed to address the ongoing spread of COVID-19 in the United States. As such a data-driven Bayesian single parameter semi-empirical model was developed and used to evaluate state-level prevalence and seroprevalence of COVID-19 using daily reported cases and test positivity ratios. The study concluded that use of this simple and easy-to-communicate model can improve the ability to make public health decisions that effectively respond to the ongoing pandemic.
Cardiac arrhythmias in hospitalized patients with COVID-19: A prospective observational study in the western United States	Cho,  JH,  Namazi, et al	PLoS One	Clinical data| Données cliniques	Arrhythmias has been frequently reported in COVID-19 patients, but the incidence and nature has not been well characterized as such the incidence and types of cardiac arrhythmias  among 143 patients admitted with COVID-19 were analyzed and compared between survivors and non-survivors. The study reported that sinus tachycardia, the most common arrhythmia (detected in 39.9% 57/143] of patients), occurred more frequently in non-survivors (58.3% vs. 33.6% in survivors, p = 0.009). As well it was reported that premature ventricular complexes occurred in 28.7% (41/143), and non-sustained ventricular tachycardia in 15.4% (22/143) of patients, with no difference between survivors and non-survivors. Lastly study concluded that contrary to reports from other regions, overall mortality was higher and ventricular arrhythmias were infrequent in this hospitalized and monitored COVID-19 population.
Association between oxygen saturation/fraction of inhaled oxygen and mortality in patients with COVID-19 associated pneumonia requiring oxygen therapy	Choi,  KJ,  Hong, et al	Tuberc Respir Dis (Seoul)	Clinical data| Données cliniques	This retrospective cohort study was conducted to determine whether oxygen saturation (SpO2) and SpO2/fraction of inhaled oxygen (FiO2) (SF ratio) predicts acute respiratory distress syndromes (ARDS) and mortality in COVID-19 pneumonia patients. The study concluded that the SF ratio on admission and the SF ratio at exacerbation can predict occurrence of ARDS. The SF ratio at exacerbation and National Early Warning Score (NEWS) has a significant effect on mortality.
Prevention of COVID-19 in Internally Displaced Persons Camps in War-Torn North Kivu, Democratic Republic of the Congo: A Mixed-Methods Study	Claude,  KM,  Serge, et al	Glob Health Sci Pract	Public Health response| Interventions de santé publique	We examined knowledge, attitudes, and practices with respect to COVID-19 prevention among  internally displaced persons (IDP) in war-torn Eastern Democratic Republic of the Congo (DRC). The study reported that IDPs had a high level of awareness (99%) and fear (98%) of COVID-19, but lower specific knowledge (15% sufficient knowledge versus 30% among the comparison group, P<.0001). As well, it was noted that IDPs faced major barriers to implementing COVID-19 prevention measures such as physical distancing and hand hygiene and were more vulnerable to getting infected by COVID-19 due to frequent movements in and out of refugee camp.
Patient experiences of virtual consultation during COVID 19: A musculoskeletal service evaluation	Cliffe,  S,  Stevenson, et al	Musculoskeletal Care	Healthcare Response | Réponse des soins de santé	Using a service evaluation methodology, study aimed to capture the views and experiences of patients referred into musculoskeletal services across Midlands Partnership NHS Foundation Trust (MPFT) who participated in a virtual consultation as opposed to face to face consultations during the beginning of the COVD 19 pandemic. The study evaluation highlighted positive patient experiences of using virtual consultations during the COVID pandemic. Furthermore it was reported that while two‐thirds of patients would still prefer a face to face appointment after COVID, a third would consider alternative types of appointments.
Outcomes of COVID-19 Among Hospitalized Patients With Non-dialysis CKD	Coca,  A,  Burballa, et al	Frontiers in Medicine	Epidemiology| Épidémiologie Clinical data| Données cliniques	Chronic kidney disease (CKD) has been associated with increased mortality in previous epidemics, but there is a paucity of data regarding actual risks for non-dialysis CKD patients with COVID-19.  To fill this gap, a multi-center, observational cohort study including 136 non-dialysis CKD patients and 136 age- and sex-matched controls that required hospitalization due to COVID-19 was undertaken. The study reported that CKD patients who required hospitalization due to COVID-19 were exposed to a higher risk of death and acute kidney injury.
Treatment of a case with COVID-19 administering intravenous immunoglobulin	Çolak,  M,  Kalemci, et al	J Glob Antimicrob Resist	Clinical data| Données cliniques	This  is a case study report of  a 49-year-old man with a history of irregular type 2 diabetes COVID-19  patient who was treated with (IVIG). The report provides information on whether the use of intravenous immunoglobulin (IVIG ) as a therapeutic agent in SARS-CoV-2 infection in the modulation of inflammation is effective. The study concluded that IVIG administration could be beneficial in the treatment of patients with severe COVID-19.
Head and neck cancer surgery during the COVID-19 pandemic: An international, multicenter, observational cohort study	Collaborative,  OVIDS C	Cancer	Healthcare Response | Réponse des soins de santé	The aims of this study were to provide data on the safety of head and neck cancer surgery currently being undertaken during the coronavirus disease 2019 (COVID-19) pandemic. This international, observational cohort study comprised 1137 consecutive patients with head and neck cancer undergoing primary surgery with curative intent in 26 countries.  The study concluded that head and neck surgery is safe for patients during the coronavirus disease 2019 pandemic even when it is lengthy and complex.
Orthodontic emergencies and perspectives during and after the COVID-19 pandemic: The italian experience	Colonna,  A,  Siciliani, et al	Pesquisa Brasileira em Odontopediatria e Clinica Integrada	Healthcare Response | Réponse des soins de santé	To investigate the types of dental emergencies that occurred during the lockdown period in Italy (12th March—4th May) and to investigate future therapeutic preferences related to the use of different types of appliances. The study reported that during the lockdown, there were relatively few orthodontic emergencies, many of which were handled by telephone consultation.  It was also highlighted that a far lower percentage of emergencies were generated by removable (e.g., clear aligners) as opposed to fixed appliances (e.g., multibracket equipment), likely influencing the decision of the majority of clinicians to opt for removable appliances in the wake of the COVID-19 pandemic.
Might proton pump or sodium-hydrogen exchanger inhibitors be of value to ameliorate SARs-CoV-2 pathophysiology?	Conrad,  KP	Physiol Rep	Therapeutics| Thérapeutique	This study assessed whether proton pump (PPIs) and sodium‐hydrogen exchanger inhibitors (NHEIs) can be used as therapeutics for COVID-19, because of their potential to inhibit the release of extracellular vesicles (EVs; exosomes and/or microvesicles) that could promote disease progression, and to directly disrupt SARs‐CoV‐2 pathogenesis. The study concluded that more evaluation of PPIs/NHEIs is needed in cell and animal models at various phases of SARs‐CoV‐2 infection to ascertain their potential efficacy.
COVID-19-associated PRES-like encephalopathy with perivascular gadolinium enhancement	Conte,  G,  Avignone, et al	American Journal of Neuroradiology	Clinical data| Données cliniques	This case report describes the case of a 63-year-old woman who developed a coronavirus disease 2019-associated acute encephalopathy with perivascular gadolinium enhancement.
Influence of HLA class II polymorphism on predicted cellular immunity against SARS-CoV-2 at the population and individual level	Copley,  HannahC,  Gragert, et al	bioRxiv	Immunology | Immunologie	We capitalised on extensive high resolution Human Leukocyte Antigen (HLA) data deposited in the National Marrow Donor Program registry to obtain detailed information on human HLA haplotype frequencies of twenty five human populations and used a bioinformatics approach to investigate the role of HLA polymorphism on SARS-CoV-2 immunogenicity at the population and at the individual level.  Our findings provide important insight on the potential role of HLA polymorphism on development of protective immunity after SARS-CoV-2 infection and after vaccination and a firm basis for further experimental studies in this field.
Incidence and severeness of COVID-19 hospitalisation in patients with inflammatory rheumatic disease: a nationwide cohort study from Denmark	Cordtz,  R,  Lindhardsen, et al	Rheumatology (Oxford)	Epidemiology| Épidémiologie	This is a nationwide cohort study from Denmark between 1 March to 12 August 2020.. It was undertaken to estimate the incidence of COVID-19 hospitalisation in patients with inflammatory rheumatic disease (IRD); in patients with rheumatoid arthritis (RA) treated with specific DMARDs; and the incidence of severe COVID-19 infection among hospitalised patients with RA. Study highlights that patients with IRD were more likely to be admitted with COVID-19 than the general population, and COVID-19 admitted patients with RA could be at higher risk of a severe outcome. Treatment with specific DMARDs did not affect the risk of hospitalisation.
Home garden use during COVID-19: Associations with physical and mental wellbeing in older adults	Corley,  J,  Okely, et al	Journal of Environmental Psychology	Mental Health | santé mentale	This study examined whether home garden usage is associated with self-reported mental and physical well-being in older adults, during COVID-19 lockdown in Scotland. This study analysed data from 171 individuals (mean age 84 ± 0.5 years) from the Lothian Birth Cohort 1936 study who completed an online survey approximately two months after lockdown commenced (May/June, 2020), and reported having access to a home garden. Study results provide support for positive health benefits of spending time in a garden—though associations may be bidirectional—and suggest that domestic gardens could be a potential health resource during the COVID-19 pandemic.
Decontamination and reuse of surgical masks and respirators during COVID-19 pandemic	Côrtes,  MF,  Espinoza, et al	Int J Infect Dis	Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)	We evaluated surgical masks and respirators reuse by analyzing their performance and safety before and after decontamination methods: oven, thermal drying, autoclave, and hydrogen peroxide plasma vapor. Study concluded that dry heat is a safe decontamination method of surgical masks and respirators for at least five cycles and is feasible in the hospital.
Adverse drug reactions in SARS-CoV-2 hospitalised patients: a case-series with a focus on drug-drug interactions	Crescioli,  G,  Brilli, et al	Intern Emerg Med	Clinical data| Données cliniques	The aim of the present case-series study is to describe clinical and pharmacological characteristics of SARS-CoV-2 hospitalised patients, focusing on adverse drug reactions (ADRs), particularly those related to drug-drug interaction (DDI) at the Careggi University Hospital, Florence (Italy), between January 1st and 31st May 2020. The case-by-case evaluation revealed the presence of one or more DDIs, especially those related to pharmacokinetic interactions. The study highlighted that despite the small number of patients, the evidence underline the clinical burden of DDIs in SARS-CoV-2 hospitalised patients and the risk of unexpected and uncommon psychiatric ADRs.
Forecasting COVID-19 Chile's second outbreak by a generalized SIR model with constant time delays and a fitted positivity rate	Cumsille,  Patricio,  Rojas-Díaz, et al	ArXiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	This study aims to develop a clear, efficient, and reproducible methodology for parameter optimization, whose implementation is illustrated using data from three representative regions from Chile and a suitable generalized SIR model together with a fitted positivity rate. Our results reproduce the general trend of the infected's curve, distinguishing the reported and real cases. Finally, our methodology is robust, and it allows us to forecast a second outbreak of COVID-19 and the infection fatality rate of COVID-19 qualitatively according to the reported dead cases.
Testing mobile air purifiers in a school classroom: Reducing the airborne transmission risk for SARS-CoV-2	Curtius,  J,  Granzin, et al	medRxiv	Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)	We tested the efficiency and practicability of operating four air purifiers equipped with HEPA filters in a high school classroom while regular classes were taking place. Aerosol number concentration for particles > 3 nm at two locations in the room, the aerosol size distribution in the range from 10 nm to 10 µm, PM10 and CO2 concentration were compared to a neighboring classroom without purifiers.  The study demonstrated that air purifiers potentially represent a well-suited measure to reduce the risks of airborne transmission of SARS-CoV-2 substantially. Also, the study estimated that the risk of getting infected after coming into contact for two hours with a highly infective person reduced by a factor of six when using air purifiers with a total air exchange rate of 5.7 h-1.
Implementation of photographic triage in a paediatric dental, orthodontic and maxillofacial department during COVID-19	Davies,  A,  Howells, et al	Int J Paediatr Dent	Healthcare Response | Réponse des soins de santé	AIM: To share our experience of photographic triage during the first three months of COVID-19 lockdown, lessons learned and recommendations. RESULTS: 220 photographic referrals were received, swelling (30%) and dental trauma (27%) were the commonest presenting complaints. 57% of referrals were not seen, 23% were seen semi-urgently and 20% booked for outpatient review. Of those seen, 7 children were seen elsewhere and 44 were seen face-to-face at AHCH, with 8 being admitted.
Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England	Davies,  NicholasG,  Barnard, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Transmission	This study was undertaken to detect a novel SARS-CoV-2 variant, VOC 202012/01 that emerged in southeast England in November 2020 and appears to be rapidly spreading towards fixation.  A two-strain mathematical model of SARS-CoV-2 transmission was fitted to observed COVID-19 hospital admissions, hospital and ICU bed occupancy, and deaths; SARS-CoV-2 PCR prevalence and seroprevalence; and the relative frequency of VOC 202012/01 in the three most heavily affected NHS England regions (South East, East of England, and London). The study was unable to find clear evidence that VOC 202012/01 results in greater or lesser severity of disease than preexisting variants. Nevertheless,  the study observed that the increase in transmissibility is likely to lead to a large increase in incidence, with COVID-19 hospitalisations and deaths projected to reach higher levels in 2021 than were observed in 2020, even if regional tiered restrictions implemented before 19 December are maintained.
Characterizing Long COVID in an International Cohort: 7 Months of Symptoms and Their Impact	Davis,  HannahE,  Assaf, et al	medRxiv	Long-Term Sequelae | séquelles à long terme	This international web-based survey of 56 countries  was conducted to characterize the symptom profile and time course in patients with Long COVID, along with the impact on daily life, work, and return to baseline health. Study reported that patients with Long COVID report prolonged multi-system involvement and significant disability.  As well, most had not returned to previous levels of work by 6 months and many patients had not recovered by 7 months, and continue to experience significant symptom burden.
von Willebrand factor/ADAMTS13 axis and venous thromboembolism in moderate-to-severe COVID-19 patients	Delrue,  M,  Siguret, et al	Br J Haematol	Clinical data| Données cliniques	We conducted a single‐centre, prospective study including all consecutive COVID‐19 adult patients admitted from 17 March 2020 to 11 April 2020 to our intensive care unit (referred as ‘critically ill patients’) and medicine ward (referred as ‘non‐critically ill patients’). This study was part of the ICU‐COVID and French‐COVID cohort registries approved by our institutional ethics committee. The study demonstrated that ADAMTS13 activity and VWF:Ag levels were significantly associated with VTE onset. Moreover, ADAMTS13 activity was significantly associated with survival.
Treatment Management of COVID-19 Positive Patients with Renal Colic Secondary to Distal Ureteral Stone	Demirdogen,  SO,  Cinislioglu, et al	Int J Clin Pract	Therapeutics| Thérapeutique	We aimed to contribute to the literature by sharing and evaluating the clinical characteristics and our treatment and follow-up approaches in patients in the COVID-19 positive treatment process who had presented to our hospital's emergency department with a distal ureteral stone and to examine the effects of the pandemic and disease in this group of patients. Study highlighted that in most COVID-19 infected patients with renal colic and a distal ureteral stone, results can be obtained using MET. As well, patients with a distal ureteral stone and persistent renal colic can be safely and effectively treated by endoscopic ureteral stone treatment after taking necessary precautions.
A New State-Space Epidemiological Model for Cost-Effectiveness Analysis of Non-Medical Interventions- A Study on COVID-19 in California and Florida	Deo,  Vishal,  Grover, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*| Interventions de sant&amp;eacute; publique	To stress upon the importance of extensive random testing for breaking the chains of transmissions, we have formulated a detailed framework for carrying out cost-effectiveness analysis (CEA) of extensive random testing in comparison to targeted testing (the existing testing policy followed by most countries).  Authors concluded that the proposed application methodology was successfully implemented to forecast the COVID-19 transmission in California and Florida, and further carry out CEA of extensive random testing over targeted testing.
Change in psychological distress in response to changes in reduced mobility during the early 2020 COVID-19 pandemic: Evidence of modest effects from the U.S	Devaraj,  S,  Patel, et al	Social Science and Medicine	Mental Health | santé mentale	To identify whether the change in state-level mobility is associated with the change in individuals’ reported psychological distress during the early COVID-19 pandemic and whether the intensity of the association varies by older individuals, females, and nonwhites. Study  findings show that reduced mobility from lockdowns during the early COVID-19 wave in the US is associated with a modest increase in reported psychological distress, especially for females. However, these conclusions should not be construed as a small increase in psychological distress in general, as a variety of non-mobility related factors associated with COVID-19 could have exacerbated psychological distress during the early COVID-19 wave in the US.
Clinically approved antiviral drug in an orally administrable nanoparticle for COVID-19	Dhar,  S,  Surnar, et al	ACS Pharmacology and Translational Science	Therapeutics| Thérapeutique	This study highlights the potential of ivermectin packaged in an orally administrable nanoparticle that could serve as a vehicle to deliver a more potent therapeutic antiviral dose and demonstrate its efficacy to decrease expression of viral spike protein and its receptor angiotensin-converting enzyme 2 (ACE2), both of which are keys to lowering disease transmission rates. The study revealed that ivermectin-loaded, orally administrable, biodegradable nanoparticles  can be a potential treatment option for the novel coronavirus through a multilevel inhibition.
Screening COVID-19 Based on CT/CXR Images & Building a Publicly Available CT-scan Dataset of COVID-19	Dialameh,  Maryam,  Hamzeh, et al	ArXiv	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	This study firstly builds a large-size publicly available CT-scan dataset, consisting of more than 13k CT-images of more than 1000 individuals, in which 8k images are taken from 500 patients infected with COVID-19. Secondly, we propose a deep learning model for screening COVID-19 using our proposed CT dataset and report the baseline results. Finally, we extend the proposed CT model for screening COVID-19 from CXR images using a transfer learning approach. The experimental results show that the proposed CT and CXR methods achieve the AUC scores of 0.886 and 0.984 respectively.
Examination of gene expression in saliva samples from COVID-19 patients to study the host defense response against SARS-CoV-2 in the oral cavity	Diamond,  G,  Figgins, et al	Molecular Oral Microbiology	Clinical data| Données cliniques Immunology | Immunologie	To examine the response of oral tissues to SARS‐CoV‐2 infection, we obtained saliva and buccal samples from patients with COVID‐19 and uninfected control individuals. Our result suggests that SARS‐CoV‐2 acts similarly in infected oral tissues, to downregulate ACE2 expression. We also examined the expression of the pro‐inflammatory cytokine IL‐6, and discovered that surprisingly, its expression was reduced in COVID‐19 patients .
Changes in demand for emergency ambulances during a nationwide lockdown that resulted in elimination of COVID-19: an observational study from New Zealand	Dicker,  B,  Swain, et al	BMJ Open	Healthcare Response | Réponse des soins de santé	This study aimed to examine the impact of a 5-week national lockdown on ambulance service demand during the COVID-19 pandemic in New Zealand. Despite the relative absence of COVID-19 in the community during the 5-week nationwide lockdown, there were significant differences in ambulance utilisation during this period. The lockdown was associated with an increase in ambulance attendances for mental health conditions and is of concern.
Probability-based approaches for identifying low-titer antibody responses against SARS-CoV-2	Dopico,  Xaquín Castro,  Hanke, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie	All subjects in a cohort of SARS-CoV-2 PCR+ individuals representing different disease severity categories (n=105), and a group of PCR+ hospital staff (n=33), developed IgG against pre-fusion-stabilized spike (S) trimers and 97% did against the receptor-binding domain (RBD). The levels differed by several orders of magnitude and associated with disease phenotype. Concomitant analysis of a cohort of healthy blood donors and pregnant women (n=1,000), representing individuals who had undergone milder infections, demonstrated highly variable IgG titers, including several that scored between the classical 3SD and 6SD cut-offs. Since the correct classification of seropositivity is critical for epidemiological estimates, we trained probabilistic algorithms to assign likelihood of past infection using anti-S and -RBD IgG data from PCR+ individuals and a large cohort of historical negative controls (n=595). Applied to blood donors and pregnant women, this probabilistic approach provided a more accurate way to interpret antibody titers spread over a large continuum offering a probability-based diagnosis.
Seropositivity in blood donors and pregnant women during 9-months of SARS-CoV-2 transmission in Stockholm, Sweden	Dopico,  Xaquin Castro,  Muschiol, et al	medRxiv	Epidemiology| Épidémiologie Immunology | Immunologie	In this cross-sectional prospective study, otherwise-healthy blood donors (n=2,100) and pregnant women (n=2,000) were sampled at random for consecutive weeks (at three intervals) between 14th March and 11th December 2020. After a steep rise at the start of the pandemic, the seroprevalence trajectory increased steadily in approach to the winter second-wave of infections, approaching 15% of all individuals surveyed by 11th December 2020. Importantly, 96% of antibody-positive healthy donors screened (n=56) developed neutralizing antibody responses at titers comparable to or higher than those observed in clinical trials of SARS-CoV-2 spike mRNA vaccination, supporting that mild infection engenders a competent B cell response.
Evolution of SARS-CoV-2 in the state of Alagoas-Brazil via an adaptive SIR model	Dos Santos,  IFF,  Almeida, et al	International Journal of Modern Physics C	Modelling/ prediction| Modélisation/prédiction Transmission	We investigate the spreading of SARS-CoV-2 in the state of Alagoas, northeast of Brazil, via an adaptive susceptible-infected-removed (SIR) model featuring dynamic recuperation and propagation rates. We provide with the evolution of the basic reproduction number R0 and reproduce the historical series of the number of confirmed cases with less than 10% error. We offer predictions, from November 16 forward, over the epidemic situation in the near future and show that it will keep decelerating.
Nationwide digital/virtual diabetes care of children, adolescents and young adults with type 1 diabetes during a covid-19 pandemic in Slovenia	Dovc,  K,  Osredkar, et al	Zdravniski Vestnik	Healthcare Response | Réponse des soins de santé	In this prospective observational study, we compared glycaemic control of children, adolescents and young adults with type 1 diabetes from the Slovenian National Childhood Type 1 Diabetes Registry during the pre-lockdown and lockdown periods.  n a short period of time, we established effective workflows to enable video digital/ virtual visits that provided individuals with type 1 diabetes good clinical support and prevented deterioration of this chronic condition and its acute complications during the lockdown due to the COVID-19 pandemic.
Multi-criteria risk evaluation model for developing ventilator-associated pneumonia	Drnovšek,  R,  Milavec Kapun, et al	Central European Journal of Operations Research	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	Using scientific and clinical practice knowledge, a risk evaluation model was developed to identify patients more at risk of developing the disease. For this purpose, a Decision Expert qualitative multi-criteria decision method was used, in which alternatives are evaluated according to predetermined hierarchically arranged criteria. Characteristics of each evaluated alternative are described by the members of an interdisciplinary expert team and are represented by the values of the basic criteria.  The designed model was tested using actual clinical data.
The neutralization effect of Montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies	Durdagi,  Serdar,  Avsar, et al	bioRxiv	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	In the current drug repurposing study, we identified the leukotriene (D4) receptor antagonist Montelukast as a novel agent that simultaneously targets two important drug targets of SARS-CoV-2. We initially demonstrated the dual inhibition profile of Montelukast through multiscale molecular modeling studies. Next, we characterized its effect on both targets by different in vitro experiments including the Fluorescent Resonance Energy Transfer (FRET)-based main protease enzyme inhibition assay, surface plasmon resonance (SPR) spectroscopy, pseudovirus neutralization on HEK293T / hACE2, and virus neutralization assay using xCELLigence MP real time cell analyzer. Our integrated in silico and in vitro results confirmed the dual potential effect of the Montelukast both on virus entry into the host cell (Spike/ACE2) and on the main protease enzyme inhibition.
The Effectiveness of Community-based Social Distancing for Mitigating the Spread of the COVID-19 Pandemic in Turkey	Durmuş,  H,  Gökler, et al	Journal of preventive medicine and public health = Yebang Uihakhoe chi	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	The objective of this study was to demonstrate the effects of community-based social distancing interventions after the first coronavirus disease 2019 (COVID-19) case in Turkey on the course of the pandemic and to determine the number of prevented cases.  Community-based social distancing interventions significantly decreased the Rt of COVID-19 by reducing human mobility, and thereby prevented many people from becoming infected.
A novel peptide analogue of spike glycoprotein shows antiviral properties against SARS-CoV-2: An in silico approach through molecular docking, molecular dynamics simulation and MM-PB/GBSA calculations	Dutta,  Kunal,  Elmezayen, et al	Research Square prepub	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Herein, we made an effort to find new antiviral peptides (AVPs) against SARS-CoV-2. Gladly, with the help of Machine Learning algorithms, and Supported Vector Machine, we have invented three new AVPs against the SARS-CoV-2. Antiviral peptides viz., Seq12, Seq12m, and Seq13m can block the receptor binding domain (RBD) of the SARS-CoV-2, necessary for communication with the angiotensin-converting enzyme 2 (ACE2). In addition, these AVPs retain their antiviral properties, even after the insertion of dozens of new mutations (Rosetta, and FoldX based) in the RBD. Further, Seq12, and Seq12m showed negligible cytotoxicity.
Gauging opinions about the COVID-19: a multi-channel social media approach	Eachempati,  P,  Srivastava, et al	Enterprise Information Systems	Public Health response| Interventions de santé publique	This study examines the impact of social media opinions through a multi-channel social media approach encompassing Twitter, Facebook and YouTube from February 10th to March 10th, 2020. A country-wise analysis is performed for both major developed and developing economies, like the US, India, China, Italy and Iran. The analysis reveals that public opinion is unanimously negative. The impact of the pandemic on businesses, society and education has been highlighted to help formulate country-specific strategies to mitigate stigmatization of people impacted by the virus.
Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial	Edalatifard,  M,  Akhtari, et al	Eur Respir J	Clinical data| Données cliniques Therapeutics| Thérapeutique RCT	We conducted a single-blind, randomised controlled clinical trial involving severe hospitalised patients with confirmed COVID-19 at the early pulmonary phase of the illness in Iran. The patients were randomly allocated in a 1:1 ratio by the block randomisation method to receive standard care with methylprednisolone pulse (intravenous injection, 250 mg·day(-1) for 3 days) or standard care alone. Our results suggest that methylprednisolone pulse could be an efficient therapeutic agent for hospitalised severe COVID-19 patients at the pulmonary phase.
Pulmonary barotrauma in mechanically ventilated coronavirus disease 2019 patients: A case series	Edwards,  JA,  Breitman, et al	Annals of Medicine and Surgery	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	This study aimed to describe the presentation, characteristics, and management of mechanically ventilated patients with COVID-19 who developed barotrauma. Of the 574 COVID-19 positive patients, 139 (24.2%) needed mechanical ventilation and 13 (9.4%) of those developed barotrauma. Majority of patients were Black race (92.3%), older than age 65 (56.8%), male (69.2%), and had comorbidities (76.9%). Most common presenting symptoms were cough (84.6%) and dyspnea (76.9%). Barotrauma presentations included 3/13 pneumothoraces and pneumomediastinum, 12/13 pneumomediastinum and subcutaneous emphysema, and 1/13 pneumothorax alone.
COVID-19 from the perspective of dentists: A case report and brief review of more than 170 cases	Eghbali Zarch,  R,  Hosseinzadeh, et al	Dermatol Ther	Clinical data| Données cliniques	Authors present a case that highlights oral lesions two days prior to the first COVID-19 general symptoms.
Development of a Low-Cost Cotton-Tipped Electrochemical Immunosensor for the Detection of SARS-CoV-2	Eissa,  S,  Zourob, et al	Anal Chem	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Here, we report a cotton-tipped electrochemical immunosensor for the detection of SARS-CoV-2 virus antigen. The limit of detection for our electrochemical biosensor was 0.8 pg/mL for SARS-CoV-2, indicating very good sensitivity for the sensor. The biosensor did not show significant cross-reactivity with other virus antigens such as influenza A and HCoV, indicating high selectivity of the method. Moreover, the biosensor was successfully applied for the detection of the virus antigen in spiked nasal samples showing excellent recovery percentages.
Simple mathematical models for controlling COVID-19 transmission through social distancing and community awareness	Elgazzar,  AhmedS	ArXiv	Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*| Interventions de santé publique	In this study, simple mathematical models were employed to examine the dynamics of transmission and control of COVID-19 taking into consideration social distancing and community awareness. Based on the calculations, a sufficient degree of social distancing based on its reproductive ratio is found to be effective in controlling COVID-19, even in the absence of a vaccine. With a vaccine, social distancing minimizes the sufficient vaccination rate to control the disease. Community awareness also has a great impact in eradicating the virus transmission. The model is simulated on small-world networks and the role of social distancing in controlling the infection is explained.
Tracy: Smartphone-based Contact Tracing Solution that Supports Self-investigation to Limit the Spread of COVID-19	Elmesalawy,  MM,  Salama, et al		Public health interventions*| Interventions de sant&amp;eacute; publique	In this paper, an innovative privacy preserving smartphone-based contact tracing solution named 'Tracy' is proposed to help the health facilities to limit and control the spread of COVID-19 especially with the upcoming second wave of the virus. The proposed system consists of three main components: an intelligent application installed on smartphones, a data processing platform, and a website on which the different functions of those parts are integrated to provide the required services for the contact tracing solution. The system is designed to allow individuals to investigate the possibility of them contacting a person infected with the emerging coronavirus. A novel algorithm is designed to determine the effective location points in the individual's routes in which possible contacts can happen and based on these effective points, the prior contacts are decided.
Comparison of in-hospital mortality risk prediction models from COVID-19	El-Solh,  A,  Lawson, et al	PLoS One	Epidemiology| Épidémiologie Clinical data| Données cliniques	Our objective is to compare the predictive accuracy of four recently established outcome models of patients hospitalized with COVID-19 published between January 1st and May 1st 2020. During the study period, 1634 unique patients were identified. Hypertension, hyperlipidemia, and heart disease were the most common comorbidities. The crude hospital mortality was 29% (95% CI 0.27-0.31). Evaluation of the predictive models showed an AUC range from 0.63 (95% CI 0.60-0.66) to 0.72 (95% CI 0.69-0.74) indicating fair to poor discrimination across all models. There were no significant differences among the AUC values of the four prognostic systems. All models calibrated poorly by either overestimated or underestimated hospital mortality.
Impact of COVID-19 pandemic on key performance indicators in pancreatobiliary endoscopy: Prioritise, minimise risk, keep scoping and training	Esmaily,  S,  Yau, et al	Frontline Gastroenterology	Healthcare Response | Réponse des soins de santé	The aim of the study was to assess the impact of COVID-19 pandemic on key performance indicators (KPIs) in endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasound (EUS) and ascertain the risk of procedure-related complications. Our study confirms that a high-quality PB endoscopy service can be delivered safely and effectively during the COVID-19 pandemic.
The Relationship between Ambient Temperature and Positive Cases of COVID-19; A Case Study in Abarkouh and Qeshm Cities of Iran	Fallahzadeh,  RA,  Ghadirian, et al	Journal of Environmental Health and Sustainable Development	Epidemiology| Épidémiologie	The aim of this study was to investigate the relationship between the ambient temperature and the positive cases of COVID 19. Our results revealed that increase of air temperature was negatively correlated with the number of positive cases of COVID 19. It can be concluded that atmospheric temperature affects the virus outbreak. So, the rate of virus spread is expected to be reduced.
Phylogenomics and phylodynamics of SARS-CoV-2 genomes retrieved from India	Farah,  S,  Atkulwar, et al	Future Virology	Epidemiology| Épidémiologie Coronavirology| Coronavirologie	This is the first phylodynamic study attempted on SARS-CoV-2 genomes from India to infer the current state of SARS-CoV-2 evolution using phylogenetic network and growth trends. Out of 286 retrieved whole genomes from India, 138 haplotypes were used to build a phylogenetic network. The phylogenetic network reveals dual ancestry and possibility of community transmission of SARS-CoV-2 in India.
Validation testing to determine the effectiveness of lateral flow testing for asymptomatic SARS-CoV-2 detection in low prevalence settings	Ferguson,  Jack,  Dunn, et al	medRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Here we present data on the performance of Lateral Flow devices to test almost 8,000 students at the University of Birmingham between December 2-9 2020. The performance is validated against almost 800 samples using PCR performed in the University Pillar 2 testing lab, and theoretically validated on thousands of Pillar 2 PCR testing results performed on low-prevalence care home testing samples. Our data shows that Lateral Flow Devices do not detect infections presenting with PCR Ct values over 29-30, meaning that only 3.2% (95% CI 0.6% to 15.6%) of total cases in the student population were detected, but that as many of 85% of cases tested in the Pillar 2 PCR lab would have been detected theoretically.
Views of patients with inflammatory bowel disease during the COVID-19 pandemic: ACCU survey results	Fernández Álvarez,  P,  Belvis Jiménez, et al	Rev Esp Enferm Dig	Epidemiology| Épidémiologie Public Health response| Interventions de santé publique	This study was performed with the aim to determine how the SARS-COV-2 pandemic has affected our IBD patients. 58% cases were female, 63.7 % had Crohn's disease (CD) and 53 % received biologic therapy. 5% were infected by SARS-CoV-2 and were male. The main concern of the patients was the fear of acquiring the infection (80.9 %). More than 90 % continued their treatments and half of the patients worked from home during the pandemic period.
Survival Prediction Algorithms for Covid-19 Patients Admitted to a UK District General Hospital	Fernandez,  A,  Obiechina, et al	Int J Clin Pract	Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	This study aimed to collect and review data from consecutive patients admitted to Queen's Hospital, Burton on Trent for treatment of Covid-19 infection, with the aim of developing a predictive algorithm that can help identify those patients likely to survive. Age, IpO2 on Admission, CRP, platelets and number of lungs consolidated were an effective marker combination that helped identify patients who would be likely to survive. The AUC under the ROC Plot was 0.8129 (95% CI 0.0.773 - 0.853; P< 0.001).
Small molecule stabilization of non-native protein-protein interactions of SARS-CoV-2 N protein as a mechanism of action against COVID-19	Fernández,  JF,  Lavecchia, et al	J Biomol Struct Dyn	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	In this study, the applicability of this unexplored mechanism of action against SARS-CoV-2 is analyzed. During our research, we were able to find three inducible interfaces of SARS-CoV-2 N protein NTD, compare them to the previously reported MERS-CoV stabilized dimers, and identify those residues that are responsible for their formation. A drug discovery protocol implemented consisting of docking, molecular dynamics and MM-GBSA enabled us to find several compounds that might be able to exploit this mechanism of action. In addition, a common catechin skeleton was found among many of these molecules, which might be useful for further drug design.
Real-world experience of ocrelizumab in multiple sclerosis in a Spanish population	Fernandez-Diaz,  E,  Perez-Vicente, et al	Ann Clin Transl Neurol	Epidemiology| Épidémiologie	We conducted a retrospective study including consecutive patients from nine public hospitals in south-eastern Spain who received ocrelizumab after it was approved. The most common adverse events reported were infusion-related reactions and infections, with the most common infections being urinary tract infections followed by upper respiratory infections and COVID-19.
Lack of skin manifestations in COVID-19 hospitalized patients during the second epidemic wave in Spain: a possible association with a novel SARS-CoV-2 variant – a cross-sectional study	Fernandez-Nieto,  D,  Ortega-Quijano, et al	Journal of the European Academy of Dermatology and Venereology	Clinical data| Données cliniques	COVID‐19 hospitalized patients, confirmed by rt‐PCR, were evaluated by three independent dermatologists on 16 October 2020 at Ramon y Cajal University Hospital. Thirteen patients (9.0%) received COVID‐19 treatments (excluding dexamethasone). Skin manifestations associated to COVID‐19 were present in five patients (3.5%), including one patient (0.7%) with maculopapular rash and four patients (2.8%) with livedoid lesions. Vesicular, urticarial and chilblain‐like lesions were absent.
Calcification of the thoracic aorta on low-dose chest CT predicts severe COVID-19	Fervers,  P,  Kottlors, et al	PLoS One	Epidemiology| Épidémiologie Clinical data| Données cliniques	The amount of aortic wall calcification (AWC) can be estimated on low-dose chest CT. We suggest quantification of AWC on the low-dose chest CT, which is initially performed for the diagnosis of COVID-19, to screen for patients at risk of severe COVID-19. AWC seems to be an independent biomarker for the prediction of severe progression and intensive care treatment of COVID-19 already at the time of patient admission to the hospital; verification in a larger multi-center, multi-vendor study is desired.
Alprostadil associated with low molecular weight heparin to treat limb ischemia caused by SARS-CoV2	Filho,  MABM,  Duarte Júnior, et al	Jornal Vascular Brasileiro	Clinical data| Données cliniques	This article reports the case of 60-year-old female patient who presented with mild flu symptoms, which turned out to be a SARS-CoV2 infection, and ended up developing arterial thrombosis with limb ischemia in a private care hospital in Sorocaba, São Paulo, Brazil.
Testicular Changes Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)	Flaifel,  A,  Guzzetta, et al	Arch Pathol Lab Med	Clinical data| Données cliniques	Here, we present our analysis of the morphologic features seen in testes obtained from patients with COVID-19. We did not detect the virus in the testes, which suggests that direct testicular injury by SARS-CoV-2 infection is unlikely.
PMC7725028; SARS-CoV-2, multiple sclerosis, and focal deficit in a postpartum woman: A case report	Florea,  AA,  Sirbu, et al	Exp Ther Med	Clinical data| Données cliniques	We report on a female patient who was treated with interferon beta 1a (IFNB-1a) for many years for relapsing-remitting multiple sclerosis (RRMS) until December 2018. She developed COVID 19 infection in April 2020, after giving birth to a healthy baby girl, five weeks before. She developed a mild right hemiparesis 2 weeks later, without cold symptoms. On admission, PCR for SARS-CoV-2 was positive, and she received antivirals and corticotherapy. One month later, specific IgG and IgM antibodies were negative.
Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein	Flower,  TG,  Buffalo, et al	Proc Natl Acad Sci U S A	Coronavirology| Coronavirologie	The crystal structure of SARS-CoV-2 ORF8 was determined at 2.04-Å resolution by X-ray crystallography. The structure reveals a ∼60-residue core similar to SARS-CoV-2 ORF7a, with the addition of two dimerization interfaces unique to SARS-CoV-2 ORF8.
The SARS-CoV-2 S1 spike protein mutation N501Y alters the protein interactions with both hACE2 and human derived antibody: A Free energy of perturbation study	Fratev,  Filip	bioRxiv	Coronavirology| Coronavirologie Immunology | Immunologie	Here, we present the preliminary results of our Free energy perturbation (FEP) and Molecular dynamics (MD) calculations for the interaction of the spike S1 receptor binding domain (RBD) with both the ACE2 receptor and an antibody, STE90-C11, derived from COVID-19 patients. The results shown that the S1 RBD-ACE2 interaction was increased whereas those with the STE90-C11 antibody significantly decreased (over about 160 times). This may explain the observed in UK more spread of the virus but also emerge an important question about the possible human immune response and already available vaccines. Indeed, the latter may still act well but our data indicate some possible reduction of their effect. Further studies of N501Y mutation are need.
Clinical Features of Patients Infected With Coronavirus Disease 2019 With Elevated Liver Biochemistries: A Multicenter, Retrospective Study	Fu,  Y,  Zhu, et al	Hepatology	Clinical data| Données cliniques	In this multicenter, retrospective study, we collected data on laboratory-confirmed patients with COVID-19 from three hospitals in Wuhan, China, who died or were discharged between February 1-20 2020. Elevated liver biochemistries were common in patients with COVID-19. Patients with hypoxia or severe inflammation are more likely to experience increased liver biochemistries on admission. Those with abnormal AST or TBIL on admission are more likely to suffer from severe complications and death.
PMC7685059; Mental Health Status of the Older Adults in Japan During the COVID-19 Pandemic	Fujita,  K,  Inoue, et al	J Am Med Dir Assoc	Mental Health | santé mentale	This study investigated the effects of the COVID-19 pandemic on older adults' mental status. Depression and apathy scores both significantly deteriorated in July 2020 compared with December 2019. Depression score values increased from a GDS-15 score of 2.94 ± 3.27 to 3.62 ± 3.41. pathy scores also escalated from 13.65 ± 6.70 to 15.20 ± 6.98.
L’impatto emotivo della comunicazione istituzionale durante la pandemia di covid-19: Uno studio di twitter sentiment analysis	Gagliardi,  G,  Gregori, et al		Public Health response| Interventions de santé publique	Article in Italian. This paper aims at investigating the impact of institutional communications during the health crisis due to Covid-19 pandemic in Italy, through the analysis of micro-blogging activities on Twitter by means of NLP techniques. We performed a Sentiment Analysis on the TWITA corpus, to pinpoint potential correlations between opinion polarity (positive or negative) of the users and public speeches during the outbreak. Our findings show changes in sentiment polarity related to three institutional speeches delivered by the Italian Prime Minister Giuseppe Conte on March, 4th, March, 9th, and April, 26th 2020.
The importance of continued non-pharmaceutical interventions during the upcoming SARS-COV-2 vaccination campaign	Galanti,  Marta,  Pei, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*| Interventions de sant&amp;eacute; publique	In this communication we assess the potential benefit of SARS-COV-2 pandemic vaccination in the US and show how continued use of non-pharmaceutical interventions (NPIs) will be crucial during implementation.
Designing a novel nano-vaccine against SARS-CoV-2	Gao,  A,  Liang, et al	Nano Biomedicine and Engineering	Vaccine Research| Recherche sur les vaccins Animal model | Modèle animal	In this study, we developed a new vaccine against the new coronavirus by combining our self-developed nano adjuvant loaded with carnosine graphene oxide adjuvant with loaded with CpG molecule and RBD protein antigen. Our results showed that this vaccine can produce high titer anti-SARS-CoV-2 RBD antibody neutralizing SARS-CoV-2 in mice within 2 weeks.
Cardiopulmonary Exercise Test might be Helpful For Insight Interpretation of Impaired Pulmonary Function on Recovered COVID-19 Patients	Gao,  Y,  Chen, et al	Eur Respir J	Long-Term Sequelae | séquelles à long terme	We performed the dynamic functional evaluation through cardiopulmonary exercise test (CPET) in 10 rehabilitated patients with COVID-19 (i.e. 3 moderate cases, 2 severe cases, 5 critical ill cases) 1-month post-discharge in our center between January to March 2020. Our result showed the spirometry was within the normal range in all cases and abnormal DLCO (<80% pred) was only found in 3 cases. However, noteworthy, all cases had reduction of the peak oxygen uptake (PeakVO2) and seven cases displayed decreasing oxygen pulse of predicted (VO2/HR%pred). On the contrary, 8 cases displayed normal ventilatory equivalents for carbon dioxide at anaerobic threshold (VE/VCO2@AT). This indicated pulmonary dysfunction and gas transfer inefficiency was not the sole reason for exercise limitation of patients with COVID-19, extrapulmonary factors especially the cardiac dysfunction after long-term bed rest during hospitalisation should be concerned.
Laboratory parameters as predictors of mortality in COVID-19 patients on hospital admission	Garciá-Tardón,  N,  Abbes, et al	Journal of Laboratory Medicine	Epidemiology| Épidémiologie Clinical data| Données cliniques	In this study we present the laboratory characteristics from 382 adult patients admitted with COVID-19 to Isala Hospital, the largest Dutch referral hospital located in the Northern area of the Netherlands, from March 12th (first case admitted) up to April 14th 2020. Our aim was to identify predictors of mortality based on the laboratory results on admission. Several significant differences in laboratory values were noted between the non-survivor and survivor group on admission, especially encompassing higher values of creatine kinase (CK) (2.7-fold), lactate dehydrogenase (LDH) (1.6-fold), C-reactive protein (CRP) (1.6-fold), aspartate aminotransferase (AST) (1.4-fold), creatinine (1.3-fold), glucose (1.1-fold) and higher absolute neutrophil counts (1.1-fold)
Mining user reviews of COVID contact-tracing apps: An exploratory analysis of nine European apps	Garousi,  Vahid,  Cutting, et al	ArXiv	Public Health response| Interventions de santé publique	Our goal is to gain insights into the user reviews of those apps, and to find out the main problems that users have reported. Our focus is to assess the "software in society" aspects of the apps, based on user reviews. We selected nine European national apps for our analysis and used a commercial app-review analytics tool to extract and mine the user reviews. For all the apps combined, our dataset includes 39,425 user reviews. Results show that users are generally dissatisfied with the nine apps under study, except the Scottish ("Protect Scotland") app. Some of the major issues that users have complained about are high battery drainage and doubts on whether apps are really working.
Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models	Garvin,  MR,  E, et al	Genome Biol	Coronavirology| Coronavirologie	Here we identify globally distributed haplotypes from 15,789 SARS-CoV-2 genomes and model their success based on their duration, dispersal, and frequency in the host population. Our models identify mutations that are likely compensatory adaptive changes that allowed for rapid expansion of the virus.
Do People Actually "Listen to the Experts"? A Cautionary Note on Assuming Expert Credibility and Persuasiveness on Public Health Policy Advocacy	Geiger,  N	Health Commun	Public Health response| Interventions de santé publique	The present work empirically explores whether experts are trusted more or more persuasive than an "average Joe" when engaging in policy advocacy on public health topics. I conducted a 2 (topic: climate change vs. COVID-19) X 2 (source: expert vs. nonexpert) experimental study with an US adult sample (N = 486).  Using Bayes factors to quantify evidence for null and alternative hypothesis, I find substantial evidence that at least under the conditions present in the study, experts are perceived to be higher in expertise, but equal in trustworthiness to the "average Joe".
Recent smell loss is the best predictor of COVID-19 among individuals with recent respiratory symptoms	Gerkin,  RC,  Ohla, et al	Chem Senses	Epidemiology| Épidémiologie Clinical data| Données cliniques	We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n=4148) or negative (C19-; n=546) COVID-19 laboratory test outcome. Both C19+ and C19- groups exhibited smell loss, but it was significantly larger in C19+ participants. Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC=0.72). Olfactory recovery within 40 days of respiratory symptom onset was reported for ~50% of participants and was best predicted by time since respiratory symptom onset. We find that quantified smell loss is the best predictor of COVID-19 amongst those with symptoms of respiratory illness.
Psychological impacts of COVID-19 pandemic on the university students in Egypt	Ghazawy,  ER,  Ewis, et al	Health Promot Int	Mental Health | santé mentale	The aim of this study was to investigate the psychological impacts that affected the university students in Egypt during the COVID-19 pandemic. Overall, 70.5, 53.6 and 47.8% of Egyptian students had depression, anxiety and stress, respectively. Being a female, having a relative or acquaintance infected with COVID-19, having a preexisting chronic disease and lacking of psychological support from families, community and universities increase the risk of depression, anxiety and stress among Egyptian students.
Spontaneous massive pneumopericardium in a patient with COVID-19	Ghods,  K,  Aghaamoo, et al	Eur J Cardiothorac Surg	Clinical data| Données cliniques	An 82-year-old man presented with dyspnoea, cough, fever and malaise. Symptoms and laboratory tests confirm the COVD-19 disease.
Parenting in a Pandemic: Work–Family Arrangements, Well-Being, and Intimate Relationships Among Adoptive Parents	Goldberg,  AE,  McCormick, et al	Family Relations	Mental Health | santé mentale Public Health response| Interventions de santé publique	This mixed-methods study aimed to address how 89 adoptive parents (lesbian, gay, heterosexual) with school-age children are navigating a major public health crisis with social, economic, and mental health consequences. Concerns related to the pandemic included worries about health and children's emotional well-being and global concerns such as the national economy. Almost half reported declines in mental health (e.g., due to the stress of working and homeschooling), with lesbians being significantly more likely than others to report declines.
Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus (SARS-CoV-2)	Gonçalves,  TJM,  Gonçalves, et al	Nutr Clin Pract	Epidemiology| Épidémiologie Clinical data| Données cliniques	We verify the prevalence of low zinc levels among critically ill patients infected by SARS‐CoV‐2 in the intensive care unit (ICU) who required invasive mechanical ventilation, as well as its association with severity of acute respiratory distress syndrome (ARDS). A total of 269 patients met inclusion criteria; 51.3% were men; median age was 74 (66-81) years; 91.1% (245 of 269) were elderly. The median BMI was 30.1 (24.7-32.1) kg/m(2) , with 59.9% (161 of 269) of patients having overweight and obesity. The prevalence of low zinc levels was 79.6% (214 of 269) and severe ARDS was 56.5% (152 of 269). There was an association of low zinc levels and severe ARDS (odds ratio OR], 14.4; 95% CI, 6.2-33.5; P < .001), even after adjusting for baseline variables (OR, 15.4; 95% CI, 6.5-36.3; P < .001).
Detection of methylene blue residue and its application in the preparation of anti-SARS-CoV-2 virus-inactivated plasma	Gong,  Q,  Yu, et al	Chinese Journal of New Drugs	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	This study aimed to establish a detection method for the methylene blue residues in inactivated plasma against SARS-CoV-2, and to apply the method to inactivated plasma of different dosages. The method can be successfully applied for the detection of methylene blue residues in the inactivated plasma against SARS-COV-2 of different specifications.
Experience in autopsies of deceased with covid-19 in the central military hospital “dr. Luis díaz soto”	González,  TM,  Amat, et al	Revista Cubana de Medicina Militar	Epidemiology| Épidémiologie Clinical data| Données cliniques	Article in Spanish. This study aimed to identify the demographic characteristics, concomitant diseases and morphological alterations found in the autopsies of deceased confirmed to COVID-19. The age groups most affected were between 70 and 79 years old with equivalence in both sexes. Comorbidities contribute to worsening the prognosis of these deceased, with a predominance of arterial hypertension and diabetes mellitus. The manifestations of the systemic inflammatory response present as complications in them. Mortality from COVID-19 as a cause of death affected less than half of the cases studied, with respiratory and cardiac expression due to the action of the virus.
Mortality of covid-19 patients with vascular thrombotic complications	Gonzalez-Fajardo,  J,  Ansuategui, et al	Medicina clinica	Epidemiology| Épidémiologie Clinical data| Données cliniques	Article in Spanish. This study aimed to analyze the survival of patients hospitalized with covid-19 and who presented some vascular thrombotic complication.  The venous thromboembolic risk in these patients is greater than the arterial, but arterial thrombosis when it occurs was associated with high mortality rates. Survival was better in patients with DVT and PE than in patients with ischemic stroke or PAT.
New coronavirus infection covid-19: Features of the course in children in the russian federation	Gorelov,  AV,  Nikolaeva, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study aimed to determine clinical and epidemiological features of the course of COVID-19 caused by SARS-CoV-2 in children in the Russian Federation (RF). In children, the maximum number of cases is registered in family foci – 75%. Upper respiratory tract infections were diagnosed in 72,1% of patients. The proportion of pneumonia was 1,8%, and2/3 of children were over 3 years old (p<0,001). In almost1/3 of patients, the infection course had no clinical manifestations. 18,2% of children at the disease onset had increased body temperature, while only 3,5% of children had hyperthermia above 390 C. Cough was registered in 50,8% of cases. Rhinitis/rhinopharyngitis developed only in every 4th child. Symptoms pathognomonic for COVID-19, such as loss of smell (anosmia) and taste (ageusia), were recorded only in 17% of cases. 41,3% of patients received treatment in a hospital, and among them children under 3 years of age predominated.
Peripheral and lung resident T cell responses against SARS-CoV-2	Grau-Expósito,  Judith,  Sánchez-Gaona, et al	medRxiv	Clinical data| Données cliniques Immunology | Immunologie	Here, we demonstrate that viral specific T cells can migrate and establish in the lung as resident memory T cells, being detectable beyond 7 months in convalescent COVID-19 patients. Moreover, focusing on the acute phase of the infection, we identified virus-specific T cell responses in blood with functional, migratory and apoptotic patterns modulated by viral proteins and associated with clinical outcome. Our study highlights IL-10 secretion by virus-specific T cells associated to a better outcome and the persistence of resident memory T cells as key players for future protection against SARS-CoV-2 infection.
Covid-19: The ivermectin african enigma	Guerrero,  R,  Bravo, et al	Colombia Medica	Epidemiology| Épidémiologie	Our study aimed to describe SARS-CoV2 infection and death rates in African countries that participated in an intensive Ivermectin mass campaign carried out to control onchocerciasis and compare them with those of countries that did not participate. The incidence in mortality rates and number of cases is significantly lower among the African Programme for Onchocerciasis Control (APOC) countries compared to non-APOC countries. That a mass public health preventive campaign against COVID-19 may have taken place, inadvertently, in some African countries with massive community ivermectin use is an attractive hypothesis.
Perceptive changes in endurance athletes during social isolation due to covid-19	Guilherme,  FR,  Do Nascimento, et al	Revista Brasileira de Medicina do Esporte	Mental Health | santé mentale Public Health response| Interventions de santé publique	This study aimed to assess potential associations between stress, motivation, behavioral changes, and physical fitness in endurance athletes, and time in social isolation. Social isolation was significantly associated with at least one variable for the three groups of athletes; however, the runners were the most affected by the pandemic, presenting an association with low motivation, high stress, poorer quality of sleep, increased alcohol consumption, and loss of physical fitness.
Vessel wall enhancement and focal cerebral arteriopathy in a pediatric patient with acute infarct and COVID-19 infection	Gulko,  E,  Overby, et al	American Journal of Neuroradiology	Clinical data| Données cliniques	Herein, we report the findings of intracranial arterial wall enhancement, consistent with focal cerebral arteriopathy-inflammatory type, in a child presenting with acute infarct in the setting of COVID-19 infection.
Analysis and Visualization of Novel Coronavirus Pneumonia Based on Python	Guo,  F,  Liu, et al		Clinical data| Données cliniques Therapeutics| Thérapeutique	Through crawling 227 prescriptions of Xinguan TCM collected by Huabing data website intelligent TCM big data platform, we analyzed the web page data by using word cloud analysis, data visualization and the third-party library lxml and request of Python. High frequency of drug use of traditional Chinese medicine are: Huoxiang, Atractylodes, Platycodon, honeysuckle, astragalus, Scutellaria, Atractylodes macrocephala, etc. The analysis of clinical symptoms showed that the most common symptoms were fatigue, fever, white fur, cough, chest tightness, diarrhea and so on.
Factors influencing social distancing to prevent the community spread of COVID-19 among Chinese adults	Guo,  Y,  Qin, et al	Prev Med	Mental Health | santé mentale Public Health response| Interventions de santé publique	The purpose of the present study is to identify individual and environmental factors related to individuals' compliance with the recommended social distancing, as well as the moderating role of social media in influencing individuals' implementation of social distancing. A total of 2130 Chinese adults were surveyed in March 2020 during the COVID-19 pandemic. Overall, the majority of respondents (95.6%) reported compliance with social distancing. Women were more likely to practice social distancing compared to men (OR = 3.12, 95% CI = 1.93-5.02). Psychological distress, depressive symptoms, and social media were significant predictors of social distancing after controlling for other individual and environmental factors. Social media moderated the effects of psychological distress on social distancing (OR = 0.96, 95% CI = 0.94-0.99).
Real-time analysis of COVID-19 pandemic on most populated countries worldwide	Gupta,  M,  Jain, et al	CMES - Computer Modeling in Engineering and Sciences	Epidemiology| Épidémiologie	The objective of this research work is to make a comparative analysis of the top 5 most populated countries namely United States, India, China, Pakistan and Indonesia, from 1st January 2020 to 31st July 2020. This research work also targets to predict an increase in the number of deaths and total infected cases in these five countries. In our research, the performance of the proposed framework is determined by using three Machine Learning (ML) regression algorithms namely Linear Regression (LR), Support Vector Regression (SVR), and Random Forest (RF) Regression. The proposed model is also validated upon the infected and death cases of further dates.
Characteristics of SARS-CoV-2 Testing for Rapid Diagnosis of COVID-19 during the Initial Stages of a Global Pandemic	Guthrie,  JenniferL,  Chen, et al	medRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	From January 11 – April 22, 2020, Public Health Ontario conducted SARS-CoV-2 testing of 86,942 specimens collected from 80,354 individuals, primarily using real-time reverse-transcription polymerase chain reaction (rRT-PCR) methods. We analyzed test results across specimen types and for individuals with multiple same-day and multi-day collected specimens. Nasopharyngeal compared to throat swabs had a higher positivity (8.8% vs. 4.8%) and an adjusted estimate 2.9 Ct lower (SE=0.5, p<0.001). Same-day specimens showed high concordance (98.8%), and the median Ct of multi-day specimens increased over time. Symptomatic cases had rRT-PCR results with an adjusted estimate 3.0 Ct (SE=0.5, p<0.001) lower than asymptomatic/pre-symptomatic cases. Overall test sensitivity was 84.6%, with a negative predictive value of 95.5%.
South Korea as the Role Model for Covid-19 Policies? An Analysis of the Effect of Government Policies on Infection Chain Structures	Haberling,  A,  Laurisch, et al		Transmission Public health interventions*| Interventions de sant&amp;eacute; publique	Concerning the risks and the negative effects inflicted by the spread of the pandemic, many countries established a series of policies reinforcing public protection from the virus. With respect to these policies, this study characterizes the infection chain structure in Korea and identifies changes in the structure over time. Furthermore, using multiple linear regressions, the impact of government policy interventions on the infection chain structure is measured. The analysis shows a high fluctuation in infection chain structures at the beginning of the pandemic, which decreases with the implemented policies.
Emergency center curbside screening during the COVID-19 pandemic: Retrospective cohort study	Halalau,  A,  Ditkoff, et al	JMIR Public Health and Surveillance	Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé	We describe the emergency center curbside testing procedure implemented at Beaumont Hospital, a large hospital in Royal Oak, MI, and aim to evaluate its safety and efficiency. In total, 2782 patients received curbside services. A nasopharyngeal swab was performed on 1176 patients (41%), out of whom 348 (29.6%) tested positive. The median time for the entire process (from registration to discharge) was 28 minutes (IQR 17-44). The median time to final medical decision was 15 minutes (IQR 8-27). The median time from medical decision to discharge was 9 minutes (IQR 5-16). Only 257 patients (9.2%) returned to the emergency center for an evaluation within 7 or more days, of whom 64 were admitted to the hospital, 11 remained admitted, and 4 expired.
Spatial distribution characteristics of the COVID-19 pandemic in Beijing and its relationship with environmental factors	Han,  Y,  Yang, et al	Science of the Total Environment	Epidemiology| Épidémiologie	This study aims to analyze the spatial distribution characteristics of COVID-19 pandemic in Beijing and its relationship with the environmental factors. Based on the incidences of new local COVID-19 cases in Beijing from June 11 to July 5, the spatial clustering characteristics of the COVID-19 pandemic in Beijing was investigated using spatial autocorrelation analysis. The results showed that the development of COVID-19 pandemic in Beijing from June 11 to July 5 could be divided into two stages. The first stage was the outward expansion from June 11 to June 21, and the second stage (from June 22 to July 5) was the growth of the transmission in areas with existing previous cases. In addition, there was a ring of low value clusters around the Xinfadi market.
The impact of the SARS-CoV-2 pandemic and COVID-19 on Lung Transplantation in the UK: lessons learned from the first wave	Hardman,  G,  Sutcliffe, et al	Clin Transplant	Healthcare Response | Réponse des soins de santé	A retrospective review of the UK Transplant Registry (UKTR) and national survey of UK lung transplant centres has been performed. There was geographic variation in the prevalence of COVID-19 infection across the UK. The number of donors fell by 48% during the early pandemic period. Lung utilisation fell to 10% (compared to 24% for the same period of 2019). The number of lung transplants performed fell by 77% from 53, March to May 2019, to 12.
Covid-19: A killer with »silent hypoxemia«	Harlander,  M,  Tomažič, et al	Zdravniski Vestnik	Clinical data| Données cliniques	We present two cases of patients with covid-19 pneumonia, silent hypoxemia, and rapidly progressing respiratory failure. Possible pathophysiological mechanisms are discussed.
Covid-19 fever symptom detection based on IoT cloud	Hasan,  MW	International Journal of Electrical and Computer Engineering	Clinical data| Données cliniques	This paper presents a new method of detection Covid-19 fever symptoms depending on IoT cloud services to solve the higher time delay of checking the crowded clients that enter public or private agencies which can lead to a dangerous field to spread the disease. An automatically checking process is suggested using a practical experiment is developed using (ESP8266 node MCU, ultrasonic (SR-04), RFID (RC522), human body temperature (MAX30205) sensors, and ThingSpeak platform). Where node MCU is open-source hardware used to transmit the received data (human temperature sensor) from the (MAX30205) to the cloud platform (ThingSpeak) then alert the monitoring manager user when the collected data reached a critical value that specified previously and automatically take action to solve this situation. At the same time, the cloud platform will provide a graphical representation of the received data to display it using different monitoring devices such as (computers, mobiles, and others).
COVID-19 Detection System using Recurrent Neural Networks	Hassan,  A,  Shahin, et al		Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In this study, we highlight the importance of speech signal processing in the process of early screening and diagnosing the COVID-19 virus by utilizing the Recurrent Neural Network (RNN) and specifically its significant well-known architecture, the Long Short-Term Memory (LSTM) for analyzing the acoustic features of cough, breathing, and voice of the patients. Our results show a low accuracy in the voice test compared to both coughing and breathing sound samples. Moreover, our results are preparatory, and there is a possibility to enhance the accuracy of the voice tests by expanding the data set and targeting a larger group of healthy and infected people.
A Controllability Algorithm to Minimize the Spreading chance of COVID-19 in Individual Networks	Hassan,  AM,  Talib Hasson, et al		Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*| Interventions de sant&amp;eacute; publique	This paper aims to present a model that computes controllability on real contact people's networks to reduce touches and keep the network in a controlled manner based on three ways. a structural controllability approach is using by applying the Bipartite-graph algorithm and the Hopcroft-Karp algorithm. In order to determine the drive nodes that must be controlled to gain full control of the network, normal driver nodes and weak driver nodes. Weak driver nodes can remove to enhance controllability. As a result, network controllability increased by 12.8%, reduced rate of drive nodes, reduced the chance of spread of infection by 67%.
Anxiety and Depression in Health Workers and General Population During COVID-19 in IRAN: A Cross-Sectional Study	Hassannia,  L,  Taghizadeh, et al	Neuropsychopharmacol Rep	Mental Health | santé mentale	The aim of this study was to determine the effect of pandemic on anxiety and depression in Iranian population. Of the 2045 participants, 1136 (65.6%) were considered to have moderate and severe anxiety symptoms, and 865 (42.3%) had moderate and severe depression symptoms. The prevalence of anxiety was higher in the females than in the males (OR = 1.4, 95% CI: 1.123-1.643, P = .002); the prevalence of anxiety was significantly higher in those aged 30-39 years than in other age-groups (OR = 1.6, 95% CI: 1.123-2.320, P = .001); furthermore, the prevalence of anxiety and depression was significantly higher in doctors and nurses compared with other occupations (OR = 1.9, 95% CI: 1.367-2.491, P < .001) and (OR = 1.5, 95% CI: 1.154-2.021, P = .003).
Inference of COVID-19 epidemiological distributions from Brazilian hospital data: Inference of COVID-19 epidemiological distributions from Brazilian hospital data	Hawryluk,  I,  Mellan, et al	Journal of the Royal Society Interface	Epidemiology| Épidémiologie	We determine epidemiological distributions for patients hospitalized with COVID-19 using a large dataset (N = 21 000 - 157 000) from the Brazilian Sistema de Informação de Vigilância Epidemiológica da Gripe database. A joint Bayesian subnational model with partial pooling is used to simultaneously describe the 26 states and one federal district of Brazil, and shows significant variation in the mean of the symptom-onset-to-death time, with ranges between 11.2 and 17.8 days across the different states, and a mean of 15.2 days for Brazil. Our results show that epidemiological distributions have considerable geographical variation, and provide the first estimates of these distributions in a low and middle-income setting. At the subnational level, variation in COVID-19 outcome timings are found to be correlated with poverty, deprivation and segregation levels, and weaker correlation is observed for mean age, wealth and urbanicity.
Targeting COVID-19 prevention in hemodialysis facilities is associated with a drastic reduction in central venous catheter-related infections	Heidempergher,  M,  Sabiu, et al	J Nephrol	Healthcare Response | Réponse des soins de santé	During the COVID-19 pandemic, hygienic precautions for preventing viral transmission have been markedly reinforced. We evaluated their effects on central venous catheter (CVC) related infection rates. The observed 91% reduction in catheter-related bloodstream infections compared to the same period in 2019 IRR 0.09 (95% CI 0.002-0.64)] and the 83% reduction compared to the whole of 2019 IRR 0.17 (95% CI 0.004-1.009)] suggest that a stricter implementation of hygienic precautions in the dialysis setting can markedly improve the problem of CVC-related infections.
Case 40-2020: A 24-Year-Old Man with Headache and Covid-19	Heller,  HM,  Gonzalez, et al	N Engl J Med	Clinical data| Données cliniques	A 24-Year-Old Man with Headache and Covid-19.
Evolution of COVID-19 Patients Treated With ImmunoFormulation, a Combination of Nutraceuticals to Reduce Symptomatology and Improve Prognosis: a Multi-centred, Retrospective Cohort Study	Hernández,  Mariana Díaz,  Urrea, et al	Research Square prepub	Clinical data| Données cliniques Therapeutics| Thérapeutique	In this paper, we describe a multicentre, retrospective, observational study to describe the course of SARS-CoV-2 disease in patients treated with ImmunoFormulation (IF), an add-on therapy developed to decrease duration of clinical symptoms. Throughout the observational period, 90% of patients recovered in the IF cohort and 47.4% in the Control cohort (p=0.0057). From the symptoms with statistically significant differences, the duration of symptoms (i.e., the time to recover from it) was shorter in the IF cohort than in control cohort (in days, average), especially for fever (2.25 x 21.78), dry cough (4.38 x 24.00), dyspnoea (3.67 x 20.00), headache (2.00 x 26.50), diarrhoea (5.25 x 25.25), and weakness (1.92 x 23.30).
Care Pathway And Prioritization Of Rapid Testing For Covid-19 In UK Hospitals: A Qualitative Evaluation	Hicks,  Timothy,  Winter, et al	Research Square prepub	Healthcare Response | Réponse des soins de santé	This study sought to understand the care pathways in place in UK NHS hospitals during the first wave (March-July 2020) for identification of patients with COVID-19 and to learn lessons to inform optimal testing strategies within the COVID-19 National Diagnostic Research and Evaluation Platform (CONDOR). During the winter months, priority for provision of rapid testing at admission should be given to hospitals with limited access to laboratory services and single room availability. Access to rapid testing is essential for urgent decisions related to emergency surgery, maternity services and organ transplant. The pathway and prioritization of need will inform the economic modelling, clinical evaluations, and implementation of new clinical tests in UK.
The impact of the corona pandemic on working life of young family physicians an online survey among members of jade (Junge allgemeinmedizin deutschland)	Hilbert,  B,  Krauthausen, et al	Zeitschrift fur Allgemeinmedizin	Healthcare Response | Réponse des soins de santé	The survey evaluated workload, salary, availability of protective equipment and fears regarding an infection with the SARS-CoV-2 virus. About two thirds of the participants considered an infection with the SARS-CoV-2 virus during work to be a probable risk. Half of the doctors in specialty training reported a worse learning situation.
Immune deficiency is a risk factor for severe COVID-19 in people living with HIV	Hoffmann,  C,  Casado, et al	HIV Med	Epidemiology| Épidémiologie Clinical data| Données cliniques	This multicentre cohort study evaluated risk factors for morbidity and mortality of COVID-19 in people living with HIV (PLWH), infected with SARS-CoV-2 in three countries in different clinical settings. COVID-19 was clinically classified as to be mild-to-moderate or severe. In PLWH, immune deficiency is a possible risk factor for severe COVID-19, even in the setting of virological suppression. There is no evidence for a protective effect of PIs or tenofovir alafenamide.
Epidemic dynamic model based evaluation of effectiveness of prevention and control strategies for COVID-19 in Ningbo	Hong,  H,  Shi, et al	Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	Article in Chinese. This study aimed to evaluate effectiveness of prevention and control strategies for COVID-19 in Ningbo by using an epidemic dynamic model. The infection rates in contacts with home quarantine and centralized quarantine were 0.1% and 0.3%, respectively. The basic reproduction number was estimated to be 4.8. With the strengthening of prevention and control measures, real-time reproduction number showed a gradual downward trend, dropping to below 1.0 on 4 February, and then continued to drop to 0.2 in mid-February.
Prediction of 2019-nCoV Epidemic by Linear Regression Model	Hong,  Z		Epidemiology| Épidémiologie	In this paper, a linear regression model was used to analyze and predict the death toll of the novel corona virus (2019-nCov) outbreaks in 2019. Besides, an improved linear regression method was proposed to obtain a more accurate epidemic prediction model. In this paper, the author used one parameter to predict the data. Therefore, in the further research, more factors will be added to conduct a more accurate prediction.
Cooperation or Confrontation? —— Prediction of COVID-19 Pandemic Situation via Deep Learning	Hong,  Zhonghua,  Fan, et al	Research Square prepub	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	To more accurately observe the epidemic under the influence of policies and provide policy adjustments before the official presidential transition in the United States, we use a three-layer superimposed Long-Short-Term-Memory (LSTM) model to predict the epidemic development trend to mid-January, 2021. According to forecasts, the epidemic situations in the United States, India, and Brazil, caused by untimely, inappropriate policies, lax regulations and insufficient public cooperation, remain very severe, with cases continuing to increase by tens of thousands. The number of cumulative confirmed cases worldwide will exceed 84.58 million by mid-January, 2021; however, the mortality rate will gradually decrease. Based on analysis of measures (including China’s effective prevention and control policies), we found that there are performed tremendous different efficiency even using same positive policy for different countries because of various cooperation between people and governments.
Can age-distribution be an indicator of the goodness of COVID-19 testing?	Hoseinpour Dehkordi,  Amirhoshang,  Nemati, et al	medRxiv	Epidemiology| Épidémiologie Transmission	In this paper, first of all, we will investigate the relation of transmission of COVID-19 with age by observing timed data in multiple countries. Then, we compare the COVID-19 CFR with the age-demography data. and as a result, we have proposed a method for estimating a lower bound for the number of positive cases by using the reported data on the oldest age group and the regions' population age-distributions. Using the publicly accessible data for several developed countries, we show how the improvement of testing over the course of several months has made it clear for the community that different age groups are equally prone to becoming COVID positive. The result shows that the age demography of COVID-19 gets similar to the age-demography of the population, together with the reduction of CFR over time. In addition, countries with less CFR have more similar COVID-19's age-distribution, which is caused by more comprehensive testing, than ones who have higher CFR.
Hospital Presentations of Acute Diverticulitis During COVID-19 Pandemic may be More Likely to Require Surgery due to Increased Severity: A Single-Centre Experience	Hossain,  N,  Naidu, et al	Am Surg	Healthcare Response | Réponse des soins de santé	The purpose of this study was to assess the severity of disease at presentation and quantify the change in number of presentations during this period. During the COVID-19 pandemic, fewer patients presented and were diagnosed with acute diverticulitis. A significantly greater proportion presented at a more advanced stage and required emergency surgery, suggesting late presentation. Our findings support the need for maintaining acute surgical services and the provision of early radiological and surgical input in patients presenting with signs and symptoms of acute diverticulitis in future pandemics.
Which information sources do people choose during the COVID-19 pandemic: Mass media or social media? A survey in Iran	Hosseini,  S,  Mohsenpour, et al	Pakistan Journal of Medical and Health Sciences	Public Health response| Interventions de santé publique	This study aimed to investigate the options for individuals to obtain news and knowledge about COVID-19 pandemic and the adequacy and trust of sources from their point of view in the center of Iran. The results showed that 188 people (49.3%) used the mass media, 180 people (47.2%) used social networks and the rest used other sources, including print sources, health center training and family or friends to increase their knowledge on COVID-19. Younger age individuals were more likely to choose social media, and middle-aged and older people were more likely to obtain information from the mass media (P <0.001). In the case of social media, Instagram was the most frequently used one to get information without any difference between age groups. 83.5% participants stated that they have high confidence in the information obtained from the above-mentioned news sources.
Interpersonal psychotherapy-based psychological intervention for patient suffering from COVID-19: A case report	Hu,  CC,  Huang, et al	World Journal of Clinical Cases	Clinical data| Données cliniques	This report describes a case of COVID-19 in a patient who transmitted the disease to his entire family. The patient received four sessions of IPT-based psychological intervention. We used the Hamilton Rating Scale for Depression and Patient Health Questionnaire to measure depression level, and the Hamilton Anxiety Scale and Generalized Anxiety Disorder to measure anxiety among the patients.
SARS-CoV-2 serosurveillance in a patient population reveals differences in virus exposure and antibody-mediated immunity according to host demography and healthcare setting	Hughes,  EC,  Amat, et al	J Infect Dis	Epidemiology| Épidémiologie Immunology | Immunologie	Serial cross-sectional serosurvey throughout the first pandemic wave among patients from the largest health board in Scotland. Screening of 7480 patient sera showed a weekly seroprevalence ranging from 0.10% to 8.23% in primary and 0.21% to 17.44% in secondary care, respectively.
Quantifying the Impact of Public Perceptions on Vaccine Acceptance Using Behavioral Economics	Hursh,  SR,  Strickland, et al	Frontiers in Public Health	Vaccine Research| Recherche sur les vaccins Public Health response| Interventions de santé publique	June 2020, 534 respondents completed online validated behavioral economic procedures adapted to evaluate COVID-19 vaccine demand in relation to a hypothetical development process and efficacy.  At 50% efficacy, 68.8% of respondents would seek the standard vaccine, and 58.8% would seek the rapid developed vaccine. Rapid vaccine development increased the minimum required efficacy for vaccine acceptance by over 9 percentage points, γ = 9.36, p < 0.001. Past-3-year flu vaccination, γ = −23.00, p < 0.001, and male respondents, γ = −4.98, p = 0.037, accepted lower efficacy. Respondents reporting greater conspiracy beliefs, γ = 0.39, p < 0.001, and political conservatism, γ = 0.32, p < 0.001, required higher efficacy. Male, γ = −4.43, p = 0.013, and more conservative, γ = −0.09, p = 0.039, respondents showed smaller changes in minimum required efficacy by development process.
Modeling the effect of population density on controlling Covid-19 initial Spread with the use of MATLAB numerical methods and stringency index model	Ibrahim,  AM,  Mohammed Eid, et al		Epidemiology| Épidémiologie	Finally, population density was found to be not a significant contributor in controlling Covid-19 epidemic in the very first month of spread; however, countries with denser populations were found better to adopt stricter regulations especially in the first month of spread as Covid-19 outbreak
The COVID-19 Pandemic And Dental Residency Training In Nigeria	Isiekwe,  IG,  Umeizudike, et al	Eur J Dent Educ	Healthcare Response | Réponse des soins de santé	Nigeria: A total of 104 dental residents participated in the study from ten residency training institutions in the country with a mean age of 35.65±4.8 years. Almost all 98(94.2%) of the residents showed a good knowledge of COVID 19. About two-thirds, 72(69.2%) of the participants were mostly worried about COVID-19 affecting their residency training program 72(69.2%), with their greatest source of worry being the risk of contracting the virus in the dental clinic.
SSSCPreds: Deep Neural Network-Based Software for the Prediction of Conformational Variability and Application to SARS-CoV-2	Izumi,  H,  Nafie, et al	ACS Omega	Coronavirology| Coronavirologie	We report the construction of a deep neural network-based program for sequence-based prediction of supersecondary structure codes (SSSCs), called SSSCPrediction (SSSCPred). Further, to predict conformational flexibility or rigidity in proteins, a comparison program called SSSCPreds that consists of three deep neural network-based prediction systems (SSSCPred, SSSCPred100, and SSSCPred200) has also been developed. Using our algorithms we calculated here shows the degree of flexibility for the receptor-binding motif of SARS-CoV-2 spike protein and the rigidity of the unique motif (SSSC: SSSHSSHHHH) at the S2 subunit and has a value independent of the X-ray and Cryo-EM structures.
The evaluation of clinical symptoms and underlying factors in infected patients with Covid-19	Jaafarabadi,  M,  Bagheri, et al	Tehran University Medical Journal	Epidemiology| Épidémiologie Clinical data| Données cliniques	This descriptive-analytical study, conducted on 510 infected patients in the infectious disease clinic of Imam Khomeini Hospital in Tehran from March 2019 to June 2020 for A period of Four months during the first wave of Covid-19 pandemic.  The results showed that Chronic diseases such as hypertension was 4.9 times more likely (OR=4.9, 95% CI2. 433-10.25, P=0.0001) and anemia with 22 times more likely (OR=22.905, 95% CI9. 355-56.083, P=0.000) in hospitalized vs. outpatient cases of COVID.  Vitamin d3 supplementation was also significantly higher among outpatient cases.
PMC7756167; Association between COVID-19 cases and international equity indices	James,  N,  Menzies, et al	Physica D	Economics | Économie	This paper analyzes the impact of COVID-19 on the populations and equity markets of 92 countries. We compare country-by-country equity market dynamics to cumulative COVID-19 case and death counts and new case trajectories. Finally, we show there is no relationship between countries' equity market performance and their success in managing COVID-19. Each country's equity index has been unresponsive to the domestic or global state of the pandemic.
COVID-19 second wave mortality in Europe and the United States	James,  Nick,  Menzies, et al	ArXiv	Epidemiology| Épidémiologie	Epidemiology- death rates Europe/USA- this paper identifies similarities in the trajectories of cases and deaths for European countries and U.S. states. Our analysis refines the popular conception that the mortality rate has greatly decreased throughout Europe during its second wave of COVID-19; instead, we demonstrate a bifurcation in which wealthier Western European countries have managed their mortality rate more successfully. A similar distinction exists in the United States, where Northeastern states have been the most successful in the country.
Descriptive record of the activity of military critical care transfer teams deployed to London in 20 April to undertake transfer of patients with COVID-19	James,  RH,  Doyle, et al	BMJ Mil Health	Healthcare Response | Réponse des soins de santé	This was the first occasion on which the Defence Medical Services (DMS) were the main focus of a large-scale clinical military aid to the civil authorities. Following a period of training, the teams undertook 52 transfers over a 14-day period. LI centred around minimising both interruption to ventilation and risk of aerosolisation of infectious particles and thus the risk of transmission of COVID-19 to the treating clinicians. Three patient-related complications (6% of all transfers) were identified.
HLA-C* 04:01 is a Genetic Risk Allele for Severe Course of COVID-19	January,  Weiner,  Phillip, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	We analyzed a total of 332 samples.  Germany, Spain, and Switzerland USA.  We identified HLA-C* 04:01 as a novel genetic predictor for severe clinical course in COVID-19. Carriers of HLA-C* 04:01 had twice the risk of intubation when infected with SARS-CoV-2 (hazard ratio 2.1, adjusted p-value=0.0036).
GPR and ANN based Prediction Models for COVID-19 Death Cases	Jarndal,  A,  Husain, et al		Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	The Gaussian Process Regression (GPR) approach has been used to build the model and its performance was compared with a corresponding Artificial Neural Network (ANN) model. The model was applied to reliable data published by the World Health Organization (WHO) for different countries in North America, Europe and the Gulf region. The model provided impressive results with an excellent prediction of data from all the countries under investigation. The model may be useful in estimating the number of deaths due to any arbitrary number of inputs.
Remdesivir-Ivermectin combination displays synergistic interaction with improved in vitro antiviral activity against SARS-CoV-2	Jeffreys,  Laura,  Pennington, et al	bioRxiv	Therapeutics| Thérapeutique	Here, we report on the in vitro synergistic interaction between two FDA approved drugs, remdesivir (RDV) and ivermectin (IVM) resulting in enhanced antiviral activity against SARS-CoV-2, the causative pathogen of COVID-19. These findings warrant further investigations into the clinical potential of this combination, together with studies to define the underlying mechanism.
Lack of Association of Baseline 25-Hydroxyvitamin D Levels and Cholecalciferol Treatment With Disease Severity and Mortality in Indian Patients Hospitalized for Covid-19	Jevalikar,  Ganesh,  Mithal, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques	We conducted a prospective, observational study of patients, hospitalized with COVID-19. Serum 25-OHD level < 20 ng/mL was considered VDD. Patients were classified as having mild and severe disease on basis of the WHO ordinal scale for clinical improvement (OSCI). Of the 410 patients recruited, patients with VDD (197,48∙2%) were significantly younger and had lesser comorbidities. The proportion of severe cases (13∙2% vs.14∙6%), mortality (2% vs. 5∙2%), oxygen requirement (34∙5% vs.43∙4%), ICU admission (14∙7% vs.19∙8%) was not significantly different between patients with or without VDD. There was no significant correlation between serum 25-OHD levels and inflammatory markers studied. Serum parathormone levels correlated with D-dimer (r 0∙117, p- 0∙019), ferritin (r 0∙132, p-0∙010), and LDH (r 0∙124, p-0∙018).
COVID-19 in pediatric survivors of childhood cancer and hematopoietic cell transplantation from a single center in New York City	Jimenez-Kurlander,  L,  Antal, et al	Pediatr Blood Cancer	Epidemiology| Épidémiologie Clinical data| Données cliniques	We assessed COVID-19-related symptoms, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG seroprevalence, and rate of COVID-19-related hospitalization among 321 asymptomatic survivors of childhood cancer or transplantation seen for routine long-term follow-up between May and September 2020 in a New York City tertiary cancer center. While 10.9% (n = 35) reported possible COVID-19-related symptoms, 7.8% (n = 20) of those tested had positive SARS-CoV-2 IgG, and one patient (0.3%) required COVID-19-related hospitalization. This report suggests that childhood cancer survivors appear to be at relatively low risk for COVID-19 complications.
Experiences of nurses at a general hospital in Seoul which is temporarily closed due to COVID-19	Jin,  D,  Lee, et al	Journal of Korean Academic Society of Nursing Education	Healthcare Response | Réponse des soins de santé	This study was a qualitative study using individual in-depth interviews, and data were collected from 10 nurses in a university hospital temporarily closed from May 1 to June 13, 2020.  In conclusion, there is a need for education that nurtures the ability of nurses to screen patients with infectious diseases well and to skillfully wear and remove protective clothing. In addition, in order to cultivate the expertise of nurses and respond efficiently to infectious diseases, a separate compensation, such as a risk allowance, is required along with the establishment of an infrastructure that fully supports personnel and supplies. A mental health program to relieve stress is also required
Who gets the ventilator? Moral decision making regarding medical resource allocation in a pandemic	Jin,  L,  Huang, et al	Journal of the Association for Consumer Research	Public Health Priorities| Priorités de santé publique	Using over 75,000 hypothetical decisions collected from over 5,000 people across 11 countries accounting for over 69% of all COVID-19 cases reported worldwide, we explore lay people’s preferences of how scarce medical resources should be allocated in the time of the COVID-19 pandemic. Our findings suggest that people have the strongest preferences for saving young (vs. old) patients and saving patients that are more likely to survive, indicating that lay people consider maximizing total benefits as the most important ethical rule when allocating scarce medical resources in the COVID-19 pandemic.
Pityriasis rosea in otherwise asymptomatic confirmed COVID-19–positive patients: A report of 2 cases	Johansen,  M,  Chisolm, et al	JAAD Case Reports	Clinical data| Données cliniques	case reports-  2 cases of pityriasis rosea in Fitzpatrick types III and IV skin in otherwise asymptomatic COVID-19–positive patients.
Genetic epidemiology of variants associated with immune escape from global SARS-CoV-2 genomes	Jolly,  Bani,  Rophina, et al	bioRxiv	Epidemiology| Épidémiologie Coronavirology| Coronavirologie	Our analysis suggests that a number of genetic variants associated with immune escape have emerged in global populations.  To understand the genetic epidemiology of these variants in the global compendium of genomes, we compiled the dataset of 240,133 genomes from 133 countries. Only countries with at least 100 good quality genome submissions were considered for the analysis. 86 of the 120 genetic variants associated with immune escapes were found in a total of 26,917 genomes from 63 countries (Figure 1A), out of which 9 variants had >1% frequency in the respective countries
PMC7756168; Coronavirus Infections and Deaths by Poverty Status: The Effects of Social Distancing	Jung,  J,  Manley, et al	J Econ Behav Organ	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	We study the spread of COVID-19 infections and deaths by county poverty level in the US. In the beginning of the pandemic, counties with either very low poverty levels or very high poverty levels reported the highest numbers of cases. Second, we discuss the pattern of infections spreading from higher to lower income counties. Third, we show that stay-at-home mandates caused significantly higher reductions in mobility in high income counties that experienced adverse weather shocks than counties that did not. These effects are not present in counties with high poverty rates. Using weather shocks in combination with stay-at-home mandates as an instrument for social distancing, we find that measures taken to promote social distancing helped curb infections in high income counties but not in low income counties. These results have important policy implications for containing the spread of infectious diseases in the future
Genetic evolution analysis of SARS-CoV-2 ORF 1ab/S/M protein and screening of epitopes of mRNA vaccine	Kai,  C,  Chen-Xia, et al	Medical Journal of Chinese People's Liberation Army	Coronavirology| Coronavirologie	To analyze the genetic and evolutionary properties of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF 1ab/S/M proteins and select antigen epitope sequences of mRNA vaccines.  he SARS-CoV-2 ORF 1ab nucleic acid sequence similarity is 100.0%, while the homology is 99.3% in the global hot region; the S-protein nucleic acid sequence similarity is 100.0%, while the homology is 97.5%; the M-protein nucleic acid sequence similarity is 100.0%, while the homology is 99.9%. Global distribution of ORF 1ab/S/M proteins indicates that there is a significant genetic difference between the Americas and Eurasia.
Estimation of the effective reproduction number for SARS-CoV-2 infection during the first epidemic wave in the metropolitan area of Athens, Greece	Kaloudis,  Konstantinos,  Kevrekidis, et al	ArXiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	estimations for the effective reproduction number Re for the greater metropolitan area of Athens, Greece during the first wave of the pandemic (February 26-May 15, 2020). Our analysis revealed that the expected value of Re dropped below 1 around March 15, shortly after the suspension of the operation of educational institutions of all levels nationwide on March 10, and the closing of all retail activities (cafes, bars, museums, shopping centres, sports facilities and restaurants) on March 13. On May 4, the date on which the gradual relaxation of the strict lockdown commenced, the expected value of Re was slightly below 1, however with relatively high levels of uncertainty due to the limited number of notified cases during this period.
Smoking, Vaping, and Tobacco Industry during COVID-19 Pandemic: Twitter Data Analysis	Kamiński,  M,  Muth, et al	Cyberpsychology, Behavior, and Social Networking	Public Health response| Interventions de santé publique	We aimed to analyze tweets on COVID-19 and smoking coming from casual Twitter users and Twitter accounts representing the tobacco industry.  The sentiment of tweets was negative, hitting a nadir in mid-March, but became less negative in April when preprints suggesting benefits from smoking on COVID-19 were released. Similar trends were observed for the ratios of likes or retweets to followers. We found 58 messages from the tobacco industry concerning COVID-19. Twenty-two (37.9 percent) mentioned the efforts of tobacco companies to support the development of a COVID-19 vaccine. Two tweets included Food and Drug Administration statements that there is no evidence that vaping increases the risk of COVID-19.
Covid-19 infection in patients with primary immunodeficiencies	Kan,  NY,  Mukhina, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Clinical data| Données cliniques	March 1, 2020 to October 15, 2020, 15 cases of close intrafamilial contact between PIDs patients and COVID-19 patients without reliable infection of the first and 23 cases of COVID-19 infection in PIDs patients were reported.  6/23 infected people had asymptomatic course of infection, 9/23 patients – mild form, 8/23 – moderate form of disease, one patient had a severe course with a fatal outcome.
Evaluation of the relationship between perceived social support, coping strategies, anxiety, and depression symptoms among hospitalized COVID-19 patients	Kandeğer,  A,  Aydın, et al	Int J Psychiatry Med	Mental Health | santé mentale	We aimed to evaluate the relationship between perceived social support, coping strategies, anxiety, and depression symptoms among hospitalized COVID-19 patients by comparing them with a matched control group in terms of age, gender, and education level. The patient group (n = 84) and the healthy controls (HCs, n = 92) filled in the questionnaire. In logistic regression analysis performed in COVID-19 patients, the presence of chest CT finding (OR = 4.31; 95% CI = 1.04-17.95) was a risk factor for anxiety and the use of adaptive coping strategies (OR = 0.86; 95% CI = 0.73-0.99) had a negative association with anxiety. In addition, the use of adaptive coping strategies (OR = 0.89; 95% CI = 0.79-0.98) and high perceived social support (OR = 0.97; 95% CI = 0.93- 0,99) had a negative association with depression symptoms.
Favipiravir use in COVID-19: Analysis of suspected adverse drug events reported in the WHO database	Kaur,  RJ,  Charan, et al	Infection and Drug Resistance	Therapeutics| Thérapeutique	Summary of  adverse reactions reported for favipiravir. This study is based on 194 ADEs reported from 93 patients. Most frequent ADEs suspected to be caused by the favipiravir included increased hepatic enzymes, nausea and vomiting, tachycardia, and diarrhea. Severe and fatal ADEs occurred more frequently in men and those over the age of 64 years. Blood and lymphatic disorders, cardiac disorders, hepatobiliary disorders, injury poisoning, and procedural complications were more common manifestations of severe ADEs.
Prognostic factors of initial chest ct findings for icu admission and mortality in patients with covid-19 pneumonia	Kazemi,  MA,  Ghanaati, et al	Iranian Journal of Radiology	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	his retrospective study included 91 patients (34 women, and 57 men) of real-time reverse transcription polymerase chain reaction (RT-PCR) positive COVID-19 from three hospitals in Iran between February 25, 2020, to March 15, 2020. Patients were divided into two groups as good prognosis, discharged from the hospital and alive without symptoms (48 patients), and poor prognosis, died or needed ICU care (43 patients).  There was a correlation between total CT-score and prognosis and an 11.5 score was suggested as a cut-off with 67.4% sensitivity and 68.7% specificity in differentiation of poor prognosis patients (patients who needed ICU admission or died).
Modeling the flow of the COVID-19 in Germany: The efficacy of lockdowns and social behavior	Khairulbahri,  Muhamad	medRxiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	computer simulation in understanding the flow of the COVID-19 in Germany between January 2020 and July 2020. This aims to analyze not only the flow of the COVID-19 but also the efficacy of taken measures during the given period. The computer model is based on the SEIR concept and it is based on the system dynamics approach in which some uncertain parameters are estimated through the calibration process.
Comparison of Mortality Rate and Severity of Pulmonary Involvement in Coronavirus Disease-2019 Adults Patients With and Without Type 2 Diabetes: A Cohort Study	Khalili,  S,  Moradi, et al	Canadian Journal of Diabetes	Epidemiology| Épidémiologie Clinical data| Données cliniques	Canada: The mortality rate due to COVID-19 did not differ significantly between patients with or without diabetes in this cohort study, of patients with diabetes who were hospitalized due to COVID-19 during the period from February 2020 to May 2020. Over a period of 4 months, 127 patients with diabetes and 127 individuals without diabetes with a diagnosis of COVID-19 were recruited. Their mean age was 65.70±12.51 years. Mortality was higher in the group with diabetes (22.8% vs 15.0%; p=0.109), although not significantly. More severe pulmonary involvement (p=0.015), extended hospital stay (p<0.001) and greater need for invasive ventilation (p=0.029) were reported in this population. Stepwise logistic regression revealed that diabetes was not independently associated with mortality (p=0.092). Older age (odds ratio OR], 1.054; p=0.003), aggravated pulmonary involvement on admission (OR, 1.149; p=0.001), presence of comorbidities (OR, 1.290; p=0.020) and hypothyroidism (OR, 6.576; p=0.021) were associated with mortality. Diabetic foot infection had a strong positive correlation with mortality (OR, 49.819; p=0.016), whereas insulin therapy had a negative correlation (OR, 0.242; p=0.045).
PMC7746142; The Persian COVID stress scales (Persian-CSS) and COVID-19-related stress reactions in patients with obsessive-compulsive and anxiety disorders	Khosravani,  V,  Asmundson, et al	J Obsessive Compuls Relat Disord	Mental Health | santé mentale Public Health response| Interventions de santé publique	this study sought to validate the Persian CSS (Persian-CSS) and to compare COVID-19-related stress reactions among patients with specific ADs and OCD. Patients with OCD (n = 300) and ADs (n = 310) completed the Persian-CSS and other scales developed to assess anxiety-related traits and COVID-19-related distress.  Patients with panic disorder had higher danger and contamination fears and xenophobia than patients with OCD. The study suggests that the Persian-CSS is a valid scale to be used in patients with OCD and ADs, each of whom differs in their specific patterns of COVID-19-related stress reactions.
S-variant SARS-CoV-2 is associated with significantly higher viral loads in samples tested by ThermoFisher TaqPath RT-QPCR	Kidd,  Michael,  Richter, et al	medRxiv	Epidemiology| Épidémiologie Coronavirology| Coronavirologie	UK- analysis of new variant "S-dropout" samples from Birmingham University Turnkey laboratory is part of the Lighthouse network responsible for testing clinical samples under the UK government ‘Test & Trace’ scheme. Based on our Qnostics EQA verification data for the TaqPath test (table 2), a Ct value of approximately 15-16 corresponds to a viral load of 1 x 10^6 copies per millilitre (mL). Therefore, our observed cluster of S-dropout samples at Ct less than 15 corresponds to a conservative estimate of a significantly larger population of infectious subjects that have an increased viral load up to 10,000-fold higher. Such capability of increased transmission has been ascribed to an S ‘variant of concern’ apparently spreading throughout the South-east of the UK, and possibly beyond; but epidemiologically it is difficult to disentangle other reasons for more efficient spread, such as human behavioural factors, from those of a clinical virological nature.
Financial Hardship and Social Assistance as Determinants of Mental Health and Food and Housing Insecurity During the COVID-19 Pandemic	Kim,  Daniel	medRxiv	Mental Health | santé mentale Public Health response| Interventions de santé publique	USA Using multivariable logistic regression and pooled repeated cross-sectional individual-level data on working-aged adults from nationally-representative surveys administered from September to November 2020, this study investigated the relationships between financial hardship and depressive and anxiety symptoms, food insufficiency, and, among housing renters, the likelihood of being evicted, controlling for the receipt of social assistance and other demographic and socioeconomic factors. Experiencing somewhat of a financial hardship (vs no hardship) was linked to approximately 3-4 times higher odds of depressive or anxiety symptoms and a likely eviction, and a 15 times higher odds of food insufficiency. Experiencing considerable financial hardship (vs no hardship) predicted a 6-fold higher odds of depressive or anxiety symptoms, a 24-fold higher odds of a likely eviction, and a more than 50-fold higher odds of food insufficiency (all P values <.001).
Influence of quarantine mask use on skin characteristics: One of the changes in our life caused by the COVID-19 pandemic	Kim,  J,  Yoo, et al	Skin Res Technol	Public health interventions*| Interventions de sant&amp;eacute; publique	quarantine masks impact on skin properties, 20 people, 6 hours per day for 2 weeks:  Skin temperature, redness, and TEWL increased significantly after a 6-hour mask use, while the sebum content increased marginally. Skin elasticity was reduced by the use of masks over 1 and 2 weeks, whereas the pore volume and the number of acne lesions increased after a 2-week mask use. The skin changes caused by mask use showed sex-based differences in the skin elasticity (after 6 hours), redness, and roughness (after 2 weeks).
Improvement of COVID-19 with renal failure and paralytic ileus by using steroids	Kitamura,  A,  So, et al	Respirology Case Reports	Clinical data| Données cliniques	case report:  His clinical course included respiratory failure, acute kidney injury, and paralytic ileus. Systemic management was difficult, but he recovered with high-dose steroids, temporary haemodialysis therapy, and a nasointestinal tube, without antiviral drugs. COVID-19 can be associated with multiple organ failure due to vascular endothelial injury.
Coronavirus Disease 2019 Infection in a Child with Mild Symptoms and Atypical Course	Koç,  E,  Ylldlrlm, et al	Journal of Pediatric Infectious Diseases	Clinical data| Données cliniques	case report: a 25-month-old girl patient without any symptom besides high fever and who had no risk factor or suspicious contact. Also, she developed maculopapular rash that is not reported before in the COVID-19 patients to the best of our knowledge.
Shortening turnaround time for highpriority patients during the covid-19 epidemic: Evaluation of the xpert xpress sars-cov-2 test	Kogoj,  R,  Rus, et al	Zdravniski Vestnik	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	evaluate the performance and possible benefits of the Cepheid Xpert Xpress SARS-CoV-2 test, focusing mainly on turnaround time when applied to high-priority patients  in comparison to the Roche’s cobas 6800 SARS-CoV-2 test by monitoring turnaround times and by retrospectively testing 20 nasopharyngeal swabs from COVID-19 patients with various viral loads. We observed a lower limit of detection of one SARS-CoV-2 genome equivalent/µL and 100% (95% CI, 92.6−100%) specificity and 95.5% (95% CI, 77.2−99.9%) sensitivity in comparison to the cobas SARS-CoV-2 test. When applying the Xpert Xpress SARS-CoV-2 test for high-priority patients the turnaround time could be greatly reduced, i.e. from 3-5 hours that take our routine diagnostics methods to about 1 hour.
A Rare Case of Hairy Cell Leukemia with Unusual Loss of CD123 Associated with COVID-19 at the Time of Presentation	Kohla,  S,  Ibrahim, et al	Case Reports in Oncology	Clinical data| Données cliniques	case report:  a unique case of a COVID-19-positive male who presented with severe respiratory symptoms, deteriorated quickly, and was intubated. Workup of severe progressive pancytopenia and bone marrow examination revealed HCL without splenomegaly and with atypical unusual loss of CD123. To our knowledge, this is the first case of CD123-negative HCL without splenomegaly associated with COVID-19 infection as the initial presentation
Serum ACE as a prognostic biomarker in COVID-19: A case series	Kolberg,  ES,  Wickstrøm, et al	Apmis	Clinical data| Données cliniques	Prospective case series to investigate the potential of s-ACE as a prognostic biomarker in COVID-19. S-ACE was analyzed in serum for 15 symptomatic patients admitted to Oslo University Hospital (OUH), Norway, No relationship was seen between serum ACE (s-ACE) , a potential biomarker for severity and severity in COVID-19.
Coronavirus infection (Covid-19) in children with cystic fibrosis	Kondratyeva,  EI,  Sherman, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Epidemiology| Épidémiologie Clinical data| Données cliniques	Russian: Objective of the research: to assess the prevalence and course of COVID-19 in children and adolescents with cystic fibrosis (CF) in the Russian Federation. Materials and methods: up to September 1, 2020, 10 cases of COVID-19 in CF patients were registered. Results: the incidence of COVID-19 among children and adolescents with CF up to September 1, 2020 was 3,4:1000. Asymptomatic course was noted in 3 children, mild – in 5, moderate – in 2 (20%) with pneumonia. The main symptoms were fiver (60% – 6 children), increased cough – 5 (50%) and fatigue – in 3 children (30%), in 2 patients (20%) abdominal syndrome. All patients received dornase alfa inhalations, two patients received azythromycin for anti-inflammatory purposes and permanent antibacterial therapy. These factors may play a role in the milder course of COVID-19 in children and adolescents with CF.
SARS-CoV-2 mutations among minks show reduced lethality and infectivity to humans	Konishi,  Tomokazu	bioRxiv	Epidemiology| Épidémiologie Coronavirology| Coronavirologie	Netherlands,  analysis of mink strain SARS-CoV-2 compared to human-variants.  Up to 40% of the cases in the Netherlands were from mink-derived variants, which appear to be less lethal and infective compared to human variants.  Variants from mink that mutated further were not identified in humans.
Comparison of daily reproduction of COVID-19 among countries by a new reproduction index RW8	Kotani,  T,  Sawada, et al	Journal of the Physical Society of Japan	Modelling/ prediction| Modélisation/prédiction	We have developed a new and simple reproduction index RW8(i) for COVID-19. RW8(i) can be directly calculated from the numbers of newly confirmed cases daily. Although RW8(i) has a limitation as discussed in Sect. 2, RW8(i) as well as RW8,W(i) should be useful for monitoring the real-time situation of the spred of COVID-19. With RW8(i), we compared status of infections of COVID-19 among various countries on an equal footing.
Increased prevalence of face mask—induced itch in health care workers	Krajewski,  PK,  Matusiak, et al	Biology	Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)	face-mask-associated itch. Health care workers (HCW) wear masks for prolonged periods and are prone to adverse effects.  A total of 1156 HCW completed the survey. Among them, 31.6% (365) reported suffering from itch associated with face mask use.
Peculiarities of covid-19 in children of different age groups	Krasnova,  EI,  Karpovich, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Epidemiology| Épidémiologie Clinical data| Données cliniques	In Russian, could not locate.  pilot open observational prospective study of 218 pediatric patients with laboratory-verified COVID-19 diagnosis was performed. The development of COVID-19 pneumonia was recorded in 11,5% of cases (25 patients), while more often pneumonia was recorded in children of the first year of life, as well as over 12 years of age (23,5% and 20% of cases, respectively) than in children of other age groups (p<0,05). CT-1 stage was recorded in 13 patients (52% of cases), CT-2 stage in 10 patients (40% of cases), CT-3 stage in 2 patients (8% of cases). The leading clinical symptoms of COVID-19 in children were: hyperemia of the mucous membranes of the pharynx – 100% of cases (218 patients); increased body temperature – 95,9% of cases (209 patients), while the average figures were 37,6 (36,6; 38,2)0 С; cough – 19,7% of cases (43 patients, of which 21 with pneumonia); diarrhea – 17,9% of cases (39 patients); vomiting – 6,4% of cases (14 patients); change in the auscultatory picture – 3,7% of cases (8 patients with pneumonia). In infants with COVID-19, diarrhea was more often recorded in comparison with patients in the age group over 13 years old (35% and 4% of cases, respectively; p=0,001). The development of cough was less often recorded in children of the first year of life, in Compared with patients over 13 years of age (9% and 40% of cases, respectively; p=0,004), the same trend was observed in COVID-19 pneumonia (25% and 89% of cases, respectively, p=0,02).
Surveillance of acute SARS-CoV-2 infections in school children and point-prevalence during a time of high community transmission in Switzerland	Kriemler,  Susi,  Ulyte, et al	medRxiv	Epidemiology| Épidémiologie	Switzerland December 2020- infection prevalence in schools: 14 out of the randomly selected sample of the Ciao Corona cohort study participated between December 1 and 11, a time when incidence rate for SARS-CoV-2 infections was high for the canton of Zurich. We determined point-prevalence of acute SARS-CoV-2 infections of school children attending primary and secondary school. A buccal swab for polymerase chain reaction (PCR) and a rapid diagnostic test (RDT) to detect SARS-CoV-2 were taken twice 1 week apart (T1 and T2) in a cohort of children from randomly selected classes. A questionnaire assessed demographics and symptoms compatible with a SARS-CoV-2 infection during the past 5 days.Results Out of 1299 invited children, 641 (49%) 6- to 16-year-old children and 66 teachers from 14 schools and 67 classes participated in at least 1 of 2 testings. None of the teachers but 1 child had a positive PCR at T1, corresponding to a point-prevalence in children of 0.2% (95% CI 0.0% to 1.1%), and no positive PCR was detected at T2. The child with positive PCR at T1 was negative on the RDT at T1 and both tests were negative at T2. There were 7 (0.6%) false positive RDTs in children and 2 (1.7%) false positive RDTs in teachers at T1 or T2 among 5 schools (overall prevalence 0.7%). All 9 initially positive RDTs were negative in a new buccal sample taken 2 hours to 2 days later, also confirmed by PCR. 35% of children and 8% of teachers reported mild symptoms during the 5 days prior to testing.
Identification of Mutation Resistance Coldspots for Targeting the SARS-CoV2 Main Protease	Krishnamoorthy,  Navaneethakrishnan,  Fakhro, et al	Research Square prepub	Coronavirology| Coronavirologie	Identified 24 mutational “coldspots” that have resisted mutation since the virus was first detected. We compared the structure-function relationship of these coldspots with several SARS-CoV2 Mpro X-ray crystal structures. We found that three coldspot residues (Leu141, Phe185 and Gln192) help to form the active site, while six (Gly2, Arg4, Tyr126, Lys137, Leu141 and Leu286) contribute to dimer formation that is required for Mpro activity. The surface of the dimer interface is more resistant to mutations compared to the active site. Interestingly, 16 coldspots are found in conserved patterns when compared with other coronaviruses.
Prediction of the transition from subexponential to the exponential transmission of SARS-CoV-2 in Chennai, India: Epidemic nowcasting	Krishnamurthy,  K,  Ambikapathy, et al	JMIR Public Health and Surveillance	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	Analyze the transition of the epidemic from subexponential to exponential transmission in the Chennai metro zone and to analyze the probability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) secondary infections while availing the public transport systems in the city.  The model predicted that transition from subexponential to exponential transmission occurs around the eighth week after the reporting of a cluster of cases. The probability of secondary infections with a single index case in an enclosure of the city bus, the suburban train general coach, and the ladies coach was found to be 0.192, 0.074, and 0.114, respectively.
Assessing the strength of case growth trends in the coronavirus pandemic: Assessing epidemic growth strength	Kriston,  L	Royal Society Open Science	Modelling/ prediction| Modélisation/prédiction	Predictive modeling tools: The trend strength indicators provided information that was not clearly recognizable from the daily new case counts and their MA. First, they helped to confirm trends that otherwise were identified only by visual inspection of the MA. For instance, the continuously growing number of daily new infections in India was unequivocally categorized as a highly probable wave since the beginning of April. Second, they were able to identify trend-free periods, like the weeks between the middle of June and the middle of July 2020 in Germany. Third, they frequently indicated epidemic transitions before they became clearly visible in the MA of case counts, making them potential candidates for early warning signals of change
Mathematical Modeling and Forecasting of COVID-19 in Moscow and Novosibirsk Region	Krivorot’ko,  OI,  Kabanikhin, et al	Numerical Analysis and Applications	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	Prognostic scenarios for COVID-19 spread in Moscow and in Novosibirsk region are developed, and the applicability of the models is analyzed.  Simulation and forecast of the development of coronavirus infection in Novosibirsk region were made for two sets of measurements: from 23.03.2020 to 31.05.2020 and up to 15.06.2020, due to the scarce statistics up to April 15, 2020. It has been shown that no epidemic peak has yet been reached. For the above measurement intervals, SEIR-D provides the most accurate simulation results for the coronavirus infection spread in Novosibirsk region.
Repurposing Screens of FDA-Approved Drugs Identify 29 Inhibitors of SARS-CoV-2	Ku,  KB,  Shin, et al	J Microbiol Biotechnol	Therapeutics| Thérapeutique	In this work, we screened 1,473 FDA-approved drugs to identify inhibitors of SARS-CoV-2 infection using cell-based assays. The antiviral activity of each compound was measured based on the immunofluorescent staining of infected cells using anti-dsRNA antibody. Twenty-nine drugs among those tested showed antiviral activity against SARS-CoV-2. We report this new list of inhibitors to quickly provide basic information for consideration in developing potential therapie
Therapeutic Approach Against 2019-nCoV by Inhibition of the ACE-2 receptor	Kumar,  G,  Kumar, et al	Drug Res (Stuttg)	Therapeutics| Thérapeutique	Behind paywall.  Maybe a review. Our aim in presenting this article is to provide an easy therapeutic approach that effectively combats deadly viral diseases, such as COVID-19, with minimal intervention and effort. Different Ayurvedic therapeutic agents (Curcuma longa L, green tea, and Piper nigrum) inhibit the entry of viruses in the host cell and the transmission of pathogens, while improving immunity. Curcumin and piperine (1-piperoylpiperidine) interact with each other and form a π–π intermolecular complex that enhances the bioavailability of curcumin by inhibition of glucuronidation of curcumin in the liver. Two molecules, curcumin and catechin, bind directly to the receptor-binding domain of the S-protein and the angiotensin-converting enzyme 2 receptor of the host cell, by which these molecules inhibit the entry of viruses in the host cell. As a result, the animal host will survive the infection.
Stillbirths and the COVID-19 pandemic: Looking beyond SARS-CoV-2 infection	Kumar,  M,  Puri, et al	Int J Gynaecol Obstet	Healthcare Response | Réponse des soins de santé	Pandemic impact on pregnancy and still-births in India  (not related to COVID-19 infection):  case-control study was performed comparing stillbirths from March to September 2020 (cases) and March to September 2019 (controls) in a tertiary care center in India.  A significant difference in the rate of stillbirths was found among cases (37.4/1000) and controls (29.9/1000) (P=0.045). Abruption in normotensive women was significantly higher in cases compared to controls (P=0.03). Modifiable factors or preventable causes were noted in 76.1% of cases and 59.6% of controls; the difference was highly significant (P<0.001, relative risk RR] 1.8). Level-II delays or delays in reaching the hospital for delivery due to lack of transport were observed in 12.7% of cases compared to none in controls (P<0.006, RR 47.7). Level-III delays or delays in providing care at the facility were observed in 31.3% of cases and 11.5% of controls (P<0.001, RR 2.7).
Burns and COVID-19 - Initial Experience and Challenges	Kumar,  S,  Kain, et al	J Burn Care Res	Healthcare Response | Réponse des soins de santé	Burn unit challenges with COVID-19 case management: We have described the various challenges we faced in managing burns during this time. We found that effective screening of patients and healthcare workers, proper segregation of negative and positive/ suspect population and a low threshold for COVID-19 testing were essential to mitigate transmission of infection.
Differential Dynamic Behavior of Prefusion Spike Proteins of SARS Coronaviruses 1 and 2	Kumar,  Vivek Govind,  Ogden, et al	bioRxiv	Coronavirology| Coronavirologie	cryogenic electron microscopy (cryo-EM) studies show that ACE2 binding is preceded by a large-scale conformational change in the spike protein to expose the receptor binding domain (RBD) to its binding partner. Unfortunately, these studies do not provide detailed information on the dynamics of this activation process. Here, we have used an extensive set of unbiased and biased microsecond-timescale all-atom molecular dynamics (MD) simulations of SARS-CoV-1 and SARS-CoV-2 spike protein ectodomains in explicit solvent to determine the differential behavior of spike protein activation in the two viruses. Based on the results, we hypothesize that the greater propensity of the SARS-CoV-2 spike protein to remain in the active conformation contributes to the higher transmissibility of SARS-CoV-2 in comparison to SARS-CoV-1.
Dual inhibition of SARS-CoV-2 spike and main protease through a repurposed drug, rutin	Kumari,  A,  Rajput, et al	J Biomol Struct Dyn	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Rutin:  two drug targets, namely the spike protein and main protease, belonging to structural and non-structural class of proteins respectively, were utilized to carry out drug repurposing based screening.  Further, molecular dynamics simulations in explicit solvent affirmed the stable and sturdy binding of rutin with these proteins. The decreased R(g) value (4 nm for spike-rutin and 2.23 nm for main protease-rutin) and stagnant SASA analysis (485 nm/S(2)/N in spike-rutin and 152 nm/S2/N in main protease-rutin) for protein surface and its orientation in the exposed and buried regions suggests a strong binding interaction of the drug. Further, cluster analysis and secondary structure analysis of complex trajectories validated the conformational changes due to binding of rutin.
Influenza vaccine uptake, COVID-19 vaccination intention and vaccine hesitancy among nurses: A survey	Kwok,  KO,  Li, et al	International journal of nursing studies	Vaccine Research| Recherche sur les vaccins Healthcare Response | Réponse des soins de santé	Vaccine Intention Survey: Hong Kong, 1205 nurses cross sectional survey,  mid-March and late April 2020. The influenza vaccine uptake rate and the proportion intending to take COVID-19 vaccine were 49% and 63%, respectively.   stronger COVID-19 vaccination intention was associated with younger age, more confidence, less complacency and more collective responsibility. COVID-19-related demands were associated with greater work stress, and hence stronger COVID-19 vaccination intention.
Detecting the patient's need for help with machine learning	Lahti,  Lauri	ArXiv	Public Health response| Interventions de santé publique	Online respondents between 30 May and 3 August 2020 were recruited from Finnish patient and disabled people's organizations, other health-related organizations and professionals, and educational institutions (n=673).  We analyzed self-rated expression statements concerning the coronavirus COVID-19 epidemic
What influences the infection of COVID-19 in healthcare workers?	Lai,  X,  Zhou, et al	Journal of infection in developing countries	Epidemiology| Épidémiologie Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)	The study was performed among COVID-19 infected and uninfected healthcare workers in three hospitals in Wuhan. A total of 325 healthcare workers participated. When performing general operations on confirmed or suspected patients, the use of protective equipment including the effectiveness of masks (p < 0.001), gloves (p < 0.001); and the use of gloves (p < 0.001), suits (p < 0.001), gowns (p < 0.001), shoe covers (p < 0.001), and hats (p < 0.001) were protective factors. The use of protective equipment was a protective factor in most cases. Negative emotions and dissatisfaction to the hospital response were associated with the increased risk of infection.
Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity	Larsen,  MD,  de Graaf, et al	Science	Immunology | Immunologie	Afucosylated IgG (~6% of total IgG in humans) are specifically formed against enveloped viruses but generally not against other antigens. This mediates stronger FcγRIIIa responses, but also amplifies brewing cytokine storms and immune-mediated pathologies. Critically ill COVID-19 patients, but not those with mild symptoms, had high levels of afucosylated IgG antibodies against SARS-CoV-2, amplifying pro-inflammatory cytokine release and acute phase responses. Thus, antibody glycosylation plays a critical role in immune responses to enveloped viruses, including COVID-19.
Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2	Larue,  RC,  Xing, et al	Bioconjug Chem	Therapeutics| Thérapeutique	In vitro: designed a panel of ACE2-derived peptides based on the RBD-ACE2 binding interfaces of SARS-CoV-2 and SARS-CoV.  We identified two peptides that bound Spike RBD in affinity precipitation assays and inhibited infection with genuine SARS-CoV-2. Moreover, these peptides inhibited the replication of a common cold causing coronavirus, which also uses ACE2 as its entry receptor. Results from the infection experiments and modeling of the peptides with Spike RBD identified a 6-amino-acid (Glu37-Gln42) ACE2 motif that is important for SARS-CoV-2 inhibition.
Working condition and health status of 6,317 front line public health workers during the COVID-19 epidemic across 5 provinces in China: a cross-sectional study	Li,  Jinghua,  Xu, et al	Research Square prepub	Mental Health | santé mentale Healthcare Response | Réponse des soins de santé	China, Public Health worker- health: Investigate the working conditions and health status of frontline public health workers in China during the epidemic. Methods: Between February 18 to March 1, 2020, we conducted a cross-sectional survey among 2,313 CDC workers and 4,004 PHI workers in five provinces across China experiencing different scales of COVID-19 epidemic. The prevalence of depression, anxiety, and poor self-rated health was 21.3%, 19.0%, and 9.8%, respectively, among public health workers (27.1%, 20.6% and 15.0% among CDC workers; and 17.5%, 17.9% and 6.8% among PHI workers). The majority (71.6%) participated in both field and non-field work and gave immense efforts. Nearly 20.0% have worked all night for more than 3 days and 45.3% had worked during the whole period of Chinese New Year. Three risk factors and two protective factors were found independently associated with all three health outcomes in our final multivariate models, including working all night for >3 days (ORm=1.67~1.75, p<0.001), concerns about being infected at work (ORm=1.46~1.89, p<0.001), perceived troubles at work (ORm=1.10~1.28, p<0.001), starting COVID-19 prevention work after January 23 (ORm=0.78~0.82, p=0.002~0.008), and capability to persist for more than 1 month at the current work intensity (ORm=0.44~0.55, p<0.001).
Clinical Characteristics and Short-Term Outcomes of Acute Kidney Injury Missed Diagnosis in Older Patients with Severe COVID-19 in Intensive Care Unit	Li,  Q,  Hu, et al	Journal of Nutrition, Health and Aging	Epidemiology| Épidémiologie Clinical data| Données cliniques	Patients with severe or critical COVID-19 are at higher risk for developing acute kidney injury (AKI).This cohort study was conducted from February 4, 2020 to April 16, 2020 in Wuhan, China.  Overall, 48 of 107 patients (44.9%) developed AKI during hospitalization. Meanwhile, 22 (45.8%) cases with AKI was not recognized (missed diagnosis) in this cohort.   According to the multivariate regression analysis, the independent risk factors for in-hospital mortality were AKI (recognized AKI vs non-AKI: HR = 2.413; 95% CI = 1.092–5.333; P = 0.030 and unrecognized AKI vs non-AKI: HR = 4.590; 95% CI = 2.070–10.175; P <0.001), C-reactive protein level (HR = 1.004; 95% CI = 1.000–1.008; P = 0.030), lactate level (HR = 1.236; 95% CI = 1.098–1.391; P < 0.001), and disease classification (critical vs severe: HR = 0.019; 95% CI = 1.347–26.396; P = 5.963).
Dynamics of cytokines and lymphocyte subsets associated with the poor prognosis of severe COVID-19	Li,  Q,  Xu, et al	European review for medical and pharmacological sciences	Clinical data| Données cliniques	The lymphocyte subsets and cytokines of 31 patients with severe COVID-19 (7 deaths and 24 survivals) were longitudinally analyzed. The mean age of enrolled patients was 64 years, 24 (77.4%) patients were men, and 23 (74.2%) patients had comorbidities. Compared with survival group, the death group showed significant and sustained increases in the levels of IL-6, IL-8, and IL-10 from baseline to 28 days after admission (all p0.05). The absolute counts of CD3+ T cells, CD4+ T cells, CD8+ T cells, and CD45+ T cells were lower in both survival group and death group patients from hospital admission to 3 days after admission, and gradually recovered in 4 to 35 days in the survival group, but continually stayed at low levels in the death group during the follow-up.
[Differential diagnosis of high altitude pulmonary edema and COVID-19 with computed tomography feature]	Li,  W,  Li, et al	Sheng Wu Yi Xue Gong Cheng Xue Za Zhi	Clinical data| Données cliniques	In Chinese: Analysis of CT images for  high altitude pulmonary edema (HAPE) vs. COVID-19.  In summary, some cloudy shadows are the feature of HAPE CT image, and "crazy paving pattern" and "pleural parallel sign" belong to the COVID-19 CT, which can be used for differential diagnosis.
Development of SARS-CoV-2 isothermal amplification detection kits	Li,  X,  Tian, et al	Nano Biomedicine and Engineering	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The SARS-CoV-2 isothermal amplification detection kits based on loop-mediated isothermal amplification (LAMP) were developed and evaluated on three types samples of SARS-CoV-2. The kits included enzyme reaction mixtures and chromogenic agents. After the isothermal amplification reactions were completed, the reaction results were judged by using the chromogenic agents to determine whether SARS-CoV-2 exists in the samples to be tested. The detection kits have the advantages of convenient operation, fast detection speed and high sensitivity up to 1 copy of virus particles per reaction, which can speed up the detection speed of suspected cases, and avoid the missing detection problems caused by the low detection sensitivity
Higher Survival Rate Associated with Thymosin Alpha 1 use in Critical COVID-19: A Retrospective Multicenter Cohort Study	Li,  Yichen,  Li, et al	Research Square prepub	Therapeutics| Thérapeutique	retrospective study aimed to determine the therapeutic effect of thymosin alpha1 in critical COVID-19. Results We enrolled 109 critically ill severe acute respiratory syndrome-related coronavirus-2 RNA positive patients from 15 hospitals. The mortality rate in critical patients treated with thymosin alpha1 was 11%, compared to 56% in critical patients not treated with thymosin alpha1. With confounding factors adjusted in multivariate logistic regression, thymosin alpha1 treatment was identified as a protective factor for critical COVID-19.
A case report of a patient with severe type of coronavirus disease 2019 (Covid-19) treated by hyperbaric oxygen: Ct dynamic changes	Liang,  Y,  Fan, et al	Iranian Journal of Radiology	Clinical data| Données cliniques	Case report:  Hypoxemia is a common clinical manifestation of severe patients, and oxygen therapy is the main treatment. This article reports for the first time the computed tomography (CT) imaging dynamic changes in a case of 69-year-old male with severe type of COVID-19 treated by hyperbaric oxygen, which provides a more effective regimen for severe COVID-19 patients with hypoxemia.
Statistical power in COVID-19 case-control host genomic study design	Lin,  YC,  Brooks, et al	Genome Med	Epidemiology| Épidémiologie	infectious disease genetic epidemiology: The identification of genetic variation that directly impacts infection susceptibility to SARS-CoV-2 and disease severity of COVID-19 is an important step towards risk stratification, personalized treatment plans, therapeutic, and vaccine development and deployment. Given the importance of study design in infectious disease genetic epidemiology, we use simulation and draw on current estimates of exposure, infectivity, and test accuracy of COVID-19 to demonstrate the feasibility of detecting host genetic factors associated with susceptibility and severity in published COVID-19 study designs. We demonstrate that limited phenotypic data and exposure/infection information in the early stages of the pandemic significantly impact the ability to detect most genetic variants with moderate effect sizes, especially when studying susceptibility to SARS-CoV-2 infection. Our insights can aid in the interpretation of genetic findings emerging in the literature and guide the design of future host genetic studies.
Human Leukocyte Antigen Complex and Other Immunogenetic and Clinical Factors Influence Susceptibility or Protection to SARS-CoV-2 Infection and Severity of the Disease Course. The Sardinian Experience	Littera,  R,  Campagna, et al	Frontiers in Immunology	Epidemiology| Épidémiologie Clinical data| Données cliniques	Italy, Sardinia: recruited 619 healthy Sardinian controls and 182 SARS-CoV-2 patients. Thirty-nine patients required hospital care and 143 were without symptoms, pauci-symptomatic or with mild disease. Compared to the group of asymptomatic or pauci-symptomatic patients, hospitalized patients also had a higher frequency of autoimmune diseases and glucose-6-phosphate-dehydrogenase (G6PDH) deficiency. None of these patients carried the beta-thalassemia trait, a relatively common finding in the Sardinian population. The extended haplotype HLA-A*02:05, B*58:01, C*07:01, DRB1*03:01 OR 0.1 (95% CI 0–0.6), Pc = 0.015] was absent in all 182 patients, while the HLA-C*04:01 allele and the three-loci haplotype HLA-A*30:02, B*14:02, C*08:02 OR 3.8 (95% CI 1.8–8.1), Pc = 0.025] were more frequently represented in patients than controls. In a comparison between in-patients and home care patients, the HLA-DRB1*08:01 allele was exclusively present in the hospitalized patients OR > 2.5 (95% CI 2.7–220.6), Pc = 0.024].
Age-stratified analysis of SARS-CoV-2 infection and case fatality rate in China, Italy, and South Korea	Liu,  JQ,  Xu, et al	European review for medical and pharmacological sciences	Epidemiology| Épidémiologie	Detailed national epidemiological information of COVID-19 was retracted from the latest statistics reports from China, Italy, and South Korea.  Most deaths occurred among elderly individuals who were older than 60 years in both Italy (98.0%) and South Korea (87.9%), consistent with the previous data from China (81.0%).
Ambient air pollutants and their effect on COVID-19 mortality in the United States of America	Liu,  S,  Li, et al	Revista Panamericana de Salud Publica/Pan American Journal of Public Health	Epidemiology| Épidémiologie	Ecological study:  the impact of four ambient air pollutants on the COVID-19 mortality rate in the United States of America.   county-level mortality rates were regressed on concentration values of ground-level ozone, nitrogen dioxide, carbon monoxide, and sulfur dioxide. Four confounder variables were included in the regression analysis: median household income, rate of hospital beds, population density, and days since first confirmed case. Regression analysis showed that ground-level ozone is positively correlated with county-level mortality rates regardless of whether confounders are controlled for. Nitrogen dioxide is also shown to have a direct relationship with county-level mortality rates, except when all confounders are included in the analysis.
Differential impact of non-pharmaceutical public health interventions on COVID-19 epidemics in the United States	Liu,  Xiaoshuang,  Xu, et al	Research Square prepub	Public health interventions*| Interventions de sant&amp;eacute; publique	Based on the reported cases, the effective reproduction number (B) of COVID-19 epidemic for 50 states in the US was estimated. Measurements on the effectiveness of nine different NPIs were conducted by assessing risk ratios (RRs) between a and NPIs through a generalized linear model (GLM). Results: Different NPIs were found to have led to different levels of reduction in c. Stay-at-home contributed approximately 51% (95% CI 46%-57%), wearing (face) masks 29% (15%-42%), gathering ban (more than 10 people) 19% (14%-24%), non-essential business closure 16% (10%-21%), declaration of emergency 13% (8%-17%), interstate travel restriction 11% (5%-16%), school closure 10% (7%-14%), initial business closure 10% (6%-14%), and gathering ban (more than 50 people) 7% (2%-11%).
Cell-type apoptosis in lung during SARS-CoV-2 infection	Liu,  Yakun,  Garron, et al	bioRxiv	Clinical data| Données cliniques	he pathologic alteration known as diffuse alveolar damage in endothelial and epithelial cells is a critical feature of acute lung injury in ARDS. However, the pathogenesis of ARDS following SARS-CoV-2 infection remains largely unknown. we examined apoptosis in post-mortem lung sections from COVID-19 patients and lung tissues from a non-human primate model of SARS-CoV-2 infection, in a cell-type manner, including type 1 and 2 alveolar cells and vascular endothelial cells (ECs), macrophages, and T cells.  we observed that SARS-CoV-2 fails to induce apoptosis in human bronchial epithelial cells (i.e., BEAS2B cells) and primary human umbilical vein endothelial cells (HUVECs), which are refractory to SARS-CoV-2 infection. However, infection of co-cultured Vero cells and HUVECs or Vero cells and BEAS2B cells with SARS-CoV-2 induced apoptosis in both Vero cells and HUVECs/BEAS2B cells, but did not alter the permissiveness of HUVECs or BEAS2B cells to the virus.
Mechanical ventilation affects respiratory microbiome of COVID-19 patients and its interactions with the host	Lloréns-Rico,  Verónica,  Gregory, et al	medRxiv	Clinical data| Données cliniques	we examine potential confounders in COVID-19 microbiome studies by analyzing the upper (n=58) and lower (n=35) respiratory tract microbiome in well-phenotyped COVID-19 patients and controls combining microbiome sequencing, viral load determination, and immunoprofiling. We found that time in the intensive care unit and the type of oxygen support explained the most variation within the upper respiratory tract microbiome, dwarfing (non-significant) effects from viral load, disease severity, and immune status.
Understanding Covid-19 misinformation and vaccine hesitancy in context: Findings from a qualitative study involving citizens in Bradford, UK	Lockyer,  Bridget,  Islam, et al	medRxiv	Vaccine Research| Recherche sur les vaccins Public Health response| Interventions de santé publique	Qualitative study, UK, vaccine hesitancy:  In-depth phone interviews were carried out with 20 people from different ethnic groups and areas of Bradford during Autumn 2020.  articipants spoke about a wide range of emotive misinformation they had encountered regarding Covid-19, resulting in confusion, distress and mistrust. Vaccine hesitancy could be attributed to three prominent factors: safety concerns, negative stories and personal knowledge. The more confused, distressed and mistrusting participants felt about their social worlds during the pandemic, the less positive they were about a vaccine.
The Italian National Survey on COVID-19 epidemic spread in Nursing Homes	Lombardo,  FL,  Bacigalupo, et al	Int J Geriatr Psychiatry	Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé	Nursing Homes/ long-term care Italy: national survey was carried out to collect information on the spreading and impact of SARS-CoV-2 infection in nursing homes, and on how suspected and/or confirmed cases were managed: between March 25, 2020, and May 5, 2020.  1356 nursing homes voluntarily participated to the survey, hosting a total of 100,806 residents. Overall, 9154 residents died due to any cause from February 1 to the time when the questionnaire was completed (March 25 to May 5). Of these, 7.4% had COVID-19 and 33.8% had flu-like symptoms, corresponding to a cumulative incidence of 0.7 and 3.1, respectively. Lack of personnel, difficulty in transferring patients to hospital or other facility, isolating residents with COVID-19, number of beds and geographical area were the main factor positively associated to the presence of COVID-19 in nursing homes.
Levels and predictors of depression, anxiety, and suicidal risk during COVID-19 pandemic in Argentina: the impacts of quarantine extensions on mental health state	López Steinmetz,  LC,  Dutto Florio, et al	Psychol Health Med	Mental Health | santé mentale	Argentina, cross-sectional design with a convenience sample including 1100 participants.  Depression revealed a worsening pattern as quarantine sub-periods went by. Anxiety (both state and trait), just like suicidal risk, partially follow such a pattern, with mean scores increasing from the first to the second/third quarantine extensions, but then maintaining to the fourth extension. Predictors having protective effects on almost all the MHS indicators were: availability of current economic income (except for state-anxiety, without significant effect) and absence of suicide attempt history. Conversely, sex (woman), younger age, and mental disorder history had an increasing risk effect on all the MHS indicators.
Source Trust and COVID-19 Information Sharing: The Mediating Roles of Emotions and Beliefs About Sharing	Lu,  L,  Liu, et al	Health Educ Behav	Public Health Priorities| Priorités de santé publique Public Health response| Interventions de santé publique	China: This study examines the perceived trust of different COVID-19 information sources (health professionals, academic institutions, government agencies, news media, social media, family, and friends) and sharing of COVID-19 information in China.  Results suggest that health professionals, academic institutions, and government agencies are trusted sources of information and that people share information from these sources because they think doing so will increase disease awareness and promote disease prevention.
COVID-19 vaccine hesitancy among medical students	Lucia,  VC,  Kelekar, et al	J Public Health (Oxf)	Vaccine Research| Recherche sur les vaccins Public Health response| Interventions de santé publique	US medical students - vaccine hesitancy study:  Nearly all participants had positive attitudes towards vaccines and agreed they would likely be exposed to COVID-19; however, only 53% indicated they would participate in a COVID-19 vaccine trial and 23% were unwilling to take a COVID-19 vaccine immediately upon FDA approval. Students willing to immediately take the vaccine were more likely to trust public health experts, have fewer concerns about side effects and agree with vaccine mandates (P < 0.05). Concern for serious side effects was independently predictive of lower odds of intent to participate in a COVID-19 vaccine trial (AOR = 0.41, P = 0.01).
Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers	Lumley,  SF,  O'Donnell, et al	N Engl J Med	Epidemiology| Épidémiologie	UK HCWs: Oxford University Hospitals in the United Kingdom, 12 541 were followed up to 31 weeks.  A total of 12,541 health care workers participated and had anti-spike IgG measured; 11,364 were followed up after negative antibody results and 1265 after positive results, including 88 in whom seroconversion occurred during follow-up. A total of 223 anti-spike-seronegative health care workers had a positive PCR test (1.09 per 10,000 days at risk), 100 during screening while they were asymptomatic and 123 while symptomatic, whereas 2 anti-spike-seropositive health care workers had a positive PCR test (0.13 per 10,000 days at risk), and both workers were asymptomatic when tested (adjusted incidence rate ratio, 0.11; 95% confidence interval, 0.03 to 0.44; P = 0.002). There were no symptomatic infections in workers with anti-spike antibodies.  The presence of positive anti-spike or anti-nucleocapsid IgG antibodies was associated with a substantially reduced risk of SARS-CoV-2 reinfection in the ensuing 6 months.
Covid-19 incidence in europe: Drivers and government interventions	Lupu,  D,  Maha, et al	Transylvanian Review of Administrative Sciences	Epidemiology| Épidémiologie Public Health Priorities| Priorités de santé publique	This study aims to identify the determinant country-level factors that impact the trend of registered death cases from the recently emerged infectious disease COVID-19, analyzing data from March 2020 to July 2020, for 40 European countries.  The main result of the study is that a decreasing trend of death cases is the effect of a functional and citizen-oriented state, and is not only impacted by characteristics of the medical system or by individual features. Our findings also suggest that the premises for a low mortality rate are built by policies that have effects in the long-and medium-term. These policies refer to economic growth, sustainable development, healthcare, and the creation of a stable political system and an efficient administration.
Proteoforms of the SARS-CoV-2 nucleocapsid protein are primed to proliferate the virus and attenuate the antibody response	Lutomski,  CorinneA,  El-Baba, et al	bioRxiv	Coronavirology| Coronavirologie	The SARS-CoV-2 nucleocapsid (N) protein is the most immunogenic of the structural proteins and plays essential roles in several stages of the virus lifecycle. We find that dimers, and not monomers, of full-length N protein bind RNA, implying that dimers are the functional unit of ribonucleoprotein assembly. In addition, we find that N protein binds RNA with a preference for GGG motifs which are known to form short stem loop structures. Unexpectedly, we found that N undergoes proteolytic processing within the linker region, separating the two major domains.
Prone position ventilation and femoro-femoral veno-venous extracorporeal membrane oxygenation for COVID-19 treatment	Maeda,  A,  Nabeya, et al	Respirology Case Reports	Clinical data| Données cliniques	case report: we report the case of a healthy 52-year-old man who had respiratory failure owing to SARS-CoV-2 infection and was treated using femoro-femoral veno-venous extracorporeal membrane oxygenation (VV-ECMO) and prone position ventilation (PPV). After this treatment, his blood oxygen levels, chest high-resolution computed tomography findings, and clinical parameters significantly improved.
Co-infection of malaria and early clearance of SARS-CoV-2 in healthcare workers	Mahajan,  NN,  Gajbhiye, et al	J Med Virol	Epidemiology| Épidémiologie Clinical data| Données cliniques	India: Retrospective study was conducted at a dedicated COVID-19 hospital, BYL Nair Charitable Hospital (NH), Mumbai, India 6th April to 31st October 2020. The SARS-CoV-2 infection in HCWs was confirmed by RT-PCR. Out of 491 HCWs infected with SARS-CoV-2, analysis of viral clearance was carried out in 467 HCWs over seven month periods. Prevalence of SARS-CoV-2 infection in HCWs was 13% (491 out of 3711). The co-infection of malaria or dengue was reported in 31 HCWs (6.3%). The mean duration of virus clearance was longer (12 days) in symptomatic HCWs as compared to asymptomatic (8 days, p<0.005). The recovery of SARS-CoV-2 infection in HCWs was faster (mean 8 days) with co-infection of malaria than without malaria (p<0.005).
Risk mitigating behaviours in people with inflammatory skin and joint disease during the COVID-19 pandemic differ by treatment type: a cross-sectional patient survey	Mahil,  SK,  Yates, et al	Br J Dermatol	Public Health response| Interventions de santé publique	Online surveys were completed by individuals with psoriasis (globally) or Rheumatic and Musculoskeletal Diseases (RMD) (UK only) between 4th May and 7th September 2020.   3,720 participants (2,869 psoriasis, 851 RMD) from 74 countries, 2,262 (60.8%) reported the most stringent risk-mitigating behaviour (classified here under the umbrella term 'shielding'). A greater proportion of those receiving targeted therapies (biologics and JAK inhibitors) reported shielding compared to those receiving no systemic therapy (adjusted odds ratio OR] 1.63, 95% CI 1.35-1.97) and standard systemic agents (OR 1.39, 95% CI 1.22-1.56). Shielding was associated with established risk factors for severe COVID-19 (male sex OR 1.14, 95% CI 1.05-1.24], obesity OR 1.38, 95% CI 1.23-1.54], comorbidity burden OR 1.43, 95% CI 1.15-1.78]), a primary indication of RMD (OR 1.37, 95% CI 1.27-1.48) and a positive anxiety or depression screen (OR 1.57, 95% CI 1.36-1.80). Modest differences in the proportion shielding were observed across nations.
Forecasting of COVID-19 in Egypt and Oman using Modified SEIR and Logistic Growth Models	Mahmoud,  TMA,  Abu-Tafesh, et al		Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	Egypt and Oman:  modified SEIR and logistic growth, were implemented. Estimates for total number of cases and a sensitivity analysis are reported up to Aug2020
Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2 leading to universal blueprints for vaccine designs	Malone,  B,  Simovski, et al	Sci Rep	Coronavirology| Coronavirologie	To help achieve this ambitious aim, we have profiled the entire SARS-CoV-2 proteome across the most frequent 100 HLA-A, HLA-B and HLA-DR alleles in the human population and generated comprehensive epitope maps. We subsequently used these epitope maps as the basis for modeling the specific HLA haplotype of individual persons in a diverse set of different human populations using the most significant CD8 and CD4 T cell “epitope hotspots” in the virus. To the best of our knowledge, this is the first computational approach that generates comprehensive vaccine design blueprints from large-scale epitope maps of SARS-CoV-2 in a manner that optimizes for diverse T cell immune responses across the global population.
Novel Approach for Monte Carlo Simulation of the new COVID-19 Spread Dynamics	Maltezos,  Stavros,  Georgakopoulou, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	A Monte Carlo simulation in a novel approach is used for studying the problem of the outbreak and spread dynamics of the new COVID-19 pandemic in this work.
Emotional distress, psychosomatic symptoms and their relationship with institutional responses: A survey of Italian frontline medical staff during the Covid-19 pandemic	Marinaci,  T,  Carpinelli, et al	Heliyon	Mental Health | santé mentale	Italy HCWs:  103 questionnaires were collected. emotional distress (ED) and psychosomatic symptoms (PS). out half of the health workers showed medium or high scores on emotional exhaustion, exceeded the cut-off for medium, high or very high psychosomatic symptom burdens, felt they have never or rarely been protected by the institutional responses and judged the emotional support received as inadequate; 32% judged the safety and hygiene measures as insufficient. Significant associations were found between measures of ED, PS and perceived change in personal wellbeing. Differences in perceived institutional support and adequacy of hygiene and safety measures related to significant differences in PS and perceived change in personal wellbeing. ED and PS were widely experienced by frontline health workers. Physical and psychological symptoms were amplified by the perceived lack of institutional support. Ensuring PS and hygiene and safety measures is essential to prevent worsening of health and psychosomatic symptoms in frontline health workers.
Giving birth during the COVID-19 pandemic: The impact on birth satisfaction and postpartum depression	Mariño-Narvaez,  C,  Puertas-Gonzalez, et al	Int J Gynaecol Obstet	Mental Health | santé mentale	Spain, case control study, 162 pregnant women were  assessed using psychological instruments for postpartum childbirth satisfaction and postpartum depression.  It was found that women who gave birth during the pandemic suffered higher levels of stress during childbirth (U = 2652.50; p = .040) and gave a worse rating of the quality of care received (U = 2703.50; p = .041). In addition, the percentage of postpartum depression was much higher in women who gave birth during the pandemic (ꭓ(2) = 4.31; p = .038).
No cases of asymptomatic SARS-CoV-2 infection among healthcare staff in a city under lockdown restrictions: lessons to inform 'Operation Moonshot'	Martin,  CA,  Jenkins, et al	J Public Health (Oxf)	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	Leicester UK: Between 20 July and 14 August 2020 during a local lockdown, HCWs were tested by nucleic acid amplification (NAAT).  A total of 1150 staff (~8% of the workforce) volunteered. The median age was 46 years (IQR 34-55), 972 (84.5%) were female; 234 (20.4%) were of South Asian and 58 (5.0%) of Black ethnicity; 564 (49.0%) were nurses/healthcare assistants. We found no cases of asymptomatic infection. In comparison, average community test positivity rate in Leicester city was 2.6%.
Real-world prevalence and consequences of potential drug-drug interactions in the first-wave COVID-19 treatments	Martínez-López-de-Castro,  N,  Samartín-Ucha, et al	J Clin Pharm Ther	Clinical data| Données cliniques	Cohort, retrospective and single-centre study carried out in a third-level hospital.  Potential drug-drug interactions (pDDIs) derived from the medication used in COVID-19 patients. Two hundred and eighteen (62.3%) patients of a total of 350 patients admitted with COVID-19 had at least one pDDI. There were 598 pDDIs. Thirty-eight pDDIs (6.3%) were categorized as not recommended or contraindicated. The mean value difference between baseline and pDDI posterior ECG was 412.3 ms ± 25.8 ms vs. 426.3 ms ± 26.7 ms; p < 0.001. Seven patients (5.7%) had a clinically significant alteration of QTc. A total of 44 non-cardiological events (7.3%) with a possible connection to a pDDI were detected.
PMC7538392; Were Clinical Routines for Good End-of-Life Care Maintained in Hospitals and Nursing Homes During the First Three Months of the Outbreak of COVID-19? A National Register Study	Martinsson,  L,  Strang, et al	J Pain Symptom Manage	Healthcare Response | Réponse des soins de santé	Hospital and long-term care homes in Sweden: Data about five items reflecting clinical routines for persons who died an expected death from COVID-19 during the first three months of the pandemic (March-May 2020) were collected from the Swedish Register of Palliative Care. 1316 expected deaths were identified in nursing homes and 685 in hospitals. Four of the five items differed for total COVID-19 group compared with the reference cohort: fewer were examined by a physician during the last days before death, pain and oral health were less likely to be assessed, and fewer had a specialized palliative care team consultation (P < 0.0001, respectively). Assessment of symptoms other than pain did not differ significantly. The five items differed between the nursing homes and hospitals in the COVID-19 group, most notably regarding the proportion of persons examined by a physician during the last days (nursing homes: 18%; hospitals: 100%).
Motivators of and barriers to becoming a COVID-19 convalescent plasma donor: A survey study	Masser,  BM,  Ferguson, et al	Transfus Med	Public Health response| Interventions de santé publique	motivators and barriers to COVID-19 convalescent plasma donation by those in the United Kingdom.  419 UK residents who indicated that they had been infected with COVID-19 and who lived within 50 km of sites collecting COVID-19 convalescent plasma completed an online survey between 25th June and 5th July 2020.  Awareness of COVID-19 convalescent plasma was low. Exploratory factor analysis identified six motivations and seven barriers to donating. A stronger sense of altruism through adversity and moral and civic duty were positively related to intention to donate, whereas generic donation fears was negatively related.
TCR meta-clonotypes for biomarker discovery with tcrdist3: quantification of public, HLA-restricted TCR biomarkers of SARS-CoV-2 infection	Mayer-Blackwell,  Koshlan,  Schattgen, et al	bioRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	We propose a new framework that leverages antigen-enriched repertoires to form meta-clonotypes – groups of biochemically similar TCRs – that can be used to robustly quantify functionally similar TCRs in bulk repertoires. We apply the framework to TCR data from COVID-19 patients, generating 1,915 public TCR meta-clonotypes from the 18 SARS-CoV-2 antigen-enriched repertoires with the strongest evidence of HLA-restriction. Applied to independent cohorts, meta-clonotypes targeting these specific epitopes were more frequently detected in bulk repertoires compared to exact amino acid matches, and 44% (845/1915) were significantly enriched among COVID-19 patients that expressed the putative restricting HLA allele, demonstrating the potential utility of meta-clonotypes as antigen-specific features for biomarker development
Frequency of Contact and Explanations for Increased Contact between Grandchildren and Their Grandparents during the COVID-19 Pandemic	McDarby,  M,  Ju, et al	Journal of Intergenerational Relationships	Public Health response| Interventions de santé publique	Intergenerational Solidarity Theory as a framework. Young adults (N= 165) completed an online survey about contact with grandparents before and during the pandemic. . Median frequency of grandchild-initiated contact with grandparents increased marginally during the pandemic, and higher ratings of affectual solidarity toward grandparents were significantly associated with increases in frequency of contact. Ratings of grandparents’ physical and mental health were not significantly associated with changes in frequency of contact from before the pandemic to during the pandemic. The most common explanation for increased contact with grandparents during the pandemic reported by study participants was concern about COVID-19.
A method for prioritizing risk groups for early SARS-CoV-2 Vaccination, By the Numbers	McDonald,  ClementJ,  Baik, et al	medRxiv	Vaccine Research| Recherche sur les vaccins	Prioritization of risk groups for vaccine: Our predictive model ranked all demographic groups by COVID-19 death risk. It was highly concentrated in some demographic groups, e.g. 85+ year old Black, Non-Hispanic patients suffered 1,953 deaths per 100,000. If we vaccinated the 17 demographic groups at highest COVID-19 death ranked by our logistic model, it would require only 3.7% of the vaccine supply needed to vaccinate all the United States, and yet prevent 47% of COVID-19 deaths.  Nursing home residents had a higher COVID-19 death risk at 5,200 deaths/100,000, more than our highest demographic risk group. Risk of prison residents and health care workers (HCW) were lower than that of our demographic groups with the highest risks.
Development and external validation of a COVID-19 mortality risk prediction algorithm: a multicentre retrospective cohort study	Mei,  J,  Hu, et al	BMJ Open	Clinical data| Données cliniques	China, Retrospective cohort study  8 January and 19 March 2020.  1364 COVID-19 cases. Predicting all-cause mortality: seven predictors of age, respiratory failure, white cell count, lymphocytes, platelets, D-dimer and lactate dehydrogenase. The simple model contained five indicators of age, respiratory failure, coronary heart disease, renal failure and heart failure. After cross-validation, the AUC statistics based on derivation cohort were 0.96 (95% CI, 0.96 to 0.97) for the full model and 0.92 (95% CI, 0.89 to 0.95) for the simple model. The AUC statistics based on the external validation cohort were 0.97 (95% CI, 0.96 to 0.98) for the full model and 0.88 (95% CI, 0.80 to 0.96) for the simple model.
Oxygen saturation as a predictor of mortality in hospitalized adult patients with COVID-19 in a public hospital in Lima, Peru	Mejía,  F,  Medina, et al	PLoS One	Epidemiology| Épidémiologie Clinical data| Données cliniques	Peru, retrospective cohort study among adult patients with COVID-19 admitted to Hospital Cayetano Heredia,  369 patients Most patients (68.56%) reported at least one comorbidity; more frequently: obesity (42.55%), diabetes mellitus (21.95%), and hypertension (21.68%). The median duration of symptoms prior to hospital admission was 7 days (IQR: 5-10). Reported in-hospital mortality was 49.59%. By multiple Cox regression, oxygen saturation (SaO2) values of less than 90% on admission correlated with mortality, presenting 1.86 (95%CI: 1.02-3.39), 4.44 (95%CI: 2.46-8.02) and 7.74 (95%CI: 4.54-13.19) times greater risk of death for SaO2 of 89-85%, 84-80% and 90%. Additionally, age >60 years was associated with 1.88 times greater mortality.
A case of sars-cov-2-associated multisystem inflammatory syndrome in an 8-year-old child	Melekhina,  EV,  Nikolaeva, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Clinical data| Données cliniques	in Russian, case report: MIS-C in an 8 year old is described.
Poverty and survival from COVID-19 in Mexico	Millán-Guerrero,  RO,  Caballero-Hoyos, et al	J Public Health (Oxf)	Epidemiology| Épidémiologie	Mexico Retrospective cohort study. Secondary data was used to define the exposure (multidimensional poverty level) and outcome (survival time) among patients diagnosed with COVID-19 between 27 February and 1 July 2020. Nearly 250 000 COVID-19 patients were included. Mortality was 12.3% reaching 59.3% in patients with ≥1 comorbidities. Multivariate survival analyses revealed that individuals living in municipalities with extreme poverty had 9% higher risk of dying at any given time proportionally to those living in municipalities classified as not poor (HR 1.09; 95% CI 1.06-1.12). The survival gap widened with the follow-up time up to the third to fourth weeks after diagnosis.
Atypical course of COVID-19 in patient with Bruton agammaglobulinemia	Milošević,  I,  Jovanović, et al	Journal of infection in developing countries	Clinical data| Données cliniques	Case reprot: COVID-19 in 34-year man with Bruton agammaglobulinemia. The patient was successfully treated by a combination of available drugs, including convalescent plasma and interleukin-6 (IL-6) inhibitor.
In silico design of Multi-epitope-based peptide vaccine against SARS-CoV-2 using its spike protein	Mitra,  Debarghya,  Pandey, et al	bioRxiv	Coronavirology| Coronavirologie	In silico structure-based approach utilizing a combination of epitope prediction servers and Molecular dynamic (MD) simulations to develop a multi-epitope-based subunit vaccine that involves the two subunits of the spike glycoprotein of SARS-CoV-2 (S1 and S2) coupled with a substantially effective chimeric adjuvant to create stable vaccine constructs. The designed constructs were evaluated based on their docking with Toll-Like Receptor (TLR) 4. Our findings provide an epitope-based peptide fragment that can be a potential candidate for the development of a vaccine against SARS-CoV-2.
Development of a high-throughput SARS-CoV-2 antibody testing pathway using dried blood spot specimens	Moat,  SJ,  Zelek, et al	Ann Clin Biochem	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Testing: enzyme-linked immunosorbent assay to detect IgG antibodies against the receptor-binding domain of the SARS-CoV-2 spike protein in dry blood spot (DBS) specimens. Paired plasma and DBS specimens from SARS-CoV-2 antibody-positive and -negative subjects and polymerase chain reaction positive subjects were tested. DBS specimens from antibody-negative (n = 85) and -positive (n = 35) subjects and polymerase chain reaction positive subjects (n = 11) had a mean (SD; range) optical density (OD) of 0.14 (0.046; 0.03-0.27), 0.98 (0.41; 0.31-1.64) and 1.12 (0.37; 0.49-1.54), respectively. An action value OD >0.28 correctly assigned all cases. The weighted Deming regression for comparison of the DBS and the plasma assay yielded: y = 0.004041 + 1.005x, r = 0.991, Sy/x 0.171, n = 82. Extraction efficiency of antibodies from DBS specimens was >99%. DBS specimens were stable for at least 28 days at ambient room temperature and humidity.
Prediction of proteins associated with covid-19 based ligand designing and molecular modeling	Monajjemi,  M,  Esmkhani, et al	CMES - Computer Modeling in Engineering and Sciences	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Detail docking studies on the major virus protease with 4 natural product species as anti COVID-19 (SARS-CoV-2), namely “Vidarabine”, “Cytarabine”, “Gemcitabine” and “Matrine” which have been extracted from Gillan's leaves plants. Cytarabine appears as a suitable compound with high effectiveness inhibitors to this protease.
Evaluation of sars-cov-2 existence in blood, urine, and rectal swab in positive patients with different virus titers	Mondanizadeh,  M,  Hrahimi, et al	Jundishapur Journal of Microbiology	Clinical data| Données cliniques	The virus shedding in the upper respiratory as well as blood, stool, and urine specimens of infected patients, was examined using quantitative real-time PCR assay (qRT-PCR). The viral genome was diagnosed in 5% of blood and 3.3% of rectal swab samples.
Erythema annulare centrifugum with anosmia and ageusia in a SARS-CoV-2 exposed patient successfully treated with doxycycline	Montinari,  M,  Atzori, et al	Int J Dermatol	Clinical data| Données cliniques	A 35‐year‐old Italian woman working in a cosmetic manufacturing industry  diagnosed with Erythema annulare centrifugum with anosmia and ageusia.
Internal carotid artery thrombosis in COVID 19: Case report	Moreno,  YÁ,  Figueroa, et al	Colombia Medica	Clinical data| Données cliniques	Case description of  a 37-year-old female with PCR-RT swab for COVID-19 positive, with neurological manifestation as a result of internal carotid artery occlusion.
Emerging SARS-CoV-2 diversity revealed by rapid whole genome sequence typing	Moustafa,  AhmedM,  Planet, et al	bioRxiv	Epidemiology| Épidémiologie Coronavirology| Coronavirologie	Developed a tool (GNUVID) that integrates whole genome multilocus sequence typing and a supervised machine learning random forest-based classifier. The tool was used to assign sequence type (ST) profiles to each of 69,686 SARS-CoV-2 complete, high-quality available genomes. Classification tool uncovered multiple introduction and exportation events, as well as waves of expansion and replacement of SARS-CoV-2 genotypes in different states.
Identification of Novel MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating the EGFR-ADAM17 Axis: An in Silico Analysis	Mukhopadhyay,  D,  Alsawaftah, et al	ACS Pharmacology and Translational Science	Clinical data| Données cliniques	Cancer patients contracting SARS-CoV-2 encounter additional challenges due to inflammatory bursts and lymphopenia, which may aggravate breast cancer prognosis. In this in silico analysis, the potential of miRNAs as new therapeutic targets to treat breast cancer patients infected with COVID-19 via the regulation of ADAM17 and EGFR expression microRNAs was considered.
The psychiatric sequelae of the COVID-19 pandemic in adolescents, adults, and health care workers	Murata,  S,  Rezeppa, et al	Depress Anxiety	Mental Health | santé mentale	Assess mental health impacts of COVID-19 across the lifespan in the United States in adolescents, adults, and health care workers. Adolescents were significantly more likely to report moderate to severe symptoms of depression, anxiety, PTSD, suicidal ideation or behavior, and sleep problems compared to adults. The rates of intense grief reactions among those who lost someone to COVID‐19 was 55%. Loneliness was the most common predictor across outcomes and higher number of hours spent on social media and exposure to media on COVID‐19 predicted depression symptoms and suicidal ideation or behaviors.
The pandemic in family practice – a practice report on sars-cov-2	Murr,  D,  Schelling, et al	Zeitschrift fur Allgemeinmedizin	Healthcare Response | Réponse des soins de santé	Examines first effects of the COVID-19 pandemic on patient care and workflow in one family practice., in Germany. Throughout the study period, there was a decrease of 34.7 %. Numbers of phone calls related to Corona were rare and declining, as did communications  related to “other infections”.  A larger number was caused by patients experiencing acute, non-infectious illnesses. Administrative calls were the most frequent and increasing category observed.
Investigating the origin of the Belgian second SARS-CoV-2 wave by using (pre)admission screening samples	Naesens,  Reinout,  Heireman, et al	medRxiv	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	Estimate rates of SARS-CoV-2 carriership and viral loads in the general Antwerp population and to compare the estimated prevalences and incidences with governmental data (numbers of detected positive cases, stringency measure index) in order to evaluate the dynamics leading to the second wave. High SARS-CoV-2 carriership rates (mean week prevalence of 1.3%) were found in the general Antwerp population. 35.4% of positive cases carried high viral loads. Only a small proportion (15.3%) of the viral circulation was detected by the nationally implemented testing policy. In the weeks before the second Belgian wave, increasing prevalences and incidences were found, together with country-wide easing of restriction measures.
Disruption of nasal bacteria enhances protective immune responses to influenza A virus and SARS-CoV-2 infection in mice	Nagai,  Minami,  Moriyama, et al	bioRxiv	Vaccine Research| Recherche sur les vaccins Animal model | Modèle animal	Demonstrate that while intranasal administration of influenza virus hemagglutinin vaccine alone was insufficient to induce the vaccine-specific antibody responses, disruption of nasal bacteria by lysozyme or addition of culturable oral bacteria from a healthy human volunteer rescued inability of the nasal bacteria to generate antibody responses to intranasally administered the split-virus vaccine.  Found that the oral bacteria-combined intranasal vaccine induced protective antibody response to influenza virus and SARS-CoV-2 infection.
Inferring Toll-Like Receptor induced epitope subunit vaccine candidate against SARS-CoV-2: A Reverse Vaccinology approach	Nayak,  Ananya,  Gadnayak, et al	bioRxiv	Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins	Study used the reverse vaccinology approach by using a complete set of SARS-CoV-2 proteins; such as: Spike, Envelope, Nucleocapsid, Membrane, NSPs, and ORFs to extract the antigenic elements that produce B-cell, T-cell and IFN positive epitopes. These epitopes with precise binding to the Toll-Like receptors (1-10) have developed epitope based vaccine candidates. The selected epitopes were employed for in-silico docking interactions with Toll-Like receptors and molecular dynamic simulation confirmed the stability of the vaccine candidates resulting epitope of spike proteins with both the TLR 7 and 8 shows the best binding affinity.
Analysis and Forecasting of Global of RT-PCR Primers for SARS-CoV-2	Nayar,  Gowri,  Seabolt, et al	bioRxiv	Coronavirology| Coronavirologie Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Analyze the performance of the SARS-CoV-2 primers in use today by measuring the number of mismatches between primer sequence and genome targets over time and spatially. Find that there is a growing number of mismatches, an increase by 2% per month, as well as a high specificity of virus based on geographic location.
Establishment of a well-characterized SARS-CoV-2 lentiviral pseudovirus neutralization assay using 293T cells with stable expression of ACE2 and TMPRSS2	Neerukonda,  Sabari Nath,  Vassell, et al	bioRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Report on efforts to optimize and characterize an HIV-based lentiviral pseudovirus assay for screening neutralizing antibodies for SARS-CoV-2 using a stable 293T cell line expressing human angiotensin converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2).
Losartan promotes cell survival following SARS-CoV-2 infection in vitro	Nejat,  Reza,  Sadr, et al	bioRxiv	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Losartan treatment of Vero E6 cells prior to and after SARS-CoV-2 infection reduced SARS-CoV-2 replication by 80% and 70% respectively. Losartan was not a strong deubiquitinase and deISGylase inhibitor of PLpro. Losartan added pre- and post-infection to the Vero E6 cell culture significantly prevents cell destruction and replication by SARS-CoV2
Clinical Characteristics and Outcomes of Non-ICU Hospitalization for COVID-19 in a Nonepicenter, Centrally Monitored Healthcare System	Nemer,  DM,  Wilner, et al	J Hosp Med	Epidemiology| Épidémiologie Clinical data| Données cliniques	The clinical characteristics and outcomes associated with non–intensive care unit (non-ICU) hospitalizations for coronavirus disease 2019 (COVID-19) outside disease epicenters. Among non–critically ill patients hospitalized within a nonepicenter health care system, overall survival was 94% with the development of more severe illness or death independently associated with higher levels of C-reactive protein and lactate dehydrogenase on admission. Clinical decompensation was largely respiratory-related, while serious cardiac arrhythmias were rare, which suggests that telemetry can be prioritized for high-risk patients.
Analysing Public Opinion and Misinformation in a COVID-19 Telegram Group Chat	Ng,  HXL,  Loke, et al	IEEE Internet Computing	Public Health response| Interventions de santé publique	Analyse a Singapore-based COVID-19 Telegram group with more than 10,000 participants. First, we study the group's opinion over time, focusing on five dimensions: participation, sentiment, negative emotions, topics, and message types.
Time Course Analysis of Age-Gender Effect on Severity of COVID-19 Outbreak in Spain and Italy	Niedostatek,  Marta,  Valsecchi, et al	Research Square prepub	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	A wide range of variables on the severity of COVID-19 in relation to gender and age, are analysed over an extended time course from March 2020 to when data are publicly available. Spanish and Italian data only are considered
Serial population-based sero-surveys for COVID-19 in low and high transmission neighborhoods of urban Pakistan	Nisar,  Muhammad Imran,  Ansari, et al	medRxiv	Epidemiology| Épidémiologie Immunology | Immunologie	Apply population-based estimates of COVID-19 in a densely populated urban community of Karachi, Pakistan to find the initial rapid increase in seroprevalence was followed by a plateau in the later phase of the pandemic in Karachi.
COVID-19 infection among first responders in Broward County, Florida, March-April 2020	Niu,  J,  Rodriguez, et al	J Public Health (Oxf)	Epidemiology| Épidémiologie	The FRs in Broward County, FL, had an overall infection rate of 8.6% at the time of COVID-19 testing, and asymptomatic FRs accounted for 81.3% of infection. A total of 3375 FRs were screened for COVID-19 infection. The median age of FRs tested was 42 years (IQR 33–52 years), and 1464 (43.4%) were men.
Optimization of a molecular diagnostic strategy to verify SARS-CoV-2 infections by RT-qPCR	Noßmann,  M	Journal of Laboratory Medicine	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Improved protocol to extract purify RNA molecules from SARS-CoV-2  compared to a bead-based RNA extraction method using previously positive tested samples. Study suggests that virus capsid lysis combined with nucleic acid purification enables a viable alternative for the molecular diagnostics of SARS-CoV-2 infections.
Re: Moore et al., Detection of SARS-CoV-2 within the healthcare environment: a multicentre study conducted during the first wave of the COVID-19 outbreak in England, Journal of Hospital Infection, 2020	Nunes,  TR,  Zanella, et al	J Hosp Infect	Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé	Performed a prospective quality control study to assess surface contamination at Geneva University Hospitals, a tertiary care center in Switzerland. Surface sampling was performed according to WHO guidelines [7], in COVID- and non-COVID-units (two intermediate care, two geriatrics and one mixed unit with separate sectors for COVID- and non-COVID patients). In total, SARS-CoV-2 RNA was detected in 7/184 (3.8%) samples. All positive samples were collected in COVID-units, with a detection rate of 8.3% (7/84),
Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein	Nuovo,  GJ,  Magro, et al	Ann Diagn Pathol	Coronavirology| Coronavirologie Animal model | Modèle animal	The S1 subunit of the SARS-CoV-2 spike protein has the ACE2 recognition site. The S1 subunit causes degeneration of endothelial cells and motor neurons in cell culture. The S1 subunit alone when injected into mice causes a systemic endothelialopathy. Damage to ACE2+ endothelial cells is the key feature of human COVID-19 and the mouse model of the disease.
Rapid inactivation in vitro of SARS-CoV-2 in saliva by black tea and green tea	Ohgitani,  Eriko,  Shin-Ya, et al	bioRxiv	Therapeutics| Thérapeutique	Reported that black, green and oolong tea significantly inactivated SARS-CoV-2 within 1 min. Treatment of SARS-CoV-2 with 500 μM TFDG or TSA for 10 sec reduced the virus titer to undetectable levels (less than 1/1,000). Black and green tea decreased virus titer to less than 1/100 within 10 sec even in saliva.
Safe but Lonely? Loneliness, Anxiety, and Depression Symptoms and COVID-19	Okruszek,  Ł,  Aniszewska-Stańczuk, et al	Frontiers in Psychology	Mental Health | santé mentale	Used cross-sectional (n = 380) and longitudinal (n = 74) designs to investigate the links between loneliness, anxiety, and depression symptoms (ADS) and COVID-19 risk perception and affective response in young adults who implemented social distancing during the first 2 weeks of the state of epidemic threat in Poland. Loneliness was correlated with ADS and with affective response to COVID-19’s threat to health. However, increased worry about the social isolation and heightened risk perception for financial problems was observed in lonelier individuals. The cross-lagged influence of the initial affective response to COVID-19 on subsequent levels of loneliness was also found.
An Analysis of COVID-19 Patients Receiving Care in a Tertiary Facility in Southern Nigeria	Okwara,  BU,  Ogboghodo, et al	West African journal of medicine	Epidemiology| Épidémiologie Clinical data| Données cliniques	Describe the presenting characteristics, co-morbidities and outcomes of Nigerian patients managed over a 3-month period in a tertiary hospital. A total of 173 patients with mean age (SD) 50.7± 20.1 years were managed. One hundred and five (60.7%) were males and the commonest age group was 20-39 years (34.7%). The commonest presenting symptoms were fever, cough and malaise found in 103 (71.5%), 101 (70.1%) and 63 (43.8%) patients respectively. Twenty-five (14.5%) patients had severe disease; 60 (34.7%) had underlying medical conditions mostly hypertension and diabetes mellitus. Outcome analyses showed 117 (67.6%) discharges, 45 (26.0%) deaths, 10 (5.8%) discharges against medical advice, and 1 (0.6%) transfer to another facility. Male sex, increasing age, presence of symptoms (p=0.010), presence of co-morbidities and non-healthcare worker status were significantly associated with mortality.
De novo acquired hemophilia as an immune dysregulation phenomenon following SARS-CoV-2 infection	Olsen,  GM,  Rinder, et al	Transfusion	Clinical data| Données cliniques	Clinical case of an 83 year old female  of de novo acquired hemophilia as an immune dysregulation phenomenon following SARS-CoV-2 infection.
Nonrespiratory Complications and Obesity in Patients Dying with COVID-19 in Italy	Onder,  G,  Palmieri, et al	Obesity	Epidemiology| Épidémiologie Clinical data| Données cliniques	Assess the impact of obesity on non-respiratory complications in patients dying with coronavirus disease (COVID-19).Medical charts of 3,694 of patients dying with COVID-19 in Italy were reviewed to extract information on demographics, preexisting comorbidities, and in-hospital complications leading to death. Obesity was present in 411/3,694 (11.1%) patients dying with COVID-19. Obesity was significantly associated with increased probability of experiencing acute renal failure (adjusted odds ratio [OR], 1.33; 95% CI: 1.04-1.71) and shock (adjusted OR, 1.54; 95% CI: 1.19-1.99). The associations of obesity with acute renal failure and shock were stronger in patients aged < 60 years (adjusted OR, 2.00; 95% CI: 1.09-3.67 and OR, 2.37; 95% CI 1.29-4.36) than in those aged 60 years or older (adjusted OR, 1.20; 95% CI: 0.90-1.60 and OR, 1.22; 95% CI: 0.91-1.65).
Psychiatric Symptoms during the COVID-19 outbreak in Older Adults with Bipolar Disorder	Orhan,  M,  Korten, et al	Int J Geriatr Psychiatry	Mental Health | santé mentale	Participants experienced less psychiatric symptoms during COVID‐19 than (67.9% euthymic) than at baseline (40.7% euthymic). There was no difference in loneliness between COVID‐19 and baseline. Not having children, more feelings of loneliness, lower mastery, passive coping style and neuroticism were associated with more psychiatric symptoms during COVID‐19 measures.
Application of real-time PCR to significantly reduce the time to obtain recombinant MVA virus	Orlova,  OV,  Glazkova, et al	J Virol Methods	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Describe a novel single-tube real-time PCR which enables determination of the amount of wild type and recombinant viruses and their ratio in plaques. The new approach has been applied to generate recombinant MVAs encoding different SARS-COV-2 antigens.
Neuropsychological and neurophysiological correlates of fatigue in post-acute patients with neurological manifestations of COVID-19: Insights into a challenging symptom	Ortelli,  P,  Ferrazzoli, et al	Journal of the neurological sciences	Long-Term Sequelae | séquelles à long terme	More than half of patients who recover from COVID-19 experience fatigue. Studied fatigue using neuropsychological and neurophysiological investigations in post-COVID-19 patients and healthy subjects. Patients manifested fatigue, apathy, executive deficits, impaired cognitive control, and reduction in global cognition. Perceived exertion was higher in patients.
Prolonged SARS-CoV-2 viral shedding in patients with chronic kidney disease	O'Sullivan,  ED,  Lees, et al	Nephrology (Carlton)	Epidemiology| Épidémiologie Clinical data| Données cliniques	A cross‐sectional observational study of 138 patients admitted with SARS‐CoV‐2 infection at two large regional hospitals in Scotland, UK examined the median time to two consecutive negative nasopharyngeal swabs for SARS‐CoV‐2 in an inpatient population. The median time from admission to the first of two consecutive negative nasopharyngeal swabs was 18 days (range = 1‐44) in patients with CKD, compared with 11 days (range: 1‐71) in patients without CKD (P = .0007).
Prolonged SARS-CoV-2 viral shedding in patients with chronic kidney disease	O'Sullivan,  ED,  Lees, et al	Nephrology (Carlton)	Epidemiology| Épidémiologie Clinical data| Données cliniques	A cross‐sectional observational study of 138 patients admitted with SARS‐CoV‐2 infection at two large regional hospitals in Scotland, UK examined the median time to two consecutive negative nasopharyngeal swabs for SARS‐CoV‐2 in an inpatient population. The median time from admission to the first of two consecutive negative nasopharyngeal swabs was 18 days (range = 1‐44) in patients with CKD, compared with 11 days (range: 1‐71) in patients without CKD (P = .0007).
Self-help in times of COVID-19	Otero-Ramos,  I,  Fernández-Castillo, et al	Revista Cubana de Medicina Militar	Mental Health | santé mentale	Propose self-help bulletins as psychological support tools to promote coping strategies in the face of the crisis generated by COVID-19.
Multisystem inflammatory syndrome in children associated with new coronavirus infection (Covid-19): Clinical and morphological comparisons	Ovsyannikov,  DY,  Novikova, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Clinical data| Données cliniques	Multisystem Inflammatory Syndrome in Children (MIS-C) associated with new coronavirus infection (COVID-19), with signs of Kawasaki disease (KD) and toxic shock syndrome, well-defined diagnostic criteria, is the most severe manifestation of COVID-19 in pediatric patients. MIS-C is analogous to the cytokine storm in children with COVID-19. The article presents a clinical observation of a child with MIS-C with a lethal outcome.
Design and in silico study of the novel coumarin derivatives against SARS-CoV-2 main enzymes	Özdemir,  M,  Köksoy, et al	J Biomol Struct Dyn	Coronavirology| Coronavirologie	Study focuses on factors that increase the molecular binding and antiviral properties of coumarins. Molecular docking studies have been carried out to five different proteins (Spike S1-subunit, NSP5, NSP12, NSP15, and NSP16) of the SARS-CoV-2 and two proteins (ACE2 and VKORC1) of human. The best binding scores for 17 coumarins were determined for NSP12 (NonStructural Protein-12). The highest score (–10.01 kcal/mol) in the coumarin group is 2-morpholinoethan-1-amine substituted coumarin. Molecular mechanics Poisson-Boltzmann surface area (MM-PBSA) analyses of selected ligand-protein complexes were performed. The binding energies in each 5 ns were calculated and it was found that the interaction between ligand and target protein were stable.
Weighted Cross-Entropy for Unbalanced Data with Application on COVID X-ray images	Ozdemir,  O,  Sonmez, et al		Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Investigates on the performance of a very well known residual network, ResNet50, and a lightweight Atrous CNN (ACNN) network using a Weighted Cross-entropy (WCE) loss function, to alleviate imbalance on COVID datasets. As a result, ResNet50 model initialized with pre-trained weights fine-tuned by ImageNet dataset and exploiting WCE achieved the state-of-the-art performance on COVIDXRay-5K test set, with a top balanced accuracy of 99.87%.
Health anxiety status of elite athletes in COVID-19 social isolation period	Ozen,  G,  Koc, et al	Bratislavske lekarske listy	Mental Health | santé mentale	Examine the health anxiety states and behaviours of athletes during the social isolation period due to COVID-19 pandemic. Findings revealed that athletes who were tested for COVID-19 and who thought they had symptoms of the disease had higher levels of health anxiety and athletes who reported a temporary loss in athletic performance had higher disease anxiety.
Establishment and validation of competitive ELISA for detecting blocking activity of monoclonal antibody against SARS-CoV-2 RBD	Pan,  YB,  Zhang, et al	Chinese Journal of New Drugs	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Establish and verify a competitive ELISA method for the detection of blocking activity of monoclonal antibody against SARS-CoV-2 RBD, and to compare the results by correlation analysis with that of live virus neutralization activity measured by the plaque reduction neutralization test (PRNT).
FACE COVERING ADHERENCE IN AN OUTPATIENT OPHTHALMOLOGY CLINIC DURING COVID-19	Parikh,  A,  Kondapalli, et al	Ophthalmic Epidemiol	Public Health response| Interventions de santé publique Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé	Examine the proper use of face coverings by patients entering one of several outpatient ophthalmology clinics during the coronavirus disease 19 (COVID-19) global pandemic. Over 5 days, 43 of 2286 patients (2%) that entered one of the participating clinics were observed not or incorrectly wearing face coverings. The average age of patients who were not correctly wearing a face covering was significantly higher. There was no association between gender and face-covering use.
Forward-looking serial intervals correctly link epidemic growth to reproduction numbers	Park,  SW,  Sun, et al	Proc Natl Acad Sci U S A	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	Show that estimating R based on r and the serial interval distribution, when defined from the correct reference cohort, gives the same estimate as using r and the generation interval distribution. Apply the outlined framework to COVID-19 serial interval data from China, outside Hubei province (January 21 to February 8, 2020), revealing systematic biases in prior inference methods. Our study provides the theoretical basis for practical changes to the principled use of serial interval distributions in estimating R during epidemics.
Range of reproduction number estimates for COVID-19 spread	Pasetto,  D,  Lemaitre, et al	Biochemical and biophysical research communications	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	Compute control reproduction numbers from Swiss and Italian COVID-19 time series adopting both data convolution (renewal equation) and a SEIR-type model. Within these two paradigms, authors run a comparative analysis of the possible inferences obtained through approximations of the distributions typically used to describe serial intervals, generation, latency and incubation times, and the delays between onset of symptoms and notification. Results suggest that estimates of reproduction numbers under these different assumptions may show significant temporal differences, while the actual variability range of computed values is rather small.
Relationship knowledge transmission of covid-19 and fear of dental care during pandemic in South Sulawesi, Indonesia	Pasiga,  BD	Pesquisa Brasileira em Odontopediatria e Clinica Integrada	Healthcare Response | Réponse des soins de santé	Respondents who experienced "dental health problems" during the pandemic were 44.7%. The knowledge of respondents about the transmission of the COVID-19 virus in dental care was 79.9% and the knowledge of the fear of caring during the pandemic period was 31.85% afraid. Statistical analysis showed a significant relationship between knowledge about transmission of the COVID-19 virus and fear of dental care (rs=0.388, p<0.001).
Potential role of host-mediated RNA editing in intra-host variability of SARS-CoV-2 genomes	Pathak,  AnkitK,  Fatihi, et al	bioRxiv	Epidemiology| Épidémiologie Coronavirology| Coronavirologie	Using 1,347 transcriptomes of COVID-19 infected patients across various populations, we find variable prevalence of intra-host single-nucleotide variations (iSNVs) with distinctly higher levels in Indian population. Results also suggest that iSNVs can likely establish variants in a population and may also contribute to key structural and functional changes in the Spike protein that confer antibody resistance.
PMC7756171; Computational and Network Pharmacology Analysis of Bioflavonoids as Possible Natural Antiviral Compounds in Covid-19	Patil,  R,  Chikhale, et al	Inform Med Unlocked	Therapeutics| Thérapeutique	Bioflavonoids are potential antiviral secondary metabolites. Docking, MD and network pharmacology demonstrated antiviral & adjuvant potential. MM-PBSA calculations and network pharmacology identified key bioflavonoids. Mulberroside, Glycyrrhizic acid and Amentoflavone may hold promise in COVID-19.
Psychological Resources Protect Well-Being During the COVID-19 Pandemic: A Longitudinal Study During the French Lockdown	Pellerin,  N,  Raufaste, et al	Frontiers in Psychology	Mental Health | santé mentale	Results show that psychological resources efficiently protected well-being in a variety of ways: they buffered the adverse effects of reported threats to health and wealth, increased the well-being averages, and reduced the decline in well-being over time. More specifically, emotional well-being was positively predicted by hope, gratitude of being, and, to a lesser level, by acceptance; psychological well-being by self-efficacy, personal wisdom, and gratitude of being; social well-being only by gratitude toward the world; and inner well-being by optimism, gratitude of being, and acceptance.
Prediction of severe outcomes of patients with COVID-19	Peng,  ZH,  Chen, et al	Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Establish a new model for the prediction of severe outcomes of COVID-19 patients and provide more comprehensive, accurate and timely indicators for the early identification of severe COVID-19 patients. The prediction sensitivity of the model based on the training set was 61.7%, and the missed diagnosis rate was 38.3%. The prediction sensitivity of the model based on the test set was 75.0%, and the missed diagnosis rate was 25.0%.
Change in Youth Mental Health During the COVID-19 Pandemic in a Majority Hispanic/Latinx US Sample	Penner,  F,  Ortiz, et al	J Am Acad Child Adolesc Psychiatry	Mental Health | santé mentale	Examined change in mental health from before to during the pandemic among predominantly Hispanic/Latinx adolescents. For youth who had elevated levels of mental health problems pre-pandemic, symptoms were significantly reduced across domains during the pandemic. Reductions in internalizing, externalizing, and total problems were clinically significant. For other youth, there were statistically significant reductions in internalizing and total problems, and no change in attention or externalizing problems. Post-hoc analyses revealed that better family functioning was consistently related to lower mental health symptoms in youth during COVID-19 follow-ups
Childhood B-Cell Acute Lymphoblastic Leukemia Following SARS CoV-2 Infection: A Potential Second "Hit" in Leukemogenesis	Persaud,  Y,  Shamoun, et al	J Pediatr Hematol Oncol	Clinical data| Données cliniques	Present a case of a child who developed B-cell acute lymphoblastic leukemia 1 week following a symptomatic COVID-19 infection.
Reversibility of venous dilatation and parenchymal changes density in Sars-Cov-2 pneumonia: toward the definition of a peculiar pattern	Piciucchi,  S,  Ravaglia, et al	Pulmonology	Clinical data| Données cliniques	Describe CT findings of five patients affected by COVD-19 in the early phase of the disease emphasizing the vascular and alveolar changes modified by gravity.
Field performance and public health response using the BinaxNOW TM Rapid SARS-CoV-2 antigen detection assay during community-based testing	Pilarowski,  G,  Marquez, et al	Clin Infect Dis	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Among 3,302 persons tested for SARS-CoV-2 by BinaxNOW TM and RT-PCR in a community setting, rapid assay sensitivity was 100%/98.5%/89% using RT-PCR Ct thresholds of 30, 35 and none. The specificity was 99.9%. Performance was high across ages and those with and without symptoms. Rapid resulting permitted immediate public health action.
The effects of transition to technician-delivered telehealth ABA treatment during the COVID-19 crisis: A preliminary analysis	Pollard,  JS,  LeBlanc, et al	J Appl Behav Anal	Healthcare Response | Réponse des soins de santé	Describe a sample of 17 cases that transitioned from in‐person to telehealth delivery of treatment when shelter‐in‐place orders were issued. Of these cases, 76% of participants transitioned to technician‐delivered telehealth services whereas the rest transitioned to a caregiver‐implemented telehealth model. Participants continued to access a similar dosage of treatment hours per week in spite of the treatment model transition (in‐person N = 12; telehealth N = 11) and maintained or improved correct independent responding across all targets from in‐person treatment to telehealth treatment. These findings provide initial evidence that some clients with autism benefit from technician‐delivered telehealth services.
SARS-CoV-2 disease severity and transmission efficiency is increased for airborne but not fomite exposure in Syrian hamsters	Port,  JuliaR,  Yinda, et al	bioRxiv	Transmission Animal model | Modèle animal	Demonstrate Syrian hamsters are susceptible to SARS-CoV-2 infection through intranasal, aerosol and fomite exposure. Fomite exposure led to milder disease manifestation characterized by an anti-inflammatory immune state and delayed shedding pattern. Early shedding was linked to an increase in disease severity. Airborne transmission was more efficient than fomite transmission and dependent on the direction of the airflow.
Anxiety and Suicidal Thoughts During the COVID-19 Pandemic: Cross-Country Comparative Study Among Indonesian, Taiwanese, and Thai University Students	Pramukti,  I,  Strong, et al	J Med Internet Res	Mental Health | santé mentale	Study examined the psychological responses toward COVID-19 among university students from 3 countries—Indonesia, Taiwan, and Thailand. Thai students had the highest levels of anxiety but the lowest levels of confidence in pandemic control and available resources for fighting COVID-19. Factors associated with higher anxiety differed across countries. Less perceived satisfactory support was associated with more suicidal thoughts among Indonesian students. Taiwanese students were more negatively affected by information gathered from the internet and from medical staff than were Indonesian or Thai students.
Intention to receive a vaccine against SARS-CoV-2 in Italy and its association with trust, worry and beliefs about the origin of the virus	Prati,  G	Health Educ Res	Public Health response| Interventions de santé publique	Most respondents (75.8%) intended to receive a vaccine, while 32 (5.1%) and 63 (10.1%) participants responded ‘No’ and ‘I do not know’, respectively. The remaining participants (9.0%) chose not to respond to this question. Controlling for socio-demographic factors, a multinomial logistic regression model revealed that no intention to receive a vaccine was associated with lower levels of worry and institutional trust, while increased odds for responding ‘do not know’ were found among participants holding beliefs about the non-natural origin of the virus. Vaccine acceptance may not be sufficient to establish a high level of herd immunity and a successful implementation of new pandemic vaccination programs should take into account trust, conspiracy beliefs and worry.
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition	Prelli Bozzo,  Caterina,  Nchioua, et al	bioRxiv	Coronavirology| Coronavirologie	Results indicate that the SARS-CoV-2 Spike protein interacts with IFITMs and hijacks them for efficient viral entry. IFITM proteins were expressed and further induced by interferons in human lung, gut, heart and brain cells. Intriguingly, IFITM-derived peptides and targeting antibodies inhibited SARS-CoV-2 entry and replication in human lung cells, cardiomyocytes and gut organoids. Results show that IFITM proteins are important cofactors for SARS-CoV-2 infection of human cell types representing in vivo targets for viral transmission, dissemination and pathogenesis and suitable targets for therapeutic approaches.
Detection and molecular characterisation of SARS-CoV-2 in farmed mink (Neovision vision) in Poland	Rabalski,  Lukasz,  Kosinski, et al	bioRxiv	zoonoses	Here we investigated 91 individual minks from a farm located in Northern Poland. Using RT-PCR, antigen detection and NGS, we confirmed 15 animals positive for SARS-CoV-2. The result was verified by sequencing of full viral genomes, confirming SARS-CoV-2 infection in Polish mink. Country-scale monitoring conducted by veterinary inspection so far has not detected the presence of SARS-CoV-2 on other mink farms. Taking into consideration that Poland has a high level of positive diagnostic tests among its population, there is a high risk that more Polish mink farms become a source for SARS-CoV-2
COVID-19 pneumonia in a patient with sarcoidosis: A case report	Ramdani,  H,  Benelhosni, et al	Clinical Case Reports	Clinical data| Données cliniques	We report the case of a patient with sarcoidosis who contracted Sars‐Cov 2 as limited data is available regarding this association and there is concern about its poor outcome. Key elements to consider are sarcoidosis pulmonary involvement, the underlying immune system dysfunction, the immunosuppressants’ use, and the increased hypercoagulability risk.
SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity	Ramirez,  Carlos,  Kumar Sharma, et al	bioRxiv	Coronavirology| Coronavirologie	Here, we explored the existence of a co-regulation between SPINT2/TMPRSS2 and found a tightly regulated protease/inhibitor expression balance across tissues. We found that SPINT2 negatively correlates with SARS-CoV-2 expression in Calu-3 and Caco-2 cell lines and was down-regulated in secretory cells from COVID-19 patients. We validated our findings using Calu-3 cell lines and observed a strong increase in viral load after SPINT2 knockdown. Additionally, we evaluated the expression of SPINT2 in datasets from comorbid diseases using bulk and scRNA-seq data.
Incidence of Suspected Serious Adverse Drug Reactions in Corona Virus Disease-19 Patients Detected by a Pharmacovigilance Program by Laboratory Signals in a Tertiary Hospital in Spain: Cautionary Data	Ramírez,  E,  Urroz, et al	Frontiers in Pharmacology	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim of this study is to report the suspected serious adverse drug reactions (SADRs) in COVID-19 patients vs. non-COVID-19 patients in Spain detected by the prospective pharmacovigilance program based on automatic laboratory signals (ALSs) in the hospital (PPLSH) during that period. We also compared the results with the suspected SADRs detected during the same period for 2019. The incidence rate of SADRs detected in the COVID-19 patients was 760.63 (95% CI 707.89–816.01) per 10,000 patients, 4.75-fold higher than the SADR rate for non-COVID-19 patients (160.15 per 10,000 patients, 95% CI 137.09–186.80), and 5.84-fold higher than the SADR rate detected for the same period in 2019 (130.19 per 10,000 patients, 95% CI 109.53–154.36). The most frequently related drugs were tocilizumab (59.84%), dexketoprofen (13.93%), azithromycin (8.43%), lopinavir-ritonavir (7.35%), dexamethasone (7.62%), and chloroquine/hydroxychloroquine (6.91%).
Unraveling the SARS-CoV-2 Main Protease Mechanism Using Multiscale Methods	Ramos-Guzmán,  CA,  Ruiz-Pernía, et al	ACS Catalysis	Coronavirology| Coronavirologie	We present a detailed theoretical analysis of the reaction mechanism of proteolysis catalyzed by the main protease of SARS-CoV-2. Using multiscale simulation methods, we have characterized the interactions established by a peptidic substrate in the active site, and then we have explored the free energy landscape associated with the acylation and deacylation steps of the proteolysis reaction, characterizing the transition states of the process. Our mechanistic proposals can explain most of the experimental observations made on the highly similar ortholog protease of SARS-CoV.
Association between prior cardiometabolic therapy and in-hospital mortality in very old patients with type 2 diabetes mellitus hospitalized due to COVID-19. A nationwide observational study in Spain	Ramos-Rincón,  Jose Manuel,  Pérez-Belmonte, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques	This work aims to analyze the association between preadmission cardiometabolic therapy (antidiabetic, antiaggregant, antihypertensive, and lipid-lowering drugs) and in-hospital mortality among patients ≥ 80 years with type 2 diabetes mellitus hospitalized for COVID-19 in Spain. On the multivariate analysis, the use of dipeptidyl peptidase-4 inhibitors (AOR 0.502, 95% CI 0.309–0.815, p = 0.005) and angiotensin receptor blockers (AOR 0.454, 95% CI 0.274–0.759, p = 0.003) were independent protectors against in-hospital mortality whereas the use of acetylsalicylic acid was associated with higher in-hospital mortality (AOR 1.761, 95% CI 1.092–2.842, p = 0.020). Other antidiabetic drugs, angiotensin-converting enzyme inhibitors and statins showed neutral association with in-hospital mortality. The model showed an area under the curve of 0.788.
Small-sample estimation of the mutational support and the distribution of mutations in the SARS-Cov-2 genome	Rana,  Vishal,  Chien, et al	medRxiv	Epidemiology| Épidémiologie Coronavirology| Coronavirologie	To estimate the mutational support in the small-sample regime, we use GISAID sequencing data and new state-of-the-art polynomial estimation techniques based on weighted and regularized Chebyshev approximations. For distribution estimation, we adapt the well-known Good-Turing estimator. We also perform a differential analysis of mutations and their sites across different populations. Our analysis reveals several findings: First, the mutational supports exhibit significant differences in the ORF6 and ORF7a regions (older vs younger patients), ORF1b and ORF10 regions (females vs males) and as may be expected, in almost all ORFs (for Asia versus Europe and North America). Second, despite the fact that the N region of SARS-Cov-2 has a predicted 10% mutational support, almost all observed mutations fall outside of the two regions of paired primers recommended for testing by the CDC.
Multivariate time series approximation by multiple trajectories of a dynamical system. Applications to internet traffic and COVID-19 data	Rayskin,  V		Epidemiology| Épidémiologie	Utilization of multiple trajectories of a dynamical system model provides us with several benefits in approximation of time series. For short term predictions a high accuracy can be achieved via switches to new trajectory at any time. In this paper one example uses COVID-19 data. We study the dynamics of the cases (confirmed infections, recoveries and deaths) of all significantly affected countries. In this preliminary study we minimize the total error of all countries’ next day prediction.
Chronic rhinosinusitis is associated with prolonged SARS-CoV2 RNA shedding in upper respiratory tract samples: A case-control study	Recalde-Zamacona,  B,  Tomás-Velázquez, et al	J Intern Med	Clinical data| Données cliniques	The aim of this case control study was to determine risk factors for prolonged viral shedding (a positive RT-PCR  result  for  more  than  28  days) among patient’s basal clinical conditions. Global median duration of viral clearance was 25.5 days (n=54; IQR, 22–39.3 days), 48.5 days in cases (IQR 38.7‐54.9 days) and 23 days in controls (IQR 20.2‐25.7), respectively. There were not observed differences in demographic, symptoms or treatment data between groups. Multivariate analysis indicated that Chronic rhino sinusitis (CRS) (odds ratio [OR], 18.78; 95% confidence interval [95%CI],3.89 – 90.59; p<0.001) was independently associated with prolonged SARS‐CoV‐2 RNA shedding in URT samples, after adjusting for initial PCR Ct values.
Young Hispanic fathers during COVID-19: Balancing parenthood, finding strength, and maintaining hope	Recto,  P,  Lesser, et al	Public Health Nurs	Mental Health | santé mentale	This study examined how the effects of the COVID‐19 crisis has impacted young Hispanic fathers. The participants’ initial and ongoing fears about COVID‐19 resulted from not having adequate information about the severity of the disease and how easily one can contract and transmit it to others. They also expressed concerns about the threat of the pandemic on their family's well‐being, finances, and employment status. Providing for their families was their main priority, with some continuing to work, despite the risks of becoming infected with COVID‐19. Despite their many hardships, fathers found strength in their families and remained hopeful in overcoming the challenges during the pandemic.
Repurposing of renin inhibitors as SARS-COV-2 main protease inhibitors: A computational study	Refaey,  RH,  El-Ashrey, et al	Virology	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	In the present work pharmacophore elucidation is a powerful tool to explore the essential binding interactions with SARS-COV-2 main protease enzyme, this was performed through a ligand-based approach depending on the structure of the inhibitors that were crystallized with this enzyme and released in protein data bank. Virtual screening was performed using a database of 84 released co-crystallized renin inhibitors, the hits were filtered relying on Lipinski's drug-like filter and a docking study was then carried out to confirm the results.  Molecular docking for both compounds showed that the orally active renin inhibitor remikiren (Ro 42–5892) of Hoffmann–La Roche exhibited good molecular interaction with Cys145 and His41 in the catalytic site of SARS-CoV-2 main protease.
Eruptions and Related Clinical Course Among 296 Hospitalized Adults with Confirmed COVID-19	Rekhtman,  S,  Tannenbaum, et al	J Am Acad Dermatol	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objective of this study was to estimate prevalence of mucocutaneous findings, characterize morphologic patterns, and describe relationship to course in hospitalized adults with COVID-19. Among 296 hospitalized adults with COVID-19, 35 (11.8%) had at least one disease-related eruption. Patterns included ulcer (13/35, 37.1%), purpura (9/35, 25.7%), necrosis (5/35, 14.3%), non-specific erythema (4/35, 11.4%), morbilliform eruption (4/35, 11.4%), pernio-like lesions (4/35, 11.4%), and vesicles (1/35, 2.9%). Patients with mucocutaneous disease were more likely to use mechanical ventilation [adjusted PR 1.98 (1.37-2.86); P<0.001]. Differences for other outcomes were attenuated after covariate adjustment and did not reach statistical significance.
Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression	Rendeiro,  AF,  Casano, et al	Life Sci Alliance	Clinical data| Données cliniques Immunology | Immunologie	We performed longitudinal immune profiling of peripheral blood mononuclear cells from 45 patients and healthy donors. We observed a dynamic immune landscape of innate and adaptive immune cells in disease progression and absolute changes of lymphocyte and myeloid cells in severe versus mild cases or healthy controls. Intubation and death were coupled with selected natural killer cell KIR receptor usage and IgM+ B cells and associated with profound CD4 and CD8 T-cell exhaustion. Pseudo-temporal reconstruction of the hierarchy of disease progression revealed dynamic time changes in the global population recapitulating individual patients and the development of an eight-marker classifier of disease severity.
Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection	Reynolds,  CJ,  Swadling, et al	Sci Immunol	Clinical data| Données cliniques Immunology | Immunologie	We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. T cell responses tended to be lower following asymptomatic infection than in those reporting case-definition symptoms of COVID-19, while nAb titers were maintained irrespective of symptoms. T cell and antibody responses were sometimes discordant. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection.
Preliminary experiences in acute occupational therapy for in-patients with coronavirus-19 (COVID-19): leveraging assistive technology in three case studies of male veterans	Rich,  T,  Hicks, et al	Disabil Rehabil Assist Technol	Clinical data| Données cliniques	The purpose of this case series is to describe occupational therapy (OT) and special technology considerations for three male Veteran patients hospitalised with suspected or confirmed COVID-19. In two of three of our cases, we describe acute rehabilitation with a focus on activity tolerance, participation in occupations, and discharge planning. In all cases, we measured vital signs and activity tolerance as primary outcomes. The findings suggest that outcome measures focussing on activity tolerance to maintain stable vital signs during the recovery phase is central to the progression of activities. We observed in our cases that the Person-Environment-Occupation-Performance (PEOP) model can guide practice and complement the medical model in management of these patients.
Analysis of Nationwide Stroke Patient Care in Times of COVID-19 Pandemic in Germany	Richter,  D,  Eyding, et al	Stroke	Healthcare Response | Réponse des soins de santé	We conducted a nationwide cohort study using administrative database of all hospitalized patients with main diagnosis of acute ischemic stroke (AIS), transient ischemic attack, or intracerebral hemorrhage in Germany to compare case numbers and treatment characteristics of the pandemic and prepandemic periods. Results overall indicate a massive decrease in absolute case numbers, our data suggest that patients with AIS who did seek acute care during the pandemic, continued to receive acute recanalization treatment in Germany.
Simple predictive models identify patients with COVID-19 pneumonia and poor prognosis	Riveiro-Barciela,  M,  Labrador-Horrillo, et al	PLoS One	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	We aimed to establish predictive models for COVID-19 pneumonia severity in hospitalized patients by retrospectively studying 430 patients admitted in Vall d’Hebron Hospital (Barcelona). The baseline predictive model showed a ROC of 0.800 based on: SpO2/FiO2 (adjusted Hazard Ratio-aHR = 8), chest x-ray (aHR = 4), prior immunosuppressive therapy (aHR = 4), obesity (aHR = 2), IL-6 (aHR = 2), platelets (aHR = 0.5). The cut-off of 11 presented a specificity of 94.8%.
The Impact of the Covid-19 Epidemic on Older Adults in Rural and Urban Areas in Mexico	Rivera-Hernandez,  M,  Ferdows, et al	J Gerontol B Psychol Sci Soc Sci	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objectives of the article were to compare clinical and demographic characteristics for people diagnosed with COVID-19 by age group, and to describe cases and mortality in rural and urban communities. Older adults were found to be more likely to be hospitalized and reported severe cases, with higher mortality rates. In addition, rural municipalities reported a higher number of COVID-19 cases and mortality related to COVID-19 per million than urban municipalities. The adjusted absolute difference in COVID-19 cases was 912.7 per million (95% Confidence Interval (CI),79.0 – 1746.4) and mortality related to COVID-19 was 390.6 per million (95% CI, 204.5 – 576.7).
PMC7322984; The dramatic COVID 19 outbreak in Italy is responsible of a huge drop of urological surgical activity: a multicenter observational study	Rocco,  B,  Sighinolfi, et al	BJU Int	Healthcare Response | Réponse des soins de santé	The objective of this study was to describe the trend in surgical volume in urology in Italy during the coronavirus disease 2019 (COVID‐19) outbreak in 33 urological units. Before the outbreak, the involved urology units performed overall 1213 procedures/week, half of which were oncological. A month later, the number of surgeries had declined by 78%. Lombardy, the first region with positive COVID‐19 cases, experienced a 94% reduction. The decrease in oncological and non‐oncological surgical activity was 35.9% and 89%, respectively. The trend of the decline showed a delay of roughly 2 weeks for the other regions.
Early use of nitazoxanide in mild Covid-19 disease: randomised, placebo-controlled trial	Rocco,  PRM,  Silva, et al	Eur Respir J	Therapeutics| Thérapeutique RCT	In a multicenter, randomised, double-blind, placebo-controlled trial, adult patients presenting up to 3 days after onset of Covid-19 symptoms were placed into a either nitazoxanide (500 mg), placebo, or TID group. In patients with mild Covid-19, symptom resolution did not differ between nitazoxanide and placebo groups after 5 days of therapy. However, early nitazoxanide therapy was safe and reduced viral load significantly.
New coronavirus infection as trigger factor for multisystem inflammatory syndrome in children: Literature review and analysis of original data	Rodionovskaya,  SR,  Mazankova, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Clinical data| Données cliniques	This paper presents a literature review and case data of children with MIS-C with the aim of identifying clinical manifestations and results of laboratory and instrumental examination of pediatric patients with confirmed MIS-C caused by a new coronavirus infection, the most characteristic features of this pathology and to analyze the amount of therapy based on the assessment of epidemiological data.
An immunomodulatory peptide CIGB-258 for the treatment of critical and severe COVID-19 patients	Rodríguez,  RV,  Ruiz, et al	Revista Cubana de Medicina Militar	Therapeutics| Thérapeutique	The aim of this study is to establish the dose frequency and time of treatment with the CIGB-258 peptide, for critical patients with COVID-19. In addition, define the criteria for use and the therapeutic scheme of the peptide, for seriously ill patients with COVID-19. 9 critical patients and 3 seriously ill patients were included. The clinical, radiological and laboratory evaluations were recorded according to the established protocol. The action protocol was established with the CIGB-258 peptide, which consists of the intravenous administration of 1 mg of the peptide every 12 hours to critical patients. The dose should be increased to 2 mg every 12 hours, for patients who do not show clinical and radiological improvement in 24 hours. After extubation, patients should receive 1 mg of CIGB-258 daily for another three days. Critically ill patients should receive 1 mg of CIGB-258 every 12 hours, until their clinical condition resolves.
PMC7745306; Experiences of young adults with a history of foster care during COVID-19	Ruff,  SC,  Linville, et al	Child Youth Serv Rev	Mental Health | santé mentale	This study assessed the needs, concerns, and strengths of young adults (ages 18–26), previously placed in foster care, in response to coronavirus disease 2019  (n=127).  Participants reported significant increases in their level of concern regarding physical, financial, professional, social, relational, and psychological levels of concern before Shelter in Place (SIP) orders to during SIP, which was maintained in anticipation of the year following SIP.
Estimation of Years of Life Lost by Sweden's Relaxed COVID-19 Mitigation Strategy	Rypdal,  Martin,  Rypdal, et al	Research Square prepub	Epidemiology| Épidémiologie	The objective of this study was to estimate the weekly excess all-cause mortality in Norway and Sweden, and to estimate the years of life lost (YLL) attributed to COVID-19 in Sweden and the significance of mortality displacement. We found that excess all-cause mortality over the epidemic year (July to July) 2019/20 was 517 (95%CI -12, 1074) in Norway and 4329 (3331, 5325) in Sweden. There were reported 255 COVID-19 related deaths in Norway, and 5741 in Sweden, that year. During the epidemic period March 11 – November 11, there were 6247 reported COVID-19 deaths and 5517 (4701, 6330) excess deaths in Sweden. The estimated number of life-years lost attributed to the more relaxed Swedish strategy was 45850 (13915, 80276) without adjusting for mortality displacement and 43073 (12160, 85451) after adjusting for possible displacement.
PMC7752710; EMCNet: Automated COVID-19 diagnosis from X-ray images using convolutional neural network and ensemble of machine learning classifiers	Saha,  P,  Sadi, et al	Inform Med Unlocked	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In this paper, an automated detection scheme named EMCNet was proposed to identify COVID-19 patients by evaluating chest X-ray images. A convolutional neural network was developed focusing on the simplicity of the model to extract deep and high-level features from X-ray images of patients infected with COVID-19. With the extracted features, binary machine learning classifiers (random forest, support vector machine, decision tree, and AdaBoost) were developed for the detection of COVID-19. In comparison with other recent deep learning-based systems, EMCNet showed better performance with 98.91% accuracy, 100% precision, 97.82% recall, and 98.89% F1-score.
No clinical benefit in mortality associated with hydroxychloroquine treatment in patients with COVID-19	Sands,  K,  Wenzel, et al	Int J Infect Dis	Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique	The purpose of this retrospective study was to determine whether HCQ administration is associated with improved mortality in COVID-19 patients. A total of 1669 patients were evaluated (no HCQ, n = 696; HCQ, n = 973). When adjusting for patient characteristics, receipt of AZM, and severity of disease at admission, there was no beneficial effect on the odds of death associated with receipt of HCQ. In this population, there was an 81% increase in the odds of mortality among patients who received HCQ at any time during their encounter versus with no HCQ exposure (OR: 1.81, 95% CI: 1.20-2.77, p = 0.01).
A multidisciplinary registry of patients with autoimmune and immune-mediated diseases with symptomatic COVID-19 from a single center	Sarmiento-Monroy,  J,  Espinosa, et al	Journal of Autoimmunity	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim was to describe a multidisciplinary cohort of patients with autoimmune and immune-mediated inflammatory diseases (AI/IMID) and symptomatic SARS-CoV-2 infection in a single tertiary center and analyze sociodemographic, clinical, and therapeutic factors associated with poor outcomes. A retrospective observational study was conducted from the 1st of March until May 29th, 2020 in a University tertiary hospital in Barcelona, Spain. In logistic regression analysis, a significant inverse association between AI/IMID group and severe SARS-CoV-2 (OR 0.28; 95% CI 0.12–0.61; p = 0.001), need of MV (OR 0.20; IC 95% 0.05–0.71; p = 0.014), and ICU admission (OR 0.25; IC 95% 0.10–0.62; p = 0.003) was found.
Evidence-based of conjunctival COVID-19 positivity: An Italian experience: Gemelli Against COVID Group	Savastano,  MC,  Gambini, et al	Eur J Ophthalmol	Clinical data| Données cliniques	The main goal of our study was to investigate the positivity of the COVID-19 in the conjunctival mucosa, in order to evaluate a possible new diagnostic tool. The secondary goal was the correlation between the conjunctival positivity and the disease-related systemic impairment. Ocular signs (conjunctivitis) were present in five patients (10%). nasopharyngeal swab (NPs) and conjunctival swabs (Cs) highlighted a poor level of agreement (0.025; p = 0.404). Intensive care unit patients showed higher COVID-19 Cs positivity in conjunctiva (12.5%) against hospitalized ones (5.8%).
Characterizing the COVID-19 Transmission in South Korea Using the KCDC Patient Data	Schmedding,  Anna,  Yang, et al	ArXiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	In this paper, we analyze patient and route data of infected patients from January 20, 2020, to May 31, 2020, collected by the Korean Center for Disease Control & Prevention (KCDC) in order to characterize patient mobility patterns. We then use this characterization to parameterize simulations to evaluate different what-if  spreading scenarios.
A SARS-CoV-2 spike binding DNA aptamer that inhibits pseudovirus infection in vitro by an RBD independent mechanism	Schmitz,  Anton,  Weber, et al	bioRxiv	Coronavirology| Coronavirologie	We used an automated selection process and identified an aptamer that specifically interacts with CoV2-S. The aptamer does not bind to the RBD of CoV2-S and does not block the interaction of CoV2-S with ACE2. The aptamer inhibits viral infection, exemplified by employing a CoV2-S pseudotyped virus and an ACE2 expressing cell line. These findings demonstrate that viral infection can be inhibited independent of targeting RBD and suggest that inhibition could be possible despite the virus has already bound to cells. The results open the path to inhibitors of SARS-CoV-2 infection with hitherto inaccessible modes of action
The Impact of the COVID-19 Pandemic on Incidences of Atrial Fibrillation and Electrical Cardioversion at a Tertiary Care Emergency Department: An Inter- and Intra-year Analysis	Schnaubelt,  S,  Domanovits, et al	Frontiers in Medicine	Healthcare Response | Réponse des soins de santé	We aimed at validating the reports from a Viennese tertiary care Emergency Department (ED) regarding the dynamics in the ED workload concerning atrial fibrillation (AF,) and clarifying if the need for interventions such as electrical cardioversion (eCV) follows the hypothesized decreased AF incidences. Results indicate that there was no significant incidence differences in inter-year analyses of the time periods from January to May, or of the weeks pre- and post the national lockdown due to the COVID-19 pandemic. However, the intra-year analysis of the year 2020 showed a trend toward decreased atrial fibrillation incidences (rate-ratio 0.982, CI 0.964–1.001, p = 0.060), and significantly increased electrical cardioversion incidences in the post-lockdown period (rate ratio 1.051, CI 1.008–10.96, p = 0.020).
Severe Acute Respiratory Syndrome Coronavirus 2 Placental Infection and Inflammation Leading to Fetal Distress and Neonatal Multi-Organ Failure in an Asymptomatic Woman	Schoenmakers,  S,  Snijder, et al	J Pediatric Infect Dis Soc	Clinical data| Données cliniques	Case report of a 30-year-old obese primigravid woman with gestational diabetes was referred to our tertiary center at 31 + 4 weeks’ gestation due to lack of fetal movements during the last 2 days. RT-qPCRs of the oropharynx, maternal blood, vagina, placenta, and urine were all positive over a period of 6 days, while breast milk, feces, and all neonatal samples tested negative. Placental findings showed the presence of SARS-CoV-2 particles with generalized inflammation characterized by histiocytic intervillositis with diffuse perivillous fibrin depositions with damage to the syncytiotrophoblasts.
[Characteristics and outcome of 70 ventilated COVID-19 patients : Summary after the first wave at a university center]	Schroeder,  I,  Scharf, et al	Anaesthesist	Epidemiology| Épidémiologie	The aim of this study as to compare patient data from the LMU intensive care unit (ICU) patients and national published German data. The overall in-hospital mortality rate of ICU patients requiring ventilation was 28.6%. The mortality rates of patients from external hospitals, patients with renal replacement therapy and patients with ECMO therapy were 47.4%, 56.7% and 85.7%, respectively.
Epidemiology, clinical characteristics, household transmission, and lethality of severe acute respiratory syndrome coronavirus-2 infection among healthcare workers in Ontario, Canada	Schwartz,  KL,  Achonu, et al	PLoS One	Epidemiology| Épidémiologie Clinical data| Données cliniques	Our objective was to describe and compare the epidemiology, clinical characteristics, and lethality of SARS-CoV-2 infections among HCWs compared to non-HCWs in Ontario. There were 7,050 (12.5%) HCW SARS-CoV-2 infections in Ontario, Canada, of whom 24.9% were nurses, 2.3% were physicians, and the remaining 72.8% other specialties, including personal support workers. Overall HCWs had an infection rate of 1,276 per 100,000 compared to non-HCWs of 346 per 100,000 (3.7 times higher). This difference decreased from a 7 times higher rate in April to no difference in September 2020. Twenty-six percent of HCWs had a household member with SARS-CoV-2 infection; 6.8% were probable acquisitions, 12.3% secondary transmissions, and 6.9% unknown direction of transmission. Death among HCWs was 0.2% compared to 6.1% of non-HCWs. The risk of death in HCWs remained significantly lower than non-HCWs after adjustment (adjusted odds ratio 0.09; 95%CI 0.05–0.17).
PMC7709811; Obsessive compulsive symptoms severity among children and adolescents during COVID-19 first wave in Israel	Schwartz-Lifshitz,  M,  Basel, et al	J Obsessive Compuls Relat Disord	Mental Health | santé mentale	The purpose of this study was to evaluate whether OCD exacerbated during the first wave of COVID-19 in children and adolescents. Twenty-nine children and adolescents with OCD were evaluated in the midst of the first outbreak of the COVID-19 pandemic in Israel (April–May 2020). Obsessive-compulsive symptoms were not found to have exacerbated during the period investigated, as evident by a lack of change in Global Impression Scale (CGI) severity scores and by improvement rather than deterioration among more participants, based on the CGI improvement scores. Additionally, the children and adolescents reported better general functioning during the COVID-19 period and had relatively low scores on the Obsessive-Compulsive Inventory-child version (OCI-CV) scale.
Optimal strategies for control of COVID-19: A mathematical perspective	Seidu,  B	Scientifica	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	A deterministic ordinary differential equation model for SARS-CoV-2 is developed and analysed, taking into account the role of exposed, mildly symptomatic, and severely symptomatic persons in the spread of the disease. In the absence of immigration of infective persons, the disease can be eradicated whenever . Specifically, if the controls , are implemented to 100% efficiency, the disease dies away easily. It is shown that border closure (or at least screening) is indispensable in the fight against the spread of SARS-CoV-2. Simulation of optimal control of the model suggests that the most cost-effective strategy to combat SARS-CoV-2 is to reduce contact through use of nose masks and physical distancing.
Anticipating the Need for Healthcare Resources Following the Escalation of the COVID-19 Outbreak in the Republic of Kazakhstan	Semenova,  Y,  Pivina, et al	Journal of preventive medicine and public health = Yebang Uihakhoe chi	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	This stud following the expansion of the coronavirus disease 2019 (COVID-19) outbreak in the Republic of Kazakhstan, focusing on hospital beds, equipment, and the professional workforce in light of the developing epidemiological situation and the data on resources currently available. Over the forecast period, there will be 104 713.7 hospital admissions due to severe disease and 34 904.5 hospital admissions due to critical disease. This will require 47 247.7 beds for severe disease and 1929.9 beds for critical disease at the peak of the COVID-19 outbreak.
Comparison of Critical Care Occupancy and Outcomes of Critically ill Patients during the 2020 COVID-19 Winter Surge and 2009 H1N1 Influenza Pandemic in Australia	Serpa Neto,  A,  Burrell, et al	Ann Am Thorac Soc	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objective of this study is to report and compare the demographic characteristics, treatments, use of critical care resources, and outcomes of patients admitted to an Australian ICU with H1N1 influenza during the winter of 2009, and SARS–CoV–2, during the winter of 2020.  Across the two epochs, 861 patients were admitted to ICUs; 236 (27.4%) with COVID–19, and 625 (72.6%) with H1N1 influenza. The number of ICU admissions and bed-days occupied were higher with 2009 H1N1 influenza. Unadjusted in–hospital mortality was similar (11.5% in COVID–19 vs. 16.1% in H1N1; odds ratio, 0.68 [95% confidence interval, 0.42 to 1.06]; p = 0.10). The Potential years of life lost (PYLL)  was greater with H1N1 influenza than with COVID–19 at 154.1 (95% CI, 148.7 to 159.4) vs 13.6 (95% CI, 12.2 to 15.1) PYLL per million inhabitants.
PMC7651837; Impact of socioeconomic status in patients hospitalised for COVID-19 in the Greater Paris area	Sesé,  L,  Nguyen, et al	Eur Respir J	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study report on the influence of socio-economic status on the mortality from SARS-CoV-2 in the greater Paris area. On multivariate analysis, age and EPICES (Evaluation of Health Inequalities for Health Insurance Health Examination Centre) score were independently associated to an increased risk of initial severity, with an odds ratio of 1.099 (95% CI 1.038–1.178; p=0.003), and 1.029 (95% CI 1.003–1.059; p=0.033) per EPICES score point, respectively.
Outcome of Covid-19 Positive Newborns Presenting to a Tertiary Care Hospital	Shah,  B,  Dande, et al	Indian Pediatr	Clinical data| Données cliniques	The study reports on of all out-born neonates presenting for admission to the NICU from April 1 to August 31 in a hospital in India. Of the 423 outborn neonates; 18 (4.25%) tested positive for SARS-CoV-2 by RT-PCR of nasopharyngeal swabs. Four babies were preterms (youngest weighing 1000 g), and 9 were delivered by caesarian section, with the most common indication being meconium stained liquor. All positive neonates had symptoms warranting neonatal intensive care unit (NICU) admission. Clinical presentation was varied, with respiratory distress being the most common, which could be attributed to neonatal respiratory or cardiac problems. Six babies required ventilation.
Fractal-Fractional Mathematical Model Addressing the Situation of Corona Virus in Pakistan	Shah,  K,  Arfan, et al	Results in Physics	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	This work is the consideration of a fractal fractional mathematical model on the transmission and control of corona virus (COVID-19) in Pakistan, in which the total population of an infected area is divided into susceptible, infected and recovered classes. We consider a fractal-fractional order SIR type model for investigation of Covid-19. To realize the transmission and control of corona virus in a much better way, first we study the stability of the corresponding deterministic model using next generation matrix along with basic reproduction number.
The Mental Health Impact of COVID-19 Outbreak: A Nationwide Survey in Iran	Shahriarirad,  Reza,  Erfani, et al	Research Square prepub	Mental Health | santé mentale	This cross-sectional web survey study aims to explore and evaluate the burden of psychological problems on the Iranian general population during the outbreak of COVID-19 (n=8591). Based on our results, 1295 (15.1%) and 1733 (20.1%) of the general population clinically significant depressive and anxiety symptoms respectively. Based on the demographic variables, female gender was associated with a higher risk for developing depression and anxiety symptoms, whereas getting information about the disease from medical journals and articles, being older, and being married were considered as associated protective factors. In terms of depression, being a healthcare worker was an associated risk factor.
In-Silico Comparative Analysis of Egyptian SARS CoV-2 with Other Populations: A Phylogeny and Mutation Analysis	Sharawy,  L,  Tantawy, et al		Epidemiology| Épidémiologie Coronavirology| Coronavirologie	In this study, we investigate how the viral genetic code mutated locally and what variations is the Egyptian population most susceptible to in comparison with different strains isolated from Asia, Europe and other countries in Africa. Our aim is to evaluate the significance of these variations and whether they constitute a change on the protein level and identify if any of these variations occurred in the conserved domain of the virus. When the mutations were evaluated, Spike_D614G, NSP12_P323L, NS3_Q57H and N_R203K were found to be the most common amino acid substitutions among the viral isolates from Egypt. All retrieved mutations were processed and analyzed with principal component analysis (PCA). In general, no clear clusters were clustered based on the mutation pattern of different continents, including Africa, Asia, and Europe.
Phylogenetic and whole genome analysis of first seven SARS-CoV-2 isolates in Bangladesh	Sharif,  N,  Dey, et al	Future Virology	Epidemiology| Épidémiologie Coronavirology| Coronavirologie	We report whole genome and peptide mutations of the first the first seven whole genomes of SARS-CoV-2 in Bangladesh. 100% of isolates in Bangladesh were in the G clade. We found 99.98–100% sequence similarity among Bangladeshi isolates and isolates of England, Greece, USA, Saudi Arabia and India. Deletion of bases at 5′ untranslated region and 3′ untranslated region was detected. Substitution 261 (E→D) at NSP13 and 1109 (F→L) at spike (S) protein were detected. Substitution 377 (D→G) at nucleocapsid with common substitution 614 (D→G) at S were also detected.
On the molecular structure of Remdesivir for the treatment of Covid-19	Sheikholeslami,  SM,  Jahanbani, et al	Comput Methods Biomech Biomed Engin	Therapeutics| Thérapeutique	In this paper, we compute some of the general temperature topological properties of remdesivir that the results in this paper may be useful in finding new drug and vaccine for the treatment and prevention of COVID-19.
Estimated Impact of Public and Private Sector COVID-19 Diagnostics and Treatments on US Healthcare Resource Utilization	Sheinson,  DM,  Wong, et al	Adv Ther	Epidemiology| Épidémiologie	We modeled the impact of public and private sector contributions to developing diagnostic testing and treatments on COVID-19-related healthcare resources. We estimated that public sector contributions led to at least 30% reductions in COVID-19-related healthcare resource utilization. Private sector contributions to expanded diagnostic testing and treatments led to further reductions in mortality (− 44%), intensive care unit (ICU) and non-ICU hospital beds (− 30% and − 28%, respectively), and ventilator use (− 29%). The combination of lower diagnostic test sensitivity and proportions of patients self-isolating may exacerbate case numbers, and policies that encourage self-isolating should be considered.
A magnetic nanoparticle labeled immunochromatography kit for sars-cov-2 infection diagnosis	Shen,  Q,  Liang, et al	Nano Biomedicine and Engineering	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In this paper, we designed a test strip which used the principle of double antigen sandwich. Fe3O4 magnetic nanobeads are firstly coupled with specific antibodies, and the S protein of the new coronavirus is used as the coating antigen to capture specific antibodies against the new coronavirus, which is used to detect the virus nucleoprotein of specific antibodies in clinical samples. At the same time, Fe3O4 magnetic nanobeads have unique magnetic properties, which can be used to generate different types of detection signals and simplify the detection process. These results can be judged by color changes and magnetic changes at the test and control lines. Compared with the traditional method, this test strip of Fe3O4 magnetic nanobeads has high sensitivity and can qualitatively detect samples within 15 minutes.
Elective open tracheostomy in a patient with covid-19	Šifrer,  R,  Iglič, et al	Zdravniski Vestnik	Healthcare Response | Réponse des soins de santé	The purpose of this article is to present adjustments of the elective open surgical tracheostomy in long-term intubated patients secondary to SARS-CoV-2 infection. We are describing the open tracheostomy in which harmonized and specific cooperation of the surgical and anaesthesiologic team, with steps planed in advance, is of utmost importance. In addition, the procedures should be executed without generating aerosolised particles.
Intravenous Administration of Umbilical Cord Mesenchymal Stromal Cells in Advanced-stage Critical COVID-19: a Case Report	Silva,  Katia Nunes,  Pinheiro, et al	Research Square prepub	Clinical data| Données cliniques	This is a case report of a 30-year-old male patient who presented progressive clinical deterioration of COVID-19 in ICU after 21-day admission and 14 days with invasive mechanical ventilation. The first symptom onset was 35 days before MSC therapy. The patient was treated with allogenic human umbilical cord-derived MSCs [5 x 107 (2 doses 2 days interval)].  No serious adverse events attributed to MSC administration were observed during and after the procedure. Oxygenation (PaO2/FiO2 ratio) and the need for vasoactive drugs improved.
COVID-19 Restrictions, Emerging Adulthood and Higher Education in Kazakhstan – Mental Health Impacts on Students	Simpson,  Ewan,  Mikkonen, et al	SSRN- Lancet prepublication	Mental Health | santé mentale	The COVID-19 pandemic has led to dramatic changes in higher education delivery and impacted the critical emerging adulthood phase for young people. This paper reports the results of a survey of undergraduate students in the Central Asian Republic of Kazakhstan in October 2020 related to their mental health after six months of online learning and relative social isolation. The impacts were found to be severe, with 17% of responses indicating moderate negative mental health effects and 14% indicative of severe negative mental health effects. Given that restrictions are projected to continue until at least May 2021, the potential long term effects on the life chances of young people currently in higher education are significant.
Factors Affecting Psychological Needs of Medical Workforce during the COVID-19: Evidence from India	Singh,  Hardeep,  Tyagi, et al	SSRN- Lancet prepublication	Mental Health | santé mentale	The purpose of this study is to identify factors affecting the psychological needs of the medical workforce in India during COVID-19. In this study, the interviews were conducted on semi-structured schedule to study the factors affecting the psychological needs of the medical workforce. The respondent includes the doctors and nurses directly involved in caregiving to COVID-19 infected patients. The relationship matrix plotted as RQDA output highlights anxiety, depression, and stress are the psychological factors affecting the medical workforce. The medical workforce needs the implementation of effective strategies to cope up in these challenging times and maintain their mental well-being.
COVID-19 autopsies: Procedure, technical aspects and cause of fatal course. Experiences from a single-center	Skok,  K,  Vander, et al	Pathology Research and Practice	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	Hereby, we report our experience about practicability, usefulness and feasibility of COVID-19 autopsies and our processing method for COVID-19 tissue samples. We further analyze the most important pathological findings causing death and report on the quality of the tissue obtained by autopsy for conventional histology, immunohistochemistry and molecular analysis.
Feasibility and acceptability of virtual academic detailing on opioid prescribing	Smart,  MH,  Mandava, et al	Int J Med Inform	Healthcare Response | Réponse des soins de santé	This study aimed to examine the feasibility and acceptability of a virtual academic detailing program implemented among health care providers in Illinois. There was a high level of satisfaction with the initial and follow up virtual academic detailing visits, though, among providers who participated in both visits and had completed surveys (n = 50), initial visits had slightly higher scores (mean difference = −2.94 [95 % Confidence intervals: −4.38, −1.50], p < 0.001). There was no significant difference in detailer perception across the two visits as seen in the scale summary score (0.05 [−0.56, 0.66], p = 0.86) and two individually reported items related to feasibility (0.07 [−0.29, 0.42], p = 0.72) and conversation (−0.05 [−0.28, 0.17], p = 0.63). Forty-one (44.6 %) virtual visits were conducted using WebEx, where video and screen sharing of visit content was possible, while the remaining 51 (55.4 %) were conducted using a telephone.
Covid-19 diagnosis in a patient with critical limb ischemia: Complications and clinical outcomes	Soares,  RA,  Vedovello, et al	Jornal Vascular Brasileiro	Clinical data| Données cliniques	This case report describes a patient with CLI who suffered a fatal outcome of Covid-19 infection during the postoperative period after an endovascular procedure, demonstrating that patients with peripheral arterial occlusive disease are linked to poorer prognosis when infected with SARS-Cov-2, due to medical comorbidities such as advanced age, hypertension, and diabetes. More trials of treatments for Covid-19 are needed in the literature.
Safety and efficacy of hydroxychloroquine in 152 outpatients with confirmed COVID-19: A pilot observational study	Sogut,  O,  Can, et al	American Journal of Emergency Medicine	Clinical data| Données cliniques Therapeutics| Thérapeutique	We investigated the efficacy and safety of hydroxychloroquine for empirical treatment of outpatients with confirmed COVID-19 through a prospective study that enrolled ambulatory outpatients. Our findings show that hydroxychloroquine is safe for COVID-19 and not associated with a risk of ventricular arrhythmia due to drug-induced QTc interval prolongation. Additionally, hydroxychloroquine was well tolerated, and there were no drug-related non-serious adverse events leading to treatment discontinuation in the majority of patients who were stable and did not require hospitalization
Preliminary impact of the COVID-19 pandemic on smoking and vaping in college students	Sokolovsky,  AW,  Hertel, et al	Addict Behav	Public Health response| Interventions de santé publique	We examined tobacco use changes in young adult college students in the context of the COVID-19 pandemic, focusing on smoking and vaping prior to their campus closing (PC) and past-week use since closing (SC). Both smoking and vaping frequency decreased from PC to SC; however, decreased frequency did not correspond to reduced quantity. Twenty-four participants (28.9%) paused past-week use SC. Higher anxiety and moving home (versus living independently) were related to increased odds of pausing, whereas COVID-19 related news exposure and seeking were related to decreased odds of pausing.
Dynamic monitoring of immune function indexes in COVID-19 patients	Song,  Y,  Zhong, et al	Aging (Albany NY)	Clinical data| Données cliniques Immunology | Immunologie	We conducted a retrospective analysis of the clinical characteristics and dynamic variations of immune indexes in nine COVID-19 patients in Zigong, China. We found that CRP, LDH, HBDH, CD4/CD8 and IgE levels were increased in 6/9 patients, while PA and the absolute numbers of CD4 and CD8 lymphocytes decreased in 7/9 patients. From disease onset through 63 days of follow-up, SARS-CoV-2 IgG levels were consistently higher than those of SARS-CoV-2 IgM, reaching peaks on days 28 and 13, respectively. IgM levels decreased to normal 35 days after disease onset, while IgG levels remained elevated through day 63. IgE levels varied similarly to SARS-CoV-2 IgM. Our results suggest that SARS-CoV-2 may elicit allergic immune responses in patients and that the levels of CRP, PA, LDH, and HBDH, as well as the absolute numbers of CD4 and CD8 lymphocytes could be used as early diagnostic markers of SARS-CoV-2 infection.
The existential dimension of the pandemic: Death attitudes, personal worldview, and coronavirus anxiety	Spitzenstätter,  D,  Schnell, et al	Death Stud	Mental Health | santé mentale	A cross-sectional survey to investigate relationships between coronavirus anxiety, individual death attitudes, and personal worldview was conducted among 202 German-speaking adults in Central Europe. Results indicated that death anxiety significantly predicts coronavirus anxiety beyond sociodemographic variables. Women reported higher coronavirus anxiety than men. Against expectations, dimensions of personal worldview were hardly related to coronavirus anxiety. In contrast, we found evidence for a curvilinear relationship between religiosity as well as atheism and negative death attitudes.
Stress and anxiety levels in pregnant and post-partum women during the COVID-19 pandemic	Stepowicz,  A,  Wencka, et al	International Journal of Environmental Research and Public Health	Mental Health | santé mentale	The aim of this study was to analyze stress and anxiety levels experienced by pregnant and post-partum women during the COVID-19 pandemic. Levels of stress and anxiety experienced by the surveyed patients were moderate to high. We demonstrated that women with mental treatment history, those in the first trimester of pregnancy and the ones that are single or in an informal relationship tend to experience higher levels of psychological distress and anxiety.
High rate of renal recovery in survivors of COVID-19 associated acute renal failure requiring renal replacement therapy	Stevens,  JS,  King, et al	PLoS One	Epidemiology| Épidémiologie Clinical data| Données cliniques	We describe the clinical characteristics of COVID-19 patients in the ICU with acute kidney injury (AKI) requiring renal replacement therapy (RRT) at an academic medical center in New York City. Our analysis demonstrates the high prevalence of AKI requiring RRT among critically ill patients with COVID-19 and is associated with a high mortality, however, the rate of renal recovery is high among survivors and should inform shared-decision making.
Māori and Pacific People in New Zealand have higher risk of hospitalisation for COVID-19	Steyn,  Nicholas,  Binny, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	We aim to quantify differences in clinical outcomes from COVID-19 infection by ethnicity with a focus on risk of hospitalisation in New Zealand. Māori have 2.5 times greater odds of hospitalisation than non-Māori, non-Pacific people, after controlling for age and pre-existing conditions. Similarly, Pacific people have 3 times greater odds.
A pilot study on right ventricular longitudinal strain as a predictor of outcome in COVID-19 patients with evidence of cardiac involvement	Stockenhuber,  A,  Vrettos, et al	Echocardiography	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim of this prospective observational study was to evaluate echocardiographic parameters of cardiac function and in particular right ventricular function as a predictor of mortality in patients with COVID-19 pneumonia. This study confirms that right ventricular longitudinal strain is a potent and independent predictor of outcome in COVID-19 patients with evidence of cardiac involvement.
Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic	Strich,  JR,  Ramos-Benitez, et al	J Infect Dis	Therapeutics| Thérapeutique	Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in Coronavirus Disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrate that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis.
Epidemiology and prevention strategies of SARS-CoV-2 infection in pediatric hematology and oncology centers in Poland	Styczyński,  J,  Balwierz, et al	Acta Haematologica Polonica	Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	Epidemiological analysis of SARS-CoV-2 infections in pediatric hematology and oncology (PHO) and hematopoietic cell transplant (HCT) centers in a Polish nationwide study, as well as analysis of the preventive strategies in these centers. Eight patients were positive for SARS-CoV-2. The estimated incidence of SARS-CoV-2 positivity in Polish PHO/HCT centers was 0.5%. In all but one case, the course of COVID-19 was asymptomatic or mild, and it was moderate in one case. Parents staying in the hospital together with their children were regularly tested for the virus in 13 centers. Asymptomatic healthcare personnel were regularly tested for the virus in seven centers.
ADHERENCE TO INTRAVENOUS BIOLOGICAL TREATMENT IN INFLAMMATORY BOWEL DISEASE PATIENTS DURING THE COVID-19 PANDEMIC	SuÁrez Ferrer,  C,  Perez Robles, et al	Rev Esp Enferm Dig	Healthcare Response | Réponse des soins de santé	The objective of this study was to determine the adherence to biological treatment in inflammatory bowel disease (IBD) patients during the COVID-19 pandemic, at the La Paz University Hospital in Madrid. Thirty patients (18.3%) were identified whose treatment was not administered on the indicated date. The reason was fear of going to the hospital due to COVID-19 in 43.3% of cases. In 20% (6 patients) of cases, the reason was due to a confirmed COVID-19 infection, being outside of Madrid in 26.7% (8 patients) and forgetfulness in 3 patients.
Age-Related Pattern and Distribution of Covid-19 on Pulmonary Computed Tomography	Sultan,  OM,  Alghazali, et al	Curr Med Imaging	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objective of this study was to characterize the pulmonary CT changes and distributions of COVID-19 infection in regard to different age groups. Bilateral and peripheral ground-glass opacities were the most frequent findings with the right side and lower lobar predilection. Compared with middle and old age groups, young adult patients showed significantly lesser frequency of consolidation, diffuse changes, bilateral disease, and multi-lobar involvement.
Retrospective cohort study comparing the epidemiological and clinical characteristics between imported and local COVID-19 inpatients in Nanyang, China	Sun,  C,  Liu, et al	J Investig Med	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study investigated the differences between the imported and local cases of COVID-19 in Nanyang, China. In this study, a total of 129 COVID-19 confirmed cases with a clear epidemiological history admitted to hospitals in Nanyang from January 24 to February 26, 2020 were enrolled. The early diagnosed cases were mainly imported cases, and the later diagnosed ones were mainly local cases. The most common first symptom was fever; moderate fever was commonly seen in imported cases whereas low fever was commonly seen in local cases. Lymphocyte counts in the imported group were lower than those in the local group. The imported group showed more advanced and severe abnormalities in the CT scan whereas the local group showed milder pulmonary abnormalities. The proportion of severe and critically severe patients in the imported group was higher than that in the local group.
Independent and combined effects of hypertension and diabetes on clinical outcomes in patients with COVID-19: A retrospective cohort study of Huoshen Mountain Hospital and Guanggu Fangcang Shelter Hospital	Sun,  Y,  Guan, et al	J Clin Hypertens (Greenwich)	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aims of this study were to evaluate the contributions of hypertension alone, type 2 diabetes mellitus (T2DM) alone, or their combination to the risk of death, acute respiratory distress syndrome (ARDS)/respiratory failure, and severe COVID-19 infection. Neither hypertension nor elevated blood pressure was independent risk factors for death or ARDS/respiratory failure but hypertension marginally increased the risk of severe COVID-19 infection. The risk associated with hypertension is accentuated through its confounding effect on T2DM.
COVID-19 plasma deep proteome reveals distinct signatures in severe patients	Suvarna,  Kruthi,  Biswas, et al	Research Square prepub	Clinical data| Données cliniques Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Here we employed a mass spectrometry-based label-free quantitative proteomics approach to study alteration in plasma proteome in a cohort of 73 patients (20 COVID negative, 18 non-severe, and 33 severe) to understand the disease dynamics. Of the 1200 proteins detected in the patient plasma, 38 proteins were differentially expressed between non-severe and severe groups. Utilizing our proteomics dataset and in silico docking, we identified multiple drugs that could inhibit the upregulated proteins involved in disease pathogenesis. 2 FDA-approved drugs, Selinexor and Ponatinib, showed promise of being re-purposed for potential therapeutics of COVID-19.
Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of Covid-19 death	Szekely,  Laszlo,  Bozoky, et al	bioRxiv	Clinical data| Données cliniques	Here we present twelve complete autopsies, including two rapid autopsies of young patients where the cause of death was Covid-19 ARDS. The main virus induced pathology was in the lung parenchyma and not in the airways. Most coagulation events occurred in the intra-alveolar space. The dominant inflammatory response was the massive accumulation of CD163+ macrophages and the disappearance of T killer, NK and B-cells. The virus was replicating in the pneumocytes and macrophages. The lung consolidations were produced by a massive regenerative response, stromal and epithelial proliferation and neovascularization.
Predictors of poor prognosis in patients with COVID-19	Tabares,  RG,  González, et al	Revista Cubana de Medicina Militar	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objective of this study was to identify risk factors for developing complications in patients treated with COVID-19.  Respiratory distress was more frequent in men. Risk factors were the history of arterial hypertension, ischemic heart disease, diabetes mellitus, chronic kidney insufficiency and dementia. Low hematocrit and lymphocytes were predisposed to complications, as well as high neutrophils, glycaemia, creatinine, ASAT, GGT and LDH.
An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2	Tada,  T,  Fan, et al	Cell Reports	Therapeutics| Thérapeutique Animal model | Modèle animal	We report on an improved soluble ACE2, termed a “microbody”. The disulfide-bonded ACE2 microbody protein inhibits entry of SARS-CoV-2 spike protein pseudotyped virus and replication of live SARS-CoV-2 in vitro and in a mouse model. Its potency is 10-fold higher than soluble ACE2, and it can act after virus bound to the cell. The microbody inhibits the entry of β coronaviruses and virus with the variant D614G spike. The ACE2 microbody may be a valuable therapeutic for COVID-19.
Immunomodulatory effects of nanocurcumin on Th17 cell responses in mild and severe COVID-19 patients	Tahmasebi,  S,  El-Esawi, et al	J Cell Physiol	Clinical data| Données cliniques Therapeutics| Thérapeutique Immunology | Immunologie RCT	The current clinical trial study was conducted in a randomized, double‐blind, placebo‐controlled approach to evaluate the therapeutic effects of nanocurcumin versus placebo. A significant decrease in the number of Th17 cells, downregulation of Th17 cell-related factors, and decreased levels of Th17 cell-related cytokines were found in mild and severe COVID-19 patients treated by nanocurcumin compared to the placebo group. Moreover, the abovementioned parameters were significantly decreased in the nanocurcumin-treated group after treatment versus before treatment. Curcumin could reduce the frequency of Th17 cells and their related inflammatory factors in both mild and severe COVID-19 patients.
Could we predict the prognosis of the COVID-19 disease?	Tahtasakal,  CA,  Öncül, et al	J Med Virol	Epidemiology| Épidémiologie Clinical data| Données cliniques	We aimed to predict poor prognosis among severe patients to lead early intervention. The clinical progress could be severe if the baseline values of NLR, CRP, troponin I, LDH, are above, LE is below the specified cut-off point. We found that the troponin I, elder age and SO(2) values could predict mortality.
Genomic diversity of SARS-CoV-2 can be accelerated by a mutation in the nsp14 gene	Takada,  Kosuke,  Ueda, et al	bioRxiv	Coronavirology| Coronavirologie	In this study, to understand genome evolution of SARS-CoV-2 in the current pandemic, we examined mutations of SARS-CoV-2 nsp14 which could inhibit its error-correcting function. We examined genome substitution rates of these mutants and found that an nsp14 mutant with a proline to leucine change at position 203 (P203L) showed a higher substitution rate than SARS-CoV-2 possessing wild-type nsp14. Results indicated that the molecular function of nsp14 is important for survival of various coronaviruses including SARS-CoV-2 and that some mutations such as P203L of nsp14 inhibiting its error-correcting function are removed rapidly due to their deleterious effects.
Community level of COVID-19 information exposure and influencing factors in northwest Ethiopia	Tamiru,  AT,  Rade, et al	Risk Management and Healthcare Policy	Public Health response| Interventions de santé publique	This community-based cross-sectional study aimed to evaluate the information exposure level about COVID-19 and influencing factors among northwest community of Ethiopia. Communities total level of good information exposure from different information platforms about COVID-19 in this study area remains low. Age, high level of education, browsing social media, and those having interpersonal (family and friends) discussion were the factors that significantly influence communities who have good information exposure related to COVID-19.
Comparative Clinical Evaluation of the Roche Elecsys and Abbott Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Serology Assays for Coronavirus Disease 2019 (COVID-19)	Tan,  SS,  Saw, et al	Arch Pathol Lab Med	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The objective of this study was to critically evaluate 2 commercially available SARS-CoV-2 serology tests (Roche E411 and Abbott Architect i4000SR). There was a strong level of agreement in the qualitative results between both assays. The specificity for both Roche and Abbott were excellent at 100%. Roche exhibited marginally better performance in the 21 days or more group with a sensitivity of 90.6% versus an Abbott sensitivity of 84.4%. Potential confounders for negative serologic results include antiretroviral medication use and pauci-symptomatic patients.
Higher mortality and intensive care unit admissions in COVID-19 patients with liver enzyme elevations	Taramasso,  L,  Vena, et al	Microorganisms	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim of this single-centre observational study is to evaluate if an independent association exists between liver enzyme elevations (LEE) and the risk of mortality or intensive care unit (ICU) admissions in patients with COVID-19. The clinical and laboratory variables associated with the development of LEE were male sex, higher respiratory rate, higher gamma glutamyl transpeptidase (GGT) and lower albumin levels at baseline. Among the analyzed treatments, steroids, tocilizumab and darunavir/ritonavir correlated with LEE.  In conclusion, LEE were associated with mortality and ICU admission among COVID-19 patients
Awake-Prone Positioning Strategy for Non-Intubated Hypoxic Patients with COVID-19: A Pilot Trial with Embedded Implementation Evaluation	Taylor,  SP,  Bundy, et al	Ann Am Thorac Soc	Healthcare Response | Réponse des soins de santé	The objective of this pilot study was to identify contextual factors relevant to the conduct of a definitive clinical trial evaluating a prone positioning strategy for non-intubated hypoxic patients with COVID-19.Five inpatient medical service teams were randomly allocated to two treatment arms: 1) usual care (UC) consisting of current, standard management of hypoxia and COVID-19; or 2) the Awake Prone Positioning Strategy plus usual care (APPS). Patients in the Usual Care group had a median nadir oxygen saturation to fraction of inspired oxygen ratio over the 48-hour study period of 216 versus 253 in the APPS group. Mixed methods analyses uncovered several barriers relevant to the conduct of a successful definitive RCT, including low adherence to prone positioning, large differences between physician-recommended and patient-tolerated prone durations, and diffusion of prone positioning into usual care.
Risk and Protective Factors of Loneliness among Older Adults: The Significance of Social Isolation and Quality and Type of Contact	Teater,  B,  Chonody, et al	Soc Work Public Health	Mental Health | santé mentale	This cross-sectional study explored possible risk and protective factors that can help explain loneliness and emotional and social loneliness in a sample of community-dwelling older adults (N = 477). Results indicated overall quality of contact with others, use of phone contact, and social isolation was significant in all three regressions; other significant variables were different for each analysis.
PMC7665343; Can Outpatient Plastic Surgery Be Done Safely During a COVID-19 Surge? Results of a July 2020 Los Angeles Survey and Literature Review	Teitelbaum,  S,  Diaz, et al	Aesthet Surg J	Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé	This aim of this survey was to assess the safety of plastic surgery during the pandemic by quantifying: (1) the preoperative prevalence of SARS-CoV-2; (2) the risk of postoperative COVID-19; (3) outcomes and precious resource utilization for such cases; and (4) the risks to office staff.  The preoperative PCR test was positive in 41/5881 (0.69%). Positive tests within 2 weeks postoperation occurred in 7/5380 (0.13%) of surgical patients, 3/8506 (0.04%) of injection patients, and 6/2519 (0.24%) of energy therapy patients. Nine offices reported at least 1 staff member who developed COVID-19. All cases were mild, with no hospitalizations or deaths.
COVID-19 Infection Prevention and Control Adherence in Long-term Care Facilities, Atlanta, Georgia	Telford,  CT,  Bystrom, et al	J Am Geriatr Soc	Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé	Site visits to 24 long-term care facilities (LTCFs) in Fulton County, Georgia, were conducted between June and July 2020 to assess adherence to current infection prevention and control (IPC) guidelines. IPC implementation was lowest in the Disinfection category (32%) and highest in the Symptom Screening category (74%). LTCFs with lower COVID-19 prevalence among residents had significantly greater implementation of IPC recommendations compared to those with higher COVID-19 prevalence.
Mental health impact of COVID-19 on quarantine hotel employees in China	Teng,  YM,  Wu, et al	Risk Management and Healthcare Policy	Mental Health | santé mentale	This research attempts to explore COVID-19-related depression, anxiety, and stress among quarantine hotel employees in China. The results reveal that 43.5% of respondents report moderate to extremely severe symptoms of depression; 68.2% have moderate to extremely severe anxiety symptoms; and 8.2% indicated moderate to extremely severe stress symptoms. Quarantine hotel employees who have a higher level of education are less likely to experience anxiety, and those with higher incomes are less likely to experience depression.
The molecular mechanism of domain-swapping of the C-terminal domain of the SARS coronavirus main protease	Terse,  VL,  Gosavi, et al	Biophys J	Coronavirology| Coronavirologie	Domain-swapping in the α-helical C-terminal domain of the main protease (M(pro)) of SARS coronavirus (M(pro)C) locks M(pro) into a hyperactive octameric form which is hypothesized to promote the early stages of viral replication. We investigate the mechanism of domain-swapping of M(pro)C using coarse-grained structure-based models and molecular dynamics simulations. Our simulations recapitulate several experimental features of M(pro)C folding. Further, we find that a contact between a tryptophan in the M(pro)C domain-swapping hinge and an arginine elsewhere forms early during folding, modulates the folding route and promotes domain-swapping to the native structure.
Intimate partner violence among antenatal care attendees amidst the COVID-19 crisis: The incidence in Ethiopia	Teshome,  A,  Gudu, et al	Int J Gynaecol Obstet	Public Health response| Interventions de santé publique	The objective of this study was to assess the incidence and predictors of intimate partner violence (IPV) during pregnancy amidst the COVID19 pandemic in Ethiopia. Among the 464 pregnant women, 33 (7.1%) reported IPV during pregnancy. Partners drinking alcohol and chewing Khat are significantly positively associated with IPV during pregnancy.
Development and head-to-head comparison of twocolloidal gold based serologiclateral flow assays for SARS-CoV-2 antibody tests	Tian,  J,  Wang, et al	Nano Biomedicine and Engineering	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	This study evaluated sensitivity of two different designs of colloidal gold serologic tests  by using residual serum samples from patients who were evaluated for SARS-CoV-2 infection status by polymerase chain reaction. The results showed 100% specificity for both tests, while when testing of 16 positive patients, the data showed 90% sensitivity for total antibody test and 30% for IgG test.
Prevalence of Health Care and Hospital Worker SARS-CoV-2 IgG Antibody in a Pediatric Hospital	Tokareva,  Y,  Englund, et al	Hosp Pediatr	Epidemiology| Épidémiologie Immunology | Immunologie	This study aimed to determine prevalence of SARS-CoV-2 IgG antibody in healthcare and hospital workers (HCHW) and assess how antibody levels change over time. In total, 530 participants enrolled and completed baseline study activities. SARS-CoV-2 antibody was detected in 1% of HCHW in an urban pediatric hospital, in a city with moderate SARS-CoV-2 prevalence. Participants with a known prior COVID-19 diagnosis showed a decline or loss of IgG antibody over 2 months.
Prognostic and predictive biomarkers in patients with COVID-19 treated with tocilizumab in a randomised controlled trial	Tom,  Jennifer,  Bao, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique RCT	We explored prognostic and predictive biomarkers with efficacy outcomes after treatment with tocilizumab, an anti–IL-6 receptor antibody using data from the COVACTA trial for patients hospitalised with severe COVID-19 pneumonia. All candidate biomarkers except LDH and D-dimer were strongly prognostic for day 28 clinical outcomes of mortality, mechanical ventilation, clinical status, and time to hospital discharge. Ferritin was identified as a predictive biomarker for the effects of tocilizumab in the COVACTA patient population; high ferritin levels were associated with better clinical outcomes for tocilizumab compared with placebo at day 28.
Patterns of within-host genetic diversity in SARS-CoV-2	Tonkin-Hill,  Gerry,  Martincorena, et al	bioRxiv	Coronavirology| Coronavirologie	Here we describe the patterns of within-host diversity in 1,181 SARS-CoV-2 samples sequenced to high depth in duplicate. Results show that much of the genetic diversity of the SARS-CoV-2 viral population resides within individual hosts. Within-host diversity is generated by the accumulation of de novo mutations during the course of infection but can also result from co-infection with different lineages.
First Reported Case in Romania of a Successfully Treated Severe COVID-19 in a Kidney Transplant Recipient: A Focus on Acute Kidney Injury	Tosa,  F,  Manaila, et al	Case Reports in Nephrology and Dialysis	Clinical data| Données cliniques	We report on a case of a 46-year-old kidney transplant recipient who was successfully treated for severe COVID-19 pneumonia. The clinical course was complicated by transient acute kidney injury, most likely due to tubulo-interstitial involvement, with return to the baseline of the creatinine level by the time of discharge.
COVID-MATCH65—A prospectively derived clinical decision rule for severe acute respiratory syndrome coronavirus 2	Trubiano,  JA,  Vogrin, et al	PLoS ONE	Epidemiology| Épidémiologie Clinical data| Données cliniques	We report on the key clinical predictors of SARS-CoV-2 infection. Of 4226 patients with suspected COVID-19 who were assessed in Melbourne Australia, 2976 patients underwent SARS-CoV-2 testing (n = 108 SARS-CoV-2 positive) and were used to determine factors associated with a positive COVID-19 test. The 7 features associated with a positive COVID-19 test on multivariable analysis were: COVID-19 patient exposure or international travel, Myalgia/malaise, Anosmia or ageusia, Temperature, Coryza/sore throat, Hypoxia–oxygen saturation < 97%, 65 years or older—summarized in the mnemonic COVID-MATCH65. Internal validation showed an AUC of 0.836. A cut-off of ≥ 1.5 points was associated with a 92.6% sensitivity and 99.5% negative predictive value (NPV) for COVID-19.
Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19	Trump,  S,  Lukassen, et al	Nat Biotechnol	Clinical data| Données cliniques Therapeutics| Thérapeutique Immunology | Immunologie	Combining clinical data (n = 144) and single-cell sequencing data of airway samples (n = 48) with in vitro experiments, we observed a distinct inflammatory predisposition of immune cells in patients with hypertension that correlated with critical COVID-19 progression. ACEI treatment was associated with dampened COVID-19-related hyperinflammation and with increased cell intrinsic antiviral responses, whereas ARB treatment related to enhanced epithelial-immune cell interactions. Macrophages and neutrophils of patients with hypertension, in particular under ARB treatment, exhibited higher expression of the pro-inflammatory cytokines CCL3 and CCL4 and the chemokine receptor CCR1. ARB but not ACEI treatment was associated with delayed SARS-CoV-2 clearance.
COVID-19 Associated Mortality and Cardiovascular Disease Outcomes Among U.S. Women Veterans	Tsai,  Shirling,  Nguyen, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques	We conducted a case-control cohort study to examine COVID-19-associated mortality and cardiovascular disease outcomes after testing among a racially diverse adult women veteran population. SARS-CoV-2 infection increased short-term mortality risk among women veterans similarly across race groups. However, there was no evidence of increased cardiovascular disease incidence in 60 days.
Oral clarithromycin in COVID-19 of moderate severity: the ACHIEVE open-label trial using concurrent matched comparators	Tsiakos,  Konstantinos,  Tsakiris, et al	medRxiv	Clinical data| Données cliniques Therapeutics| Thérapeutique Immunology | Immunologie	This open-label non-randomized trial aimed to answer the research question: Is oral clarithromycin beneficial for treating patients diagnosed with COVID-19? Clarithromycin treatment was associated with early clinical improvement in patients with moderate COVID-19. Clarithromycin use was associated with decreases in circulating levels of C-reactive protein, of tumour necrosis factor-alpha and of interleukin (IL)-6; by an increase of the ratio of Th1 to Th2 mononuclear responses; and by suppression of SARS-CoV-2 relative viral load.
Anxiety, meaning in life, self-efficacy and resilience in families with one or more members with special educational needs and disability during COVID-19 pandemic in Greece	Tsibidaki,  A	Res Dev Disabil	Mental Health | santé mentale	This study explores anxiety, meaning in life, self-efficacy and resilience in university students belonging to families with one or more members with special educational needs and disability during the COVID-19 pandemic in Greece. Participants presented higher levels of anxiety, meaning in life (presence), general self-efficacy and resilience (than average scale). Parents had higher values than university students in state anxiety, state-trait anxiety (total), meaning in life (presence) and resilience. Individuals with higher levels of resilience and meaning in life had lower anxiety levels.
The mechanism of SARS-CoV-2 nucleocapsid protein recognition by the human 14-3-3 proteins	Tugaeva,  KristinaV,  Hawkins, et al	bioRxiv	Coronavirology| Coronavirologie	We show that phosphorylated SARS-CoV-2 N protein (pN) dimers, reconstituted via bacterial co-expression with protein kinase A, directly associate, in a phosphorylation-dependent manner, with the dimeric 14-3-3 protein hub. We demonstrate that pN is recognized by all seven human 14-3-3 isoforms with various efficiencies and determine the apparent KD to selected isoforms in a low micromolar range. Serial truncations pinpointed a critical phosphorylation site to Ser197, located within the SR-rich region of N. The tight 14-3-3/pN association suggests it could regulate nucleocytoplasmic shuttling of N, while hijacking cellular pathways by 14-3-3 sequestration. As such, the assembly may represent a valuable target for therapeutic intervention.
Clinical Evaluation of Locally Made Flocked Swabs in Response to the COVID-19 Pandemic in a Developing Country	Tunjung,  N,  Kreshanti, et al	International Journal of Technology	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Our institution developed locally made nasopharyngeal swabs. This report aims to provide a clinical evaluation by conducting a sterility test, reverse transcription polymerase chain reaction (RT-PCR) compatibility test, and a user-based survey test of two batches of locally made flocked swabs. The sterility test showed no evidence of bacterial growth on both blood agar and thioglycolate medium. RT-PCR compatibility test from Ct value of 33 samples of the first batch and 30 samples of the second batch was recorded with a mean Ct of 27.17±2.96 and 23.99±2.18, respectively. Six parameters of the swab stick (comfortability, smoothness, flexibility, durability, applicability, and breakpoint performance) showed satisfactory scores.
Experimental SARS-CoV-2 infection of bank voles - general susceptibility but lack of direct transmission	Ulrich,  Lorenz,  Michelitsch, et al	bioRxiv	Transmission Clinical data| Données cliniques Animal model | Modèle animal	After experimental inoculation, SARS-CoV-2 infection was proven for bank voles by seroconversion within eight days and detection of viral RNA in nasal tissue for up to 21 days. However, transmission to contact animals was not detected. Therefore, bank voles are unlikely to establish effective SARS-CoV-2 transmission cycles in nature.
Willingness of long-term care staff to receive a COVID-19 vaccine: A single state survey	Unroe,  KT,  Evans, et al	J Am Geriatr Soc	Healthcare Response | Réponse des soins de santé	This survey data provides insight into the willingness of front line staff to receive the vaccine as soon as it is available, including what groups of people among nursing home staff may have greater concerns and what those concerns are. Nursing home and assisted living facility staff in Indiana were surveyed. Overall, 45% of respondents indicated they would receive an approved COVID-19 vaccine as soon as available. Of those unwilling to take the vaccine when first available, 44% would consider in the future. Concerns about side effects was the primary reason for vaccine hesitancy (70%). Characteristics associated with increased willingness were age over 60, male, and white race. No statistically significant differences were observed among staff self-reporting prior SARS-CoV-2 infection.
Impact of the COVID-19 epidemic on eating habits and lifestyle : An east nusa tenggara survey	Utama,  LJ,  Yunianto, et al	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	This research aimed to find out the lifestyle of the people in East Nusa Tenggara, Indonesia, during the emergency response phase of COVID-19. Information about COVID-19 was mostly obtained from the internet or social media was 71.20%. The 98.43% of East Nusa Tenggara society tended to wear masks outside of their house, and 85.34% always wash their hands using soap.  Factors that changed during the Covid-19 virus pandemic were smoking, physical activity, consumption, washing hands, wearing masks, sunbathing, and processed foods consumption.
The effect of early-stage public health policies in the transmission of COVID-19 for South American countries	Valcarcel,  B,  Avilez, et al	Revista Panamericana de Salud Publica/Pan American Journal of Public Health	Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions de sant&amp;eacute; publique	This study sought to estimate the basic (R0) and time-varying (Rt) reproduction number of COVID-19 and contrast the public health measures for ten South American countries. Countries used a combination of isolation, physical distancing, quarantine, and community-wide containment measures to staunch the spread of COVID-19 at different points in time. R0 ranged from 1.52  in Venezuela to 3.83 in Chile, whereas Rt after 90 days ranged from 0.71 in Uruguay to 1.20 in Brazil. Different R0 and Rt values may be related to the testing capacity of each country.
Analyses of abdominal adiposity and metabolic syndrome as risk factors for respiratory distress in COVID-19	Van Zelst,  CM,  Janssen, et al	BMJ Open Respiratory Research	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study investigated prospectively the relationship between respiratory deterioration and the presence of metabolic syndrome or abdominal adiposity in patients with COVID-19. This study shows that abdominal adiposity, and not the presence of metabolic syndrome, is associated with clinical deterioration in COVID-19. This prospective study provides further insight into the risk stratification of patients with COVID-19 based on a simple measurement as the waist and hip circumference.
Public perspective on the governmental response, communication and trust in the governmental decisions in mitigating COVID-19 early in the pandemic across the G7 countries	Vardavas,  C,  Odani, et al	Preventive Medicine Reports	Public Health response| Interventions de santé publique	We assessed public attitudes towards governmental actions to combat the COVID-19 pandemic in the G7 countries. Amongst the G7, Japan had the lowest level of approval of governmental response to the pandemic followed by the US. Understanding of which measures one can personally take to help limit the spread of the coronavirus was significantly associated with approving governmental response, rating government communication as good, and trust in future governmental decisions.
Berberine and obatoclax inhibit SARS-CoV-2 replication in primary human nasal epithelial cells in vitro	Varghese,  FinnyS,  van Woudenbergh, et al	bioRxiv	Therapeutics| Thérapeutique	We demonstrate that berberine and obatoclax, two broad-spectrum antiviral compounds, are effective against multiple isolates of SARS-CoV-2. Berberine, a plant-derived alkaloid, inhibited SARS-CoV-2 at low micromolar concentrations and obatoclax, originally developed as an anti-apoptotic protein antagonist, was effective at sub-micromolar concentrations.
Relationship between serum osteopontin levels and the severity of COVID-19 infection	Varım,  C,  Demirci, et al	Wien Klin Wochenschr	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim of the present study was to reveal the place of serum osteopontin levels in predicting severity among patients with COVID-19. Patients were divided into 2 groups, non-severe and severe. There were no significant differences in terms of gender and platelet count. The osteopontin levels were found to be statistically higher in the severe group.
Factors associated with psychological coping with covid-19 during quarantine period	Vera-Ponce,  V,  Valladares-Garrido, et al	Revista Cubana de Medicina Militar	Mental Health | santé mentale Public Health response| Interventions de santé publique	The objective was to determine the factors associated with psychological coping to COVID-19 in the general population in Peru. Of 463 participants, the majority were  fully complying with social isolation measures (78,4 %). Having a high educational level and compliance with social isolation were positively associated with a high level of active coping.
Repurposing potential of FDA-approved and investigational drugs for COVID-19 targeting SARS-CoV-2 spike and main protease and validation by machine learning algorithm	Verma,  AK,  Aggarwal, et al	Chemical Biology and Drug Design	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	The present study aimed to assess the repurposing potential of existing antiviral drug candidates (FDA-approved and investigational) against SARS-CoV-2 target proteins that facilitates viral entry and replication into the host body. The molecular interaction analysis showed that cordycepin has strong binding affinities with S protein and Mpro proteins which were relatively highest among other drug candidates used. Furthermore, machine learning algorithm also revealed high applicability scores of cordycepin. Cordycepin's anti-SARS-CoV-2 activity indicated 65% (E-gene) and 42% (N-gene) viral replication inhibition after 48h of treatment.
Albumin Supplementation Dampens Hypercoagulability in COVID-19: A Preliminary Report	Violi,  F,  Ceccarelli, et al	Thromb Haemost	Clinical data| Données cliniques Therapeutics| Thérapeutique	We tested the hypothesis that albumin supplementation could dampen hypercoagulability in SARS-CoV-2 with serum albumin <3.5 g/dL. This is an observational cohort study performed at a large university hospital located in Italy. We found a significant increase of serum albumin in albumin-treated patients coincidentally with a marked reduction of D-dimer, while no changes of D-dimer and serum albumin were detected in the control group. This finding suggests that albumin exerts an anticoagulant activity in human, thereby its supplementation could turn useful in SARS-CoV-2 patients.
Biomarkers for CNS injury in CSF are elevated in COVID-19 and associated with neurological symptoms and disease severity	Virhammar,  J,  Nääs, et al	Eur J Neurol	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study examines cerebrospinal fluid (CSF) for biomarkers of central nervous system (CNS) injury and other pathology in relation to neurological symptoms and disease severity in patients with neurological manifestations of COVID-19. Data suggest that levels of neurofilament light chain protein (NfL), glial fibrillary acidic protein and total tau in CSF are commonly elevated in patients with COVID-19 with neurological symptoms. Increased NfL correlated with disease severity, time in intensive care and level of consciousness. NfL in CSF was higher in patients with central neurological symptoms.
Pathological lung changes in COVID-19 deceased patients	Vlačić,  G,  Kovačević, et al	Zdravniski Vestnik	Clinical data| Données cliniques	The aim of the analysis of deceased patients with SARS-CoV-2 virus infection is to assess histopathological changes in the lungs as the key target organ in this infection. The main histopathological finding was diffuse alveolar damage with hyaline membrane formation, interstitial and alveolar oedema and fibrinous exudation in the alveoli. Interstitial inflammatory infiltration was mild to moderate. In some patients, alveolar damage was partly organized, but without the presence of fibrosis. We found cytopathic changes of the alveolar epithelium consistent with viral infection in all patients. We found the presence of virus in lung samples of all patients.
Demonstrated SARS-CoV-2 Surface Disinfection Using Ozone	Volkoff,  SJ,  Carlson, et al	Ozone: Science and Engineering	Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)	In this work, we validate the efficacy of O3 technology on SARS-CoV-2 disinfection and demonstrate room-scale diffusion for use in occupational settings. We utilized RT-qPCR to measure RNA from a recombinant mammalian cell product, bacteriophage MS2, and SARS-CoV-2 sourced from municipal wastewater, after exposure to 4.5 and 9 ppmv O3.
Genomic characterization of a novel SARS-CoV-2 lineage from Rio de Janeiro, Brazil	Voloch,  CarolinaM,  da, et al	medRxiv	Coronavirology| Coronavirologie	In this study, we report the sequencing of 180 new viral genomes obtained from different municipalities of the state of Rio de Janeiro from April to December 2020. We identified a novel lineage of SARS-CoV-2, originated from B.1.1.28, distinguished by five single-nucleotide variants (SNVs). The SNV G23012A (E484K), in the receptor-binding domain of Spike protein, was widely spread across the samples. The significant increase in the frequency of this lineage raises concerns about public health management and continuous need for genomic surveillance during the second wave of infections.
Screening Donors for COVID-19 Convalescent Plasma	Wang,  HE,  Ostrosky-Zeichner, et al	Transfusion	Public Health response| Interventions de santé publique	We describe our experience engaging persons recovered from COVID-19 to donate COVID-19 convalescent plasma (CCP) in Texas. In this community, screening of a high number of candidates yielded a limited number of CCP donations. Of 360 contacted volunteers, 186 (5.7%) were excluded by interview; 133 were referred for additional diagnostic screening, 97 completed donor antibody and antigen testing, and 87 were qualified for CCP donation, resulting in 35 CCP donations. Among 533 referred donors, only 1 CCP donation occurred.
Study Problems and Depressive Symptoms in Adolescents During the COVID-19 Outbreak: Poor Parent-child Relationship as a Vulnerability	Wang,  Jingyi,  Wang, et al	Research Square prepub	Mental Health | santé mentale	We aimed to investigate the prevalence of depressive symptoms, their association with study-relevant problems, and the moderating effect of parent-child relationship among Chinese adolescents during the school closures. Using data from 6435 adolescents, we found that the prevalence of depressive symptoms was 17.7%. All the study problem measures were associated with more severe depressive symptoms. There was a moderating effect of the parental relationship on the associations between study problems and depressive symptoms.
Evaluation of COVID-19 Epidemic Based on SIR Model	Wang,  L		Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	Based on the SIR model, this article evaluates the efficiency of certain measures regarding new coronavirus (COVID-19). The data from the Provincial Health Committee and WHO are used to establish SIR model and draw graphs for evaluation. Simulations and pictures of SIR-F model are cited to predict the efficiency of certain measures. This article analyzes how the epidemic was regulated in different regions. The result shows that it is necessary to introduce strict regulations and take immediate actions so as to reduce the further spread of the virus.
Reduced Treatment Sensitivity of SARS-CoV-2 After Multigenerational Human-to-Human Transmission	Wang,  Q,  Yang, et al	Frontiers in Physics	Transmission	In this present study, based on the public information of COVID-19 in Qingdao, Shandong Province, China, we analyzed the epidemiological characteristics and treatment effects of 60 confirmed cases.  In Hubei-related patients, the earlier transmission generation, which refers to the imported patients (G0) and the first-generation infections (G1), was associated with reduced cure time. Therefore, we speculated that the treatment sensitivity of SARS-CoV-2 decreased within interpersonal transmission in the early stage of this epidemic.
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses	Wang,  R,  Simoneau, et al	Cell	Coronavirology| Coronavirologie	Here, we conducted genome-wide CRISPR screens in cells infected by SARS-CoV-2 as well as two seasonally circulating common cold coronaviruses, OC43 and 229E. This approach correctly identified the distinct viral entry factors ACE2 (for SARS-CoV-2), aminopeptidase N (for 229E), and glycosaminoglycans (for OC43). Additionally, we identified phosphatidylinositol phosphate biosynthesis and cholesterol homeostasis as critical host pathways supporting infection by all three coronaviruses. By contrast, the lysosomal protein TMEM106B appeared unique to SARS-CoV-2 infection.
Healthy neonate born to a SARS-CoV-2 infected woman: A case report and review of literature	Wang,  RY,  Chen, et al	World Journal of Clinical Cases	Clinical data| Données cliniques	The patient was a 36-year-old pregnant woman in her third trimester who had developed progressive clinical symptoms when she was confirmed as infected with SARS-CoV-2. Given the potential risks for both the pregnant woman and the fetus, an emergency cesarean section was performed, and the baby and his mother were separately quarantined and cared for. As a result, the baby currently shows no signs of SARS-CoV-2 infection.
Changes in inflammatory and immune drivers in response to immunomodulatory therapies in COVID-19	Wang,  StephenY,  Chang, et al	medRxiv	Therapeutics| Thérapeutique Immunology | Immunologie	To better understand the mechanistic basis of immunomodulatory therapies being implemented for treatment of COVID-19, we assessed longitudinal biochemical changes in response to such approaches in hospitalized patients with COVID-19. We demonstrate broad suppression of multiple immunomodulatory factors associated with adverse clinical outcomes in COVID-19 in patients who received corticosteroids, but no such response was seen in patients who either received tocilizumab or no immunomodulatory therapy.
Inferring key epidemiological parameters and transmission dynamics of COVID-19 based on a modified SEIR model	Wang,  X,  Tang, et al	Mathematical Modelling of Natural Phenomena	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission	We propose a modified SEIR model with a two-phase removal rate of quarantined hosts undergoing continuously tunable transition. We employ the Markov Chain Monte Carlo (MCMC) approach for inferring and forecasting the epidemiological dynamics from the publicly available surveillance reports. The effectiveness of a short-term prediction is illustrated by adopting the data sets from 10 demographic regions including Chinese mainland and South Korea. In the surveillance period, the average R0 ranges from 1.74 to 3.28, and the median of the mean latent period does not exceed 10 days across the surveillance regions. These plots show that the asymptomatic ratio of the United States exhibits a more obvious increment to the other ones, and the standard deviation of the prediction to the asymptomatic ratio of Japan is relatively high.
Evaluating the Effectiveness of COVID-19 Prevention and Control Measures Based on SEIR Model	Wang,  Y		Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions de santé publique	This article uses a modified SEIR model, counting asymptomatic infectious people and combined data from health authorities and simulation to analyze the efficacy of prevention and control measures. This paper also calculates the basic reproduction number of COVID-19. The uncertainty caused by asymptomatic infectious people is testified in this study. Under tense prevention and control measures, the epidemic of COVID-19 will be resolved soon in spite of the presence of asymptomatic infectious people.
Whom to Test? Active Sampling Strategies for Managing COVID-19	Wang,  Yingfei,  Yahav, et al	ArXiv	Public health interventions*| Interventions de sant&amp;eacute; publique	This paper presents methods to choose individuals to test for infection during a pandemic such as COVID-19, characterized by high contagion and presence of asymptomatic carriers. ur active sampling method works in conjunction with quarantine policies, can handle different objectives, is dynamic and adaptive in the sense that it continually adapts to changes in real-time data. Using a data-driven agent-based model simulating New York City we show that the algorithm samples individuals to test in a manner that rapidly traces infected individuals. Experiments also suggest that smart-testing can significantly reduce the death rates as compared to current methods such as testing symptomatic individuals with or without contact tracing.
Mental health symptoms in a cohort of hospital healthcare workers following the first peak of the COVID-19 pandemic in the UK	Wanigasooriya,  K,  Palimar, et al	BJPsych Open	Mental Health | santé mentale	AIMS: We evaluated the rates of anxiety, depressive and post-traumatic stress disorder (PTSD) symptoms in a population of HCW in the UK. The rates of clinically significant symptoms of anxiety, depression and PTSD were 34.3%, 31.2% and 24.5%, respectively. The availability of adequate personal protective equipment (PPE), well-being support and lower exposure to moral dilemmas at work demonstrated significant negative associations with these symptoms.
PMC7499632; Potential for inter-state spread of Covid-19 from Arizona, USA: analysis of mobile device location and commercial flight data	Watts,  A,  Au, et al	J Travel Med	Epidemiology| Épidémiologie	We evaluate the potential for domestic dissemination of SARS-CoV-2 from Arizona using mobile device-location and scheduled flights data. The top 10 flight destination cities originating from AZ, based on maximum seat capacity on scheduled flights, in descending order, are Los Angeles (CA), San Francisco (CA), San Diego (CA), Dallas/Fort Worth (TX), Houston (TX), Denver (CO), Chicago (IL), Las Vegas (NV), Seattle (WA) and Salt Lake City (UT). All of these destinations demonstrated a rise in confirmed COVID-19 case counts between June and July 2020.
PMC7685055; Front-line Nursing Home Staff Experiences During the COVID-19 Pandemic	White,  EM,  Wetle, et al	J Am Med Dir Assoc	Healthcare Response | Réponse des soins de santé	Our objective was to document the experiences of these front-line health care professionals during the pandemic. Respondents described ongoing constraints on testing and continued reliance on crisis standards for extended use and reuse of personal protective equipment. Direct-care staff expressed fears of infecting themselves and their families, and expressed sincere empathy and concern for their residents. They described experiencing burnout due to increased workloads, staffing shortages, and the emotional burden of caring for residents facing significant isolation, illness, and death.
Homogeneous Interpretable Approximations to Heterogeneous SIR Models	Wilkinson,  Ryan,  Roper, et al	ArXiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	Although real populations have heterogeneities in contacts not represented in the SIR model, it nevertheless well fits real US state Covid-19 case data. Here we demonstrate mathematically how closely the simple continuous SIR model approximates a model which includes heterogeneous contacts, and provide insight onto how one can interpret parameters gleaned from regression in the context of heterogeneous dynamics.
Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions and monocytes for optimal therapeutic protection	Winkler,  EmmaS,  Gilchuk, et al	bioRxiv	Immunology | Immunologie Animal model | Modèle animal	Here, we define correlates of protection of neutralizing human monoclonal antibodies (mAbs) in SARS-CoV-2-infected animals. Whereas Fc effector functions are dispensable when representative neutralizing mAbs are administered as prophylaxis, they are required for optimal protection as therapy. When given after infection, intact mAbs reduce SARS-CoV-2 burden and lung disease in mice and hamsters better than loss-of-function Fc variant mAbs.
Spreading of COVID-19: Density matters	Wong,  DWS,  Li, et al	PLoS One	Epidemiology| Épidémiologie	This study shows that population density is an effective predictor of cumulative infection cases in the U.S. at the county level. Daily cumulative cases by counties are converted into 7-day moving averages. This study assesses how population density has shaped the distributions of infection cases across the U.S. from early March to late May, 2020. Population density alone accounts for 57% of the variation (R-squared) in the aspatial models and up to 76% in the spatial models. Adding the three population subgroup percentage variables raised the R-squared of the aspatial models to 72% and the spatial model to 84%. The influences of the three population subgroups were substantial, but changed over time, while the contributions of population density have been quite stable after the first several weeks, ascertaining the importance of population density in shaping the spread of infection in individual counties, and in their neighboring counties.
Incremental costs associated with length of hospitalization due to viral pneumonia: Impact of intensive care and economic implications of reducing the length of stay in the era of covid-19	Wu,  N,  Kuznik, et al	ClinicoEconomics and Outcomes Research	Healthcare Response | Réponse des soins de santé Economics | Économie	Objective: To estimate incremental costs per day of hospitalization for a patient with influenza or viral pneumonia, as a proxy for COVID-19; ICU costs associated with invasive mechanical ventilation (iMV) were also determined. Results: Estimated incremental base case costs per additional inpatient day were $2158 and $3900 in the commercial population for uncomplicated hospitalizations and hospitalizations with ICU, respectively, and $475 and $668, respectively in the Medicare population. Estimated incremental base case costs per additional ICU day were $5254 and $608 for Commercial and Medicare populations, respectively. Use of iMV increased costs by $35,482 and $13,101 in the commercial and Medicare populations, respectively.
Real-time monitoring epidemic trends and key mutations in SARS-CoV-2 evolution by an automated tool	Xi,  Binbin,  Jiang, et al	bioRxiv	Coronavirology| Coronavirologie	The AutoVEM tool developed in the present study could complete all mutations detections, haplotypes classification, haplotype subgroup epidemic trends and key mutations analysis for 131,576 SARS-CoV-2 genome sequences in 18 hours on a 1 core CPU and 2G internal storage computer. Through haplotype subgroup epidemic trends analysis of 131,576 genome sequences, the great significance of the previous 4 specific sites (C241T, C3037T, C14408T and A23403G) was further revealed, and 6 new mutation sites of highly linked (T445C, C6286T, C22227T, G25563T, C26801G and G29645T) were discovered for the first time that might be related to the infectivity, pathogenicity or host adaptability of SARS-CoV-2.
Association of ACEI/ARB, inflammatory cytokines, and antiviral drugs with liver dysfunction in patients with hypertension and COVID-19	Xiang,  D,  Ren, et al	Clin Exp Hypertens	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study aims to investigate whether ACEI/ARB aggravates liver injury and the association of inflammatory cytokines and antiviral drugs with liver dysfunction in patients with hypertension and COVID-19.  Of the 127 patients with COVID-19 and hypertension, 43 taking long-term of ACEI/ARBs and 84 without using ACEI/ARBs. Abnormal liver function was observed in part of ACEI/ARB and non-ACEI/ARB users but without significant differences between these two groups. Serum inflammatory cytokines, IL-6, IL-8, and TNFα, as well as inflammation-related markers, ferritin, procalcitonin, and C-reactive protein, were significantly elevated in patients with liver dysfunction. IL-6 level was positively correlated with liver function tests on admission and highly consistent with the changes of abnormal ALT, AST, and GGT during hospitalization, but the correlations of other inflammatory cytokines were low.
Renal dysfunction and prognosis of COVID-19 patients: a hospital-based retrospective cohort study	Xiang,  Hui-Xian,  Xiang, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques Long-Term Sequelae | séquelles à long terme	This prospective case-cohort study analyzed 154 COVID-19 patients from the Second People’s Hospital of Fuyang City in Anhui Province. Of 154 hospitalized patients with COVID-19, 125 were common and 29 were severe patients. On admission, 16 (10.4%) patients were with renal dysfunction. Serum creatinine and cystatin C were increased, eGFR was decreased in severe patients compared with those in common patients. Renal dysfunction was more common in severe patients. By multivariate logistic regression, male, higher age and hypertension were three importantly independent risk factors of renal dysfunction in COVID-19 patients. Follow-up study found that at least one renal function marker of 3.33% patients remained abnormal in two weeks after discharge.
PMC7687494; Prediction on the number of confirmed Covid-19 with the FUDAN-CCDC mathematical model and its epidemiology, clinical manifestations, and prevention and treatment effects	Xiao,  S,  Cheng, et al	Results Phys	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Clinical data| Données cliniques	This study was to explore the development trend and clinical manifestations of COVID-19 better. The number of confirmed novel coronavirus pneumonia (COVID-19) was predicted based on the FUDAN-CCDC mathematical model. The FUDAN-CCDC model predicted that the peak time of cumulative confirmed cases in Wuhan was from February 1 to February 5, the peak of cumulative confirmed cases was around 60,000, and the peak time of newly confirmed cases was from February 8 to February 11. Most of the patients with COVID-19 in critical cases were older, with an average age of 65.31 ± 8.26 years old; it was mainly imported case (94 cases, 18.8%) at the beginning, and was mainly local cases (406 cases, 81.2%) later. The initial symptoms were fever (447 cases, 89.4%) and cough (304 cases, 60.8%), and the patients in severe and critical cases were often accompanied by respiratory failure and other late symptoms.
The role of resilience and gender in relation to infectious-disease-specific health literacy and anxiety during the covid-19 pandemic	Xiao,  X,  Xiao, et al	Neuropsychiatric Disease and Treatment	Mental Health | santé mentale	This study explored the relationship between infectious-disease-specific health literacy and anxiety. Most (63%) of the study participants experienced at least mild anxiety. The indirect effect of infectious-disease-specific health literacy on anxiety through resilience was −0.282, contributing to 32.7% of the total effect of health literacy on anxiety.
The usage of deep neural network improves distinguishing COVID-19 from other suspected viral pneumonia by clinicians on chest CT: a real-world study	Xie,  Q,  Lu, et al	Eur Radiol	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Based on the current clinical routine, we aimed to develop a novel deep learning model to distinguish coronavirus disease 2019 (COVID-19) pneumonia from other types of pneumonia and validate it with a real-world dataset (RWD). A three-dimensional DL model was successfully established. The diagnostic threshold to differentiate COVID-19 and non-COVID-19 pneumonia was 0.685 with an AUC of 0.906  in the internal validation group. In the RWD cohort, our model achieved an AUC of 0.868 with the sensitivity of 0.811 and the specificity of 0.822, non-inferior to the performance of 3 experienced radiologists, suggesting promising clinical practical usage.
Analysis of factors for disease progression in 61 patients with COVID-19 in Xiaogan, Hubei, China	Xing,  Y,  Wang, et al	European review for medical and pharmacological sciences	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim of this study was to retrospectively analyze clinical characteristics and laboratory results of the novel coronavirus pneumonia (COVID-19) patients so as to identify factors related to disease progression. On admission, significant differences were observed between the two groups with respect to the levels of Creatine Kinase (CK), lymphocytes, D-dimer and creatinine, and prothrombin time (PT). Univariate logistic regression analysis showed that Platelet-to-lymphocyte ratio (PLR), lymphocytes, Mean platelet volume to lymphocyte ratio (MPVLR), CK, White Blood count to mean platelet volume ratio (WMR), Lymphocyte-to-monocyte ratio (LMR), and serum creatinine were important factors for disease progression. Multivariate logistic regression analysis showed that PLR was an independent factor for disease progression in COVID-19 patients.
Modeling of Network Based Digital Contact Tracing and Testing Strategies for the COVID-19 Pandemic	Xu,  Daniel	arXiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	We developed a mathematical model to simulate the COVID-19 pandemic with digital contact tracing and testing strategies. The results show that the traditional strategy of quarantining direct contacts reduces infections by less than 20% without sufficient testing. Periodic testing every 2 weeks without contact tracing reduces infections by less than 3%. The most effective strategy discussed in this work was combined the pre-exposure notification system with testing second and third degree contacts. This strategy reduces infections by 18.3% when 30% of the population uses the app, 45.2% when 50% of the population uses the app, 72.1% when 70% of the population uses the app, and 86.8% when 95% of the population uses the app. When simulating the model on an extended network of 5000 students, the results are similar with the contact tracing app reducing infections by up to 79%.
Extensive High-Order Complexes within SARS-CoV-2 Proteome Revealed by Compartmentalization-Aided Interaction Screening	Xu,  Weifan,  Pei, et al	bioRxiv	Coronavirology| Coronavirologie	Here, we developed an innovative interaction screening strategy based on phase separation in cellulo, namely compartmentalization of protein-protein interactions in cells (CoPIC). We identified a total of 47 binary interactions among 14 proteins governing replication, discontinuous transcription, and translation of coronaviruses.
Single point mutations can potentially enhance infectivity of SARS-CoV-2 revealed by in silico affinity maturation and SPR assay	Xue,  Ting,  Wu, et al	bioRxiv	Coronavirology| Coronavirologie	Here we used an in-silico approach to predict how mutations on RBD affect its binding affinity to hACE2 (human angiotensin-converting enzyme2). The effect of all single point mutations on the interface was predicted. SPR assay result shows that 6 out of 9 selected mutations can strengthen binding affinity.
SARS-CoV-2 infecting the inner ear results in potential hearing damage at the early stage or prognosis of COVID-19 in rodents	Xue,  Xia,  Tian, et al	bioRxiv	Clinical data| Données cliniques Animal model | Modèle animal	In order to find out the association between the sensorineural hearing loss and COVID-19, we detected the expression ACE2 and TMPRSS2 in the mouse and the hamster. We identified ACE2 and TMPRSS2 expressed at different level in the inner ear and brain at DNA and transcriptomic levels of both mouse and the hamster. The protein expression shows a similar pattern of the brain and inner ear, while the expression of ACE2 from the inner ear was relatively higher than it from the muscle.
Design of Knowledge Graph of Traditional Chinese Medicine Prescription and Knowledge Analysis of Implicit Relationship	Yan,  C,  Qingyue, et al		Therapeutics| Thérapeutique	The FP-Growth algorithm was used to analyze the properties, tastes, and meridian tropism of Chinese medicinal herb groups in prescription data, constructing a knowledge graph for Covid-19 description and mining the prescription medication rules. Patients in medical observation period were treated with Chinese medicinal herbs that can relieve exterior syndromes and stop vomiting, such as Radix Saposhnikoviae, Semen Sojae Preparatum, etc. Those with mild common syndromes were treated with heat-clearing and detoxicating Chinese medicinal herbs, such as Rhizoma Coptidis, Radix Scutellariae, etc. Infected patients were treated with Chinese medicinal herbs such as Radix Glycyrrhizae, Herba Asari, etc., which can dissolve phlegm, relieve cough and invigorate the spleen, relieve pain, expel wind syndromes, relieve exterior symptoms and help digesting.
Five rapid scoring systems for predicting the mortality of severe novel coronavirus disease patient	Yan,  L,  Wang, et al	American Journal of Emergency Medicine	Epidemiology| Épidémiologie Clinical data| Données cliniques	We used the data from a tertiary hospital in China from March 7 to April 7 to evaluate its effectiveness of some other rapid predictive methods at admission that are also used in our clinic practice for the prediction of mortality risk in COVID-19 patients. We collected demographics, clinical manifestations, and laboratory results, to calculate these scoring systems together. From our research, we found that SOFA is most accuracy but complex. In rapid scoring systems, the result shows that the maximum area under the curve (AUC) was REMS, followed by NEWS, HEWS, qSOFA. qSOFA.
Are the SIR and SEIR models suitable to estimate the basic reproduction number for the CoViD-19 epidemic?	Yang,  Hyun Mo,  Lombardi Junior, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission	We proposed a more elaborate model considering the natural history of CoViD-19: the inclusion of asymptomatic, pre-symptomatic, mild and severe CoViD-19 compartments. The model also encompassed the fatality rate depending on age. This SEAPMDR model estimated R0 using the severe CoViD-19 data from São Paulo State (Brazil) and Spain, yielding higher values for R0, that is, 6.54 and 5.88, respectively.
Changes in Compliance and Knowledge of Infection Prevention and Control Practices Following the COVID-19 Outbreak: A Retrospective Study of 197 non-frontline Healthcare Workers	Yang,  L,  Alamgir, et al	Dermatol Ther	Healthcare Response | Réponse des soins de santé	The questionnaire surveyed the knowledge of HCWs, training frequency, and adherence to IPC policies under different settings: pre-outbreak, post-outbreak/pre-frontline deployment, and post-frontline deployment.  Compliance with and knowledge of IPC practices improved significantly post-outbreak compared to pre-outbreak, and after working at the frontline. Of note, the biggest improvement in scores was in knowledge regarding the correct donning and doffing procedures for PPE. The majority of HCWs (30%) considered field experience to be the most beneficial form of training amongst the various training settings.
Effectiveness of Non-pharmaceutical Interventions to Contain COVID-19: A Case Study of the 2020 Spring Pandemic Wave in New York City	Yang,  Wan,  Shaff, et al	medRxiv	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	Using detailed epidemiological and mobility data available for New York City and comprehensive modeling accounting for under-detection, we reconstruct the COVID-19 transmission dynamics therein during the 2020 spring pandemic wave and estimate the effectiveness of two major non-pharmaceutical interventions—lockdown-like measures that reducing contact rates and universal masking.  Lockdown-like measures were associated with >50% transmission reduction for all age groups. Universal masking was associated with a ∼7% transmission reduction overall and up to 20% reduction for 65+ year-olds during the first month of implementation.
A convalescent of COVID-19 with RT-PCR test continues positive in stool	Yang,  Z,  Yu, et al	Clinical laboratory	Clinical data| Données cliniques	We present a patient with COVID-19, whose respiratory swabs became negative but fecal sample remained positive for SARS-CoV-2 RNA. Stool sample collected on 27th of February was still positive for SARS-CoV-2 RNA, 24 days after the first negative respiratory swab.
The clinical characteristics and prognosis of COVID-19 patients with cerebral stroke: A retrospective study of 113 cases from one single-centre	Yao,  X,  Liu, et al	European Journal of Neuroscience	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objective was to explore the clinical characteristics and prognosis of COVID-19 patients with cerebral stroke. Of the 2,474 COVID-19 patients, 113 (4.7%) patients had cerebral stroke and 25 (1.0%) patients had new-onset stroke. Most COVID-19 patients with stroke were elderly with more comorbidities such as hypertension, diabetes and heart diseases than patients without stroke. Laboratory examinations showed hypercoagulation and elevated serum parameters such as IL-6, cTnI, NT pro-BNP and BUN. Consciousness disorders, a long disease course and poor prognosis were also more commonly observed in stroke patients. The mortality rate of stroke patients was almost double (12.4% vs. 6.9%) that of patients without stroke.
PMC7674113; Changes in Advance Care Planning for Nursing Home Residents During the COVID-19 Pandemic	Ye,  P,  Fry, et al	J Am Med Dir Assoc	Healthcare Response | Réponse des soins de santé	OBJECTIVE: Describe the care preference changes among nursing home residents receiving proactive Advance Care Planning (ACP) conversations from health care practitioners during the COVID-19 pandemic.  Of the individuals with Out of Hospital DNR, 188 residents also chose DNH. After the ACP conversation, 88 residents opted to change from full code status to Out of Hospital DNR, thereby increasing the percentage of residents with Out of Hospital DNR from 63% to 72%. Almost half of the residents decided to keep or change to the DNH care option after the ACP conversation.
Mesenchymal stem cells treatment in COVID-19 patient with multi-organ involvement	Yilmaz,  R,  Adas, et al	Bratislavske lekarske listy	Clinical data| Données cliniques	Here, a 51-year-old male patient with multi-organ involvement due to COVID-19 infection and developing cardiac arrest is presented. MSCs were transplanted to the patient four times systematically and once intrathecally. As a result, the application of MSCs has been found to have a healing effect on organs in this patient with severe COVID-19 infection
Effect of pandemic-related confinement on vitamin D status among children aged 0–6 years in Guangzhou, China: A cross-sectional study	Yu,  L,  Ke, et al	Risk Management and Healthcare Policy	Healthcare Response | Réponse des soins de santé	This study aimed to examine the effect of COVID-19 measures on 25(OH)D levels in children. The mean serum 25(OH)D level was 84 ± 25nmol/L. Home confinement led to an increase in the proportion of children aged 3– 6 years with vitamin D deficiency during March 1–June 30, 2020 compared with the same months in previous years, and the most noticeable increase was found in March 2020.
A survey of psychological responses during the coronavirus disease 2019 (Covid-19) epidemic among chinese police officers in wuhu	Yuan,  L,  Zhu, et al	Risk Management and Healthcare Policy	Mental Health | santé mentale	The main purpose of this study was to assess the prevalence and severity of psychological responses among police officers during the COVID-19 pandemic and find influencing factors in depression and anxiety. The mean depression score of participants was 4.10±4.87 (0–27), and 12.17%had moderate–severe depression. The mean anxiety score of participants was 3.59±4.228 (0–21), and 8.79% had moderate–severe anxiety. Older and married police officers were at higher risk of anxiety. Those with a bachelor’s degree or above, living near the city center, and taking sleeping pills were at greater risk of depression and anxiety.
Successful management of a patient with active Cushing's disease complicated with coronavirus disease 2019 (COVID-19) pneumonia	Yuno,  A,  Kenmotsu, et al	Endocr J	Clinical data| Données cliniques	The patient was a 27-year-old Japanese female healthcare worker who was scheduled to undergo pituitary surgery for Cushing's disease. She had been in close contact with an undiagnosed patient infected with COVID-19 and then developed COVID-19 pneumonia.
Association of Personal Protective Equipment with De Novo Headaches in Frontline Healthcare Workers during COVID-19 Pandemic: A Cross-Sectional Study	Zaheer,  R,  Khan, et al	Eur J Dent	Healthcare Response | Réponse des soins de santé	This study aimed to determine the association of personal protective equipment (PPE) usage with new-onset headaches and exacerbation of pre-existing headache disorders among healthcare workers at the frontlines during coronavirus disease 2019 (COVID-19) pandemic. A total of 241 healthcare workers participated, of which 68 participants (28.2%) reported de novo headaches since the start of the pandemic. Post hoc multivariable logistic regression analysis stated that incidence of pre-existing headaches and age was independently associated with new-onset PPE-induced headaches but was not statistically significant.
Prevalence and Clinical Impact of Sars-CoV-2 Silent Carriers Among Actively Treated CANCER Patients During The COVID-19 Pandemic	Zambelli,  A,  Chiudinelli, et al	Oncologist	Epidemiology| Épidémiologie Immunology | Immunologie	We implemented a two-step diagnostics, including the rapid serological immunoassay for anti-SARS-CoV-2 IgG/IgM and the nasopharyngeal swab RT-PCR test in case of seropositivity to identify SARS-CoV-2 silent carriers. In 560 patients, 172 (31%) resulted positive for anti-SARS-CoV-2 IgM/IgG antibodies, regardless of different type of cancer, stage, and anticancer treatment. The Ig-seropositive patients were then tested with RT-PCR nasopharyngeal swabs, and 38% proved to be SARS-CoV-2 silent carriers. Testing only in case of seropositivity magnified the SARS-CoV-2 silent carriers detection and predicted an RT-PCR number-needed-to-test calculation of 2.5, versus 10 for testing the whole population with RT-PCR.
Neuropsychologists' practice adjustments: the impact of COVID-19	Zane,  KL,  Thaler, et al	Clin Neuropsychol	Mental Health | santé mentale Healthcare Response | Réponse des soins de santé	The current study aimed to further characterize the change in neuropsychologists' professional practice, specifically related to teleneuropsychology (TNP) service provision, and also provide novel data regarding the impact of the pandemic on providers' emotional health. On average, respondents reported a medium amount of distress/anxiety related to COVID-19, which had a "somewhat small impact" on their ability to practice overall.
Efficacy of Traditional Chinese Medicine, Maxingshigan-Weijing in the management of COVID-19 patients with severe acute respiratory syndrome: A structured summary of a study protocol for a randomized controlled trial	Zeng,  C,  Yuan, et al	Trials	RCT	We aimed to test our expectation that additional administration of Traditional Chinese medicine (TCM), maxingshigan-weijing decoction, is more effective in the management of COVID-19 patients compared to those treated with routine supportive care alone
Quantitative assessment of the effects of resource optimization and ICU admission policy on COVID-19 mortalities	Zeng,  Ying-Qi,  Zeng, et al	ArXiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	We develop a comprehensive, non-Markovian state transition model, which is validated through accurate prediction of the daily death toll for two epicenters: Wuhan, China and Lombardy, Italy. The model enables prediction of COVID-19 deaths in various scenarios. For example, if treatment priorities had been given to younger patients, the death toll in Wuhan and Lombardy would have been reduced by 10.4\% and 6.7\%, respectively
Serum-soluble ST2 as a novel biomarker reflecting inflammatory status and illness severity in patients with COVID-19	Zeng,  Z,  Hong, et al	Biomarkers in Medicine	Epidemiology| Épidémiologie Clinical data| Données cliniques	The authors studied the role of soluble ST2 (sST2) in COVID-19 and its relationship with inflammatory status and disease severity. Serum sST2 levels were significantly increased in COVID-19 patients, which were positively correlated with CRP, but negatively correlated with CD4+ and CD8+ T lymphocyte counts. Serum sST2 levels in nonsurviving severe cases were persistently high during disease progression.
General Model for COVID-19 spreading with consideration of intercity migration, insufficient testing, and active intervention: Modeling study of pandemic progression in Japan and the United States	Zhan,  C,  Tse, et al	JMIR Public Health and Surveillance	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	This study aims to develop a new susceptible-exposed-infected-confirmed-removed (SEICR) model for predicting the spreading progression of COVID-19 with consideration of intercity travel and the difference between the number of confirmed cases and actual infected cases, and to apply the model to provide a realistic prediction for the United States and Japan under different scenarios of active intervention. The model revealed that, as of March 19, 2020, the number of infected individuals in Japan and the United States could be 20-fold and 5-fold as many as the number of confirmed cases, respectively. The results showed that, without tightening the implementation of active intervention, Japan and the United States will see about 6.55% and 18.2% of the population eventually infected, respectively, and with a drastic 10-fold elevated active intervention, the number of people eventually infected can be reduced by up to 95% in Japan and 70% in the United States.
Americans' perceptions of privacy and surveillance in the COVID-19 pandemic	Zhang,  B,  Kreps, et al	PLoS One	Public Health response| Interventions de santé publique	OBJECTIVE: To study the U.S. public's attitudes toward surveillance measures aimed at curbing the spread of COVID-19, particularly smartphone applications (apps) that supplement traditional contact tracing. RESULTS: A smaller percentage of respondents support the government encouraging everyone to download and use contact tracing apps (42%) compared with other surveillance measures such as enforcing temperature checks (62%), expanding traditional contact tracing (57%), carrying out centralized quarantine (49%), deploying electronic device monitoring (44%), or implementing immunity passes (44%).
Association between Use of Qingfei Paidu Tang and Mortality in Hospitalized Patients with COVID-19: A national retrospective registry study	Zhang,  Lihua,  Zheng, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique	We aimed to explore the association between QPT use and in-hospital mortality among patients hospitalized for COVID-19. The crude mortality was 1.2%  among the patients receiving QPT and 4.8% among those not receiving QPT. After adjustment for patient characteristics and concomitant treatments, QPT use was associated with a relative reduction of 50% in in-hospital mortality. This association was consistent across subgroups by sex and age. Meanwhile, the incidence of acute liver injury and acute kidney injury was comparable between patients receiving QPT and those not receiving QPT.
Biomimetic Human Disease Model of SARS-CoV-2-Induced Lung Injury and Immune Responses on Organ Chip System	Zhang,  M,  Wang, et al	Advanced Science	Clinical data| Données cliniques Immunology | Immunologie	Here, a biomimetic human disease model on chip that allows to recapitulate lung injury and immune responses induced by SARS-CoV-2 in vitro at organ level is created. Treatment with remdesivir can inhibit viral replication and alleviate barrier disruption on chip. This organ chip model can closely mirror human-relevant responses to SARS-CoV-2 infection, which is difficult to be achieved by in vitro models, providing a unique platform for COVID-19 research and drug development.
Application of Remote Follow-Up Via the WeChat Platform for Patients who Underwent Congenital Cardiac Surgery During the COVID-19 Epidemic	Zhang,  QL,  Huang, et al	Braz J Cardiovasc Surg	Healthcare Response | Réponse des soins de santé	To investigate the effect of WeChat-based telehealth services on the postoperative follow-up of children who underwent congenital heart surgery during the COVID-19 epidemic. The use of WeChat-based telehealth services was effective for the remote postoperative follow-up of children who underwent congenital cardiac surgery during the COVID-19 epidemic.
Analysis of Blocking Population Flow to Control COVID-19 in Multi-regions Based on Discrete SEIR Epidemic Model	Zhang,  S		Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	This research uses SEIR model to simulate the flow between regions with input of the data from three regions, and each region has regional parametric variation. There are two main findings. First, controlling the population flow between two similar regions (with similar contact rate, total population, etc.) has little effect and is a waste of resources. Second, controlling population flow in and out of the region that has low contact rate (or infectious rate) and larger population can help delay the outbreak of virus in that region and keep safe resources for the other regions at the same time.
The UK media coverage of China’s handling of the coronavirus outbreak	Zhang,  X,  Shaw, et al	Global Media and China	Public Health response| Interventions de santé publique	This article addresses one question: how is the coronavirus outbreak and its management in China reported in the UK media in general, and on the Internet in particular? It does so by examining how the online versions of the BBC, the Guardian and the Daily Mail reported on the coronavirus outbreak in China, but more importantly, on how China handled it, over a 20-week timeframe. The sentiment analysis and thematic analysis show that although the selected media are of different types in the United Kingdom, the themes and topics are not substantially different from each other.
Analysis and validation of a highly sensitive one-step nested quantitative real-time polymerase chain reaction assay for specific detection of severe acute respiratory syndrome coronavirus 2	Zhang,  Y,  Dai, et al	Virol J	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In this study, we aimed to analyze OSN-qRT-PCR by comparing it with droplet digital PCR (ddPCR) and qRT-PCR by using a dilution series of SARS-CoV-2 pseudoviral RNA and a quality assessment panel. The limit of detection (copies/ml) of qRT-PCR, ddPCR, and OSN-qRT-PCR were 520.1 for ORF1ab and 528.1 for N, 401.8  for ORF1ab and 336.8 for N, and 194.74 for ORF1ab and 189.1 for N, respectively. Of the 34 clinical samples from COVID-19 patients, the positive rates of OSN-qRT-PCR, ddPCR, and qRT-PCR were 82.35% (28/34), 67.65% (23/34), and 58.82% (20/34), respectively.
Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19	Zheng,  HY,  Xu, et al	Signal Transduct Target Ther	Immunology | Immunologie	Here, we performed longitudinal whole-transcriptome RNA sequencing on peripheral blood mononuclear cell (PBMC) samples from 18 patients with coronavirus disease 2019 (COVID-19) during their treatment, convalescence, and rehabilitation. We found that humoral immunity and type I interferon response were significantly downregulated, while robust T-cell activation and differentiation at the whole transcriptome level constituted the main events that occurred during recovery from COVID-19. The formation of this T cell immune response might be driven by the activation of activating protein-1 (AP-1) related signaling pathway and was weakly affected by other clinical features.
A Neanderthal OAS1 isoform Protects Against COVID-19 Susceptibility and Severity: Results from Mendelian Randomization and Case-Control Studies	Zhou,  Sirui,  Butler-Laporte, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	To identify circulating proteins influencing COVID-19 susceptibility and severity we undertook a large-scale two-sample Mendelian randomization (MR) study, since this study design can rapidly scan hundreds of circulating proteins and reduces bias due to reverse causation and confounding.  We found that a standard deviation increase in OAS1 levels was associated with reduced COVID-19 death or ventilation, COVID-19 hospitalization and COVID-19 susceptibility. Increased OAS1 levels in a non-infectious state were associated with protection against very severe COVID-19, hospitalization and susceptibility. Further analyses suggested that a Neanderthal isoform of OAS1 affords this protection
PMC7738279; Temperature dependence of the SARS-CoV-2 affinity to human ACE2 determines COVID-19 progression and clinical outcome	Zhou,  Z,  Yang, et al	Comput Struct Biotechnol J	Coronavirology| Coronavirologie	In this study, our molecular dynamics simulation and protein surface plasmon resonance cohesively proved the SARS-CoV-2-ACE2 binding was less affinitive and stable under 40 °C than the optimum temperature 37 °C, while SARS-CoV-ACE2 binding was not, which evidenced the temperature-dependent affinity and explained that higher temperature is related to better clinical outcome.
Effect of methylprednisolone in severe and critical COVID-19: Analysis of 102 cases	Zhu,  HM,  Li, et al	World Journal of Clinical Cases	Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique	Comparison of baseline data between the two groups showed that the treatment group patients had higher aspartic acid aminotransferase, globulin, hydroxybutyrate dehydrogenase, and lactate dehydrogenase. There was no significant difference in other baseline data between the two groups. With regard to prognosis, 29 (78.4%) patients in the treatment group died as opposed to 40 (61.5%) in the control group. Methylprednisolone treatment does not improve prognosis in severe and critical COVID-19 patients
SARS-CoV-2 serologic immune response in exogenously immunosuppressed patients	Zilla,  ML,  Keetch, et al	J Appl Lab Med	Clinical data| Données cliniques Immunology | Immunologie	In this report, we follow the anti-SARS-CoV-2 antibody levels in patients with COVID-19 who are undergoing exogenous immunosuppression. We found that the solid organ transplant patients on full immunosuppression are at risk of having a delayed antibody response and poor outcome. We did not find evidence that inhaled steroids nor etanercept predispose patients to delayed immune response to SARS-CoV-2.
Investigation of coronavirus deposition in realistic human nasal cavity and impact of social distancing to contain COVID-19: A computational fluid dynamic approach	Zuber,  M,  Corda, et al	CMES - Computer Modeling in Engineering and Sciences	Transmission Public health interventions*| Interventions de sant&amp;eacute; publique	This study is performed using Computational Fluid Dynamics as a solution tool to investigate the impact of COVID-19 deposition (i) On a realistic 3D human upper airway model and (ii) 2D social distancing protocol for a distance of 0.6, 1.2, 1.8, and 2.4 m. The results revealed that the regional deposition flux within the nasal cavity was predominantly observed in the external nasal cavity and nasopharyngeal section. Frequent flushing of these regions with saltwater substitutes can limit contamination in healthy individuals. The safe distancing limit estimated with 1 m/s airflow was about 1.8 m.
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships	Abate,  C,  Niso, et al	Frontiers in Pharmacology	Review Literature| Revue de littérature
Filtration mechanisms and manufacturing methods of face masks: An overview	Adanur,  S,  Jayswal, et al	Journal of Industrial Textiles	Review Literature| Revue de littérature
Renin-Angiotensin system implications to COVID-19 comorbidities	Alsufyani,  H,  Alrefaie, et al	Journal of Microscopy and Ultrastructure	Review Literature| Revue de littérature
Analysis of UV technologies for disinfection of public areas: A systematic literature review	Alvarado-Miranda,  L,  Zea-Palomino, et al		Review Literature| Revue de littérature	SR: In the present investigation 34 scientific articles were synthesized, taken from databases such as: Scopus/Elsevier, ScienceDirect, IEEE Xplore, Researchgate. Of these, 39% are oriented towards the health area and 21 % are used in the disinfection of public areas. In conclusion, the rates of use of this germicide and how to sterilize by means of ultraviolet radiation were announced.
A review of the prevalence of COVID-19 in the Arab world	Alwahaibi,  N,  Al-Maskari, et al	Journal of infection in developing countries	Review Literature| Revue de littérature
Virtual Care for Neurological Practice	Appireddy,  R,  Bendahan, et al	Annals of Indian Academy of Neurology	Review Literature| Revue de littérature
Cognitive defect and covid-19	Araújo,  JM,  Branco, et al	Sinapse	Review Literature| Revue de littérature
Corona virus-an overview	Aravindha Babu,  N,  Sridevi Anjuga, et al	Indian Journal of Forensic Medicine and Toxicology	Review Literature| Revue de littérature
Infection control during COVID – 19 (Corona virus)	Aravindha Babu,  N,  Sridevi Anjuga, et al	Indian Journal of Forensic Medicine and Toxicology	Review Literature| Revue de littérature
Phosphatidylserine inside out: a possible underlying mechanism in the inflammation and coagulation abnormalities of COVID-19	Argañaraz,  GA,  Palmeira, et al	Cell Commun Signal	Review Literature| Revue de littérature
Association of COVID-19 and other viral infections with interstitial lung diseases, pulmonary fibrosis, and pulmonary hypertension: A narrative review	Atabati,  E,  Dehghani-Samani, et al	Canadian Journal of Respiratory Therapy	Review Literature| Revue de littérature
The Importance and Challenges of Identifying SARS-CoV-2 Reinfections	Babiker,  A,  Marvil, et al	J Clin Microbiol	Review Literature| Revue de littérature
Prevalence, clinical characteristics, and outcomes of pediatric COVID-19: A systematic review and meta-analysis	Badal,  S,  Thapa Bajgain, et al	Journal of Clinical Virology	Review Literature| Revue de littérature	SR-MA: PubMed, Embase, Scopus, Medline, and Google Scholar databases were searched. All relevant studies until June 16, 2020 were included. COVID-19 is prevalent across all pediatric age-groups and presents with varying degree of symptomology. However, children have a milder course of the disease with extremely favorable prognosis.
Hydroxychloroquine toxicity management: A literature review in COVID-19 era	Bakhsh,  H	Journal of Microscopy and Ultrastructure	Review Literature| Revue de littérature
Call for Action to Address Equity and Justice Divide During COVID-19	Bhaskar,  S,  Rastogi, et al	Frontiers in Psychiatry	Review Literature| Revue de littérature
ABO blood groups and severe outcomes in COVID-19: A meta-analysis	Bhattacharjee,  S,  Banerjee, et al	Postgrad Med J	Review Literature| Revue de littérature	MA: earch of the literature across the PubMed database from inception till 30 November 2020. In conclusion, this preliminary, yet updated meta-analysis negates the possible significant association between the lack of anti-A antibodies (A/AB blood group), and poor clinical outcomes in patients with COVID-19.
COVID-19 and Neutrophils: The relationship between hyperinflammation and neutrophil extracellular traps	Borges,  L,  Pithon-Curi, et al	Mediators of inflammation	Review Literature| Revue de littérature
Provision of health care for prisoners during the COVID-19 pandemic: an ethical analysis of challenges and summary of select best practices	Brelje,  AB,  Pinals, et al	International Journal of Prisoner Health	Review Literature| Revue de littérature
Mortality of patients with COVID-19 who undergo an elective or emergency surgical procedure: a systematic review and meta-analysis	Brown,  WA,  Moore, et al	ANZ J Surg	Review Literature| Revue de littérature	SR-MA: search was undertaken using electronic bibliographic databases MEDLINE, EMBASE, PubMed and Cochrane Library to identify eligible studies published from 1 November 2019 until 21 August 2020. This meta-analysis confirms that concurrent COVID-19 infection increases the risk of surgical mortality. The magnitude of this risk mandates that strategies are developed to mitigate the risk at both an individual and system level.
PMC7665639; Aetiology of fever in returning travellers and migrants: a systematic review and meta-analysis	Buss,  I,  Genton, et al	J Travel Med	Review Literature| Revue de littérature	SR-MA: Embase, MEDLINE and Cochrane Library were searched. Malaria accounted for one-fifth of febrile cases, highlighting the importance of rapid malaria testing in febrile returning travellers, followed by other rapid tests for common tropical diseases. High variability between studies highlights the need to harmonize study designs and to promote multi-centre studies investigating predictors of diseases, including of lower incidence, which may help to develop evidence-based guidelines. The use of clinical decision support algorithms by health workers which incorporate clinical predictors, could help standardize studies as well as improve quality of recommendations.
Systematic Review of Telehealth Cost Minimization for Patients and Health Systems in Otolaryngology	Cabrera,  CI,  Ning, et al	Laryngoscope	Review Literature| Revue de littérature	SR: systematic review using PubMed, EMBASE, and Cochrane in May 2020. Telemedicine has been trialed across various otolaryngology subspecialties; its incorporation is projected to have a meaningful impact on access to specialty care. This research suggests that the delivery of virtual care reduces cost with the potential of increasing net revenue across multiple otolaryngology subspecialties.
Detection of Viral Infections by Innate Immunity	Carty,  M,  Guy, et al	Biochem Pharmacol	Review Literature| Revue de littérature
The immune system view of the coronavirus SARS-CoV-2	Celardo,  I,  Pace, et al	Biol Direct	Review Literature| Revue de littérature
Profiling severe acute respiratory syndrome coronavirus 2 and its relevance to otolaryngologic examinations during the coronavirus disease 2019 pandemic	Chan,  CPL,  Chan, et al	Curr Opin Allergy Clin Immunol	Review Literature| Revue de littérature
How Satisfied Are Patients and Surgeons with Telemedicine in Orthopaedic Care During the COVID-19 Pandemic? A Systematic Review and Meta-analysis	Chaudhry,  H,  Nadeem, et al	Clin Orthop Relat Res	Review Literature| Revue de littérature	SR-MA: searched three medical databases (MEDLINE, Embase, and the Cochrane Library). Evidence from heterogeneous randomized studies demonstrates that the use of telemedicine for orthopaedic assessments does not result in identifiable differences in patient or surgeon satisfaction compared with in-person assessments. Importantly, the source studies in this review did not adequately capture or report safety endpoints, such as complications or missed diagnoses.
2020: Mexican urology in times of COVID-19. A literature review and COVID-19 pandemic update for urologists	Chein-Vázquez,  MF,  Tarot-Chocooj, et al	Revista mexicana de urologia	Review Literature| Revue de littérature
PMC7577277; Phase-3 Randomized Controlled Trials on Exclusion of Participants With Kidney Disease in COVID-19	Chewcharat,  A,  Chang, et al	Kidney Int Rep	Review Literature| Revue de littérature
Roadmap: one anesthesiology department's strategic approach to COVID-19	Coombs,  AAT,  Lawson, et al	Curr Opin Anaesthesiol	Review Literature| Revue de littérature
A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2	Das,  M,  Kumar, et al	Curr Drug Targets	Review Literature| Revue de littérature
Social and Biological Parameters Involved in Suicide Ideation During the COVID-19 Pandemic: A Narrative Review	Dhrisya,  C,  Prasathkumar, et al	International Journal of Tryptophan Research	Review Literature| Revue de littérature
Facial Surgery in the Era of SARS-CoV-2 and Beyond: Challenges, Considerations, and Initiatives	Dicaro,  MV,  Mintz, et al	Plastic and Reconstructive Surgery - Global Open	Review Literature| Revue de littérature
The Politics of Pandemic Othering: Putting COVID-19 in Global and Historical Context	Dionne,  KY,  Turkmen, et al	International Organization	Review Literature| Revue de littérature
Potential therapeutic role of purinergic receptors in cardiovascular disease mediated by SARS-CoV-2	Dos Anjos,  F,  Simões, et al	Journal of Immunology Research	Review Literature| Revue de littérature
Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS-CoV-2 in the respiratory tract	El-Shimy,  I,  Mohamed, et al	Pharmacol Res Perspect	Review Literature| Revue de littérature
Artificial intelligence in COVID-19 ultrastructure	Elwazir,  M,  Hosny, et al	Journal of Microscopy and Ultrastructure	Review Literature| Revue de littérature
Challenges in COVID-19 diagnosis	Erenler,  AK,  Baydin, et al	Bratislavske lekarske listy	Review Literature| Revue de littérature
Covid-19 and acute kidney injury: A systematic review and meta-analysis	Fabrizi,  F,  Alfieri, et al	Pathogens	Review Literature| Revue de littérature	SR-MA: AKI is a common complication in hospitalized COVID-19 positive patients.
COVID-19 and Socioeconomic Crises in Africa: Overview of the Prevailing Incidents	Fagbemi,  Fisayo,  Asongu, et al	SSRN- Lancet prepublication	Review Literature| Revue de littérature
PMC7716651; Current directions, conceptions and viewpoints on 2019-nCoV (Review)	Feng,  X,  Xie, et al	Exp Ther Med	Review Literature| Revue de littérature
Drug interactions for elderly with respiratory disorders and times of covid-19: A systematic scoping review	Forgerini,  M,  Schiavo, et al	Vitae	Review Literature| Revue de littérature	ScR: review was conducted until February 2020. Considering the increased risk of COVID-19 infection in the elderly, drug interactions and the use of potentially inappropriate medication associated with the occurrence of adverse drug events in the respiratory system may also worsening COVID-19 infection in patients with uncontrolled respiratory disorders.
ACE2 as a potential target for management of novel coronavirus (nCoV- 2019)	Foroozanfar,  E,  Forouzanfar, et al	Curr Drug Discov Technol	Review Literature| Revue de littérature
COVID-19 and radiotherapy: Potential new strategies for patients management with hypofractionation and telemedicine	Franco,  RDI,  Borzillo, et al	European review for medical and pharmacological sciences	Review Literature| Revue de littérature
Academic Library COVID-19 Subject Guides	Fraser-Arnott,  M	Reference Librarian	Review Literature| Revue de littérature
Selection of the best of 2020 in cardiac arrhythmias	García Seara,  J,  Martínez Sande, et al	REC: CardioClinics	Review Literature| Revue de littérature
QT Interval Monitoring and Drugs Management During COVID-19 Pandemic	Gasperetti,  A,  Schiavone, et al	Curr Clin Pharmacol	Review Literature| Revue de littérature
Natural history of COVID-19 and therapeutic options	Gautret,  P,  Million, et al	Expert Rev Clin Immunol	Review Literature| Revue de littérature
Drug discovery of small molecules for the treatment of COVID-19: A review on clinical studies	Goel,  B,  Bhardwaj, et al	Mini Rev Med Chem	Review Literature| Revue de littérature
Experiences and needs of nursing students during pandemic outbreaks: A systematic overview of the literature	Goni-Fuste,  B,  Wennberg, et al	Journal of Professional Nursing	Review Literature| Revue de littérature
A systematic review on the investigation of sars-cov-2 in semen	Gonzalez,  DC,  Khodamoradi, et al	Research and Reports in Urology	Review Literature| Revue de littérature	SR:  literature search of the PubMed, Embase, Cochrane, Web of Science, Google Scholar, and Ovid databases was performed for articles from the dates of their inception to August 2020. The novel nature of SARS-CoV-2 has limited the number and size of studies on semen. Nevertheless, the current literature, while limited, has confirmed the presence of SARS-CoV-2 in semen in one out of the eight reported studies and totaling 4.3% of the population screened. Taken together, the risk of the presence of SARS-CoV-2 in semen appears to be extremely low and likely negligible in recovered men.
Herbal medicine, a reliable support in COVID therapy	Grigore,  A,  Cord, et al	J Immunoassay Immunochem	Review Literature| Revue de littérature
COVID in obstetrics: labor analgesia and cesarean section	Guasch,  E,  Brogly, et al	Curr Opin Anaesthesiol	Review Literature| Revue de littérature
Sars-cov-2, covid-19 and epilepsy	Guimarães,  P,  Coelho, et al	Sinapse	Review Literature| Revue de littérature
The potential of ODFs as carriers for drugs/vaccines against COVID-19	Gupta,  MS,  Kumar, et al	Drug development and industrial pharmacy	Review Literature| Revue de littérature
COVID-19 Vaccine: Critical Questions with Complicated Answers	Haidere,  MF,  Ratan, et al	Biomol Ther (Seoul)	Review Literature| Revue de littérature
An Overview on COVID-19 and its Effect on Cardiovascular Diseases	Hamadi,  A,  Mahzari, et al	Endocr Metab Immune Disord Drug Targets	Review Literature| Revue de littérature
GeoSentinel: past, present and future†	Hamer,  DH,  Rizwan, et al	J Travel Med	Review Literature| Revue de littérature
Challenges in COVID-19 drug treatment in patients with advanced liver diseases: A hepatology perspective	Hanafy,  AS,  Abd-Elsalam, et al	World Journal of Gastroenterology	Review Literature| Revue de littérature
Risk-adapted adjuvant therapy of luminal early breast cancer in 2020	Harbeck,  N	Curr Opin Obstet Gynecol	Review Literature| Revue de littérature
Targeting inflammatory cytokine storm to fight against COVID-19 associated severe complications	Hirawat,  R,  Saifi, et al	Life Sci	Review Literature| Revue de littérature
The impact of death and dying on the personhood of medical students: a systematic scoping review	Ho,  CY,  Kow, et al	BMC Med Educ	Review Literature| Revue de littérature	ScR: analysis of data from six databases (Split Approach) enhances the transparency and reproducibility of this review. Facing death and dying amongst their patients affect how medical students envisage their personhood. This underlines the need for timely, holistic and longitudinal support systems to ensure that problems faced are addressed early. To do so, there must be effective training and a structured support mechanism.
Targeting polyamine metabolism for control of human viral diseases	Huang,  M,  Zhang, et al	Infection and Drug Resistance	Review Literature| Revue de littérature	SR
Dental Care Implications in Coronavirus Disease-19 Scenario: Perspectives	Janakiram,  C,  Nayar, et al	Journal of Contemporary Dental Practice	Review Literature| Revue de littérature
Biomaterials-Based Opportunities to Engineer the Pulmonary Host Immune Response in COVID-19	Jarai,  BM,  Stillman, et al	ACS Biomater Sci Eng	Review Literature| Revue de littérature
Research progress on DNA vaccines against SARS-CoV-2	Jin,  X,  Yu, et al	Chinese Journal of New Drugs	Review Literature| Revue de littérature
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches	Jin,  Y,  Ji, et al	Signal Transduct Target Ther	Review Literature| Revue de littérature
Scoping Review: What Is the Role of Nurses in the Era of the Global COVID-19 Pandemic?	Kako,  J,  Kajiwara, et al	Journal of palliative medicine	Review Literature| Revue de littérature	ScR
Gout Pharmacotherapy in Cardiovascular Diseases: A Review of Utility and Outcomes	Kaul,  S,  Gupta, et al	Am J Cardiovasc Drugs	Review Literature| Revue de littérature
Remdesivir and Hydroxychloroquine: A Compassionate Use in Covid-19	Kaur,  A,  Chaudhary, et al	Curr Drug Targets	Review Literature| Revue de littérature
Naturally Occurring Animal Coronaviruses as Models for Studying Highly Pathogenic Human Coronaviral Disease	Kenney,  SP,  Wang, et al	Vet Pathol	Review Literature| Revue de littérature
COVID-19 ventilator rationing protocols: why we need to know more about the views of those with most to lose	Kerr,  W,  Schmidt, et al	J Med Ethics	Review Literature| Revue de littérature
Different aspects of convalescent plasma therapy for COVID-19 treatment; a critical review	Khadka,  S,  Nisar, et al	Immunopharmacol Immunotoxicol	Review Literature| Revue de littérature
Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites	Khan,  T,  Khan, et al	Biocatalysis and Agricultural Biotechnology	Review Literature| Revue de littérature
Could glutathione depletion be the Trojan horse of COVID-19 mortality?	Khanfar,  A,  Qaroot, et al	European review for medical and pharmacological sciences	Review Literature| Revue de littérature
Lung ultrasound in children with respiratory tract infections: Viral, bacterial or covid-19? a narrative review	Kharasch,  S,  Duggan, et al	Open Access Emergency Medicine	Review Literature| Revue de littérature
A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis	Khatami,  F,  Saatchi, et al	Sci Rep	Review Literature| Revue de littérature	MA: Three main databases; PubMed (MEDLINE), Scopus, and EMBASE were systematically searched for all published literature from January 1st, 2019, to the 21st May 2020. Regarding the overall diagnostic sensitivity of 87% for chest CT, the RT-PCR testing is essential and should be repeated to escape misdiagnosis.
Biological functions of MAIT cells in tissues	Klenerman,  P,  Hinks, et al	Mol Immunol	Review Literature| Revue de littérature
Severe Acute Respiratory Syndrome Coronavirus 2 and Coronavirus Disease 2019: A Clinical Overview and Primer	Knight,  TE	Biopreservation and Biobanking	Review Literature| Revue de littérature
SARS-Cov-2 infection in transplant-related biology: Where do we stand?	Kong,  D,  Li, et al	Ann Transplant	Review Literature| Revue de littérature
Addressing the issue of СOVID-19, SARS-CoV-2 virus and the disease	Korenkova,  AA,  Mayorova, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Review Literature| Revue de littérature
The great camoufleur: Covid-19 skin lesions in children	Korotkiy,  NG,  Botkina, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Review Literature| Revue de littérature
Susceptibility of people vaccinated against s. Pneumoniae to sars-cov-2 – mechanisms of non-specific action of pneumococcal vaccine	Kostinov,  AM,  Kostinov, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Review Literature| Revue de littérature
Features of the course of the new coronavirus infection (Sars-cov-2) in children	Kuznik,  BI,  Sturov, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Review Literature| Revue de littérature
Evolving management strategies for lymphomas during the COVID-19 pandemic	Lang,  N,  Kuruvilla, et al	Leuk Lymphoma	Review Literature| Revue de littérature
A review of the current status of gestational diabetes mellitus in australia—the clinical impact of changing population demographics and diagnostic criteria on prevalence	Laurie,  JG,  McIntyre, et al	International Journal of Environmental Research and Public Health	Review Literature| Revue de littérature
Obesity - A Risk Factor for Psoriasis and COVID-19	Llamas-Velasco,  M,  Ovejero-Merino, et al	Actas Dermosifiliogr	Review Literature| Revue de littérature
Re-Connecting Voices. The (New) Strategic Role of Public Sector Communication After the Covid-19 crisis	Lovari,  A,  Lucia D’Ambrosi, et al	Partecipazione e Conflitto	Review Literature| Revue de littérature
Molecular hydrogen (H(2) ) as a potential treatment for acute and chronic fatigue	Lucas,  K,  Rosch, et al	Arch Pharm (Weinheim)	Review Literature| Revue de littérature
Changes in the pharmaceutical market in terms of COVID-19	Lukianchuk,  V,  Redkina, et al	Systematic Reviews in Pharmacy	Review Literature| Revue de littérature
Health governance: reponses to and effects of COVID-19	MacVane Phipps,  F	International Journal of Health Governance	Review Literature| Revue de littérature
Structure and regulation of coronavirus genomes: state-of-the-art and novel insights from SARS-CoV-2 studies	Manfredonia,  I,  Incarnato, et al	Biochem Soc Trans	Review Literature| Revue de littérature
Biological Significance of Anti-SARS-CoV-2 Antibodies: Lessons Learned From Progressive Multifocal Leukoencephalopathy	Manouchehri,  N,  Steinman, et al	Neurol Neuroimmunol Neuroinflamm	Review Literature| Revue de littérature
Leadership readiness in crisis context: Health preservation through shared knowledge	Maritsa,  E,  Kalemis, et al		Review Literature| Revue de littérature
Classical and alternative receptors for SARS-CoV-2 therapeutic strategy	Masre,  SF,  Jufri, et al	Rev Med Virol	Review Literature| Revue de littérature
Diagnosis/Prognosis of COVID-19 Images: Challenges, Opportunities, and Applications	Mohammadi,  Arash,  Wang, et al	ArXiv	Review Literature| Revue de littérature
Critical Review and Research Needs of Ozone Applications Related to Virus Inactivation: Potential Implications for SARS-CoV-2	Morrison,  C,  Atkinson, et al	Ozone: Science and Engineering	Review Literature| Revue de littérature
Comparison of the immunogenicity & protective efficacy of various SARS-CoV-2 vaccine candidates in non-human primates	Mukhopadhyay,  L,  Yadav, et al	Indian J Med Res	Review Literature| Revue de littérature
CNS implications of COVID-19: A comprehensive review	Nagu,  P,  Parashar, et al	Reviews in the neurosciences	Review Literature| Revue de littérature
COVID-19: What pediatricians learned about peculiarities of the immune response to a new coronavirus infection after year of fighting it	Namazova-Baranova,  L,  Baranov, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Review Literature| Revue de littérature
Vertical Transmission of SARS-CoV-2 from COVID-19 Infected Pregnant Women: A Review on Intrauterine Transmission	Naz,  S,  Rahat, et al	Fetal Pediatr Pathol	Review Literature| Revue de littérature
Antiviral effects of oleandrin	Newman,  RA,  Sastry, et al	Journal of Experimental Pharmacology	Review Literature| Revue de littérature
COVID-19 update: the first 6 months of the pandemic	Novelli,  G,  Biancolella, et al	Hum Genomics	Review Literature| Revue de littérature
Clinical, laboratory-instrumental characteristics, course and therapy of pediatric multisystem inflammatory syndrome associated with covid-19	Novikova,  YY,  Ovsyannikov, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Review Literature| Revue de littérature
Quantifying the Privacy-Utility Trade-offs in COVID-19 Contact Tracing Apps	Ocheja,  Patrick,  Cao, et al	ArXiv	Review Literature| Revue de littérature
Plague and distancing in lope de vega's el ganso de oro	Oechler,  CC	Hipogrifo	Review Literature| Revue de littérature
Extracorporeal Membrane Oxygenation in COVID-19 Treatment: a Systematic Literature Review	Oliveira,  TF,  Rocha, et al	Braz J Cardiovasc Surg	Review Literature| Revue de littérature	SR: Studies were selected from PubMed/MEDLINE and LILACS databases between December 2019 and May 17 2020.  It is evident that more research, covering larger populations, must be carried out in order to clearly elucidate the role of ECMO in the treatment of COVID-19.
Challenges in diagnosing hydroxychloroquine myopathy during the COVID-19 pandemic	Pamphlett,  R,  Wang, et al	Internal Medicine Journal	Review Literature| Revue de littérature
Psychological and Behavioral Impact of Lockdown and Quarantine Measures for COVID-19 Pandemic on Children, Adolescents and Caregivers: A Systematic Review and Meta-Analysis	Panda,  PK,  Gupta, et al	J Trop Pediatr	Review Literature| Revue de littérature	SR-MA: Different electronic databases (MEDLINE, EMBASE, Web of Science, CENTRAL, medRxiv and bioRxiv) were searched. Anxiety, depression, irritability, boredom, inattention and fear of COVID-19 are predominant new-onset psychological problems in children during the COVID-19 pandemic. Children with pre-existing behavioral problems like autism and attention deficit hyperactivity disorder have a high probability of worsening of their behavioral symptoms.
Architectured Therapeutic and Diagnostic Nanoplatforms for Combating SARS-CoV-2: Role of Inorganic, Organic, and Radioactive Materials	Pandey,  A,  Nikam, et al	ACS Biomater Sci Eng	Review Literature| Revue de littérature
Contribution and dilemmas of medical undergraduate students in combating disease outbreaks: COVID 19 and previous outbreaks	Pant,  J,  Pant, et al	Advances in Medical Education and Practice	Review Literature| Revue de littérature
Can You Fish in a Pandemic? An Overview of Recreational Fishing Management Policies in North America During the COVID-19 Crisis	Paradis,  Y,  Bernatchez, et al	Fisheries	Review Literature| Revue de littérature
Prone positioning for ARDS patients-tips for preparation and use during the COVID-19 pandemic	Parhar,  KKS,  Zuege, et al	Can J Anaesth	Review Literature| Revue de littérature
A systematic review of the literature on the role of tracheostomy in COVID-19 patients	Piombino,  P,  Troise, et al	European review for medical and pharmacological sciences	Review Literature| Revue de littérature	SR: analyzed the literature from February 2003 to April 2020.
Considerations for asthma management and viral transmission in the era of COVID-19	Pitlick,  MM,  Joshi, et al	Allergy Asthma Proc	Review Literature| Revue de littérature
Recommendations for the management of urologic patients during the COVID-19 pandemic in Mexico	Quiroz-Compeán,  A,  Oropeza-Aguilar, et al	Revista mexicana de urologia	Review Literature| Revue de littérature
A review on biochemical and immunological biomarkers used for laboratory diagnosis of SARS-CoV-2 (COVID-19)	Ranjbar,  R,  Hosseini, et al	Open Microbiology Journal	Review Literature| Revue de littérature
COVID-19 Pandemic Challenges for Engineering Education	Rassudov,  L,  Korunets, et al		Review Literature| Revue de littérature
Practical recommendations for the management of patients with gastroenteropancreatic and thoracic (carcinoid) neuroendocrine neoplasms in the COVID-19 era	Rodriguez-Freixinos,  V,  Capdevila, et al	Eur J Cancer	Review Literature| Revue de littérature
Venous thromboembolism in COVID-19 patients	Rossi,  FH	Jornal Vascular Brasileiro	Review Literature| Revue de littérature
Comparing the scope and efficacy of covid-19 response strategies in 16 countries: An overview	Rozanova,  L,  Temerev, et al	International Journal of Environmental Research and Public Health	Review Literature| Revue de littérature
Molecular pathways triggered by COVID-19 in different organs: ACE2 receptor-expressing cells under attack? A review	Saba,  L,  Gerosa, et al	European review for medical and pharmacological sciences	Review Literature| Revue de littérature
Blockchain for IoT enabled supply chain management - A systematic review	Sangeetha,  AS,  Shunmugan, et al		Review Literature| Revue de littérature	SR
Statins and clinical outcomes with COVID-19: Meta-analyses of observational studies	Scheen,  AJ	Diabetes Metab	Review Literature| Revue de littérature	MA: Although no significant reductions in either in-hospital mortality or COVID-19 severity were reported among statin users compared with non-users after univariate comparisons, such reductions were observed after adjusting for confounding factors.
SARS-CoV-2 / COVID-19 pandemic – an update	Shanmugam,  R,  Thangavelu, et al	Journal of Experimental Biology and Agricultural Sciences	Review Literature| Revue de littérature
A review of current literature on sudden upsurge of COVID-19	Sharma,  R	Annals of Tropical Medicine and Public Health	Review Literature| Revue de littérature
Unraveling the roles of Vitamin D status and melanin during COVID-19 (Review)	Sidiropoulou,  P,  Docea, et al	International journal of molecular medicine	Review Literature| Revue de littérature
Neurologic manifestations in sars-cov-2 infected patients	Silva,  B,  Jorge, et al	Sinapse	Review Literature| Revue de littérature
Advantages of and Adaptations to Enhanced Recovery Protocols for Perioperative Care During the COVID-19 Pandemic	Stone,  R,  Scheib, et al	J Minim Invasive Gynecol	Review Literature| Revue de littérature
Outdoor disinfectant sprays for the prevention of COVID-19: Are they safe for the environment?	Subpiramaniyam,  S	Science of the Total Environment	Review Literature| Revue de littérature
Teleneurology: Current situation, opportunities and challenges in portugal	Teixeira,  L,  Araújo, et al	Sinapse	Review Literature| Revue de littérature
Age, Multiple Chronic Conditions, and COVID-19: A literature review	Tisminetzky,  M,  Delude, et al	J Gerontol A Biol Sci Med Sci	Review Literature| Revue de littérature
Possible treatment and strategies for COVID-19: review and assessment	Trivedi,  N,  Verma, et al	European review for medical and pharmacological sciences	Review Literature| Revue de littérature
Psychological health and physical activity levels during the covid-19 pandemic: A systematic review	Violant-Holz,  V,  Gallego-Jiménez, et al	International Journal of Environmental Research and Public Health	Review Literature| Revue de littérature	SR:  literature was searched in all databases from the EBSCOhost Research Database—MEDLINE, APA PsycArticles, between others—published between 1 January 2019 and 15 July 2020. This review discusses whether PA is an effective strategy to face the COVID-19 pandemic psychological effects contributing to a further putative increase in the prevalence of psychiatric disorders.
Factors associated with psychological distress during the coronavirus disease 2019 (COVID-19) pandemic on the predominantly general population: A systematic review and meta-analysis	Wang,  Y,  Kala, et al	PLoS One	Review Literature| Revue de littérature	SR-MA: searched PubMed, EMBASE, Scopus, Cochrane Library, PsycINFO, and World Health Organization COVID-19 databases (Dec 2019-15 July 2020). One in three adults in the predominantly general population have COVID-19 related psychological distress. Concerted efforts are urgently needed for interventions in high-risk populations to reduce urban-rural, socioeconomic and gender disparities in COVID-19 related psychological distress.
Digital Pandemic Response Systems: A Strategic Management Framework Against Covid-19	Wirtz,  BW,  Müller, et al	International Journal of Public Administration	Review Literature| Revue de littérature
The systemic review of subgroup analysis on the incidence of acute kidney injury(AKI) in patients with COVID-19	Xu,  Zhenjian,  Tang, et al	Research Square prepub	Review Literature| Revue de littérature	SR: studies in PubMed, Web of Science, medRxiv and EMBASE from 1 Jan 2020 until 1 June 2020. We found that AKI was not rare in hospitalized COVID-19 patients. The incidence of AKI could be associated with age, disease severity and ethnicity. Remdesivir probably not induced AKI in COVID-19 patients.
Spatial and temporal roles of SARS-CoV PL(pro) -A snapshot	Yan,  S,  Wu, et al	Faseb j	Review Literature| Revue de littérature
Emerging infectious diseases and new vaccine technologies	Yang,  HQ,  Liu, et al	Chinese Journal of New Drugs	Review Literature| Revue de littérature
Digestive system manifestations and clinical significance of coronavirus disease 2019: A systematic literature review	Ye,  L,  Yang, et al	Journal of Gastroenterology and Hepatology (Australia)	Review Literature| Revue de littérature	SR: searched PubMed database and Google articles published in both English and Chinese up to June 3, 2020.  Strengthening the recognition on abnormalities in digestive system of patients with COVID-19 is crucial for early identification and timely treatment, especially for those atypical patients. Hygiene protection and keeping the drainpipe free flowing are necessary for everyone.
Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells	Yin,  J,  Kasper, et al	Frontiers in Medicine	Review Literature| Revue de littérature
Complications and Pathophysiology of COVID-19 in the Nervous System	Yu,  H,  Sun, et al	Frontiers in Neurology	Review Literature| Revue de littérature
Prevalence of Anxiety and Depression Among Cancer Patients During the COVID-19 Pandemic: a Systematic Review and Meta-analysis	Yu,  Hongping,  Zhou, et al	Research Square prepub	Review Literature| Revue de littérature	SR-MA: searched the EMBASE, PubMed, WHO COVID-19 database, Cochrane Library, Web of Science, CBM, CNKI, Wanfangdata, CQVIP, and CBM electronic databases for relevant studies published from the first available day to June 30, 2020. Evidence shows that a considerable proportion of patients with malignant tumors suffered from emotional distress during the COVID-19 pandemic. It is important to solve the problem of interruption or delay of treatment and strengthen psychological interventions for patients with malignant tumors during the pandemic.
Cytokine storms caused by novel coronavirus 2019 and treatment for cardiac injury	Zhang,  DM,  Chen, et al	European review for medical and pharmacological sciences	Review Literature| Revue de littérature
Research Status of SARS-CoV-2 on Cardiovascular System Injury in Children	Zhang,  Y,  Wang, et al	Braz J Cardiovasc Surg	Review Literature| Revue de littérature
Technical routes for coronavirus vaccine development	Zhang,  YN,  Ma, et al	Chinese Journal of New Drugs	Review Literature| Revue de littérature
COVID-19 pathogenesis, prognostic factors and treatment strategy: urgent recommendations	Zhou,  B,  Kojima, et al	J Med Virol	Review Literature| Revue de littérature
The potential mechanism of N-acetylcysteine in treating COVID-19	Zhou,  N,  Yang, et al	Curr Pharm Biotechnol	Review Literature| Revue de littérature
Diabetic foot care and management approaches during the global COVID-19 pandemic according to the international working group on the diabetic foot (IWGDF) guidelines	Aalaa,  M,  Amini, et al	Iranian Journal of Endocrinology and Metabolism	Commentary/Editorial| Commentaire/Éditorial
Association of covid-19 pandemic with undergraduate medical students’ perceived stress and coping [response to letter]	Abdulghani,  HM,  Sattar, et al	Psychology Research and Behavior Management	Commentary/Editorial| Commentaire/Éditorial
STUDENTS’ EXPERIENCE REGARDING E-LEARNING DURING THE COVID-19 PANDEMIC AT JOUF UNIVERSITY, SAUDI ARABIA KINGDOM	Abed,  SN,  Ali, et al	PalArch's Journal of Archaeology of Egypt/ Egyptology	Commentary/Editorial| Commentaire/Éditorial
Emerging treatments for COVID-19: Déjà vu all over again?	Ac Lima,  R,  Ferreira, et al	Biomarkers in Medicine	Commentary/Editorial| Commentaire/Éditorial
PMC7328568; "Optimization of Surgical Resident Safety and Education During the COVID-19 Pandemic - Lessons Learned"	Adesoye,  T,  Davis, et al	J Surg Educ	Commentary/Editorial| Commentaire/Éditorial
PMC7665547; Innovations in Diabetes Care for a Better "New Normal" Beyond COVID-19	Agarwal,  S,  Griffith, et al	J Clin Endocrinol Metab	Commentary/Editorial| Commentaire/Éditorial
Drug development post COVID-19 pandemic: toward a better system to meet current and future global health challenges	Aghila Rani,  KG,  Hamad, et al	Expert Opin Drug Discov	Commentary/Editorial| Commentaire/Éditorial
When the Great Equalizer Shuts Down: Schools, Peers, and Parents in Pandemic Times	Agostinelli,  Francesco,  Doepke, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Temporal Strategies and Firms’ Speedy Responses to COVID-19	Ahlstrom,  D,  Wang, et al	Journal of Management Studies	Commentary/Editorial| Commentaire/Éditorial
Step-by-step guide to managing the educational crisis: Lessons learned from COVID-19 pandemic	Ahmed,  S,  Kamel Shehata, et al	Journal of Microscopy and Ultrastructure	Commentary/Editorial| Commentaire/Éditorial
Acute care physiotherapy management of COVID-19 patients in Qatar: Best practice recommendations	Ajimsha,  MS,  Gampawar, et al	International Journal of Therapy and Rehabilitation	Commentary/Editorial| Commentaire/Éditorial
What should we do for the safe transportation of COVID-19 patients?	Akatsuka,  M,  Shimodate, et al	Journal of infection in developing countries	Commentary/Editorial| Commentaire/Éditorial
Exploring parental responses to social and safety needs of school-age children during COVID-19 pandemic in Ogun State, Nigeria	Akinsanya,  OO,  Olaniyi, et al	Journal of Human Behavior in the Social Environment	Commentary/Editorial| Commentaire/Éditorial
Does losing jobs during COVID-19 pandemic affect the knowledge management in businesses?	Al Shehab,  N		Commentary/Editorial| Commentaire/Éditorial
Letter to the editor regarding dental research challenges in the time of COVID-19 and future perspectives	Alaeddini,  M,  Etemad-Moghadam, et al	Cranio	Commentary/Editorial| Commentaire/Éditorial
Importance of the treatment of patients with lip and palate cleft, especially during the COVID-19 pandemic	Alexandre,  LP,  Cançado, et al	Oral Surgery	Commentary/Editorial| Commentaire/Éditorial
The Interactive Effects of Scientific Knowledge and Gender on COVID-19 Social Distancing Compliance	Algara,  C,  Fuller, et al	Social Science Quarterly	Commentary/Editorial| Commentaire/Éditorial
Three cases of suicide during the covid-19 epidemic – the need for action?	Alibegović,  A,  Balažic, et al	Zdravniski Vestnik	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and phosphodiesterase enzyme type 5 inhibitors	Al-Kuraishy,  H,  Al-Gareeb, et al	Journal of Microscopy and Ultrastructure	Commentary/Editorial| Commentaire/Éditorial
Bcg vaccine does not protect against covid-19	Allam,  MF,  Amin, et al	Open Respiratory Medicine Journal	Commentary/Editorial| Commentaire/Éditorial
Vaccination schedules and covid-19 risk	Allam,  MF,  Andraous, et al	Open Microbiology Journal	Commentary/Editorial| Commentaire/Éditorial
Biobanking in the COVID-19 Era and Beyond: Part 2. A Set of Tool Implementation Case Studies	Allocca,  CM,  Snapes, et al	Biopreservation and Biobanking	Commentary/Editorial| Commentaire/Éditorial
Public health strategies for the gradual lifting of the public sector lockdown in Jordan and the United Arab Emirates during the COVID-19 crisis	AlQutob,  R,  Moonesar, et al	JMIR Public Health and Surveillance	Commentary/Editorial| Commentaire/Éditorial
THE PROCEDURES OF EDUCATION ADMINISTRATION AND THE EXPLORATION OF CHALLENGES DURING COVID-19 PANDEMIC IN PALESTINE	Al-Rub,  I	PalArch's Journal of Archaeology of Egypt/ Egyptology	Commentary/Editorial| Commentaire/Éditorial
Integrative medicine considerations for convalescence from mild-to-moderate COVID-19 disease	Alschuler,  L,  Chiasson, et al	Explore (NY)	Commentary/Editorial| Commentaire/Éditorial
Introduction	Anderson,  KB,  Durkin, et al	Marx, Engels, and Marxisms	Commentary/Editorial| Commentaire/Éditorial
Evolution of a Virtual Multidisciplinary Cleft and Craniofacial Team Clinic During the COVID-19 Pandemic: Children's Hospital Colorado Experience	Andrews,  M,  Allen, et al	Cleft Palate Craniofac J	Commentary/Editorial| Commentaire/Éditorial
Iranian journal of basic medical sciences in times of the COVID-19 pandemic	Arabi,  L,  Malaekeh-Nikouei, et al	Iranian Journal of Basic Medical Sciences	Commentary/Editorial| Commentaire/Éditorial
Covid-19: Network effectiveness of intermunicipal self-organized response in Chile	Arias Yurisch,  K,  Retamal Soto, et al	Transylvanian Review of Administrative Sciences	Commentary/Editorial| Commentaire/Éditorial
Covid-19: Tests on students are highly inaccurate, early findings show	Armstrong,  S	Bmj	Commentary/Editorial| Commentaire/Éditorial
The role of artificial intelligence in tackling COVID-19	Arora,  N,  Banerjee, et al	Future Virology	Commentary/Editorial| Commentaire/Éditorial
As três emergências que nossa sociedade enfrenta: saúde, biodiversidade e mudanças climáticas	Artaxo,  P	Estudos Avancados	Commentary/Editorial| Commentaire/Éditorial
The geography of COVID-19 and the structure of local economies: The case of Italy	Ascani,  A,  Faggian, et al	Journal of Regional Science	Commentary/Editorial| Commentaire/Éditorial
Immune Plasma Algorithm: A Novel Meta-heuristic for Optimization Problems	Aslan,  S,  Demirci, et al	IEEE Access	Commentary/Editorial| Commentaire/Éditorial
PMC7756156; Corneal Abrasion from Removing Face Mask during the COVID-19 Pandemic	Au,  SCL,  Ko, et al	Vis J Emerg Med	Commentary/Editorial| Commentaire/Éditorial
The Need for Standardized Metrics to Drive Decision-making During the COVID-19 Pandemic	Austin,  JM,  Kachalia, et al	J Hosp Med	Commentary/Editorial| Commentaire/Éditorial
Vitamin D may protect against multiple organ damage caused by COVID-19	Aygun,  H	Bratislavske lekarske listy	Commentary/Editorial| Commentaire/Éditorial
Pandemic Preparedness and Response to COVID-19 in South Asian Countries	Babu,  GR,  Khetrapal, et al	Int J Infect Dis	Commentary/Editorial| Commentaire/Éditorial
Holding ICDEc 2020 Fully Online: Driving Principles and Key Decisions	Bach Tobji,  MA,  Jallouli, et al		Commentary/Editorial| Commentaire/Éditorial
Physical activity recommendations during the COVID-19 pandemic: a practical approach for different target groups	Baena Morales,  S,  Tauler Riera, et al	Nutr Hosp	Commentary/Editorial| Commentaire/Éditorial
The Increased Exposure to Coronavirus (COVID-19) for Prisoners Justifies Early Release: and the Wider Implications of This for Sentencing – Reducing Most Prison Terms Due to the Harsh Incidental Consequences of Prison	Bagaric,  Mirko,  Isham, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Anticoagulant Protein S in COVID-19: The Low Activity Level Is Probably Secondary	Baicus,  C,  Stoichitoiu, et al	Am J Ther	Commentary/Editorial| Commentaire/Éditorial
Participatory budget and the SARS-CoV-2 pandemic in Poland	Baranowski,  J	Transylvanian Review of Administrative Sciences	Commentary/Editorial| Commentaire/Éditorial
Maintaining quality while adapting to a virtual work environment during the COVID-19 pandemic	Barnett,  E,  Cheung, et al	Journal of Medical Imaging and Radiation Sciences	Commentary/Editorial| Commentaire/Éditorial
Telemedicine, Homecare in the Era of COVID-19 & beyond	Barr,  JR,  D'Auria, et al		Commentary/Editorial| Commentaire/Éditorial
Radium 223 in times of COVID-19	Barreiro,  D,  Cortes, et al	Revista mexicana de urologia	Commentary/Editorial| Commentaire/Éditorial
Riskscapes and the Scaling of Digital Innovation: Trajectory Dynamics of Mobile Payments in Times of Crisis	Barrett,  M		Commentary/Editorial| Commentaire/Éditorial
Covid-19 pandemics: Mitigating an injustice	Barros,  J	Sinapse	Commentary/Editorial| Commentaire/Éditorial
Commentary on Simons et al. (2020): Public health implications of the suggested association between nicotine, smoking and infection with SARS-CoV-2	Bar-Zeev,  Y	Addiction	Commentary/Editorial| Commentaire/Éditorial
Erratum: Preventive behaviors conveyed on YouTube to mitigate transmission of COVID-19: Cross-sectional study (JMIR Public Health and Surveillance (2020) 6:2 (e18807) DOI: 10.2196/18807)	Basch,  CH,  Hillyer, et al	JMIR Public Health and Surveillance	Commentary/Editorial| Commentaire/Éditorial
Reply to: Is the Angioedema Associated with COVID-19 a Real Entity, a Mimic, or Both?	Batarseh,  E,  Kersten, et al	Am J Respir Crit Care Med	Commentary/Editorial| Commentaire/Éditorial
Accountable Care Organizations during Covid-19: Routine care for older adults with multiple chronic conditions	Beckman,  AL,  Mechanic, et al	Healthcare	Commentary/Editorial| Commentaire/Éditorial
Exceptional childhood and COVID-19: Engaging children in a time of civil emergency	Beier,  JM	Childhood	Commentary/Editorial| Commentaire/Éditorial
Xerostomia and Taste Alterations in COVID-19	Belchior Fontenele,  MN,  Pedrosa, et al	Ear Nose Throat J	Commentary/Editorial| Commentaire/Éditorial
The war on infectious diseases: COVID-19 vaccines and the public: Challenges and solutions	Bellanti,  JA,  Settipane, et al	Allergy Asthma Proc	Commentary/Editorial| Commentaire/Éditorial
COVID-19 pandemic reduces general anaesthesia rates for caesarean section	Bhatia,  K,  Columb, et al	Anaesthesia	Commentary/Editorial| Commentaire/Éditorial
The quest continues for perfect COVID-19 vaccine	Bhatia,  R	Indian J Med Res	Commentary/Editorial| Commentaire/Éditorial
Mesurer l'impact de la crise COVID-19 l'expÉrience de la banque de France	Bignon,  V,  Garnier, et al	Revue de l'OFCE	Commentary/Editorial| Commentaire/Éditorial
Together we win: Communities of practice to face the covid crisis in higher education	Bolisani,  E,  Fedeli, et al		Commentary/Editorial| Commentaire/Éditorial
Paid and unpaid work during the Covid-19 pandemic: a study of the gendered division of domestic responsibilities during lockdown	Borah Hazarika,  O,  Das, et al	Journal of Gender Studies	Commentary/Editorial| Commentaire/Éditorial
Editorial 2021 - 50 years of DMFR and hopefully the beginning of the end of the COVID-19 crisis	Bornstein,  MM	Dentomaxillofacial Radiology	Commentary/Editorial| Commentaire/Éditorial
Toward an Intersectional Approach to Health Justice	Borras,  AM	Int J Health Serv	Commentary/Editorial| Commentaire/Éditorial
Changing times – High Court of Australia library during COVID-19	Botherway,  J	Library Management	Commentary/Editorial| Commentaire/Éditorial
Post-COVID-19 severe neutropenia	Bouslama,  B,  Pierret, et al	Pediatr Blood Cancer	Commentary/Editorial| Commentaire/Éditorial
End-of-life care during COVID-19: opportunities and challenges for community nursing	Bowers,  B,  Pollock, et al	Br J Community Nurs	Commentary/Editorial| Commentaire/Éditorial
A Health Intelligence Framework for Pandemic Response: Lessons from the UK Experience of COVID-19	Bowsher,  G,  Bernard, et al	Health Security	Commentary/Editorial| Commentaire/Éditorial
Severe COVID-19: Understanding the role of immunity, endothelium, and coagulation in clinical practice	Brandão,  SCS,  Godoi, et al	Jornal Vascular Brasileiro	Commentary/Editorial| Commentaire/Éditorial
Kawasaki disease and multisystem inflammatory syndrome in children with covid-19 infection	Bregel,  LV,  Kostik, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Commentary/Editorial| Commentaire/Éditorial
A pandemia Covid-19: crise e deterioração do mercado de trabalho no Brasil	Bridi,  MA	Estudos Avancados	Commentary/Editorial| Commentaire/Éditorial
Neglected tropical disease control in a world with COVID-19: an opportunity and a necessity for innovation	Brooker,  SJ,  Ziumbe, et al	Trans R Soc Trop Med Hyg	Commentary/Editorial| Commentaire/Éditorial
COVID-19 by numbers -infections, cases and deaths	Brüssow,  H	Environ Microbiol	Commentary/Editorial| Commentaire/Éditorial
Politics of care in the early years in Australia since the pandemic	Bryant,  L	Global Studies of Childhood	Commentary/Editorial| Commentaire/Éditorial
The ecological consequences of a pandemic: The ecological effects of COVID-19	Buck,  JC,  Weinstein, et al	Biology Letters	Commentary/Editorial| Commentaire/Éditorial
Analysing the impact of the Australian health sector emergency response plan for Novel Coronavirus (COVID-19): A proposed approach	Buck,  T	Evaluation Journal of Australasia	Commentary/Editorial| Commentaire/Éditorial
Turnaround management of airport service providers operating during covid-19 restrictions	Buhusayen,  B,  Seet, et al	Sustainability (Switzerland)	Commentary/Editorial| Commentaire/Éditorial
Reply to "Comprehensive work-up is warranted for patients with severe COVID-19 and muscle weakness including respiratory muscles"	Cabañes-Martínez,  L	Clin Neurophysiol	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and human connection: Collaborative research on loneliness and online worlds from a socially-distanced academy	Cairns,  MR,  Ebinger, et al	Human organization	Commentary/Editorial| Commentaire/Éditorial
Rapid ethnographic assessment of pandemic restrictions in child welfare: Lessons from parent and provider experiences	Callejas,  LM,  Abella, et al	Human organization	Commentary/Editorial| Commentaire/Éditorial
Letter by Cao et al Regarding Article, "History of Stroke Is Independently Associated With In-Hospital Death in Patients With COVID-19"	Cao,  S,  Ge, et al	Stroke	Commentary/Editorial| Commentaire/Éditorial
PMC7378370; Where Does Open Science Lead Us During a Pandemic? A Public Good Argument to Prioritize Rights in the Open Commons	Capps,  B	Camb Q Healthc Ethics	Commentary/Editorial| Commentaire/Éditorial
Leveraging a cloud-based critical care registry for COVID-19 pandemic surveillance and research in Low- And middle-income countries	Care Asia,  CRIT,  Hashmi, et al	JMIR Public Health and Surveillance	Commentary/Editorial| Commentaire/Éditorial
Knowing more about chloroquine/hydroxycloroquine in COVID-19 patients	Cassone,  A,  Iacoviello, et al	Future Microbiology	Commentary/Editorial| Commentaire/Éditorial
Reflection: Airbnb's food-related “online experiences”: a recipe for connection and escape	Cenni,  I,  Vásquez, et al	Food and Foodways	Commentary/Editorial| Commentaire/Éditorial
Sars-cov-2 and multiple sclerosis	Cerqueira,  J	Sinapse	Commentary/Editorial| Commentaire/Éditorial
Is the Angioedema Associated with COVID-19 a Real Entity, a Mimic, or Both?	Chan,  ED,  Majluf-Cruz, et al	Am J Respir Crit Care Med	Commentary/Editorial| Commentaire/Éditorial
Directive Government Policy and Process for the People Amidst COVID-19	Chaturvedi,  Dr Shakti,  Gowda, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
COVID-19 in Malawi: lessons in pandemic preparedness from a tertiary children's hospital	Chaziya,  J,  Freyne, et al	Arch Dis Child	Commentary/Editorial| Commentaire/Éditorial
PMC7228702; Toward a clinically based classification of disease severity for paediatric COVID-19 - Authors' reply	Chen,  D,  Tang, et al	Lancet Infect Dis	Commentary/Editorial| Commentaire/Éditorial
Same pandemic but different studies: An exploration of COVID-19 research at the early stage	Cheng,  X,  Zhou, et al	European review for medical and pharmacological sciences	Commentary/Editorial| Commentaire/Éditorial
Economy or health? A global analysis of the covid-19 pandemic	Chicaíza Becerra,  L,  García Molina, et al	Revista de Economia Institucional	Commentary/Editorial| Commentaire/Éditorial
PMC7378367; Telepsychiatry in the Age of COVID: Some Ethical Considerations	Chin,  HP,  Palchik, et al	Camb Q Healthc Ethics	Commentary/Editorial| Commentaire/Éditorial
“Spotto la quarantena”: Per una analisi dell’italiano scritto degli studenti universitari via social network in tempo di COVID-19	Chiusaroli,  F,  Monti, et al		Commentary/Editorial| Commentaire/Éditorial
Update Alert 4: Masks for Prevention of Respiratory Virus Infections, Including SARS-CoV-2, in Health Care and Community Settings	Chou,  R,  Dana, et al	Ann Intern Med	Commentary/Editorial| Commentaire/Éditorial
Decline of cadaveric dissection in anatomy education during the Covid-19 pandemic: Can it affect future surgeons' competency?	Chytas,  D,  Salmas, et al	Anat Sci Educ	Commentary/Editorial| Commentaire/Éditorial
PMC7604012; COVID-19 and antimalarials. Have we been doing it wrong all along?	Cismaru,  CA,  Cismaru, et al	Eur J Pharmacol	Commentary/Editorial| Commentaire/Éditorial
Architectural Geometry and Graphics Education Some Retrospective Reflections from Italy Across Three Generations	Cocchiarella,  L,  Fazzina, et al		Commentary/Editorial| Commentaire/Éditorial
Beyond Silent Hypoxemia: Does COVID-19 Can Blunt Pain Perception? Comment on "The neuroinvasive potential of SARS CoV2 may play a role in the respiratory failure of COVID 19 patients"	Coen,  M,  Kaiser, et al	J Med Virol	Commentary/Editorial| Commentaire/Éditorial
Science, responsibility and the right to health in the diagnosis of covid-19	Collazo,  CAR,  Rodríguez, et al	Revista Cubana de Educacion Medica Superior	Commentary/Editorial| Commentaire/Éditorial
The covid-19 emergency in european public health: An evaluation of measures in the transition from healthcare services to healthcare profiling	Comite,  U	Transylvanian Review of Administrative Sciences	Commentary/Editorial| Commentaire/Éditorial
Guidelines for management of patients with neuromuscular disorders during covid-19 pandemic	Conceição,  I,  Campos, et al	Sinapse	Commentary/Editorial| Commentaire/Éditorial
The emergency department care for hemodialysis patient during the COVID-19 pandemic	Connealy,  MB,  Lew, et al	American Journal of Emergency Medicine	Commentary/Editorial| Commentaire/Éditorial
Unresolved questions about the treatment of COVID-19 with corticosteroids	Corral-Gudino,  L,  Abadía-Otero, et al	Medicina clinica	Commentary/Editorial| Commentaire/Éditorial
Political institutions and pandemic management: Massive pcr testing	Cortés,  GP	Revista de Economia Institucional	Commentary/Editorial| Commentaire/Éditorial
Educar para um future mais sustentável e inclusivo	Costin,  C	Estudos Avancados	Commentary/Editorial| Commentaire/Éditorial
PMC7587170; Does Copper Prevent Nosocomial Transmission of COVID-19?	Coutureau,  C,  Pascard, et al	J Am Med Dir Assoc	Commentary/Editorial| Commentaire/Éditorial
Managing a library service through a crisis	Cowell,  J	Library Management	Commentary/Editorial| Commentaire/Éditorial
Adding barriers to barriers during the COVID-19 pandemic: a call for interdisciplinary research on communication with migrant patients in the emergency department	Cox,  A,  Iedema, et al	Eur J Emerg Med	Commentary/Editorial| Commentaire/Éditorial
Valuing mobility in a post COVID-19 world	Cresswell,  T	Mobilities	Commentary/Editorial| Commentaire/Éditorial
Neurology training and research in the Covid-19 pandemic: A survey of the Resident and Research Fellow Section of the European Academy of Neurology	Cuffaro,  L,  Carvalho, et al	Eur J Neurol	Commentary/Editorial| Commentaire/Éditorial
Advances of theranostics of 2019-nCoV	Cui,  D	Nano Biomedicine and Engineering	Commentary/Editorial| Commentaire/Éditorial
Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19	Cui,  W,  Yang, et al	Frontiers in Molecular Biosciences	Commentary/Editorial| Commentaire/Éditorial
Masks and Face Coverings for the Lay Public : A Narrative Update	Czypionka,  T,  Greenhalgh, et al	Ann Intern Med	Commentary/Editorial| Commentaire/Éditorial
Racial Disparities in Healthcare: How COVID-19 Ravaged One of the Wealthiest African American Counties in the United States	D,  DR	Soc Work Public Health	Commentary/Editorial| Commentaire/Éditorial
COVID-19: Concern about interrupting social isolation of healthcare workers and professionals. What should be done with the results of the available COVID-19 diagnostic tests?	da Costa,  RB,  de Castro Cardoso Toniasso, et al	European review for medical and pharmacological sciences	Commentary/Editorial| Commentaire/Éditorial
Correction: Stigma in coronavirus disease-19 survivors in Kashmir, India: A cross-sectional exploratory study	Dar,  SA,  Khurshid, et al	PLoS One	Commentary/Editorial| Commentaire/Éditorial
Évaluation au 26 juin 2020 de l'impact Économique de la pandÉmie de la covid-19 et des mesures du confinement et du dÉconfinement en France	Dauvin,  M,  Ducoudré, et al	Revue de l'OFCE	Commentary/Editorial| Commentaire/Éditorial
Impact du choc de demande liÉ Ç la pandÉmie de la COVID-19 en avril 2020 sur l'activitÉ Économique mondiale	Dauvin,  M,  Malliet, et al	Revue de l'OFCE	Commentary/Editorial| Commentaire/Éditorial
After the COVID 19 outbreak in Italy: What have we learnt?	De Filippis,  G,  Cavazzana, et al	Travel Medicine and Infectious Disease	Commentary/Editorial| Commentaire/Éditorial
Between Science and populism: The Brazilian response to COVID-19 from the perspective of the legal determinants of Global Health	de Freitas Lima Ventura,  D,  Martins, et al	Brazilian Journal of International Law	Commentary/Editorial| Commentaire/Éditorial
The Oxford Royal College of General Practitioners Clinical Informatics Digital Hub: Protocol to develop extended COVID-19 surveillance and trial platforms	de Lusignan,  S,  Jones, et al	JMIR Public Health and Surveillance	Commentary/Editorial| Commentaire/Éditorial
How to have lunch in the time of COVID-19	De Vleming,  K,  Kobin, et al	Notices of the American Mathematical Society	Commentary/Editorial| Commentaire/Éditorial
Radiotherapy clinical trial enrollment during the COVID-19 pandemic	De,  B,  Kaiser, et al	Acta Oncol	Commentary/Editorial| Commentaire/Éditorial
Pediatric Emergency Department Visits at US Children's Hospitals During the COVID-19 Pandemic	DeLaroche,  AM,  Rodean, et al	Pediatrics	Commentary/Editorial| Commentaire/Éditorial
Design of a mobile application for the school enrollment process in order to prevent Covid-19	Delgado,  A,  Huamaní, et al	Advances in Science, Technology and Engineering Systems	Commentary/Editorial| Commentaire/Éditorial
To conform or not to conform? Legal norms and human behaviour during the COVID-19 pandemic	Delmastro,  Marco	Research Square prepub	Commentary/Editorial| Commentaire/Éditorial
Catalogo De Datos Covid-19 Transparencia, Innovación Y Compromisso Social (Cataloging COVID-19 Data: Transparency, Innovation and Public Good)	Denny,  Danielle,  Kazim, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Naringerin as candidate drug against SARS-CoV-2: The role for TPC2 genomic variants in COVID-19	Di Maria,  E,  Martini, et al	Pharmacol Res	Commentary/Editorial| Commentaire/Éditorial
Perspectives in Peptide-Based Vaccination Strategies for Syndrome Coronavirus 2 Pandemic	Di Natale,  C,  La Manna, et al	Frontiers in Pharmacology	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and economic recovery in compliance with climate targets	Diesendorf,  M	Global Sustainability	Commentary/Editorial| Commentaire/Éditorial
Connecting During COVID-19: A Protocol of a Volunteer-Based Telehealth Program for Supporting Older Adults' Health	Dikaios,  E,  Sekhon, et al	Frontiers in Psychiatry	Commentary/Editorial| Commentaire/Éditorial
COVID-19 during malaria transmission season in africa and why we should be prepared: An example from senegal	Diongue,  K,  Diallo, et al	Transinformacao	Commentary/Editorial| Commentaire/Éditorial
General practice during COVID-19: an FY2's perspective	Dobler,  E	Br J Gen Pract	Commentary/Editorial| Commentaire/Éditorial
The concept of sustainable development of modern dentistry	Dobrzański,  LA,  Dobrzański, et al	Processes	Commentary/Editorial| Commentaire/Éditorial
COVID-19-induced thrombocytopenia	Dominguez,  NA,  Bastida, et al	Acta Haematologica Polonica	Commentary/Editorial| Commentaire/Éditorial
Covid-19: Challenges for dementia care and research	Dourado,  MCN,  Belfort, et al	Dementia e Neuropsychologia	Commentary/Editorial| Commentaire/Éditorial
Rethinking the teaching and learning of mathematics in light of COVID-19	Dumbaugh,  D,  McCallum, et al	Notices of the American Mathematical Society	Commentary/Editorial| Commentaire/Éditorial
O momento “Bretton Woods” da Covid-19 e a cooperação monetária por bancos centrais	Duran,  CV	Estudos Avancados	Commentary/Editorial| Commentaire/Éditorial
Another silver lining?: Anthropological perspectives on the promise and practice of relaxed restrictions for telemedicine and medication-assisted treatment in the context of COVID-19	Eaves,  ER,  Trotter, et al	Human organization	Commentary/Editorial| Commentaire/Éditorial
Imaging in the aftermath of COVID-19: what to expect	Ebner,  L,  Funke-Chambour, et al	Eur Radiol	Commentary/Editorial| Commentaire/Éditorial
Should We Worry about Government Debt? Thoughts on Australia's COVID-19 Response	Edmond,  C,  Holden, et al	Australian Economic Review	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and Renin Angiotensin Aldosterone System: A Pharmacogenomic View	El Desoky,  ES	Am J Ther	Commentary/Editorial| Commentaire/Éditorial
After COVID-19: The Way We Die from Now On	Elsner,  AM	Camb Q Healthc Ethics	Commentary/Editorial| Commentaire/Éditorial
COVID-19 VACCINE IS HERE!!!	Erhabor,  GE	West African journal of medicine	Commentary/Editorial| Commentaire/Éditorial
Gastrointestinal tract lesion with a new coronavirus infection	Ermolenko,  KD,  Gonchar, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Commentary/Editorial| Commentaire/Éditorial
Opportunities for Improving Population Health in the Post-COVID-19 Era	Essien,  UR,  Corbie-Smith, et al	J Hosp Med	Commentary/Editorial| Commentaire/Éditorial
Entangled roots and otherwise possibilities: An anthropology of disasters COVID-19 research agenda	Faas,  AJ,  Barrios, et al	Human organization	Commentary/Editorial| Commentaire/Éditorial
African Pentecostalism and the 1918 Influenza Pandemic: The Supernatural Amid the Fearful and Implications for the COVID-19 Pandemic	Fagunwa,  Omololu	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Resilience in times of pandemic: Is the public procurement legal framework fit for purpose?*1	Farca,  LA,  Dragoș, et al	Transylvanian Review of Administrative Sciences	Commentary/Editorial| Commentaire/Éditorial
Being on the Frontline? Immigrant Workers in Europe and the Covid-19 Pandemic	Fasani,  Francesco and Mazza,  Jacopo	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and difficult conversations in critical units: A practical guide for nurses	Felix,  AMS,  Pereira, et al	Nurs Crit Care	Commentary/Editorial| Commentaire/Éditorial
Medicamentos e tratamentos para a Covid-19	Ferreira,  LLG,  Andricopulo, et al	Estudos Avancados	Commentary/Editorial| Commentaire/Éditorial
Covid-19 and stroke	Ferro,  JM	Sinapse	Commentary/Editorial| Commentaire/Éditorial
Covid-19, economy and the ‘drop of honey effect’ metaphor – A note on the Portuguese case. Situation and measures	Filipe,  JA	International Journal of Business and Systems Research	Commentary/Editorial| Commentaire/Éditorial
Creating hospitable service systems for refugees during a pandemic: leveraging resources for service inclusion	Finsterwalder,  J,  Kabadayi, et al	Journal of Service Theory and Practice	Commentary/Editorial| Commentaire/Éditorial
Virtual reality and massive multiplayer online role-playing games as possible prophylaxis mathematical model: Focus on COVID-19 spreading	Fiorillo,  L,  Cicciù, et al	Epidemiologic Methods	Commentary/Editorial| Commentaire/Éditorial
Undocumented migrants during the covid-19 pandemic: Socio-economic determinants, clinical features and pharmacological treatment	Fiorini,  G,  Rigamonti, et al	Journal of Public Health Research	Commentary/Editorial| Commentaire/Éditorial
Reflections on the 7th international Jerusalem conference on health policy in the wake of the Covid-19 outbreak	Fischer,  SH	Isr J Health Policy Res	Commentary/Editorial| Commentaire/Éditorial
A reconfiguração das Cadeias Globais de Valor (global value chains) pós-pandemia	Fleury,  A,  Fleury, et al	Estudos Avancados	Commentary/Editorial| Commentaire/Éditorial
Decolonising global health in the time of COVID-19	Fofana,  MO	Glob Public Health	Commentary/Editorial| Commentaire/Éditorial
Response to "The influence of teledermatology on healthcare access and equity"	Franciosi,  EB,  Tan, et al	J Am Acad Dermatol	Commentary/Editorial| Commentaire/Éditorial
Alimentos, Sars-CoV-2 e Covid-19: contato possível, transmissão improvável	Franco,  BDGDM,  Landgraf, et al	Estudos Avancados	Commentary/Editorial| Commentaire/Éditorial
A rapid qualitative appraisal of the impact of COVID-19 on long-term care communities in the United States: Perspectives from area aging staff and advocates	Freidus,  A,  Shenk, et al	Human organization	Commentary/Editorial| Commentaire/Éditorial
What is the urban without physical mobilities? COVID-19-induced immobility in the mobile risk society	Freudendal-Pedersen,  M,  Kesselring, et al	Mobilities	Commentary/Editorial| Commentaire/Éditorial
INSURGENT PLANNING IN PANDEMIC TIMES: The Case of Rio de Janeiro	Friendly,  A	International Journal of Urban and Regional Research	Commentary/Editorial| Commentaire/Éditorial
Families of COVID-19 Patients Say Goodbye on Video: A Structured Approach to Virtual End-of-Life Conversations	Frydman,  JL,  Choi, et al	Journal of palliative medicine	Commentary/Editorial| Commentaire/Éditorial
Embracing the changes imposed by COVID-19 to shape future stoma care service provision	Fulham,  J,  Lowther, et al	British Journal of Nursing	Commentary/Editorial| Commentaire/Éditorial
A digital twin for distant visit of inaccessible contexts	Gabellone,  F		Commentary/Editorial| Commentaire/Éditorial
Impact of COVID-19 on digital platforms and change in E-commerce shopping trends	Galhotra,  B,  Dewan, et al		Commentary/Editorial| Commentaire/Éditorial
Die Rolle der Zahl verfügbarer Intensivbetten bei der Bewältigung der ersten COVID-19-Welle	Gandjour,  A	Gesundheitswesen	Commentary/Editorial| Commentaire/Éditorial
Management and Data Sharing of COVID-19 Pandemic Information	Gao,  F,  Tao, et al	Biopreservation and Biobanking	Commentary/Editorial| Commentaire/Éditorial
Teleneurorehabilitation for Parkinson's Disease: A Panacea for the Times to Come?	Garg,  D,  Dhamija, et al	Annals of Indian Academy of Neurology	Commentary/Editorial| Commentaire/Éditorial
Possível reconfiguração dos modelos educacionais pós-pandemia	Gatti,  BA	Estudos Avancados	Commentary/Editorial| Commentaire/Éditorial
Repigmentation of White Forelock in a Familial Case of Piebaldism Reported via Teledermatology in the COVID-19 Era	Gaudiello,  F,  Ferrillo, et al	Skin Appendage Disorders	Commentary/Editorial| Commentaire/Éditorial
Mental health and the COVID-19 pandemic: Looking back and moving forward	Gavin,  B,  Lyne, et al	Irish Journal of Psychological Medicine	Commentary/Editorial| Commentaire/Éditorial
Reply: Optimal Respiratory Assistance Strategy for Patients with COVID-19	Gershengorn,  HB,  Hu, et al	Ann Am Thorac Soc	Commentary/Editorial| Commentaire/Éditorial
CONSUMPTION OF ANTIBIOTICS AT AN ITALIAN UNIVERSITY HOSPITAL DURING THE EARLY MONTHS OF THE COVID-19 PANDEMIC: WERE ALL ANTIBIOTIC PRESCRIPTIONS APPROPRIATE?	Giacomelli,  A,  Ridolfo, et al	Pharmacol Res	Commentary/Editorial| Commentaire/Éditorial
Equitable Care for Critically Ill Patients from Culturally Diverse Communities in the COVID-19 Pandemic	Gibbon,  LM,  Graybuck, et al	Journal of palliative medicine	Commentary/Editorial| Commentaire/Éditorial
Is aspirin effective in preventing ICU admission in patients with COVID-19 pneumonia? A comment to "Aspirin Use is Associated with Decreased Mechanical Ventilation, ICU Admission, and In-Hospital Mortality in Hospitalized Patients with COVID-19"	Giorgi-Pierfranceschi,  M	Anesth Analg	Commentary/Editorial| Commentaire/Éditorial
Identifying Challenges and Opportunities in Teaching Chemistry Online in India amid COVID-19	Giri,  S,  Dutta, et al	Journal of chemical education	Commentary/Editorial| Commentaire/Éditorial
Vaccination ethics	Giubilini,  A	Br Med Bull	Commentary/Editorial| Commentaire/Éditorial
Navigating the quagmire: Comparison and interpretation of COVID-19 vaccine phase 1/2 clinical trials	Giurgea,  LT,  Memoli, et al	Vaccines	Commentary/Editorial| Commentaire/Éditorial
Delivenng an effective COVID-19 vaccine at record speed	Glover,  G	Manufacturing Chemist	Commentary/Editorial| Commentaire/Éditorial
COVID-19: A Challenge to Physiology of Aging	Golubev,  AG	Frontiers in Physiology	Commentary/Editorial| Commentaire/Éditorial
Planning and uncertainty	González,  JI	Revista de Economia Institucional	Commentary/Editorial| Commentaire/Éditorial
Evidence and Recommendations Regarding Urologic Laparoscopic and Robotic-Assisted Surgery in times of COVID-19	González-Bonilla,  EA,  Rosas-Nava, et al	Revista mexicana de urologia	Commentary/Editorial| Commentaire/Éditorial
Gut feeling is changing in the post-coronavirus world	Gopal,  DP,  Calderón-Larrañaga, et al	Br J Gen Pract	Commentary/Editorial| Commentaire/Éditorial
Topical issues of infectious respiratory pathology in children	Gorelov,  AV,  Nikolaeva, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Commentary/Editorial| Commentaire/Éditorial
Improving Hospital Oxygen Systems for COVID-19 in Low-Resource Settings: Lessons From the Field	Graham,  HR,  Bagayana, et al	Glob Health Sci Pract	Commentary/Editorial| Commentaire/Éditorial
French Pharmacovigilance Public System and COVID-19 Pandemic	Grandvuillemin,  A,  Drici, et al	Drug Saf	Commentary/Editorial| Commentaire/Éditorial
Anthropological engagement with COVID-19	Gray,  D,  Himmelgreen, et al	Human organization	Commentary/Editorial| Commentaire/Éditorial
Diagnostic testing for COVID-19: demonstrated utility of duplicate testing for inpatients in a low incidence setting	Griffin,  DWJ,  Bramwell, et al	Internal Medicine Journal	Commentary/Editorial| Commentaire/Éditorial
The HDvent Emergency Ventilator System	Grimshandl,  David,  Gerken, et al	ArXiv	Commentary/Editorial| Commentaire/Éditorial
Fiscal rule, private debt and rights in Colombia: The recovery after the pandemic	Guerrero,  DAC,  Mora, et al	Revista de Economia Institucional	Commentary/Editorial| Commentaire/Éditorial
Methodological effort in the medical university in times of COVID-19	Guerrero,  MCP,  Olazabal, et al	Revista Cubana de Educacion Medica Superior	Commentary/Editorial| Commentaire/Éditorial
Heritage and the Pandemic: An Early Response to the Restrictions of COVID-19 by the Heritage Sector in England	Guest,  K	Historic Environment: Policy and Practice	Commentary/Editorial| Commentaire/Éditorial
Geoffrey Rose's Strategy of Prevention Applied to COVID-19	Halperin,  W,  Ibrahim, et al	Health Security	Commentary/Editorial| Commentaire/Éditorial
Wearing of medical mask over the high-flow nasal cannula for safer oxygen therapy in the COVID-19 era	Hamada,  S,  Tanabe, et al	Pulmonology	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and acute kidney injury in the intensive care unit	Hardenberg,  JHB,  Stockmann, et al	Nephrologe	Commentary/Editorial| Commentaire/Éditorial
PMC7456272; Covid-19 post-lockdown: A transparent box, used as protective equipment in gastroscopy. A test of feasibility and efficacy	Har-Noy,  O,  Lichtenstein, et al	Dig Liver Dis	Commentary/Editorial| Commentaire/Éditorial
PMC7203162; Why Kill the Cabin Boy?	Harris,  J	Camb Q Healthc Ethics	Commentary/Editorial| Commentaire/Éditorial
Breaking Lockdown during Lockdown: A Neutralization Theory Evaluation of Misbehavior during the Covid 19 Pandemic	Harris,  LC	Deviant Behavior	Commentary/Editorial| Commentaire/Éditorial
Ct scan features and clinical course of covid-19 pneumonia in pregnant women: Can ct predict the prognosis?	Hashemi,  H,  Moradi, et al	Iranian Journal of Radiology	Commentary/Editorial| Commentaire/Éditorial
Optimal Respiratory Assistance Strategy for Patients with COVID-19	Hatipoğlu,  U,  Chatburn, et al	Ann Am Thorac Soc	Commentary/Editorial| Commentaire/Éditorial
PMC7755153; A novel approach to address the novel threat	Hazarika,  M,  Das, et al	Open J Psychiatry Allied Sci	Commentary/Editorial| Commentaire/Éditorial
Measuring Unemployment in Crisis: Effects of COVID-19 on Potential Biases in the CPS	Heffetz,  Ori,  Reeves, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
E-workshop on writing multiple-choice questions: Online experience during the period of COVID-19 crisis	Hefny,  H,  Abbadi, et al	Journal of Microscopy and Ultrastructure	Commentary/Editorial| Commentaire/Éditorial
Effects of cigarette smoking on SARS-CoV-2 receptor ACE2 expression in the respiratory epithelium†	Heijink,  IH,  Hackett, et al	J Pathol	Commentary/Editorial| Commentaire/Éditorial
Solidarity business model for micro-businesses that allows economic reactivation due to COVID-19 in Colombia	Hernández Viveros,  LJ,  Murcia Rodriguez, et al	International Journal of Engineering Research and Technology	Commentary/Editorial| Commentaire/Éditorial
COVID-19-Pandemie-Rationalität statt Regelungschaos tut not	Heudorf,  U	Gesundheitswesen	Commentary/Editorial| Commentaire/Éditorial
Drug information association (DIA) Japan - 17th annual meeting (November 8-10, 2020 - Virtual meeting)	Hihara,  A	Drugs of Today	Commentary/Editorial| Commentaire/Éditorial
Taking care of continence patients during the COVID-19 pandemic	Hillery,  S	British Journal of Nursing	Commentary/Editorial| Commentaire/Éditorial
Interassociation consensus recommendations for pitch-side emergency care and personal protective equipment for elite sport during the COVID-19 pandemic	Hodgson,  L,  Phillips, et al	Br J Sports Med	Commentary/Editorial| Commentaire/Éditorial
PMC7643623; Attitudes and Experiences of Frontline Nursing Home Staff Toward Coronavirus Testing	Hofschulte-Beck,  S,  Hickman, et al	J Am Med Dir Assoc	Commentary/Editorial| Commentaire/Éditorial
COVID-19 induced collapsing glomerulopathy and role of APOL1	Hoilat,  GJ,  Das, et al	Qjm	Commentary/Editorial| Commentaire/Éditorial
Introduction to the special issue: 'COVID-19' under the lens	Hosny,  S	Journal of Microscopy and Ultrastructure	Commentary/Editorial| Commentaire/Éditorial
PMC7361555; Integrating Telemedicine for Medication Treatment for Opioid Use Disorder in Rural Primary Care: Beyond the COVID Pandemic	Hser,  YI,  Mooney, et al	J Rural Health	Commentary/Editorial| Commentaire/Éditorial
Resilience building in service firms during and post COVID-19: COVID-19 疫情之下的服务业的弹性	Huang,  A,  Farboudi Jahromi, et al	Service Industries Journal	Commentary/Editorial| Commentaire/Éditorial
The role of fear in modern societies: Our ancient fear response to new situations is not always helpful in a civilised society	Hunter,  P	EMBO Rep	Commentary/Editorial| Commentaire/Éditorial
Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus	Hussain,  A,  Via, et al	Crit Care	Commentary/Editorial| Commentaire/Éditorial
Malaria and COVID-19: unmasking their ties	Hussein,  MIH,  Albashir, et al	Malar J	Commentary/Editorial| Commentaire/Éditorial
The impact of COVID-19 on dermatology outpatient services in England in 2020	Ibrahim,  LS,  Venables, et al	Clin Exp Dermatol	Commentary/Editorial| Commentaire/Éditorial
Influence of nanotechnology in polymeric textiles, applications, and fight against COVID-19	Idumah,  CI	Journal of the Textile Institute	Commentary/Editorial| Commentaire/Éditorial
Vaccine prophylaxis during the covid-19 pandemic. Specific prevention of coronavirus infection	Iosefovich,  OV	Pediatriya - Zhurnal im G.N.Speranskogo	Commentary/Editorial| Commentaire/Éditorial
Lockdown captivity: the wish to break out and travel	Irimiás,  AR,  Mitev, et al	Current Issues in Tourism	Commentary/Editorial| Commentaire/Éditorial
Tackling the COVID-19 pandemic: The Bangladesh perspective	Islam,  MT,  Talukder, et al	Journal of Public Health Research	Commentary/Editorial| Commentaire/Éditorial
In Reply: Dismantling the Apocalypse Narrative: The Myth of the COVID-19 Stroke	Jabbour,  P,  Sweid, et al	Neurosurgery	Commentary/Editorial| Commentaire/Éditorial
Factors associated with psychological outcomes among frontline healthcare providers of India during COVID-19 pandemic	Jacob,  J,  Vr, et al	Asian J Psychiatr	Commentary/Editorial| Commentaire/Éditorial
Utilizing Take-Home Examinations in Upper-Level Analytical Lecture Courses in the Wake of the COVID-19 Pandemic	Jacobs,  AD	Journal of chemical education	Commentary/Editorial| Commentaire/Éditorial
EMJ COVID-19 monthly top five	Jafar,  AJN,  Darbyshire, et al	Emerg Med J	Commentary/Editorial| Commentaire/Éditorial
Comment on "digital mental health and COVID-19: Using technology today to accelerate the curve on access and quality tomorrow"	Jain,  N,  Jayaram, et al	JMIR Mental Health	Commentary/Editorial| Commentaire/Éditorial
Ventilation perfusion lung SPECT/CT in pregnancy during COVID-19	Jewell,  KE,  Lee, et al	Internal Medicine Journal	Commentary/Editorial| Commentaire/Éditorial
Conclusions of the IX Conference of the Aviles Group on Sports Medicine	Jiménez-López,  L	Revista Andaluza de Medicina del Deporte	Commentary/Editorial| Commentaire/Éditorial
Posttraumatic Stress Disorder Exacerbation as a Result of Public Masking in Times of COVID-19	Jolly,  TS,  Pandian, et al	Prim Care Companion CNS Disord	Commentary/Editorial| Commentaire/Éditorial
Re-Addressing the Needs of Cancer Survivors during COVID-19: A Path Forward	Jones,  JM,  Saeed, et al	J Natl Cancer Inst	Commentary/Editorial| Commentaire/Éditorial
Responding to the "unknown assailant": A qualitative exploration with Australian health and aged care chaplains on the impact of COVID-19	Jones,  KF,  Washington, et al	J Health Care Chaplain	Commentary/Editorial| Commentaire/Éditorial
Health promotion for workers focusing on physical activity and sedentary behavior: Epidemiological studies in occupational health at the Physical Fitness Research Institute	Kai,  Y,  Kitano, et al	Japanese Journal of Physical Fitness and Sports Medicine	Commentary/Editorial| Commentaire/Éditorial
Caring for Noncritically Ill Coronavirus Patients	Kaiksow,  FA,  Jones, et al	J Hosp Med	Commentary/Editorial| Commentaire/Éditorial
Mining a GWAS of Severe Covid-19	Karim,  M,  Dunham, et al	N Engl J Med	Commentary/Editorial| Commentaire/Éditorial
Data management, semantics and personal health apps for staying safe in COVID-19	Katehakis,  DG,  Kouroubali, et al		Commentary/Editorial| Commentaire/Éditorial
Mining a GWAS of Severe Covid-19	Katz,  DH,  Wilson, et al	N Engl J Med	Commentary/Editorial| Commentaire/Éditorial
Arterio-venous fistula surgery can be safely delivered in the COVID-19 pandemic era	Khalid,  U,  Ilham, et al	J Vasc Access	Commentary/Editorial| Commentaire/Éditorial
Heart failure and COVID-19: synergism of two inflammatory conditions?	Khan,  E	Br J Community Nurs	Commentary/Editorial| Commentaire/Éditorial
Simple Modifications of Therapeutic Plasma Exchange Treatments during the SARS-CoV-2 Pandemic	Khouri,  J,  Royer, et al	Transfusion	Commentary/Editorial| Commentaire/Éditorial
The short-term impact of the COVID-19 outbreak on suicides in Korea	Kim,  AM	Psychiatry research	Commentary/Editorial| Commentaire/Éditorial
Repurposing covid-19 drive-through testing centers for mass vaccination	Kim,  E	Journal of Multidisciplinary Healthcare	Commentary/Editorial| Commentaire/Éditorial
Professional Identity Formation During the COVID-19 Pandemic	Kinnear,  B,  Zhou, et al	J Hosp Med	Commentary/Editorial| Commentaire/Éditorial
PMC7685133; New Answers to Old Questions: Waitlist Versus Transplant Outcomes in the Coronavirus Disease 2019 Era	Klassen,  D	Kidney Int Rep	Commentary/Editorial| Commentaire/Éditorial
Government insurance for business interruption losses from pandemics: An evaluation of its feasibility and possible frameworks	Klein,  RW,  Weston, et al	Risk Management and Insurance Review	Commentary/Editorial| Commentaire/Éditorial
Äa&nderung der GDM-Diagnostik für die Dauer der SARS-CoV-2-Pandemie - Wie viele Schwangere fallen durchs Netz?	Kleinwechter,  H	Diabetologie und Stoffwechsel	Commentary/Editorial| Commentaire/Éditorial
Self-reported skin sensation by people who have experienced containment during covid-19 pandemic	Kluger,  N,  Floc'h, et al	Clinical, Cosmetic and Investigational Dermatology	Commentary/Editorial| Commentaire/Éditorial
Language Barriers, Equity, and COVID-19: The Impact of a Novel Spanish Language Care Group	Knuesel,  S,  Chuang, et al	J Hosp Med	Commentary/Editorial| Commentaire/Éditorial
Impacts of Covid-19 on Household Welfare in Tunisia	Kokas,  Deeksha,  Lopez-Acevedo, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
The COVID-19 Pandemic Shows How Vital the Broadband Internet Infrastructure Is	Köksal,  Emin	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
The impact of COVID-19 on the organisation of surgical activity	Komadina,  R,  Crnjac, et al	Zdravniski Vestnik	Commentary/Editorial| Commentaire/Éditorial
Engineering Asset Management at Times of Major, Large-Scale Instabilities and Disruptions	Komljenovic,  D		Commentary/Editorial| Commentaire/Éditorial
2020 Food and Drug Law Institute (FDLI) Annual Conference (October 6-8, 2020 - Virtual Meeting)	Komlos,  D	Drugs of Today	Commentary/Editorial| Commentaire/Éditorial
The state of the Russian payment market: Digitalization and the impact of COVID-19	Korobeynikova,  O,  Burkaltseva, et al		Commentary/Editorial| Commentaire/Éditorial
Bioethical considerations for cancer patient care during the COVID-19 pandemic	Kourie,  HR,  Eid, et al	Future Oncology	Commentary/Editorial| Commentaire/Éditorial
Viral encounters: Xenophobia, solidarity, and place-based lessons from Chinese Migrants in Italy	Krause,  EL,  Bressan, et al	Human organization	Commentary/Editorial| Commentaire/Éditorial
The "new normal" in academia: What covid-19 reveals about (legal) publishing and online scholarly communication	Krisztián,  A,  Ceran, et al	European Journal of Legal Studies	Commentary/Editorial| Commentaire/Éditorial
Challenges of Cancer Immunotherapy during the COVID-19 Pandemic	Kuderer,  NM,  Lyman, et al	Cancer Invest	Commentary/Editorial| Commentaire/Éditorial
Global Regulators Set Standards for Safe Vaccines	Kuehn,  BM	JAMA - Journal of the American Medical Association	Commentary/Editorial| Commentaire/Éditorial
Bilateral premacular sub-hyaloid hemorrhage-unmasking COVID-19 induced pancytopenia	Kumar,  A,  Kumar, et al	J Med Virol	Commentary/Editorial| Commentaire/Éditorial
COVID 19 LOCKDOWN AND MEDIA: A STUDY ON SELECTED EDITORIALS	Kumar,  P,  Krishnaswami, et al	PalArch's Journal of Archaeology of Egypt/ Egyptology	Commentary/Editorial| Commentaire/Éditorial
Response by Kummer et al to Letter Regarding Article, "History of Stroke Is Independently Associated With In-Hospital Death in Patients With COVID-19"	Kummer,  BR,  Klang, et al	Stroke	Commentary/Editorial| Commentaire/Éditorial
The Future of Nanotechnology and Quantum Dots for the Treatment of COVID-19	Kusrini,  E,  Asvial, et al	International Journal of Technology	Commentary/Editorial| Commentaire/Éditorial
A mysterious surge of aspergillosis among non-SARS-CoV-2 patients during COVID-19 pandemic	Lai,  CC,  Chen, et al	Journal of Microbiology, Immunology and Infection	Commentary/Editorial| Commentaire/Éditorial
Clinical, laboratory and imaging predictors for critical illness and mortality in patients with COVID-19: protocol for a systematic review and meta-analysis	Lai,  X,  Liu, et al	BMJ Open	Commentary/Editorial| Commentaire/Éditorial
Pricing and liquidity of fixed income ETFs in the COVID-19 Virus crisis of 2020	Laipply,  S,  Madhavan, et al	Journal of Index Investing	Commentary/Editorial| Commentaire/Éditorial
SARS-CoV-2: a protocol for disinfection of toothbrushes	Lamarca,  JH,  de Carvalho, et al	J Infect Dis	Commentary/Editorial| Commentaire/Éditorial
The impact of the COVID 19 pandemic on emergency department attendance: What seems to be keeping the patients away?	Lateef,  F	Journal of Emergencies, Trauma and Shock	Commentary/Editorial| Commentaire/Éditorial
Infection control measures, in situ simulation, and failure modes and effect analysis to fine-tune change management during COVID-19	Lateef,  F,  Stawicki, et al	Journal of Emergencies, Trauma and Shock	Commentary/Editorial| Commentaire/Éditorial
The Devastating Cost of Racial and Ethnic Health Inequity in the COVID-19 Pandemic	Lee,  IJ,  Ahmed, et al	Journal of the National Medical Association	Commentary/Editorial| Commentaire/Éditorial
Populism, environmental law, and the post-pandemic order	Lehmen,  A	Brazilian Journal of International Law	Commentary/Editorial| Commentaire/Éditorial
COVID-19 coagulopathy: is it disseminated intravascular coagulation?	Levi,  M,  Iba, et al	Intern Emerg Med	Commentary/Editorial| Commentaire/Éditorial
Editorial: Growth and development in a time of coronavirus	Levitsky,  LL,  Koren, et al	Curr Opin Endocrinol Diabetes Obes	Commentary/Editorial| Commentaire/Éditorial
Bioethics met its COVID-19 Waterloo: The doctor knows best again	Lewis,  J,  Schuklenk, et al	Bioethics	Commentary/Editorial| Commentaire/Éditorial
Aotearoa New Zealand: keeping the virus at bay	Lilley,  S	Library Management	Commentary/Editorial| Commentaire/Éditorial
Interpretation of the Basic and Effective Reproduction Number	Lim,  JS,  Cho, et al	Journal of preventive medicine and public health = Yebang Uihakhoe chi	Commentary/Editorial| Commentaire/Éditorial
The lawsuit against the United States for causing COVID-19	Limsira,  P	Journal of East Asia and International Law	Commentary/Editorial| Commentaire/Éditorial
Pathological (Im)mobilities: managing risk in a time of pandemics	Lin,  W,  Yeoh, et al	Mobilities	Commentary/Editorial| Commentaire/Éditorial
The continuing impact of COVID-19 on dermatology practice: Office workflow, economics, and future implications	Litchman,  GH,  Marson, et al	Journal of the American Academy of Dermatology	Commentary/Editorial| Commentaire/Éditorial
Risk of SARS-CoV-2 Transmission in Health Care Personnel Working in a Pediatric COVID-19 Unit	Lo Vecchio,  A,  Pierri, et al	Hosp Pediatr	Commentary/Editorial| Commentaire/Éditorial
Escalation of commitment amongst collective decision makers: Learnings for company boards from New Zealand's Covid-19 panic	Lockhart,  J		Commentary/Editorial| Commentaire/Éditorial
A Tale of COVID-19: Beyond Physical Ailment	Lohiya,  N,  Lohiya, et al	Indian Pediatr	Commentary/Editorial| Commentaire/Éditorial
Safety, diagnostic, and therapeutic value of flexible bronchoscopy in critically ill COVID-19 patients	Loor,  K,  Álvarez, et al	Can J Anaesth	Commentary/Editorial| Commentaire/Éditorial
The COVID-19 Pandemic in Italy and the World: To Be or Not to Be? That Is the Real Problem	Lorettu,  L,  Dessanti, et al	Health Security	Commentary/Editorial| Commentaire/Éditorial
When informal work and poor work conditions backfire and fuel the COVID-19 pandemic: Why we should listen to the lessons from Latin America	Lotta,  G,  Kuhlmann, et al	Int J Health Plann Manage	Commentary/Editorial| Commentaire/Éditorial
Stress-coping strategies by medical students during the covid-19 pandemic [letter]	Low,  JM,  Zakariya, et al	Psychology Research and Behavior Management	Commentary/Editorial| Commentaire/Éditorial
PMC7647901; In-House Production of Dialysis Solutions to Overcome Challenges During the Coronavirus Disease 2019 Pandemic	Lumlertgul,  N,  Tunstell, et al	Kidney Int Rep	Commentary/Editorial| Commentaire/Éditorial
Rethinking developed nations’ health systems through a social sustainability perspective in the light of the COVID-19 pandemic. A viewpoint	Macassa,  G,  Tomaselli, et al	Journal of Public Health Research	Commentary/Editorial| Commentaire/Éditorial
Pharmacological treatment of covid-19 and treatment of migraine crisis	Machado,  S	Sinapse	Commentary/Editorial| Commentaire/Éditorial
Pharmacological treatment of covid-19 and cluster headache	Machado,  S	Sinapse	Commentary/Editorial| Commentaire/Éditorial
Covid-19: What have we learnt about the new variant in the UK?	Mahase,  E	Bmj	Commentary/Editorial| Commentaire/Éditorial
Covid-19: UK regulator approves lateral flow test for home use despite accuracy concerns	Mahase,  E	Bmj	Commentary/Editorial| Commentaire/Éditorial
Evaluating understandings of state and federal pandemic policies: The situation of refugees from the Congo Wars in Tampa, Florida	Mahoney,  D,  Obure, et al	Human organization	Commentary/Editorial| Commentaire/Éditorial
Insights into the impactful usage of virtual reality for end users	Malvika,  K,  Malathi, et al		Commentary/Editorial| Commentaire/Éditorial
NHS workplace health and wellbeing during COVID-19	Manning,  V,  Pattani, et al	Perspect Public Health	Commentary/Editorial| Commentaire/Éditorial
Preventing the digital scars of COVID	Marabelli,  Marco,  Vaast, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
“I Told You the Invisible Can Kill You”: Engaging Anthropology as a Response in the COVID-19 Outbreak in Italy	Marabello,  S,  Parisi, et al	Human organization	Commentary/Editorial| Commentaire/Éditorial
Strategies for COVID-19 Pandemic Recovery: Application of Engineering Asset Management Principles	Márquez,  AC		Commentary/Editorial| Commentaire/Éditorial
The impact of COVID-19 on adhesion science	Martín-Martínez,  JM	Journal of Adhesion Science and Technology	Commentary/Editorial| Commentaire/Éditorial
What Can We Learn About Psychological Aging By Studying Covid-19?	Martire,  LM,  Isaacowitz, et al	J Gerontol B Psychol Sci Soc Sci	Commentary/Editorial| Commentaire/Éditorial
Academic libraries in COVID-19: a renewed mission for digital literacy	Martzoukou,  K	Library Management	Commentary/Editorial| Commentaire/Éditorial
A Potential Bioelectromagnetic Method to Slow Down the Progression and Prevent the Development of Ultimate Pulmonary Fibrosis by COVID-19	Masaud,  SM,  Szasz, et al	Frontiers in Immunology	Commentary/Editorial| Commentaire/Éditorial
Erratum: A snapshot of SARS-CoV-2 genome availability up to April 2020 and its implications: Data analysis (JMIR Public Health and Surveillance (2020) 6:2 (e19170) DOI: 10.2196/19170)	Mavian,  C,  Marini, et al	JMIR Public Health and Surveillance	Commentary/Editorial| Commentaire/Éditorial
Онлайн пространство в условиях пандемии: коммуникационный и антропологический подход (Online Environment in a Pandemic: Communication and Anthropological Approach)	Maximova,  LN,  F	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Risk Assessment and Guidelines on the Risk Management of COVID-19 in Zimbabwe	Mazikana,  Anthony Tapiwa	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Exploring forgotten knowledge to enhance effective knowledge deliver in aid organisations	Mazuze,  J,  Turner, et al		Commentary/Editorial| Commentaire/Éditorial
From COVID-19 to ALS: Looking Beyond Just Black and White	McClean,  JC,  Russell, et al	Neurology	Commentary/Editorial| Commentaire/Éditorial
Urban governance innovation and COVID-19	McGuirk,  P,  Dowling, et al	Geographical Research	Commentary/Editorial| Commentaire/Éditorial
Rethinking refuge in the time of COVID-19	Meer,  N,  Hill, et al	Ethnic and Racial Studies	Commentary/Editorial| Commentaire/Éditorial
Finding Horcrux of psychiatric symptoms in COVID-19: Deficiencies of amino acids and vitamin D	Mehta,  A,  Soni, et al	Asian J Psychiatr	Commentary/Editorial| Commentaire/Éditorial
COVID-19 überstanden und dennoch krank	Meinrenken,  S	Pneumologie	Commentary/Editorial| Commentaire/Éditorial
COVID-19: Kommen wir aus dem Lockdown wieder heraus?	Meinrenken,  S	Pneumologie	Commentary/Editorial| Commentaire/Éditorial
Degrees of freedom: Limitations of infrared thermography for screening for Covid-19 and other infections	Mekjavic,  IB,  Tipton, et al	Exp Physiol	Commentary/Editorial| Commentaire/Éditorial
Plasma exchange in the treatment of complex COVID-19 related critical illness: controversies and perspectives	Memish,  ZA,  Faqihi, et al	Int J Antimicrob Agents	Commentary/Editorial| Commentaire/Éditorial
Tackling inequitable distribution of the COVID-19 vaccine	Mendes,  A	Br J Community Nurs	Commentary/Editorial| Commentaire/Éditorial
Performing Ultrasound-Guided Percutaneous Tracheostomy in COVID-19 Patients	Menegozzo,  CAM,  Rocha, et al	Journal of the American College of Surgeons	Commentary/Editorial| Commentaire/Éditorial
Reorganization of the working process in ljubljana maternity hospital during SARS-CoV-2 pandemic	Mesarič,  VA,  Pogačnik, et al	Zdravniski Vestnik	Commentary/Editorial| Commentaire/Éditorial
Clinical and virological follow-up of a cohort of 76 COVID-19 older hospitalized adults	Meyer,  M,  Calabrese, et al	J Am Geriatr Soc	Commentary/Editorial| Commentaire/Éditorial
Is EAM a Corporate Level Strategy?	Mills,  DE,  Pudney, et al		Commentary/Editorial| Commentaire/Éditorial
Expert consensus on clinical prevention and treatment of COVID-19	Min,  Z,  En-Qiang, et al	Medical Journal of Chinese People's Liberation Army	Commentary/Editorial| Commentaire/Éditorial
Post-pandemic city: Historical context for new urban design	Mir,  V	Transylvanian Review of Administrative Sciences	Commentary/Editorial| Commentaire/Éditorial
Debt and Deficits—A Modern Monetary Theory Perspective	Mitchell,  WF	Australian Economic Review	Commentary/Editorial| Commentaire/Éditorial
Remote Controlled Laboratory Experiments for Engineering Education in the Post-COVID-19 Era: Concept and Example	Mohammed,  AK,  El Zoghby, et al		Commentary/Editorial| Commentaire/Éditorial
What COVID-19 may teach us about interdisciplinarity	Mol,  A,  Hardon, et al	BMJ Global Health	Commentary/Editorial| Commentaire/Éditorial
Safety pathway design for patients not affected by covid-19 during the SARS-CoV-2 pandemic in an Italian university hospital	Montella,  E,  Caputi, et al	Risk Management and Healthcare Policy	Commentary/Editorial| Commentaire/Éditorial
2020: The Year of the COVID-19 Pandemic	Morley,  JE	Journal of Nutrition, Health and Aging	Commentary/Editorial| Commentaire/Éditorial
Editorial: 2020: The Year of The COVID-19 Pandemic	Morley,  JE	J Nutr Health Aging	Commentary/Editorial| Commentaire/Éditorial
Nanotechnology shows promise for next-generation vaccines in the fight against COVID-19	Mufamadi,  MS	MRS Bulletin	Commentary/Editorial| Commentaire/Éditorial
Safety of secukinumab treatment in COVID-19 affected psoriatic patients	Mugheddu,  C,  Sanna, et al	Dermatol Ther	Commentary/Editorial| Commentaire/Éditorial
Digital innovation in medicine: the COVID-19 pandemic as an accelerator of “digital health”	Mumm,  JN,  Rodler, et al	Journal fur Urologie und Urogynakologie	Commentary/Editorial| Commentaire/Éditorial
Inequality in the Time of Corona Virus	Munir,  KA	Journal of Management Studies	Commentary/Editorial| Commentaire/Éditorial
Rethinking the public space in pandemic times: Hannah arendt, 60 years after the publication of the human condition	Nagamine,  R,  Vitale, et al	Caderno CRH	Commentary/Editorial| Commentaire/Éditorial
CARDS vs ARDS – implications for respiratory support	Naidoo,  KD	Southern African Journal of Anaesthesia and Analgesia	Commentary/Editorial| Commentaire/Éditorial
Correction to: Genome evolution of SARS-CoV-2 and its virological characteristics (Inflammation and Regeneration, (2020), 40, 1, (17), 10.1186/s41232-020-00126-7)	Nakagawa,  S,  Miyazawa, et al	Inflammation and Regeneration	Commentary/Editorial| Commentaire/Éditorial
Corrigendum to: Risk factors for positive and negative COVID-19 tests: a cautious and in-depth analysis of UK Biobank data	Nalini,  M,  Khoshnia, et al	Int J Epidemiol	Commentary/Editorial| Commentaire/Éditorial
Beating the Covid-19 blues with dance and songs: women’s group work in the times of a pandemic	Nancy	Social Work with Groups	Commentary/Editorial| Commentaire/Éditorial
Comment on sex tourism in the era of COVID-19	Naumov,  N	J Travel Med	Commentary/Editorial| Commentaire/Éditorial
Domestic violence challenge and covid-19 pandemic	Nojomi,  M,  Babaee, et al	Journal of Public Health Research	Commentary/Editorial| Commentaire/Éditorial
PMC7262024; Navigating Nonessential Research Trials During COVID-19: The Push We Needed for Using Digital Technology to Increase Access for Rural Participants?	Noonan,  D,  Simmons, et al	J Rural Health	Commentary/Editorial| Commentaire/Éditorial
Acceptability of a community health worker intervention to improve the oral health of older Chinese Americans: A pilot study	Northridge,  ME,  Wu, et al	Gerodontology	Commentary/Editorial| Commentaire/Éditorial
Simulations and virtual learning supporting clinical education during the covid 19 pandemic [letter]	Novintan,  S,  Mann, et al	Advances in Medical Education and Practice	Commentary/Editorial| Commentaire/Éditorial
Theoretical dialogue and interdisciplinary relevance: Thirty years of Theory & Psychology	O’Doherty,  KC	Theory and Psychology	Commentary/Editorial| Commentaire/Éditorial
Covid-19: Emerging Considerations for Body Sourcing and Handling.A Perspective View from Nigeria	Okafor,  IA,  Chia, et al	Anat Sci Educ	Commentary/Editorial| Commentaire/Éditorial
Essential work, precarious labour: The need for safer and equitable harm reduction work in the era of COVID-19	Olding,  M,  Barker, et al	International Journal of Drug Policy	Commentary/Editorial| Commentaire/Éditorial
Work stands modeling in additive manufacturing	Olender,  M	International Journal of Modern Manufacturing Technologies	Commentary/Editorial| Commentaire/Éditorial
Immunometabolism at the cornerstone of inflammaging, immunosenescence, and autoimmunity in COVID-19	Omarjee,  L,  Perrot, et al	Aging (Albany NY)	Commentary/Editorial| Commentaire/Éditorial
Military trauma and orthopaedics experience of the UK COVID-19 pandemic: a lesson in versatility and how it can influence our deployed role	Packer,  T,  McMenemy, et al	BMJ Mil Health	Commentary/Editorial| Commentaire/Éditorial
Social Inequity and the COVID-19 Pandemic	Pacquiao,  DF	J Transcult Nurs	Commentary/Editorial| Commentaire/Éditorial
The pharmacological potential of plant compounds and preparations in COVID-19: A PTR virtual issue	Pagano,  E	Phytother Res	Commentary/Editorial| Commentaire/Éditorial
Calcitonin gene-related peptide (Cgrp) and sars-cov-2	Palavra,  F	Sinapse	Commentary/Editorial| Commentaire/Éditorial
New-Onset Diabetes in COVID-19: Time to Frame Its Fearful Symmetry	Papachristou,  S,  Stamatiou, et al	Diabetes Ther	Commentary/Editorial| Commentaire/Éditorial
Risk Assessment of Autopsy-Acquired Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2; Coronavirus Disease 2019)	Parkash,  V,  Smith, et al	Arch Pathol Lab Med	Commentary/Editorial| Commentaire/Éditorial
Physical Distancing for Care Delivery in Healthcare Settings: Considerations and Consequences	Parmasad,  V,  Keating, et al	Am J Infect Control	Commentary/Editorial| Commentaire/Éditorial
PMC7262323; Ethical and Legal Challenges During the COVID-19 Pandemic: Are We Thinking About Rural Hospitals?	Patel,  L,  Elliott, et al	J Rural Health	Commentary/Editorial| Commentaire/Éditorial
The vital potential of ayurveda in COVID-19 pandemic	Pawar,  S,  Joshi, et al	International Journal of Current Research and Review	Commentary/Editorial| Commentaire/Éditorial
The COVID-19 Pandemic and the Relevance of Ayurveda's Whole Systems Approach to Health and Disease Management	Payyappallimana,  U,  Patwardhan, et al	Journal of Alternative and Complementary Medicine	Commentary/Editorial| Commentaire/Éditorial
The disproportionate impact of COVID-19 on women relative to men: A conservation of resources perspective	Peck,  JA	Gender, Work and Organization	Commentary/Editorial| Commentaire/Éditorial
A centralised novel coronavirus telephone helpline: A tool for managing and tracking the nation’s response to the COVID-19 epidemic in Slovenia	Pelicon,  K,  Krajnc, et al	Zdravniski Vestnik	Commentary/Editorial| Commentaire/Éditorial
The challenges of a children’s hospital during the COVID-19 pandemic: The pediatric surgeon’s point of view	Pelizzo,  G,  Costanzo, et al	Pediatric Reports	Commentary/Editorial| Commentaire/Éditorial
Prevention of headache and neuralgia during the covid-19 pandemic	Pereira,  L	Sinapse	Commentary/Editorial| Commentaire/Éditorial
Promoting Access of Osteopathic Medical Students to Surgical Residency Training Programs	Petree,  BS,  Heard, et al	Am Surg	Commentary/Editorial| Commentaire/Éditorial
Coronavirus: the science behind infection control and human exposure	Phillis,  A	Br J Community Nurs	Commentary/Editorial| Commentaire/Éditorial
Pediatric and adult patients diagnosed with celiac disease are not at higher risk of contracting SARS-CoV-2 (COVID-19)	Pinto-Sanchez,  M,  Verdu, et al	Clin Gastroenterol Hepatol	Commentary/Editorial| Commentaire/Éditorial
Unconventional seats for students returning to school during the worldwide COVID-19 pandemic: Has Italy taken the right direction?	Polastri,  M,  Swann, et al	International Journal of Therapy and Rehabilitation	Commentary/Editorial| Commentaire/Éditorial
Surveillance of Psoriatic Patients on Biologic Treatment During The COVID-19 Pandemic: A Single-Center Experience	Polat Ekinci,  A,  Pehlivan, et al	Dermatol Ther	Commentary/Editorial| Commentaire/Éditorial
Rapid Systems Response to COVID-19: Standards Disseminated as Digital Health Packages	Poppe,  O,  Saugene, et al		Commentary/Editorial| Commentaire/Éditorial
“Stay at home” for addressing COVID-19 protocol: learning from the traditional Balinese house	Putra,  IDGAD	Archnet-IJAR	Commentary/Editorial| Commentaire/Éditorial
Why weren’t we ready for the coronavirus?	Quammen,  D	Revista de Economia Institucional	Commentary/Editorial| Commentaire/Éditorial
Two passions, one goal, and a pandemic: The future of medical education in South Africa	Quan,  C	Southern African Journal of Anaesthesia and Analgesia	Commentary/Editorial| Commentaire/Éditorial
Is Vietnam ready to welcome tourists back? Assessing COVID-19’s economic impact and the Vietnamese tourism industry’s response to the pandemic	Quang,  TD,  Tran, et al	Current Issues in Tourism	Commentary/Editorial| Commentaire/Éditorial
Treatment of COVID-19 with Chloroquine: Implication for Malaria Chemotherapy Using ACTs in Disease Endemic Countries	Quashie,  NB,  Duah-Quashie, et al	J Trop Pediatr	Commentary/Editorial| Commentaire/Éditorial
Editorial Perspective: Rethinking child and adolescent mental health care after COVID-19	Raballo,  A,  Poletti, et al	J Child Psychol Psychiatry	Commentary/Editorial| Commentaire/Éditorial
La crise de la COVID-19 changera-t-elle notre faÇon de faire de l'Économie ? analyses et prÉvisions Économiques par temps de crise	Ragot,  X	Revue de l'OFCE	Commentary/Editorial| Commentaire/Éditorial
The Toughest Triage in Decision Impacts: Rethinking Scientific Evidence for Environmental and Human Health Action in the Times of Concomitant Global Crises	Raimi,  Morufu,  Gift, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Response to: ‘Correspondence on ‘Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19- associated cytokine storm syndrome: results of the CHIC study’’ by Calvo-Aranda et al	Ramiro,  S,  Mostard, et al	Annals of the Rheumatic Diseases	Commentary/Editorial| Commentaire/Éditorial
Mental health, society and COVID-19	Ramsay,  M	British Journal of Nursing	Commentary/Editorial| Commentaire/Éditorial
Coronavirus Disease 2019 (COVID-19) Vaccines and Pregnancy: What Obstetricians Need to Know	Rasmussen,  SA,  Kelley, et al	Obstet Gynecol	Commentary/Editorial| Commentaire/Éditorial
PMC7744275; Essential interpretations of bioinformatics in COVID-19 pandemic	Ray,  M,  Sable, et al	Meta Gene	Commentary/Editorial| Commentaire/Éditorial
Migrant workers, essential work, and COVID-19	Reid,  A,  Rhonda-Perez, et al	Am J Ind Med	Commentary/Editorial| Commentaire/Éditorial
A Queer Approach to Understanding LGBT Vulnerability during the COVID-19 Pandemic	Reid,  G,  Ritholtz, et al	Politics and Gender	Commentary/Editorial| Commentaire/Éditorial
Vaccination in the Philippines: experiences from history and lessons for the future	Reyes,  Msgl,  Dee, et al	Hum Vaccin Immunother	Commentary/Editorial| Commentaire/Éditorial
Drug ontology for the public mexican health system	Reyes-Peña,  C,  Vidal, et al		Commentary/Editorial| Commentaire/Éditorial
Urology practice in the COVID-19 era: Learning to adapt	Reyes-Vallejo,  L	Revista mexicana de urologia	Commentary/Editorial| Commentaire/Éditorial
Covid-19: A therapeutic approach based on pathophysiological staging	Ribas,  CD	Open Respiratory Medicine Journal	Commentary/Editorial| Commentaire/Éditorial
COVID-19 infection and dermatologic surgery: management in a dermo-oncology center in a high-risk pandemic area	Ribero,  S,  Caliendo, et al	Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia	Commentary/Editorial| Commentaire/Éditorial
COVID-19 has changed our society as well as Dermatology	Ring,  J	Journal of the European Academy of Dermatology and Venereology	Commentary/Editorial| Commentaire/Éditorial
Better alone than in bad company: Contact and contagion with isolated and recently contacted indigenous people in brazil and challenges for their protection and health care	Rodrigues,  D,  Albertoni, et al	Saude e Sociedade	Commentary/Editorial| Commentaire/Éditorial
Postgraduate education before the new circumstances created by covid-19	Rodríguez,  GJB,  Suárez, et al	Revista Cubana de Educacion Medica Superior	Commentary/Editorial| Commentaire/Éditorial
Economic situation, fiscal policy and pandemic in colombia	Rodríguez,  JA	Revista de Economia Institucional	Commentary/Editorial| Commentaire/Éditorial
Diagnostic and therapeutic aspects in the infection by SARS-CoV-2, (COVID-19) in Pediatrics	Rodriguez-Herrera,  R,  Rivera-Diaz, et al	Acta Pediatrica de Mexico	Commentary/Editorial| Commentaire/Éditorial
Cardiac involvement in COVID-19: does echocardiography matter? Response	Rodríguez-Santamarta,  M,  Minguito-Carazo, et al	Revista espanola de cardiologia	Commentary/Editorial| Commentaire/Éditorial
Letter to the Editor "Oral manifestations associated with COVID-19"	Rohani,  B	Oral Dis	Commentary/Editorial| Commentaire/Éditorial
PsPAPASH syndrome, secondary amyloidosis and COVID-19: Live to tell	Romaní,  J,  Perdiguer-Gómez, et al	Piel	Commentary/Editorial| Commentaire/Éditorial
Chinese philosophy of life, relational ethics and the COVID-19 pandemic	Rošker,  JS	Asian Philosophy	Commentary/Editorial| Commentaire/Éditorial
Looking beyond COVID-19	Roskruge,  M	Kai Tiaki Nursing New Zealand	Commentary/Editorial| Commentaire/Éditorial
Viral pandemics of the last four decades: Pathophysiology, health impacts and perspectives	Roychoudhury,  S,  Das, et al	International Journal of Environmental Research and Public Health	Commentary/Editorial| Commentaire/Éditorial
The ethnography of the global after globalization	Rudnyckyj,  D,  Whitington, et al	HAU: Journal of Ethnographic Theory	Commentary/Editorial| Commentaire/Éditorial
President's Message: Song and Spirit at the Confluence of WHO's 2020 The Year of the Nurse and Midwife and the Coronavirus Pandemic	Russell,  GP	J Transcult Nurs	Commentary/Editorial| Commentaire/Éditorial
Neuromyelitis optica spectrum disorders and covid-19	Sá,  MJ	Sinapse	Commentary/Editorial| Commentaire/Éditorial
Face Mask Detection System	Sachdeva,  Rajat	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Is hypertension without any other comorbidities an independent predictor for COVID-19 severity and mortality?	Salazar,  MR	J Clin Hypertens (Greenwich)	Commentary/Editorial| Commentaire/Éditorial
Exposure risk assessment of the municipal waste collection activities during COVID-19 pandemic	Salvaraji,  L,  Jeffree, et al	Journal of Public Health Research	Commentary/Editorial| Commentaire/Éditorial
COVID-19 (SARS-CoV-2): The legacy of the disease in relation to urology	Sánchez-Núñez,  JE,  Reyes-Vallejo, et al	Revista mexicana de urologia	Commentary/Editorial| Commentaire/Éditorial
Initial lessons from the COVID-19 pandemic	Santos,  BS	Revista de Economia Institucional	Commentary/Editorial| Commentaire/Éditorial
The truth must prevail: citizens' rights to know the truth during the era of COVID-19	Sarmiento,  PJD,  Yap, et al	J Public Health (Oxf)	Commentary/Editorial| Commentaire/Éditorial
Is newly diagnosed diabetes as frequent as preexisting diabetes in COVID-19 patients?	Sathish,  T,  Cao, et al	Diabetes and Metabolic Syndrome: Clinical Research and Reviews	Commentary/Editorial| Commentaire/Éditorial
Designing feature application for user experience to censor inappropriate scene in indonesia	Satryoko,  A,  Runturambi, et al		Commentary/Editorial| Commentaire/Éditorial
PMC7461469; Lessons Learned: Pediatric Telemental Health in a Rural Medical Center in the Age of SARS-CoV-2	Satti,  K,  Ojugbele, et al	J Rural Health	Commentary/Editorial| Commentaire/Éditorial
Centralized Multi-agent Mobile Robots SLAM and Navigation for COVID-19 Field Hospitals	Sayed,  AS,  Ammar, et al		Commentary/Editorial| Commentaire/Éditorial
Pediatric Infectious Disease Specialists - An Answer to Social Media Misinformation on COVID-19	Scaggs Huang,  F,  Spearman, et al	J Pediatric Infect Dis Soc	Commentary/Editorial| Commentaire/Éditorial
Coping strategies during the COVID-19 pandemic in nursing school	Schirmer,  J,  Balsanelli, et al	ACTA Paulista de Enfermagem	Commentary/Editorial| Commentaire/Éditorial
A DKMS (German Bone Marrow Donor Center) view on cryopreservation of unrelated donor stem cell products during the COVID-19 pandemic	Schmidt,  AH,  Buk, et al	Am J Hematol	Commentary/Editorial| Commentaire/Éditorial
Os efeitos da pandemia da Covid-19 sobre o agronegócio e a alimentação	Schneider,  S,  Cassol, et al	Estudos Avancados	Commentary/Editorial| Commentaire/Éditorial
Pediatric Inflammatory Multisystem Syndrome and Rheumatic Diseases During SARS-CoV-2 Pandemic	Schvartz,  A,  Belot, et al	Frontiers in Pediatrics	Commentary/Editorial| Commentaire/Éditorial
‘Like 9/11 on steroids’: AI in the age of coronavirus	Scott,  K		Commentary/Editorial| Commentaire/Éditorial
Covid-19 and food segurity	Segovia,  E	Revista de la Facultad de Agronomia	Commentary/Editorial| Commentaire/Éditorial
Covid-19 and mental health	Shah,  AA	Psychiatric Annals	Commentary/Editorial| Commentaire/Éditorial
Opsoclonus Myoclonus Ataxia Syndrome in the Setting of COVID-19 Infection	Shah,  PB,  Desai, et al	Neurology	Commentary/Editorial| Commentaire/Éditorial
Challenges of SARS-CoV-2 prevention in flights, suggested solutions with potential on-site diagnosis resembling cancer biomarkers and urgency of travel medicine	Shaimoldina,  A,  Xie, et al	European review for medical and pharmacological sciences	Commentary/Editorial| Commentaire/Éditorial
PMC7665670; International travel during the COVID-19 pandemic: implications and risks associated with 'travel bubbles'	Sharun,  K,  Tiwari, et al	J Travel Med	Commentary/Editorial| Commentaire/Éditorial
Management of immune checkpoint therapy for patients with cancer in the face of COVID-19	Shen,  C,  Li, et al	Journal for ImmunoTherapy of Cancer	Commentary/Editorial| Commentaire/Éditorial
Overinterpretation of the antiviral results for human coronavirus strain 229E (HCoV-229E) relative to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)	Shewale,  JG,  Ratcliff, et al	J Med Virol	Commentary/Editorial| Commentaire/Éditorial
Understanding the immunopathogenesis of COVID-19: Its implication for therapeutic strategy	Shimizu,  Y	World Journal of Clinical Cases	Commentary/Editorial| Commentaire/Éditorial
PMC7769895; Responding to a COVID-19 Outbreak at a Long-Term Care Facility	Shrader,  CD,  Assadzandi, et al	J Appl Gerontol	Commentary/Editorial| Commentaire/Éditorial
Physical inactivity and health inequality during coronavirus: A novel opportunity or total lockdown?	Shur,  NF,  Johns, et al	BMJ Open Sport and Exercise Medicine	Commentary/Editorial| Commentaire/Éditorial
A fragilidade econômica e financeira na pandemia do Sars-Covid-19	Silber,  SD	Estudos Avancados	Commentary/Editorial| Commentaire/Éditorial
Opportunities and Risks for Research Biobanks in the COVID-19 Era and beyond	Simeon-Dubach,  D,  Henderson, et al	Biopreservation and Biobanking	Commentary/Editorial| Commentaire/Éditorial
Parkinson disease in the context of the covid-19 pandemics	Simões,  RM,  Vale, et al	Sinapse	Commentary/Editorial| Commentaire/Éditorial
COVID-19 in Community-Based LTCFs: Successful Strategies for Abatement at one VA Healthcare System	Simon,  SR,  Lysaght, et al	J Am Geriatr Soc	Commentary/Editorial| Commentaire/Éditorial
Clinico-epidemiological characteristics of Kawasaki-like disease in paediatric patients with COVID-19: a protocol for rapid living systematic review	Sinha,  A,  Nayak, et al	BMJ Open	Commentary/Editorial| Commentaire/Éditorial
Reflection: Making kin with sourdough during a pandemic	Siragusa,  L	Food and Foodways	Commentary/Editorial| Commentaire/Éditorial
Hard lockdown and a "health dictatorship": Australia's lucky escape from covid-19	Smith,  P	Bmj	Commentary/Editorial| Commentaire/Éditorial
Immunohistochemical expression of angiotensin-converting enzyme 2 in minor salivary glands during SARS-CoV-2 infection	Soares,  CD,  Mosqueda-Taylor, et al	Journal of medical virology	Commentary/Editorial| Commentaire/Éditorial
PMC7262071; Telehealth Policies Impacting Federally Qualified Health Centers in Face of COVID-19	Sodhi,  M	J Rural Health	Commentary/Editorial| Commentaire/Éditorial
"School of hard knocks" - what can mental health researchers learn from the COVID-19 crisis?	Sonuga-Barke,  E	J Child Psychol Psychiatry	Commentary/Editorial| Commentaire/Éditorial
Othering and deprioritizing older adults’ lives: Ageist discourses during the COVID-19 pandemic	Søraa,  RA,  Manzi, et al	Europe's Journal of Psychology	Commentary/Editorial| Commentaire/Éditorial
Sicurezza e bioetica ai tempi del Covid-19	Spagnolo,  AG	Medicina e Morale	Commentary/Editorial| Commentaire/Éditorial
About the fair balance of competing rights in the context of the covid-19 pandemic	Spîrchez,  GB,  Bârsan-Pipu, et al	Transylvanian Review of Administrative Sciences	Commentary/Editorial| Commentaire/Éditorial
Neurology and COVID-19: Time to burn the candle at both ends	Srivastava,  A,  Garg, et al	Annals of Indian Academy of Neurology	Commentary/Editorial| Commentaire/Éditorial
Between Geometry and Technical Drawing - Didactic Interactive and Animated Drawing Teaching Tools of the DIAD-TOOLS Project	Sroka-Bizoń,  M,  Dudzik, et al		Commentary/Editorial| Commentaire/Éditorial
Organisational injustice from the COVID-19 pandemic: a hidden burden of disease	Stanhope,  J,  Weinstein, et al	Perspect Public Health	Commentary/Editorial| Commentaire/Éditorial
Winning Together: 'C3-T2' Updated COVID-19 Infographic	Stawicki,  S,  De Wulf, et al	Journal of Emergencies, Trauma and Shock	Commentary/Editorial| Commentaire/Éditorial
Rule of law in tough times – a case study on the romanian sanctioning policy during the covid-19 pandemic	Ștefan,  L,  Grama, et al	Transylvanian Review of Administrative Sciences	Commentary/Editorial| Commentaire/Éditorial
PMC7543597; Travel restrictions and lockdown during the COVID-19 pandemic-impact on notified infectious diseases in Switzerland	Steffen,  R,  Lautenschlager, et al	J Travel Med	Commentary/Editorial| Commentaire/Éditorial
Response to Goldberg and Villeneuve re: An ecological analysis of long-term exposure to PM(2.5) and incidence of COVID-19 in Canadian Health Regions	Stieb,  DM,  Evans, et al	Environ Res	Commentary/Editorial| Commentaire/Éditorial
Awareness and answers for the public health concern of violence in older adults: An introduction to special issue	Stripling,  A,  Dautovich, et al	Aggression and Violent Behavior	Commentary/Editorial| Commentaire/Éditorial
PMC7537303; A cross-section of UK prostate cancer diagnostics during the coronavirus disease 2019 (COVID-19) era - a shifting paradigm?	Stroman,  L,  Cathcart, et al	BJU Int	Commentary/Editorial| Commentaire/Éditorial
Viral Fundamentals: Riding the Corona Waves in India	Subramaniam,  B	Religion Compass	Commentary/Editorial| Commentaire/Éditorial
Social Inclusion of Older Adults during COVID-19 Pandemic	Subudhi,  Rabi,  Das, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Sustaining primary care teams in the midst of a pandemic	Sullivan,  EE,  Phillips, et al	Isr J Health Policy Res	Commentary/Editorial| Commentaire/Éditorial
Content validity for the research instrument regarding ethical issues in handling the covid-19 pandemic	Suryadi,  T,  Kulsum, et al	Periodico Tche Quimica	Commentary/Editorial| Commentaire/Éditorial
Conceptual Issues in COVID-19 Pandemic: An Example of Global Catastrophic Risk	Szocik,  K	Camb Q Healthc Ethics	Commentary/Editorial| Commentaire/Éditorial
The First Wave of COVID-19 Pandemic: Experiences from Bangladesh	Tabassum,  Tahani,  Farzana, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Simulations and virtual learning supporting clinical education during the COVID 19 pandemic [response to letter]	Tabatabai,  S	Advances in Medical Education and Practice	Commentary/Editorial| Commentaire/Éditorial
The influence of diabetes and hypertension on outcome in COVID-19 patients: Do we mix apples and oranges?	Tadic,  M,  Cuspidi, et al	J Clin Hypertens (Greenwich)	Commentary/Editorial| Commentaire/Éditorial
Skin lesions in children with COVID-19-associated multisystem inflammatory syndrome	Tamrazova,  OB,  Osmanov, et al	Pediatriya - Zhurnal im G.N.Speranskogo	Commentary/Editorial| Commentaire/Éditorial
SARS-CoV-2 and aerosols—Arguing over the evidence	Tang,  JW	Journal of virological methods	Commentary/Editorial| Commentaire/Éditorial
Start of the year note 2021	Tárnok,  A	Cytometry A	Commentary/Editorial| Commentaire/Éditorial
PMC7744017; Framework for PESTEL dimensions of sustainable healthcare waste management: Learnings from COVID-19 outbreak	Thakur,  V	J Clean Prod	Commentary/Editorial| Commentaire/Éditorial
Negative impact of COVID-19 lockdown on papilloedema and idiopathic intracranial hypertension	Thaller,  M,  Tsermoulas, et al	J Neurol Neurosurg Psychiatry	Commentary/Editorial| Commentaire/Éditorial
Covid-19 and smoking	Thomas,  D,  Berlin, et al	Archives des Maladies du Coeur et des Vaisseaux - Pratique	Commentary/Editorial| Commentaire/Éditorial
One Year Later, How Does COVID-19 Affect Children?	Thompson,  LA,  Rasmussen, et al	JAMA Pediatr	Commentary/Editorial| Commentaire/Éditorial
Racial Health Disparities, COVID-19, and a Way Forward for US Health Systems	Tiako,  MJN,  Forman, et al	J Hosp Med	Commentary/Editorial| Commentaire/Éditorial
Adaptive and turbulent governance. Ways of governing that foster resilience. the case of the covid-19 pandemic	Țiclău,  T,  Hințea, et al	Transylvanian Review of Administrative Sciences	Commentary/Editorial| Commentaire/Éditorial
Évaluation de la pandÉmie de COVID-19 sur l'Économie mondiale	Timbeau,  X	Revue de l'OFCE	Commentary/Editorial| Commentaire/Éditorial
Hospital in the air: Royal Flying Doctor Service retrievals and challenges before, during and after, Australia's COVID-19 lockdown in 2020	Ting,  J	Internal Medicine Journal	Commentary/Editorial| Commentaire/Éditorial
Strategy for Shortened Manufacturing cycle of mold tool in extremely short terms	Todorov,  G,  Sofronov, et al		Commentary/Editorial| Commentaire/Éditorial
Whether and how does the crisis-induced situation change e-leadership in the public sector? Evidence from lithuanian public administration	Toleikienė,  R,  Rybnikova, et al	Transylvanian Review of Administrative Sciences	Commentary/Editorial| Commentaire/Éditorial
The representation of LGBTQ+ individuals on television in Lebanon	Touma Sawaya,  A,  Beayno, et al	Journal of Gay and Lesbian Mental Health	Commentary/Editorial| Commentaire/Éditorial
Air pollution in four Indian cities during the Covid-19 pandemic	Tripathi,  A	International Journal of Environmental Studies	Commentary/Editorial| Commentaire/Éditorial
The interrelationships between antimicrobial resistance, COVID-19, past, and future pandemics	Ukuhor,  HO	Journal of Infection and Public Health	Commentary/Editorial| Commentaire/Éditorial
Distance Learning in Technical Education on Example of Estonia and Poland	Vaimann,  T,  Stepien, et al		Commentary/Editorial| Commentaire/Éditorial
Joining European Scientific Forces to Face Pandemics	Vasconcelos,  MH,  Alcaro, et al	Trends in microbiology	Commentary/Editorial| Commentaire/Éditorial
COMPLEX REASONS TO TREAT COVID-19-RELATED FEVER	Verd,  S,  Ponce-Taylor, et al	Journal of paediatrics and child health	Commentary/Editorial| Commentaire/Éditorial
PMC7255722; COVID-19 and the difficulty of inferring epidemiological parameters from clinical data - Authors' reply	Verity,  R,  Okell, et al	Lancet Infect Dis	Commentary/Editorial| Commentaire/Éditorial
Environmental, safety and economic risks of Covid-19 pandemic in petroleum industries: A prospective	Verma,  C,  Alrefaee, et al	Journal of Petroleum Science and Engineering	Commentary/Editorial| Commentaire/Éditorial
Plexiglas & covid-19: Stop building walls!	Voix,  J	Canadian Acoustics - Acoustique Canadienne	Commentary/Editorial| Commentaire/Éditorial
Mental wellbeing of frontline healthcare workers during COVID-19 pandemic in Qatar	Wadoo,  O,  Latoo, et al	Asian J Psychiatr	Commentary/Editorial| Commentaire/Éditorial
Successful Role of Smart Technology to Combat COVID-19	Waheed,  A,  Shafi, et al		Commentary/Editorial| Commentaire/Éditorial
A rapid response and treatment service for care homes: a case study	Waldon,  M	Br J Community Nurs	Commentary/Editorial| Commentaire/Éditorial
Authors' reply re: Maternal transmission of SARS-COV-2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis	Walker,  KF,  O'Donoghue, et al	Bjog	Commentary/Editorial| Commentaire/Éditorial
Reflective practice: the essential competency for health systems and healthcare practitioners during the COVID-19 pandemic	Walpola,  R,  Lucas, et al	Reflective Practice	Commentary/Editorial| Commentaire/Éditorial
Daily Routine and Access to Care: Initial Patient Reported Experiences at a German Lung Cancer Center during the COVID-19 Pandemic	Walter,  J,  Sellmer, et al	Respiration	Commentary/Editorial| Commentaire/Éditorial
Knowledge management based on information technology in response to COVID-19 crisis	Wang,  WT,  Wu, et al	Knowledge Management Research and Practice	Commentary/Editorial| Commentaire/Éditorial
PMC7755574; COVID-19 and the agri-food system in the United States and Canada	Weersink,  A,  von Massow, et al	Agric Syst	Commentary/Editorial| Commentaire/Éditorial
Change in ectopic pregnancy presentations during the covid-19 pandemic	Werner,  S,  Katz, et al	Int J Clin Pract	Commentary/Editorial| Commentaire/Éditorial
Setting Acceptance Criteria for a National Flocked Swab for Biological Specimens during the COVID-19 Pandemic	Whulanza,  Y,  Supriadi, et al	International Journal of Technology	Commentary/Editorial| Commentaire/Éditorial
THE IMPACT OF THE TRANSFORMATIONAL LEADERSHIP CLIMATE ON EMPLOYEE JOB SATISFACTION DURING THE COVID-19 PANDEMIC IN THE INDONESIAN BANKING INDUSTRY	Winasis,  S,  Djumarno, et al	PalArch's Journal of Archaeology of Egypt/ Egyptology	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and Methylene Blue	Wiwanitkit,  V	Braz J Cardiovasc Surg	Commentary/Editorial| Commentaire/Éditorial
Infusion of Convalescent Plasma is associated with Clinical Improvement in Critically Ill Patients with Covid-19: A Comment	Wiwanitkit,  V	Revista de Investigacion Clinica	Commentary/Editorial| Commentaire/Éditorial
A Protocol for Safe Head and Neck Reconstructive Surgery in the COVID-19 Pandemic	Wong,  S,  Payton, et al	Plastic and Reconstructive Surgery - Global Open	Commentary/Editorial| Commentaire/Éditorial
Evaluation of SARS-CoV-2 antibody titers and potency for convalescent plasma donation: a brief commentary	Wouters,  E,  Steenhuis, et al	Vox Sang	Commentary/Editorial| Commentaire/Éditorial
Erratum: Diagnostic accuracy of chest computed tomography scans for suspected patients with COVID-19: Receiver operating characteristic curve analysis (JMIR Public Health and Surveillance (2020) 6:4 (e19424) DOI: 10.2196/19424)	Wu,  L,  Jin, et al	JMIR Public Health and Surveillance	Commentary/Editorial| Commentaire/Éditorial
A hidden pandemic	Yaghy,  A,  Dalvin, et al	AMA Journal of Ethics	Commentary/Editorial| Commentaire/Éditorial
Unexpected increase of the compliance rate of transfusion requisition form after the COVID-19 outbreak	Yang,  L,  Feng, et al	Transfusion Clinique et Biologique	Commentary/Editorial| Commentaire/Éditorial
Patients with upper gastrointestinal foreign bodies are more likely to consult later and with a higher rate of hospitalization during the COVID-19 pandemic	Yu,  M,  Liu, et al	Rev Esp Enferm Dig	Commentary/Editorial| Commentaire/Éditorial
Iterative Monitoring of Temperatures in Confinement for Early Screening of SARS-CoV-2 Infections	Yuan,  S,  Jiang, et al	Frontiers in Medicine	Commentary/Editorial| Commentaire/Éditorial
COVID-19: Iran's Actions to Deal with and Control the Pandemic and Practical Suggestions	Zarchi,  MKR,  Shafaghat, et al	Journal of Environmental Health and Sustainable Development	Commentary/Editorial| Commentaire/Éditorial
Hospital Inpatient Charges of COVID-19 Diagnostic Tests Ranged from $10 to $1390	Zare,  H,  Bai, et al	Popul Health Manag	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and risk of inflammatory periodontal disease initiation/progression: A hypothesis for future	Zargaran,  M	Journal of Oral Medicine and Oral Surgery	Commentary/Editorial| Commentaire/Éditorial
Open Science to Address COVID-19: Sharing Data to Make Our Research Investment Go Further	Zariffa,  N,  Haggstrom, et al	Ther Innov Regul Sci	Commentary/Editorial| Commentaire/Éditorial
In-hospital 3D Printing to Aid Maxillofacial Surgery during the COVID-19 Pandemic	Zavattero,  E,  Borbon, et al	Plastic and Reconstructive Surgery - Global Open	Commentary/Editorial| Commentaire/Éditorial
The Development of Disaster Nursing in China-from the Spirit of Nightingale to COVID-19	Zhang,  DI,  Zhang, et al	Disaster Med Public Health Prep	Commentary/Editorial| Commentaire/Éditorial
PMC7499648; Countries of origin of imported COVID-19 cases into China and measures to prevent onward transmission	Zhang,  ZB,  Li, et al	J Travel Med	Commentary/Editorial| Commentaire/Éditorial
Operationalizing a PPE reprocessing center	Zimmer,  MM,  Lucas, et al	International Journal of Healthcare Management	Commentary/Editorial| Commentaire/Éditorial
Delays in testing as a source of COVID-19 false-negative results	Zimmer,  R	Canadian Family Physician	Commentary/Editorial| Commentaire/Éditorial
Novel use of an old compound? Urologist‐led Bacille Calmette–Guérin vaccine trials in the prevention of coronavirus disease 2019	Zlotta,  AR	BJU Int	Commentary/Editorial| Commentaire/Éditorial
MATHEMATICAL METHODS OF FIGHTING VS COVID-19	Zulfixarov,  IM,  Xursanbekovich, et al	PalArch's Journal of Archaeology of Egypt/ Egyptology	Commentary/Editorial| Commentaire/Éditorial
COVID-19 – »the perfect storm?«	Zupanc,  TL	Zdravniski Vestnik	Commentary/Editorial| Commentaire/Éditorial
ASH Registry Offers Insights on COVID-19 in Patients with Hematologic Malignancies		Oncologist	Commentary/Editorial| Commentaire/Éditorial
A review of 2020 through Nature’s editorials		Nature	Commentary/Editorial| Commentaire/Éditorial
Urgent Action Needed to Prevent Measles, Polio Resurgence		JAMA - Journal of the American Medical Association	Commentary/Editorial| Commentaire/Éditorial
Avoidable deaths due to infodemic about COVID-19		Journal of paediatrics and child health	Commentary/Editorial| Commentaire/Éditorial
Coronavirus: Tackling other infectious diseases		Science	Commentary/Editorial| Commentaire/Éditorial
2nd Novel Intelligent and Leading Emerging Sciences Conference, NILES 2020			Commentary/Editorial| Commentaire/Éditorial
Proceedings - 2020 3rd International Conference on Artificial Intelligence for Industries, AI4I 2020			Commentary/Editorial| Commentaire/Éditorial
Erratum to: Clinical characteristics of dermatologic manifestations of COVID-19 infection: case series of 15 patients, review of literature, and proposed etiological classification (Int J Dermatol, (2020), 59, (1000–1009), 10.1111/ijd.15030)		International journal of dermatology	Commentary/Editorial| Commentaire/Éditorial
Proceedings of the 3rd International Workshop on Semantic Web Meets Health Data Management, SWH 2020 - co-located with the 19th International Semantic Web Conference, ISWC 2020			Commentary/Editorial| Commentaire/Éditorial
Proceedings of the 17th International Conference on Intellectual Capital, Knowledge Management and Organisational Learning, ICICKM 2020			Commentary/Editorial| Commentaire/Éditorial
IEELM-DTE 2020 - Proceedings of the 4th International Conference on Informatization of Education and E-Learning Methodology: Digital Technologies in Education			Commentary/Editorial| Commentaire/Éditorial
17th International Conference on Economics of Grids, Clouds, Systems, and Services, GECON 2020			Commentary/Editorial| Commentaire/Éditorial
Correction to Lancet Psychiatry 2020; published online Nov 16. https://doi.org/10.1016/S2215-0366(20)30435-1 (The Lancet Psychiatry (2021) 8(1) (58–63), (S2215036620304351), (10.1016/S2215-0366(20)30435-1))		The Lancet Psychiatry	Commentary/Editorial| Commentaire/Éditorial
14th World Congress on Engineering Asset Management, WCEAM 2019			Commentary/Editorial| Commentaire/Éditorial
Proceedings of the 2020 International Symposium on Artificial Intelligence in Medical Sciences, ISAIMS 2020			Commentary/Editorial| Commentaire/Éditorial

Appendix: Process and definitions. 

A daily search for new publications is conducted in PubMed, Scopus, BioRxiv and MedRxiv, SSRN, Research Square, arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2 OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database.  The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google.  Publishers include Lancet, Elsevier, The New England Journal of Medicine, BMJ, Wiley, Springer Nature, ChinaCDCweekly. Additionally the database is cross-referenced with other literature scans and activities by collaborators.  Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa Waddell for additional information: Lisa.Waddell@canada.ca.  References are compiled in a reworks database that has citations since the beginning of the outbreak.  All references can be accessed at this link and by the categories listed below.  The daily scan has also been compiled in an excel sheet and copies can be provided upon request or accessed here.

Category Definitions:

Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely to influence future results.

Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro, attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*

Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.

Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.*  

Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.

Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers. 

Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data.  Surveillance data will likely be number of cases suspected/confirmed, number of deaths, number recovered. *

Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses

Diagnostics / Pathogen detection:  All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.

Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.

Vaccine Research:  Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.

Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.

Public Health interventions*: Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).

Public Health response: Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.

Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC

Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to:  set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.

Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.

Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)

Animal Model: An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the added risk of harming an actual human.

Zoonotic: all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.

Review Literature:  All articles that summarize the published literature can be tagged as a review.  This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*

Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary category.

News articles that have not scientific information.

*Lists are not exhaustive

Annexe: Processus et définitions. 

Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus, BioRxiv and MedRxiv, SSRN, Research Square, arXiv pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV).  La saisie renvoie à des annonces de publication sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google.  Parmi les éditeurs figurent Lancet, Elsevier, The New England Journal of Medicine, BMJ, Wiley, Springer Nature, ChinaCDCweekly.  En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.  Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au : Lisa.Waddell@canada.ca.  Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie.  Toutes les références sont accessibles à partir de ce lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées ici.

Définitions des catégories :

Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats. Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.

Épidémiologie : Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque, le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.

Transmission : Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.

Données cliniques des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.* 

Séquelles à long terme: Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.

Santé mentale: Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.

Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.  Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *

Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.

Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes, etc.

Thérapeutique : Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.

Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.

Priorités de santé publique : Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.

Interventions de santé publique* : Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).

Réponse de la santé publique : Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées à la pandémie.

Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) : Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.

Réponse des soins de santé : Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment :  mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux / stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.

Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)

Modèle animal: Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.

Zoonotic: all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.

Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19

Revue de la documentation :  Tous les articles qui résument les documents publiés peuvent être marqués comme une revue.  Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.

Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.

journaux Articles de presse qui n'ont pas d'informations scientifiques.

* Les listes ne sont pas exhaustives