Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19,
2020-12-10
Good afternoon,
There are 228 citations in today’s scan. 154 were considered primary research or review literature.
Highlights today include:
EPIDEMIOLOGY
·
Liu et al.
report, based on the collected data from 2172 confirmed cases of COVID-19, the incubation period distribution of COVID-19 to vary over ages.
LONG-TERM SEQUELAE
·
Lenehan et al
have found that COVID-19 patients hospitalized after confirmed viral clearance tended to have lower hemoglobin and hematocrit measurements both during their SARS-CoV-2 positive intervals and during the one year prior to COVID-19 diagnosis compared to
patients who have not been rehospitalized after viral clearance. Results suggest that anemia pre-dating or concurrent with SARS-CoV-2 infection may predispose patients to long-term complications of COVID-19.
CLINICAL DATA
·
Pathak et al
integrated a genome-wide association study of COVID-19 hospitalization with mRNA expression, splicing, and protein levels. We identified 27 genes related to inflammation and coagulation pathways whose genetically predicted expression was associated with
COVID-19 hospitalization. Our study highlights putative causal genes impacting COVID-19 severity and symptomology through the host inflammatory response.
·
Amendola et al
described the earliest evidence of SARS-CoV-2 RNA in a patient in Italy. Retrospectively explored a possible etiologic involvement of SARS-CoV-2 in non–measles-linked rash cases. Identified SARS-CoV-2 RNA in an oropharyngeal swab specimen collected from
a child with suspected measles in early December 2019, ≈3 months before the first identified coronavirus disease case in Italy.
IMMUNOLOGY
·
Song et al
examined immune parameters in CSF and blood samples from patients with COVID-19 and significant neurological complications. We found divergent immunological responses in the CNS compartment, including increased levels of IL-12 and IL-12-associated innate
and adaptive immune cell activation. We found increased proportions of B cells in the CSF relative to the periphery and evidence of clonal expansion of CSF B cells. All COVID-19 cases examined had anti-SARS-CoV-2 IgG antibodies in the CSF.
THERAPEUTICS
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Perveen et al observed the repurposing use of remdesivir and favipiravir whether considered as a therapeutic option or not through
survival rate and changes in biomarker during 10-day treatment stay in ICU. They found that remdesivir and favipiravir revealed not much hope in improving prognostic biomarkers, survival rate and disease progression at the initial peak of pandemic in Bangladesh.
DIAGNOSTICS
·
Truong et al.
Found that unsupervised at-home mid-turbinate specimen collection for SARS-CoV-2 testing resulted in~1% of participants using the wrong end of the swab. However, molecular detection of respiratory pathogens and a human biomarker were comparable between
specimens collected from the handle of the swab and those collected correctly. Older participants were more likely to use the swab backwards.
PUBLIC HEALTH RESPONSE
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Germani et al analyzed the behavior of anti-vaccination supporters on the platform Twitter identifying that anti-vaccination supporters, in comparison to pro-vaccination
supporters, share conspiracy theories and make use of emotional language. We propose to strategically target the anti-vaccination community online through policies that aim at halting the circulation of false information about vaccines.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley Otten, Drew
Greydanus, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark, Catherine Card, Ruey Su, Paul McLaren
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics /
Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance,
Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, Immunologie,
économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Using Smartwatch Data to Detect COVID-19 Cases Early |
Abbasi, J |
Jama |
Public health interventions*| Interventions de santé publique |
This ongoing Digital Engagement and Tracking for Early Control and Treatment (DETECT) study suggests that wearable
sensor data combined with self-reported symptoms might aid in the early detection of coronavirus disease 2019 (COVID-19). The researchers analyzed data from 333 participants who entered both symptoms and test results into the DETECT smartphone app, which also
collected heart rate, sleep, and activity data from the individuals’ commercial wearable devices. Fifty-four participants reported testing positive for COVID-19. A model that analyzed both sensor data and symptoms more accurately discriminated between positive
and negative cases than one that considered symptoms alone |
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Akkaya-Kalayci, T, Kothgassner, et al |
Int J Environ Res Public Health |
Mental Health |
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This study investigated the psychological well-being and changes in the mental-health state of young people living in Austria and Turkey. The native Turks
indicated higher "anxiety" (ps < 0.010), lower "vitality" (ps < 0.011), and lower "general health" (ps < 0.011) than native Austrians or Austrian migrants and increased "depression" (p = 0.005) and lower "self-control" (p = 0.022), than Austrian migrants.
Moreover, 50.9% of native Turks reported a decrease in their mental health status, compared to 31.1% of native Austrians and 23.7% of Austrian migrants. Participants with financial problems (OR = 1.68) and prior mental health problems (i.e., already in treatment
by the time of COVID-19, OR = 5.83) reported a higher probability for a worsening in their mental health status. |
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Incidence, Characteristics, Laboratory Findings and Outcomes in Acro-Ischemia in COVID-19
Patients |
Alonso, MN, Mata-Forte, et al |
Vascular health and risk management |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study intends to quantify the incidence of acro-ischemic lesions in COVID-19 infected adult subjects in our population, describing clinical patterns
and associated findings. The overall rate of acro-ischemic findings in COVID-19 patients was 1.2% 0.6% for outpatients and 2.9% for hospitalized (ICU and non-ICU patients)], but the observed incidence for acro-ischemia in ICU patients was remarkably higher
(23.0%, p<0.001). Four different clinical patterns of acroischemia were observed: atypical Raynaud´s phenomenon (ARP), (4); pseudo-pernio (PP), (5); severe microcirculatory ischemia with preserved pulse (SMI), (6); and dry gangrene with arteriosclerosis obliterans
(AO), (9). Kendall´s τ correlation with lung disease severity was 0.877 (95% CI, 0.756 to 0.968); p<0.01). ARP individuals were predominantly female, while SMI appeared lately in elderly hospitalized subjects with better prognosis. AO occurred in patients
with more comorbidity and younger than those with SMI. |
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Alshalan, R, Al-Khalifa, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
This study aims to identify hate speech related to the COVID-19 pandemic posted by Twitter users in the Arab region and to discover the main issues discussed
in tweets containing hate speech. The analysis also revealed that the majority of hate tweets (8385/11,743, 71.4%) contained a low level of hate based on the score provided by the CNN. This study identified Saudi Arabia as the Arab country from which the
most COVID-19 hate tweets originated during the pandemic. |
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Evidence of SARS-CoV-2 RNA in an Oropharyngeal Swab Specimen, Milan, Italy, Early
December 2019 |
Amendola, A, Bianchi, et al |
Emerg Infect Dis |
Clinical data| Données cliniques |
We identified severe acute respiratory syndrome coronavirus 2 RNA in an oropharyngeal swab specimen collected from a child with suspected measles in early
December 2019, ≈3 months before the first identified coronavirus disease case in Italy. This finding expands our knowledge on timing and mapping of novel coronavirus transmission pathways. |
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The Impact of Social Support on Public Anxiety amidst the COVID-19 Pandemic in China |
Ao, Y, Zhu, et al |
Int J Environ Res Public Health |
Mental Health | |
This study investigated the anxiety of the Chinese public and its relationship with social support during the early
stage of the COVID-19 pandemic, thereby providing empirical support for interventions on improving the public's mental health. The study showed that 19.8%, 68.5%, and 11.1% of the respondents suffered mild anxiety, moderate anxiety, and severe anxiety, respectively.
Significant differences are reported in state anxiety between people with different household incomes. There are significant differences in trait anxiety and state anxiety between different social support groups. Social support and trait anxiety are negatively
correlated. Social support and state anxiety are negatively correlated. Social support affects state anxiety both directly and indirectly (through the mediation of trait anxiety). |
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Practice of COVID-19 Preventive Measures and Its Associated Factors among Students
in Ghana |
Apanga, PA, Kamal Lettor, et al |
Am J Trop Med Hyg |
Public Health response| Interventions de santé publique |
This study assessed factors associated with practice of COVID-19 preventive measures among senior high school students
in the Bawku Municipality, Ghana. An estimated 31.5% of the students wore a face mask often or always. Students who reported that COVID-19 can be transmitted via droplets from the nose or mouth and students who reported that asymptomatic persons can transmit
the virus had higher odds of wearing a face mask. However, students who reported that COVID-19 was not deadly were associated with lower odds of wearing a face mask. Handwashing/hand sanitizing was practiced by 49.5% of students. Students in the technical
program compared to the science program and those who reported that COVID-19 was not deadly had lower odds of handwashing/hand sanitizing. An estimated 46.2% of students practiced social distancing. Students who reported that COVID-19 can be transmitted via
droplets from the nose or mouth were positively associated with social distancing. |
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Type I Interferon Signature in Chilblain-Like
Lesions Associated with the COVID-19 Pandemic |
Aschoff, R, Zimmermann, et al |
Dermatopathology (Basel) |
Clinical data| Données cliniques |
In biopsies from three patients with acral partially ulcerating chilblain lesions that occurred associated to the COVID-19
pandemic, this study analysed the expression of type I interferon induced proteins and signal transduction kinases. Histology demonstrated perivascular and periadnexal lymphohistiocytic infiltrates and endothelial dominated MxA-staining, as well as pJAK1 activation.
Findings demonstrate induction of the type I IFN pathway in lesional sections of COVID-19-associated chilblain-like lesions. |
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Factors Affecting Covid-19 Vaccination Intent Among
Iranians: COVID-19 Vaccination Acceptance |
Askarian, Mehrdad, Fu, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
A cross-sectional survey was conducted to evaluate COVID-19 vaccination intent and associated factors based on the
Health Belief Model. Among the 4,933 respondents, 24.7% were healthcare workers, and 64.2% intended to accept COVID-19 vaccination. The odds of COVID-19 vaccination intent were three or more times greater among those with a greater belief in COVID-19 vaccine
effectiveness, lower concerns about vaccine safety, and greater exposure to cues to vaccinate, including from doctors. |
|
Augustin, TL, Hajbabaie, et al |
Molecules (Basel, Switzerland) |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, we present a fragment-guided approach using ZINCPharmer, where 17 active fragments known to bind to the catalytic
centre of the SARS-CoV-2 main protease (SARS-CoV-2 Mpro) were used as pharmacophore queries to search the ZINC databases of natural compounds and natural derivatives. This search yielded 134 hits that were then subjected to multiple rounds of in silico analyses,
including blind and focused docking against the 3D structure of the main protease. We scrutinised the poses, scores, and protein-ligand interactions of 15 hits and selected 7. The scaffolds of the seven hits were structurally distinct from known inhibitor
scaffolds, thus indicating scaffold novelty. Our work presents several novel scaffolds as potential candidates for experimental validation against SARS-CoV-2 Mpro. |
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Aviran, E, Laks, et al |
The Israel Medical Association journal : IMAJ |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study aimed to describe the effects of the COVID-19 outbreak on admissions of surgical patients from the ED and
characteristics of urgent operations performed. The combined cohort included 606 patients. There were 25% fewer admissions during the COVID-19 period (P < 0.0001). The COVID-19 cohort had a longer time interval from onset of symptoms (P < 0.001) and presented
in a worse clinical condition as expressed by accelerated heart rate (P = 0.023), leukocyte count disturbances (P = 0.005), higher creatinine, and CRP levels (P < 0.001) compared with the control cohort. More COVID-19 patients required urgent surgery (P =
0.03) and length of ED stay was longer (P = 0.003). |
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Bal, Antonin, Trabaud, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We conducted a prospective study in healthcare workers (n=296) of the University Hospital of Lyon, France. Serum samples
(n=296) collected six months after disease onset were tested using three commercial assays: the Wantai Ab assay detecting total antibodies against the receptor binding domain (RBD) of the S protein, the bioMerieux Vidas assay detecting IgG to the RBD and the
Abbott Architect assay detecting IgG to the N protein. The neutralising antibody (NAb) titre was also determined for all samples with a virus neutralisation assay (VNA) using live virus. The positivity rate was 100% with the Wantai assay, 84.8% with the bioMerieux
assay and 56.4% with the Abbott assay. Only 51% of HCWs were positive for the presence of NAb. Less than 10 % of HCWs NAb titer of 80. At a neutralising titer of 80, the area under the curves IC 95%] was 0.71 0.62-0.81], 0.75 0.65-0.85] and 0.95 0.92-0.97]
for Wantai, Abbott and Vidas respectively. Commercial assays detecting antibodies against the N protein must not be used in long-term seroprevalence surveys while the Wantai assay could be very useful for this purpose. VNA should remain the gold standard to
assess the protective antibody response, but some commercial assays could be useful for first-line screening of long-term presence of NAb. |
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Barh, Debmalya, Tiwari, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Here, using a similar multi-omics-based bioinformatics approach and three-ways of analysis, we identified the symptoms,
comorbid conditions, and short, mid and possible long-term complications of COVID-19 with ~90% precision. In our analysis (i) we identified 27 parent, 170 child, and 403 specific conditions associated with COVID-19. Based on the accuracy (~90%) of this analysis,
long presence of SARS-CoV-2 RNA in human, and our previously proposed genetic remittance assumption, we hypothesize that all the identified comorbid conditions including the short-long-mid and mid-long non-communicable diseases (NCDs) could also be long-term
consequences in COVID-19 survivors and warrants long-term observational studies. |
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Batıbay, Sevilay, Ulucaköy, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
In this study, our aim was to detect the frequency of Covid-19 infection among our rheumatology out-patients and to
investigate how patient follow-up differed during Covid-19 pandemic. There were 7 patients diagnosed with Covid-19, none of them had severe respiratory complications or death. During the pandemic, numerous patients with rheumatic diseases are left without
monitoring. Of the patients, 56% using HCQ experienced problems in medication supply. There is no increased risk detected in rheumatology patients related to severe Covid-19 infection. |
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Stress-related emotional and behavioural impact
following the first COVID-19 outbreak peak |
Benjamin, Asaf, Kuperman, et al |
medRxiv |
Mental Health |
|
We examined the behavioural and mental health impact of the pandemic in Israel using an online survey. We collected
12,125 responses from 4,933 adult respondents during six weeks encompassing the end of the first outbreak and the beginning of the second. Our findings show that inequalities in mental-health burden associated with the COVID-19 pandemic are relevant also following
the initial outbreak, and highlight the environmental context and its importance in understanding individual ability to cope with the long-term stressful challenges of the pandemic. |
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Boyce, DM, Thomashow, et al |
Chronic Obstr Pulm Dis |
Healthcare Response | Réponse des soins de santé |
OBJECTIVES: To investigate telemedicine adoption, emergency room avoidance, and related characteristics of patients
with chronic obstructive pulmonary disease (COPD) with and without exacerbations since the COVID-19 pandemic began. RESULTS: More than half of respondents (157, 64%), indicated that they started using telemedicine in 2020. Forty-seven percent of respondents
had at least one exacerbation since January 1, 2020. Respondents who had at least one exacerbation in 2020 were more likely to start using telemedicine in 2020 than respondents who did not report any exacerbation in 2020. |
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Buesching, Gilbert, Zhang, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We compared the rehabilitation outcomes between COVID-19 patients with pneumonia and other patients with common pneumonia
to assess their rehabilitation efficacies. Covid-19 patients had similar performances at discharge in 6MWT, CRQ, and 4.2-point higher in FIM compared to the control group. No differences in the outcomes were found between severe and critical COVID-19 patients.
There was no significant difference in the 6MWT at discharge between the two subgroups, indicating that the physical functioning outcome of our rehabilitation program is similar between critical and severe COVID-19 patients. |
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Camerotto, A, Sartorio, et al |
Int J Environ Res Public Health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
The aim of this study was to describe timing and event management by ULSS 5 in preventing the propagation of infection
within the timeframe spanning from 21 February to 30 June. Although the gender ratio in the Rovigo health district is higher than other districts under consideration, the number of observed cases was lower than expected according to linear regression. The
low number of COVID-19 cases per 10,000 people observed in the district of Rovigo is not only due to its low population density. |
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Caruso, F, Singh, et al |
Int J Mol Sci |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We describe the potential anti coronavirus disease 2019 (COVID-19) action of the methide quinone inhibitor, celastrol.
In this study, we describe celastrol interaction with the active site of the COVID-19 virus main protease. We also include a crystal structure analysis of celastrol and disclose its uncommon antioxidant capability when scavenging the superoxide radical, by
using DFT methods. We observe a correlation between antioxidant property and protease inhibition, through a specific interaction of celastrol with the Cys145 amino acid, assisted by proton transfer at the active site. |
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Age-related differences in the perception of COVID-19 emergency during the
Italian outbreak |
Ceccato, I, Palumbo, et al |
Aging Ment Health |
Public Health response| Interventions de santé publique |
We compared young (18–29 years), middle-aged (30–50 years), and older (65–85 years) adults’ self-reported emotions,
attitudes toward the emergency, and compliance with governmental rules. Older adults showed lower negative emotions than young and middle-aged adults. Also, older adults were more confident about COVID-related information received, more favorable toward the
restrictive measures, and perceived lower underestimation of the emergency compared to the other age groups. However, older people anticipated a longer time for the emergency to resolve. No age-related differences in compliance with the rules emerged. |
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Chen, S |
DNA Cell Biol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study described here was to develop and validate novel SARS-CoV-2 proteins binding human mRNAs (SPBRs)
signature to predict overall survival (OS) in hepatocellular carcinoma (HCC). Multivariate regression analysis demonstrated the signature was an independent predictor of HCC. Moreover, the signature presented an excellent diagnostic power in differentiating
HCC and normal tissues. Gene set enrichment analysis demonstrated that high-risk group was closely enriched in cell cycle, DNA replication, microRNAs in cancer, and cytokine–cytokine receptor interaction. |
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Genomic and evolutionary comparison between SARS-CoV-2 and other human coronaviruses |
Chen, Z, Boon, et al |
J Virol Methods |
Coronavirology| Coronavirologie |
To better understand the evolutionary position of SARS-CoV-2, we first examined the phylogenetic relationship of the
subgenus Sarbecoviruses within the genus Betacoronaviruses using the concatenated nucleotide sequences of 12 ORFs/genes. In consistent with previous reports, SARS-CoV-2 shares sequence similarities with a bat coronavirus isolate, similar to the genomic differences
between SARS-CoV and bat SARS-like CoVs, implying potential zoonotic transmission of SARS-CoV-2 from bats as their natural reservoirs to humans through unknown intermediate hosts. |
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Optimizing SARS-CoV-2 molecular diagnostic using
N gene target: insights about reinfection |
Contelli Klein, Raphael, Fabres Klein, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We compared the fitness of two primers sets to the SARS-CoV-2 N gene in the molecular diagnosis of COVID-19. Both targets,
N1 and N2 displayed similar fitness during testing with no differences between Ct or measurable viral genome copies. In addition, we verified security ranges Cts related to positive diagnostic with Ct above 35 value failuring in 66,6% after retesting of samples.
Our data suggest that it is secure to use just one primer set to the N gene to identify SARS-CoV-2 in samples and the labs should be careful to set positive samples in high Ct values using high cutoffs. |
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Contact Screening for Healthcare Workers Exposed to Patients with COVID-19 |
Coppeta, L, Somma, et al |
Int J Environ Res Public Health |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
The aim of this study was to evaluate the rate of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection
among HCWs exposed to patients with COVID-19 in relation to the main determinants of exposure. We found that close contact (within 2 m for 15 min or more) was not statistically related to contagion. Regarding the use of personal protective equipment (PPE),
only the use of facial masks was inversely related to the chance of becoming infected (p < 0.01). This data show that unprotected contacts between HCWs should be considered a major route of HCW contagion, suggesting that the use of facial masks should be implemented
even in settings where known patients with COVID-19 are not present. |
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Inflated false-negative rates in pooled RT-PCR
tests of SARS-CoV-2 |
Daon, Yair, Huppert, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Pooling is a popular strategy for increasing SARS-CoV-2 testing throughput. A common pooling scheme is Dorfman pooling:
test N individuals simultaneously. If the first test is positive - retest each individual. Using a probabilistic model, we analyze the false-negative rate (i.e., the probability of a negative result for an infected individual) of Dorfman pooling . We show
that one can expect a 60-80% increase in false-negative rates under Dorfman pooling, for reasonable parameter values. Moreover, we show that the false-negative rates under Dorfman pooling increase when the prevalence of infection decreases. |
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Coding Errors in Study of Factors Associated With SARS-CoV-2 Antibodies in Health
Care Personnel |
Davidson, KW |
Jama |
Epidemiology| Épidémiologie Immunology | Immunologie |
Our cohort study determined the prevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
among 40 329 health care professionals in the Northwell Health System in the New York City area. We also analyzed associations of seroprevalence with demographic variables, primary work location and type, and suspicion of exposure to SARS-CoV-2. We reported
a 13.7% prevalence of SARS-CoV-2 antibodies among these health care professionals. We found in the fully adjusted model that a previous positive polymerase chain reaction (PCR) test result and a reported high suspicion of virus exposure were associated with
seroprevalence. |
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Díaz-Avalos, C, Juan, et al |
Int J Environ Res Public Health |
Epidemiology| Épidémiologie |
The principal objective of this article is to assess the possible association between the number of COVID-19 infected
cases and the concentrations of fine particulate matter (PM(2.5)) and ozone (O(3)), atmospheric pollutants related to people's mobility in urban areas, taking also into account the effect of meteorological conditions. . The results emphasize that all the
components used in designing the model contribute to improving the predicted values and can be included in designing similar real-world data (RWD) models. We found only a weak association between PM(2.5) and ozone concentrations with COVID-19 infected cases. |
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Dietzen, A, Ide, et al |
Journal of pediatric rehabilitation medicine |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to examine telehealth utilization and satisfaction among pediatric physiatrists. There
was a significant reported increase in telehealth utilization since COVID-19 from 14.5% to 97.4%. Eighty-two percent of participants reported feeling comfortable utilizing telehealth, 77% felt confident in the quality of the care provided, and 91% believed
patients were satisfied with telehealth visits. |
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Diorio, C, McNerney, et al |
Blood Adv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We hypothesized that complement activation plays an important role in SARS-CoV-2 infection in children and sought to
understand if TMA was present in these patients. A high proportion of tested children with SARS-CoV-2 infection had evidence of complement activation and met clinical and diagnostic criteria for TMA. |
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Dolveck, F, Strazzulla, et al |
Braz J Infect Dis |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
This study reported the results of an urgent pre-hospital intervention in eight French nursing homes. Comparison between
periods (before vs after intervention) showed a significant decrease in number of new deaths (83/770; 11% vs 35/687; 5%, p = 0.0001) and new COVID-19 cases (348/770; 45% vs 123/422; 29%, p < 0.001). The urgent pre-hospital intervention by a multidisciplinary
task force achieved mortality reduction during COVID-19 outbreak in nursing homes. Pre-hospital intervention is a valid alternative to hospitalization in case of hospital saturation. |
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COVID-19 in Children With Cancer: A Single Low-Middle Income Center Experience |
Ebeid, FSE, Ragab, et al |
J Pediatr Hematol Oncol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to measure the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection among hospitalized children with cancer and to detect the associated clinical manifestations and outcomes. Pediatric cancer patients with COVID-19 were mainly asymptomatic or with mild symptoms. A high index of suspicion and regular screening with
nasopharyngeal swab in asymptomatic hospitalized cancer patients is recommended. |
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Eder, M, Strassl, et al |
Wien Klin Wochenschr |
Clinical data| Données cliniques |
In this case report we present a rare case of a patient with multiple risk factors for severe coronavirus disease (COVID
19) in whom intensive glucocorticoid treatment due to incipient nephrotic syndrome coincided with SARS-CoV‑2 infection. Despite this high baseline risk profile and the use of glucocorticoids the patient developed only mild disease including IgG SARS-CoV‑2
seroconversion. |
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COVID-19 in Renal Transplant Recipients: Case Series and a Brief Review of Current Evidence |
Elhadedy, MA, Marie, et al |
Nephron |
Clinical data| Données cliniques |
We report 8 cases of kidney transplant recipients infected with COVID-19 (median age = 48.5 years; range = 21–71 years),
including 4 males and 4 females. Overall, 1 patient was managed as an outpatient, the remaining 7 required hospital admission, 1 of them referred to the intensive therapy unit. |
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Containment measures limit environmental effects
on COVID-19 early outbreak dynamics |
Ficetola, Gentile Francesco, Rubolini, et al |
medRxiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
We assessed the impact of environmental factors (temperature, humidity and air pollution) on the global patterns of
COVID-19 early outbreak dynamics during January-May 2020, controlling for several key socio-economic factors and airport connections. We showed that during the earliest phase of the global outbreak (January-March), COVID-19 growth rates were non-linearly
related to climate, with fastest spread in regions with a mean temperature of ca. 5 degrees, and in the most polluted regions. However, environmental effects faded almost completely when considering later outbreaks, in keeping with the progressive enforcement
of containment actions. Accordingly, COVID-19 growth rates consistently decreased with stringent containment actions during both early and late outbreaks. |
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Alkaloids: Therapeutic Potential against Human Coronaviruses |
Fielding, BC, da Silva Maia Bezerra Filho, et al |
Molecules (Basel, Switzerland) |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study, in silico studies showed an affinity of the 11 alkaloids investigated for binding to the receptor-binding
domain of the SARS-CoV-2 spike protein, putatively preventing it from binding to the host cell. Lastly, several mechanisms for the known anti-coronavirus activity of alkaloids were discussed, showing that the alkaloids are interesting compounds with potential
use as bioactive agents against SARS-CoV-2. |
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Fischer, DavidS, Ansari, et al |
medRxiv |
Coronavirology| Coronavirologie Immunology | Immunologie |
Here, we used single-cell RNA sequencing to identify and profile SARS-CoV-2-reactive T cells from Coronavirus Disease
2019 (COVID-19) patients. We characterized transcriptional signatures of currently and previously activated SARS-CoV-2-reactive T cells, and showed correspondence with phenotypes of T cells from the respiratory tract of patients with severe disease in the
presence or absence of virus in independent cohorts. |
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Persisting Neutralizing Activity to SARS-CoV-2 over Months in Sera of COVID-19 Patients |
Flehmig, B, Schindler, et al |
Viruses |
Clinical data| Données cliniques Immunology | Immunologie |
Several new serological methods to examine these parameters were developed, validated and applied in three patients
of a family which underwent an ambulatory course of COVID-19 for six months. The virus load had almost completely disappeared after about four weeks. Serum IgA levels to the S1-RBD-protein and, to a lesser extent, to the N-protein, peaked about three weeks
after clinical disease onset but declined soon thereafter. IgG levels rose continuously, reaching a plateau at approximately six weeks, and stayed elevated over the observation period. Virus-neutralizing activity reached a peak about 4 weeks after disease
onset but dropped slowly. The longitudinal associations of virus neutralization and the serological immune response suggest immunity in patients even after a mild clinical course of COVID-19 |
|
The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in
COVID-19 Patients |
Fois, AG, Paliogiannis, et al |
Molecules |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We performed a retrospective observational study to explore the capacity of different complete blood cell count (CBC)-derived
inflammation indexes to predict in-hospital mortality in this group. Non-survivors had significantly higher AISI, dNLR, NLPR, NLR, SII, and SIRI values when compared to survivors. Similarly, Kaplan-Meier survival curves showed significantly lower survival
in patients with higher AISI, dNLR, MLR, NLPR, NLR, SII, and SIRI. However, after adjusting for confounders, only the SII remained significantly associated with survival (HR = 1.0001; 95% CI, 1.0000-1.0001, p = 0.029) in multivariate Cox regression analysis. |
|
Exiting from Lockdowns: Early Evidence from Reopenings in Europe |
Franks, JeffreyR, Gruss, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
This paper introduces a novel daily database of sectoral reopening measures in Europe during the first-wave and documents
that country plans differed significantly in terms of timing, pace, and sequencing of sectoral reopening measures. We then show that reopenings led to a recovery in mobility-a proxy for economic activity-but at the cost of somewhat higher infections. However,
the experience with reopening reveals some original dimensions of this trade-off. First, the increase in COVID-19 infections after reopening appears less severe in fatality rates. Second, a given reopening step is associated with a worse reinfection outcome
in countries that started reopening earlier on the infection curve or that opened all sectors at a fast pace in a relatively short time. |
|
The anti-vaccination infodemic on social media:
a behavioral analysis |
Germani, Federico, Biller-Andorno, et al |
medRxiv |
Public Health response| Interventions de santé publique |
We analyzed the behavior of anti-vaccination supporters on the platform Twitter. Here we identify that anti-vaccination
supporters, in comparison to pro-vaccination supporters, share conspiracy theories and make use of emotional language. We show that the movement's success relies on a strong sense of community, based on the contents produced by a small fraction of profiles,
with the community at large serving as a sounding board for anti-vaccination discourse to circulate online. Based on these results, we propose to strategically target the anti-vaccination community online through policies that aim at halting the circulation
of false information about vaccines. |
|
Ghosh, R, Chakraborty, et al |
J Biomol Struct Dyn |
Therapeutics| Thérapeutique |
Polyphenols that qualified the pharmacological parameters (indigo, sinigrin, hesperetin and daidzein) and two well-known
Mpro inhibitors (N3 and lopinavir) were subjected to molecular docking studies. Two of them (sinigrin and hesperetin) were selected by comparing their binding affinities with N3 and lopinavir. Sinigrin and hesperetin interacted with the two most important
catalytic residues of Mpro (His41 and Cys145). Molecular dynamics studies further revealed that these two Mpro-polyphenol complexes are more stable and experience less conformational fluctuations than Mpro-N3/lopinavir complex. The Mpro-hesperetin complex
was more compact and less expanded than Mpro-sinigrin complex. These findings were additionally validated by MM-GBSA analysis. As a whole, our study revealed that these two polyphenols may be potent SARS CoV-2 Mpro inhibitors and may possibly be considered
for COVID-19 treatment. |
|
|
Gijzen, M, Shields-Zeeman, et al |
Int J Environ Res Public Health |
Mental Health |
|
The current study explored these effects in the context of the COVID-19 pandemic after relaxation of governmental measures.
An online survey was administered among a representative sample of the Dutch population (n = 1519) in June 2020, ten weeks after the peak of COVID-19 had passed, and five weeks after restrictions were relaxed. Participants were asked about mental health, adverse
events during COVID-19, and about any positive effects of the pandemic. Most participants (80%, n = 1207) reported no change in mental health since the COVID-19 pandemic. This was also the case among respondents who had experienced an adverse event. Protective
factors of mental health were being male and high levels of positive mental well-being. Risk factors were emotional loneliness and the experience of adverse life events. Social loneliness was positively associated with stable mental health, stressing the importance
of meaningful relationships. Note that 58% of participants reported positive effects of the pandemic, the most common of which were rest, working from home, and feeling more socially connected. In summary, 10 weeks after the start of the crisis, and 5 weeks
after relaxation of the restrictions, most people remained stable during the crisis, and were even able to report positive effects. |
|
|
Gonçalves, Marcelo Rodrigues, dos Reis, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
We aimed to assess the magnitude of the associations of social distancing and mask use with laboratory-confirmed infection
by SARS-CoV-2 in adults living in Porto Alegre, Brazil, a city with 1,483,771 inhabitants. In logistic regression analyses of 271 cases and 1396 controls adjusted for age, sex, race, educational attainment, income, household size and pandemic moment, those
reporting moderate to greatest adherence to social distancing had between 59% (OR=0·41; 95%CI 0·24-0·70) and 75% (OR=0·25; 0·15-0·42) lower odds of becoming infected, compared to those reporting very little adherence. Lesser out-of-household exposure reduced
odds between 52% (OR=0·48; 0·29-0·77) and 75% (OR=0·25; 0·18-0·36), compared to going out every day all day. In a subsample of controls with data on mask use and cases of equivalent pandemic moment (198 cases and 420 controls), mask use reduced odds of infection
by 87% (OR=0·13; 0·04-0·36). |
|
|
Theoretical Epidemic Laws Based on Data of COVID-19
Pandemic |
Guo, Junke |
medRxiv |
Epidemiology| Épidémiologie |
Here we show that almost all COVID-19 evolution can be modeled by three innovative epidemic laws. Specifically, based
on the world COVID-19 data, we first divide an epidemic curve into three phases: an exponential growth phase, an exponential decay phase, and a constant endemic phase. We next integrate the growth and the decay phases into the first epidemic law with interventions
as a model parameter. This law is completely opposite to the Richards generalized logistic function in terms of intervention measures. We then combine the first epidemic law with the endemic phase to form the second epidemic law, which makes the curve of cumulative
cases increase linearly as time tends to infinity. The third epidemic law states if an epidemic is composed of multiple epidemic waves, the superposition principle applies. These laws were confirmed by the COVID-19 data from 18 countries including undeveloped,
developing and developed countries. |
|
Hahn, F, Wangen, et al |
Viruses |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We established an analysis system for assessing the antiviral potency of IMU-838 and DHODH-directed back-up drugs in
cultured cell-based infection models. By the use of SARS-CoV-2-specific immunofluorescence, Western blot, in-cell ELISA, viral yield reduction and RT-qPCR methods, we demonstrated the following: (i) IMU-838 and back-ups show anti-SARS-CoV-2 activity at several
levels of viral replication, i.e., protein production, double-strand RNA synthesis, and release of infectious virus; (ii) antiviral efficacy in Vero cells was demonstrated in a micromolar range (IMU-838 half-maximal effective concentration, EC50, of 7.6 ±
5.8 µM); (iii) anti-SARS-CoV-2 activity was distinct from cytotoxic effects (half-cytotoxic concentration, CC50, >100 µM); (iv) the drug in vitro potency was confirmed using several Vero lineages and human cells; (v) combination with remdesivir showed enhanced
anti-SARS-CoV-2 activity; (vi) vidofludimus, the active determinant of IMU-838, exerted a broad-spectrum activity against a selection of major human pathogenic viruses. These findings strongly suggest that developmental DHODH inhibitors represent promising
candidates for use as anti-SARS-CoV-2 therapeutics. |
|
|
Hamer, SarahA, Pauvolid-Correa, et al |
bioRxiv |
zoonoses |
The natural infections and epidemiological roles of household pets in SARS-CoV-2 transmission are not understood. We
conducted a longitudinal study of dogs and cats living with at least one SARS-CoV-2 infected human in Texas and found 47.1% of 17 cats and 15.3% of 59 dogs from 25.6% of 39 households were positive for SARS-CoV-2 via RT-PCR and genome sequencing or neutralizing
antibodies. Virus was isolated from one cat. The majority (82.4%) of infected pets were asymptomatic. Re-sampling of one infected cat showed persistence of viral RNA at least 32 d-post human diagnosis (25 d-post initial test). Across 15 antibody-positive animals,
titers increased (33.3%), decreased (33.3%) or were stable (33.3%) over time. A One Health approach is informative for prevention and control of SARS-CoV-2 transmission. |
|
|
Hasan, MT, Hossain, et al |
medRxiv |
Mental Health |
|
This study aims to investigate the levels of anxiety and depressive symptoms and to identify associated factors among
Bangladeshi physicians during the COVID-19 outbreak. The survey was completed by 412 Bangladeshi physicians. The findings revealed that, in terms of standardized HADS cut-off points, the prevalence of anxiety and depressive symptoms among physicians was 67.72%
and 48.5% respectively. Risk factors for higher rates of anxiety or depressive symptoms were: being female, physicians who had experienced COVID-19 like symptoms during the pandemic, those who had not received incentives, those who used self-funded PPE, not
received adequate training, lacking perceived self-efficacy to manage COVID -19 positive patients, greater perceived stress of being infected, fear of getting assaulted/humiliated, being more connected with social media, having lower income levels to support
the family, feeling more agitated, less than 2 hours of leisure activity per day and short sleep duration. All these factors were found to be positively associated with anxiety and depression in unadjusted and adjusted statistical models. |
|
|
Engineered receptor binding domain immunogens elicit
pan-coronavirus neutralizing antibodies |
Hauser, BlakeM, Sangesland, et al |
bioRxiv |
Coronavirology| Coronavirologie Immunology | Immunologie |
Effective countermeasures are needed against emerging coronaviruses of pandemic potential, similar to severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Designing immunogens that elicit broadly neutralizing antibodies to conserved viral epitopes on the major surface glycoprotein, spike, such as the receptor binding domain (RBD) is one potential approach. Here,
we report the generation of homotrimeric RBD immunogens from different sarbecoviruses using a stabilized, immune-silent trimerization tag. We find that that a cocktail of homotrimeric sarbecovirus RBDs can elicit a neutralizing response to all components even
in context of prior SARS-CoV-2 imprinting. Importantly, the cross-neutralizing antibody responses are focused towards conserved RBD epitopes outside of the ACE-2 receptor-binding motif. This may be an effective strategy for eliciting broadly neutralizing responses
leading to a pan-sarbecovirus vaccine. |
|
Prognostic Factors of COVID-19 Infection in Elderly Patients: A Multicenter Study |
Hwang, J, Ryu, et al |
J Clin Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to investigate the prognostic factors in elderly patients with COVID-19. Overall, 340 elderly patients with
COVID-19 were enrolled in 3 hospitals in Daegu, South Korea. activities of daily living (ADL) impairment, fever, and initial CRP were poor prognostic factors in elderly patients with COVID-19. |
|
Ismail, SharifA, Saliba, et al |
The Lancet Infectious Diseases |
Epidemiology| Épidémiologie Transmission |
We estimated the rate of SARS-CoV-2 infection and outbreaks among staff and students in educational settings during
the summer half-term (June–July, 2020) in England. There were 113 single cases of SARS-CoV-2 infection, nine coprimary cases, and 55 outbreaks. The risk of an outbreak increased by 72% (95% CI 28–130) for every five cases per 100 000 population increase
in community incidence (p<0·0001). Staff had higher incidence than students (27 cases [95% CI 23–32] per 100 000 per day among staff compared with 18 cases [14–24] in early years students, 6·0 cases [4·3–8·2] in primary schools students, and 6·8 cases [2·7–14]
in secondary school students]), and most cases linked to outbreaks were in staff members (154 [73%] staff vs 56 [27%] children of 210 total cases). Probable direction of transmission was staff to staff in 26 outbreaks, staff to student in eight outbreaks,
student to staff in 16 outbreaks, and student to student in five outbreaks. |
|
|
Johannßen, Dirk, Biemann, et al |
arXiv |
Public Health response| Interventions de santé publique |
We present psychologically validated social unrest predictors and replicate scalable and automated predictions for
the social media unrest. We employ this model to investigate a change of language towards social unrest during the COVID-19 pandemic by comparing established psychological predictors on samples of tweets from spring 2019 with spring 2020. The results show
a significant increase of the conflict indicating psychometrics. |
|
|
Malfunctioning Temporary Hemodialysis Catheters
in Patients with COVID-19 |
Kanitra, JJ, Power, et al |
J Vasc Surg |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A total of 48 patients with a mortality rate of 71% were identified. Temporary Hemodialysis Catheter (THDC) malfunction
occurred in 31.3% of patients. Thirty-seven patients (77.1%) received heparin locking, 22 (45.8%) received systemic anticoagulation and 38 (79.1%) received VTE prophylaxis. Overall rate of THDC malfunction was lower at a trend level of significance, with heparin
vs. saline locking (24.3% vs. 54.6%, p=0.058). The likelihood of THDC malfunction in the heparin locked group is lower than all other groups (Hazards ratio [HR]= 0.07, 95% CI [0.01, 0.45], p=0.005). The rate of malfunction in patients with subcutaneous heparin
(SQH) 7,500 units three times daily (TID) is significantly lower than of the rate for patients receiving none (HR=0.03, 95% CI [0.001, 0.74], p=0.032). A trend level significant association was found for SQH 5,000 units vs none (p=0.417) and SQH 7,500 vs 5,000
units (p=0.059). Systemic anticoagulation did not affect THDC malfunction rate (p=0.240). Higher D-dimer levels were related to greater mortality (HR=3.28, 95% CI [1.16, 9.28], p=0.025), but were not significantly associated with THDC malfunction (HR=1.79,
95% CI [0.42, 7.71], p=0.434). |
|
Karahan Yilmaz, S, Eskici, et al |
Public Health Nutr |
Mental Health |
|
Participants showed different levels of depression symptoms during the pandemic period. Especially carbohydrate food
consumption increased, physical activity status and sleep patterns changed due to the increased time spent sitting and lying. |
|
|
Adaptive Sampling for Estimating Distributions: A Bayesian Upper Confidence Bound Approach |
Kartik, Dhruva, Sood, et al |
arXiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Adaptive sampling protocols are proposed for estimating SARS-CoV-2 seroprevalence in various groups such as location
and ethnicity. The effectiveness of this strategy is discussed using data obtained from a seroprevalence survey in Los Angeles county. |
|
Katsouras, C, Karapanayiotides, et al |
Eur J Neurol |
Healthcare Response | Réponse des soins de santé |
The study was conducted in three geographically and demographically representative COVID‐19 referral university hospitals
in Greece. We found a greater relative reduction of stroke admissions (51% [35 vs 71]; incidence rate ratio [IRR]: 0.49, p=0.001) compared with acute coronary syndrome (ACS) admissions (27% [123 vs 168]; IRR: 0.73, p=0.009) during the COVID‐19 outbreak (p=0.097).
Fewer older (>65 years) patients (Stroke: 34.3 vs 45.1%, OR: 0.64, p=0.291; ACS: 39.8 vs 54.2%, OR: 0.56, p=0.016) were admitted during the COVID‐19 compared with the control period. Hospitalisation rates both for stroke and ACS were reduced during the COVID‐19
outbreak in a country with strict social distancing measures, low COVID‐19 incidence and low population mortality. |
|
|
Evaluation of hand hygiene and onset of hand eczema after the outbreak of SARS-CoV-2
in Munich |
Kendziora, B, Guertler, et al |
Eur J Dermatol |
Public Health response| Interventions de santé publique |
Objective: To evaluate changes in the frequency of hand washing and hand care, the onset of hand eczema (HE) and risk
factors associated with HE since the outbreak of SARS-CoV-2 in Munich in January 2020. After the outbreak of SARS-CoV-2, the frequency of hand hygiene measures increased. A considerably high prevalence of HE symptoms was associated with frequent hand disinfection,
atopic dermatitis and young age. |
|
Khanna, Kritika, Raymond, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
To determine if cystines in the SARS-CoV-2 spike protein maintain a native binding interface that can be disrupted
by drugs that cleave cystines, we tested if thiol-based drugs have efficacy in receptor binding and cell infection assays. We found that thiol-based drugs, cysteamine and WR-1065 (the active metabolite of amifostine) in particular, decrease binding of SARS-CoV-2
spike protein to its receptor, decrease the entry efficiency of SARS-CoV-2 spike pseudotyped virus, and inhibit SARS-CoV-2 live virus infection. |
|
|
Kibret, S, Teshome, et al |
PLoS One |
Mental Health |
|
This study aims to assess the prevalence of anxiety and its associated factors towards the COVID-19 outbreak among
healthcare workers in a Hospital of Ethiopia. Being married, having a chronic illness, having suspected COVID-19 family members, not having access to PPEs, and age greater than or equal to 30 years were identified as risk factors for anxiety of Healthcare
Workers towards COVID-19. |
|
|
Smoking, distress and COVID-19 in England: cross-sectional
population surveys from 2016 to 2020 |
Kock, Loren, Shahab, et al |
medRxiv |
Mental Health |
|
This study examined the prevalence of psychological distress among smokers following the onset of the pandemic compared
with previous years. Between April-July 2016/17 and April-July 2020 in England there were increases in both moderate and severe distress among smokers. The distribution of distress differed between 2016/17 and 2020 and represents a widening of established
inequalities, with increases in distress among socio-economically disadvantaged groups, women and diverging age groups. |
|
Kuo, BJ, Lai, et al |
Radiology |
Clinical data| Données cliniques |
We evaluate the imaging guideline recommendations for COVID-19 from the Fleischner Society and analyze the clinical
utility of chest radiograph screening for asymptomatic or minimally symptomatic patients with COVID-19. In accordance with Fleischner Society recommendations, chest radiograph screening for patients with COVID-19 aged 17-60 with mild or no symptoms is not
indicated unless there is risk of clinical deterioration. |
|
|
Maturation of T and B Lymphocytes in the Assessment of the Immune Status in COVID-19
Patients |
Kwiecień, I, Rutkowska, et al |
Cells |
Clinical data| Données cliniques Immunology | Immunologie |
The aim of the present study was to evaluate maturation of B and T cells in COVID-19 patients with interstitial lesions
on chest X-ray (COVID-19 X-ray (+)), without changes on X-ray (COVID-19 X-ray (−)) and in healthy control. The study group consisted of 23 patients divided on two groups: COVID-19 X-ray (+) n = 14 and COVID-19 X-ray (−) n = 9 and control n = 20. The above
results showed that the assessment of selected cells of B and T lymphocytes by flow cytometry can distinguish patients with COVID-19 and differentiate patients with and without changes on chest X-ray. |
|
Lemus Calderon, JA, Beneyto Martin, et al |
Ann Allergy Asthma Immunol |
Epidemiology| Épidémiologie |
The main objective of our study was to analyze how the SARS-CoV-2 infection has affected patients with asthma in terms
of prevalence, morbidity, hospitalization, and mortality. A total of 6310 patients were diagnosed as having SARS-CoV-2 infection, confirming their positivity by reverse transcriptase polymerase chain reaction. From these, a total of 577 were diagnosed as having
asthma, resulting in a prevalence of 9.14%. |
|
|
Lenehan, Patrick, Ramudu, et al |
medRxiv |
Long-Term Sequelae |
|
We have found that COVID-19 patients hospitalized after confirmed viral clearance tended to have lower hemoglobin and
hematocrit measurements both during their SARS-CoV-2 positive intervals and during the one year prior to COVID-19 diagnosis compared to patients who have not been rehospitalized after viral clearance. Results suggest that anemia pre-dating or concurrent with
SARS-CoV-2 infection may predispose patients to long-term complications of COVID-19. |
|
|
Challenging behavior of nursing home residents during COVID-19 measures in
the Netherlands |
Leontjevas, R, Knippenberg, et al |
Aging Ment Health |
Healthcare Response | Réponse des soins de santé |
A survey and interview of Nursing Home practitioners (psychologists, elderly care physicians, nurse practitioners)
in the Netherlands. Half of the participants reported that their work load increased and work satisfaction worsened during the measures. Different strategies were described to respond to the effects of COVID-19 measures, such as video calls, providing special
areas for residents to meet their loved ones, adjusting activities, and reducing the exposure to negative news. |
|
Lim, Shir Lynn, Woo, et al |
Research Square prepub |
Mental Health |
|
Explore the indirect consequences of COVID-19 on health-related quality of life (HRQoL) of patients with cardiovascular
disease . The COVID-19 pandemic is associated with a significant worsening of the mental health of patients with CVD. |
|
|
In Silico Discovery of Antimicrobial Peptides as an Alternative to Control SARS-CoV-2 |
Liscano, Y, Oñate-Garzón, et al |
Molecules (Basel, Switzerland) |
Coronavirology| Coronavirologie |
Investigated the in silico interaction of antimicrobial peptides with viral structural proteins and host cell ACE2
receptors. The results revealed that two amphibian AMPs, caerin 1.6 and caerin 1.10, had the highest affinity for Sgp proteins while interaction with the ACE2 receptor was reduced. The effective AMPs interacted particularly with Arg995 located in the S2 subunits
of Sgp, which is key subunit that plays an essential role in viral fusion and entry into the host cell through ACE2. |
|
Modeling the Effect of Age on Quantiles of the Incubation Period Distribution
of COVID-19 |
Liu, Xiaohui, Wang, et al |
|
Epidemiology| Épidémiologie |
Based on the collected data from 2172 confirmed cases of COVID-19, the authors found the incubation period distribution
of COVID-19 varies over ages. |
|
Lokhande, KB, Apte, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie |
Report studies on the binding and stability of lectins (NPA, UDA, GRFT, CV-N and wild-type and mutant BanLec) and PRM-A
with the S glycoprotein glycans via docking and MD simulation. MM/GBSA calculations were also performed for docked complexes. Interestingly, stable BanLec mutant (H84T) also showed similar docking affinity and interactions as compared to wild-type BanLec,
thus, confirming that uncoupling the mitogenic activity did not alter the lectin binding activity of BanLec. The stability of the docked complexes, i.e. PRM-A and lectins with SARS-CoV-2 S glycoprotein showed favorable intermolecular hydrogen-bond formation
during the 100 ns MD simulation. |
|
|
Loosen, Alisa Maria, Skvortsova, et al |
medRxiv |
Mental Health |
|
Assessed how obsessive-compulsive (OC), anxiety, and depression symptoms changed throughout the course of the first
pandemic wave in a sample of the general UK public. Depression scores decreased during the first pandemic wave, however, OC symptoms further increased, even after the end of lockdown. These OC symptoms were directly linked to Covid-related information seeking
which gave rise to higher adherence to government guidelines. |
|
|
Mahida, RY, Chotalia, et al |
BMJ open respiratory research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Determine whether patients with SARS-CoV-2 ARDS are clinically distinct, therefore requiring alternative management
strategies, compared with other patients with ARDS. A greater proportion of SARS-CoV-2 patients were from an Asian ethnic group (p=0.002). SARS-CoV-2 patients had lower circulating leucocytes, neutrophils and monocytes (p<0.0001), but higher CRP (p=0.016)
on ICU admission. SARS-CoV-2 patients required a longer duration of mechanical ventilation (p=0.01), but had lower vasopressor requirements (p=0.016). |
|
|
Anxiety amongst physicians during COVID-19: Cross-sectional study in
Pakistan |
Mahmood, Qaisar Khalid, Jafree, et al |
Research Square prepub |
Mental Health |
|
Identify the determinants of anxiety in physicians on duty in coronavirus wards or quarantine centers in Pakistan.
Results revealed significant associations between gender and anxiety. Structural equation modeling identified that high workload contributed to greater exhaustion and greater family strain. Exhaustion, family strain, and feelings of protection significantly
explained anxiety. |
|
On Cancer, COVID-19, and CT Scans: A Monocentric Retrospective Study |
Martini, F, D'Alessio, et al |
J Clin Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We retrospectively reviewed 148 chest CT scans of oncological patients in Italy. In parallel, we analyzed RT-PCR tests
of these 148 patients. Among 32 patients with a diagnosis of COVID-19, 17 patients were asymptomatic or had mild symptoms (53.1%), while 15 developed severe disease (46.8%). The incidence of SARS-CoV-2 infection was 22.9%, the mortality rate was 18.8%. We
did not find any correlation between disease severity and age, sex, smoking, or cardiovascular comorbidities. Remarkably, patients who were on treatment for cancer developed a milder disease than patients who were not on treatment. |
|
Seroprevalence of SARS-CoV-2 Antibodies in Seattle,
Washington: October 2019-April 2020 |
McCulloch, DeniseJ, Jackson, et al |
medRxiv |
Epidemiology| Épidémiologie Immunology | Immunologie |
Estimating prevalence of SARS-CoV-2 antibodies is important to determine disease burden. We tested residual samples
from 763 Seattle-area adults for SARS-CoV-2 antibodies. Prevalence rose from 0% to 1.2% between October 2019-April 2020, suggesting a small percentage of this metropolitan-area cohort had been infected with SARS-CoV-2 at that time. |
|
McGuine, TA, Biese, et al |
J Athl Train |
Mental Health |
|
The objective of this cross-sectional study was to describe the health of athletes during COVID-19-related school closures
and sport cancellations. Females reported a higher prevalence of moderate to severe anxiety symptoms. The prevalence of depression symptoms was highest in team sport (74.1%) and lowest in individual sport (64.9%) participants. The total Pediatric Quality
of Life Inventory score was lowest (worst) for athletes from counties with the highest poverty level. |
|
|
McLaughlin, MJ, Fisher, et al |
Journal of pediatric rehabilitation medicine |
Healthcare Response | Réponse des soins de santé |
After the onset of the Coronavirus pandemic of 2019-2020 (COVID-19), physicians who inject OnabotulinumtoxinA (BoNT-A)
were left with determining risks and benefits in pediatric patients with cerebral palsy. A retrospective chart review of 500 patients identified 256 pediatric patients with cerebral palsy who received an intramuscular BoNT-A injection was done. Resumption
of BoNT-A injections during the time of COVID-19 requires a systematic approach based on risks and potential benefits. Data from this analysis does not show increased risk for patients who received injections. |
|
|
Merino, MD, Oliver-Hernández, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
The purpose of this research was to find out if people experiencing a quarantine are able to appreciate any positive
aspects of it, and to analyze how these responses are categorized and to check if there are differences in levels of well-being according to these categories. There were 243 representative participants of the Spanish population. From the qualitative analysis,
three major categories were extracted: intrinsic orientation, extrinsic orientation, and empty orientation. The quantitative results showed a clear advantage in well-being for the intrinsically oriented group. The group of intrinsic orientation presented a
better coping ability while the group of extrinsic orientation was as little adaptive as the group of empty orientation. |
|
|
Mistry, Sabuj Kanti, Ali, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
Rohingya (Forcefully Displaced Myanmar Nationals or FDMNs) in Bangladesh are at increased risk of COVID-19. This cross-sectional
study aimed to assess the level of misconceptions and the factors associated with it among the older FDMNs in Bangladesh. The most prevalent misconceptions were were related to the prevention of COVID-19, i.e., everyone should wear personal protective equipment
when outside (86.6%), and its prevention by nutritious food (62.5%) and drinking water (59.3%). Other notable misconceptions included the spread of COVID-19 through mosquito bites (42%) and its transmissions only to the non/less-religious person (31.5%). In
regression analyses, memory or concentration problems, communication frequency with social networks, pre-existing conditions, and receiving information from health workers were significantly associated with higher COVID-19 misconceptions. |
|
|
Extended in vitro inactivation of SARS-CoV-2 by
titanium dioxide surface coating |
Mlcochova, Petra, Chadha, et al |
bioRxiv |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
We show tiles coated with TiO2 120 days previously can inactivate SARS-CoV-2 under ambient indoor lighting with 87%
reduction in titres at 1h and complete loss by 5h exposure. TiO2 coatings could be an important tool in containing SARS-CoV-2. |
|
Mondal, M, Sarkar, et al |
Infect Disord Drug Targets |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study intends to evaluate the effectiveness of FDA-approved anti-viral drugs against SARS-CoV-2 through a molecular
docking study. Results revealed that among the conventional antiviral drugs, the protease inhibitors, lopinavir, amprenavir, indinavir, maraviroc, saquinavir, and daclatasvir showed high binding affinity and interacted with amino acid residues of the binding
site. |
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|
Molecular descriptors of some chemicals that prevent COVID-19 |
Mondal, S, De, et al |
Curr Org Synth |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The objective of the present work is to examine the usefulness of the multiplicative degree based indices in quantitative
structure property/activity relationship modeling. To study the indices for chemical structures preventing COVID-19, different combinatorial computation methods are utilized. Explicit expressions of the indices for hydroxychloroquine, remdesivir (GS-5734)
and theaflavin are obtained. As the indices are shown to have remarkable efficiency in quantitative structure property/activity relationship modeling and isomer discrimination, the outcomes can predict different properties and activities of the chemicals under
consideration. |
|
Mostafa, A, Kandeil, et al |
Pharmaceuticals (Basel) |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Herein, we tested the antiviral activity of anti-microbial and anti-inflammatory Food and Drug Administration (FDA)-approved
drugs, commonly prescribed to relieve respiratory symptoms, against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the viral causative agent of the COVID-19 pandemic. Of these FDA-approved antimicrobial drugs, Azithromycin, Niclosamide, and
Nitazoxanide showed a promising ability to hinder the replication of a SARS-CoV-2 isolate, with IC(50) of 0.32, 0.16, and 1.29 µM, respectively. We provided evidence that several antihistamine and anti-inflammatory drugs could partially reduce SARS-CoV-2 replication
in vitro. Furthermore, this study showed that Azithromycin can selectively impair SARS-CoV-2 replication, but not the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The results suggest that Piroxicam should be prescribed in combination with Azithromycin
for COVID-19 patients. |
|
|
Mullur, J, Wang, et al |
Ann Allergy Asthma Immunol |
Clinical data| Données cliniques |
This paper present a case of a patient with a history of CVID and severely low IgG levels owing to a lapse in immunoglobulin
replacement therapy, who died of complications related to COVID-19 despite receiving convalescent plasma and high-dose intravenous immunoglobulin (IVIG). This case presents several considerations in the care of patients with CVID with COVID-19. The patient's
body mass index was 39 kg/m2, and obesity is a known risk factor for severe disease.4 Furthermore, the patient was not receiving regular immunoglobulin replacement therapy in the months leading up to his COVID-19 diagnosis. Although it is unlikely that IVIG
products available during that time would have contained specific antibodies against SARS-CoV-2, they may have contained cross-reactive antibodies for SARS-CoV, Middle East respiratory syndrome coronavirus, or other human coronaviruses that could potentially
provide some protection.5,6 In addition, regular IVIG therapy may have provided additional protection against the sinopulmonary and other bacterial superinfections that complicated the patient's illness. |
|
|
Nasir, M, P |
Research Square prepub |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We observed the repurposing use of remdesivir and favipiravir whether considered as a therapeutic option or not through
survival rate and changes in biomarker during 10-day treatment stay in ICU. The retrospective observational study in a tertiary care hospital dedicated to COVID-19 at Dhaka, Bangladesh was done at the peak of COVID-19 pandemic in Bangladesh. Among the critically
ill patients in ICU, 26 (44.8%) died and 32 (55.2%) were cured during the study period and highest mean duration of stay in ICU was observed (14.33 days and 18.13 days) in FPV-treated patients. Mean of means for all biomarkers CRP (26.0) and d-Dimer (2.64)
was recorded higher in favipiravir treated patients in death cases, but NLR, d-NLR, platelet, PLR was much higher in remdesivir treated patient of both death and improved cases. The severity of disease progression in critically ill COVID-19 patients in ICU
depends on comorbidities and hyper responsive inflammatory or immunological biomarkers to predict. Though the emergency use authorization and repurposing use of different antivirals are still on trial, but remdesivir and favipiravir revealed not much hope
in improving prognostic biomarkers, survival rate and disease progression at the initial peak of pandemic in Bangladesh. |
|
|
Ndieugnou Djangang, N, Peluso, et al |
Microorganisms |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The aim of this study was to assess the diagnostic role of eosinophils count in COVID-19 patients though a retrospective
analysis of patients admitted to our hospital with suspicion of COVID-19. A total of 174 patients was studied. Of those, 54% had positive rRT-PCR for SARS-CoV-2. A chest CT-scan was performed in 145 patients; 71% showed suggestive findings of COVID-19. Eosinophils
on admission had a high predictive accuracy for positive rRT-PCR and suggestive chest CT-scan (area under the receiver operating characteristic-ROC curve, 0.84 (95% CIs 0.78-0.90) and 0.84 (95% CIs 0.77-0.91), respectively). Eosinopenia and high LDH were independent
predictors of positive rRT-PCR, whereas eosinopenia, high body mass index and hypertension were predictors for suggestive CT-scan findings. Eosinopenia on admission could predict positive rRT-PCR test or suggestive chest CT-scan for COVID-19. |
|
|
The Impact of COVID-19 on Women's Physical Activity Behavior and Mental Well-Being |
Nienhuis, CP, Lesser, et al |
Int J Environ Res Public Health |
Mental Health |
|
The objective of this study was to assess whether sex differences exist in physical activity and well-being since COVID-19
and to explore how barriers or facilitators to physical activity may explain these differences. Women were significantly less physically active than men and reported more barriers and fewer facilitators to physical activity and experienced significantly more
generalized anxiety than men. Women who were engaged in less physical activity due to COVID-19 reported significantly lower mental health scores, lower social, emotional and psychological well-being, and significantly higher generalized anxiety, while women
who engaged in more physical activity had improved mental health scores. |
|
Niño-Taravilla, C, Espinosa-Vielma, et al |
Pediatr Rep |
Clinical data| Données cliniques |
We describe a case of Pediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in
an 8-year-old child. The patient developed multiorgan dysfunction, including mixed shock, cardiac dysfunction with myocarditis, pneumonia, acute kidney failure, and gastrointestinal involvement characterized by inflammation of the wall of the bowel and pancreatitis.
After treatment with Tocilizumab and corticoid therapy, he presented clinical improvement and normalization of inflammatory markers. PIMS-TS is a new disease developed in a small percentage of patients, so a high degree of suspicion is necessary to establish
the diagnosis. Supportive care is of paramount importance. The use of Tocilizumab to control the inflammatory response is likely to be beneficial, but the best immunotherapeutic agent has not yet been established. Randomized clinical studies should be run
to determine the best treatment. |
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|
Placing Sensors in Sewer Networks: A System to Pinpoint New Cases of Coronavirus |
Nourinejad, Mehdi, Berman, et al |
SSRN- Lancet prepublication |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In a recent paper, we described two new algorithms, each sequentially opening and testing successive manholes for genetic
remnants, each algorithm homing in on a neighborhood where the infected person or persons are located. This paper extends that work in six important ways: (1) we introduce the concept of in-manhole sensors, as these sensors will reduce the number of manholes
requiring human testing; (2) we present a realistic tree network depicting the topology of the sewer pipeline network; (3) for simulations, we present a method to create random tree networks exhibiting key attributes of a given community; (4) using the simulations,
we empirically demonstrate that the mean and median number of manholes to be opened in a search follows a well-known logarithmic function; (5) we develop procedures for determining the number of sensors to deploy; (6) we formulate the sensor location problem
as an integer nonlinear optimization and develop heuristics to solve it. Our sensor-manhole system, to be implemented, would require at least three additional steps in R&D: (a) an accurate, inexpensive and fast genetic-remnants test that can be done at the
manhole; (b) design, test and manufacture of the sensors; (c) in-the-field testing and fine tuning of an implemented system. |
|
Palmoplantar erythrodysestesia: a diagnostic sign of COVID-19 |
Nuno-Gonzalez, A, Magaletsky, et al |
J Eur Acad Dermatol Venereol |
Clinical data| Données cliniques |
Cutaneous involvement appears in up to 45.65% of COVID‐19 patients, showing different patterns. We report a non‐previously
described finding: palmoplantar erythrodysestesia. |
|
Perceived Stress Due to COVID-19 Pandemic Among Employed Professional Teachers |
Oducado, Ryan Michael, Rabacal, et al |
SSRN- Lancet prepublication |
Mental Health |
|
This descriptive-correlational online survey administered in August 2020 utilized the COVID-19 Perceived Stress Scale
(COVID-19 PSS-10) to assess the COVID-19 perceived stress among employed Filipino teachers. Results demonstrated that more than half of teachers experienced moderate COVID-19 stress. Females experienced significantly higher COVID-19 stress compared to males.
A negative correlation was noted between self-rated health and COVID-19 stress while a positive correlation was found between perceive risk of getting COVID-19 infection and COVID-19 stress. |
|
Criticism of the sentinel model of epidemiological surveillance in COVID-19 |
Ornelas-Aguirre, J, Vidal-Gómez-Alcalá, et al |
Cirugia y cirujanos |
Epidemiology| Épidémiologie |
The objective was to analyze the increase in sentinel cases of COVID-19 in Mexico calculated from the effective number
of reproductions of the infection (Rt) and compare its evolution with that reported by Italy, Spain and the United States of America during the first twenty weeks of evolution of the epidemic. In Mexico, until July 24, 2020, there are a total of 390,516 cases
of COVID-19 and 43,680 deaths from this disease; with the use of Rt to calculate the correction of cases and unidentified deaths, the figure increases to 3,780,195 cases (p = 0.0002) and 211,469 deaths (p = 0.001). This suggests underreporting in the identification
of cases and deaths and is associated with one of the highest case fatality rates in the world for SARS-CoV-2 infection. |
|
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2
infection |
Padmanabhan, P, Desikan, et al |
PLoS Comput Biol |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, we found, surprisingly, that drugs targeting the host serine protease TMPRSS2 and cysteine proteases Cathepsin
B/L pathways, although independent, could display strong synergy in blocking SARS-CoV-2 virus entry. We predicted this synergy first using a mathematical model of SARS-CoV-2 entry and dynamics in vitro. Further, analysing the data using our model, we estimated
the relative usage of the two pathways and found it to vary widely across cell lines, suggesting that targeting both pathways in vivo may be important and synergistic given the broad tissue tropism of SARS-CoV-2. |
|
Pan, Kuan-Yu, Kok, et al |
The Lancet Psychiatry |
Mental Health |
|
In three psychiatry case-control cohorts, we compared the perceived mental health impact and coping and changes in
depressive symptoms, anxiety, worry, and loneliness before and during the COVID-19 pandemic between people with and without lifetime depressive, anxiety, or obsessive-compulsive disorders.People with depressive, anxiety, or obsessive-compulsive disorders are
experiencing a detrimental impact on their mental health from the COVID-19 pandemic, which requires close monitoring in clinical practice. Yet, the COVID-19 pandemic does not seem to have further increased symptom severity compared with their prepandemic levels. |
|
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Integrative analyses identify susceptibility genes
underlying COVID-19 hospitalization |
Pathak, GitaA, Singh, et al |
medRxiv |
Clinical data| Données cliniques |
Here, we integrated a genome-wide association study of COVID-19 hospitalization (7,885 cases and 961,804 controls from
COVID-19 Host Genetics Initiative) with mRNA expression, splicing, and protein levels (n=18,502). We identified 27 genes related to inflammation and coagulation pathways whose genetically predicted expression was associated with COVID-19 hospitalization. Our
study highlights putative causal genes impacting COVID-19 severity and symptomology through the host inflammatory response. |
|
Patt, D, Gordan, et al |
JCO clinical cancer informatics |
Healthcare Response | Réponse des soins de santé |
This study used a large medical claims clearinghouse database representing 5%-7% of the Medicare fee-for-service population
to characterize changes in the utilization of cancer care services and gain insight into the impact of COVID-19 on the US cancer population, including identification of new patients, gaps in access to care, and disruption of treatment journeys. The current
impact of the COVID-19 pandemic on cancer care in the United States has resulted in decreases and delays in identifying new cancers and delivery of treatment. These problems, if unmitigated, will increase cancer morbidity and mortality for years to come. |
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|
Psychological and Livelihood Impacts of COVID-19 on Bangladeshi
Lower Income People |
Paul, A, Nath, et al |
Asia Pac J Public Health |
Mental Health |
|
The objective of this research is to understand the psychological and livelihood-related impacts of coronavirus disease
2019 (COVID-19) on Bangladeshi lower income group people who depend on daily earnings for their living. Due to fear of COVID-19 infection and lack of livelihood means, respondents (76.6%) have been stressed out (overall score 3.19 ± 0.81 on a 4-point Likert-type
scale), and those working in industries (OR = 5.818, P < .01), farmers (OR = 3.029, P < .05), and day laborers (OR = 2.651, P < .05) have been highly stressed. |
|
Protudjer, JLP, Golding, et al |
Ann Allergy Asthma Immunol |
Mental Health |
|
In a mixed-methods study, Canadian mothers of children aged 0 to 8 years with (cases) and without (controls) food allergy
provided demographic data and completed age-appropriate anxiety questionnaires between April 14, 2020, and April 28, 2020. Mothers of children with food allergy reported high anxiety and poor health-related QoL. Yet, qualitatively, day-to-day food allergy
management was better during the pandemic. |
|
|
Raciborski, F, Jankowski, et al |
Int J Environ Res Public Health |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique
Immunology | Immunologie |
This study assessed knowledge of SARS-CoV2 prevention methods and IgG positivity in police employees in Poland. A survey
of 5082 police asked questions related to risk factors, knowledge about SARS-CoV-2, and methods of infection prevention. Knowledge of prevention methods was overall high and police units where compliance with the preventive measures was high had lower IgG
positivity. |
|
|
Raj, V, Park, et al |
Int J Biol Macromol |
Therapeutics| Thérapeutique |
This study aimed to assess the antiviral activity of cannabinoids (CBDs) against SARS-CoV2. They performed virtual
screening for interactions between 32 CBDs and the SARS-CoV-2 Mpro enzyme followed by in vitro screening of 5 top candidates. Of these, two CBDs molecules had more potent antiviral activity compared to lopinavir, chloroquine, and remdesivir. They suggest these
molecules might be used in combination or with other drugs to treat COVID-19 patients. |
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|
Distant Residues Modulate the Conformational Opening
in SARS-CoV-2 Spike Protein |
Ray, Dhiman, Le, et al |
bioRxiv |
Coronavirology| Coronavirologie |
[Preprint] This study used atomistic molecular dynamics simulations to study the correlations between the SARS-CoV2
spike protein receptor binding domain dynamics and physically distant residues in the spike protein. They identify multiple residues exhibiting long-distance coupling with the RBD opening dynamics. They suggest broad spectrum therapeutics could be generated
targeting these key distant regions of the spike protein. |
|
Reiss, S, Franchina, et al |
PLoS One |
Mental Health |
|
This study aimed to explore the pathways from threat perception to preferences of defense strategies using a survey
conducted within the first days of implementing social distancing measures in Austria and Germany. Their results suggest that individuals deal with threat mostly depending on affective state and motivational orientation. |
|
|
Rosser, JI, Röltgen, et al |
Infect Control Hosp Epidemiol |
Epidemiology| Épidémiologie Immunology | Immunologie |
This is a serosurvey of 10,449 asymptomatic healthcare workers in California. A total of 136 people tested positive
for SARS-CoV-2 IgG, including 41 that had previously tested positive by PCR. Associated risk factors were Hispanic ethnicity, working in environmental services/food services/patient transport or having a COVID positive household contact. They conclude that
SARS-CoV2 IgG positivity was more likely attributable to community rather than occupational exposure. |
|
|
Rudra, Sujan, Das, et al |
Research Square prepub |
Epidemiology| Épidémiologie |
This study assessed the survival rate of the patients diagnosed with COVID-19 after symptom onset in 300 patients from
Bangladesh. Death was increased in females, college graduates, unmarried people and people reporting irregular travel. They conclude early diagnosis of COVID-19 can save lives and special attention should be paid to the significant risk groups. |
|
|
Saadati, Najmieh, Afshari, et al |
Research Square prepub |
Mental Health |
|
The aim of this study was to evaluate the health anxiety of pregnant women in Iran during the COVID-19 pandemic. A
demographic and Health Anxiety questionnaire was given to 300 pregnant women in different trimesters. Pregnant women in the third trimester had significantly higher health anxiety scores compared to those in the first trimester. They conclude that this information
should be incorporated into prenatal care. |
|
|
Saha, Sudipta, Feldman, et al |
medRxiv |
Epidemiology| Épidémiologie |
[Preprint] This study investigated neighbourhood-level inequities across cities in the US and Canada for COVID-19 cumulative
case rates, death rates, testing rates and test positivity. They found consistent evidence of social gradients for case, death and positivity rates, with the most privileged neighbourhoods having the lowest rates. Inequities should be considered when implementing
pandemic response efforts. |
|
|
Samantaray, S, Nag, et al |
Asia Pac J Public Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated SARS-CoV-2 infection in the local population of a prime city of Western Rajasthan in India and found
that the co-morbidities like diabetes (54.3%), cardiovascular diseases (28.8%), chronic respiratory conditions (18.4%) are the predominant risk factors for acquiring the infection. The young adult male population from urban area were maximum affected by the
disease. Most common presenting complains were dry cough (65.7%), fever (62.3%) followed by sore throat (24.1%). A declining positive case percentage was found over the study period, though the number of samples received for SARS-CoV-2 testing increased with
time, implying the effectiveness of government policies at community level to spread the outbreak. |
|
|
Sa-ngiamsuntorn, Khanit, Suksatu, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We optimized a high-content imaging platform and the plaque assay for viral output study using the legitimate model
of human lung epithelial cells, Calu-3, to determine anti-SARS-CoV-2 activity of Andrographis paniculata extract and its major component andrographolide. Post-infection treatment of A. paniculata and andrographolide in SARS-CoV-2 infected Calu-3 cells significantly
inhibited the production of infectious virions with the IC50 of 0.036 μg/mL and 0.034 μM. The cytotoxicity profile developed over the cell line representatives of major organs, including liver, kidney, intestine, lung, and brain, showed the CC50 of >100 μg/mL
for A. paniculata extract and 13.2-81.5 μM for andrographolide, respectively, corresponding to the selectivity index over 380. This study provided experimental evidence in favor of A. paniculata and andrographolide for further development as a monotherapy
or in combination with other effective drugs against SARS-CoV-2 infection. |
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|
Simple Questionnaires to Improve Pooling Strategies for SARS-CoV-2 Laboratory Testing |
Schneitler, S, Jung, et al |
Annals of global health |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
To assess the value of a simple questionnaire to guide and further improve pooling strategies for SARS-CoV-2 laboratory
testing. We designed a simple questionnaire, which included questions pertaining to a suggestive clinical symptomatology, recent travel history, and contact with confirmed cases to stratify an individual's pre-test probability of having contracted COVID-19.
Between March 11 and July 5, 2020, we processed 25,978 samples using random pooling (n = 6,012; 23.1%) or questionnaire-based pooling (n = 19,966; 76.9%). The overall prevalence of SARS-CoV-2 was 0.9% (n = 238). Pool positivity (14.6% vs. 1.2%) and individual
SARS-CoV-2 prevalence (3.4% vs. 0.1%) were higher in the random pooling group than in the questionnaire group. The average number of PCR tests needed to obtain the individual result for one participant was 0.27 tests in the random pooling group, as compared
to 0.09 in the questionnaire-based pooling group, leading to a laboratory capacity increase of 73% and 91%, respectively, as compared to single PCR testing. |
|
Schwinger, M, Trautner, et al |
Int J Environ Res Public Health |
Mental Health |
|
The present study seeks to examine whether lockdown measures affected people's well-being; anxiety; depressive symptoms
during the lockdown and whether these effects could be explained by reduced satisfaction of the basic psychological needs of autonomy and relatedness. N = 1086 participants of different ages and educational levels from all over Germany reported strong declines
in autonomy and well-being; small declines in relatedness satisfaction; moderate increases in anxiety and depressive symptoms. These effects were stronger for people with moderate to bad subjective overall health. Latent change modeling revealed that, especially,
decreases in autonomy satisfaction led to stronger decreases in well-being as well as stronger increases in anxiety and depressive symptoms; whereas decreases in relatedness had much weaker effects. |
|
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PCR Test Is Not an Accurate Predictor of Lung Damage in COVID-19 Patients |
Semenova, Yuliya, Maukayeva, et al |
SSRN- Lancet prepublication |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study aimed at evaluation of diagnostic accuracy of PCR test in comparison with chest CT to detect COVID-19 pneumonia.
The study followed a cross-sectional analytical design and relied on the nationwide data on all COVID-19 patients admitted to the hospitals of Kazakhstan between 14 March and 18 April, 2020. PCR test demonstrated reasonable sensitivity (0.8095) but had low
specificity (0.1079) and diagnostic accuracy (0.2707). There is a need to envisage prediction rules to evaluate the pretest probability of infection in order to estimate the post-test probability and to take relevant action in case of unexpected test’s result.
As inaccurate diagnostic tests undermine containment efforts, public input is desired. |
|
Siddiqui, S, Upadhyay, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study was designed to check the antiviral efficacy of N. sativa main phytoconstituents against five potential
targets of SARS-CoV-2 using in silico structure-based virtual screening approach. Ten components showed best binding affinity against two viral proteins viz. N-terminal RNA binding domain of nucleocapsid protein and papain-like protease of SARS-CoV-2. PASS
analyses of all ten phytocomponents using Lipinski's Rule of five showed promising results. Druglikeness and toxicity assessment exhibited the feasibility of phytocomponents as drug candidates with no predicted toxicity. Molecular dynamics simulation study
of NRBD of SARS-CoV-2 nucleocapsid protein-alpha-spinasterol complex and PL-(PRO)-cycloeucalenol complex displayed strong stability at 300 K. Both these complexes exhibited constant root mean square deviation (RMSDs) of protein side chains and Cα atoms throughout
the simulation run time. PL-(PRO) and NRBD are key proteins in viral replication, host cell immune evasion and viral assembly. |
|
|
Song, Eric, Bartley, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
We examined immune parameters in CSF and blood samples from a cohort of patients with COVID-19 and significant neurological
complications. We found divergent immunological responses in the CNS compartment, including increased levels of IL-12 and IL-12-associated innate and adaptive immune cell activation. We found increased proportions of B cells in the CSF relative to the periphery
and evidence of clonal expansion of CSF B cells, suggesting a divergent intrathecal humoral response to SARS-CoV-2. All COVID-19 cases examined had anti-SARS-CoV-2 IgG antibodies in the CSF whose target epitopes diverged from serum antibodies. We directly
examined whether CSF resident antibodies target self-antigens and found a significant burden of CNS autoimmunity, with the CSF from most patients recognizing neural self-antigens. We produced a panel of monoclonal antibodies from patients CSF and show that
these target both anti-viral and anti-neural antigens, including one mAb specific for the spike protein that also recognizes neural tissue. This exploratory immune survey reveals evidence of a compartmentalized and self-reactive immune response in the CNS
meriting a more systematic evaluation of neurologically impaired COVID-19 patients. |
|
|
Evaluation of eosinopenia as a diagnostic and prognostic indicator in COVID-19 infection |
Soni, M |
Int J Lab Hematol |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study evaluated the role of eosinopenia as a diagnostic and prognostic indicator in COVID-19 infection. Information
on 429 patients with confirmed COVID-19, admitted to Apollo Hospitals, Chennai, India between 04 June 2020 to 15 August 2020, was retrospectively collected. 79.25% of the patients included in the study had eosinopenia on admission. The median eosinophil count
in COVID-19-positive patients was 0.015 × 10(9) /L, and in negative patients, it was 0.249 × 10(9) /L. Eighteen per cent of the positive patients presented with 0 eosinophil count. Eosinopenia for early diagnosis of COVID-19 had a sensitivity of 80.68% and
specificity of 100% with an accuracy of 85.24. Role of eosinopenia in prognostication of COVID-19 was found to be insignificant. There was no statistically significant difference between the median eosinophil counts in survivors and nonsurvivors. |
|
Predicting SARS-CoV-2 Weather-Induced Seasonal Virulence from Atmospheric Air Enthalpy |
Spena, A, Palombi, et al |
Int J Environ Res Public Health |
Epidemiology| Épidémiologie |
The present study involves a detailed investigation based on the first 20-30 days of the epidemic before public health
interventions in 30 selected Italian provinces with rather different climates. A correlating equation between the incidence rate at the early stage of the epidemic and the foregoing average specific enthalpy of atmospheric air was developed, and an enthalpy-based
seasonal virulence risk scale was proposed to predict the potential danger of COVID-19 outbreak due to the persistence of weather conditions favorable to SARS-CoV-2 viability. As an early detection tool, an unambiguous risk chart expressed in terms of coupled
temperatures and relative humidity (RH) values was provided, showing that safer conditions occur in the case of higher RHs at the highest temperatures, and of lower RHs at the lowest temperatures. Despite the complex determinism and dynamics of the pandemic
and the related caveats, the restriction of the study to its early stage allowed the proposed risk scale to result in agreement with the available infectivity data highlighted in the literature for a number of cities around the world. |
|
The Seroprevalence of SARS-CoV-2 Antibody in the
Asymptomatic Population |
Stout, RobertL, Rigatti, et al |
medRxiv |
Epidemiology| Épidémiologie Immunology | Immunologie |
The seroprevalence of COVID-19 in the self-reported well US population is currently unknown. In September we tested
a convenience sample of 63,106 life insurance applicants for COVID-19 and found a prevalence of 6.6%. This population was specifically selected because they were not being evaluated clinically but solely being tested for mortality risk. Using 2019 US census
estimates this equals more than 11.1 million (bootstrap 95% CI: 10.8 – 11.5 million) asymptomatically infected patients, which is double the number of cases reported to CDC as of September 1st. |
|
Stubbs, ChrisW, Springer, et al |
medRxiv |
Epidemiology| Épidémiologie |
In fall 2020 we analyzed the COVID-19 infection rate among undergraduate students at 9 colleges and Universities in
the greater Boston area and 4 comparison schools elsewhere. The cumulative infection rate shows no correlation with the total number of students on campus, t.he fractional occupancy of dormitories, or remote instruction vs. hybrid instruction. These data
are consistent with a hypothesis of students predominantly acquiring infection off-campus, with little community transmission within dormitory housing. |
|
|
Subbarayan, K, Ulagappan, et al |
Curr Cancer Drug Targets |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study was conducted to get insights into the enhanced frequency of COVID-19 infection in lung adenocarcinoma (LUAD).
Using different bioinformatics tools, the expression and methylation patterns of ACE2 and TMPRSS2 were analyzed in healthy and malignant tissues.An age dependent increase in ACE2 was observed in LUAD tissue and was inversely correlated to methylation of the
promoter. TMPRSS2 was downregulated in LUAD of smokers. |
|
|
Summer, Sabrina, Schmidt, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Our aim was to explore the reliability of minimal transport media, comprising saline and the CDC recommended Viral
Transport Media (HBSS VTM), for the diagnosis of SARS-CoV-2 and other respiratory viruses (influenza A, respiratory syncytial virus, adenovirus, rhinovirus and human metapneumovirus) compared to commercial products, such as the Universal Transport Media (UTM).
Proper detection of clinical specimens even after long-time storage at high temperatures, independent of the transport medium's composition was observed |
|
|
Szabo, Balint Gergely, Lenart, et al |
medRxiv |
Therapeutics| Thérapeutique |
A single-center, prospective, observational, sequential cohort study was performed among consecutive adults hospitalized
with PCR-confirmed COVID-19 between March-July,202. The effectiveness of the antiviral favipiravir was assesssed. In this study, favipiravir did not seem to affect disease progression. |
|
|
Tadesse, AW, Tarekegn, et al |
J Interpers Violence |
Public Health response| Interventions de santé publique |
This study conducted to assess the magnitude of intimate partner violence (IPV) against women during the lock-downs
in Ethiopia.. 11.0%, 20.0%, and 13.8% of women experienced physical, psychological, and sexual IPVs respectively. The prevalence of IPV among married women was comparable to the national pre-COVID figure of IPV. |
|
|
Waitlisted Transplant Candidates' Attitudes and Concerns Toward Transplantation
During COVID-19 |
Tan, EK, Koh, et al |
Ann Transplant |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
We conducted a standardized phone survey of patients awaiting organ transplant (SOT) and hematopoietic stem cell transplant
(HSCT) to assess the prevalence of inadequate health literacy and attitudes toward transplant during the COVID-19 pandemic. Regardless of health literacy, most waitlisted candidates recognized that the current pandemic is a serious situation affecting their
care and that COVID-19 poses a significant risk to their health. Despite the increased risks, most patients reported they would choose immediate transplantation if there was no foreseeable end to the pandemic, and especially if the medical urgency did not
permit further delay. |
|
Tekcan Sanli, DE, Yildirim, et al |
Diagn Interv Radiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we aimed to reveal the relationship between initial lung parenchymal involvement patterns and the subsequent
need for hospitalization and/or intensive care unit admission in coronavirus disease 2019 (COVID-19) positive cases. Chest CT findings at first admission were evaluated. In case of infiltration dominated by right middle or upper lobe involvement with a consolidation
pattern, there is a higher risk of future intensive care need. Also, the need for intensive care increases as the number of affected lobes and percentage of affected parenchymal involvement increase. |
|
|
Thielecke, Marlene, Theuring, et al |
medRxiv |
Epidemiology| Épidémiologie Transmission |
This study examines the possibility that kindergartens represent reservoirs of infection. Against a backdrop of increased
pandemic activity in the community, this cross-sectional study does not suggest that kindergartens are silent transmission reservoirs. |
|
|
Comparable specimen collection from both ends
of at-home mid-turbinate swabs |
Truong, Melissa, Pfau, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Across two studies that included unsupervised at-home mid-turbinate specimen collection for SARS-CoV-2 testing, ~1%
of participants used the wrong end of the swab. We found that molecular detection of respiratory pathogens and a human biomarker were comparable between specimens collected from the handle of the swab and those collected correctly. Older participants were
more likely to use the swab backwards. |
|
Vaira, LA, Hopkins, et al |
Rhinology |
Long-Term Sequelae |
|
Multicentre randomised case-control study that involved 18 patients with COVID-19 related anosmia or severe hyposmia
for more than 30 days. Nine patients were prescribed systemic prednisone and nasal irrigation with betamethasone, ambroxol and rinazine for 15 days. The other 9, untreated, patients were used as controls. The olfactory function was evaluated with CCCRC test
at 20 and 40 days from the first evaluation. In the control group, a median olfactory score of 20 (IQR 30) was detected at baseline. At the 20-day control there was no significant improvement in olfactory function. The improvement in olfactory performance
became significant at the 40-day follow-up compared to baseline scores 60 (IQR 60) versus 20 (IQR 30)]. In the treatment group, patients had a mean olfactory score of 10 (IQR 15) at initial control. At the 20-day control, a significant im-provement in the
olfactory scores, compared to the baseline, was detected 70 (IQR 40) versus 10 (IQR 15)]. Olfactory function further improved at 40 days median score 90 (IQR 50)]. |
|
|
Walker, GregoryJ, Naing, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
We assessed whether neutralising antibody titres for SARS-CoV-2 correlated with signal cut-off ratios in five commercially
available enzyme immunoassays (EIAs), and one in-house assay based on expressed spike protein targets. Sera from individuals recovered from patients or convalescent plasma donors who reported laboratory-confirmed SARS-CoV-2 infection (n=200), and negative
control sera collected prior to the COVID-19 pandemic (n=100) were assessed in parallel. Neutralising antibodies were detected in 166 (83%) samples. Compared with this, the most sensitive EIAs were the Cobas Elecsys Anti-SARS-CoV-2 (98%) and Vitros Immunodiagnostic
Anti-SARS-CoV-2 (100%), which detect total antibody targeting the N and S1 antigens, respectively. The assay with the best quantitative relationship with microneutralisation was the Euroimmun IgG. These results suggest the marker used (total Ab vs IgG vs IgA),
and the target antigen are important determinants of assay performance. |
|
|
Wang, F, Ran, et al |
Blood Purif |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We retrospectively recruited consecutive adult COVID-19 patients who were diagnosed with ARDS according to Berlin definition
from 13 designated intensive care units in the city of Wuhan, China. Potential risk factors of acute kidney injury (AKI) as well as the relation between AKI and in-hospital mortality were investigated. A total of 275 COVID-19 patients with ARDS were included
in the study, and 49.5% of them developed AKI during their hospital stay. In comparison with patients without AKI, patients who developed AKI were older, tended to have chronic kidney disease, had higher Sepsis-Related Organ Failure Assessment score on day
1, and were more likely to receive invasive ventilation and develop acute organ dysfunction. Importantly, increasing AKI severity was associated with increased in-hospital mortality when adjusted for other potential variables. |
|
|
Wang, M, Nie, et al |
J Paediatr Child Health |
Epidemiology| Épidémiologie |
This study aimed to identify the epidemiological characteristics and transmission dynamics of paediatric cases. Information
on 1369 paediatric cases with COVID-19 from 8 December 2019 to 7 March 2020 in Hubei province was extracted from the National Infectious Disease Surveillance System. Among 1369 paediatric cases, the median age was 9 years and 58.2% of them were males. The
proportion of severe and critical cases in children was lower than that in adults and the proportion of asymptomatic cases in children was five times greater than for adult cases. The epidemiological curve of paediatric cases lagged behind that of adults by
19 days, and the first spike of the epidemic curve in senior high school students occurred 1 week earlier than in other paediatric groups. The proportion of clustered cases among children was about twice that for adults. |
|
|
The Effect of COVID-19 Residential Lockdown on Subjective Well-Being in China |
Wang, Y, Wu, et al |
J Med Internet Res |
Mental Health |
|
This study aims to explore the effect of the residential lockdown on subjective well-being (SWB) of individuals during
COVID-19. The sample consisted of 1,790 lockdown residents (73.18% female) and 3,580 non-lockdown residents (gender matched with 1,790 lockdown residents) on Sina Weibo. The time (before the residential lockdown, after the residential lockdown) × area (lockdown,
non-lockdown) interactions in integral analysis (N = 5370) showed that after the residential lockdown, compared with non-lockdown group, the lockdown group scored lower in some negative SWB indicators, including somatization (F(1, 5368) = 13.593, P .05) while
those in developed areas changed. The more negative changes in residents' SWB in developed areas imply greater demand of psychological intervention under residential lockdown. |
|
Wen, J, Suo, et al |
Eur J Dermatol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Abstract and full text not available. |
|
|
COVID-19 worries and mental health: the moderating effect of age |
Wilson, JM, Lee, et al |
Aging Ment Health |
Mental Health |
|
848 adults ranging in age from 19=8 to 85 filled in on online survey assessing anxiety, depression, mental status,
and perceived risks regarding COVID-19. Older age associated with better mental health. In younger age groups, there was a significant association between anxiety and perceived likelihood of contracting COVID-19. This was not oberserved in older ages (50+) |
|
Wolf, TG, Zeyer, et al |
Int J Environ Res Public Health |
Healthcare Response | Réponse des soins de santé |
This study queried over 1000 Swiss dentists on COVID-19 awareness, precautions perception, and personal COVID-19 experience.
A very small percentage (0.91%) reported having either symptoms or a positive test themselves. Only 6,7% reduced their practice activity to less that 10% of normal. |
|
|
COVID-19-Associated Fusobacterium nucleatum Bacteremia, Belgium |
Wolff, L, Martiny, et al |
Emerg Infect Dis |
Clinical data| Données cliniques |
We report 4 cases of Fusobacterium nucleatum bacteremia associated with coronavirus disease (COVID-19). Three cases
occurred concomitantly with COVID-19 diagnosis; 1 occurred on day 15 of intensive care. None of the patients had known risk factors for F. nucleatum bacteremia. F. nucleatum infection could represent a possible complication of COVID-19. |
|
Yang, Shaomin, Zhou, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Novel circular RNA's were identified among the Betacoronavirus genus of Coronaviridae, SARS-CoV-2, SARS-CoV and MERS-CoV
in in-vitro infection models. This suggests circRNAs may be an important component of the coronavirus transcriptome. |
|
|
Collateral damage during the attention for COVID-19 pandemic |
Abdo-Francis, J, Bosques-Padilla, et al |
Cirugia y cirujanos |
Review Literature| Revue de littérature |
|
|
Abdullahi, L, Onyango, et al |
PLoS One |
Review Literature| Revue de littérature |
SR: PubMed, Google Scholar, World Health Organization (WHO), MEDRXIV and Google were searched from their inception
until May 30, 2020 for up-to-date published and grey resources. PubMed, Google Scholar, World Health Organization (WHO), MEDRXIV and Google from their inception until May 30, 2020 for up-to-date published and grey resources.
|
|
|
Dental Care Access and the Elderly: What Is the Role of Teledentistry? A Systematic Review |
Aquilanti, L, Santarelli, et al |
Int J Environ Res Public Health |
Review Literature| Revue de littérature |
SR: major electronic databases for studies published in English until 30 June 2020: the PubMed, Cochrane Library,
Web of Science, Scopus, and CINAHL databases. |
|
Investigating the Psychological Impact of COVID-19 among Healthcare Workers: A Meta-Analysis |
Batra, K, Singh, et al |
Int J Environ Res Public Health |
Review Literature| Revue de littérature |
MA: bibliographical databases, including Medline, Embase, CINAHL, PsycINFO, and Scopus were searched. The pooled prevalence
of anxiety, depression, stress, post-traumatic stress syndrome, insomnia, psychological distress, and burnout was 34.4%, 31.8%, 40.3%, 11.4%, 27.8%, 46.1%, and 37.4% respectively |
|
Hemodynamic and mechanical ventilation approach in patients with COVID-19 |
Carrillo-Esper, R, Mejía-Gómez, et al |
Cirugia y cirujanos |
Review Literature| Revue de littérature |
|
|
Biosensors for the Detection of Bacterial and Viral Clinical Pathogens |
Castillo-Henríquez, L, Brenes-Acuña, et al |
Sensors (Basel) |
Review Literature| Revue de littérature |
|
|
Cutaneous Manifestations in Confirmed COVID-19 Patients: A Systematic Review |
Conforti, C, Dianzani, et al |
Biology (Basel) |
Review Literature| Revue de littérature |
SR: A positive PCR determination of SARS-COV-2 from conjunctival swabs suggest that eye discharge can also be contagious.
These cutaneous manifestations may aid in identifying otherwise asymptomatic COVID-19 carriers in some cases or predict a more severe evolution in others. |
|
da Silva Brandão, E, Mandelbaum, et al |
Journal of wound care |
Review Literature| Revue de littérature |
|
|
|
Silver-Based Nanomaterials as Therapeutic Agents Against Coronaviruses: A Review |
Das, C, Paul, et al |
International journal of nanomedicine |
Review Literature| Revue de littérature |
|
|
Eiche, T, Kuster, et al |
Int J Environ Res Public Health |
Review Literature| Revue de littérature |
|
|
|
The impact of the COVID-19 epidemic on the content of the delusions |
Girasek, H, Gazdag, et al |
Psychiatria Hungarica : A Magyar Pszichiatriai Tarsasag tudomanyos folyoirata |
Review Literature| Revue de littérature |
|
|
Battle for supremacy: nucleic acid interactions between viruses and cells |
Hennessy, EJ, FitzGerald, et al |
J Clin Invest |
Review Literature| Revue de littérature |
|
|
Kuno, G |
Viruses |
Review Literature| Revue de littérature |
|
|
|
Łukaszuk, E, Stenzel, et al |
Pathogens |
Review Literature| Revue de littérature |
|
|
|
The Contribution of Endothelial Dysfunction in Systemic Injury Subsequent to SARS-Cov-2 Infection |
Maiuolo, J, Mollace, et al |
Int J Mol Sci |
Review Literature| Revue de littérature |
|
|
Characterising long-term covid-19: a rapid living systematic review |
Michelen, Melina, Manoharan, et al |
medRxiv |
Review Literature| Revue de littérature |
SR: Medline and CINAHL (EBSCO), Global Health (Ovid), WHO Global Research Database on covid-19, LitCOVID, and Google
Scholar were searched up to 28th September 2020. Our findings suggest that long covid is a complex, heterogeneous condition; however, the limited evidence base currently precludes a precise definition of its symptoms and prevalence. There is a clear need for
robust, controlled, prospective cohort studies, including different at-risk populations and settings, incorporating appropriate investigations, collected and recorded in a standardised way. |
|
Multisystem inflammatory syndrome in children and SARS-CoV-2: A scoping review |
Panigrahy, N, Policarpio, et al |
Journal of pediatric rehabilitation medicine |
Review Literature| Revue de littérature |
ScR: PubMed and Scopus were searched from December 31st, 2019 to Oct 5th, 2020. MIS-C can be a unique and potentially
life-threatening manifestation of SARS-CoV-2 in children and often requires medical intervention. |
|
Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications |
Rahban, M, Habibi-Rezaei, et al |
Antioxidants (Basel) |
Review Literature| Revue de littérature |
|
|
Sabbah, DA, Hajjo, et al |
Curr Top Med Chem |
Review Literature| Revue de littérature |
|
|
|
First Line of Defense in COVID-19: Masks in Clinical Practice |
Singh, T, Ichhpujani, et al |
Asia Pac J Public Health |
Review Literature| Revue de littérature |
|
|
Sulimov, VB, Kutov, et al |
Curr Top Med Chem |
Review Literature| Revue de littérature |
|
|
|
Alexandre, J, Cracowski, et al |
Fundam Clin Pharmacol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Beaton, A, Zühlke, et al |
European heart journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Society of behavioral medicine statement on COVID-19 and rural health |
Behrman, P, Fitzgibbon, et al |
Transl Behav Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bielecki, M, Patel, et al |
Travel Med Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Awareness of Human Factors in the operating theatres during the COVID-19 pandemic |
Britton, CR, Hayman, et al |
J Perioper Pract |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bryant, C |
J Exp Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Butler, SM |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Carrillo-Esper, R, Melgar-Bieberach, et al |
Cirugia y cirujanos |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chiauzzi, E, Clayton, et al |
JMIR Ment Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Underlying Principles of a Covid-19 Behavioral Vaccine for a Sustainable Cultural Change |
Couto, KC, Moura Lorenzo, et al |
Int J Environ Res Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Davidson, I |
J Virol Methods |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 and the need for disability conscious medical education, training, and practice |
Doebrich, A, Quirici, et al |
Journal of pediatric rehabilitation medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Editors, Plos One |
PloS one |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ekstein, D, Noyman, et al |
The Israel Medical Association journal : IMAJ |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Elkbuli, A, Baroutjian, et al |
Am Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Feng, X, Chen, et al |
Anesthesiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ferreira, ALCG, Correa, et al |
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The role of schools and school-aged children in SARS-CoV-2 transmission |
Flasche, Stefan, Edmunds, et al |
The Lancet Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gao, F, Tao, et al |
Biopreserv Biobank |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Gonah, L |
Annals of global health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Grant, WB, Lahore, et al |
Nutrients |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Green, Damian, Filkin, et al |
The Lancet Healthy Longevity |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hall, E, Kreuter, et al |
J Contin Educ Health Prof |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Efforts at COVID-19 Vaccine Development: Challenges and Successes |
Haque, A, Pant, et al |
Vaccines (Basel) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hoagwood, KE, Purtle, et al |
The American Psychologist |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hufsky, F, Beerenwinkel, et al |
Viruses |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A Lesson From the COVID-19 Pandemic: Preparing Future Health Care Professionals |
Ince, J, Minhas, et al |
The Journal of emergency medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Jager, MJ, Seddon, et al |
Asia Pac J Ophthalmol (Phila) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Exploring the link between risk perception in Internet media and COVID-19 prevalence in Europe |
Jarynowski, A, Wójta-Kempa, et al |
Int J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Jena, NR |
Phys Chem Chem Phys |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Diagnosis and Management of Acute Respiratory Distress Syndrome in a Time of COVID-19 |
Kassirian, S, Taneja, et al |
Diagnostics (Basel) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 and nuclear cardiology: Introducing the "forward" virtual visit |
Kaushik, A, Patel, et al |
J Card Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kennedy, AP, Yam, et al |
PLoS One |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Increased ambient noise and elevated vocal effort contribute to airborne transmission of COVID-19 |
Kopechek, JA |
The Journal of the Acoustical Society of America |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kuehn, BM |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kwee, RM, Adams, et al |
Radiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
La Rosée, P, Bremer, et al |
Med Klin Intensivmed Notfmed |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Mackie, SarahL, Brouwer, et al |
The Lancet Rheumatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
CT characteristics of COVID-19: reversed halo sign or target sign? |
Marchiori, E, Nobre, et al |
Diagn Interv Radiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
McGregor, MJ, Harrington, et al |
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Race, Power, and COVID-19: A Call for Advocacy within Bioethics |
Mithani, Z, Cooper, et al |
Am J Bioeth |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Molina, LT |
Faraday Discuss |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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COVID-19 (SARS-CoV-2) recommendations for surgical procedures. Leadership towards elective surgery |
Morales-Morales, C, González-Urquijo, et al |
Cirugia y cirujanos |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nisha, Mehru, Naim, et al |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
"The Tip of the Iceberg": Commentary on Sports, Health Inequity, and Trauma Exacerbated by COVID-19 |
Noel-London, K, Grimsley, et al |
J Athl Train |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Özdemir, Hİ, Savaş, et al |
Diagn Interv Radiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Parker, M, Spennemann, et al |
Journal of the Acoustical Society of America |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Pennell, NA, Dillmon, et al |
J Clin Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Why Do We Still Lack a COVID-19 Vaccine? Searching for the Missing Pieces |
Perosa, F, Favoino, et al |
Endocr Metab Immune Disord Drug Targets |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Radujkovic, A, Merle, et al |
Nutrients |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rosenthal, JA, Awan, et al |
Ann Allergy Asthma Immunol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Best Practices for Encouraging Student Participation in Both Face-to-Face and Virtual Environments |
Rothstein, A, Harr, et al |
Journal of allied health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ruiz Estrada, Mario Arturo |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Russell, E, Agua-Doce, et al |
Cytometry Part A |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
AAID White Paper: Guidance for Implant Practices During the COVID-19 Pandemic |
Rutkowski, JL |
The Journal of oral implantology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sattui, SE, Graef, et al |
Expert Rev Clin Immunol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chest Radiography in COVID-19: No Role in Asymptomatic and Oligosymptomatic Disease |
Schaefer-Prokop, C, Prokop, et al |
Radiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Shankar, EM, Che, et al |
Pathog Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shen, M, Xiao, et al |
Ann Allergy Asthma Immunol |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Shevel, E |
The Israel Medical Association journal : IMAJ |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mortalité, congé et arythmie chez les patients ayant la COVID-19 et une atteinte
cardiaque |
Si, D, Du, et al |
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Singh, Jerome Amir, Upshur, et al |
The Lancet Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Prevention and control measures for SARS-CoV-2 (COVID-19) in surgery |
Sosa-Hernández, Ó, Andrade-Bautista, et al |
Cirugia y cirujanos |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Maximizing Participant and Staff Safety During Assessment of Physical Function in the COVID-19 Era |
Storer, TW, Latham, et al |
J Am Geriatr Soc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
RSNA International Trends: A Global Perspective on the COVID-19 Pandemic and Radiology in Late
2020 |
Tan, BS, Dunnick, et al |
Radiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Dermatological surgery during the COVID-19 pandemic: experience of a large academic center |
Tee, MW, Stewart, et al |
J Am Acad Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Todorovic, M, Coyne, et al |
Med Teach |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Van Wicklin, SA |
Plastic Surgical Nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Varble, N, Blain, et al |
Eur Radiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Vest, JR, Blackburn, et al |
Public Health Rep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yang, Yue, Baik, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Time to R(t) < 1 for COVID-19 public health lockdown measures |
Yung, CF, Saffari, et al |
Epidemiol Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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Ear Nose Throat J |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
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Plastic Surgical Nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses |
Commentary/Editorial| Commentaire/Éditorial |
|
Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.*
Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.
Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers.
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Séquelles à long terme:
Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.
Santé mentale:
Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées
à la pandémie.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives