Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19,
2020-12-07
Good afternoon,
There are 565 citations in today’s scan. 304 were considered primary research or review literature.
Highlights today include:
CANADA
·
Fisman et al
used a public health case management data system to build and validate 4 accurate, well-calibrated, robust clinical prediction rules for COVID-19 mortality in Ontario, Canada. Age and comorbidities (notably diabetes, renal disease, and immune compromise)
were strong predictors of mortality.
·
Anderson et al introduce a Bayesian epidemiological model in which a proportion of individuals are
willing and able to participate in distancing, with the timing of distancing measures informed by survey data on attitudes to distancing and COVID-19. We fit our model to reported COVID-19 cases in British Columbia (BC), Canada, and five other jurisdictions.
We found that, distancing had a strong impact in BC, consistent with declines in reported cases and in hospitalization and intensive care unit numbers. Our projections indicate that intermittent distancing measures-if sufficiently strong and robustly followed-could
control COVID-19 transmission.
·
Manny et al.,
report on a longitudinal SARS-CoV-2 seropositivity study from Alberta Canada, the study found SARS-CoV-2 seropositivity in a the sample to be low. None reported a positive SARS-CoV-2 RT-PCR result prior to recruitment, nine children (1.6%) were likely
seropositive. Children who did not wear a mask (never, rarely, occasionally) had a 4.2% (5/118) prevalence of being likely seropositive versus 0.9% (4/423) likely seropositive for children who often or always wore their mask.
EPIDEMIOLOGY
·
Varasavsky et al. modelled longitudinal, self-reported data from users of the COVID Symptom Study app
in England between March 24, and Sept 29, 2020. A total of 2,873,726 users living in England signed up to use the app. The estimated incidence was 15,841 daily cases, a prevalence of 0.53%, and R(t) of 1.17. Geographically, 15 (75%) regions had highest
incidence. Self-reported data from mobile applications can provide an agile resource to inform policy makers during pandemic.
·
Socolovithc et al aimed to describe the clinical outcomes of critically ill COVID-19 patients and assess
the impact on the use of hospital resources and compare with critically ill medical patients without COVID-19. They conclude that COVID-19 patients required more hospital resources, including invasive and non-invasive ventilation, had a longer duration of
mechanical ventilation, and a more prolonged ICU and hospital length of stay
IMMUNOLOGY
·
Cavaliere et al
reports a case of a neonate showing the presence of blood specific IgG and the absence of IgM and negative nasopharyngeal swab. He was born from an asymptomatic SARS‐CoV‐2‐infected mother with positive IgG and IgM. The transplacental passage of specific
IgG antibodies from the affected mother to the unaffected fetus highlights neonatal passive immunity.
CLINICAL DATA
·
Al Maani et al.
discussed in this report a confirmed case of COVID-19 in a physician who was diagnosed previously with MERS-CoV infection. This case of mild human disease with the two zoonotic β-coronaviruses in the same host indicates that earlier infection did perhaps
provide some but not complete cross-protection against SARS-CoV-2.
DIAGNOSTICS
·
Pahar et al
present a machine learning based COVID-19 cough classifier which is able to discriminate COVID-19 positive coughs from both COVID-19 negative and healthy coughs recorded on a smartphone. This type of screening is non-contact and easily applied, and could
help reduce workload in testing centers as well as limit transmission by recommending early self-isolation to those who have a cough suggestive of COVID-19. Our results show that the Resnet50 classifier was best able to discriminate between the COVID-19 positive
and the healthy coughs with an area under the ROC curve (AUC) of 0.98 while a LSTM classifier was best able to discriminate between the COVID-19 positive and COVID-19 negative coughs with an AUC of 0.94.
THERAPEUTICS
·
Cannon et al
tested the in vitro effectiveness of xylitol found in nasal spray against SARS-CoV-2. After a 25-minute contact time, the nasal spray reduced virus from 4.2 to 1.7 log10 CCID50 per 0.1 mL.
PUBLIC HEALTH RESPONSE
·
Lyu et al.
used more than 40,000 tweets posted by over 20,000 distinct Twitter users to capture public opinions on the potential vaccines for SARS-CoV-2. A lower acceptance level for the potential COVID-19 vaccines was observed among the socioeconomically disadvantaged
groups. The authors found that the U.S. public is most concerned about the safety, effectiveness, and political issues regarding the potential vaccines for COVID-19. The authors found that there are proportionally more religious people in the anti-vaccine
group.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley Otten, Drew
Greydanus, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark, Catherine Card, Ruey Su, Paul McLaren
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics /
Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance,
Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, Immunologie,
économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
|
PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Simulating infection transmission: A case study of COVID-19 |
Abadeer, M, Gorlatch, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions
de santé publique |
we introduce a new infection transmission model and examine protective measures as intervention options. We calibrate
and apply our model to simulate the COVID-19 epidemic situation in the city of Muenster, Germany. We implement our model on top of various locomotion models in the Vadere simulation framework. Experiments with our approach show that social distancing can reduce
the peak attack rates by up to 85%, while self-isolation or household quarantine can have a significant impact by delaying the epidemic peak. Furthermore, combining social distancing, self-quarantine and school closures can greatly mitigate the spread of the
epidemic. |
|
Abd Samat, AH, Isa, et al |
Annals of the Academy of Medicine, Singapore |
Healthcare Response | Réponse des soins de santé |
This study aims to evaluate the knowledge and confidence of emergency healthcare workers (EHCW) in facing the COVID-19 pandemic. A cross-sectional online
study using a validated questionnaire was distributed to 135 doctors (MD), assistant medical officers (AMO), and staff nurses (SN) at an urban tertiary Emergency Department. 68.9% (n = 93) had high knowledge while 53.3% (n = 72) possessed high confidence level.
Overall knowledge mean score was 32.96/40 (SD = 3.63) between MD (33.88±3.09), AMO (32.28±4.03), and SN (32.00±3.60), P= 0.025. EHCWs with a length of service (LOS) between 4-10 years had the highest knowledge compared to those with LOS <4-year (33.71±3.39
versus 31.21±3.19 P = 0.002). Airway-related knowledge was significantly different between the designations and LOS (P = 0.002 and P = 0.003, respectively). Overall, EHCW confidence level against LOS showed significant difference F (2, 132) = 5.46, P = 0.005]
with longer LOS showing better confidence. MD showed the highest confidence compared to AMO and SN (3.67±0.69, 3.53±0.68, 3.26±0.64) P = 0.049. The majority EHCW were confident in performing high-quality chest-compression, and handling of PPE but less than
half were confident in resuscitating, leading the resuscitation, managing the airway or being successful in first intubation attempt. |
|
|
Aini, Q |
European Journal of Molecular and Clinical Medicine |
Mental Health |
|
An online survey was conducted to describe the impact of the COVID-19 pandemic on people's behaviour and knowledge in Indonesia. This survey was carried
out from 5-10 May 2020, with 556 respondents of at least 17 years old, and it extended to various regions in almost all the provinces. Fifteen behaviors were studied, including COVID-19 knowledge, activities during the pandemic, anxiety levels, people's perception,
and habit changes during the pandemic. |
|
|
Akour, A, Al-Tammemi, et al |
Am J Trop Med Hyg |
Mental Health |
|
Our study aimed at assessing 1) psychological status, 2) challenges of distance teaching, and 3) coping activities and pandemic-related concerns among
university teachers in Jordan in the midst of COVID-19-related quarantine and control measures. Three hundred eighty-two university teachers returned completed surveys. Results of K10 showed that 31.4% of respondents had severe distress and 38.2% had mild
to moderate distress. Whereas gender was not associated with distress severity, age had a weak negative correlation (Rho = -0.19, P < 0.0001). Interestingly, most teachers had moderate to high motivation for distance teaching. Engagement with family was the
most reported self-coping activity. More than half of the participants were most concerned and fearful about SARS-CoV-2 infection. |
|
|
Albuquerque, Rosane Maria de, Da Silva, et al |
bioRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
In this work, 18 sequences of the SARS-CoV-2 virus were used, from four Brazilian states with 09, 04, 04, 8 and 01 haplotypes, respectively, with lengths
ranging from 234 to 29,903 bp. Of the 301 sites analyzed, 68% varied, 131 of which were parsimonium-informative sites. Phylogenetic analyses revealed the presence of two distinct subgroups, corroborated by the high FST (80%). The high degree of polymorphism
found among these samples helped to establish a clear pattern of non-genetic structuring, based on the time of divergence between the groups. All molecular variance estimators confirmed that there was no consensus in the conservation of the studied sequences,
also indicating a high variation for the protein products of the virus. |
|
|
Media and communal guidance: An analytical study of corona-campaigns |
Alfauzan, AH, Shariq, et al |
Asian ESP Journal |
Public Health response| Interventions de santé publique |
The purpose of this paper is to interpret the range of challenges that the outbreak of COVID-19 has presented as depicted
on the social media. Our objective is to meticulously analyze the impact of the media as an agent of social awareness in a circumstance as special as a pandemic. The study concludes that the extent of the awareness of the Saudi people as to the loaded language
used in the different media outlets is reasonably good, as they realise that the media may sometimes employ unfair language in order to increase their TRPs or ratings amongst the viewers. |
|
Alhuzimi, T |
Res Dev Disabil |
Mental Health | |
This study investigated the stress and emotional well-being of parents of children with ASD in Saudi Arabia during
the COVID-19 pandemic. The study obtained quantitative data from 150 parents of children with ASD from different regions in Saudi Arabia using an online survey. The study found that family ASD status (in particular, age and gender of child with ASD, and severity
of his/her symptoms) had a significant impact on parental stress and emotional well-being. Moreover, parental stress and emotional well-being were negatively impacted by the frequency and usefulness of ASD support received during COVID-19 pandemic. These were
also adversely impacted by the change in severity of ASD behaviours of the children with ASD. Finally, parental stress was found to have a negative impact on the emotional well-being of parents. Overall, the study found that the parental stress and emotional
well-being of parents of children with ASD in Saudi Arabia had been unfavourably impacted by COVID-19 pandemic. |
|
|
Facebook
translation service (FTS) usage among jordanians during COVID-19 lockdown |
Almahasees, Z, Jaccomard, et al |
Advances in Science, Technology and Engineering Systems |
Public Health response| Interventions de santé publique |
The study aimed to elicit information about assessing the use of Facebook translation service (FTS) as a source of
information in general and on COVID-19, in particular, FTS for those interested in English posts. The study found that 94.3% use Facebook daily; 87.1% of the participants activated FTS. It is found that 62.2% of the participants considered Facebook as a primary
source of information regarding COVID-19 and 27.8% as secondary source. In terms of FTS usage, 87.3% used FTS in translating English Facebook posts into Arabic, and 83.8% used FTS in translating English Facebook COVID-19 posts into Arabic during the lockdown.
Such research would encourage government officials to better use Facebook and FTS as complements to their national health campaigns. |
|
Mathematical modeling for novel coronavirus (COVID-19) and control |
Alqarni, MS, Alghamdi, et al |
Numerical Methods for Partial Differential Equations |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
We construct a new mathematical for the transmission dynamics of COVID-19 using the cases reported in Kingdom of Saudi
Arabia for March 02 till July 31, 2020. We investigate the parameters values of the model using the least square curve fitting and the basic reproduction number is suggested for the given data is
ℛ0 ≈ 1.2937. The stability results of the model are shown
when the basic reproduction number is ℛ0 < 1. The model
is locally asymptotically stable when ℛ0 < 1. Further, we
show some important parameters that are more sensitive to the basic reproduction number
ℛ0 using the PRCC method. The sensitive parameters that act
as a control parameters that can reduce and control the infection in the population are shown graphically. The suggested control parameters can reduce dramatically the infection in the Kingdom of Saudi Arabia if the proper attention is paid to the suggested
controls. |
|
Alsafi, MA, Hughes, et al |
Acta Crystallogr C Struct Chem |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The first example of molecular docking of the SARS-CoV-2 main protease for COVID-19 M(pro), Protein Data Bank (PDB)
code 7BQY] by a chalcone-based ligand, namely, (E)-1-(2,4-dichlorophenyl)-3-4-(morpholin-4-yl)phenyl]prop-2-en-1-one, C(19)H(17)Cl(2)NO(2), I, is presented. The binding affinity of our chalcone ligand with 7BQY is -7.0 kcal mol(-1), a high value which was
attributed to the presence of a hydrogen bond, together with many hydrophobic interactions between the drug and the active amino acid residues of the receptor. Docking studies were also performed, employing rigid and flexible binding modes for the ligand.
The superposition of N3 and the chalcone docked into the binding pocket of 7BQY is also presented. The synthesis, single-crystal structure, Hirshfeld surface analysis (HSA) and spectral characterization of heterocyclic chalcone-based compound I, are also presented.
The molecules are stacked, with normal π-π interactions, in the crystal. |
|
|
Quantifying the impact of COVID-19 control measures using a Bayesian model of physical distancing |
Anderson, SC, Edwards, et al |
PLoS Comput Biol |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission
Public health interventions*| Interventions de sant&eacute; publique |
We introduce a Bayesian epidemiological model in which a proportion of individuals are willing and able to participate
in distancing, with the timing of distancing measures informed by survey data on attitudes to distancing and COVID-19. We fit our model to reported COVID-19 cases in British Columbia (BC), Canada, and five other jurisdictions, using an observation model that
accounts for both underestimation and the delay between symptom onset and reporting. We found that, as of April 11 2020, distancing had a strong impact in BC, consistent with declines in reported cases and in hospitalization and intensive care unit numbers;
individuals practising physical distancing experienced approximately 0.22 (0.11-0.34 90% CI credible interval]) of their normal contact rate. The threshold above which prevalence was expected to grow was 0.55. We found that BC, New Zealand, and New York may
have had more room to relax distancing measures than the other jurisdictions, though this would need to be done cautiously and with total case volumes in mind. Our projections indicate that intermittent distancing measures-if sufficiently strong and robustly
followed-could control COVID-19 transmission. |
|
Anft, M, Paniskaki, et al |
Mol Ther |
Clinical data| Données cliniques Immunology | Immunologie |
To identify predictive markers of COVID-19 progress and outcome, we analyzed peripheral blood of 10 COVID-19-associated
ARDS patients and 35 mild/moderate COVID-19 patients, not requiring intensive care. ARDS patients demonstrated significantly higher S-protein-reactive CD4(+) and CD8(+) T cells compared to non-ARDS patients. Comparison of circulating bulk T cells in ARDS patients
to non-ARDS patients demonstrated decreased frequencies of CD4(+) and CD8(+) T cell subsets, with activated memory/effector T cells expressing tissue migration molecule CD11a(+)(+). Survival from ARDS (4/10) was accompanied by a recovery of the CD11a(+)(+)
T cell subsets in peripheral blood. Conclusively, data on S-protein-reactive polyfunctional T cells indicate the ability of ARDS patients to generate antiviral protection. Furthermore, decreased frequencies of activated memory/effector T cells expressing tissue
migratory molecule CD11a(+)(+) observed in circulation of ARDS patients might suggest their involvement in ARDS development and propose the CD11a-based immune signature as a possible prognostic marker. |
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|
Arino, Julien, Bajeux, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique |
Using a stochastic model, we assess the risk of importation-induced local transmission chains in locations seeing few
or no local transmissions and evaluate the role of quarantine in the mitigation of this risk. We find that the rate of importations plays a critical role in determining the risk that case importations lead to local transmission chains, more so than local transmission
characteristics, i.e., strength of social distancing measures (NPI). A high level of compliance with post-arrival quarantine followed by testing achieves this objective with less of an impact than travel restrictions or bans. |
|
|
Asadian, S, Hosseini, et al |
Clinical Case Reports |
Clinical data| Données cliniques |
Describe two case reports where COVID-19 affects the heart through various pathways. It can increase thrombotic complications
that ultimately lead to myocardial infarction even in patients without a history of underlying heart disease. |
|
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Non-Receptor-Mediated Lipid Membrane Permeabilization by the SARS-CoV-2 Spike Protein S1 Subunit |
Asandei, A, Mereuta, et al |
ACS Appl Mater Interfaces |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Through electrophysiology and fluorescence spectroscopy experiments, we show that even in the absence of the angiotensin-converting
enzyme 2 receptor, the S1 subunit from SARS-CoV-2 spike protein binding to neutral phospholipid membranes leads to their mechanical destabilization and permeabilization. A similar cytotoxic effect of the protein was seen in human lung epithelial cells. A monoclonal
antibody generated toward the S1 subunit alleviates to a considerable extent the destabilizing potential of the protein in such model membranes. Finally, we demonstrate the proof-of-concept capability of an α-hemolysin (α-HL) protein nanopore to detect in
aqueous buffer and real time the region-binding domain of the S1 subunit from SARS-CoV-2 spike protein by monitoring its immunological interaction with a target antibody. Our results may offer new perspectives in understanding the pathogenesis of the SARS-CoV-2
infection, its treatment, and real-time detection. |
|
Neurosurgical education during COVID-19: challenges and lessons learned in Egypt |
Ashry, AH, Soffar, et al |
Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
Mental Health |
|
The aim of this cross-sectional study was the evaluation of the impact of COVID-19 on neurosurgical residency programs
and neurosurgical practice in five tertiary medical centers in Egypt. Fifty residents responded to our survey. We identified a significant reduction in surgical cases, inpatient services, and working hours per week during the pandemic comparing to the pre-pandemic
era. We also identified a significant increase in research hours and changes in educational methods from in-person methods to virtual ones. Seventy-four percent reported that personal protective equipment was not adequate for their duties. Sixty-eight percent
experienced burnout symptoms. Unavailability of personal protective equipment, negative concerns regarding the surgical career, and financial strains significantly affected the mental health of residents. |
|
Avery, AR, Tsang, et al |
Frontiers in Psychiatry |
Mental Health |
|
The objective of this study was to examine if stress and anxiety were associated with changes in alcohol use in a sample
of adult twins. Twins allowed us to control for genetic and shared environmental factors that would confound the alcohol - mental health relationship. Twins (N = 3,971; 909 same-sex pairs) from the Washington State Twin Registry (WSTR) completed an online
survey examining several health-related behaviors and outcomes and their self-reported changes due to COVID-19. About 14% of the respondents reported an increase in alcohol use. We found an association between both stress and anxiety and increased alcohol
use, where twins with higher levels of stress and anxiety were more likely to report an increase in alcohol consumption. The associations were small and confounded by between-family factors and demographic characteristics. However, there was no significant
difference in stress or anxiety levels between non-drinkers and those who reported no change in alcohol use. Our findings suggest that individuals’ mental health may be associated with changes in alcohol use during the COVID-19 pandemic. |
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Ayerdi, O, Puerta, et al |
Open Forum Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
An observational descriptive study of the seroprevalence of antibodies for SARS-CoV-2 among men who have sex with men
and transgender women without use of PrEP (Group 1; n = 250) and PrEP users with disoproxil fumarate/tenofovir/emtricitabine (TDF/FTC) (n = 409) or tenofovir alafenamide (TAF)/FTC (n = 91) (Group 2; n = 500) was conducted from May11, 2020 to June 27, 2020.
The seroprevalence of SARS-CoV-2 was 9.2% (95% CI: 5.9–13.5) in the group without PrEP and 15.0% (95% CI, 12.0–18.4) in the group with PrEP (P = .026). Among users of TDF/FTC it was 14.7% (95% CI, 11.4–18.5), and in users of TAF/FTC it was 16.5% (95% CI, 9.5–25.7)
(P = .661). In those who tested positive for SARS-CoV-2 and receiving PrEP, 57.4% manifested symptoms, compared with 78.3% in the control group (P = .070). In users of TDF/FTC the figure was 53.3% and in users of TAF/FTC the figure was 73.3% (P = .100). The
duration of symptoms was 11.5 days in the control group, 9.0 days in PrEP users (P = .116), 7.0 days in users of TDF/FTC, and 13.0 days in users of TAF/FTC (P = .100). |
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Drugs4Covid: Drug-driven Knowledge Exploitation based on Scientific Publications |
Badenes-Olmedo, Carlos, Chaves-Fraga, et al |
arXiv |
Therapeutics| Thérapeutique |
Drugs4Covid combines word embedding techniques and semantic web technologies to enable a drug-oriented exploration
of large medical literature. Drugs and diseases are identified according to the ATC classification and MeSH categories respectively. More than 60K articles and 2M paragraphs have been processed from the CORD-19 corpus with information of COVID-19, SARS, and
other related coronaviruses. An open catalogue of drugs has been created and results are publicly available through a drug browser, a keyword-guided text explorer, and a knowledge graph. |
|
Baghaei, P, Nadji, et al |
Tanaffos |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we aimed to determine the clinical manifestations and outcomes of the first confirmed cases of COVID-19
infection in Iran (n=127). Of 412 suspected cases, with the mean age of 54.1 years (SD=13.4), 127 (31%) were positive for COVID-19. Following the patients’ first visit to the clinic, 115 cases were admitted to the general ward, while ten patients required
ICU admission. Due to clinical deterioration in the condition of 25 patients (out of 115 patients), ICU admission was essential. Based on the results, the baseline characteristics of the groups were similar. Patients requiring ICU admission were more likely
to have multiorgan involvement (liver involvement, P<0.001; renal involvement, P<0.001; and cardiac involvement, P=0.02), low O2 saturation (P<0.001), and lymphopenia (P=0.05). During hospital admission, 21 (16.5%) patients died, while the rest (83.5%) were
discharged and followed-up until March 26, 2020. Also, the survival rate of patients, who received immunoglobulin, was higher than other patients (60.87% vs. 39.13%). |
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Ballesteros Reviriego, G, Planas Pascual, et al |
Topics in Geriatric Rehabilitation |
Clinical data| Données cliniques |
This article discusses a 38-year-old woman admitted to the ICU for acute respiratory failure secondary to SARS-CoV-2
infection. Early physiotherapy improved lung secretion removal, respiratory mechanics outcomes, gas exchange, and muscle strength without adverse effects. |
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A Distinct Phylogenetic Cluster of Indian Severe Acute Respiratory Syndrome Coronavirus 2 Isolates |
Banu, S, Jolly, et al |
Open Forum Infectious Diseases |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
We performed whole-genome sequencing of 303 Indian SARS-CoV-2 isolates, and we analyzed them in the context of publicly
available data from India. We describe a distinct phylogenetic cluster (Clade I/A3i) of SARS-CoV-2 genomes from India, which encompasses 22% of all genomes deposited in the public domain from India. Globally, approximately 2% of genomes, which to date could
not be mapped to any distinct known cluster, fall within this clade. The cluster is characterized by a core set of 4 genetic variants and has a nucleotide substitution rate of 1.1 × 10–3 variants per site per year, which is lower than the prevalent A2a cluster.
Epidemiological assessments suggest that the common ancestor emerged at the end of January 2020 and possibly resulted in an outbreak followed by countrywide spread. To the best of our knowledge, this is the first comprehensive study characterizing this cluster
of SARS-CoV-2 in India. |
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Transcriptional response modules characterise IL-1β and IL-6 activity
in COVID-19 |
Bell, LucyCK, Meydan, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
We show that the expression of IL-1β or IL-6 inducible transcriptional signatures (modules) reflects the bioactivity
of these cytokines in immunopathology modelled by juvenile idiopathic arthritis (JIA) and rheumatoid arthritis. In COVID-19, elevated expression of IL-1β and IL-6 response modules, but not the cytokine transcripts themselves, is a feature of infection in the
nasopharynx and blood, but is not associated with severity of COVID-19 disease, length of stay or mortality. We propose that IL-1β and IL-6 transcriptional response modules provide a dynamic readout of functional cytokine activity in vivo, aiding quantification
of the biological effects of immunomodulatory therapies in COVID-19. |
|
Bertoglio, Federico, Fühner, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins Immunology | Immunologie |
In this study antibody gene libraries from convalescent COVID-19 patients were constructed.Recombinant antibody fragments
(scFv) against the receptor binding domain (RBD) of the S1 subunit of the viral spike (S) protein were selected by phage display. In contrast to other published anti-SARS-CoV-2 antibodies, the binding of STE90-C11 is not blocked by known RBD mutations, endowing
our antibody with higher intrinsic resistance to those possible escape mutants. |
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Assaying Large-scale Testing Models to Interpret Covid-19 Case Numbers. A Cross-country Study |
Besserve, Michel, Buchholz, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
The number of reported cases may be influenced by multiple factors, notably depending on the public policy regarding
testing. Absolute case numbers proved to be a poor predictor of prevalence. Models accounting for testing capacity, limiting the pool of tested individuals, produced better prevalence estimates used to predict SARS-CoV-2-attributed death rate trajectories. |
|
Bhandari, S, Shaktawat, et al |
Annals of Thoracic Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A retrospective observational descriptive study was conducted on 29 COVID-19 patients admitted at a premier medical
institution of North India in the months of February and March 2020. Demographic, clinical, and laboratory data were collected. Symptoms included fever (48%), cough (31%), and shortness of breath (17%). |
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Bhatia, K, Columb, et al |
Anaesthesia |
Healthcare Response | Réponse des soins de santé |
We explored whether general anaesthesia rates for caesarean section changed during the peak of the pandemic across
six maternity units in the north-west of England. A significant reduction (7.7 to 3.7%, p < 0.0001) in general anaesthetic rates, risk ratio (95%CI) 0.50 (0.39–0.93), was noted across hospitals during the pandemic. |
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Blaivas, M |
J Ultrasound Med |
Long-Term Sequelae |
|
Determining the cause of the lingering effects of COVID-19, such as cardiac and pulmonary impacts can be difficult
due to the clearance of the virus SARS-CoV-2. |
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Blanco, Víctor, Gázquez, et al |
arXiv |
Healthcare Response | Réponse des soins de santé |
In this paper we provide a mathematical programming based decision tool to optimally reallocate and share equipments
between different units in emergency situations under lack of resources. The approach is motivated by the COVID-19 pandemic in which many Heath National Systems were not able to satisfy the demand of ventilators, sanitary individual protection equipments or
different human resources. |
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Searching for COVID-19 Antibodies in Czech Children—A Needle in the Haystack |
Bloomfield, M, Pospisilova, et al |
Frontiers in Pediatrics |
Epidemiology| Épidémiologie Immunology | Immunologie |
As infected children often exhibit mild symptoms or even remain asymptomatic, they are likely to be under tested for
the direct presence of the virus. August, 2020, we screened 200 children (0–18 years of age), who attended the pediatric department of a large hospital in Prague for various COVID-19-unrelated reasons, for the presence of SARS-CoV-2 antibodies. Zero seropositive
subjects were found indicating low (<0.5%) seroprevalence amongst children in Prague. |
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The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer
outcome |
Blot, M, Bour, et al |
J Transl Med |
Clinical data| Données cliniques Immunology | Immunologie |
A comparison of COVID-19 patients and non-COVID-19 patients requiring mechanical ventilation. We identified a unique
cytokine response, with higher plasma GM-CSF and CXCL10 in COVID-19 patients that were independently associated with the longer duration of mechanical ventilation. |
|
Borillo, GA, Kagan, et al |
Open Forum Infectious Diseases |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Pooled and individual testing of specimens positive for SARS-CoV-2 demonstrated 100% agreement, which demonstrates
the viability of pooled specimens for SARS-COV-2 testing using a dual-target RT-PCR system. |
|
|
Bouzid, D, Mullaert, et al |
PLoS One |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
A prospective cohort including all consecutive patients admitted through the emergency department’s (ED) and presenting
respiratory symptoms from November 2019 to April 2020. Simple discrimination of strong SARS-CoV-2 suspicion with a limited set of clinical features seems possible but will not eliminate the need for rapid PCR assays. |
|
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Bramante, CarolynT, Ingraham, et al |
The Lancet Healthy Longevity |
Therapeutics| Thérapeutique |
Our aim was to identify whether metformin reduced COVID-19-related mortality and whether sex-specific interactions
exist.Metformin was significantly associated with reduced mortality in women with obesity or type 2 diabetes who were admitted to hospital for COVID-19. |
|
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Bray, RA, Lee, et al |
Transplantation |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study describes the development and validation of a high throughput multiplex antibody detection assay. : The
multiplex assay has the capacity to identify, simultaneously, patient responses to 5 SARS-CoV-2 proteins, namely, the full spike protein, 3 individual domains of the spike protein (S1, S2 and receptor binding domain) and the nucleocapsid protein. The antibody
response to the above proteins are SARS-CoV-2 specific, as antibodies against 4 common coronaviruses do not cross-react. |
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|
Bricker, Traci, Darling, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins Animal model | Modèle animal |
In this study they compared the protective capacity of intranasal and intramuscular delivery of a chimpanzee adenovirus-vectored
vaccine encoding a pre-fusion stabilized spike protein in Golden Syrian hamsters. Antibody levels in serum were higher in hamsters immunized by an intranasal compared to intramuscular route. Intranasal immunization with ChAd-SARS-CoV-2-S provided superior
protection against SARS-CoV-2 infection and inflammation in the upper respiratory tract. |
|
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Comparing the performance of ResNets on COVID-19 diagnosis using CT scans |
Cai, X, Wang, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
ResNet, short for Residual Networks is a classic neural network used as a backbone for many computer vision tasks.
Using this technology to aids the analysis of CT scans increasing their diagnostic utility. |
|
Çakır, B, Okuyan, et al |
Eur J Pharmacol |
Therapeutics| Thérapeutique |
In this study, peptides derived from beta-lactoglobulin, which inactivates both the virus and its receptors in the
host cell, were identified using computer-based in silico analysis. The beta-lactoglobulin derived peptides used in this study were obtained by the treatment of goat milk whey fraction with trypsin. The structure of the peptides was characterized by the liquid
chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS), and six beta-lactoglobulin derived peptides were selected as candidate peptides. Subsequently, the effects of peptides on SARS-CoV-2 and host cells were identified using virtual screening.
According to the results of this in silico analysis, Ala-Leu-Pro-Met-His-Ile-Arg (ALMPHIR) and Ile-Pro-Ala-Val-Phe-Lys (IPAVFK) peptides were evaluated as potential candidates to be used in the treatment of SARS-CoV-2 after the future in vitro and in vivo
studies. |
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Campo, G, Contoli, et al |
Platelets |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study investigated the relationship between platelet activation, myocardial injury, and mortality in patients
affected by Coronavirus disease 2019 (COVID-19). Fifty-four patients with respiratory failure due to SARS-CoV-2 infection were included. Eleven patients with the same clinical presentation, but negative for SARS-CoV-2 infection, were included as controls.
Platelet biomarkers did not differ between cases and controls, except for sCD40L which was higher in COVID-19 patients (p = .003). In COVID-19 patients, P-selectin and sCD40L levels decreased from T1 to T3 and were higher in cases requiring admission to intensive
care unit (p = .004 and p = .008, respectively). Patients with myocardial injury (37%), as well as those who died (30%), had higher values of all biomarkers of platelet activation (p < .05 for all). Myocardial injury was an independent predictor of mortality. |
|
|
In Vitro Analysis of the Anti-viral Potential of nasal spray constituents
against SARS-CoV-2 |
Cannon, MarkL, Westover, et al |
bioRxiv |
Therapeutics| Thérapeutique |
This study tested the effectiveness of xylitol against SARS-CoV-2. Virus titers and LRV of SARS-CoV-2, were incubated
with a single concentration of nasal spray. Toxicity was observed in the top dilution (1/10). Virus was seen below that dilution so it did not affect calculations of virus titer or LRV. After a 25-minute contact time, the nasal spray reduced virus from 4.2
to 1.7 log10 CCID50 per 0.1 mL, a statistically significant reduction of 2.5 log10 CCID50. STEM Images obtained at the BIoCryo Laboratory revealed virus contained on the cell wall but none intra-cellular, possibly due to D-xylose (xylitol) production of glycoaminoglycans
decoy targets. |
|
Cano-Pérez, E, Torres-Pacheco, et al |
Am J Trop Med Hyg |
Epidemiology| Épidémiologie |
This study investigated the relationship between altitude and the COVID-19 pandemic in Colombia. Analyzed data from
70 cities with altitudes between 1 and 3,180 m. Correlations and linear regression models adjusted to population density were performed to examine the relationship and contribution of altitude to epidemiological variables. The case fatality rate was negatively
correlated with the altitude of the cities. The incidence of cases and deaths from COVID-19 had an apparent correlation with altitude; however, these variables were better explained by population density. In general, these findings suggest that living at high
altitude can reduce the impact of COVID-19, especially the case fatality rate. |
|
|
Cardozo, KHM, Lebkuchen, et al |
Nat Commun |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study developed a high-throughput targeted proteomics assay to detect SARS-CoV-2 nucleoprotein peptides directly
from nasopharyngeal and oropharyngeal swabs. A modified magnetic particle-based proteomics approach implemented on a robotic liquid handler enables fully automated preparation of 96 samples within 4 hours. A TFC-MS system allows multiplexed analysis of 4 samples
within 10 min, enabling the processing of more than 500 samples per day. Validated this method qualitatively (Tier 3) and quantitatively (Tier 1) using 985 specimens previously analyzed by real-time RT-PCR, and detect up to 84% of the positive cases with up
to 97% specificity. |
|
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Cavaliere, AF, Marchi, et al |
Journal of medical virology |
Transmission Clinical data| Données cliniques Immunology | Immunologie |
This report presents a case of a neonate showing the presence of blood specific IgG and the absence of IgM and negative
nasopharyngeal swab. He was born from an asymptomatic SARS-CoV-2-infected mother with positive IgG and IgM. The transplacental passage of specific IgG antibodies from the affected mother to the unaffected fetus highlights neonatal passive immunity. |
|
|
Cento, V, Alteri, et al |
PLoS ONE |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique Immunology | Immunologie |
This study evaluated the effectiveness of two months of lockdown and two of surveillance through a hospital-based SARS-CoV-2
molecular and serological screening in Milan, during March-April 2020. The cumulative anti-N IgG seroprevalence in the 2753 subjects analyzed was of 5.1% (95%CI = 4.3%-6.0%), with a peak of 8.4% (6.1%-11.4%) 60–63 days since the peak of diagnoses (March-20).
31/106 (29.2%) anti-N reactive subjects had anti-S1/S2 titers >80 AU/mL. Being tested from May-18 to June-5, or residing in the provinces with higher SARS-CoV-2 circulation, were positively and independently associated with anti-N IgG reactivity (OR 95%CI]:
2.1791.455–3.264] and 3.1271.18–8.29], respectively). In the 18 RT-PCR positive, symptomatic subjects, anti-N seroprevalence was 33.3% (95% CI: 14.8%-56.3%). |
|
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Chan, JF, Zhang, et al |
Clin Infect Dis |
Transmission Animal model | Modèle animal |
This animal model study tested the golden Syrian hamster to examine the virus challenge, contact transmission, and
passive immunoprophylaxis. Maximal clinical signs of rapid breathing, weight loss, histopathological changes from the initial exudative phase of diffuse alveolar damage with extensive apoptosis to the later proliferative phase of tissue repair, airway and
intestinal involvement with viral nucleocapsid protein expression, high lung viral load, and spleen and lymphoid atrophy associated with marked chemokine/cytokine activation were observed within the first week of virus challenge. The mean lung virus titer
was between 105 and 107 TCID50/g. Challenged index hamsters consistently infected naive contact hamsters housed within the same cages, resulting in similar pathology but not weight loss. All infected hamsters recovered and developed mean serum neutralizing
antibody titers ≥1:427 14 days postchallenge. Immunoprophylaxis with early convalescent serum achieved significant decrease in lung viral load but not in lung pathology. No consistent nonsynonymous adaptive mutation of the spike was found in viruses isolated
from the infected hamsters. |
|
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[Nursing Experience Caring for a COVID-19 Patient With Hearing Loss] |
Chen, CH, Pan, et al |
Hu Li Za Zhi |
Clinical data| Données cliniques |
The article presents the case management of a male patient with hearing loss who was diagnosed with COVID-19 after
returning to Taiwan from overseas. During the nursing care process, the author helped the patient receive the antiviral treatment and taught him how to do diaphragmatic breathing in a comfortable, recumbent position to improve his breathing pattern. To reduce
the difficulty of communication, the author made a pile of cards with common care-related words, provided pen and paper to write, and used a mobile-phone-based social-networking application to communicate with the patient. The author used writing to communicate
with the patient and learned some simple signs from him to enable interaction. Moreover, the intervention helped him adapt to the isolation and treatment protocols to reach holistic nursing care. |
|
Chen, Chiung-Ya, Chou, et al |
bioRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
This study shows that expression of both D614 and G614 spike proteins is sufficient to induce phenotypes of impaired
neuronal morphology, including defective dendritic spines and shortened dendritic length. Using spike protein-specific monoclonal antibodies, the authors found that D614 and G614 spike proteins show differential S1/S2 cleavage and cell fusion efficiency. The
findings provide an explanation for higher transmission of the G614 variant and the neurological manifestations observed in COVID-19 patients. |
|
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Chen, R, Yu, et al |
Frontiers in Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In a single-center and retrospective cohort study, the outcomes in COVID-19 patients with or without GI symptoms were
compared. Among 1,113 eligible patients, 359 patients with GI symptoms and 718 without GI symptoms had similar propensity scores and were included in the analyses. Patients with GI symptoms, as compared with those without GI symptoms, were associated with
a similar risk of death, but with higher risks of ARDS, non-invasive mechanical ventilation in COVID-19 patients, respectively. |
|
|
Chen, S, Chen, et al |
J Travel Med |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique Healthcare Response | Réponse des soins de santé |
This study examined the impact of facility-based isolation compared to self-isolation at home on the continuing epidemic
in the United States. Projected that facility-based isolation with moderate capacity of 5 beds per 10 000 total population could avert 4.17 (95% Credible Interval 1.65-7.11) million new infections and 16 000 (8000-23 000) deaths in two months compared with
home-based isolation, equivalent to relative reductions of 57% (44-61%) in new infections and 37% (27-40%) in deaths. Facility-based isolation with high capacity of 10 beds per 10 000 population would achieve greater reduction of 76% (62-84%) in new infections
and 52% (37-64%) in deaths when supported by the expanded testing with a 20% daily diagnosis rate. Delays in implementation would substantially reduce the impact of facility-based isolation. The effective capacity and the impact of facility-based isolation
varied by epidemic stage across regions. |
|
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Cheong, J, Yu, et al |
Nat Biomed Eng |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study shows that SARS-CoV-2 RNA can be detected in 17 min via a portable device integrating reverse transcription,
fast thermocycling (via plasmonic heating through magneto-plasmonic nanoparticles) and in situ fluorescence detection following magnetic clearance of the nanoparticles. The device correctly classified all nasopharyngeal, oropharyngeal and sputum samples from
75 patients with COVID-19 and 75 healthy controls, with good concordance in fluorescence intensity with standard RT-qPCR (Pearson coefficients > 0.7 for the N1, N2 and RPP30 genes). Fast, portable and automated nucleic acid detection should facilitate testing
at the point of care. |
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Chitiga-Mabugu, M, Henseler, et al |
South African Journal of Economics |
Economics | Économie |
This study applied a computable general equilibrium model linked to a microsimulation model to assess the potential
short-term effects on the South African economy of the ongoing COVID-19 pandemic. The findings show significant evidence of decline in economic growth and employment, with the decline harsher for the severe scenario. The microeconomic results show that the
pandemic moves the income distribution curve such that more households fall under the poverty line while at the same time, inequality declines. The latter result is driven by the disproportionate decline in incomes of richer households while the poorest of
the poor are cushioned by government social grants that are kept intact during the pandemic. |
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Colonnello, V, Leonardi, et al |
Psychol Med |
Mental Health |
|
This editorial reports that patients having more social contact, even if through remote means, experience less psychological
distress. Recruited all non-COVID-19 patients admitted to two hospitals in Emilia Romagna, an Italian region hard hit by COVID-19 outbreak. Results show that fear of COVID-19 and technology-mediated social interactions, along with anxiety and depression,
predict central but distinct aspects of psychological distress in hospitalized patients without COVID-19. |
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COVID-19 Down Under: Australia's Initial Pandemic Experience |
Cook, MJ, Dri, et al |
Int J Environ Res Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
This study provides a broad overview of the initial Australian epidemiological situation of the novel coronavirus disease
(COVID-19) pandemic. The results indicate the number of reported COVID-19 cases in Australia reduced, and Australia initially managed to successfully flatten the curve-from an initial doubling time of 3.4 days at the end of March 2020 to a doubling time of
112 days as of 20 April 2020. Using SEIR mathematical modelling, we investigate a scenario assuming infections increase once mitigation measures are lifted. In this case, Australia could experience over 15,000 confirmed cases by the end of April 2020. How
Australia's government, health authorities and citizens adjust to preventative measures to reduce the risk of transmission as well as the risk of overburdening Australia's health care system is crucial. Also presents the initial non-pharmaceutical intervention
measures undertaken by the Australian health authorities in efforts to mitigate the rate of infection, and their observed and predicted outcomes. |
|
Cox, RM, Wolf, et al |
Nat Microbiol |
Therapeutics| Thérapeutique Animal model | Modèle animal |
Here, we explored the efficacy of therapeutically administered MK-4482/EIDD-2801 to mitigate SARS-CoV-2 infection and
block transmission in the ferret model. We demonstrate high SARS-CoV-2 burden in nasal tissues and secretions, which coincided with efficient transmission through direct contact. Therapeutic treatment of infected animals with MK-4482/EIDD-2801 twice a day
significantly reduced the SARS-CoV-2 load in the upper respiratory tract and completely suppressed spread to untreated contact animals. This study identified oral MK-4482/EIDD-2801 as a promising antiviral countermeasure to break SARS-CoV-2 community transmission
chains. |
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Di Gialleonardo, Luca, Marè, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie |
This paper provides an empirical analysis of the relationship between the strength of family ties and the spread of
SARS-CoV-2. We observe a robust positive relationship between family ties and the contagion rate across the world; in particular, the attitude of parents towards the wellbeing for their children is the main force that drives the positive correlation with the
contagion. Instead, the respect toward parents (the variable love-parents) seems to be a component of the family ties which negatively correlates with the diffusion of SARS-CoV-2, leading to the final quadratic relationship between the overall family ties
strength and the spread of the virus. As conclusive evidence, we observe that the death rate, as well as the recovery rate, are not affected by the strength of family ties and other social capital variables. |
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Differentiating influenza from COVID-19 in patients presenting with suspected sepsis |
D'Onofrio, V, Van Steenkiste, et al |
Eur J Clin Microbiol Infect Dis |
Clinical data| Données cliniques |
The objectives of this study were to identify clinical, laboratory and imaging parameters that could differentiate
between influenza and COVID-19 and to assess the frequency and impact of early bacterial co-infection. Hypertension (OR 6.550), both unilateral (OR 4.764) and bilateral (OR 7.916), chest X-ray abnormalities, lower temperature (OR 0.535), lower absolute leukocyte
count (OR 0.857), lower AST levels (OR 0.946), higher LDH (OR 1.008), higher ALT (OR 1.044) and higher ferritin (OR 1.001) were predictive of COVID-19. Early bacterial co-infection was more frequent in patients with influenza (10.7% vs. 2.7%). |
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Dr-COVID: Graph Neural Networks for SARS-CoV-2 Drug Repurposing |
Doshi, Siddhant, Chepuri, et al |
arXiv |
Therapeutics| Thérapeutique |
In this work, we explore computational data-driven methods for drug repurposing and propose a dedicated graph neural
network (GNN) based drug repurposing model, called Dr-COVID. Although we analyze the predicted drugs in detail for COVID-19, the model is generic and can be used for any novel diseases. We provide a detailed analysis of the 150 potential drugs (such as Dexamethasone,
Ivermectin) predicted by Dr-COVID for COVID-19 from different pharmacological classes (e.g., corticosteroids, antivirals, antiparasitic). Out of these 150 drugs, 46 drugs are currently in clinical trials. |
|
Molecular basis of the logical evolution of the novel coronavirus
SARS-CoV-2: A comparative analysis |
Dwivedy, Abhisek, Murmu, et al |
bioRxiv |
Coronavirology| Coronavirologie |
The current report presents unique information regarding the amino acid residues that were a) conserved to maintain
the binding with ACE2 (Angiotensin-converting enzyme 2), and b) substituted to confer an enhanced binding affinity and conformational flexibility to the SARS-CoV-2 spike protein. The present study provides novel insights into the evolutionary nature and molecular
basis of higher infectability and perhaps the virulence of SARS-CoV-2. |
|
Temperament and character of patients with alcohol toxicity during COVID -19 pandemic |
Estedlal, AliReza, Mani, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
The main purpose of this study was to investigate the correlation between temperament and character and alcohol abuse.
Alcohol intoxicated patients had higher scores of novelty-seeking and self-transcendent and lower scores of reward-dependency scores, cooperativeness and self-directedness. These scores are associated with higher likelihood of personality disorders. |
|
Feasibility of a silicon thin film transistor-based aptamer sensor for COVID-19 detection |
Farrow, Thomas, Laumier, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
Here we report feasibility for the use of an intrinsic silicon thin film transistor functionalised with aptamers designed
to attach to the spike protein of COVID-19. It is shown that a linear response can be obtained in a concentration range of 1 pM to 1 nM. |
|
Finkenzeller, T, Faltlhauser, et al |
Med Klin Intensivmed Notfmed |
Epidemiology| Épidémiologie Immunology | Immunologie |
We examined seropravalence of SARS-CoV‑2 IgM/IgG antibodies (AB) in HCW of a region with the highest rate of infection
(1570/100,000) during COVID-19 pandemic in Germany, 4 months after its start. Seroprevalence of SARS-CoV‑2 antibodies in HCW of a region heavily affected by COVID-19 is with 15.1% significantly higher than in a control group of nonmedical staff with 3.7%.
Infection rate in HCW was higher in staff with close contact to infected patients. |
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Derivation and Validation of Clinical Prediction Rules for COVID-19 Mortality in Ontario, Canada |
Fisman, DN, Greer, et al |
Open Forum Infectious Diseases |
Epidemiology| Épidémiologie |
We used a public health case management data system to build and validate 4 accurate, well-calibrated, robust clinical
prediction rules for COVID-19 mortality in Ontario, Canada. Age and comorbidities (notably diabetes, renal disease, and immune compromise) were strong predictors of mortality. |
|
Freire, Danton, Llanovarced-Kawles, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In the present work, we adapted a recently published multi-group SEIRA model to represent the spreading dynamics of
COVID-19 in Chile, where different groups would represent geographically separated regions. Using national mobilization statistics to estimate the connectivity among such groups and the official COVID-19 reported data by the government, we fitted COVID-19
spreading and fatality rates, for every region. Then, we assessed the effectiveness of different governmental interventions on the spread of COVID-19. A comparison between the reproductive numbers (Rt) separately obtained from raw data and fitted parameters. |
|
|
Friedman, J, Beletsky, et al |
JAMA Psychiatry |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
We conducted a retrospective observational analysis using the National EMS Information System (NEMSIS), a large registry
of more than 10 000 EMS agencies in 47 states. Overdose-related cardiac arrests rose sharply during April 2020, reaching 74.1 per 100 000 EMS activations (123.4% above baseline) by May 4. Overdose-related cardiac arrests subsequently decreased but remained
elevated, reaching 48.7 per 100 000 EMS activations (53.7% above baseline) by July 27. |
|
|
Frolova, NF, Tomilina, et al |
Nephrology and Dialysis |
Clinical data| Données cliniques |
Article in Russian. Here we present four cases of AAV complicated by COVID-19, for which conventional therapy with
cyclophosphamide could not be applied due to the particularly high risk of serious infectious complications, and eculizumab was used off-label by decision of the medical council and special commission. |
|
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Fu, SQ, Greco, et al |
J Appl Psychol |
Mental Health |
|
Because stressor novelty, predictability, and patterns are central components of appraisal theories, we use the COVID-19
crisis as a context to illustrate how variation in the phenomenon's patterns of change but also the rate of linear velocity and nonlinear growth acceleration in cases influence anxiety. Our results show that although the impact of level of COVID-19 cases on
anxiety decreases over time, the effect of change in cases (velocity and acceleration) increases over time. Anxiety is then associated with next-day work functioning (engagement, performance, and emotional exhaustion). |
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A snapshot of COVID-19 infection in patients with solid tumors |
Fuentes-Antrás, J, Manzano, et al |
Int J Cancer |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Herein, we present a prospective analysis of epidemiological, clinical, radiological and laboratory data of consecutive
adult cancer patients seen in the Clínico San Carlos University Hospital (Madrid, Spain), and admitted to hospital and tested for COVID-19 between February 21 and May 8, 2020 due to clinical suspicion of infection. Most common findings on presentation included
cough (55%), fever (52%), and dyspnea (45%), and 32 (44%) patients showed oxygen saturation levels below 95%. Multivariable logistic regression adjusted for age and tumor stage showed higher odds of in-hospital death associated with a history of cardiovascular
disease, hospitalization in the previous 30 days, and several features on admission including dyspnea, higher qSOFA score, higher C-reactive protein levels, and an abnormal neutrophil count. |
|
Gaiha, SM, Lempert, et al |
JAMA Netw Open |
Public Health response| Interventions de santé publique |
This study aimed to examine whether underage youth and young adults who ever used e-cigarettes self-reported changes
in access and use of e-cigarettes since the COVID-19 pandemic began. During the COVID-19 pandemic, youth e-cigarette users reported changes in e-cigarette use, point-of-purchase, and ability to purchase e-cigarettes without age verification. |
|
|
Galvez-Romero, J, Palmeros-Rojas, et al |
J Intern Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
OBJECTIVE: To determine the added benefit of Cyclosporine-A (CsA), to low-dose steroid treatment, in patients with
COVID-19. RESULTS: Mortality was 22 and 35% for CsA and control groups, respectively, for all patients, and 24 and 48.5% for patients with moderate to severe disease. Higher cumulative clinical improvement was seen for the CsA group in moderate to severe
patients. |
|
|
Inference in mixed causal and noncausal models with generalized Student's t-distributions |
Giancaterini, Francesco, Hecq, et al |
arXiv |
Epidemiology| Épidémiologie |
This paper analyzes the properties of the Maximum Likelihood Estimator for mixed causal and noncausal models when the
error term follows a Student's t-distribution. In particular, we compare several existing methods to compute the expected Fisher information matrix and show that they cannot be applied in the heavy-tail framework. We illustrate how the different approaches
lead to different standard errors in four time series: annual debt to GDP for Canada, the variation of daily Covid-19 deaths in Belgium, the monthly wheat prices and the monthly inflation rate in Brazil. |
|
Gómez-Escobar, LuisG, Gómez-Escobar, et al |
Research Square prepub |
Clinical data| Données cliniques |
We aimed to assess the differences in inflammatory cytokines in COVID-19 patients compared to contemporaneously hospitalized
controls and then analyze the relationship between these cytokines and the development of Acute Respiratory Distress Syndrome (ARDS), Acute Kidney Injury (AKI) and mortality. Macrophage-associated cytokines predicted ARDS , T cell immunity related cytokines
predicted AKI and mortality was was associated with cytokines of activated immune pathways, of which IL-13 was universally correlated with ARDS, AKI and mortality. |
|
|
Goodacre, S, Thomas, et al |
Emerg Med J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to determine the accuracy of post-exertional oxygen saturation for predicting adverse outcome in suspected
COVID-19. Results: Multivariable analysis showed that post-exertion oxygen saturation was not a significant predictor of adverse outcome when baseline clinical assessment was taken into account. |
|
|
Goodhue Meyer, EK, Xu, et al |
Transfusion |
Epidemiology| Épidémiologie Immunology | Immunologie |
Between 27 March and 14 May, 67 810 potential CCP donors registered via the ARC Web site; 38 085 (56%) acknowledged
either an existing diagnostic COVID‐19 polymerase chain reaction (PCR) or serologic test. A total of 36.4% of donors without diagnostic testing had a reactive VITROS test, with an overall median S/CO of 0.11. Among the donors with diagnostic testing, the
early recovery group had 82.3% reactivity (overall median S/CO, 26.2). Those further in recovery had 91.9% (overall median S/CO, 129.5). Statistically, by χ2 analysis, the percentage of donors with reactivity was significantly different among the three groups.
Our seroreactivity evaluation in CCP donors presenting with and without a diagnostic COVID‐19 PCR test highlights the importance of testing to enrich for donors with SARS‐CoV‐2 antibodies. |
|
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Remote Patient Monitoring Program for Hospital Discharged COVID-19 Patients |
Gordon, WJ, Henderson, et al |
Applied clinical informatics |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
We deployed a Remote Patient Monitoring (RPM) program to monitor patients with coronavirus disease 2019 (COVID-19)
upon hospital discharge. RESULTS: A total of 295 patients were referred for RPM from five participating hospitals, and 225 patients were enrolled. Enrollment was associated with a decreased odds of ED or hospital readmission . |
|
Global Impact of the COVID-19 Pandemic on Paediatric Cancer Care |
Graetz, Dylan, Agulnik, et al |
SSRN- Lancet prepublication |
Healthcare Response | Réponse des soins de santé |
This study assessed the effect of the COVID-19 pandemic on childhood cancer care worldwide. Findings: Seven percent
of centres reported complete closure of paediatric haematology-oncology services. Overall, 43% of centres reported fewer than expected paediatric cancer diagnoses and 34% reported increased treatment abandonment. Institutions described reductions in clinical
staff (66%) and decreased financial support (32%). Changes to cancer care delivery included: reduced surgical care (79%), blood product shortages (60%), chemotherapy modifications (55%), and interruptions to radiotherapy (40%). |
|
Gurgel, RQ, de Sá, et al |
J Infect |
Epidemiology| Épidémiologie Immunology | Immunologie |
We report here evidence that SARS-CoV-2 may have circulated in the Northeast of Brazil before the first COVID-19 cases
were reported in the region. We obtained 987 anonymized serum samples collected from January 2020 to April 2020. 989 samples were tested for SAR-CoV-2 antibodies using two different methods; 16 (1.6%) were positive (7 (43.8%) IgM, 3 (18.8%) IgG and 6 (37.5%)
IgG/IgM positive), suggesting SARS-CoV-2 had circulated before the first reported COVID-19 case in Brazil. |
|
|
Guzmán-Torres, José Alberto, Alonso-Guzmán, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The present work describes the estimation of the principal diseases or conditions that produces death in patients with
COVID-19 through a numerical approach based on advanced techniques such as Machine Learning. The analysis reveals that the first ten causes of death are related to age, bad eating habits, and chronic diseases, as well as contact with patients carrying the
virus without proper care. The model indicates a 67 percent probability of death in case of having the conditions mentioned above with an accuracy of 93 percent. |
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Haire, E, Brown, et al |
J Pain Symptom Manage |
Healthcare Response | Réponse des soins de santé |
This study aims to capture the Companions’ experience and activities, including qualitative feedback, as well as outline
recommendations for this role in future services and training. RESULTS: The majority of Companions were from the physiotherapy team with a range of experience working in the NHS. In total 64 patients were seen over 382 visits. The Companions often carried
out more than one activity per visit including communication with the patient and NOK, personal care, literature and spirituality. |
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Hamadé, A, Woehl, et al |
Blood Coagul Fibrinolysis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this work was to evaluate the incidence of aPL antibodies in patients hospitalized in conventional
unit for coronavirus disease 2019 (COVID-19) infection and confirmed venous thromboembolic events (VTE) associated with aPL antibodies. aPL antibodies were significantly associated with the transfer to ICUs. Nine patients (22%) developed VTE and seven (17%)
were positive for aPL antibodies of which five had isolated positive lupus anticoagulant. |
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Life in lockdown: Experiences of patients with IBD during COVID-19 |
Harris, RJ, Downey, et al |
BMJ Open Gastroenterology |
Healthcare Response | Réponse des soins de santé |
. We aimed to assess the experience of patients with IBD during the COVID-19 lockdown. Results: 87% did not change
their IBD medication, with most reported changes initiated by the IBD team. 39% were worried about their IBD care, but most services were largely uninterrupted. 90% received 'at-risk' notification often from multiple sources, but 17% not until May. |
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Henry, BM, Benoit, et al |
Int J Lab Hematol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this investigation, we aimed to evaluate ADAMTS13 activity, von Willebrand factor level (VWF:Ag), and the corresponding
ADAMTS13 activity/VWF:Ag ratio, in patients with COVID‐19 and for associations with disease progression and acute kidney injury (AKI). Results: A low ADAMTS13 activity:VWF:Ag ratio at ED presentation is associated with progression to severe COVID‐19 disease
and severe AKI, with a pattern suggestive of a secondary microangiopathy. |
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Herikurniawan, Herikurniawan, Rumende, et al |
Research Square prepub |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study aimed to find the best diagnostic model by using a simple and widely available parameter, so that the final
scoring system could be utilised in resource-limited setting. The selected variables in this scoring system were contact history, fever/history of fever, dyspnea with respiratory rate >20 breaths/minute, leucocyte ≤ 10.000 cells/mL and typical chest radiography.
The area under the curve for this model was 0,777 (CI 95% (0,706-0,847), P<0,001). The probability was 82% with a cut-off point ≥ 4, PPV: 74%, NPV: 77%. |
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Ho, FK, Celis-Morales, et al |
BMJ Open |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to investigate demographic, lifestyle, socioeconomic and clinical risk factors for COVID-19, and compared
them to risk factors for pneumonia and influenza in UK Biobank. Among 235 928 participants, 397 had confirmed COVID-19. After multivariable adjustment, modifiable risk factors were higher body mass index and higher glycated haemoglobin (HbA1C), smoking, slow
walking pace as a proxy for physical fitness, and use of blood pressure medications as a proxy for hypertension. Higher forced expiratory volume in 1 s (FEV1) and high-density lipoprotein (HDL) cholesterol were both associated with lower risk. Non-modifiable
risk factors included male sex, black ethnicity, socioeconomic deprivation, and high cystatin C. |
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Hsiao, YH, Lin, et al |
J Chin Med Assoc |
Clinical data| Données cliniques |
Herein, we demonstrated serial LUS changes in a 75-year-old woman recovering from COVID-19 with acute respiratory distress
syndrome (ARDS) in need of veno-venous extracorporeal membrane oxygenation support. LUS initially revealed extensive consolidation in the bilateral lower lung (BLL) fields with coalescent B-lines. While the patient recovered from ARDS, the findings gradually
changed to discrete B-lines and small pleural consolidations. The LUS findings were more sensitive than those of the CXR in detecting re-expansion of the lungs by showing B-lines instead of consolidations in the BLL fields immediately after recruitment maneuver
(RM). Compared with physiological parameters, LUS findings provided more precise information about the parts of the lungs that had been recruited by RM. |
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Visiting in disguise: Analysis of inpatient companions in the time of COVID-19 |
Hung, SH, Kuo, et al |
J Chin Med Assoc |
Healthcare Response | Réponse des soins de santé |
This study aims to evaluate the impact of the new regulations to the accompanying and visiting culture in Taiwan, via
analyzing the appearance and characteristics of inpatient companions in this period. Using intelligent technology, we designed a novel system in managing the inpatient companions (InPatients Companions Management System IPCMS]), and the IPCMS was used to collect
data about characteristics of inpatients and companions between April 27 and May 3, 2020. Daily inpatient admissions ranged from 2242 to 2514, the number of companions per day ranged from 2048 to 2293, and the number of companions for one inpatient was 1 to
9 per day, with an average of 1.20 to 1.26. The companions were mostly family members, and most of them were the inpatients' children (32.9%), and spouse (26.13%). |
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Evolutionary and structural analysis of SARS-CoV-2 specific evasion of host immunity |
Hussain, I, Pervaiz, et al |
Genes Immun |
Coronavirology| Coronavirologie Immunology | Immunologie |
Here, we show that structural evolution of macrodomains may impart a critical role to the unique pathogenicity of SARS-CoV-2.
Using sequence, structural, and phylogenetic analysis, we identify a specific set of historical substitutions that recapitulate the evolution of the macrodomains that counteract host immune response. These evolutionary substitutions may alter and reposition
the secondary structural elements to create new intra-protein contacts and, thereby, may enhance the ability of SARS-CoV-2 to inhibit host immunity. Further, we find that the unusual virulence of this virus is potentially the consequence of Darwinian selection-driven
epistasis in protein evolution. |
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PMC7695094; Epidemiology of COVID-19 and Predictors of Outcome in Nigeria: A Single-Center Study |
Ibrahim, OR, Suleiman, et al |
Am J Trop Med Hyg |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This single-center study described the clinical features, laboratory findings, and predictors of in-hospital mortality
of COVID-19 patients. The independent predictors of mortality were hypoxemia (adjusted odds ratio [aOR]: 2.5; 95% CI: 1.3–5.1) and creatinine > 1.5 mg/dL (aOR: 4.3; 95% CI: 1.9–9.8). |
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Indini, A, Cattaneo, et al |
Cancer |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
The objective of this study was to evaluate the efficacy of triage to identify COVID-19 among patients with cancer.
Overall, 562 patients were enrolled. Six patients (1%) were diagnosed with COVID-19. Seventy-one patients had suspect symptoms and/or altered laboratory tests that were not included in the diagnostic algorithm and, of these, 47 patients underwent testing for
SARS-CoV-2 antibody: 6 were positive for IgG (n = 5) or for both IgM and IgG (n = 1), and antibody tests were negative in the remaining 41 patients. Telehealth triage was helpful in detecting suspect patients and to keep a COVID-19-free cancer center. The
overall incidence of COVID-19 diagnosis (1%) and antibody positivity (13%) in patients with suspect symptoms was similar to that observed in the general population. |
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Jacobs, J, Eichbaum, et al |
Transfusion |
Clinical data| Données cliniques |
CASE REPORT: A patient with no known risk factors or underlying predisposition for developing Autoimmune hemolytic
anemia (AIHA) presented to a hospital with vague symptoms and profound anemia with a complicated blood bank evaluation. She was found to have COVID-19 and AIHA, for which extensive laboratory testing was performed, including direct antiglobulin tests, elution
studies, and cold agglutinin titers, to identify the causative autoantibody. She required multiple blood transfusions and therapeutic interventions prior to clinical stabilization. Many diseases have been associated with a propensity for developing AIHA, however
there are few cases in the literature of patients with COVID-19 and AIHA. Most of the reports involve patients with other underlying conditions that are known to be associated with the development of AIHA. The presentation, clinical findings, and therapeutic
interventions in a patient with severe AIHA, without other underlying conditions, in the setting of COVID-19 are discussed. |
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Janiri, D, Kotzalidis, et al |
Frontiers in Psychiatry |
Mental Health |
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To study the long-term psychological effects of Covid-19 disease, we recruited 61 patients older than 60 years of age
and administered the Kessler questionnaire K10 to assess psychological distress and classify them according to mental health risk groups. Patients were divided in two samples according to their scores on the K10, i.e., a high likelihood of psychological distress
group (N = 18) and a low likelihood of psychological distress group (N = 43). The two groups differed on their gender composition, in that more women (N = 11) were in the former and more men in the latter (N = 29). |
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Perceived Stress and Daily Well-Being During the COVID-19 Outbreak: The Moderating Role of Age |
Jiang, D |
Frontiers in Psychology |
Mental Health |
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To better understand older adults’ wellbeing during the COVID-19 outbreak, we examined age differences in daily affective
experiences in this study. I found that older adults reported lower perceived stress related to COVID-19 in daily life, compared to younger adults. The negative relationship between daily perceived stress and high arousal positive affect and the positive relationship
between daily perceived stress and high arousal negative affect was weaker in older than younger adults. |
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Mental health status of Chinese residents during the COVID-19 epidemic |
Jiang, W, Liu, et al |
BMC Psychiatry |
Mental Health |
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This study aimed to investigate the mental health status of Chinese residents during the epidemic of COVID-19, as well
as to identify the positive and negative factors and regulatory effect of negative cognitive processing bias on mental health. Chinese residents exhibited a high prevalence of anxiety and depressive symptoms during the epidemic. |
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Jin, Xurui, Jin, et al |
Research Square prepub |
Epidemiology| Épidémiologie Transmission |
Our study aim at examining the assocaiton between having COVID-19 cases in the neighborhood and public facilities.
We used a case-control design (4,329 cases vs. 17,316 controls) to investigate the association between having COVID-19 cases in the neighborhood and the number and types of public facilities nearby. In the multivariable logistics regression model, having more
restaurants, shopping centers, hotels, living facilities, recreational facilities, public transit, educational institutions, and health service facilities was associated with significantly higher odds of having COVID-19 cases in a neighborhood. The associations
for restaurants, hotels, reactional and education facilities were more pronounced in cities with fewer than six million people than those in larger cities. |
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High risk factors associated with severity of COVID-19 patients |
Jing, X, Lin, et al |
Medical Journal of Chinese People's Liberation Army |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to explore the high risk factors associated with severity of COVID-19 to provide a basis for precise
diagnosis and treatment. 143 confirmed patients with COVID-19 were enrolled, the average age was 43.5 years, 81 cases were male, 28 cases had at least one comorbidity. The most common symptom was fever (119), followed by dry cough (77). 122 patients had continued
improvement (stable group), and 21 deteriorated within 2 weeks of symptoms onset (severe group). Multivariate COX proportional hazards regression analysis showed that age over 60 years (HR=3.5, 95% CI 1.4-9.0), combined with underlying diseases (HR=3.9, 95%
CI 1.5-10.4), LDH>250.0 U/L (HR=4.1, 95% CI 1.4-12.6), and absolute lymphocyte count less than 1.0×109/L (HR=6.8, 95% CI 2.3-20.7) were high risk factors for COVID-19 patient deterioration. |
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Trust in the Bangladeshi Health System During the COVID-19 Pandemic: A Mixed-Methods
Exploration |
Joarder, Taufique, Bin Khaled, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
Our aim was to determine levels of impersonal and interpersonal trust in the context of COVID-19 pandemic response
in Bangladesh. Survey respondents have less trust in the health system (a mean score of 3.77/10) than in the service providers (4.95/10). The lowest level of impersonal trust is observed in the Fairness domain (3.12/10), followed by the Confidence domain (3.38/10).
Several participants cited lack of fairness in pandemic management, such as imposing lockdown in periphery areas of the country without arranging transport for those requiring medical help to the centrally located modern health facilities, and visible attempts
by the political decision-makers to protect the business interests without consideration for the safety of the poor. Both clinicians and non-clinicians concurred on the need for the service providers to improve communication related to COVID-19 management. |
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Public Perceptions of the COVID-19 Pandemic Management in Bangladesh: A Qualitative
Exploration |
Joarder, Taufique, Bin Khaled, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
This qualitative study aims to explore the public perceptions of pandemic management efforts by the Bangladeshi health
sector decision-makers. The study participants concurred that, from the outset, decision-makers failed to engage the right kind of experts, which resulted in poor pandemic management that included imposing lockdown in periphery areas without arranging patient
transport to the center, declaring certain hospitals as COVID-19 dedicated without preparing the facilities or the staff, and engaging private hospitals in care without allowing them to test the patients for COVID-19 infection. Several participants also commented
on ineffective actions on behalf of the GoB, such as imposing home quarantine instead of an institutional one, weak point-of-entry screening, corruption, miscommunication, and inadequate private sector regulation. |
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Jones, CR, Hamilton, et al |
J Infect |
Epidemiology| Épidémiologie Immunology | Immunologie |
We present a nested cross-sectional study to obtain seroprevalence results amongst HCWs and support staff at North
Bristol NHS Trust that are robust to selection bias. The overall rate of SARS-CoV-2 seroprevalence among tested HCWs and support staff was 9.3% (638/6858). Seroprevalence was similar between females and males. Seroprevalence generally decreased with age, being
highest in those aged ≤20y and lowest in those aged ≥71y. Seroprevalence ranged from 12.0% in the most deprived IMD decile to 8.4% in the least deprived (p<0.01). Staff seroprevalence in the ICU was 2.5% and it was 16.2% in the acute medical unit. We found
13.6% (respiratory ward) and 20.9% (elderly care) seroprevalence on the two designated COVID-19 inpatient wards. We found high seroprevalence in staff working in wards that experienced outbreaks. |
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Just, J, Puth, et al |
BMC Fam Pract |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to identify anamnestic items with an increased/decreased odds ratio for a positive SARS-CoV-2 PCR (CovPCR)
result in a primary care setting. We performed a multi-center cross-sectional cohort study on predictive clinical characteristics for a positive CovPCR over a period of 4 weeks in primary care patients in Germany. 374 patients in 14 primary care centers received
CovPCR and were included in this analysis. The median age was 44.0. Forty tested positive for COVID-19. Patients who reported anosmia had a higher odds ratio for a positive test result while patients with a sore throat had a lower OR. Patients who had a first
grade contact with an infected persons and showed symptoms themselves had an increased OR for positive testing. This correlation was also present when they themselves were still asymptomatic. |
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Kaeuffer, C, Le Hyaric, et al |
Euro Surveill |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Our objective was to identify risk factors predictive of severe disease and death in France. In this prospective cohort
study, we included patients ≥ 18 years old with confirmed COVID-19, hospitalised in Strasbourg and Mulhouse hospitals (France), in March 2020. We respectively compared patients who developed severe disease (admission to an ICU or death) and patients who died,
to those who did not, by day 7 after hospitalisation. Among 1,045 patients, 41% had severe disease, including 32% who were admitted to ICU, and 11% who died. Mean age was 66 years, and 59% were men. Almost 75% of patients with BMI data had a BMI ≥ 25 kg/m2.
Overweightedness, obesity, advanced age, male sex, comorbidities, dyspnoea and inflammation are risk factors for severe COVID-19 or death in hospitalised patients. |
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Kalkan Uğurlu, Y, Mataracı Değirmenci, et al |
Perspect Psychiatr Care |
Mental Health |
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This study was conducted to examine the relationship between students' anxiety, depression, stress levels, and emotional,
external, restrictive eating behaviors in the coronavirus disease 2019 (COVID‐19) process. In the correlation between Depression, Anxiety, Stress Scale subscale scores, and the Dutch Eating Behavior Questionnaire subscale scores, there was no significant relationship
between only depression and restrictive eating. |
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Kant, A, Kostakoǧlu, et al |
Annals of Thoracic Medicine |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this study, we aimed to reveal the diagnostic value of chest computed tomography (CT) imaging with respect to symptom
duration. Chest CT findings were detected in 85.1% of the patients with a symptom duration of more than 2 days. In receiver operating characteristic analysis of this parameter, area under the curve (AUC) was 0.869, while sensitivity and specificity were 90.5%
and 76.2%, respectively. It was notable that chest CT findings were 7.17 times more common among the patients aged 60 years and older, with AUC, specificity, and positive predictive value of 0.768, 88.1%, and 84.8%, respectively. |
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The role of haematological parameters in patients with COVID-19 and influenza virus infection |
Kazancioglu, S, Bastug, et al |
Epidemiology and infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, the laboratory data of 120 COVID-19 patients, 100 influenza patients and 61 healthy controls were evaluated.
Lower lymphocytes, eosinophils, basophils, platelets and higher delta neutrophil index (DNI), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were found in COVID-19 and influenza groups compared to healthy controls. The eosinophils,
lymphocytes and PLR made the highest contribution to differentiate COVID-19 patients from healthy controls (area under the curves (AUCs): 0.819, 0.817 and 0.716, respectively; P-value is <0.0001 for all). The NLR, the optimal cut-off value was 3.58, which
resulted in a sensitivity of 30.8 and a specificity of 100 (AUC: 0.677, P < 0.0001). Higher leucocytes, neutrophils, DNI, NLR, PLR and lower lymphocytes, red blood cells, haemoglobin, haematocrit levels were found in severe patients at the end of treatment.
Nonsevere patients showed an upward trend for lymphocytes, eosinophils and platelets, and a downward trend for neutrophils, DNI, NLR and PLR. However, there was an increasing trend for eosinophils, platelets and PLR in severe patients. |
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Ketfi, A, Chabati, et al |
Pan African Medical Journal |
Clinical data| Données cliniques |
The objective of this study was to determine the clinical, biological and tomodensitometric profile of Algerian patients
hospitalized for COVID-19. The clinical profile of the 86 patients with COVID-19 was a male non-smoker, 53 years old, who was in 42% of the cases in contact with a suspected / confirmed case of COVID-19 and having a comorbidity in 70% of the cases cases (arterial
hypertension, diabetes mellitus, chronic respiratory pathology and allergy, heart disease). Clinical complaints were dominated by the “asthenia-fever-cough” triad in over 70% of cases. The most frequent laboratory abnormalities were: biological inflammatory
syndrome (90.1%), basocythemia (70.8%), lymphopenia (53.3%), increased lactic dehydrogenase (52.2%), anemia (38 , 7%), increased phosphokinase (28.8%) and hepatic cytolysis (27.6%). The most frequent CT signs were: frosted glass (91.8%), alveolar condensations
(61.2%), etched glass (60.0%), and nodular frosted glass (55.3%). Treatment with "chloroquine, azithromycin, zinc, vitamin C, enoxaparin, double antibiotic therapy and ± corticosteroids" was prescribed in 34.9% of patients. |
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Khalaf, Marwa, Bazeed, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to assess persistent symptoms in COVID-19 patients after clearance of SARS-CoV-2 infection. Mild symptoms
were reported in 61.3% of patients, 51.3% were admitted to hospital and 6.5% were admitted to ICU.Our study identified 49 types of persisting symptom. Fatigue (59.1%),sense of fever (46.5%), anorexia (24.3%) and diarrhea (24.3%) were the most commonly reported
persisting symptoms followed by loss of taste and smell (22.3%), headache (21.4%), cough (20.8), and dyspnea (21%). The use of hydroxychloroquine, azithromycin and multivitamins were significantly associated with persistence of symptoms (OR= 8.03, 8.89 and
10.12 respectively). |
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Tocilizumab-induced cytomegalovirus colitis in a patient with COVID-19 |
Khatib, MY, Shaik, et al |
Clinical Case Reports |
Clinical data| Données cliniques |
This is a case report of a 42 year old patient with COVID-19 and Tocilizumab-induced cytomegalovirus colitis. The authors
urge clinicians to observe for early signs of Cytomegalovirus (CMV) reactivation in patients presenting with gastrointestinal bleeding and intestinal perforation after receiving tocilizumab or other immunosuppressive therapy as a treatment for COVID 19. Early
recognition of CMV infection and treatment will prevent life‐threatening bleeding and mortality. |
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Optimizing SARS-CoV-2 Molecular Diagnostic Using N Gene Target |
Klein, Raphael Contelli, Fabres-Klein, et al |
SSRN- Lancet prepublication |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
we compared the fitness of two primers sets to the SARS-CoV-2 N gene in the molecular diagnosis of COVID-19. The 1029
patient samples were tested to presense/abscence molecular test using in house US CDC protocol. Both targets, N1 and N2 displayed similar fitness during testing with no differences between Ct or measurable viral genome copies. In addition, we verified security
ranges Cts related to positive diagnostic with Ct above 35 value failuring in 66,6% after retesting of samples. data suggest that it is secure to use just one primer set to the N gene to identify SARS-CoV-2 in samples and the labs should be careful to set
positive samples in high Ct values using high cutoffs. |
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Konishi, T |
PLoS One |
Coronavirology| Coronavirologie |
Coronaviruses and influenza viruses have similarities and differences. In order to comprehensively compare them, their
genome sequencing data were examined by principal component analysis. Coronaviruses had fewer variations than a subclass of influenza viruses. In addition, differences among coronaviruses that infect a variety of hosts were also small. These characteristics
may have facilitated the infection of different hosts. Although many of the coronaviruses were conservative, those repeatedly found among humans showed annual changes. If SARS-CoV-2 changes its genome like the Influenza H type, it will repeatedly spread every
few years. In addition, the coronavirus family has many other candidates for new pandemics. |
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Korn, SM, Lambertz, et al |
Biomol NMR Assign |
Coronavirology| Coronavirologie |
The coronavirus nucleocapsid protein (N protein) is an RNA-binding protein involved in viral transcription and replication.
Its primary function is the packaging of the viral RNA genome. The highly conserved architecture of the coronavirus N protein consists of an N-terminal RNA-binding domain (NTD), followed by an intrinsically disordered Serine/Arginine (SR)-rich linker and a
C-terminal dimerization domain (CTD). Besides its involvement in oligomerization, the CTD of the N protein (N-CTD) is also able to bind to nucleic acids by itself, independent of the NTD. Here, we report the near-complete NMR backbone chemical shift assignments
of the SARS-CoV-2 N-CTD to provide the basis for downstream applications, in particular site-resolved drug binding studies. |
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Krishna, MT, Beck, et al |
J Allergy Clin Immunol Pract |
Healthcare Response | Réponse des soins de santé |
This study investigates the impact of the pandemic on Allergy & Immunology (A&I) services in the UK. . There was a
reduction in nursing, medical, administrative and allied health professional staff during pandemic; 86% and 92% of A&I services continued to accept non-urgent and urgent referrals respectively during the pandemic. There were changes in immunoglobulin (Ig)
dose and infusion regimen in 67% and 14% of adult and pediatric services respectively; 30% discontinued immunoglobulin replacement in some patients. There was a significant (all variables, p≤0.0001) reduction in the following: face-to-face consultations (increase
in telephone consultations), initiation of venom immunotherapy, sublingual and subcutaneous injection immunotherapy, anesthetic allergy testing and hospital procedures (food challenges, immunoglobulin and omalizumab, administration); and a significant increase
(p≤0.0001) in home therapy for immunoglobulin and omalizumab. Adverse clinical outcomes were reported, but none were serious. |
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Measuring COVID-19 Related Anxiety in Parents: Psychometric Comparison of Four Different Inventories |
Kubb, C, Foran, et al |
JMIR Ment Health |
Mental Health |
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The purpose of this study is to compare the distributions, validities, and reliabilities of four different COVID-19
anxiety scales: Fear of COVID-19 Scale, Coronavirus Anxiety Scale, Pandemic Anxiety Scale, and one subscale of the COVID Stress Scales. Factor analysis suggests that existing COVID-19–related anxiety scales measure different latent constructs of anxiety. Furthermore,
all scales showed only small to moderate correlations with trait health anxiety, suggesting that COVID-19–related anxiety is distinct from general health anxiety. The adapted “disease anxiety” subscale of the Pandemic Anxiety Scale is an economical measure
for assessing COVID-19–related anxiety in parents. Directions for future research are outlined. |
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Kwon, JS, Kim, et al |
Am J Trop Med Hyg |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we comprehensively analyzed viral load, antibody responses to SARS-CoV-2, and cytokines/chemokines during
the disease course, and identified the factors related to severity. The viral load in patients with COVID-19 peaked at the early stage of the disease and continuously decreased. Severe and critical cases showed higher viral load and prolonged viral shedding
than asymptomatic and mild cases. Whereas plasma IgG was gradually increased and maintained during hospitalization, plasma IgM peaked at 3 weeks after symptom onset and dissipated. The antibody response in severe and critical cases was slightly delayed but
stronger than those in others. High levels of interferon (IFN)-α, IFN-γ–induced protein-10, monokine induced by IFN-γ, and interleukin-6 at 5–10 days from symptom onset were associated with the severity of COVID-19. |
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Lampe, C, Dionisi-Vici, et al |
Orphanet J Rare Dis |
Healthcare Response | Réponse des soins de santé |
The ongoing pandemic has caused disruption in the management and treatment of rare inherited metabolic disorders (IMDs).
Patients experienced extensive disruption of care, with the majority of appointments and treatments cancelled, reduced, or postponed. Almost all HCPs (90%) were able to substitute face-to-face visits with telemedicine, about half of patients facing treatment
changes switched from hospital to home therapy, and a quarter reported difficulties in getting their medicines. |
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Lani-Louzada, R, Ramos, et al |
PLoS One |
Clinical data| Données cliniques |
This was a case series observed during May 2020 in two referral centers for COVID-19 treatment in Rio de Janeiro, Brazil,
to evaluate the retinas of 47 severely or critically ill COVID-19 patients during their hospital stay. Retinal changes were present in 12% (3/25) of patients. The other 22 patients evaluated did not demonstrate convincing retinal changes upon examination.
There was no correlation between disease severity and admission serum levels of CRP, D-dimer and ferritin. These retinal changes, only seen after morbid developments, were likely secondary to clinical intercurrences or comorbidities instead of a direct damage
by SARS-CoV-2, and may be important and easily accessible outcome measures of therapeutic interventions and sentinels of neurologic and systemic diseases during COVID-19 pandemic. |
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Remdesivir Use in Patients Requiring Mechanical Ventilation due to COVID-19 |
Lapadula, G, Bernasconi, et al |
Open Forum Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
In our cohort of mechanically ventilated patients, Remdesivie (RDV) was not associated with a significant reduction
of mortality, but it was consistently associated with shorter duration of mechanical ventilation and higher probability of hospital discharge, independent of other risk factors. |
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Paediatric ED utilisation in the early phase of the COVID-19 pandemic |
Lee, L, Mannix, et al |
Emerg Med J |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to examine differences in the international experience of pediatric ED utilization
and disposition at five different children’s hospitals. Pediatric EDs in the five cities demonstrated differential decreases of ED volume by acuity and disposition during the early months of the COVID-19 pandemic. |
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Levine, DM, Lipsitz, et al |
J Gen Intern Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective: Derive and validate a risk score to predict suitability for discharge from a monitored setting among an
early cohort of patients with COVID-19. A 3-item risk score for patients with COVID-19 consisting of age, oxygen saturation, and an acute phase reactant (albumin) using point of care data predicts suitability for discharge and may optimize scarce resources. |
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Negative Age Stereotypes Associated with Older Persons' Rejection of COVID-19 Hospitalization |
Levy, BR, Provolo, et al |
J Am Geriatr Soc |
Public Health response| Interventions de santé publique |
The current study considered whether a psychosocial factor among older persons explains tthe resistance to hospitalization:
stress-inducing negative age stereotypes (disparaging characterizations of older persons as a category) that are assimilated from society. Negative age stereotypes significantly predicted a rejection of hospitalization for older persons who are extremely sick
with COVID-19, among older participants =.20, p=.04, but not among younger participants, =.14, p=.24. Also as hypothesized, negative age stereotypes did not predict views of whether younger persons who are extremely sick with COVID-19 should be hospitalized,
among older and younger participants, =.17, p=.09 and, =.19, p=.09, respectively. |
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Comparative analysis of SARS-CoV-2 and its receptor ACE2 with evolutionarily related coronaviruses |
Li, FF, Zhang, et al |
Aging |
Coronavirology| Coronavirologie zoonoses |
In this study, we conducted comparative analysis among SARS-CoV-2 and non-SARS-CoV-2 coronavirus strains to elucidate
their phylogenetic relationships. We found: 1, the SARS-CoV-2 strains analyzed could be divided into 3 clades with regional aggregation; 2, the non-SARS-CoV-2 common coronaviruses that infect humans or other organisms to cause respiratory syndrome and epizootic
catarrhal gastroenteritis could also be divided into 3 clades; 3, the hosts of the common coronaviruses closest to SARS-CoV-2 were Apodemus chevrieri (a rodent), Delphinapterus leucas (beluga whale), Hypsugo savii (bat) , Camelus bactrianus (camel) and Mustela
vison (mink); and 4, the gene sequences of the receptor ACE2 from different hosts could also be divided into 3 clades. The ACE2 gene sequences closest to that of humans in evolution include those from Nannospalax galili (Upper Galilee mountains blind mole
rat), Phyllostomus discolor (pale spear-nosed bat), Mus musculus (house mouse), Delphinapterus leucas (beluga whale), and Catharus ustulatus (Swainson's thrush). |
|
Tobacco smoking confers risk for severe COVID-19 unexplainable by pulmonary imaging |
Li, J, Long, et al |
J Intern Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Current study was designed to focus on smoking history in patients with COVID‐19 and test that tobacco smoking history
increases risk for severe COVID‐19. In our well‐characterized cohort of 954 patients including 56 with tobacco smoking history, smoking history increased the risk for severe COVID‐19 with an odds ratio (OR) of 5.5 (95% CI: 3.1–9.9; P = 7.3 × 10−8). Meta‐analysis
of ten cohorts of 2891 patients resulted in an OR of 2.5 (95% CI: 1.9–3.3; P < 0.00001). |
|
Lieveld, AWE, Azijli, et al |
Chest |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We aimed to prospectively validate the COVID-19 Reporting and Data System (CO-RADS) as a COVID-19 diagnostic tool
at the emergency department (ED), and evaluate if the corresponding CT severity score (CTSS) is associated with prognosis.741 patients were included. We found an AUC of 0.91 (CI 0.89-0.94) for CO-RADS using PCR as reference. The optimal CO-RADS cut-off was
4, with a sensitivity of 89.4% (CI 84.7-93.0) and specificity of 87.2% (CI 83.9-89.9). We found a significant association between CTSS and hospital admission, ICU admission, and 30-day mortality; adjusted odds ratios per point increase in CTSS were 1.19 (CI
1.09-1.28), 1.23 (1.15-1.32), 1.14 (1.07-1.22), respectively. Intra-class correlation coefficients for CO-RADS and CTSS were 0.94 (0.91-0.96) and 0.82 (CI 0.70-0.90). |
|
|
Liu, JY, Chen, et al |
J Chin Med Assoc |
Epidemiology| Épidémiologie |
The demographic characteristics and transmission dynamics of the community-acquired coronavirus disease 2019 (COVID-19)
cases in Taiwan were analyzed for more effective control and prevention of the community transmission of this novel disease. Of the 55 cases, 52.7% were female and 74.5% were between 20–59 years of age. One-sixth (16.4%) of community-acquired cases were asymptomatic.
More than half (58.2%) of the cases were identified via contact tracing. The median incubation period was 6 days (range 1-13 d) and the median serial interval was 4 days (range −3-24 d). Twenty-six cases (47.3%) were transmitted from presymptomatic cases,
11 cases (20%) from symptomatic cases, and 2 cases (3.6%) from an asymptomatic case. The contagious period of symptomatic cases was from 7 days before to 15 days after the onset of symptoms. |
|
|
Sec-Eliminating the SARS-CoV-2 by AlGaN Based High Power Deep Ultraviolet Light Source |
Liu, S, Luo, et al |
Advanced Functional Materials |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
In this work, by fully benefitting from high-quality AlN template (with threading dislocation density as low as ≈6×108
cm−2) as well as outstanding deep ultraviolet (UVC-less than 280 nm) light-emitting diodes (LEDs) structure design and epitaxy optimization, high power UVC LEDs and ultra-high-power sterilization irradiation source are achieved. Moreover, for the first time,
a result in which a fast and complete elimination of SARS-CoV-2 (the virus causes COVID-19) within only 1 s is achieved by the nearly whole industry-chain-covered product. |
|
Lv, Z, Lv, et al |
International Journal of Biological Sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A retrospective cohort study was conducted to summarize the clinical characteristics of patients with COVID-19 and
to explore the risk factors affecting the disease duration in Jiangan Fangcang shelter hospital, Wuhan, China. Clinical characteristics of 409 patients with COVID-19 were retrospectively analyzed. The median disease duration of all patients was 23 days (IQR
19-28). The main symptoms of the patient were fever (95.6%), cough (74.3%), and tiredness (21.5%). Comorbidities mainly included hypertension (30.6%) diabetes (17.6%) and heart disease (12.5%). The univariate Cox regression analysis showed that old age, number
of symptoms, the combination of hypertension, heart disease and pulmonary disease were associated with the progression of disease. The multivariate Cox regression analysis showed that old age (HR: 7.294; 95% CI: 1.442-36.888; P = 0.016), the combination of
hypertension (HR: 2.230; 95% CI: 1.090-4.562; P = 0.028) and heart disease (HR: 2.650; 95% CI: 1.079-6.510; P = 0.034) were independent risk factors for progression of COVID-19. |
|
|
Lyu, Hanjia, Wu, et al |
arXiv |
Public Health response| Interventions de santé publique |
Using more than 40,000 rigorously selected tweets (from over six million tweets collected using keywords) posted by
over 20,000 distinct Twitter users, we adopt a human-guided machine learning framework to capture the public opinions on the potential vaccines for SARS-CoV-2 and classify them into three groups: pro-vaccine, vaccine-hesitant, and anti-vaccine. A lower acceptance
level for the potential COVID-19 vaccines is observed among the socioeconomically disadvantaged groups. We further aggregate the opinions at the state and country levels, and find that the percentage of the pro-vaccine group is lower in the Southeast part
of the United States. Next, by conducting counterfactual analyses, we find that the U.S. public is most concerned about the safety, effectiveness, and political issues with regards to the potential vaccines for COVID-19. In particular, we also investigate
the public opinions about the newly emerged mRNA vaccines and find the opinions vary significantly across the religious beliefs: There are proportionally more religious people in the anti-vaccine group. |
|
|
Ma, L, Liu, et al |
Am J Trop Med Hyg |
Public Health response| Interventions de santé publique |
A self-designed questionnaire to assess residents’ knowledge, attitudes, and behaviors related to COVID-19 prevention
and control used the Questionnaire Star service platform, and snowball sampling was used to invite rural residents to complete the questionnaire on WeChat. A total of 554 valid questionnaires were collected. Rural residents’ average scores on knowledge, attitudes,
and behaviors regarding prevention and control were 40 ± 7 (total of 50 points), 45 ± 3 (total of 52 points), and 92 ± 12 (total of 127 points), respectively. A lack of protective materials and weak awareness of prevention and control are the greatest difficulties
and challenges experienced by rural residents during the epidemic. |
|
|
COVID-19 in a case previously infected with MERS-CoV: no
cross immunity |
Maani, AA, Al-Jardani, et al |
J Infect |
Clinical data| Données cliniques |
In this report, we discuss a confirmed case of COVID-19 in June 2020 in a physician who was diagnosed previously with
MERS-CoV infection in February 2019. This case of a mild human disease with the two zoonotic β-coronaviruses in the same host indicates that earlier infection did perhaps provide some but not complete cross-protection against SARS-CoV-2. |
|
Mahajan, NN, Mathe, et al |
J Assoc Physicians India |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study is to analyze the medical records of HCWs with COVID-19 retrospectively and carry out the analysis
of the data of HCWs with COVID-19. Interim analysis was carried out for the data collected from 6th April to 20th August 2020. Total 3711 HCWs (frontline, 74.32%, non-frontline, 25.68%) are working at NH Mumbai. We observed 11% prevalence of SARS-CoV-2 infection
among HCWs, 4% co-infection and 1% mortality. Majority (85%) of the HCWs with COVID-19 were symptomatic and 15% were asymptomatic. Comorbidities were reported in 19% of HCWs with COVID-19. Hypertension and Diabetes Mellitus were the most common co-morbidities
reported. More than 4% percent of HCWs with COVID-19 were also positive for plasmodium vivax Malaria. |
|
|
Prediction of COVID-19 active cases using exponential and non-linear growth models |
Mahanty, C, Kumar, et al |
Expert Systems |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This article adopted two non-linear growth models (Gompertz, Verhulst) and exponential model (SIR) to analyse the coronavirus
pandemic across the world. All the models have been used for active COVID-19 patients predictions based on the data collected from John Hopkins University repository in the time period of January 30, 2020 to June 4, 2020. Outbreak of COVID-19 disease has been
analysed for India, Pakistan, Myanmar (Burma), Brazil, Italy and Germany till June 4, 2020 and predictions have been made for the number of positive cases for the next 28 days. Verhulst model fitting effect is better than Gompertz and SIR model with R-score
0.9973. The proposed model perform better as compare to other three existing models with R-score 0.9981.These above models can be adapted to forecast in long term intervals, based on the predictions for a short interval as of June 5, 2020 and June 30, 2020,
active COVID-19 patients for India, Pakistan, Italy, Germany, Brazil and Myanmar predicted as (236,170, 88,998, 234,066, 184,922, 645,057 and 235) and (486,357, 218,864, 240,545, 193,727, 1,211,567 and 309). |
|
Maharlouei, N, Asadi, et al |
Am J Trop Med Hyg |
Public Health response| Interventions de santé publique |
This cross-sectional study was conducted on a statistical sample of pregnant women in southwestern Iran between March
and April 2020 to evaluate their knowledge and attitude n the prevention of COVID-19. The mean score of knowledge among 540 respondents was 34 (±4.1) out of 43. Also, 44.3% answered more than 80% of the items correctly. Higher knowledge scores were accordingly
associated with marriage duration, area of residence, health insurance coverage, socioeconomic status (SES), and self-rated health status. However, a strong relationship was found between knowledge, SES, and health insurance coverage with reference to multivariate
analysis results. Moreover, majority of the pregnant women and their households expressed their concern about using preventive measures against COVID-19. Although most respondents were moderately worried about becoming infected with COVID-19, 264 (48.9%) cases
reported that they were very much anxious about their newborns being infected with COVID-19 and 388 (71.9%) individuals asserted that they were worried about their mortality due to this infection. Besides, most mothers maintained that they had some degrees
of rumination, which could interfere with their routine daily chores. |
|
|
Mahmud, Tanvir, Rahman, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper, an automated COVID-19 lesion segmentation scheme is proposed utilizing a highly efficient neural network
architecture, namely CovSegNet. |
|
|
Impact of SARS-CoV-2 pandemic on bariatric care in Poland: results
of national survey |
Major, P, Stefura, et al |
BMC Surg |
Healthcare Response | Réponse des soins de santé |
The study was planned to identify the impact of the SARS-CoV-2 pandemic on bariatric care in Poland. The online survey
was designed and distributed to bariatric surgeons. 49 surgeons participated in the survey. 27 (55%) participants worked in hospitals transformed into COVID-dedicated units. Only 9 (18%) respondents declared uninterrupted bariatric surgery during a pandemic.
91% of surgeons declared continuation of bariatric care with telemedicine techniques. All participants declared a high willingness to resume bariatric surgery after the SARS-CoV-2 pandemic and responded that bariatric procedures should resume immediately when
World Health Organisation (WHO) announces the end of a pandemic regardless of oncological treatment. 90% of respondents believe that the pandemic will not affect the safety of bariatric procedures in the future. |
|
Makarenkov, Vladimir, Mazoure, et al |
bioRxiv |
Coronavirology| Coronavirologie zoonoses |
In this study we investigate the evolutionary patterns of 11 main genes of SARS-CoV-2. The results of our horizontal
gene transfer and recombination analysis suggest that SARS-Cov-2 could not only be a chimera resulting from recombination of the bat RaTG13 and Guangdong pangolin coronaviruses but also a close relative of the bat CoV ZC45 and ZXC21 strains. They also indicate
that a GD pangolin may be an intermediate host of SARS-CoV-2. |
|
|
Manny, Emilie, Carroll, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
Children from Edmonton, Canada participated in a longitudinal SARS-CoV-2 seropositivity study (n=565). The study found
SARS-CoV-2 seropositivity in a the sample to be low. None reported a positive SARS-CoV-2 RT-PCR result prior to recruitment, nine children (1·6%) were likely seropositive. Children who did not wear a mask (never, rarely, occasionally) had a 4·2% (5/118) prevalence
of being likely seropositive versus 0·9% (4/423) likely seropositive for children who often or always wore their mask (p<0·05). |
|
|
Marchini, S, Zaurino, et al |
Journal of community psychology |
Mental Health |
|
Evaluated the risks and protective factors in mental health in 825 emerging adults aged from 18 to 25 years old in
Belgium and in Italy. The group who experienced an increase in mental healthcare needs represented almost 5% of the assessed youth. Statistically significant differences were found in means of resilience scale for adults total score and RSA perception of
self. |
|
|
Mascitti, H, Bonsang, et al |
Open Forum Infectious Diseases |
Clinical data| Données cliniques |
A cross-sectional study on among all patients hospitalized in acute care for COVID-19 and included all patients with
cutaneous features (n=59). Several cutaneous manifestations were found: macular exanthema (80%), face edema (32%), livedo (13%), urticarial rash (8%), purpura (5%), oral lichenoid lesions (33%), and conjunctivitis (18%). Cutaneous biopsy was performed in 17
patients. Histological findings showed mast cell hyperplasia (100%), superficial perivascular infiltrate of lymphocytes (94%), and superficial edema (47%) consistent with capillary leak. |
|
|
Mateso, Guy-Quesney, Mateso, et al |
Research Square prepub |
Clinical data| Données cliniques |
Report on two cases (one 55-year-old man and one 25-year-old woman) of acute respiratory distress secondary to atypical
pneumonia seen in Bukavu, in Eastern Democratic Republic of the Congo (DRC). |
|
|
McMullen, E, Robson, et al |
Hand Therapy |
Healthcare Response | Réponse des soins de santé |
Explore the experience of hand units across the UK in determining the safe and judicious use of audio-visual outpatient
care for the management of acute upper limb trauma. |
|
|
Self-reported cutaneous manifestations in 1429 Brazilian COVID-19-infected patients |
Miot, HA, Ianhez, et al |
Journal of the European Academy of Dermatology and Venereology |
Clinical data| Données cliniques |
Evaluate the prevalence of dermatologic manifestations reported by patients with COVID‐19 using an electronic survey,
in Brazil. Thirty‐one per cent (95% CI: 28%–33%) of participants with COVID‐19 presented at least one dermatologic manifestation. Palmar erythema (OR = 3.6) and scalp erythema (OR = 2.1) were associated with hospitalization. |
|
Miryan, M, Soleimani, et al |
Trials |
RCT |
Double-Blind, Placebo-Controlled, Parallel Arm, Randomized Phase ΙΙ Clinical Trial - Protocol |
|
|
Moat, SJ, Zelek, et al |
Ann Clin Biochem |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
A new screening laboratory infrastructure was developed using an Enzyme-Linked Immunosorbent assay (ELISA) to detect
IgG antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein in DBS specimens. Paired plasma and DBS specimens from SARS-CoV-2 antibody positive and negative subjects and PCR positive subjects were tested. The study confirms SARS-CoV-2
IgG RBD antibodies can be reliably detected in DBS. |
|
|
Monreal, E, Maza S, et al |
Journal of medical virology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In the cohort of COVID‐19 patients, nonsevere immunosuppression (IS) was associated with a lower risk of moderate–severe
acute respiratory distress syndrome. A significantly lower proportion of IS patients (25.9%) compared to non‐IS patients (52.3%) developed moderate–severe ARDS, in both unadjusted (0.32; 95% CI, 0.13–0.83; p = .017) and adjusted (aOR, 0.25; 95% CI, 0.08–0.80;
p = .019) analyses. |
|
|
Colorimetric Detection of SARS-CoV-2 and Drug-Resistant pH1N1 Using CRISPR/dCas9 |
Moon, J, Kwon, et al |
ACS Sens |
Coronavirology| Coronavirologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Report a colorimetric viral detection method based on the clustered regularly interspaced short palindromic repeats
(CRISPR)/Cas9 endonuclease dead (dCas9) system. In this method, RNA in the viral lysate was directly recognized by the CRISPR/dCas9 system with biotin-protospacer adjacent motif (PAM)-presenting oligonucleotide (PAMmer). Streptavidin-horseradish peroxidase
then bound to biotin-PAMmer, inducing a color change through the oxidation of 3,3′,5,5′-tetramethylbenzidine. |
|
Moreira, LVL, de Souza Luna, et al |
J Infect |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Evaluated the detection of viral genomic RNA (gRNA) in 74 hospitalized patients admitted to hospital with negative
results in naso- or oropharyngeal swabs, including 3 patients with SARS-CoV-2-positive nasopharyngeal and stool samples as a control group. The investigators were able to detect the SARS-CoV-2 sgRNA of the E and N genes in positive stool samples. |
|
|
Local governments' communication through Facebook. Evidences from COVID-19 pandemic in Italy |
Mori, E, Barabaschi, et al |
Journal of Public Affairs |
Public Health response| Interventions de santé publique |
The study aims at demonstrating how social communication has changed in terms of flows and content in the different
phases of the COVID-19 pandemic to get to the fact that public administrations have embarked on a path of rapprochement with the citizen that starts from the methods of communication and interaction. This article presents an exploratory and multidisciplinary
study conducted through the analysis of the Facebook page of the Italian municipalities with the highest Covid19-induced mortality rates. |
|
Mporas, I, Naronglerdrit, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Present an evaluation of several well-known pretrained deep convolutional neural networks models in a transfer learning
setup for COVID-19 detection from chest X-ray images. |
|
|
ArCorona: Analyzing Arabic Tweets in the Early Days of Coronavirus(COVID-19) Pandemic |
Mubarak, Hamdy, Hassan, et al |
arXiv |
Public Health response| Interventions de santé publique |
We present the largest manually annotated dataset of Arabic tweets related to COVID-19. We describe annotation guidelines,
analyze our dataset and build effective machine learning and transformer based models for classification. We took a random sample of 1000 tweets and annotated them for their topics. In addition to health, the virus affected many aspects of people’s lives such
as politics, economy, education, etc. We found also that 7% of tweets have hate speech, e.g. attacking China and Iran for spreading the virus. |
|
High incidence of stroke and mortality in pediatric critical care patients with COVID-19
in Peru |
Munoz, Alvaro Coronado, Munoz, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A study analyzing the factors associated with mortality in pediatric critical care patients with COVID-19. The mortality
of the study sample was 21.3%; mortality risk among patients with neurological presentation was 45.5%. Other risk factors for mortality in the cohort were strokes and comorbidities. |
|
Najafi, A, Ghanei, et al |
Tanaffos |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The present study was done to retrospectively assess the treatment strategies (e.g., pharmaceutical care services)
for COVID-19 patients in selected hospitals and highlight the importance of such services in the management of a pandemic. Diverse medication classes and old drugs with or without strong evidence of therapeutic effects against the novel coronavirus, some previously
tried as a treatment for SARS-CoV and MERS-CoV, were mostly used for the treatment of patients in the hospitals. Many medications (broad-spectrum antibiotics and antivirals) or combination therapies are used without evidence of their therapeutic effects during
pandemics. |
|
|
Nunes, BP, Souza, et al |
Cadernos de saude publica |
Epidemiology| Épidémiologie |
This study aimed to measure the occurrence of multimorbidity and to estimate the number of individuals in the Brazilian
population 50 years or older at risk for severe COVID-19. This was a cross-sectional nationwide study based on data from the Brazilian Longitudinal Study of Aging (ELSI-Brazil), conducted in 2015-2016, with 9,412 individuals 50 years or older. An estimated
2.4 million Brazilians are at serious health risk. The results revealed inequalities according to schooling. The number of persons 50 years or older who presented risk conditions for severe COVID-19 is high both in absolute and relative terms. The estimate
is important for planning strategies to monitor persons with chronic conditions and for preventive strategies to deal with the novel coronavirus. |
|
|
Odagaki, T |
Physica A |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
The SIQR model is reformulated where compartments for infected and quarantined are redefined so as to be appropriate
to COVID-19, and exact properties of the model are presented. It is shown that the maximum number of infected at large depends strongly on the quarantine rate and that the quarantine measure is more effective than the lockdown measure in controlling the pandemic. |
|
|
Owusu, D, Kim, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Among 513 adults aged 18–49 years without underlying medical conditions hospitalized with COVID-19 during March–August
2020, 22% were admitted to intensive care unit; 10% required mechanical ventilation; and three patients died (0.6%). These data demonstrate that healthy younger adults can develop severe COVID-19. |
|
|
COVID-19 Pandemic and Thalassemia Major Patients: Transfusion Practice and Treatment Assessment |
Oymak, Y, Karapinar, et al |
J Pediatr Hematol Oncol |
Healthcare Response | Réponse des soins de santé |
In this study, we aimed to investigate whether there were any differences in the follow-up and treatment of the patients
with TM during the outbreak. 61 patients with TM (32 males/29 females, mean age 13.9±6.8 y) were evaluated. The mean pretransfusion hemoglobin value was 9.14±0.77 g/dL and 8.87± 0.80 g/dL before and during the pandemic, respectively (P=0.023). There was no
difference between before and during the pandemic concerning transfusion interval and transfusion volume. However, SF levels increased above 1000 ng/mL in 16.6% of patients. |
|
COVID-19 Cough Classification using Machine Learning and Global Smartphone Recordings |
Pahar, Madhurananda, Klopper, et al |
arXiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We present a machine learning based COVID-19 cough classifier which is able to discriminate COVID-19 positive coughs
from both COVID-19 negative and healthy coughs recorded on a smartphone. This type of screening is non-contact and easily applied, and could help reduce workload in testing centers as well as limit transmission by recommending early self-isolation to those
who have a cough suggestive of COVID-19. Our results show that the Resnet50 classifier was best able to discriminate between the COVID-19 positive and the healthy coughs with an area under the ROC curve (AUC) of 0.98 while a LSTM classifier was best able to
discriminate between the COVID-19 positive and COVID-19 negative coughs with an AUC of 0.94. |
|
Panda, K, Alagarasu, et al |
Indian J Med Res |
Coronavirology| Coronavirologie |
Abstract and full text not available. |
|
|
Paulino-Ramirez, R, Báez, et al |
Am J Trop Med Hyg |
Epidemiology| Épidémiologie Immunology | Immunologie |
This study aimed to understand the distribution of IgM and IgG antibodies within the Dominican Republic during community-based
interventions. To achieve this, we analyzed the demographic characteristics of participants who received a SARS-CoV-2 IgM/IgG rapid test in emerging hotspots within the Dominican Republic. |
|
|
Perez, S, Innes, et al |
MMWR Morb Mortal Wkly Rep |
Healthcare Response | Réponse des soins de santé |
A New Jersey hospital reported a cluster of 34 CRAB cases that peaked during a surge in COVID-19 hospitalizations.
Strategies to preserve continuity of care led to deviations in IPC practices; CRAB cases decreased when normal operations resumed. |
|
|
Pierrotti, LC, Reusing Junior, et al |
Transplant International |
Clinical data| Données cliniques |
We present a retrospective description of 51 kidney transplant recipients (KTR) with confirmed moderate‐to‐severe COVID‐19
pneumonia both through positive real‐time reverse transcription–polymerase chain reaction (rRT‐PCR) for SARS‐CoV‐2 in a respiratory specimen (n = 48 patients); or positive serology IgM and/or IgG (n = 3 patients). The patients were hospitalized in a tertiary
university public hospital in São Paulo metropolitan city and followed up to July 7, 2020. |
|
|
Web-Based Relaxation Intervention for Stress During Social Isolation: Randomized Controlled Trial |
Pizzoli, SFM, Marzorati, et al |
JMIR Ment Health |
Mental Health |
|
This randomized study aimed to test whether web-based relaxation practices like natural sounds, deep respiration, and
body scans can promote relaxation and a positive emotional state, and reduce psychomotor activation and preoccupation related to the COVID-19 pandemic. |
|
Podewils, LJ, Burket, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie |
In Denver, Colorado, the majority of adult COVID-19 cases (55%), hospitalizations (62%), and deaths (51%) were among
Hispanic adults, double the proportion of Hispanic adults in Denver (24.9%). Among adults with COVID-19, Hispanic persons reported larger household sizes and more known COVID-19 household exposure, working in essential industries, working while ill, and delays
in testing after symptom onset. |
|
|
Post, LA, Issa, et al |
J Med Internet Res |
Epidemiology| Épidémiologie Surveillance |
The aim of this study is to develop dynamic metrics for public health surveillance that can inform worldwide COVID-19
prevention efforts. As the United States enters its third wave of COVID-19, all 50 states and the District of Colombia have positive rates of speed between 7.58 (Hawaii) and 175.01 (North Dakota), and persistence, ranging from 4.44 (Vermont) to 195.35 (North
Dakota) new infections per 100,000 people. |
|
|
Pothineni, NVK, Starkey, et al |
Circ Cardiovasc Interv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We report the results of testing for a 4-week period and describe results of patient and HCP surveys regarding their
perceptions on universal testing. |
|
|
Prado, NMBL, Rossi, et al |
Cadernos de saude publica |
Healthcare Response | Réponse des soins de santé |
This study examines the primary health care (PHC) organization in response to the COVID-19 epidemic. This is a descriptive
study based on the document analysis of the countries’ responses to the coronavirus pandemic with emphasis on PHC. In various countries, there have been different organizations and impacts of strategies since they have conducted actions according to the local
characteristics of disease transmission, demography, public health services organization, and health system’s capacity and financing, especially in the PHC area. A significant change during the pandemic has been the increase in telephone and video consultations
incorporating health information technology. An efficient PHC, guided by essential actions, achieves more suitable results. Also, each country’s cumulative capacity or experience makes the difference facing the emerging demands on different health systems. |
|
|
Probst, TM, Lee, et al |
J Appl Psychol |
Public Health response| Interventions de santé publique |
The Centers for Disease Control and Prevention (CDC) has developed a list of recommended preventative health behaviors
for Americans to enact, including social distancing, frequent handwashing, and limiting nonessential trips from home. Drawing upon scarcity theory, the purpose of this study was to examine whether the economic stressors of perceived job insecurity and perceived
financial insecurity are related to employee self-reports of enacting such behaviors. working in a state with more extensive COVID-19 restrictions seemed to primarily benefit more financially secure workers. When statewide policies were more restrictive, employees
reporting more financial security were more likely to enact the CDC-recommended guidelines compared to their financially insecure counterparts. |
|
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PMC7314154; Age-dependent Gender Differences in COVID-19 in Mainland China: Comparative Study |
Qian, J, Zhao, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie |
We used the national surveillance database of COVID-19 in mainland China to compare gender differences in attack rate
(AR), proportion of severe and critical cases (PSCC), and case fatality rate (CFR) in relation to age, affected province, and onset-to-diagnosis interval. We elucidate an age-dependent gender dimorphism for COVID-19, in which females have higher susceptibility
but lower severity and fatality. |
|
Fatal outcome of anti-MDA5 juvenile dermatomyositis in a paediatric COVID-19 patient: a case
report |
Quintana-Ortega, C, Remesal, et al |
Mod Rheumatol Case Rep |
Clinical data| Données cliniques |
Anti-melanoma differentiation-associated gene 5 juvenile dermatomyositis (anti-MDA5 JDM) is associated with high risk
of developing rapidly progressive interstitial lung disease (RP-ILD). Here we report an 11-year-old girl with anti-MDA5 JDM and RP-ILD which led to a fatal outcome, further aggravated by SARS-CoV-2 infection. |
|
Rahman, SMM, Akter, et al |
Bangladesh Medical Research Council bulletin |
Public Health response| Interventions de santé publique |
The cross-sectional study was aimed to determine the knowledge levels, attitudes and practices towards the COVID-19
among the Bangladeshi population. The lowest level of knowledge prevailed among the above 50 years’ age group regarding the disease, which was higher among female, and more among the respondents having education level below graduation. Of the total respondents,
73.5% had negative attitude towards use of face mask. Only 52.1% used face masks and 51.8% practiced hand washing. More than 70.0% respondents had knowledge on social distancing, but only 50.0% were practicing it. Male respondents had 1.5 times more knowledge
about the social distancing than the female counterpart |
|
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A 23-Year-Old Man With Multisystem Inflammatory Syndrome After Mild COVID-19 |
Razavi, AC, Chang, et al |
Journal of Investigative Medicine High Impact Case Reports |
Clinical data| Données cliniques |
We present the case of a young obese patient with recent COVID-19 who developed multisystem inflammatory syndrome (MIS)
1 month after spontaneous resolution. The patient was empirically treated for MIS with intravenous immunoglobulin and methylprednisolone, which led to a rapid resolution of fever and laboratory abnormalities. |
|
Recinella, G, Marasco, et al |
Gerontology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to evaluate the diagnostic and prognostic role of lung ultrasound (LUS) in elderly patients
hospitalized for SARS-CoV-2 pneumonia. Thirty-seven hospitalized elderly patients with a diagnosis of SARS-CoV-2 infection were consecutively enrolled. Ultrasound alterations were found in all patients enrolled; inhomogeneous interstitial syndrome with spared
areas (91.9%) and pleural alterations (100%) were the most frequent findings. At multivariate analysis, only LUS score was independently associated with in-hospital death. The LUS score's best cutoff for distinguishing patients experiencing in-hospital death
was 17 . |
|
|
Riebeling, T, Jamal, et al |
Cell Death Differ |
Clinical data| Données cliniques Therapeutics| Thérapeutique Animal model | Modèle
animal |
The receptor-interacting serine/threonine protein kinase 1 (RIPK1) is a key mediator of regulated cell death and inflammation.
We searched for a RIPK1 inhibitor and present the aromatic antiepileptic and FDA-approved drug primidone (Liskantin®) as a potent inhibitor of RIPK1 activation in vitro and in a murine model of TNFα-induced shock, which mimics the hyperinflammatory state of
cytokine release syndrome. Furthermore, we detected for the first time RIPK1 activation in the respiratory tract epithelium of hospitalized patients who tested positive for SARS-CoV-2 infection. |
|
|
RISk, Covid-, Treatments, et al |
Vascular pharmacology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The hypothesis that been set forward that use of Renin Angiotensin Aldosterone System (RAAS) inhibitors is associated
with COVID-19 severity. RESULTS: Out of 4069 COVID-19 patients, 13.5% and 13.3% received ACE-I or ARB, respectively. Use of neither ACE-I nor ARB was associated with mortality. Findings were similar restricting the analysis to hypertensive patients or when
ACE-I or ARB were considered as a single group. |
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Clinicians, cooks, and cashiers: Examining health equity and the COVID-19 risks to essential workers |
Roberts, JD, Dickinson, et al |
Toxicology and industrial health |
Public Health response| Interventions de santé publique |
To assess the various impacts of COVID-19 on essential workers (EWs), an online survey was distributed to a representative
sample of individuals residing in six states during May/June 2020. We assessed differences between EW and non-essential worker (NW) respondents. EWs were more likely to be Black or Hispanic than NWs and also had lower incomes and education levels on average.
Unsurprisingly, EWs were substantially more likely to report working outside the home and less likely to report social distancing and wearing masks indoors as compared to NWs. EWs also perceived a slightly greater risk of contracting COVID-19. |
|
Rocheleau, Lynda, Laroche, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We profiled intra-sample genetic diversity of SARS-CoV-2 variants using 15,289 high-throughput sequencing datasets
from infected individuals and infected cell lines. Despite high mutational background, we confidently identified intra-variable positions recurrent in the samples analyzed, including several positions at the end of the gene encoding the viral S protein. Notably,
most of the samples possesses a C->A missense mutation resulting in the S protein lacking the last 20 amino acids (SΔ20). Here we demonstrate that SΔ20 exhibits increased cell-to-cell fusion and syncytia formations. Our findings are suggestive of the consistent
emergence of high-frequency viral quasispecies that are not horizontally transmitted but involved in intra-host infection and spread. |
|
|
Rossetti, GiacomoG, Ossorio, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Mpro, also known as 3CLpro, is the main protease of the SARS-CoV-2 coronavirus and, as such, is essential for the viral
life cycle. Two clusters of chemical compounds with Mpro inhibitory activity were identified. The study of the analogues revealed that the compounds of the first cluster acted by denaturing Mpro and might denature other proteins as well. In contrast, the compounds
of the second cluster targeted Mpro with much greater specificity and enhanced its melting temperature, consistent with the formation of stable Mpro-inhibitor complexes. The most active compounds of the second cluster exhibited IC50 values between 4 and 7
μM and their chemical structure suggests that they could serve as leads for the development of potent Mpro inhibitors. |
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Radiology imaging management in an Italian cancer center (IRST IRCCS) during the COVID-19 pandemic |
Rossi, A, Prochowski Iamurri, et al |
Insights Imaging |
Healthcare Response | Réponse des soins de santé |
We reorganized the daily routine of our cancer center to reduce the risk of contagion. A temporary tensile structure
was set up as an entry-point triage, and a COVID-19 route was created with a dedicated CT scanner. A pre-access telephonic triage was performed the day before a patient was scheduled to come in for an examination. At the time of writing (May 4), 4053 patients
had been to our center since the emergency officially began and the COVID-19 route had been activated for only 9 paucisymptomatic outpatients and 7 symptomatic inpatients. We also re-evaluated patient radiology examination lists and rescheduled non-urgent
tests in consensus with the referring oncologist. |
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Delirium: Clinical Presentation and Outcomes in Older COVID-19 Patients |
Rozzini, R, Bianchetti, et al |
Frontiers in Psychiatry |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of the study is to describe the clinical characteristics and outcomes of a series of older patients consecutively
admitted into a non-ICU ward due to SARS-CoV-2 infection, developing delirium. Hypokinetic delirium with lethargy and confusion was observed in 43% of cases (6/14 patients). A total of eight patients exhibited hyperkinetic delirium and 50% of these patients
(4/8) died. The overall mortality rate was 71% (10/14 patients). Among the four survivors we observed two different clinical patterns: two patients exhibited dementia and no ARDS (acute respiratory distress syndrome), while the remaining two patients exhibited
ARDS and no dementia. |
|
Saeed, M, Saeed, et al |
Molecules |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, we performed a combination of multiscoring virtual screening and molecular docking of a library of 1624 natural
compounds on the active sites of the SARS-CoV-2 Endoribonuclease, NSP15. Top-ranked compounds NuBBE-1970 and NuBBE-242 were further investigated via an indepth molecular-docking and molecular-dynamics simulation of 60 ns, which revealed that the binding of
these two compounds with active site residues of NSP15 was sufficiently strong and stable. |
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Analysis of COVID-19 Cases' Spatial Dependence in US Counties Reveals Health Inequalities |
Saffary, T, Adegboye, et al |
Frontiers in Public Health |
Epidemiology| Épidémiologie |
Here, we discuss the spatial correlation between county population health rankings and the incidence of COVID-19 cases
and COVID-19 related deaths in the United States. There was significant positive global spatial correlation between the percentage of Black Americans and cases of COVID-19. A similar result was found for the global spatial correlation between the percentage
of Black American and deaths due to COVID-19 at the county level in the U.S. There was no significant spatial correlation between the Hispanic population and COVID-19 cases and deaths; however, a higher percentage of non-Hispanic white was significantly negatively
spatially correlated with cases and deaths from the disease. |
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Population Difference in Allele Frequency of HLA-C*05 and Its Correlation with COVID-19 Mortality |
Sakuraba, A, Haider, et al |
Viruses |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In the present study, we investigated the association between human leukocyte antigen (HLA) class I, which plays a
major role in susceptibility to viral infections, and the mortality of COVID-19. We demonstrated that allele frequency of HLA-C*05 and the distribution pattern with its receptor KIR2DS4fl strongly correlated with COVID-19 mortality. |
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Sarpong, K, Dowlati, et al |
World Neurosurg |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
We aim to evaluate neurosurgical practice patterns as well as perioperative incidence of COVID-19 in neurosurgical
patients and their outcomes. A significant increase in elective case volume during the post-peak pandemic period is feasible with low and acceptable incidence of COVID-19 in neurosurgical patients. COVID-19 positive patients were younger, less likely to undergo
elective procedures, had increased length of stay, had more complications, and were discharged to a location other than home. The modified Medically Necessary Time Sensitive score plays a role in decision making for scheduling elective cases. |
|
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Savita, S, Mishra, et al |
Biochemical and Cellular Archives |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study introduces natural origin products as alternative therapies. SARS-COV-2 consist the main protease protein
PDBID: 6LU7, which plays a potential role in COVID-19 viral replication. Results of molecular docking simulation with 6LU7 and its structurally modified compounds revealed that Bet (A8) was better binding affinity (-11.53 Kcal/mol) among all modifications
including pure Bet A. Despite this the most recommended potential inhibitors of COVID-19 main protease were Bet (A3) and Bet (A4). |
|
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Sawalha, K, Adeodokun, et al |
Journal of Investigative Medicine High Impact Case Reports |
Clinical data| Données cliniques |
A 44-year-old male patient with no past medical history presented 2 weeks after seropositive coronavirus disease 2019
(COVID-19) infection with vision problems suggestive of optic neuritis. Radiological testing showed findings suspicious for acute bilateral optic neuritis. The patient had also anti-MOG antibodies. Whether this was an optic neuritis due to COVID-19, MOG antibody
disease, or an activation of MOG antibody disease by COVID-19 is discussed in this case. |
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Schapkaitz, E, De Jager, et al |
Int J Lab Hematol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aims to describe the characteristic peripheral blood morphological features associated with COVID‐19 infection
in a resource‐limited setting in South Africa. The study consisted of a cohort of 102 patients of whom 25 (24.5%) were admitted to the intensive care unit (ICU). A lymphopenia was seen in 49 (48.0%) patients, with a severe lymphopenia in 19 (18.6%). In the
subgroup of HIV‐infected patients, no significant difference in the median absolute lymphocyte count relative to uninfected patients was observed. On PBS examination, atypical lymphocytes, which are well described in the setting of viral infections, were observed
in 59 (57.8%) patients. |
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COVID-19 lockdown induces disease-mitigating structural changes in mobility networks |
Schlosser, F, Maier, et al |
Proc Natl Acad Sci U S A |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
Here we use movement data of mobile phone users to show that mobility in Germany has not only been reduced considerably:
Lockdown measures caused substantial and long-lasting structural changes in the mobility network. We find that long-distance travel was reduced disproportionately strongly. Using a SIR mode, we demonstrate that these structural changes have a considerable
effect on epidemic spreading processes by "flattening" the epidemic curve and delaying the spread to geographically distant regions. |
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Schwab, K, Hamidi, et al |
Open Forum Infectious Diseases |
Clinical data| Données cliniques |
We report a case of a 34-year-old with COVID-19 pneumonia receiving an Interleukin-6 blockade (IL-6) receptor antagonist
(IL-6Ra) who developed spontaneous colonic perforation. Examination of the colon by electron microscopy revealed numerous intact severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions abutting the microvilli of the colonic mucosa. Multiplex immunofluorescent
staining revealed the presence of the SARS-CoV-2 spike protein on the brush borders of colonic enterocytes that expressed angiotensin-converting enzyme 2. |
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Sehra, ST, Salciccioli, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Transmission |
In this study, we analyzed case data from the United States to investigate the effects of temperature, precipitation,
and ultraviolet (UV) light on community transmission of SARS-CoV-2. Daily reported cases of SARS-CoV-2 across the United States from 22 January 2020 to 3 April 2020 were analyzed. A maximum temperature above 52°F on a given day was associated with a lower
rate of new cases at 5 days (incidence rate ratio IRR], 0.85 0.76, 0.96]; P = .009). Among observations with daily temperatures below 52°F, there was a significant inverse association between the maximum daily temperature and the rate of cases at 5 days (IRR,
0.98 0.97, 0.99]; P = .001). A 1-unit higher UV index was associated with a lower rate at 5 days (IRR, 0.97 0.95, 0.99]; P = .004). Precipitation was not associated with a greater rate of cases at 5 days (IRR, 0.98 0.89, 1.08]; P = .65). The incidence of disease
declines with increasing temperature up to 52°F and is lower at warmer vs cooler temperatures. However, the association between temperature and transmission is small. |
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Selby, K, Durand, et al |
JMIR Form Res |
Public Health response| Interventions de santé publique |
The aim was to assess citizens' knowledge and perceptions about COVID-19 recommendations in the Canton of Vaud, Switzerland.
Mean levels of worry about the COVID-19 pandemic were higher in women than men (55/100 versus 44/100, P<.001), and in respondents with lower health literacy (57/100 versus 52/100, P=.03). Self-reported adherence to recommendations was high (85%) and increased
with age and worry (both P<.001). Moreover, 34% of respondents reported having self-quarantined; this rose to 52% for those aged ≥75 years. Nearly half (49%) of respondents felt the government response had been adequate, though younger age and higher levels
of worry were associated with considering the response to be insufficient (both P<.001). |
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Selvaraj, D, Venkatesan, et al |
International Journal of Imaging Systems and Technology |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This paper propose a deep neural network (DNN) model trained on a limited dataset where features are selected using
a region-specific approach. Specifically, we apply the Zernike moment (ZM) and gray level co-occurrence matrix (GLCM) to extract the unique shape and texture features. The feature vectors computed from these techniques enable segmentation that illustrates
the severity of the COVID-19 infection. The proposed algorithm was compared with other existing state-of-the-art deep neural networks using the Radiopedia and COVID-19 CT Segmentation datasets presented specificity, sensitivity, sensitivity, mean absolute
error (MAE), enhance-alignment measure (EMφ), and structure measure (Sm) of 0.942, 0.701, 0.082, 0.867, and 0.783, respectively. |
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A prospective study of 12-week respiratory outcomes in COVID-19-related hospitalisations |
Shah, AS, Wong, et al |
Thorax |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The long-term respiratory morbidity of COVID-19 remains unclear. We describe the clinical, radiological and pulmonary
function abnormalities that persist in previously hospitalised patients assessed 12 weeks after COVID-19 symptom onset, and identify clinical predictors of respiratory outcomes. At least one pulmonary function variable was abnormal in 58% of patients and 88%
had abnormal imaging on chest CT. There was strong association between days on oxygen supplementation during the acute phase of COVID-19 and both DLCO-% (diffusion capacity of the lung for carbon monoxide) predicted and total CT score. These findings highlight
the need to develop treatment strategies and the importance of long-term respiratory follow-up after hospitalisation for COVID-19. |
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Shahbaz, Sumbal, Ashraf, et al |
Research Square prepub |
Mental Health |
|
This study aims to discover the psychosocial challenges faced by female health care professionals (HCPs) treating COVID-19
patients in Pakistan. Using an empirical phenomenological methodology, semi-structured telephone-based qualitative interviews were taken from 22 female HCPs who were providing their expertise for COVID-19 patients in tertiary level hospitals of Lahore, Pakistan.
Five themes have been observed in the interviews: psychological concerns of HCPs while treating COVID-19 patients; feelings towards COVID-19 patients; confidence in government, administration and self-reflection; challenges as female HCPs and coping strategies;
and finally, future concerns and recommendations. Many of these themes have also been linked with cultural issues, making the results specific for Pakistan. During the COVID-19 pandemic, female front-line HCPs have faced immense psychosocial pressure, starting
from unsupportive family norms to unwelcoming working environment and insensitive hospital administration. |
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Shurlock, J, Rudd, et al |
Int J Qual Health Care |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to assess the utility and frequency of use of the Nightingale Communication method, during
the early operational phase of the Nightingale Hospital London 4000-bed field hospital Intensive Care Unit. Staff working in the clinical area, and therefore requiring full personal protective equipment, of the ICU at Nighingale London hospital were administered
a cross-sectional assesment survey. 50 valid responses were received (72% response rate) covering all clinical professional groups. Prominent name/role identifications and colour-coded identification tapes were very frequently used and were perceived as being
highly useful. Formal hand signals were infrequently used, and not perceived as being beneficial, with respondents citing use of single taught gestures only in specific circumstances. PPE is highly depersonalising and interpersonal identification aids are
very useful. Despite being difficult, verbal communication is not completely prohibited, which could explain the low utility of formal hand signals. The methods developed at the Nightingale hospital have enhanced communication in the critical care, field hospital
setting. |
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Si, Mingyu, Xiao, et al |
Research Square prepub |
Mental Health |
|
This study aims to explore the efficacy and possible mechanism of a Mindful Living With Challenge (MLWC) intervention
designed for Chinese COVID-19 survivors in alleviating their psychological problems caused by both the disease and the pandemic. This study is a protocol for a randomized controlled trial. More than 1600 eligible participants will be assigned 1:1 to an online
MLWC intervention group or a waitlist control group. All participants will be asked to complete online questionnaires at baseline , post-program, and 3-month follow-up. The primary outcome is mental health status which includes PTSD and other psychological
symptoms (i.e. depression, anxiety). The secondary outcomes are related physical symptoms including fatigue and sleeplessness assessed by verified scales such as the Fatigue Scale-14, Pittsburgh Sleep Quality Index. |
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Silva de Souza, A, Rivera, et al |
J Phys Chem Lett |
Coronavirology| Coronavirologie |
As initial steps leading to virus entry involve significant changes in protein conformation as well as in the electrostatic
environment in the vicinity of the Spike/hACE-2 complex, we explored the sensitivity of the interaction to changes in ionic strength through computational simulations and surface plasmon resonance. We identified two regions in the receptor-binding domain (RBD),
E1 and E2, which interact differently with hACE-2. At high salt concentration, E2-mediated interactions are weakened but are compensated by strengthening E1-mediated hydrophobic interactions. These results provide a detailed molecular understanding of Spike
RBD/hACE-2 complex formation and stability under a wide range of ionic strengths. |
|
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Silva, Mirela, Ceschin, et al |
arXiv |
Public Health response| Interventions de santé publique |
In this paper, we examine nearly 505K COVID-19-related tweets from the initial months of the pandemic to understand
misinformation as a function of bot-behavior and engagement. Using a correlation-based feature selection method, we selected the 11 most relevant feature subsets among over 170 features to distinguish misinformation from facts, and to predict highly engaging
misinformation tweets about COVID-19. We achieved an average F-score of at least 72\% with ten popular multi-class classifiers, reinforcing the relevance of the selected features. We found that (i) real users tweet both facts and misinformation, while bots
tweet proportionally more misinformation; (ii) misinformation tweets were less engaging than facts; (iii) the textual content of a tweet was the most important to distinguish fact from misinformation while (iv) user account metadata and human-like activity
were most important to predict high engagement in factual and misinformation tweets; and (v) sentiment features were not relevant. |
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COVID-19 Contact Tracing and Privacy: A Longitudinal Study of Public Opinion |
Simko, Lucy, Chang, et al |
arXiv |
Public Health response| Interventions de santé publique |
There has been significant public discussion about the tensions between effective technology-based contact tracing
and the privacy of individuals. To inform this discussion, we present the results of seven months of online surveys focused on contact tracing and privacy, each with 100 participants. Our first surveys were on April 1 and 3, before the first peak of the virus
in the US, and we continued to conduct the surveys weekly for 10 weeks (through June), and then fortnightly through November, adding topical questions to reflect current discussions about contact tracing and COVID-19. Our results present the diversity of public
opinion and can inform policy makers, technologists, researchers, and public health experts on whether and how to leverage technology to reduce the spread of COVID-19, while considering potential privacy concerns. |
|
Sivaramakrishnan, Gowri, Alsobaiei, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to identify the prescription and drug utilization of primary care dental practitioners during
the temporary suspension of routine dental practices due to COVID-19. Anonymized data from out-patient dental prescriptions from February 2020 to August 2020 were collected. n average of two medications were prescribed for each patient, that included systemic
and local analgesics and anti-microbials. 33.4% of patients were only prescribed medications without any dental intervention. Approximately 35% of the records showed inappropriate diagnosis and their rationale for prescription could not be determined. Amoxicillin
and amoxicillin/clavulanic acid amongst the antimicrobial class; and ibuprofen and acetaminophen amongst the analgesics accounted for 90% of prescribed drugs. Chlorhexidine mouth rinse seemed to be on the regular list for any diagnoses, prescribed between
7 and 14 days, twice or thrice daily. Suspension of dental practices can cause more harm in terms of overuse and unindicated prescription practices in primary dental care. The awareness of the recent guidelines is important to prevent unintended use. |
|
|
Skolmowska, D, Głąbska, et al |
Pathogens |
Public Health response| Interventions de santé publique Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI) |
The aim of the study was to analyze hand hygiene behaviors in a national representative sample of Polish adolescents
in regions stratified by COVID-19 morbidity, while taking socioeconomic status of the region, as well rural or urban environment, into account as possible interfering factors. In regions of low COVID-19 morbidity, a higher share of adolescents, than in regions
of high morbidity, declared washing their hands before meals (p = 0.0196), after meals (p = 0.0041), after preparing meals (p = 0.0297), before using the restroom (p = 0.0068), after using the restroom (p = 0.0014), after combing their hair (p = 0.0298), after
handshaking (p = 0.0373), after touching animals (p = 0.0007), after contacting babies (p = 0.0278), after blowing nose (p = 0.0435), after touching sick people (p = 0.0351), and after cleaning home (p = 0.0234). |
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Designing a Prospective COVID-19 Therapeutic with Reinforcement Learning |
Skwark, MarcinJ, Carranza, et al |
arXiv |
Coronavirology| Coronavirologie |
Here we formulate a novel protein design framework as a reinforcement learning problem. We generate new designs efficiently
through the combination of a fast, biologically-grounded reward function and sequential action-space formulation. The use of Policy Gradients reduces the compute budget needed to reach consistent, high-quality designs by at least an order of magnitude compared
to standard methods. Complexes designed by this method have been validated by molecular dynamics simulations, confirming their increased stability. This suggests that combining leading protein design methods with modern deep reinforcement learning is a viable
path for discovering a Covid-19 cure and may accelerate design of peptide-based therapeutics for other diseases. |
|
Socolovithc, RL, Fumis, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to describe the clinical outcomes of critically ill COVID-19 patients and assess the impact on the use of
hospital resources and compare with critically ill medical patients without COVID-19. In this retrospective cohort study, we included patients diagnosed with COVID-19 admitted to a private ICU in Sao Paulo, Brazil from March to June 2020. We compared these
patients with those admitted to the unit in the same period of the previous year. A total of 212 consecutive patients with a confirmed diagnosis of COVID-19 were compared with 185 medical patients from the previous year. Patients with COVID-19 were more frequently
males (76% vs. 56%, p<0.001) and morbidly obese (7.5% vs. 2.2%, p = 0.027), and had lower SAPS 3 (49.65 (12.19) vs. 55.63 (11.94), p<0.001) and SOFA scores (3.78 (3.53) vs. 4.48 (3.11), p = 0.039). After multivariable adjustment for age, gender, SAPS 3, and
Charlson Comorbidity Index, COVID-19 remained not associated with survival at 28 days (HR 0.59, 95% CI 0.33-1.06, p = 0.076). COVID-19 required more hospital resources, including invasive and non-invasive ventilation, had a longer duration of mechanical ventilation,
and a more prolonged ICU and hospital length of stay. |
|
|
Sonnino, Giorgio, Mora, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
We propose two stochastic models for the Coronavirus pandemic. The statistical properties of the models, in particular
the correlation functions and the probability density function, have duly been computed. Our models, which generalises a model previously proposed and published in a specialised journal, take into account the adoption of the lockdown measures as well as the
crucial role of the hospitals and Health Care Institutes. We show that in the case of the pure SIS-model, once the lockdown measures are removed, the Coronavirus will start growing again. However, in the second scenario, beyond a certain threshold of the hospital
capacities, the Coronavirus is not only kept under control, but its capacity to spread tends to diminish in time. Therefore, the combined effect of the lockdown measures with the action of the hospitals and health Institutes is able to contain and dampen the
spread of the SARS-CoV-2 epidemic. |
|
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Stavem, K, Ghanima, et al |
Thorax |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study assessed symptoms and their determinants 1.5-6 months after symptom onset in non-hospitalised subjects with
confirmed COVID-19 until 1 June 2020, in a geographically defined area. We invited 938 subjects; 451 (48%) responded. They reported less symptoms after 1.5-6 months than during COVID-19; median (IQR) 0 (0-2) versus 8 (6-11), respectively (p<0.001); 53% of
women and 67% of men were symptom free, while 16% reported dyspnoea, 12% loss/disturbance of smell, and 10% loss/disturbance of taste. In multivariable analysis, having persistent symptoms was associated with the number of comorbidities and number of symptoms
during the acute COVID-19 phase. |
|
|
Stolyarevich, ES, Frolova, et al |
Nephrology and Dialysis |
Clinical data| Données cliniques |
Investigated the incidence, causes and nature of kidney damage in patients with COVID-19. Th e data obtained from 220
patients, died from COVID-19 between April 20 and May 20, 2020. At the time of hospitalization, 55 (25%) patients had features of chronic kidney disease (CKD). Acute kidney injury (AKI) developed in 135 patients (61%). Pathologic examination revealed preexisting
renal pathology in 76 patients (43%), including 34 out of 55 (62%) patients who had a decrease in glomerular filtration rate (GFR) at the time of hospitalization, and in 40 out of 165 (24%) patients who had normal kidney function at admission (P<0.01). |
|
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The COVID-19 pandemic: impact on surgical departments of non-university hospitals |
Stöß, C, Steffani, et al |
BMC Surg |
Healthcare Response | Réponse des soins de santé |
Analyzed the effects of COVID-19 on surgical care in non-university hospitals in Germany. Communication and cooperation
with authorities, hospital administration and other departments were largely considered sufficient. In the early phase of the COVID-19 pandemic, 28.4% of the respondents complained about a short supply of protective equipment available for the hospital staff.
7.4% of the participants stated that emergency operations had to be postponed or rescheduled. A decreased quantity of emergency surgical procedures and a decreased number of surgical emergency patients treated in the emergency room was reported in 43.9% and
63.5%, respectively. Consultation and treatment of oncological patients in the outpatient clinic was decreased in 54.1% of the surveyed hospitals. To increase the capacity for COVID-19 patients, a reduction of bed and operating room occupancy of 50.8 ± 19.3%
and 54.2 ± 19.1% were reported, respectively. Therefore, 90.5% of all participants expected a loss of revenue of 28.2 ± 12.9% in 2020. |
|
Sun, C, Li, et al |
Leuk Lymphoma |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Designed and conducted a cross-sectional survey in Hubei province to explore the prevalence and clinical features of
COVID-19 in multiple myeloma (MM) patients during the pandemic. In our study, the incidence of COVID-19 in MM patients was 1.57%, relatively higher than the reported 0.11% in the general population by 19 April 2020. This is consistent with a nationwide survey
in China which shows that cancer patients are more susceptible to SARS-CoV-2 infection. Among these five patients with COVID-19, four of then were in infected in hospital, three in the process of active treatment for MM. |
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Forecasting the long-term trend of COVID-19 epidemic using a dynamic model |
Sun, J, Chen, et al |
Sci Rep |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Propose a new model named Dynamic-Susceptible-Exposed-Infective-Quarantined (D-SEIQ), by making appropriate modifications
of the Susceptible-Exposed-Infective-Recovered (SEIR) model and integrating machine learning based parameter optimization under epidemiological rational constraints. We used the model to predict the long-term reported cumulative numbers of COVID-19 cases in
China from January 27, 2020.In China-Excluding-Hubei area within 7 days after the first public report, our model successfully and accurately predicted the long trend up to 40 days and the exact date of the outbreak peak. The predicted cumulative number (12,506)
by March 10, 2020, was only 3·8% different from the actual number (13,005). |
|
Suppan, M, Catho, et al |
JMIR Serious Games |
Healthcare Response | Réponse des soins de santé |
Developed a serious game that would promote IPC practices with a specific focus on COVID-19 among HCWs and other hospital
employees. The game was designed to target all hospital staff who could be in direct contact with patients within the Geneva University Hospitals. In total, 10 acquisition objectives were defined by IPC specialists and implemented into the game according to
the principles of meaningful gamification. A simple storyboard was first created using Microsoft PowerPoint and was progressively refined through multiple iteration loops. Articulate Storyline was then used to create two successive versions of the actual game.
In the final version, a unique graphic atmosphere was created with help from a professional graphic designer. Feedback mechanisms were used extensively throughout the game to strengthen key IPC messages. |
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Swaminathan, R, Mukundadura, et al |
Postgrad Med J |
Mental Health |
|
Describe the impact on the physical and mental well-being of healthcare professionals who use enhanced PPE consistently.
Prospective analysis of the views of 72 respondents is reported. 63.9% were women and 36.1% were men. Physical impact included exhaustion, headache, skin changes, breathlessness and a negative impact on vision. Communication difficulties, somnolence, negative
impact on overall performance and difficulties in using surgical instrumentation were reported. |
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COVID-19 public health measures: a reduction in hospital admissions for COPD exacerbations |
Tan, JY, Conceicao, et al |
Thorax |
Healthcare Response | Réponse des soins de santé |
In this study, we report a significant and sustained decrease in hospital admissions for all AECOPD as well as RVI-associated
AECOPD, which coincided with the introduction of public health measures during the COVID-19 pandemic. |
|
Tan, LL, Pillay, et al |
Annals of the Academy of Medicine, Singapore |
Healthcare Response | Réponse des soins de santé |
Share a proof of concept study, which comprised of the demographics of the first 15 patients, protocol and feedback
from patients, caregivers and the healthcare professionals (HCPs) involved. A total of 15 patients were seen by two geriatricians with Tele-SOC. Their age, gender and race were typical of a geriatric population. All patients had their issues addressed and
managed during the Tele-SOC consultations and none of the patients required an earlier physical review. All patients needed caregivers to set up the video conferencing application to participate in the Tele-SOC consultations. Majority of the caregivers were
children of the patients. There was no technical issue encountered for all patients. The duration of the teleconsultation ranged from 7 minutes to 89 minutes, with an average time of 39.4 minutes, which was slightly longer compared to a typical clinic slot
of 30 minutes. |
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COVID-19 Australia: Epidemiology Report 29: Fortnightly reporting period ending 8 November 2020 |
Team, Covid- National Incident Room Surveillance |
Communicable diseases intelligence (2018) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Nationally, there was a continuing downward trend in notifications of COVID-19. The daily average number of cases for
this reporting period was nine, compared to an average of 14 cases per day in the previous fortnight. There were 123 cases of COVID-19 and two deaths this fortnight, bringing the cumulative case count to 27,743 and 904 deaths. New South Wales reported the
highest proportion of cases this fortnight (56%; 69/123), the majority of which were overseas acquired (54). Locally-acquired cases accounted for 15% (18/123) of all cases reported this fortnight. |
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Teamah, AAM, Afifi, et al |
Journal of Statistics Applications and Probability |
Coronavirology| Coronavirologie |
In this paper, we subedit a search for a randomly moving Coronavirus (COVID-19) among a finite set of different states.
We use a monitoring system to search for COVID-19 which is hidden in one of the n cells of the respiratory system in the human body in each fixed number of time intervals m. The expected rescue time of the patient and detecting COVID-19 has been obtained.
Also, we extend the results and obtain the total optimal expected search time of COVID-19. The optimal search strategy is derived suing a dynamic programming algorithm. An illustrative real life example introduced to clear the applicability of this model.
© 2020 Natural Sciences Publishing. All rights reserved. |
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Temiz, SA, Durmaz, et al |
Dermatol Ther |
Mental Health |
|
Examined the moods such as anxiety, fear and depression experienced by the patients during their application to the
cosmetology unit during the COVID-19 pandemic process and to compare them with the control group. A total of 162 cases, 80 cases from the cosmetology unit meeting the specified conditions and 82 cases as the control group, were retrospectively evaluated. In
all participants, the Coronavirus Anxiety Scale (CAS) scores decreased significantly compared to the beginning of the pandemic (p=0.001). In the study, while depression (HAM-D) and general anxiety (HAM-A) were higher in the cosmetology group compared to the
control group (respectively p=0.049, p=0.001), there was no difference in coronavirus anxiety scores (CAS) (p=0.24). |
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Thacker, VivekV, Sharma, et al |
bioRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
Used a vascularised lung-on-chip model where, consistent with monoculture reports, low numbers of SARS-CoV-2 virions
are released apically from alveolar epithelial cells. However, rapid infection of the underlying endothelial layer leads to the generation of clusters of endothelial cells with low or no CD31 expression, a progressive loss of endothelial barrier integrity,
and a pro-coagulatory microenvironment. These morphological changes do not occur if these cells are exposed to the virus apically. Viral RNA persists in individual cells, which generates a response that is skewed towards NF-KB mediated inflammation, is typified
by IL-6 secretion even in the absence of immune cells, and is transient in epithelial cells but persistent in endothelial cells. Perfusion with Tocilizumab, an inhibitor of trans IL-6 signalling slows the loss of barrier integrity but does not prevent the
formation of endothelial cell clusters with reduced CD31 expression. |
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Thell, Rainer, Zimmermann, et al |
Research Square prepub |
Clinical data| Données cliniques |
We evaluated standard blood laboratory parameters of 655 COVID-19 patients suspected to be infected with SARS-CoV-2,
who underwent PCR testing in one of five hospitals in Vienna, Austria. Our findings suggest that especially leukopenia, eosinopenia, as well as elevated erythrocytes, hemoglobin, and ferritin are helpful to distinguish between COVID-19 positive and negative
tested patients. |
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Tito, Annalisa, Colantuono, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Uncovered the role of a pomegranate peel extract in attenuating the interaction between the SARS-CoV-2 Spike glycoprotein
and the human Angiotensin-Converting Enzyme 2 (ACE2) receptor, and in inhibiting the activity of the virus 3CL protease. Although further studies will be determinant to assess the efficacy of this extract in vivo, our results open up new promising opportunities
to employ natural extracts for the development of effective and innovative therapies in the fight against SARS-CoV-2. |
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Tiwari, V, Deyal, et al |
Frontiers in Physics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Use an improvised five compartment mathematical model (SEIRD) to investigate the progression of COVID-19 and predict
the epidemic peak under the impact of lockdown in India. The aim of this study is to provide a more precise prediction of epidemic peak and to evaluate the impact of lockdown on epidemic peak shift in India. The model predicts that the total number of COVID-19
active cases would be around 5.8 × 105 on August 15, 2020 under current circumstances. In addition, our study indicates the existence of under-reported cases i.e., 105 during the post-lockdown period in India. Consequently, this study suggests that a nationwide
public lockdown would lead to epidemic peak suppression in India. |
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Tocto-Erazo, M, Espíndola-Zepeda, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
Developed a mathematical model to evaluate the impacts of the lockdown implemented in Hermosillo, Mexico. Results showed
that a hypothetical delay of two weeks, on the lockdown measures, would result in an early acme around May 9 for hospitalization prevalence and an increase on cumulative deaths, 42 times higher by May 31, when compared to baseline. On the other hand, results
concerning relaxation dynamics showed that the acme levels depend on the proportion of people who gets back to daily activities as well as the individual behavior with respect to prevention measures. |
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Torkian, Samaneh, Kazemi, et al |
Research Square prepub |
Epidemiology| Épidémiologie |
Investigated the relation between COVID-19 incidence and mortality with development indexes in different regions of
the world. The highest and lowest incidence and mortality rates were in the AMRO and WPRO regions, respectively. The development indexes had no a significant linear correlation with COVID-19 incidence and mortality except in WPRO, where there was direct significant
correlation between life expectancy at birth and inequality adjusted life expectancy with COVID-19 incidence and mortality (P<0.05). |
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Toubiana, J, Levy, et al |
Euro Surveill |
Epidemiology| Épidémiologie |
We assessed the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and Kawasaki
disease (KD)-like multisystem inflammatory syndrome in a retrospective case-control study in France. RT-PCR and serological tests revealed SARS-CoV-2 infection in 17/23 cases vs 11/102 controls (matched odds ratio: 26.4; 95% confidence interval: 6.0-116.9),
indicating strong association between SARS-CoV-2 infection and KD-like illness. Clinicians should keep a high level of suspicion for KD-like illness during the COVID-19 pandemic. |
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Tverring, J, Åkesson, et al |
Trials |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé RCT |
We plan to perform an investigator-initiated, pragmatic, randomised trial at an intermediate-level COVID-19 cohort
ward in Helsingborg Hospital, southern Sweden. We have estimated a required sample size of 120 patients randomised 1:1 to HFNC or Helmet CPAP to achieve 90% power to detect superiority at a 0.05 significance level regarding the primary outcome of ventilator
free days (VFD) within 28 days using a Mann-Whitney U test. We hypothesise that the use of Helmet CPAP will reduce the need for invasive mechanical ventilation compared to the use of HFNC without having a negative effect on survival. This could have important
implications during the current COVID-19 epidemic. |
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Uckun, FM, Carlson, et al |
Frontiers in Pharmacology |
Therapeutics| Thérapeutique Animal model | Modèle animal RCT |
RJX is being developed as an anti-inflammatory and anti-oxidant treatment platform for patients with sepsis, including
COVID-19 patients with viral sepsis and ARDS. A phase 1, double-blind, placebo-controlled, randomized, two-part, ascending dose-escalation study was performed in participating 76 healthy volunteer human subjects in compliance with the ICH (E6) good clinical
practice guidelines to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of RJX (Protocol No. RPI003; ClinicalTrials.gov Identifier: NCT03680105). RJX showed a very favorable safety profile and tolerability in human subjects. It shows
potential to favorably affect the clinical course of high-risk COVID-19 by preventing ARDS and its complications. |
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COVID-19 is Having A Destructive Impact On Healthcare Workers' Mental Wellbeing |
Vanhaecht, K, Seys, et al |
Int J Qual Health Care |
Mental Health |
|
A cross-sectional survey study, conducted between April 2nd and May 4th 2020 (2 waves), led to a convenience sample
of 4509 healthcare workers in Flanders (Belgium), including paramedics (40.6%), nurses (33.4%), doctors (13.4%) and management staff (12.2%) and asked for positive and negative mental health symptoms before and during COVID-19. The association between COVID-19
and mental health was generally strongest for the age group 30-49 years, females, nurses, and residential care centers. A considerable proportion, respectively 18% and 27%, reported the need for professional guidance from psychologists and more support from
their leadership. |
|
Varsavsky, Thomas, Graham, et al |
The Lancet Public Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this prospective, observational study, we did modelling using longitudinal, self-reported data from users of the
COVID Symptom Study app in England between March 24, and Sept 29, 2020. We calculated incidence of COVID-19 using the invited swab (RT-PCR) tests reported in the app, and we estimated prevalence using a symptom-based method (using logistic regression) and
a method based on both symptoms and swab test results. |
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Velasquez, Nicolas, Velasquez, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
We show that malicious COVID-19 content, including racism, disinformation, and misinformation, exploits the multiverse
of online hate to spread quickly beyond the control of any individual social media platform. We provide a first mapping of the online hate network across six major social media platforms. We demonstrate how malicious content can travel across this network
in ways that subvert platform moderation efforts. Machine learning topic analysis shows quantitatively how online hate communities are sharpening COVID-19 as a weapon, with topics evolving rapidly and content becoming increasingly coherent. Based on mathematical
modeling, we provide predictions of how changes to content moderation policies can slow the spread of malicious content. |
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Home management of children with COVID-19 in the Emilia-Romagna region, Italy |
Vergine, G, Fantini, et al |
Frontiers in Pediatrics |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In most children, coronavirus disease 2019 (COVID-19) is a mild or moderate disease or asymptomatic. To evaluate the
role of community health houses (CHHs) in the management of children with COVID-19, 1,009 children with suspected SARS-CoV-2 infection were studied in Emilia-Romagna Region, Italy. Among them, 194 (19.2%) resulted positive for SARS-CoV-2. The majority (583,
58%) were tested at home by CHHs, while 426 (42%) were brought to the hospital for testing. Our research shows for the first time the importance of CHHs in the management of COVID-19 in children; because of the high frequency of mild to moderate cases, management
by CHHs can reduce the care load in hospitals. |
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Vicentini, C, Bazzolo, et al |
Am J Trop Med Hyg |
Epidemiology| Épidémiologie |
We analyzed public data from the first 50 days of the epidemic in Italy (from February 24 to April 13, 2020) to evaluate
whether evolving testing strategies and capacity could account for trends in the CFR. The CFR increased during the study period, and a significant positive correlation was found between the CFR and the percentage of positive tests among performed real-time
PCR tests (positive tests % [POS%]) until March 25, suggesting the surveillance system did not detect a growing number of cases in the initial phase of the epidemic. In the final phase, a decrease in both expCFR and POS% was identified, suggesting an improvement
in surveillance. |
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Putting the network to work: Learning networks in rapid response situations |
Vinson, AH |
Learning Health Systems |
Healthcare Response | Réponse des soins de santé |
A qualitative case study was constructed within a larger ethnographic field study. Document collection and fieldnotes
and recordings from nonparticipant observation of network activities were compiled and chronologically ordered to chart the network's response to changes in epilepsy care resulting from COVID‐19 and the rapid transition to telemedicine. The network's response
to COVID‐19 was characterized by a predisposition to action, the role of sharing as both a group practice and shared value, and the identification of improvement science as the primary contribution of the group within the larger epilepsy community's response
to COVID‐19. |
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Down Syndrome patients with COVID-19 pneumonia: a high-risk category for unfavourable outcome |
Vita, S, Di Bari, et al |
Int J Infect Dis |
Clinical data| Données cliniques |
We report two cases of COronaVIrus Disease-19 in patients with Down Syndrome and describe the identification, diagnosis,
clinical course, and management of the infection. Down Syndrome, which is caused by trisomy 21, is characterized by immune dysregulation, anatomical differences in the upper respiratory tract, and higher rate of comorbidities. All these risk factors can contribute
to more severe clinical presentations of COVID-19. |
|
Wadhwa, A, Fisher, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques Public health interventions*|
Interventions de sant&eacute; publique |
During May 1–19, 2020, two testing strategies were implemented in 12 tiers or housing units of the Cook County Jail
in Chicago, Illinois. Detained persons were approached to participate in serial testing (n=137) tests at 3 time points over 14 days (day 1, day 3–5, and day 13–14). The second group was offered a single test and interview at the end of a 14-day quarantine
period (day 14 group) (n=87). A total of 224 detained persons were approached for participation and of these 194 (87%) participated in at least one interview, and 172 (77%) had at least one test. Of the 172 tested, 19 were positive for SARS-CoV-2. In the serial
testing group, 17 (89%) new cases were detected, sixteen (84%) on day 1, one (5%) on days 3–5, and none on days 13–14; and, in day 14 group, two (11%) cases were identified. More than half (12/19; 63%) of the newly identified cases were pre-symptomatic or
asymptomatic. |
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Rapid lateral flow immunoassay for the fluorescence detection of SARS-CoV-2 RNA |
Wang, D, He, et al |
Nat Biomed Eng |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We report an amplification-free nucleic acid immunoassay, implemented on a lateral flow strip, for the fluorescence
detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in less than one hour. In a multi-hospital randomized double-blind trial involving 734 samples (593 throat swabs and 141 sputum) provided by 670 individuals, the assay achieved
sensitivities of 100% and specificities of 99% for both types of sample (ground truth was determined using quantitative PCR with reverse transcription). The inexpensive amplification-free detection of SARS-CoV-2 RNA should facilitate the rapid diagnosis of
COVID-19 at the point of care. |
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Wang, S, Feng, et al |
Frontiers in Psychiatry |
Mental Health |
|
A self-compiled COVID-19 Social Mentality Questionnaire was used to conduct an online survey. A total of 16,616 participants
responded, with 13,511 valid questionnaires. Results showed that 10.7% of participants rated their mental health as “worse than usual” during the pandemic, and there were gender, age, and educational differences. Social support was positively correlated with
pandemic-related knowledge and self-efficacy, and could indirectly predict mental health. Pandemic-related knowledge was positively correlated with self-efficacy and mental health. Social support can increase pandemic-related knowledge, thus improving self-efficacy
and maintaining/promoting mental health. High risk levels can undermine the role of self-efficacy in promoting mental health. |
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Wang, Stephen, Pine, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques Immunology | Immunologie |
We report on our experience in clinical laboratory assessment of cytokine levels in patients hospitalized with COVID-19.
We demonstrate alarming discrepancies in levels of cytokines reported by different vendors. Moreover, they prompt caution when comparing cytokine levels in patients with COVID-19 and other disease entities due to potential variations in assay platforms and
temporality. Our results underscore an urgent need for standardizing such tests that guide prognostication and therapeutic intervention. |
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Wang, Y, Ru, et al |
Evidence-based Complementary and Alternative Medicine |
Therapeutics| Thérapeutique Immunology | Immunologie |
Network pharmacological approaches along with candidate compound screening, target prediction, target tissue location,
protein-protein interaction network, gene ontology (GO), KEGG enrichment analyses, and gene microarray analyses were applied in Wuhan.. A total of 627 targets of the 116 active ingredients of SZS were identified. A total of 597 targets were enriched in the
GO biological cellular process, while 153 signaling pathways were enriched according to the KEGG analysis. A total of 450 SARS-related targets were integrated and intersected with the targets of SZS to identify 40 common targets that were significantly enriched
in five immune function aspects of the immune system process during GO analysis. |
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[Experience Caring for a Severe COVID-19 Patient With ARDS in the Intensive Care Unit] |
Wang, YP, Chuang, et al |
Hu Li Za Zhi |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This case report provides a reference demonstrating a patient-centered caring model for treating COVID-19 patients
in the ICU. The care period was from April 5th to May 12th, 2020. After administering individualized treatments, including monitoring vital signs and installing an external life support system, the lung consolidation and lung collapse problems of the patient
improved, allowing the ventilator to be removed. To address the patient's psychological problems, we used a humanoid diagram and whiteboard drawing as communication tools to explain to the patient the reasons for and functions of the different tubes on his
body to reduce his anxiety and maintain the safe use of these tubes. |
|
Wang, YX, Gou, et al |
Sichuan da xue xue bao.Yi xue ban = Journal of Sichuan University.Medical science edition |
Clinical data| Données cliniques |
A total of 90 patients with severe/critically severe COVID-19 were included, who were diagnosed and treated in COVID-19
designated hospital of Sichuan province from 11 January 2020 to 20 March 2020. Clinical features, test results, treatment options and clinical outcomes were analyzed retrospectively. 53 patients had various degrees of neurologic manifestations, including 33
cases of fatigue, 21 muscle soreness, 12 dizziness, 8 headaches, 3 mental disorders, and 1 consciousness disorders and 1 case of neck pain. Compared with the patients without neurologic manifestations, those with neurologic manifestations took a longer time
from admission to diagnosis of COVID-19 (P<0.05), and received more antifungal treatment (P<0.05). |
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Wang, Zhizhong, Koenig, et al |
Research Square prepub |
Mental Health |
|
A total of 583 nurses and 2,423 physicians were recruited from across mainland China. An online survey was conducted
from March 27 to April 26, 2020 (during the middle of the COVID-19 pandemic) using the Chinese version of the MISS-HP. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed to determine scale structure. EFA suggested three
factors, and the CFA indicated good fit to the data. Convergent validity was demonstrated with the 4-item Expressions of Moral Injury Scale (r=0.45 for physicians, r=0.43 for nurses). Discriminant validity was demonstrated by correlations with burnout and
well-being (r=0.34–0.47), and concurrent validity was suggested by correlations with depression and anxiety symptoms (r=0.37–0.45). Known groups validity was indicated by a higher score in those exposed to workplace violence (B=4.16, 95%CI: 3.21-5.10, p<0.001). |
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Detection of SARS-CoV-2 in saliva: implications for specimen transport and storage |
Williams, E, Isles, et al |
J Med Microbiol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We undertook an in vitro study to assess whether SARS-CoV-2 could be detected in contrived saliva samples. SARS-CoV-2
was detected in all SARS-CoV-2 spiked samples at time point 0, day 1, 3 and 7 at both storage temperatures using the N gene RT-PCR assay and time point 0, day 1 and day 7 using the Xpert Xpress SARS-CoV-2 (Cepheid, Sunnyvale, USA) RT-PCR assay. The ability
to detect SARS-CoV-2 in saliva over a 1 week period is an important finding that presents further opportunities for saliva testing as a diagnostic specimen for the diagnosis of SARS-CoV-2. |
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Lung lesions detection from CT images based on the modified Faster R-CNN |
Xu, L, Mao, et al |
|
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This paper is based on Faster R-CNN, an end-to-end target detection model, to realize the detection of lesions in CT
images of the novel coronavirus, which contributes to track the later condition of the confirmed patients and conduct timely treatment. The results show that, in the enhanced dataset, the Faster R-CNN model based on VGG-16 achieved a better performance, the
Recall and Precision of which on the overall test set reached 68.12% and 65.58% respectively, and the missed detection rate(MR) was 31.88%. |
|
The Twitter Social Mobility Index: Measuring Social Distancing Practices With Geolocated Tweets |
Xu, P, Dredze, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
The aim of this study is to present the Twitter Social Mobility Index, a measure of social distancing and travel derived
from Twitter data. We collected 469,669,925 tweets geotagged in the United States from January 1, 2019, to April 27, 2020. We analyzed the aggregated mobility variance of a total of 3,768,959 Twitter users at the city and state level from the start of the
COVID-19 pandemic. We observed larger travel reductions in states that were early adopters of social distancing policies and smaller changes in states without such policies. |
|
Yang, Y, Liu, et al |
Int J Environ Res Public Health |
Mental Health |
|
Using a cross-sectional dataset collected through an online survey in February 2020, in China, we examined (1) the
relationships between social media activities and people’s mental health status and (2) the moderation effect of emotional-regulation strategies. The sample included people aged ≥18 years from 32 provinces and regions in China (N = 3159). Our findings expanded
the theory of how social media activities can be associated with a human being’s mental health and how it can interact with emotion-regulation strategies during the COVID-19 pandemic. |
|
|
Yang, Y, Shi, et al |
Blood Purif |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to assess the association between prolonged intermittent renal replacement therapy (PIRRT) and mortality in
patients with COVID-19 undergoing invasive mechanical ventilation in this retrospective cohort study included all COVID-19 patients receiving invasive mechanical ventilation between February 12 and March 2, 2020. The association between PIRRT and a reduced
risk of mortality remained significant in 3 different models, with adjusted hazard ratios varying from 0.332 to 0.398. Increased IL-2 receptor, TNF-α, procalcitonin, prothrombin time, and NT-proBNP levels were significantly associated with an increased risk
of mortality in patients with PIRRT. |
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Perioperative considerations for COVID-19 patients: lessons learned from the pandemic -a case series |
Yek, JLJ, Kiew, et al |
Korean J Anesthesiol |
Clinical data| Données cliniques |
Here, we present the management of a suspected COVID-19 patient. Our objective was to facilitate surgical management
of patients with known or suspected COVID-19 while minimizing the risk of nosocomial transmission to healthcare workers and other patients. |
|
Yildirim, Serap Aktas, Sarikaya, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
We investigate the effect of surgery and intervention on COVID-19 disease progression, intensive care (ICU) need, mortality,
and virus transmission to patients and healthcare workers in this retrospective study conducted between 20 March -20 May 2020 in six hospitals in Istanbul. 1,273 surgical, 476 nonoperating room intervention patients, and 1,884 COVID-19 inpatients were examined.
Emergency surgeries and interventions during the pandemic period did not increase mortality and can be performed safely with very low transmission rates by complying with the effective use of personal protective equipment. |
|
|
Yuhua, F, Jinghao, et al |
Pharmaceutical Care and Research |
Mental Health |
|
This study, using a questionnaire survey of 4148 students , investigated the mental status of university or college
students kept at home due to serious Corona Virus Disease-2019（COVID-19）
epidemic and provide them with mental education and counseling, and also to screen those with mental anxiety, so as to identify the influential factors of anxiety. During the COVID-19 epidemic，
university or college students displayed different levels of anxiety.Both government and university administrations should be highly aware and pay close attention to the mental problems of the students，
and provide mental counseling to those students with mild mental problems，
so as to help them beat back the epidemic situation and tide over mental crisis. |
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Zeltyn-Abramov, E, Belavina, et al |
Nephrology and Dialysis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The purpose of the study was to analyze the structural and functional characteristics of the heart and risk factors
(RF) of an unfavorable outcome of COVID-19 in patients (n=85) on programmed hemodialysis (PGD). Predictors of an unfavorable course of COVID-19 in patients on PGD are: the need for mechanical ventilation, FAC during hospitalization, CCI ≥6 points, LVEF ≤45%,
male sex. |
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Zeltyn-Abramov, E, Belavina, et al |
Nephrology and Dialysis |
Clinical data| Données cliniques |
Three case reports of cardiac injury in patients on maintenance hemodialysis (MHD) with COVID-19 are presented. Of
note, the course of COVID-19 in patients on MHD is more complicated in comparison with the general population. The crucial role of persistent chronic inflammation, coagulopathy, pulmonary hypertension, permanent hemodynamic stress and fluctuation of volemic
status should also be taken into consideration. MHD by itself is a powerful risk factor which overburdens the course of COVID-19. |
|
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A predictive model for the severity of COVID-19 in elderly patients |
Zeng, F, Deng, et al |
Aging |
Epidemiology| Épidémiologie Clinical data| Données cliniques Diagnostics / Pathogen
detection| Diagnostics / Détection d'agents pathogènes |
In this study, elderly patients who maintained a non-severe condition and patients who progressed to severe or critical
COVID-19 during hospitalization were assigned to the non-severe and severe groups, respectively. Based on the admission data of these two groups in the training cohort, albumin (odds ratio [OR] = 0.871, 95% confidence interval [CI]: 0.809 - 0.937, P < 0.001),
d-dimer (OR = 1.289, 95% CI: 1.042 - 1.594, P = 0.019) and onset to hospitalization time (OR = 0.935, 95% CI: 0.895 - 0.977, P = 0.003) were identified as significant predictors for the severity of COVID-19 in elderly patients. By combining these predictors,
an effective risk nomogram was established for accurate individualized assessment of the severity of COVID-19 in elderly patients. The concordance index of the nomogram was 0.800 in the training cohort and 0.774 in the validation cohort. |
|
Zhang, L, Zheng, et al |
Frontiers in Immunology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we constructed a combinatorial fragment of antigen-binding (Fab)antibody phage library based on peripheral blood-derived
from five coronavirus disease 2019 (COVID-19) infected donors. From the library, 159 Fab antibodies were obtained and identified by panning with NP. Among them, 16 antibodies were evaluated for their binding properties and epitopes recognition. Among these
16 antibodies, two well-paired antibodies were finally screened out for SARS-CoV-2 diagnosis by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) method. Our works may provide a potential resource for the clinical diagnosis of SARS-CoV-2 infection. |
|
|
Zhang, Y, Cheng, et al |
JMIR Public Health Surveill |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique |
This study aimed to provide a quantitative analysis of the predicted impact that regular testing of health care workers
for COVID-19 may have on the prevention of the disease among emergency department patients and staff. Using publicly available data on COVID-19 cases and emergency department visits, as well as internal hospital staffing information, we developed a mathematical
model to predict the impact of periodic COVID-19 testing of asymptomatic staff members of the emergency department in COVID-19–affected regions. Periodic COVID-19 testing for emergency department staff in regions that are heavily affected by COVID-19 or are
facing resource constraints may significantly reduce COVID-19 transmission among health care workers and previously uninfected patients. |
|
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Reduction in healthcare services during the COVID-19 pandemic in China |
Zhang, YN, Chen, et al |
BMJ Global Health |
Public Health response| Interventions de santé publique |
Using a big data approach, we collected data from 300 million bank card transactions to measure individual healthcare
expenditure and utilisation in mainland China before, during and after the Spring Festival in 2020 and 2019. The COVID-19 pandemic had a significantly negative effect on healthcare utilisation in China, evident by a dramatic decline in healthcare expenditure.
While the utilisation level has gradually increased post-outbreak, it has yet to return to normal levels. |
|
Automatic COVID-19 CT segmentation using U-Net integrated spatial and channel attention mechanism |
Zhou, T, Canu, et al |
International Journal of Imaging Systems and Technology |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
It is of great importance to rapidly and accurately segment COVID‐19 from Computed Tomography (CT) to help diagnostic
and patient monitoring. In this paper, we propose a U‐Net based segmentation network using attention mechanism. The experiment results, evaluated on a COVID‐19 CT segmentation dataset where 473 CT slices are available, demonstrate the proposed method can
achieve an accurate and rapid segmentation result on COVID‐19. The method takes only 0.29 second to segment a single CT slice. The obtained Dice Score and Hausdorff Distance are 83.1% and 18.8, respectively. |
|
Trend Analysis of COVID-19 Based on Network Topology Description |
Zhu, J, Jiang, et al |
Frontiers in Physics |
Modelling/ prediction| Modélisation/prédiction |
In this study, the trend of the epidemic situation of COVID-19 is analyzed based on the analysis method for network
topology. Through the value of the trend function, we can analyze the trend of the epidemic situation in real time. It is found that if the value of the trend function tends to decrease, it means that the epidemic will have to be effectively controlled. Finally,
we put forward some suggestions for early control of the epidemic. |
|
|
J Hypertens |
Healthcare Response | Réponse des soins de santé |
We explored the impact on hypertension care in the Excellence Center (EC) network of the European Society of Hypertension.
Patient care in hypertension ECs was compromised during the Covid-19-related shutdown. |
|
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Almeda, Nerea, Garcia-Alonso, et al |
Research Square prepub |
Review Literature| Revue de littérature |
SR: search strategy was piloted in Google on April 15th, 2020.In this framework, the relevance of adapting e-mental
health procedures to community mental health care model principles was highlighted, although some problems related to the digital gap must be considered. |
|
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Awadasseid, A, Wu, et al |
International Journal of Biological Sciences |
Review Literature| Revue de littérature |
|
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Awadasseid, A, Wu, et al |
International Journal of Biological Sciences |
Review Literature| Revue de littérature |
|
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Radiological mimickers of covid-19 pneumonia: A pictorial review |
Bakhshayeshkaram, M, Haseli, et al |
Tanaffos |
Review Literature| Revue de littérature |
|
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Borcherding, N, Jethava, et al |
Drug design, development and therapy |
Review Literature| Revue de littérature |
|
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Chan, DX, Lin, et al |
Annals of the Academy of Medicine, Singapore |
Review Literature| Revue de littérature |
|
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Chauhan, N, Soni, et al |
J Med Virol |
Review Literature| Revue de littérature |
SR: literature search for last five years was conducted in databases including PubMed, Google Scholar and online
web resources. In order to develop effective vaccine platforms against SARS-CoV-2, the genetic resemblance with other coronaviruses are being evaluated which may further promote fast-track trials on previously developed SARS-CoV vaccines |
|
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Chen, Po-Hsu Allen, Leibrand, et al |
arXiv |
Review Literature| Revue de littérature |
|
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[Reviewing and Reflecting on Nursing During the COVID-19 Pandemic] |
Chen, SL |
Hu Li Za Zhi |
Review Literature| Revue de littérature |
|
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Chishtie, JA, Marchand, et al |
J Med Internet Res |
Review Literature| Revue de littérature |
ScR: the review focuses on peer-reviewed journal articles and full conference papers from 2005 to March 2019. With
the increasing availability and generation of big health care data, VA is a fast-growing method applied to complex health care data. What makes VA innovative is its capability to process multiple, varied data sources to demonstrate trends and patterns for
exploratory analysis, leading to knowledge generation and decision support. This is the first review to bridge a critical gap in the literature on VA methods applied to the areas of population health and HSR, which further indicates possible avenues for the
adoption of these methods in the future. |
|
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Therapeutic Measures for the Novel Coronavirus: A Review of Current Status and Future
Perspective |
Darvish, M, Shahverdi, et al |
Curr Mol Med |
Review Literature| Revue de littérature |
|
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Dërmaku-Sopjani, M, Sopjani, et al |
Curr Mol Med |
Review Literature| Revue de littérature |
|
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Vulnerable learners in the age of COVID-19: A scoping review |
Drane, CF, Vernon, et al |
Australian Educational Researcher |
Review Literature| Revue de littérature |
ScR
|
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El Keshky, MES, Basyouni, et al |
Frontiers in Psychology |
Review Literature| Revue de littérature |
SR: computerized literature search was performed, and journal articles from authentic sources were extracted, including
MEDLINE (PubMed), Google Scholar, Science Direct, ProQuest, and Emerald Insight for articles published 2010 to 2020.
|
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Ferrari, F, Visconti, et al |
Minerva anestesiologica |
Review Literature| Revue de littérature |
|
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Fung, AT |
International Journal of Ophthalmology |
Review Literature| Revue de littérature |
|
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Pandemics and infodemics: Research on the effects of misinformation on memory |
Greenspan, RL, Loftus, et al |
Human Behavior and Emerging Technologies |
Review Literature| Revue de littérature |
|
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Partisanship in Initial State Responses to the COVID-19 Pandemic |
Gusmano, MK, Miller, et al |
World Medical and Health Policy |
Review Literature| Revue de littérature |
|
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Henzinger, H, Barth, et al |
Viruses |
Review Literature| Revue de littérature |
|
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Viral cultures for COVID-19 infectious potential assessment - a systematic review |
Jefferson, T, Spencer, et al |
Clin Infect Dis |
Review Literature| Revue de littérature |
SR: We searched LitCovid, medRxiv, Google Scholar and the WHO Covid-19 database for Covid-19 to 10 September 2020.
Complete live viruses are necessary for transmission, not the fragments identified by PCR. Prospective routine testing of reference and culture specimens and their relationship to symptoms, signs and patient co-factors should be used to define the reliability
of PCR for assessing infectious potential. Those with high cycle threshold are unlikely to have infectious potential. |
|
Kee, T, Hl, et al |
Annals of the Academy of Medicine, Singapore |
Review Literature| Revue de littérature |
|
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Koshy, AN, Murphy, et al |
Internal Medicine Journal |
Review Literature| Revue de littérature |
SR-MA: search of MEDLINE, PubMed and EMBASE was conducted. Use of ACEI or ARB was not associated with a heightened
susceptibility for a positive diagnosis of COVID-19. Furthermore, they were not associated with increased illness severity or mortality due to COVID-19. |
|
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Kunz, Y, Horninger, et al |
BJU Int |
Review Literature| Revue de littérature |
|
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Laudanski, K, Shea, et al |
Healthcare (Basel) |
Review Literature| Revue de littérature |
|
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López-Bueno, R, López-Sánchez, et al |
Prev Med |
Review Literature| Revue de littérature |
|
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COVID-19 infodemic on Chinese social media: A 4P framework, selective review and research directions |
Luo, J, Xue, et al |
Measurement and Control (United Kingdom) |
Review Literature| Revue de littérature |
|
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Pivoting dental practice management during the covid-19 pandemic—a systematic review |
Mahdi, SS, Ahmed, et al |
Medicina (Lithuania) |
Review Literature| Revue de littérature |
SR: sequential systematic literature search was conducted from December 2019 to 30 April 2020 through PubMed, CINAHL,
Scopus, Google Scholar, Embase, and Web of Science databases. Although the COVID-19 pandemic has had a substantial impact on the dental profession worldwide, our review highlights many practice management approaches to adopt the new norm. More research highlighting
evidence-based safety practices and multisectoral collaboration is required to help dental professionals make informed decisions and make the profession safe, both for the patient and dental professionals.
|
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Marcenes, W |
Community Dent Health |
Review Literature| Revue de littérature |
|
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A novel coronavirus disease (COVID-19): A review of host cell signaling pathways |
Mohammadpour, H, Ziai, et al |
Tanaffos |
Review Literature| Revue de littérature |
|
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Nembhard, MD, Burton, et al |
Toxicology and industrial health |
Review Literature| Revue de littérature |
|
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Anesthesia guidelines for COVID-19 patients: a narrative review and appraisal |
Ong, S, Lim, et al |
Korean J Anesthesiol |
Review Literature| Revue de littérature |
|
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O'Rourke, RW, Lumeng, et al |
Obesity (Silver Spring) |
Review Literature| Revue de littérature |
|
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Pai, SM, Othman, et al |
J Clin Pharmacol |
Review Literature| Revue de littérature |
|
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Puyat, JH, Ahmad, et al |
PLoS One |
Review Literature| Revue de littérature |
Rapid Review: MEDLINE, EMBASE, CINAHL, PyscINFO, Global Health, epistemonikos.org, covid19reviews.org, and eppi.ioe.ac.uk/covid19_map_v13.html.
Eligible studies include randomized controlled trials and non-randomized studies published between 1/1/2000 and 28/05/2020. There is some evidence that certain home-based activities can promote mental wellness during the COVID-19 pandemic.
|
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Ranjith, PV, Varma, et al |
European Journal of Molecular and Clinical Medicine |
Review Literature| Revue de littérature |
|
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Rawson, TM, Moore, et al |
Clin Infect Dis |
Review Literature| Revue de littérature |
Rapid Review: MEDLINE, EMBASE, and Web of Science were searched. Despite frequent prescription of broad-spectrum empirical
antimicrobials in patients with coronavirus-associated respiratory infections, there is a paucity of data to support the association with respiratory bacterial/fungal coinfection.
|
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Sa'diah, M, Mujahidin, et al |
Asian ESP Journal |
Review Literature| Revue de littérature |
|
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How SARS-CoV-2 (COVID-19) spreads within infected hosts - what we know so far |
Sanyal, S |
Emerg Top Life Sci |
Review Literature| Revue de littérature |
|
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Recent progress in the repurposing of drugs/molecules for the management of COVID-19 |
Sharma, D, Kunamneni, et al |
Expert Rev Anti Infect Ther |
Review Literature| Revue de littérature |
|
|
Simons, D, Shahab, et al |
Addiction |
Review Literature| Revue de littérature |
SR-MA: Published articles and pre-prints were identified via MEDLINE and medRxiv. Compared with never smokers, current
smokers appear to be at reduced risk of SARS-CoV-2 infection, while former smokers appear to be at increased risk of hospitalization, increased disease severity and mortality from COVID-19. However, it is uncertain whether these associations are causal. |
|
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Świątkowska, B, Walusiak-Skorupa, et al |
Med Pr |
Review Literature| Revue de littérature |
|
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Tau, N, Yahav, et al |
Hum Vaccin Immunother |
Review Literature| Revue de littérature |
|
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Valenzano, A, Scarinci, et al |
Medicina (Lithuania) |
Review Literature| Revue de littérature |
|
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Development of SARS-CoV-2 vaccines: challenges, risks, and the way forward |
Vashishtha, VM, Kumar, et al |
Hum Vaccin Immunother |
Review Literature| Revue de littérature |
|
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ORGANIZATION OF MEDICAL CARE FOR ELDERLY PATIENTS UNDER THE CONDITIONS OF THE COVID-19
PANDEMIC |
Vasilyev, AO, Sazonova, et al |
Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny |
Review Literature| Revue de littérature |
|
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Veldtman, GR, Pirisi, et al |
Open Heart |
Review Literature| Revue de littérature |
|
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Von Philipsborn, P, Biallas, et al |
BMJ Open |
Review Literature| Revue de littérature |
SR: searched MEDLINE, EMBASE and the WHO COVID-19 database up to 31 March 2020. It is unclear whether the use of NSAIDs
increases the risk of severe adverse outcomes in patients with viral respiratory infections. |
|
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Therapeutic targeting of interleukin-6 for the treatment of COVID-19 |
Wang, Y, Liu, et al |
Eur Cytokine Netw |
Review Literature| Revue de littérature |
|
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Public Health Emergencies of International Concern: A Historic Overview |
Wilder-Smith, A, Osman, et al |
J Travel Med |
Review Literature| Revue de littérature |
|
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Surgical Re-entry Strategy Following COVID-19 Pandemic: A Tiered and Balanced Approach |
Wohler, AD, Kneisl, et al |
Med Care |
Review Literature| Revue de littérature |
|
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Yifan, C, Jun, et al |
Frontiers in Endocrinology |
Review Literature| Revue de littérature |
SR-MA: deep literature search was performed in the databases through August 21, 2020. We comprehensively assessed
the clinical characteristics of patients of different ages with COVID-19 and found that elder patients had a high risk of chronic cardiovascular and metabolism comorbidities. The characteristic clinical manifestations and laboratory examinations of elderly
patients support their excessive inflammation and weak immune defenses against 2019-nCoV.
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Yu, J, Goldminz, et al |
Dermatitis |
Review Literature| Revue de littérature |
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Covid-19: Screening without scrutiny, spending taxpayers' billions |
Abbasi, K |
The BMJ |
Commentary/Editorial| Commentaire/Éditorial |
|
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Analgesia and Sedation Strategies in Mechanically Ventilated Adults with COVID-19 |
Adams, CD, Altshuler, et al |
Pharmacotherapy |
Commentary/Editorial| Commentaire/Éditorial |
|
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Adamus, R |
International and Comparative Law Review |
Commentary/Editorial| Commentaire/Éditorial |
|
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Can Cytokine Serum Levels Be Useful With Kidney Transplantation and COVID-19? |
Adani, GL, Pravisani, et al |
Prog Transplant |
Commentary/Editorial| Commentaire/Éditorial |
|
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Preliminary modeling of Coronavirus (COVID-19) spread in construction industry |
Afkhamiaghda, M, Elwakil, et al |
Journal of Emergency Management |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ahmad, A, Kirmani, et al |
International Journal of Electronic Government Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Polio Amidst COVID-19 in Pakistan: What are the Efforts Being Made and Challenges at Hand? |
Ahmad, S, Babar, et al |
Am J Trop Med Hyg |
Commentary/Editorial| Commentaire/Éditorial |
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Aksenova, EI, Petrova, et al |
Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny |
Commentary/Editorial| Commentaire/Éditorial |
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Al Hajri, HH, Al Mughairi, et al |
European Journal of Molecular and Clinical Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Impact of COVID 19 on
FM services and strategies to overcome this situation in GCC countries |
Al Rashdi, B, Ramaswamy, et al |
European Journal of Molecular and Clinical Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Alagha, MA, Jaulin, et al |
J Patient Saf |
Commentary/Editorial| Commentaire/Éditorial |
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Aldekhyl, SS, Arabi, et al |
Annals of Thoracic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Willingness of parents to vaccinate their children against influenza and COVID-19 |
AlHajri, B, Alenezi, et al |
J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Alipoor, SD, Jamaati, et al |
Tanaffos |
Commentary/Editorial| Commentaire/Éditorial |
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Alkasir, A, Lippmann, et al |
Prim Care Companion CNS Disord |
Commentary/Editorial| Commentaire/Éditorial |
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Alvarez-Placencia, I, Sánchez-Partida, et al |
Advances in Science, Technology and Engineering Systems |
Commentary/Editorial| Commentaire/Éditorial |
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Álvarez-Rosales, H, Fernández-Rivera, et al |
Arch Cardiol Mex |
Commentary/Editorial| Commentaire/Éditorial |
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Mainstream reintegration of COVID-19 survivors and its implications for mental health care
in Africa |
Ameyaw, EK, Hagan, et al |
The Pan African medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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Ameyaw, EK, Hagan, et al |
The Pan African medical journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Clergymen in hospitals as patient companions during the covid-19 pandemic |
Aminnejad, R, Shafiee, et al |
Tanaffos |
Commentary/Editorial| Commentaire/Éditorial |
|
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Organisational Change in a (Post-) Pandemic World: Rediscovering Interests and Values |
Amis, JM, Greenwood, et al |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
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Essential workers: A multiplayer game for enacting patterns of social interdependency in a pandemic |
Anupam, A, Stricklin, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Lockdown Boredom in COVID-19 Pandemic: As a Cause of Pediatric Foreign Bodies |
Arora, R, Singh, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19-Associated Acute Disseminated Encephalomyelitis-Like Disease |
Assunção, FB, Fragoso, et al |
AJNR Am J Neuroradiol |
Commentary/Editorial| Commentaire/Éditorial |
|
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A double-edged sword of using opioids and COVID-19: a toxicological view |
Ataei, M, Shirazi, et al |
Subst Abuse Treat Prev Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Ateya, AM, Sabri, et al |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
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Badgujar, KC, Badgujar, et al |
Indian Chemical Engineer |
Commentary/Editorial| Commentaire/Éditorial |
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Balavoine, JF |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of COVID-19 Pandemic on Pediatric Infectious Disease Research |
Bensoussan, E, Ouldali, et al |
J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Design aspects of COVID-19 treatment trials: Improving probability and time of favourable events |
Beyersmann, Jan, Friede, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Bianco, C, Baselli, et al |
Liver International |
Commentary/Editorial| Commentaire/Éditorial |
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Helping translator trainees explore specialised languages during the Covid-19 crisis |
Bordet, G |
ASp |
Commentary/Editorial| Commentaire/Éditorial |
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Borno, HT, Idossa, et al |
JCO Oncol Pract |
Commentary/Editorial| Commentaire/Éditorial |
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Flattening the Curve is Flattening the Complexity of COVID-19 |
Boumans, MarcelJ |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Follow-up after oral cancer treatment transition to a personalised approach |
Brands, M, Verbeek, et al |
J Oral Pathol Med |
Commentary/Editorial| Commentaire/Éditorial |
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Bransky, A, Larsson, et al |
J Appl Lab Med |
Commentary/Editorial| Commentaire/Éditorial |
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Platforms and the pandemic: A case study of fashion rental platforms during COVID-19 |
Brydges, T, Heinze, et al |
Geographical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Buonvino, S, Melino, et al |
Cell Death Discovery |
Commentary/Editorial| Commentaire/Éditorial |
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Rapid Translation of COVID-19 Preprint Data into Critical Care Practice |
Burrell, AJ, Serpa Neto, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Burstein, B, Lefebvre, et al |
Canadian Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Caldas, MP, Ostermeier, et al |
J Appl Psychol |
Commentary/Editorial| Commentaire/Éditorial |
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Generating evidence for therapeutic effects: the need for well-conducted randomized trials |
Califf, RM, Curtis, et al |
J Clin Invest |
Commentary/Editorial| Commentaire/Éditorial |
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Carson, SL, Gonzalez, et al |
Journal of health care for the poor and underserved |
Commentary/Editorial| Commentaire/Éditorial |
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Center, KE, Da Silva, et al |
MMWR Morb Mortal Wkly Rep |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19, ARDS, ACOVCS, MIS-C, KD, PMIS, TSS, MIS-A: Connecting the Alphabet? |
Chambers, Patrick |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Chan, Y, Banglawala, et al |
J Otolaryngol Head Neck Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Reply to: video laryngoscopy during airway management in COVID-19 patients |
Chen, C, Shen, et al |
Eur J Anaesthesiol |
Commentary/Editorial| Commentaire/Éditorial |
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[Reflections on the Nursing Work Environment in Light of the Experience With COVID-19] |
Chen, YF, Yang, et al |
Hu Li Za Zhi |
Commentary/Editorial| Commentaire/Éditorial |
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Christianson, MK, Barton, et al |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Clark, MC, Buswell, et al |
J Addict Med |
Commentary/Editorial| Commentaire/Éditorial |
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Codella, R, Chirico, et al |
J Sports Med Phys Fitness |
Commentary/Editorial| Commentaire/Éditorial |
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Cohen, L |
Med Anthropol Q |
Commentary/Editorial| Commentaire/Éditorial |
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Collini, A, Parker, et al |
Emerg Med J |
Commentary/Editorial| Commentaire/Éditorial |
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Corr, M, Christie, et al |
BMJ Open |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19-Associated Pulmonary Aspergillosis: The Other Side of the Coin |
Costantini, C, van de Veerdonk, et al |
Vaccines (Basel) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Daly, J, Black, et al |
Community Dent Health |
Commentary/Editorial| Commentaire/Éditorial |
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Daniels, K, Conway, et al |
Cytometry Part A |
Commentary/Editorial| Commentaire/Éditorial |
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Dan-Nwafor, C, Ochu, et al |
J Glob Health |
Commentary/Editorial| Commentaire/Éditorial |
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Metformin: an inexpensive and effective treatment in people with diabetes and COVID-19? |
Dardano, Angela, Del Prato, et al |
The Lancet Healthy Longevity |
Commentary/Editorial| Commentaire/Éditorial |
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de Feria, A, Ortega-Legaspi, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Plant-based vaccines and antibodies to combat COVID-19: current status and prospects |
Dhama, K, Natesan, et al |
Hum Vaccin Immunother |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in the elderly people and advances in vaccination approaches |
Dhama, K, Patel, et al |
Hum Vaccin Immunother |
Commentary/Editorial| Commentaire/Éditorial |
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Acetyl-l-Carnitine and New-Onset Psychosis During the COVID-19 Pandemic |
Dhir, S, Khalid, et al |
Prim Care Companion CNS Disord |
Commentary/Editorial| Commentaire/Éditorial |
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Anti-interleukin-6 monoclonal antibody for cytokine storm in COVID-19 |
Douedi, S, Chaudhri, et al |
Annals of Thoracic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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A supposed fifth wave of Latin American regionalism and human needs |
Dubé, S |
Regions and Cohesion |
Commentary/Editorial| Commentaire/Éditorial |
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Duboucher, C |
J Infect |
Commentary/Editorial| Commentaire/Éditorial |
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Race, ethnicity, and racism in the nutrition literature: an update for 2020 |
Duggan, CP, Kurpad, et al |
Am J Clin Nutr |
Commentary/Editorial| Commentaire/Éditorial |
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Ecks, S |
Med Anthropol Q |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 Impact on Bucharest Stock Exchange. The First Six Months |
Elena, VD |
Studies in Business and Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Emmerich, K, Krekhov, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Filby, A, Haviland, et al |
Cytometry Part A |
Commentary/Editorial| Commentaire/Éditorial |
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Frankish, A, Diekhans, et al |
Nucleic Acids Res |
Commentary/Editorial| Commentaire/Éditorial |
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Fuady, A, Houweling, et al |
Am J Trop Med Hyg |
Commentary/Editorial| Commentaire/Éditorial |
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Risk at mass-gathering events and the usefulness of complementary events during COVID-19 pandemic |
Furuse, Y |
J Infect |
Commentary/Editorial| Commentaire/Éditorial |
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Gajdzik, B |
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Commentary/Editorial| Commentaire/Éditorial |
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Gandolfi, MG, Zamparini, et al |
Int J Environ Res Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Ghasemnejad-Berenji, M, Pashapour, et al |
Med Hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Gibbs, JL, Nonnenmann, et al |
Toxicology and industrial health |
Commentary/Editorial| Commentaire/Éditorial |
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Goebel, J, Manion, et al |
International Review of Education |
Commentary/Editorial| Commentaire/Éditorial |
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Gola, M, Caggiano, et al |
Ann Ig |
Commentary/Editorial| Commentaire/Éditorial |
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Willingness of parents to vaccinate and moving towards the post COVID-19 era |
Goldman, RD, Brown, et al |
J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Goud, PT, Bai, et al |
International Journal of Biological Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Percutaneous Endoscopic Gastrostomy tube placement in COVID-19 patients: Multidisciplinary approach |
Goyal, H, Perisetti, et al |
Digestive Endoscopy |
Commentary/Editorial| Commentaire/Éditorial |
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Gravano, DM, Chakraborty, et al |
Cytometry Part A |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 AFFECTING HEREDITARY ANGIOEDEMA PATIENTS WITH AND WITHOUT C1 INHIBITOR DEFICIENCY |
Grumach, AS, Goudouris, et al |
J Allergy Clin Immunol Pract |
Commentary/Editorial| Commentaire/Éditorial |
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Emerging Blood Gas Monitors: How They Can Help with COVID-19 |
Guler, U, Costanzo, et al |
IEEE Solid-State Circuits Magazine |
Commentary/Editorial| Commentaire/Éditorial |
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Identity, Nationalism and the Response of Turkey to COVID-19 Pandemic |
Gülseven, E |
Chinese Political Science Review |
Commentary/Editorial| Commentaire/Éditorial |
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Hashimoto, T, Sawano, et al |
J Glob Health |
Commentary/Editorial| Commentaire/Éditorial |
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Hazarika, K |
European Journal of Molecular and Clinical Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Virus and COVID 19 spread:
In the light of holy quran and hadith |
Helal, MdSA, Bhuiyan, et al |
European Journal of Molecular and Clinical Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Hertelendy, AJ |
Journal of Emergency Management |
Commentary/Editorial| Commentaire/Éditorial |
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Hilbert, T |
Eur J Anaesthesiol |
Commentary/Editorial| Commentaire/Éditorial |
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H'ng, MW, Tan, et al |
Annals of the Academy of Medicine, Singapore |
Commentary/Editorial| Commentaire/Éditorial |
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Horton, Richard |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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A virtual bird’s eye view: Live streaming nest boxes to continue outreach in the era of COVID-19 |
Houtz, JL, Mady, et al |
Ecology and Evolution |
Commentary/Editorial| Commentaire/Éditorial |
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Is there an association between SARS-CoV-2 and Streptococcus pneumoniae? |
Howard, LM |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Huang, Y |
Smart and Sustainable Manufacturing Systems |
Commentary/Editorial| Commentaire/Éditorial |
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Huang, Y, Zhao, et al |
Asian J Psychiatr |
Commentary/Editorial| Commentaire/Éditorial |
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[Care Strategies and Trends in Taiwan During the COVID-19 Pandemic] |
Huang, YC, Chia, et al |
Hu Li Za Zhi |
Commentary/Editorial| Commentaire/Éditorial |
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Ianioglo, A, Rissanen, et al |
Scandinavian Journal of Hospitality and Tourism |
Commentary/Editorial| Commentaire/Éditorial |
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Iskander, N |
Med Anthropol Q |
Commentary/Editorial| Commentaire/Éditorial |
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Biomimetic Nanomaterial Strategies for Virus Targeting: Antiviral Therapies and Vaccines |
Jackman, JA, Yoon, et al |
Advanced Functional Materials |
Commentary/Editorial| Commentaire/Éditorial |
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Safety Considerations for In Situ Simulation in Closed SARS-CoV-2 Units |
Jafri, FN, Shah, et al |
Simul Healthc |
Commentary/Editorial| Commentaire/Éditorial |
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Significance of physiotherapy in "sARS-CoV-2/COVID-19: An Epidemic" |
Jangra, MK, Saxena, et al |
Annals of Thoracic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Jun, S, Simin, et al |
Pharmaceutical Care and Research |
Commentary/Editorial| Commentaire/Éditorial |
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Kaliakparova, GS, Gridneva, et al |
Journal of Security and Sustainability Issues |
Commentary/Editorial| Commentaire/Éditorial |
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Managing Children's Anxiety During COVID-19 Pandemic: Strategies for Providers and Caregivers |
Kang, YQ, Lim, et al |
Frontiers in Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Karim, N, Rybarczyk, et al |
AEM Education and Training |
Commentary/Editorial| Commentaire/Éditorial |
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Hospital preparedness and management of pediatric population during COVID-19 outbreak |
Kazzaz, YM, Alkhalaf, et al |
Annals of Thoracic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Kendi, S, Taylor, et al |
Inj Prev |
Commentary/Editorial| Commentaire/Éditorial |
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Kenny, S |
Community Development Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Khan, A |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Khan, MSI, Nabeka, et al |
J Glob Health |
Commentary/Editorial| Commentaire/Éditorial |
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Brain Death Evaluation in Children With Suspected or Confirmed Coronavirus Disease 2019 |
Kirschen, MP, McGowan, et al |
Pediatr Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Klement, E, Godefroy, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Bereaved families, unions, and charities demand immediate public inquiry to save lives |
Kmietowicz, Z |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Kowsalya, B, Sundara Raj, et al |
European Journal of Molecular and Clinical Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Addressing economic and health challenges of COVID-19 in Bangladesh: Preparation and response |
Kumar, B, Pinky, et al |
Journal of Public Affairs |
Commentary/Editorial| Commentaire/Éditorial |
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Lala, A, Januzzi, et al |
J Am Coll Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
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Online courses in times of pandemic: ESP and applied English classes at Université Paris 8 |
Le Cor, G, Coutherut, et al |
ASp |
Commentary/Editorial| Commentaire/Éditorial |
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Ledesma, F, Del Valle, et al |
Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Leong, KT, Hock, et al |
European Journal of Molecular and Clinical Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Levy, DL |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Lewis, S |
Journal of General and Family Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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China’s economic outlook against the backdrop of the COVID-19 pandemic and US-China tensions |
Lin, JY |
Journal of Chinese Economic and Business Studies |
Commentary/Editorial| Commentaire/Éditorial |
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A Virtual Point-of-care Ultrasound Course During the COVID-19 Pandemic |
Lin, SD |
AEM Education and Training |
Commentary/Editorial| Commentaire/Éditorial |
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[Challenges to the Nursing Practicum During the COVID-19 Pandemic] |
Liu, YM, Chen, et al |
Hu Li Za Zhi |
Commentary/Editorial| Commentaire/Éditorial |
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Liutsko, L, Oughton, et al |
Environ Int |
Commentary/Editorial| Commentaire/Éditorial |
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London, M, Sanchez, et al |
Journal of health care for the poor and underserved |
Commentary/Editorial| Commentaire/Éditorial |
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Transitioning From Immunosuppressants to Dupilumab in Pediatric Atopic Dermatitis |
Ludwig, CM, Hsiao, et al |
Dermatitis |
Commentary/Editorial| Commentaire/Éditorial |
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Obese COVID-19 patients show more severe pneumonia lesions on CT chest imaging |
Luo, XM, Jiaerken, et al |
Diabetes, Obesity and Metabolism |
Commentary/Editorial| Commentaire/Éditorial |
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Luporini, A |
ASp |
Commentary/Editorial| Commentaire/Éditorial |
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Incarceration, covid-19, and emergency release: Reimagining how and when to punish |
Lyons, L |
Kennedy Institute of Ethics journal |
Commentary/Editorial| Commentaire/Éditorial |
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Circadian Clock Genes: Targeting Innate Immunity for Antiviral Strategies Against COVID-19 |
Maiese, K |
Curr Neurovasc Res |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7695082; Stratification of Acute Kidney Injury in COVID-19 |
Mallhi, TH, Khan, et al |
Am J Trop Med Hyg |
Commentary/Editorial| Commentaire/Éditorial |
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Quo vadimus: Humanism, going beyond the boundaries of capitalism and socialism |
Malshe, AP, Bapat, et al |
Smart and Sustainable Manufacturing Systems |
Commentary/Editorial| Commentaire/Éditorial |
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Mamourian, A |
AJNR Am J Neuroradiol |
Commentary/Editorial| Commentaire/Éditorial |
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Manetti, S, Vainieri, et al |
BMJ Open |
Commentary/Editorial| Commentaire/Éditorial |
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Nritld protocol for the management of patients with covid-19 admitted to hospitals |
Marjani, M, Tabarsi, et al |
Tanaffos |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 vaccine trials: We must preserve the ends when communicating the means |
Marshall, HD |
The BMJ |
Commentary/Editorial| Commentaire/Éditorial |
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Martín Giménez, VM, Prado, et al |
Nanomedicine (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
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Martinez, KF, Morrow, et al |
Toxicology and industrial health |
Commentary/Editorial| Commentaire/Éditorial |
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The Effects of COVID-19 Among the Elderly Population: A Case for Closing the Digital Divide |
Martins Van Jaarsveld, G |
Frontiers in Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Masood, S, Chartier, et al |
Canadian Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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The impact of COVID-19 on the management of European protected areas and policy implications |
McGinlay, J, Gkoumas, et al |
Forests |
Commentary/Editorial| Commentaire/Éditorial |
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Mediavilla, R, Muñoz-Sanjosé, et al |
Actas Espanolas de Psiquiatria |
Commentary/Editorial| Commentaire/Éditorial |
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Meurens, F |
Virologie (Montrouge) |
Commentary/Editorial| Commentaire/Éditorial |
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Dengue outbreak during Covid-19 pandemic: A further challenge to the health professionals |
Miah, MA |
Bangladesh Medical Research Council bulletin |
Commentary/Editorial| Commentaire/Éditorial |
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Is it prime time to consider a clinical trial of doxycycline for the management of COVID-19? |
Milionis, H, Kostikas, et al |
Postgrad Med J |
Commentary/Editorial| Commentaire/Éditorial |
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Considerations for educators in supporting student learning in the midst of COVID-19 |
Minkos, ML, Gelbar, et al |
Psychology in the Schools |
Commentary/Editorial| Commentaire/Éditorial |
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Insights From HeartLogic Multisensor Monitoring During the COVID-19 Pandemic in New York City |
Mitter, SS, Alvarez-Garcia, et al |
JACC Heart Fail |
Commentary/Editorial| Commentaire/Éditorial |
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Moneypenny, M, Alinier, et al |
BMJ Simulation and Technology Enhanced Learning |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7454469; It Is Time to Address Airborne Transmission of Coronavirus Disease 2019 (COVID-19) |
Morawska, L, Milton, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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The new norm: Computer Science conferences respond to COVID-19 |
Mubin, O, Alnajjar, et al |
Scientometrics |
Commentary/Editorial| Commentaire/Éditorial |
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Mundial, IQ, Ul Hassan, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Nahas, SC, Meira-JÚnior, et al |
Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Water - Core to beating
Covid-19 and gaining global health security |
Naidoo, D |
Water Wheel |
Commentary/Editorial| Commentaire/Éditorial |
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Nakamoto, M, Carrazana, et al |
Acta Neurologica Scandinavica |
Commentary/Editorial| Commentaire/Éditorial |
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Nelson, RH, Francis, et al |
Kennedy Institute of Ethics journal |
Commentary/Editorial| Commentaire/Éditorial |
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Dose-response effects of hydroxychloroquine on prophylaxis against SARS-CoV-2 / COVID-19 infection |
Neves, FS |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Norwood, FB, Peel, et al |
Applied Economic Perspectives and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Novaes Rocha, V |
Med Hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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The Covid-19 catastrophe, authoritarianism, and refusing to get used to it |
O’Donovan, Ó |
Community Development Journal |
Commentary/Editorial| Commentaire/Éditorial |
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The Impact of the Current Crisis Generated by the COVID-19 Pandemic on Consumer Behavior |
Oana, D |
Studies in Business and Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Acute Ischemic Stroke in COVID-19: Putative Mechanisms, Clinical Characteristics, and Management |
Ojo, AS, Balogun, et al |
Neurology Research International |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in the Indian context and the
quest for alternative paradigms |
Oommen, MA |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Language and health equity during covid-19: Lessons and opportunities |
Ortega, P, Martínez, et al |
Journal of health care for the poor and underserved |
Commentary/Editorial| Commentaire/Éditorial |
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Implementation of Simulation Training During the COVID-19 Pandemic: A New York Hospital Experience |
Pan, D, Rajwani, et al |
Simul Healthc |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and/with dengue infection: A curse in an overburdened healthcare system |
Panda, PK, Sharawat, et al |
Trop Doct |
Commentary/Editorial| Commentaire/Éditorial |
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Park, JJ |
J Glob Health |
Commentary/Editorial| Commentaire/Éditorial |
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Pilloni, G, Bikson, et al |
Frontiers in Human Neuroscience |
Commentary/Editorial| Commentaire/Éditorial |
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Role of corticosteroids in the treatment of COVID-19 infection |
Piraccini, E, Byrne, et al |
Minerva anestesiologica |
Commentary/Editorial| Commentaire/Éditorial |
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Pourani, MR, Abdollahimajd, et al |
Dermatologic Therapy |
Commentary/Editorial| Commentaire/Éditorial |
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Quinn, LM, Davies, et al |
Diabet Med |
Commentary/Editorial| Commentaire/Éditorial |
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Management of COVID-19 in special populations with kidney disease |
Radhakrishnan, Y, Hassanein, et al |
Cleve Clin J Med |
Commentary/Editorial| Commentaire/Éditorial |
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Radojević, B, Lazić, et al |
Geographica Pannonica |
Commentary/Editorial| Commentaire/Éditorial |
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Rahman, SMM, Hossain, et al |
Bangladesh Medical Research Council bulletin |
Commentary/Editorial| Commentaire/Éditorial |
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Rana, W, Mukhtar, et al |
International journal of geriatric psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Ranza, E, Mammi, et al |
European Journal of Neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Reinholz, M, French, et al |
Eur J Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Reischl, U, Mijovic, et al |
Journal of Fiber Bioengineering and Informatics |
Commentary/Editorial| Commentaire/Éditorial |
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Bruton's tyrosine kinase: A promising target for the treatment of covid-19 |
Rezaei, M, Babamahmoodi, et al |
Tanaffos |
Commentary/Editorial| Commentaire/Éditorial |
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Rickert, J |
Clin Orthop Relat Res |
Commentary/Editorial| Commentaire/Éditorial |
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Improving surveillance estimates of COVID-19 incidence in the United States |
Rosenberg, ES, Bradley, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Rosenberg, H, Nath, et al |
Canadian Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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What are we talking about when we talk of steroid in COVID-19? |
Rossato, M |
Minerva anestesiologica |
Commentary/Editorial| Commentaire/Éditorial |
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Correction: Impact of cardiovascular risk profile on COVID-19 outcome. A meta-analysis |
Sabatino, J, De Rosa, et al |
PLoS One |
Commentary/Editorial| Commentaire/Éditorial |
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Editorial – A transformational catastrophe? Online ESP programs in the time of Covid-19 |
Saber, A |
ASp |
Commentary/Editorial| Commentaire/Éditorial |
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Issues related to testing for COVID-19 in a psychiatric emergency setting |
Sadh, K, A, et al |
Asian J Psychiatr |
Commentary/Editorial| Commentaire/Éditorial |
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Sadyah, H, Basuki, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Rapid retooling for emergency response with hybrid manufacturing |
Saleeby, K, Feldhausen, et al |
Smart and Sustainable Manufacturing Systems |
Commentary/Editorial| Commentaire/Éditorial |
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Saliva: an important alternative for screening and monitoring of COVID-19 in children |
Santos, CN, Rezende, et al |
Brazilian oral research |
Commentary/Editorial| Commentaire/Éditorial |
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What is the role of admission HbA1c in managing COVID-19 patients? |
Sathish, T, Cao, et al |
J Diabetes |
Commentary/Editorial| Commentaire/Éditorial |
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Schmidt, Harald, Weintraub, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Schmidt, M, Chommeloux, et al |
Lancet Respir Med |
Commentary/Editorial| Commentaire/Éditorial |
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Managing the Inevitable Surge of Post-COVID-19 Functional Gastrointestinal Disorders |
Schmulson, M, Ghoshal, et al |
Am J Gastroenterol |
Commentary/Editorial| Commentaire/Éditorial |
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The Goldman-Fox Syndrome: Treating and Preventing Green Pseudomonas Nails in the Era of COVID-19 |
Schwartz, RA, Kapila, et al |
Dermatol Ther |
Commentary/Editorial| Commentaire/Éditorial |
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Scudellari, M |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Focussing on 'mental hygiene' along with 'hand hygiene' in the times of COVID-19 |
Sen, MS, Chawla, et al |
Indian J Med Res |
Commentary/Editorial| Commentaire/Éditorial |
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Sharma, B |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
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Sheehan, M |
New Solut |
Commentary/Editorial| Commentaire/Éditorial |
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Gig work and platforms during the COVID-19 pandemic in
India |
Shipra, Behera, M |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Triage management of patients during the outbreak of coronavirus disease 2019 (Covid-19) |
Shirvani, R, Heidarifar, et al |
Tanaffos |
Commentary/Editorial| Commentaire/Éditorial |
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Shok, N, Beliakova, et al |
Kennedy Institute of Ethics journal |
Commentary/Editorial| Commentaire/Éditorial |
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Development of indigenous personal protective equipment coverall by CSIR-NAL |
Shukla, HK, Barshilia, et al |
Indian Chemical Engineer |
Commentary/Editorial| Commentaire/Éditorial |
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Siddiqui, J, Bala, et al |
AJNR Am J Neuroradiol |
Commentary/Editorial| Commentaire/Éditorial |
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Sim, WS, Tan, et al |
Annals of the Academy of Medicine, Singapore |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of the COVID-19 Pandemic on Pediatric Emergency Department Utilization for Asthma |
Simoneau, T, Greco, et al |
Ann Am Thorac Soc |
Commentary/Editorial| Commentaire/Éditorial |
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Singh, S, Herrmann, et al |
J Pain Symptom Manage |
Commentary/Editorial| Commentaire/Éditorial |
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Psychology of wearing face masks to prevent transition of COVID-19 |
Song, LJ, Xu, et al |
General Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Stark, L, Meinhart, et al |
BMJ Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Stokes, AC |
JAMA Netw Open |
Commentary/Editorial| Commentaire/Éditorial |
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Su, JY, Huang, et al |
Hu Li Za Zhi |
Commentary/Editorial| Commentaire/Éditorial |
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Suleman, S, Ratnani, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Swinnen, J, McDermott, et al |
EuroChoices |
Commentary/Editorial| Commentaire/Éditorial |
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Commentary/Editorial| Commentaire/Éditorial |
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Annals of the Academy of Medicine, Singapore |
Commentary/Editorial| Commentaire/Éditorial |
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Tan, WY, Ng, et al |
Annals of the Academy of Medicine, Singapore |
Commentary/Editorial| Commentaire/Éditorial |
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Tediosi, F, Lönnroth, et al |
BMJ Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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[Risk Communication and Community Engagement in the COVID-19 Pandemic in Portugal] |
Teixeira, PM, Vital Brito, et al |
Acta Med Port |
Commentary/Editorial| Commentaire/Éditorial |
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The Lancet Respiratory, Medicine |
Lancet Respir Med |
Commentary/Editorial| Commentaire/Éditorial |
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The, Lancet |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Tiwari, A, Narasimha Reddy, et al |
Smart and Sustainable Manufacturing Systems |
Commentary/Editorial| Commentaire/Éditorial |
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Torres-Atencio, I, Goodridge, et al |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Torricelli, L, Poletti, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Traeger, MW, Patel, et al |
Aids |
Commentary/Editorial| Commentaire/Éditorial |
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Traynor, K |
American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists |
Commentary/Editorial| Commentaire/Éditorial |
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Tuka, V, Godula, et al |
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Unguru, Y |
Clinical Ethics |
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Usher, Ann Danaiya |
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Commentary/Editorial| Commentaire/Éditorial |
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The predictable inequities of covid-19 in the US: Fundamental causes and broken institutions |
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Kennedy Institute of Ethics journal |
Commentary/Editorial| Commentaire/Éditorial |
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Velavan, TP, Meyer, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.*
Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.
Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers.
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Séquelles à long terme:
Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.
Santé mentale:
Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées
à la pandémie.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives