Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-12-08

Good afternoon,

There are 1201 citations in today’s scan. 637 were considered primary research or review literature.

Highlights today include:

CANADA

· Guardado et al. described the development and optimization of a direct method for extracting SARS-CoV-2 RNA from municipal wastewater using magnetic beads. Using this optimized magnetic bead-based extraction protocol, the presence of SARS-CoV-2 RNA was verified in wastewater collected from sewershed locations in Atlantic Canada.

· Maharaj et al. investigated the role of non-SARS-CoV-2 respiratory virus test positivity on COVID-19 two independent syndromic surveillance systems (self reported COVID-like illbness and emergency department visits) in Ontario, Canada. There were strong positive correlations of both COVID-like illness (CLI) and emergency department (ED) visits for upper respiratory causes with COVID-19 cases up to and including a rise in entero/rhinovirus. There was a strong negative correlation of both CLI and ED visits for upper respiratory causes with COVID-19 cases during a fall in entero/rhinovirus.

· McCarthy et al.  analyze the COVID-19 epidemic in Ontario, Canada. They quantified the age- and setting (household, workplace, community, and school)-specific mixing patterns and their evolution during the escalation of public health interventions in Ontario, Canada.  They estimated a reduction in the average individual contact rate from 12.27 to 6.58 contacts per day, with an increase in household contacts, following the implementation of control measures. They also estimated increasing trends by age in both the susceptibility to infection by SARS-CoV-2 and the proportion of symptomatic individuals diagnosed.

PUBLIC HEALTH INTERVENTION

· Plumper et al follow European countries as they struggled through the first wave of the SARS-CoV-2 pandemic. We analyze when countries were confronted with the virus, how long it took until the number of new infections peaked and at what level of infections that peak was achieved via social distancing and lockdown policies. We find that countries in which the virus made significant landfall later in time enjoyed a latecomer advantage that some of these countries squandered, however, by not responding quickly enough and that an early lockdown was more effective than a hard lockdown.

TRANSMISSION

· Lin et al conducted an outbreak investigation where 9 cases of COVID-19 were found in a building where all cases lived in three vertically aligned units sharing the same piping system. No close contacts between the index cases and other families indicated that the transmission might not occur through droplet and close contacts. Airflow detection and simulation experiment revealed that flushing the toilets could increase the speed of airflow in the pipes and transmitted the airflow from Apartment 15-b to 25-b and 27-b. Reduced exhaust flow rates in the infected building might have contributed to the outbreak.

EPIDEMIOLOGY

· Krastinova et al  investigated infection rates, clinical characteristics, occupational exposure and household transmission among all symptomatic HCWs between 17 March and 20 April. The incidence rate of symptomatic SARS-CoV-2 was estimated to be 5% (110/2188). 35% of the 314 HCWs tested positive and 8% were hospitalised. Factors independently associated with positive RT-PCR were occupational profile with direct patient facing and presence of anosmia Transmission from HCWs to household members was reported in 9 (14%) cases, and 2 deaths occurred.

LONG-TERM SEQUELAE

· Smet et al assessed 220 patients after severe COVID-19. Fifty-four percent of patients had abnormal lung function 10 weeks after diagnosis. Restriction was the most prevalent pulmonary function, with the more critically ill patients being more prone to this condition. Yet, restriction could not be linked with abnormal imaging results or residual symptoms.

CLINICAL DATA

· Shi et al., examine CT images of 3389 COVID-19 patients, 1593 community-acquired pneumonia (CAP) patients, and 1707 nonpneumonia subjects were included to explore the different patterns of lung and lung infection. The analysis found that COVID-19 patients have a significant reduced lung volume with increased density and mass, and the infections tend to present as bilateral lower lobes.

DIAGNOSTICS

· Grassin-Delyle et al., characterize exhaled breath from mechanically ventilated adults with COVID-19. They identified a characteristic breathprint for COVID-19. We could differentiate between COVID-19 and non-COVID-19 ARDS with accuracy of 93%. The four most prominent volatile compounds in COVID-19 patients were methylpent-2-enal, 2,4-octadiene 1-chloroheptane, and nonanal.

THERAPEUTICS

· Yoon et al compared the mortality and clinical outcome of patients with COVID-19 who received 200mL of convalescent plasma (CCP) with a Spike protein IgG titer within 72 hours of admission to propensity score-matched controls. There was no difference in mortality or oxygenation between CCP recipients and controls at day 28. When stratified by age, compared to matched controls, CCP recipients <65 years had 4-fold lower mortality and 4-fold lower deterioration in oxygenation or mortality at day 28. For CCP recipients, pre-transfusion Spike protein IgG, IgM and IgA titers were associated with mortality at day 28 in univariate analyses.

· Proud et al show that prophylactic intra-nasal administration of the TLR2/6 agonist INNA-051 in a SARS-CoV-2 ferret infection model effectively reduces levels of viral RNA in the nose and throat. After 5 days post-exposure to SARS-CoV-2, INNA-051 significantly reduced virus in throat swabs by up to a 24 fold (96% reduction) and in nasal wash up to a 15 fold (93% reduction) in comparison to untreated animals.

Regards,

Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley Otten, Drew Greydanus, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark, Catherine Card, Ruey Su, Paul McLaren

Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news

Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance, Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI, Réponse des soins de santé, Immunologie, économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux

PUBLICATIONS	AUTHORS / AUTEURS	SOURCE	FOCI / DOMAINE	SUMMARY / SOMMAIRE
Real-time polymerase chain reaction trends in COVID-19 patients	Abbas,  S,  Rafique, et al	Pakistan Journal of Medical Sciences	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	To assess trends of RT-PCR test in Coronavirus infected Patients. A total of three hundred and ninety-two patients with mild to moderate illness, PCR positive for COVID 19 were included study with age range 9-45 and mean 33.22±7.98 years. 2% patients were females and 98% males. The duration of the negative test result was Mean ± Std. Deviation 9.05±2.00 with 7 – 8 days 38.8% in and 11 – 12 days in 40.8%. PCR results on Day 7 and 8 were negative in 36.7% patients whereas positive in 63.3%. PCR results on Day 11 and 12 were negative in 79.6% patients whereas positive in 20.4%.  To conclude rT-PCR inclines to give false negative results additionally can stay positive in asymptomatic patients for moderately longer-term.
SARS-CoV-2 infection among asymptomatic healthcare workers of the emergency department in a tertiary care facility	Abdelmoniem,  R,  Fouad, et al	Journal of Clinical Virology	Epidemiology| Épidémiologie	This study aimed to detect SARS-CoV-2 infection among asymptomatic HCWs of the ED of a large tertiary center in Cairo, Egypt. Of the 203 HCWs, 14.3 % tested positive by RT-PCR. 18.2 % HCWs tested positive with RST: 20 with both IgM and IgG; 14 with IgM only, and 3 with IgG only. Age, gender, and/or occupation were not risk factors for SARS-CoV-2 infection. This illustrates the importance of screening all HCWs regardless of symptoms, and the need for strict measures in securing HCWs to reduce transmission from healthcare facilities to the community during the current pandemic.
Potential Use of Antigen-Based Rapid Test for SARS-CoV-2 in Respiratory Specimens in Low-Resource Settings in Egypt for Symptomatic Patients and High-Risk Contacts	Abdelrazik,  AM,  Elshafie, et al	Lab Med	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The lateral-flow immunochromatographic BIOCREDIT COVID-19 antigen test was evaluated using nasopharyngeal swabs in a viral transport medium from patients with confirmed infection, contacts, and exposed healthcare professionals at Fayoum University Hospital in Egypt. Three hundred ten specimens from 3 categories-patients with confirmed diagnoses of COVID-19, contacts, and exposed healthcare professionals-were included; 188 specimens were RT-PCR-positive, from which 81 were detected by rapid antigen test. Overall sensitivity was 43.1%. Sensitivity was significantly higher in specimens with high viral loads. Poor sensitivity of the BIOCREDIT COVID-19 test does not permit its use for diagnosis, and it can only be used in conjunction with RT-PCR for screening.
Adherence Of Facemask During COVID Pandemic Among South Asian Countries-An Observational Study	Abid,  Khadijah,  Imran, et al	Research Square prepub	Public Health response| Interventions de santé publique	To investigate the adherence rate of face masks among the people of South Asian countries namely Pakistan, Bangladesh, and India, and also to examine correlations between face mask adherence and socio-demographic factors. The mean age of the participants was 31.32±9.83 years. Out of all these participants, there were 826 (46.3%) males and 959 (53.7%) were females. Univariate analysis showed that females, Muslims, education level till graduate, employed, monthly income and Bangladeshi participants had higher odds of face mask adherence (p<0.05). The multivariate analysis showed that females, Muslims, urban residents, secondary level education, employed, monthly income $100 - $300, and Bangladeshi were strongly associated with face mask adherence (p<0.05).
Is COVID-19 really a life threatening pandemic - a survey on popular perception	Abinaya,  S,  Sekar, et al	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	A self-administered questionnaire completed by 100 people to gain the popular perception of the COVID-19 pandemic. The majority of the study population gave positive responses that COVID-19 is really a life-threatening pandemic. 100% of the population were aware of the pandemic, it's outbreaks in several countries and its devastating effects.
Fear of COVID-19 and Stigmatization toward Infected People among Jordanian People	Abuhammad,  S,  Alzoubi, et al	Int J Clin Pract	Public Health response| Interventions de santé publique	This study aims to explore the prevalence rates of stigma and fear among people in Jordan during COVID-19 pandemic and to assess socio-demographic and personal factors contributing to the prevalence rates of fear and stigma among people in Jordan during COVID-19 pandemic. The prevalence of fear among study participants was 52%. The prevalence of stigma toward infected people and their contact was 64%. The predictors of stigma toward infected people with COVID-19 and their contact were income, living area, and downloaded application to trace COVID-19 cases. Moreover, the predictors of fear were income living area and downloaded application to trace COVID-19 cases (P≤ .001).
COVID-19 and stroke in sub-Saharan Africa: Case series from Dar Es Salaam	Adebayo,  PB,  Kassam, et al	Pan African Medical Journal	Clinical data| Données cliniques	We present a case series of COVID -19 related stroke in 3 patients from Tanzania.
Angiotensin Converting Enzyme Inhibitors, A Risk Factor of Poor Outcome in Diabetic Patients with COVID-19 Infection	Aghaaliakbari,  F,  Abbasi, et al	Iran J Kidney Dis	Epidemiology| Épidémiologie Clinical data| Données cliniques	We investigated the adverse effect of ACEIs in 617 diabetic and nondiabetic patients with COVID-19. Mean ± SD age was 58.49 ± 15.80 (range: 18 to 94) years old. Cox regression analysis revealed that age (adjusted hazard ratio HR] = 1.04, 95% CI: 1.03 to 1.06), diabetes mellitus (adjusted HR = 2.07, 95% CI: 1.32 to 3.26), immunocompromised patients (adjusted HR = 2.33, 95% CI: 1.29 to 4.21), acute kidney injury (AKI) (adjusted HR = 3.23, 95% CI: 2.01 to 5.19), ICU admission (adjusted HR = 2.48, 95% CI: 1.46 to 4.21), Asthma and COPD (adjusted HR = 2.13, CI:1.6 to 4.28) and ACEI (adjusted HR = 3.08, 95% CI: 1.56 to 6.06), respectively were associated with in-hospital death. Among diabetic patients, ACEI (adjusted HR = 3.51, 95% CI: 1.59 to 7.75), AKI (adjusted HR = 3.32, 95% CI: 1.76 to 6.45) and ICU admission (adjusted HR = 3.64, 95% CI: 1.530 to 8.65) were associated with increased mortality. The Kaplan-Meier survival curve showed a lower survival rate in diabetic patients with ACE inhibitor (adjusted HR = 3.36, 95% CI: 2.25 to 7.71).
PMC7711254; The impact of COVID-19 pandemic on dental practice in Iran: a questionnaire-based report	Ahmadi,  H,  Ebrahimi, et al	BMC Oral Health	Healthcare Response | Réponse des soins de santé	In the present study, we aimed to evaluate the impact of COVID-19 pandemic on dental practice by conducting an online questionnaire among the Iranian dental practitioners and finding their perspectives on the subject.  The majority of the participants (n = 170, 70%) did not perform non-emergency procedures during the pandemic. However, most of the dentists (n = 210, 87%) had problems, providing personal protective equipment during the pandemic.
PMC7709596; A five day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness	Ahmed,  S,  Karim, et al	Int J Infect Dis	Therapeutics| Thérapeutique RCT	To determine the rapidity of viral clearance and safety of ivermectin among adult SARS-CoV-2 patients we conducted a randomized, double-blind, placebo-controlled trial of oral ivermectin alone (12 mg once daily for 5 days) or in combination with doxycycline (12 mg ivermectin single dose and 200 mg stat doxycycline day-1 followed by 100 mg 12hrly for next 4 days) compared with placebo among 72 hospitalized patients in Dhaka, Bangladesh. Clinical symptoms of fever, cough and sore throat were comparable among the three treatment arms. Virological clearance was earlier in the 5-day ivermectin treatment arm versus the placebo group (9.7 days vs. 12.7 days; P = 0.02); but not with the ivermectin + doxycycline arm (11.5 days; P = 0.27). There were no severe adverse drug events recorded in the study. A 5-day course of ivermectin was found to be safe and effective in treating mild COVID-19 adult patients.
While studies on covid-19 vaccine is ongoing; the public's thoughts and attitudes to the future Covid-19 vaccine	Akarsu,  B,  Canbay Özdemir, et al	Int J Clin Pract	Public Health response| Interventions de santé publique	In this study, we aim to investigate the thoughts and attitudes of individuals towards the future COVID-19 vaccine. This descriptive study was carried out on the web between 10/06/2020 - 10/07/2020. The sample constitutes all individuals above 18 years of age using social media and smartphone. Seven hundred fifty-nine were participated. 49.7% of the participants stated to be vaccinated; 38.4% of them stated to be vaccinated their children against COVID-19; if the vaccine for COVID-19 is developed. In our study afraid of the side effects of vaccine and not thinking it can be reliable as it will be a new vaccine is the most reasons of indecision and rejection about COVID 19 vaccine.
Knowledge, practice and emotional status related to COVID-19 pandemic among radiology technicians working at pandemic hospitals	Akyurt,  N	European Journal of Radiology	Mental Health | santé mentale Healthcare Response | Réponse des soins de santé	This study aimed to evaluate knowledge, attitude, practice and emotional and psychological concerns related to COVID-19 pandemic among radiology technicians working at pandemic hospitals across Turkey. A total of 228 radiology technicians working at pandemic hospitals across Turkey were included on a voluntary basis in this questionnaire-based online survey.  Our findings revealed association of female gender, co-morbid psychiatric disease, lack of training unawareness of safety and risk management plans, lack of experience in COVID-19 imaging and high workload with higher risk of poor emotional state and/or intense fear of the disease among radiology technicians during pandemic.
Seroprevalence of SARS-CoV-2 in migrant workers in Kuwait	Alali,  WQ,  Bastaki, et al	J Travel Med	Epidemiology| Épidémiologie Immunology | Immunologie	Low-skilled migrant workers (about fifth of Kuwait population) are vulnerable to SARS-CoV-2 due to their crowded living conditions. Prevalence of SARS-CoV-2 and seroprevalence was 21.0% and 38.1%, receptively among 525 migrant supermarket workers. Higher prevalence estimates are likely attributed to the workers' housing conditions where physical distancing opportunities are limited.
The effects of COVID-19 pandemic on pregnant women: Perceived stress, social support and sleep quality	Alan,  S,  Vurgec, et al	Yonago acta medica	Mental Health | santé mentale	This cross-sectional study aims to identify the relationship between perceived stress, social support and sleep quality and the effects of the COVID-19 pandemic on pregnant women’s perceived stress, social support and sleep quality. After the sample calculation was performed, the study involved 166 participants. The data, which were quantitative in nature, were collected through a web-based, online questionnaire administered within a determined period. Of all the participating pregnant women, 88% reported to have poor sleep quality during the COVID-19 pandemic. A moderate, negative relationship was found between the Pittsburgh Sleep Quality Index and the Multidimensional Scale of Perceived Social Support and a weak, positive relationship with the Perceived Stress Scale. While statistically significant differences were found between the pregnant women’s perceived stress according to their psychological perceptions and perceptions about daily life (P < 0.05), no significant differences were found between the perceived social support level and sleep quality index.
“Fast deep learning computer-aided diagnosis of COVID-19 based on digital chest x-ray images”	Al-antari,  M,  Hua, et al	Applied Intelligence	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In this paper, a simultaneous deep learning computer-aided diagnosis (CAD) system based on the YOLO predictor is proposed that can detect and diagnose COVID-19, differentiating it from eight other respiratory diseases: atelectasis, infiltration, pneumothorax, masses, effusion, pneumonia, cardiomegaly, and nodules. The CAD system presented in this paper can make a prediction at the rate of 108 frames/s (FPS), which is close to real-time. The proposed deep learning CAD system can reliably differentiate COVID-19 from other respiratory diseases.
An Assessment of Distress Levels of Patients Undergoing Lung Cancer Treatment and Surveillance During the COVID-19 Pandemic	Albano,  D,  Feraca, et al	Journal for Nurse Practitioners	Mental Health | santé mentale	The purpose of this quality improvement initiative was to identify anxious/distressed lung cancer patients and address their mental health needs directly related to the COVID-19. A total of 441 patients were screened utilizing a national distress thermometer. 47% were counseled by the NP, 32% sent for referral to the social worker. Patients reported reasons for distress as fear of delaying testing, contracting the virus and changes in their lifestyle. We found that screening all patients during the pandemic, yielded a higher than normal percentage of patients who were in need of some level of mental health services. © Elsevier Inc.
Field evaluation of a rapid antigen test (Panbio™ COVID-19 Ag Rapid Test Device) for COVID-19 diagnosis in primary healthcare centres	Albert,  E,  Torres, et al	Clinical Microbiology and Infection	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	We evaluated the Panbio™ COVID-19 Ag Rapid Test Device for diagnosis of coronavirus 2019 disease (COVID-19) in symptomatic patients (n = 412) attending primary healthcare centres. Out of 412 patients, 43 (10.4%) tested positive by RT-PCR and RAD, and 358 (86.9%) tested negative by both methods; discordant results (RT-PCR+/RAD–) were obtained in 11 patients (2.7%). Overall specificity and sensitivity of rapid antigen detection (RAD) was 100% (95%CI 98.7–100%) and 79.6% (95%CI 67.0–88.8%), respectively, taking RT-PCR as the reference. Overall RAD negative predictive value for an estimated prevalence of 5% and 10% was 99% (95%CI 97.4–99.6%) and 97.9% (95%CI 95.9–98.9), respectively. SARS-CoV-2 could not be cultured from specimens yielding RT-PCR+/RAD– results (n = 11).
Predictors of illness severity in COVID-19 cases	AlDossary,  ReemA,  Alnimr, et al	Research Square prepub	Epidemiology| Épidémiologie	This is an observational study to describe the clinical and epidemiological features of 341 COVID-19 cases in the Eastern Province of Saudi Arabia over the first three months from reporting the first case in the country and identify factors associated with severity of the illness. The median age was 45 years and males were twice as affected as females (p value  65 years), Bengali ethnicity, and in patient with com-morbidities including diabetes, hypertension, and dyslipidemia (p-value = 0.001). Furthermore, case fatality rate was found to be 10% and was significantly higher in male gender compared to female (13.8%vs 2.6%), and in Asian ethnicity (17.9%) compared to Arabs (6%) and African counterparts (0) (p-value = 0.002). No association was found between viral load represented by the RT-PCR cycle threshold (Ct) values and severity of illness.
Multivocality of Saudi COVID-19 discourse in social media posts: A socio-semiotic multimodal perspective	Al-Ghamdi,  N,  Albawardi, et al	GEMA Online Journal of Language Studies	Public Health response| Interventions de santé publique	This paper examines the discourse of COVID-19 (also known as coronavirus) in social media posts and argues that the mediated COVID-19 discourse in Saudi Arabia enacted a variety of voices and thematic discourses that cannot be fully evaluated without reference to the locality of the sociolinguistic semiotics of the speech community. It attempts to construct the various non-verbal multivocalities in written and visual COVID-19 discourse present in 24 texts obtained from Saudi social media platforms, namely WhatsApp and Twitter, during the COVID-19 pandemic in the months of February, March and April, 2020.
Diabetes and Covid-19 among hospitalized patients in Saudi Arabia: a single-centre retrospective study	Alguwaihes,  AM,  Al-Sofiani, et al	Cardiovasc Diabetol	Epidemiology| Épidémiologie Clinical data| Données cliniques	The medical records of hospitalized adults with confirmed Covid-19 RT-PCR positive in Riyadh, Saudi Arabia from May to July 2020 were analyzed. The most prevalent comorbidities were vitamin D deficiency (74.7%), DM (68.3%), hypertension (42.6%) and obesity (42.2%). While diabetes mellitus (DM) patients have a a significantly higher death rate (20.5% versus 12.3%; p = 0.04) than their non-DM counterparts, other factors appear to be more significant predictors of fatal outcome.
Public Perceptions about Pharmacists' Role in Prescribing, Providing Education and Delivering Medications during COVID-19 Pandemic Era	Alhamad,  H,  Abu-Farha, et al	Int J Clin Pract	Public Health response| Interventions de santé publique	Data was collected from 578 participants who agreed to fill an  online questionnaire.  This study indicates that the public positively endorsed the impact of the educational role of the pharmacist, medication delivery services, and extending pharmacist prescribing authority during COVID 19 pandemic.
Semi-quantitative CT imaging in improving visualization of faint ground glass opacities seen in early/mild coronavirus (covid-19) cases	Ali,  RMM,  Ghonimy, et al	Egyptian Journal of Radiology and Nuclear Medicine	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	From first of May to July 15, 2020, 30 patients in Cairo, Egypt who have positive RT-PCR tests and positive pulmonary manifestation were included in our study. The combined use of visual and color coded images enhance and improve the early detection of faint ground glass opacities seen in early COVID-19 affection.
Psychosocial impact of lockdown among students	Ali,  SJ,  Jayaraj, et al	European Journal of Molecular and Clinical Medicine	Mental Health | santé mentale	A questionnaire consisted of 31 questions divided into three parts and was shared to students using online survey platform. 57% of the students felt anxious that their studies are affected during this lockdown. Most of the students are showing some symptoms of depression.
Emergent Ophthalmic Surgical Care at a Tertiary Referral Center During the COVID-19 Pandemic	Al-khersan,  H,  Kalavar, et al	American Journal of Ophthalmology	Healthcare Response | Réponse des soins de santé	This study characterized the delivery of emergent ophthalmic surgical care during April 2020 of COVID-19 pandemic compared with the same interval the previous year. The COVID-19 pandemic decreased our institution's surgical volume in April 2020 to approximately 10% of the usual volume. The pandemic changed the type of cases performed and led to a statistically significant decrease in both the age of our surgeons and patients relative to the same interval in the previous year.
Hyperglycemic Hyperosmolar State (HHS) with New-onset Diabetes Mellitus in a Patient with SARS CoV-2 Infection	Al-Naami,  Awaji,  Khan, et al	Research Square prepub	Clinical data| Données cliniques	New-onset DM or unmasking existing one, with or without metabolic complications, has been reported in SARS CoV-2 infection. New-onset DM in association with HHS alone or combination with DKA is uncommon but a possible manifestation of SARS CoV-2 infection that poses management challenges where the outcome may be worst.
Stroke care during the COVID-19 outbreak in Spain: the experience of Spanish stroke units	Alonso de Leciñana,  M,  Castellanos, et al	Stroke Vasc Neurol	Healthcare Response | Réponse des soins de santé	This study analyses the impact on stroke care of reorganising the healthcare system in response to the first COVID-19 outbreak peak in Spain and the strategies adopted by Spanish stroke units to deal with this impact. There was an overall reduction in admissions for all stroke types during the outbreak's peak and in the number of stroke code activations and intravenous thrombolysis treatments, results that were independent of the COVID-19 incidence rate. Participants reported a delay in workflow metrics and a reduction of admissions to stroke units, outpatient clinics and rehabilitation therapies.
The prevalence of asymptomatic and symptomatic COVID-19 in a cohort of quarantined subjects	Al-Qahtani,  M,  AlAli, et al	International Journal of Infectious Diseases	Epidemiology| Épidémiologie Clinical data| Données cliniques	Asymptomatic SARS-CoV-2 infection development and progression was investigated in subjects undergoing mandatory quarantine on airport arrival. Results: 188/2714 (6.9%) patients became SARS-CoV-2 positive. On arrival, 136/188 tested positive, with 44/188 (23.4%) symptomatic and 92/188 (48.9%) asymptomatic. Of the 52/188 (27.7%) testing negative on arrival, 27/52 subsequently became positive and developed symptoms 2–13 days after arrival. 25/188 (13.3%) remained asymptomatic and tested positive at day 14
Investigating the Use of Social Media in Supporting Children with Cognitive Disabilities and Their Caregivers from Saudi Arabia	Alshenaifi,  R,  N, et al		Healthcare Response | Réponse des soins de santé	This study investigates the use of social media in supporting and empowering Saudi caregivers of children with cognitive disabilities. Through interviews with 13 caregivers, we examined the motivations and concerns around using social media in relation to their children or students' conditions. We also investigated the role of social media during the COVID-19 pandemic. We found that caregivers used social media with caution to seek information and emotional support, to spread awareness, and to communicate and build communities. Our findings also suggest that caregivers face a great deal of challenges in security and privacy, social stigma and negative discussions, misinformation, and lack of resources. © 2020 Owner/Author.
Management of gynecological cancers in the COVID-19 era: a survey from Turkey	Altın,  D,  Yalçın, et al	J Turk Ger Gynecol Assoc	Healthcare Response | Réponse des soins de santé	This study aimed to investigate how gynecologic oncologists modified their patient management during COVID-19 in Turkey. Most Turkish gynecologic oncologists modified their management of gynecologic cancers due to the COVID-19 pandemic. While chemotherapy was preferred for ovarian cancer, postponement of the surgery, with or without non-surgical options, was considered for early stage, low-grade endometrial cancer. Treatment of gynecologic cancers should be decided on a case by case basis, taking into account local COVID-19 infection rates and availability of health facilities.
Modelling the Test, Trace and Quarantine Strategy to Control the COVID-19 Epidemic in the State of Sao Paulo, Brazil	Amaku,  Marcos,  Covas, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique Economics | Économie	In this paper we modelled and simulated a test-trace-and-quarantine strategy to control the COVID-19 outbreak in the State of Sao Paulo, Brasil. Indiscriminately testing the entire population of Sao Paulo reaching more than 40 million people at a maximum cost of 2.25 billion USD, that would reduce the total number of cases by the end of 2020 by 90%. The second strategy investigated testing only symptomatic cases and their immediate contacts – this strategy reached a maximum cost of 150 million USD but also reduced the number of cases by 90%.
PMC7709599; Low-dose Whole-lung Irradiation for COVID-19 Pneumonia: Final Results of a Pilot Study	Ameri,  A,  Ameri, et al	Int J Radiat Oncol Biol Phys	Therapeutics| Thérapeutique	Five, 1, and 4 patients received single 0.5Gy, two 0.5Gy, and single 1.0Gy LD-WLI, respectively. The mean improvement in SpO2 at days 1 and 2 after RT was 2.4% (±4.8%) and 3.6% (±6.1%), respectively, with improvement in 9 patients after 1 day.
COVID-19 pandemic and psychosocial problems in children and adolescents in vellore-district	Anbarasu,  A,  Bhuvaneswari, et al	European Journal of Molecular and Clinical Medicine	Mental Health | santé mentale	A total of 124 male adolescents participated in the study. Through in-depth interview it was found that majority of the urban adolescents suffered with fear, worry, stress, anxiety, depression, lack of coping skills and poor mental health. Other hand, the respondents from rural part did not suffer with any severe mental health problems.
Knowledge, Attitude, and Behavior of Indonesian Society towards Covid-19 Pandemic	Anggraeni,  R,  Mahdiani, et al	Systematic Reviews in Pharmacy	Public Health response| Interventions de santé publique	This study aimed to determine the knowledge, attitude, and behavior of Indonesian society to the Covid-19 pandemic. The knowledge, attitude, and behavior of Indonesian respondents towards the Covid-19 pandemic were good.
THE impact of COVID-19 on work force in information technology sector	Anjani,  PK,  Sundram, et al	European Journal of Molecular and Clinical Medicine	Mental Health | santé mentale	This study identified the existence of positive correlation between the work satisfaction and the psychological health. This study also identified that existence of positive correlation between the Family-work conflict and the psychological stress.
Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2	Arba,  M,  Wahyudi, et al	Computers in biology and medicine	Therapeutics| Thérapeutique	This study aims to find out the binding dynamics of active Remdesivir-triphosphate (RDV-TP) to RNA-dependent RNA polymerase (RdRp) by means of molecular dynamics (MD) simulation. 500 ns MD simulations revealed that the interactions of protein and template-primer RNA were dominated by salt bridge interactions with phosphate groups of RNA.
CovidRisk: An evidence-based online COVID-19 risk calculator	Artzrouni,  Marc	medRxiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	We propose an online app (bit.ly/2KQKNmd) which calculates the risks of COVID-19 infection for a person coming into contact with a group of individuals characterized by a specified prevalence rate.  For a well-documented September 2020 White House event the app predicts that with an assumed 3% prevalence rate one’s risk of infection was almost 5 % and seven of the 150 guests would become infected - as actually happened.
Experimental visualization of sneezing and efficacy of face masks and shields	Arumuru,  V,  Pasa, et al	Physics of Fluids	Transmission Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)	Tracer particles are introduced in the flow to capture the emulated turbulent jet formed due to a sneeze. The visualization is accomplished using a camera and laser illumination. This highlights that the present widely accepted safe distance of 6 ft is highly underestimated. We strongly recommend using at least a three-layer homemade mask with a social distancing of 6 ft to combat the transmission of COVID-19 virus.
Exploring Perceived Stress among Students in Turkey during the COVID-19 Pandemic	Aslan,  I,  Ochnik, et al	Int J Environ Res Public Health	Mental Health | santé mentale	The aim of this study was to reveal the prevalence of perceived stress and mental health among 358 Turkish students during the pandemic and to explore predictors of stress levels. Anxiety and physical inactivity significantly predicted high perceived stress.
CNN-based transfer learning–BiLSTM network: A novel approach for COVID-19 infection detection	Aslan,  MF,  Unlersen, et al	Applied Soft Computing	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In this study, two deep learning architectures have been proposed that automatically detect positive COVID-19 cases using Chest CT X-ray images. While the COVID-19 classification accuracy of the first architecture is 98.14%, this value is 98.70% in the second hybrid architecture.
Detection of SARS-CoV-2 in follicular and endocervical fluid of IVF candidates with positive PCR tests	Ataei,  M,  Sadeghitabar, et al	European Journal of Molecular and Clinical Medicine	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	This study aimed to evaluate the presence of SARS-CoV-2 in follicular and endocervical fluid in COVID-19 patients receiving ART treatments for emergent IVF. The nasopharynx test for COVID-19 was conducted for all ART patients 48 hours before the day of the oocyte trigger. At the time of oocyte trigger, cervicovaginal fluid and the first aspirated follicular fluid were tested for SARS-CoV-2. SARS-CoV-2 was not detected in the follicular or endocervical fluid of the women with positive nasopharynx PCR tests.
Soldiering on only goes so far: How a qualitative study on Veteran loneliness in New Zealand influenced that support during COVID-19 lockdown	Austin,  G,  Calvert, et al	Journal of Military, Veteran and Family Health	Mental Health | santé mentale	This study performed a qualitative survey regarding veteran loneliness during government imposed pandemic lockdowns in New Zealand. Respondents to an earlier survey were identified as lonely or non-lonely, and purposeful sampling aimed to enrol 10 in each category. Ten of the 20 potential participants responded: 6 lonely and 4 non-lonely. Social and geographic isolation, problems with re-integration into the civilian community, and health problems were found to contribute to Veteran loneliness. Social connectedness, particularly to service peers, was the primary mitigating factor, which was exacerbated by the pandemic.
PMC7715648; StackNet-DenVIS: a multi-layer perceptron stacked ensembling approach for COVID-19 detection using X-ray images	Autee,  P,  Bagwe, et al	Phys Eng Sci Med	Modelling/ prediction| Modélisation/prédiction Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	This study developed an algorithm to look for visible irregularities found in chest X-rays as a tool for identification of COVID-19 disease. This research presents an approach to create a classifier model named StackNet-DenVIS which is designed to act as a screening process before conducting the existing swab tests. A dataset gathered from multiple reliable sources consisting of 9953 Chest X-rays (868 Covid and 9085 Non-Covid) was used. The accuracy, sensitivity, and specificity obtained on our proposed model were 95.07%, 99.40% and 94.61% respectively.
The Relation Between Otolaryngology-Specific Symptoms and Computed Tomography Findings in Ambulatory Care COVID-19 Patients	Avcı,  H,  Karabulut, et al	Ear Nose Throat J	Clinical data| Données cliniques	This study aimed evaluate the relation between otolaryngology-specific symptoms and computed tomography findings in ambulatory care COVID-19 patients. The study was conducted with medical records of 987 (82%) patients with confirmed COVID-19. Patients were divided into 2 groups as computed tomography (CT)-negative and CT-positive groups considering the presence of the CT findings depicting COVID-19 disease. Advanced age, cough, and shortness of breath could be related to CT scan positivity.
Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis	Avendaño-Ortiz,  J,  Lozano-Rodríguez, et al	Heliyon	Immunology | Immunologie	Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins.
COVID-CLNet: COVID-19 Detection with Compressive Deep Learning Approaches	Awedat,  Khalfalla,  Essa, et al	arXiv	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	To assist in identifying COVID-19 cases in the shortest possible time, we propose a computer-aided detection (CADe) system that uses the computed tomography (CT) scan images. Experiments performed on different compressed methods show promising results for COVID-19 detection. In addition, our novel weighted method based on different sensing matrices that used to capture boosted features demonstrates an improvement in the performance of the proposed method. [PREPRINT]
Amotosalen and ultraviolet A light treatment efficiently inactivates severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human plasma	Azhar,  EI,  Hindawi, et al	Vox Sang	Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)	SARS-CoV-2 RNA has been detected in plasma and platelet products from asymptomatic blood donors, raising concerns about potential risks associated with transfusion and therapeutics utilizing plasma from convalescent donors. Amotosalen/UVA light treatment of SARS-CoV-2 spiked human plasma units efficiently and completely inactivated >3·32 ± 0·2 log of SARS-CoV-2 infectivity, showing that such treatment could minimize the risk of transfusion-related SARS-CoV-2 transmission.
Understanding the spatio-temporal pattern of COVID-19 outbreak in India using GIS and India's response in managing the pandemic	Bag,  R,  Ghosh, et al	Regional Science Policy and Practice	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	The present study has explored the spatio-temporal pattern of Coronavirus spread in India including spatial clustering, identification of hotspot, spatial heterogeneity, and homogeneity, spatial trend, and direction of COVID-19 cases using spatial statistical analysis during the period of 30 January to 20 June 2020.
PMC7708801; The potential of Paritaprevir and Emetine as inhibitors of SARS-CoV-2 RdRp	Bahadur Gurung,  A,  Ajmal Ali, et al	Saudi J Biol Sci	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	.In the present study, a set of FDA approved antiviral drugs and antiviral phytocompounds were screened for their ability to bind within the SARS-CoV-2)RNA-dependent RNA polymerase (RdRp) enzyme active pocket. The top 3 hits among the FDA approved drugs were Paritaprevir (D33), Rilpivirine (D19) and Simeprevir (D31). Emetine (P5), 7,4-di-O-galloyltricetifavan (P28) and Oleanolic acid (P17) were the top three phytocompounds hits.
Mathematical modeling of COVID-19: Impact of non-pharmaceutical interventions in India	Bajiya,  VP,  Bugalia, et al	Chaos	Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de sant&amp;eacute; publique	In the present study, we propose a compartmental epidemic model incorporating quarantine and isolation compartments to (i) describe the current transmission patterns of COVID-19 in India, (ii) assess the impact of currently implemented NPIs, and (iii) predict the future course of the pandemic with various scenarios of NPIs in India. Our result shows that the implementation of an almost perfect isolation in India and 33.33% increment in contact-tracing on June 26, 2020 may reduce the number of cumulative confirmed cases of COVID-19 in India by around 53.8%.
Dentists’ knowledge, attitudes, and professional behavior toward the COVID-19 pandemic: A multisite survey of dentists’ perspectives	Bakaeen,  LG,  Masri, et al	Journal of the American Dental Association	Healthcare Response | Réponse des soins de santé	A questionnaire was circulated via e-mail and social media platforms to dentists in North America, Europe, Eastern Mediterranean, and Western Pacific regions. It covered demographic characteristics and questions about the COVID-19 outbreak related to dentists’ levels of comfort for preventive and safety measures, provision of treatment, affect on work, and financial implications. The respondents reported a lack of preparedness to confront a highly infectious respiratory disease. A new level of protective armamentarium in the dental operatory and updated operational guidance and policies are required.
Psychological wellbeing during the lockdown in Italy: A multicenter study project in the age of COVID-19	Balsamo,  M,  Carlucci, et al	Psicoterapia Cognitiva e Comportamentale	Mental Health | santé mentale	The purposes of this research project is to assess the dimensions of psychological wellbeing in the general population during the Italian national lockdown and the potential factors that contribute to, or mitigate, these effects. [ITALIAN]
Linear behavior in Covid19 epidemic as an effect of lockdown	Bambusi,  D,  Ponno, et al	Journal of Mathematics in Industry	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	We propose a mechanism explaining the approximately linear growth of Covid19 world total cases as well as the slow linear decrease of the daily new cases (and daily deaths) observed (in average) in USA and Italy.
Germany's next shutdown-Possible scenarios and outcomes	Barbarossa,  MV,  Fuhrmann, et al	Influenza Other Respir Viruses	Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de sant&amp;eacute; publique	With the rapid increase of reported COVID-19 cases, German policymakers announced a 4-week "shutdown light" starting on November 2, 2020. Applying mathematical models, possible scenarios for the evolution of the outbreak in Germany are simulated. The results indicate that independent of the effectiveness of the current restrictive measures they might not be sufficient to mitigate the outbreak. Repeated shutdown periods or permanently applied measures over the winter could be successful alternatives.
PMC7694560; Impacts of different operational temperatures and organic loads in anaerobic co-digestion of food waste and sewage sludge on the fate of SARS-CoV-2	Bardi,  MJ,  Oliaee, et al	Process Saf Environ Prot	Coronavirology| Coronavirologie	The impacts of different operational temperatures, and organic load (OL) on the fate of SARS-CoV-2 during the anaerobic co-digestion of food waste (FW) and sewage sludge (SS) was evaluated.
Haemodynamic impact of positive end-expiratory pressure in SARS-CoV-2 acute respiratory distress syndrome: oxygenation versus oxygen delivery	Barthélémy,  R,  Beaucoté, et al	British journal of anaesthesia	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	This single-centre retrospective study aimed to evaluate the haemodynamic impact of PEEP increase in COVID-19 ARDS and its consequences on DaO2. We showed that higher PEEP was associated with an increase in Pao2/FiO2 ratio without improvement in oxygen delivery because of a decrease in cardiac output. When haemodynamic status and oxygen delivery were considered, most patients did not benefit from higher PEEP (>10 cm H2O).
A cross-national study of factors associated with perinatal mental health and wellbeing during the COVID-19 pandemic	Basu,  Archana,  Kim, et al	medRxiv	Mental Health | santé mentale	This international study sought to identify and measure the associations between pandemic-related information seeking, worries, and prevention behaviors on perinatal mental health during the COVID-19 pandemic. Clinically significant posttraumatic stress, anxiety/depression, and loneliness are highly prevalent in pregnant and postpartum women across 64 countries during the COVID-19 pandemic. Excessive information seeking and worries related to children and medical care are associated with clinically significant symptoms, whereas engaging in hygiene-related preventive measures were not.
Covid-19 Infection Induced Neuromyelitis Optica - A Case Report	Batum,  M,  Kisabay Ak, et al	Int J Neurosci	Clinical data| Données cliniques	In this case report, a patient infected with Covid 19 and diagnosed as neuromyelitis optica (NMO) with anamnesis, clinical and radiological findings is presented. This is the first case of parainfectious NMO considered to be induced by SARS-CoV-2.
ABO-RH blood group and risk of covid-19 in a moroccan population	Belaouni,  Mourad,  Malki, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim of this study was to reveal a possible association between the ABO-RH system and the risk of COVID-19 in the Moroccan population. The proportion of blood group A in patients with COVID-19 was significantly higher than in people in the comparison group (P = 0.007), while the proportion of blood group O in patients with COVID-19 was significantly lower than in people in the control group (P = 0.017). Comparison of the Rh blood groups of the two groups did not find a significant association (P = 0.608). [PREPRINT]
Supervised Image Classification Algorithm Using Representative Spatial Texture Features: Application to COVID-19 Diagnosis Using CT Images	Belkhatir,  Zehor,  Estepar, et al	medRxiv	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	We assessed the performance of the proposed classification pipeline in diagnosing the corona virus disease 2019 (COVID-19) from computed tomographic (CT) images.
Three COVID-19 cases with a long-term viral shedding period in Tunisia	Bennasrallah,  C,  Bannour, et al	Pan African Medical Journal	Clinical data| Données cliniques Long-Term Sequelae | séquelles à long terme	We report 3 cases (2 imported cases and 1 local case) with documented viral shedding (based on reverse transcription-polymerase chain reaction (RT-PCR) testing) of SARS-CoV-2 for 55, 59 and 63 days.
Ecg changes in a patient with covid-19 treated with hydroxychloroquine and azithromycin	Benouna,  ME,  Ech-Chenbouli, et al	Pan African Medical Journal	Clinical data| Données cliniques	This case report details treatment and outcomes of a 73-year old patient admitted to our hospital with moderate COVID-19 infection detected during acute coronary syndrome.
PMC7709594; Spatiotemporal ecological study of COVID-19 mortality in the city of São Paulo, Brazil: Shifting of the high mortality risk from areas with the best to those with the worst socio-economic conditions	Bermudi,  PMM,  Lorenz, et al	Travel Med Infect Dis	Epidemiology| Épidémiologie	This study aimed to analyse COVID-19 mortality in a spatiotemporal context in São Paulo, with respect to socio-economic levels. Our results corroborated the relationship between COVID-19 mortality and socio-economic conditions, revealing the importance of geographic screening in the integration of better actions to face the pandemic.
One-Enzyme Reverse Transcription qPCR Using Taq DNA Polymerase	Bhadra,  S,  Maranhao, et al	Biochemistry	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Taq DNA polymerase, one of the first thermostable DNA polymerases to be discovered, has been typecast as a DNA-dependent DNA polymerase commonly employed for PCR. However, Taq polymerase belongs to the same DNA polymerase superfamily as the Molony murine leukemia virus reverse transcriptase and has in the past been shown to possess reverse transcriptase activity. We report optimized buffer and salt compositions that promote the reverse transcriptase activity of Taq DNA polymerase and thereby allow it to be used as the sole enzyme in TaqMan RT-qPCRs. We demonstrate the utility of Taq-alone RT-qPCRs by executing CDC SARS-CoV-2 N1, N2, and N3 TaqMan RT-qPCR assays that could detect as few as 2 copies/μL of input viral genomic RNA.
Autopsy of COVID-19 patients in China	Bian,  XW,  Yao, et al	National Science Review	Clinical data| Données cliniques	This paper describes COVID-19  patient autopsy performed in compliance with the relevant Chinese laws. The pathological characteristics of pulmonary lesions caused by SARS-CoV-2 infection were similar to those from SARS infection but differences have been noticed. The post-mortem disclosed visible damage in the lungs and immune organs of COVID-19 patients.
COVID-19 pneumonia in patients with chronic myocarditis (hbv-associated with infarct-like debute): specifics of the diseases course, the role of the basic therapy (Part II)	Blagova,  OV,  Varionchik, et al	Rational Pharmacotherapy in Cardiology	Clinical data| Données cliniques	This report presents a description of a 35-year-old female patient with chronic infectious-immune myocarditis (morphologically confirmed, with a history of infarction-like onset and thromboembolic complications), who had continuous immunosuppressive therapy with methylprednisolone and mycophenolate mofetil. The patient also received new oral anticoagulants and tenofovir (for chronic HBV infection). COVID-19 (SARS-Cov-2 RNA+) was diagnosed in May 2020. Risk factors for the adverse course of coronavirus infection included severe obesity, heart failure, and life-threatening ventricular arrhythmias.
IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) with digital drug development	Blasiak,  A,  Lim, et al	Bioengineering and Translational Medicine	Therapeutics| Thérapeutique	The authors used IDentif.AI, a platform that pairs experimental validation with artificial intelligence (AI) and digital drug development to rapidly pinpoint unpredictable drug interactions and optimize infectious disease combination therapy design with clinically relevant dosages. IDentif.AI was paired with a 12-drug candidate therapy set representing over 530,000 drug combinations against the SARS-CoV-2 live virus collected from a patient sample.  IDentif.AI pinpointed the optimal combination as remdesivir, ritonavir, and lopinavir, which was experimentally validated to mediate a 6.5-fold enhanced efficacy over remdesivir alone. Additionally, it showed hydroxychloroquine and azithromycin to be relatively ineffective. IDentif.AI independently mirrored clinical trial outcomes to date without any data from these trials. The robustness of this digital drug development approach paired with in vitro experimentation and AI-driven optimization suggests that IDentif.AI may be clinically actionable toward current and future outbreaks
Effectiveness of non-pharmaceutical interventions on COVID-19 transmission in 190 countries from 23 January to 13 April 2020	Bo,  Y,  Guo, et al	International Journal of Infectious Diseases	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	This study evaluated and compared the effectiveness of four types of non-pharmaceutical interventions (NPIs) to contain the time-varying effective reproduction number (Rt) of coronavirus disease-2019 (COVID-19). The implementations of mandatory mask, quarantine, distancing and traffic were associated with changes (95% confidence interval, CI) of −15.14% (from −21.79% to −7.93%), −11.40% (from −13.66% to −9.07%), −42.94% (from −44.24% to −41.60%) and −9.26% (from −11.46% to −7.01%) in the Rt of COVID-19 when compared with those without the implementation of the corresponding measures. Distancing and the simultaneous implementation of two or more types of NPIs seemed to be associated with a greater decrease in the Rt of COVID-19.
Fractional optimal control dynamics of coronavirus model with Mittag–Leffler law	Bonyah,  E,  Sagoe, et al	Ecological Complexity	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	In this study, a fractional optimal control model is formulated in Atangana-Baleanu-Caputo derivative sense. The reproduction number and steady state of disease free of the Coronavirus model are examined and found to be globally stable. The existence and uniqueness of solution of the fractional Coronavirus model is established by using the Banach fixed point theorem approach. Three controls are considered in the model and Pontryagins Maximum Principle is used to establish the necessary conditions for optimal control solution. The numerical solution suggests that the best strategy is found to be the utilization of all three controls at the same time.
Unusual association of COVID-19, pulmonary tuberculosis and human immunodeficiency virus, having progressed favorably under treatment with chloroquine and rifampin	Bouaré,  F,  Laghmari, et al	Pan African Medical Journal	Clinical data| Données cliniques	This report presents the case of a 32-year-old patient who presented with mutiple infections and who did well under treatment with chloroquine and anti-mycobacterial drugs. This patient arrived at the ER with respiratory discomfort that had been evolving over a month with symptoms of flu and deterioration of her general condition. A chest CT scan revealed an aspect of lung miliary tuberculosis with isolation of Koch's bacilli in the sputum. A polymerization chain reaction (PCR) was positive for COVID-19 on a nasopharyngeal swab. HIV serology was positive. The course was marked by a spectacular clinical improvement and two negative COVID-19 PCR controls at the end of treatment (at days 9 and 10). Anti-tubercular drugs (especially, rifampin) are powerful enzyme inducers that can reduce the effectiveness of chloroquine in our patient. This therapeutic success may be linked to the effect of anti-tubercular drugs against SARS ncov-2, especially rifampin, inhibiting the formation of messenger RNAs of SARS ncov-2 or to the synergistic effect of chloroquine and rifampin.
Spatial risk factors for Pillar 1 COVID-19 case counts and mortality in rural eastern England, UK	Brainard,  JuliiS,  Rushton, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	This study attempted to identify spatial risk factors to see which geographic areas have populations at greatest risk of acquiring severe disease. For each residence area (local super output area),  data on air quality, deprivation levels, care home bed capacity, age distribution, rurality, access to employment centres and population density were obtained. Excess case counts or excess deaths were both predicted by the percentage of population age 65 years, care home bed capacity and less rurality: older population and more urban areas saw excess cases. Greater deprivation did not correlate with excess case counts but was significantly linked to higher mortality rates after infection. Neither excess cases nor excess deaths were predicted by population density, travel time to local employment centres or air quality indicators. Only 66% of mortality could be explained by locally high case counts. The results show a clear link between greater deprivation and higher COVID-19 mortality that is separate from wider community prevalence and other spatial risk factors.
A person-centered approach in studying coronavirus pandemic response: The role of HEXACO-PI-R and PANAS dimensions	Branovački,  B,  Sadiković, et al	Personality and Individual Differences	Epidemiology| Épidémiologie Public Health response| Interventions de santé publique	This study explored reactions to the COVID-19 pandemic and their relationship with personality traits using a person-centered approach. Sample of 471 Serbian citizens was collected during the first 7 weeks of the pandemic. Cluster analysis revealed three clusters based on reactions to the pandemic: Adapted, Antagonized, and Passive. Adaptive type is characterized by stable emotional reactions and adherence to behavioral guidelines. Antagonized cluster is characterized by lowered adherence to behavioral guidelines, while Passive cluster is characterized by increased fear and boredom. Clusters differed significantly on HEXACO and PANAS traits.
Adaptation of the Cuban version of the Coronavirus Anxiety Scale	Broche-Pérez,  Y,  Fernández-Castillo, et al	Death Stud	Mental Health | santé mentale	This study explores the psychometric properties of the Cuban version of Coronavirus Anxiety Scale (CAS). The sample comprised 376 Cuban participants. Concurrent validity and reliability were examined. A confirmatory factor analysis was performed. The CAS showed excellent psychometric characteristics. The internal consistency was very good (α = 0.88). There was a positive correlation between the CAS and the FCV-19S and an inverse association between anxiety and self-perceived quality of health.
PMC7716287; Handwashing and disinfection precautions taken by U.S. adults to prevent coronavirus disease 2019, Spring 2020	Brown,  LG,  Hoover, et al	BMC Res Notes	Public Health response| Interventions de santé publique	This study assessed self-reported hygiene precautions taken by U.S. adults during spring 2020 to prevent COVID-19 disease and identified demographic characteristics associated with these hygiene precautions. Most respondents reported taking hygiene-related precautions to prevent COVID-19; more respondents reported handwashing (93%) than disinfecting surfaces (74%). Men, younger respondents, those with lower income and education levels, and respondents in self-rated poor health had lower reported rates of both handwashing and disinfecting surfaces. Communications about hygiene precautions for COVID-19 prevention may need to target sub-populations with the greatest gaps in hygiene-related practices.
A multiregional extension of the SIR model, with application to the COVID-19 spread in Italy	Brugnano,  L,  Iavernaro, et al	Mathematical Methods in the Applied Sciences	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	The paper presents a new forecast model that includes the class of undiagnosed infected people, and has a multiregion extension, to cope with the in-time and in-space heterogeneity of an epidemic. The model is applied to the SARS-CoV2 pandemic that, starting from the end of February 2020, began spreading along the Italian peninsula, by first attacking small communities in north regions, and then extending to the center and south of Italy, including the two main islands. It has proved to be a robust and reliable tool for the forecast of the total and active cases, which can be also used to simulate different scenarios. In particular, the model is able to address a number of issues, such as assessing the adoption of the lockdown in Italy, started from March 11, 2020; the estimate of the actual attack rate; and how to employ a rapid screening test campaign for containing the epidemic.
Changes in daily loneliness for German residents during the first four weeks of the COVID-19 pandemic	Buecker,  S,  Horstmann, et al	Social Science and Medicine	Mental Health | santé mentale	This study investigated loneliness systematically to allow for evidence-based decision making. Daily loneliness slightly increased during the first two weeks since implementing the pandemic-related measures and slightly decreased thereafter. With increasing age, daily loneliness increased more strongly over the four weeks. Moreover, daily loneliness increased more strongly for parents compared to people without children. Thus, despite some increases in loneliness in some individuals, there was no linear increase in loneliness in response to the first pandemic-related measures in the present sample.
Employee work status, mental health, substance use, and career turnover intentions: An examination of restaurant employees during COVID-19	Bufquin,  D,  Park, et al	International Journal of Hospitality Management	Mental Health | santé mentale Public Health response| Interventions de santé publique	This study aims examined the relationships between employees’ work status (working, furloughed, or laid-off), mental health (psychological well-being and psychological distress), substance use (drug and alcohol use), and career turnover intentions during the pandemic. Analyzing the responses of 585 restaurant employees using structural equation modelling (SEM), findings revealed that working employees experienced higher levels of psychological distress, drug and alcohol use than furloughed employees. Moreover, psychological distress increased drug and alcohol use, as well as career turnover intentions. Lastly, all employees, regardless of their mental health, increased their substance use and indicated a desire to seek future employment in alternate industries during the pandemic.
Casting the net wide: universal testing of emergency admissions for SARS-CoV-2 to prevent onward transmission	Burns,  K,  Foley, et al	Journal of Hospital Infection	Epidemiology| Épidémiologie Clinical data| Données cliniques Public health interventions*| Interventions de sant&amp;eacute; publique	This research describes the experience of SARS-CoV-2 universal admission testing (UAT) in non-COVID-19 pathway emergency admissions (June - September, 2020), to assess (i) the UAT detection rate and (ii) the impact on patient and staff contact tracing. SARS-CoV-2 RNA was newly detected from nine (0.26%) patients (June (N = 3), July (N = 0), August (N = 1) and to September 20th (N = 5)). Five were female and the mean age was 49.6 years. None became symptomatic. The most common presentation was an abdominal complaint (N = 5). Four (44%) were admitted under surgical specialties. The median length of stay (LOS) was five days (range: 1–28). There were 23 patient and 21 staff close contacts. Before June 1st, the mean number of contacts per case was 4.5 patients (range: 0–17) and 4.9 staff (range: 1–37), falling to 2.5 patients (range: 0–5; P = 0.061) and 2.3 staff (range: 0–6; P < 0.05), respectively, during the study period. All close contacts remained asymptomatic, with none having SARS-CoV-2 detected on follow-up testing.
The impact of COVID-19 pandemic on patients receiving orthodontic treatment: An online questionnaire cross-sectional study	Bustati,  N,  Rajeh, et al	Journal of the World Federation of Orthodontists	Healthcare Response | Réponse des soins de santé	This study assessed the challenges faced by patients receiving orthodontic treatment and their preferred solutions to overcoming these challenges during this pandemic.  A total of 388 responses were analyzed: mean age 20.4 ± 4 years, 75% (291) female, and 58% (226) received their treatment at a public clinic. Of all participants, 27.3% (106) were still unable to attend their appointments and 69% (244) stated that closing of the clinic was the main reason for missing their appointments. Depending on their type of appliance, the patients faced different problems and chose multiple ways to deal with them. Most participants had fixed appliances, 84% (327), and only 21% (64) of them stated that they had no problem compared with 39% (11) and 36% (8) for removable appliance and clear aligner groups, respectively.
Association between statin use and outcomes in patients with coronavirus disease 2019 (COVID-19): a nationwide cohort study	Butt,  JH,  Gerds, et al	BMJ Open	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study investigated the association between recent statin exposure and risk of severe COVID-19 infection and all-cause mortality in patients with COVID-19 in Denmark. The study population comprised 4842 patients with COVID-19 (median age 54 years (25th-75th percentile, 40-72), 47.1% men), of whom 843 (17.4%) redeemed a prescription of statins. Patients with statin exposure were more often men and had a greater prevalence of comorbidities. The median follow-up was 44 days. After adjustment for age, sex, ethnicity, socioeconomic status and comorbidities, statin exposure was not associated with a significantly different risk of mortality (HR 0.96 (95% CI 0.78 to 1.18); 30-day standardised absolute risk (SAR), 9.8% (8.7% to 11.0%) vs 9.5% (8.2% to 10.8%); SAR difference, -0.4% (-1.9% to 1.2%)), severe COVID-19 infection (HR 1.16 (95% CI 0.95 to 1.41); 30-day SAR, 13.0% (11.8% to 14.2%) vs 14.9% (12.8% to 17.1%); SAR difference, 1.9% (-0.7% to 4.5%)), and the composite outcome of all-cause mortality or severe COVID-19 infection (HR 1.05 (95% CI 0.89 to 1.23); 30-day SAR, 17.6% (16.4% to 18.8%) vs 18.2% (16.4% to 20.1%); SAR difference, 0.6% (-1.6% to 2.9%)). The results were consistent across subgroups of age, sex and presumed indication for statin therapy. Among patients with statin exposure, there was no difference between statin drug or treatment intensity with respect to outcomes.
COVID-19 in people living with HIV: A multicenter case-series study	Cabello,  A,  Zamarro, et al	International Journal of Infectious Diseases	Epidemiology| Épidémiologie Clinical data| Données cliniques	This observational study was conducted to examine how COVID-19 affects people living with HIV (PLHIV) in Madrid. Sixty-three patients with HIV infection and confirmed or suspected COVID-19 were analyzed. The median age was 46 years (IQR: 37–56 years), and 88.9% were men. The median duration of HIV infection was 10.8 years (IQR: 6.5–16.8 years), and 96.8% were on antiretroviral therapy. 84.1% had previous comorbidities. The most common symptoms were fever (66.1%), cough (66.1%) and dyspnea (46.8%). Pneumonia was found in 47.5%, 28.6% of patients had severe disease, and 32.3% were admitted to hospital. The ICU admission rate and the mortality rate were both 3.17%. A significant association was observed between age, arterial hypertension, overweight, and diabetes mellitus and the severity of COVID-19. No association was observed between HIV-related factors and the severity of COVID-19. The rate of COVID-19 in HIV-patients was 1.68%. Similar hospitalization (31.74% vs 32.57%) and ICU admission (3.17% vs 2%) rates were observed with non-HIV infected patients. A lower mortality rate during hospitalization (10% vs 21.37%) and a lower global mortality rate (3.17% vs 6.96%) were also observed.
Epidemic oscillations induced by social network control: the discontinuous case	Caccioli,  Fabio,  De Martino, et al	arXiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	This study explored the issue of  relaxed measures leading to new epidemic waves and infection cycles in compartmentalized epidemic models on graphs in presence of a feedback between the infection state of the population and the structure of its social network for the case of discontinuous control. Showed that in random graphs the effect of containment measures is simply captured by a renormalization of the effective infection rate that accounts for the change in the branching ratio of the network. In a simple setting, a piece-wise mean-field approximations can be used to derive analytical formulae for the number of epidemic waves and their length. A variant of the model with imperfect information is used to model data of the recent covid-19 epidemics in the Basque Country and Lombardy, wherethe extent of social network disruption during lock downs were estimated and characterized the dynamical attractors.
Covid-19 ICU remote-learning course (CIRLC): Rapid ICU remote training for frontline health professionals during the COVID-19 pandemic in the UK	Camilleri,  M,  Zhang, et al	Journal of the Intensive Care Society	Healthcare Response | Réponse des soins de santé	This paper reports on the COVID-19 ICU Remote-Learning Course (CIRLC) - a remote delivery course developed in response to the pandemic. This one-day course focused on the fundamentals of Intensive Care. An iterative cycle of improvement was used to update the course content weekly. A course confidence questionnaire with quantitative and qualitative questions was used to evaluate effectiveness. Data is reported as n (%), means (SD) and thematic analysis was used for the open questions. Results: 1,269 candidates from 171 organisations completed the course, with 99 volunteer trainers. 96% of respondents rated the course as very or extremely useful. 86% rated the online platform as excellent. Overall confidence improved from 2.7/5 to 3.9/5. Qualitative data showed that the course was pitched at the appropriate level, accessible and built clinicians confidence to work in intensive care.
Myocardium injury biomarkers predict prognosis of critically ill coronavirus disease 2019 (Covid-19) patients	Cao,  L,  Zhang, et al	Annals of Palliative Medicine	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study identified prognostic factors that would help determine therapeutic approaches.  Found that age, lymphocyte count, and total bilirubin concentration were an independent prognostic factor for critically ill COVID-19 patients. Of particular importance, observed a significant elevation of myocardium injury biomarkers, including CK-MB, high-sensitivity cardiac troponini I (hs-cTnI), and Mb, in the non-survivor group. These myocardium injury biomarkers appeared to correlate with the time of survival, and two multivariate models have suggested hs-cTnI was a novel prognostic factor with a sensitivity of 75.0% and a specificity of 84.9%.
Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein Suggests a Biophysical Basis for its Dual Functions	Carlson,  CR,  Asfaha, et al	Molecular cell	Coronavirology| Coronavirologie	This study shows that the N protein of SARS-CoV-2, together with viral RNA, forms biomolecular condensates. Unmodified N protein forms partially ordered gel-like condensates and discrete 15-nm particles based on multivalent RNA-protein and protein-protein interactions. Phosphorylation reduces these interactions, generating a more liquid-like droplet. We propose that distinct oligomeric states support the two functions of the N protein: unmodified protein forms a structured oligomer that is suited for nucleocapsid assembly, and phosphorylated protein forms a liquid-like compartment for viral genome processing.
Tracking the characteristics of economic growth vulnerability to covid-19: A preliminary analysis	Carrasco,  CA,  Tovar-García, et al	Revista de Economia Mundial	Economics | Économie	This article examines the economic vulnerability to COVID-19-measured as the change in GDP growth forecasts for 2020-and its determinants for a sample of 194 countries. Identified the characteristics of the external sector and macroeconomic policy stance that are associated with an increase in economic vulnerability during the pandemic.
Why we should be more careful using hydroxychloroquine in influenza season during COVID-19 pandemic?	Çelik,  HG,  Keske, et al	International Journal of Infectious Diseases	Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique	The aim of this study was to describe the QTc prolongation and related adverse cardiac events during the administration of hydroxychloroquine (HCQ) and its combinations for the treatment of coronavirus disease 2019 (COVID-19). Hospitalized patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who received HCQ and had initial and follow-up electrocardiograms performed between March 10 and May 30, 2020 were included. Critical QTc prolongation was detected in 12% of the patients. On multivariate analysis, diabetes mellitus (odds ratio 5.8, 95% confidence interval 1.11–30.32, p = 0.037) and the use of oseltamivir (odds ratio 5.3, 95% confidence interval 1.02–28, p = 0.047) were found to be associated with critical QTc prolongation. © 2020 The Author(s)
Ambient PM2.5 exposure and rapid spread of COVID-19 in the United States	Chakrabarty,  RK,  Beeler, et al	Science of the Total Environment	Epidemiology| Épidémiologie	This study established the association between long-term exposure to ambient PM2.5 in the United States (US) and COVID-19 basic reproduction ratio R0– a dimensionless epidemic measure of the rapidity of disease spread through a population. We inferred state-level R0 values using a state-of-the-art susceptible, exposed, infected, and recovered (SEIR) model initialized with COVID-19 epidemiological data corresponding to the period March 2–April 30. This period was characterized by a rapid surge in COVID-19 cases across the US states, implementation of strict social distancing measures, and a significant drop in outdoor air pollution. We find that an increase of 1 μg/m3 in PM2.5 levels below current national ambient air quality standards associates with an increase of 0.25 in R0 (95%CI: 0.048–0.447). A 10% increase in secondary inorganic composition, sulfate-nitrate-ammonium, in PM2.5 associates with ≈10% increase in R0 by 0.22 (95%CI: 0.083–0.352), and presence of black carbon (soot) in the ambient environment moderates this relationship.
Retrospective Study of Nail Telemedicine Visits During the COVID-19 Pandemic	Chang,  MJ,  Stewart, et al	Dermatol Ther	Healthcare Response | Réponse des soins de santé	This study analyzed characteristics of nail teledermatology visits and provided recommendations for virtual nail visits during the pandemic.
Comparing SARS-CoV-2 and influenza A(H1N1)pdm09-infected patients requiring ECMO – A single-centre, retrospective observational cohort experience	Charlton,  M,  Dashey, et al	Journal of Infection	Epidemiology| Épidémiologie Clinical data| Données cliniques	This editorial presents the study findings that described the clinical characteristics and outcomes of 34 patients presenting with severe COVID-19 pneumonitis who received respiratory ECMO support during the COVID-19 pandemic to one of the commissioned UK respiratory ECMO centres. Earlier speculation by some teams about the potential application of ECMO suggested that it may be useful in severe cases of COVID-19, though this would depend very much on case selection. This speculation has since been borne out by more recent reports on single, small and larger case series of patients with severe COVID-19, where the authors have been cautious about the potential benefits of ECMO in such patients, emphasising the limited capacity for this complex treatment.
What factors drive the satisfaction of citizens with governments’ responses to COVID-19?	Chen,  CWS,  Lee, et al	International Journal of Infectious Diseases	Public Health response| Interventions de santé publique	This research scrutinizes the important factors influencing the satisfaction of citizens concerning their governments’ responses to the COVID-19 pandemic based on an open-sourced survey of 14 countries. Our results show that people pay stronger attention to the results of their governments’ battle against COVID-19 (number of confirmed cases and deaths per million population) rather than to what policies they initiate. Health policy and economic support do influence the approval of any national response to COVID-19.
Case report: Nutrition therapy and side-effects monitoring in critically ill coronavirus disease 2019 patients	Chen,  H,  Xue, et al	Heart and Lung	Clinical data| Données cliniques	This study reported the nutrition therapy and side-effects monitoring as well as the adjustment of the nutrition therapy of 2 critical COVID-19 patients, to provide clinical evidence for nutrition therapy and prevention of the side effects.
Efficient Social Distancing for COVID-19: An Integration of Economic Health and Public Health	Chen,  Kexin,  Chen, et al	arXiv	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	This paper investigates an efficient social distancing policy to manage the integrated risk from economic health and public health issues for COVID-19 using a stochastic epidemic modeling with mobility controls. This paper takes advantage of the community mobility data to model the COVID-19 processes and infer the COVID-19 driven economic values from major market index price, which allow us to formulate the search of the efficient social distancing policy as a stochastic control problem. We propose to solve the problem with a deep-learning approach. By applying our framework to the US data, we empirically examine the efficiency of the US social distancing policy and offer recommendations generated from the algorithm.
The presumed influence of digital misinformation: examining US public’s support for governmental restrictions versus corrective action in the COVID-19 pandemic	Cheng,  Y,  Luo, et al	Online Information Review	Public Health response| Interventions de santé publique	Informed by the third-person effects (TPE) theory, this study aims to analyze restrictive versus corrective actions in response to the perceived TPE of misinformation on social media in the USA. Results indicated that individuals also perceived that others were more influenced by misinformation about COVID-19 than they were. Further, such a perceptual gap was associated with public support for governmental restrictions and corrective action.
The Utility of CHA(2)DS(2)-VASc Scores as a Risk Assessment Tool in Low-Risk In-Hospital Patients With Coronavirus Disease 2019 Infection	Chew,  NW,  Ngiam, et al	Am J Cardiol	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study showed that the CHA(2)DS(2)-VASc score could aid prognostication of mortality and a composite end-point of inpatient death or invasive ventilation across CHA(2)DS(2)-VASc tertiles in COVID-19 patients. The CHA(2)DS(2)-VASc score was utilized as a potential tool to identify at-risk COVID-19 individuals in a generally young, low-risk, asymptomatic, or mildly symptomatic cohort. The study demonstrated that CV2-3 and CV ≥4 groups displayed higher rates of mechanical ventilation, ICU admissions, and composite end-point, compared with the CV ≤1 group. However, did not see a trend for all-cause mortality due to the low-risk nature of the cohort with its overall mortality rate of 0.5%.
Comparison of antiviral effect for mild-to-moderate COVID-19 cases between lopinavir/ritonavir versus hydroxychloroquine: A nationwide propensity score-matched cohort study	Choi,  MJ,  Kang, et al	International Journal of Infectious Diseases	Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique	This study compared the antiviral effect of hydroxychloroquine (HCQ) and lopinavir/ritonavir (LPV/r) in patients with COVID-19.  Overall, 4197 patients with mild-to-moderate COVID-19 were included. Patients were categorized into three groups: LPV/r (n = 1268), HCQ (n = 801), and standard care without HCQ or LPV/r (controls, n = 2128). The median viral shedding duration was 23 (IQR 17–32), 23 (IQR 16–32), and 18 (IQR 12–25) days in the LPV/r, HCQ, and control groups, respectively. Even after PSM, the viral shedding duration was not significantly different between LPV/r and HCQ groups: 23 (IQR, 17–32) days versus 23 (IQR, 16–32) days. On multivariate analysis, old age, malignancy, steroid use, and concomitant pneumonia were statistically significant risk factors for prolonged viral shedding.
In silico identification of a potent arsenic based lead drug di-phenyl phenoxy roxarsone against SARS-CoV-2	Chowdhury,  T,  Dutta, et al	Journal of the Indian Chemical Society	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	This article tried to address the plausible in silico identification of a novel lead drug molecule against COVID-19. Nine different arsenic (As) based molecules, roxarsone derivatives were designed and optimized for computational analysis to determine its binding affinity against SARS-CoV-2. The screened molecules were docked blindly against RNA dependent RNA polymerase (RdRp) using molecular docking software iGEMDOCK v2.1. On the basis of idock score in their respective catalytic domain, di-phenyl phenoxy roxarsone identified as promising inhibitor against SARS-CoV-2 with binding free energy calculated as -86.8 kcal/mol. Site specific docking was also executed with target site, receptor binding domain (RDB) of spike glycoprotein of SARS-CoV-2 whose structure was computationally designed using Phyre2 server. The interaction study of RDB with di-phenyl phenoxy roxarsone revealed a binding energy -133.3 kcal/mol. This in silico experiment that screened potential arsenic based roxarsone derivative may help in development of new therapeutic drug for COVID-19.
The aging whole blood transcriptome reveals a potential role of FASLG in COVID-19	Chuffa,  Luiz Gustavo,  Souza, et al	bioRxiv	Clinical data| Données cliniques	Considering that all human coronavirus require host cellular molecules to promote infection, this study investigated the aging whole blood transcriptome from the Genotype-Tissue Expression (GTEx) database to explore differentially expressed genes (DEGs) translated into proteins potentially interacting with viral proteins.  By exploring publicly available Single-Cell RNA-Sequencing (scRNA-Seq) data on peripheral blood of SARS-CoV-2-infected patients, the authors found FASLG and CTSW expressed mainly in natural killer (NK) cells and CD8+ (cytotoxic) T lymphocytes whereas BAG3 was expressed in CD4+ T cells, naive T cells, and CD14+ monocytes. The increased expression of FASLG in blood during aging may explain why older patients are more prone to severe acute viral infection complications. These results indicate FASLG as a prognostic candidate and potential therapeutic target for more aggressive clinical manifestation of COVID-19.
A Mitigation Score for COVID-19	Cohen,  JonathanD	arXiv	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	This note describes a simple score to indicate the effectiveness of mitigation against infections of COVID-19 as observed by new case counts. The score includes normalization, making comparisons across jurisdictions possible. The smoothing employed provides robustness in the face of reporting vagaries while retaining salient features of evolution, enabling a clearer picture for decision makers and the public.
Covid-19 infection during autoimmune disease: Study of 2 cases in republic of Guinea	Condé,  K,  Atakla, et al	Pan African Medical Journal	Clinical data| Données cliniques	The objective of this work is to establish the link between autoimmune diseases and a COVID-19 infection in Guinea.  We report the case of two patients aged 52 and 64 years respectively, known to have rheumatoid arthritis (RA) and systemic scleroderma (SDS) admitted with clinical signs suggesting underlying infection with COVID-19. They were tested with RT-PCR, which was positive within hours.
Impact of COVID on College Student Mental Health and Wellness	Copeland,  WE,  McGinnis, et al	Journal of the American Academy of Child and Adolescent Psychiatry	Mental Health | santé mentale	This study tested the impact of the coronavirus disease 2019 (COVID) pandemic on the emotions, behavior, and wellness behaviors of first-year college students.  Externalizing problems (mean = −0.19, 95% CI = −0.06 to 0.33, p = .004) and attention problems (mean = −0.60, 95% CI = −0.40 to 0.80, p < .001) increased after the onset of COVID, but not internalizing symptoms (mean = 0.18, 95% CI = −0.1 to 0.38, p = .06). Students who were enrolled in a campus wellness program were less affected by COVID in terms of internalizing symptoms (β = 0.40, SE = 0.21, p = .055) and attention problems (β = 0.59, SE = 0.21, p = .005) than those who were not in the wellness program. Nightly surveys of both mood (β = −0.10, SE = 0.03, p = .003) and daily wellness behaviors (β = −0.06, SE = 0.03, p = .036), but not stress (β = 0.02, SE = 0.03, p =. 58), were negatively affected by the COVID crisis. The overall magnitude of these COVID-related changes were modest but persistent across the rest of the semester and different from patterns observed in a prior year.
Diabetic retinopathy is independently associated with increased risk of intubation: A single centre cohort study of patients with diabetes hospitalised with COVID-19	Corcillo,  A,  Cohen, et al	Diabetes research and clinical practice	Clinical data| Données cliniques	In our study of 187 patients with diabetes hospitalised with COVID-19 we observed a more than 5 fold increased risk of intubation in patients with diabetic retinopathy. Further studies are required to understand the mechanisms that explain the associations between retinopathy and other indices of microangiopathy with severe COVID-19. © 2020
Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies	Cortese,  M,  Lee, et al	Cell Host and Microbe	Clinical data| Données cliniques	This study employed an integrative imaging analysis to determine morphological organelle alterations induced in SARS-CoV-2-infected human lung epithelial cells. Reports 3D electron microscopy reconstructions of whole cells and subcellular compartments, revealing extensive fragmentation of the Golgi apparatus, alteration of the mitochondrial network and recruitment of peroxisomes to viral replication organelles formed by clusters of double-membrane vesicles (DMVs). These are tethered to the endoplasmic reticulum, providing insights into DMV biogenesis and spatial coordination of SARS-CoV-2 replication. Live cell imaging combined with an infection sensor reveals profound remodeling of cytoskeleton elements. Pharmacological inhibition of their dynamics suppresses SARS-CoV-2 replication. We thus report insights into virus-induced cytopathic effects and provide alongside a comprehensive publicly available repository of 3D datasets of SARS-CoV-2-infected cells for download and smooth online visualization.
Coronary Calcium Score in COVID-19 Hospitalized Patients	Cosyns,  B,  Motoc, et al	JACC: Cardiovascular Imaging	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study assessed that coronary artery calcium (CAC) score on low-dose computed tomography predicts the need for ventilation and death in population of 280 patients with COVID-19. Excluded patients with previous history of cardiovascular disease. Although CAC score indeed predicted the same combined endpoint, adjusting for age made its additional predictive value nonsignificant. Additionally, during the peak of pandemic, access to intensive care unit (ICU) was limited for older patients because of the saturation of ICU beds. In our cohort, mortality was the main driver of events and was artificially higher in the older population (with higher CAC score) not having access to the ICU. Mortality was very low compared with previous series and with our results (4.3% vs. 16.0%), although the authors reported only the mortality in the ICU. In our cohort, among the 72 patients who were transferred to the ICU, 19 (26.4%) patients died.
Estimating actual covid-19 case numbers using cumulative death count-a method of measuring effectiveness of lockdown of non-essential activities: A south African case study	Cox,  L,  Yah, et al	Pan African Medical Journal	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	Here we use an empirical analysis of cumulative death count, transmission-to-death time lag, and infection fatality rate (IFR) to evaluate and estimate the actual cases at a specific time point as a strategy of tracking the spread of COVID-19. We estimate 28,182 cases as of 14 April, compared with 3,465 reported cases. Weekly growth rate of actual cases dropped immediately after lockdown implementation and has remained steady, measuring at 51.2% as of 14 April.
Transformation of a Ferry Ship into a Ship Hospital for COVID-19 Patients	Cremonesi,  P,  Sartini, et al	Int J Environ Res Public Health	Healthcare Response | Réponse des soins de santé	Due to the serious epidemiological emergency, the transformation of a long-distance ferry ship into a hospital ship for COVID-19 patients who were still positive after the acute phase of the illness was carried out to free up hospital beds for patients in the acute phase. The ship was moored in the port of Genoa, the capital of Liguria. The conversion was localized to a single deck, where designated healthcare areas were identified. From 23 March to 18 June 2020, 191 patients were admitted onto the ship; they were provided with high-level healthcare guaranteed by the multi-disciplinary nature of clinical competencies available. Patients had a favorable outcome in all cases, confirmed by their recovery and negative swab results.
Scrutinizing the heterogeneous spreading of COVID-19 outbreak in large territorial countries	Da Silva,  RM,  Mendes, et al	Phys Biol	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	Herewith, we introduce a general method that allows us to compare the pandemic evolution in different localities inside a large territorial country. To evaluate our method, we study the heterogeneous spreading of the COVID-19 outbreak in Brazil and its 27 states.
Psychological Effects of Social Isolation Due to Quarantine in Chile: An Exploratory Study	Dagnino,  P,  Anguita, et al	Frontiers in Psychiatry	Mental Health | santé mentale	An online survey was carried out (the first 2 weeks of lockdown in Santiago), which included sociodemographic data, perceived psychological impact, future concerns, and questions about psychological support. The main perceived psychological impacts were concern (67%) and anxiety (60%). Younger participants had a greater perceived psychological impact (p's < 0.01) and concerns about employment, finances, mental health, stigma, and general health (p's < 0.001). Women reported more perceived psychological impact than men (p's < 0.05). Men reported mainly boredom (χ2 = 11.82, gl = 1, p < 0.001).
The impact of COVID-19 on chronic care according to providers: a qualitative study among primary care practices in Belgium	Danhieux,  K,  Buffel, et al	BMC Fam Pract	Healthcare Response | Réponse des soins de santé	A qualitative study was conducted in 16 primary care practices: 6 solo working, 4 monodisciplinary and 7 multidisciplinary. Three themes emerged: changes in health care organization, risk stratification and self-management support. All participating practices reported drastic changes in organization with a collective shift towards COVID-19 care, and reduction of chronic care activities, less consultations, and staff responsible for self-management support put on hold.
Predictive modeling of COVID-19 death cases in Pakistan	Daniyal,  M,  Ogundokun, et al	Infectious Disease Modelling	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	The primary purpose of this study is to provide the statistical model to predict the trend of COVID-19 death cases in Pakistan. The finding deduced after the prediction modelling is that the rate of mortality would decrease by the end of October. The total number of deaths will reach its maximum point; then, it will gradually decrease.
The inherent problem of pooling: increased false-negative rates	Daon,  Yair,  Huppert, et al	medRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Using a probabilistic model, we analyze the false-negative rate (i.e., the probability of a negative result for an infected individual) of Dorfman pooling. We show that one can expect a 60-80% increase in false-negative rates under Dorfman pooling, for reasonable parameter values. On average, when separate testing misses, e.g., ten infected individuals - Dorfman pooling misses more than sixteen.
Psychological health problems during the lockdown: A survey of Indian population in COVID-19 pandemic	David,  BE,  Kumar, et al	Data in Brief	Mental Health | santé mentale	The dataset presented here is the assessment of the psychological distress experienced by people in India following the implementation of lockdown as a measure to curtail the spread of the coronavirus. The period of data collection is between 9th April 2020 and 20th April 2020 where a total of 1,894 responses were obtained. The data is beneficial for the timely assessment of the nature and degree of the psychological distress experienced by people in India during the COVID-19 crisis.
Chest CT in COVID-19 pneumonia: a correlation of lung abnormalities with duration and severity of symptoms	Dawoud,  MM,  Dawoud, et al	Egyptian Journal of Radiology and Nuclear Medicine	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Our study aimed at the analysis of the lung abnormalities detected by chest CT in COVID-19 pneumonia according to the severity and duration of symptoms. In the early phase (n = 60), 32 patients had negative CT findings and 28 patients had positive findings with a mean total lung severity score of 2.13. We found a high total lung severity score in many patients with mild symptoms with a mean of 14.77 and a low total lung severity score in many patients with moderate to severe symptoms with a mean of 9.14. Conclusion: Chest CT should be used as a routine examination for diagnosing COVID-19 pneumonia and follow-up of disease advance.
Repurposing Known Drugs as Covalent and Non-covalent Inhibitors of the SARS-CoV-2 Papain-Like Protease	Delre,  P,  Caporuscio, et al	Frontiers in Chemistry	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	We present a virtual screening campaign to identify covalent and non-covalent inhibitors of the SARS-CoV-2 papain-like protease (PLpro) showing potential multitarget activities (i.e., a desirable polypharmacology profile) for the COVID-19 treatment. A dataset including 688 phase III and 1,702 phase IV clinical trial drugs was downloaded from ChEMBL (version 27.1) and docked to the recently released crystal structure of PLpro in complex with a covalently bound peptide inhibitor. The obtained results were analyzed by combining protein–ligand interaction fingerprint similarities, conventional docking scores, and MM-GBSA–binding free energies and allowed the identification of some interesting candidates for further in vitro testing.
Acute Cerebrovascular Events With COVID-19 Infection	Dhamoon,  MS,  Thaler, et al	Stroke	Epidemiology| Épidémiologie Clinical data| Données cliniques	We conducted a retrospective observational study of risk factors, stroke characteristics, and short-term outcomes in a large health system in New York City. Baseline characteristics in patients with stroke were similar comparing those with and without COVID-19. However, COVID-19-positive patients were more likely to experience stroke in a lobar location, more commonly had a cryptogenic cause, and had worse outcomes.
The risk for severe COVID 19 in patients with autoimmune and/or inflammatory diseases: First wave lessons	Druyan,  A,  Lidar, et al	Dermatol Ther	Clinical data| Données cliniques	To estimate the risk of those patients to develop a more severe COVID19 infection, all active patients and those with dermatologic and/or rheumatologic autoimmune/inflammatory diseases were identified in a single tertiary center. No statistically significant difference in severity of COVID19 infection or mortality rate was found. The rate of asymptomatic, mild, moderate, severe/critical and fatal COVID19 infection was 11.4%, 37.1%, 22.8%, 11.4% and 17.1% respectively for the patients with autoimmune diseases and 17.8%, 45.8%, 10.9%, 6.8% and 18.4% respectively for the controls . Patients with autoimmune/inflammatory diseases seem not to develop a more severe COVID19 infection than controls.
Medical student-led simulation in COVID-19 crisis	Ekert,  JO,  Luchesa Smith, et al	Clin Teach	Healthcare Response | Réponse des soins de santé	We present a set of medical student-led clinical simulation sessions and evaluate their effects on (i) confidence among redeployed healthcare workers managing COVID-19 patients and (ii) medical students' confidence as educators. Respondents reported being significantly more confident after the training in all aspects of managing COVID-19 patients, including triage, complex discharge, recognising deterioration, initiating basic life support, managing symptoms and advising on visiting policies (p < 0.001).
Evaluating the psychological distress of the coronavirus disease 2019 pandemic in Egypt	El-Abasiri,  R,  Marzo, et al	European Journal of Molecular and Clinical Medicine	Mental Health | santé mentale	This study aimed to assess the psychological status of the general population in Egypt during COVID-19. It was found that 51.9% of HCWs experienced mild to moderate distress, while 15% experienced severe distress. Additionally, non-HCWs' results showed that 39.7% of them experienced mild to moderate distress; 21.8% experienced severe distress (OR: 0.717; 95% CI: 0.493-1.043). Moreover, the percentage of females with severe distress (21.7%) was two times higher than that of males (10.7%) (OR: 0.412; 95% CI: 0.278-0.612).
Circulating ACE2-expressing Exosomes Block SARS-CoV-2 Virus Infection as an Innate Antiviral Mechanism	El-Shennawy,  Lamiaa,  Hoffmann, et al	bioRxiv	Therapeutics| Thérapeutique	Herein, we detected circulating exosomes that express the SARS-CoV-2 viral entry receptor angiotensin-converting enzyme 2 (ACE2) in plasma of both healthy donors and convalescent COVID-19 patients. We demonstrated that exosomal ACE2 competes with cellular ACE2 for neutralization of SARS-CoV-2 infection. ACE2-expressing (ACE2+) exosomes blocked the binding of the viral spike (S) protein RBD to ACE2+ cells in a dose dependent manner, which was 400- to 700-fold more potent than that of vesicle-free recombinant human ACE2 extracellular domain protein (rhACE2). As a consequence, exosomal ACE2 prevented SARS-CoV-2 pseudotype virus tethering and infection of human host cells at a 50-150 fold higher efficacy than rhACE2. A similar antiviral activity of exosomal ACE2 was further demonstrated to block wild-type live SARS-CoV-2 infection. Of note, depletion of ACE2+ exosomes from COVID-19 patient plasma impaired the ability to block SARS-CoV-2 RBD binding to host cells.
Logistical, Financial, and Psychological Impact of the COVID-19 Pandemic on Cardiac Catheterization Lab Nurses and Technologists: A U.S. National Survey	Estes,  BA,  Varghese, et al	J Invasive Cardiol	Mental Health | santé mentale Healthcare Response | Réponse des soins de santé	A national, online survey was conducted for nurses and technologists working in the cardiac catheterization laboratory (CCL) in the United States. A total of 450 respondents completed the survey, including 283 nurses (63%) and 167 technologists (37%). 74% experienced >75% decrease in case volume despite a low inpatient COVID-19 census (54% of respondents with census <10%). There were high rates of direct care for COVID-19 patients (47%), relocation (45%), lay-off/furloughs of part-time or per diem staff (42%), lay-offs of full-time staff (12%), and decreased work hours (65%). A total of 95% expressed decreased morale with an increase in mental distress, including depression (36%). Predictors of depression included relocation status, staff preparedness, and work hours.
Low assets and financial stressors associated with higher depression during COVID-19 in a nationally representative sample of US adults	Ettman,  CK,  Abdalla, et al	J Epidemiol Community Health	Mental Health | santé mentale	We assessed the relation between assets, financial stressors and probable depression during the COVID-19 pandemic. Populations with low assets are bearing a greater burden of mental illness during the COVID-19 pandemic.
Spectrum of cardiovascular diseases in children during high peak COVID-19 period infection in Northern Italy: is there a link?	Fabi,  M,  Filice, et al	J Pediatric Infect Dis Soc	Clinical data| Données cliniques	We describe the spectrum of cardiovascular manifestations during a COVID-19 outbreak in Emilia-Romagna, Italy. KD, myocarditis and MIS-C were distinguishable cardiovascular manifestations. KD did not show a more aggressive form compared to previous years: coronary involvement was frequent, but always transient. MIS-C and myocarditis rapidly responded to treatment without cardiac sequelae despite high markers of myocardial injury at onset suggesting a myocardial depression due to systemic inflammation rather than focal necrosis.
Periodontal tissues are targets for Sars-Cov-2: a post-mortem study	Fernandes Matuck,  B,  Dolhnikoff, et al	Journal of Oral Microbiology	Clinical data| Données cliniques	The aim of this study was to investigate the presence of SARS-CoV-2 in periodontal tissue.  The seven studied autopsies with positive laboratory tests for COVID-19 included 57.14% of female patients at the average age of 47.4 (range 8 to 74). In five cases, periodontal tissue was positive for SARS-CoV-2 (RT-PCR). Histopathologic analyses showed morphologic alterations in the keratinocytes of the junctional epithelium, a vacuolization of the cytoplasm and nucleus and nuclear pleomorphism.
Involuntary Movements Following Administration of Hydroxychloroquine for COVID-19 Pneumonia	Fernando,  EZ,  Yu, et al	J Mov Disord	Clinical data| Données cliniques	We present a case of a 38-year-old male who was started on HCQ for COVID-19 pneumonia. He was referred for evaluation of myoclonus of all extremities, which resolved after discontinuation of HCQ. The involuntary movements were first reported after the initiation of HCQ, persisted despite improvement in inflammatory and radiologic parameters and eventually resolved after HCQ discontinuation.
Seroprevalence of anti-SARS-CoV-2 antibodies in COVID-19 patients and healthy volunteers up to 6 months post disease onset	Figueiredo-Campos,  P,  Blankenhaus, et al	European journal of immunology	Epidemiology| Épidémiologie Immunology | Immunologie	To understand the continuing spread of the virus, to detect those who are and were infected, and to follow the immune response longitudinally, reliable and robust assays for SARS-CoV-2 detection and immunological monitoring are needed. We report the detailed setup to monitor the humoral immune response from over 300 COVID-19 hospital patients and healthcare workers, 2500 University staff, and 198 post-COVID-19 volunteers. Anti-SARS-CoV-2 antibody responses follow a classic pattern with a rapid increase within the first three weeks after symptoms. Although titres reduce subsequently, the ability to detect anti-SARS-CoV-2 IgG antibodies remained robust with confirmed neutralization activity for up to 6 months in a large proportion of previously virus-positive screened subjects.
Quality of life and depressive symptoms among Peruvian university students during the COVID-19 pandemic	Figueroa-Quiñones,  Joel,  Ipanaqué-Zapata, et al	bioRxiv	Mental Health | santé mentale	This study aimed to characterize the quality of life and depressive symptoms of university students in Peru during the COVID-19 pandemic and to determine the associated factors. Almost half and one third of participants reported anxiety/depression, and pain/discomfort in their QoL respectively. Nearly a third presented moderate and severe depressive symptoms. The deterioration of QoL was worse in those who had a decrease in income and a family member with chronic illness.
The impact of the COVID-19 pandemic on mental health and well-being of people living with a long-term physical health condition: a qualitative study	Fisher,  Abigail,  Roberts, et al	medRxiv	Mental Health | santé mentale	The aim of this study was to qualitatively explore how living with a long-term physical health condition (LTC) during the COVID-19 pandemic affected mental health and wellbeing.  This study found that there were a number of aspects of living with a LTC during the pandemic that had a significant impact on mental health and well-being.
PMC7710351; 2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease	Forrestall,  KL,  Burley, et al	Chem Biol Interact	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	A search for natural, antimicrobial products with the 2-pyridone moiety was undertaken herein, and their calculated potency as inhibitors of SARS-CoV-2 M(pro) was investigated. Thirty-three natural products containing the 2-pyridone scaffold were identified from the literature. An in silico methodology using AutoDock was employed to predict the binding energies and inhibition constants (K(i) values) for each 2-pyridone-containing compound with SARS-CoV-2 M(pro). This work has identified 2-pyridone natural products with calculated potent inhibitory activity against SARS-CoV-2 M(pro) and with desirable drug-like properties, which may lead to the rapid discovery of a treatment for COVID-19.
Automatic Detection of COVID-19 from Chest X-ray Images with Convolutional Neural Networks	Foysal Haque,  K,  Farhan Haque, et al		Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	A CNN model is proposed to detect COVID-19 patients from chest X-ray images. This model is evaluated with a comparative analysis of two other CNN models. The proposed model performs with an accuracy of 97.56% and a precision of 95.34%. This model gives the Receiver Operating Characteristic (ROC) curve area of 0.976 and F1-score of 97.61. It can be improved further by increasing the dataset for training the model.
Antiviral activity of plant juices and green tea against SARS-CoV-2 and influenza virus in vitro	Frank,  Bruno,  Conzelmann, et al	bioRxiv	Therapeutics| Thérapeutique	We here analyzed the virucidal activity of black chokeberry (Aronia melanocarpa), pomegranate (Punica granatum), and elderberry (Sambucus nigra) juice, as well as green tea (Camellia sinensis) against different respiratory viruses. We found that all tested plant derived products effectively inactivated influenza virus, whereas only chokeberry juice diminished SARS-CoV-2 and vaccinia virus infectivity. None of the products inactivated non-enveloped human adenovirus type 5. Thus, black chokeberry juice exerts virucidal activity against different enveloped viral pathogens under in vitro conditions.
COVID-19, storms, and floods: Impacts of tropical storm cristobal in the western sector of the Yucatan Peninsula, Mexico	Frausto-Martínez,  O,  Aguilar-Becerra, et al	Sustainability (Switzerland)	Epidemiology| Épidémiologie	This work aims to determine whether the presence of concurrent events during the pandemic caused an increase in confirmed positive COVID-19 cases in the Yucatan Peninsula’s western sector. To achieve this, a numerical analysis and identification of the tropical storm’s extreme characteristics were conducted. From the analyzed data, it can be pointed out that there is no direct evidence for an increase in positive COVID-19 cases in 10 of the municipalities.
Legal origins and government COVID-19 control measures	Fredriksson,  PG,  Gupta, et al	Applied Economics Letters	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	A speedy response made a significant difference to the number of infections and deaths due to COVID-19. Did legal philosophies matter for policy responses? We find that when 100 cases had been diagnosed (and 7–14 days thereafter), common law countries had implemented weaker measures than civil law countries. However, no significant difference is found for COVID-19 related deaths. Lower vulnerability is also associated with weaker policies.
Why simple face masks are unexpectedly efficient in reducing viral aerosol transmissions	Freitag,  Steffen,  Howell, et al	medRxiv	Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)	Here we show that this apparent inconsistency can be resolved with a simple face mask model that combines our filtration efficiency measurements of various mask materials with existing data on exhaled aerosol characteristics. Our model also shows that thin fabric masks provide protection for the wearer from aerosols expelled by another person reducing inhaled viral load by up to 20 % and 50 % and if leaks are avoided up to 35 % and 90 % for breath and speech, respectively.
Comparative analysis of antigen-specific anti-SARS-CoV-2 antibody isotypes in COVID-19 patients	Fujigaki,  Hidetsugu,  Inaba, et al	bioRxiv	Clinical data| Données cliniques Immunology | Immunologie	This study aimed to investigate the kinetics and neutralizing activity of various antigen-specific antibody isotypes against SARS-CoV-2 in serum of COVID-19 patients confirmed via polymerase chain reaction test. The sensitivity of all antigen-specific antibody isotypes depended on the timing of the serum collection and all of them, except for IgM against N protein, reached more than 90% at 15-21 days post-symptom onset. The best correlation with virus neutralizing activity was found for IgG against RBD (RBD-IgG), and levels of RBD-IgG in sera from four severe COVID-19 patients increased concordantly with neutralizing activity.
Change in Patient Flow in the Epilepsy Care Network Due to Novel Coronavirus Infection: An Opportunity to Strengthen Local Interdisciplinary Epilepsy Care With General Physicians	Fujimoto,  A,  Sato, et al	Frontiers in Neurology	Healthcare Response | Réponse des soins de santé	We hypothesized that patient flow in epilepsy care would change as a result of the COVID-19 pandemic. The purpose of this study was to compare the number of patients who visited our epilepsy center before and during the first peak of the pandemic. Patient flow in the epilepsy care network changed as a result of the COVID-19 pandemic.
Upper extremity emergencies during SARS-COV-2 pandemic: Turnout trends	Fyllos,  A,  Varitimidis, et al	Injury	Healthcare Response | Réponse des soins de santé	This study compared the turnout of patients with upper extremity (UE) and hand & wrist (H&W) emergencies during the SARS-COV-2 pandemic, with the same period of 2019, in the public and private sector. During the pandemic, the number of patients with orthopaedic, UE, and H&W problems was significantly reduced by 57.09%, 49.77%, 49.92% respectively (p<0.001) compared to 2019.
Adequate anticoagulation and ECMO therapy in COVID-19 patients with severe pulmonary embolism	Gaisendrees,  C,  Walter, et al	Perfusion	Clinical data| Données cliniques	This paper reports on a 55-year-old female COVID-19 patient with severe ARDS and pulmonary embolism (PE) complicated by cardiogenic shock after 12 days of hospitalization under initial prophylactic anticoagulation with low molecular weight heparin (LMWH).
First-described recently discovered non-toxic vegetal-derived furocoumarin preclinical efficacy against SARS-CoV-2: a promising antiviral herbal drug	Galindo-Cardiel,  Ivan,  Toledo Nunez, et al	bioRxiv	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Here we show that ICEP4 presents a significant in vitro cytoprotective effect in highly virulent-SARS-CoV-2 challenged Vero E6 cellular cultures by using 34.5 and 69 μM doses. No dose related ICEP4 toxicity was seen on Vero E6 cells, M0 macrophages, B, CD4+ T and CD8+ T lymphocytes, Natural Killer (NK) and Natural Killer T (NKT) cells. No dose related ICEP4 inflammatory response was observed in M0 macrophages quantified by IL6 and TNFα release in cell supernatant. No survival rate decrease was observed neither on 24-hour acute nor 21-days chronic in vivo toxicity studies performed in C. elegans. Therefore, ICEP4 toxicological profile has demonstrated marked differences compared to others vegetal furocoumarins.
Loneliness and depression in patients with cancer during COVID-19	Gallagher,  S,  Bennett, et al	J Psychosoc Oncol	Mental Health | santé mentale	Five hundred and eighteen people with cancer with data extracted from two waves (2017-19 and April 2020) of the Understanding Society UK dataset participated. An increased risk of depression was observed for cancer of the breast, prostate, blood, but not other cancers (e.g., lung, melanoma). After controlling for prior depression and other factors, it was loneliness during COVID-19, and not previous loneliness, that was predictive. Those currently lonely had a 4.5-fold increased risk of depression.
Content analysis of social and economic issues in Indonesia during the COVID-19 pandemic	Gandasari,  D,  Dwidienawati, et al	Heliyon	Public Health response| Interventions de santé publique	The questions of this research are (1) what social issues were reported in the online news media during the early days of the COVID-19 pandemic, and (2) what economic issues were reported in the online news media during the same period. This study aims to identify the content of news when conveying COVID-19 pandemic information based on the frequency of appearance and news content based on social and economic issues in online news. The results showed that Antara News used text, photos, videos and graphics 1,847 times for social issues and 2,701 times for economic issues related to COVID-19. The social issues involved 20 themes. Some of the important ones included regulations, social funds and charities, the humanities, the availability of infrastructure facilities, education, instruction and appeal, and culture and religion.
Understanding and monitoring the evolution of the Covid-19 epidemic from medical emergency calls: The example of the Paris area	Gaubert,  S,  Akian, et al	Comptes Rendus Mathematique	Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé	We portray the evolution of the Covid-19 epidemic during the crisis of March–April 2020 in the Paris area, by analyzing the medical emergency calls received by the EMS of the four central departments of this area (Centre 15 of SAMU 75, 92, 93 and 94). Our study reveals strong dissimilarities between these departments. We show that the logarithm of each epidemic observable can be approximated by a piecewise linear function of time. This allows us to distinguish the different phases of the epidemic, and to identify the delay between sanitary measures and their influence on the load of EMS.
Challenges in treatment of patients with acute leukemia and COVID-19: a series of 12 patients	Ghandili,  S,  Pfefferle, et al	Blood Adv	Clinical data| Données cliniques	We report a series of 12 patients with AL and SARS-CoV-2 infection who were treated in our department between 18 March and 18 May 2020.
Development of a novel platform of virus-like particle (VLP)-based vaccine against COVID-19 by exposing epitopes: an immunoinformatics approach	Ghorbani,  A,  Zare, et al	New Microbes and New Infections	Coronavirology| Coronavirologie	The present study aimed to predict immunogenic epitopes in silico by analyzing the spike protein. In parallel, by screening the immunogenic SARS-CoV-2 spike-derived epitopes provided in the literature, we chose a set of epitopes that we believed would induce immunogenic response. We report for the first time the comparison of the nucleotide sequences of an Iranian isolate of SARS-CoV-2 with other countries, including China, the Netherlands, Japan, Turkey, Pakistan, South Korea, Finland, Australia and the United States. Our analysis showed that the S protein is conserved between isolates from different countries with 100% and 99% similarity. e also compared all of the abovementioned SARS-CoV-2 isolates with bat SARS-like and SARS viruses, which showed about 72% and 75% similarity with SARS and bat SARS-like respectively.
Growth of Ambulatory Virtual Visits and Differential Use by Patient Sociodemographics at One Urban Academic Medical Center During the COVID-19 Pandemic: Retrospective Analysis	Gilson,  SF,  Umscheid, et al	JMIR Med Inform	Healthcare Response | Réponse des soins de santé	The aim of this study was to examine changes in ambulatory visit volume and type (ie, in-person vs virtual and telephone vs video visits) by patient sociodemographics during the COVID-19 pandemic at one urban academic medical center. Total visit volumes in the COVID-19 study period comprised 51.4% of the corresponding weeks in 2019. Although patient sociodemographics between the COVID-19 study period in 2020 and the corresponding weeks in 2019 were similar, 60.5% (n=48,475) of the visits were virtual, compared to 0% in 2019.
Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity	Giroux,  NicholasS,  Ding, et al	bioRxiv	Clinical data| Données cliniques Immunology | Immunologie	We sought to harness the peripheral blood mononuclear cell (PBMC) response over the course of illness to provide insight into COVID-19 physiology.  Our findings indicate that pre-seroconversion chromatin remodeling in certain innate immune populations is associated with divergence in symptom severity, and the identified transcription factors, regulatory elements, and downstream pathways provide potential prognostic markers for COVID-19 subjects.
Incidence rates of hospitalization and death from COVID-19 in patients with psoriasis receiving biological treatment: A Northern Italy experience	Gisondi,  P,  Piaserico, et al	Journal of Allergy and Clinical Immunology	Epidemiology| Épidémiologie	We sought to investigate the incidence of hospitalization and death for COVID-19 in a large sample of patients with plaque psoriasis receiving biologic therapies compared with the general population. The incidence rate of hospitalization for COVID-19 was 11.7 per 10,000 person-months in patients with psoriasis and 14.4 in the general population; the incidence rate of death from COVID-19 was 1.3 and 4.7 in patients with psoriasis and the general population, respectively.  Our data did not show any adverse impact of biologics on COVID-19 outcome in patients with psoriasis.
Prominent Longitudinal Strain Reduction of Basal Left Ventricular Segments in Patients With Coronavirus Disease-19: Reduced Basal Strain in COVID-19	Goerlich,  E,  Gilotra, et al	Journal of cardiac failure	Epidemiology| Épidémiologie Clinical data| Données cliniques	We hypothesized that patients with COVID-19 with reduced basal LV strain would demonstrate elevated cardiac biomarkers. Of 75 included patients, 52% had reduced basal strain. Cases had higher body mass index, and greater proportions of Black, hypertensive, and diabetic patients compared with controls. Troponin and N-terminal pro-brain natriuretic peptide levels trended higher in cases, but were not significantly different.
The Impact of COVID-19 on nurses working in a University Health System in Singapore: A qualitative descriptive study	Goh,  YS,  Ow Yong, et al	Int J Ment Health Nurs	Healthcare Response | Réponse des soins de santé	This study used a qualitative descriptive design to explore nurses' experiences of working in tertiary hospitals during the COVID-19 pandemic. Three main themes emerged: (i) challenging moments of COVID‐19, during which the participants reported physical and psychological challenges relating to working conditions of the hospital in the initial months of the pandemic; (ii) the professional role as nurses, in where the participants dispelled their worries and demonstrated commitment to their role as nurses; and (iii) support for nurses, which originated from their family, friends and leaders from their organizations for them to persevere and overcome the unprecedented challenges of COVID‐19.
Understanding attitudes, concerns, and health behaviors of patients with inflammatory bowel disease during the coronavirus disease 2019 pandemic	Goodsall,  TM,  Han, et al	Journal of Gastroenterology and Hepatology (Australia)	Public Health response| Interventions de santé publique	We aimed to prospectively evaluate the attitudes, concerns, and health behavior of IBD patients during COVID‐19. Of 97 respondents (39%), 95 (98%) reported concern about the impact of COVID‐19 on their health, and 43% felt their risk of contracting COVID‐19 was above average; 62% reported concern about medication‐induced COVID‐19 risk, and 11% stopped medications because of COVID‐19. Patients considered all medications to increase the risk of COVID‐19 susceptibility and severity; 45% preferred telehealth while 16% preferred face‐to‐face clinic reviews.
Compassionate use of tocilizumab in severe SARS-CoV2 pneumonia	Górgolas Hernández-Mora,  M,  Cabello Úbeda, et al	International Journal of Infectious Diseases	Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique	We administered TCZ on a compassionate-use basis to patients with severe SARS-CoV-2 pneumonia (SSP) who were hospitalized (excluding intensive care and intubated cases) and who required oxygen support to have a saturation >93%. Prognostic factors of death were older age, higher IL-6, d-dimer and high-sensitivity C-reactive protein (HSCRP), lower total lymphocytes, and severe disease that requires additional oxygen support. The primary endpoint (intubation or death) was significantly worst (37% vs 13%, p < 0.001) in those receiving the drug when the oxygen support was high (FiO2 >0.5%).
COVID-19: How do emergency departments fare after normalization steps?	Görmeli Kurt,  N,  Çamcı, et al	Int J Clin Pract	Healthcare Response | Réponse des soins de santé	Herein, we aimed to investigate the reflections of our otherwise crowded emergency services’ quietness in the period of normalization. The number of emergency service admissions in the ‘Period of Restrictions’ was significantly lower. There was no statistically significant difference between the ‘Period of Pre‐pandemic Normal’ and the ‘Period of Normalization’ in terms of the number of emergency service admissions. A total of 24 (0.03%) patients died in the ‘Period of Pre‐pandemic Normal’ while 172 (0.23%) patients died in the ‘Period of Normalization’.
Retrospective Analysis of Asymptomatic COVID-19 Patients Presenting to Emergency Department	Gormeli Kurt,  N,  Gunes, et al	Int J Clin Pract	Clinical data| Données cliniques	In the present study we aimed to investigate the clinical and demographic characteristics of asymptomatic COVID‐19 cases incidentally diagnosed at the emergency department. Only 42 (48%) patients had a history of suspected contact with a COVID‐19 positive individual. The mean time to symptom onset of 81 patients was 5±2 days. An analysis based on thoracic computerized tomography findings showed that the common finding found in all patients was ground glass opacity (GGO). While 55 (68%) patients had GGO alone, 10 (12%) had additional fine reticulations; 6 (7%) had an additional halo sign; 6 (7%) had an additional air bronchogram; and 4 (5%) had an additional area of consolidation. None of the patients died during follow‐up, and all of them were discharged.
SARS-CoV-2-Associated Acute Transverse Myelitis in Panama with Analysis of 38 Cases Reported Worldwide During COVID-19	Gracia,  Fernando,  Roman, et al	SSRN- Lancet prepublication	Clinical data| Données cliniques	We report a 72-year-old man with SARS-CoV-2-associated cervicothoracic ATM in Panama, and analyze the results of a bibliographic investigation on myelitis during COVID-19.
Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study	Grassin-Delyle,  S,  Roquencourt, et al	EBioMedicine	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The objective of the current study was to characterize exhaled breath from mechanically ventilated adults with COVID-19. Between March 25th and June 25th, 2020, we included 40 patients with ARDS, of whom 28 had proven COVID-19. In a multivariate analysis, we identified a characteristic breathprint for COVID-19. We could differentiate between COVID-19 and non-COVID-19 ARDS with accuracy of 93% (sensitivity: 90%, specificity: 94%, area under the receiver operating characteristic curve: 0.94-0.98, after cross-validation). The four most prominent volatile compounds in COVID-19 patients were methylpent-2-enal, 2,4-octadiene 1-chloroheptane, and nonanal.
Functional profile, homing and residency of protective T cell immune responses against SARS-CoV-2	Grau-Expósito,  Judith,  Sánchez-Gaona, et al	medRxiv	Clinical data| Données cliniques Immunology | Immunologie	We studied T cell functions, migration patterns and apoptosis associated with antigen responses in three groups of patients during acute infection. Hospitalization and disease severity were associated with predominant IFNg and IL-4 responses, as well as increased responses against S peptides and apoptosis, while non-hospitalized patients were characterized by IL-10 secretion, to which a particular subset expressing high levels of CCR7 contributed abundantly. Importantly, lung-resident memory T cells were strongly detected in convalescent patients, in which contemporary blood did not reflect tissue resident profiles. Our results suggest that a balanced anti-inflammatory antiviral response promoted by non-spike proteins may be key to favor infection resolution without major complications.
PMC7716111; Individual differences in susceptibility to false memories for COVID-19 fake news	Greene,  CM,  Murphy, et al	Cogn Res Princ Implic	Public Health response| Interventions de santé publique	The present study measured susceptibility to false memories following exposure to fabricated news stories about the pandemic in a sample of 3746 participants. Notably, objectively and subjectively assessed knowledge about COVID-19 were not significantly correlated.  Objectively assessed knowledge was associated with fewer false memories but more true memories, suggesting a true discrimination between true and fake news. In contrast, participants who merely believed themselves to be very knowledgeable were more likely to report a memory for true stories, but showed no reduction in false memories. Similarly, individuals who reported high levels of media engagement or anxiety about COVID-19 reported an increase in true (but not false) memories.
Coronavirus Disease 2019 (COVID-19)-Related Multisystem Inflammatory Syndrome in a Pregnant Woman	Gulersen,  M,  Staszewski, et al	Obstet Gynecol	Clinical data| Données cliniques	A multiparous woman at 28 weeks of gestation, diagnosed with COVID-19 4 weeks prior, was admitted with chest pain. The patient developed cardiogenic shock and required mechanical ventilation.
Is Mean Platelet Volume a Predictive Marker for the Diagnosis of COVID-19 in Children?	Gumus,  H,  Demir, et al	Int J Clin Pract	Epidemiology| Épidémiologie Clinical data| Données cliniques	AIM: To investigate the mean platelet volume (MPV) in asymptomatic children infected with COVID-19. RESULTS: The MPV values were determined to be statistically significantly high (p0.05). The optimal cutoff point for MPV was determined as 8.74 fl with 81.82% sensitivity and 95% specificity for the determination of children infected with COVID-19. Based on the ROC analysis, the sensitivity and specificity of MPV was determined to be higher than that of lymphocyte levels.
Transmission of SARS-CoV-2 Infection by Children: A Study of Contacts of Index Paediatric Cases in India	Gupta,  N,  Saravu, et al	J Trop Pediatr	Clinical data| Données cliniques	The aim of this study was to understand the transmission dynamics of Severe Acute Respiratory Syndrome Coronavirus 2 in children. This was a retrospective observational study where a total of 19 paediatric index cases (including a set of twins) with COVID-19 and 42 primary contacts (adults—36, paediatric—6) from the immediate family members were included. All the index cases and four of the five positive contacts were asymptomatic. Despite adults staying with positive children in the same vehicle, same room in the quarantine centre and the same ward, only four of the parents became positive.
Social mixing and risk exposures for SARS-CoV-2 infections in elderly persons	Haag,  C,  Höglinger, et al	Swiss Med Wkly	Public Health response| Interventions de santé publique	The present study examined persons aged 65 years and older with respect to possible SARS-CoV-2 exposure risks using longitudinal panel data from the Swiss COVID-19 Social Monitor. Adherence to established preventive measures was similar across the two surveys, whereas adherence pertaining to social contacts decreased substantially from survey “May” to survey “August”. Analysis to identify at-risk elderly individuals yielded four distinct groups with regard to different patterns of adherence to recommended preventive measures: a larger group of individuals with many social contacts but high self-reported adherence to preventive measures (n = 86); a small group with many social contacts and overall lower adherence (n = 26); a group with comparatively few contacts and few social activities (n = 66); and a group which differed from the latter through fewer contacts but more social activities (n = 78).
Factors related to Pregnancy Outcome Among Lebanese Women During COVID-19 Confinement	Haddad,  Chadia,  Bou Malhab, et al	Research Square prepub	Public Health response| Interventions de santé publique Healthcare Response | Réponse des soins de santé	The objective of this study was to evaluate the socio-economic and psychological factors related to current pregnancy status and unwanted pregnancy among a sample of Lebanese women during the COVID-19 lockdown. Results: Higher psychological violence would negatively affect pregnancy, but the association tended to significance (p=0.065). Also, regular visits to the physician for routine checkups (ORa=0.053) were significantly associated with lower odds of unwanted pregnancy. Higher psychological violence would affect unwanted pregnancy; however, the association tended to significance (p=0.056).
Elevated SARS-CoV-2 Antibodies Distinguish Severe Disease in Early COVID-19 Infection	Haddad,  NatalieS,  Nguyen, et al	bioRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie	In this study, we developed a sensitive anti-SARS-CoV-2 immunoassay using pre-pandemic controls and RT-PCR-confirmed, SARS-CoV-2-infected patients and observed higher antibody levels earlier in patients with severe/critical infections compared to those with mild/moderate disease. From days 6-30 post-symptom onset, the levels of antigen-specific IgG, IgA or [IgA+IgG+IgM] were higher in patients with severe/critical compared to mild/moderate infections. Consistent with excessive concentrations of antibodies, a strong prozone effect was observed in sera from severe/critical patients. Notably, mild/moderate patients displayed a slower rise and lower peak in anti-N and anti-S1 IgG levels compared to severe/critical patients, but anti-RBD IgG and neutralization responses reached similar levels at 2-4 months.
Predicting Criticality in COVID-19 Patients	Hallman,  RA,  Chikkula, et al		Healthcare Response | Réponse des soins de santé	To assist clinical staff in deciding which patients are in the greatest need of critical care, we develop a predictive model based on a publicly-Available data set that is rich in clinical markers. We create a predictive model that will assist clinical personnel in determining COVID-19 patient prognosis.  Mild COVID-19 infections where the patient is not admitted to the hospital are characterized by low levels of hs-CRP and ALT, as well as a relatively normal neutrophil count. ICU admission is appropriate for the most critical infections, which are characterized by higher hs-CRP and low base excess levels.
PMC7709786; Systematic Duplex Ultrasound Screening in Conventional Units for COVID-19 Patients with Follow-up of 5 Days	Hamadé,  A,  Jambert, et al	J Vasc Surg Venous Lymphat Disord	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objective of this work was to evaluate the prevalence of deep venous thrombosis of lower limbs (DVT) through ultrasonography in patients infected with COVID-19 admitted to hospital in conventional units with 5 days monitoring. Hospitalized non ICU patients with COVID-19 pneumonia have a high frequency of venous thrombotic events justifying screening with duplex ultrasound. We found a significant association between acute DVT and D-dimer levels.
A Non-severe Coronavirus Disease 2019 Patient With Persistently High Interleukin-6 Level	Hambali,  NL,  Mohd Noh, et al	Frontiers in Public Health	Clinical data| Données cliniques	We present here a case of a 55-year-old male COVID-19 patient with an unusual high level of interleukin 6 (IL-6). Further investigation revealed he had hepatocellular carcinoma (HCC) with underlying hepatitis B.
Submillisievert chest CT in patients with COVID-19 - experiences of a German Level-I center	Hamper,  CM,  Fleckenstein, et al	European Journal of Radiology Open	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The aim of this study was to evaluate parameter settings for two commonly used CT scanners to ensure sufficient image quality/diagnostic confidence at a submillisievert dose. With the tested parameter settings we achieved effective doses below 1 mSv  in all 36 patients. Thirty-four patients had typical COVID-19 findings. Both readers were confident regarding the typical COVID-19 CT-characteristics in all cases.
Comparison of the clinical manifestations between different age groups of patients with overseas imported COVID-19	Han,  Y,  Luo, et al	PLoS One	Epidemiology| Épidémiologie Clinical data| Données cliniques	The current study investigated the clinical manifestations and outcomes of different age groups of patients with overseas imported COVID-19.  Based on the percentage of disease aggravation during hospital stay according to CT, the patients were divided into two groups: ≤40 years (group A; n = 41) and >40 years (group B; n = 12). According to clinical typing, compared with group A, group B had a significantly greater proportion of the common type of COVID-19 and greater comorbidity of type 2 diabetes. Group B showed significantly more frequent CT abnormalities, with greater proportions of multiple lesions and bilateral lung involvement. During hospitalization, group B had a greater proportion of disease aggravation according to CT. Compared with group A, group B received a significantly greater proportion of antiviral therapy and presented a significantly greater occurrence of adverse drug reactions.
Reverse transcriptase loop-mediated isothermal amplification (RT-LAMP)-based diagnosis: A potential alternative to quantitative real-time PCR based detection of the novel SARS-COV-2 virus	Haq,  F,  Sharif, et al	Saudi Journal of Biological Sciences	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	This study will validate the use and efficiency of the reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) assay as a potential alternative for the detection of COVID-19.  ased on a comparative assessment, 117 out of 124 positive COVID-19 cases were observed using the RT-LAMP technique with an overall 91.45% sensitivity. Interestingly, where a consensus on 163 individuals free of SARS-Cov-2 was observed, RT-LAMP specificity was 90%.
Public perception on lockdown for covid-19 - A survey	Harini,  M,  Lakshmanan, et al	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	This study aims to view the public perception of imposed lockdown on them. From the study population, the whole of 100% of the participants gave a positive response when asked if they were aware of COVID-16 and were also aware of the lockdown situation. 100% of the population think that the lockdown for COVID-19 is highly essential in order to completely eradicate the virus.
Knowledge and perception on the transmission and control of SARS-COV-2 infection among allied radiation medicine professionals in Ghana	Hasford,  F,  Sosu, et al	Health and Technology	Healthcare Response | Réponse des soins de santé	This study assessed the level of knowledge on SARS-COV-2 infection prevention, transmission and symptoms of COVID-19, as well as perceptions regarding prevention of SARS-COV-2 infection among allied radiation medicine professionals. Overall, the extent of knowledge among allied radiation medicine professionals on the symptoms of COVID-19, transmission and control of SARS-COV-2 infection in radiation medicine facilities were all adequate, with weighted average indices of 3.8, 4.1 and 4.4 respectively. The facts about COVID-19 that were identified to be most known were shortness of breath being a serious symptom of the disease and fever being a common symptom. The extent of knowledge on the fact that “SARS-COV-2 infection can be transmitted through small droplets from the nose or mouth of an infected person” was almost excellent, with weighted average index of 4.9.
M-polar Neutrosophic Generalized Weighted and m-polar Neutrosophic Generalized Einstein Weighted Aggregation Operators to Diagnose Coronavirus (COVID-19)	Hashmi,  MR,  Riaz, et al	Journal of Intelligent and Fuzzy Systems	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In this article, we propose the generalized weighted aggregation and generalized Einstein weighted aggregation operators in the context of m-polar neutrosophic numbers (MPNNs). We have developed some hybrid generalized weighted aggregation operators based on MPNNs and use them into MCDM for medical diagnosis of COVID-19.
Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of the induction of IFN-mediated innate immune defences	Herder,  Vanessa,  Dee, et al	bioRxiv	Clinical data| Données cliniques	We show that temperature elevation induces wide-spread transcriptome changes that impact upon the regulation of multiple pathways, including epigenetic regulation and lncRNA expression, without disruption of general cellular transcription or the induction of interferon (IFN)-mediated antiviral immune defences. Respiratory tissue incubated at temperatures >37°C remained permissive to SARS-CoV-2 infection but severely restricted the initiation of viral transcription, leading to significantly reduced levels of intraepithelial viral RNA accumulation and apical shedding of infectious virus.
SARS-CoV-2 IgG seroprevalence among medical staff in a general hospital that treated patients with COVID-19 in Japan: retrospective evaluation of nosocomial infection control	Hibino,  M,  Iwabuchi, et al	Journal of Hospital Infection	Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie	We assessed 806 medical staff during an annual medical check-up conducted between 1st June and 30th July 2020. Apart from one staff member who had mild COVID-19 in April 2020, none of the staff had been confirmed to have COVID-19 at any time.  Six medical staff had IgG antibodies against SARS-CoV-2.  Five of these cases were unexpected as they had not been diagnosed previously. Four cases had been asymptomatic in the months preceding the test, and one  visited our fever clinic twice in April with typical COVID-19 symptoms. The SARS-CoV-2 IgG seropositive rate was 0% among medical staff with direct contact with patients with COVID-19, and 0.90% among medical staff without direct contact with patients with COVID-19.
An automatic approach based on CNN architecture to detect Covid-19 disease from chest X-ray images	Hira,  S,  Bai, et al	Applied Intelligence	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In this paper, we proposed a deep learning based approach that can differentiate COVID- 19 disease patients from viral pneumonia, bacterial pneumonia, and healthy (normal) cases. In this paper, we have used nine convolutional neural network based architecture (AlexNet, GoogleNet, ResNet-50, Se-ResNet-50, DenseNet121, Inception V4, Inception ResNet V2, ResNeXt-50, and Se-ResNeXt-50). Experimental results indicate that the pre trained model Se-ResNeXt-50 achieves the highest classification accuracy of 99.32% for binary class and 97.55% for multi-class among all pre-trained models.
Favipiravir for COVID-19 in a Patient on Hemodialysis	Hirai,  D,  Yamashita, et al	American Journal of Kidney Diseases	Clinical data| Données cliniques	A 72-year-old man presented with fever and cough at an outside hospital. After computed tomography of the chest showed left lower lobe consolidation, he was transferred to our hospital.
The characteristics and clinical course of patients with COVID-19 who received invasive mechanical ventilation in Osaka, Japan	Hirayama,  A,  Masui, et al	International Journal of Infectious Diseases	Epidemiology| Épidémiologie Clinical data| Données cliniques	Objective: To describe the detailed clinical course of patients with coronavirus disease 2019 (COVID-19) who received invasive mechanical ventilation. Results: Overall, the 30-day mortality was 24.0%, and the median length of ICU stay and length of invasive mechanical ventilation use were 16 days and 13 days, respectively. In multivariable logistic regression analysis, age of 65 years or older and male sex were significantly associated with a higher 30-day mortality rate.
Health Economic Aspects of the Corona Crisis in Switzerland: Results from the COVID-19 Social Monitor	Höglinger,  M,  Brunner, et al	Gesundheitsokonomie und Qualitatsmanagement	Healthcare Response | Réponse des soins de santé	After the outbreak of the Corona pandemic, Switzerland went into a national lockdown in March. This had a large impact on social life and health care. The COVID-19 Social Monitor shows some of the societal changes during and after the period of the lockdown. The results show that in the acute phase of the lockdown, between about 50 % (General practitioners) and over 90 % (dentists) of the medical consultations were not consumed. Moreover, the general work productivity decreased severely; during the full lockdown, average productivity losses amounted to 46 %. With the lifting of the lockdown measures from the end of April, the situation largely normalized.
Whole Genome Sequencing for Revealing the Point Mutations of SARS-CoV-2 Genome in Bangladeshi Isolates and their Structural Effects on Viral Proteins	Hossain,  Mohammad Uzzal,  Ahammad, et al	bioRxiv	Coronavirology| Coronavirologie	this study, we performed complete genome sequencing of SARS-CoV-2 to unveil the genomic variation and indel, if present. We discovered thirteen (13) mutations in Orf1ab, S and N gene where seven (7) of them turned out to be novel mutations from our sequenced isolate. Besides, we found one (1) insertion and seven (7) deletions from the indel analysis among the 323 Bangladeshi isolates. Our analysis also suggested that eleven (11) mutations could exert damaging effects on their corresponding protein structures.
Network of “drug-target-SARS-CoV-2 Related Genes” Through Integrated Analysis of Pharmacology and Geo Database	Hou,  Jin ping,  Wang, et al	Research Square prepub	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	This paper integrates network pharmacology and GEO database to mine and identify COVID-19 molecular therapeutic targets, providing potential targets and new ideas for COVID-19 gene therapy and new drug development. Combining drug target genes in pharmacology database and virus induced genes in GEO database, the result showed the core hub genes related to COVID-19: STAT1, IL1B, IL6, IL8, PTGS2 and NFKBIA, and these genes were significantly downregulated in A549 and NHBE cells by SARS-CoV-2 infection. Moreover, chemical interaction and molecular docking analysis of hub genes showed that folic acid might as be potential therapeutic drug for COVID-19 treatment, and SARS-CoV-2 nucleocapsid phosphoprotein was a potential drug target.
Factors for peripherally inserted central catheters care delay in cancer patients during the covid-19 pandemic	Hu,  L,  Tao, et al	Annals of Palliative Medicine	Healthcare Response | Réponse des soins de santé	We studied 156 cancer patients with PICCs treated at the Cancer Center of the Fifth Affiliated Hospital of Sun Yat-sen University between January 2020 and March 2020. Results: Of 156 patients, 57 (36.5%) experienced delays of PICCs care, and 12 (21.1%) suffered from complications including infection, thrombosis, and mechanical failure. Univariate analysis detected that the increased risk of PICCs care delay was associated with older age (≥30), lower level of education (<9 years), working, taking public transport to the hospital, anxiety about COVID-19, lower social support rating scale (SSRS) score (<30).
Comparative Analysis of Nanomechanical Features of Coronavirus Spike Proteins and Correlation with Lethality and Infection Rate	Hu,  Y,  Buehler, et al	Matter	Coronavirology| Coronavirologie	Our analysis shows that epidemiological virus properties can potentially be linked directly to pure nanomechanical, vibrational aspects, offering an alternative way of screening new viruses and mutations, and perhaps even novel ways to prevent infections from occurring. We provide a novel way toward understanding coronavirus spike proteins, connecting their nanomechanical features (specifically their vibrational spectrum and quantitative measures of mobility) with virus lethality and infection rate. Our study shows that the nanomechanics of proteins, captured in their continuous motions, can be a useful tool to help us understand complex disease etiology by connecting nanoscopic physical features with epidemiological data.
Enhancement of the IFN-β-induced host signature informs repurposed drugs for COVID-19	Huang,  CT,  Chao, et al	Heliyon	Therapeutics| Thérapeutique	We experimentally confirmed that the predicted compounds significantly inhibited SARS-CoV-2 replication in Vero E6 cells at nanomolar, relatively non-toxic concentrations, with half-maximal inhibitory concentrations of 165.7 nM, 16.5 nM, and 31.4 nM for homoharringtonine, narciclasine, and anisomycin, respectively.
Online alcohol delivery is associated with heavier drinking during the first New Zealand COVID-19 pandemic restrictions	Huckle,  T,  Parker, et al	Drug and Alcohol Review	Public Health response| Interventions de santé publique	This paper aimed to assess purchasing and drinking behaviour during the first COVID-19 pandemic restrictions in New Zealand. During pandemic restrictions, around 75% of respondents purchased from supermarkets, 40% used online alcohol delivery services (18% for the first time during COVID-19). Purchasing online alcohol delivery during pandemic restrictions was associated with heavier drinking (75% higher odds) in the past week, while purchasing from supermarkets was not.
COVID-19 in a collectivist culture: social isolation and maintenance of social relations	Hussein,  NH	International Journal of Sociology and Social Policy	Public Health response| Interventions de santé publique	In light of the paucity of research carried out on COVID-19, the present research provides a pioneering insight into the meaning of social isolation in a collectivist culture and the distinctive local methods adopted by people to maintain their networks of social relations.
Diagnosis clinical features in patients infected with novel COVID-19 in Iraq	Hussein,  SM,  Kubba, et al	European Journal of Molecular and Clinical Medicine	Clinical data| Données cliniques	The results showed that the total number of monocyte, hemoglobin (Hb)and red blood cell were slightly decrease or remained normal, while 90% of patients presented the number of leukocytes were highly increased and the percentage of lymphocytes were reduced, platelets count increased in 80 % and the serum CRP was slightly to high increased, except 10 % of patients slightly increase in leukocyte platelets, moderate change in the percentage of lymphocyte and 20% of serum CRP still normal.
Performance of three automated SARS-CoV-2 antibody assays and relevance of orthogonal testing algorithms	Huyghe,  E,  Jansens, et al	Clinical Chemistry and Laboratory Medicine	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Diagnostic specificity (ability to detect a COVID-19 negative patient) was 95.0% (95% CI 89.4-98.1%) for DiaSorin, 99.2% (95% CI 95.4-99.9%) for Roche and 100% (95% CI 97.0-100%) for Siemens. The sensitivity/specificity for detecting antibodies (ability of detecting absence (specificity) or presence (sensitivity) of COVID-19 antibodies) was 92.4% (95% CI 86.4-96.3%)/94.9% (95% CI 90.5-97.6%) for DiaSorin, 97.7% (95% CI 93.5-99.5%)/97.1% (95% CI 93.5-99.1%) for Roche and 98.5% (95% CI 94.6-99.8)/97.1 (95% CI 93.5-99.1%) for Siemens.
SDL Cellular Automaton COVID-19 conceptualization	i Casas,  PF,  de Barcellos, et al		Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	In this paper, we present a conceptualization of the COVID-19 pandemic situation. The model represented in Specification and Description Language allows a detailed parametrization of the pandemic situation and a further expansion of an initial model defined using the System Dynamics approach to Cellular Automaton approach.
Left Ventricular Thrombus With COVID-19 Complication in a Patient With Dilated Cardiomyopathy	Imaeda,  S,  Kabata, et al	CJC Open	Clinical data| Données cliniques	Here, we describe a case of non-severe COVID-19 in a patient with dilated cardiomyopathy. After admission, symptoms, laboratory data, and imaging findings improved, but D-dimer levels gradually increased. Contrast computed tomography and echocardiography revealed a left ventricular thrombus. Anticoagulant treatment diminished the thrombus, and the patient recovered and was discharged.
Intra-host non-synonymous diversity at a neutralizing antibody epitope of SARS-CoV-2 spike protein N-terminal domain	Ip,  JD,  Kok, et al	Clinical Microbiology and Infection	Coronavirology| Coronavirologie	SARS-CoV-2 has evolved rapidly into several genetic clusters.  A spike protein amino acid mutation W152L located within a neutralizing epitope has appeared naturally in a patient. Our study demonstrated that monitoring of serial specimens is important in identifying hotspots of mutations, especially those occurring at neutralizing epitopes which may affect the therapeutic efficacy of monoclonal antibodies.
Perception and Attitudes Toward PPE-Related Waste Disposal Amid COVID-19 in Bangladesh: An Exploratory Study	Islam,  SMDU,  Safiq, et al	Frontiers in Public Health	Public Health response| Interventions de santé publique	There is no prior study investigating public perception and attitudes toward PPE-related waste disposal in Bangladesh. Hence, an online survey was carried out among 1,303 Bangladeshi adult residents to explore the issue. Results stated that face mask and hand gloves were the widely used PPE, where around 45.50% mask and 31.60% hand gloves were disposable. Approximately 94.50% of the participants percepted to use at least one type of PPE while going outside. Only 18.65% of the respondents percepted to burn the PPE-related waste, while most of them reported other less protective disposal measures. Females, urban residents, and participants with higher education were found to have better perception and attitudes toward PPE-related waste disposal.
Assessing COVID-19 related knowledge and perceptions of preventive health care employees working in health region Kalmunai-Sri Lanka	Issadeen,  S,  Aboobucker, et al	European Journal of Molecular and Clinical Medicine	Healthcare Response | Réponse des soins de santé	This study aimed to investigate the knowledge and perceptions of Preventive health care Employees about COVID-19.A cross-sectional, study was conducted during June and July 2020, midst of COVID-19 outbreak in the country. A chi-square test was applied to investigate the level of association among variables, with significance set to P57.62%) and positive perception (>69.01%) and Medical officers and Public Health Inspectors scored more than Public Health Midwife.
Adjusting RT-qPCR conditions to avoid unspecific amplification in SARS-CoV-2 diagnosis	Jaeger,  LH,  Nascimento, et al	International Journal of Infectious Diseases	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Here we report dimer formation in the N2 primers–probe set (CDC 2019-nCoV Real-Time RT-PCR) used in the diagnostic routine, and propose alternatives to reduce dimerization events. Late unspecific amplifications were visualized in 56.4% of negative samples and 57.1% of no-template control, but not in positive samples or positive control. In silico analysis and gel electrophoresis confirmed the dimer formation. The RT-qPCR parameters were optimized and the late unspecific amplifications decreased to 11.5% in negative samples and no-template control. The adjustment of PCR parameters was essential to reduce the risk of false-positives results and to avoid inclusive results requiring repeat testing, which increases the costs and generates delays in results or even unnecessary requests for new samples.
PMC7680083; A Unique Feature of COVID-19 Infection in Chest CT; "Pulmonary Target" Appearance	Jafari,  R,  Maghsoudi, et al	Acad Radiol	Clinical data| Données cliniques	We present a unique imaging feature of pulmonary involvement in four RT-PCR proven COVID-19 cases. A circular appearance of noninvolved pulmonary parenchyma with a central hyperdense dot surrounded by ground glass or alveolar opacities was found in each of them. Chest CT of four following cases showed bilateral multifocal patchy consolidative opacities, which were nonspecific common suggestive findings for COVID-19 infection
Analysis of the potential impact of genomic variants in global SARS-CoV-2 genomes on molecular diagnostic assays	Jain,  A,  Rophina, et al	International Journal of Infectious Diseases	Coronavirology| Coronavirologie Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Our analysis revealed that a total of 5862 unique genetic variants mapped to at least one of the 132 primer or probe binding sites in the genome. A total of 29 unique variants were present in ≥ 1% of genomes from at least one of the continents (Asia, Africa, Australia, Europe, North America, and South America) that mapped to 36 unique primers or probes binding sites. Similarly, a total of 27 primer or probe binding sites had cumulative variants frequency of ≥ 1% in the global SARS-CoV-2 genomes. We also found 286 SARS-CoV-2 genomic regions with low variability at a continuous stretch of ≥ 20bps that could be potentially used for primer designing
In silico evaluation of flavonoids as effective antiviral agents on the spike glycoprotein of SARS-CoV-2	Jain,  AS,  Sushma, et al	Saudi Journal of Biological Sciences	Therapeutics| Thérapeutique	In the current study, an in silico approach is carried out as a means of inhibiting the spike protein of the novel coronavirus by flavonoids from natural sources that possess both antiviral and anti-inflammatory properties.  The flavonoid naringin showed the least binding energy of −9.8 Kcal/mol with the spike protein which was compared with the standard drug, dexamethasone which is being repurposed to treat critically ill patients. MD simulation was carried out on naringin-spike protein complex for their conformational stability in the active site of the novel coronavirus spike protein.
Therapeutic plasma exchange followed by convalescent plasma transfusion in critical COVID-19—An exploratory study	Jaiswal,  V,  Nasa, et al	International Journal of Infectious Diseases	Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique	We undertook this exploratory study to evaluate safety and efficacy of TPE followed by CP transfusion in 14 patients with critical COVID-19 requiring invasive mechanical ventilation (IMV). All patients showed improvement in symptoms and decrease of inflammatory markers especially CRP (p = 0.03). 10 patients were liberated from IMV after a median of 5.5 (3–36) days, post sequential therapy. No patient developed transfusion-associated complications, but three patients developed secondary bacterial sepsis within 14 days of therapy, and one died. This case series demonstrated the sequential use of TPE followed by CP transfusion as a therapeutic option in critical COVID-19.
What is the source and origin of covid 19 -a survey on popular perception	Jalan,  S,  Lakshmanan, et al	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	The study aims at analyzing the public perception on the source and origin of COVID- 19 and to spread its awareness among citizens. A questionnaire was distributed through an online google forms link to about 100 people. From the results analysed from the responses of the study population, the majority of the participants gave a positive response and awareness about the source and origin of COVID-19. This study gives an insight on the public perception towards the source and origin of covid 19.
Is India capable of managing pandemic- a survey on popular perception among Indians	Jayadharani,  C,  Sekar, et al	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	From the results, the majority of the study population answered positive responses regarding India's capability of managing pandemic and also awareness of Pandemic among people of India.. 100% of the population were aware of the pandemic and its outbreaks. This study gives an insight on the popular perception toward India's capability of managing pandemic, and creating an awareness on its spread.
Early, low-dose, short-term methylprednisolone decreased the mortality in critical COVID-19 patients: A multicenter retrospective cohort study	Ji,  J,  Wu, et al	Journal of Infection	Therapeutics| Thérapeutique	Present multicenter retrospective cohort study showed that methylprednisolone therapy could decrease the 60-fatality for the COVID-19 patients diagnosed as critical type, that is, those occurred respiratory failure and needs mechanical ventilation, or shock, or multiple organ failure and needs ICU monitoring. Early (starting in 7 days after admission), low-dose (no more than 80 mg/d), and short-term (no more than 7 days) methylprednisolone therapy could significant decrease the 60-day fatality.
Young people, mental health and COVID-19 infection: the canaries we put in the coal mine	Jia,  R,  Ayling, et al	Public health	Mental Health | santé mentale	We report here on the mental health of young adults and related psychological and behavioural responses to the pandemic and consider the role of these factors in fuelling the increase in coronavirus disease 2019 (COVID-19) in this group. We contend that the combination of mental health, social and economic considerations may have contributed to the rise of COVID-19 infections in young adults, and ascribing blame to this group will not aid our efforts to regain control of the disease.
Autopsy and Statistical Evidence of Disturbed Hemostasis Progress in COVID-19: Medical Records from 407 Patients	Jiang,  Tiebin,  Lv, et al	Research Square prepub	Clinical data| Données cliniques	At the beginning of hospitalization, platelet (PLT) counts were significantly reduced in critically ill patients compared with severely or mildly ill patients. Blood glucose (GLU), prothrombin time (PT), activated partial thromboplastin time (APTT), and D-dimer levels in critical patients were increased compared with mild and severe patients during the entire admission period. In the relatively late stage of nonsurvivors, the temporal changes in PLT count, PT, and D-dimer levels were significantly different from those in survivors. utopsy data from 9 deceased patients also revealed DIC phenomena with prolonged PT, APTT, lower PLT count and thrombosis in multiple organs.
Cause analysis and enlightens of hand injury during the COVID-19 outbreak and work resumption period	Jin,  Qianjun,  Zhou, et al	Research Square prepub	Healthcare Response | Réponse des soins de santé	The number of total emergency visits due to hand injury during the COVID-19 outbreak decreased 37% when compared to the same period in the previous year. At the same time, work resumption injuries increased 40%. In comparison to the corresponding period in the previous year, most injured patients during the COVID-19 outbreak were women (60%) with a mean age of 56.7, while during the work resumption stage, most were men (82.4%) with a mean age of 44.8. The majority of injuries within the resumption period occurred at work (64.7%), significantly more than in the same period in 2019 (37.3%) (P < 0.001). Machine injuries were the most frequent (58.8%). Data show that different degrees of cutting injuries comprised the majority of total cases (82.4%), far more than simple fractures and dislocations, with fingers the most commonly injured body part. The majority of injuries were classified as either minor or moderate (90%) during the outbreak while major (40%) during the resumption of work. The proportion of major injuries during the work resumption stage in this year (40%) have been almost double that of the previous year (pre-pandemic) (21.8%) (P = 0.006)
COVID-19 Trends in Florida K-12 Schools, August 10 – November 14, 2020	Jones,  RebekahD	medRxiv	Epidemiology| Épidémiologie Transmission	Florida schools began reopening to in-person instruction in August have reported more than 18,000 student and staff cases of COVID-19 as of November 14, 2020. Incidence of COVID-19 cases in K-12 students and staff is of urgent public health concern. COVID-19 cases reported in Florida schools were most influenced by community case rates, district mask policies, and percent of students attending face-to-face. Student case rates were highest in high schools (12.5 per 1,000).
Perception of health and educational risks amongst dental students and educators in the era of COVID-19	Jum’ah,  AA,  Elsalem, et al	European Journal of Dental Education	Healthcare Response | Réponse des soins de santé	To investigate the perceived educational and health risks associated with the COVID-19 pandemic amongst dental students and educators. The recent COVID-19 outbreak has adversely affected various elements of dental education. High levels of major health risk perception were noted amongst students and educators. The interruption to academic and clinical activities may lead to an inevitable skill deficit within the new generation of dental graduates. Educators are under significant pressure to accommodate abrupt changes in teaching methods, find solutions to mitigate skill deficit and ensure safe clinical practice once clinical activities are resumed.
Online biophysical predictions for SARS-CoV-2 proteins	Kagami,  Luciano,  Martinez, et al	bioRxiv	Coronavirology| Coronavirologie	We here present a website (http://sars2.bio2byte.be/) that provides protein sequence-based predictions of the backbone and side-chain dynamics and conformational propensities of these proteins, as well as derived early folding, disorder, β-sheet aggregation and protein-protein interaction propensities. These predictions attempt to capture the 'emergent' properties of the proteins, so the inherent biophysical propensities encoded in the sequence, rather than context-dependent behaviour such as the final folded state.
Plausible mechanisms explaining the role of cucurbitacins as potential therapeutic drugs against coronavirus 2019	Kapoor,  N,  Ghorai, et al	Informatics in Medicine Unlocked	Therapeutics| Thérapeutique	Sixteen cucurbitacin analogues were investigated for activity against the SARS-CoV-2 main protease protein (Mpro), angiotensin-converting enzyme 2 (ACE2) binding receptor, nonstructural protein 12 (NSP12) RNA-dependent RNA polymerase (RdRp), NSP13 helicase, and Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway using several relevant tools and simulated screening methods. All key proteins were found to bind efficiently only with cucurbitacin G 2-glucoside and cucurbitacin H with the lowest global energy.
Impact of COVID-19 outbreak on plastic surgery: Taken precautions, distribution of surgical procedures and changes in admissions to outpatient clinic	Kara,  M,  Akduman, et al	Journal of Plastic, Reconstructive and Aesthetic Surgery	Healthcare Response | Réponse des soins de santé	The present study aims to analyze the effect of the COVID-19 pandemic on plastic surgery practice in some aspects. While the number of outpatient clinic patients was 3511 in the routine period, it was 490 in the pandemic period. Compared to the routine period, the number of surgical interventions was decreased from 793 to 129 during the pandemic period. In particular, a statistically significant increase was observed in the rate of hand trauma and maxillofacial trauma cases during the pandemic period compared with the routine period (p < 0.001, and p = 0.032, respectively).
Determinants of COVID-19 Incidence and Mortality in the US: Spatial Analysis	Kathe,  Niranjan,  Wani, et al	medRxiv	Epidemiology| Épidémiologie	The objective of this study was to assess the ecological determinants (policy, health behaviors, socio-economic, physical environment and clinical care) of COVID-19 incidence and mortality. ounties with higher proportions of republican voters, and racial minorities (African Americans, Native Americans and Hispanics), those not proficient in English, and higher population density, pollution-particulate matter, residential segregation between non-Whites & Whites were associated with high incidence rates. Subsequently, counties with higher republican voters, excessive drinkers, children in single-parent households, uninsured adults, racial minorities, females, and high population density, pollution-particulate matter, and residential segregation between non-Whites & Whites was associated with high COVID-19 mortality rates.
A Case Study of Dual Infection of Dengue and COVID-19: Presenting as Multiorgan Dysfunction in an Infant	Kazi,  MA,  Ghosh, et al	J Trop Pediatr	Clinical data| Données cliniques	Here, we present one such case of a 9-month-old female child who tested positive for dengue as well as COVID-19 during the ongoing corona pandemic and went on to develop shock, encephalopathy with deranged liver enzymes but managed to overcome all odds and recover from the disease by day 14 of illness.
Emotional Responses and Perceived Stressors of Front-Line Medical Staffs in Case of Addis Ababa COVID-19 Treatment Centers and Obstetrics Emergency and Abortion Care Clinic, Ethiopia; Analytical Cross Sectional Study	Kebede,  Mebratu Abraha,  Demissie, et al	SSRN- Lancet prepublication	Mental Health | santé mentale	The aim of this study will be to assess the current state of emotional responses and perceived stressors of frontline medical staffs in case of Addis Ababa COVID-19 Treatment Centers and obstetrics emergency and abortion care, Ethiopia 2020. This study revealed that, 72.9% and 5.6% of the study participant from obstetrics emergency and abortion clinic and COVID-19 treatment centers had a positive emotional response, respectively. Factors such as having a low level of motivational factors (AOR 2.78, 95% CI (1.13, 6.84)), being a nurse (AOR 10.53, 95% CI (1.31, 85.26)) and working at triage (AOR 8.61, 95% CI (1.15, 64.81))) had statistically significant association with negative emotional response.
Relationship of Quality of Life, Resilience, and Associated Factors Among Nursing Faculty During COVID-19	Keener,  TA,  Hall, et al	Nurse Educ	Mental Health | santé mentale	The purpose of this study was to examine the relationship of QoL, resilience, and associated factors among nursing faculty during the COVID-19 pandemic. Resilience was the strongest variable to predict each of the QoL domains. Nursing faculty who reported better QoL were those who were able to adapt to changes and challenges mandated during the COVID-19 pandemic.
Chloroquine as a prophylactic agent for covid-19 infection - a survey among south Indian population	Keerthana,  B,  Gayatri Devi, et al	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	A self-administered questionnaire was prepared consisting of 10 questions and was distributed to a random population through Google docs and we got almost 100 responses. About 63% of the participants are aware of COVID-19 and chloroquine. About 50% of the participants' perception is that chloroquine will protect them from COVID-19, and are aware that hydroxychloroquine and other forms of chloroquine are undergoing a clinical trial of COVID-19.
Anxiety among young adults and the elderly during the lockdown for SARS-CoV2	Kettani,  Z	NPG Neurologie - Psychiatrie - Geriatrie	Mental Health | santé mentale	In this study, we set out to assess levels of anxiety via somatization among the participants in order to highlight any differences between anxiety among young adults and anxiety among the elderly. The participants were men and women who were subjected to lockdown in Morocco during the SARS-CoV2 pandemic. We found that young adults exhibited more intense anxiety than the elderly during this period of confinement and that the elderly subjects were more likely to experience so-called “normal” anxiety following the COVID-19 pandemic.
Ca2+-dependent mechanism of membrane insertion and destabilization by the SARS-CoV-2 fusion peptide	Khelashvili,  George,  Plante, et al	bioRxiv	Coronavirology| Coronavirologie	We have identified the preferred positions of Ca2+ binding to the SARS-CoV-2-FP, the role of Ca2+ ions in mediating peptide-membrane interactions, the preferred mode of insertion of the Ca2+-bound SARS-CoV-2-FP and consequent effects on the lipid bilayer from extensive atomistic molecular dynamics (MD) simulations and trajectory analyses. Findings provide novel mechanistic insights regarding the role of Ca2+ in mediating SARS-CoV-2 fusion and provide a detailed structural platform to aid the ongoing efforts in rational design of compounds to inhibit SARS-CoV-2 cell entry.
Improved convolution neural network for detecting Covid-19 from X-ray images	Kota,  SSS,  Reddy, et al	European Journal of Molecular and Clinical Medicine	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	This work introduces a new paradigm for automatic detection of COVID-19 using raw X-ray images in the chest. The proposed model with 4 Convolutional Layers, 2 Max Pooling Layers and Drop Outs, is designed to provide reliable diagnostics for binary (COVID vs. No-Findings) and multi-class (COVID vs. No-Findings vs. Pneumonia) diagnosis. Our model provided gives 98.9% Binary Classification accuracy and 85% Multi Classification accuracy.
Household transmission and incidence of positive SARS-CoV-2 RT-PCR in symptomatic healthcare workers, clinical course and outcome: a French hospital experience	Krastinova,  E,  Garrait, et al	Occup Environ Med	Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques	In this study, we investigated infection rates, clinical characteristics, occupational exposure and household transmission among all symptomatic HCWs screened by SARS-CoV-2 RT-PCR between 17 March (French lockdown) and 20 April.  The incidence rate of symptomatic SARS-CoV-2 was estimated to be 5% (110/2188). A total of 110 (35%) of the 314 HCWs tested positive and 9 (8%) were hospitalised. On multivariate analysis, factors independently associated with positive RT-PCR were occupational profile with direct patient facing (OR 3.1, 95% CI 1.1 to 8.8), p<0.03), and presence of anosmia (OR 5.7, 95% CI 3.1 to 10.6), p<0.0001). Being a current smoker was associated with negative RT-PCR (OR 0.3, 95% CI 0.1 to 0.7), p=0.005). Transmission from HCWs to household members was reported in 9 (14%) cases, and 2 deaths occurred.
PMC7716110; The effect of national lockdown due to COVID-19 on emergency department visits	Kuitunen,  I,  Ponkilainen, et al	Scand J Trauma Resusc Emerg Med	Healthcare Response | Réponse des soins de santé	Our aim is to describe the effect of national lockdown and social distancing on the number and reasons for emergency department (ED) visits and inpatient admissions in three large volume hospitals prior to and after the outbreak of the COVID-19 epidemic in Finland. The total number of ED visits decreased 16% after the lockdown, whereas the number of inpatient admissions decreased 15% (p < 0.001).  The visit rate and inpatient admissions due to acute myocardial infarction and strokes remained stable throughout the study period. Interestingly, the rate of inpatient admissions due to psychiatric diagnoses remained unchanged, although the ED visit rate decreased by 19%. The number of ED visits (n = 282) and inpatient admissions (n = 55) due to COVID-19 remained low in the participating hospitals.
Rural community awareness levels, challenges and strategies adopted to combat covid-19: A cross-sectional e-survey	Kumar Srivastav,  A,  Sharma, et al	Revista Pesquisa em Fisioterapia	Public Health response| Interventions de santé publique	The objective of this study is to identifyi the level of awareness and challenges faced by the people of rural communities in India due to the COVID-19 outbreak. A total of 94% (n=25) of villagers were aware of COVID-19, 88% (n=24) were facing challenges, and 86% (n=23) of participants are adopting the best strategies which includes, sealing of containment zone, usage of homemade mask made up of clothes, consuming traditional herbal medicine as immunity boosters for prophylaxis and involving in regular physical activity and yoga.
Do the Moroccan SARS-Cov-2 genetic diversity hamper the use of the developed universal vaccines in Morocco?	Laamarti,  Meriem,  Essabbar, et al	bioRxiv	Epidemiology| Épidémiologie Coronavirology| Coronavirologie	The present study aims to analyze and identify the genetic variants of forty-eight Moroccan strains of SARS-CoV-2 collected from mid-March to the end of May and the prediction of their possible sources. Our results revealed 108 mutations in Moroccan SARS-CoV-2, 50% were non-synonymous were present in seven genes (S, M, N, E, ORF1ab, ORF3a, and ORF8) with variable frequencies. Remarkably, eight non-synonymous mutations were predicted to have a deleterious effect for (ORF1ab, ORF3a , and the N protein. The analysis of the haplotype network of Moroccan strains suggests different sources of SARS-CoV-2 infection in Morocco. Likewise, the phylogenetic analysis revealed that these Moroccan strains were closely related to those belonging to the five continents, indicating no specific strain dominating in Morocco.
Telehealth sustains patient engagement in OUD treatment during COVID-19	Langabeer,  JR, , et al	Journal of substance abuse treatment	Healthcare Response | Réponse des soins de santé	The objective of this study was to outline our organizational telehealth adaptations that enabled virtual counseling, peer support, groups, and provider care during COVID-19 in one community-based opioid treatment program. After we closed our facility for the first five business days, we rapidly enacted virtual care with telehealth for peer coaching, counseling, groups, and provider visits. While we lost patient volume during the initial weeks, we observed an overall increase in patient engagement over time.
An Unusual Case of COVID-19 Presenting as Acute Psychosis	Lanier,  CG,  Lewis, et al	J Pharm Pract	Clinical data| Données cliniques Mental Health | santé mentale	Case report of a  58 year-old male presented with acute psychosis and no symptoms associated with COVID-19. He denied fever, chills, chest pain, shortness of breath, or gastrointestinal symptoms. Patient was confused, disruptive, unable to communicate, and admitted to hallucinations.
Migration, externalities, and the diffusion of COVID-19 in South Asia☆	Lee,  JN,  Mahmud, et al	Journal of Public Economics	Epidemiology| Épidémiologie	We investigate the relationship between migrant movements and the spread of COVID-19 using district-day-level data from Bangladesh, India, and Pakistan (the 1st, 6th, and 7th largest sources of international migrant workers). We find that during the initial stage of the pandemic, a 1 SD increase in prior international out-migration relative to the district-wise average in India and Pakistan predicts a 48% increase in the number of cases per capita. In Bangladesh, however, the estimates are not statistically distinguishable from zero. Domestic out-migration predicts COVID-19 diffusion in India, but not in Bangladesh and Pakistan. In all three countries, the association of COVID-19 cases per capita and measures of international out-migration increases over time.
Clinical Evaluation of a COVID-19 Antibody Lateral Flow Assay using Point of Care Samples	Lee,  Won,  Straube, et al	medRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The aim of this study was to assess the performance of a lateral flow immunoassay (Humasis® COVID-19 IgG/IgM) for the detection of SARS-CoV-2 antibodies using samples collected at point of care (PoC). The sensitivity for IgM and IgG detection >14 days after date of onset was 88% (95% CI: 68.8% - 97.5%) and 84% (95% CI: 63.9% - 95.5%.) The overall specificity was 94% (95% CI: 83.5% - 98.8%). The Immunoglobulin specific specificity was 94% for IgM (95% CI: 83.5% - 98.8%) and 98% for IgG (95% CI: 89.4% - 100.0%).
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2	Lei,  Yuyang,  Zhang, et al	bioRxiv	Coronavirology| Coronavirologie	We show here that S protein of SARS-CoV-2 alone can damage vascular endothelial cells (ECs) in vitro and in vivo, manifested by impaired mitochondrial function, decreased ACE2 expression and eNOS activity, and increased glycolysis. The underlying mechanism involves S protein downregulation of AMPK and upregulation of MDM2, causing ACE2 destabilization. Thus, the S protein-exerted vascular endothelial damage via ACE2 downregulation overrides the decreased virus infectivity.
Longitudinal lab test analysis confirms pre-existing anemia as a severe risk factor for post-viral clearance hospitalization in COVID-19 patients	Lenehan,  Patrick,  Ramudu, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	Here, we analyzed longitudinal lab testing data from a previous patient cohort to determine whether anemia and acute kidney injury measurements corroborate our notes-derived findings. Indeed we found that COVID-19 patients hospitalized after confirmed viral clearance tended to have lower hemoglobin and hematocrit measurements both during their SARS-CoV-2 positive intervals and during the one year prior to COVID-19 diagnosis compared to patients who have not been rehospitalized after viral clearance. Further, outright laboratory-based diagnosis of moderate or severe anemia was strongly enriched in the hospitalized cohort, suggesting that anemia pre-dating or concurrent with SARS-CoV-2 infection may predispose patients to long-term complications of COVID-19.
Characteristics and Timing of Initial Virus Shedding in Severe Acute Respiratory Syndrome Coronavirus 2, Utah, USA	Lewis,  NM,  Duca, et al	Emerg Infect Dis	Epidemiology| Épidémiologie Transmission	We investigated household transmission of COVID-19 in 5 households with daily specimen collection for 5 consecutive days starting a median of 4 days after symptom onset in index patients. Seven contacts across 2 households implementing no precautionary measures were infected. Of these 7, 2 tested positive for SARS-CoV-2 by reverse transcription PCR on day 3 of 5. Both had mild, nonspecific symptoms for 1–3 days preceding the first positive test. SARS-CoV-2 was cultured from the fourth-day specimen in 1 patient and from the fourth- and fifth-day specimens in the other. We also describe infection control measures taken in the households that had no transmission.
Safety and efficacy of artemisinin-piperaquine for treatment of COVID-19: an open-label, non-randomised and controlled trial	Li,  G,  Yuan, et al	International journal of antimicrobial agents	Therapeutics| Thérapeutique	This reports investigated the saftey and efficacy of Artemisinin-piperaquine (AP) in an open-label, non-randomized controlled trial (n= 41). Results indicate that in patients with mild-to-moderate COVID-19, the time to reach undetectable SARS-CoV-2 was significantly shorter in the AP group than that in the control group.
Evaluation of low-dose CT protocol of novel coronavirus pneumonia based on infection prevention and control	Li,  H,  Ning, et al	Chinese Journal of Radiological Medicine and Protection	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The  objective of this study was to explore if a low dose CT scan would meet the image quality needs for patients with COVID-19. The patients in low dose group(120 kV, 31 mAs) consisted of mild type(51), severe type(15) and critically ill type(4); and those in conventional dose group(120 kv, adaptive milliampere second) consisted of mild type(48), severe type(17) and critically ill type(5). The effective radiation dose, SNR and CNR of CT scan were compared between two groups. A senior and a middle radiologist made the image subjective quality scores, respectively. Results find that the effective dose in low dose group was lower than that of conventional dose group (t=-48.343, P0.05). For severe and critically ill patients, the score in low dose group was significantly lower than that in conventional dose group(t=-2.781, P0.05).
Multiscale Attention Guided Network for COVID-19 Detection Using Chest X-ray Images	Li,  Jingxiong,  Wang, et al	arXiv	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Multiscale Attention Guided deep network with Soft Distance regularization (MAG-SD) is proposed to automatically classify COVID-19 from pneumonia chest X-ray (CXR) images. In MAG-SD, MA-Net is used to produce prediction vector and attention map from multiscale feature maps. To relieve the shortage of training data, attention guided augmentations along with a soft distance regularization are posed, which requires a few labeled data to generate meaningful augmentations and reduce noise. Our multiscale attention model achieves better classification performance on our pneumonia CXR image dataset.
Knowledge and Perceptions of the COVID-19 Pandemic Among Patients with Myasthenia Gravis	Li,  Y,  Emmett, et al	Muscle Nerve	Public Health response| Interventions de santé publique	Our goal is to understand how patients with myasthenia gravis (MG) are experiencing the COVID‐19 pandemic, including where they receive relevant information, how it has affected medical care, and what measures they use to protect themselves. 1,848 patients were approached to participate and 75 completed the survey between April 16, 2020 and May 28, 2020. The most frequently used information sources were non‐presidential federal government (75%), state government (57%), local healthcare provider (37%), and television news (36%). Non‐presidential federal government (80%), local healthcare providers (55%), state government (33%) and patient support organizations (29%) were considered the most trusted information sources. Thirty‐three (44%) of survey responders had attended a telemedicine visit. Patients were taking recommended precautions during the pandemic and remained very concerned (69%) about COVID‐19. Generalized Anxiety Disorder‐7 scores were moderate‐severe in 20% of responders.
Mental Health Among College Students During the COVID-19 Pandemic in China: A 2-Wave Longitudinal Survey	Li,  Y,  Zhao, et al	Journal of affective disorders	Mental Health | santé mentale	This study is a  large-scale, longitudinal, population-based survey was conducted among college students in China that was conducted to investigate longitudinal course of psychopathology in young adults at different stages of the pandemic. Resuls find that senior students, with suspected or conformed cases in their community and COVID-19 related worries (all AORs > 1.20, ps < 0.001) were found to have a higher risk of developing mental health problems in at least one wave. Less physical exercise, low perceived social support, and a dysfunctional family were found to negatively impact psychological symptoms.
Association of inhaled and systemic corticosteroid use with Coronavirus Disease 2019 (COVID-19) test positivity in patients with chronic pulmonary diseases	Liao,  SY,  Petrache, et al	Respiratory medicine	Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique	We aim to study if the use of inhaled or systemic corticosteroids affects the likelihood of developing COVID-19 infection. The cohort consisted of 928 patients, of which 12% tested positive. The majority (66%) of patients had a history of chronic pulmonary diseases. There was no significant association between inhaled corticosteroid use and testing positive for COVID-19. Interestingly, systemic corticosteroid use was associated with a lower odds ratio (0.95, 95% CI: 0.91–0.99) of testing positive for COVID-19. Similar results were noted when the analysis was restricted to those with any chronic pulmonary diseases, with asthma or with chronic obstructive pulmonary disease (COPD).
Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study	Lima-Setta,  F,  Magalhães-Barbosa, et al	Jornal de pediatria	Clinical data| Données cliniques	The objective of this multi-center prospective cohort study was to describe the clinical, laboratory, and radiological characteristics, as well as the outcomes of children with MIS-C. Fifty-six patients were included, with the following conditions: Kawasaki-like disease (n = 26), incomplete Kawasaki disease (n = 16), acute cardiac dysfunction (n = 10), toxic shock syndrome (n = 3), and macrophage activation syndrome (n = 1). Median age was 6.2 years (IQR 2.4−10.3), 70% were boys, 59% were non-whites, 20% had comorbidities, 48% reported a contact with COVID-19 cases, and 55% had a recent SARS-CoV-2 infection confirmed by RT-PCR and/or serology. Overall, most characteristics of the present MIS-C patients were similar to that of other cohorts.
Perinatal transmission of SARS-CoV-2: Need of study by possible congenital infection	Limay-Ríos,  O,  Dávila-Aliaga, et al	Revista colombiana de obstetricia y ginecologia	Clinical data| Données cliniques	Case report of a newborn with a postive test on day 2 of life. that was unable to ruled out as a possible infection congenital, intrapartum or postnatal. The case of the newborn with a positive molecular test presented a negative serological test for SARS-CoV-2 infection. 46 other newborns were born with a negative molecular test, 17 had positive IgM / positive IgG antibodies and 5 had only positive IgG
Community evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission through air	Lin,  G,  Zhang, et al	Atmospheric Environment	Epidemiology| Épidémiologie Transmission	Nine cases of COVID-19 were found in a building were all cases lived in three vertically aligned units of one building sharing the same piping system, which provided one unique opportunity to examine the transmission mode of SARS-CoV-2. A simulation experiment in the building and a parallel control experiment in a similar building were then conducted to investigate the possibility of transmission through air. Phylogenetic analyses showed that virus of all the patients were from the same strain of the virus. No close contacts between the index cases and other families indicated that the transmission might not occur through droplet and close contacts. Airflow detection and simulation experiment revealed that flushing the toilets could increase the speed of airflow in the pipes and transmitted the airflow from Apartment 15-b to 25-b and 27-b. Reduced exhaust flow rates in the infected building might have contributed to the outbreak.
Sleep Conditions Associate with Anxiety and Depression Symptoms among Pregnant Women during the Epidemic of COVID-19 in Shenzhen	Lin,  W,  Wu, et al	Journal of affective disorders	Mental Health | santé mentale	The associations between sleep conditions and anxious and depressive symptoms among pregnant women remained to be investigated, particularly during the epidemic of COVID-19. In total, 751 pregnant women from Shenzhen were enrolled. Overall, 82.7% of the respondents considered low risk of being infected by COVID-19. The prevalence of anxiety and depression symptoms during the epidemic of COVID-19 among pregnant women were 13.4% and 35.4%, respectively, but most of which were mild. Variables referred to poor sleep conditions were strongly associated with anxious and depressive symptoms, including random or late time of going to bed, difficulty in falling sleep, short sleep duration, and ordinary or poor subjective sleep quality.
Spread Mechanism and Influence Measurement of Online Rumors during COVID-19 Epidemic in China	Lin,  Yiou,  Lei, et al	arXiv	Public Health response| Interventions de santé publique	We analyzed the rumor spread mechanism and proposed a method to quantify the rumor influence by the speed of new insiders in China. We use the search frequency of rumor as an observation variable of new insiders. We calculated the peak coefficient and attenuation coefficient for the search frequency, which conform to the exponential distribution. Then we designed several rumor features and used the above two coefficients as predictable labels. Our feature analysis shows that precursor features are the most important for the outbreak coefficient, while location information and rumor entity information are the most important for the attenuation coefficient. Meanwhile, features which are conducive to the outbreak are usually harmful to the continued spread of rumors. At the same time, anxiety is a crucial rumor-causing factor.
PMC7675481; Elevated fasting blood glucose within the first week of hospitalization was associated with progression to severe illness of COVID-19 in patients with preexisting diabetes: A multicenter observational study	Ling,  P,  Luo, et al	J Diabetes	Epidemiology| Épidémiologie Clinical data| Données cliniques	We conducted this study to investigate the association of glycosylated hemoglobin (HbA1c) and the outcome of COVID‐19 and determine the optimal glucose level during the early stage of their hospitalization among patients with preexisting diabetes, in a cohort of laboratory‐confirmed COVID‐19 patients in China. A total of 702 COVID‐19 patients were included in this study. Among them, 51(7.26%) had preexisting diabetes, all of them had type 2 diabetes mellitus (T2D). Compared with patients without diabetes (Table 1), those with diabetes were more likely to progress to severe illness (45.10% vs 8.91%, relative risk [RR] 5.06, 95% confidence interval [CI] 3.43‐7.48) and to be admitted to the intensive care unit (ICU) (31.37% vs 3.99%, RR 7.86, 95% CI 4.52‐13.67).
COVID-19 associated stress among dental students	Lingawi,  HS,  Afifi, et al	Open Dentistry Journal	Mental Health | santé mentale	The objective of this study was to assess levels of COVID-19 related stress and anxiety, changes in hygienic and social habits, as well as subjective worries regarding the dental profession among dental students (College of Dentistry, Umm Al-Qura University). Moderate and severe anxiety were reported in 17% and 4% of students, respectively, with non-significant associations between anxiety and gender or level of study. A high percentage of students (46.5% to 62.4%) reported great change in most hygienic and social habits with a highly significant association between change in buying more sanitizers and anxiety levels. Forty-six percent agreed that their job performance was not at its best, and 31% reported a possible intention to change profession, with the latter reported more by male students (63.8%).
Prevalence of COVID-19 in Italian children with celiac disease: a cross-sectional study	Lionetti,  E,  Fabbrizi, et al	Clin Gastroenterol Hepatol	Epidemiology| Épidémiologie Clinical data| Données cliniques	This phone-based survey study was conducted in order to investigate the prevalence of and clinical features of COVID-19 in children with celiac disease in Italy. Prevalence of confirmed COVID-19 in our cohort was therefore 0/387 (95%CI: 0.0000-0.0095). Fifteen (3.9%) patients reported fever without other associated symptoms, but tested negative for COVID-19 at the nasopharyngeal swab. Twenty-three (5.9%) patients were assigned to the COVID-19 like group (9 with fever and cough; 2 with fever, vomit and diarrhea; 10 with diarrhea and/or vomit; 2 with cough); none of these patients had respiratory failure, developed pneumonia, needed oxygen administration nor required hospital admission.
Clinical characteristics and follow-up analysis of 324 discharged covid-19 patients in shenzhen during the recovery period	Liu,  HQ,  Yuan, et al	International Journal of Medical Sciences	Clinical data| Données cliniques Immunology | Immunologie	We retrospectively analysed the epidemiological information, discharge summaries, and laboratory results of 324 patients in order to collect information on  clinical features, recovery process, and antibody reactions during the recovery period. Results indicate that recovered COVID-19 patients need psychological and physiological care and treatment, re-positivity can occur in any person, but juveniles, females, and patients with mild/moderate existing symptoms have higher rates of re-positivity, While there is no evidence that turning re-positive has an impact on their infectivity, but it still alerted us that we need differentiate them in the following management.
PMC7716285; Safety and Efficacy of Ixekizumab and Antiviral Treatment for Patients with COVID-19: A structured summary of a study protocol for a Pilot Randomized Controlled Trial	Liu,  P,  Huang, et al	Trials	RCT	(Protocol) We aim to explore the safety and efficacy of ixekizumab (an injectable drug for the treatment of autoimmune diseases) to prevent organ injury caused by the immune response to COVID-19 through a structured summary randomized controlled trial.
Acupoint Application Therapeutic Mechanism for Novel Coronavirus Pneumonia: A Network Pharmacology Analysis	Liu,  Shan,  Zhang, et al	Research Square prepub	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	We sought to explore the key targets and mechanisms of Ephedra and Asarum, the main components used in acupoint application (AA), in the treatment of COVID-19 in this study. The active compounds and related targets of Ephedra and Asarum used in AA were screened by searching four databases. COVID-19-related target genes were identified from three disease databases, and the key targets of treating COVID-19 were obtained by Venn diagram using Cytoscape 3.2.1 software, gene ontology (GO) enrichment analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were used to explore possible mechanisms and pathways. The top pathways included Immune System, Cytokine Signaling in Immune System, Adaptive Immune System, Signaling by Interleukins, Innate Immune System, and Signaling by GPCR.
An inter-correlated cytokine network identified at the center of cytokine storm predicted COVID-19 prognosis	Liu,  Y,  Chen, et al	Cytokine	Clinical data| Données cliniques Immunology | Immunologie	The present study analyzed maximal and early (within 10 days after disease onset) concentrations of 12-plex cytokines in plasma. We found consistently elevated plasma levels of IL-6, IL-8 and IL-5 in patients who were deceased compared with those who had mild/moderate or severe disease. The early plasma concentrations of IFN-a and IL-2 positively correlated with the length of the disease course. Moreover, correlation network analysis showed that IL-6, IL-8, and IL-5 located at the center of an inter-correlated cytokine network.
Morphological changes of lymphocytes in peripheral blood smears of patients with covid-19	Liu,  YP,  Liu, et al	Annals of Palliative Medicine	Clinical data| Données cliniques Immunology | Immunologie	This pilot study was to investigate whether SARS-CoV-2 infection causes morphological changes in peripheral lymphocytes in 23 most recently hospitalized patients. Our results showed that the highest percentage of atypical lymphocytes was just 4%, while the second highest in our cohort was 2%. The rest were all around 1%. Most of the atypical lymphocytes observed in our cohort was just irregular shaped lymphocytes with excessive cytoplasm but normal nucleus. Plasmacytoid lymphocytes were also observed but with a low percentage, which was in agreement with other studies.
Relationship between initial CT signs and symptoms onset time in COVID-19 patients outside Wuhan	Liu,  Z,  Liang, et al	Journal of Xi'an Jiaotong University (Medical Sciences)	Clinical data| Données cliniques	The objective of this study was to explore the correlation between initial chest CT signs and onset time in patients with coronavirus disease 2019 (COVID-19) outside Wuhan area and to identify the early changes in chest CT signs. Results indicate that the main CT manifestations of patients with COVID-19 are ground glass opacities (GGO) and GGO combined with consolidation, and the 7th day of onset may be the key time point for the change of CT signs.
PMC7709603; No evidence of SARS-CoV-2 circulation in HIV-infected patients between December 2019 and February 2020 in Rome, Italy	Lombardi,  F,  Belmonti, et al	Clin Microbiol Infect	Epidemiology| Épidémiologie Immunology | Immunologie	In this monocentric cross-sectional study we evaluated the IgG seroprevalence of SARS-CoV-2 infection in HIV-infected outpatients who frequented our university hospital “Fondazione Policlinico Universitario A. Gemelli IRCCS”, in Rome between December 1st, 2019 and February 29th, 2020. Our analysis revealed a seroprevalence of 0% (n=0/451; 95% CI, 0.00–0.008%). Thus, in our study no evidence of SARS-CoV-2 circulation in HIV-infected patients before March 2020 in Rome was observed.
Australian private practice metropolitan telepsychiatry during the COVID-19 pandemic: analysis of Quarter-2, 2020 usage of new MBS-telehealth item psychiatrist services	Looi,  JC,  Allison, et al	Australas Psychiatry	Healthcare Response | Réponse des soins de santé	We investigate private psychiatrists' uptake of (1) video- and telephone-telehealth consultations for Quarter-2 (April-June) of 2020 and (2) total telehealth and face-to-face consultations in Quarter-2, 2020 in comparison to Quarter-2, 2019 for Australia. Combined telehealth and face-to-face psychiatry consultations rose during the first wave of the pandemic in Quarter-2, 2020 by 14% compared to Quarter-2, 2019 and telehealth was approximately half of this total. Face-to-face consultations in 2020 comprised only 56% of the comparative Quarter-2, 2019 consultations. Most telehealth provision was by telephone for short consultations of ⩽15-30 min. Video consultations comprised 38% of the total telehealth provision (for new patient assessments and longer consultations).
Clinical outcomes and characteristics of patients hospitalized for Influenza or COVID-19 in Germany	Ludwig,  M,  Jacob, et al	Int J Infect Dis	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objective of this study was to compare clinical and demographic characteristics of German patients hospitalized for infection with either SARS-CoV-2 or Influenza.· Male sex and old age associated with poor outcome for both diseases. Overall in-hospital mortality is two-fold higher for COVID-19 patients. Ventilation time is more than three times longer for COVID-19 compared to Influenza. COVID-19 patients discharged after ventilation stayed in hospital twice as long. Proportion of patients with severe outcomes higher for COVID-19 than for Influenza.
Application of chest low-dose CT screening of Corona Virus Disease 2019 with a third-generation dual-source scanner	Luo,  K,  Lei, et al	Chinese Journal of Radiological Medicine and Protection	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	To investigate the application value of third-generation dual-source CT(3-G DSCT) low-dose scan mode combined with iterative reconstruction technology in the screening of COVID-19 and to evaluate the radiation dose. In the screening of COVID-19, using low-dose scanning mode of 3-G DSCT combined with iterative reconstruction technology would provide diagnostic quality images and meanwhile effectively reduce the radiation dose and improve the SNR of the image.
A nomogramic model based on clinical and laboratory parameters at admission for predicting the survival of COVID-19 patients	Ma,  X,  Wang, et al	BMC Infectious Diseases	Epidemiology| Épidémiologie Clinical data| Données cliniques	The present study aimed to develop a nomogram model to predict the survival of COVID-19 patients based on their clinical and laboratory data at admissionA nomogram based on age, CHD, Lym%, platelets, C-reaction protein, LDH and D-dimer was established to accurately predict the prognosis of COVID-19 patients.
High rate of major drug–drug interactions of lopinavir–ritonavir for COVID-19 treatment	Macías,  J,  Pinilla, et al	Scientific Reports	Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique	We evaluated the rate and severity of DDI between LPV-r for COVID-19 treatment and concomitant medications.  A high frequency of DDI between LPV-r for treating COVID-19 and concomitant medications was found, including major DDI. Patients with major DDI showed worse outcomes, but this association was explained by the older age and comorbidities. Patients managed by the Infectious Diseases Unit had lower risk of major DDI.
The impact of seasonal respiratory virus transmission on syndromic surveillance for COVID-19 in Ontario, Canada	Maharaj,  ArjunaS,  Parker, et al	medRxiv	Epidemiology| Épidémiologie Surveillance	Here we investigated the role of non-SARS-CoV-2 respiratory virus test positivity on COVID-19 two independent syndromic surveillance systems in Ontario, Canada. We compared the weekly number of reported COVID-19 cases reported in the province of Ontario against two syndromic surveillance metrics: 1) the proportion of respondents with a self-reported COVID-like illness (CLI) from COVID Near You (CNY) and 2) the proportion of emergency department visits for upper respiratory conditions from the Acute Care Enhanced Surveillance (ACES) system. Two methods of syndromic surveillance showed strong positive correlations with COVID-19 confirmed case counts before and during a rise in circulating entero/rhinovirus. However, as positivity for enterovirus/rhinovirus fell in late September 2020, syndromic signals became uncoupled from COVID-19 cases and instead tracked the fall in entero/rhinovirus. This finding provides proof-of-principle that regional transmission of seasonal respiratory viruses may complicate the interpretation of COVID-19 surveillance data.
Medication access difficulty and COVID-related distress are associated with disease flares in rheumatology patients during the COVID-19 pandemic	Maldonado,  D,  Tu, et al	Arthritis Care Res (Hoboken)	Mental Health | santé mentale Healthcare Response | Réponse des soins de santé	We surveyed adult patients and parents of pediatric patients from rheumatology clinics in the Bronx, in the month following the epidemic peak regarding medication access, medication interruptions, COVID‐19 infection, COVID‐19 hospitalization, and COVID‐related distress. Of 1,692 patients and parents contacted, 361 (21%) responded; 16% reported medication access difficulty, 14% medication interruptions, and 41% flare. In a multivariable logistic regression model, medication access difficulty was associated with increased odds of flare (OR 4.0, 95% CI 1.5‐10.4, p=0.005), as was high COVID‐related distress (OR 2.4, 95% CI 1.2‐4.6, p=0.01). In multivariable linear regression models, medication access difficulty and high distress were associated with worse disease activity scores and high distress was associated with worse health scores.
Novel Approach for Monte Carlo Simulation οf the new COVID-19 Spread Dynamics	Maltezos,  Stavros,  Georgakopoulou, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	A Monte Carlo simulation in a novel approach is used for studying the problem of the outbreak and spread dynamics of the new virus COVID-19 pandemic in this work. In particular, our goal was to generate epidemic data based on the natural mechanism of the transmission of this disease assuming random interactions of a large-finite number of individuals in very short distance ranges. In the simulation we also take into account the stochastic character of the individuals in a finite population and given densities of people. On the other hand, we include in the simulation the appropriate statistical distributions for the parameters characterizing this disease. An important outcome of our work, apart of the produced epidemic curves, is the methodology of determination of the effective reproductive number during the main part of the new daily cases of the epidemic. Because this quantity constitutes a fundamental parameter of the SIR-based epidemic models, we also studied how it is affected by small variations of the incubation time and the crucial distance distributions, and furthermore, by the degree of quarantine measures. Moreover, we compare our qualitative results with that of selected real epidemic data from some world wide countries.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialNot yet registered because is a new study in this field.Funding StatementWithout any funding.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Exemption.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe data concern the parameters and applied on epidemiological data.
Influence of COVID-19 confinement measures on appendectomies in Germany-a claims data analysis of 9797 patients	Maneck,  M,  Günster, et al	Langenbecks Arch Surg	Healthcare Response | Réponse des soins de santé	The aim of this retrospective study was to assess if the obligatory confinement (lockdown) had an effect on the number of appendectomies (during and after the period of lockdown).The lockdown in Germany resulted in a decreased number of appendectomies. This affected mainly appendectomies in simple acute and non-acute appendicitis, but not complicated acute appendicitis.
Risk Perception of COVID-19 Community Transmission among the Spanish Population	Mansilla Domínguez,  JM,  Font Jiménez, et al	Int J Environ Res Public Health	Public Health response| Interventions de santé publique	On 11 March 2020 the SARS-CoV-2 virus was officially declared a pandemic and measures were set up in various countries to avoid its spread among the population. This paper aims to analyse the perception of risk of COVID-19 infection in the Spanish population. A cross-sectional, descriptive observational study was conducted with a total of 16,372 Spanish participants. An online survey was used to gather data for 5 consecutive days over the compulsory lockdown period which was established after the state of emergency was declared. There is an association between socio-demographic variables and risk perception, and a very strong relationship between this perception and contact and direct experience with the virus in a family, social or professional setting. We also found that compared to working from home, working outside the home increased the perception of risk of infection and the perception of worsening health. Understanding the public perception of the risk of COVID-19 infection is fundamental for establishing effective prevention measures.
A Cross-sectional Survey on the Impact of Coronavirus Disease 2019 on the Clinical Practice of Endodontists across the United States	Martinho,  FC,  Griffin, et al	Journal of endodontics	Healthcare Response | Réponse des soins de santé	This survey investigated the effect of the coronavirus disease 2019 (COVID-19) pandemic on the clinical practice of endodontics among the American Association of Endodontists (AAE) members. N95 respirator face mask was described by 83.1% of the participants as special measures beyond the regular personal protective equipment. Rubber dam isolation was recognized by the majority of the participants at some level to reduce the chance of COVID-19 cross infection. Most of the endodontist participants acknowledged trauma followed by swelling, pain, and postoperative complication to be emergencies. The majority of respondents reported being concerned about the effect of COVID-19 on their practice. No differences in worries about COVID-19 infection were related to demographics (P > .05). The majority of the endodontists are aware of the COVID-19 pandemic, are taking special precautions, and are concerned about contracting and spreading the virus
SARS-CoV-2 pandemic impact on pediatric emergency rooms: A multicenter study	Matera,  L,  Nenna, et al	International Journal of Environmental Research and Public Health	Healthcare Response | Réponse des soins de santé	Our aim was to evaluate how the SARS-CoV-2 pandemic and related preventive strategies affected pediatric emergency rooms (ERs) during this period. We examined 15 Italian pediatric ERs in terms of visit rates, specific diagnoses (grouped as air communicable diseases and non-air communicable diseases), and triage categories. During the lockdown period, ER admissions decreased by 81% compared to 2019 (52,364 vs. 10,112). All ER specific diagnoses decreased in 2020 and this reduction was significantly higher for air communicable diseases (25,462 vs. 2934, p < 0.001). Considering the triage category, red codes remained similar (1% vs. 1%), yellow codes increased (11.2% vs. 22.3%), and green codes decreased (80.3% vs. 69.5%). We can speculate that social distancing and simple hygiene measures drastically reduced the spread of air communicable diseases. The increase in yellow codes may have been related to a delay in primary care and, consequently, in ER admissions.
Quantifying the shift in social contact patterns in response to non-pharmaceutical interventions	McCarthy,  Z,  Xiao, et al	Journal of Mathematics in Industry	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	We develop and utilize a novel methodology, integrating social contact patterns derived from empirical data with a disease transmission model, that enables the usage of age-stratified incidence data to infer age-specific susceptibility, daily contact mixing patterns in workplace, household, school and community settings; and transmission acquired in these settings under different physical distancing measures. We demonstrated the utility of this methodology by performing an analysis of the COVID-19 epidemic in Ontario, Canada. We quantified the age- and setting (household, workplace, community, and school)-specific mixing patterns and their evolution during the escalation of public health interventions in Ontario, Canada.  We estimated a reduction in the average individual contact rate from 12.27 to 6.58 contacts per day, with an increase in household contacts, following the implementation of control measures. We also estimated increasing trends by age in both the susceptibility to infection by SARS-CoV-2 and the proportion of symptomatic individuals diagnosed.
PMC7708797; Parent anxiety and perceptions of their child's physical activity and sedentary behaviour during the COVID-19 pandemic in Canada	McCormack,  GR,  Doyle-Baker, et al	Prev Med Rep	Mental Health | santé mentale	The purpose of this study was to examine the associations between parent COVID-19 anxiety and physical activity and sedentary behaviours among school-aged children (5-17 years) and; to describe these behaviour patterns among school-aged children in relation to the COVID-19 public health emergency response in Calgary, Canada.  Approximately one-third of parents (35.7%) reported being extremely or very anxious about COVID-19. During this period, most children increased television watching (58.8%), computing or gaming (56.4%), and use of screen-based devices (75.9%). Not surprisingly, given the mandated closure of playgrounds, approximately one-half of children decreased playing at the park (52.7%) and in public spaces (53.7%). Children’s physical activity at home either increased (48.8%) or remained unchanged (32.9%). Children of more anxious parents had fewer visits to the park and were more likely to spend ≥2 hours/day computing or gaming compared with children of less anxious parents.
COVID-19: it happens to nurses too-a case study	McDonald,  G,  Clark, et al	Br J Community Nurs	Clinical data| Données cliniques	This short case study describes the journey of an emergency department (ED) charge nurse who contracted COVID-19 and was hospitalised in the intensive care unit (ICU).
Correlates of protection against SARS-CoV-2 in rhesus macaques	McMahan,  K,  Yu, et al	Nature	Immunology | Immunologie Animal model | Modèle animal	Authors show that adoptive transfer of purified IgG from convalescent macaques protects naïve recipient rhesus macaques against SARS-CoV-2 challenge in a dose dependent fashion. Depletion of CD8+ T cells in convalescent animals partially abrogated the protective efficacy of natural immunity against SARS-CoV-2 re-challenge, suggesting the importance of cellular immunity in the context of waning or subprotective antibody titers. These data demonstrate that relatively low antibody titers are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may also contribute to protection if antibody responses are suboptimal. We also show that higher antibody titers are required for therapy of SARS-CoV-2 infection in macaques.
Modeling the effect of contaminated objects for the transmission dynamics of COVID-19 pandemic with self protection behavior changes	Mekonen,  KG,  Habtemicheal, et al	Results in Applied Mathematics	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	A mathematical model for the transmission dynamics of Coronavirus diseases (COVID-19) is proposed using a system of nonlinear ordinary differential equations by incorporating self protection behavior changes in the population. We found out that the reproduction number depends mostly on the infection rates, the threshold value of the force of infection for a population, the recovery rates, and the virus decay rate in the environment. It illustrates that control of the effective transmission rate (recommended human behavioral change towards self-protective measures) is essential to stop the spreading of the virus. Numerical simulations of the model were performed to supplement and verify the effectiveness of the analytical findings.
PMC7690274; Acute appendicitis in four children with SARS-CoV-2 infection	Meyer,  JS,  Robinson, et al	J Pediatr Surg Case Rep	Clinical data| Données cliniques	We describe 4 children (11-17 years in age) at our institution with acute appendicitis in the setting of SARS-CoV-2 infection, suggesting a possible association. Providers should consider testing for this infection in patients with severe gastrointestinal symptoms, in order to take appropriate transmission based precautions, until more is understood.
Association between Participation in Government Subsidy Program for Domestic Travel and Symptoms Indicative of COVID-19 Infection	Miyawaki,  Atsushi,  Tabuchi, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	To investigate the association between participation in government subsidies for domestic travel in Japan and the incidence of COVID-19 infections. We found that the participants of the subsidy program exhibited higher incidence of high fever (adjusted rate, 4.8% for participants vs. 3.7% for non-participants; adjusted odds ratio [aOR], 1.90; 95%CI, 1.40-2.56; p<0.001), throat pain (20.0% vs. 11.3%; aOR, 2.13; 95%CI, 1.39-3.26; p=0.002), cough (19.2% vs. 11.2%; aOR 1.97; 95%CI, 1.28-3.03; p=0.004), headache (29.4% vs. 25.5%; aOR, 1.26; 95%CI, 1.09-1.46; p=0.005), and smell and taste disorder (2.6% vs. 1.7%; aOR 2.01; 95%CI; 1.16-3.49; p=0.01) compared with the non-participants.
Longitudinal symptom dynamics of COVID-19 infection	Mizrahi,  B,  Shilo, et al	Nat Commun	Clinical data| Données cliniques Long-Term Sequelae | séquelles à long terme	We extracted data from primary-care electronic health records and nationwide distributed surveys to assess the longitudinal dynamics of symptoms prior to and throughout SARS-CoV-2 infection. Information was available for 206,377 individuals, including 2471 positive cases. The two datasources were discordant, with survey data capturing most of the symptoms more sensitively. The most prevalent symptoms included fever, cough and fatigue. Loss of taste and smell 3 weeks prior to testing, either self-reported or recorded by physicians, were the most discriminative symptoms for COVID-19. Additional discriminative symptoms included self-reported headache and fatigue and a documentation of syncope, rhinorrhea and fever. Children had a significantly shorter disease duration. Several symptoms were reported weeks after recovery. By a unique integration of two datasources, our study shed light on the longitudinal course of symptoms experienced by cases in primary care.
PMC7708825; The number of obstructive colorectal cancers in Japan has increased during the COVID-19 pandemic: A retrospective single-center cohort study	Mizuno,  R,  Ganeko, et al	Ann Med Surg (Lond)	Healthcare Response | Réponse des soins de santé	We investigated the impact of the COVID-19 pandemic on the characteristics of colorectal cancer (CRC) patients in facilities that are on the frontline of both COVID-19 and cancer treatments., Although the number of CRC patients did not show a significant change related to the pandemic, the incidence of obstructive CRCs significantly increased after the pandemic's start. The numbers of outpatients and colonoscopies both decreased, which could have resulted in the decrease of CRC patients detected by cancer screening during the pandemic. The numbers of symptomatic CRC patients and emergency admissions both increased significantly during the pandemic.
Detailed disease progression of 213 patients hospitalized with Covid-19 in the Czech Republic: An exploratory analysis	Modrak,  Martin,  Burkner, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	We collected a multi-centric retrospective dataset of patients (N = 213) who were admitted to ten hospitals in Czech Republic and tested positive for SARS-CoV-2. Patients in the dataset were treated with hydroxychloroquine (N = 108), azithromycin (N = 72), favipiravir (N = 9), convalescent plasma (N = 7), dexamethasone (N = 4) and remdesivir (N = 3), often in combination.  Weak evidence to constrain the potential efficacy of azithromycin and favipiravir can be extracted from the data. Additionally, we performed external validation of several proposed prognostic models for Covid-19 severity showing that they mostly perform unsatisfactorily on our dataset.
Eosinophil count as the predictor of main outcomes of COVID 19: Case-control study	Mohammed,  HS	European Journal of Molecular and Clinical Medicine	Epidemiology| Épidémiologie Clinical data| Données cliniques	The study was implemented to construct a link between eosinopenia and COVID 19 concerning diagnostic usefulness, anticipation of deleterious ramifications, and lethality in COVID 19 cases. (52) of entire sample were eosinopenic,(48) were non-eosinopenic,(46) of eosinopenic patient belong to COVID-19 category but just (6) belong to control category with significant difference (p value=0.001).(27) patients from COVID-19 category elected to be transferred to ICU services, concurrently just(5) patients from control category seek ICU service,(26) patient from COVID-19 category who were admitted to ICU are eosinopenic meanwhile just one in control category was eosinopenic(odd ratio:1.053).(26) patients of COVID-19 category died meanwhile (5) patients from control category died,(25) patients who died in COVID-19 category were eosinopenic meanwhile just one in control category was eosinopenic(Odd ratio:1.565).
The impact of the COVID-19 pandemic on ophthalmic care at an eye-specific emergency department in an outbreak hotspot	Moon,  JY,  Miller, et al	Clinical Ophthalmology	Healthcare Response | Réponse des soins de santé	We analyzed patterns of ED visits at an eye-specific ED since the declaration of the public health crisis. Overall, the median number of daily visits to the ED decreased by 18 visits per day since the declaration of public health guidelines (interquartile range, 9– 24, p < 0.001). This accounted for a 32% decrease in the total volume of ED visits in 2020 compared to prior years during the study period (p < 0.001). There was a 9% increase in the proportion of primary diagnoses considered urgent (p = 0.002). The proportion of visits requiring urgent surgery increased by 39% (p = 0.004).
Predicting COVID-19 (Coronavirus Disease) Outbreak Dynamics Using SIR-based Models: Comparative Analysis of SIRD and Weibull-SIRD	Mosavi,  Amir,  Sedaghat, et al	SSRN- Lancet prepublication	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	We propose a novel method that integrates an analytical solution of the infectious population using Weibull distribution function into any SIR type models. The Weibull-SIRD method has easily fitted 4 set of COVID-19 biological data simultaneously. It is demonstrated that the Weibull-SIRD method predictions for susceptible, infected, recovered, and deceased populations from COVID-19 in Kuwait and UAE are superior compared with SIRD original ODE model.
An Affordable, User-Friendly Telerehabilitation System Assembled Using Existing Technologies for Individuals Isolated Due to COVID-19: A Feasibility Study	Mukaino,  M,  Tatemoto, et al	JMIR Rehabil Assist Technol	Healthcare Response | Réponse des soins de santé	This study aimed to investigate the feasibility of a telerehabilitation system developed for quarantined patients due to COVID-19 by combining existing commercial devices and computer applications. Out of 10 patients, 9 were able to use the telerehabilitation system without any on-site help. On the TSQ, the mean score for each item was 4.7 ± 0.7, and in the additional items regarding telerehabilitation, the mean score for each item was 4.3 ± 1.0. These findings support the overall feasibility of this simple telerehabilitation system in quarantined patients with COVID-19, encouraging further development and implementation of telerehabilitation in clinical practice.
Addressing machine learning concept drift reveals declining vaccine sentiment during the COVID-19 pandemic	Müller,  Martin,  Salathé, et al	arXiv	Public Health response| Interventions de santé publique	we explore the effect of machine learning concept drift by focussing on vaccine sentiments expressed on Twitter, a topic of central importance especially during the COVID-19 pandemic. We show that while vaccine sentiment has declined considerably during the COVID-19 pandemic in 2020, algorithms trained on pre-pandemic data would have largely missed this decline due to concept drift. Our results suggest that social media analysis systems must address concept drift in a continuous fashion in order to avoid the risk of systematic misclassification of data, which is particularly likely during a crisis when the underlying data can change suddenly and rapidly.
Behavioral Implications of the Covid-19 Process for Autism Spectrum Disorder, and Individuals' Comprehension of and Reactions to the Pandemic Conditions	Mutluer,  T,  Doenyas, et al	Frontiers in Psychiatry	Public Health response| Interventions de santé publique	We conducted an investigation of how individuals with ASD responded to Covid-19 in terms of comprehension and adherence to implemented measures; changes in their behavioral problems; and how their caregivers' anxiety levels relate with these behavioral changes. The majority of our sample had problems understanding what Covid-19 is and the measures it requires. They also had challenges in implementing social distance and hygiene-related regulations of the pandemic. The majority stopped receiving special education during this period. We observed a Covid-19-related clinical presentation that resembled PTSD in individuals with ASD in terms of increased stereotypies, aggression, hypersensitivity, behavioral problems, and sleep and appetite alterations. All subscales of Aberrant Behavior Checklist (ABC) differed significantly between before and after the pandemic conditions. The number of hours the children slept significantly decreased from before to during Covid-19. The anxiety levels of caregivers were high and correlated with the current behavioral problem levels of their children, but not with the level of their behavioral problems before the pandemic. The difference in ABC total score and specifically the lethargy/social withdrawal subscale score predicted parents' anxiety score.
PMC7714733; A Prospective Study on Rapidly Declining SARS-CoV-2 IgG Antibodies Within One to Three Months of Testing IgG Positive: Can It Lead to Potential Reinfections?	Nag,  DS,  Chaudhry, et al	Cureus	Clinical data| Données cliniques Immunology | Immunologie	a prospective clinical trial was planned by repeating the test for IgG antibodies on the remaining earlier positive 235 individuals at 45-65 days after their initial test. Only 201 of the 235 individuals consented and participated in the non-randomized single-arm observational trial. Only 28.36% (57/201) retained their IgG antibodies and 70.15% (141/201) had lost their IgG antibodies. Three cases reported equivocal results on retesting. Our findings show that the protective COVID-19 IgG antibodies rapidly decline over one to three months.
Household factors and the risk of severe COVID-like illness early in the US pandemic	Nash,  Denis,  Qasmieh, et al	medRxiv	Epidemiology| Épidémiologie	To investigate the role of children in the home and household crowding as risk factors for severe COVID-19 disease. In logistic regression models, the adjusted odds ratio [aOR] of hospitalization due to COVID-19 for having (versus not having) children in the home was 10.5 (95% CI:5.7-19.1) among study participants living in multi-unit dwellings and 2.2 (95% CI:1.2-6.5) among those living in single unit dwellings. Among participants living in multi-unit dwellings, the aOR for COVID-19 hospitalization among participants with more than 4 persons in their household (versus 1 person) was 2.5 (95% CI:1.0-6.1), and 0.8 (95% CI:0.15-4.1) among those living in single unit dwellings.
Surgical strategy and optimal timing of tracheostomy in patients with COVID-19: Early experiences in Japan	Nishio,  N,  Hiramatsu, et al	Auris Nasus Larynx	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	We reviewed our early experience with COVID-19 patients who underwent tracheostomy at one tertiary hospital in Japan from February to September 2020 and analyzed the timing of tracheostomy, operative results, and occupational infection in healthcare workers (HCWs). Of 16 patients received tracheal intubation with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, five patients (31%) received surgical tracheostomy in our hospital. The average consultation time for surgical tracheostomy was 7.4 days (range, 6 - 9 days) from the COVID-19 team to the otolaryngologist. The duration from tracheal intubation to tracheostomy ranged from 14 to 27 days (average, 20 days). The average time of tracheostomy was 27 min (range, 17 - 39 min), and post-wound bleeding occurred in only one patient. No significant differences in hemoglobin (Hb) levels were found between the pre- and postoperative periods (mean: 10.2 vs. 10.2 g/dl, p = 0.93). Similarly, no difference was found in white blood cell (WBC) count (mean: 12,200 vs. 9,900 cells /µl, p = 0.25). After the tracheostomy, there was no occupational infection among the HCWs who assisted the tracheostomy patients during the perioperative period.  We proposed a modified weaning protocol and surgical indications of tracheostomy for COVID-19 patients and recommend that an optimal timing for tracheostomy in COVID-19 patients of 2 - 3 weeks after tracheal intubation, from our early experiences in Japan.
X-ray patterns of COVID-19 in patients presenting to lady reading hospital, Peshawar, Pakistan	Nishtar,  T,  Noor, et al	Pakistan Journal of Medical Sciences	Clinical data| Données cliniques	Objective: To determine the pattern of COVID-19 on chest radiograph in patients presenting to Lady Reading Hospital, Peshawar, Pakistan. The most common pattern observed is alveolar opacities with predominant peripheral distribution either unilateral or more frequently bilateral, starting from the lower and mid zones extending to the upper zones and becoming diffuse with disease progression.
Optimization of imaging parameters in chest CT for COVID-19 patients: An experimental phantom study	Niu,  Y,  Huang, et al	Quantitative Imaging in Medicine and Surgery	Clinical data| Données cliniques	The present study aimed to investigate the factors affecting the detection of ground-glass nodules and exudative lesions in chest CT among COVID-19 patients and to find an appropriate combination of imaging parameters that optimize detection while effectively reducing the radiation dose. For chest CT among COVID-19 patients, it is recommended that 100 kV/40 mAs is used for average patients; the radiation dose can be reduced to 1.6 mGy with qualified images to detect ground-glass nodules and exudation lesions.
Management of venous thromboembolic disease in the era COVID-19. Recommendations of the Spanish phlebology and lymphology chapter of the SEACV	Norberto,  EMS,  Alonso, et al	Angiologia	Healthcare Response | Réponse des soins de santé	The present clinical practice guide of the Spanish Chapter of Phlebology and Lymphology and the Spanish Society of Angiology and Vascular Surgery, aims to give a series of recommendations on prophylaxis and treatment of VTE in patients infected with COVID-19, both at the hospital and outpatient, and advice on their clinical and ultrasound monitoring.
Pre-existing cardiovascular disease rather than cardiovascular risk factors drives mortality in COVID-19	O Gallagher,  , Kevin, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	Among 1,721 patients, 349 (20.3%) had pre-existing CVD, 888 (51.6%) had CV risk factors without CVD (RF-CVD), 484 (28.1%) had neither. Patients with CVD were older with a higher burden of non-CV comorbidities. During follow-up, 438 (25.5%) patients died: 37% with CVD, 25.7% with RF-CVD and 16.5% with neither. CVD was independently associated with in-hospital mortality among patients <70 years of age (adjusted HR 2.43 [95%CI 1.16-5.07]), but not in those ≥70 years (aHR 1.14 [95%CI 0.77-1.69]). RF-CVD were not independently associated with mortality in either age group (<70y aHR 1.21 [95%CI 0.72-2.01], ≥70y aHR 1.07 [95%CI 0.76-1.52]). Most CV complications occurred in patients with CVD (66%) versus RF-CVD (17%) or neither (11%; p<0.001). 213 [12.4%] patients developed venous thromboembolism (VTE). CVD was not an independent predictor of VTE.
Mainstreaming the private health sector in the response to COVID-19: Facility readiness assessment for screening services in Edo state, Nigeria	Obaseki,  DE,  Akoria, et al	Pan African Medical Journal	Healthcare Response | Réponse des soins de santé	This survey was carried out to assess private facility readiness in providing screening services in Edo State. A total of 252 health facilities were assessed, comprising 149 (59.1%) hospitals/clinics, 62 (24.6%) pharmacies and 41 (16.3%) laboratories. One hundred and forty-two (95.3%), 60 (96.8%) and 41 (100.0%) hospitals/clinics, pharmacies and laboratories, respectively had hand hygiene facilities. However, overall facility readiness assessment scores for screening services were low with only 51 (34.2%) hospitals/clinics, 2 (3.2%) pharmacies and 2 (4.9%) laboratories achieving high enough scores to be adjudged ready for screening services.
The impact of COVID-19 on emergency general surgery admissions and operative volumes: A single centre experience	O'Connell,  RM,  Khan, et al	Surgeon	Healthcare Response | Réponse des soins de santé	The aim of this study was to examine the impact of COVID-19 on the number of patients presenting to our institution with emergent surgical illnesses or requiring emergency general surgical procedures.  151 patients were admitted during the study period, compared to a total of 788 during the proceeding three years. Median age of admitted patients was 51.8 years, compared to 50.3 years formerly (p = 0.35). 53 emergency procedures were performed, compared to a median of 70 over the same period in the previous years (mean 0.87 per day versus 1.16 per day, 25.4% reduction, p = 0.05).
Temporal variations in the diagnostic performance of chest CT for Covid-19 depending on disease prevalence: Experience from North-Eastern France	Ohana,  M,  Muller, et al	European Journal of Radiology	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The purpose of this work was to analyze temporal variations in the diagnostic performance of chest CT for Covid-19 throughout the first wave, depending on disease prevalence variations between the ascending, peak and descending phases of the epidemic in North-Eastern France. 2194 consecutive chest CT were analyzed. Overall CT diagnostic performance was Se = 84.2 [82.0 ; 86.3], Sp = 86.6 [84.5 ; 88.5], PPV = 86.1 [84.0 ; 88.1], NPV = 84.7 [82.6 ; 86.7] and accuracy = 85.4 [83.9 ; 86.8], with no significant differences between chest and non-chest radiologists. Variations between the ascending (11 days, 281 chest CT, disease prevalence 37.0 %), the peak (18 days, 1167 chest CT, disease prevalence 64 %) and the descending phases (19 days, 746 chest CT, disease prevalence 32.2 %) were highest for PPV and NPV with a probability of difference >99.9 %, and smallest for accuracy and specificity with a probability of equivalence >98.8 %.
Significant inactivation of SARS-CoV-2 by a green tea catechin, a catechin-derivative and galloylated theaflavins in vitro</em&gt	Ohgitani,  Eriko,  Shin-Ya, et al	bioRxiv	Therapeutics| Thérapeutique	Potential effects of teas and their constituents on SARS-CoV-2 infection were studied in vitro. Infectivity of SARS-CoV-2 was significantly reduced by a treatment with green tea, roasted green tea or oolong tea.
Overcoming the challenge of COVID-19: A grounded theory approach to rural nurses' experiences	Ohta,  R,  Matsuzaki, et al	Journal of General and Family Medicine	Healthcare Response | Réponse des soins de santé	This study inquires into nurses' changing perceptions with regard to the efforts in preparation for working in a COVID-19 ward in the rural Japanese context. Four themes emerged from the data: pre–COVID-work perceptions, overcoming fear, shadow cast by working in the COVID-19 ward, and an integrated approach to the fear of COVID-19. The nurses initially felt unpredictable fear. However, the establishment of standard approaches and practices for COVID-19 gave them confidence in their safety and helped them regain sympathy for patients. Nevertheless, working on COVID-19 cases negatively affected their activities outside of the ward, and some of them developed an identity crisis as they feared for the future.
Skin Manifestations During the COVID-19 Pandemic in the Pediatric Emergency Department	Oliva Rodríguez-Pastor,  S,  Martín Pedraz, et al	Pediatr Int	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	We sought to define the etiology, clinical presentation, time course and outcomes of children presenting to the Emergency Department (ED) with cutaneous manifestations shortly after the first pandemic peak of COVID‐19 in Spain. The number of ED visits for chilblains, which are rare in pediatrics, was high soon after the first peak of COVID‐19 in Spain. The disease course was self‐limited, outcomes were favorable and the possibility of viral transmission was negligible as five patients demonstrated SARS‐CoV‐2 antibodies, and none tested positive by PCR.
Coronavirus disease 2019 re-infection: first report from Turkey	Ozaras,  R,  Ozdogru, et al	New Microbes and New Infections	Clinical data| Données cliniques	A 23-year-old woman presented to the hospital with fever (39°C), chills, fatigue, cough, headache, sore throat, muscle and joint pain on April 9, 2020. SARS-CoV-2 PCR from nasopharyngeal specimen was ordered. SARS-CoV-2 PCR was reported positive and she was given hydroxychloroquine for five days. She improved in 10 days and PCR studies on April 22, and April 27 remained negative. On 4 August 2020, she was re-admitted with fever (38.7°C), chills, fatigue, loss of appetite, taste and smell loss, muscle and joint pain. SARS-CoV-2 PCR was reported positive and she was prescribed hydroxychloroquine, acetaminophen and sent home for isolation again. She improved in one week (taste-smell loss improved in 10 days) and on follow-up visit after 14 days, she was doing well. PCR was negative on 17 August 2020. Her anti-SARS-CoV-2 antibodies were negative on 17 August 2020 and slightly positive (2.14 signal-to-cutoff) on 29 August 2020.
Hydroxychloroquine/Azithromycin treatment, QT interval and ventricular arrhythmias in hospitalized patients with COVID-19	Özdemir İ,  H,  Özlek, et al	Int J Clin Pract	Clinical data| Données cliniques Therapeutics| Thérapeutique	We aimed to evaluate association of Hydroxychloroquine (HCQ) or HCQ+azithromycin (AZM) treatment regimens, corrected QT (QTc) interval and malignant ventricular arrhythmias in hospitalized patients. Our cohort comprised 101 hospitalized COVID‐19 patients. The present study revealed that although HCQ+AZM treatment was independently associated with QTc prolongation, none of patients experienced malignant ventricular arrhythmia or death during treatment.
Mortality analysis of COVID-19 infection in chronic kidney disease, haemodialysis and renal transplant patients compared with patients without kidney disease: a nationwide analysis from Turkey	Ozturk,  S,  Turgutalp, et al	Nephrol Dial Transplant	Epidemiology| Épidémiologie Clinical data| Données cliniques	We conducted a multicentre, retrospective, observational study, involving hospitalized adult patients with COVID-19 from 47 centres in Turkey. Hospitalized COVID-19 patients with Chronic kidney disease (CKD), including Stages 3–5 CKD, haemodialysis (HD) and  renal transplantation (RT), have significantly higher mortality than patients without kidney disease.
A Henon map for the transmission dynamics of COVID-19: The role of asymptomatic transmitters and delayed symptoms	Pal,  Akshay,  Bhattacharjee, et al	arXiv	Modelling/ prediction| Modélisation/prédiction Transmission	We consider the transmission dynamics of COVID-19 which is characterized by two distinct features: the existence of asymptomatic carriers and the issue of latency which means that among the symptomatic carriers there could be a fraction whose symptoms develop after a couple of days.
Neutrophils mediate Th17 promotion in COVID-19 patients	Parackova,  Z,  Bloomfield, et al	Journal of leukocyte biology	Immunology | Immunologie	The main objective of this study was to assess the phenotypic and functional characteristics of neutrophils in COVID-19 patients, with particular focus on the interaction between neutrophils and T cells. In the COVID-19 neutrophil/T cell cocultures, neutrophils caused a strong polarity shift toward Th17, and, conversely, a reduction of IFNγ-producing Th1 cells. The Th17 promotion was NOS dependent. Neutrophils, the known modulators of adaptive immunity, skew the polarization of T cells toward the Th17 promotion and Th1 suppression in COVID-19 patients, contributing to the discoordinated orchestration of immune response against SARS-CoV-2. As IL-17 and other Th17-related cytokines have previously been shown to correlate with the disease severity
Modeling, estimation, and analysis of epidemics over networks: An overview	Paré,  PE,  Beck, et al	Annual Reviews in Control	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	We present and discuss a variety of mathematical models that have been proposed to capture the dynamic behavior of epidemic processes.
Development and optimization of a new method for direct extraction of SARS-CoV-2 RNA from municipal wastewater using magnetic beads	Parra Guardado,  AnaL,  Sweeney, et al	medRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	This paper describes the development and optimization of a direct method for extracting SARS-CoV-2 RNA from municipal wastewater using magnetic beads. Using this optimized magnetic bead-based extraction protocol, the presence of SARS-CoV-2 RNA was verified in wastewater collected from sewershed locations in Atlantic Canada.
Asymptomatic COVID-19 in hospital visitors: The underestimated potential of viral shedding	Passarelli,  VC,  Faico-Filho, et al	International Journal of Infectious Diseases	Epidemiology| Épidémiologie Clinical data| Données cliniques	On August 29th, 2020, visitors of hospitalized patients at São Paulo Hospital in São Paulo, Brazil, were enrolled for COVID-19 screening. Six of 150 (4%) asymptomatic visitors were diagnosed with COVID-19 at a hospital with a universal masking policy. Two inpatients (contacts) subsequently developed symptoms.
Fast Clearance of the SARS-CoV-2 Virus in a Patient Undergoing Vaccine Immunotherapy for Metastatic Chordoma: A Case Report	Pastor,  DM,  Lee-Wisdom, et al	Frontiers in Oncology	Clinical data| Données cliniques	A man with aggressive metastatic chordoma contracted the SARS-CoV-2 virus and was diagnosed with COVID-19 while undergoing intravenous brachyury vaccine immunotherapy. His disease course was remarkably mild, and the virus cleared rapidly. Despite a treatment delay of 3 months due to the COVID-19 pandemic, the patient’s disease has been stable and tumor-related pain has significantly improved. This suggests not only an intact, functional immune system, but also one that appears to have been responsive to cancer treatment.
Ayurveda may play a preventive role against viral infections including SARS-CoV-2 by the inactivation of furin protease	Paul,  D,  Chowdhury, et al	Journal of the Indian Chemical Society	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	This work summarizes few important viral pathogens that have gained particular attention in recent years and their possible remedies with ayurvedic medicine. Results obtained from in silico analysis of the common metabolites of tulsi (Ocimum sp.) revealed their effectiveness to inactive the furin enzyme. Interestingly, Ayurvedic medicines have been prepared as different formulations with several ingredients or metabolites might have potential to inactivate the furin protein by binding at various positions. Thus, it suggests that the combined or synergistic action of metabolites present in ayurvedic medicine may be a promising therapeutics to prevent viral diseases.
The effectiveness of population-wide, rapid antigen test based screening in reducing SARS-CoV-2 infection prevalence in Slovakia	Pavelka,  Martin,  van Zandvoort, et al	medRxiv	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	We report the results of recent mass testing for SARS-CoV-2 in Slovakia where rapid antigen tests were used to screen the whole population and to isolate infectious cases together with their household members. Prevalence of detected infections decreased by 58% (95% CI: 57-58%) within one week in the 45 counties that were subject to two rounds of mass testing. Adjusting for geographical clustering and differences in attendance rates and the epidemiological situation at the time of the first round, this changed to 61% (95% CI: 50-70%). Adjusting for an estimated growth rate in infections of 4.4% (1.1-6.9%) per day in the week preceding the mass testing campaign and the corresponding expected growth in infection prevalence, the estimated decrease in prevalence compared to a scenario of unmitigated growth was 70% (67-73%).
Icatibant in Severe Acute Respiratory Syndrome Coronavirus 2: a case description	Pecori,  D,  Della Siega, et al	J Investig Allergol Clin Immunol	Clinical data| Données cliniques	We describe the case of a 56-year-old man, admitted for COVID-19 pneumonia in absence of comorbidity. Because of the respiratory symptoms worsening despite these treatments, Icatibant was started on the second day of hospitalization. After administration of Icatibant, the patient presented a progressive clinical improvement.
SALVAGE LOBECTOMY TO TREAT NECROTIZING SARS-CoV-2 PNEUMONIA COMPLICATED BY A BRONCHOPLEURAL FISTULA	Peeters,  K,  Mesotten, et al	Ann Thorac Surg	Clinical data| Données cliniques	We report a case of necrotizing SARS-CoV-2 pneumonia complicated by bronchopleural fistula and treated by decortication and salvage lobectomy.
An Evaluation of Neurosurgical Practices During the Coronavirus Disease 2019 Pandemic	Pelargos,  PE,  Chakraborty, et al	World Neurosurgery	Healthcare Response | Réponse des soins de santé	We sought to understand how the coronavirus disease 2019 pandemic has affected the neurosurgical workforce. 457 neurosurgeons completed the survey. Nearly all respondents reported hospital restrictions on elective surgeries. Most reported a decline in clinic and operative volume. Nearly 70% of respondents saw a decrease in the work hours of their ancillary providers, and almost one half (49.1%) of the respondents had had to downsize their practice staff, office assistants, nurses, schedulers, and other personnel. Overall, 43.6% of survey respondents had experienced a decline in income, and 27.4% expected a decline in income in the upcoming billing cycle. More senior neurosurgeons and those with a private practice, whether solo or as part of a group, were more likely to experience a decline in income as a result of the pandemic compared with their colleagues.
Prolonged 59-day course of COVID-19: The case of a SARS-CoV-2 shedding persistency in a healthcare provider	Penchenat,  A,  Alavi, et al	Clinical Case Reports	Clinical data| Données cliniques	We report the case of a 25 years old woman, working as a resident at the dental clinic of Brest University Hospital, who developed the symptoms of COVID‐19 and was tested positive for SARS‐CoV‐2 RNA twice during 53 days.
Computational Insights into the Conformational Accessibility and Binding Strength of SARS-CoV-2 Spike Protein to Human Angiotensin-Converting Enzyme 2	Peng,  C,  Zhu, et al	J Phys Chem Lett	Coronavirology| Coronavirologie	We calculated the binding affinities of the RBDs to ACE2 and simulated the transitions between ACE2-inaccessible and -accessible conformations. We found that the ACE2-accessible angle of CoV-2-S is 52.2° and that the ACE2 binding strength of CoV-2-S RBD is much stronger than that of CoV–S RBD. However, CoV-2-S has much less of an ACE2-accessible conformation and is much more difficult to shift from ACE2-inaccessible to -accessible than CoV–S, making the binding affinity of the entire protein decrease. Further analysis revealed key interactional residues for strong binding and five potential ligand-binding pockets for drug research.
Early versus late acute kidney injury among patients with COVID-19-a multicenter study from Wuhan, China	Peng,  S,  Wang, et al	Nephrol Dial Transplant	Epidemiology| Épidémiologie Clinical data| Données cliniques	A total of 4020 cases with laboratory-confirmed COVID-19 were included and 285 (7.09%) of them were identified as Acute kidney injury (AKI). Compared with patients with AKI-early, patients with AKI-late had significantly higher levels of systemic inflammatory markers. Both AKIs were associated with an increased risk of in-hospital mortality, with similar fully adjusted hazard ratios of 2.46 [95% confidence interval (CI) 1.35–4.49] for AKI-early and 3.09 (95% CI 2.17–4.40) for AKI-late. Only hypertension was independently associated with the risk of AKI-early. While age, history of chronic kidney disease and the levels of inflammatory biomarkers were associated with the risk of AKI-late.
PMC7709478; Nonlinear model predictive control with logic constraints for COVID-19 management	Péni,  T,  Csutak, et al	Nonlinear Dyn	Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de sant&amp;eacute; publique	In this paper, we propose a model predictive approach for the constrained control of a nonlinear compartmental model that captures the key dynamical properties of COVID-19.
Application of 3D printing and distributed manufacturing during the first-wave of COVID-19 pandemic. Our experience at a third-level university hospital	Perez-Mañanes,  Ruben,  de San José, et al	Research Square prepub	Healthcare Response | Réponse des soins de santé	We present a monocentric observational case study regarding the distributed manufacturing of three groups of products during the period of the COVID-19 pandemic from 14 March to 10 May 2020: personal protective equipment, ventilatory support, and diagnostic and consumable products.
Neutrophil more than platelet activation associates with thrombotic complications in COVID-19 patients	Petito,  E,  Falcinelli, et al	J Infect Dis	Epidemiology| Épidémiologie Clinical data| Données cliniques	We analyzed platelet and neutrophil activation in COVID-19 patients and their association with venous thromboembolism (VTE). 6 COVID-19 patients and 31 healthy controls were studied; 8/36 COVID-19 patients (22.2%) developed VTE. Platelets and neutrophils were activated in COVID-19 patients. neutrophil extracellular traps (NETs), but not platelet activation, biomarkers correlated with disease severity and were associated with thrombosis. Plasmatic MMP-9 was significantly increased in COVID-19 patients. Platelet and neutrophil activation markers, but less so NETs, normalized after recovery. In vitro, plasma from COVID-19 patients triggered platelet and neutrophil activation and NET formation, the latter blocked by therapeutic dose low-molecular weight heparin, but not by aspirin or dypiridamole.
Maternal distress/coping and children’s adaptive behaviors during the covid-19 lockdown: Mediation through children’s emotional experience	Petrocchi,  S,  Levante, et al	Frontiers in Public Health	Mental Health | santé mentale	The present study focused on the psychological impact that the lockdown due to coronavirus disease-19 (COVID-19) had on families in Italy.  The present study tested if maternal distress/coping predicts children’s behaviors during the COVID-19 lockdown, hypothesizing a mediation effect via children’s emotional experience. Participants were 144 mothers (Mage = 39.3, 25–52, SD = 5.6) with children aged 5–10 years (Mage = 7.54, SD = 1.6, 82 boys); mothers answered to an online survey. Results indicated that mothers with higher exposure to COVID-19 showed higher levels of distress and higher display of coping attitudes, even if in the structural equation modeling model, the COVID-19 exposure was not a predictor of mothers’ distress. Compared with mothers with good coping skills, mothers with higher stress levels were more likely to attribute negative emotions to their children at the expense of their positive emotions. Moreover, children’s emotions acted as mediators between maternal distress/coping and children’s adaptive/maladaptive behaviors.
Asymptomatic COVID-19 Infection Detected on 18F-FDG PET/CT Scan Done for Multiple Myeloma	Pillenahalli Maheshwarappa,  R,  Graham, et al	Clin Nucl Med	Clinical data| Données cliniques	A 69-year-old woman with multiple myeloma came to our department for F-FDG PET/CT scan for routine surveillance. The patient denied any history of fever, cough, shortness of breath, or body aches. F-FDG PET/CT scan from vertex to knees was performed. PET/CT images revealed extensive peripheral ground-glass opacities showing intense FDG uptake (SUVmax 12) involving bilateral lower lobes. Possibility of an infective etiology including novel coronavirus (COVID-19) infection was raised. The patient's oropharyngeal swab for COVID-19 by polymerase chain reaction amplification test came back positive for COVID-19 infection. The patient and her husband were advised home quarantine for 14 days.
Residual SARS-CoV-2 RNA in nasal swabs of convalescent COVID-19 patients: Is prolonged quarantine always justified?	Piralla,  A,  Ricchi, et al	International Journal of Infectious Diseases	Epidemiology| Épidémiologie	In this prospective multicenter study, virus isolation was prospectively attempted in 387 nasal swabs from clinically recovered patients showing low viral load. Overall, a cytopathic effect was detected in nine samples, corresponding to a culture positivity rate of 2.3% (9/387).
Lockdown policies and the dynamics of the first wave of the Sars-CoV-2 pandemic in Europe	Plümper,  T,  Neumayer, et al	Journal of European Public Policy	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	This paper follows European countries as they struggled through the first wave of the Sars-CoV-2 pandemic. We analyze when countries were confronted with the virus, how long it took until the number of new infections peaked and at what level of infections that peak was achieved via social distancing and lockdown policies. We find that countries in which the virus made significant landfall later in time enjoyed a latecomer advantage that some of these countries squandered, however, by not responding quickly enough and that an early lockdown was more effective than a hard lockdown.
Impact of Doxycycline on COVID-19 Patients with Risk Factors: DYNAMIC, a Multi-Centre, Randomised, Placebo-Controlled, Double-Blind Trial	Poinas,  Alexandra,  Boutoille, et al	Research Square prepub	RCT	The trial will involve 330 patients who are positive for SARS-CoV-2 infection and have one or more risk factors for worsening the disease. These patients will be included in six hospitals covering the whole of France. For 14 days they will be given either 200mg of doxycycline a day or a placebo. Our hypothesis is a considerable reduction in the number of patients hospitalised due to COVID-19 thanks to the treatment of doxycycline.
No man is an island: Psychological underpinnings of prosociality in the midst of the COVID-19 outbreak	Politi,  E,  Van Assche, et al	Personality and Individual Differences	Mental Health | santé mentale	In our empirical contribution, we framed collective resilience and cohesion in terms of prosociality. A study carried out in the midst of the COVID-19 outbreak in the UK (N = 399) articulated basic individual values, ideological orientations (i.e., authoritarianism and social dominance orientation), and core political values in a comprehensive framework to predict bonding and bridging forms of prosocial intentions, and prosocial behaviors directed towards vulnerable groups. According to our findings, people whose worldview incorporates collective and collaborative principles cared more about others' welfare.
A holistic approach for suppression of COVID-19 spread in workplaces and universities	Poole,  SarahF,  Gronsbell, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de sant&amp;eacute; publique	In this paper, we introduce an epidemiological model (the “Community-Workplace” model) that accounts for SARS-CoV-2 transmission within the workplace, within the surrounding community, and between them. We use this multi-group deterministic compartmental model to consider various testing strategies that, together with symptom screening, exposure tracking, and nonpharmaceutical interventions (NPI) such as mask wearing and social distancing, aim to reduce disease spread in the workplace.
A Survey for Examining the Effects of COVID-19 and Infection Control Measures in Older Persons With Mild Cognitive Impairment and Dementia and Their Caregivers	Porcari,  DE,  Palmer, et al	Frontiers in Psychiatry	Public Health response| Interventions de santé publique	We develop two versions (i.e., patients and informants/caregivers) of a survey designed to assess the impact of the COVID-19 pandemic during the first Italian lockdown period (11 March −4 May 2020) on Memory Clinic outpatients with Mild Cognitive Impairment (MCI) or dementia, and their caregivers.
Telemedicine as a medical examination tool during the Covid-19 emergency: The experience of the onco-haematology center of tor vergata hospital in Rome	Postorino,  M,  Treglia, et al	International Journal of Environmental Research and Public Health	Healthcare Response | Réponse des soins de santé	Our retrospective study aimed to assess the widespread use of telemedicine in terms of feasibility and safety related to adverse events, a crucial experience which will make it possible to predict any effective use of such a method in patients with hematological disorders even after the end of the Covid-19 emergency.
PMC7528904; COVID-19 and Radiology Resident Imaging Volumes-Differential Impact by Resident Training Year and Imaging Modality	Poyiadji,  N,  Klochko, et al	Acad Radiol	Healthcare Response | Réponse des soins de santé	The purpose of this study was to assess the differential impact the pandemic had on radiology resident imaging volumes by training year and imaging modality. Overall percent decline in resident imaging interpretation volume from the prepandemic to intrapandemic time period was 62.8%. R1s and R2s had the greatest decline at 87.3% and 64.3%, respectively.
Increased mortality and worse cardiac outcome of acute myocardial infarction during the early COVID-19 pandemic	Primessnig,  U,  Pieske, et al	ESC Heart Fail	Healthcare Response | Réponse des soins de santé	This study aimed to evaluate the impact of coronavirus disease 2019 (Covid‐19) outbreak on admissions for acute myocardial infarction (AMI) and related mortality, severity of presentation, major cardiac complications and outcome in a tertiary‐care university hospital in Berlin, Germany. During the early phase of the Covid‐19 pandemic (e‐COV) in Berlin (March and April 2020), admissions for AMI halved compared with those in the pre‐Covid‐19 time (January and February 2020; pre‐COV) and with those in the corresponding months in 2019. However, mortality for AMI increased substantially from 5.2% pre‐COV to 17.7% (P < 0.05) during e‐COV.
Prophylactic intranasal administration of a TLR2/6 agonist reduces upper respiratory tract viral shedding in a SARS-CoV-2 challenge ferret model	Proud,  PC,  Tsitoura, et al	EBioMedicine	Therapeutics| Thérapeutique Animal model | Modèle animal	We show that prophylactic intra-nasal administration of the TLR2/6 agonist INNA-051 in a SARS-CoV-2 ferret infection model effectively reduces levels of viral RNA in the nose and throat. After 5 days post-exposure to SARS-CoV-2, INNA-051 significantly reduced virus in throat swabs (p=<0.0001) by up to a 24 fold (96% reduction) and in nasal wash (p=0.0107) up to a 15 fold (93% reduction) in comparison to untreated animals.
Vaccine acceptance among college students in South Carolina: Do information sources and trust in information make a difference?	Qiao,  Shan,  Friedman, et al	medRxiv	Public Health response| Interventions de santé publique	In September 2020, we conducted an online survey among 1062 college students in South Carolina to understand their perceptions and attitudes toward COVID-19 vaccination. The top three sources of COVID-19 vaccine information were health agencies (57.7%), mass media (49.5%), and personal social networks (40.5%). About 83.1% of the participants largely or always trusted scientists, 73.9% trusted healthcare providers, and 70.2% trusted health agencies.
Smartphone-based electrochemical sensor for assessing COVID-19 infected patients	R,  GB,  A, et al	International Journal of Pervasive Computing and Communications	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The purpose of the study is to highlight the potential of the sensor based smartphone in assessing the covid-19 cases. An electrochemical sensor-enabled smartphone has been developed to assess the COVID-19 infected patients. The data-enabled smartphone uses the Internet of Things (IoT) to share the details with the other devices. The electrochemical sensor enables the smartphone to evaluate the ribonucleic acid (RNA) of COVID-19 without the nucleic acid and feeds the data into the data server by using a smartphone. The developed electrochemical sensor-enabled smartphone gives an accuracy of 81% in assessing the COVID-19 cases.
Management strategies in a SEIR-type model of COVID 19 community spread	Rǎdulescu,  A,  Williams, et al	Sci Rep	Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de sant&amp;eacute; publique	In our work, we adapt a traditional SEIR epidemic model to the specific dynamic compartments and epidemic parameters of COVID 19, as it spreads in an age-heterogeneous community. We analyze management strategies of the epidemic course (as they were implemented through lockdown and reopening procedures in many of the US states and countries worldwide); however, to more clearly illustrate ideas, we focus on the example of a small scale college town community, with the timeline of control measures introduced in the state of New York.
Determinants of soluble angiotensin-converting enzyme 2 concentrations in adult patients with complex congenital heart disease	Raedle-Hurst,  T,  Wissing, et al	Clin Res Cardiol	Epidemiology| Épidémiologie Clinical data| Données cliniques	In a total of 182 consecutive adult patients with complex congenital heart disease (CHD) and 63 healthy controls, sACE2 concentrations were measured in serum using the Human ACE2® assay by Cloud-Clone Corporation and associated with clinical, laboratory and echocardiographic parameters. Median sACE2 levels were increased in patients with complex CHD as compared to healthy controls (761.9 pg/ml vs 365.2 pg/ml, p < 0.001). Moreover, sACE2 concentrations were significantly elevated in patients with a higher NYHA class ≥ III (1856.2 pg/ml vs 714.5 pg/ml in patients with NYHA class I/II, p < 0.001).
ABO / Rh-D blood types and susceptibility to corona virus disease-19 in Peshawar, Pakistan	Rahim,  F,  Amin, et al	Pakistan Journal of Medical Sciences	Epidemiology| Épidémiologie	We aim to determine the association between ABO/Rh-D blood types and susceptibility to SARS-CoV-2 infection in Pakistan. Significantly higher proportion of blood type-B was observed in COVID-19 group (35.9% vs 31.9%, p=0.009). Blood type-AB was found more frequently (14.2% vs 11.8%, p=0.03) in the comparison group. The Rh-D Positive blood types were 93.3% in COVID-19 group and 94.9% in comparison group (p=0.03).
Exploring the Effect of Image Enhancement Techniques on COVID-19 Detection using Chest X-rays Images	Rahman,  Tawsifur,  Khandakar, et al	arXiv	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	This paper explores the effect of various popular image enhancement techniques and states the effect of each of them on the detection performance. We have compiled the largest X-ray dataset called COVQU-20, consisting of 18,479 normal, non-COVID lung opacity and COVID-19 CXR images. To the best of our knowledge, this is the largest public COVID positive database. The accuracy, precision, sensitivity, f1-score, and specificity in the detection of COVID-19 with gamma correction on CXR images were 96.29%, 96.28%, 96.29%, 96.28% and 96.27% respectively. The accuracy, precision, sensitivity, F1-score, and specificity were 95.11 %, 94.55 %, 94.56 %, 94.53 % and 95.59 % respectively for segmented lung images. The proposed approach with very high and comparable performance will boost the fast and robust COVID-19 detection using chest X-ray images.
COVID-19 and infection control in dental clinics; assessment of public knowledge, attitudes and practices in several regions of Saudi Arabia	Rajeh,  M	Open Dentistry Journal	Public Health response| Interventions de santé publique	The aim of this study was to assess the level of public knowledge, attitude and practice regarding COVID-19 and infection control when visiting a dentist. Most Saudi residents with a high education level are knowledgeable about COVID-19, hold promising attitudes, and have appropriate practices towards precautionary measures needed while visiting a dental clinic during the virus outbreak.
Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity	Ramaswamy,  Anjali,  Brodsky, et al	medRxiv	Immunology | Immunologie	Here, we define immune abnormalities in MIS-C compared to adult COVID-19 and pediatric/adult healthy controls using single-cell RNA sequencing, antigen receptor repertoire analysis, unbiased serum proteomics, and in vitro assays. Despite no evidence of active infection, we uncover elevated S100A-family alarmins in myeloid cells and marked enrichment of serum proteins that map to myeloid cells and pathways including cytokines, complement/coagulation, and fluid shear stress in MIS-C patients.
Paediatric COVID-19: Milder Presentation-A Silver Lining in Dark Cloud	Ramteke,  S,  Tikkas, et al	J Trop Pediatr	Epidemiology| Épidémiologie Clinical data| Données cliniques	We assess the clinico-epidemiological profile of paediatric patients with Corona virus disease 2019 (COVID-19) infection during the pandemic. A total of 30 children with median age of 10.5 years (8 months to 14 years) were included in the present study. Sixty percent were boys. Twenty-seven (90%) belonged to an urban area and all 30 children were from a containment area. All were belonging to Kuppuswamy upper lower and lower socioeconomic class. Twenty-one (70%) were asymptomatic.
How do the public interpret COVID-19 swab test results? Comparing the impact of official information about results and reliability used in the UK, US and New Zealand: a randomised, controlled trial	Recchia,  Gabriel,  Schneider, et al	medRxiv	Public Health response| Interventions de santé publique RCT	To assess the effects of different official information on public interpretation of a personal COVID-19 PCR (‘swab’) test result. Participants were asked “What is your best guess as to the percent chance that John actually had COVID-19 at the time of his test, given his result?”; questions about their feelings of trustworthiness in the result, their perceptions of the quality of the underlying evidence, and what action they felt ‘John’ should take in the light of his result. Participants rated positive test results more trustworthy and higher quality of evidence than negative results.
Insulin Use, Diabetes Control, and Outcomes in Patients with COVID-19	Riahi,  S,  Sombra, et al	Endocr Res	Epidemiology| Épidémiologie	In this single-center, retrospective observational study, all adult patients admitted to Einstein Medical Center, Philadelphia, from March 1 through April 24, 2020 with a diagnosis of COVID-19 and diabetes were included. Demographic, clinical and laboratory data, insulin dose at home and at the hospital, other anti-hyperglycemic agents use, and outcomes were obtained. Multivariate logistic regression was used to evaluate the factors associated with diabetes control and mortality. Among diabetic patients infected with COVID-19, insulin therapy at home was significantly independently associated with increased mortality.
A first-in-human evaluation of the safety and immunogenicity of SCB-2019, an adjuvanted, recombinant SARS-CoV-2 trimeric S-protein subunit vaccine for COVID-19 in healthy adults; a phase 1, randomised, double-blind, placebo-controlled trial	Richmond,  Peter,  Hetchual, et al	medRxiv	Vaccine Research| Recherche sur les vaccins RCT	We report a first-in-human dose-finding and adjuvant justification study of SCB-2019, a novel protein subunit vaccine candidate composed of a stabilised trimeric form of the spike (S)-protein produced in CHO-cells, combined with two different adjuvants. We report on 148 participants with at least 4 weeks follow-up post dose 2. Three participants withdrew, two for personal reasons and one with an unrelated SAE (pituitary adenoma). Vaccination was well tolerated, with few Grade 3 solicited adverse events (AE).
Telogen effluvium related to post severe Sars-Cov-2 infection: Clinical aspects and our management experience	Rizzetto,  G,  Diotallevi, et al	Dermatologic Therapy	Clinical data| Données cliniques	We report three cases of Telogen effluvium (TE) occurred after severe Sars‐Cov‐2 infection and provide our clinical management, according to Sars‐Cov‐2 hygiene measures. Only one case report has been found in the literature associating anagen effluvium during severe Sars‐Cov‐2 infection.
PMC7709477; Identification of Functional Limitations and Discharge Destination in COVID-19 Patients	Roberts,  P,  Wertheimer, et al	Arch Phys Med Rehabil	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objectives of this study were to identify functional limitations in COVID-19 patients admitted to acute care hospitals, to evaluate functional limitations by demographic, medical and encounter characteristics, and to examine functional limitations in relation to discharge destination. A total of 273 cases were identified, which included 230 cases that were discharged alive and 43 patients who expired and were excluded from the study sample. This research highlights that functional status is a strong predictor for discharge destination to an institution for COVID-19 patients.
Explaining the rise and fall of psychological distress during the COVID-19 crisis in the United States: Longitudinal evidence from the Understanding America Study	Robinson,  E,  Daly, et al	Br J Health Psychol	Mental Health | santé mentale	The aim of the current study was to investigate psychosocial and behavioural factors that may explain the rise and fall of distress during the initial months of the COVID‐19 crisis. This study provides longitudinal population‐based evidence detailing the mediating factors explaining changes in distress during the COVID‐19 crisis.
Viscoelastic tests in the evaluation of haemostatic disorders in SARS-CoV-2 infection	Rodrigues,  A,  Seara Sevivas, et al	Acta Medica Portuguesa	Clinical data| Données cliniques	Viscoelastic tests are very useful tools to assess hypercoagulability and hypofibrinolysis (not detectable by standard coagulation tests) in critically ill SARS-CoV-2 patients with COVID-19 associated coagulopathy and look like very promising tools for anticoagulation management. However, further research needs to be carried out to determine whether abnormal viscoelastic tests alone or in combination with other clinical or laboratory findings can identify patients at increased thrombotic risk. Clinical trials to evaluate hypercoagulability using viscoelastic tests and the need for personalized dosage of anticoagulation in SARS-CoV-2 patients are quickly emerging.
Deep Learning Audio Spectrograms Processing to the Early COVID-19 Detection	Rodriguez,  CR,  Angeles, et al		Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The objective of the paper is to provide a model capable of serving as a basis for retraining a convolutional neural network that can be used to detect COVID-19 cases through spectrograms of coughing, sneezing and other respiratory sounds from infected people. To address this challenge, the methodology was focused on Deep Learning technics worked with a dataset of sounds of sick and non-sick people, and using ImageNet's Xception architecture to train the model to be presented through Fine-Tuning. The results obtained were a precision of 0.75 to 0.80, this being drastically affected by the quality of the dataset at our availability, however, when getting relatively high results for the conditions of the data used, we can conclude that the model can present much better results if it is working with a dataset specifically of respiratory sounds of COVID-19 cases with high quality.
Horizontal SARS-COV-2 infection in three newborns: We can also avoid unnecessary irradiation	Rodríguez-Fanjul,  J,  Nicolás, et al	Anales de Pediatria	Clinical data| Données cliniques	We present three neonates seen in our Pediatric Service with SARS-CoV-2 infection. The clinical and analytical data of the patients are given.
Impact of outbreak COVID-19 pandemic on psychiatry emergencies in Spain	Rodriguez-Jimenez,  R,  Rentero, et al	Psychiatry research	Mental Health | santé mentale Healthcare Response | Réponse des soins de santé	A retrospective cross-sectional study was designed with the aim to evaluate psychiatric emergencies from March 14 to May 1, 2020, coinciding with the start of the emergency state and the lockdown until the attenuation of the confinement. Data obtained during this period were compared with the emergencies attended in the same period of 2019. A total of 213 psychiatric emergencies were attended in 2020 compared with 367 in 2019.
Mechanical ventilation and mortality among 223 critically ill patients with coronavirus disease 2019: A multicentric study in Germany	Roedl,  K,  Jarczak, et al	Australian Critical Care	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim was to investigate the characteristics and outcomes of critically ill patients with COVID-19 requiring intensive care unit (ICU) admission and MV. A total of 223 critically ill patients with COVID-19 were included. The majority, 73% (n = 163), were men; the median age was 69 (interquartile range = 58–77.5) years, with 68% (n = 151) patients having at least one chronic medical condition.
Associations between COVID-19-Related Digital Health Literacy and Online Information-Seeking Behavior among Portuguese University Students	Rosário,  R,  Martins, et al	Int J Environ Res Public Health	Public Health response| Interventions de santé publique	We aim to evaluate the associations between digital health literacy (DHL) related to COVID-19 and online information-seeking behavior among university students. Methods: A total of 3.084 students (75.7% women), with an average age of 24.2 (SD = 7.5) participated in this cross-sectional study, most of whom (36.5%) were from social sciences and pursued a bachelor’s degree (50.7%).
Early experiences of establishing telemedicine in the radiotherapy physics department at the time of the COVID-19 outbreak: When less staff is more effective	Rostami,  A,  Akbari, et al	Informatics in Medicine Unlocked	Healthcare Response | Réponse des soins de santé	In this paper, the impact of the remote access implementation strategy on the number of patients admitted for treatment and the physical presence time of the physicists in the department of medical physics of a radiotherapy center at the time of COVID-19 outbreak were evaluated.
Mass SARS-CoV-2 serological screening for the Principality of Andorra	Royo-Cebrecos,  Cristina,  Vilanova, et al	Research Square prepub	Epidemiology| Épidémiologie Immunology | Immunologie	We estimated SARS-CoV-2 seroprevalence in the entire country by universal serological testing. From 4–28 May, 2020 two cross sectional serological surveys were conducted using a rapid serological test (nCOV IgG/IgM). 72,964 inhabitants (96.1% of the population) participated. Overall seroprevalence was 11.0%.
Epidemiology and public health response in early phase of COVID-19 pandemic, Veneto Region, Italy, 21 February to 2 April 2020	Russo,  F,  Pitter, et al	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	The objectives of this paper are to describe: (i) the Veneto Region’s early public health response from the start of the outbreak and (ii) the epidemiology of SARS-CoV-2 infections in the Veneto Region as at 2 April 2020.
Clinicians’ User Experience of Telemedicine in Neurosurgery During COVID-19	Ryu,  WHA,  Kerolus, et al	World Neurosurgery	Healthcare Response | Réponse des soins de santé	This study aimed to characterize user experiences of neurosurgeons and advanced practice providers focusing on perceived utility and barriers of telemedicine in management of elective neurosurgical patients during COVID-19. The survey was completed by 14 of 17 eligible clinicians. During the COVID-19 period, 78% of respondents used teleconference/video conference visits multiple times in a week, and 86% planned to continue using telemedicine after the pandemic. The most common barrier for telemedicine was the inability to perform a neurological examination, while the most common perceived benefit was increased convenience for patients.
PMC7710468; Systemic microvascular endothelial dysfunction and disease severity in COVID-19 patients: Evaluation by laser Doppler perfusion monitoring and cytokine/chemokine analysis	Sabioni,  L,  De Lorenzo, et al	Microvasc Res	Clinical data| Données cliniques	We investigate if microvascular dysfunction, serum cytokines and chemokines may play an important roles in pathophysiology of coronavirus disease 2019 (COVID-19), especially in severe cases. In patients with COVID-19, especially with S-COVID, endothelium-dependent microvascular vasodilator responses are reduced, while serum cytokines and chemokines involved in the regulation of vascular function and inflammation are increased.
Using Whatsapp for the Consultation of Covid-19 Suspected Patients in Pandemic Polyclinics; A Retrospective Case Control Study	Sabırlı,  R,  Karsli, et al	JMIR Mhealth Uhealth	Healthcare Response | Réponse des soins de santé	Investigate the effect of Whatsapp video consultation upon patient admission and discharge times in comparison to bedside consultation in the evaluation of potential Covid-19 patients visiting the Covid-19 outpatient clinic during the pandemic period.
CT findings of 795 COVID-19 positive cases: a multicenter study in Egypt	Sabri,  YY,  Fawzi, et al	Egyptian Journal of Radiology and Nuclear Medicine	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Analyze the chest CT findings of patients diagnosed with COVID-19 admitted to hospitals in Egypt. Normal CT “negative for COVID-19” was reported in 26.1% in confirmed cases. Imaging findings of the positive CT cases (73.9%) included GGO (69%), consolidation (49.7%), crazy paving (15.4%), and peri-lobular fibrosis (40.6%). These showed a dominantly bilateral (68.2%), peripheral (72.4%), and patchy (64.7%) distribution.
Can we predict who will be more anxious and depressed in the COVID-19 ward?	Şahan,  E,  Ünal, et al	Journal of psychosomatic research	Mental Health | santé mentale	Explore the anxiety and depression levels, prevalence and predictors in patients hospitalized with COVID-19 (n=281). Female gender, staying alone in a hospital room, early days of hospital stay, and any lifetime psychiatric disorder was associated with symptoms of anxiety. Being over 50 years of age, staying alone in a hospital room, and NSAID use before the week of hospital admission were associated with symptoms of depression. Anxiety and depression levels were lower when family members who tested positive for COVID-19 stayed in the same hospital room during treatment.
PMC7670966; Molecular interaction analysis of Sulawesi propolis compounds with SARS-CoV-2 main protease as preliminary study for COVID-19 drug discovery	Sahlan,  M,  Irdiani, et al	J King Saud Univ Sci	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Aimed to examine whether Sulawesi propolis compounds produced by Tetragonula sapiens inhibit the enzymatic activity of SARS-CoV-2 main protease, via molecular docking. Glyasperin A and broussoflavonol F, are potential drug candidates for COVID-19 based on their binding affinity.
Exponential spread of covid-19 pandemic in Europe and america - a public perception survey	Saivarshine,  S,  Lakshmanan, et al	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	This study analysed the statistics on the knowledge among the public about reasons for exponential spread of covert 19 pandemic in Europe and America and a majority of population were of the opinion that prompt government action and policies can save lives.
The “stay at home” orders effect on mental health of Egyptian adults during the COVID-19 pandemic partial lockdown	Saleh,  MS	International Journal of Human Rights in Healthcare	Mental Health | santé mentale	More than 70% of respondents declared jobs being affected by the pandemic. Females showed deteriorated state of mental health, together with the youth (≤44 years) and those who lost their jobs or suffered reduced income. In conclusion, mental health as expressed by MW and stress showed to be affected among the Egyptian adults due to the “stay at home” orders.
Using hybrid telepractice for supporting parents of children with asd during the COVID-19 lockdown: A feasibility study in Iran	Samadi,  SA,  Bakhshalizadeh-Moradi, et al	Brain Sciences	Healthcare Response | Réponse des soins de santé	A low dropout rate and positive feedback from parents indicated that they perceived telepractice sessions to be useful. Although the use of telepractice would be a good alternative for caregivers in any future lockdowns, it could also be used in conjunction with daycare center services to encourage greater parental participation, or with families living in areas with no day centers.
Spectrum of HRCT findings among asymptomatic and recovered COVID-19 patients: how did they impact the clinical decision?	Samir,  A,  Abdelgawad, et al	Egyptian Journal of Radiology and Nuclear Medicine	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	HRCT was analyzed by three expert consultant radiologists in consensus. Among asymptomatic initially screened COVID-19 patients, additional to GGOs, bilateral consolidative changes were unexpectedly found together with secondary fibrosis (23.3% and 10%). HRCT results significantly impacted the clinical decision (P < 0.0001)
Prediction of end of lockdown post-peak of cases in first wave of the COVID-19 pandemic in Chile	San Martín-Roldán,  D,  Rojo-Lazo, et al	Medwave	Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de sant&amp;eacute; publique	Analysis based on based on a trend model with prediction estimation. Gradual and cautious steps should be taken before ending mandatory confinement. In the current de-escalator, daily PCR tests should be increased, maintaining vigilance on indicators of incidence, prevalence, and positivity of PCR tests. Evidence suggests with some degree of confidence that mandatory confinement could be safely lifted as of August 30, 2020.
Effects of COVID-19 pandemic on emergency medical services	Şan,  İ,  Usul, et al	Int J Clin Pract	Healthcare Response | Réponse des soins de santé	There was a statistically significant difference between pre‐pandemic and pandemic period in terms of rural area case frequency in Ankara province India. During the pandemic period, case frequency of angina pectoris (‐35.2%), myocardial infarction (‐45%), acute abdomen (‐23.8%), and cerebrovascular diseases (‐2.9%) decreased contrary to pre‐pandemic period (2019). During the same period, symptoms of fever (+ 14.1%) and cough (+ 956.3%) increased.
Do psychological strengths protect college students confined by COVID-19 to emotional distress? The role of gender	Sánchez-Teruel,  D,  Robles-Bello, et al	Personality and Individual Differences	Mental Health | santé mentale	The results obtained show that both variables related to the family unit and psychosocial protective variables explain 28.6% of the variance in general distress in the total sample
Awareness and knowledge of hydroxychloroquine among public	Sankari Niveditha,  A,  Arivarasu, et al	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	The aim of the study is to create awareness and knowledge of Hydroxychloroquine among the general public. 91% of people agreed that hydroxychloroquine along with common antibiotics can be used for the treatment of COVID 19. 43% of people are aware of the contraindications of the drug.
Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020	Santos-Hövener,  C,  Neuhauser, et al	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	Three months after a coronavirus disease (COVID-19) outbreak in Kupferzell, Germany, a population-based study (n = 2,203) found no RT-PCR-positives. IgG-ELISA seropositivity with positive virus neutralisation tests was 7.7% (95% confidence interval (CI): 6.5-9.1) and 4.3% with negative neutralisation tests. The study supports full hotspot containment to be an effective and prompt protection measures.
COVID-19 Lung CT Image Segmentation Using Deep Learning Methods: UNET Vs. SegNET	Saood,  Adnan,  Hatem, et al	Research Square prepub	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Compare the use two known deep learning networks, SegNet and UNET, for image tissue classification from CT scans. Superior ability of SegNet in classifying infected/non-infected tissues compared to the other methods is reported.
Evaluation of electrolyte status of sodium, potassium and magnesium, and fasting blood sugar at the initial admission of individuals with COVID-19 without underlying disease in Golestan Hospital, Kermanshah	Sarvazad,  H,  Cahngaripour, et al	New Microbes and New Infections	Clinical data| Données cliniques	Examined electrolyte imbalance and blood sugar levels in patients with COVID-19 who had no underlying disease in Kermanshah, west of Iran. Among included patients, 49.1% hyperglycemia, 38% hyponatremia, 7.3% hypokalemia, and 32% hypomagnesemia were observed. In contrast to age and the level of K+, there were statistically significant differences between the outpatient and ICU groups in terms of Mg2+, Na+, and FBS (p < 0.05). Study finds hyperglycemia and electrolyte imbalance in COVID-19 patients is feasible.
Investigating ion transport inside the pentameric ion channel encoded in COVID-19 e protein	Saurabh,  K,  Solovchuk, et al	Physical Review E	Coronavirology| Coronavirologie	Attempt to understand the selectivity and the current voltage relation of the COVID-19 E protein pentameric ion channel, considering two ionic species, Na+ and Cl-.
Sustained SARS-CoV-2 nucleocapsid antibody levels in nonsevere COVID-19: A population-based study	Schaffner,  A,  Risch, et al	Clinical Chemistry and Laboratory Medicine	Coronavirology| Coronavirologie Immunology | Immunologie	Investigate the longitudinal course of antibody levels of various isotypes against S protein or N antigen in a population-based cohort, which included all 95 confirmed COVID-19 cases.  The study finds different patterns of antibody kinetics depend on the target antigen and antibody isotypes. IgA and IgG against the SARS-CoV-2 S-protein show a decrease; however, the total antibody levels directed against the SARS-CoV-2 N-antigen remain stable despite a decrease in SARS-CoV-2 N-antigen IgG.
MTX-COVAB, a human-derived antibody with potent neutralizing activity against SARS-CoV-2 infection in vitro and in a hamster model of COVID-19	Schmitt,  Simone,  Weber, et al	bioRxiv	Coronavirology| Coronavirologie Animal model | Modèle animal	MTX-COVAB shows strong efficacy in vivo and binds to all currently identified clinically relevant variants of SARS-CoV-2.
The COVID-19 burden for health care professionals: Results of a global survey	Schneider,  M,  Altersberger, et al	European journal of internal medicine	Healthcare Response | Réponse des soins de santé	An online survey targeting the worldwide medical community (emergency medical service, nurses, physicians, sonographers, technicians) to discover experiences, fears, and successful strategies for the expected second wave. A total of 3,090 participants from 88 countries completed the survey, 49.4% were female, During the worst times of the pandemic in their country, 238 (7.7%) reported to have suffered from a collapse of the system.
Genetic variability in COVID-19-related genes in the Brazilian population	Secolin,  Rodrigo,  de Araujo, et al	bioRxiv	Coronavirology| Coronavirologie	Investigate the genetic variation present in COVID-19-related genes in the Brazilian population. Results showed genetic variability common to other populations, but also rare and ultra-rare variants exclusively found in the Brazilian population.
Sspopular perception on COVID-19 about being a bioengineered weapon- a survey	Selvapriya,  S,  Lakshmanan, et al	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	An online survey was conducted with a self structured questionnaire comprising 10 questions about the facts and claims of Covid-19 as a lab made bio weapon. 82.1% are of the perception that Covid-19 is a lab made bio weapon and among them 80.2% of participants think Covid-19 is Chinese bio weapon.
Monitoring stroke rehabilitation re-learning program using EEG parameter: A preliminary study for developing self-monitoring system for stroke rehabilitation during new normal	Setiawan,  AF,  Wibawa, et al		Healthcare Response | Réponse des soins de santé	Study of 3 stroke patients who underwent stroke rehabilitation using re-learning program during the COVID-19 pandemic.
Transition to telephone genetic counseling services during the COVID-19 pandemic	Shannon,  KM,  Emmet, et al	J Genet Couns	Healthcare Response | Réponse des soins de santé	Compare differences in the six weeks following the shift to telephone genetic cancer counseling (post‐COVID) to the six weeks preceding the pandemic (pre‐COVID).  Conclude that a rapid transition to remote genetic counseling and testing allowed uninterrupted access to cancer genetics services during to the COVID‐19 pandemic. Patient compliance with sample return and higher rates of sample failure emerge as potential barriers to timely genetic testing under this service delivery model.
COVID-19 transmission in the first presidential debate in 2020	Shao,  X,  Li, et al	Physics of Fluids	Modelling/ prediction| Modélisation/prédiction Transmission	The infection probabilities at different positions were assessed by using the Wells-Riley equation with consideration of the effects of air distribution and face mask. It was concluded that (1) the infection risks of Biden and Wallace were lower due to the reasonable distance from Trump, with the maximum probability of 0.34% at 40 quanta/h for both Trump and the first lady being infected; (2) the infection probabilities in the audience area were lower for the long distance from the debate stage, with the maximum probability of 0.35%. Wearing masks resulted in a notable decrease in the infection probability to 0.09%; and (3) there was a certain local area surrounding Trump and the first lady with a relatively greater infection probability.
Determining crucial genes associated with COVID-19 based on COPD Findings✶,✶✶	Sharma,  P,  Pandey, et al	Computers in biology and medicine	Clinical data| Données cliniques Coronavirology| Coronavirologie	Uses gene module analysis and pathway information to determine the role of genes which may be associated with COVID-19 in COPD patients. Several crucial genes associated with COVID-19: RPA2, POLD4, MAPK8, IRF7, JUN, NFKB1, NFKBIA, CD40LG, FASLG, ICAM1, LIFR, STAT2 and CCR1. Most of these genes are related to the immune system and respiratory organs, which emphasizes the fact that COPD weakens this system and m
Breast reconstruction with immediate autologous free tissue transfer in a peri-operative COVID-19 positive patient: A case report illustrating feasibility of aftercare	Sharp,  O,  Masud, et al	Journal of Plastic, Reconstructive and Aesthetic Surgery	Clinical data| Données cliniques	Report on a 56-year-old woman who presented with recurrent left sided breast cancer, who tested positive for COVID-19.
Lung volume reduction and infection localization revealed in Big data CT imaging of COVID-19	Shi,  F,  Wei, et al	International Journal of Infectious Diseases	Clinical data| Données cliniques	CT images of 3389 COVID-19 patients, 1593 community-acquired pneumonia (CAP) patients, and 1707 nonpneumonia subjects were included to explore the different patterns of lung and lung infection. Found that COVID-19 patients have a significant reduced lung volume with increased density and mass, and the infections tend to present as bilateral lower lobes.
Efficacy and safety of Chinese herbal medicine versus Lopinavir-Ritonavir in adult patients with coronavirus disease 2019: A non-randomized controlled trial	Shi,  N,  Guo, et al	Phytomedicine	Therapeutics| Thérapeutique RCT	Randomised controlled trial, in which all adult patients with laboratory-confirmed COVID-19 were assigned to three groups non-randomly and given supportive treatments: Group A, Lopinavir-Ritonavir; Group B, Huashi Baidu Formula and Lopinavir-Ritonavir. Compared with Groups A and B, the clinical remission time of Group C was significantly shorter (5.9 days vs. 10.8 days, p < 0.05; 5.9 days vs. 9.7 days, p < 0.05). There was no significant difference among Groups A, B, and C in terms of the time taken to be released from quarantine. The clinical biochemical indicators and safety indexes showed no significant differences among the three groups.
EXAM: An Explainable Attention-based Model for COVID-19 Automatic Diagnosis	Shi,  W,  Tong, et al		Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Propose an Explainable Attention-based Model (EXAM) for COVID-19 automatic diagnosis with convincing visual interpretation. Transform the diagnosis process with radiological images into an image classification problem differentiating COVID-19, normal and community-Acquired pneumonia (CAP) cases.
Situation of India in the COVID-19 Pandemic: India's Initial Pandemic Experience	Siddiqui,  AF,  Wiederkehr, et al	Int J Environ Res Public Health	Public health interventions*| Interventions de sant&amp;eacute; publique Surveillance	Investigate the impact of COVID-19 through screening and surveillance methods adopted in India. Surveillance data was examined, initial containment measures, including point of entry screenings and testing protocols, appeared insufficient to control infection rates.
EP02 A rare case of reactive arthritis secondary to Covid-19	Sidhu,  A,  Selvan, et al	Rheumatology Advances in Practice	Clinical data| Données cliniques	Describe a 31-year-old female doctor who was admitted with acute swelling of her lips, dysphagia, and a widespread urticarial rash. Preceding this she had a one-week history of fever, cough, and constitutional symptoms of malaise and weight loss.
Galectin antagonist use in mild cases of SARS-CoV-2 cases; pilot feasibility randomised, open label, controlled trial	Sigamani,  Alben,  Sigamani, et al	medRxiv	Therapeutics| Thérapeutique RCT	Pilot study on the feasibility of performing a definitive trial of using galectin antagonist – Prolectin-M as treatment for mild, symptomatic, rRT-PCR positive, COVID-19.
Acute ischemia of the upper arm in COVID-19 patient	Siguënza,  VAH,  Pérez, et al	Angiologia	Clinical data| Données cliniques	Present a case of arterial thrombosis in a patient with COVID-19 and a systematic review on coagulopathy associated with COVID-19.
Physical Inactivity Is Associated With Increased Levels of Anxiety, Depression, and Stress in Brazilians During the COVID-19 Pandemic: A Cross-Sectional Study	Silva,  LRB,  Seguro, et al	Frontiers in Psychiatry	Mental Health | santé mentale	Evaluate the levels of anxiety, depression, and stress associated with the practice of physical exercise (PE) during pandemic by COVID. During the isolation period, the number of participants who declared not to exercise was 54.16%. Women generally presented higher levels of anxiety, depression, and stress when compared to men (p < 0.0001 for all domains). The risk of having increased anxiety were higher the risk of depression was higher, and the risk of stress symptoms increased 7in the participants who did not perform PE when compared to those who maintain regular PE.
Model for evaluating cost-effectiveness of surveillance testing for SARS-CoV2	Silver,  Jonathan	medRxiv	Modelling/ prediction| Modélisation/prédiction Economics | Économie	Testing people without symptoms for SARS-CoV-2 followed by isolation of those who test positive could mitigate the covid-19 epidemic pending arrival of an effective vaccine. A cost-effectiveness model that provides answers depending on user-adjustable parameter values is described. Key parameters are the value ascribed to preventing a death and the reproduction number (roughly, rate of spread) at the time surveillance testing is initiated.or current rates of spread, cost-effectiveness usually requires a value per life saved greater than $100,000 and depends critically on the extent and frequency of testing.
Impact of the COVID-19 pandemic on testing services for HIV, viral hepatitis and sexually transmitted infections in the WHO European Region, March to August 2020	Simões,  D,  Stengaard, et al	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin	Healthcare Response | Réponse des soins de santé	Preliminary results of a coronavirus disease (COVID-19) impact assessment on testing for HIV, viral hepatitis and sexually transmitted infections in the WHO European Region are presented.
Knowledge, attitude, and practices of healthcare workers in non-covid areas of the hospital regarding the use of face mask to limit the spread of the novel coronavirus disease (Covid-19): An institutional cross-sectional online survey	Singh,  AP,  Agrawal, et al	Journal of SAFOG	Healthcare Response | Réponse des soins de santé	The objective of this study was to assess whether a knowledge gap exists in the correct use of face masks, attitude, and practices of healthcare workers in wearing a face mask to limit the spread of COVID-19. Among the 136 respondents, 73.5% knew the correct steps in wearing a face mask, and their attitudes toward face masks were strongly positive. Further analyses showed that respondents were equally likely to wear a face mask at hospital or at non-hospital places. Moreover, two-thirds respondents reported to have some problems while wearing a mask.
Domestic harassment of women and children during COVID-19	Singh,  M	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	The aim of this study is to find out the nature and various causes of domestic violence against women during COVID-19's lockdown situation. Using standard questionnaire and random sampling, samples of 165 females from various sectors with varying educational qualifications and family status levels were surveyed.  Specific causes and character of domestic violence can be found in the COVID-19 case, such as oral bullying, abuse, physical abuse, assault, mistreatment, spouse's aggressive behavior and sexual abuse due in part to factors such as female identity, financial distress, domination, alcohol and extra-marital problems, etc
What is the difference on impact of day to day life in sars, mers and COVID-19 - a perceptional survey	Sitara,  S,  Lakshmanan, et al	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	The main aim of this online questionnaire study is to determine the comparative impact of day to day life in SARS, MERS and COVID-19.  Nearly 92.2% of participants were aware about the symptoms of SARS, MERS and COVID-19. Majority of participants were aware of the economic impact, social distancing and intensity of harm caused by COVID-19 than other epidemics. This study revealed that the majority of the population were aware about the difference on impact of these respiratory diseases on day to day life and graded the COVID -19 has the most impact comparatively.
The link between ego-resiliency, social support, SARS-CoV-2 anxiety and trauma effects. Polish adaptation of the Coronavirus Anxiety Scale	Skalski,  S,  Uram, et al	Personality and Individual Differences	Mental Health | santé mentale	The purpose of this study was to assess the relation between ego-resiliency, social support, coronavirus anxiety and trauma effects. Structural equation modeling indicated that ego-resiliency and social support were correlated and negatively predicted the severity of the novel coronavirus anxiety. Moreover, the level of anxiety showed positive correlation with negative trauma effects.
Clinical status and lung function 10 weeks after severe SARS-CoV-2 infection	Smet,  J,  Stylemans, et al	Respiratory medicine	Long-Term Sequelae | séquelles à long terme	Since studies about clinical status after COVID-19 are scarce, we conducted a cross sectional study of patients in Brussels with assessment of residual symptoms, lung function and chest CT. Fifty-four percent of COVID-19 survivors had abnormal lung function 10 weeks after diagnosis. Restriction was the most prevalent pulmonary function, with the more critically ill patients being more prone to this condition. Yet, restriction could not be linked with abnormal imaging results or residual symptoms.
Little to no expression of angiotensin-converting enzyme-2 (ACE2) on most human peripheral blood immune cells but highly expressed on tissue macrophages	Song,  X,  Hu, et al	Cytometry A	Clinical data| Données cliniques Immunology | Immunologie	Angiotensin-converting enzyme-2 (ACE2) has been recognized as the binding receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Flow cytometry demonstrated that there was little to no expression of ACE2 on most of the human peripheral blood-derived immune cells. Immunohistochemistry demonstrated high expressions of ACE2 on human tissue macrophages, such as alveolar macrophages, Kupffer cells within livers, and microglial cells in brain at steady state. The data suggest that alveolar macrophages may be directly targeted by the SARS-CoV-2 infection.
D-dimer level is a useful predictor for mortality in patients with COVID-19: Analysis of 483 cases	Soni,  M,  Gopalakrishnan, et al	Diabetes and Metabolic Syndrome: Clinical Research and Reviews	Epidemiology| Épidémiologie Clinical data| Données cliniques	We aimed to determine the association of D-dimer levels and mortality and to establish its optimal cut off values in predicting mortality. Information on 483 patients with confirmed COVID-19 was retrospectively collected and analyzed.Among the measured coagulation parameters, D-dimer during hospital stay had the highest C-index to predict in-hospital mortality in COVID-19 patients. D-dimer value ≥ 2.01 μg/mL can effectively predict in-hospital mortality in patients with COVID-19. A significant association of increased D-dimer level has been found with diabetes mellitus and elderly age.
PMC7700063; From information seeking to information avoidance: Understanding the health information behavior during a global health crisis	Soroya,  SH,  Farooq, et al	Inf Process Manag	Mental Health | santé mentale Public Health response| Interventions de santé publique	We propose a model to understand the effect of information seeking, information sources, and information overload (Stimuli) on information anxiety, and consequent behavioral response, information avoidance during the global health crisis. Data were collected from 321 Finnish adults using an online survey. People found to seek information from traditional sources such as mass media, print media, and online sources such as official websites and websites of newspapers and forums. Social media and personal networks were not the preferred sources. On the other hand, among different information sources, social media exposure has a significant relationship with information overload as well as information anxiety. Besides, information overload also predicted information anxiety, which further resulted in information avoidance.
A study on covid-19 data of India, Andhra Pradesh and Telangana using machine learning algorithms	Soujanya,  KLS,  Latha, et al	European Journal of Molecular and Clinical Medicine	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	This study applies multiple regression analysis which is one of the supervised machine learning algorithms to analyze and forecast the fatality rate. The study was conducted to predict the spread of Covid-19 in areas of Telangana, Andhra Pradesh, and India. The results reveal that the case fatality rate is higher in Telangana compared to Andhra Pradesh and India, and more diseased cases are observed in Andhra Pradesh.
Using RT-PCR Testing to Assess the Effectiveness of Outbreak Control Efforts in São Paulo State, the Pandemic’s Epicenter in Brazil, according to Socioeconomic Vulnerabilities	Sousa,  TatianeCM,  Moreira, et al	medRxiv	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique Surveillance	We developed an RT-PCR testing intensity effort index (RT-PCR TIEI) composed of seven indicators to assess the survelliance efforts in the São Paulo State. We used dynamic time-series cross-sectional models to analyze the association between the RT-PCR TIEI, the population living under high socioeconomic vulnerability levels, dependent on public health service (SUS), per capita income, and population density. Testing efforts declined as the pandemic advanced, and the the lowest RT-PCR TIEI values were found in the most socioeconomic vulnerable RHDs. Local public laboratory presence was a predictor of a higher score. Thus, the low testing RT-PCR efforts and local laboratory inequalities affected surveillance capability, especially for socioeconomic vulnerable populations.
Effects of COVID-19 Epidemic Lockdown on Postpartum Depressive Symptoms in a Sample of Italian Mothers	Spinola,  O,  Liotti, et al	Frontiers in Psychiatry	Mental Health | santé mentale	This study aims to explore the impact of COVID-19 on postpartum depressive symptoms in mothers with children below 1 year of age. An online questionnaire survey was therefore conducted in Italy between May and June 2020. The prevalence of postpartum depression symptomatology among mothers was 44%. Women who spent the isolation in northern Italy adopted maladaptive coping strategies significantly more than women living in areas at lower risk. The analysis highlighted a significant difference between the group that was not directly affected by the virus and women who have had a direct or indirect contact with it. Besides situational factors specific to the pandemic, the results show that there are some risk factors tied to the personal history of the mother (e.g., having had a previous abortion).
The impact of the crisis generated by COVID-19 on the population concerns. A comparative study at the level of the European Union	Stefan,  G,  Coca, et al	Transformations in Business and Economics	Economics | Économie	The purpose of this article is to highlight the impact generated by the COVID-19 pandemic on the population’s concerns about its standard of living in the countries of the European Union. Through a quantitative analysis, the authors aim to explain the effects of the COVID-19 crisis on GDP and the main concerns of the population regarding the possible decline in living standards, caused precisely by the decline in GDP. In addition, the authors highlight the vulnerabilities of the European economy to such a crisis and propose, in summary, some policies to limit its negative effects.
The National Seroprevalence of SARS−CoV−2 Antibody in the Asymptomatic Population	Stout,  Robert,  Rigatti, et al	medRxiv	Epidemiology| Épidémiologie Immunology | Immunologie	In September we tested a convenience sample of 63,106 life insurance applicants for COVID−19 and found a prevalence of 6.6%. Using 2019 US census estimates this equals more than 11.1 million (bootstrap 95% CI: 10.8 − 11.5 million) asymptomatically infected patients, which is double the number of cases reported to CDC as of September 1st.
Perceived risk, attitudes, and behavior of cigarette smokers and nicotine vapers receiving buprenorphine treatment for opioid use disorder during the COVID-19 pandemic	Streck,  JM,  Kalkhoran, et al	Drug and alcohol dependence	Public Health response| Interventions de santé publique	A telephone survey was conducted in March-July 2020 of current cigarette smokers or nicotine vapers with OUD who were stable on buprenorphine treatment at five Boston (MA) area community health centers.  222/520 patients (43 %) completed the survey, and 145 were asked questions related to COVID-19.  Nearly 80 % of participants believed that smoking and vaping increased their risk of COVID-19 infection or complications. Smokers with this belief reported an increased interest in quitting. Overall, 49 % of smokers and 42 % of vapers reported increased interest in quitting due to the pandemic; 24 % and 20 %, respectively, reported attempting to quit since the pandemic. However, 35 % of smokers and 27 % of vapers reported increasing smoking and vaping, respectively, during the pandemic.
Has W.H.O done an error with covid-19 in regardance with its January-2020 report on human to human transmission- a survey on a popular perception	Subaraman,  M,  Lakshmanan, et al	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	The questionnaire was prepared and administered to 100 people in of Tamil Nadu state. The questionnaire had  questions about COVID-19 and the January World Health Organization (WHO) report. These questions help to determine perception on COVID-19 and WHO January report and help to depict their knowledge and awareness on this topic and what is their critical perception of the role of WHO in handling the COVID pandemic.  In the present study, around 71% of the participants are aware of the COVID-19 pandemic and the controversial role played by WHO.
Where has all the influenza gone? The impact of COVID-19 on the circulation of influenza and other respiratory viruses, Australia, March to September 2020	Sullivan,  SG,  Carlson, et al	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin	Public health interventions*| Interventions de sant&amp;eacute; publique	Australia expected co-circulation of SARS-CoV-2, influenza and other seasonal respiratory viruses. However, influenza notifications were 7,029 (March-September) compared with an average 149,832 for the same period in 2015-2019, despite substantial testing. Restrictions on movement within and into Australia may have temporarily eliminated influenza. Other respiratory pathogens also showed remarkably changed activity in 2020.
Psychopathology analysis of 23 cases with COVID-19 pneumonia accompanied by abnormal brain imagine	Sun,  Fengli,  Chen, et al	Research Square prepub	Clinical data| Données cliniques	All the cases were from a hospital in China  diagnosed with COVID-19 pneumonia with abnormality of cranial CT examination were analysed. All 23 patients had mental symptoms of consciousness disturbance, cognitive impairment, anxiety and depression, sleep disorder. The more and serious mental symptoms correlated with dangerous and severe or severe type of COVID-19 pneumonia, more physical disease.
Antiretroviral treatment interruption among people living with HIV during COVID-19 outbreak in China: a nationwide cross-sectional study	Sun,  Y,  Li, et al	Journal of the International AIDS Society	Healthcare Response | Réponse des soins de santé	We aimed to explore the characteristics and factors associated with antiretroviral therapy (ART) interruption (ATI) during the COVID-19 outbreak in China.  Over one-third (35.1%, 1782/5084) reported any risk of ATI during the COVID-19 outbreak. People living with HIV with ATI were more likely to have previous interruptions in ART, travelled away from where they typically receive HIV care, stayed in an area that implemented citywide lockdowns or travel restrictions to control COVID-19, and be in permanent residence in a rural area.
Disappearance of summer influenza in the Okinawa prefecture during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic	Sunagawa,  S,  Iha, et al	Respiratory Investigation	Public health interventions*| Interventions de sant&amp;eacute; publique	After the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in January 2020, measures to avoid disease transmission have been widely promoted in Japan, such as the use of masks, handwashing, remote work, and cancellation of large events. These measures might also have reduced the spread of other infectious diseases, such as the seasonal influenza. Based on this background, we evaluated weekly influenza activity in the 2019/2020 season. After the SARS-CoV-2 pandemic, the summer influenza in the Okinawa prefecture disappeared in 2020.
A multipronged deep omics-based investigation of COVID-19 plasma samples identifies key molecular networks of disease severity progression	Suvarna,  Kruthi,  Srivastava, et al	Research Square prepub	Clinical data| Données cliniques Coronavirology| Coronavirologie Therapeutics| Thérapeutique	We employed high resolution mass spectrometry-based deep proteomics and metabolomics based investigation to study a cohort of 186 patients plasma samples to understand the COVID-19 disease severity mechanism. Of the 1200 proteins detected, 27 were differentially regulated in COVID positive group while 38 were found to be differentially expressed between non-severe and severe groups. Using our proteomics dataset and docking studies we found FDA-approved drugs Selinexor and Ponatinib having potential to be repurposed for the therapeutics intervention of COVID-19.
Without a mask: Judgments of corona virus exposure as a function of inter personal distance	Svenson,  O,  Appelbom, et al	Judgment and Decision Making	Public Health response| Interventions de santé publique	We investigated how people judge the protective effect of interpersonal distance against the Corona virus. In a comparison with model predictions, most participants underestimated the protective effect of moving further away from another person. Correspondingly, most participants were not aware of how much their exposure would increase if they moved closer to the other person.
COVID-19 in HIV-infected patients: A case series and literature review	Swaminathan,  N,  Moussa, et al	Journal of medical virology	Clinical data| Données cliniques	This case series reviews the clinical and laboratory characteristics of COVID in PLWH admitted to a community hospital. All patients had at least one comorbidity. Half the patients had an active mental health problem/cognitive impairment and 33% had an active substance use problem. Five of the six were noted to be compliant with their ART preadmission. Majority of the patients were on INSTIs. The distribution of COVID severity was one mild, three moderate, one severe, and one critical. Two patients expired due to post‐cardiac arrest syndrome and worsening hypoxic respiratory failure, respectively. Of the remaining four, two required supplemental oxygen during admission and the other two did not. One patient was discharged on home‐oxygen.
A Strategy to Treat COVID-19 Disease With Targeted Delivery of Inhalable Liposomal Hydroxychloroquine: A Preclinical Pharmacokinetic Study	Tai,  TT,  Wu, et al	Clinical and Translational Science	Therapeutics| Thérapeutique Animal model | Modèle animal	Here, we describe a preclinical study to investigate the pharmacokinetics (PKs) of a novel formulation of liposomal Hydroxychloroquine (HCQ) administered by intratracheal (IT) instillation in Sprague-Dawley rats. Results demonstrated the proof of concept that inhalable liposomal HCQ may provide clinical benefit and serve as a potential treatment for COVID-19.
A red mirage—Did the association of the 2016 presidential election results with the COVID-19 epidemic magically disappear in 2020?	Takagi,  H	Journal of medical virology	Epidemiology| Épidémiologie	The 2020 vote ratio and demographic/socioeconomic characteristics were entered into the regression as covariates for the logarithmic‐transformed COVID‐19 incidence. The univariable regression demonstrated that the vote ratio (for Biden vs. Trump) was significantly and negatively associated with the COVID‐19 incidence, which would indicate that the COVID‐19 incidence decreases as the vote for Biden increases.
Factors associated with decision making on COVID-19 vaccine acceptance among college students in South Carolina	Tam,  Cheuk Chi,  Qiao, et al	medRxiv	Public Health response| Interventions de santé publique	The current study aims to explore COVID-19 vaccine acceptance among college students in South Carolina and examine how they weigh these factors according to their levels of COVID-19 vaccine acceptance (i.e., acceptance, hesitance, refusal). About 60.6% of the college students reported they would definitely or likely take COVID-19 vaccine when available.  Duration of vaccine protection, vaccine accessibility, and authoritative advice were considered important among the acceptance group; Negative consequences of vaccination and vaccine characteristics were considered important by the refusal group.
Data-driven approach to understand the mobility patterns of the portuguese population during the covid-19 pandemic	Tamagusko,  T,  Ferreira, et al	Sustainability (Switzerland)	Epidemiology| Épidémiologie Public Health response| Interventions de santé publique	This study uses data from Google COVID-19 Community Mobility Reports to understand the Portuguese population’s mobility patterns during the COVID-19 pandemic. In this study, the Rt value was modeled for Portugal. Thus, the mobility pattern change was used to understand the impact of social distance measures on the dissemination of COVID-19. As a result, it can be stated that the initial Rt value in Portugal was very close to 3, falling to values close to 1 after 25 days. Social isolation measures were adopted quickly. Furthermore, it was observed that public transport was avoided during the pandemic.
Current status of COVID-19 among hemodialysis patients in the East Azerbaijan Province of Iran	Tayebi Khosroshahi,  H,  Mardomi, et al	Hemodial Int	Epidemiology| Épidémiologie Clinical data| Données cliniques	A total of 670 maintained hemodialysis patients from all dialysis units of the East Azerbaijan Province of Iran, including 44 COVID-19 patients were included in the present study. Possible associations between the backgrounds of patients and the incidence of COVID-19 were assessed. Chronic glomerulonephritis patients and those with blood group A demonstrated a higher incidence of COVID-19. On the other hand, patients with blood group AB(+) and those with hypertension etiology of kidney failure demonstrated a lower incidence of COVID-19. Hemodialysis patients with COVID-19 had higher counts of polymorphonuclears (PMNs) in their peripheral blood compared to other COVID-19 patients.
Risk factors for death in adult COVID-19 patients: Frailty predicts fatal outcome in older patients	Tehrani,  S,  Killander, et al	International Journal of Infectious Diseases	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study investigated demographics, comorbidities, and death rate in hospitalized patients with confirmed COVID-19.  A total of 255 randomly selected COVID-19 patients admitted to a university hospital were included and followed up for 60 days. At the 60-day follow-up, 70 patients (27%) had died. In multivariate analyses, age, chronic kidney disease, and previous stroke were associated with death. Most fatal cases (90%) occurred in patients aged 65 years or older. Among such patients, CFS level was the only predictor of death in multivariate analyses.
PMC7711176; People living with Type 1 diabetes point of view in COVID-19 times (COVIDT1 Study): disease impact, health system pitfalls and lessons for the future	Tejera,  C,  Moreno-Pérez, et al	Diabetes Res Clin Pract	Healthcare Response | Réponse des soins de santé	The aim of this cross-sectional study was to analyse the effects of confinement among people with type 1 diabetes (T1D) and their caregivers over the course of the COVID-19 crisis and to evaluate contemporary changes in medical assistance and patient preferences. Over the course of the COVID-19 pandemic, at least two-thirds of people with T1D underwent changes in the management of their condition. Almost all participants agreed with the concept of telemedicine, favouring telephone and video calls as their preferred means of communication.
Mood Responses Associated With COVID-19 Restrictions	Terry,  PC,  Parsons-Smith, et al	Frontiers in Psychology	Mental Health | santé mentale	The aim of the current study was to investigate mood responses during the period of restrictions from March to June, 2020. Mood responses of 1,062 participants (386 male, 676 female) were collected using the Brunel Mood Scale. The mean pattern of mood responses reflected an inverse iceberg profile, characterized by significantly elevated scores for tension, depression, anger, fatigue, and confusion, and below average scores for vigor. Females reported more negative mood scores than males. Participants in the ≤25 age group reported the most negative profiles. Mood differences related to education status were also evident. Finally, mood scores fluctuated over time, with profiles being most negative during April and June.
Parallel testing of 241 clinical nasopharyngeal swabs for the detection of SARS-CoV-2 virus on the Cepheid Xpert Xpress SARS-CoV-2 and the Roche cobas SARS-CoV-2 assays	Tham,  JWM,  Ng, et al	Clinical Chemistry and Laboratory Medicine	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	We assayed 241 fresh clinical nasopharyngeal (NP) swab samples in parallel on both the Xpert and the cobas assays to allow for a head-to-head comparative analysis. Following testing of 241 NP swabs, 58 tested positive and 172 tested negative with both assays, for an agreement of 95%. The present work challenged the assays’ detection limit using 58 clinical samples with low viral titers.
Awareness of various measures taken by different governments in controlling Covid-19 Pandemic-A survey	Thirukumaran,  Lakshmanan,  G, et al	European Journal of Molecular and Clinical Medicine	Public Health response| Interventions de santé publique	The main aim of this study is to determine and rank the measures adopted by each country to fight against covid 19. An online survey was conducted with a self-structured questionnaire comprising 10 questions that were distributed through the google docs. The sample size of this study was 100.  From this study population, 88% of the study population agreed that Covid 19 has to be controlled by all means. Nearly 70% of the population follows social distancing and 56% of them follow self isolation if they have symptoms and every country is working hard to contain it and minimise its impact.
PMC7709580; Impact of low serum calcium at hospital admission on SARS-CoV-2 infection outcome	Torres,  B,  Alcubilla, et al	Int J Infect Dis	Epidemiology| Épidémiologie Clinical data| Données cliniques	We performed a retrospective analysis of hospitalized patients with SARS-CoV-2 infection (n=316) and included all patients who had any serum calcium measurement in the first 72 hours since hospital admission with the objective to investigate the relation of low serum calcium with adverse outcome. A higher number of patients in the hypocalcemia group required high oxygen support during hospitalization (49% vs 32%; p = 0,01) and were admitted to the ICU (42% vs 26%; p = 0,005). No differences in mortality were observed between groups.
Incidence and outcome of SARS-CoV-2 infection on solid organ transplantation recipients: A nationwide population-based study	Trapani,  S,  Masiero, et al	Am J Transplant	Epidemiology| Épidémiologie Clinical data| Données cliniques	The cumulative incidence (CI) and the outcome of SARS‐COV‐2 infection in solid organ transplant recipients (SOTRs) in Italy was assessed. The CI of SARS‐CoV‐2 infection in SOTRs was 1.02%, higher than in COVID+ Non‐SOTRs (0.4%, p<0.05) with a greater risk in the Lombardy region (2.89%). The 60 day CI of mortality was 30.6%, twice as much that of COVID+ Non‐SOTRs (15.4%) with a 60 day gender & age adjusted odds ratio (adjusted‐OR) of 3.83 for COVID+ SOTRs [95%CI (3.03‐4.85)]. The lowest 60 day adjusted‐OR was observed in liver SOTRs [OR 0.46, 95%CI (0.25‐0.86)].
Invasive pulmonary aspergillosis associated with COVID-19 in a kidney transplant recipient	Trujillo,  H,  Fernández-Ruiz, et al	Transplant Infectious Disease	Clinical data| Données cliniques	We describe a case of a kidney transplant recipient with severe COVID‐19 that was subsequently diagnosed with probable invasive pulmonary aspergillosis (IPA) on the basis of the repeated isolation of Aspergillus fumigatus in sputum cultures, repeatedly increased serum (1 → 3)‐β‐d‐glucan levels, and enlarging cavitary nodules in the CT scan. The evolution was favorable after initiation of isavuconazole and nebulized liposomal amphotericin B combination therapy and the withdrawal of immunosuppression.
A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: A bedside-to-bench study	Tsai,  KC,  Huang, et al	Biomedicine and Pharmacotherapy	Clinical data| Données cliniques Therapeutics| Thérapeutique	Among 33 patients with confirmed COVID-19 admitted in two medical centers, those (n = 12) who were older, sicker, with more co-existing conditions and showing no improvement after 21 days of hospitalization were given NRICM101, a novel traditional Chinese medicine formula. They achieved 3 consecutive negative results within a median of 9 days and reported no adverse events. Pharmacological assays demonstrated the effects of the formula in inhibiting the spike protein/ACE2 interaction, 3CL protease activity, viral plaque formation, and production of cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α. This bedside-to-bench study suggests that NRICM101 may disrupt disease progression through its antiviral and anti-inflammatory properties, offering promise as a multi-target agent for the prevention and treatment of COVID-19.
Olfactory bulb and mucosa abnormalities in persistent COVID-19-induced anosmia: a magnetic resonance imaging study	Tsivgoulis,  G,  Fragkou, et al	European Journal of Neurology	Long-Term Sequelae | séquelles à long terme	Adult, non‐hospitalized patients who recovered from laboratory‐confirmed COVID‐19 infection and self‐reported persistent olfactory dysfunction for ≥40 days after symptom onset (n=8) were evaluated by MRI at a referral center in Athens, Greece (‘Attikon’ University Hospital). The bilateral olfactory bulb (OB) height in cases was significantly lower than in controls (mean ± SD 1.16 ± 0.33 vs. 1.58 ± 0.36; P = 0.004), indicative of mild to moderate OB atrophy in 88% of the patients. Moreover, MRI demonstrated olfactory mucosa (OM) thickening in four cases.
Self-Isolation Due to COVID-19 Is Linked to Small One-Year Changes in Depression, Sleepiness, and Insomnia: Results from a Clinic for Sleep Disorders in Shiga Prefecture, Japan	Ubara,  A,  Sumi, et al	Int J Environ Res Public Health	Mental Health | santé mentale	We aimed to analyze (a) the changes in depression, sleepiness, insomnia, and sleep habits in relation to the degree of self-isolation and (b) the effects of changes in sleep habits and social interactions on depression, insomnia, and sleepiness during the coronavirus disease 2019 (COVID-19) pandemic in 164 patients. We found significant differences in sleep duration between the no/little self-isolation group and the strong self-isolation group (p = 0.047). Therefore, self-isolation due to COVID-19 had relatively small one-year effects on depression, sleepiness, and insomnia in a clinical population.
Detection of abnormalities in covid-19 infected human respiratory system using accelerometer with the aid of machine learning	Uday Kiran,  K,  Shakeela, et al	International Journal of Pharmaceutical Research	Clinical data| Données cliniques	This paper focused on the respiratory abnormalities in the COVID-19 patient. The proposed method uses a 3-Axis Accelerometer ADXL335 to obtain the Respiratory rate data from a normal human being and a COVID-19 patient using a NodeMcu Microcontroller. The data is then applied to a Machine learning algorithm to detect the abnormalities in the COVID-19 patient. The data from the cloud further analyzed by a machine algorithm called One-Class SVM to detect the anomalies in the respiratory data.
Evolution of intersectional perceived discrimination and internalized stigma during COVID-19 lockdown among the general population in Spain	Ugidos,  C,  López-Gómez, et al	Int J Soc Psychiatry	Mental Health | santé mentale	The aim of the present study is to analyze longitudinally the evolution of intersectional perceived discrimination and internalized stigma among the general population of Spain, at three points in time throughout the COVID-19 confinement. Results show an increase in both variables from the first to the second evaluation, and a slight decrease from the second to the third evaluation. Moreover, these changes are explained by depression, anxiety and family support.
Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 in vitro	Unal,  Mehmet Altay,  Bitirim, et al	bioRxiv	Therapeutics| Thérapeutique	(Preprint) We aimed to show the anti-SARS-CoV-2 activity of ribavirin via in vitro, in silico and molecular techniques. Ribavirin showed antiviral activity in Vero E6 cells following SARS-CoV-2 infection.  Ribavirin was shown to decrease TMPRSS2 expression both at mRNA and protein level 48 hours after treatment. The suppressive effect of Ribavirin in ACE2 protein expression was shown to be dependent on cell types. Finally, proteolytic activity assays showed that Ribavirin also showed an inhibitory effect on TMPRSS2 enzyme.
Involvement of the mediastinal subpleural pulmonary parenchyma on chest ct in covid-19 patients: A case series	Urciuoli,  L,  Guerriero, et al	Journal of Radiology Case Reports	Clinical data| Données cliniques	Here we report eight confirmed COVID-19 cases who underwent clinical evaluation, laboratory testing, and unenhanced chest CT. In all patients, chest CT showed the presence of ground-glass opacities in the mediastinal subpleural parenchyma. While these cases also showed the typical CT features of COVID-19, involvement of the mediastinal subpleural parenchyma should not lower the index of suspicion for COVID-19.
Use of Face Masks Among Patients With Psychiatric Illnesses During the COVID-19 Pandemic: A Hospital-Based Cross-Sectional Study	Uvais,  NA	The primary care companion for CNS disorders	Public Health response| Interventions de santé publique	The objective of this hospital-based cross-sectional study was to examine the practice of using face masks among psychiatric patients in India. In conclusion, the findings of this study suggest that although the majority of the study participants used face masks, mostly cloth masks, while visiting the hospital, many used face masks inappropriately. These results might be of value in the creation of education campaigns on the proper use of face masks to reduce the spread of COVID-19 infection among the psychiatric patient population.
Impact of Covid-19 on Stroke Code Activations, Process Metrics, and Diagnostic Error	Velez,  FGS,  Alvarado-Dyer, et al	Neurohospitalist	Healthcare Response | Réponse des soins de santé	In a comprehensive stroke center, we analyzed the stroke code activations (SCA) (n=212), assessed the impact of Covid-19, and the measures taken by the local government to lessen the spread of the disease. An increase in door-to-CT time (p = 0.001) and an increase in the rate of diagnostic error in patients admitted from the Emergency Department (ED) (p = 0.016) were seen. We observed a rapid decline and slow recovery in ED SCA with a shift toward increased true positive cases following the Covid-19 pandemic. Also, delays in obtaining CT and diagnostic error was increased, however, no difference in early clinical outcomes were seen between groups.
Mapping each pre-existing conditions association to short-term and long-term COVID-19 complications	Venkatakrishnan,  AJ,  Pawlowski, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	(Preprint) We leverage 1.1 million clinical notes from 1,903 hospitalized COVID-19 patients and deep neural network models to characterize associations between 21 pre-existing conditions and the development of 20 complications (e.g. respiratory, cardiovascular, renal, and hematologic) of COVID-19 infection throughout the course of infection (i.e. 0-30 days, 31-60 days, and 61-90 days).  Pleural effusion was the most frequent complication of early COVID-19 infection (23% of 383 complications) followed by cardiac arrhythmia (12% of 383 complications). Notably, hypertension was the most significant risk factor associated with 10 different complications including acute respiratory distress syndrome, cardiac arrhythmia and anemia. The associations between pre-COVID conditions and COVID-associated complications presented here may form the basis for the development of risk assessment scores to guide clinical care pathways.
Nasopharyngeal microbial communities of patients infected with SARS-COV-2 that developed COVID-19	Ventero,  Maria Paz,  Cuadrat, et al	bioRxiv	Clinical data| Données cliniques	In this study, we investigated the nasopharyngeal microbiome composition of patients who developed different severity levels of COVID-19. Our preliminary study shows that the nasopharyngeal microbiome of COVID-19 patients showed differences in the composition of specific OTUs and complexity of co-abundance networks. These microbes with differential abundances among groups could serve as biomarkers for COVID-19 severity.
McQ - An open-source multiplexed SARS-CoV-2 quantification platform	Vonesch,  SibylleC,  Bredikhin, et al	medRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Here we describe Multiplexed SARS-CoV-2 Quantification platform (McQ), an inexpensive scalable framework for SARS-CoV-2 quantification in saliva samples. We demonstrate the ability of McQ to robustly quantify various levels of viral RNA in 838 clinical samples and accurately diagnose positive and negative control samples in a testing workflow entailing self-sampling and automated RNA extraction from saliva.
Effects of Tocilizumab in COVID-19 patients: a cohort study	Vu,  Christine,  Deronde, et al	Research Square prepub	Clinical data| Données cliniques Therapeutics| Thérapeutique	We evaluated the effects of early administration of tocilizumab for COVID-19 in this  retrospective, observational study conducted on hospitalized adults. By day 30, 36 patients (60.0%) demonstrated clinical improvement, 9 (15.0%) died, 33 (55.0%) were discharged alive, and 18 (30.0%) remained hospitalized. Majority of patients demonstrated clinical improvement and were successfully discharged from the hospital alive after receiving tocilizumab. We observed a rebound effect with CRP, which may suggest the need for higher or subsequent doses to adequately manage cytokine storm.
Psychological defence mechanisms during the COVID-19 pandemic: A case series	Walker,  G,  McCabe, et al	European Journal of Psychiatry	Mental Health | santé mentale	This paper aims to describe a range of psychological defence mechanisms encountered within colleagues in relation to the COVID-19 pandemic. The author has encountered varying psychological defence mechanisms, both within himself and in other members of the multidisciplinary team. These have been illustrated in the attached clinical vignettes, relating to the specific psychological coping mechanisms of; denial, hypochondriasis, altruism, sublimation and humour.
Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes	Wang,  A,  Chiou, et al	eLife	Clinical data| Données cliniques	Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes of 46,500 nuclei in non-diseased lungs from donors of ~30 weeks gestation,~3 years and ~30 years. We identified distal cCREs with age-increased activity linked to SARS-CoV-2 host entry gene TMPRSS2 in alveolar type 2 cells, which had immune regulatory signatures and harbored variants associated with respiratory traits. Our findings provide insight into regulatory logic underlying genes implicated in COVID-19 in individual lung cell types across age.
Perforated Appendicitis: An Unintended Consequence During the Coronavirus-19 Pandemic	Wang,  AW,  Prieto, et al	Mil Med	Healthcare Response | Réponse des soins de santé	We sought to describe the effect of the global pandemic on the presentation and outcomes for the most common urgent general surgery disease process, acute appendicitis. At our overseas military hospital with minimal disease burden, we observed a delay in presentation for acute appendicitis with a higher incidence of perforation. Patients should be empowered to continue to seek care for urgent and emergent medical and surgical conditions so that they are not harmed by fear of COVID-19 rather than by COVID-19 itself.
Predictive modeling of morbidity and mortality in COVID-19 hospitalized patients and its clinical implications	Wang,  JoshuaM,  Liu, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objective of this retrospective study of COVID-19 positive patients treated at NYU Langone Health (NYULH) was to identify clinical markers predictive of disease severity to assist in clinical decision triage and provide additional biological insights into disease progression. XGBoost model trained on clinical data from the final 24 hours excelled at predicting mortality (AUC=0.92, specificity=86% and sensitivity=85%). Performance of this model to predict the deceased outcome extended 5 days prior with AUC=0.81, specificity=70%, sensitivity=75%. When only using clinical data from the first 24 hours, AUCs of 0.79, 0.80, and 0.77 were obtained for deceased, ventilated, or ICU admitted, respectively.
PMC7714896; CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells	Wang,  K,  Chen, et al	Signal Transduct Target Ther	Coronavirology| Coronavirologie	Here, we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein. The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody, Meplazumab, inhibits SARS-CoV-2 amplification. Viral loads are detectable in the lungs of human CD147 (hCD147) mice infected with SARS-CoV-2, but not in those of virus-infected wild type mice. Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dose-dependent manner, which is specifically inhibited by Meplazumab.
Impacts of the coronavirus disease 2019 epidemic on the psychological health of women on fertility treatment	Wang,  M,  Zhao, et al	Journal of Xi'an Jiaotong University (Medical Sciences)	Mental Health | santé mentale	To investigate the psychological health and influencing factors of women on assisted reproduction treatment during the outbreak of the coronavirus disease 2019 (COVID-19). The psychological status of women on fertility treatment during the epidemic of the COVID-19 is mainly manifested as fear. The fear of these urban women with high education level and good family economy is the most serious. Promotion of psychological health during the epidemic should be strengthened to reduce the psychological harm of the epidemic.
Could the ambient higher temperature decrease the transmissibility of COVID-19 in China?	Wang,  Q,  Zhao, et al	Environ Res	Epidemiology| Épidémiologie Transmission	We explore the association between ambient temperature and transmissibility of COVID-19 in different regions across China. There were 12745 COVID-19 cases collected in the study areas. We report the effect of temperature on Rt is likely to be negative but not of statistical significance, which holds for most of included regions except for those in North China. We found little statistical evidence for that the higher temperature may reduce the transmissibility of COVID-19.
Quantifying the time-lag effects of human mobility on the COVID-19 transmission: A multi-city study in China	Wang,  X,  Pei, et al	IEEE Access	Transmission Public health interventions*| Interventions de sant&amp;eacute; publique	This study aims to quantify this time-lag effect between the reduction in human mobility and the decline in COVID-19 transmission and reveal its influencing socio-demographic and environmental factors. The results show that mobility is strongly correlated with COVID-19 transmission in most cities with lags of 10 days (interquartile range 8 – 11 days) and correlation coefficients of 0.68±0.12.  These findings suggest that cities with compact urban structure should strictly adhere to human mobility restrictions, while economically prosperous cities should also strengthen other non-pharmaceutical interventions to control the spread of the virus.
Clinical effect of the treatment of novel coronavirus pneumonia by internal administration of traditional Chinese medicine plus fumigation and absorption combined with super dose of vitamin C in treating COVID-19	Wang,  Y,  Yang, et al	Journal of Xi'an Jiaotong University (Medical Sciences)	Therapeutics| Thérapeutique	To study the characteristics and regularity of the improvement of early clinical symptoms of coronavirus disease 2019 (COVID-19) treated with Chinese medicine plus fumigation and absorption combined with super dose of vitamin C.  The combination of traditional Chinese medicine and fumigation and absorption combined with super dose of vitamin C has a definite effect on the improvement of fatigue, cough, dry throat and shortness of breath in patients with COVID-19.
Transition from room temperature to cold-stored platelets for the preservation of blood inventories during the COVID-19 pandemic	Warner,  MA,  Kurian, et al	Transfusion	Healthcare Response | Réponse des soins de santé	The COVID‐19 pandemic has placed great strain on blood resources. We describe the administrative and technical processes involved in transitioning room temperature platelet (PLT) to cold storage in April 2020 in an effort to extend PLT shelf life and minimize waste. Cold‐stored PLT utilization was associated with adequate hemostasis and no overt signal for patient harm. Conversion from room temperature to cold‐stored PLTs may be one method of reducing waste in times of scarce blood inventories.
Who comes when the world goes Code Blue? A novel method of exploring job advertisements for COVID-19 in health care	Watts,  RD,  Bowles, et al	Nursing Open	Healthcare Response | Réponse des soins de santé	We collected advertisements for healthcare jobs which were caused by and in response to COVID‐19 between 4 March–17 April 2020 for the United States, Canada, United Kingdom, Australia and New Zealand. Nurses were the most advertised position in every country. Frontline workers were substantially more demanded than coordination or decision‐support roles. The initial phases of the response emphasise the importance of frontline workers, especially nurses.
Longer time spent at home during COVID-19 pandemic is associated with binge drinking among US adults	Weerakoon,  SM,  Jetelina, et al	Am J Drug Alcohol Abuse	Public Health response| Interventions de santé publique	This analysis aims to identify COVID-19-related stressors associated with changes in alcohol consumption and binge drinking since the outbreak of the coronavirus.  Data were collected on sociodemographics, alcohol consumption, and COVID-19-related stressors (household composition, job status, essential worker, stay-at-home duration, and depression) using a web-based, self-report survey to US adults from mid-March to mid-April 2020. For every 1-week increase in time spent at home during the pandemic, there was 1.21 (95% CI: 1.08–1.35) greater odds of binge drinking. Additionally, binge drinkers with a previous diagnosis of depression and current depression symptoms had greater odds of increased alcohol consumption compared to those reporting no depression (AOR = 1.80, 95% CI: 1.15–2.81).
PMC7708826; Comparative evaluation of four rapid SARS-CoV-2 antigen detection tests using universal transport medium	Weitzel,  T,  Legarraga, et al	Travel Med Infect Dis	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Here we present a head-to-head comparison of four novel antigen-based rapid diagnostic tests (RDTs) for the detection of SARS-CoV-2 from respiratory specimens. The study included a total of 111 samples from symptomatic patients. The evaluation of the Liming Bio kit was stopped after 19 samples, due to its poor results. The other three assays had sensitivities ranging from 16.7% (Savant) to 85% (Bioeasy) and a specificity of 100%. Sensitivities were significantly higher in specimens with high viral loads (Ct values ≤25) for RapiGen (84.9%) and Bioeasy (100%). The results emphasize that rapid antigen detection has the potential to serve as an alternative diagnostic method, especially as a screening tool for patients with high viral loads during early and infective stages of infection.
The effect of social media exposure on depression and anxiety disorders in facing Covid-19 pandemic	Widiyanto,  A,  Fajriah, et al	European Journal of Molecular and Clinical Medicine	Mental Health | santé mentale	This study aims to predict the effect of social media exposure on depression and anxiety disorders in health students in the face of the Covid-19 pandemic.  Results from the study found that there was a significant effect of social media exposure on depression (OR=1.64; CI 95%=1.05 hingga 2.57; p=0.031) and anxiety disorders (OR=1.64; CI 95%=1.18 to 3.40; p=0.008) in dealing with the Covid-19 pandemic.
Caught Red Handed	Wiener-Well,  Y,  Levin, et al	Arthritis Care Res (Hoboken)	Clinical data| Données cliniques	A 54 year-old previously healthy female patient presented with headache, nausea and vomiting, diarrhea, diffuse arthralgia and an erythematous skin rash over her face, the distal part of her hands and both calves with high fever five days. We suggest that the patient did not have an acute COVID-19 infection when she was admitted as repeat PCR testing was negative. SARS-CoV-2 anti-IgG antibodies were identified, so it is possible that the rash, peri-myocarditis and shock on presentation were actually "post infectious autoimmune features" of SARS-CoV-2 infection. This parallels recent reports of Kawasaki-like illness or MIS-C/MIS-A among children and adults with COVID-19.
Comparisons of early and late presentation to hospital in COVID-19 patients	Williams,  S,  Sheard, et al	Respirology	Epidemiology| Épidémiologie Clinical data| Données cliniques	We aimed to identify the differences between ‘early presenters’ (patients presenting to hospital <7 days from symptom onset) and ‘late presenters’ (≥7 days from symptom onset) to explore the relationship between the timing of symptom onset at presentation to hospital and disease outcome (n=574 SARS‐CoV‐2‐positive patients). Although early presenters were less likely to have infiltrates on their CXR (P < 0.001), the presence of infiltrates in this group revealed increased risk of adverse outcome (odds ratio (OR): 1.90, 95% CI: 1.11, 3.25). The presence or lack of infiltrates in late presenters was not predictive of outcome (OR: 0.58, 95% CI: 0.30, 1.16).
Mass Screening for SARS-CoV-2 Uncovers Significant Transmission Risk from Asymptomatic Carriers	Wilmes,  Paul,  Zimmer, et al	SSRN- Lancet prepublication	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	To accompany the lifting of COVID-19 lockdown measures, Luxembourg implemented a mass testing programme including the performance of high-throughput rRT-PCR using a validated pooling strategy.  Sensitivity and specificity of the test protocol were 100%. The programme identified 850 index cases with an additional 249 cases resulting from contact tracing, corresponding to 26% of positive cases of the epidemic wave. Based on simulations using a tailored agent-based SEIR model, the total number of expected cases would have been 39·1% higher without the mass screening programme.
Screening for SARS-CoV-2 infection in asymptomatic individuals using the Panbio COVID-19 Antigen Rapid Test (Abbott) compared to RT-qPCR	Winkel,  BeatriceMF,  Schram, et al	medRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Test performance of the Panbio™ COVID-19 Ag Rapid Test (Abbott) was compared to RT-qPCR in a longitudinal cohort study of asymptomatic football players and staff members of professional football clubs. 2425 tests were performed in 824 individuals, of which 52 (6.3%) were SARS-CoV-2 positive based on RT-qPCR. Sensitivity of Panbio™ ranged from 61.76% (95% CI 49.2-73.3) to 69.12% (95% CI: 56.7-79.8) and specificity from 99.53% (95% CI: 99.2-99.8) to 100% (95% CI: 99.8-100). Sensitivity of Panbio™ to detect subjects with pre-symptomatic/early infection (n= 42) ranged from 81.82% (95% CI: 67.3-91.8) to 90.91% (95% CI: 78.3-97.5) with specificity always above 99%.
Association of individual health literacy with preventive behaviours and family well-being during COVID-19 pandemic: Mediating role of family information sharing	Wong,  JYH,  Wai, et al	International Journal of Environmental Research and Public Health	Public Health response| Interventions de santé publique	We tested a model of individual health literacy information sharing with family members, personal preventive behaviours and family well-being during the Coronavirus Disease 2019 (COVID-19) pandemic in Hong Kong.  COVID-19 information sharing with family members partially mediated the association between individual health literacy and personal preventive behaviours.
Infection control challenges in setting up community isolation and treatment facilities for patients with coronavirus disease 2019 (COVID-19): implementation of directly-observed environmental disinfection	Wong,  SC,  Leung, et al	Infect Control Hosp Epidemiol	Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé	Highlight the practice of directly-observed environmental disinfection (DOED) in the community isolation facility (CIF) and community treatment facility (CTF) in Hong Kong. Of 291 healthcare workers (HCWs)and 54 cleaning staff, who managed 243 and 674 patients in CIF and CTF, respectively, from July 24 to August 29, 2020, none of them acquired COVID-19. All 24 air samples and 520 environmental samples collected in the patient area of CTF were negative for SARS-CoV-2. Patients' compliance of wearing mask was 100%.
Outcomes of patients with hematologic malignancies and COVID-19: a report from the ASH Research Collaborative Data Hub	Wood,  WA,  Neuberg, et al	Blood Adv	Clinical data| Données cliniques	Analyzed features and outcomes of COVID-19 infection in patients with underlying blood disorders, such as hematologic malignancies. At the time of this report, data from 250 patients with blood cancers from 74 sites around the world had been entered into the registry. The most commonly represented malignancies were acute leukemia (33%), non-Hodgkin lymphoma (27%), and myeloma or amyloidosis (16%). Patients presented with a myriad of symptoms, most frequently fever (73%), cough (67%), dyspnea (50%), and fatigue (40%). Use of COVID-19-directed therapies, such as hydroxychloroquine (n = 76) or azithromycin (n = 59), was common. Overall mortality was 28%. Patients with a physician-estimated prognosis from the underlying hematologic malignancy of <12 months at the time of COVID-19 diagnosis and those with relapsed/refractory disease experienced a higher proportion of moderate/severe COVID-19 disease and death.
A Digital Program (Hope) for People Living With Cancer During the COVID-19 Pandemic: Protocol for a Feasibility Randomized Controlled Trial	Wright,  H,  Martin, et al	JMIR Res Protoc	RCT	BACKGROUND: During the COVID-19 lockdown period in the United Kingdom that began on March 23, 2020, more than a quarter of a million people with cancer reported worsening mental health. Help to Overcome Problems Effectively (Hope) is a self-management program for people with cancer, designed to provide support for distress, unmet needs, and poor psychological health. In light of social distancing during the COVID-19 pandemic, digital delivery of the Hope Programme has become ever more vital for people with cancer. Previous pre-post studies of the digital Hope Programme have found reduced anxiety and depression and improved well-being for people with cancer. However, evaluation of this evidence has been limited by the lack of a control group in these previous studies. OBJECTIVE: We now present a protocol for a feasibility randomized controlled trial of the digital Hope Programme for people with cancer during the COVID-19 pandemic. Primary outcomes will be recruitment, dropout, and adherence rates, and estimations of sample and effect size. To detect signals of efficacy, secondary outcomes will be participant mental health and well-being. METHODS: Participants will be recruited by Macmillan Cancer Support (MCS) through their social media networks. The study will employ a feasibility wait-list randomized controlled trial (RCT) design, with people with cancer being randomized to join the digital Hope Programme immediately (intervention group IG]) or join a 6-week waiting list (wait-list control group WLCG]) with a 1:1 allocation ratio. Participants will complete digital measures of depression, anxiety, mental well-being, and confidence in managing their own health. Online questionnaires will be administered preprogram and 6 weeks postprogram. RESULTS: All people who had requested access to the Hope Programme from MCS (N=61) will be invited to participate in the trial. Baseline data collection commenced in April 2020, and the Hope Programme began for the IG in May 2020 and for the WLCG in June 2020. Postprogram data collection was completed by the end of August 2020. CONCLUSIONS: This feasibility study will provide data to inform the design of a future definitive trial. Wider-scale provision of the digital Hope Programme has potential to improve the lives of thousands of people with cancer and reduce the burden on health care providers during these unprecedented times. TRIAL REGISTRATION: ISRCTN Registry ISRCTN79623250; http://www.isrctn.com/ISRCTN79623250. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/24264.
Health Care Providers' Perceptions of Quality, Acceptance, and Satisfaction With Telebehavioral Health Services During the COVID-19 Pandemic: Survey-Based Study	Wright,  J,  Dewan, et al	JMIR Ment Health	Healthcare Response | Réponse des soins de santé	Determined the initial perceptions and experiences of interprofessional behavioral health providers about shifting from traditional face-to-face care to virtual technologies (telephonic and televideo) during the COVID-19 pandemic. 170 respondents completed the survey in entirety, among which 78.8% of the respondents were female and primarily aged 36-55 years (52.4%). A majority of the respondents were outpatient-based providers (93.5%), including psychiatrists, therapists, counselors, and advanced practice nurses. Most of them (84.7%) had used televideo for less than 1 year; they felt comfortable and satisfied with either telephonic or televideo mode and that they were able to meet the patients' needs.
Main directions of credit policy during the COVID-19 pandemy	Xamid,  T,  Mansur, et al	European Journal of Molecular and Clinical Medicine	Economics | Économie	The study provides a comprehensive analysis of the credit policy pursued by the government during the Covid-19 pandemic and its results in order to support the population and businesses, to prevent large debts. The study reccomend the following: The interest rate and terms of loans not only affect the banking sector, but also directly affect the living standards and quality of life of the population. For this reason, it would be expedient to provide loans with simplified terms and conditions of repayment to support entrepreneurship in the country. According to 2020 data, the interest rates of commercial banks in the country will be 24%. Under this decree, if a preferential interest rate of 16% was applied, the financial interest of individuals after October 1, 2020 would be avoided. © 2020 Ubiquity Press. All rights reserved.
A Nomogram to Early Predict Isolation Length for Non-severe COVID-19 Patients Based on Laboratory Investigation: A Multicenter Retrospective Study in Zhejiang Province, China	Xia,  Y,  Zhang, et al	Clin Chim Acta	Clinical data| Données cliniques	Develop a model to predict isolation length for non-severe patients. Among 188 non-severe patients, 96 patients were enrolled as training cohort to identify factors associated with isolation length via Cox regression model and develop a nomogram. Other 92 patients formed as validation cohort to validate nomogram. Increasing absolute eosinophil count (AEC) after admission was correlated with shorter isolation length (P=0.02). Baseline activated partial thromboplastin time (APTT) > 30s was correlated with longer isolation length (P=0.03). A nomogram to predict isolation probability at 11-, 16- and 21-day was developed and validated. The C-indices of training and validation cohort were 0.604 and 0.682 respectively. Both cohorts showed a good discriminative ability (AUC, 11-day: 0.646 vs 0.730; 16-day: 0.663 vs 0.750; 21-day: 0.711 vs 0.783; respectively) and calibration power.
Racial and Ethnic Disparities in COVID-19 Infection and Mortality in the United States: A state-wise update	Xian,  Zhaoying,  Saxena, et al	medRxiv	Epidemiology| Épidémiologie	Evaluated COVID-19 infection and mortality in ethnic and racial sub-groups across all states in the United States. The Hispanic population had a median of 158% higher COVID-19 infection relative to their % population proportion. This was followed by African American (AA), with 50% higher COVID-19 infection relative to their % population proportion. The AA population had the most disproportionate mortality with a median of 46% higher mortality than % population proportion. Disproportionate impact of COVID-19 was also seen in American Indian or Alaska Native, (AI/AN) and Asian population with 100% excess infections than % population proportion seen in 35 states for Hispanic, 14 states for AA, 9 states for AI/AN, and 7 states for Asian populations. There was no disproportionate impact in the white population in any state.
Multi-Level Attention Graph Neural Network for Clinically Interpretable Pathway-Level Biomarkers Discovery	Xing,  Xiaohan,  Yang, et al	bioRxiv	Clinical data| Données cliniques	Propose a novel multi-level attention graph neural network (MLA-GNN), which applies weighted correlation network analysis (WGCNA) to format the omic data of each patient into graph-structured data, and then constructs multi-level graph features, and fuses them through a well-designed multi-level graph feature fully fusion (MGFFF) module to conduct multi-task prediction. Moreover, a novel full-gradient graph saliency mechanism is developed to make the MLA-GNN interpretable. MLA-GNN achieves state-of-the-art performance on transcriptomic data from TCGA-LGG/TCGA-GBM and proteomic data from COVID-19/non-COVID-19 patient sera.
PMC7716113; Characteristics of SARS-CoV-2-specific cytotoxic T cells revealed by single-cell immune profiling of longitudinal COVID-19 blood samples	Xiong,  Q,  Peng, et al	Signal Transduct Target Ther	Clinical data| Données cliniques Immunology | Immunologie	Report on the longitudinal T cell response during and after SARS-CoV-2 infection. Sequenced the circulating T cells of five moderate or severe COVID-19 patients at different stages of infection and of two healthy donors. Integrated T cell clonality analysis indicated significant clonal expansion in response to SARS-CoV-2 infection, whereas no dominant T cell clones were detected in healthy donors. The majority of the clonal T cells were localized in the effector T cell area. In contrast, only minimal B cell clonal expansion was observed. The clones identified during the active phase of infection (1 week post symptom onset) showed decreased clonality rate during the course of post infection but persisted till 16 and 17 weeks post symptom onset. In addition, the dominant clone in each patient remained so even after 16 and 17 weeks. Clonal T cells showed significantly higher expression of FGFBP2 and GZMH, which features the active anti-virus cytotoxic T cells. Further comparison of the transcriptomes of clonal CD8+ T cells at the different timepoints showed that CXCR4, DUSP2, ZFP36 and NFKBIA were downregulated and upregulated in the clonal CD8+ T cells at timepoints 1 and 3, respectively.
Physical mobility under stay-at-home orders: A comparative analysis of movement restrictions between the U.S. and Europe	Xu,  D	Economics and Human Biology	Public Health response| Interventions de santé publique	During the COVID-19 pandemic, both the U.S. and Europe have issued movement restrictions with the exception of visits to essential services, including groceries and pharmacies. Using Google's data on community mobility, I employ an event-study design to compare the effects of movement restrictions on physical mobility in the U.S. and Europe. I find that compared to Europe, the U.S. has higher levels of mobility related to visits to groceries and pharmacies and lower levels of the residential presence relative to baseline values, and the differences are not only statistically significant but also of large magnitudes. Such differences in post-restriction mobility are still significant between Europe and the U.S.’ early epicenters of COVID-19. The main results of this paper are robust to changes in samples and specifications. These findings suggest that movement restrictions appear to be less effective in the U.S., which have useful implications for health policy evaluation, pandemic forecasting, and economic recovery. © 2020 Elsevier B.V.
Knowledge, attitudes, and practices towards COVID-19 among primary school students in Hubei Province, China	Xue,  Q,  Xie, et al	Children and Youth Services Review	Public Health response| Interventions de santé publique	Investigated the knowledge, attitudes, and practices (KAP) towards coronavirus disease 2019 (COVID-19) among school-aged children in the Hubei province when children were being confined to their homes. The awareness rates about COVID-19 were 70.1%–99.5% for all 1650 valid questionnaires. 37.2% of the participants quite worried about being infected with COVID-19. Approximately 96% of them washed hands in certain situations, while 85.6% of them washed hands after coughing or sneezing. Compared to the students without depressive symptoms, those who had depressive symptoms scored lower of total KAP, knowledge, attitudes, and practice.
Machine learning analysis highlights the down-trending of the proportion of COVID-19 patients with a distinct laboratory result profile	Yang,  HeS,  Hou, et al	medRxiv	Clinical data| Données cliniques	Report the down-trending of the proportion of SARS-CoV-2 patients with the distinct COVID19 high-risk laboratory test result profile (COVID19-HRP). A COVID19-HRP, consisting of 21 routine blood tests, was identified to characterize the SARS-CoV-2 patients. Approximately half of the SARS-CoV-2 positive patients had the distinct COVID19-HRP that separated them from SARS-CoV-2 negative patients. SARS-CoV-2 patients with the COVID19-HRP had higher SARS-CoV-2 viral loads, determined by cycle-threshold values from the RT-PCR, and poorer clinical outcome compared to other positive patients without COVID19-HRP. Furthermore, the percentage of SARS-CoV-2 patients with the COVID19-HRP has significantly decreased from March/April to May/June. Notably, viral load in the SARS-CoV-2 patients declined and their laboratory profile became less distinguishable from SARS-CoV-2 negative patients in the later phase.
Clinical and Epidemiologic Evaluation of Inconclusive COVID-19 PCR Results Using a Quantitative Algorithm	Yang,  S,  Stanzione, et al	Am J Clin Pathol	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Develop a quantitative algorithm to assess and interpret inconclusive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) result. We determined 5 (28%) of 18 (CDC assay) and 20 (39%) of 51 (TaqPath assay) cases to be false positive. Lowering the cycle threshold cutoff from 40 to 37 in the TaqPath assay resulted in a dramatic reduction of the false-positive rate to 14%. We also showed testing of asymptomatic individuals is associated with a significantly higher probability of having a false-positive result.
Perceived psychological stress and associated factors in the early stages of the coronavirus disease 2019 (COVID-19) epidemic: Evidence from the general Chinese population	Yang,  X,  Xiong, et al	PLoS One	Mental Health | santé mentale	Explored the perceived psychological stress and associated factors in the early stage of COVID-19 epidemic. A total of 1638 participants were included, of whom 44.3% showed moderate psychological stress. Individuals who were younger, female, unmarried, spent more time on the disease, felt more concern about it, reported lower social support (Subjective Social support; Objective social support; Utilization social support), or showed a negative coping style were more likely to suffer higher psychological stress in the early stages of the COVID-19 epidemic.
Some at Risk for COVID-19 Are Reluctant to Take Precautions, but Others Are Not: A Case From Rural in Southern Iran	Yazdanpanah,  M,  Abadi, et al	Frontiers in Public Health	Public Health response| Interventions de santé publique	Investigated the drivers that contribute to the intention to take health protective measures among 305 rural youth from the Dashtestan Region, Bushehr Province, and southern Iran. Protection motivation theory (PMT) served as the theoretical framework for the study. It was able to forecast variation in intentions and behaviors with accuracies of 39 and 64%, respectively. Furthermore, the variables of response efficiency, perceived severity, and self-efficacy had a positive and significant effect on protective intentions. Additionally, perceived severity, self-efficacy, and intention produced a positive and significant impression on behaviors, with most of the behavioral variance being accounted for by intention, as was hypothesized. In conclusion, it is suggested that health development including training measures that take account of both the concrete issues of health resources and technologies and of more abstract ones, such as mindset readiness, are important for engagement in positive health care behaviors.
High dose ascorbic acid treatment in COVID-19 patients raised some problems in clinical chemistry testing	Yesildal,  F,  Isman, et al	Turkish Journal of Biochemistry	Therapeutics| Thérapeutique	Investigated the interference of ascorbic acid (AA) at high concentrations on commonly used chemistry assays as AA is being used to treat severe COVID19 patients.. Creatinine, sodium and glucose (POCT) tests were found to be positively interfered by increasing AA concentrations; while direct bilirubin, lipase, UIBC, triglyceride, total cholesterol, HDL/LDL cholesterol tests were negatively interfered. Absolute interference (%) increased as the AA concentration increased.
Built environment and the metropolitan pandemic: Analysis of the COVID-19 spread in Hong Kong	Yip,  TL,  Huang, et al	Building and Environment	Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions de sant&amp;eacute; publique	Investigate the missing link between the built environment and the spread of the COVID-19. The data is divided into two phases before (Phase 1) and during the social distancing measure was relaxed (Phase 2). Through survival analysis, ordinary least squares analysis, and count data analysis, we find that (1) In Phase 1, clinics and restaurants are more likely to influence the prevalence of COVID-19. In Phase 2, public transportation (i.e. MTR), public market, and the clinics influence the prevalence of COVID-19. (2) In Phase 1, the areas of tertiary planning units (i.e., TPU) with more restaurants are found to be positively associated with the period of the prevalence of COVID-19. In Phase 2, restaurants and public markets induce long time occurrence of the COVID-19. (3) In Phase 1, restaurant and public markets are the two built environments that influence the number of COVID-19 confirmed cases. In Phase 2, the number of restaurants is positively related to the number of COVID-19 reported cases. It is suggested that governments should not be too optimistic to relax the necessary measures.
Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC	Yoon,  Hyun ah,  Bartash, et al	medRxiv	Clinical data| Données cliniques Therapeutics| Thérapeutique	Compared the mortality and clinical outcome of patients with COVID-19 who received 200mL of convalescent plasma (CCP) with a Spike protein IgG titer ≥1:2,430 (median 1:47,385) within 72 hours of admission to propensity score-matched controls cared for at a medical center in the Bronx, between April 13 to May 4, 2020. There was no difference in mortality or oxygenation between CCP recipients and controls at day 28. When stratified by age, compared to matched controls, CCP recipients <65 years had 4-fold lower mortality and 4-fold lower deterioration in oxygenation or mortality at day 28. For CCP recipients, pre-transfusion Spike protein IgG, IgM and IgA titers were associated with mortality at day 28 in univariate analyses. No adverse effects of CCP were observed. Our results suggest CCP may be beneficial for hospitalized patients <65 years, but data from controlled trials is needed to validate this finding and establish the effect of ageing on CCP efficacy.
Reactive, Agentic, Apathetic, or Challenged? Aging, Emotion, and Coping During the COVID-19 Pandemic	Young,  NA,  Waugh, et al	Gerontologist	Mental Health | santé mentale	Investigated differences in emotional experiences and coping strategies between younger and older adults during the pandemic, and whether these differences were accounted for by age differences in appraisal of the pandemic. Results indicated that older adults experienced less stress and less negative affect and used greater problem-focused coping and less avoidant coping in response to the pandemic than younger adults. Further, age differences in affect and coping were partially accounted for by age differences in appraisals of the pandemic.
Insulin Treatment Is Associated with Increased Mortality in Patients with COVID-19 and Type 2 Diabetes	Yu,  B,  Li, et al	Cell Metabolism	Epidemiology| Épidémiologie Clinical data| Données cliniques	COVID-19 caused by SARS-COV-2 infection can lead to multi-organ injuries and significant mortality in severe and critical patients, especially among those individuals with type 2 diabetes (T2D) as a comorbidity. While attenuated mortality was observed with aggressive glucose control, it was unclear whether therapeutic regimens including insulin treatment were beneficial for patients with COVID-19 and T2D. This retrospective study investigated 689 patients with COVID-19 and T2D from a cohort of 3,305 cases from Wuhan, China. Unexpectedly, we found that insulin treatment for patients with COVID-19 and T2D was associated with a significant increase in mortality (27.2% versus 3.5%; adjusted HR, 5.38 2.75–10.54]). Further analysis showed that insulin treatment was associated with enhanced systemic inflammation and aggravated injuries of vital organs. Therefore, insulin treatment for patients with COVID-19 and T2D should be used with caution. © 2020 Elsevier Inc. Type 2 diabetes (T2D) is associated with poor outcome for patients with COVID-19. Here, Yu et al. demonstrated that among 689 patients with T2D from a cohort of 3,305 hospitalized COVID-19 cases, insulin treatment was associated with a significant increase in death rate in patients with COVID-19 and T2D. © 2020 Elsevier Inc.
Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection	Yu,  R,  Tan, et al	Virology	Clinical data| Données cliniques	In patients coinfected with SARS-CoV-2 and HBV, liver injury was common. However, the interactions between SARS-CoV-2 and HBV coinfection remained unknown. Sixty-seven COVID-19 patients from the previous cohort were enrolled and classified into 2 groups (7 with HBsAg+ and 60 with HBsAg-). The association of HBV- and SARS-CoV-2-related markers were analyzed. During the acute course of SARS-CoV-2 infection, markers of HBV replication did not extensively fluctuate during SARS-CoV-2 infection. Coinfection with HBV did not extend the viral shedding cycle or incubation periods of SARS-CoV-2. Effects of SARS-CoV-2 on the dynamics of chronic HBV infection seemed not apparent. SARS-CoV-2 infection would not be the source of HBV reactivation in these individuals. © 2020
Non-linear correlation between daily new cases of COVID-19 and meteorological factors in 127 countries	Yuan,  J,  Wu, et al	Environ Res	Epidemiology| Épidémiologie	Investigated the effects of meteorological factors on daily new cases of COVID-19 in 127 countries, as of August 31 2020. Our findings revealed that temperature, relative humidity, and wind speed are nonlinearly correlated with daily new cases, and they may be negatively correlated with the daily new cases of COVID-19 over 127 countries when temperature, relative humidity and wind speed were below 20°C, 70% and 7m/s respectively. Temperature(>20°C) was positively correlated with daily new cases. Wind speed (when>7m/s) and relative humidity (>70%) was not statistically associated with transmission of COVID-19.
Frequency of Positive Aspergillus Tests in COVID-19 Patients in Comparison to Other Patients with Pulmonary Infections Admitted to the ICU	Yusuf,  E,  Vonk, et al	J Clin Microbiol	Epidemiology| Épidémiologie Clinical data| Données cliniques	Describe the frequency of positive Aspergillus tests in COVID-19 patients and investigate the association between COVID-19 and a positive Aspergillus test result. 92 COVID-19 patients (mean age (SD) 62(14) years, 76.1% males), 48 influenza (55(14), 56.2% males), and 65 pneumococcal pneumonia (58 (15), 63,1% males) patients were identified. Any positive Aspergillus test from any respiratory sample was found in 10.9% of the COVID-19 patients, 6.2% of the patients with pneumococcal pneumonia and 22.9% of those infected with influenza. A positive culture or PCR or galactomannan test on bronchoalveolar lavage fluid (BAL) only was found in 5.4% of COVID-19 patients, which was lower than in patients with influenza (18.8%) and comparable to pneumococcal pneumonia group (4.6%). Using logistic regression analysis, the odds ratio, OR (95% CI) for a positive Aspergillus test on BAL fluid for COVID19 patients was 1.2 (0.3 to 5.1, p=0.8) compared to the pneumococcal pneumonia group while it was 0.2 (0.1 to 0.8, p=0.02) compared with influenza group. This difference remained significant when corrected for age and sex. In conclusion, in COVID19 patients, the prevalence of a positive aspergillus test was comparable to patients with admitted for pneumococcal pneumonia but substantially lower than what we observed in patients with influenza.
Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures	Zafferani,  Martina,  Haddad, et al	bioRxiv	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, has rendered our understanding of coronavirus biology more essential than ever. Small molecule chemical probes offer to both reveal novel aspects of virus replication and to serve as leads for antiviral therapeutic development. The RNA-biased amiloride scaffold was recently tuned to target a viral RNA structure critical for translation in enterovirus 71, ultimately uncovering a novel mechanism to modulate positive-sense RNA viral translation and replication. Analysis of CoV RNA genomes reveal many conserved RNA structures in the 5'-UTR and proximal region critical for viral translation and replication, including several containing bulge-like secondary structures suitable for small molecule targeting. Following phylogenetic conservation analysis of this region, we screened an amiloride-based small molecule library against a less virulent human coronavirus, OC43, to identify lead ligands. Amilorides inhibited OC43 replication as seen in viral plaque assays. Select amilorides also potently inhibited replication competent SARS-CoV-2 as evident in the decreased levels of cell free virions in cell culture supernatants of treated cells. Reporter screens confirmed the importance of RNA structures in the 5'-end of the viral genome for small molecule activity. Finally, NMR chemical shift perturbation studies of the first six stem loops of the 5'-end revealed specific amiloride interactions with stem loops 4, 5a, and 6, all of which contain bulge like structures and were predicted to be strongly bound by the lead amilorides in retrospective docking studies. Taken together, the use of multiple orthogonal approaches allowed us to identify the first small molecules aimed at targeting RNA structures within the 5'-UTR and proximal region of the CoV genome. These molecules will serve as chemical probes to further understand CoV RNA biology and can pave the way for the development of specific CoV RNA-targeted antivirals.Competing Interest StatementThe authors have declared no competing interest.
The feasibility of patients with coronavirus disease wearing N95 respirators during induction of anaesthesia	Zhang,  C,  Xu, et al	Anaesthesia Critical Care and Pain Medicine	Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé	Investigated the effect of N95 respirators on ventilation. Wearing a N95 respirator increased airway resistance. As the airway pressure was limited, even if the tidal volume was adjusted, there was still little gas that can enter the patient’s lungs. Due to the limitation of airway resistance, setting a high tidal volume may cause the increase of pressure in the breathing circuit and more gas will leak out.
The Impact of the COVID-19 Pandemic on Pediatric Clinical Practice in Wenzhou, China: A Retrospective Study	Zhang,  H,  Guo, et al	Frontiers in Pediatrics	Healthcare Response | Réponse des soins de santé	Report on the impact of COVID-19 on the pediatric health care system at a pediatric tertiary hospital in Wenzhou. The total number of outpatient cases in the previous 22 weeks of the year declined from 560,620 in 2019 to 247,030 in 2020, and inpatient cases decreased from 14,177 to 7,555. This negative trend settled by week 6 and 7 and subsequently approached the 2019 numbers. The most noticeable decrease in the number of cases was observed in children of preschool age. Moreover, the number of weekly visits decreased at the beginning of the epidemic, reached the lowest value during the lockdown period, and recovered after the lockdown.
The mental health of chinese healthcare staff in non-epicenter of covid-19: A cross-sectional study	Zhang,  L,  Wang, et al	Annals of Palliative Medicine	Mental Health | santé mentale	Investigate the psychological status of medical staff in a women and children’s hospital in non-epicenter of COVID-19 during the early stage of the COVID-19 outbreak. Eligible responses were received from 1,890 (90.6%) women and 197 (9.4%) men. In total, 10.3% of respondents rated the psychological impact of the outbreak as moderate or severe, and 4% reported severe anxiety symptoms. Our findings indicated that the majority of the medical staff are in great level of mental health. The study demonstrates that females, the 31–40 age group, and those who have been widowed experienced greater levels of anxiety and therefore require more support.
PMC7708802; Higher pharyngeal epithelial gene expression of Angiotensin-Converting Enzyme-2 in upper respiratory infection patients	Zhang,  M,  Du, et al	Int J Infect Dis	Clinical data| Données cliniques	We analyzed the expression of ACE2 in pharyngeal epithelium and examined its relationship with clinical features and serological parameters in the upper respiratory infection (URI) patients. The expression level of ACE2 gene was significantly higher in URI patients (n = 125) than in Healthy control (HC) individuals (n = 52) (p < 0.0001). ACE2 gene expression level was significantly and positively correlated with age (r=0.1799, p = 0.0447) and body temperature (r=0.1927, p = 0.0427), which may help explain increasing coinfections with SARS-CoV-2 and other respiratory pathogens.
PMC7709789; Thyroid dysfunction may be associated with poor outcomes in patients with COVID-19	Zhang,  Y,  Lin, et al	Mol Cell Endocrinol	Clinical data| Données cliniques	Investigate the prevalence of thyroid dysfunction (TD) and its association with the prognosis of COVID-19. A total of 25 and 46 COVID-19 patients with and without TD, respectively, were included in the study. COVID-19 patients with TD had significantly higher neutrophil counts and higher levels of C-reactive protein, procalcitonin, lactate dehydrogenase, serum creatine kinase, aspartate transaminase, and high-sensitive troponin I and a longer activated partial thromboplastin time but lower lymphocyte, platelet, and eosinophil counts. A longitudinal analysis of serum biomarkers showed that patients with TD presented persistently high levels of biomarkers for inflammatory response and cardiac injury. COVID-19 patients with TD were more likely to develop a critical subtype of the disease. Patients with TD had a significantly higher fatality rate than did those without TD during hospitalisation (20% vs 0%). Patients with TD were more likely to stay in the hospital for more than 28 days than were those without TD (80% vs 56.52%).
Application value of post-discharge chest low-dose CT for patients with COVID-19	Zhang,  Y,  Liu, et al	Chinese Journal of Radiological Medicine and Protection	Clinical data| Données cliniques	Explored the value of chest low-dose CT (LDCT) in post-discharge follow-up assessments of patients with coronavirus disease 2019 (COVID-19). The subjective image quality scores on CT images obtained before and after discharge by readers 1 and 2, were 4.45±0.22, 3.88±0.33 and 4.37±0.18, 3.91±0.35, respectively. The SNR and SDair in LDCT after discharge were 4.39±0.95 and 7.19±2.41, which were significantly lower than those in routine chest CT before discharge (5.14±1.06, Z=-5.551; 6.48±1.57, Z=-3.217). All of the obtained images were sufficient for diagnosis. The CTDIvol, DLP, and E in LDCT were significantly lower than those in routine CT (2.41±0.09), (10.53±1.03); (88.03±5.33), (338.74±34.64); and (1.23±0.17), (4.74±0.48).
Clinical Characteristics of Patients With Progressive and Non-progressive Coronavirus Disease 2019: Evidence From 365 Hospitalised Patients in Honghu and Nanchang, China	Zhang,  Y,  Xiao, et al	Frontiers in Medicine	Epidemiology| Épidémiologie Clinical data| Données cliniques	Analyzed the differences in clinical characteristics between patients with progressive and non-progressive COVID-19 and to determine the risk factors for disease progression. Compared with patients with non-progressive disease, those who progressed to severe COVID-19 were older and had significantly decreased lymphocyte and eosinophil counts; increased neutrophil and platelet counts; lower albumin levels; higher levels of lactate dehydrogenase, C-reactive protein (CRP), creatinine, creatinine kinase, and urea nitrogen; and longer prothrombin times. Hypertension, fever, fatigue, anorexia, bacterial coinfection, bilateral patchy shadowing, antibiotic and corticosteroid administration, and oxygen support had a significantly higher incidence among patients with progressive disease. A significantly longer duration of hospital stay was also observed in patients with progressive disease. Bilateral patchy shadowing (OR = 4.82) and elevated levels of creatinine (OR =6.24), and CRP (OR = 7.28) were independent predictors for disease progression.
Crowding effects on the dynamics of COVID-19 mathematical model	Zhang,  Z,  Zeb, et al	Advances in Difference Equations	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	A disastrous coronavirus, which infects a normal person through droplets of infected person, has a route that is usually by mouth, eyes, nose or hands. These contact routes make it very dangerous as no one can get rid of it. The significant factor of increasing trend in COVID19 cases is the crowding factor, which we named “crowding effects”. Modeling of this effect is highly necessary as it will help to predict the possible impact on the overall population. The nonlinear incidence rate is the best approach to modeling this effect. At the first step, the model is formulated by using a nonlinear incidence rate with inclusion of the crowding effect, then its positivity and proposed boundedness will be addressed leading to model dynamics using the reproductive number. Then to get the graphical results a nonstandard finite difference (NSFD) scheme and fourth order Runge–Kutta (RK4) method are applied. © 2020, The Author(s).
Prevalence and related risk factors of psychotic symptoms among inpatients infected with COVID-19 during the second wave pandemic	Zhang,  Zhiyang,  Feng, et al	Research Square prepub	Clinical data| Données cliniques Mental Health | santé mentale	Explored the prevalence of and related risk factors associated with psychotic symptoms in COVID-19 infected inpatients during the second wave. Among 199 infected participants, the prevalence of generalized anxiety symptoms is 51.3%, of depressive symptoms 41.2%, of PTSD symptoms 33.6%. Loneliness, hope, coping strategies, history of mental disorders were shared risk or protective factors across several psychotic symptoms. Perceived impact by COVID-19 is the specific risk factor associated with state anxiety symptoms.
Tocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample size	Zhao,  H,  Zhu, et al	Biomedicine and Pharmacotherapy	Clinical data| Données cliniques Therapeutics| Thérapeutique	Assessed the efficacy and safety of tocilizumab combined with favipiravir in patients with COVID-19.  Between Feb 2 and March 15, 2020, 26 patients were recruited; 14 were randomly assigned to the combination group, 7 were assigned to the favipiravir group and 5 were assigned to the tocilizumab group. The cumulative lung lesion remission rate at day 14 was significantly higher in combination group as compared with favipiravir group (HR 2.66). And there was also a significant difference between tocilizumab and favipivavir (HR 3.16). In addition, there was no significant difference between the combination group and the tocilizumab group (HR 1.28). Furthermore, combined therapy can also significantly relieve clinical symptoms and help blood routine to return to normal. No serious adverse events were reported.
SARS-CoV-2-induced immune activation and death of monocyte-derived human macrophages and dendritic cells	Zheng,  J,  Wang, et al	J Infect Dis	Clinical data| Données cliniques	Studies of SARS-CoV-2-infected patients and experimentally infected animals indicate a critical role for augmented expression of pro-inflammatory chemokines and cytokines in severe disease. Here, we demonstrate that SARS-CoV-2 infection of human monocyte-derived macrophages (MDMs) and dendritic cells (MDDCs) was abortive, but induced the production of multiple antiviral and pro-inflammatory cytokines (IFN-α, IFN-β, TNF, IL-1β, IL-6 and IL-10) and a chemokine (CXCL10). Despite the lack of efficient replication in MDMs, SARS-CoV-2 induced profound IFN-mediated cell death of host cells. Macrophage activation and death was not enhanced by exposure to low levels of convalescent plasma, suggesting that antibody-dependent enhancement of infection does not contribute to cell death. Together, these results indicate that infection of macrophages and dendritic cells potentially plays a major role in COVID-19 pathogenesis, even in the absence of productive infection.
Proton pump inhibitor or famotidine use and severe COVID-19 disease: a propensity score-matched territory-wide study	Zhou,  J,  Wang, et al	Gut	Clinical data| Données cliniques Therapeutics| Thérapeutique	Conducted this territory-wide study to investigate whether proton pump inhibitor (PPI) or famotidine use was associated with a higher risk of severe disease using propensity score matching. The percentage of COVID-19 patients meeting the primary outcome was significantly higher in PPI users than in non-users, both before (28.8% vs 1.6%) and after 1:5 propensity score matching for age, sex, medical comorbidities and medication history (28.8% vs 6.6%). Similarly, famotidine users also showed a higher percentage compared with non-users before (13.9% vs 3.6%) and after matching (13.9% vs 7.6%). Univariable Cox regression showed that the use of PPI (HR: 6.32) or famotidine (HR: 1.98) was associated with a higher risk of the primary outcome. On multivariable Cox regression adjusting for age, cardiovascular disease, renal disease, stroke, Kaletra, diuretics for heart failure, other anti-hypertensives, PPI/famotidine, neutrophils, lymphocytes, platelets, urea, creatinine, albumin and glucose, the associations remained significant for both PPI (HR: 2.73) and famotidine (HR: 1.81).
Analysis of the path from discovery of novel coronavirus disease 2019 cases to its diagnosis in Shaanxi Province	Zhu,  N,  Chen, et al	Journal of Xi'an Jiaotong University (Medical Sciences)	Epidemiology| Épidémiologie Transmission	Article in Chinese. Explore the problems and experience in the prevention and control of novel coronavirus disease 2019 (COVID-19) by analyzing the path from its discovery to its diagnosis in Shaanxi Province. Totally 72.65% of the confirmed COVID-19 cases in Shaanxi Province were not in isolation or management at the time of onset, which resulted in an infection rate of 1.37% in close-knit populations. The duration between the onset of local COVID-19 cases in Shaanxi and the delay in confirmed diagnosis was relatively long (6.30 days), and the mean incubation period was 7.27 days. The delay time (7.29 days) between onset and diagnosis of preepidemic cases was longer than that (6.19 days) of later epidemic cases.
PMC7708232; Micro-RNAs in the regulation of immune response against SARS COV-2 and other viral infections	Abu-Izneid,  T,  AlHajri, et al	J Adv Res	Review Literature| Revue de littérature
Histopathological basis of COVID-19: A short review	Adhya,  S	Indian Journal of Biochemistry and Biophysics	Review Literature| Revue de littérature
Surveillance of SARS-CoV-2 RNA in wastewater: Methods optimization and quality control are crucial for generating reliable public health information	Ahmed,  W,  Bivins, et al	Current Opinion in Environmental Science and Health	Review Literature| Revue de littérature
Association of ace expression among hypertension patients in Covid - 19 pandemic	Akshayaa,  L,  Girija, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
PMC7700766; Toward establishing telepsychology guideline. Turning the challenges of COVID-19 into opportunity	Alqahtani,  MMJ,  Alkhamees, et al	Ethics Med Public Health	Review Literature| Revue de littérature
Molecular medicine in the current scenario of COVID-19; A clinical and radiological study	Alshehri,  FM,  Gilbert, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Analytical methodologies for the detection of SARS-CoV-2 in wastewater: Protocols and future perspectives	Alygizakis,  N,  Markou, et al	TrAC - Trends in Analytical Chemistry	Review Literature| Revue de littérature
Implementation of High-Sensitivity and Point-of-Care Cardiac Troponin Assays into Practice: Some Different Thoughts	Apple,  FS,  Fantz, et al	Clin Chem	Review Literature| Revue de littérature
SARS-CoV-2, ACE2 expression, and systemic organ invasion	Ashraf,  UM,  Abokor, et al	Physiol Genomics	Review Literature| Revue de littérature
A review of guidelines to resuming elective orthopaedic surgeries amid covid-19 pandemic: Deriving a simple traffic light model	Attia,  AK,  Omar, et al	Malaysian Orthopaedic Journal	Review Literature| Revue de littérature
COVID-19 Impacts, Diagnosis and Possible Therapeutic Techniques: A Comprehensive Review	Aziz,  A,  Asif, et al	Curr Pharm Des	Review Literature| Revue de littérature
PMC7711169; AIR quality and COVID-19 adverse outcomes: Divergent views and experimental findings	Becchetti,  L,  Beccari, et al	Environ Res	Review Literature| Revue de littérature
State of science: the future of work–ergonomics and human factors contributions to the field	Bentley,  T,  Green, et al	Ergonomics	Review Literature| Revue de littérature
Why individuals with cerebral palsy are at higher risk for respiratory complications from COVID-19	Brandenburg,  JE,  Fogarty, et al	Journal of pediatric rehabilitation medicine	Review Literature| Revue de littérature
Remote clinics in gastroenterology: A literature review of telephone and video consultations in adult and paediatric services	Brooks,  M,  Cund, et al	Gastrointestinal Nursing	Review Literature| Revue de littérature
The interplay between HIV and COVID-19: summary of the data and responses to date	Brown,  LB,  Spinelli, et al	Curr Opin HIV AIDS	Review Literature| Revue de littérature
British Journal of Biomedical Science in 2020. What have we learned?	Brown,  NW,  Orchard, et al	British journal of biomedical science	Review Literature| Revue de littérature
Diabetes Mellitus is Associated with Severe Infection and Mortality in Patients with COVID-19: A Systematic Review and Meta-analysis	Bud,  ES,  Vlasa, et al	Archives of Medical Research	Review Literature| Revue de littérature	SR-MA: systematically searched the PubMed, Web of Science, MedRxiv and COVID-19 academic research communication platform for studies reporting clinical severity and/or overall mortality data on DM in patients with COVID-19 published up to July 10, 2020. DM is associated with increased risk of severe infection and higher mortality in patients with COVID-19. Our study suggests that clinicians should pay more attention to the monitoring and treatment of COVID-19 patients with DM.
Covid-19 and inequality: developing an age-friendly strategy for recovery in low income communities	Buffel,  T,  Doran, et al	Quality in Ageing and Older Adults	Review Literature| Revue de littérature
Six months into the pandemic. A review of skin manifestations in SARS-CoV-2 infection	Burlando,  M,  Russo, et al	Dermatol Ther	Review Literature| Revue de littérature
Bio-Inspired Systems in Nonsurgical Periodontal Therapy to Reduce Contaminated Aerosol during COVID-19: A Comprehensive and Bibliometric Review	Butera,  A,  Maiorani, et al	J Clin Med	Review Literature| Revue de littérature
A review of COVID-19 biomarkers and drug targets: resources and tools	Caruso,  FP,  Scala, et al	Brief Bioinform	Review Literature| Revue de littérature
FDA efficiency for approval process of COVID-19 therapeutics	Cassidy,  C,  Dever, et al	Infectious Agents and Cancer	Review Literature| Revue de littérature
Coronavirus disease 2019 and type 1 diabetes mellitus	Chang,  DJ,  Moin, et al	Curr Opin Endocrinol Diabetes Obes	Review Literature| Revue de littérature
Infection-prevention measures against COVID-19 during anesthesia: A narrative review of current clinical literature	Chen,  Y,  Guo, et al	Annals of Palliative Medicine	Review Literature| Revue de littérature
Sustainable food supply chains: Is shortening the answer? a literature review for a research and innovation agenda	Chi Ffoleau,  Y,  Dourian, et al	Sustainability (Switzerland)	Review Literature| Revue de littérature
Next generation sequencing of SARS-CoV-2 genomes: challenges, applications and opportunities	Chiara,  M,  D'Erchia, et al	Brief Bioinform	Review Literature| Revue de littérature
Lessons learnt from the Covid-19 pandemic in Italy	Choudhary,  A,  Smiline Girija, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
PMC7709793; The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options	Choudhary,  S,  Sharma, et al	Microb Pathog	Review Literature| Revue de littérature
Implementation of the Stroke Action Plan for Europe 2018-2030 during coronavirus disease-2019	Christensen,  H,  Pezzella, et al	Curr Opin Neurol	Review Literature| Revue de littérature
Impact of COVID-19 on the gravity and prognosis of individuals with obesity: A systematic review	de Araújo,  TA,  de Moura, et al	Revista Pesquisa em Fisioterapia	Review Literature| Revue de littérature	SR: searched for observational studies through the PubMed databases, the VHL Regional Portal, SciELO, Science Direct and Cochrane. Individuals with obesity develop greater severity and worse prognosis for COVID-19, since there is an increase in admission rates for acute and mandatory care, need for IMV, length of hospital stay, severity and lethality.
Risk factors for severe illness and death in COVID-19: a systematic review and meta-analysis	Degarege,  Abraham,  Naveed, et al	medRxiv	Review Literature| Revue de littérature	SR-MA: searched literature from PubMed, Embase, Cochrane library and CINHAL on May 6, 2020. Older age and chronic diseases increase the risk of developing severe illness, admission to ICU and death among COVID-19 patients. Special strategies are warranted to prevent SARS-CoV-2 infection and manage COVID-19 cases in those with vulnerabilities.
Exploring the Motivation Behind Discrimination and Stigmatization Related to COVID-19: A Social Psychological Discussion Based on the Main Theoretical Explanations	Demirtaş-Madran,  HA	Frontiers in Psychology	Review Literature| Revue de littérature
Coronavirus disease 2019: scientific overview of the global pandemic	Dey,  A,  Das, et al	New Microbes and New Infections	Review Literature| Revue de littérature
Recommended medications for N-COV disease - a review	Dhayanithi,  J,  Smiline Girija, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Obesityas a major risk factor in N-COV disease	Dhivyadharshini,  J,  Girija, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Composition and uses of N95 masks -a review	Dhivyadharshini,  J,  Somasundaram, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Reporting and design of randomized controlled trials for COVID-19: A systematic review	Dillman,  A,  Park, et al	Contemp Clin Trials	Review Literature| Revue de littérature	SR: conducted three searches to identify registered clinical trials, peer-reviewed publications, and pre-print publications. The findings of our study highlight limitations in the design and reporting practices of COVID-19 RCTs and provide guidance towards more efficient reporting of trial results, greater diversity in patient settings, and more robust data sharing.
Lesions in the lungs of fatal corona virus disease Covid-19	Englisch,  CN,  Tschernig, et al	Ann Anat	Review Literature| Revue de littérature
COVID-19 reinfection: prolonged shedding or true reinfection?	Falahi,  S,  Kenarkoohi, et al	New Microbes and New Infections	Review Literature| Revue de littérature
Genetic analysis of the 2019 coronavirus pandemic with from real-time reverse transcriptase polymerase chain reaction	Farasani,  A	Saudi Journal of Biological Sciences	Review Literature| Revue de littérature
De-escalating cancer treatments during COVID 19 pandemic: Is metronomic chemotherapy a reasonable option?	Fedele,  P,  Sanna, et al	Critical reviews in oncology/hematology	Review Literature| Revue de littérature
Drivers of mortgage spreads across the business and housing cycle	Fout,  H,  Duncan, et al	Journal of Structured Finance	Review Literature| Revue de littérature
Institution-Specific Strategies for Head and Neck Oncology Triage During the COVID-19 Pandemic	Freeman,  MH,  Shinn, et al	Ear Nose Throat J	Review Literature| Revue de littérature
Impact of non-pharmaceutical interventions targeted at COVID-19 pandemic on influenza burden - a systematic review	Fricke,  LM,  Glöckner, et al	J Infect	Review Literature| Revue de littérature	SR: systematic literature search in selected databases (PubMed, WHO COVID-19), preprint servers (medRxiv, bioRxiv) and websites of European Public Health institutes. Documents that compared influenza estimates in the 2019/2020 season with previous seasons were included. Evidence synthesis suggests that NPIs targeted at SARS-CoV-2-transmission reduce influenza burden as well. Low threshold NPIs need to be more strongly emphasized in influenza prevention strategies.
Origin and genomic characteristics of SARS-CoV-2 and its interaction with angiotensin converting enzyme type 2 receptors, focusing on the gastrointestinal tract	Galanopoulos,  M,  Doukatas, et al	World Journal of Gastroenterology	Review Literature| Revue de littérature
Academic standards and quality assurance: the impact of covid-19 on university degree programs	Gamage,  KAA,  Roshan Pradeep, et al	Sustainability (Switzerland)	Review Literature| Revue de littérature
Origin, evolution and history of covid 19 - a review	Ganesh,  S,  Jothi Priya, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Covid-19: Its incidence and recovery among global population - A review	Ganesh,  S,  Prathap, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
The COVID-19 effect in mexican SMEs	García-Villagrán,  A,  Cano-Olivos, et al	Advances in Science, Technology and Engineering Systems	Review Literature| Revue de littérature
Endocrine involvement in COVID-19: Mechanisms, clinical features, and implications for care	Garg,  MK,  Gopalakrishnan, et al	Indian Journal of Endocrinology and Metabolism	Review Literature| Revue de littérature
Structural basis of severe acute respiratory syndrome coronavirus 2 infection	Ge,  J,  Zhang, et al	Curr Opin HIV AIDS	Review Literature| Revue de littérature
Gastrointestinal and Hepatic Involvement in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Review	Ghoshal,  UC,  Ghoshal, et al	Journal of Clinical and Experimental Hepatology	Review Literature| Revue de littérature
Home-based exercise can be beneficial for counteracting sedentary behavior and physical inactivity during the COVID-19 pandemic in older adults	Ghram,  A,  Briki, et al	Postgrad Med	Review Literature| Revue de littérature
Understanding the dynamics of the covid-19 pandemic: A real-time analysis of switzerland’s first wave	Giachino,  M,  Valera, et al	International Journal of Environmental Research and Public Health	Review Literature| Revue de littérature
Impact of Covid-19 on undergraduate and residency training	Giordano,  L,  Cipollaro, et al	Surgeon	Review Literature| Revue de littérature
The Risk of COVID-19 Pandemic in Patients with Moderate to Severe Plaque Psoriasis Receiving Systemic Treatments	Gisondi,  P,  Bellinato, et al	Vaccines (Basel)	Review Literature| Revue de littérature
Safety in the practice of decontaminating filtering facepiece respirators: A systematic review	Gnatta,  JR,  de Souza, et al	Am J Infect Control	Review Literature| Revue de littérature	SR: PubMed, CINAHL, LILACS, CENTRAL, EMBASE, Web of Science and Scopus.  There is a complex relationship between the FFR raw materials and the cycle conditions of the decontamination methods, evidencing the need for validating FFRs by models and manufacturers, as well as the process.
Emerging cellular and pharmacologic therapies for acute respiratory distress syndrome	Gonzalez,  H,  Horie, et al	Curr Opin Crit Care	Review Literature| Revue de littérature
Living a life less ordinary: what can the families of essential workers responding to covid-19 learn from uk military families?	Gribble,  R,  Connelly, et al	Journal of Military, Veteran and Family Health	Review Literature| Revue de littérature
Effects of breathing exercises and incentive spirometry in improving lung capacity on individuals with lung fibrosis	Gugnani,  A	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Economic declination due to COVID-19 lockdown - a review	Guntupalli,  Y,  Jothi Priya, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Tobacco use as a well-recognized cause of severe COVID-19 manifestations	Gupta,  AK,  Nethan, et al	Respiratory medicine	Review Literature| Revue de littérature
Dcs-based therapies: Potential strategies in severe sars-cov-2 infection	Han,  J,  Sun, et al	International Journal of Medical Sciences	Review Literature| Revue de littérature
Utilizing microbiome approaches to assist source tracking, treatment and prevention of COVID-19: Review and assessment	Han,  M,  Zha, et al	Computational and Structural Biotechnology Journal	Review Literature| Revue de littérature
Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms	He,  YQ,  Zhou, et al	Pharmacological Research	Review Literature| Revue de littérature
CT chest findings in patients infected with COVID-19: review of literature	Hefeda,  MM	Egyptian Journal of Radiology and Nuclear Medicine	Review Literature| Revue de littérature
Challenges faced by China on covid-19	Hiranya,  S,  Jothi Priya, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Perspective adjunctive therapies for COVID-19: Beyond antiviral therapy	Ho,  P,  Zheng, et al	International Journal of Medical Sciences	Review Literature| Revue de littérature
Hunting coronavirus by transmission electron microscopy – a guide to SARS-CoV-2-associated ultrastructural pathology in COVID-19 tissues	Hopfer,  H,  Herzig, et al	Histopathology	Review Literature| Revue de littérature
Prevalence and clinical outcomes of cardiac injury in patients with COVID-19: A systematic review and meta-analysis	Huang,  Z,  Huang, et al	Nutrition, Metabolism and Cardiovascular Diseases	Review Literature| Revue de littérature	SR-MA: Literature search was conducted through PubMed, the Cochrane Library, Embase, and MedRxiv databases. The prevalence of cardiac injury was greatly increased in COVID-19 patients, particularly in patients with severe disease and non-survivors. COVID-19 patients with cardiac injury are more likely to be associated with poor outcomes, severity of disease, admission to ICU, and mortality.
Biomolecular endotype factors involved in COVID-19 airway infectivity: A systematic review	Jain,  N,  Varman, et al	Auris Nasus Larynx	Review Literature| Revue de littérature	SR: literature search of PubMed and Google Scholar for articles published between January 1, 2002 to May 31, 2020. Further research is needed to understand the effects of Vitamin D and the various cytokines prevalent among endotypes of nasal/pharyngeal illnesses on COVID-19 pathogenesis. Findings may point towards epidemiologic trends of SARS-CoV-2 transmission and have future therapeutic indications.
Pandemic outbreak of Covid-19 and history of other pandemic outbreak in past centuries: A review	Jose,  SM,  Prathap, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
THE THERAPEUTIC POTENTIAL OF IVERMECTIN FOR COVID-19: A SYSTEMATIC REVIEW OF MECHANISMS AND EVIDENCE	Kalfas,  Stefanie,  Visvanathan, et al	medRxiv	Review Literature| Revue de littérature	SR: comprehensive review of PubMed, medRxiv, ClinicalTrials.gov, Global Coronavirus COVID-19 Clinical Trial Tracker, World Health Organization International Clinical Trials Registry Platform, EU Clinical Trials Register, ANZ clinical trials registry, and references from relevant articles.  Positive mortality benefit, reduced time to clinical recovery, reduced incidence of disease progression and decreased duration of hospital admission were reported in patients across all stages of clinical severity.
Advantages and disadvantages of RT- PCR in COVID 19	Kameswari,  S,  Brundha, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
COVID-19 vaccine development: a pediatric perspective	Kamidani,  S,  Rostad, et al	Curr Opin Pediatr	Review Literature| Revue de littérature
COVID-19 as cause of viral sepsis: A Systematic Review and Meta-Analysis	Karakike,  Eleni,  Giamarellos-Bourboulis, et al	medRxiv	Review Literature| Revue de littérature	SR-MA: Data sources MEDLINE(PubMed), Cochrane and Google Scholar databases. Despite the high heterogeneity in reported results, sepsis frequently complicates COVID-19 among hospitalized patients and is significantly higher among those in the ICU.
Recent advances in sensitive surface-enhanced Raman scattering-based lateral flow assay platforms for point-of-care diagnostics of infectious diseases	Kim,  K,  Kashefi-Kheyrabadi, et al	Sensors and Actuators, B: Chemical	Review Literature| Revue de littérature
Cholesterol, lipoproteins, and COVID-19: Basic concepts and clinical applications	Kočar,  E,  Režen, et al	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids	Review Literature| Revue de littérature
The end of over-tourism? Opportunities in a post-Covid-19 world	Koh,  E	International Journal of Tourism Cities	Review Literature| Revue de littérature
Advances in developing small molecule SARS 3CLpro inhibitors as potential remedy for corona virus infection	Konwar,  M,  Sarma, et al	Tetrahedron	Review Literature| Revue de littérature
Impact and role of asymptomatic, pre-symptomatic and mild-symptomatic patients on SARS-CoV-2 transmission in COVID-19 pandemic	Kumar,  A,  Palit, et al	Journal of the Indian Chemical Society	Review Literature| Revue de littérature
Economic impact assessment of SARS-CoV-2 on Global Markets	Kumar,  J,  Prajapati, et al	Annals of Tropical Medicine and Public Health	Review Literature| Revue de littérature
PMC7709475; Selection of animal models for COVID-19 research	Kumar,  S,  Yadav, et al	Virusdisease	Review Literature| Revue de littérature
Effect of ayurvedic medicines on Covid-19 affected patients	Kumari,  S,  Gheena, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Epidemiological Peculiarities of New Coronavirus Infection (COVID-2019). Communication 2: Peculiarities of epidemic process development in conjunction with performed anti-epidemic measures around the world and in the Russian Federation	Kutyrev,  VV,  Popova, et al	Problemy Osobo Opasnykh Infektsii	Review Literature| Revue de littérature
PMC7716795; Host genetics and infectious disease: new tools, insights and translational opportunities	Kwok,  AJ,  Mentzer, et al	Nat Rev Genet	Review Literature| Revue de littérature
How is the COVID-19 pandemic affecting global supply chains, logistics, and transportation?	Kwon,  OK	Journal of International Logistics and Trade	Review Literature| Revue de littérature
Antibody-guided structure-based vaccines	Kwong,  PD,  DeKosky, et al	Seminars in immunology	Review Literature| Revue de littérature
Potential molecular targets of nonstructural proteins for the development of antiviral drugs against SARS-CoV-2 infection	Liu,  XH,  Zhang, et al	Biomedicine and Pharmacotherapy	Review Literature| Revue de littérature
Stroke epidemiology and COVID-19 pandemic	Logroscino,  G,  Beghi, et al	Curr Opin Neurol	Review Literature| Revue de littérature
Molecular epidemiology in the HIV and SARS-CoV-2 pandemics	Lorenzo-Redondo,  R,  Ozer, et al	Curr Opin HIV AIDS	Review Literature| Revue de littérature
The impact of lockdown on the health of the elderly during the COVID-19 pandemic	Maamar,  M,  Khibri, et al	NPG Neurologie - Psychiatrie - Geriatrie	Review Literature| Revue de littérature
Guidelines for oral and maxillofacial imaging: COVID-19 considerations	MacDonald,  DS,  Colosi, et al	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology	Review Literature| Revue de littérature
Challenges, limitations, and solutions for orthodontists during the coronavirus pandemic: A review	Malekshoar,  M,  Malekshoar, et al	American Journal of Orthodontics and Dentofacial Orthopedics	Review Literature| Revue de littérature
Clinical Characteristics, Diagnosis, and Treatment of Major Coronavirus Outbreaks	Mann,  R,  Perisetti, et al	Frontiers in Medicine	Review Literature| Revue de littérature
Community-Onset Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Young Infants: A Systematic Review	Mark,  EG,  Golden, et al	Journal of Pediatrics	Review Literature| Revue de littérature	SR: performed a systematic review to identify reports published from November 1, 2019, until June 15, 2020, on laboratory-confirmed community-onset SARS-CoV-2 infection in infants younger than 3 months of age. Among young infants with laboratory-confirmed SARS-CoV-2 infection, most cases were mild to moderate and improved with supportive care. Our results demonstrate a need for a high index of suspicion for SARS-CoV-2 infection in young infants presenting with generalized symptoms such as fever or decreased feeding, even in the absence of respiratory symptoms.
The current scenario of COVID-19 outbreak: Bringing world to a halt	Mehrotra,  A,  Sood, et al	Annals of Tropical Medicine and Public Health	Review Literature| Revue de littérature
Mitigating COVID-19 Impact on the Portuguese Population Mental Health: The Opportunity That Lies in Digital Mental Health	Mendes-Santos,  C,  Andersson, et al	Frontiers in Public Health	Review Literature| Revue de littérature
The psychological consequences of the Covid-19 on residents and staff in nursing homes	Mo,  S,  Shi, et al	Work, Aging and Retirement	Review Literature| Revue de littérature
Management of Patients With Glomerulonephritis During the COVID-19 Pandemic: Recommendations From the Canadian Society of Nephrology COVID-19 Rapid Response Team	Moran,  SM,  Barbour, et al	Canadian Journal of Kidney Health and Disease	Review Literature| Revue de littérature
Reopening schools during the COVID-19 pandemic: Overview and rapid systematic review of guidelines and recommendations on preventive measures and the management of cases	Moro,  GL,  Sinigaglia, et al	International Journal of Environmental Research and Public Health	Review Literature| Revue de littérature	Rapid Review: rapid systematic review was conducted through 20 October searching Pubmed, Scopus, and Embase. The recommendations mostly agreed. However, there was no consensus on the criteria for the return to school of students that tested positive, and the flexibility between attendance at school and remote education for high-risk children often varied. School closure was commonly considered as the very last resort for COVID-19 control. Studies are required to evaluate the impact of different recommendations during this autumn term.
Online academics in Pakistan: COVID-19 and beyond	Mumtaz,  N,  Saqulain, et al	Pakistan Journal of Medical Sciences	Review Literature| Revue de littérature
SARS-CoV-2 pandemic impact on traumatic brain injury epidemiology: an overview of the Veneto region	Munari,  M,  De Cassai, et al	Minerva Anestesiol	Review Literature| Revue de littérature
Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases: A cochrane review	Nagraj,  SK,  Eachempati, et al	Dental Cadmos	Review Literature| Revue de littérature
Covid 19 and its implications on dental practice: A review of literature	Naveen Reddy,  R,  Vempalli, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Face mask healthy or unhealthy- A review	Naveenaa,  N,  Rani, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
PMC7683956; Pandemics and pre-existing mental illness: A systematic review and meta-analysis	Neelam,  K,  Duddu, et al	Brain Behav Immun Health	Review Literature| Revue de littérature	SR-MA: systematic search was conducted in the EMBASE, OVID-MEDLINE and PsycINFO databases to identify potentially eligible studies. The review highlights the need for mental health services to address the increased mental health symptoms in people with pre-existing mental illnesses during a pandemic.
The role of respiratory droplet physicochemistry in limiting and promoting the airborne transmission of human coronaviruses: A critical review	Niazi,  S,  Groth, et al	Environmental Pollution	Review Literature| Revue de littérature
Recent Updates on COVID-19 Vaccine Platforms and Its Immunological Aspects: A Review	Nidom,  RV,  Ansori, et al	Systematic Reviews in Pharmacy	Review Literature| Revue de littérature
Covid -19 vs hantavirus- a review	Obuli Ganesh Kishore,  S,  Jothi Priya, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Impact of COVID-19 in ecuador: From inaccurate data to using excess mortality	Ortiz-Prado,  E,  Fernández-Naranjo, et al	Revista Ecuatoriana de Neurologia	Review Literature| Revue de littérature
Technology adoption in education: A systematic literature review	Oyetade,  KE,  Zuva, et al	Advances in Science, Technology and Engineering Systems	Review Literature| Revue de littérature	SR: This research also adds to new literature on COVID-19 in relation to its effect on academic curriculum across the world.
Ards and its underlying pathogenesis in N-COV disease	Padma Priyaa,  N,  Smiline Girija, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Pros and cons on the measures taken by the indian government to curb the menace of Covid 19 - a review	Padmaja,  S,  Smiline Girija, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature
Correlation of Covid-19 With Stomatognathic System With Homeopathic Proposal for Adjunct Treatment to Increase Oral and General Health	Padre,  A,  Mourão, et al	Alternative Therapies in Health and Medicine	Review Literature| Revue de littérature
Challenges and prospects for the conservation of crop genetic resources in field genebanks, in in vitro collections and/or in liquid nitrogen	Panis,  B,  Nagel, et al	Plants	Review Literature| Revue de littérature
PMC7708805; Exploring human-animal host interactions and emergence of COVID-19: evolutionary and ecological dynamics	Perveen,  N,  Bin Muzaffar, et al	Saudi J Biol Sci	Review Literature| Revue de littérature
A Renewed Call for a More Equitable and Holistic Review of Residency Applications in the Era of COVID-19	Pope,  AJ,  Carter, et al	AEM Education and Training	Review Literature| Revue de littérature
Neurological complications of COVID-19 (SARS-CoV-2) literature review	Prado,  EO,  Escobar-Espinosa, et al	Revista Ecuatoriana de Neurologia	Review Literature| Revue de littérature
Mental health consequences of COVID-19 pandemic on adult population: a systematic review	Raihan,  MMH	Mental Health Review Journal	Review Literature| Revue de littérature	SR: PubMed database has been selected randomly from the Google Scholar, Cochrane Library, Embase and PubMed databases. Ten journal articles published between January and July 2020 were selected from the PubMed database for the final review.  There is growing evidence that COVID-19 may be an objective risk factor for mental distress among the general adult population. More psychological and social support should be provided to protect adult people’s mental health.
Epidemiologic trends and characteristics of SARS-CoV-2 infections among children in the United States	Rankin,  DA,  Talj, et al	Curr Opin Pediatr	Review Literature| Revue de littérature
Mental health problems in the general population during and after the first lockdown phase due to the SARS-Cov-2 pandemic: Rapid review of multi-wave studies	Richter,  Dirk,  Riedel-Heller, et al	medRxiv	Review Literature| Revue de littérature	Rapid Review: conducted a rapid review of multi-wave studies in general populations with time points during and after the first lockdown phase. Repeated cross-sectional and longitudinal studies were included. The main outcome assessed was whether indicators of mental health problems have changed during and after the first lockdown phase.
Surgery & COVID-19: A rapid scoping review of the impact of COVID-19 on surgical services during public health emergencies	Rielly,  Connor,  Ng Kamstra, et al	medRxiv	Review Literature| Revue de littérature	ScR: Reorganization of surgical services in response to public health emergencies appears to be context-dependent and has far-reaching consequences that must be better understood in order to optimize future health system responses to public health emergencies.
SARS-CoV-2 seroprevalence worldwide: a systematic review and meta-analysis	Rostami,  A,  Sepidarkish, et al	Clinical Microbiology and Infection	Review Literature| Revue de littérature	SR-MA: systematically reviewed PubMed, Scopus, Embase, medRxiv and bioRxiv databases for preprints or peer-reviewed articles (up to 14 August 2020). Conclusions: This study showed that SARS-CoV-2 seroprevalence varied markedly among geographic regions, as might be expected early in a pandemic. Longitudinal surveys to continually monitor seroprevalence around the globe will be critical to support prevention and control efforts, and might indicate levels of endemic stability or instability in particular countries and regions.
Differences symptoms from covid-19 and common cold: A systematic review	Rusydi,  ET,  Munir, et al	European Journal of Molecular and Clinical Medicine	Review Literature| Revue de littérature	SR
COVID-19; current situation and recommended interventions	Saeed,  H,  Osama, et al	Int J Clin Pract	Review Literature| Revue de littérature
Real-Time Remote Tele-Mentored Echocardiography: A Systematic Review	Salerno,  A,  Kuhn, et al	Medicina (Kaunas)	Review Literature| Revue de littérature	SR:  performed a literature search (PubMed and EMBase) to access articles related to RTMUS echo.
New viral vectors for infectious diseases and cancer	Sasso,  E,  D'Alise, et al	Seminars in immunology	Review Literature| Revue de littérature
Hidden in plain sight: sex and gender in global pandemics	Scully,  EP	Curr Opin HIV AIDS	Review Literature| Revue de littérature
Physical Activity for Improving the Immune System of Older Adults During the COVID-19 Pandemic	Shahrbanian,  S,  Alikhani, et al	Alternative Therapies in Health and Medicine	Review Literature| Revue de littérature
Cardiovascular manifestations of COVID-19: An evidence-based narrative review	Sharma,  YP,  Agstam, et al	Indian J Med Res	Review Literature| Revue de littérature
COVID-19 and Post-intensive Care Syndrome: Community-Based Care for ICU Survivors	Smith,  EMT,  Lee, et al	Home Health Care Management and Practice	Review Literature| Revue de littérature
Diagnostic testing for SARS-CoV-2/COVID19	Spearman,  P	Curr Opin Pediatr	Review Literature| Revue de littérature
Telemedicine for pediatric physiatry: How social distancing can bring physicians and families closer together	Sukhov,  R,  Asante, et al	Journal of pediatric rehabilitation medicine	Review Literature| Revue de littérature
Open defecation and squat toilets, an overlooked risk of fecal transmission of COVID-19 and other pathogens in developing communities	Sun,  S,  Han, et al	Environmental Chemistry Letters	Review Literature| Revue de littérature
Neurological aspects of COVID-19	Tanashyan,  MM,  Kuznetsova, et al	Annals of Clinical and Experimental Neurology	Review Literature| Revue de littérature
Pediatric intrathecal baclofen management during the COVID-19 pandemic in the US and Canada	Thomas,  SP,  Hardesty, et al	Journal of pediatric rehabilitation medicine	Review Literature| Revue de littérature
Rethinking Elective Cataract Surgery Diagnostics, Assessments, and Tools after the COVID-19 Pandemic Experience and Beyond: Insights from the EUROCOVCAT Group	Tognetto,  D,  Brézin, et al	Diagnostics (Basel)	Review Literature| Revue de littérature
Pre-existing Liver Diseases and On-Admission Liver-Related Laboratory Tests in COVID-19: A Prognostic Accuracy Meta-Analysis With Systematic Review	Váncsa,  S,  Hegyi, et al	Frontiers in Medicine	Review Literature| Revue de littérature	SR-MA: searched five databases between 01/01/2020 and 04/23/2020. On-admission platelet count, ALT and AST activities, CRP concentration, and the presence of acute and CLDs predicted the severe course of COVID-19.
Characteristics of clinical trials evaluating cardiovascular therapies for Coronavirus Disease 2019 Registered on ClinicalTrials.gov: a cross sectional analysis	Varshney,  AS,  Wang, et al	American Heart Journal	Review Literature| Revue de littérature
Telemedicine and current clinical practice trends in the COVID-19 pandemic	Wahezi,  SE,  Kohan, et al	Best Practice and Research: Clinical Anaesthesiology	Review Literature| Revue de littérature
Text mining approaches for dealing with the rapidly expanding literature on COVID-19	Wang,  LL,  Lo, et al	Brief Bioinform	Review Literature| Revue de littérature
COVID-19 Antibody Tests: A Valuable Public Health Tool with Limited Relevance to Individuals	West,  R,  Kobokovich, et al	Trends in microbiology	Review Literature| Revue de littérature
Is spironolactone the preferred renin-angiotensin-aldosterone inhibitor for protection against COVID-19?	Wilcox,  CS,  Pitt, et al	J Cardiovasc Pharmacol	Review Literature| Revue de littérature
Magnetic-nanosensor-based virus and pathogen detection strategies before and during covid-19	Wu,  K,  Cheeran, et al	ACS Applied Nano Materials	Review Literature| Revue de littérature
Drug repurposing approach to combating coronavirus: Potential drugs and drug targets	Xu,  J,  Xue, et al	Med Res Rev	Review Literature| Revue de littérature
An economic evaluation of Influenza and COVID -19 pandemic prevention and control interventions: a systematic review	Yigezu,  Amanuel,  Yitayal, et al	Research Square prepub	Review Literature| Revue de littérature	SR: search was done in Pubmed, Web of Science, EMBASE databases, and grey literature for articles published between 1998-2020,
Coronavirus-associated kidney outcomes in COVID-19, SARS, and MERS: a meta-analysis and systematic review	Zhou,  S,  Xu, et al	Renal failure	Review Literature| Revue de littérature	SR-MA:  search of all published studies until 16 June 2020 was performed.Primary kidney involvement is common with coronavirus infection and is associated with significantly increased mortality. The recognition of AKI, CKD, and urgent-start KRT as major risk factors for mortality in coronavirus-infected patients are important steps in reducing future mortality and long-term morbidity in hospitalized patients with coronavirus infection.
A systematic review and future directions of the sharing economy: business models, operational insights and environment-based utilities	Zhu,  X,  Liu, et al	Journal of Cleaner Production	Review Literature| Revue de littérature	SR
A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters	Zhu,  Y,  Bloxham, et al	Clin Infect Dis	Review Literature| Revue de littérature	MA:  To determine the susceptibility of children to household infections the secondary attack rate (SAR) in paediatric household contacts was assessed. The secondary attack rate in paediatric household contacts was lower than in adult household contacts (RR, 0.62; 95% CI, 0.42-0.91).
Pandemic profits: Using CSR to initiatives to help businesses during COVID-19		Strategic Direction	Review Literature| Revue de littérature
Treatment of the novel COVID-19: Why Costa Rica's proposal for the creation of a global pooling mechanism deserves serious consideration?	Abbas,  MZ	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Facilitating Access to Cross-Border Supplies of Patented Pharmaceuticals: The Case of the COVID-19 Pandemic	Abbott,  FM,  Reichman, et al	Journal of International Economic Law	Commentary/Editorial| Commentaire/Éditorial
Methodological approach to ecological researches in the condition of Covid-19	Abdunazarov,  L,  Jobborov, et al	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
Corrigendum to “The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management” [Thromb. Res., 194, October 2020, Pages 101–115] (Thrombosis Research (2020) 194 (101–115), (S0049384820302711), (10.1016/j.thromres.2020.06.029))	Abou-Ismail,  M,  Diamond, et al	Thrombosis research	Commentary/Editorial| Commentaire/Éditorial
Reply to “Antiviral and anti-inflammatory properties of ivermectinand its potential use in Covid-19”	Accinelli,  RA,  Portmann-Baracco, et al	Archivos de Bronconeumologia	Commentary/Editorial| Commentaire/Éditorial
Consumer health information	Adams,  AL	Public Services Quarterly	Commentary/Editorial| Commentaire/Éditorial
Medical Anthropology in the Time of COVID-19	Adams,  V,  Nading, et al	Medical anthropology quarterly	Commentary/Editorial| Commentaire/Éditorial
The COVID-19 Economic Crisis	Adams-Prassl,  A,  Cloyne, et al	Fiscal Studies	Commentary/Editorial| Commentaire/Éditorial
Impact of covid-19 pandemic on renal care services in Nigeria	Adejumo,  OA	Pan African Medical Journal	Commentary/Editorial| Commentaire/Éditorial
How the COVID-19 response is altering the legal and regulatory landscape on abortion	Ahmed,  A	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
The Impact of the COVID-19 Pandemic on the Mental Health of the Rickshaw-Puller in Bangladesh	Ahmed,  F,  Sifat, et al	Journal of Loss and Trauma	Commentary/Editorial| Commentaire/Éditorial
COVID-19 in Bangladesh: How the Awami league transformed a crisis into a disaster	Ahmed,  I	Asia-Pasific Journal: Japan Focus	Commentary/Editorial| Commentaire/Éditorial
Blood Cell Anomalies in COVID-19	Ahnach,  M	Turk J Haematol	Commentary/Editorial| Commentaire/Éditorial
Basic science and clinical studies on non-covid-19 topics, of coronavirus victims	Akhondzadeh,  S,  Shamabadi, et al	Avicenna Journal of Medical Biotechnology	Commentary/Editorial| Commentaire/Éditorial
Is the Coronavirus crisis a Teacher for the Future? Italian experiences in the frame of worldwide discourses	Aliberti,  SM,  De Caro, et al	Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen	Commentary/Editorial| Commentaire/Éditorial
Gynecological cancers and the global COVID-19 pandemic	Alkatout,  I,  Karimi-Zarchi, et al	J Turk Ger Gynecol Assoc	Commentary/Editorial| Commentaire/Éditorial
The state of alert for the covid-19 crisis and the effect on regional self-government	Alonso,  GMI	Revista Catalana de Dret Public	Commentary/Editorial| Commentaire/Éditorial
Science, technology and innovation policies looking backwards, forwards and beyond: Developmental challenges and opportunities for ibero-america in the era of covid-19	Álvarez,  I,  Natera, et al	Revista de Economia Mundial	Commentary/Editorial| Commentaire/Éditorial
Visitor management in world heritage destinations before and after covid-19, angkor	Alvarez-Sousa,  A,  Prados, et al	Sustainability (Switzerland)	Commentary/Editorial| Commentaire/Éditorial
Answer set programming in healthcare: Extended overview	Alviano,  M,  Bertolucci, et al		Commentary/Editorial| Commentaire/Éditorial
Implications of covid-19 for the management of chronic non-communicable diseases in sub-Saharan Africa: Application of the chronic care model	Amu,  H,  Dowou, et al	Pan African Medical Journal	Commentary/Editorial| Commentaire/Éditorial
Challenges of the COVID-19 pandemic for child and adolescent mental health: Promoting psychosocial and positive well-being	Anbarasu,  A,  Bhuvaneswari, et al	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
Special issue: Fire, flood, pestilence and protest introduction	Anderson,  N	Derrida Today	Commentary/Editorial| Commentaire/Éditorial
Domestic violence and Japan’s covid-19 pandemic	Ando,  R	Asia-Pasific Journal: Japan Focus	Commentary/Editorial| Commentaire/Éditorial
Arteritis and Large Vessel Occlusive Strokes in Children Following COVID-19 Infection	Appavu,  B,  Deng, et al	Pediatrics	Commentary/Editorial| Commentaire/Éditorial
Occupational team safety in ECT practice during the COVID-19 pandemic	Araujo,  RF,  Quites, et al	Brazilian Journal of Anesthesiology	Commentary/Editorial| Commentaire/Éditorial
Epidemic spreading: Tailored models for COVID-19	Arenas,  A,  Gómez-Gardeñes, et al	Europhysics News	Commentary/Editorial| Commentaire/Éditorial
Working from Home and COVID-19: The Chances and Risks for Gender Gaps	Arntz,  M,  Ben Yahmed, et al	Intereconomics	Commentary/Editorial| Commentaire/Éditorial
Use of a Modified Plastic Viewing System for Safer General Anesthesia Care in Pediatric Ophthalmic Surgery During the COVID-19 Pandemic	Ashkenazy,  N,  Orihuela, et al	Ophthalmic surgery, lasers & imaging retina	Commentary/Editorial| Commentaire/Éditorial
Using traditional methods of making Uzbek costume in modern design during quarantine due to COVID-19	Atakhanova,  FZ	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
Promoting research in medical students during the covid-19 pandemic: School of young researchers	Aveiro-Róbalo,  TR,  Garlisi-Torales, et al	Educacion Medica	Commentary/Editorial| Commentaire/Éditorial
COVID-19: Lessons from a construction site, can we apply one industry safety protocol to another?	Avice,  T	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
Ten questions concerning occupant health in buildings during normal operations and extreme events including the COVID-19 pandemic	Awada,  M,  Becerik-Gerber, et al	Building and Environment	Commentary/Editorial| Commentaire/Éditorial
Face mask exemptions, psychiatric patients, and COVID-19	Ayuso,  JL,  Soriano, et al	Eur Psychiatry	Commentary/Editorial| Commentaire/Éditorial
Indonesian government dilematics in Covid-19 pandemic handling	Azikin,  A,  Karno, et al	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
A call to strengthen data in response to COVID-19 and beyond	Azzopardi-Muscat,  N,  Kluge, et al	J Am Med Inform Assoc	Commentary/Editorial| Commentaire/Éditorial
Three questions on COVID-19: testing, infectiousness, and school opening	Bachelet,  VC	Medwave	Commentary/Editorial| Commentaire/Éditorial
Women at the Frontline of COVID-19: Can Gender Mainstreaming in Free Trade Agreements Help?	Bahri,  A	Journal of International Economic Law	Commentary/Editorial| Commentaire/Éditorial
Deleterious Outcomes in Long-Hauler COVID-19: The Effects of SARS-CoV-2 on the CNS in Chronic COVID Syndrome	Baig,  AM	ACS Chem Neurosci	Commentary/Editorial| Commentaire/Éditorial
Religion in the age of social distancing: How COVID-19 presents new directions for research	Baker,  JO,  Martí, et al	Sociology of Religion: A Quarterly Review	Commentary/Editorial| Commentaire/Éditorial
The Mental Health Effects of the First Two Months of Lockdown during the COVID-19 Pandemic in the UK*	Banks,  J,  Xu, et al	Fiscal Studies	Commentary/Editorial| Commentaire/Éditorial
To Curb the Impact of COVID-19 on the Provision of Cancer Care, What Role Will Rapid Antigen Testing Play?	Barnes,  O	Clinical oncology	Commentary/Editorial| Commentaire/Éditorial
COVID-19: a catalyst to transform our future?	Baybutt,  M,  Dooris, et al	International Journal of Health Promotion and Education	Commentary/Editorial| Commentaire/Éditorial
Joining science and experience to combat the effects of COVID-19	Bélanger,  SAH,  Pedlar, et al	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
Navigating Early Careers in Heart Failure in the Era of Novel Coronavirus Disease-2019	Bellam,  N,  Denfeld, et al	Journal of cardiac failure	Commentary/Editorial| Commentaire/Éditorial
COVID-19 calls for virtue ethics	Bellazzi,  F,  Boyneburgk, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Inpatient Hyperglycemia Management and COVID-19	Bellido,  V,  Pérez, et al	Diabetes Ther	Commentary/Editorial| Commentaire/Éditorial
The impact of the COVID-19 pandemic on children with autism spectrum disorders	Bellomo,  TR,  Prasad, et al	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
Covid-19 and impairment of spermatogenesis: What if fever was the only cause?	Bendayan,  M,  Boitrelle, et al	EClinicalMedicine	Commentary/Editorial| Commentaire/Éditorial
Prioritizing care for severe asthma during SARS-CoV-2 pandemic	Benfante,  A,  Scichilone, et al	Pulmonology	Commentary/Editorial| Commentaire/Éditorial
The critical distinction between characterisation and causation in studies of COVID-19-associated cerebrovascular pathology	Benger,  M,  Williams, et al	Brain, behavior, and immunity	Commentary/Editorial| Commentaire/Éditorial
Covid-19, the outlook for corporations, and the changing demographic landscape: An interview with chiqui cartagena	Beniflah,  J,  Cartagena, et al	Journal of Cultural Marketing Strategy	Commentary/Editorial| Commentaire/Éditorial
Housing at the frontline of the COVID-19 challenge: A commentary on “Rising home values and Covid-19 case rates in Massachusetts”	Bentley,  R,  Baker, et al	Social Science and Medicine	Commentary/Editorial| Commentaire/Éditorial
PMC7708894; "Neurological manifestations of COVID-19" - guideline of the German society of neurology	Berlit,  P,  Bösel, et al	Neurol Res Pract	Commentary/Editorial| Commentaire/Éditorial
Paying Another Tribute to the COVID-19 Pandemic: The Decrease of Early Lung Cancers	Bertolaccini,  L,  Sedda, et al	Ann Thorac Surg	Commentary/Editorial| Commentaire/Éditorial
The Economics of Lockdown	Besley,  T,  Stern, et al	Fiscal Studies	Commentary/Editorial| Commentaire/Éditorial
How has the COVID-19 pandemic changed patient care and the practice of medical physics in an academic environment?	Beth Allen,  M,  Wang, et al	Journal of Applied Clinical Medical Physics	Commentary/Editorial| Commentaire/Éditorial
To be or not to be? A missional and practical theological perspective on being church without walls amidst coronavirus disease 2019: A challenge or an opportunity?	Beukes,  JW	HTS Teologiese Studies / Theological Studies	Commentary/Editorial| Commentaire/Éditorial
Who may heal? A plea from traditional healers to participate in treating covid-19	Beyers,  J	HTS Teologiese Studies / Theological Studies	Commentary/Editorial| Commentaire/Éditorial
Oral lesions in COVID-19 infection: Is long-term follow-up important in the affected patients?	Bezerra,  TM,  Feitosa, et al	Oral diseases	Commentary/Editorial| Commentaire/Éditorial
Monetization matters: Active tail risk management and the great virus crisis	Bhansali,  V,  Chang, et al	Journal of Portfolio Management	Commentary/Editorial| Commentaire/Éditorial
A Rapid Primary Healthcare Response to COVID-19: An Equity-Based and Systems-Thinking Approach to Care Ensuring that No One Is Left Behind	Bhatti,  S,  Commisso, et al	Healthcare quarterly (Toronto, Ont.)	Commentary/Editorial| Commentaire/Éditorial
Reactivated world war two traumatic memories in COVID-19 lockdown period	Bigarré,  I,  Landon, et al	Clinical Case Reports	Commentary/Editorial| Commentaire/Éditorial
Israel National Obstetric Anesthesia WhatsApp group as a communication tool, before and during the COVID-19 pandemic	Binyamin,  Y,  Weiniger, et al	International Journal of Obstetric Anesthesia	Commentary/Editorial| Commentaire/Éditorial
Donating convalescent plasma for COVID-19 patients	Black,  E	British dental journal	Commentary/Editorial| Commentaire/Éditorial
The responses of the European union to certain avatars in the XXI century that determine the process of its formation	Blanco,  SM,  Díaz Barrado, et al	Araucaria	Commentary/Editorial| Commentaire/Éditorial
Socio-economic factors on the evolution of mortality in Europe in the XXI century: Policy proposals to face the COVID-19 crisis	Blanco-Arana,  M	Revista de Economia Mundial	Commentary/Editorial| Commentaire/Éditorial
Medication and substance use increases among people using cannabis medically during the COVID-19 pandemic	Boehnke,  KF,  McAfee, et al	International Journal of Drug Policy	Commentary/Editorial| Commentaire/Éditorial
PMC7716114; Correction to: Effect of PEEP decremental on respiratory mechanics, gas exchange, pulmonary regional ventilation, and hemodynamics in patients with SARS-Cov-2-associated Acute Respiratory Distress Syndrome	Bonny,  V,  Janiak, et al	Crit Care	Commentary/Editorial| Commentaire/Éditorial
The coronavirus crisis: Disability politics and activism in contemporary Japan	Bookman,  M	Asia-Pasific Journal: Japan Focus	Commentary/Editorial| Commentaire/Éditorial
Guillain-Barré Syndrome Associated with SARS-CoV-2	Botello-Hernandez,  E,  Castillo-González, et al	Revista Ecuatoriana de Neurologia	Commentary/Editorial| Commentaire/Éditorial
Check for COVID-19 updates on home isolation and work notes	Bracamonte,  J,  Chavez, et al	Family practice management	Commentary/Editorial| Commentaire/Éditorial
Harnessing the Power of Networks of Care for Universal Health Coverage	Brady,  E,  Carmone, et al	Health Systems and Reform	Commentary/Editorial| Commentaire/Éditorial
Tobacco and e-cigarette shops awarded 'essential business' labels in France during COVID-19	Braillon,  A	Tobacco Induced Diseases	Commentary/Editorial| Commentaire/Éditorial
Robotic urological surgery in the time of COVID-19: Challenges and solutions	Branche,  B,  Carbonara, et al	Urology Practice	Commentary/Editorial| Commentaire/Éditorial
Is NHS Test and Trace exacerbating COVID-19 inequalities?	Briggs,  AdamDM,  Fraser, et al	The Lancet	Commentary/Editorial| Commentaire/Éditorial
When the wrong people are immune	Brown,  TR	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Decision-making on the labour ward during the COVID-19 pandemic	Bruce-Hickman,  K,  Fan, et al	International Journal of Obstetric Anesthesia	Commentary/Editorial| Commentaire/Éditorial
The covid-19 pandemic’s effects on freedom of movement and the penalty system under the state of alert	Cabré,  API	Revista Catalana de Dret Public	Commentary/Editorial| Commentaire/Éditorial
“Essential” services, risk, and child protection in the time of COVID-19: An opportunity to prioritize chronic need	Caldwell,  J,  Delaye, et al	Developmental Child Welfare	Commentary/Editorial| Commentaire/Éditorial
Colloquy with Steven Van de Walle on trust in Public Administration	Canel,  MJ	Church, Communication and Culture	Commentary/Editorial| Commentaire/Éditorial
Characterising non-melanoma skin cancer undergoing surgical management during the COVID-19 pandemic	Capitelli-McMahon,  H,  Hurley, et al	Journal of Plastic, Reconstructive and Aesthetic Surgery	Commentary/Editorial| Commentaire/Éditorial
Covid-19 and medical liability: Challenges of an unknown disease that became a pandemic	Cárdenas Villarreal,  H,  Pérez Saavedra, et al	Acta Bioethica	Commentary/Editorial| Commentaire/Éditorial
So what? Hong Kong’s COVID-19 success won’t be why it remembers 2020	Cartledge,  S	Asia-Pasific Journal: Japan Focus	Commentary/Editorial| Commentaire/Éditorial
Correction to: Chest CT for early detection and management of coronavirus disease (COVID-19): a report of 314 patients admitted to Emergency Department with suspected pneumonia	Cartocci,  G,  Colaiacomo, et al	Radiol Med	Commentary/Editorial| Commentaire/Éditorial
Physiotherapy in the COVID-19 health crisis: What if I am not sick with COVID-19?	Casal-Beloy,  I,  Casal-Beloy, et al	Fisioterapia	Commentary/Editorial| Commentaire/Éditorial
Coronavirus disease 2019 and stroke: how to avoid a new lockdown for stroke patients	Caso,  V	Curr Opin Neurol	Commentary/Editorial| Commentaire/Éditorial
Significant impact of COVID-19 on organ donation and transplantation in a low-prevalence country: Australia	Chadban,  SJ,  McDonald, et al	Kidney international	Commentary/Editorial| Commentaire/Éditorial
The “living dead” within “death-worlds”: Gender crisis and covid-19 in India	Chakraborty,  D	Gender, Work and Organization	Commentary/Editorial| Commentaire/Éditorial
An exegesis of the parable of the good samaritan (Lk 10:25–35) and its relevance to the challenges caused by covid-19	Chamburuka,  PM,  Gusha, et al	HTS Teologiese Studies / Theological Studies	Commentary/Editorial| Commentaire/Éditorial
Correction to: the Post-Pandemic World: between Constitutionalized and Authoritarian Orders – China’s Narrative-Power Play in the Pandemic Era (Journal of Chinese Political Science, (2020), 10.1007/s11366-020-09695-3)	Chang,  YY	Journal of Chinese Political Science	Commentary/Editorial| Commentaire/Éditorial
Virtual consultations: delivering outpatient clinics in paediatric surgery during the COVID-19 pandemic	Charnell,  AM,  Hannon, et al	Annals of Pediatric Surgery	Commentary/Editorial| Commentaire/Éditorial
TRANSFORMATION WITH TRUSTWORTHY DIGITAL: POLICY DESIDERATA FOR BUSINESSES IN POST COVID-19 WORLD	Chaudhuri,  A	EDPACS	Commentary/Editorial| Commentaire/Éditorial
Management and outcomes of mammalian bite injuries during COVID-19 and implications for future practice	Chicco,  M,  Torres-Grau, et al	Journal of Plastic, Reconstructive and Aesthetic Surgery	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and Tinnitus	Chirakkal,  P,  Hail, et al	Ear Nose Throat J	Commentary/Editorial| Commentaire/Éditorial
Issues of digital trade rules and implications for korea in the post COVID-19 world	Cho,  J,  Ahn, et al	Journal of International Logistics and Trade	Commentary/Editorial| Commentaire/Éditorial
Hydroxychloroquine for the treatment of covid-19: The importance of scrutiny of positive trials	Chow,  R,  Simone, et al	Annals of Palliative Medicine	Commentary/Editorial| Commentaire/Éditorial
Prevention and control of patients in surgical wards of local hospitals facing COVID-19	Chuang,  Y,  Jisheng, et al	Asian Journal of Surgery	Commentary/Editorial| Commentaire/Éditorial
Erratum: Testing in the Time of COVID-19: A Sudden Transition to Unproctored Online Exams (J. Chem. Educ. (2020) 97: 9 (3413-3417) DOI: 10.1021/acs.jchemed.0c00546)	Clark,  TM,  Callam, et al	Journal of chemical education	Commentary/Editorial| Commentaire/Éditorial
Migration ethics in pandemic times	Collins,  FL	Dialogues in Human Geography	Commentary/Editorial| Commentaire/Éditorial
National tourism strategies during the Covid-19 pandemic	Collins-Kreiner,  N,  Ram, et al	Annals of Tourism Research	Commentary/Editorial| Commentaire/Éditorial
A virus tests the welfare state	Conrad,  C	Geschichte und Gesellschaft	Commentary/Editorial| Commentaire/Éditorial
Neurological and psychological effects of COVID-19 in children and adolescents	Cortés,  ME	Revista Ecuatoriana de Neurologia	Commentary/Editorial| Commentaire/Éditorial
Neurological manifestations and COVID-19	Costa,  A,  Silva-Pinto, et al	Acta Medica Portuguesa	Commentary/Editorial| Commentaire/Éditorial
Increasing ICU beds in the country during the COVID-19 pandemic: Inequalities between public vs. private and regional inequities	Cotrim Junior,  DF,  Cabral, et al	Physis	Commentary/Editorial| Commentaire/Éditorial
Co-infection, SARS-CoV-2 and influenza: an evolving puzzle	Covin,  S,  Rutherford, et al	Clin Infect Dis	Commentary/Editorial| Commentaire/Éditorial
The impact of the COVID-19 pandemic on the mental health and well-being of children and young people	Cowie,  H,  Myers, et al	Children and Society	Commentary/Editorial| Commentaire/Éditorial
What Happened to Person-Centered Care? Observations During the COVID-19 Pandemic	Crogan,  N	Journal for Nurse Practitioners	Commentary/Editorial| Commentaire/Éditorial
Scoping review protocol: the use of telemedicine in providing opioid agonist treatment and related psychosocial supports	Crowley,  D,  Homeniuk, et al	BMJ Open	Commentary/Editorial| Commentaire/Éditorial
From chose time to the ends of sleep: Labor time and basic income in late capitalism	da Silva,  JP	Sociedade e Estado	Commentary/Editorial| Commentaire/Éditorial
A proposal of a “ready to use” COVID-19 control strategy in an Oncology ward: Utopia or reality?	Dalu,  D,  Rota, et al	Critical reviews in oncology/hematology	Commentary/Editorial| Commentaire/Éditorial
Critical considerations for hepatopanceratobilliary surgeries during covid-19 pandemic	Dashti,  H,  Moghadam, et al	Hepatitis Monthly	Commentary/Editorial| Commentaire/Éditorial
PMC7717394; USA stockpiling of remdesivir: How should the world respond?	Dawoud,  D,  Chalkidou, et al	J Comp Eff Res	Commentary/Editorial| Commentaire/Éditorial
Commentary on “Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy” by D.C. Mastellos et al	de Miranda Santos,  IKF,  de Barros Cardoso, et al	Clinical Immunology	Commentary/Editorial| Commentaire/Éditorial
Clinical characteristics of COVID-19 patients and the main nursing diagnoses	de Souza,  LP,  Vasconcellos, et al	Scientia Medica	Commentary/Editorial| Commentaire/Éditorial
The importance of medical devices in preventing and combating SARS-CoV-2 and cooperation between national regulators, academy and industry - Perspectives from the Portuguese reality	De-Abreu,  I	Biomedical and Biopharmaceutical Research	Commentary/Editorial| Commentaire/Éditorial
Covid-19, single-sourced diagnostic tests, and innovation policy	Deb,  C,  Moneer, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Response to the Coronavirus Disease 2019 Pandemic by the Spine Division at a Level-I Academic Referral Center	DeKeyser,  GJ,  Brodke, et al	J Am Acad Orthop Surg	Commentary/Editorial| Commentaire/Éditorial
Electroencephalography at the time of COVID-19	Del Brutto,  OH	Revista Ecuatoriana de Neurologia	Commentary/Editorial| Commentaire/Éditorial
The contribution of international organizations, in particular of the European union, to the fight against global health threats: COVID-19 and its challenges and opportunities	Delfino,  F	Araucaria	Commentary/Editorial| Commentaire/Éditorial
Check for covid-19 updates on home isolation and work notes	Dera,  JD	Family practice management	Commentary/Editorial| Commentaire/Éditorial
Transitioning ambulatory care pharmacy services to telemedicine while maintaining multidisciplinary collaborations	DeRemer,  CE,  Reiter, et al	Am J Health Syst Pharm	Commentary/Editorial| Commentaire/Éditorial
Association of skin diseases, biological treatment and COVID-19 during the first wave of the pandemic	Descalzo,  MA,  Garcia-Doval, et al	Br J Dermatol	Commentary/Editorial| Commentaire/Éditorial
Low bioavailability hinders drug discovery against COVID-19, guided by in silico docking	Dey,  P	Br J Pharmacol	Commentary/Editorial| Commentaire/Éditorial
Effect of perceived stress on psychological well-being of health care workers during COVID 19: Mediating role of subjective happiness	Dhingra,  V,  Dhingra, et al	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
Covid-19 and Flattening the Curve: a Feedback Control Perspective	Di Lauro,  F,  Kiss, et al	IEEE Control Systems Letters	Commentary/Editorial| Commentaire/Éditorial
The “Total Continuous War” and the COVID-19 Pandemic: Neoliberal Governmentality, Disposable Bodies and Protected Lives	Dias,  BLCV,  Deluchey, et al	Law, Culture and the Humanities	Commentary/Editorial| Commentaire/Éditorial
Is there an underlying link between COVID-19, ACE2, oxytocin and vitamin D?	Diep,  PT	Medical hypotheses	Commentary/Editorial| Commentaire/Éditorial
Gender-Based Violence, Twin Pandemic to COVID-19	Dlamini,  J	Critical Sociology	Commentary/Editorial| Commentaire/Éditorial
Research ethics in a pandemic: Considerations for the use of research infrastructure and resources for public health activities	Doerr,  M,  Wagner, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Glucose or Insulin, Which Is the Culprit in Patients with COVID-19 and Diabetes?	Donath,  MY	Cell Metabolism	Commentary/Editorial| Commentaire/Éditorial
Can the COVID-19 interstate travel restrictions help lift the FDA's blood ban?	Dorfman,  D	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Ensuring the integrity of transportation and logistics during the COVID-19 pandemic	Dorofeev,  A,  Kurganov, et al		Commentary/Editorial| Commentaire/Éditorial
Determining the infectious potential of individuals with positive RT-PCR SARS-CoV-2 tests	Doshi,  P,  Powers, et al	Clin Infect Dis	Commentary/Editorial| Commentaire/Éditorial
Social Distancing Requirements and the Determinants of the COVID-19 Recession and Recovery in Europe	Dreger,  C,  Gros, et al	Intereconomics	Commentary/Editorial| Commentaire/Éditorial
The place of China in the global value chains – current situation and future trends	Drelich-Skulska,  B,  Jankowiak, et al	Transformations in Business and Economics	Commentary/Editorial| Commentaire/Éditorial
The limits of solidarity. Technologies of government in times of corona	Drotbohm,  H,  Reichardt, et al	Geschichte und Gesellschaft	Commentary/Editorial| Commentaire/Éditorial
Correction: COVID-19 Contact Tracing Apps: A Technologic Tower of Babel and the Gap for International Pandemic Control	Du,  L,  Raposo, et al	JMIR Mhealth Uhealth	Commentary/Editorial| Commentaire/Éditorial
Any and every cure for covid-19: An imminent epidemic of alternative remedies amidst the pandemic?	Eboreime,  EA,  Iwu, et al	Pan African Medical Journal	Commentary/Editorial| Commentaire/Éditorial
8th Joint americas and european committees for treatment and research in multiple sclerosis (ACTRIMS-ECTRIMS) Meeting (MSVirtual2020)	Egan-Auderset,  M	Drugs of the Future	Commentary/Editorial| Commentaire/Éditorial
Individualism, Polarization and Recovery from the COVID-19 Crisis	Eichengreen,  B	Intereconomics	Commentary/Editorial| Commentaire/Éditorial
Manoeuvring Through the Crisis: Labour Market and Social Policies During the COVID-19 Pandemic	Eichhorst,  W,  Marx, et al	Intereconomics	Commentary/Editorial| Commentaire/Éditorial
Writing multi-vocal intersectionality in times of crisis	Einola,  K,  Elkina, et al	Gender, Work and Organization	Commentary/Editorial| Commentaire/Éditorial
COVID-19 cutaneous manifestations: simplifying the confusion	el-Azhary,  R	International journal of dermatology	Commentary/Editorial| Commentaire/Éditorial
Coronavirus Disease-2019 and dental practice: A project on the use of ozonized water in the water circuit of the dental armchair	Elena,  B,  Francesca, et al	Stomatologija	Commentary/Editorial| Commentaire/Éditorial
CAF health protection during pandemic disease events: 1918 and 2020	Engen,  RC	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
Erratum: BCG vaccine protection from severe coronavirus disease 2019 (COVID-19) (Proc. Natl. Acad. Sci. (2020) 117 (17720-17726) DOI: 10.1073/pnas.2008410117)	Escobar,  LE,  Molina-Cruz, et al	Proceedings of the National Academy of Sciences of the United States of America	Commentary/Editorial| Commentaire/Éditorial
The church and the indispensability and fragility of morality revealed by the covid-19 pandemic	Etienne de Villiers,  D	HTS Teologiese Studies / Theological Studies	Commentary/Editorial| Commentaire/Éditorial
Does MAFLD really increase the severity of COVID-19?	Fajar,  JK,  Wibowo, et al	Digestive and Liver Disease	Commentary/Editorial| Commentaire/Éditorial
B careful: Humoral responses and COVID-19 severity	Fanous,  H,  Guerrero-Pena, et al	Sci Immunol	Commentary/Editorial| Commentaire/Éditorial
Social enterprise crowdfunding in an acute crisis	Farhoud,  M,  Shah, et al	Journal of Business Venturing Insights	Commentary/Editorial| Commentaire/Éditorial
The COVID-19 pandemic: A time for veterinary leadership in one health	Fathke,  RL,  Rao, et al	One Health	Commentary/Editorial| Commentaire/Éditorial
The COVID-19 and Influenza “Twindemic”: Barriers to Influenza Vaccination and Potential Acceptance of SARS-CoV2 Vaccination in African Americans	Ferdinand,  KC,  Nedunchezhian, et al	Journal of the National Medical Association	Commentary/Editorial| Commentaire/Éditorial
Regulatory flexibility for COVID-19 research	Fernandez Lynch,  H,  Dickert, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
3D printing novel PPE for response to covid-19 related shortages	Fields,  BKK,  Demirjian, et al		Commentary/Editorial| Commentaire/Éditorial
Pandemic ponderings on the limited lens of our age stereotyping research: Considering privilege and racism	Finkelstein,  LM	Work, Aging and Retirement	Commentary/Editorial| Commentaire/Éditorial
Is Guillain Barre syndrome truly caused by SARS-CoV-2?	Finsterer,  J,  Scorza, et al	American Journal of Emergency Medicine	Commentary/Editorial| Commentaire/Éditorial
Re-imagining play spaces in early childhood education: Supporting girls’ motive orientation to STEM in times of COVID-19	Fleer,  M	Journal of Early Childhood Research	Commentary/Editorial| Commentaire/Éditorial
The art of the possible in approaching efficacy trials for COVID19 convalescent plasma	Focosi,  D,  Farrugia, et al	International Journal of Infectious Diseases	Commentary/Editorial| Commentaire/Éditorial
Pandemic tourism: the new era of catering sector after Covid-19	Fonseca,  C,  Jorge, et al	Anatolia	Commentary/Editorial| Commentaire/Éditorial
Resilience and response of the congenital cardiac network in Italy during the COVID-19 pandemic	Formigari,  R,  Marcora, et al	J Cardiovasc Med (Hagerstown)	Commentary/Editorial| Commentaire/Éditorial
Participation in an existing massive open online course in dentistry during the COVID-19 pandemic	France,  K,  Hangorsky, et al	Journal of dental education	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and the pillars of information ‐ the data deluge column	Frederick,  DE	Library Hi Tech News	Commentary/Editorial| Commentaire/Éditorial
Communication: A safe skin cancer surgery set-up during the COVID-19 crisis	Friebel,  TR,  Rinkoff, et al	Journal of Plastic, Reconstructive and Aesthetic Surgery	Commentary/Editorial| Commentaire/Éditorial
Virology and biopolitics	Fritsch,  M	Derrida Today	Commentary/Editorial| Commentaire/Éditorial
Mass culling of minks to protect the COVID-19 vaccines: is it rational?	Frutos,  R,  Devaux, et al	New Microbes and New Infections	Commentary/Editorial| Commentaire/Éditorial
Home rehabilitation in patients with COVID-19	Frutos-Reoyo,  E,  Cantalapiedra-Puentes, et al	Rehabilitacion	Commentary/Editorial| Commentaire/Éditorial
“Quick and dirty”: Intuitive cognitive style predicts trust in Didier Raoult and his hydroxychloroquine-based treatment against COVID-19	Fuhrer,  J,  Cova, et al	Judgment and Decision Making	Commentary/Editorial| Commentaire/Éditorial
Mycoplasma pneumoniae pneumonia and respiratory syncytial virus infection in Japan during the severe acute respiratory syndrome coronavirus 2 pandemic	Fujita,  J	Respir Investig	Commentary/Editorial| Commentaire/Éditorial
CORONAVIRUS: Factors determining SARS-CoV-2 endemicity	Funk,  M	Science	Commentary/Editorial| Commentaire/Éditorial
Which app is right for my CVD patient?	Gabizon,  I,  Bhagirath, et al	Heart and Metabolism	Commentary/Editorial| Commentaire/Éditorial
Legal and ethical implications of wastewater monitoring of SARS-CoV-2 for COVID-19 surveillance	Gable,  L,  Ram, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
TRIBULACIONES DE LA INVESTIGACIÓN EN TIEMPOS DE COVID-19	Gaitán Duarte,  H	Revista colombiana de obstetricia y ginecologia	Commentary/Editorial| Commentaire/Éditorial
Lies in the time of COVID	Gaon,  S	Derrida Today	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and its effects on the asymmetry of the EU-China relations: Towards a new economic paradigm?	García-Weil,  A	Araucaria	Commentary/Editorial| Commentaire/Éditorial
Cyclin dependent kinase inhibitors as a new potential therapeutic option in management of COVID-19	Gargouri,  M,  Alzwi, et al	Medical hypotheses	Commentary/Editorial| Commentaire/Éditorial
PMC7716792; COVID-19 and ARDS: the baby lung size matters	Gattinoni,  L,  Busana, et al	Intensive Care Med	Commentary/Editorial| Commentaire/Éditorial
Anticipating the impacts of the COVID-19 pandemic on wildlife	Gaynor,  KM,  Brashares, et al	Frontiers in Ecology and the Environment	Commentary/Editorial| Commentaire/Éditorial
The EU’s Pandemic Response: Tackling COVID-19, Building the Future	Gentiloni,  P	Intereconomics	Commentary/Editorial| Commentaire/Éditorial
Impact on routine immunization services during the lockdown period in India: Implications and future recommendations	Ghatak,  N,  Marzo, et al	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
Disability and the COVID-19 Pandemic: Using Twitter to Understand Accessibility during Rapid Societal Transition	Gleason,  C,  Valencia, et al		Commentary/Editorial| Commentaire/Éditorial
Distance teaching and teaching 'as' distance. a critical reading of online teaching instruments during and after the pandemic	Gobbi,  A,  Rovea, et al	Teoria de la Educacion	Commentary/Editorial| Commentaire/Éditorial
Food Insecurity and Collateral Consequences of Punishment Amidst the COVID-19 Pandemic	Golembeski,  CA,  Irfan, et al	World Medical and Health Policy	Commentary/Editorial| Commentaire/Éditorial
Centering community in COVID-19 responses: refugee women's livelihoods in a global pandemic	Golesorkhi,  LZ,  Fortson, et al	International Journal of Sociology and Social Policy	Commentary/Editorial| Commentaire/Éditorial
COVID-19 highlights the need for servicer access to a government-backed liquidity facility	Goodman,  LS,  Kaul, et al	Journal of Structured Finance	Commentary/Editorial| Commentaire/Éditorial
Fundamental rights under Covid-19: an European perspective on videoconferencing in court	Gori,  P,  Pahladsingh, et al	ERA Forum	Commentary/Editorial| Commentaire/Éditorial
SOBERANA, Cuba's COVID-19 vaccine candidates: Dagmar garcía-rivera PhD	Gorry,  C	MEDICC Review	Commentary/Editorial| Commentaire/Éditorial
Validation of CDC 3-Level Risk Classification for Healthcare Workers Exposed to COVID-19	Gragnani,  CM,  Fernandes, et al	Infect Control Hosp Epidemiol	Commentary/Editorial| Commentaire/Éditorial
State and local government employment in the COVID-19 crisis	Green,  D,  Loualiche, et al	Journal of Public Economics	Commentary/Editorial| Commentaire/Éditorial
Nordic welfare states—still standing or changed by the COVID-19 crisis?	Greve,  B,  Blomquist, et al	Social Policy and Administration	Commentary/Editorial| Commentaire/Éditorial
Immunising birthsex: Ontology’s place in the pandemic	Griffin,  C	Derrida Today	Commentary/Editorial| Commentaire/Éditorial
Covid-19: Air travellers should not be considered high risk, says European guidance	Griffin,  S	Bmj	Commentary/Editorial| Commentaire/Éditorial
Guideline for the management of hip fractures 2020: Guideline by the Association of Anaesthetists	Griffiths,  R,  Babu, et al	Anaesthesia	Commentary/Editorial| Commentaire/Éditorial
Prostate Ultrahypofractionation – Rising to Challenges Presents Opportunities in the COVID-19 Era	Griffiths,  W,  Frew, et al	Clinical oncology	Commentary/Editorial| Commentaire/Éditorial
The impact of Covid-19 on sport	Grix,  J,  Brannagan, et al	International Journal of Sport Policy and Politics	Commentary/Editorial| Commentaire/Éditorial
Uncertainty in aging and lifespan research: Covid-19 as catalyst for addressing the elephant in the room	Grote,  G,  Pfrombeck, et al	Work, Aging and Retirement	Commentary/Editorial| Commentaire/Éditorial
The intention to be vaccinated against COVID-19: stated preferences before vaccines were available	Grüner,  S,  Krüger, et al	Applied Economics Letters	Commentary/Editorial| Commentaire/Éditorial
Canadian public health agency lessons on using choropleth maps to characterize geographic distribution of COVID-19 data	Guillette,  D,  Stratton, et al	Acta Medica Portuguesa	Commentary/Editorial| Commentaire/Éditorial
Applying the proportionality principle to COVID-19 antibody testing	Gunnarsdóttir,  HD,  Sinha, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Negative results in nucleic acid test of covid-19 patients: Assessment from the perspective of clinical laboratories	Guo,  W,  Zhou, et al	Annals of Palliative Medicine	Commentary/Editorial| Commentaire/Éditorial
Role of homoeopathy in management of COVID-19 complications	Gupta,  G,  Vyas, et al	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
Medikamente gegen COVID-19 (Stand Ende März 2020)	Gysling,  E	Pharma-Kritik	Commentary/Editorial| Commentaire/Éditorial
New challenges in teaching architecture students in the third decade of the 21st Century	Gyurkovich,  J	Global Journal of Engineering Education	Commentary/Editorial| Commentaire/Éditorial
PMC7695548; Children and COVID19: Understanding impact on the growth trajectory of an evolving generation	Haleemunnissa,  S,  Didel, et al	Child Youth Serv Rev	Commentary/Editorial| Commentaire/Éditorial
Fast facts on COVID-19 and the Canadian Armed Forces	Halladay,  J,  Bélanger, et al	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
Financing sport post-COVID-19: using Modern Monetary Theory (MMT) to help make a case for economic recovery through spending on sport and recreation	Hammond,  AM	Managing Sport and Leisure	Commentary/Editorial| Commentaire/Éditorial
Modalities to restrain the progression of oral potentially malignant diseases and oral squamous cell carcinoma in COVID-19 pandemic	Hande,  A,  Sonone, et al	Oral oncology	Commentary/Editorial| Commentaire/Éditorial
Negotiating Livelihood during COVID-19 Urban Tribal Women Vendors of Manipur	Haokip,  H,  Haokip, et al	Economic and Political Weekly	Commentary/Editorial| Commentaire/Éditorial
End-Stage renal disease and 30-day mortality for adults with and without COVID-19	Harrison,  SL,  Buckley, et al	European journal of internal medicine	Commentary/Editorial| Commentaire/Éditorial
Embracing the new: Tips for biz growth in the COVID-19 ERA	Harrison,  T	Textile Services	Commentary/Editorial| Commentaire/Éditorial
PMC7709092; [Alice in the digital wonderland-pediatric teaching during the COVID-19 pandemic]	Häusler,  M,  Bosse, et al	Monatsschr Kinderheilkd	Commentary/Editorial| Commentaire/Éditorial
A Guide to Academic Crisis Response: Strategies for Nursing Schools During COVID-19 and Beyond	Hayes,  R,  McCauley, et al	Nurse Educ	Commentary/Editorial| Commentaire/Éditorial
The problem with relying on profit-driven models to produce pandemic drugs	Heled,  Y,  Rutschman, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
A public health framework for COVID-19 business liability	Hemel,  D,  Rodriguez, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and the kidneys: Risk, damage and sequelae	Herrera-Valdés,  R,  Almaguer-López, et al	MEDICC Review	Commentary/Editorial| Commentaire/Éditorial
The COVID-19 pandemic: How predictive analysis, artificial intelligence and GIS can be integrated into a clinical command system to improve disaster response and preparedness	Hertelendy,  AJ,  Goniewicz, et al	American Journal of Emergency Medicine	Commentary/Editorial| Commentaire/Éditorial
Follow the money. On the situation of disability rights in the United States	Herzog,  D	Geschichte und Gesellschaft	Commentary/Editorial| Commentaire/Éditorial
Wilderness Medicine Education in the Time of Social Distancing and COVID-19	Hill,  AD,  Pasik, et al	AEM Education and Training	Commentary/Editorial| Commentaire/Éditorial
[Functional disorders in previously healthy children during the COVID-19 pandemic]	Hjortebjerg,  MB,  Balslev, et al	Ugeskr Laeger	Commentary/Editorial| Commentaire/Éditorial
Non-visual access to graphical information on COVID-19	Holloway,  L,  Butler, et al		Commentary/Editorial| Commentaire/Éditorial
More that ACE2? NRP1 may play a central role in the underlying pathophysiological mechanism of olfactory dysfunction in COVID-19 and its association with enhanced survival	Hopkins,  C,  Lechien, et al	Medical hypotheses	Commentary/Editorial| Commentaire/Éditorial
Offline: COVID-19-what have we learned so far?	Horton,  R	Lancet	Commentary/Editorial| Commentaire/Éditorial
Letter to FSI re: “Can forensic science learn from the COVID-19 crisis?” Forensic Science International, V316, 2020	Houck,  MM	Forensic science international	Commentary/Editorial| Commentaire/Éditorial
Children with disabilities in the United States and the COVID-19 pandemic	Houtrow,  A,  Harris, et al	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
Challenge of caring for patients with severe mental illness during the COVID-19 epidemic in Taiwan	Huang,  MC,  Lin, et al	Asian Journal of Psychiatry	Commentary/Editorial| Commentaire/Éditorial
Special covid-19 edition	Hughes,  C	Family practice management	Commentary/Editorial| Commentaire/Éditorial
SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol)	Hyoju,  SK,  Zaborina, et al	Medical hypotheses	Commentary/Editorial| Commentaire/Éditorial
The European union in the face of global public health emergencies. The COVID-19 crisis	Iglesias,  MTP	Araucaria	Commentary/Editorial| Commentaire/Éditorial
Application technology to fight the COVID-19 pandemic: Lessons learned in Thailand	Intawong,  K,  Olson, et al	Biochemical and biophysical research communications	Commentary/Editorial| Commentaire/Éditorial
Implementation of Percutaneous Coronary Intervention during the COVID-19 Pandemic in Japan ― Nationwide Survey Report of the Japanese Association of Cardiovascular Intervention and Therapeutics for Cardiovascular Disease ―	Ishii,  H,  Amano, et al	Circulation Journal	Commentary/Editorial| Commentaire/Éditorial
Protocol for longitudinal assessment of SARS-CoV-2-specific immune responses in healthcare professionals in Hannover, Germany: the prospective, longitudinal, observational COVID-19 Contact (CoCo) study	Jablonka,  Alexandra,  Happle, et al	medRxiv	Commentary/Editorial| Commentaire/Éditorial
TrollHunter [Evader]: Automated Detection [Evasion] of TwitterTrolls During the COVID-19 Pandemic	Jachim,  Peter,  Sharevski, et al	arXiv	Commentary/Editorial| Commentaire/Éditorial
Dexmedetomidine: another arrow in the quiver to fight COVID-19 in intensive care units	Jain,  A,  Lamperti, et al	British journal of anaesthesia	Commentary/Editorial| Commentaire/Éditorial
Nonwovens industry responds to COVID-19 challenge	Jasti,  VK	Tappi Journal	Commentary/Editorial| Commentaire/Éditorial
AI-biometric driven Smartphone App for strict Post-COVID Home Quarantine Management	Jaswal,  G,  Bharadwaj, et al	IEEE Consumer Electronics Magazine	Commentary/Editorial| Commentaire/Éditorial
Ethical issues in the COVID-19 pandemic control preparedness in a developing economy	Jegede,  A,  Ajayi, et al	Pan African Medical Journal	Commentary/Editorial| Commentaire/Éditorial
COVID-19: Cutting through the noise	Jetly,  R	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
Twelve tips for teaching medical students online under COVID-19	Jiang,  Z,  Wu, et al	Med Educ Online	Commentary/Editorial| Commentaire/Éditorial
Legislating in the time of a pandemic: Window of opportunity or invitation for recklessness?	Johnson,  WG,  Marchant, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
School reopening during COVID-19 pandemic: Considering students with disabilities	Joline E,  ,  B, et al	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
Quick laboratory methodology for determining the particle filtration efficiency of face masks/respirators in the wake of COVID-19 pandemic	Joshi,  M,  Khan, et al	Journal of Industrial Textiles	Commentary/Editorial| Commentaire/Éditorial
Initial CT scan and its relationship with Covid-19	Kalemci,  S,  Sarıhan, et al	Heart and Lung	Commentary/Editorial| Commentaire/Éditorial
Disparities and ethical considerations for children with tracheostomies during the COVID-19 pandemic	Kana,  LA,  Shuman, et al	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
Letter from Japan	Kan-o,  K	Respirology	Commentary/Editorial| Commentaire/Éditorial
After the global crisis COVID 19 existential power of feeling as an inalienable right of human life	Karimov,  R,  Toshov, et al	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
Importance of storytelling: How to create more resilient cultural heritage?	Karzen,  M,  Demonja, et al	Nova Prisutnost	Commentary/Editorial| Commentaire/Éditorial
Impact of lockdown due to COVD-19 a century pandemic in India	Kaur,  J,  Mukherjee, et al	Annals of Tropical Medicine and Public Health	Commentary/Editorial| Commentaire/Éditorial
More than moving online: Implications of the COVID-19 pandemic on curriculum development	Keegan,  DA,  Bannister, et al	Medical education	Commentary/Editorial| Commentaire/Éditorial
An opportunity for change in medical education amidst COVID-19: Perspective of a medical student	Kelly,  K	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
The COVID-19 pandemic and death anxiety in the elderly	Khademi,  F,  Moayedi, et al	International Journal of Mental Health Nursing	Commentary/Editorial| Commentaire/Éditorial
Info-deficiency in an infodemic: The gender digital gap, arab women and the covid-19 pandemic	Khamis,  S,  Campbell, et al	Arab Media and Society	Commentary/Editorial| Commentaire/Éditorial
Prevention and Treatment Approaches in Children with the Coronavirus	Khosravi,  S,  Dezfouli, et al	Systematic Reviews in Pharmacy	Commentary/Editorial| Commentaire/Éditorial
The phenomenon of "motivation" in the learning process and its features (education in the context of Covid-19)	Khudayberganov,  A,  Ruzmetova, et al	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
European society of medical oncology (ESMO)	Kibble,  A	Drugs of the Future	Commentary/Editorial| Commentaire/Éditorial
PM Abe’s floundering pandemic leadership	Kingston,  J	Asia-Pasific Journal: Japan Focus	Commentary/Editorial| Commentaire/Éditorial
Consider liberalizing restraint use in intubated patients with COVID-19	Kinthala,  S,  Porter, et al	Nursing Critical Care	Commentary/Editorial| Commentaire/Éditorial
Implementation of ethical echo system to prevent and overcome crisis like Covid-19	Kiradoo,  G	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
Modeling consent in the time of COVID-19	Knoppers,  BM,  Beauvais, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Socio-psychological factors influencing the development of scientific and innovative thinking of young peopleafter the global crisis COVID 19	Komola,  F,  Dildora, et al	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
Cancer and COVID-19: Economic impact on households in Southeast Asia	Kong,  YC,  Sakti, et al	ecancermedicalscience	Commentary/Editorial| Commentaire/Éditorial
The impact of the Covid-19 pandemic on older workers: The role of self-regulation and organizations	Kooij,  DTAM	Work, Aging and Retirement	Commentary/Editorial| Commentaire/Éditorial
Use of Pharmacologic Agents With Weight Gain Potential for Panic Disorder Amid the COVID-19 Pandemic	Kow,  CS,  Hasan, et al	The primary care companion for CNS disorders	Commentary/Editorial| Commentaire/Éditorial
We are not in this together: Psychotherapy and pandemic emotions	Krupka,  Z	Psychotherapy and Politics International	Commentary/Editorial| Commentaire/Éditorial
Aortic thrombosis and renal infarction in a young female with patent foramen ovale and COVID-19 antibody	Kundal,  S,  Emeasoba, et al	Clinical Case Reports	Commentary/Editorial| Commentaire/Éditorial
Lessons learned...: Ideas inspired by COVID-19 that have a real value going forward	Kurjan,  E	Textile Services	Commentary/Editorial| Commentaire/Éditorial
The Japan Geriatrics Society consensus statement “recommendations for older persons to receive the best medical and long-term care during the COVID-19 outbreak—considering the timing of advance care planning implementation”	Kuzuya,  M,  Aita, et al	Geriatrics and Gerontology International	Commentary/Editorial| Commentaire/Éditorial
Reply to letter to the editor regarding New York's COVID-19 shelter-in-place and acute appendicitis in children	Kvasnovsky,  CL,  Shi, et al	Journal of pediatric surgery	Commentary/Editorial| Commentaire/Éditorial
Author Correction: A dynamic COVID-19 immune signature includes associations with poor prognosis (Nature Medicine, (2020), 26, 10, (1623-1635), 10.1038/s41591-020-1038-6)	Laing,  AG,  Lorenc, et al	Nature medicine	Commentary/Editorial| Commentaire/Éditorial
The New Normal	Langheinrich,  M	IEEE Pervasive Computing	Commentary/Editorial| Commentaire/Éditorial
Strengthening community engagement in Nepal during COVID-19: community-based training and development to reduce child labour	Larmar,  S,  Sunuwar, et al	Asia Pacific Journal of Social Work and Development	Commentary/Editorial| Commentaire/Éditorial
The Need for Recovering the Subjugated Knowledge of Traditional Chinese Medicine	Lau,  KC,  Sit, et al	Development (Basingstoke)	Commentary/Editorial| Commentaire/Éditorial
Implications of a pandemic outbreak risk: A discussion on china's emergency logistics in the era of coronavirus disease 2019 (COVID-19)	Lau,  Y,  Jiamian, et al	Journal of International Logistics and Trade	Commentary/Editorial| Commentaire/Éditorial
Conducting cross-cultural qualitative interviews with mainland Chinese participants during COVID: Lessons from the field	Lawrence,  L	Qualitative Research	Commentary/Editorial| Commentaire/Éditorial
Hematopoietic cell transplantation during COVID-19 pandemic: experience from a tertiary hospital in Madrid	Lázaro Del Campo,  P,  Ramírez López, et al	Expert Rev Hematol	Commentary/Editorial| Commentaire/Éditorial
Chronic alcohol use does not protect against COVID-19 infection	Lebin,  JA,  Mudan, et al	American Journal of Emergency Medicine	Commentary/Editorial| Commentaire/Éditorial
COVID-19 pandemic and derogation to human rights	Lebret,  A	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Course of symptoms for loss of sense of smell and taste over time in one thousand forty-one healthcare workers during the Covid-19 pandemic: Our experience	Lechner,  M,  Liu, et al	Clin Otolaryngol	Commentary/Editorial| Commentaire/Éditorial
Race/Ethnicity Among Children With COVID-19-Associated Multisystem Inflammatory Syndrome	Lee,  EH,  Kepler, et al	JAMA network open	Commentary/Editorial| Commentaire/Éditorial
The impact of COVID-19 in the management of AL amyloidosis and Immunoglobulin Deposition Disease: A single-center experience	Lee,  H,  Tay, et al	European journal of haematology	Commentary/Editorial| Commentaire/Éditorial
Triaging and adaptations of surveillance of cancer services in the COVID pandemic	Lewis,  S,  Gurram, et al	Journal of Radiotherapy in Practice	Commentary/Editorial| Commentaire/Éditorial
Response to “Letter to the Editor: Coronavirus disease 2019 (COVID-19) markedly increased mortality in patients with hip fracture: A systematic review and meta-analysis”	Lim,  MA,  Pranata, et al	Journal of Clinical Orthopaedics and Trauma	Commentary/Editorial| Commentaire/Éditorial
Commensurability, COVID, and the domestic: A note on scalarity	Linder,  B	Area	Commentary/Editorial| Commentaire/Éditorial
Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2	Liu,  K,  Zou, et al	ACS Pharmacology and Translational Science	Commentary/Editorial| Commentaire/Éditorial
COVID-19 in Civil or Commercial Disputes: First Responses from Chinese Courts	Liu,  Q	Chinese Journal of Comparative Law	Commentary/Editorial| Commentaire/Éditorial
Airborne microplastics from waste as a transmission vector for COVID-19	Liu,  Q,  Schauer, et al	Aerosol and Air Quality Research	Commentary/Editorial| Commentaire/Éditorial
Developing Competencies for Emotional, Instrumental, and Informational Student Support During the COVID-19 Pandemic: A Human Relations/Human Resource Development Approach	Lloyd-Jones,  B	Advances in Developing Human Resources	Commentary/Editorial| Commentaire/Éditorial
War, Heroes and Sacrifice: Masking Neoliberal Violence During the COVID-19 Pandemic	Lohmeyer,  BA,  Taylor, et al	Critical Sociology	Commentary/Editorial| Commentaire/Éditorial
Domestic violence and metaphysics	Lynes,  P	Derrida Today	Commentary/Editorial| Commentaire/Éditorial
Canadian Internal Medicine Ultrasound (CIMUS) Expert Consensus Statement on the Use of Lung Ultrasound for the Assessment of Medical Inpatients With Known or Suspected Coronavirus Disease 2019	Ma,  IWY,  Hussain, et al	J Ultrasound Med	Commentary/Editorial| Commentaire/Éditorial
Silent or 'happy' hypoxemia: An urgent dilemma for COVID-19 patient care	Machado-Curbelo,  C	MEDICC Review	Commentary/Editorial| Commentaire/Éditorial
Quality Healthcare Hospital Units and COVID-19 Pandemic. Should we reinvent ourselves?	Macías Maroto,  M	Journal of Healthcare Quality Research	Commentary/Editorial| Commentaire/Éditorial
Prevention, ability, and responsibility in times of corona	MacKert,  N,  Möhring, et al	Geschichte und Gesellschaft	Commentary/Editorial| Commentaire/Éditorial
COVID-19, POCUS, and Takotsubo	Madias,  JE	Am J Cardiol	Commentary/Editorial| Commentaire/Éditorial
Lung Ultrasound in Severe COVID-19 Pneumonia in the Sub-Intensive Care Unit: Beyond the Diagnostic Purpose	Magnani,  E,  Mattei, et al	Respiratory Medicine Case Reports	Commentary/Editorial| Commentaire/Éditorial
The ‘core’ of the ‘score’ (COVID-19)?	Magoon,  R	Medical hypotheses	Commentary/Editorial| Commentaire/Éditorial
Coping as the spouse of a military Veteran with PTSD during the COVID-19 pandemic	Maher,  P,  Lamrock, et al	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
Nephrotoxicity of chloroquine and hydroxychloroquine in COVID-19 patients	Mahmoudi,  J,  Sadigh-Eteghad, et al	Advanced Pharmaceutical Bulletin	Commentary/Editorial| Commentaire/Éditorial
About (dis)assembling games: COVID-19 and primary health care	Maia,  AC,  Agostini, et al	Physis	Commentary/Editorial| Commentaire/Éditorial
Loop - mediated isothermal amplification holds great potential for massive COVID - 19 diagnostics	Makarova,  JA,  Fomicheva, et al	Biotekhnologiya	Commentary/Editorial| Commentaire/Éditorial
COVID-19 in older adults: Typically atypical	Mandal,  AKJ,  Kho, et al	Geriatr Gerontol Int	Commentary/Editorial| Commentaire/Éditorial
COVID-19, European integration and populism	Manow,  P	Geschichte und Gesellschaft	Commentary/Editorial| Commentaire/Éditorial
Doing undoing	Mansfield,  N	Derrida Today	Commentary/Editorial| Commentaire/Éditorial
Restrictions on the free movement of persons in the EU during the COVID-19 era: Towards an uncertain future	Martín,  MM	Araucaria	Commentary/Editorial| Commentaire/Éditorial
Finding a New Normal: Hospital Governance Best Practices during COVID-19	Martin,  N	Healthcare quarterly (Toronto, Ont.)	Commentary/Editorial| Commentaire/Éditorial
Coronavirus disease 2019 and cardiac arrhythmias	Martínez-Rubio,  A,  Ascoeta, et al	European Cardiology Review	Commentary/Editorial| Commentaire/Éditorial
Impact of COVID-19 on mental health care for Veterans: Improvise, adapt, and overcome	McFarlane,  A,  Jetly, et al	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
Safe and effective medication utilization in pediatric patients requiring rehabilitation services during the Coronavirus pandemic of 2019	McLaughlin,  M	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
Venezuelan university in times of pandemic: Action or reaction? before the new normal	Meleán Romero,  R,  Contreras Bustamante, et al	Utopia y Praxis Latinoamericana	Commentary/Editorial| Commentaire/Éditorial
Immune Competence and Minimizing Susceptibility to COVID-19 and Other Immune System Threats	Meletis,  CD,  Wilkes, et al	Alternative Therapies in Health and Medicine	Commentary/Editorial| Commentaire/Éditorial
Status of vaccine development for COVID-19	Mendes,  A	Br J Community Nurs	Commentary/Editorial| Commentaire/Éditorial
The implications of COVID-19 for mental health status of an upper middle-income country, Peru	Mendoza-Saldaña,  JD,  Viton-Rubio, et al	Asian Journal of Psychiatry	Commentary/Editorial| Commentaire/Éditorial
Not infected but physically and mentally affected: Older cubans and COVID-19	Menéndez-Jiménez,  JE	MEDICC Review	Commentary/Editorial| Commentaire/Éditorial
Tele-mournings: Actuvirtual events and shared responsibilities	Mercier,  TC	Derrida Today	Commentary/Editorial| Commentaire/Éditorial
Land change science and SARS-CoV-2	Messina,  JP	Current Opinion in Environmental Sustainability	Commentary/Editorial| Commentaire/Éditorial
American College of Rheumatology Guidance for the Management of Rheumatic Disease in Adult Patients During the COVID-19 Pandemic: Version 3	Mikuls,  TR,  Johnson, et al	Arthritis Rheumatol	Commentary/Editorial| Commentaire/Éditorial
Proinflammatory cytokines and cardio-vascular risk: From myocardial infarction tocytokine storm of COVID-19	Miossec,  P	Bulletin de l'Academie nationale de medecine	Commentary/Editorial| Commentaire/Éditorial
Concept & impact of fixed charges and way forward for reduction of electricity tariff post COVID-19	Mishra,  BCK,  Singh, et al	Water and Energy International	Commentary/Editorial| Commentaire/Éditorial
Inhaled route and anti-inflammatory action of ivermectin: Do they hold promise in fighting against COVID-19?	Mittal,  N,  Mittal, et al	Medical hypotheses	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and the US Safety Net*	Moffitt,  RA,  Ziliak, et al	Fiscal Studies	Commentary/Editorial| Commentaire/Éditorial
Can we brand a pandemic? Should we? The case for corona virus, COVID-19 or SARS-CoV-2	Mogaji,  E,  Nguyen, et al	Journal of Public Affairs	Commentary/Editorial| Commentaire/Éditorial
Lessons from covid 19	Montalto,  SA	Malta Medical Journal	Commentary/Editorial| Commentaire/Éditorial
ALSCO-: Fighting back against COVID-19	Morgan,  J	Textile Services	Commentary/Editorial| Commentaire/Éditorial
Opportunities amid COVID-19: Advancing intra-African food integration	Morsy,  H,  Salami, et al	World Development	Commentary/Editorial| Commentaire/Éditorial
Changes in the office for civil rights enforcement policy on telehealth remote communications in response to COVID-19	Mortell,  TJ,  Strobel, et al	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
COVID-19 vaccines buoy hope	Mullard,  A	Nat Rev Drug Discov	Commentary/Editorial| Commentaire/Éditorial
Peripheral Blood Smear in COVID-19: a Comment	Mungmunpuntipantip,  R,  Wiwanitkit, et al	Turk J Haematol	Commentary/Editorial| Commentaire/Éditorial
Planning for classroom physical distancing to minimize the threat of COVID-19 disease spread	Murray,  AT	PLoS One	Commentary/Editorial| Commentaire/Éditorial
Epidemiology's time of need: COVID-19 calls for epidemic-related economics	Murray,  EJ	Journal of Economic Perspectives	Commentary/Editorial| Commentaire/Éditorial
Covid, racism and Black Lives Matter: A deadly constellation	Music,  G	Developmental Child Welfare	Commentary/Editorial| Commentaire/Éditorial
For your information: How presentation folders and brochures are proving vital as the nation battles COVID-19	Myers,  J	Print and Promo	Commentary/Editorial| Commentaire/Éditorial
Corona vitae / Corona mortis	Naas,  M	Derrida Today	Commentary/Editorial| Commentaire/Éditorial
Effects of COVID-19 pandemic on adherence to obstructive sleep apnea therapy: A case report	Naime,  S,  Weiss, et al	Clinical Case Reports	Commentary/Editorial| Commentaire/Éditorial
PMC7708233; COVID-19 in New Orleans: A Nephrology Clinical and Education Perspective and Lessons Learned	Naljayan,  M,  Yazdi, et al	Kidney Med	Commentary/Editorial| Commentaire/Éditorial
Author's reply: Diagnosing Covid-19 associated Guillain-Barre syndrome	Nanda,  S,  Handa, et al	American Journal of Emergency Medicine	Commentary/Editorial| Commentaire/Éditorial
Biological resources - COVID-19. Legal support of biological resources for scientific purposes and biological safety	Narzullaev,  O	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
Optimizing intraoral surgery video recording for residents’ training during the COVID-19 pandemic: Comparison of 3 point of views using a GoPro	Navia,  A,  Parada, et al	Journal of Plastic, Reconstructive and Aesthetic Surgery	Commentary/Editorial| Commentaire/Éditorial
Are tracheal intubation and extubation aerosol-generating procedures?	Nestor,  CC,  Wang, et al	Anaesthesia	Commentary/Editorial| Commentaire/Éditorial
Intra-articular corticosteroid injections during the COVID-19 lockdown period: A service evaluation	Newton,  AC,  Jones, et al	Musculoskeletal Care	Commentary/Editorial| Commentaire/Éditorial
Addressing racial & socioeconomic disparities in access to medications for opioid use disorder amid COVID-19	Nguemeni Tiako,  MJ	Journal of substance abuse treatment	Commentary/Editorial| Commentaire/Éditorial
Un Cas de COVID-19 compliqué d´embolie avec Deux tests PCR initialement négatifs malgré des signes scanographiques	Niang,  I,  Thioub, et al	Pan African Medical Journal	Commentary/Editorial| Commentaire/Éditorial
PMC7709600; Comments on 'Development of a PCR-RFLP method for detection of D614G mutation in SARS-CoV-2'	Niranji,  SS,  Al-Jaf, et al	Infect Genet Evol	Commentary/Editorial| Commentaire/Éditorial
Video visits and access to care in pediatric rehabilitation therapies in the time of a pandemic	Nulle,  J,  Nelson, et al	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
Suppression, Spikes, and Stigma: How COVID-19 Will Shape International Migration and Hostilities toward It	O’Brien,  ML,  Eger, et al	International Migration Review	Commentary/Editorial| Commentaire/Éditorial
The Impact Of Covid-19 On The Practice Of Dermatology In Sub-Saharan Africa	Oaku,  I,  Anaba, et al	Dermatol Ther	Commentary/Editorial| Commentaire/Éditorial
Zebra-like bodies in COVID-19: is phospholipidosis evidence of hydroxychloroquine induced acute kidney injury?	Obeidat,  M,  Isaacson, et al	Ultrastruct Pathol	Commentary/Editorial| Commentaire/Éditorial
Food insecurity and social injustice: The plight of urban poor African immigrants in South Africa during the COVID-19 crisis	Odunitan-Wayas,  F,  Alaba, et al	Glob Public Health	Commentary/Editorial| Commentaire/Éditorial
COVID-19 Disruptions to Clinical Education: Nurse Educators Rise to the Challenges	Oermann,  MH	Nurse Educ	Commentary/Editorial| Commentaire/Éditorial
Reducing immunosuppressant use in patients with chronic inflammation during the COVID-19 pandemic: Risks versus benefits	Ogawa-Momohara,  M,  Muro, et al	Journal of Cutaneous Immunology and Allergy	Commentary/Editorial| Commentaire/Éditorial
Media representations of COVID-19 public health policies: assessing the portrayal of essential health services in Canadian print media	Ogbogu,  Ubaka,  Hardcastle, et al	Research Square prepub	Commentary/Editorial| Commentaire/Éditorial
The impacts of COVID-19 pandemic on marine litter pollution along the Kenyan Coast: A synthesis after 100 days following the first reported case in Kenya	Okuku,  E,  Kiteresi, et al	Marine pollution bulletin	Commentary/Editorial| Commentaire/Éditorial
Tellende e-læringskurs i covid-19-håndtering for leger	Ophaug,  L	Tidsskrift for den Norske laegeforening	Commentary/Editorial| Commentaire/Éditorial
Should beach travel in the Philippines resume during the COVID-19 outbreak?	Opiniano,  GA,  Biana, et al	Public health	Commentary/Editorial| Commentaire/Éditorial
Engaging Communities in Challenging Times: Lessons Learned from the Master Gardener Program During the COVID-19 Pandemic	Osafo,  E	Advances in Developing Human Resources	Commentary/Editorial| Commentaire/Éditorial
Impressions of a Veteran recovering from operational stress injuries during the COVID-19 pandemic	Osborne,  K	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
Yoga: The Antidote for These Times	Ovissi,  M	World Medical and Health Policy	Commentary/Editorial| Commentaire/Éditorial
What should be the mask types, features and standards recommended for health İnstitutions and for the general population during the COVID-19 pandemic?	Özer,  A,  Hacımustafaoğlu, et al	Cocuk Enfeksiyon Dergisi	Commentary/Editorial| Commentaire/Éditorial
Time to challenge our approaches to education	Palermo,  C	Med Educ	Commentary/Editorial| Commentaire/Éditorial
“There was an adventure in this challenge”	Pallaro,  A	Soins Pediatrie/Puericulture	Commentary/Editorial| Commentaire/Éditorial
Reply to "Does MAFLD really increase the severity of COVID-19?"	Pan,  L,  Huang, et al	Digestive and Liver Disease	Commentary/Editorial| Commentaire/Éditorial
How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis	Panariello,  F,  Cellini, et al	Frontiers in Psychiatry	Commentary/Editorial| Commentaire/Éditorial
PMC7710470; Collaboration During Crisis: A Novel Point-of-Care Ultrasound Alliance Between Emergency Medicine, Internal Medicine, and Cardiology in the COVID-19 Era	Panebianco,  N,  Baston, et al	J Am Soc Echocardiogr	Commentary/Editorial| Commentaire/Éditorial
COVID-IP: Staring down the Bayh-Dole Act with 2020 vision	Paradise,  J	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
PMC7709881; Association of social containment on ST-segment elevation myocardial infarction presentations during the COVID-19 pandemic	Pareek,  N,  Yeoh, et al	Coron Artery Dis	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and the EU. On the history of a horizon of expectations	Patel,  KK	Geschichte und Gesellschaft	Commentary/Editorial| Commentaire/Éditorial
Europe’s essential workers: Migration and pandemic politics in Central and Eastern Europe during COVID-19	Paul,  R	European Policy Analysis	Commentary/Editorial| Commentaire/Éditorial
Possibilities of bim-fm for the management of covid in public buildings	Pavón,  RM,  Alvarez, et al	Sustainability (Switzerland)	Commentary/Editorial| Commentaire/Éditorial
Safeguarding children under Covid-19: What are we learning?	Pearce,  J,  Miller, et al	Journal of Children's Services	Commentary/Editorial| Commentaire/Éditorial
Chloroquine, the Coronavirus Crisis, and Neurodegeneration: A Perspective	Pedrioli,  G,  Patani, et al	Frontiers in Neurology	Commentary/Editorial| Commentaire/Éditorial
Lockdown During COVID-19 and the Increase of Frailty in People With Neurological Conditions	Pelicioni,  PHS,  Schulz-Moore, et al	Frontiers in Neurology	Commentary/Editorial| Commentaire/Éditorial
COVID-19, your pet and other animals: Are you at risk?	Percedo-Abreu,  M	MEDICC Review	Commentary/Editorial| Commentaire/Éditorial
Learning from history? The role of historians in times of crisis	Pernau,  M	Geschichte und Gesellschaft	Commentary/Editorial| Commentaire/Éditorial
Prejudice and pandemic in the promised land: how white Christian nationalism shapes Americans’ racist and xenophobic views of COVID-19	Perry,  SL,  Whitehead, et al	Ethnic and Racial Studies	Commentary/Editorial| Commentaire/Éditorial
Traditional foods at the click of a button: The preference for the online purchase of romanian traditional foods during the COVID-19 pandemic	Petrescu-Mag,  R,  Vermeir, et al	Sustainability (Switzerland)	Commentary/Editorial| Commentaire/Éditorial
Grief: The Epidemic Within an Epidemic	Petry,  SE,  Hughes, et al	Am J Hosp Palliat Care	Commentary/Editorial| Commentaire/Éditorial
A COVID-19 vaccine-dare to dream	Phillis,  A	Br J Community Nurs	Commentary/Editorial| Commentaire/Éditorial
Editor-in-Chief's Editorial to the Special Issue: COVID-19's Impact on the Practice of Pediatric Rehabilitation Medicine	Pico,  EL	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
Population data mobility retrieval at territory of Czechia in pandemic COVID-19 period	Platos,  J,  Kromer, et al	Concurrency Computation	Commentary/Editorial| Commentaire/Éditorial
From the editors covid-19 pandemic	Ponce,  HD	Enfermedades Infecciosas y Microbiologia	Commentary/Editorial| Commentaire/Éditorial
Equipment cover-up for ultrasound use in COVID-19 patients	Postigo,  TLR,  Diáz, et al	Angiologia	Commentary/Editorial| Commentaire/Éditorial
Teaching, virtually: a critical reflection	Powell,  L,  McGuigan, et al	Accounting Research Journal	Commentary/Editorial| Commentaire/Éditorial
Letter to the Editor: Integrating the Roles of Pharmacy Practice and Drug Delivery in Mitigating COVID-19	Prasher,  P,  Sharma, et al	Alternative Therapies in Health and Medicine	Commentary/Editorial| Commentaire/Éditorial
COVID in crisis: The impact of COVID-19 in complex humanitarian emergencies	Pritchard,  J,  Collier, et al	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
Pediatric telerehabilitation medicine: Making your virtual visits efficient, effective and fun	Rabatin,  AE,  Lynch, et al	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
The Pandemic and Economic Fallout in South Asia Challenges and the Way Forward	Raihan,  S,  Wignaraja, et al	Economic and Political Weekly	Commentary/Editorial| Commentaire/Éditorial
Specificities of the reorganization of care for cancer patients during the pandemic COVID-19 in a regional center of oncology in Morocco	Rais,  G,  Amaoui, et al	Pan African Medical Journal	Commentary/Editorial| Commentaire/Éditorial
Coping with COVID-19: a reflection on learning challenges and coping strategies – the case of an accounting conversion masters degree in New Zealand	Ramachandra,  S,  Wells, et al	Accounting Research Journal	Commentary/Editorial| Commentaire/Éditorial
Impact of COVID-19 on Migrant Labourers of India and China	Ranjan,  R	Critical Sociology	Commentary/Editorial| Commentaire/Éditorial
Traqueostomy in COVID-19 patients: Current recomendations	Rappoport W,  ,  D, et al	Revista de Cirugia	Commentary/Editorial| Commentaire/Éditorial
Fighting from the covid-19 frontline: A junior doctor’s perspective on fear, duty and calling	Rasappan,  K,  Oh, et al	Malaysian Orthopaedic Journal	Commentary/Editorial| Commentaire/Éditorial
Field epidemiology and COVID-19: always more lessons to be learned	Rasmussen,  SA,  Goodman, et al	Int J Epidemiol	Commentary/Editorial| Commentaire/Éditorial
The Impact of COVID-19 Pandemic Infection in Patients Admitted to the Hospital for Reasons Other Than COVID-19 Infection	Rawat,  S,  Singh Dhramshaktu, et al	Alternative Therapies in Health and Medicine	Commentary/Editorial| Commentaire/Éditorial
A PAHO perspective on COVID-19 in Cuba José Moya MD MPH PhD	Reed,  GA	MEDICC Review	Commentary/Editorial| Commentaire/Éditorial
Author Correction: Modeling COVID-19 scenarios for the United States (Nature Medicine, (2020), 10.1038/s41591-020-1132-9)	Reiner,  RC,  J, et al	Nature medicine	Commentary/Editorial| Commentaire/Éditorial
Considerations in mandating a new Covid-19 vaccine in the USA for children and adults	Reiss,  DR,  Caplan, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
To stop the next pandemic, we need to unravel the origins of COVID-19	Relman,  DA	Proceedings of the National Academy of Sciences of the United States of America	Commentary/Editorial| Commentaire/Éditorial
The growth of creative micro, small, and medium enterprises (Msmes) business in special region of yogyakarta before and after covid-19 pandemic	Resmi,  S,  Pahlevi, et al	International Journal of Entrepreneurship	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and the Twin Transition: How the Recovery Can Boost Sustainable and Inclusive Growth	Revoltella,  D	Intereconomics	Commentary/Editorial| Commentaire/Éditorial
COVID pandemic in accommodation facilities for dependent elderly	Reynaud-Lévy,  O,  Herdt, et al	Soins Gerontologie	Commentary/Editorial| Commentaire/Éditorial
Telemedicine as a concrete response to covids-19 pandemic	Ricci,  G,  Campanozzi, et al	Rivista Italiana di Medicina Legale e del Diritto in Campo Sanitario	Commentary/Editorial| Commentaire/Éditorial
Major fall in urgent skin cancer referrals during the COVID-19 outbreak	Rich,  H,  O'Neill, et al	Journal of Plastic, Reconstructive and Aesthetic Surgery	Commentary/Editorial| Commentaire/Éditorial
The diary of an operational stress injury clinic psychiatrist during the COVID-19 pandemic	Richardson,  JD	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
Epilepsy and covid-19: Patient management and optimization of antiepileptic therapy during pandemic	Rider,  FK,  Lebedeva, et al	Zhurnal Nevrologii i Psihiatrii imeni S.S.Korsakova	Commentary/Editorial| Commentaire/Éditorial
Reflections on Practice during a Pandemic: How do we Continue to Ensure Effective Communication during the COVID-19 Pandemic?	Roberts,  W	Child Abuse Review	Commentary/Editorial| Commentaire/Éditorial
Indemnifying precaution: Economic insights for regulation of a highly infectious disease	Robertson,  CT,  Schaefer, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Delivering rehabilitation services during the COVID-19 pandemic: How CAF Physiotherapy is using telehealth to ensure "physical and measurable solutions to maintain and enhance operational readiness, anywhere, anytime"	Robitaille,  E,  MacRae, et al	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Nervous System: Implications of COVID-19 in Neurodegeneration	Rodriguez,  M,  Soler, et al	Frontiers in Neurology	Commentary/Editorial| Commentaire/Éditorial
Endocrine cancer surgery complicated by COVID-19: Lessons from the initial phase of the outbreak	Rodríguez-Hermosa,  JI,  Planellas-Giné, et al	European Journal of Surgical Oncology	Commentary/Editorial| Commentaire/Éditorial
Gender-based violence during COVID-19 outbreak in Spain	Rodriguez-Jimenez,  R,  Fares-Otero, et al	Psychol Med	Commentary/Editorial| Commentaire/Éditorial
Why will it never be known if convalescent plasma is effective for COVID-19	Rojas,  M,  Anaya, et al	Journal of Translational Autoimmunity	Commentary/Editorial| Commentaire/Éditorial
crise sanitaireDe l'importance de parler de la Covid-19 aux enfants: le rôle essentiel de l'assistante maternelle	Romano,  H	Metiers de la Petite Enfance	Commentary/Editorial| Commentaire/Éditorial
Extrapulmonary manifestations of severe acute respiratory syndrome coronavirus-2 infection	Rosen,  HR,  O'Connell, et al	Journal of medical virology	Commentary/Editorial| Commentaire/Éditorial
Challenges to neo-liberalism in the United States	Rosenberg,  S	International Review of Applied Economics	Commentary/Editorial| Commentaire/Éditorial
Practice implications and clinical observations: Virtual care for a military/Veteran population during the COVID-19 pandemic	Roth,  M	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
In this issue—2020 draws to a close	Rovin,  BH	Kidney international	Commentary/Editorial| Commentaire/Éditorial
Crafting the Taiwan model for COVID-19: An exceptional state in pandemic territory	Rowen,  I	Asia-Pasific Journal: Japan Focus	Commentary/Editorial| Commentaire/Éditorial
The impact of COVID-19 on the foodservice industry in Vancouver, British Columbia, Canada	Roy,  H,  Gupta, et al	Anatolia	Commentary/Editorial| Commentaire/Éditorial
This will still be true tomorrow: “Fukushima Ain’t got the time for olympic games”: Two texts on nuclear disaster and pandemic	Ruiko,  M	Asia-Pasific Journal: Japan Focus	Commentary/Editorial| Commentaire/Éditorial
Ultra-rapid development and deployment of a family resilience program during the COVID-19 pandemic: Lessons learned from Families Tackling Tough Times Together	Ruiz,  Y,  Wadsworth, et al	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
Knowledge, awareness and impact of epidemic outbreak among undergraduates	Ruskin,  P,  Venkatesh, et al	European Journal of Molecular and Clinical Medicine	Commentary/Editorial| Commentaire/Éditorial
AAID White Paper: Management of the Dental Implant Patient During the COVID-19 Pandemic and Beyond	Rutkowski,  JL,  Camm, et al	The Journal of oral implantology	Commentary/Editorial| Commentaire/Éditorial
Caring for women with substance use disorders through pregnancy and postpartum during the COVID-19 pandemic: Lessons learned from psychology trainees in an integrated OBGYN/substance use disorder outpatient treatment program	Sadicario,  JS,  Parlier-Ahmad, et al	Journal of substance abuse treatment	Commentary/Editorial| Commentaire/Éditorial
SARS-CoV-2: Future potential impact on timing of menarche and onset of the regular menstrual cycle in adolescents	Saei Ghare Naz,  M,  Ramezani Tehrani, et al	Journal of pediatric nursing	Commentary/Editorial| Commentaire/Éditorial
Should neurological affection be considered in SARS-CoV-2 infection?	Sáenz-López,  JD,  Tatis-Villamizar, et al	Revista Ecuatoriana de Neurologia	Commentary/Editorial| Commentaire/Éditorial
Fear of childbirth amid COVID-19 in India: Neglected aspect of maternal mental health	Saha,  R,  Jungari, et al	Int J Soc Psychiatry	Commentary/Editorial| Commentaire/Éditorial
In search of other respiratory viruses during the COVID-19 pandemic	Saint-Pierre Contreras,  G,  Muñoz Gomez, et al	Revista clinica espanola	Commentary/Editorial| Commentaire/Éditorial
Correction to: A survival analysis of COVID-19 in the Mexican population (BMC Public Health, (2020), 20, 1, (1616), 10.1186/s12889-020-09721-2)	Salinas-Escudero,  G,  Carrillo-Vega, et al	BMC Public Health	Commentary/Editorial| Commentaire/Éditorial
Understanding the dynamics of COVID-19; implications for therapeutic intervention, vaccine development and movement control	Salvamani,  S,  Tan, et al	British journal of biomedical science	Commentary/Editorial| Commentaire/Éditorial
Latin America and the European Union: Social Agendas, Geopolitical Contest, and COVID-19	Sanahuja,  JA	Araucaria	Commentary/Editorial| Commentaire/Éditorial
The application of the inbound marketing strategy on costa del sol planning & tourism board. Lessons for post-covid-19 revival	Sánchez-Teba,  EM,  García-Mestanza, et al	Sustainability (Switzerland)	Commentary/Editorial| Commentaire/Éditorial
British government communication during the 2020 COVID-19 pandemic: learning from high reliability organizations	Sanders,  KB	Church, Communication and Culture	Commentary/Editorial| Commentaire/Éditorial
From the editors Influenza Vaccine in the COVID 19 Pandemic	Santos,  FS,  Mota, et al	Enfermedades Infecciosas y Microbiologia	Commentary/Editorial| Commentaire/Éditorial
Labor market and unpaid works implications of COVID-19 for Bangladeshi women	Sarker,  MR	Gender, Work and Organization	Commentary/Editorial| Commentaire/Éditorial
Novel Viewpoints on Tobacco Smoking and COVID-19	Sarode,  S,  Sarode, et al	Journal of Contemporary Dental Practice	Commentary/Editorial| Commentaire/Éditorial
Digitalising diabetes support groups in response to the coronavirus COVID-19 outbreak: a collaborative initiative	Sauchelli,  S	Practical Diabetes	Commentary/Editorial| Commentaire/Éditorial
Countering fake news in the COVID-19 era: The public's opinion on the role of an honest and reliable website	Scerri,  M,  Grech, et al	Early human development	Commentary/Editorial| Commentaire/Éditorial
A plea to apply principles of quarantine ethics to prisoners and immigration detainees during the COVID-19 crisis	Schotland,  SD	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
The geography of the US’s mishandling of COVID-19: A commentary on the politics of science in democracies	Schrager,  B	Geographical Journal	Commentary/Editorial| Commentaire/Éditorial
Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators	Schwarz,  B,  Sharma, et al	J Immunol	Commentary/Editorial| Commentaire/Éditorial
Worship in a post-lockdown context: A ritual-liturgical perspective	Scott,  HR	HTS Teologiese Studies / Theological Studies	Commentary/Editorial| Commentaire/Éditorial
Challenges and Opportunities From COVID-19 for Global Sustainable Development	Seshaiyer,  P,  McNeely, et al	World Medical and Health Policy	Commentary/Editorial| Commentaire/Éditorial
Headache Due to COVID-19: A Disabling Combination	Seth,  V,  Kushwaha, et al	Headache	Commentary/Editorial| Commentaire/Éditorial
Psychological Health Among Gastroenterologists During the COVID-19 Pandemic: A National Survey	Shah,  ED,  Pourmorteza, et al	Clin Gastroenterol Hepatol	Commentary/Editorial| Commentaire/Éditorial
Indian media coverage of Nizamuddin Markaz event during COVID-19 pandemic	Sharma,  P,  Anand, et al	Asian Politics and Policy	Commentary/Editorial| Commentaire/Éditorial
COVID-19 complicated by acute arterial thrombosis: Therapeutic challenges	Shereef,  H,  Subahi, et al	IJC Heart and Vasculature	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and structured finance litigation: CMBS and CLO disputes on the horizon	Sheth,  MM,  Futter, et al	Journal of Structured Finance	Commentary/Editorial| Commentaire/Éditorial
PMC7716109; Asynchronous actions of immune responses in COVID-19 patients	Shi,  Y,  Zhou, et al	Signal Transduct Target Ther	Commentary/Editorial| Commentaire/Éditorial
Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19	Shirbhate,  E,  Patel, et al	Mini Rev Med Chem	Commentary/Editorial| Commentaire/Éditorial
Collaborative planning principles for disaster preparedness	Shmueli,  DF,  Ozawa, et al	International Journal of Disaster Risk Reduction	Commentary/Editorial| Commentaire/Éditorial
Emergency Psychiatry During COVID-19 in Developing Countries	Shoib,  S,  Arafat, et al	Revista Colombiana de Psiquiatria	Commentary/Editorial| Commentaire/Éditorial
COVID-19: A double threat to takotsubo cardiomyopathy and spontaneous coronary artery dissection?	Shojaei,  F,  Habibi, et al	Medical hypotheses	Commentary/Editorial| Commentaire/Éditorial
Workplace well-being in pediatric anesthesia: How to design and implement a bespoke evidence-based framework in your department	Shrivastava,  PP,  McDonald, et al	Paediatric anaesthesia	Commentary/Editorial| Commentaire/Éditorial
Telemedicine in reproductive medicine—implications for technology and clinical practice	Sigman,  M	Fertility and sterility	Commentary/Editorial| Commentaire/Éditorial
General recommendations in head & neck oncologic surgery during covid-19 pandemic	Silva-Figueroa,  A,  Gallego-Cifuentes, et al	Revista de Cirugia	Commentary/Editorial| Commentaire/Éditorial
COVID-19 pandemic: Burnout syndrome in healthcare professionals working in field hospitals in Brazil	Silva-Gomes,  R,  Silva-Gomes, et al	Enfermeria Clinica	Commentary/Editorial| Commentaire/Éditorial
PMC7713543; Modeling Multi-organ Infection by SARS-CoV-2 Using Stem Cell Technology	Simoneau,  CR,  Ott, et al	Cell Stem Cell	Commentary/Editorial| Commentaire/Éditorial
Hydroxychloroquine for prophylaxis and treatment of COVID-19 in health-care workers	Simova,  I,  Vekov, et al	New Microbes and New Infections	Commentary/Editorial| Commentaire/Éditorial
COVID-19 Pandemic and Child Neurology Training: A Bumpy Road Ahead	Singanamalla,  B,  Madaan, et al	Pediatric neurology	Commentary/Editorial| Commentaire/Éditorial
Virtual parent-child visitation in support of family reunification in the time of COVID-19	Singer,  J,  Brodzinsky, et al	Developmental Child Welfare	Commentary/Editorial| Commentaire/Éditorial
MVP Architecture Model with Single Endpoint Access for Displaying COVID 19 Patients Information Dynamically	Singh,  A,  Jeyanthi, et al		Commentary/Editorial| Commentaire/Éditorial
PMC7709597; ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease	Singh,  H,  Choudhari, et al	Microb Pathog	Commentary/Editorial| Commentaire/Éditorial
Impact of COVID-19 on the travel and tourism industry	Škare,  M,  Soriano, et al	Technological Forecasting and Social Change	Commentary/Editorial| Commentaire/Éditorial
Economic Recovery in the Age of COVID-19	Skidelsky,  R	Intereconomics	Commentary/Editorial| Commentaire/Éditorial
Creation, destruction, and COVID-19: Heeding the call of country, bringing things into balance	Smith,  AS,  Smith, et al	Geographical Research	Commentary/Editorial| Commentaire/Éditorial
Mindfulness in the face of COVID-19	Smith,  GD	Gastrointestinal Nursing	Commentary/Editorial| Commentaire/Éditorial
Impact of the COVID-19 pandemic on Spanish Nephrology Services	Soler,  MJ,  Macia Heras, et al	Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia	Commentary/Editorial| Commentaire/Éditorial
Towards automated, provenance-driven security audit for git-based repositories: Applied to germany's corona-warn-App: Vision paper	Sonnekalb,  T,  Heinze, et al		Commentary/Editorial| Commentaire/Éditorial
Nurse Practitioner COVID-19 Experience in Skilled Nursing Facilities	Spear,  RA,  Schmuecker, et al	Journal for Nurse Practitioners	Commentary/Editorial| Commentaire/Éditorial
The experience of UK patients with bladder cancer during the COVID-19 pandemic: a survey-based snapshot	Spencer-Bowdage,  S,  Russell, et al	BJU international	Commentary/Editorial| Commentaire/Éditorial
Influence of room ventilation settings on aerosol clearance and distribution	Sperna Weiland,  NH,  Traversari, et al	British journal of anaesthesia	Commentary/Editorial| Commentaire/Éditorial
What we keep forgetting: Pandemics, rivers and roots	Staikou,  E	Derrida Today	Commentary/Editorial| Commentaire/Éditorial
Between a rock and a hard place: COVID-19 and South Africa's response	Staunton,  C,  Swanepoel, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
The psychoethics of syndemic: The pathic and the pathological	Stepke,  FL	Acta Bioethica	Commentary/Editorial| Commentaire/Éditorial
The use of data from electronic health records in times of a pandemic-a legal and ethical assessment	Stoeger,  K,  Schmidhuber, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Pediatric neuromuscular disorders: Care considerations during the COVID-19 pandemic	Stratton,  AT,  Roberts Iii, et al	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
The virus and digitization - is Corona driving the digital evolution of the German healthcare system?	Straub,  C	Gesundheitsokonomie und Qualitatsmanagement	Commentary/Editorial| Commentaire/Éditorial
Disparities Old and New in US Mental Health during the COVID-19 Pandemic*	Swaziek,  Z,  Wozniak, et al	Fiscal Studies	Commentary/Editorial| Commentaire/Éditorial
Canadian ophthalmology resident experience during the COVID-19 pandemic	Szigiato,  AA,  Palakkamanil, et al	Canadian Journal of Ophthalmology	Commentary/Editorial| Commentaire/Éditorial
Rapid and label-free detection of COVID-19 using coherent anti-Stokes Raman scattering microscopy	Tabish,  TA,  Narayan, et al	MRS Communications	Commentary/Editorial| Commentaire/Éditorial
Mr Tahir Taghizade, Ambassador of Azerbaijan in the UK, writes in response to "War in the time of COVID-19: humanitarian catastrophe in Nagorno-Karabakh and Armenia"	Taghizade,  T	Lancet Glob Health	Commentary/Editorial| Commentaire/Éditorial
PMC7713542; Introductions to the Community: Early-Career Researchers in the Time of COVID-19	Takayama,  K,  Weaver, et al	Cell Stem Cell	Commentary/Editorial| Commentaire/Éditorial
Blood supply management during the Covid-19 pandemic: Experience in a tertiary referral hospital in Malaysia	Tan,  PP,  Chang, et al	Transfusion and Apheresis Science	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and healthcare lessons already learned	Terry,  N	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
ASE Membership in the COVID-19 Pandemic: Hanging out, Hanging on, Together	Thamman,  R,  Anderson, et al	Journal of the American Society of Echocardiography	Commentary/Editorial| Commentaire/Éditorial
Coronavirus vaccine? Join the queue	The Lancet,  Diabetes,  amp, et al	The Lancet Diabetes & Endocrinology	Commentary/Editorial| Commentaire/Éditorial
Climate and COVID-19: converging crises	The,  Lancet	Lancet	Commentary/Editorial| Commentaire/Éditorial
Roadmap out of covid-19	Thor,  J,  Pagkaliwagan, et al	Malaysian Orthopaedic Journal	Commentary/Editorial| Commentaire/Éditorial
Student and Teacher Perspectives of Learning ASL in an Online Setting	Tigwell,  GW,  Peiris, et al		Commentary/Editorial| Commentaire/Éditorial
Business-as-Usual will not Deliver the COVID-19 Vaccines We Need	Torreele,  E	Development (Basingstoke)	Commentary/Editorial| Commentaire/Éditorial
Fallen in the face of COVID-19: Graduates of Cuba's Latin American School of Medicine (ELAM)	Torres,  EJF,  Ruiz, et al	MEDICC Review	Commentary/Editorial| Commentaire/Éditorial
Welcome to the 13th Volume of Immunotherapy	Torrington,  E	Immunotherapy	Commentary/Editorial| Commentaire/Éditorial
Covid-19, from the block to the battlefront	Triboulin,  G,  Bala, et al	Inter Bloc	Commentary/Editorial| Commentaire/Éditorial
Equity in clinical practice requires organisational and system-level change – The role of nurse leaders	Truong,  M,  Bourke, et al	Collegian	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and its implications for research on work ability	Truxillo,  DM,  Cadiz, et al	Work, Aging and Retirement	Commentary/Editorial| Commentaire/Éditorial
The role of respiratory therapists in fighting the covid-19 crisis: Unsung heroes in Wuhan	Tu,  GW,  Liu, et al	Annals of Palliative Medicine	Commentary/Editorial| Commentaire/Éditorial
What Really Changed? Environments, Instruction, and 21st Century Tools in Emergency Online English Language Arts Teaching in United States Schools During the First Pandemic Response	Turchi,  LB,  Bondar, et al	Frontiers in Education	Commentary/Editorial| Commentaire/Éditorial
PMC7454287; Rising to the challenge: Pharmacy residents on the front lines during COVID-19 pandemic	Uchida,  E,  Long-Fazio, et al	Am J Health Syst Pharm	Commentary/Editorial| Commentaire/Éditorial
Kawasaki disease following coronavirus disease 2019 with prolonged fecal viral shedding	Uda,  K,  Okita, et al	Pediatr Int	Commentary/Editorial| Commentaire/Éditorial
Mechanogenomic coupling of lung tissue stiffness, EMT and coronavirus pathogenicity	Uhler,  C,  Shivashankar, et al	Current Opinion in Solid State and Materials Science	Commentary/Editorial| Commentaire/Éditorial
Telemedicine technology and implications for reproductive office operations	Uustal,  M,  Blackmon, et al	Fertility and sterility	Commentary/Editorial| Commentaire/Éditorial
E-pediatric neurorehabilitation: Boon to parents and children with cerebral palsy in covid-19 era	Vadivelan,  K,  Sekar, et al	Revista Pesquisa em Fisioterapia	Commentary/Editorial| Commentaire/Éditorial
Religion and pandemic. State, religion, and society in Saudi Arabia and Iran during the coronavirus crisis	Van Den Heuvel,  N,  Freitag, et al	Geschichte und Gesellschaft	Commentary/Editorial| Commentaire/Éditorial
The rise and regulation of thermal facial recognition technology during the COVID-19 pandemic	Van Natta,  M,  Chen, et al	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Family perspectives of COVID-19 research	Vanderhout,  SM,  Birken, et al	Research Involvement and Engagement	Commentary/Editorial| Commentaire/Éditorial
Informer les proches des résidents en Ehpad pendant le confinement	Vasseur,  E	Soins Aides - Soignantes	Commentary/Editorial| Commentaire/Éditorial
God’s spirit (Of wisdom) has been sent into the world, not covid-19: A contextual systematic-theological perspective	Veldsman,  DP	HTS Teologiese Studies / Theological Studies	Commentary/Editorial| Commentaire/Éditorial
Navigating the ethical Scylla and Charybdis of the COVID vaccine	Vercler,  C	Journal of pediatric rehabilitation medicine	Commentary/Editorial| Commentaire/Éditorial
Restitution of the NHS breast reconstruction service during the recovery phase of the Covid 19 pandemic	Vigneswaran,  P,  Clancy, et al	Journal of Plastic, Reconstructive and Aesthetic Surgery	Commentary/Editorial| Commentaire/Éditorial
Sex Differences in COVID-19: Candidate Pathways, Genetics of ACE2, and Sex Hormones	Viveiros,  A,  Rasmuson, et al	Am J Physiol Heart Circ Physiol	Commentary/Editorial| Commentaire/Éditorial
Adherence to Social Distancing Measures for Controlling COVID-19 Pandemic: Successful Lesson From Vietnam	Vo,  HL,  Nguyen, et al	Frontiers in Public Health	Commentary/Editorial| Commentaire/Éditorial
Crowding has consequences: Prevention and management of COVID-19 in informal urban settlements	von Seidlein,  L,  Alabaster, et al	Building and Environment	Commentary/Editorial| Commentaire/Éditorial
Lost Generations: Long-Term Effects of the COVID-19 Crisis on Job Losers and Labour Market Entrants, and Options for Policy*	von Wachter,  T	Fiscal Studies	Commentary/Editorial| Commentaire/Éditorial
COVID-19 - oral manifestations	Wadia,  R	British dental journal	Commentary/Editorial| Commentaire/Éditorial
Health, housing, and 'direct threats' during a pandemic	Wagner,  JK	Journal of Law and the Biosciences	Commentary/Editorial| Commentaire/Éditorial
Mitigating Health Risks to Reopen a Clinical Research Laboratory During the COVID-19 Pandemic: A Framework	Walker,  EM,  Jasper, et al	JMIR Res Protoc	Commentary/Editorial| Commentaire/Éditorial
Management strategies for diagnosis and treatment process of stroke patients during an outbreak of SARS-CoV-2	Wang,  D,  Jiang, et al	Journal of Xi'an Jiaotong University (Medical Sciences)	Commentary/Editorial| Commentaire/Éditorial
Characteristics of healthcare workers who died during the fight against COVID-19 in China	Wang,  Y,  Ji, et al	Pakistan Journal of Medical Sciences	Commentary/Editorial| Commentaire/Éditorial
From hostility to hospitality: Random thoughts on the impact of Covid-19	Weber,  S	Derrida Today	Commentary/Editorial| Commentaire/Éditorial
Smoking and COVID-19 - Did we overlook representativeness?	Wenzl,  T	Tobacco Induced Diseases	Commentary/Editorial| Commentaire/Éditorial
Review of article: Porfidia, A., Valeriani, E., Pola, R., Porreca, E., Rutjes, A.W.S., Di Nisio, M. Venous thromboembolism in patients with COVID-19: Systematic review and meta-analysis. Thrombosis Research. 2020;196:67–74	Whipple,  MO	Journal of Vascular Nursing	Commentary/Editorial| Commentaire/Éditorial
Letter to the Editor. The COVID-19 pandemic and the inequities of the neurosurgery match	White,  MD,  Fox, et al	J Neurosurg	Commentary/Editorial| Commentaire/Éditorial
Crown of spikes	Wills,  D	Derrida Today	Commentary/Editorial| Commentaire/Éditorial
Covid-19: Safety of lateral flow tests questioned after they are found to miss half of cases	Wise,  J	Bmj	Commentary/Editorial| Commentaire/Éditorial
Mobilizing a Whole Community: Policy and Strategy Implications of an Integrated Local System Response to a Global Health Crisis	Wojtak,  A,  Altenberg, et al	Healthcare quarterly (Toronto, Ont.)	Commentary/Editorial| Commentaire/Éditorial
Mandatory mask-wearing policy and universal anti-viral treatment mitigate influenza outbreaks during the COVID-19 pandemic	Wu,  HJ,  Ko, et al	Journal of Microbiology, Immunology and Infection	Commentary/Editorial| Commentaire/Éditorial
Military mental health and COVID-19	Wynn,  G,  Morganstein, et al	Journal of Military, Veteran and Family Health	Commentary/Editorial| Commentaire/Éditorial
Potential implications of SARS-CoV-2 oral infection in the host microbiota	Xiang,  Z,  Koo, et al	Journal of Oral Microbiology	Commentary/Editorial| Commentaire/Éditorial
Internet memes we live by (and die by)	Xie,  C	Internet Pragmatics	Commentary/Editorial| Commentaire/Éditorial
Why Chinese medicine works for COVID-19	Xu,  A	Journal of Traditional Chinese Medical Sciences	Commentary/Editorial| Commentaire/Éditorial
COVID-19, public attention and the stock market	Xu,  L,  Chen, et al	Accounting and Finance	Commentary/Editorial| Commentaire/Éditorial
Children wearing facemasks during the COVID-19 pandemic has reduced pressure on paediatric respiratory departments	Xu,  X	Acta Paediatrica, International Journal of Paediatrics	Commentary/Editorial| Commentaire/Éditorial
A Programmable Platform for Accelerating the Development of Smart Ultrasound Transducer Probe	Xu,  X,  Wala, et al	IEEE Trans Ultrason Ferroelectr Freq Control	Commentary/Editorial| Commentaire/Éditorial
Coronavirus Disease 2019 (COVID-19) Spread and Pharmacovigilance Implications: Expert Opinion	Yamoah,  P,  Alalbila, et al	Therapeutic Innovation and Regulatory Science	Commentary/Editorial| Commentaire/Éditorial
Management strategies for patients in the oncology radiotherapy department during an outbreak of novel coronavirus infection	Yang,  Y,  Sun, et al	Journal of Xi'an Jiaotong University (Medical Sciences)	Commentary/Editorial| Commentaire/Éditorial
High school students’ experience of online learning during Covid-19: the influence of technology and pedagogy	Yates,  A,  Starkey, et al	Technology, Pedagogy and Education	Commentary/Editorial| Commentaire/Éditorial
Whole community co-production: a full picture behind the successful COVID-19 response in S. Korea	Yeo,  J,  Lee, et al	Transforming Government: People, Process and Policy	Commentary/Editorial| Commentaire/Éditorial
Editorial: Proteins of SARS CoV-2, the Cause of COVID-19, and the Proteins that Interact with Them	Yoshimoto,  FK,  Berliner, et al	Protein J	Commentary/Editorial| Commentaire/Éditorial
How I survived COVID-19 shielding in the first wave	Young,  L	Emergency Nurse	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and impairment of spermatogenesis: Implications drawn from pathological alterations in testicles and seminal parameters	Zafar,  MI,  Li, et al	EClinicalMedicine	Commentary/Editorial| Commentaire/Éditorial
Whither Critical Management and Organization Studies? For a Performative Critique of Capitalist Flows in the Wake of the COVID-19 Pandemic	Zanoni,  P	Journal of Management Studies	Commentary/Editorial| Commentaire/Éditorial
Consent, decision-making and operative planning in plastic surgery during the COVID-19 pandemic	Zargaran,  A,  Zargaran, et al	Journal of Plastic, Reconstructive and Aesthetic Surgery	Commentary/Editorial| Commentaire/Éditorial
COVID-19: A unique opportunity to upgrade medical conferences	Zargaran,  D,  Zargaran, et al	Journal of Plastic, Reconstructive and Aesthetic Surgery	Commentary/Editorial| Commentaire/Éditorial
Ethics and Covid-19 in nursing homes, a return of experience	Zawieja,  P,  Benattar, et al	Soins Gerontologie	Commentary/Editorial| Commentaire/Éditorial
Sensitive, Rapid, Low-Cost, and Multiplexed COVID-19 Monitoring by the Wireless Telemedicine Platform	Zhang,  Z,  Tang, et al	Matter	Commentary/Editorial| Commentaire/Éditorial
Problems and strategies of protection during examination of patients with COVID-19 using the mobile CT in mobile cabin hospital	Zhao,  J,  Zheng, et al	Chinese Journal of Radiological Medicine and Protection	Commentary/Editorial| Commentaire/Éditorial
Letter in response to the article: Pros and cons for use of statins in 59 people with coronavirus disease-19 (COVID-19)(Ray, S et al.)	Zhao,  T,  Peng, et al	Diabetes and Metabolic Syndrome: Clinical Research and Reviews	Commentary/Editorial| Commentaire/Éditorial
Reconfigure rehabilitation services during the Covid-19 pandemic: best practices from Southwest China	Zhu,  S,  Zhang, et al	Disabil Rehabil	Commentary/Editorial| Commentaire/Éditorial
Coronavirus Disease 2019 and Vaccination of Children and Adolescents: Prospects and Challenges	Zimet,  GD,  Silverman, et al	Journal of Pediatrics	Commentary/Editorial| Commentaire/Éditorial
PMC7713544; Scientific Collaboration and Communication in the Time of COVID-19: A Chat with Christine Mummery		Cell Stem Cell	Commentary/Editorial| Commentaire/Éditorial
Correction: Impact of self-imposed prevention measures and short-term government-imposed social distancing on mitigating and delaying a COVID-19 epidemic: A modelling study		PLoS Med	Commentary/Editorial| Commentaire/Éditorial
Virtual reality for behavioral health workforce development in the era of COVID-19		Journal of substance abuse treatment	Commentary/Editorial| Commentaire/Éditorial
Reply to Moghnieh et al., COVID-19: Second Wave or Multiple Peaks, Natural Herd Immunity or Vaccine—We Should be Prepared		Disaster Medicine and Public Health Preparedness	Commentary/Editorial| Commentaire/Éditorial
Erratum: Correction: Access to primary healthcare during lockdown measures for COVID-19 in rural South Africa: an interrupted time series analysis (BMJ open (2020) 10 10 (e043763))		BMJ open	Commentary/Editorial| Commentaire/Éditorial
Erratum: Correction for Goldstein and Lee, Demographic perspectives on the mortality of COVID-19 and other epidemics (Proceedings of the National Academy of Sciences of the United States of America (2020) 117 36 (22035-22041))		Proceedings of the National Academy of Sciences of the United States of America	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and the rocket science of public health		MEDICC Review	Commentary/Editorial| Commentaire/Éditorial
Correction to Lancet Psychiatry 2020; published online Nov 9. https://doi.org/10.1016/S2215-0366(20)30462-4 (The Lancet Psychiatry, (S2215036620304624), (10.1016/S2215-0366(20)30462-4))		The Lancet Psychiatry	Commentary/Editorial| Commentaire/Éditorial
Corrigendum to: Obesity predisposes to the risk of higher mortality in young COVID‐19 patients (Journal of Medical Virology, (2020), 92, (2536-2542), 10.1002/jmv.26039)		Journal of medical virology	Commentary/Editorial| Commentaire/Éditorial
Coronavirus: Factors determining SARS-CoV-2 endemicity		Science	Commentary/Editorial| Commentaire/Éditorial
Krankenhausstudie 2020 - Covid-19 verschärft wirtschaftliche Situation deutscher Kliniken		Gesundheitsokonomie und Qualitatsmanagement	Commentary/Editorial| Commentaire/Éditorial
Psychosozialer Stress durch Covid-19 - Pflegepersonal in Deutschland fühlte sich zu Beginn der Pandemie psychisch stark belastet		Gesundheitsokonomie und Qualitatsmanagement	Commentary/Editorial| Commentaire/Éditorial
Erratum: Initial impacts of the COVID-19 pandemic on the Canadian La-bour market (Canadian Public Policy (2020) 46:S1 (S55-S65) DOI: 10.3138/cpp.2020-049)		Canadian Public Policy	Commentary/Editorial| Commentaire/Éditorial
Erratum: Resuming elective orthopaedic surgery during the CoviD-19 pandemic (J Bone Joint Surg AM (2020) 102:14 (1205-1212) DOI: 10.2106/JBJS.20.00844)		Journal of Bone and Joint Surgery - American Volume	Commentary/Editorial| Commentaire/Éditorial
Manufacturers Shift to PPE Production to Fight COVID-19 Pandemic		Assembly	Commentary/Editorial| Commentaire/Éditorial
Myocarditis in Multisystem Inflammatory Syndrome in Children Associated With Coronavirus Disease 2019: Erratum		Cardiol Rev	Commentary/Editorial| Commentaire/Éditorial
Erratum: Hydroxychloroquine with or without azithromycin in mild-to-moderate covid-19 (The New England Journal of Medicine DOI: 10.1056/nejmoa2019014)		New England Journal of Medicine	Commentary/Editorial| Commentaire/Éditorial

Appendix: Process and definitions. 

A daily search for new publications is conducted in PubMed, Scopus, BioRxiv and MedRxiv, SSRN, Research Square, arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2 OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database.  The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google.  Publishers include Lancet, Elsevier, The New England Journal of Medicine, BMJ, Wiley, Springer Nature, ChinaCDCweekly. Additionally the database is cross-referenced with other literature scans and activities by collaborators.  Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa Waddell for additional information: Lisa.Waddell@canada.ca.  References are compiled in a reworks database that has citations since the beginning of the outbreak.  All references can be accessed at this link and by the categories listed below.  The daily scan has also been compiled in an excel sheet and copies can be provided upon request or accessed here.

Category Definitions:

Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely to influence future results.

Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro, attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*

Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.

Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.* 

Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.

Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers. 

Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data.  Surveillance data will likely be number of cases suspected/confirmed, number of deaths, number recovered. *

Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses

Diagnostics / Pathogen detection:  All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.

Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.

Vaccine Research:  Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.

Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.

Public Health interventions*: Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).

Public Health response: Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.

Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC

Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to:  set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.

Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.

Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)

Animal Model: An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the added risk of harming an actual human.

Zoonotic: all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.

Review Literature:  All articles that summarize the published literature can be tagged as a review.  This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*

Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary category.

News articles that have not scientific information.

*Lists are not exhaustive

Annexe: Processus et définitions. 

Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus, BioRxiv and MedRxiv, SSRN, Research Square, arXiv pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV).  La saisie renvoie à des annonces de publication sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google.  Parmi les éditeurs figurent Lancet, Elsevier, The New England Journal of Medicine, BMJ, Wiley, Springer Nature, ChinaCDCweekly.  En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.  Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au : Lisa.Waddell@canada.ca.  Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie.  Toutes les références sont accessibles à partir de ce lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées ici.

Définitions des catégories :

Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats. Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.

Épidémiologie : Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque, le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.

Transmission : Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.

Données cliniques des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.* 

Séquelles à long terme: Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.

Santé mentale: Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.

Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.  Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *

Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.

Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes, etc.

Thérapeutique : Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.

Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.

Priorités de santé publique : Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.

Interventions de santé publique* : Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).

Réponse de la santé publique : Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées à la pandémie.

Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) : Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.

Réponse des soins de santé : Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment :  mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux / stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.

Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)

Modèle animal: Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.

Zoonotic: all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.

Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19

Revue de la documentation :  Tous les articles qui résument les documents publiés peuvent être marqués comme une revue.  Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.

Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.

journaux Articles de presse qui n'ont pas d'informations scientifiques.

* Les listes ne sont pas exhaustives