Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19,
2020-12-01
Good afternoon,
There are 678 citations in today’s scan. 371 were considered primary research or review literature.
Highlights today include:
CANADA
·
Wang, X.
proposes a dynamic model that incorporates individuals' behavior change in social interactions at different stages of the epidemics and fit the model to the data in Ontario, Canada, calculating the effective reproduction number Rt within each stage.
Simulations demonstrate that enlarging the testing capacity and motivating infected individuals to test for an early diagnosis may facilitate mitigating the disease spread in a relatively short time. Results also indicate a significantly faster decline of
confirmed positive cases if individuals practice strict physical distancing even if restricted measures are lifted.
·
Hetherington et al studied the factors associated with COVID-19 vaccine intentions among Canadian parents. 60% of parents (n=798) intended to vaccinate their children,
but 9% (n=113) said they did not intend to vaccinate and 31% (n=410) were unsure. Lower education and income were inversely associated with intention to vaccinate. Incomplete vaccination history was associated with intention not to vaccinate but not uncertainty.
·
Murti et al
analyzed public health declared workplace outbreaks between January 21 to June 30, 2020, and their associated cases from January 21 to July 28, to understand industry sectors impacted by workplace outbreaks in the first wave of the pandemic within Ontario,
and the additional burden of illness through household transmission. There were 199 outbreaks with 1245 cases, and 68% of outbreaks and 80% of cases belonged to i) Manufacturing, ii) Agriculture, Forestry, Fishing, Hunting, iii) Transportation and Warehousing.
There were 608 household cases associated with 339 (31%) outbreak cases, increasing the burden of illness by 56%.
EPIDEMIOLOGY
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Romero-Gómez et al
investigated the infectivity of clinical samples obtained from patients with SARS-CoV-2 by comparing the results obtained by RT-PCR with the growth capacity of the virus in vitro. The authors conclude that Ct values cannot be used as a unique tool to
identify those patients who can be infective despite a positive SARS-CoV-2 PCR. Positive cultures were associated with low Ct values but viral growth was obtained in a sample with high Ct values.
·
Pinto et al.
investigate the possible associations between physical activity levels and clinical outcomes among hospitalized patients with severe COVID-19, and find there are no association. Physical activity indexes were not associated with hospital length of stay
mortality, admission to ICU, and mechanical ventilation requirement.
SEROPREVALANCE
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Armann et al.
performed a SARS-CoV-2 seroprevalence study in students and teachers in 13 secondary schools in Saxony, Germany at two timepoints in June and October 2020, respectively. The seroprevalence for SARS-CoV-2 antibodies was 0.6% in May/June and the same in
September/October. Even in schools with reported Covid-19 cases before the lockdown of March 13th no clusters could be identified. These observations do not support school closures as a strategy fighting the pandemic in a low prevalence setting.
·
Ruben et al.
conducted a serologic survey to estimate SARS-CoV-2 seroprevalence and assess risk factors and occupational exposures among a convenience sample of first responders in US. Seropositivity varied by occupation, with 4.8% (3/62) of firefighters; 3.6% (8/220)
of police officers; and no paramedics (0/10) or administration and support staff (0/18) testing positive.
·
Vos et al
use a previously established nationwide serosurveillance study to detect SARS-CoV-2 serum antibodies in the general population of the Netherlands and identify risk factors for seropositivity amidst the first COVID-19 epidemic wave. In the midst of the
first epidemic wave, 2.8% of the Dutch population was estimated to be infected with SARS-CoV-2, that is, 30 times higher than reported. This study identified independent groups with increased odds for seropositivity.
·
Thompson et al
used blood donations in Scotland as a means of estimating population exposure from the first wave of the pandemic. Samples containing anti-SARS-CoV-2 neutralising antibodies were detected in blood donors who gave blood between 16 and 17 March 2020 in
all Scottish health boards. Subsequently, samples containing anti-SARS-CoV-2 neutralising antibodies were detected at every further time point assayed until the end of the study.
·
Cagigi et al
longitudinally assessed systemic and airway immune responses against SARS-CoV-2 in a well-characterized cohort of 147 infected. High systemic and airway antibody responses occurred in patients with moderate to severe disease, and while systemic IgG levels
were maintained after acute disease, airway IgG and IgA declined significantly. In contrast, individuals with mild symptoms showed significantly lower antibody responses but their levels of antigen-specific memory B cells were comparable with those observed
in patients with moderate to severe disease.
THERAPEUTICS
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Ashraf et al.
performed a RCT to investigate the efficacy of honey and nigella sativa (HNS) vs. placebo in patients with moderate or severe COVID-19 treated with standard of care. HNS treatment resulted in a significant reduction in time to symptom alleviation, time
to viral clearance, hospital discharge rate and mortality rate compared to placebo.
VACCINE RESEARCH
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Liu et al.
showed that immunization of mice with a candidate subunit vaccine consisting of SARS-CoV-2 RBD and Fc fragment of human IgG, as an immunopotentiator, elicited high titer of RBD-specific antibodies with robust neutralizing activity against both pseudotyped
and live SARS-CoV-2 infections.
DIAGNOSTICS
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Al Ahmad et al
proposes a novel optical method of detecting and reducing SARS-CoV-2 transmission using a light source from a smart phone and a mobile spectrophotometer to enable detection of viral proteins. The proof-of-concept is shown by detecting soluble preparations
of spike protein subunits from SARS-CoV-2, followed by detection of the actual binding potential of the spike protein with its host receptor, ACE2. This technique is combined with DC bias to show that introduction of a current into the system can be used to
disrupt the antigen-antibody reaction, therefore reducing virus transmission by disrupting virus-receptor interactions electrically.
MENTAL HEALTH
·
Niedzwiedz et al
explored the relationship between reporting probable COVID-19 symptoms in April 2020 and psychological distress one, two and three months later. Elevated levels of psychological distress were found up to three months after probable COVID-19, compared
to participants with no likely infection.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley Otten, Drew
Greydanus, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark, Catherine Card, Ruey Su, Paul McLaren
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics /
Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance,
Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, Immunologie,
économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Do Zinc Supplements Enhance the Clinical Efficacy of Hydroxychloroquine?: a Randomized, Multicenter Trial |
Abd-Elsalam, S, Soliman, et al |
Biol Trace Elem Res |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
We aimed to evaluate the effect of combining chloroquine/hydroxychloroquine (CQ/HCQ) and zinc in the treatment of COVID-19
patients. This was a randomized clinical trial conducted at three major University hospitals in Egypt. Clinical recovery after 28 days was achieved by 79.2% in the zinc group and 77.9% in zinc-free treatment group, without any significant difference (p = 0.969).
The need for mechanical ventilation and the overall mortality rates did not show any significant difference between the 2 groups either (p = 0.537 and 0.986, respectively). The age of the patient and the need for mechanical ventilation were the only risk factors
associated with the patients' mortality by the univariate regression analysis (p = 0.001 and < 0.001, respectively). Zinc supplements did not enhance the clinical efficacy of HCQ. |
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Abdulrahman, Abdulkarim, AlSayed, et al |
medRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We aim to assess the efficacy and safety of using Hydroxychloroquine in treatment of COVID-19 patients who are admitted in acute care hospitals in Bahrain.
A random sample of 1571 patients were included, 440 of which received HCQ (treatment group) and 1131 did not receive it (control group). Our results showed that HCQ did not have a significant effect on primary outcomes due to COVID-19 infection when compared
to controls after adjusting for confounders (OR 1.43 95% CI 0.85 to 2.37, P value=0.17). Co-administration of azithromycin had no effect on primary outcomes (OR 2.7 95% CI 0.82 to 8.85 P value =0.10). HCQ was found to be associated with increased risk of hypoglycemia
(OR 10.9 95% CI 1.72 - 69.49, P value =0.011) and diarrhea(OR 2.8, 95% CI 1.4-5.5, P value =0.003), but not QT prolongation(OR=1.92, 95% CI 0.95-3.9, P value =0.06) or cardiac arrhythmia.(OR=1.06, 95% CI 0.55-2.05, P value =0.85). |
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New modeling approaches based on varimax rotation of functional principal components |
Acal, C, Aguilera, et al |
Mathematics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, two new functional Varimax rotation approaches are introduced. They are based on the equivalence between FPCA of basis expansion of the
sample curves and Principal Component Analysis (PCA) of a transformation of the matrix of basis coefficients. A simulation study and an application with data from the curves of infections by COVID-19 pandemic in Spain are developed to study the performance
of these methods by comparing the results with other existing approaches. |
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Adhikari, EH, Moreno, et al |
JAMA network open |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To evaluate adverse outcomes associated with SARS-CoV-2 infection in pregnancy and to describe clinical management, disease progression, hospital admission,
placental abnormalities, and neonatal outcomes. 3374 pregnant women (mean SD] age, 27.6 6] years) tested for SARS-CoV-2 were delivered, including 252 who tested positive. The cohort included 2520 Hispanic (75%), 619 Black (18%), and 125 White (4%) women.
There were no differences in age, parity, body mass index, or diabetes among women with or without SARS-CoV-2. SARS-CoV-2 positivity was more common among Hispanic women (230 91%] positive vs 2290 73%] negative; difference, 17.9%; 95% CI, 12.3%-23.5%; P < .001).
There was no difference in the composite primary outcome (52 women 21%] vs 684 women 23%]; relative risk, 0.94; 95% CI, 0.73-1.21; P = .64). Early neonatal SARS-CoV-2 infection occurred in 6 of 188 tested infants (3%), primarily born to asymptomatic or mildly
symptomatic women. There were no placental pathologic differences by illness severity. Maternal illness at initial presentation was asymptomatic or mild in 239 women (95%), and 6 of those women (3%) developed severe or critical illness. Fourteen women (6%)
were hospitalized for the indication of COVID-19. |
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Akhtar, W, Olusanya, et al |
Indian Journal of Thoracic and Cardiovascular Surgery |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We describe our experience and early outcomes with critically unwell SARS-CoV-2 patients who required extracorporeal membrane oxygenation (ECMO). A retrospective
cohort study including 18 SARS-CoV-2 patients who required extracorporeal support at St Bartholomew’s Hospital between 1 March 2020 and 31 July 2020. 14 survived (78%) with 4 deaths (22%). The mean duration from hospital admission to intubation was 4.1 ± 3.4
days, mean time from intubation to ECMO 2.3 ± 2 days and mean run on ECMO 17.7 ± 9.4 days. Survivor mean days from intubation to extubation was 20.6 ± 9.9 days and survivor mean days from intubation to tracheostomy decannulation 46.6 ± 15.3 days. Time from
hospital admission to discharge in survivors was a mean of 57.2 ± 25.8 days. |
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Al Ahmad, Mahmoud, Mustafa, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study proposes a novel optical method of detecting and reducing SARS-CoV-2 transmission. The technique being
proposed uses a light source from a smart phone and a mobile spectrophotometer to enable detection of viral proteins in solution or paper as well as protein-protein interactions. The proof-of-concept is shown by detecting soluble preparations of spike protein
subunits from SARS-CoV-2, followed by detection of the actual binding potential of the spike protein with its host receptor, the angiotensin-converting enzyme 2 (ACE2). This technique is combined with DC bias to show that introduction of a current into the
system can be used to disrupt the antigen-antibody reaction, suggesting that the proposed extended technique can be a potential means of not only detecting the virus, but also reducing virus transmission by disrupting virus-receptor interactions electrically. |
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Al Nsour, MAA, Khader, et al |
Pan African Medical Journal |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study aimed to use the Curve Estimation Procedure to assess the pattern and trend of COVID-19 spread in the countries
of the Eastern Mediterranean Region (EMR) by finding the model best fit for the observed COVID-19 data in each country between 20 February 2020-21 April 2020. During this observed period, the total number of confirmed cases, recovered cases, and deaths in
the region were 138673, 71343, and 6291, respectively. The overall fatality rate in the region was 4.5%. The quadratic model and the cubic model follows the observed data points fairly well during the observed time period in five and nine countries, respectively. |
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Aldila, D |
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Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions
de sant&eacute; publique |
In this paper, a system of ordinary differential equation approach is developed to understand the spread of COVID-19.
We first formulate the dynamic model by dividing the human population based on their health status, awareness status, and also including the free virus on the environment. We provide a basic analysis of the model regarding the well-posed properties and how
the basic reproduction number can be used to determine the final state of COVID-19 in the population. A Pontryagin Maximum's Principle used to construct the model as an optimal control problem in a purpose to determine the most effective strategies against
the spread of COVID-19. Three control strategies involved in the model, such as media campaign to develop an awareness of individuals, medical masks to prevent direct transmission, and use of disinfectant to reduce the number of free virus in the environment.
Through numerical simulations, we find that the time-dependent control succeeds in reducing the outbreak of COVID-19. Furthermore, if the intervention should be implemented as a single intervention, then the media campaign gives the most effective cost strategy. |
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CoVID-19 symptoms analysis of deceased and
recovered cases using Chi-square test |
Al-Najjar, D, Al-Najjar, et al |
European review for medical and pharmacological sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This paper aims to show the relationship between COVID-19 symptoms and patients' status including recovered and deceased
cases. The study uses different CoVID-19 patients' information from different countries, the dataset contains 13174 patients with 730 as recovered and 34 cases as deceased. The Chi-square test is adopted with asymptotic significance level to show the strength
of each symptom on recovered and deceased cases independently. The study found that the recovered cases are associated with different symptoms based on the patient history, where the deceased cases showed that high fever is not responsible for increasing the
number of deceased cases. In addition, the use of symptoms will not give evidence of the patients' status, and therefore gender, age, reason of infection and patients' province are more dominant in determining the status of patients. |
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Alshiyab, DM, Al-Qarqaz, et al |
Ann Med Surg (Lond) |
Healthcare Response | Réponse des soins de santé |
COVID-19 pandemic had an important impact on various aspects of care for dermatology patients especially those on systemic
therapy. This study demonstrated limited access to specialist care, inability to do lab tests and discontinuation of treatment during lockdown. Some patients (42%) had flare up of their skin condition as a result. |
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Amaku, M, Covas, et al |
Infect Dis Model |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
We modelled and simulated a test-trace-and-quarantine strategy to control the COVID-19 outbreak in the State of São
Paulo, Brasil. Two alternative strategies combined with economic evaluations were simulated. One strategy included indiscriminately testing the entire population of the State, reaching more than 40 million people at a maximum cost of 2.25 billion USD, that
would reduce the total number of cases by the end of 2020 by 90%. The second strategy investigated testing only symptomatic cases and their immediate contacts - this strategy reached a maximum cost of 150 million USD but also reduced the number of cases by
90%. |
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Amri, A, Abidli, et al |
Pan African Medical Journal |
Mental Health |
|
The aim is to assess the magnitude results of burnout and associated factors among primary school teachers in Kenitra
in Morocco during this confinement period. This is a cross-sectional study, which was conducted during the two months of April and May 2020. Burnout was evaluated by the Maslach Burnout Inventory (MBI) with 16 items, specific to the context of Moroccan teachers
and the factors of stress were assessed using a questionnaire developed by the research team. The MBI revealed that 68 teachers (54%) were victims of burnout, of which 47 (38%) had a low level; 15 (12%) had a moderate level and six (5%) had a severe burnout.
Logistic regression analysis has shown that the risk factors for burnout during this confinement period are: the use and development of skills in new information and communication technologies (p<0,05); work/family conflict (p<0,05); social support (p<0,05);
and the workload related to distance education (p≤0,05). |
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Arceda, MAM, Laura, et al |
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Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this work, we present an analysis of time series of COVID-19 confirmed cases with Multiplicative Trend Exponential
Smoothing (MTES) and Long Short-Term Memory (LSTM). We evaluated the results utilizing COVID-19 confirmed cases data from countries with higher indices as the United States (US), Italy, Spain, and other countries that presumably have stopped the virus, like
China, New Zealand, and Australia. Additionally, we used data from a Git repository which is daily updated, when we did the experiments we used data up to April 28th. We used 80% of data to train both models and then, we computed the Root Mean Square Error
(RMSE) of test ground true data and predictions. In our experiments, MTES outperformed LSTM, we believe it is caused by a lack of historical data and the particular behavior of each country. To conclude, we performed a forecasting of new COVID-19 confirmed
cases using MTES with 10 days ahead. |
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Armann, Jakob Peter, Unrath, et al |
medRxiv |
Epidemiology| Épidémiologie Immunology | Immunologie |
We performed a SARS-CoV-2 seroprevalence study in students and teachers at two time points in June and October 2020,
respectively. Students grade 8-11 and their teachers in 13 secondary schools in eastern Saxony, Germany, were invited to participate in the SchoolCoviDD19 study. Blood samples were collected in May/June 2020 after the reopening of the schools following the
March 2020 lockdown, and again in September/October 2020, 4 weeks after the end of the summer holidays. SARS-CoV-2 IgG were assed using chemiluminescence immunoassay technology. 1538 students and 507 teachers were initially enrolled, and 1334 students and
445 teachers completed both study visits. The seroprevalence for SARS-CoV-2 antibodies was 0.6% in May/June and the same in September/October. Even in schools with reported Covid-19 cases before the lockdown of March 13th no clusters could be identified. Of
12 persons with positive serology 5 had a known history of confirmed COVID-19; 23 out of 24 participants with a household history of COVID-19 were seronegative. By using a combination of three different immunoassays we could exclude 16 participants with a
positive or equivocal results after initial testing. Schools do not play a crucial role in driving the SARS-CoV-2 pandemic in a low prevalence setting. Transmission in families occurs very infrequently, and the number of unreported cases is low in this age
group. These observations do not support school closures as a strategy fighting the pandemic in a low prevalence setting. |
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Ashraf, Sohaib, Ashraf, et al |
medRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
Honey and Nigella sativa (HNS) have established antiviral properties. Hence, we investigated efficacy of HNS against
COVID-19. We conducted a multicenter, placebo-controlled, randomized clinical trial at 4 centers in Pakistan. RT-PCR confirmed COVID-19 adults showing moderate or severe disease were enrolled in the study. Patients were randomly assigned in 1:1 ratio to receive
either honey (1 gm/Kg/day) and Nigella sativa seeds (80 mg/Kg/day) or placebo up-to 13 days along with standard care. Three hundred and thirteen patients - 210 moderate and 103 severe - underwent randomization from April 30 to July 29, 2020. HNS resulted in
∼50% reduction in time taken to alleviate symptoms as compared
to placebo (Moderate (4 versus 7 days), Hazard Ratio HR]: 6.11; 95% Confidence Interval CI]: 4.23-8.84, P<0.0001 and severe (6 versus 13 days)HR: 4.04; 95% CI, 2.46-6.64, P<0.0001). HNS also cleared the virus 4 days earlier than placebo group in moderate (6
versus 10 days,HR: 5.53; 95%CI: 3.76-8.14, P<0.0001) and severe cases (8.5 versus 12 days,HR: 4.32; 95%CI: 2.62-7.13, P<0.0001). HNS further led to a better clinical score on day 6 with normal activity resumption in 63.6% versus 10.9% among moderate cases
(OR: 0.07; 95%CI: 0.03-0.13, P<0.0001) and hospital discharge in 50% versus 2.8% in severe cases (OR: 0.03; 95%CI: 0.01-0.09, P<0.0001). In severe cases, mortality rate was four-fold lower in HNS group than placebo (4% versus 18.87%, OR: 0.18; 95%CI: 0.02-0.92,
P=0.029). No HNS-related adverse effects were observed. |
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Audirac, Michelle, Tec, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
We offer a statistical analysis of the relative effectiveness of the timing of both official stay-at-home orders and
population mobility reductions, offering a distinct (but complementary) dimension of evidence gleaned from more traditional mechanistic models of epidemic dynamics. Specifically, we use a Bayesian hierarchical model fit to county-level mortality data from
the first wave of the pandemic from Jan 21 2020 through May 10 2020 to establish how timing of stay-at-home orders and population mobility changes impacted county-specific epidemic growth. We find that population mobility reductions generally preceded stay-at-home
orders, and among 356 counties with a pronounced early local epidemic between January 21 and May 10 (representing 195 million people and 32,000 observed deaths), a 10 day delay in population mobility reduction would have added 16,149 (95% credible interval
CI] 9,517 24,381) deaths by Apr 20, whereas shifting mobility reductions 10 days earlier would have saved 13,571 (95% CI 8,449 16,930) lives. Analogous estimates attributable to the timing of explicit stay-at-home policies were less pronounced, suggesting
that mobility changes were the clearer drivers of epidemic dynamics. |
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Aughterson, Henry, McKinlay, et al |
medRxiv |
Mental Health |
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This was a qualitative study deploying in-depth, individual interviews, to explore the psychosocial well-being of health
and social care professionals working during the COVID-19 pandemic. This study involved 25 participants from a range of frontline professions in health and social care. From the analysis, we identified 5 overarching themes: communication challenges, work-related
stressors, support structures, personal growth, and individual resilience. The participants expressed difficulties such as communication challenges and changing work conditions, but also positive factors such as increased team unity at work, and a greater
reflection on what matters in life. |
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Angiotensin converting enzyme genotypes and mortality from COVID-19: An ecological
study |
Aung, AK, Aitken, et al |
Journal of Infection |
Epidemiology| Épidémiologie |
We undertook an ecological study to examine the association between ACE genotypes and COVID-19 mortality across 25
countries to represent different geographical regions of the world. The population frequencies of ACE genotypes were drawn from previously published reports and data on COVID-19-related mortality were extracted from ‘Worldometer’. The frequency of II genotype
is highest in east Asian countries and lower among the European and African countries. An inverse geographical distribution frequency was noted for DD genotype. Increasing II genotype frequency was significantly associated with decreased COVID-19 mortality
rates (adjusted incident rate ratio IRR] 0.3, 95% confidence interval CI]: 0.002–0.7, p = 0.03). However, no association was found between DD genotype frequency and COVID-19 mortality rates (adjusted IRR 4.3, 95%CI: 0.5–41.2, p = 0.2). |
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Azimi, M, Hasheminasab, et al |
Trials |
RCT |
The protocol describes the design of an ongoing randomized controlled trial to establish the evidence for the usage
of water extract of M. communis fruit in clinically suspected COVID-19 disease and identify any safety concerns. |
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COVID-19: Mitigation Measures and the Aftershock in an Overlapping
Generations Model |
Bairoliya, Neha, Imrohoroglu, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique Economics | Économie |
Using an overlapping generations model, we show that a targeted lockdown policy based on preexisting health conditions
would have reduced the economic severity of the pandemic by 22.5% without compromising health outcomes. Our model predicts that after the mandatory lockdown measures are lifted, individuals respond to the continued infection risk by lowering their labor supply,
resulting in a slower economic recovery where output remains 2.16% below trend. The model predicts significant heterogeneity in agent’s behavioral response to the lingering infection risk. While the vulnerable wealth rich can be convinced to stay home by transfers
equalling 10% of their earnings, it would require 35% of own earnings to compensate the vulnerable wealth poor. In aggregate, the vulnerable working age individuals who are at risk of infections can be convinced to self-isolate at a cost of 0.43% of GDP, once
the lockdown is lifted. |
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Banerjee, A, Arrandale, et al |
Acute medicine |
Clinical data| Données cliniques |
Case series of two pregnant women who presented with dyspnoea and hypoxia during the COVID-19 pandemic. Two pregnant
women presented with dyspnoea and hypoxia. The first case had COVID-19 infection in the 3rd trimester. The second case had an exacerbation of asthma without concurrent COVID-19. |
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Banerjee, A, Mukherjee, et al |
J Assoc Physicians India |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
A retrospective observational study was conducted at the Department of Microbiology, ID and BG Hospital, Kolkata to
determine the prevalence of COVID-ap amongst HCWs. Out of the 274 HCW tested, 75 (27%) of total HCWs were found to be positive. Routine screening of both symptomatic as well as asymptomatic hospital staff is essential for early diagnosis to prevent transmission
of COVID 19 infection. |
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Banks, CJ, Colman, et al |
medRxiv |
Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions
de sant&eacute; publique |
According to the model, most transmission was occurring “locally” (i.e. in the model, 80% of transmission events occurred
within spatially defined “communities” of approximately 100 individuals). Early reduction in long distance movements does not reduce death rates significantly. |
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Bansal, P, Margekar, et al |
J Assoc Physicians India |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study serum amylase and serum lipase levels were analysed in relation to severity of COVID-19 and mortality.
Serum amylase or lipase did not correlate with severity of COVID-19 or its mortality. |
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Optimal shutdown strategies for COVID-19 with economic
and mortality costs: BC as a case study |
Barlow, MartinT, Marshall, et al |
medRxiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique Economics | Économie |
In this paper a model with both epidemiological and economic content is created to balance the competing claims of
saving lives and the high economic cost of shutdowns. The model indicates that an oscillating policy of strict and mild shutdowns is less effective than a policy which maintains a moderate shutdown level. |
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Unheeded SARS-CoV-2 protein? Look deep into negative-sense
RNA |
Bartas, Martin, Volna, et al |
bioRxiv |
Coronavirology| Coronavirologie |
An exploration the coding potential of negative-strand SARS-CoV-2 intermediate for its potential to contain additional
protein coding-loci revealed a brand new functional SARS-CoV-2 protein-coding loci called it Avo1 (Ambient viral ORF1). which may play an important role in the viral lifecycle and COVID-19 pathogenesis |
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The newly introduced SARS-CoV-2 variant A222V is
rapidly spreading in Lazio region, Italy |
Bartolini, Barbara, Rueca, et al |
medRxiv |
Coronavirology| Coronavirologie |
A new SARS-CoV-2 clade (GV) characterized by S substitution A222V, first reported from Spain in March, is rapidly spreading
across Europe. To establish the A222V variant involvement in the infection rise in Italy, all GISAID sequences from Italy and those from our Laboratory (Lazio) in the period June-October were analysed. A222V, first recognized in August, represents 11.2% of
sequences in this period, reaching 100% of autochthonous sequences in October, supporting increased GV circulation in Italy.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis study was supported by funds to the
Istituto Nazionale per le Malattie Infettive (INMI) Lazzaro Spallanzani IRCCS, Rome, Italy, from the Ministero della Salute (Ricerca Corrente, linea 1; COVID-2020,12371817), the European Commission Horizon 2020 (EU project 101003544 CoNVat; EU project 101005111-DECISION;
EU project 101005075-KRONO), the European Virus Archive GLOBAL (grants no. 653316 and no. 871029). and 3rd Health Programme JA: EU project 848096 SHARPAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or
ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This work was performed within the framework of the COVID-19 outbreak response and surveillance
program, and has been approved by the INMI Ethical Committee (Comitato Etico INMI Lazzaro Spallanzani IRCCS/Comitato Etico Unico Nazionale Covid-19; issue n. 214/20-11-2020).
https://www.inmi.it/servizio/comitato_eticoAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical
trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note:
if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant
EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesSequence data have been posted on GISAID
www.gisaid.org |
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Basu, S, Bhattacharyya, et al |
Indian Journal of Biochemistry and Biophysics |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Pediatric Inflammatory Multisystem Syndrome temporarily associated with SARS-CoV-2 (PIMS-TS) is a post COVID-19 multisystem
inflammatory syndrome in children and adolescents <21 years of age. It is slowly emerging in India with clinical features overlapping with Kawasaki Disease (KD) and Toxic Shock Syndrome (TSS). CRP remains a useful, inexpensive marker for PIMS-TS diagnosis
and clinical progression. |
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Bavdekar, SB, Chandrasekaran, et al |
J Assoc Physicians India |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
ICMR's HCQ prophylaxis regimen was initiated by 125 (68.7%) participants with 31 (17%) initiating 'No prophylaxis'.
The proportions with an AE was similar with ICMR regimen (5.9%) and no prophylaxis (6.5%). |
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Changing case fatality risk for COVID-19 over time
in selected European countries |
Becher, Heiko, Olszewski, et al |
medRxiv |
Epidemiology| Épidémiologie |
The objective of this study was to illustrate the development of the case fatality risk (CFR) for COVID-19 over time.
Incomplete ascertainment of early cases means that reliable CFR estimates should not be based on cumulative numbers from the beginning of the pandemic but rather be based on more recent data only. |
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Psychiatric side effects of chloroquine in covid-19 patients: Two case reports |
Benjelloun, R, Otheman, et al |
Pan African Medical Journal |
Clinical data| Données cliniques |
Here, we present the description of two COVID-19 patients who showed psychiatric side effects after chloroquine treatment.
One patient expressed psychotic symptoms and the other one experienced acute and intense anxiety. |
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Berastegui-Cabrera, J, Salto-Alejandre, et al |
J Infect |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
A prospective multicentre cohort study of consecutive COVID-19 adult patients aimed to identify the factors associated
with the detection of SARS-CoV-2 RNAemia at hospital admission and if its presence is associated with an unfavourable outcome. Patients with SARS-CoV-2 RNAemia required more frequently ICU admission (45.50% vs. 8.2%, P = 0.005), showed more frequently acute
respiratory distress syndrome (ARDS) (54.5% vs. 9.8%, P = 0.01) and required in more cases invasive mechanical ventilation (36.4% vs. 6.6%, P = 0.018). Mortality (36.4% vs. 4.9%, P = 0.007) and unfavourable outcome (63.6% vs. 13.1%, P = 0.001), were also more
frequent in patients with SARS-CoV-2 RNAemia |
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Which policies most effectively reduce SARS-CoV-2
transmission in schools? |
Bershteyn, Anna, Kim, et al |
medRxiv |
Transmission Public health interventions*| Interventions de sant&eacute; publique |
This study sought to determine which policies had the greatest impact on reducing the risk of in-school transmission
in NYC. Adherence to infection control measures (facemasks, physical distancing, enhanced indoor ventilation, cohorting of small groups, and hand hygiene) is the highest priority for safe school re-opening. All-remote instructions, schedules that rotate in-person
and remote instruction, daily symptom screening, and testing 10-20% of students and staff weekly or monthly are all less effective. |
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Bianchi, A, Mazzoni, et al |
Radiol Med |
Clinical data| Données cliniques |
The objective of this study was to evaluate the possible association between computed tomography (CT) signs of chronic
cerebrovascular disease (CVD) and mortality in infected patients. CVD-CT (odds ratio 1.6, 95% C.I. 1.2-2.1, p = 0.001) was associated with increased risk of mortality. |
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Anticoagulation in COVID-19: Effect of Enoxaparin, Heparin, and Apixaban on Mortality |
Billett, HH, Reyes-Gil, et al |
Thrombosis and haemostasis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study investigated whether anticoagulation improves survival in COVID-19 and if this improvement in survival is
associated with disease severity. This cohort study simulated an intention-to-treat clinical trial, by analyzing the effect on mortality of anticoagulation therapy chosen in the first 48 hours of hospitalization. Adjusted logistic regression analyses demonstrated
a significant decrease in mortality with prophylactic use of apixaban (odds ratio OR] 0.46, p = 0.001) and enoxaparin (OR = 0.49, p = 0.001). Therapeutic apixaban was also associated with decreased mortality (OR 0.57, p = 0.006) but was not more beneficial
than prophylactic use when analyzed over the entire cohort or within D-dimer stratified categories. Higher D-dimer levels were associated with increased mortality (p 10 μg/mL) derived the most benefit. There was no increase in transfusion requirement with
any of the anticoagulants used. |
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Clonal hematopoiesis is associated with risk of severe
Covid-19 |
Bolton, KellyL, Koh, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study examined the role of hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) and whether CH
predisposes to severe Covid-19 or other infections. Among 515 individuals with COVID-19, it was found that CH was associated with severe Covid-19 outcomes (OR=1.9, 95%=1.2-2.9, p=0.01). Further explored the relationship between CH and risk of other infections
in 14,211 solid tumor patients. CH was significantly associated with risk of Clostridium Difficile (HR=2.0, 95%CI: 1.2-3.3, p=6×10−3) and Streptococcus/Enterococcus infections (HR=1.5, 95% CI=1.1-2.1, p=5×10−3). These findings suggest a relationship between
CH and risk of severe infections that warrants further investigation. |
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Bowman, ER, Cameron, et al |
J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
People infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) display a wide range of illness,
from asymptomatic infection to severe respiratory distress resulting in death. We measured serum biomarkers in uninfected individuals and in individuals with mild, moderate, or critical COVID-19 disease. Levels of monocyte activation (sCD14 and FABP4) and
inflammation (TNFR1 and 2) were increased in COVID-19 individuals, regardless of disease severity. Among patients with critical disease, individuals who recovered from COVID-19 had lower levels of TNFR1 and TNFR2 at hospital admission compared to these levels
in patients with critical disease that ultimately died. |
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PMC7687405; The perfect storm: A Case of COVID-19 infection in an adolescent patient
with EVALI |
Bozkanat, KM, Rao, et al |
Respir Med Case Rep |
Clinical data| Données cliniques |
COVID-19 and EVALI share imaging findings and clinical features, including fever, respiratory, and gastrointestinal
symptoms. To our knowledge, the clinical picture in patients presenting with both conditions simultaneously has not been reported. We present the case of a 17-year-old male with COVID-19 and EVALI, his hospital course, and clinical outcome. |
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Brandão, CFS, Vaccarezza, et al |
Sao Paulo medical journal = Revista paulista de medicina |
Healthcare Response | Réponse des soins de santé |
This was a reflective theoretical descriptive study on an educational program based on clinical simulation, with four
practical phases at different performance and complexity levels. Wearing, handling and adequately disposing of personal protective equipment, along with specific respiratory procedures in different healthcare settings up to intensive care for seriously infected
patients were addressed. |
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Brown, CS, Albright, et al |
J Vasc Surg |
Healthcare Response | Réponse des soins de santé |
This study determined the estimated time to recovery for vascular surgery procedures delayed due to COVID-19 in a regional
health system. Median statewide monthly vascular surgical volume for the study period was 439 procedures, with a maximum statewide monthly case volume of 519 procedures. For the month of April 2020, elective vascular surgery procedural volume decreased by
approximately 90%. Significant variability was seen in estimated hospital capacity as well as estimated backlogged cases, with the recovery of elective cases estimated to take approximately 8 months. If hospitals across the collaborative share the burden of
backlogged cases, the recovery could be shortened to approximately 3 months. |
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Bun, Seiko, Kishimoto, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
This study investigated the trends of treatment behavior in the field of pediatrics asthma during the COVID-19 pandemic.
Identified 10,481 inpatients cases in 67 hospitals and 258,911 out-patients cases in 180 hospitals who were diagnosed with asthma. Performed ITS analysis for inpatients. The reduction in the number of patients during this period was estimated to be 232 (P=0.001).
In addition, ITS analysis was performed for patients aged <3 years. The reduced number of patients during this period was estimated to be 155 (P<0.001) |
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Altered Smell and Taste: anosmia, parosmia and the
long impact of Covid-19 |
Burges Watson, DuikaL, Campbell, et al |
medRxiv |
Long-Term Sequelae |
|
The aim of the present study was to document the impact of post Covid-19 alterations to taste and smell. Participants
reported difficulty understanding, explaining and managing altered taste and smell; a lack of interpersonal and professional explanation or support; altered eating; appetite loss, weight change; loss of pleasure in food, eating and social engagement; altered
intimacy and an altered relationship to self and others. These findings suggest altered taste and smell with Covid-19 lead to a severe disruption to daily living that impacts on psychological well-being and health. |
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Burn, Edward, Sena, et al |
medRxiv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study estimated the proportion of patients hospitalized with COVID-19 who undergo dialysis, tracheostomy, and
extracorporeal membrane oxygenation (ECMO). 240,392 patients hospitalized with COVID-19 were included. Across the six databases, 9,703 (4.04% 95% CI: 3.96% to 4.11%]) patients received dialysis, 1,681 (0.70% 0.67% to 0.73%]) had a tracheostomy, and 398 (0.17%
95%CI: 0.15% to 0.18%]) patients underwent ECMO over the 30 days following hospitalization. Use of ECMO was generally concentrated among patients who were younger, male, and with fewer comorbidities except for obesity. Tracheostomy was used for a similar proportion
of patients regardless of age, sex, or comorbidity. While dialysis was used for a similar proportion among younger and older patients, it was more frequent among male patients and among those with chronic kidney disease. |
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By the, Covid-Aphp-Universities-Inria-Inserm Group |
PloS one |
Healthcare Response | Réponse des soins de santé |
The aim of our retrospective study was to evaluate the earliest COVID19-related signal to anticipate requirements of
intensive care unit (ICU) beds . EMS calls, percentage of positive RT-PCR tests, ambulances used, ED and GP visits of COVID-19 patients were strongly associated (R2 ranging between 0.79 to 0.99, all P<0.001) with COVID-19 ICU patients with an anticipation
delay of 23, 15, 14, 13, and 12 days respectively. Hospitalization did not anticipate ICU bed requirement. A qualitative analysis of the onset of the second wave period of the epidemic (August 1 to September 15, 2020) in the same region provided similar results.
The daily number of COVID19-related telephone calls received by the EMS and corresponding dispatch ambulances, and the proportion of positive RT-PCR tests were the earliest indicators of the number of COVID19 patients requiring ICU care during the epidemic
crisis, rapidly followed by ED and GP visits. |
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Airway antibodies wane rapidly after COVID-19 but
B cell memory is generated across disease severity |
Cagigi, Alberto, Yu, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
This study longitudinally assessed systemic and airway immune responses against SARS-CoV-2 in a well-characterized
cohort of 147 infected individuals representing the full spectrum of COVID-19 severity; from asymptomatic infection to fatal disease. High systemic and airway antibody responses were elicited in patients with moderate to severe disease, and while systemic
IgG levels were maintained after acute disease, airway IgG and IgA declined significantly. In contrast, individuals with mild symptoms showed significantly lower antibody responses but their levels of antigen-specific memory B cells were comparable with those
observed in patients with moderate to severe disease. This suggests that antibodies in the airways may not be maintained at levels that prevent local virus entry upon re-exposure and therefore protection via activation of the memory B cell pool is critical. |
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Carollo, Alessandro, Bizzego, et al |
medRxiv |
Mental Health |
|
This study trained a RandomForest model using 10 variables quantifying individuals' living environment, physical and
mental health statuses to predict how long each of the UK participants (N=382) had been in lockdown. Self-perceived loneliness was found to be the most important variable predicting time in lockdown and, therefore, the aspect most influenced by the time the
participant spent in lockdown. Subsequent statistical analysis showed a significant U-shaped curve for the levels of perceived loneliness (p<0.012), specifically decreasing during the 4th and 5th lockdown weeks. The same pattern was found on data from Greek
citizens (N=129, p<0.041). These results suggest that lockdown measures may have affected how people evaluated their social support while in lockdown, leading to a decreased sense of loneliness. |
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Follow-up of adults with noncritical COVID-19 two months after symptom onset |
Carvalho-Schneider, C, Laurent, et al |
Clinical Microbiology and Infection |
Clinical data| Données cliniques Long-Term Sequelae |
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This study describes the clinical evolution and predictors of symptom persistence during 2 months' follow-up in adults
with noncritical COVID-19 disease. At D30, 68% (103/150) of patients had at least one symptom; and at D60, 66% (86/130) had symptoms, mainly anosmia/ageusia: 59% (89/150) at symptom onset, 28% (40/150) at D30 and 23% (29/130) at D60. Dyspnoea concerned 36.7%
(55/150) patients at D30 and 30% (39/130) at D60. Half of the patients (74/150) at D30 and 40% (52/130) at D60 reported asthenia. Persistent symptoms at D60 were significantly associated with age 40 to 60 years old, hospital admission and abnormal auscultation
at symptom onset. At D30, severe COVID-19 and/or dyspnoea at symptom onset were additional factors associated with persistent symptoms. Up to 2 months after symptom onset, two thirds of adults with noncritical COVID-19 had complaints, mainly anosmia/ageusia,
dyspnoea or asthenia. |
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Post COVID Inflammation
Syndrome: Different Manifestations Caused by the Virus |
Chandrashekara, S, Jaladhar, et al |
J Assoc Physicians India |
Clinical data| Données cliniques |
The present study discusses four cases of COVID infection showing varying clinical features. The post-COVID inflammation
syndrome was associated with non-specific inflammation and post viral arthritis in three cases. One other subject had vasculitis leading to central retinal artery occlusion. |
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Chaudhari, Gunvant, Jiang, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study demonstrates that crowdsourced cough audio samples acquired on smartphones across the world and paired with
COVID-19 status labels can be used to develop an AI algorithm that accurately predicts COVID-19 infection with an ROC-AUC of 77.1% (75.2%-78.3%). Furthermore, this AI algorithm is able to generalize to crowdsourced samples from Latin America and clinical samples
from South Asia, without further training using the specific samples. As more crowdsourced data is collected, further development can be implemented using various respiratory audio samples to create a cough analysis-based AI solution for COVID-19 detection
that can likely generalize globally to all demographic groups in both clinical and non-clinical settings. |
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Cheema, TN, Raja, et al |
European Physical Journal Plus |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study designed an intelligent computing paradigm through Levenberg–Marquardt artificial neural networks (LMANNs)
for solving the mathematical model of COVID-19 disease propagation via human to human interaction. The model is represented with systems of nonlinear ordinary differential equations represented with susceptible, exposed, symptomatic and infectious, super spreaders,
infection but asymptomatic, hospitalized, recovery and fatality classes, and reference dataset of the COVID-19 model is generated by exploiting the strength of explicit Runge–Kutta numerical method for metropolitans of China and Pakistan including Wuhan, Karachi,
Lahore, Rawalpindi and Faisalabad. The created dataset is arbitrary used for training, validation and testing processes for each cyclic update in Levenberg–Marquardt backpropagation for numerical treatment of the dynamics of COVID-19 model. The effectiveness
and reliable performance of the design LMANNs are endorsed on the basis of assessments of achieved accuracy in terms of mean squared error based merit functions, error histograms and regression studies |
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Chen, X, Chen, et al |
BMJ open diabetes research & care |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study investigated the risk factors for the death in patients with COVID-19 with type 2 diabetes mellitus (T2DM).
A total of 1105 inpatients with COVID-19, 967 subjects with without T2DM (n=522 male, 54.0%) and 138 subjects with pre-existing T2DM (n=82 male, 59.4%) were included. The complications were also markedly increased in patients with pre-existing T2DM, including
acute respiratory distress syndrome (ARDS) (48.6% vs 32.3%, p<0.001), acute cardiac injury (ACI) (36.2% vs 16.7%, p<0.001), acute kidney injury (AKI) (24.8% vs 9.5%, p<0.001), coagulopathy (24.8% vs 11.1%, p<0.001), and hypoproteinemia (21.2% vs 9.4%, p<0.001).
The in-hospital mortality was significantly higher in patients with pre-existing T2DM compared with those without T2DM (35.3% vs 17.4%, p<0.001). Moreover, in hospitalized patients with COVID-19 with T2DM, ARDS and coagulopathy were the main causes of mortality,
with an HR of 7.96 (95% CI 2.25 to 28.24, p=0.001) for ARDS and an HR of 2.37 (95% CI 1.08 to 5.21, p=0.032) for coagulopathy. This was different from inpatients with COVID-19 without T2DM, in whom ARDS and cardiac injury were the main causes of mortality,
with an HR of 12.18 (95% CI 5.74 to 25.89, p<0.001) for ARDS and an HR of 4.42 (95% CI 2.73 to 7.15, p<0.001) for cardiac injury. |
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Maladaptive coping with the infodemic and sleep disturbance in the COVID-19 pandemic |
Cheng, C, Ebrahimi, et al |
J Sleep Res |
Mental Health |
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This study examined the prevalence of anxiety and sleep disturbance at the early stage of the pandemic, and unveiled
the information coping process underlying differential susceptibility to COVID-19 infection anxiety and sleep disturbance. The participants were 1,270 adults (47% men, M(age) = 42.82) from the UK and US who completed initial (Time 1) and follow-up (Time 2)
surveys. The prevalence of probable clinically relevant anxiety was 61% and 45% at the first and second time points, and more than half of the participants in this anxiety group also reported mild to severe sleep disturbance. Moreover, 41% of the participants
perceived themselves as not having enough COVID-19-related information and reported higher levels of COVID-19 infection anxiety and sleep disturbance over time than those who perceived themselves as having enough of such information. Moderated mediation analysis
identified two groups who were more vulnerable to both psychological problems: high blunters who sought COVID-19-related information online more frequently and high monitors who sought such information offline less frequently. |
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Cheng, P, Casement, et al |
Sleep |
Mental Health |
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This study evaluated the effect of prior digital cognitive-behavioral therapy for insomnia (dCBT-I) versus sleep education
on health resilience during the COVID-19 pandemic. Insomnia symptoms were significantly associated with COVID-19 related disruptions, and those previously received dCBT-I reported less insomnia symptoms, less general stress and COVID-related cognitive intrusions,
less depression, and better global health than those who received sleep education. Moreover, the odds for resurgent insomnia was 51% lower in the dCBT-I versus control condition. Similarly, odds of moderate to severe depression during COVID-19 was 57% lower
in the dCBT-I condition. |
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Choi, HG, Wee, et al |
Allergy |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We evaluated the association between a history of asthma and mortality and morbidity related to COVID-19. In this study
population, 2.3% (n=96) of the patients were diagnosed with comorbid COVID-19 and asthma, while most (n=3,961) did not have asthma. The mortality rate was 8.3% (8/96) in patients with asthma and 3.0% (118/3,961) in those without asthma (p=0.009). After adjustment
for multiple variables, the risk of mortality was 2.20 (95% CI =1.02-4.76, p=0.045) in patients with asthma compared with those without asthma. Subgroup analyses based on past medical history showed that among the patients with asthma, those with heart failure
and chronic heart disease had an elevated risk of mortality (HR=31.61, 95% CI=4.36-229.05, p<0.001; HR=4.68, 95% CI=1.30-16.84, p=0.018, respectively). |
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Chua, KP, DeJonckheere, et al |
Acad Pediatr |
Public health interventions*| Interventions de santé publique |
To determine which factors are associated with plans for in-person school attendance during the 2020-2021 school year
and with support for 15 school-based COVID-19 risk mitigation measures among parents and guardians. Among 2,202 children in the child-level analysis, in-person school attendance was planned for 71.0%. Such plans were less likely among children of Black respondents
and Asian respondents, and among children with perceived high-risk health conditions. Among 1,126 respondents in the respondent-level analysis, the mean number of measures supported was 8.0 (SD 4.4). Several factors were associated with support, but the magnitude
of associations was generally modest. |
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Prediction of evolution of the second wave of Covid-19
pandemic in Italy |
Ciufolini, Ignazio, Paolozzi, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this paper, we analyze the time evolution of this second wave of Covid-19 pandemic in Italy. In this study there
is also an attempt to account for the effects of the governmental containment measures. |
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Clark, JamesJ, Dwyer, et al |
The Lancet Oncology |
Healthcare Response | Réponse des soins de santé |
We aimed to assess the national impact of COVID-19 on the prescribing of systemic anticancer treatment in England,
immediately after lockdown and after the introduction of new treatments to reduce patient risk. In April, 2020, 2969 registrations were recorded, representing 1417 fewer registrations than in the control period. In May, 2020, total registrations increased
to 3950, representing a 10% reduction compared with the control period. In June, 2020, 5022 registrations were recorded, representing a 15% increase compared with the control period. |
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Clement, ND, Hall, et al |
Bone Joint J |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
The primary aim of this study was to assess the independent association of COVID-19 on postoperative mortality for
patients undergoing orthopaedic and trauma surgery. The secondary aim was to identify factors that were associated with developing COVID-19 during the postoperative period. During the study period, 1,659 procedures were performed in 1,569 patients. There were
68 (4.3%) patients who were diagnosed with COVID-19. There were 85 (5.4%) deaths postoperatively. |
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Colavita, Francesca, Vairo, et al |
medRxiv |
Public health interventions*| Interventions de sant&eacute; publique Diagnostics
/ Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we report preliminary data of the testing algorithm implemented at the points-of-entry (airports and port) in
Lazio Region (Central Italy) on travelers arriving between 17th of August to 15th of October, 2020, using the STANDARD F COVID-19 Antigen Fluorescence ImmunoAssay. Our findings show that the probability of molecular confirmation of Ag RDT positive results
is directly dependent from the semi-quantitative results of this Ag RDT, and that the molecularly confirmed samples actually harbor infectious virus. These results support the public health strategies based on early screening campaigns in settings where molecular
testing is not feasible or easily accessible, using rapid and simple point of care tests, able to rapidly identify those subjects who are at highest risk of spreading SARS-CoV-2 infection. |
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Conte, Danielle Dias, Carvalho, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We evaluated three different commercial point-of-care (POC) LFIAs for anti-SARS-CoV-2 IgM and IgG detection in capillary
whole blood of 100 healthcare workers (HCW) previously tested by RT-PCR: 1) COVID-19 IgG/IgM BIO (Bioclin, Brazil), 2) Diagnostic kit for IgM/IgG Antibody to Coronavirus (SARS-CoV-2) (Livzon, China); and 3) SARS-CoV-2 Antibody Test (Wondfo, China). A total
of 84 positives and 16 negatives HCW were tested. The data was also analyzed by the number of days post symptoms (DPS) in three groups: 59 (n=16). Overall detection was 85.71%, 47.62%, and 44.05% for Bioclin, Livzon, and Wondfo, respectively, with a specificity
of 100%, and 98.75% for Livzon on storage serum samples. Bioclin was more sensitive (p<0.01), regardless of the DPS. Thus, the Bioclin can be used as a POC test to monitor SARS-CoV-2 seroconversion in HCW. |
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Unsupervised learning for economic risk evaluation in the context of Covid-19 pandemic |
Cortes, Santiago, Quintero, et al |
arXiv |
Public health interventions*| Interventions de sant&eacute; publique Economics
| Économie |
The objective of this work is to present a machine learning approach to identify regions that should implement similar
health policies. For that end, we successfully developed a system that gives a notion of economic impact given the prediction of new incidental cases through unsupervised learning and time series forecasting. This system was built taking into account computational
restrictions and low maintenance requirements in order to improve the system's resilience. Finally this system was deployed as part of a web application for simulation and data analysis of COVID-19, in Colombia, available at (this https URL). |
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Couselo-Seijas, M, Almengló, et al |
Eur J Clin Invest |
Clinical data| Données cliniques |
Because epicardial adipose tissue (EAT) express ACE2, we wanted to identify the main factors associated with ACE2 levels
and its cleavage enzyme, ADAM17 in epicardial fat. Epicardial expressed higher levels of ACE2 in comparison with subcutaneous fat cells, which is enhanced by diabetes and obesity presence in patients with cardiovascular disease. Both might be risk factors
for SARS-CoV-2 infection. |
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Cui, Xiangqin, Gallini, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To explore whether the most common inherited cause of chronic kidney disease (CKD), autosomal dominant polycystic kidney
disease (ADPKD), is also an independent risk factor, we studied data from the VA health system and the VA COVID-19-shared resources. Among 61 COVID-19-positive ADPKD patients, 21 (34.4%) were hospitalized, 10 (16.4%) were admitted to ICU, 4 (6.6%) required
ventilator, and 4 (6.6%) died by August 18, 2020. ADPKD was not a significant risk factor for any of the four outcomes in multivariable logistic regression analyses when compared with other cystic kidney diseases and cystic liver-only diseases. In summary,
ADPKD did not significantly alter major COVID-19 outcomes among veterans when compared to other cystic kidney and liver patients. |
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Dalai, CK, Sarkar, et al |
Indian Journal of Biochemistry and Biophysics |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This institute based study sought to assess the acute adverse effects of hydroxychloroquine among in-house health care
professionals who were taking the drug for COVID-19 prophylaxis. The participants (n=54) had taken prophylaxis for 1-7 weeks. The most common adverse effects in the cohort were nausea (02) and skin rash (02). The total number of adverse effects reported by
the participants was 08. One incidence each of gastric upset (01), dizziness (01), pain abdomen (01), and chest tightness (01) was reported. None of the adverse effects were serious. Our study indicates that the prophylactic weekly single dose of hydroxychloroquine
is not associated with any serious adverse effects within 1-7 weeks of initiation. |
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Darmawansyah Alnur, R, Veruswati, et al |
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Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
This study aims to present the effectiveness of large-sale social restriction (LSSR) as the social distancing policy
by analyze the chronological as well as the difference between before and after LSSR implementation in Jakarta, Indonesia. LSSR policy had just implemented over a month after the first multiple cases found. The number of positive confirmed patients increased
significantly after the LSSR (p-value = 0.000; mean difference = -70.532). This study's findings showed that social distancing was not effective to control Covid-19 incidence which indicates the late response of the authorities. |
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Das, Ashis, Mishra, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
This study aimed to examine the extent of reduced access to care among older American adults during the COVID-19 pandemic,
identify predictors and reasons of reduced access. About 30 per cent of respondents delayed or avoided care during the pandemic. In terms of the reasons, the majority of the respondents reported that their visit was either cancelled or rescheduled by the provider;
13.9 per cent thought they could wait, 10.9 per cent could not get an appointment, 9.1 per cent found it unaffordable, and 7.4 per cent were afraid to visit the provider. Respondents reported of reduced access to doctor visits, surgery, prescription filling,
and dental care. |
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Systematic preoperative SARS-CoV-2 screening by chest CT before urological surgery |
Degraeve, A, Tilmans, et al |
Revue medicale de Liege |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
Article in French. The aim of this study was to analyze if a preoperative screening for COVID-19 was key to select
optimal operative candidates and its impact on surgical outcomes. A total of 32 patients underwent elective oncologic (n = 17; 53 %) and emergency (n = 15; 47 %) operations. Screening by chest-CT revealed three cases of COVID-19 (9 %) having led to postpone
two interventions. The third positive COVID-19 patient died of respiratory complications after bladder perforation urgent procedure. Two patients developed compatible post-operatively symptoms with one positive chest-CT but no positive RT-PCR and successful
recovery. |
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Antibody persistency and trend post-SARS-CoV-2 infection
at eight months |
Dehgani-Mobaraki, Puya, Kamber Zaidi, et al |
medRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
Our study aimed at the longitudinal analysis of antibody persistence and its trend over a period of eight months in
a group of COVID-19 recovered patients who tested positive by real-time quantitative PCR for SARS-CoV-2 in the period between the 18th and 30th of March, 2020. Robust IgG antibody persistency was demonstrated in 76.7 % of the subjects (23 out of 30) at eight
months post-infection. The results of this study highlight an important point in terms of the association between humoral immune response and disease severity. |
|
Dell'Edera, A, Borghesan, et al |
World Allergy Organ J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated the putative interplay existing between allergen-specific immunotherapy and COVID-19 infection in a
Hymenoptera venom-allergic population. We evaluated the frequency and severity of COVID-19 infection in a cohort of 211 subjects referring to our center for the regular administration of venom immunotherapy (VIT). We reported only an isolated positivity of
COVID-19 in the overall group; whereas none suffered from upper airway symptoms associated with COVID-19. Even though the demographic characteristics pose a substantial risk for such a population, we suggest that a regular administration of VIT may help in
the development of an immunological milieu able to down modulate the Th1/Th17 environment that has been linked to inflammatory manifestations of COVID-19. |
|
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Lung lesions in severe COVID-19 : anatomoclinical confrontation |
Delvenne, M, de Froidmont, et al |
Revue medicale de Liege |
Clinical data| Données cliniques |
Article in French. We report the fatal outcome of two patients infected by SARS-CoV-2 and exhibiting severe lung lesions
at the thoracic imaging and autopsic examination. We also describe the biosecurity measures to adopt when performing autopsies during the Covid-19 pandemia. |
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Community's Social Construction on Covid-19 Patients with Supervision in Surakarta
Indonesia |
Demartoto, A, Sunesti, et al |
|
Public Health response| Interventions de santé publique |
This research aimed to analyze Surakarta people's interpretation on Covid-19 patient and their social construction
process on Covid-19 patient in Surakarta Indonesia. Externalization process indicated with Surakarta people's early perception on Covid-19 as a new disease known poorly, thereby generating fear and ignorance among them; Objectification process showing people
with varying perspectives on Covid-19 positive patients; and Internalization process finding the subjective reality of Surakarta People on Covid-19 patients affected by objectification stage, later creating interpretation on individual or group having ever
interacted with this virus patient. |
|
Devos, T, Geukens, et al |
Trials |
RCT |
BACKGROUND: The COVID-19 pandemic has imposed an enormous burden on health care systems around the world. In the past,
the administration of convalescent plasma of patients having recovered from SARS and severe influenza to patients actively having the disease showed promising effects on mortality and appeared safe. Whether or not this also holds true for the novel SARS-CoV-2
virus is currently unknown. METHODS: DAWn-Plasma is a multicentre nation-wide, randomized, open-label, phase II proof-of-concept clinical trial, evaluating the clinical efficacy and safety of the addition of convalescent plasma to the standard of care in patients
hospitalized with COVID-19 in Belgium. Patients hospitalized with a confirmed diagnosis of COVID-19 are eligible when they are symptomatic (i.e. clinical or radiological signs) and have been diagnosed with COVID-19 in the 72 h before study inclusion through
a PCR (nasal/nasopharyngeal swab or bronchoalveolar lavage) or a chest-CT scan showing features compatible with COVID-19 in the absence of an alternative diagnosis. Patients are randomized in a 2:1 ratio to either standard of care and convalescent plasma (active
treatment group) or standard of care only. The active treatment group receives 2 units of 200 to 250 mL of convalescent plasma within 12 h after randomization, with a second administration of 2 units 24 to 36 h after ending the first administration. The trial
aims to include 483 patients and will recruit from 25 centres across Belgium. The primary endpoint is the proportion of patients that require mechanical ventilation or have died at day 15. The main secondary endpoints are clinical status on day 15 and day
30 after randomization, as defined by the WHO Progression 10-point ordinal scale, and safety of the administration of convalescent plasma. DISCUSSION: This trial will either provide support or discourage the use of convalescent plasma as an early intervention
for the treatment of hospitalized patients with COVID-19 infection. TRIAL REGISTRATION: ClinicalTrials.gov NCT04429854 . Registered on 12 June 2020 - Retrospectively registered. |
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|
Dhamija, S, Joshi, et al |
International Journal of Current Research and Review |
Healthcare Response | Réponse des soins de santé |
The objective of the survey was to understand the awareness and impact of HCQ/CQ prophylaxis among the health care
workers (HCWs) especially anaesthetists as they are fighting it on the frontline. The survey was taken by 344 HCWs from all over the world. 98% of participants heard about the use of HCQ/CQ prophylaxis against COVID 19 infection. 301 HCWs knew about the side
effects of HCQ/CQ. 54.1% of participants agree there is not adequate research done. |
|
|
Dhibar, DP, Arora, et al |
International journal of antimicrobial agents |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
In this open-label, controlled clinical trial, asymptomatic individuals who had direct contact with laboratory-confirmed
COVID-19 cases or had undertaken international travel in the last 2 weeks were offered HCQ prophylaxis and assigned to PEP (n = 132) or control (n = 185) group. The PEP group received HCQ 800 mg on Day 1 followed by 400 mg once weekly for 3 weeks. Both groups
undertook home quarantine for 2 weeks along with social distancing and personal hygiene. Over 4-week follow-up, 50/317 participants (15.8%) had new-onset COVID-19. The incidence of COVID-19 was significantly (P = 0.033) lower in the PEP (14/132; 10.6%) compared
to the control (36/185; 19.5%) group (total absolute risk reduction, –8.9% points). |
|
|
Dian, S, Simeone, et al |
Clin Nephrol |
Healthcare Response | Réponse des soins de santé |
To prevent the spread of SARS-CoV-2 in our Hemodialysis Unit, we adopted individual protection measures accompanied
by measures to minimize contacts among hemodialysis patients with suspicious symptoms as well as other patients and medical staff. The application of this strategy has resulted in the nearly 200 patients treated in our hemodialysis facilities while there were
only 2 cases of COVID-19 (1% incidence rate) with no deaths. |
|
|
Are we ready for COVID-19’s Golden Passport? Insights
from a Global Physician Survey |
Doraiswamy, PM, Chilukuri, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
Objective: To characterize the global physician community’s opinion regarding immunity passports. The survey asked:
“Digital immunity passports, based on antibody testing, are being considered to offer proof (e.g. via an app or QR code) that a person has developed lasting immunity to COVID-19 and hence can return to work or travel freely. Results: Overall, 52% answered
NO, 17% were UNCERTAIN, and 31% answered YES (p<0.05). EU physicians were more likely to say YES but even among them it did not exceed 35% approval. US physicians (60%) were more likely to say NO (p<0.05) (Figure). |
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PMC7674009; COVID-19 pneumonia accurately detected on chest radiographs with artificial
intelligence |
Dorr, F, Chaves, et al |
Intell Based Med |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Purpose: To investigate the diagnostic performance of an Artificial Intelligence (AI) system for detection of COVID-19
in chest radiographs (CXR), and compare results to those of physicians working alone, or with AI support. Result: Discrimination by the AI system of COVID-19 pneumonia showed an AUROC curve of 0.96 in the validation and 0.83 in the external test set, respectively.
The AI system outperformed physicians in the AUROC overall (70% increase in sensitivity and 1% increase in specificity, p < 0.0001). When working with AI support, physicians increased their diagnostic sensitivity from 47% to 61% (p < 0.001), although specificity
decreased from 79% to 75% (p = 0.007). |
|
Mathematical analysis of the global COVID-19 spread in Nigeria and Spain based on seird
model |
Edeki, SO, Adinya, et al |
Communications in Mathematical Biology and Neuroscience |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, a compartmental model for the transmission dynamics of the new infectious disease referred to as COVID-19
is employed. In the model, the temporal dynamics of the COVID-19 outbreak in Nigeria and Spain are analyzed. It shows that a decrease in the contact rate of the ‘susceptible and the infected’ classes is a considerable condition leading to a decline in 'the
exposed, infected, and death' cases. This decrease is attributed to the control of the possible infecting contacts. The spread patterns for the two considered cases are the same. A lot of measures are needed to be put in place to ensure a corresponding increase
in the 'recovered class.' The COVID-19 outbreak would remain global and endemic if the infecting contact rate is not well controlled. |
|
Automated Western immunoblotting detection of anti-SARS-CoV-2
serum antibodies |
Edouard, Sophie, Jaafar, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We developed an automated Western immunoblotting as a complementary serologic assay for COVID-19. The Jess™ Simple
Western system, an automated capillary-based assay was used. In total, 602 sera were tested including 223 from RT-PCR-confirmed COVID-19 patients, 76 from patients diagnosed with seasonal HCoVs and 303 from coronavirus-negative control sera. In the subset
of sera collected more than 2 weeks after the onset of symptoms, the sensitivity was 94% and the specificity 93%, the latter value probably reflecting cross-reactivity of SARS-CoV-2 with other coronaviruses. |
|
Interfering factors of the emergency and risk of infection
by covid-19 |
Espiritu-Martinez, A, Castro-Llaja, et al |
Utopia y Praxis Latinoamericana |
Public Health response| Interventions de santé publique |
The objective of the study was to analyze the factors that hinder submitting to the state of emergency due to COVID-19
and their relationship in the risk of infection by Coronavirus in informal providers. The survey was used as the technique and two questionnaires as instruments of data collection, one alluding the factors that hinder submitting to the state of emergency for
COVID-19 and the other that measured the risk of infection by coronavirus. The results demonstrate that 45.3% (24) of informal providers present a high risk of infection by Coronavirus. |
|
EXPLORING THE HEALTHY BEHAVIORS OF NIGERIANS DURING
THE COVID-19 PANDEMIC |
Eyisi, Ifeanyichukwu Meek |
medRxiv |
Public Health response| Interventions de santé publique |
This study explored the healthy behaviors of Nigerians during the COVID-19 pandemic and the impact of COVID-19 related
news on healthy behaviors. The healthy behaviors identified included; “social distancing”, “changes in nutrition”, “hand washing or sanitizing”, “exercise”, “increased vigilance from those with comorbidities”, and “use of facemask”. In another analysis, the
impacts of COVID-19 related news on healthy behaviors were; “behavior modification”, “anxious impacts”, and “fake news about COVID-19 caused people to stop listening to COVID-19 related news”. |
|
Pleural effusion in a patient with COVID-19 pneumonia and lung cancer: A case report |
Fahad, AM, Al-Khalidi, et al |
Respiratory Medicine Case Reports |
Clinical data| Données cliniques |
In this report, a 72-year-old patient (known to have lung cancer) present with pleural effusion as possible sequel
of COVID-19 pneumonia. |
|
Association of Toll-like receptor 7 variants with
life-threatening COVID-19 disease in males |
Fallerini, Chiara, Daga, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective We sought to determine whether the two families represent the tip of the iceberg of a subset of COVID-19
male patients. Results Rare TLR7 missense variants were predicted to impact on protein function in severely affected males and in none of the asymptomatic subjects. A gene expression profile analysis in peripheral blood mononuclear cells after stimulation
with TLR7 agonist demonstrated a reduction of mRNA level of TLR7, IRF7, ISG15, IFN-□ and IFN-γ in COVID-19 patients compared with unaffected controls demonstrating an impairment in type I and II INF responses. |
|
Fan, C, Guo, et al |
Reprod Toxicol |
Clinical data| Données cliniques |
Our case study aimed to investigate the neonatal clinical outcomes of the recovered pregnant women from COVID-19 in
China, expecting to provide the clinical references of urgent need for other countries. Overall, we did not find any abnormal pregnancy complications and neonatal outcomes among them. We concluded that excess adverse effect on the fetus development due to
COVID-19 in the recovered pregnant women should be less influential, especially, induce abortion due to the anxiety of COVID-19 treatment should be not advisable. |
|
|
Fan, Xiude, Liu, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Method: We conducted a Mendelian randomization study using data from UK Biobank to explore the association between
alcohol consumption and risk of SARS-CoV-2 infection and serious clinical outcomes in patients with COVID-19. Main outcomes were SARS-CoV-2 positivity and death in COVID-19 patients. Both logistic regression and Mendelian randomization analyses found no evidence
that alcohol consumption was associated with risk of SARS-CoV-2 infection in participants either with or without obesity. However, frequent drinking, especially heavy drinking, was associated with higher risk of death in patients with obesity and COVID-19,
but not in patients without obesity. |
|
|
Ferretti, S, Gatto, et al |
European review for medical and pharmacological sciences |
Healthcare Response | Réponse des soins de santé |
OBJECTIVE: A computerized system of telephone consultation has been experimented at the Pediatric Emergency Department
(ED) of Policlinico Gemelli Hospital in Rome during the outbreak of Coronavirus Disease 2019 (COVID-19). RESULTS: The system allows healthcare workers to establish the medical check-up urgency which may be immediate, within the next 24 hours or scheduled
in the pediatric ward. Therefore, it has been implemented a telephone triage consultation with a standardized method. |
|
|
Fodoulian, L, Tuberosa, et al |
iScience |
Clinical data| Données cliniques Animal model | Modèle animal |
To test whether the olfactory neuroepithelium may represent a target of the virus, we generated RNA-seq libraries from
human olfactory neuroepithelia, in which we found substantial expression of the genes coding for the virus receptor angiotensin-converting enzyme-2 (ACE2), and for the virus internalization enhancer TMPRSS2. ACE2 protein was highly expressed in a subset of
sustentacular cells in human and mouse olfactory tissues. Finally, we found ACE2 transcripts in specific brain cell types, both in mice and humans. Sustentacular cells thus represent a potential entry door for SARS-CoV-2 in a neuronal sensory system that is
in direct connection with the brain. |
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|
Foo, DHP, King, et al |
Hosp Pract (1995) |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique Healthcare Response | Réponse des soins de santé |
In this study, we assessed the detection rate of COVID-19 infection from staff mass testing over a five-week period,
and described our experience of adopting this surveillance screening strategy alongside ongoing contact tracing and symptomatic screening strategies. The implementation of staff surveillance screening strategy detected mild and asymptomatic COVID-19 infections
in HCWs and allowed isolation from work to protect the healthcare workforce in a large non-COVID-19 designated hospital with hybrid status within a short period. Among a total of 3336 staff screened from April 16 to May 20, 2020, 22 HCWs were found to be infected
with COVID-19, including six HCWs who were symptomatic at the time of testing. |
|
|
Galindo, I, Garaigorta, et al |
Antiviral Res |
Therapeutics| Thérapeutique |
This study entailed direct comparison of drug effectiveness against animal and human pathogenic viruses, namely Ebola
(EBOV), African swine fever virus (ASFV), and the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection was potently inhibited by selective estrogen receptor modulators in cells transduced with pseudovirus. |
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|
Galle, Anna, Semaan, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to document the experiences of healthcare professionals globally with the provision
of telemedicine for maternal and newborn healthcare during the COVID-19 pandemic. Among the sample, 58% reported using telemedicine, with the lowest proportion reported by professionals working in low-income countries (24%). Challenges reported technological
barriers, lack of technological literacy, financial and language barriers, lack of nonverbal feedback, and distrust from patients. Maternal and newborn health providers considered telemedicine to be an important alternative to in-person consultations to maintain
care provision during the COVID-19 pandemic. |
|
|
Gallo, LindaA, Gallo, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
Objectives To compare the prevalence of live preterm birth rates during COVID-19 restriction measures with infants
born during the same weeks in 2013-2019 in Queensland, Australia. Results A reduction in planned moderate/late preterm births was observed primarily during the early restriction period compared with the same calendar weeks in the previous seven years. There
was no effect on extremely or very preterm infants, spontaneous preterm births, or stillbirth rates. |
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|
García Garmendia, JL, Ramírez Arcos, et al |
Med Intensiva |
Clinical data| Données cliniques |
We present a retrospective descriptive analysis of the records of 10 intubated critical patients with SARS-CoV-2infection
admitted to the ICU of a district hospital and subjected to mechanical ventilation for over a week. Latent infectivity in critical patients with SARS-CoV-2 after 21 days of disease has not been sufficiently established. Persistent viral RNA levels are evidenced
beyond four weeks in the more seriously ill cases. The confirmation of two consecutively negative rRT-PCR tests and the detection of IgG antibody titers could be regarded as a valid strategy in deciding patient isolation withdrawal |
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|
Gathani, T, Clayton, et al |
Br J Cancer |
Healthcare Response | Réponse des soins de santé |
Routinely collected NHS England Cancer Waiting Time data were analysed to compare activity for breast cancer in the
first 6 months of 2020 compared to the same time period in 2019. The number of referrals for suspected breast cancer was 28% lower, and the number of patients who received their first treatment for a breast cancer diagnosis was 16% lower. |
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|
Gaye, Bamba, Diop, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
We conducted a cohort study on all emergency medical consultations over a five-year period, January 2016 to July 2020,
from SOS Medecins in Dakar, Senegal. Firstly, we investigated how the pattern in emergency consultation differed from March to July 2020 compared to previous years. The type of consultations between the months of January and July were similar from 2016 and
2019; however, in 2020, there was a drop among the numbers of infectious disease consultations, particularly from April to May 2020 when sanitary measures for COVID-19 were applied. |
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Gilbert, A, Piazza, et al |
Revue medicale de Liege |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
This article aims to describe the experience of the University Hospital of Liège (CHU Liège) during the COVID-19 outbreak
and demonstrates the efficiency of advanced triage centers to regulate hospital admissions from the emergency department (ED). Results: during the study period, 3,094 patients were admitted to the specific COVID-19 centers of the CHU Liège. This represents
3,431 visits among which 337 were classified as readmission visits. The sensitivity and specificity of the triage centers to determine the need for hospitalization were, respectively, estimated at 87,9 % and 93,4 % |
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Ginex, Tiziana, Garaigorta, et al |
bioRxiv |
Therapeutics| Thérapeutique |
Authors carried out a hierarchical in silico/in vitro protocol which successfully combines virtual and biological screening
to speed up the identification of host-directed therapies against COVID-19 in an effective way. Three different potentially repurposable drugs interfering with viral entry, cepharantine, imatinib and efloxate, have been identified. |
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Giraldo, JH, Bouwmans, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, we model the number of new cases of the Coronavirus Disease 2019 (COVID-19) as a problem of reconstruction
of time-varying graph signals. To this end, we proposed a new method based on the minimization of the Sobolev norm in graph signal processing. Authors prove the benefits of the convergence rate of the Sobolev reconstruction method by relying on the condition
number of the Hessian associated with the underlying optimization problem of our method. |
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|
Glaubitz, Alina, Fu, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
We incorporate into the epidemiological process with an evolutionary game theory model that governs the evolution of
social distancing behavior. We find interesting oscillatory dynamics of social distancing accompanied with waves of infection. Moreover, the oscillatory dynamics are dampened with a nontrivial dependence on model parameters governing decision-makings and gradually
cease when the cumulative infections exceed the herd immunity. |
|
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Golovkine, GuillaumeR, Roberts, et al |
medRxiv |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
We tested a portable UV-C light-emitting diode disinfection chamber and found that decontamination efficacy depends
on mask model, material and location on the mask. This emphasizes the need for caution when interpreting efficacy data of UV-C decontamination methods. |
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Gómez-Luján, M, Cruzalegui, et al |
Jpn J Infect Dis |
Clinical data| Données cliniques |
We present two cases of patients with Fabry disease who had an infection by COVID-19. In the two cases presented, they
presented mild forms of COVID-19. Although the role of the X chromosome mutation in FD on the development of severe forms of COVID-19 is unknown; in the cases presented, it is suggested that it may play a protective role in the development of COVID-19. |
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COVID-19 pandemic in Berlin and Brandenburg - A hospital survey from nursing management
perspective |
Gräske, J, Lengert-Brzozowski, et al |
Pflege |
Healthcare Response | Réponse des soins de santé |
The aim of the present study is to evaluate and compare the current status of all hospitals in both Berlin and Brandenburg.
At the time of the survey, the hospitals in Berlin and Brandenburg were well prepared for the challenges posed by the COVID-19 pandemic. In April 2020, the results indicate that hospitals are well prepared to ensure the health care provision. |
|
Gross, A, Heine, et al |
Br J Radiol |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We report the diagnostic performance of chest CT using structured reporting in a routine clinical setting during the
early phase of the epidemic in Germany. Structured reporting of chest CT with a five-grade scale provided accurate diagnosis of COVID-19. Its use was feasible and helpful in clinical routine. |
|
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Prediction of COVID-19 confirmed cases using gradient boosting regression method |
Gumaei, A, Al-Rakhami, et al |
Computers, Materials and Continua |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study uses gradient boosting regression (GBR) to build a trained model to predict the daily total confirmed cases
of COVID-19. The results are evaluated on a set of evaluation performance measures using 10-fold cross-validation to demonstrate the effectiveness of the GBR method. The results reveal that the GBR model achieves 0.00686 root mean square error, the lowest
among several comparative models. |
|
Gurtoo, A, Agrawal, et al |
J Assoc Physicians India |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to discern their association with severity of illness and mortality in tertiary setup of Delhi, India.
Greater prevalence of symptoms (alone and in combination) and derangements in blood biochemistry are seen in severe COVID-19 compared to mild or moderate cases, and also in non-survivors compared to survivors. |
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|
Hakeem, AR, Baskaran, et al |
J Assoc Physicians India |
Public Health response| Interventions de santé publique |
We aim to study the awareness, attitudes and perceptions of COVID-19 among the adult Indian population. Most of the
respondents were aware of the common symptoms of COVID-19, but worryingly only a third (31%) were aware of the risk of spread from infected asymptomatic individuals, which is a major concern in India. Majority were aware of the modes of virus transmission,
but only two-thirds (68.6%) were aware of the safe physical distance (6 feet) for maintain social distancing. |
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|
Multisystem inflammatory syndrome in children after SARS-CoV-2 infection |
Hartling, UB, Andersen, et al |
Ugeskrift for laeger |
Clinical data| Données cliniques |
Article in Danish. This is a case report of a seven-year-old boy with hyperinflammation and cardiac involvement, compatible
with this disease entity. Antibody tests and symptoms indicated previous severe acute respiratory syndrome coronavirus 2 infection. The patient was treated according to international guidelines with full symptom resolution. |
|
Detection of SARS-CoV-2 in wastewater in Japan during a COVID-19 outbreak |
Hata, A, Hara-Yamamura, et al |
Science of the Total Environment |
Epidemiology| Épidémiologie Surveillance |
Wastewater-based epidemiology (WBE) is potentially effective for early warning of a COVID-19 outbreak. In this study,
presence of SARS-CoV-2 RNA in wastewater samples was investigated and was compared with the number of the confirmed COVID-19 cases in the study area during COVID-19 outbreak in Japan. The detection frequency increased when the number of total confirmed SARS-CoV-2
cases in 100,000 people exceeded 10 in each prefecture; however, SARS-CoV-2 could also be detected at a low frequency even when the number was below 1.0. SARS-CoV-2 in wastewater could be detected in the early stage of the epidemic, even if the number of confirmed
cases potentially underestimates the actual numbers of cases. |
|
Hawton, Keith, Casey, et al |
medRxiv |
Mental Health |
|
We have used well-established monitoring systems in two hospitals in England to investigate trends in self-harm presentations
to hospitals during the early period of the pandemic. A substantial decline in hospital presentations for self-harm occurred during the three months following the introduction of lockdown restrictions. Reasons could include a reduction in self-harm at the
community level and individuals avoiding presenting to hospital following self-harm. |
|
|
Effect of RBD mutation (Y453F) in spike glycoprotein
of SARS-CoV-2 on neutralizing antibody affinity |
Hayashi, Takuma, Yaegashi, et al |
bioRxiv |
Coronavirology| Coronavirologie zoonoses |
Natural selection “adaptation” in the coronavirus can occur during coronavirus amplification in vivo in farmed minks.
Natural selection in such viruses is observed by introduction of mutations in SARS- CoV-2 that are not observed during the growth process in humans. Infection with a mutant (Y453F) of SARS-CoV-2 from farmed minks is known to widely spread among humans. We
investigated the virological characteristics of this SARS-CoV-2 mutant (Y453F) using three-dimensional protein structural analysis. Our experimental study suggests that virus variants with the Y453F mutation partially escaped detection by four neutralizing
monoclonal antibodies. The spread of SARS-CoV-2 variants mediated by millions of infected farmed minks is uncontrolled; consequently, raising a concern that infection of SARS-CoV-2 mutants that cause serious symptoms in humans may spread globally.Competing
Interest StatementThe authors have declared no competing interest. |
|
Hernandez, Alberto, Vinals, et al |
medRxiv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
A prospective case-control study determined by admittance to the hospital based on bed availability. Nine patients
(50%) received ozonated autohemotherapy beginning on the day of admission. Ozonated autohemotherapy was associated with shorter time to clinical improvement (median IQR]), 7 days 6-10] vs 28 days 8-31], p=0.04) and better outcomes at 14-days (88.8% vs 33.3%,
p=0.01). In risk-adjusted analyses, ozonated autohemotherapy was associated with a shorter mean time to clinical improvement (-11.3 days, p=0.04, 95% CI -22.25 to -0.42). |
|
|
Hetherington, Erin, Edwards, et al |
medRxiv |
Public Health response| Interventions de santé publique |
The objective of this study is to understand factors associated with COVID-19 vaccine intentions among parents and
explore reasons underlying decision making. Sixty percent of parents (n=798) intended to vaccinate their children, but 9% (n=113) said they did not intend to vaccinate and 31% (n=410) were unsure. Lower education and income were inversely associated with
intention to vaccinate. Incomplete vaccination history was associated with intention not to vaccinate but not uncertainty. Qualitative responses revealed concerns over vaccine safety and efficacy, long term effects and a rushed vaccination process. |
|
|
How COVID-19 has changed the unselected medical take: an observational study |
Ho, KMA, Anandhakrishnan, et al |
Clinical medicine (London, England) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We retrospectively reviewed patients who were referred to general medicine during March 2020. We compared clinical
outcomes of patients with and without COVID-19. On average, 26 patients were admitted per day. 38% of admitted patients were suspected of COVID-19, with greater numbers of COVID-19 patients in the second half compared to the first half of the month (p<0.001).
Logistic regression analyses showed suspected COVID-19 was an independent predictor for inpatient mortality (odds ratio OR] = 6.09, p<0.001) and 30-day mortality (OR = 4.66, p<0.001). |
|
Holenya, Pavlo, Lange, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Using peptide microarrays, n=24 patient samples and n=12 control samples were screened for antibodies against the entire
SARS-CoV-2 proteome as well as the Spike (S), Nucleocapsid (N), VME1 (V), R1ab, and Protein 3a (AP3A) of the HCoV strains SARS, MERS, OC43 and 229E. While widespread cross-reactivity was revealed across several immunodominant regions of S and N, IgG binding
to several SARS-CoV-2-derived peptides provided statistically significant discrimination between COVID-19 patients and controls. Selected target peptides may serve as capture antigens for future, highly COVID-19-specific diagnostic antibody tests. |
|
|
The effect of remote learning on the mental health of first year university
students in Japan |
Horita, R, Nishio, et al |
Psychiatry research |
Mental Health |
|
We examined the effects of the coronavirus disease 2019 (COVID-19) pandemic on first-year Japanese university students’
mental health by comparing current year's survey results with previous year's results. Accordingly, an online survey was conducted on first-year Gifu University students from April 20 to May 31, 2020. Study results revealed that, despite the emergence of the
COVID-19 pandemic, the number of “high-risk” students and the depression level were lower among the 2020 first-year students compared to previous year's students. However, the 2020 first-year students experienced high academic distress since they had to adapt
to an unfamiliar e-learning environment. © 2020 |
|
Hospital bed allocation strategy based on queuing theory during the covid-19 epidemic |
Hu, J, Hu, et al |
Computers, Materials and Continua |
Healthcare Response | Réponse des soins de santé |
To resolve this contradiction, the rehabilitation department of Nanjing Children's Hospital adjusted its bed allocation
based on the queuing model, with reference to the regional source and classification of the children's conditions in the rehabilitation department ward. The original triple rooms were transformed into a double room to enable the treatment of severely sick
children coming from other places. A M/G/2 queuing model with priority was also applied to analyze the state of patient admissions. |
|
Huang, CJ, Shen, et al |
Socioecon Plann Sci |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Three European countries with severe outbreaks were studied-Germany, Italy, and Spain-to extract spatiotemporal features
and predict the number of confirmed cases. The results verified that COVID-19Net was notably more accurate than the other models. The mean absolute percentage error generated by COVID-19Net was 1.447 for Germany, 1.801 for Italy, and 2.828 for Spain, which
was considerably better than those of the other models. |
|
|
Humer, E, Stippl, et al |
J Med Internet Res |
Healthcare Response | Réponse des soins de santé |
This study aimed to investigate the experiences of psychotherapists with remote psychotherapy in the first weeks of
the COVID-19 lockdown in Austria (between March 24 and April 1, 2020). : Psychotherapists found their experiences with remote psychotherapy (ie, web- or telephone-based psychotherapy) to be better than expected but found that this mode was not totally comparable
to face-to-face psychotherapy with personal contact. Especially, behavioral therapists were found to rate telephone-based psychotherapy less favorably than therapists with other theoretical backgrounds. |
|
|
Huntington, KelseyE, Louie, et al |
medRxiv |
Clinical data| Données cliniques |
To further understand the disease pathogenesis and, consequently, to develop an additional tool for clinicians to evaluate
patients for presumptive intervention authors sought to compare plasma cytokine levels between a range of donor and patient samples grouped by a COVID-19 Severity Score (CSS) based on need for hospitalization and oxygen requirement. |
|
|
Ige, Oluwafemi, Buru, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study compared the performance of the SARS CoV2 antibody test and the real time Polymerase Chain Reaction (Rt-PCR)
in the diagnosis of COVID-19. Authors used the diagnostic test kit by Innovita® Biological Technology CO., LTD China, a total of 521 venous blood samples were collected from consenting patients for the SARS COVID-19 rapid diagnostic kit and Oral and Nasopharyngeal
swabs were collected and analyzed using the real time Polymerase chain reaction technique for nucleic acid detection and quantification. |
|
|
PMC7680021; High affinity of host human microRNAs to SARS-CoV-2 genome: An in
silico analysis |
Jafarinejad-Farsangi, S, Jazi, et al |
Noncoding RNA Res |
Coronavirology| Coronavirologie |
In this study, top miRNAs targeting SARS-CoV-2 genome and top miRNAs targeting differentially expressed genes (DEGs)
in lungs of patients infected with SARS-CoV-2, were predicted. Collectively, more experimental studies especially miRNA-based studies are needed to explore detailed molecular mechanisms of SARS-CoV-2 infection. |
|
Jain, A, Kumar, et al |
Journal of Laryngology and Otology |
Clinical data| Données cliniques |
The objective of this study was to evaluate the occurrence, clinical course and outcomes of olfactory and gustatory
dysfunction in patients with laboratory confirmed coronavirus disease 2019 infection in India. Olfactory and taste dysfunction are prevalent symptoms in coronavirus disease 2019 patients. |
|
|
Favorable Outcome of COVID-19 among African American (AA) Renal Transplant Recipients in
Detroit |
Jarrin Tejada, CD, Zachariah, et al |
Clin Transplant |
Clinical data| Données cliniques |
In this study, authors studied comorbidities and chronic immunosuppresion in hospitalized renal transplant recipients
(RTR) with a positive nasal swab for Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV2) seen 03/01/2020 and 05/01/2020 at the Detroit Medical Center. Despite multiple co-morbidities and chronic immunosuppression, our cohort of African American RTR
had favorable outcomes compared to other reports on COVID-19 in RTR. |
|
Jefferis, JM, Griffith, et al |
Eur J Ophthalmol |
Healthcare Response | Réponse des soins de santé |
In light of this and the COVID-19 pandemic authors aimed to assess whether ophthalmology patients could be safely assessed
without direct contact between the clinician and patient. A virtual clinic model is an effective way of screening for papilloedema in patients referred to the eye clinic with suspicious optic discs. |
|
|
HCQ prophylaxis in COVID-19 did not show any QTc prolongation in Healthcare workers |
Jha, S, Batra, et al |
Indian heart journal |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This was a prospective, cross sectional and observational study conducted on Hydroxychloroquine (HCQ) among Healthcare
Workers (HCWs) at Max Super Speciality Hospital, Saket, New Delhi, India to determine the occurrence of QTc prolongation. This is a first study in the middle of the pandemic which showed that HCQ prophylaxis in young HCWs without comorbidities did not show
any QTc prolongation. |
|
Joshi, A, Sunil Krishnan, et al |
J Genet Eng Biotechnol |
Therapeutics| Thérapeutique |
In this study, authors analyze interaction of beta-sesquiphellandrene (compound belongs to ginger) with spike protein
(Sp) and membrane glycoprotein polyprotein (MPp). This method of computational analysis was found to be rapid and effective, and opens new doors in the domain of in silico drug discovery. |
|
|
Juárez-Saldívar, A, Lara-Ramírez, et al |
Scientia Pharmaceutica |
Therapeutics| Thérapeutique |
In this study, authors employed a virtual screening repurposing strategy to search for potential SARS-CoV-2 Mpro inhibitors.
A combined virtual screening strategy allowed finding chemical compounds with a high potential for the inhibition of SARS-CoV-2 Mpro. |
|
|
Junaid, K, Qasim, et al |
Computers, Materials and Continua |
Therapeutics| Thérapeutique |
Authors discuss the benefits vitamins to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) when treatment
strategies are not yet clear and vaccines are not available. The use of vitamins is beneficial, being immune system restorative, and they also act as anti-COVID agents. |
|
|
The Effect of COVID-19 on Orthopedic Practices and Surgeons in Louisiana |
Kale, NN, Patel, et al |
Orthopedics |
Healthcare Response | Réponse des soins de santé |
This study was performed to analyze the effect that coronavirus 2019 (COVID-19) has had on orthopedic surgeons' practices,
their patients, and orthopedic surgeons themselves through a survey distributed to members of the Louisiana Orthopaedic Association (LOA). The COVID-19 pandemic has had lasting effects on orthopedic surgeons in Louisiana and their practices, with a substantial
decrease in the number of patients treated (90.5%), surgical volume, and revenue (80.6%). |
|
Epidemiology of COVID-19 Outbreak on Cruise Ship Quarantined at Yokohama, Japan, February
2020 |
Kamiya, H, Fujikura, et al |
Emerging Infectious Diseases |
Epidemiology| Épidémiologie Transmission |
To improve the understanding of coronavirus disease (CO-VID-19), authors assessed the epidemiology of an outbreak on
a cruise ship, February 5–24, 2020. This study shows that severe acute respiratory syndrome coronavirus 2 is infectious in closed settings, that subclinical infection is common, and that close contact is key for transmission. |
|
Detection of SARS-CoV-2 from Saliva as Compared to Nasopharyngeal Swabs in Outpatients |
Kandel, C, Zheng, et al |
Viruses |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The aim of this study was to compare the performance of saliva to NPS in an outpatient setting. The use of saliva
as an acceptable alternative to NPS could support the use of widespread surveillance testing for SARS-CoV-2. |
|
Karakas Celik, S, Cakmak Genc, et al |
Int J Immunogenet |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
This study aimed to determine the genetic variations in cytokines and their receptors in relation to COVID-19 pathogenesis
using bioinformatic tools. Further studies are needed to evaluate the importance of these miRNAs and the SNPs. |
|
|
What people share about the COVID-19 outbreak on Twitter? An exploratory analysis |
Karmegam, D, Mapillairaju, et al |
BMJ health & care informatics |
Public Health response| Interventions de santé publique |
This study aims at performing an exploratory study on Twitter to understand the information shared among the community
regarding the COVID-19 outbreak. The results of the study would be useful to focus on the dissemination of the right information and effective communication on Twitter related to health and outbreak management. |
|
ARFIMA Model for Short Term Forecasting of New Death Cases COVID-19 |
Kartikasari, P, Yasin, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
One of the ways in which the death of COVID-19 can be reduced is to produce a prediction model that could be used as
a reference in taking countermeasures. There are various prediction models, from regression to Autoregressive Fractional Integrated Moving Average (ARIMA), but it still shows shortcomings when disturbances occur from extreme fluctuations and the existence
of long memory effects in the form of analysis of a series of data becomes biased, and the power of statistical tests generated for identification become weak. The results of this study prove that ARFIMA (1,0,431.0) with an RMSE of 2,853 is the best model
to predict data on the addition of new cases of patients dying from COVID-19. |
|
Kashiwagi, K, Maeda, et al |
J Nippon Med Sch |
Clinical data| Données cliniques Immunology | Immunologie |
Authors assessed the relationship between disease severity and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
load, IgG antibody levels, and prognostic indicators. A high plasma immunoglobulin G (IgG) index in the early phase of the disease may be associated with disease severity and might serve as a prognostic indicator. |
|
|
Kayikcioglu, M, Kuman Tuncel, et al |
Am J Prev Cardiol |
Mental Health |
|
This study study was conducted to provide insight into the impact of COVID-19 outbreak on heart-healthy lifestyle and
management of patients with a history of premature myocardial infarction (MI). The COVID-19 pandemic significantly affected the heart-healthy lifestyle and anxiety levels of patients with a history of premature MI who were already in regular follow-up in
a tertiary prevention clinic and led to significant avoidance of medical care. |
|
|
Delirium in Older Patients With COVID-19 Presenting to the Emergency Department |
Kennedy, M, Helfand, et al |
JAMA network open |
Clinical data| Données cliniques |
The objective of this study was to determine how frequently older adults with COVID-19 present to the emergency department
(ED) with delirium and their associated hospital outcomes. Findings suggest the clinical importance of including delirium on checklists of presenting signs and symptoms of COVID-19 that guide screening, testing, and evaluation. |
|
Khan, SH, Lindroth, et al |
Crit Care Explor |
Clinical data| Données cliniques |
The objective of tis study was to determine delirium occurrence rate, duration, and severity in patients admitted to
the ICU with coronavirus disease 2019. Delirium without coma occurred in 29.1% of patients admitted to the ICU. |
|
|
Khanal, P, Duyu, et al |
J Ayurveda Integr Med |
Therapeutics| Thérapeutique |
This study aimed to identify the probable modulated pathways by the combined action of AYUSH recommended herbal tea
and golden milk formulation as an immune booster against COVID-19.Results indicated that the recommended herbal formulation not only modulated the pathways involved in boosting the immunity but also modulated the multiple pathways that are contributing to
the progression of multiple disease pathogenesis which would add the beneficial effect in the co-morbid patients of hypertension and diabetes. |
|
|
The Anxiety and Pain of Fibromyalgia Patients during
the COVID-19 Pandemic |
Kharko, AY, Hansford, et al |
medRxiv |
Mental Health |
|
We identified which aspects of the COVID-19 pandemic evoked anxiety among fibromyalgia patients. We found that participants
were most often anxious about “impact on relationships”, “a family member contracting COVID-19”, and “financial hardships”, but on average rated “financial hardship”, “access to medication”, and “home loss/eviction” as evoking the strongest anxiety. Mixed-effects
modelling showed that an increase in pain was significantly associated with an increase in anxiety, when taking into account individual variance and daily caffeine intake. Age and intake of some mild analgesics were also linked to stronger pain. |
|
Kirkland, PD, Frost, et al |
Pathology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study provides examples of how the composition of a viral transport medium (VTM) could have an impact on the outcome
of nucleic acid based testing and, in particular, situations where either there is a need to detect RNA that is not packaged into a nucleocapsid or where RNA constructs may be diluted in a VTM for use as a positive control in an assay or perhaps for proficiency
testing. Finally, users should be reminded that products fit for one purpose may not be suitable for an alternative use. A product that may be eminently suitable for virus culture purposes could result in misleading results if used for nucleic acid-based tests. |
|
|
Knight, T, Edwards, et al |
Acute medicine |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We conducted a retrospective service evaluation between the 3rd March and the 5th May 2020 to describe and characterise
the use of POCUS within an acute care pathway designed specifically for the assessment of suspected or confirmed COVID-19. POCUS was performed in the assessment of 100 patients presenting with suspected COVID-19. POCUS was consistent with COVID-19 infection
in 92% (n = 92) of the patients assessed. Severity, as assessed by POCUS, showed good discriminatory performance to predict all-cause inpatient mortality, death or critical care admission, and escalated oxygen requirements (AUC .80, .80, 82). The risk of all-cause
mortality in patients with scores in lowest quartile was 2.5% (95%CI 0.12- 12.95) compared with 42.9% (95CI 15.8 - 75.0%) in the highest quartile. POCUS assessed severity correlated with length of stay and duration of supplemental oxygen therapy. |
|
|
Knopov, PS, Korkhin, et al |
Cybern Syst Anal |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The dynamics of coronavirus cases is proposed to be modeled using switching regression whose switching points are unknown.
The stepwise process of constructing the regression in time is described. The dynamics of the number of coronavirus cases in Ukraine is analyzed. |
|
|
Assessment of risks associated with SARS-CoV-2 experimental human infection studies |
Kuiper, VP, Rosendaal, et al |
Clin Infect Dis |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
Controlled human infection (CHI) models for the novel coronavirus (SARS-CoV-2) have been proposed as a tool to accelerate
the development of vaccines and drugs. Such models carry inherent risks. Participants may develop severe disease or complications after deliberate infection. Prolonged isolation may negatively impact their wellbeing. Through secondary infection of study personnel
or participant household contacts, the experimental virus strain may cause a community outbreak. We identified risks associated with such a SARS-CoV-2 CHI model and assessed their likelihood and impact and propose strategies that mitigate these risks. In this
report, we show that risks can be minimized with proper risk mitigation strategies; the residual risk however should be weighed carefully against the scientific and social values of such a CHI model. |
|
Kuki, K, Yamaguchi, et al |
Psychiatry Clin Neurosci |
Mental Health |
|
We aim to investigate workers’ mental health state after dealing with nosocomial COVID-19 infections in our psychiatric
hospital. Both the levels of anxiety and depression were significantly higher in workers who had been in close contact with COVID-19 patients and instructed to stay at home than in those who had not (p = 0.013, p = 0.00006, respectively). Anxiety and depression
levels were significantly interacted with the presence of housemates (p = 0.042, p = 0.031, respectively). A multiple regression analysis indicated that being female and staying at home (with close contact) increased the degree of both anxiety and depression
while the presence of housemates increased anxiety levels only. Workers without close contact with COVID-19 patients were divided into three groups: no change in work, transfer to the COVID-19 ward, and transfer to other wards. These instructions did not affect
workers’ anxiety and depression levels (p > 0.05, respectively) |
|
|
Cardiovascular complications and its impact on outcomes in COVID-19 |
Kunal, S, Sharma, et al |
Indian heart journal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We sought to evaluate the cardiovascular (CV) complications and its impact on outcomes in symptomatic COVID-19 patients.
CV complications included acute cardiac injury in 25.9%, heart failure, cardiogenic shock and acute coronary syndrome in 3.7% each, “probable” myocarditis in 2.8% patients. Patients with acute cardiac injury had higher mortality than those without (16/28 [57.1%]
vs 14/78 [17.5%]; P < 0.0001). Multivariate logistic regression analysis showed that acute cardiac injury (OR: 11.3), lymphopenia (OR: 4.91), use of inotropic agents (OR: 2.46) and neutrophil-lymphocyte ratio (OR:1.1) were independent predictors of mortality. |
|
Lambermont, B, Ernst, et al |
Crit Care Explor |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
We conducted a multicenter cohort study to determine the effect of drug therapies on survival in mechanically ventilated
patients with coronavirus disease 2019. Methylprednisolone administration during the first week of mechanical ventilation was associated with a decrease in mortality rate from 48% to 34% (p = 0.01). Mortality was significantly associated with older age, higher
creatinine, lower lymphocyte count, and mean arterial pressure lower than 70 mm Hg on the day of admission. |
|
|
Clinical Psychopathology during COVID-19 Pandemic: Case Reports of First Psychiatric
Presentations |
Lazzari, C, Shoka, et al |
Psychiatria Danubina |
Clinical data| Données cliniques Mental Health |
|
Case reports of 4 individuals experiencing psychiatric symptoms due to COVID-19 stress |
|
Highly functional virus-specific cellular immune response
in asymptomatic SARS-CoV-2 infection |
Le Bert, Nina, Clapham, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
SARS-CoV-2-specific T cells in individuals who clear SARS-CoV-2 infection without symptoms or disease could reveal
non-pathological yet protective characteristics. We therefore compared the quantity and function of SARS-CoV-2-specific T cells in a cohort of asymptomatic individuals (n=85) with that of symptomatic COVID-19 patients (n=76), at different time points after
antibody seroconversion. We detected an increased IFN-γ and IL-2 production in asymptomatic compared to symptomatic individuals after activation of SARS-CoV-2-specific T cells in blood. This was associated with a proportional secretion of IL-10 and pro-inflammatory
cytokines (IL-6, TNF-α and IL-1β) only in asymptomatic infection, while a disproportionate secretion of inflammatory cytokines was triggered by SARS-CoV-2-specific T cell activation in symptomatic individuals. Thus, asymptomatic SARS-CoV-2 infected individuals
are not characterized by a weak antiviral immunity; on the contrary, they mount a robust and highly functional virus-specific cellular immune response. Their ability to induce a proportionate production of IL-10 might help to reduce inflammatory events during
viral clearance. |
|
Lee, Gunsup, Budhathoki, et al |
bioRxiv |
Therapeutics| Thérapeutique |
This study aimed to investigate an antiviral molecule, single chain variable fragment (scFv), against SARS-CoV-2 and
other coronaviruses. 3D8, a recombinant scFv, exhibits broad-spectrum antiviral activity against DNA and RNA viruses owing to its nucleic acid-hydrolyzing property. Here, we report that 3D8 scFv inhibited the replication of SARS-CoV-2, human coronavirus OC43
(HCoV-OC43), and porcine epidemic diarrhea virus (PEDV). Our results revealed the prophylactic and therapeutic effects of 3D8 scFv against SARS-CoV-2 in Vero E6 cells. Immunoblot and plaque assays showed the absence of coronavirus nucleoproteins and infectious
particles in 3D8 scFv-treated cells, respectively. |
|
|
Lee, MH, Verde, et al |
Radiol Case Rep |
Clinical data| Données cliniques |
Two case reports demonstrating the need for enhanced usage of personal protective equipment of face shield, respirator,
gloves, and gown during routine radiologic evaluation who may screen negative for COVID-19 and or atypical COVID-19 symptoms. First case is of a 42-year-old woman undergoing preoperative evaluation for endometrial cancer in the outpatient setting. The second
case is of a 49-year-old woman presenting with abdominal pain, nausea, and vomiting for abdominal CT imaging from the emergency department. Both cases demonstrate typical lung imaging finding of COVID-19. These cases highlight the need for additional precautions
in the outpatient and emergency setting even for patients in whom COVID-19 infection is not suspected. |
|
|
Lehmann, Alexander, Kirchenbaum, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
We show that by introducing irrelevant mega peptide pools as negative controls to account for chance cross-reactivity,
and by establishing the antigen dose-response characteristic of the T cells, one can clearly discern between cognate T cell memory induced by SARS-CoV-2 infection vs. cross-reactive T cell responses in individuals who had not been infected with SARS-CoV-2. |
|
|
Lersy, F, Benotmane, et al |
J Infect Dis |
Clinical data| Données cliniques |
In this single-center study, we describe neurological manifestations of 58 patients, regarding cerebrospinal fluid
(CSF) analysis and neuroimaging findings. Brain MRI abnormalities, especially leptomeningeal enhancement, and increased inflammatory markers in CSF are frequent in patients with neurological manifestations related to COVID-19, whereas SARS-CoV 2 detection
in CSF remained scanty. |
|
|
A model of COVID-19 propagation based on a gamma subordinated negative binomial
branching process |
Levesque, J, Maybury, et al |
Journal of theoretical biology |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We build a parsimonious Crump-Mode-Jagers continuous time branching process of COVID-19 propagation based on a negative
binomial process subordinated by a gamma subordinator. By focusing on the stochastic nature of the process in small populations, our model provides decision making insight into mitigation strategies as an outbreak begins. Our model accommodates contact tracing
and isolation, allowing for comparisons between different types of intervention. We emphasize a physical interpretation of the disease propagation throughout which affords analytical results for comparison to simulations. Combining the asymptotic limit of
our model with Bayesian hierarchical techniques, we provide US county level inferences for the reproduction number from cumulative case count data over July and August of this year. |
|
Li, DF, Shi, et al |
European review for medical and pharmacological sciences |
Healthcare Response | Réponse des soins de santé |
This study aims to discuss the effects of simulation training on improving the pre-examination, triage, prevention,
and control of coronavirus disease 2019 (COVID-19), explain the psychological states of pre-examination and triage staff in general hospitals during the COVID-19 epidemic, and analyze relevant influencing factors. The percent of passing significantly increased
from 65% before the training to 98.33% after training (p<0.05). Training also significantly relieved the anxiety and depression of the nurses (p<0.05). In conclusion, scenario-simulation training can increase the emergency abilities of pediatric nurses in
the prevention and control of the COVID-19 epidemic and relieve the anxiety of nurses. |
|
|
Dynamic changes in anti-SARS-CoV-2 antibodies during SARS-CoV-2 infection and recovery
from COVID-19 |
Li, K, Huang, et al |
Nat Commun |
Clinical data| Données cliniques Immunology | Immunologie |
We analyze the laboratory findings of 1,850 patients to describe the dynamic changes of the total antibody, spike protein
(S)-, receptor-binding domain (RBD)-, and nucleoprotein (N)-specific immunoglobulin M (IgM) and G (IgG) levels during SARS-CoV-2 infection and recovery. The generation of S-, RBD-, and N-specific IgG occurs one week later in patients with severe/critical
COVID-19 compared to patients with mild/moderate disease, while S- and RBD-specific IgG levels are 1.5-fold higher in severe/critical patients during hospitalization. The RBD-specific IgG levels are 4-fold higher in older patients than in younger patients
during hospitalization. In addition, the S- and RBD-specific IgG levels are 2-fold higher in the recovered patients who are SARS-CoV-2 RNA negative than those who are RNA positive. Lower S-, RBD-, and N-specific IgG levels are associated with a lower lymphocyte
percentage, higher neutrophil percentage, and a longer duration of viral shedding. Patients with low antibody levels on discharge might thereby have a high chance of being tested positive for SARS-CoV-2 RNA after recovery. |
|
The Relationship between Weekly Periodicity and COVID-19
Progression |
Li, Sophia |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We investigate the weekly periodicity in the daily reported new cases and new deaths with the implied relationships
to the societal and institutional responses using autocorrelation and Fourier transformation. The results show significant linear correlations between the weekly periodicity and the total cases and deaths, ranging from 50% to 84% for sizable groups of countries
with population normalized deaths spanning nearly three orders of magnitude, from a few to approaching a thousand per million. In particular, the Strength Indicator of the periodicity in the new cases, defined by the autocorrelation with a 7-day lag, is positively
correlated strongly to the total deaths per million in respective countries. The Persistence Indicator of the periodicity, defined as the average of three autocorrelations with 7-, 14- and 21-day lags, is an overall better indicator of the progression of the
pandemic. For longer time series, Fourier transformation gives similar results. This analysis begins to fill the gap in modeling and simulation of epidemics with the inclusion of high frequency modulations, in this case most likely from human behaviors and
institutional practices, and reveals that they can be highly correlated to the magnitude and duration of the pandemic. The results show that there is significant need to understand the causes and effects of the periodicity and its relationship to the progression
and outcome of the pandemic, and how we could adapt our strategies and implementations to reduce the extent of the impact of COVID-19. |
|
PMC7346807; Disappearance of antibodies to SARS-CoV-2 in a -COVID-19 patient after
recovery |
Liu, A, Wang, et al |
Clin Microbiol Infect |
Clinical data| Données cliniques Immunology | Immunologie |
We estimated the longevity of specific antibodies against SARS-CoV-2 in a moderate COVID-19 patient, and reported that
antibodies disappeared within 3 months after the onset of the symptoms. |
|
Liu, R, He, et al |
Chemical Science |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here we report a generalizable method for highly specific and ultrasensitive detection of serum COVID-19-associated
antigens based on an aptamer-assisted proximity ligation assay. The sensor is based on binding two aptamer probes to the same protein target that brings the ligation DNA region into close proximity, thereby initiating ligation-dependent qPCR amplification.
Using this system, serum nucleocapsid protein has been detected quantitatively by converting protein recognition into a detectable qPCR signal using a simple, homogeneous and fast detection workflow in
∼2 hours. In addition, this system has also been transformed
into a universal platform for measuring specific interactions between spike S1 and its receptor ACE2, and more importantly demonstrated the feasibility for screening and investigation of potential neutralizing aptamers. |
|
|
Expressions of SAA, CRP, and FERR in different severities of COVID-19 |
Liu, SL, Wang, et al |
European review for medical and pharmacological sciences |
Clinical data| Données cliniques |
OBJECTIVE: To explore the expression and significance of SAA, CRP and FERR in patients diagnosed with COVID-19. A
total of 225 patients diagnosed with COVID-19 who were admitted to the North Hospital of First Hospital in Changsha, China, from 9th February 2020 to 7th March 2020 were enrolled. Age was an important risk factor for the severity of COVID-19 in the patients.
Compared with the non-severe group, the severe group showed statistical significance in the levels of total protein, albumin, ALT and AST in liver function, UA in renal function, myocardial enzyme CK-MB and LDH, and immunoglobulin IgG and IgM. The levels of
SAA, CRP, and FERR were significantly increased in patients with severe COVID-19. The sensitivity and specificity of the combined detection of the three indicators were higher than those of the detection of any single indicator or two combined indicators. |
|
Liu, Z, Xu, et al |
Signal Transduct Target Ther |
Vaccine Research| Recherche sur les vaccins |
Here, we showed that immunization of mice with a candidate subunit vaccine consisting of SARS-CoV-2 RBD and Fc fragment
of human IgG, as an immunopotentiator, elicited high titer of RBD-specific antibodies with robust neutralizing activity against both pseudotyped and live SARS-CoV-2 infections. The mouse antisera could also effectively neutralize infection by pseudotyped SARS-CoV-2
with several natural mutations in RBD and the IgG extracted from the mouse antisera could also show neutralization against pseudotyped SARS-CoV and SARS-related coronavirus (SARSr-CoV). Vaccination of human ACE2 transgenic mice with RBD-Fc could effectively
protect mice from the SARS-CoV-2 challenge. |
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Lopian, M, Kashani-Ligumsky, et al |
Pediatrics and Neonatology |
Transmission Clinical data| Données cliniques Healthcare Response | Réponse des soins
de santé |
Our goal was to assess the safety of vaginal delivery in women infected with COVID-19 and the risk of neonatal infection.
Data were collected about the outcome of twenty-one women with laboratory-confirmed COVID-19 infection who delivered between March 23, 2020, and May 8, 2020. None required admission to the intensive care unit (ICU) and there were no fatalities. Seventeen delivered
vaginally and four by caesareans. Apgar scores of all neonates were 9 at 1 min and 10 at 5 min. One neonate was diagnosed with COVID-19 infection 24 h after birth. |
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Prognostic Value of C-Reactive Protein in Patients With Coronavirus 2019 |
Luo, X, Zhou, et al |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Data for COVID-19 patients with clinical outcome in a designated hospital in Wuhan, China, were retrospectively collected
and analyzed from 30 January 2020 to 20 February 2020. Of 298 patients enrolled, 84 died and 214 recovered. Most nonsurvivors were male, older, or with chronic diseases. Compared with survivors, nonsurvivors showed significantly elevated white blood cell
and neutrophil counts, neutrophil to lymphocyte ratio (NLR), systemic immune inflammation index (defined by platelet count multiplied by NLR), CRP, procalcitonin, and D-dimer and showed decreased red blood cell, lymphocyte, and platelet counts. Age, neutrophil
count, platelet count, and CRP were identified as independent predictors of adverse outcome. CRP exhibited sensitivity of 90.5%, specificity of 77.6%, positive predictive value of 61.3%, and negative predictive value of 95.4%. CRP was also an independent
discriminator of severe/critical illness on admission with an AUC (0.783) comparable to age (0.828) and neutrophil count (0.729) (both P > .05). |
|
Luykx, Jurjen, Lin, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective: To elucidate associations between neuropsychiatric disorders and COVID-19 susceptibility and severity. n
single-variable MR analysis the most significant and only Bonferroni-corrected significant result was found for BIP-SCZ (a combined anxiety of bipolar disorder and schizophrenia as cases vs. controls): the effect estimate was consistent with increased risk
of COVID-19. In multivariable MR, bipolar disorder was the only phenotype showing a Bonferroni-corrected significant effect on a COVID-19 phenotype, namely severe COVID-19. All sensitivity analyses confirmed the results. |
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Maechler, F, Gertler, et al |
Clin Microbiol Infect |
Epidemiology| Épidémiologie |
We describe epidemiological and clinical characteristics and aim at identifying risk factors for SARS-CoV-2 detection.
In this young population, early-onset presentation of COVID-19 resembled flu-like symptoms, except for smell and/or taste dysfunction. Risk factors for SARS-CoV-2 detection were return from regions with high incidence and contact with confirmed SARS-CoV-2
cases, particularly when tests were administered within the first 2 weeks after contact and/or onset of symptoms. |
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Mahajan, NN, Mathe, et al |
J Assoc Physicians India |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
The aim of this study is to analyze the medical records of HCWs with COVID-19 retrospectively and carry out the analysis
of the data of HCWs with COVID-19 at TNMC and BYL Nair Charitable Hospital (NH, COVID-19 Hospital) in Mumbai. Interim analysis was carried out for the data collected from 6th April to 20th August 2020. Total 3711 HCWs (frontline, 74.32%, non-frontline, 25.68%)
are working at NH Mumbai. We observed 11% prevalence of SARS-CoV-2 infection among HCWs, 4% co-infection and 1% mortality. Majority (85%) of the HCWs with COVID-19 were symptomatic and 15% were asymptomatic. Comorbidities were reported in 19% of HCWs with
COVID-19. Hypertension and Diabetes Mellitus were the most common co-morbidities reported. More than 4% percent of HCWs with COVID-19 were also positive for plasmodium vivax Malaria. |
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Marchetti, Roberto, Stella, et al |
medRxiv |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
U-Earth AIRcel bioreactors are a demonstrated effective biomonitoring system. We implemented a methodological approach
wherein they were placed at various hospitals treating COVID-19 patients in Italy. The objective of the study was to investigate if U-Earth AIRcel bioreactors were effective in monitoring and improving air quality via detection, capture, and destruction of
the SARS-CoV-2 virus, reducing the risk of transmission among healthcare workers. The marked presence of the SARS-CoV-2 virus was found in multiple water samples via the detection of ORF1ab + N and/or E gene involved in gene expression and cellular signaling
of the SARS-CoV virus. The AIRcel bioreactors were able to neutralize the virus effectively as traces of the viruses were no longer found in multiple solute samples after an overnight period |
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Marcos-Jiménez, A, Sánchez-Alonso, et al |
Eur J Immunol |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
SARS‐CoV‐2 infection causes an abrupt response by the host immune system, which is largely responsible for the outcome
of COVID‐19. We investigated whether the specific immune responses in the peripheral blood of 276 patients associated to severity and progression of COVID‐19. At admission, dramatic lymphopenia of T, B and NK cells associated to severity. Conversely, the proportion
of B cells, plasmablasts, circulating follicular helper T cells (cTfh) and CD56‐CD16+ NK‐cells increased. Regarding humoral immunity, levels of IgM, IgA and IgG were unaffected, but when degrees of severity were considered, IgG was lower in severe patients.
Compared to healthy donors, complement C3 and C4 protein levels were higher in mild and moderate, but not in severe patients, while the activation peptide of C5 (C5a) increased from the admission in every patient, regardless their severity. Moreover, total
IgG, the IgG1 and IgG3 isotypes and C4 decreased from day 0 to day 10 in patients who were hospitalized for more than two weeks, but not in patients who were discharged earlier. |
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Martinez-Acuna, Natalia, Avalos-Nolazco, et al |
medRxiv |
Epidemiology| Épidémiologie Immunology | Immunologie |
We evaluated the seroprevalence of anti-SARS-CoV-2 in blood donors in Nuevo Leon, Mexico as a strategy for asymptomatic
case detection of COVID-19 and epidemic progression. We found 77 donors reactive for anti-SARS-CoV-2 IgG (seroprevalence 3.99%) and none of them had reported recent COVID-19 symptoms. Donors aged 18 to 49 years (89.5%) were more likely to be seropositive compared
to those aged 50 years or older (10.5%) (P<0.001). Prevalence of antibodies increased each epidemiological (EPI) week, parallel to the report of confirmed cases by RT-PCR, identifying the highest prevalence between EPI week 33 and 35 (10.2% to 19%). The metropolitan
area of Monterrey recorded the highest number of cases. |
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McDonald, SA, Medford, et al |
Acad Emerg Med |
Epidemiology| Épidémiologie |
The purpose of this study was to develop and internally validate a predictive model to aid in the discrimination of
patients undergoing investigation for COVID‐19. 1026 patients were included in the study collected between March and April 2020. Overall, there was disease prevalence of 9.6% in the population under study during this time frame. The logistic regression model
was found to have an AUC of 0.89 (95% CI 0.84 ‐ 0.94) when including four features: exposure history, temperature, WBC, and chest radiograph result. Random forest method resulted in AUC of 0.86 (95% CI 0.79 ‐ 0.92) and gradient boosting had an AUC of 0.85
(95% CI 0.79‐0.91). With a consistently held negative predictive value, the logistic regression model had a positive predictive value of 0.29 (0.2‐0.39) compared to 0.2 (0.14‐0.28) for random forest and 0.22 (0.15 – 0.3) for the gradient boosted method. |
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Metelmann, IB, Busemann, et al |
Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen |
Healthcare Response | Réponse des soins de santé |
The present study investigates postponed elective surgery and its impact on the medical condition of patients in two
high-volume departments of general, visceral, thoracic, transplant and vascular surgery. In the Leipzig and Greifswald University Hospitals 89 and 92 elective surgeries were postponed, respectively. No patient needed an extension of surgical procedure when
eventually operated. One patient with extensive obesity died early during the suspension period due to cardiac complications. Four patients needed emergency admission to hospital one of whom required urgent surgery. In neither of the two surgical departments
did a patient acquire a nosocomial infection with COVID-19. |
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Positive rates predict death rates of Covid-19 locally
and worldwide 13 days ahead |
Mimkes, Juergen, Janssen, et al |
medRxiv |
Epidemiology| Épidémiologie |
By interpreting the portion of positive tests as a positive rate, we find the positive rate and the numbers of deceased
to run parallel with an offset of about 13 days. This has been observed worldwide in ten other countries and locally in Germany and North Rhine-Westphalia. The daily positive ratio, which is reported by state health authorities, allows to estimate the number
of deaths (and seriously ill people) about 13 days ahead. This gives local hospitals more time for detailed planning. |
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On the use of corticosteroids for critically ill patients with SARS-CoV-2 interstitial
pneumonia |
Mingoia, A, Lejeune, et al |
Revue medicale de Liege |
Clinical data| Données cliniques |
The health crisis caused by SARS-Cov2 continues to question the scientific community on an effective treatment to combat
the disease. To do this, understanding the pathophysiology is a key element. Although the use of corticosteroids is debated, recent publications on pathogenesis and histologic pattern allow us to consider their use on a different way. Through these two case
reports, it seemed interesting to take stock of the most recent data in the literature and on the potential interest of the corticotherapy in specific critically ill patient's cases. |
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A COVID-19 Model for Local Authorities of the United
Kingdom |
Mishra, Swapnil, Scott, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We propose a new framework to model the COVID-19 epidemic of the United Kingdom at the level of local authorities.
The model fits within a general framework for semi-mechanistic Bayesian models of the epidemic, with some important innovations: we model the proportion of infections that result in reported deaths and cases as random variables. The model is tailored and designed
to be updated daily based on publicly available data. |
|
Moges, Tamirat, Abebe, et al |
medRxiv |
Public Health response| Interventions de santé publique |
This study was to determine the impact of the pandemic on the care-seeking behavior of patients with chronic health
conditions at Tikur Anbessa Specialized Hospital in Addis Ababa. A cross-sectional hospital-based survey conducted between May and July 2020 on patients whose appointment was between March to June 2020. A sample of 750 patients was approached using phone
calls and data collection was done using a pretested questionnaire. A total of 644 patients with a median age of 25 years, and an M: F ratio of 1:1.01 was described with a response rate of 86%.In the multivariable logistic regression analysis, patients above
60 years old were more likely to miss follow-up (OR-23.28 (9.32-58.15), P<001). Patients who reported fear of COVID-19 at the hospital were 19 times more likely to miss follow-up (adjusted OR=19.32, 95% CI:10.73-34.79, P<0.001), while patients who reported
transportation problems were 6.5 times more likely to miss follow-up (adjusted OR=6.11, 95% CI:3.06-12.17, P<0.001). |
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An asthmatic pregnant woman with COVID-19: A case report study |
Motlagh, AJ, Esmaelzadeh Saeieh, et al |
Respiratory Medicine Case Reports |
Clinical data| Données cliniques |
We present an Asthmatic pregnant woman who infected with SARS-CoV-2 admitted to two hospitals in Iran. The patient's
symptoms were dry coughs, dyspnea, and inability to speak, numbness, and fatigue. The initial examination indicated a body temperature of 37.9 °C, oxygen saturation (SPO2) 91%, partial pressure of oxygen (Pao2) was 25 mm Hg, respiratory rate (RR) of 20 breaths/minute
(b/m), blood pressure of 100/60 mmHg, and pulse of 80 bpm (beat/minute) and fetal heart rate (FHR) = 167/min. The pregnancy terminated by Caesarean Section (C/S) due to fetal tachycardia, a healthy baby with normal range. Our case had leukopenia and also revealed,
elevated C-reactive protein and erythrocyte sedimentation rate. Our case received supportive care and antibiotic & antiviral therapy and was discharged within 8 days with a good general condition. |
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Use of telemedicine in obstetrics and gynaecology in zimbabwe during a
lockdown period |
Moyo, J, Madziyire, et al |
Pan African Medical Journal |
Healthcare Response | Réponse des soins de santé |
We sought to determine the effectiveness and acceptability of telemedicine in Obstetrics and Gynaecology. of 109 women
who used telemedicine 67consented. The average age was 31 years, had university or tertiary college education and were urban dwellers. Forty-nine (73.1%) cases were Gynaecological consults and 51 (76.1%) were elective cases. Twenty (29.9%) and fourteen (20.8%)
cases needed elective and urgent hospital referral respectively. A diagnosis was made in 33(49.3%) of the cases from the available information during the consult. Thirty-five (52.2%) cases had recovered whilst 27(40.3%) cases were still waiting further assessments
at the end of the follow up. The patients were satisfied with the service in 94% of the cases. |
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Predictors of laboratory-positive COVID-19 in children and teenagers |
Murillo-Zamora, E, Aguilar-Sollano, et al |
Public health |
Epidemiology| Épidémiologie |
The aim of the study was to identify factors predicting laboratory-positive coronavirus disease 2019 (COVID-19) in
pediatric patients with acute respiratory symptoms. We conducted a cross-sectional analysis of a prospective cohort study. Data from 1849 individuals were analyzed. COVID-19 was confirmed (reverse transcription-quantitative polymerase chain reaction) in 15.9%
of patients. Increasing age, personal history of obesity, and household contact with a case were found to be associated, in the multiple regression model, with increased odds of a positive test result. Young patients residing in areas with higher population
sizes, as well as those with severe respiratory symptoms, were less likely to be laboratory confirmed. |
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Murti, Michelle, Achonu, et al |
medRxiv |
Epidemiology| Épidémiologie Transmission |
To understand industry sectors impacted by workplace outbreaks in the first wave of the pandemic within Ontario, and
the additional burden of illness through household transmission, we analyzed public health declared workplace outbreaks between January 21 to June 30, 2020, and their associated cases from January 21 to July 28. There were 199 outbreaks with 1245 cases, and
68% of outbreaks and 80% of cases belonged to i) Manufacturing, ii) Agriculture, Forestry, Fishing, Hunting, iii) Transportation and Warehousing. There were 608 household cases associated with 339 (31%) outbreak cases, increasing the burden of illness by 56%. |
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Nachtigall, I, Lenga, et al |
Clin Microbiol Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We describe the clinical course and examine factors associated with outcomes among patients hospitalized with COVID-19
in Germany. We included 1904 patients with a median age of 73 years, 48.5% (924/1904) of whom were female. The mortality rate was 17% (317/1835; 95% confidence interval (95%CI) 16–19), the rate of admission to the intensive care unit (ICU) was 21% (399/1860;
95%CI 20–23), and the rate of invasive mechanical ventilation was 14% (250/1850: 95%CI 12–15). |
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A dramatic rise in serum ACE2 activity in a critically ill COVID-19 patient |
Nagy, B, Fejes, et al |
Int J Infect Dis |
Clinical data| Données cliniques |
Here we present a case of a critically ill COVID-19 patient with acute respiratory distress syndrome where circulating
ACE2 was first measured to monitor disease prognosis. ACE2 activity increased about 40-fold over the normal range and showed a distinct time course compared to 2-3-fold higher levels of endothelium biomarkers. |
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Nanda, Piyush, Ghosh, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We developed an integrated genome-scale metabolic model of normal human bronchial epithelial cells (NHBE) infected
with SARS Cov2 using gene-expression and macromolecular make-up of the virus. The reconstructed model predicts growth rates of the virus in high agreement with the experimental measured values. Furthermore, we report a method for conducting genome-scale differential
flux analysis (GS-DFA) in context-specific metabolic models. |
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Newall, AT, Leong, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie |
The aim of this study was to estimate delay-adjusted case fatality rates (CFRs) for COVID-19 in South Korea, and evaluate
how these estimates have evolved over time throughout the epidemic. The overall estimated delay-adjusted CFR was 2.39% (3.05% for males and 1.92% for females). Within each age strata where deaths were reported, males were found to have significantly higher
CFRs than females. |
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Niedzwiedz, ClaireL, Benzeval, et al |
medRxiv |
Long-Term Sequelae |
|
We explored the relationship between reporting probable COVID-19 symptoms in April 2020 and psychological distress
(measured using the General Health Questionnaire) one, two and three months later. Data were taken from the UK Household Longitudinal Study, a nationally representative household panel survey of UK adults. Elevated levels of psychological distress were found
up to three months after probable COVID-19, compared to participants with no likely infection. Associations were stronger among younger age groups and men. |
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Path-dependent course of epidemic: are two phases of quarantine better than one? |
Nimmagadda, Varun, Kogan, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
We consider an SIR model on a network and follow the disease dynamics, modeling the phases of quarantine by changing
the node degree distribution. We show that the system reaches different steady states based on the history: the outcome of the epidemic is path-dependent despite the same final node degree distribution. The results indicate that two-phase route to the final
node degree distribution (a strict phase followed by a soft phase) are always better than one phase (the same soft one) unless all the individuals have the same number of connections at the end. |
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Niu, W, Wu, et al |
Evidence-based Complementary and Alternative Medicine |
Therapeutics| Thérapeutique |
The aims of this study were to identify the active components of “Three formulas and three medicines” that can be used
to treat COVID-19, determine their mechanism of action via angiotensin-converting enzyme 2 (ACE2) by integrating network pharmacological approaches, and confirm the most effective components for COVID-19 treatment or prevention. Traditional Chinese medicine
(TCM) plays a pivotal role in the prevention and treatment of COVID-19. Quercetin, glabridin, and gallic acid, the active components of recommended TCM formulas and medicines, can inhibit COVID-19 by downregulating ACE2. |
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Nkansah, C, Serwaa, et al |
Pan African Medical Journal |
Healthcare Response | Réponse des soins de santé |
This study assessed health workers’ knowledge, practice, and preparedness on the current pandemic in three Ghanaian
hospitals. The overall knowledge, practice and willingness of healthcare workers to handle COVID-19 were encouraging; however, this study still elucidates the knowledge gap of the professionals on the pandemic. |
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Northstone, K, Smith, et al |
Wellcome Open Research |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a prospective population-based cohort study which recruited
pregnant women in 1990-1992 and has followed these women, their partners and their offspring ever since. The online questionnaire was deployed across the parent and offspring generations between the 26th May and 5th July 2020. 6482 participants completed the
questionnaire (2639 original mothers, 1039 original fathers/partners, 2711 offspring (mean age ~28 years) and 93 partners of offspring). A positive COVID-19 test was reported by 36 (0.6%) participants (12 G0 and 24 G1), 91 (1.4%; 35 G0 and 56 G1) reported
that they had been told by a doctor they likely had COVID-19 and 838 (13%; 422 G0 and 416 G1) suspected that they have had COVID-19. |
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Noureddine, O, Issaoui, et al |
J King Saud Univ Sci |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In the present work, the chloroquine and the chloroquine phosphate molecules have been proposed as potential antiviral
for the treatment of COVID-19 diseases combining DFT and molecular docking calculations. As results, we found a good agreement between the theoretical and the experimental geometrical parameters (bond lengths and bond angles). Docking calculations were carried
out to determine the pharmaceutical activities of the chloroquine derivatives against coronavirus diseases. The choice of these ligands was based on their antiviral activities. |
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Novelli, L, Raimondi, et al |
Panminerva Med |
Epidemiology| Épidémiologie |
The aim of this study was to investigate predictors of overall 28-day mortality at the peak of the Italian outbreak.
Retrospective observational study of all Covid-19 patients admitted to the main hospital of Bergamo, from February 23 to March, 14, 2020. 508 patients were hospitalized , predominantly male (72.4%), mean age of 66±15 years; 49.2% were older than 70 years.
At the peak of the outbreak, with a probable high infectious dose and viral load, older age, the severity of respiratory failure and renal impairment at presentation, but not comorbidities, are predictors of 28-day mortality in Covid-19. |
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Nunan, J, Clarke, et al |
Acute medicine |
Healthcare Response | Réponse des soins de santé |
Safe triage and follow up systems are required to manage this unprecedented demand. We designed a pathway for the triage
and assessment of patients based on their resting oxygen saturations and response to a 30 metre rapid walking test. During the first wave of COVID-19 we entered 273 onto the pathway for Virtual Ward follow up. Of these, 31 patients were readmitted to hospital,
two were admitted to Intensive Care and one patient died. It is safe, feasible and cost effective to set up a triage system with remote oximetry monitoring for patients with COVID-19 and overwhelmingly patients find it a positive experience. |
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Nunes-Santos, C, Kuehn, et al |
J Clin Immunol |
Therapeutics| Thérapeutique |
We assessed the in vitro activity of the FDA-approved α-glucosidase inhibitor miglustat against SARS-CoV-2. Our work
shows that despite clear N-glycan alteration in the presence of miglustat, the functions of the Covid-19-related glycoproteins studied were not affected, making it unlikely that miglustat can change the natural course of the disease. |
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Omrani, AS, Pathan, et al |
EClinicalMedicine |
Therapeutics| Thérapeutique RCT |
The Qatar Prospective RCT of Expediting Coronavirus Tapering (Q-PROTECT) aimed to assess virologic cure rates of HC±AZ
in cases of low-acuity Covid-19. The study enrolled 456 participants (152 in each of three groups: HC+AZ, HC, placebo) between 13 April and 1 August 2020. HC+AZ, HC, and placebo groups had 6 (3·9%), 7 (4·6%), and 9 (5·9%) participants go off study medications
before completing the medication course (p = 0·716). Day six ITT analysis found no difference (p = 0·821) in groups’ proportions achieving virologic cure; and day 14 assessment also showed no association (p = 0·072) between study group and viral cure. HC±AZ
does not facilitate virologic cure in patients with mild or asymptomatic Covid-19. |
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Paglia, S, Nattino, et al |
Acad Emerg Med |
Healthcare Response | Réponse des soins de santé |
We studied the prognostic value of the Quick Walk Test (QWT) for patients suspected of COVID-19 during
an outbreak, focusing on the need for invasive mechanical ventilation (MV) within 15 days from the first ED access as outcome. As median times from illness onset to clinical deterioration of 8.44 or 14.55 days have been reported, a follow up of 15 days was
chosen to capture most of the severe clinical deteriorations, while excluding events that were not directly related to the severity of the COVID-19 infection. |
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Multi-chain Fudan-CCDC model for COVID-19—a revisit to Singapore’s case |
Pan, H, Shao, et al |
Quantitative Biology |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We propose the multi-chain Fudan-CCDC model based on the original single-chain model in [Shao et al. 2020] to describe
the evolution of COVID-19 in Singapore. Multi-chains can be considered as the superposition of several single chains with different characteristics. We identify the parameters of models by minimizing the penalty function. The multi-chain Fudan-CCDC model provides
an effective way to early detect the appearance of imported infectors and super spreaders and forecast a second outbreak. It can also explain the data from those countries where the single-chain model shows deviation from the data. |
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Panayiotou, G, Panteli, et al |
Journal of Contextual Behavioral Science |
Mental Health |
|
This study examined how the quality of life of college students was affected during the COVID-19 crisis and lockdown
in Cyprus, with a two-wave measurement design, which included a pre-pandemic baseline. The effect of emotion regulation styles on quality of life change was examined. Unexpectedly, difficulty identifying feelings predicted better sustained quality of life,
pointing to the potential usefulness of alternative and flexible emotion regulation strategies in coping with such crises. |
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Paranjpe, I, Russak, et al |
BMJ Open |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to compare clinical characteristic of patients with COVID-19 who had in-hospital mortality with those who
were discharged alive. Demographic, clinical and outcomes data for patients admitted to five Mount Sinai Health System hospitals with confirmed COVID-19 between 27 February and 2 April 2020 were identified through institutional electronic health records. In
our cohort of hospitalised patients, requirement of intensive care and mortality were high. Patients who died typically had more pre-existing conditions and greater perturbations in inflammatory markers as compared with those who were discharged. |
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Spatially resolved simulations of the spread of COVID-19
in European countries |
Parisi, Andrea, Brand, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
We explore the spatial and temporal spread of the novel SARS-CoV-2 virus under containment measures in three European
countries based on fits to data of the early outbreak. Using data from Spain and Italy, we estimate an age dependent infection fatality ratio for SARS-CoV-2, as well as risks of hospitalization and intensive care admission. We use them in a model that simulates
the dynamics of the virus using an age structured, spatially detailed agent based approach, that explicitly incorporates governamental interventions, changes in mobility and contact patterns occurred during the COVID-19 outbreak in each country. |
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Pastor-Barriuso, R, Pérez-Gómez, et al |
Bmj |
Epidemiology| Épidémiologie Immunology | Immunologie |
We aim to estimate the infection fatality risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based
on deaths with confirmed coronavirus disease 2019 (covid-19) and excess deaths from all causes. The main outcome measure was overall, and age and sex specific, infection fatality risk for SARS-CoV-2 in the community dwelling Spanish population. The overall
infection fatality risk was 0.8% (19 228 of 2.3 million infected individuals, 95% confidence interval 0.8% to 0.9%) for confirmed covid-19 deaths. The increase in SARS-CoV-2 infection fatality risk after age 50 appeared to be more noticeable in men than in
women. Based on the results of this study, fatality from covid-19 was greater than that reported for other common respiratory diseases, such as seasonal influenza. |
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Cost Estimates Related to COVID-19 Treatment in Indonesia: What Should be Concerned? |
Patria Jati, S, Budiyono, et al |
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Healthcare Response | Réponse des soins de santé Economics | Économie |
Identify the estimated cost for treating the Covid-19 patients in Indonesia. Estimate if patients were treated in
ICU for 8 days and non ICU for 7 days, and the rest of inpatients according to INACBs, so the cost of COVID-19 treatment for 14 - 28 days estimated at 75.7-77.3 million rupiah/patient. Whereas if the patient treated in ICU for 14 days and non ICU for 14 days,
the rest of inpatient according to INACBs, the cost for COVID-19 treatment estimated at 130.4- 133.2 million rupiah/patient. The COVID-19 treatment is quite expensive and can be a burden for the Government of Indonesia's budget. I |
|
Peng, X, Zhou, et al |
New Journal of Physics |
Coronavirology| Coronavirologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Propose a novel NIR SPR biosensor for monitoring SARS-CoV-2 and S glycoprotein. Linear detection range for S glycoprotein
and SARS-CoV-2 specimens is ~0–301.67 nM and ~0–67.8762 nM. The study offers an alternative strategy for rapidly performing novel coronavirus diagnosis in clinical applications. |
|
|
Penuliar, MichaelS, Clark, et al |
medRxiv |
Epidemiology| Épidémiologie |
Investigates the relationship between COVID-19 case growth, university-county rurality, and time at the beginning of
the Fall 2020 academic semester. Findings showed that small metro and non-metro counties with universities had a dramatic infection spike near the beginning of the semester and infection growth remained significantly higher than their large and medium metro
counterparts for the duration of the study. |
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Universities and COVID-19 Growth at the Start of
the 2020 Academic Year |
Penuliar, MichaelS, Clark, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Work investigates how the growth of COVID-19 compares in areas with large universities against those without by applying
a SIR model. Results showed markedly increase case growth in counties with large universities at the start of the fall 2020 semester. |
|
Pieruzzini, Rosalinda, Ayala-Grosso, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Smell and taste disorders are frequent symptoms of SARS-CoV-2 infection, but not a significant predictor of the disease,
as compared to the molecular RT-PCR test. |
|
|
Pinto, Ana Jessica, Goessler, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Investigate the possible associations between physical activity levels and clinical outcomes among hospitalized patients
with severe COVID-19. Linear regression models showed that physical activity indexes were not associated with hospital length of stay mortality, admission to ICU and mechanical ventilation requirement. |
|
|
SARS-CoV-2 Transmission in an Urban Community: The Role of Children and Household Contacts |
Pitman-Hunt, C, Leja, et al |
J Pediatric Infect Dis Soc |
Epidemiology| Épidémiologie |
A single center US retrospective study of infection patterns among household sick contacts of children with confirmed
Severe Acute Respiratory Syndrome – Coronavirus 2 (SARS-CoV-2) infection in an urban setting. A household sick contact (HHSC) was identified in fewer than half (42%) of patients and no child-to-adult transmission was identified. |
|
PMC7693853; Expression and co-expression analyses of TMPRSS2, a key element in
COVID-19 |
Piva, F, Sabanovic, et al |
Eur J Clin Microbiol Infect Dis |
Epidemiology| Épidémiologie |
Analyzed TMPRSS2 expression data in the lung correlating them with age, sex, diabetes, smoking habits, exposure to
pollutant and other stimuli, in order to highlight which factors might alter TMPRSS2 expression, and thus impact the susceptibility to infection and COVID-19 prognosis. Report TMPRSS2 polymorphisms affecting its expression and suggest some ethnic groups more
prone to COVID-19. |
|
Priya, P, Shanker, et al |
Infect Genet Evol |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Bioinformatics study identify coevolving amino acids in spike glycoprotein that increase infectivity of SARS-CoV-2 |
|
|
Halting a SARS-CoV-2 outbreak in a US Veterans Affairs nursing home |
Psevdos, G, Papamanoli, et al |
American Journal of Infection Control |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Creating a geographic “COVID” unit, implementing universal screening tests of residents and staff, and strictly enforcing
infection control measures were all important to contain a COVID-19 outbreak in a Veterans nursing home. |
|
Psychological impact of the COVID-19 pandemic on health care workers |
Qasem Surrati, AM, Asad Mansuri, et al |
Journal of Taibah University Medical Sciences |
Mental Health |
|
Assess the magnitude of depression, anxiety, and stress among health care workers by the coronavirus disease (COVID-19)
in Almadinah Almunawwarah, KSA. Study found a high prevalence of anxiety, depression, and moderate stress among healthcare workers, regardless of their job specifications. The associated risk factors for anxiety and depression included inadequate training
for infection control, and pre-existing stress-provoking medical conditions. |
|
Rajkumar, RP |
JMIR Public Health Surveill |
Epidemiology| Épidémiologie |
Examine the statistical associations between the statewise prevalence, mortality rate, and case fatality rate of COVID-19
in 24 regions in India (23 states and Delhi). COVID-19 prevalence was negatively associated with male-to-female sex ratio (defined as the number of females per 1000 male population) and positively associated with the presence of an international airport in
a particular state. The crude mortality rate for COVID-19 was negatively associated with sex ratio and the statewise burden of diarrheal disease, and positively associated with the statewise burden of ischemic heart disease. |
|
|
Ray, Yogiraj, Paul, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique
RCT |
Assess the pathogen and host-intrinsic factors influencing clinical and immunological benefits of passive immunization
using convalescent plasma therapy (CPT), in addition to standard of care (SOC) therapy in severe COVID-19 patients, as compared to patients only on SOC therapy. While across all age-groups no statistically significant clinical benefit was registered for patients
in the CPT arm, significant immediate mitigation of hypoxia, reduction in hospital stay as well as survival benefit was recorded in severe COVID-19 patients with ARDS aged less than 67 years receiving convalescent plasma therapy. |
|
|
Correlates of Mental Health Symptoms Among US Adults During COVID-19, March–April
2020 |
Reading Turchioe, M, Grossman, et al |
Public health reports |
Mental Health |
|
Examine mental health symptoms among US adults in an early stage of the COVID-19 pandemic. Participants reported high
levels of anxiety (mean [SD], 57.2 [9.3]) and depression (mean [SD], 54.2 [9.5]). Levels of anger, anxiety, cognitive function, depression, and fatigue were significantly higher among the Millennial Generation and Generation X (vs Baby Boomers), those with
not enough or enough (vs more than enough) financial resources, females vs males), those with self-reported disability (vs no self-reported disability), and those with inadequate (vs adequate) health literacy. In adjusted models, being in Generation X and
the Millennial Generation (vs Baby Boomer), having not enough or enough vs more than enough) financial resources, and having inadequate (vs adequate) health literacy were most strongly correlated with worse mental health symptoms. |
|
Rebecchi, F, Arolfo, et al |
Dis Esophagus |
Healthcare Response | Réponse des soins de santé |
The Italian Society for Study of Esophageal Diseases (SISME) conducted a national survey to evaluate changes in esophageal
cancer management in a region severely struck by COVID-19 pandemic. |
|
|
Recalde, Martina, Pistillo, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Investigate associations between body mass index (BMI) and risk of COVID-19 diagnosis, hospitalisation with COVID-19,
and COVID-19-related death, accounting for potential effect modification by age and sex. There is a monotonic association between BMI and COVID-19 infection and hospitalisation risks, but a J-shaped one with mortality. |
|
|
PMC7455546; Predicting the second wave of COVID-19 in Washtenaw County, MI |
Renardy, M, Eisenberg, et al |
J Theor Biol |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Through simulations and sensitivity analyses, we explore mechanisms driving the magnitude and timing of a second wave
of infections upon re-opening. Model find that the most significant factors that impact a second wave are workplace and casual contacts and protective measures taken by infected individuals who have sought care. |
|
Renelus, BD, Khoury, et al |
Dig Liver Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A mortality analysis of COVID-19 patients hospitalized at a New York City (NYC) hospital (n=231) at the height of the
pandemic to determine whether or not the presence of gastrointestinal symptoms was associated with patient survival to discharge. The presence of GI symptoms was associated with reduced in-hospital mortality. |
|
|
SARS-CoV-2 Seroprevalence among First Responders
in the District of Columbia, May – July 2020 |
Reuben, Jacqueline, Sherman, et al |
medRxiv |
Epidemiology| Épidémiologie Immunology | Immunologie |
A serologic survey to estimate SARS-CoV-2 seroprevalence and assess risk factors and occupational exposures among a
convenience sample of first responders in DC. Among first responders tested, 3.5% (n = 11) had anti-SARS-CoV-2 antibodies. Seropositivity varied by occupation, with 4.8% (3/62) of firefighters; 3.6% (8/220) of police officers; and no paramedics (0/10) or administration
and support staff (0/18) testing positive. Type and consistency of personal protective equipment (PPE) use also varied: all paramedics (n=10) reported wearing a N95 respirator all or most of the time, compared to 83.3% of firefighters, 38.8% of police officers,
and 23.5% of administration and support staff (p<0.001). |
|
Riad, A, Kassem, et al |
Spec Care Dentist |
Clinical data| Données cliniques |
This study reports the demographic, clinical and laboratory characteristics of eighteen patients with confirmed COVID‐19
without any relevant medical history, who experienced new‐onset halitosis during their course of infection. Two patients (11.1%) had persistent fever, a further two patients (11.1%) had anosmia, one (5.6%) had ageusia, and one (5.6%) presented with a dry cough.
All patients had physiological halitosis. A one‐way within‐subjects ANOVA test yielded a significant decrease in halitosis intensity over time in the vast majority of the patients who used mouthwash. |
|
|
Rieder, M, Wirth, et al |
J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
The goal of this prospective single-center study was to identify distinct protein expression in serum of patients with
COVID-19 versus patients presenting with comparable symptoms and disease severity but tested negative for SARS-CoV-2. Interleukin-6 abundance was similar in SARS-CoV-2 positive patients (n = 24) compared to SARS-CoV-2 negative control (n = 61). In contrast,
we observed a specific upregulation of the immunomodulatory protein progranulin (GRN). High GRN abundance was associated with adverse outcomes and increased expression of interleukin-6 in COVID-19. |
|
|
PMC7688433; Ct value is not enough to discriminate patients harbouring infective
virus |
Romero-Gómez, MP, Gómez-Sebastian, et al |
J Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated the infectivity of clinical samples obtained from patients with SARS-CoV-2, comparing the results obtained
by RT-PCR with the growth capacity of the virus in vitro. A total of 72 specimens of NP from 66 patients were analysed in this study. Medical records for these patients regarding epidemiological and clinical data were retrospectively reviewed. We found a
significant difference between Ct of culturable and nonculturable samples. The highest Ct value in samples with positive cultures was found to be 36.08, 37.73 and 37.41 for the ORF1ab, N and S genes in a sample taken one day after symptom onset, while positive
cultures were typically associated with low Ct values. The maximum time after the onset of symptoms in which the virus was isolated was 12 days. Freeze-thaw cycle did not significantly affect the positive culture rate. |
|
Saez-de-Ocariz, M, Gámez-González, et al |
Pediatr Int |
Clinical data| Données cliniques |
This study presents a case of Multisystemic inflammatory syndrome in a child associated with SARS-CoV-2 with a Kawasaki
disease-like presentation. A previously healthy 10-year-old male presented to the emergency department with 6 days of fever. He had had abdominal pain on the first 2 days and presented a morbilliform rash, palmar and plantar erythema associated with hands
and feet edema, odynophagia and bilateral nonexudative conjunctivitis. His father had been diagnosed with SARS-CoV-2 infection 4 weeks prior. Nasopharingeal PCR for SARS-CoV-2 was negative and positive IgG for SARS-CoV-2. The patient was discharged after
10 days without further complications. |
|
|
Saha, MM, Das, et al |
Indian Journal of Biochemistry and Biophysics |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
In our prospective observational study total of 56 pregnant women admitted in the isolation ward were included. All
women presented with common symptoms like fever, tiredness, headache, sore throat, and cough. Three women were diagnosed SARS-CoV-2/COVID-19 positive by RT-PCR examination of the nasopharyngeal swab. All three neonates tested negative for SARS-CoV-2 infection.
The three mothers also recovered with routine care and returned home after 7 days with advice for a safe home for further 7 days. There is no increased risk of severe disease during pregnancy. Neonates are mostly protected from disease transmission due to
immune modulation during pregnancy. |
|
|
Saini, N, Saini, et al |
Indian Journal of Biochemistry and Biophysics |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We retrospectively analysed the Gamma glutamyl-transferase (GGT) levels of 476 admitted patients with confirmed COVID-19
in a tertiary care centre in Chandigarh. Out of the total 476 COVID-19 patients studied, 35% had elevated GGT levels. ICU care was required for 51.19% (P <0.0001) of these patients and their hospital stay was of longer duration as compared to the patients
with normal GGT levels. The incidence of GGT elevation was found to be more pronounced in males and elderly patients. |
|
|
Low dose radiotherapy in the management of covid19 pneumonia (LOWRAD-Cov19).
Preliminary report |
Sanmamed, N, Alcantara, et al |
Int J Radiat Oncol Biol Phys |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Low-Dose Radiation (LD-RT) has demonstrated to have anti-inflamatory effect and, preliminary results suggest it is
feasible to treat COVID-19 pneumonia. We conducted a prospective single arm phase I-II clinical trial enrolling patients ≥ 50 years-old COVID-19 positive. Nine patients were included. Our preliminary results show that LD-RT was a feasible and well-tolerated
treatment, with potential clinical improvement. |
|
Saponaro, G, Gasparini, et al |
Minerva Stomatol |
Healthcare Response | Réponse des soins de santé |
We aimed to analyze the incidence and type of facial traumas referred to our tertiary care hospital during the months
of Italy lockdown due to SARS-CoV-2 spread compared with those during the same months of 2019 to determine eventual variations in the incidence, type and causes of trauma. During the 2 months of COVID-19-related lockdown, a dramatic decrease in facial trauma
patients was observed at our tertiary care hospital with a shift toward older age ranges. Regarding the causes of trauma, the largest percentage reduction was found in road, sports and work accidents; this percentage reduction was not found in aggressions. |
|
|
Impacts of face coverings on communication: an indirect impact of COVID-19 |
Saunders, GH, Jackson, et al |
Int J Audiol |
Public Health response| Interventions de santé publique |
The objective of this online survey was to understand the impact of face coverings on hearing and communication in
the context of COVID-19. 460 members of the general public were recruited via snowball sampling. People with hearing loss were intentionally oversampled to more thoroughly assess the effect of face coverings in this group. Participants reported that face coverings
negatively impacted hearing, understanding, engagement, and feelings of connection with the speaker. Impacts were greatest when communicating in medical situations. People with hearing loss were significantly more impacted than those without hearing loss. |
|
Impact of the COVID-19 pandemic on developmental
care practices for infants born preterm |
Scala, Melissa, Marchman, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to assess the impact of the COVID-19 pandemic on rates of hospital visitation and rates
and durations of developmental care practices for infants born preterm. Results indicated that families of infants in the 2020 cohort visited less frequently (47% of available days) than those in the 2019 cohort (97%; p=0.001). Infants received developmental
care activities less frequently in the 2020 cohort (3.51 vs. 4.72 activities per day; p=0.04), with a lower number of minutes per day (99.91 vs. 145.14; p=0.04) and a shorter duration per instance. |
|
Schimit, PHT |
Computer methods and programs in biomedicine |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
By tuning the proposed SEIR model to fit Brazil's initial COVID-19 data, the objectives of the paper are to analyze
the impact of the social isolation features on the population dynamics; simulate the number of deaths due to COVID-19 and due to the lack of healthcare infrastructure. Results showed that efforts in the social isolation campaign must be concentrated both on
the isolation percentage and campaign duration to delay the healthcare system failure. For the hospital situation in Brazil at the beginning of the pandemic outbreak, a rate of 200 purchases per day of intensive care units and mechanical ventilators is the
minimum rate to prevent the collapse of the healthcare system. |
|
|
Schulze, Hansjoerg, Hoffmann, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To provide better understanding of mild SARS-CoV-2 infections and to improve information for potentially infected individuals,
we performed a detailed analysis of self-reported symptoms of SARS-CoV-2 positive and SARS-CoV-2 negative individuals. The symptoms reported most frequently by SARS-CoV-2 infected individuals were tiredness, loss of appetite, impairment of smell or taste and
dry cough. The symptoms with the highest odds ratios between SARS-CoV-2 positive and negative individuals were loss of appetite and impairment of smell or taste. A combination of symptoms can provide a good estimate of the probability of SARS-CoV-2 infection. |
|
|
Schwank, SE, Chung, et al |
BMJ Open |
RCT |
INTRODUCTION: Mental health disorders are common during pregnancy and the postnatal period and can have serious adverse
effects on women and their children. The consequences for global mental health due to COVID-19 are likely to be significant and may have a long-term impact on the global burden of disease. Besides physical vulnerability, pregnant women are at increased risk
of mental health problems such as anxiety, depression and post-traumatic stress disorder due to the consequences of social distancing. It can result in altered healthcare routines, less support from the family and friends, and in some cases, partners not being
allowed to be present during prenatal visits, labour and delivery. Higher than expected, rates of perinatal anxiety and depression have been already reported during the pandemic. Pregnant women may also feel insecure and worried about the effects of COVID-19
on their unborn child if they get infected during pregnancy. Today, young urban women are used to using internet services frequently and efficiently. Therefore, providing mental health support to pregnant women via internet may be effective in ameliorating
their anxiety/depression, reducing the risk of serious mental health disorders, and lead to improved maternal and perinatal outcomes. OVERARCHING AIM: Our aim is to explore the effectiveness of a web-based psychosocial peer-to-peer support intervention in
reducing the risk and severity of perinatal mental health disorders and preventing adverse pregnancy outcomes among pregnant women living in metropolitan urban settings. METHODS AND ANALYSIS: We plan to conduct a multicentre prospective randomised controlled
trial, Mental health of Urban Mothers trial. Pregnant women living in large metropolitan cities will be recruited using internet-based application through non-profit organisations' websites. The women who consent will be randomised to receive a web-based peer-to-peer
support intervention or usual care. Data will be analysed to identify the effects of intervention on Edinburgh Postnatal Depression Score and Generalised Anxiety Disorder 7 scores as well as pregnancy outcomes. The impact of COVID-19 pandemic on maternal stress
will be assesed using Impact Event Scale-R. Any differences in outcomes between cities will be addressed in subgroup analyses. ETHICS AND DISSEMINATION: The study will be conducted according to the principles of Good Clinical Practice and will follow the ethical
principles of the Declaration of Helsinki. The study protocol has been approved by the ethical review board of Chinese University of Hong Kong (IRB number 2019-8170) and Shanghai Center for Women's and Children's Health (international review board (IRB) number
2020-F001-12). The results will be disseminated at national and international scientific conferences, published in peer-reviewed medical journals and spread to the public through social media, news outlets and podcasts. TRIAL REGISTRATION NUMBER: NCT04363177;
Trial sponsor Karolinska Institute, CLINTEC, Stockholm, Sweden. |
|
|
Sedaghat, Ahmad, Mosavi, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We propose a novel method that integrates an analytical solution of the infectious population using Weibull distribution
function into any SIR type models. The Weibull-SIRD method has easily fitted 4 set of COVID-19 biological data simultaneously. It is demonstrated that the Weibull-SIRD method predictions for susceptible, infected, recovered, and deceased populations from COVID-19
in Kuwait and UAE are superior compared with SIRD original ODE model. |
|
|
Sedaghat, Ahmad, Oloomi, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this study, several widely used models, including Richards, Gompertz, Logistic, Ratkowsky, and SIRD models, are
used to project dynamics of the COVID-19 pandemic in the future of Iran by fitting the present and the past clinical data. In Wave II, the reproduction number is reduced, indicating a lower transmission rate. Between 180,000 to 250,000 infected cases and a
death toll of between 6,000 to 65,000 cases are expected in Wave II of COVID-19 in Iran. |
|
|
SARS-CoV-2 infection hospitalization, severity, criticality,
and fatality rates |
Seedat, Shaheen, Chemaitelly, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to estimate the age-stratified and overall morbidity and mortality rates of SARS-CoV-2 infection based
on an analysis of the epidemic in Qatar. All outcomes showed very strong age dependence, with low values for those <50 years of age, but rapidly growing rates for those ≥50 years of age. The strong age dependence was particularly pronounced for infection
criticality rate and infection fatality rate. |
|
Seethy, AA, Singh, et al |
Placenta |
Coronavirology| Coronavirologie |
We explored in silico, the potential interactions between SARS-CoV-2 proteins and proteins involved in the key functions
of placenta. The entry receptors for SARS-CoV-2 – ACE2 and TMPRSS2 are expressed in placenta. SARS-CoV-2 can potentially interact with proteins having crucial roles in the placental function. Whether these potential interactions identified in silico have
effects on trophoblast functions in biological settings needs to be addressed by further in vitro and clinical studies. |
|
|
Shanshal, Mohammed, Ahmed, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
A cross-sectional observational study of 200 healthcare providers and 100 dermatologists (survey 1 and 2, respectively)
were conducted to determine the prevalence of occupational skin diseases among healthcare providers working amid the pandemic and to demonstrate the outbreaks impact on dermatology practice. Most healthcare providers (83%) reported hygiene-related hand dermatitis.
Telemedicine was provided by 73% of the dermatologists, and 89% reported minimal use of immunosuppressive drugs amid the pandemic. |
|
|
Nonlinear time series analysis of pathogenesis of covid-19 pandemic spread in saudi
arabia |
Sharma, SK, Bhardwaj, et al |
Computers, Materials and Continua |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This article discusses short-term forecasting of the novel Corona Virus (COVID-19) data for infected and recovered
cases using the ARIMA method for Saudi Arabia. COVID 19 data followed quadratic behavior, and in the long run, it spreads with a high peak. It is concluded that COVID-19 will follow secondary shock waves, and it is strongly advisable to maintain social distancing
with all safety measures as the pandemic situation is not in control. |
|
Shen, J |
Sci Rep |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper we design a recursive bifurcation model for analyzing COVID-19 virus spread in different countries. The
bifurcation facilitates recursive processing of infected population through linear least-squares fitting. In addition, a nonlinear least-squares fitting procedure is utilized to predict the future values of infected populations. Numerical results on the data
from two countries (South Korea and Germany) indicate the effectiveness of our approach, compared to a logistic growth model and a Richards model in the context of early forecast. |
|
|
Shen, M, Tong, et al |
Zhejiang da xue xue bao.Yi xue ban = Journal of Zhejiang University.Medical sciences |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to evaluate the application of three-in-one intelligent screening in outpatient pre-inspection
in children's hospital in China during the COVID-19 pandemic. The three-in-one intelligent pre-inspection mode took an average of (25.6±8.0) s for each child, which was significantly shorter than the traditional pre-inspection mode (74.8±36.4) s (t=13.182,
P 0.05) |
|
|
Clinical course of novel COVID-19 infection in pregnant women |
Shmakov, RG, Prikhodko, et al |
J Matern Fetal Neonatal Med |
Transmission Clinical data| Données cliniques Immunology | Immunologie |
The objective of this prospective observational study was to evaluate the clinical course of COVID-19 during pregnancy
and maternal and perinatal outcomes of this pregnancy. 66 women with PCR confirmed SARS-CoV-2 and their 42 neonates were included. Mostly, the manifestations of COVID-19 were mild. However, 9% of cases were severe, and could contribute to preterm delivery
or maternal morbidity. Main predictors of severe COVID-19 course in pregnant women were a decrease in the levels of erythrocytes and lymphocytes and increase in the levels of alanine aminotransferase and CRP. Elimination of the virus in pregnant women required
more time due to altered immunity. No evidence of vertical transmission during pregnancy and delivery was found. |
|
Shorfuzzaman, M, Hossain, et al |
Pattern Recognition |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Various AI functionalities such as pattern recognition and prediction can effectively be used to diagnose (recognize)
and predict coronavirus disease 2019 (COVID-19) infections and propose timely response (remedial action) to minimize the spread and impact of the virus. Motivated by this, an AI system based on deep meta learning has been proposed in this research to accelerate
analysis of chest X-ray (CXR) images in automatic detection of COVID-19 cases. We present a synergistic approach to integrate contrastive learning with a fine-tuned pre-trained ConvNet encoder to capture unbiased feature representations and leverage a Siamese
network for final classification of COVID-19 cases. We validate the effectiveness of our proposed model using two publicly available datasets comprising images from normal, COVID-19 and other pneumonia infected categories. Our model achieves 95.6% accuracy
and AUC of 0.97 in diagnosing COVID-19 from CXR images even with a limited number of training samples. © 2020 Elsevier Ltd |
|
|
Shukla, UrviB, Shukla, et al |
medRxiv |
Clinical data| Données cliniques |
Studied the associations of severity of disease and need for ICU treatment in COVID-19 patients. Average age was 41
years, 16% were <20 years of age, 55% were male, 50% were asymptomatic and 16% had at least one comorbidity. Using MoHFW India severity guidelines, 73% patients had mild, 6% moderate and 20% severe disease. Severity was associated with higher age, symptomatic
presentation, elevated neutrophil and reduced lymphocyte counts and elevated inflammatory markers. Seventy-seven patients needed ICU treatment: they were older (56 years), more symptomatic and had lower SpO2 and abnormal chest X-ray and deranged hematology
and biochemistry at admission. A model trained on the first 500 patients, using above variables predicted need for ICU treatment with sensitivity 80%, specificity 88% in subsequent 300 patients; exclusion of expensive laboratory tests did not affect accuracy. |
|
|
Siegler, JE, Zha, et al |
Stroke |
Healthcare Response | Réponse des soins de santé |
Evaluated whether the COVID-19 pandemic may have contributed to delays in acute stroke management at comprehensive
stroke centers. 1491 patients were admitted during the pre-COVID-19 period and 1464 were admitted during COVID-19, 15% of whom underwent intravenous thrombolysis. Patients treated during COVID-19 were at lower odds of receiving thrombolysis within 60 minutes
of arrival (odds ratio, 0.61), with a median delay in door-to-needle time of 4 minutes. The lower odds of achieving treatment in the Target: Stroke goal persisted after adjustment for all variables associated with earlier treatment (adjusted odds ratio, 0.55).
The delay in thrombolysis appeared driven by the longer delay from imaging to bolus (median, 29 minutes versus 22 minutes). There was no significant delay in door-to-groin puncture for patients who underwent thrombectomy (median, 83 minutes versus 90 minutes).
Delays in thrombolysis were observed in the months of June and July. |
|
|
Sileo, FG, Tramontano, et al |
Minerva Ginecol |
Clinical data| Données cliniques |
A pregnant woman was diagnosed with SARS-CoV2 at 35+5 weeks of gestation and managed conservatively at home. At transabdominal
ultrasound at 38+3 weeks, fetal bowel and gallbladder calcifications were noted. CMV and other infectious agents were ruled out; an iterative Caesarean Section was performed at 38+5 weeks without complications. Placenta resulted negative for SARS-CoV-2; the
umbilical cord blood sample was IgG positive and IgM negative as per maternal infection. The baby developed respiratory distress syndrome requiring endotracheal surfactant administration and nasal-CPAP for one day but nasopharyngeal swabs at birth and after
48 hours were SARS-Cov2 negative. Neonatal abdominal ultrasound showed normal liver, acalculous gallbladder with mild parietal thickening. The baby was discharged in good conditions. |
|
|
Simons, David, Perski, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Examined the association of smoking status with hospitalisation for COVID-19 compared with hospitalisation for other
respiratory virus infections a year previous and compared current smoking in cases with age- and sex-matched London prevalence. Patients hospitalised with COVID-19 had lower odds of being current smokers than patients admitted with other respiratory viruses
(ORadj=0.55). Odds were equivocal for former smokers (ORadj=1.08). Current smoking in cases was significantly lower than expected from London prevalence (9.4% vs. 12.9%). Smoking status recorded on the EHR deviated significantly from that recorded within the
medical notes (χ2(3)=226.7, p<.001). |
|
|
Rare Complication of Pneumomediastinum and Pneumopericardium in a Patient with COVID-19
Pneumonia |
Singh, A, Bass, et al |
Case Reports in Pulmonology |
Clinical data| Données cliniques |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently discovered coronavirus which has caused
a global outbreak of severe pneumonia with complications leading to hypoxic respiratory failure, acute respiratory distress syndrome (ARDS), cytokine storm, disseminated intravascular coagulation (DIC), and even gastrointestinal symptoms. While ground-glass
opacity (GGO) is a typical radiographic finding associated most frequently with COVID-19 pneumonia, other less commonly noted atypical radiographic lung features include isolated lobar or segmental consolidation without GGO, discrete small nodules (centrilobular,
"tree-in-bud"), lung cavitation, and smooth interlobular septal thickening with pleural effusion. Pneumomediastinum in COVID-19 patients has rarely been reported. A finding of pneumopericardium is unusual too. This report discusses the case of a young male
with COVID-19 pneumonia who was found to have both these features on computed tomographic (CT) scans of his chest on presentation. © 2020 Anshika Singh et al. |
|
Singh, H, Jakhar, et al |
Heliyon |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
Used various in – silico approaches to designed vaccine against COVID-19. To develop vaccine, we target S- protein,
expressed on the virus surface plays important role in COVID-19 infection. We identified 12 B-cell, 9 T-helper and 20 Cytotoxic T-cell epitope based on criteria of selection. The predicted epitopes were link simultaneously with GPGPG & AAY linkers. The β-defensin
was used as adjuvant, linked with selected epitope by using EAAAK linker. For vaccine construct justification we analysed its immunogenicity, allergenicity and physiochemical properties. Our study revealed that vaccine was non toxic, immunogenic and antigenic
in nature and covers 98.6% of world population, important for vaccine effectively. In- silico cloning was used to analyse its expression in vector. Molecular docking was performed to study the interaction of construct with TLR (TLR3, TLR4, and TLR9) molecules. |
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Multiple epitope-based vaccine prediction against SARS-CoV-2 spike glycoprotein |
Sirohi, PR, Gupta, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
Propose a detailed and comprehensive immunoinformatic approach that can be applied to the currently available coronavirus
protein data in the online server for vaccine candidate development. Identified the receptor binding domain (RBD) of structural spike protein (S1) as a potential target for immunity against COVID- 19 infection. Epitope prediction illustrated cytotoxic T-cell
epitopes, helper T-cell epitopes, and B-cell epitopes associated with the target protein. These were joined through specific linkers along with adjuvant beta-defensin located at the N-terminal to create a multi epitope subunit vaccine (MESV). The specificity
in the binding of the devised vaccine candidate to the TLR-3 immune cell receptor was evaluated via molecular docking interaction studies. Good docking score combined with robust interactions in the binding cavity certified the stringency of the engineered
vaccine. Molecular dynamics simulation data showed minimal variation of the root-mean square deviations (RMSDs) and root-mean-square fluctuations (RMSFs) which confirmed the interaction stability. |
|
A Novel Cell Therapy for COVID-19 and Potential Future
Pandemics: Virus Induced Lymphocytes (VIL) |
Sivapalan, Rohan, Liu, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Used a novel SARS-Cov-2-specific artificial antigen presenting cell (aAPC), coupled with a rapid expansion protocol
(REP) as practiced in tumor infiltrating lymphocytes (TIL) therapy, we generate an immune catalytic quantity of Virus Induced Lymphocytes (VIL). Using T cell receptor (TCR)-specific aAPCs carrying co-stimulatory molecules and major histocompatibility complex
(MHC) class-I immunodominant SARS-CoV-2 peptide-pentamer complexes, we expand virus-specific VIL derived from peripheral blood mononuclear cells (PBMC) of convalescent COVID-19 patients up to 1,000-fold. This is achieved in a clinically relevant 7-day vein-to-vein
time-course as a potential adoptive cell therapy (ACT) for COVID-19. Also evaluated this approach for other viral pathogens using Cytomegalovirus (CMV)-specific VIL from donors as a control. Rapidly expanded VIL are enriched in virus antigen-specificity and
show an activated, polyfunctional cytokine profile and T effector memory phenotype which may contribute to a robust immune response. Virus-specific T cells can also be delivered allogeneically via MHC-typing and patient human leukocyte antigen (HLA)-matching
to provide pragmatic treatment in a large-scale therapeutic setting. |
|
Sörgel, F, Malin, et al |
J Antimicrob Chemother |
Clinical data| Données cliniques |
Report on the pharmacokinetics of remdesivir and its metabolites and the treatment outcome in a patient on renal replacement
therapy without residual renal function suffering from severe COVID-19. A male patient in his mid seventies was admitted and diagnosed with COVID-19. Initially, he presented with typical pulmonary infiltrates and normal arterial blood gas results. However,
the patient’s clinical status deteriorated rapidly. Ten days after admission, the patient was transferred to the ICU with hypoxaemic lung failure requiring high-flow oxygen therapy. In this critical situation, we decided to apply remdesivir, while performing
extensive therapeutic drug monitoring of the prodrug and two metabolites for safety reasons. Overall, there were no signs of drug-related toxicity. By day 5 of remdesivir treatment, oxygenation parameters had improved allowing for patient transfer to a hospital
ward. |
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|
Soysal, A, Gönüllü, et al |
Jpn J Infect Dis |
Clinical data| Données cliniques |
Analyzed the usage of hydroxychloroquine in pediatric patients with COVID-19. The mean age of asymptomatic children
(118±62 months) was found to be higher than that of symptomatic children (89±69 months). Symptomatic children had a significantly lower mean lymphocyte count and higher mean CRP, D-dimer value, procalcitonin and LDH than asymptomatic children in univariate
analysis. Out of 156 children, 78 children received Hydroxychloroquine-containing regimen, 15 of them were treated with hydroxychloroquine + azithromycin + oseltamivir, 44 were treated with hydroxychloroquine + azithromycin and 21 were only treated with hydroxychloroquine.
Among the 156 patients who received medical treatment, 90 patients had pre and/or post-treatment ECG performed upon them. However, none of them either reported ECG abnormalities or a need for discontinuation of hydroxychloroquine because of adverse drug reaction. |
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|
Spurlin, EE, Han, et al |
J Minim Invasive Gynecol |
Healthcare Response | Réponse des soins de santé |
Assessed the impact of the coronavirus disease 2019 (COVID-19) pandemic on surgical volume and emergency department
(ED) consults across obstetric & gynecologic (OB/GYN) services at a New York City hospital. The volume and types of surgeries and ED consults were compared before and after the COVID-19 moratorium. During the pandemic, the average weekly volume of ED consults
and GYN surgeries decreased, while OB surgeries remained stable. The proportions of OBGYN ED consults, GYN surgeries, and OB surgeries relative to all ED consults, all surgeries, and all labor and delivery patients were 1.87%, 13.8%, 54.6% in the pre-COVID
timeframe (February 1 to March 15) versus 1.53%, 21.3%, 79.7% in the COVID timeframe (March 16 to April 15), representing no significant difference in proportions of OBGYN ED consults and GYN surgeries before and during COVID, with proportionate increase in
OB surgeries. The distribution of GYN surgical case types changed significantly during the pandemic with higher proportions of emergent surgeries for ectopics, miscarriages, and concern for cancer. Alternatively, the OB surgery distribution of case types remained
relatively constant. |
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|
Srivastava, A, Siddiqui, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Evaluated the antiviral potential of selected WS phytoconstituents against the novel SARS-CoV-2 target proteins and
human ACE2 receptor using in silico methods. Most of the phytoconstituents displayed good absorption and transport kinetics and were also found to display no associated mutagenic or adverse effect(s). Molecular docking analyses revealed that most of the WS
phytoconstituents exhibited potent binding to human ACE2 receptor, SAR-CoV and SARS-CoV-2 spike glycoproteins as well as the two main SARS-CoV-2 proteases. Most of the phytoconstituents were predicted to undergo Phase-I metabolism prior to excretion. All phytoconstituents
had favorable bioactivity scores with respect to various receptor proteins and target enzymes. SAR analysis revealed that the number of oxygen atoms in the withanolide backbone and structural rearrangements were crucial for effective binding. Molecular simulation
analyses of SARS-CoV-2 spike protein and papain-like protease with Withanolides A and B, respectively, displayed a stability profile at 300 K and constant RMSDs of protein side chains and Cα atoms throughout the simulation run time. |
|
|
Six cases of acute pulmonary embolism associated with COVID-19 |
Steeman, A, Mazairac, et al |
Revue medicale de Liege |
Clinical data| Données cliniques |
Article in French. Rising from the province of Wuhan in China, the new coronavirus SARS-CoV-2 broke out in winter 2019,
causing a global pandemic. In most cases reported, COVID-19 symptoms include cough, dyspnea, myalgia and asthenia. In some cases, the disease can also cause severe respiratory distress syndrome, requiring intensive care. Recent studies suggest that SARS-CoV-2
infection predisposes to thromboembolic event such as pulmonary embolism. Moreover, there is an overlap between signs and symptoms of pulmonary embolism and COVID-19, which brings a challenge for the diagnosis and could potentially be fatal. Nevertheless,
the incidence rate of pulmonary embolism in cases of COVID-19 is currently not known. In this paper we describe six cases of pulmonary embolism associated with COVID-19. |
|
Knowledge of Social Distancing Measures and Adherence to Restrictions during the COVID-19
Pandemic |
Sturman, D, Auton, et al |
Health Promot J Austr |
Public Health response| Interventions de santé publique |
Examined the role of knowledge and understanding of current social distancing measures in predicting intentions to
adhere to social distancing restrictions. Knowledge of social distancing restrictions predicted intentions to adhere in specific situations, but not general intentions to adhere. Knowledge of restrictions also predicted positive attitudes towards current restrictions
and a greater perceived ability to adhere to the restrictions, while positive attitudes was a good predictor of both general and specific intentions to adhere. |
|
Suebyat, K, Oyjinda, et al |
Engineering Letters |
Modelling/ prediction| Modélisation/prédiction Transmission |
Propose a mathematical model for the risk analysis of airborne infectious disease in an outpatient room. Not only considering
one type of person but also in this research, people are considered according to personal classifications. There are 4 types-patient, relative, worker, and outsider, staying in an outpatient room, which is in accordance with the real world. Air quality control
manipulations are simulated using the inlet and outlet ventilation rates adjustment under the condition of a number of surrounding people with a personal classified factor. The fourth-order Runge-Kutta (RK4) is used to approximate the model solution. The proposed
numerical model can be used to describe the dynamical dispersion of airborne infectious disease in an outpatient room. The results of the model are satisfactory, and it will be able to control airborne disease in more complicated structures. |
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Suhariati, HI, Yuswatiningsih, et al |
International Journal of Pharmaceutical Research |
Mental Health |
|
Analyzed the relationship between coping strategies and anxiety of mothers who have preschool children during the COVID-19
pandemic in a Kindergarten in Lawang. The results showed that most mothers had sufficient coping strategies as much as 28 (55%), and almost half experienced moderate anxiety as much as 21 (41%), the results of the Spearman Rank statistical test obtained p-value
= 0.000 <alpha value 0.05 so that H1 was accepted. The conclusion is that there is a relationship between coping strategies and the anxiety of mothers who have preschool children during the COVID-19 pandemic in a Kindergarten in Lawang. |
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Sui, Z, Zhang, et al |
J Infect |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Investigated the potential of saliva as an alternative specimen for coronavirus disease 2019 (COVID-19) diagnosis,
especially in low viral load samples, we recruited 35 recovered COVID-19 inpatients who showed no symptoms and long-term positive nucleic acid in the respiratory tract and totally collected 183 specimens of saliva, sputum, nasopharyngeal swab (NPS), oropharyngeal
swab (OPS), anal swab, and feces for reverse transcriptase digital polymerase chain reaction (RT-dPCR) evaluation. The positive rates of SARS-CoV-2 detection in saliva, sputum, NPS, OPS, anal swab, and feces were 86%, 79%, 93%, 83%, 64%, and 36%, respectively.
These results showed that NPS had the highest positive rate among the six types of specimens, followed by saliva detection that had slightly lower rate than NPS. |
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Sundaresan, T, Govindarajan, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission |
This paper obtains a classical SEIR model of transmission dynamics and clinical dynamics in controlling of coronavirus
disease 2019 (COVID-19) with Reproduction number. We discussed the parameter estimation of the transmission and clinical dynamics. The control of the COVID-19 was calculated by basic reproduction number. Therefore, the process was defined only epidemic calculator.
The reproduction number value of above one or less than one are defined the recovery percentage of the whole mathematical modeling. The estimations of the basic reproduction number level may be as high as 10 (99.97% recuperated). Finally we illustrate the
cure rate of the COVID-19 from the controlling of transmission dynamics parameters and also show the graphical representations from the numerical experiment. © 2020 Author(s). |
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|
Surendra, Henry, Elyazar, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This preprint study examined clinical characteristics and factors associated with in-hospital mortality of PCR−confirmed
COVID−19 patients in Jakarta, Indonesia, from March 2 to July 31, 2020. Of 4265 patients with a definitive outcome by July 31, 3768 (88%) were discharged and 497 (12%) died. Overall mortality was lower than reported in high-income countries, probably due
to younger age distribution and fewer comorbidities. However, deaths occurred across all ages, with >10% mortality among children <5 years and adults >50 years. |
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PMC7687369; Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2
infection in vitro |
Svenningsen, EB, Thyrsted, et al |
Antiviral Res |
Therapeutics| Thérapeutique |
Here, we have identified distinct members of the family of polyether ionophore antibiotics with potent ability to inhibit
SARS-CoV-2 replication and cytopathogenicity in cells. The compound X-206 displayed >500-fold selectivity between viral-induced cytopathogenicity and inhibition of cell viability and was furthermore able to inhibit viral replication even at sub-nM levels.
Collectively, our data suggest that polyether ionophore antibiotics should be subject to further investigations as potential broad-spectrum antiviral agents. |
|
Svyatchenko, VA, Nikonov, et al |
Photodiagnosis Photodyn Ther |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The purpose of this study was to evaluate the antiviral activity of photodynamic therapy (PDT) with methylene blue
(MB) and Radahlorin against SARS-CoV-2 in vitro. Vero E6 cells were protected from 104 TCID50 of SARS-CoV-2 by PDT post infection. Additionally, it was found that MB and Radahlorin also possess significant antiviral activity even without PDT. |
|
|
Tan, Eng Hooi, Sena, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
(Preprint) In this multinational network cohort study, we characterised 30-day outcomes and mortality after hospitalisation
with COVID-19 among patients with prevalent autoimmune diseases, and compared outcomes after hospital admissions among similar patients with seasonal influenza. We studied 133,589 patients diagnosed and 48,418 hospitalised with COVID-19 with prevalent autoimmune
diseases. Patients with autoimmune diseases had high rates of respiratory complications and 30-day mortality following a hospitalization with COVID-19. Compared to influenza, COVID-19 is a more severe disease, leading to more complications and higher mortality. |
|
|
Thompson, CP, Grayson, et al |
Eurosurveillance |
Epidemiology| Épidémiologie Immunology | Immunologie |
In this study, we used blood donors as a means of estimating population exposure from the start of the pandemic in
March through to mid-May when PCR-detected cases in the United Kingdom (UK) had plateaued. By using contact-traced asymptomatic individuals who had been PCR-confirmed as infected by SARS-CoV-2 and 100 blood donations obtained before the epidemic, we were able
to ascertain the sensitivity of the assay at 94.11% (95% CI: 79.17–99.98). Samples containing anti-SARS-CoV-2 neutralising antibodies were detected in blood donors who gave blood between 16 and 17 March 2020 in all Scottish health boards. Subsequently, samples
containing anti-SARS-CoV-2 neutralising antibodies were detected at every further time point assayed until the end of the study. |
|
|
Trieu, MC, Bansal, et al |
J Infect Dis |
Epidemiology| Épidémiologie Immunology | Immunologie |
Here, we characterized SARS-CoV-2-specific antibody responses in Norwegian HCW in a prospective cohort study. We enrolled
607 HCW pre- and post-the first COVID-19-pandemic wave. We found increases in SARS-CoV-2-neutralizing antibodies in infected HCW, especially after COVID-19-patient exposure. Our data show a low number of SARS-CoV-2-seropositive HCW in a low prevalence setting,
however, the proportion of seropositivity was higher than RT-PCR positivity, highlighting the importance of antibody testing. |
|
|
Urbine, Emma, James, et al |
medRxiv |
Epidemiology| Épidémiologie |
(Preprint) In the current study, we perform analysis of death rates due to COVID-19 data, obtained from the Center
for Disease Control and Prevention (CDC) for the current stage of the pandemic in the United States of America. Analysis of the death rates from August 1 to September 10, 2020, indicate that disparity continues with counties having higher population of Black
or African American people and female having higher death rates. Poverty is not a significant variable in determining the death rates due to COVID-19. |
|
|
Valent, F, Di Chiara, et al |
Clin Microbiol Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated this relation of duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the upper
respiratory tract and disease severity in the 530 000 inhabitants of the northeastern Italian province of Udine. Mean time to negativity was longer in the group admitted to the intensive care unit than in the others, whereas no difference was observed between
asymptomatic patients and those with mild disease. |
|
|
van Dam, PaulMEL, Zelis, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
(Preprint) We aimed to assess the value of several prediction models when applied to COVID-19 patients in the emergency
department (ED). All consecutive COVID-19 patients who visited the ED of a combined secondary/tertiary care center were included (n=403). The RISE UP score and 4C mortality score showed a very good discriminatory performance for 30-day mortality (AUC 0.83
and 0.84 respectively, 95% CI 0.79-0.88 for both), for 14-day mortality (AUC 0.83, 95% CI: 0.79-0.88, for both) and for the composite outcome (AUC 0.79 and 0.77 respectively, 95% CI 0.75-0.84). |
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van Halem, K, Bruyndonckx, et al |
BMC Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study describes the clinical characteristics, complications and outcomes of 319 hospitalized COVID-19 patients,
admitted to a tertiary care center at the start of the pandemic in Belgium, and aims to identify the main risk factors for in-hospital mortality in a European context using univariate and multivariate logistic regression analysis. Most patients hospitalized
with COVID-19 during the first weeks of the epidemic in Belgium were admitted with severe disease and the overall case fatality rate was high. The best predictors of in-hospital mortality in multivariate analysis were older age, and renal insufficiency, higher
lactate dehydrogenase and thrombocytopenia. |
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Vandenberg, B, Livingston, et al |
Addiction |
Public Health response| Interventions de santé publique |
This study aimed to compare beer consumption before and after restrictions to alcohol availability during the first
and second waves of COVID‐19 in Australia. Restricting the availability of on‐premises alcohol during the first and second waves of the COVID‐19 pandemic in Australia was associated with significant reductions in on‐premises beer consumption, but no significant
changes in off‐premises beer consumption. |
|
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Varani, S, Ostan, et al |
J Pain Symptom Manage |
Mental Health |
|
This study aimed to investigate the impact of Covid-19 pandemic on burnout and psychological morbidity among home home
PC professionals (PCPs) in Italy (n=145) . During the Covid-19 emergency, home PCPs presented a lower burnout frequency (p<.001) and higher level of personal accomplishment than in 2016 (p=.047). Conversely, the risk for psychological morbidity was significantly
higher during the pandemic (p<.001). |
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Two Stage Transformer Model for COVID-19 Fake News Detection and Fact Checking |
Vijjali, Rutvik, Potluri, et al |
arXiv |
Public Health response| Interventions de santé publique |
We developed a two stage automated pipeline for COVID-19 fake news detection using state of the art machine learning
models for natural language processing. The first model leverages a novel fact checking algorithm that retrieves the most relevant facts concerning user claims about particular COVID-19 claims. The second model verifies the level of truth in the claim by computing
the textual entailment between the claim and the true facts retrieved from a manually curated COVID-19 dataset. The dataset is based on a publicly available knowledge source consisting of more than 5000 COVID-19 false claims and verified explanations, a subset
of which was internally annotated and cross-validated to train and evaluate our models. |
|
Vos, ERA, den Hartog, et al |
J Epidemiol Community Health |
Epidemiology| Épidémiologie Immunology | Immunologie |
Participants (n=3207, aged 2–90 years), enrolled from a previously established nationwide serosurveillance study, provided
a self-collected fingerstick blood sample and completed a questionnaire (median inclusion date 3 April 2020) in this study to detect SARS-CoV-2 serum antibodies in the general population of the Netherlands and identify risk factors for seropositivity amidst
the first COVID-19 epidemic wave. In the midst of the first epidemic wave, 2.8% of the Dutch population was estimated to be infected with SARS-CoV-2, that is, 30 times higher than reported. This study identified independent groups with increased odds for seropositivity
that may require specific surveillance measures to guide future protective interventions internationally, including vaccination once available. |
|
|
The Kids Are Not Alright: A Preliminary Report
of Post-COVID Syndrome in University Students |
Walsh-Messinger, Julie, Manis, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Long-Term Sequelae |
|
This preliminary report investigates the prevalence and features of protracted symptoms in non-hospitalized university
students who experienced mild-to-moderate acute illness. Data from COVID-19 positive participants with symptoms ≥28 days (N=22) were compared to those who fully recovered (N=21) and those not diagnosed with COVID-19 (N=58). Our results contradict the perception
that this “yet to be defined” post-COVID syndrome predominantly affects middle-aged adults and suggest that exercise intolerance, dyspnea, chest pain, chemosensory impairment, lymphadenopathy, rhinitis, and appetite loss may differentiate post-COVID syndrome
from general symptoms of pandemic, age, and academic related stress. These findings are also consistent with previous reports that females are more vulnerable to this post viral syndrome. |
|
Wang, C, Zhou, et al |
Respir Res |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated 169 cases of COVID-19 pneumonia in two centers in Hunan Province, and divided them into two groups
according to epidemiological history, "imported patients" refers to patient with a clear history of travel in Wuhan within 14 days before onset, and " local patients” refers to local resident without a recent history of travel in Wuhan, aiming to analyze the
difference in clinical characteristics and outcomes between the two groups. In summary, we found that imported cases were more likely to develop into severe cases, compared with local patients and required more powerful treatments. |
|
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Studying social awareness of physical distancing in mitigating COVID-19 transmission |
Wang, X |
Mathematical Biosciences and Engineering |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this paper, we propose a dynamic model that incorporates individuals' behavior change in social interactions at
different stages of the epidemics. We fit our model to the data in Ontario, Canada and calculate the effective reproduction number Rt within each stage. We also investigate the effectiveness of disease intervention strategies. Simulations demonstrate that
enlarging the testing capacity and motivating infected individuals to test for an early diagnosis may facilitate mitigating the disease spread in a relatively short time. Results also indicate a significantly faster decline of confirmed positive cases if
individuals practice strict physical distancing even if restricted measures are lifted. |
|
Clinical features and short-term outcomes in COVID-19-infected patients with cancer |
Wang, Y, Shan, et al |
Cancer Management and Research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We performed a retrospective study in Wuhan Union Hospital from Feb 14, 2020, to Mar 15, 2020, China regarding the
clinical features and short-term outcomes of infected patients with cancer. Peripheral lymphocyte subset (CD3-positive and CD4-positive) on admission as a novel biomarker had a potential association with early efficacy. Cancer survivors in routine follow-up
would achieve better short-term outcomes. COVID-19 patients with cancer should gain more attention and close monitoring. |
|
Wang, Y, Wang, et al |
European review for medical and pharmacological sciences |
Healthcare Response | Réponse des soins de santé |
The study aimed to explore the best follow-up management strategy for patients undergoing peritoneal dialysis (PD)
during the novel coronavirus pneumonia (NCP) epidemic. Since January 2020, among the 580 patients undergoing PD who were followed up in our department and their families, none had NCP infection. The patient follow-up strategy during the epidemic period had
a significant positive effect on preventing and controlling the epidemic. Furthermore, during the epidemic period, encouraging patients and caregivers to pay attention to protection at home, avoid going out, strengthen self-management, and other measures were
beneficial to the control of kidney disease itself, which is worth promoting. |
|
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A risk assessment system of COVID-19 based on Bayesian inference |
Wei, J, Li, et al |
|
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We establish a Bayesian diagnosis network to deduce the risk probability related to the individual's detection information.
The system includes multiple handheld terminals and a cloud processing centre. The handheld terminal measures, records, and uploads the individual's physical information (e.g., body temperature, cough) and GPS information of the terminal. |
|
Wheaton, MG, Messner, et al |
J Obsessive Compuls Relat Disord |
Mental Health |
|
In the present study, we investigated whether intolerance of uncertainty (IU), a psychological vulnerability factor
involved in both OCD and health anxiety, accounts for a portion of the relationship between these symptoms and fear of COVID-19 during the early stages of the outbreak in the Unites States. Results revealed that concern about COVID-19 was moderately and positively
correlated with both OCD and health anxiety symptoms, as well as IU. Moreover, regression analyses found that IU partially accounted for the connections between concern about the spread of COVID-19 and OCD and health anxiety symptoms. |
|
|
[The early phase of the COVID-19 pandemic in Bavaria, Germany] |
Wjst, M |
Dtsch Med Wochenschr |
Epidemiology| Épidémiologie |
The objective of this study was to reconstruct the early phase of the 2020 COVID-19 pandemic in Bavaria from the official
case numbers of the Robert Koch Institute in Berlin as well as press and Twitter messages. The initial outbreak could be sufficiently covered using isolation and quarantine measurements, the consecutive early spreading falls into three phases, starting with
winter school holidays at the end of February, a number of beer festivals in the following week, and general elections on March, 15. The epidemic started with a few cases during the winter holidays, increased exponentially afterwards including significant
more cases by beer festivals and another significant excess of cases following the election that occurred in Bavaria only. |
|
A diary study of impulsive buying during the COVID-19 pandemic |
Xiao, H, Zhang, et al |
Current Psychology |
Mental Health |
|
The purpose of this paper is to explore why impulsive buying happens under emergency and crisis situations, such as
that of COVID-19. Through a multilevel structural equation model (MSEM) analysis, we found that the daily perceived uncertainty on COVID-19 affected daily information overload, which in turn stimulated daily information anxiety, ultimately determining the
daily impulsive buying. |
|
Xu, Y, Wu, et al |
Journal of Family Violence |
Mental Health |
|
This study aims to examine (1) the relationships between parenting stress, mental health, and grandparent kinship caregivers’
risky parenting practices, such as psychological aggression, corporal punishment, and neglectful behaviors towards their grandchildren during the COVID-19 pandemic, and (2) whether grandparent kinship caregivers’ mental health is a potential mediator between
parenting stress and caregivers’ psychological aggression, corporal punishment, and neglectful behaviors. Results suggest that decreasing grandparent kinship caregivers’ parenting stress and improving their mental health are important for reducing child maltreatment
risk during COVID-19. |
|
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COVID-19 and chronic renal disease: clinical characteristics and prognosis |
Yang, D, Xiao, et al |
QJM : monthly journal of the Association of Physicians |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study is to evaluate clinical characteristics, course and outcomes of COVID-19 patients with chronic
kidney disease (CKD) who did not require renal replacement therapy (RRT) and those on dialysis. Results find that COVID-19 patients with CKD presented high incidence of neutrophilia, poor prognosis and in-hospital death, with dialysis patients being more
vulnerable (OR = 2.00 (95% CI 0.52–7.63)). |
|
Design of COVID-19 Staged Alert Systems to Ensure
Healthcare Capacity with Minimal Closures |
Yang, Haoxiang, Sürer, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this study, we apply stochastic optimization to recommend policy triggers governing stages of community mitigation
to prevent overwhelming hospital surges and ensure adequate capacity in the unlikely case that they occur. Our data-driven optimization model is built atop a high fidelity SEIR-style (susceptible-exposed-infectious-recovered) simulation model of SARS-CoV-2
transmission. Our findings provide a robust strategy for tracking COVID-19 hospital admissions as an early indicator of hospital surges and enacting staged measures to ensure integrity of the health system, safety of the health workforce, and public confidence. |
|
Yoshimura, R, Okamoto, et al |
Case Reports in Psychiatry |
Mental Health |
|
We present a case of panic disorder induced by the coronavirus disease (COVID-19) pandemic in a patient with an organic
mood disorder. The patient was a 62-year-old woman with mild mood swings and reduced motivation and volition caused by a traumatic brain injury after a traffic accident. The present case suggests that vortioxetine augmentation can improve symptoms of depressive
state and panic disorder induced by the COVID-19 pandemic. |
|
|
An Agent-Based Study of the Impact of Sensitization on the Spread of Covid 19
in Burkina Faso |
Youl, E, Malo, et al |
|
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
We have studied in this paper the dynamics of the spread of the COVID-19 pandemic in Burkina Faso as well as when a
policy of awareness is put in place by the government. We use an agent-based approach. The results obtained show that the structure of contact networks has an influence on the information diffusion. |
|
Qualitative analysis of a fractional pandemic spread model of the novel coronavirus
(covid-19) |
Yousef, A, Bozkurt, et al |
Computers, Materials and Continua |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
In this study, we classify the genera of COVID-19 and provide brief information about the root of the spread and the
transmission from animal (natural host) to humans. We establish a model of fractional-order differential equations to discuss the spread of the infection from the natural host to the intermediate one, and from the intermediate one to the human host. At the
same time, we focus on the potential spillover of bat-borne coronaviruses. We consider the local stability of the co-existing critical point of the model by using the Routh–Hurwitz Criteria. Moreover, we analyze the existence and uniqueness of the constructed
initial value problem. We focus on the control parameters to decrease the outbreak from pandemic form to the epidemic by using both strong and weak Allee Effect at time t. Furthermore, the discretization process shows that the system undergoes Neimark–Sacker
Bifurcation under specific conditions. Finally, we conduct a series of numerical simulations to enhance the theoretical findings. |
|
T cell and antibody functional correlates of severe
COVID-19 |
Yu, KrystleKQ, Fischinger, et al |
medRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
We used multi-parameter flow cytometry and systems serology to comprehensively profile the functions of T cells and
antibodies targeting spike, nucleocapsid, and envelope proteins in a convalescent cohort of COVID-19 subjects who were either hospitalized (n=20) or not hospitalized (n=40). Surprisingly, we found that the magnitude and functional breadth of virus-specific
CD4 T cell and antibody responses were consistently higher among hospitalized subjects, particularly those with medical comorbidities. However, an integrated analysis identified more coordination between polyfunctional CD4 T-cells and antibodies targeting
the S1 domain of spike among subjects that were not hospitalized. These data reveal a functionally diverse and coordinated response between T cells and antibodies targeting SARS-CoV-2 which is reduced in the presence of comorbid illnesses that are known risk
factors for severe COVID-19. |
|
Yue, Z, Zhang, et al |
Nucleic Acids Res |
Coronavirology| Coronavirologie |
PAGER-CoV (http://discovery.informatics.uab.edu/PAGER-CoV/) is a new web-based database that can help biomedical researchers
interpret coronavirus-related functional genomic study results in the context of curated knowledge of host viral infection, inflammatory response, organ damage, and tissue repair. |
|
|
Zandehshahvar, Mohammadreza, van Assen, et al |
medRxiv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We report a new approach using artificial intelligence to study and classify the severity of COVID-19 using 1208 chest
X-rays (CXRs) of 396 COVID-19 patients obtained through the course of disease at Emory Healthcare affiliated hospitals (Atlanta, GA, USA). Using a two-stage transfer learning technique to train a convolutional neural network (CNN), we show that the algorithm
is able to classify four classes of disease severity (normal, mild, moderate, and severe) with average area under curve (AUC) of 0.93. |
|
|
Viral Pneumonia Screening on Chest X-rays Using Confidence-Aware Anomaly Detection |
Zhang, J, Xie, et al |
IEEE Trans Med Imaging |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We formulate the task of differentiating viral pneumonia from non-viral pneumonia and healthy controls into a one-class
classification-based anomaly detection problem. We therefore propose the confidence-aware anomaly detection (CAAD) model, which consists of a shared feature extractor, an anomaly detection module, and a confidence prediction module. When directly testing on
the X-COVID dataset that contains 106 COVID-19 cases and 107 normal controls without any fine-tuning, our model achieves an AUC of 83.61% and sensitivity of 71.70%, which is comparable to the performance of radiologists reported in the literature. |
|
Clinical analysis of 126 patients with coronavirus disease 2019 with
pharyngeal symptoms |
Zhang, W, Xu, et al |
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery |
Clinical data| Données cliniques |
The purpose of this study was to explore the clinical characteristics of patients with novel coronavirus pneumonia
(COVID-19) with pharyngeal symptoms in China (1,228 COVID-19 patients). The incidence of pharyngeal symptoms in COVID-19 patients was 10.26%, most of which occurred before or at the same time as the common symptoms of the disease. |
|
Zhao, S, Cao, et al |
BMC Oral Health |
Mental Health |
|
This study compared the anxiety level of the frontline dental staff (FDS) to the general public in Yichang during the
coronavirus disease of 2019 (COVID-19) pandemic and examined potential explanatory factors to the differences. In general, FDS were 4.342 (95% CI: 2.427–7.768) times more likely to suffer from anxiety disorders than the general public. The bivariate analysis
showed that age, Level Three Protective Measures (PM-3), conflicts with patients and/or colleagues were moderately associated with the anxiety state of FDS. But the knowledge of COVID-19, the treatment to suspected or confirmed cases both had a weak association
with the anxiety among FDS. |
|
|
Zheng, D, Luo, et al |
Tourism Management |
Mental Health |
|
This study explores what trigger the public's pandemic ‘travel fear’ and how people impose self-protection, coping
and resilience related to travel. The study integrates theories including protection motivation theory, coping and resilience theories to address the research aim. Results found that threat severity and susceptibility can cause ‘travel fear’, which leads to
protection motivation and protective travel behaviors after the pandemic outbreak. Findings also revealed that ‘travel fear’ can evoke different coping strategies, which increases people's psychological resilience and adoption of cautious travel behaviors. |
|
|
Zhou, J, He, et al |
Jpn J Infect Dis |
Clinical data| Données cliniques Immunology | Immunologie |
In this retrospective study, COVID-19 patients treated in Renmin Hospital of Wuhan University from Jan 7 to Feb 8,
2020 with measurements of serum IL-6 levels within 1 week after admission were included in order assess the prognostic value of IL-6. Serum IL-6 concentration was an independent predictor for a fatal outcome (P=0.04). The optimal cutoff value of serum IL-6
concentration for predicting fatal outcomes was 26.09 pg/mL (P < 0.001). |
|
|
|
Lancet Infect Dis |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We aimed to investigate the performance of four high-throughput commercial SARS-CoV-2 antibody immunoassays and a novel
384-well ELISA. At the manufacturers' thresholds, for the Abbott assay sensitivity was 92·7% (95% CI 90·2-94·8) and specificity was 99·9% (99·4-100%); for the DiaSorin assay sensitivity was 96·2% (94·2-97·7) and specificity was 98·9% (98·0-99·4); for the Oxford
immunoassay sensitivity was 99·1% (97·8-99·7) and specificity was 99·0% (98·1-99·5); for the Roche assay sensitivity was 97·2% (95·4-98·4) and specificity was 99·8% (99·3-100); and for the Siemens assay sensitivity was 98·1% (96·6-99·1) and specificity was
99·9% (99·4-100%). |
|
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Deep learning applications to combat the dissemination of COVID-19 disease: a review |
Alsharif, MH, Alsharif, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
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Augusterfer, EF, O'Neal, et al |
Curr Psychiatry Rep |
Review Literature| Revue de littérature |
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Review of registered clinical trials for the treatment of COVID-19 |
Babaei, F, Mirzababaei, et al |
Drug Dev Res |
Review Literature| Revue de littérature |
|
|
Bell, V, Wade, et al |
Soc Psychiatry Psychiatr Epidemiol |
Review Literature| Revue de littérature |
Rapid Review-MA: Although epidemic and pandemic response work may add only a small additional burden, improving mental
health through service management and provision of mental health services should be a priority given that baseline rates of poor mental health are already very high. As new studies emerge, they are being added to a living meta-analysis where all analysis code
and data have been made freely available: https://osf.io/zs7ne/ . |
|
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Berkmann, BJ |
Journal of Law, Religion and State |
Review Literature| Revue de littérature |
|
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Incidence of thromboembolism in patients with COVID-19: a systematic review and meta-analysis |
Boonyawat, K, Chantrathammachart, et al |
Thrombosis Journal |
Review Literature| Revue de littérature |
SR-MA: Medline, Embase, Scopus, and grey literature were searched until June 2020. The incidence of VTE in COVID-19
patients was higher in the ICU setting than in the non-ICU setting, and also significantly higher in studies that incorporated the CUS screening protocol. The incidence of ATE in the ICU setting was low. VTE prophylactic measures should be given to all hospitalized
patients diagnosed with COVID-19. |
|
Outdoor Transmission of SARS-CoV-2 and Other Respiratory Viruses, a Systematic Review |
Bulfone, TC, Malekinejad, et al |
J Infect Dis |
Review Literature| Revue de littérature |
SR: conducted a systematic review of peer-reviewed papers indexed in PubMed, EMBASE and Web of Science and pre-prints
in Europe PMC through August 12 th, 2020. Existing evidence supports the wide-held belief that the the risk of SARS-CoV-2 transmission is lower outdoors but there are significant gaps in our understanding of specific pathways. |
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Butenko, AV, Shekhter, et al |
Clinical Plasma Medicine |
Review Literature| Revue de littérature |
|
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Caparros-Gonzalez, R, Pérez-Morente, et al |
Nutrients |
Review Literature| Revue de littérature |
|
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Protease inhibitors targeting the main protease and papain-like protease of coronaviruses |
Capasso, C, Nocentini, et al |
Expert Opin Ther Pat |
Review Literature| Revue de littérature |
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Castillo-Zacarías, C, Barocio, et al |
Science of the Total Environment |
Review Literature| Revue de littérature |
|
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Diabetes and COVID-19: a major challenge in pandemic period? |
Chakraborty, C, Sharma, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
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Gastrointestinal involvement in children with SARS-COV-2 infection: An overview for the pediatrician |
Chiappini, E, Licari, et al |
Pediatric Allergy and Immunology |
Review Literature| Revue de littérature |
|
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COVID-19 and allergy: How to take care of allergic patients during a pandemic? |
Cianferoni, A, Votto, et al |
Pediatric Allergy and Immunology |
Review Literature| Revue de littérature |
|
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Dauby, N |
Revue medicale de Liege |
Review Literature| Revue de littérature |
|
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Duarte, ML, Santos, et al |
Sao Paulo medical journal = Revista paulista de medicina |
Review Literature| Revue de littérature |
SR-MA: search of the relevant literature was conducted in the PubMed, EMBASE, Cochrane Library, CINAHL and LILACS
databases, for articles published up to June 6, 2020. The high sensitivity and detection rates shown by CT demonstrate that this technique has a high degree of importance in the early stages of the disease. During an outbreak, the higher prevalence of the
condition increases the positive predictive value of CT. |
|
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Eljilany, I, Elzouki, et al |
Vascular Health and Risk Management |
Review Literature| Revue de littérature |
|
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The prevalence of type 2 diabetes in patients with COVID-19: a systematic review and meta-analysis |
Faghir-Gangi, M, Moameri, et al |
Clinical Diabetology |
Review Literature| Revue de littérature |
SR-MA: International scientific databases were searched until 15 April 2020. According to the results of this systematic
review, the prevalence of diabetes in patients with COVID-19 is higher in other countries compared to China. The prevalence of diabetes among COVID-19 patients was also significantly higher in men and elderlies. This evidence may be useful for health policymakers
to design suitable preventive and therapeutic interventions in patients with diabetes and COVID-19.
|
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COVID-19 and Cerebrovascular Diseases: A Systematic Review and Perspectives for Stroke Management |
Fraiman, P, Godeiro Junior, et al |
Frontiers in Neurology |
Review Literature| Revue de littérature |
SR: literature search on PubMed was performed including articles published from January 1, 2020, to July 23, 2020.
Cerebrovascular events are relatively common findings in COVID-19 infection, and they could have a multifactorial etiology. More accurate and prospective data are needed to better understand the impact of cerebrovascular events in COVID-19 infection.
|
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Galli, E, Cipriani, et al |
Pediatric Allergy and Immunology |
Review Literature| Revue de littérature |
|
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Girum, T, Lentiro, et al |
Tropical Medicine and Health |
Review Literature| Revue de littérature |
SR: databases such as PubMed/Medline, Global Health Database, Embase, CINAHL, Google Scholar, and clinical trial registries
were searched. Quarantine, contact tracing, screening, and isolation are effective measures of COVID-19 prevention, particularly when integrated together. In order to be more effective, quarantine should be implemented early and should cover a larger community.
|
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Gupta, U, Prakash, et al |
J Assoc Physicians India |
Review Literature| Revue de littérature |
|
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The Intersection between COVID-19, the Gene Family of ACE2 and Alzheimer’s Disease |
Haghighi, MM, Kakhki, et al |
Neuroscience Insights |
Review Literature| Revue de littérature |
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Haji Abdolvahab, M, Moradi-kalbolandi, et al |
International immunopharmacology |
Review Literature| Revue de littérature |
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Heriansyah, T, Chomsy, et al |
Scientia Pharmaceutica |
Review Literature| Revue de littérature |
|
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Javelot, H, Weiner, et al |
Encephale |
Review Literature| Revue de littérature |
|
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Jouret, G, Damsin, et al |
Revue medicale de Liege |
Review Literature| Revue de littérature |
|
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PMC7686796; Neuroimaging findings in COVID-19: A narrative review |
Katal, S, Gholamrezanezhad, et al |
Neurosci Lett |
Review Literature| Revue de littérature |
|
|
COVID19- clinical presentation and therapeutic considerations |
Kenny, G, Mallon, et al |
Biochemical and biophysical research communications |
Review Literature| Revue de littérature |
|
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Kermani-Alghoraishi, M |
Current problems in cardiology |
Review Literature| Revue de littérature |
|
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|
Kirubarajan, A, Khan, et al |
BMJ Open |
Review Literature| Revue de littérature |
ScR: English peer-reviewed studies published from January 1995 to June 2020 were included. Literature was identified
using four databases (Medline-OVID, EMBASE, CINAHL, Cochrane Library). There are promising strategies for overcoming face mask shortages during epidemics and pandemics. Further research specific to practical considerations is required before implementation
during the COVID-19 pandemic. |
|
|
Koh, CH |
Current problems in cardiology |
Review Literature| Revue de littérature |
|
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Lee, Y, Kirubarajan, et al |
American Journal of Surgery |
Review Literature| Revue de littérature |
SR: Medline, EMBASE, CENTRAL, and PubMed were systematically searched from database inception to July 1, 2020. This
review highlights postoperative patient outcomes during worldwide epidemics including the COVID-19 pandemic and identifies specific safety measures to minimize infection of healthcare workers. |
|
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Laboratory Perspective on Racial Disparities in Sexually Transmitted Infections |
Lieberman, JA, Cannon, et al |
J Appl Lab Med |
Review Literature| Revue de littérature |
|
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Longhitano, GA, Nunes, et al |
Progress in Additive Manufacturing |
Review Literature| Revue de littérature |
|
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Lukito, AA, Pranata, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Review Literature| Revue de littérature |
SR-MA: Several medical databases (Pubmed, EuropePMC, EBSCOhost, Proquest, Cochrane library) and two health-science
preprint servers (preprint.org and Medrxiv) were systematically searched for relevant literature. The analysis showed that metformin consumption was associated with lower mortality. Randomized controlled trials are needed to confirm this finding.
|
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Lundholm, MD, Poku, et al |
Journal of the Endocrine Society |
Review Literature| Revue de littérature |
|
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Maccari, L, Cagno, et al |
Comput Commun |
Review Literature| Revue de littérature |
|
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Madjunkov, M, Dviri, et al |
J Ovarian Res |
Review Literature| Revue de littérature |
|
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Malas, MB, Naazie, et al |
EClinicalMedicine |
Review Literature| Revue de littérature |
SR-MA: searched PubMed, Cochrane, and Embase for studies published up to June 12, 2020. TE rates of COVID-19 are high
and associated with higher risk of death. Robust evidence from ongoing clinical trials is needed to determine the impact of thromboprophylaxis on TE and mortality risk of COVID-19. |
|
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Cochrane corner: Video calls for reducing social isolation and loneliness in older people |
Malinga, T, Schmidt, et al |
Pan African Medical Journal |
Review Literature| Revue de littérature |
|
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Marchetta, S, Lambermont, et al |
Revue medicale de Liege |
Review Literature| Revue de littérature |
|
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Marschke, M, Vandergeest, et al |
Maritime Studies |
Review Literature| Revue de littérature |
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Meher, BR, Padhy, et al |
J Assoc Physicians India |
Review Literature| Revue de littérature |
SR-MA: Though the review suggests modest utility of CPT in reducing all-cause mortality, improving clinical outcome,
and early viral clearance, it should be interpreted cautiously. |
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Mirzaei, R, Mahdavi, et al |
International immunopharmacology |
Review Literature| Revue de littérature |
|
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Moghimi, M, Khodadadi, et al |
Journal of Advances in Medical and Biomedical Research |
Review Literature| Revue de littérature |
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Mouffouk, C, Mouffouk, et al |
Eur J Pharmacol |
Review Literature| Revue de littérature |
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PMC7687409; What can we learn from brain autopsy in COVID-19? |
Mukerji, SS, Solomon, et al |
Neurosci Lett |
Review Literature| Revue de littérature |
|
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PMC7686787; Neurological issues during COVID-19: An Overview |
Nath, A, Smith, et al |
Neurosci Lett |
Review Literature| Revue de littérature |
|
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Nguyen, T, Gosine, et al |
|
Review Literature| Revue de littérature |
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Cochrane corner: Convalescent plasma or hyperimmune immunoglobulin for people with covid-19 |
Nnaji, CA, Wiysonge, et al |
Pan African Medical Journal |
Review Literature| Revue de littérature |
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Omolaoye, TS, Adeniji, et al |
Reprod Toxicol |
Review Literature| Revue de littérature |
|
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SARS-CoV-2 infection and neonates: a review of evidence and unresolved questions |
Pietrasanta, C, Ronchi, et al |
Pediatric Allergy and Immunology |
Review Literature| Revue de littérature |
|
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Pimentel, J, Laurie, et al |
Br J Clin Pharmacol |
Review Literature| Revue de littérature |
ScR: review searched Pubmed, Embase (Ovid), Scopus, and 17 primary trial registries. The results of the 23 registered
active trials, including more than 30,000 participants, will shed light on the efficacy and safety of the antiviral. The findings of the remaining clinical trials expected to report results in 2020 will allow a quantitative synthesis of available evidence. |
|
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Incubation period of COVID-19: A systematic review and meta-analysis |
Quesada, JA, López-Pineda, et al |
Revista clinica espanola |
Review Literature| Revue de littérature |
SR-MA: search was conducted using Pubmed, Scopus/EMBASE, and the Cochrane Library databases, covering all observational
and experimental studies reporting the incubation period and published from 1 January 2020 to 21 March 2020. Based on the published data reporting the incubation period of COVID-19, the mean time between exposure and onset of clinical symptoms depended on
the statistical model used, and the 95th percentile depended on the mean age of the patients. It is advisable to record sex and age when collecting data in order to analyze possible differential patterns.
|
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Coronaviruses in Children: A Review of Potential Mechanisms of Childhood Protection |
Rabi, FA, Al Zoubi, et al |
Acta Paediatr |
Review Literature| Revue de littérature |
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Rafiullah, M, Siddiqui, et al |
J Comp Eff Res |
Review Literature| Revue de littérature |
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Current COVID-19 vaccine candidates: Implications in the Saudi population |
Raja, AT, Alshamsan, et al |
Saudi Pharmaceutical Journal |
Review Literature| Revue de littérature |
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Ray, PS, Goswami, et al |
Indian Journal of Biochemistry and Biophysics |
Review Literature| Revue de littérature |
|
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Ryan, J, Okeibunor, et al |
Pan African Medical Journal |
Review Literature| Revue de littérature |
Rapid Review: searched for eligible studies in PubMed, Scopus, and Google Scholar in April 2020. this review highlights
the importance of timeous action when faced with an epidemic, let alone a pandemic. The setting up and relaxation of public measures are time sensitive and data-driven actions. In the absence of a safe and effective vaccine, these findings are relevant for
the sustainable containment of COVID-19 in African countries. |
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Proportion of newly diagnosed diabetes in COVID-19 patients: a systematic review and meta-analysis |
Sathish, T, Kapoor, et al |
Diabetes Obes Metab |
Review Literature| Revue de littérature |
SR-MA |
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Scerri, M, Grech, et al |
Early human development |
Review Literature| Revue de littérature |
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DPP-4 inhibition and COVID-19: From initial concerns to recent expectations |
Scheen, AJ |
Diabetes Metab |
Review Literature| Revue de littérature |
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Singh, H, Chauhan, et al |
European journal of pharmacology |
Review Literature| Revue de littérature |
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Singh, KP, Sasadeusz, et al |
Microbiology Australia |
Review Literature| Revue de littérature |
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Sinha, S, Mittal, et al |
International Journal of Current Research and Review |
Review Literature| Revue de littérature |
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Sougou, NM, Diouf, et al |
Pan African Medical Journal |
Review Literature| Revue de littérature |
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Covid-19 challenges and human resource management in organized retail operations |
Sulaiman, MABA, Ahmed, et al |
Utopia y Praxis Latinoamericana |
Review Literature| Revue de littérature |
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Perinatal COVID-19 outcomes: evaluating the strength of current evidence |
Sulentic, RO, Seferovic, et al |
J Matern Fetal Neonatal Med |
Review Literature| Revue de littérature |
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Therapeutic Drug Monitoring and Individualized Medication of Ribavirin |
Tan, ZY, Yu, et al |
Chinese Pharmaceutical Journal |
Review Literature| Revue de littérature |
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A brief review of the neurological manifestations of the coronavirus disease |
Unnithan, AKA |
Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
Review Literature| Revue de littérature |
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CRISPR-based biosensing systems: a way to rapidly diagnose COVID-19 |
Vatankhah, M, Azizi, et al |
Crit Rev Clin Lab Sci |
Review Literature| Revue de littérature |
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Wang, KC, Xiao, et al |
Journal of Orthopaedics |
Review Literature| Revue de littérature |
SR-MA: MEDLINE (PubMed) and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases. The overall
pooled mortality rate in the early postoperative period for hip fracture patients with concomitant COVID-19 infection was 32.6%. The relative risk for postoperative mortality in COVID-positive patients compared to non-COVID patients was 5.66 (95% CI 4.01–7.98;
p < 0.001). |
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Arrhythmia in patients with severe coronavirus disease (COVID-19): a meta-analysis |
Wen, W, Zhang, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
MA:searched PubMed, Embase, Web of Science, and the Cochrane Library for case control studies that were published between
January 1 and July 25, 2020. This study showed that the incidence of arrhythmia in patients with severe COVID-19 was greater than that of those with non-severe COVID-19. Patients with severe COVID-19 had a higher risk of arrhythmia complications, which further
showed that COVID-19 may be a risk factor for arrhythmia and that the incidence of arrhythmia may increase with the progression of the disease. More importantly, this meta-analysis graded the reliability of evidence for further basic and clinical research
into arrhythmia in patients with COVID-19. |
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Xiao, WW, Xu, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
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Herd immunity against COVID-19: is it enough to stop a second wave? |
AbdAllah, M, Cordie, et al |
New Microbes and New Infections |
Commentary/Editorial| Commentaire/Éditorial |
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Abdoli, A |
J Med Econ |
Commentary/Editorial| Commentaire/Éditorial |
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Abou-Ismail, M, Diamond, et al |
Thromb Res |
Commentary/Editorial| Commentaire/Éditorial |
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Fasting Ramadan During COVID-19 Pandemic: Immunomodulatory Effect |
Abunada, T, Abunada, et al |
Frontiers in Nutrition |
Commentary/Editorial| Commentaire/Éditorial |
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Adekoya, OB, Oliyide, et al |
Resources Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Adges, J |
Drama Therapy Review |
Commentary/Editorial| Commentaire/Éditorial |
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Agostinucci, JM |
Soins Aides - Soignantes |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7687404; Clinical preventive services to reduce pandemic deaths |
Agrawal, S, Gołębiowska, et al |
Prev Med Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Ahmed, I, McDonnell, et al |
Progress in Disaster Science |
Commentary/Editorial| Commentaire/Éditorial |
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The critical role of complete blood count in the management of patients with covid-19 |
Ahnach, M, Bouanani, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Alangaden, GJ, Mayur, et al |
Am J Transplant |
Commentary/Editorial| Commentaire/Éditorial |
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Al-Faouri, I, Haddad, et al |
Ann Med Surg (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
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Finance, financiers and financial centres: A special issue in honour of Youssef Cassis Introduction |
Altamura, CE, Daunton, et al |
Financial History Review |
Commentary/Editorial| Commentaire/Éditorial |
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Electrophysiology Practice During COVID-19 Pandemic: A New York Tertiary Hospital Experience |
Anca, D, Reyes, et al |
Journal of cardiothoracic and vascular anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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It’s X-Related: Biological bases of increased COVID-19 morbidity and mortality in men |
Angelides, PK, Jindal, et al |
Journal of the Endocrine Society |
Commentary/Editorial| Commentaire/Éditorial |
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Mental health services in the wake of COVID-19 and opportunities for change |
Arnone, D |
Br J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Avery, EJ, Park, et al |
Health Commun |
Commentary/Editorial| Commentaire/Éditorial |
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Balibrea, JM, Morales-Conde, et al |
Cirugia Espanola |
Commentary/Editorial| Commentaire/Éditorial |
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Public Policy Lessons from the COVID-19 Outbreak: How to Deal with it in the Post-Pandemic World? |
Basher, Syed Abul, Haque, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 insidious trick: subjective perception of numbers |
Bassetti, M, Giacobbe, et al |
Eur J Clin Invest |
Commentary/Editorial| Commentaire/Éditorial |
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Begović, N |
Journal of Law, Religion and State |
Commentary/Editorial| Commentaire/Éditorial |
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Resilience and responsiveness of general practice during the COVID-19 pandemic |
Belche, JL, Joly, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
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Bemquerer, LM, de Arruda, et al |
J Am Acad Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Benish, A, Levi-Faur, et al |
Annals of the American Academy of Political and Social Science |
Commentary/Editorial| Commentaire/Éditorial |
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Bertini, M, Ferrari, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Impaired type I interferon response in SARS-CoV-2 infection: looking through the cutaneous window |
Bessis, D |
Br J Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Biadgilign, S, Yigzaw, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Medical strategies in nursing homes during the COVID-19 pandemic: A Brazilian experience |
Blasco, PG, de Benedetto, et al |
Aust J Gen Pract |
Commentary/Editorial| Commentaire/Éditorial |
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Boaz, DN |
Journal of Law, Religion and State |
Commentary/Editorial| Commentaire/Éditorial |
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Boyle, EC, Haverich, et al |
Eur J Cardiothorac Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Meta Governance of Path Dependencies: Regulation, Welfare, and Markets |
Braithwaite, J |
Annals of the American Academy of Political and Social Science |
Commentary/Editorial| Commentaire/Éditorial |
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Breast Cancer Management During COVID-19 Pandemic in Madrid: Surgical Strategy |
Brenes Sánchez, JM, Picado, et al |
Clinical Breast Cancer |
Commentary/Editorial| Commentaire/Éditorial |
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Bricmont, N, Benchimol, et al |
Journal of Visualized Experiments |
Commentary/Editorial| Commentaire/Éditorial |
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Briggs, DC, Numbere, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 Transport Analytics: Analysis of Rome Mobility During Coronavirus Pandemic Era |
Brinchi, S, Carrese, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Buxeraud, J |
Actual Pharm |
Commentary/Editorial| Commentaire/Éditorial |
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The use of combined hormonal contraceptives amid the COVID-19 pandemic. Reply |
Cagnacci, A, Fruzzetti, et al |
Eur J Contracept Reprod Health Care |
Commentary/Editorial| Commentaire/Éditorial |
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Understanding the SARS-CoV-2 pandemic as evolution in action |
Cairns, W |
Microbiology Australia |
Commentary/Editorial| Commentaire/Éditorial |
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The European Bioinformatics Institute: empowering cooperation in response to a global health crisis |
Cantelli, G, Cochrane, et al |
Nucleic Acids Res |
Commentary/Editorial| Commentaire/Éditorial |
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Carli, P |
Journal Europeen des Urgences et de Reanimation |
Commentary/Editorial| Commentaire/Éditorial |
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Carrasco, JP, Herraiz, et al |
Rev Psiquiatr Salud Ment |
Commentary/Editorial| Commentaire/Éditorial |
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Casu, C |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Literacy in Lockdown: Learning and Teaching During COVID-19 School Closures |
Chamberlain, L, Lacina, et al |
Reading Teacher |
Commentary/Editorial| Commentaire/Éditorial |
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Race-Related disparities in COVID-19 thrombotic outcomes: Beyond
social and economic explanations |
Chaudhary, R, Bliden, et al |
EClinicalMedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Proactive and blended approach for COVID-19 control in Taiwan |
Cheng, HY, Huang, et al |
Biochemical and biophysical research communications |
Commentary/Editorial| Commentaire/Éditorial |
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Cheng, X, Han, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Chu, CT, Rogers, et al |
Sex Transm Infect |
Commentary/Editorial| Commentaire/Éditorial |
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Ciavarella, A, Erra, et al |
Int J Gynaecol Obstet |
Commentary/Editorial| Commentaire/Éditorial |
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Coelho, CM, Suttiwan, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Coffey, VC |
Photonics Spectra |
Commentary/Editorial| Commentaire/Éditorial |
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Conover, J |
Drama Therapy Review |
Commentary/Editorial| Commentaire/Éditorial |
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Consoli, F, Cristini, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Constant, E |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
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Editorial - COVID-19: Exemplifying the importance and challenges of Acute Medicine |
Cooksley, T |
Acute medicine |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 pandemic : a real opportunity for digital health |
Coucke, C, Coucke, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
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Cold working environments as an occupational risk factor for COVID-19 |
Cunningham, L, Nicholson, et al |
Occup Med (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
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Curtis, S, Flower, et al |
BMJ Simulation and Technology Enhanced Learning |
Commentary/Editorial| Commentaire/Éditorial |
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Dahmen, J, Bäker, et al |
Anaesthesist |
Commentary/Editorial| Commentaire/Éditorial |
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Water management beyond the fortressed COVID-19 world: considerations for the long-term |
Daniell, KA |
Australian Journal of Water Resources |
Commentary/Editorial| Commentaire/Éditorial |
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Dantjie, P, Setyaningsih, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
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[Wearing a mask during childbirth: what real impact on delivery issues?] |
Dap, M, Bertholdt, et al |
Gynecol Obstet Fertil Senol |
Commentary/Editorial| Commentaire/Éditorial |
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Davenne, E, Giot, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
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de Bilbao, GM |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
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Severe COVID-19, a new complication to be added to numerous comorbidities associated to obesity |
De Flines, J, Scheen, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
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Reply: Insights From HeartLogic Multisensor Monitoring During the COVID-19 Pandemic in New York
City |
DeFilippis, EM, Reza, et al |
JACC: Heart Failure |
Commentary/Editorial| Commentaire/Éditorial |
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Severe acute respiratory syndrome coronavirus 2 infection prevention in orthodontic practice |
Di Blasio, A, Barenghi, et al |
Am J Orthod Dentofacial Orthop |
Commentary/Editorial| Commentaire/Éditorial |
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A multifactorial score including autophagy for prognosis and care of COVID-19 patients |
Domdom, MA, Brest, et al |
Autophagy |
Commentary/Editorial| Commentaire/Éditorial |
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The coronavirus pandemic—a politically explosive catastrophe |
Dörre, K |
Berliner Journal fur Soziologie |
Commentary/Editorial| Commentaire/Éditorial |
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Drewes, M, Daumann, et al |
List Forum fur Wirtschafts- und Finanzpolitik |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 impacts at a small mid-atlantic liberal-arts college with implications for stem
education |
D'Souza, MJ, Fry, et al |
Journal of Education and e-Learning Research |
Commentary/Editorial| Commentaire/Éditorial |
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Du, L, Raposo, et al |
JMIR Mhealth Uhealth |
Commentary/Editorial| Commentaire/Éditorial |
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Dusnaevich, RU |
International Journal of Current Research and Review |
Commentary/Editorial| Commentaire/Éditorial |
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Edwards, C |
J Clin Endocrinol Metab |
Commentary/Editorial| Commentaire/Éditorial |
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Elgendy, IY, Pepine, et al |
Int J Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
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Elkaddoum, R, Haddad, et al |
Future Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Endomba, FT, Bigna, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Erpicum, P, Grosch, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
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Evans, C |
Business Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Rethinking Serious Games Design in the Age of COVID-19: Setting the Focus on Wicked Problems |
Fabricatore, C, Gyaurov, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Salient points to observe in mass ceremonies during the COVID-19 pandemic |
Farahani, AJ, Hassanpour, et al |
Trauma Monthly |
Commentary/Editorial| Commentaire/Éditorial |
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Ferrara, P, Franceschini, et al |
Journal of Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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Death policies: Covid-19 and the labyrinths of the black city |
Flauzina, A, Pires, et al |
Revista Brasileira de Politicas Publicas |
Commentary/Editorial| Commentaire/Éditorial |
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Follmer, C |
ACS Chem Neurosci |
Commentary/Editorial| Commentaire/Éditorial |
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Fujita, M, Matsuoka, et al |
Tropical Medicine and Health |
Commentary/Editorial| Commentaire/Éditorial |
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Gabbie, S, Man, et al |
Arch Dis Child Educ Pract Ed |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 pandemic and its repercussions in our interventional radiology unit |
García, IC, Molina, et al |
Radiologia |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in accommodation facilities for dependent elderly, testimony from a healthcare executive |
Garcia, L |
Soins Gerontologie |
Commentary/Editorial| Commentaire/Éditorial |
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García-Cosío, MD, Flores Hernán, et al |
Rev Esp Cardiol (Engl Ed) |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7686825; Considerations for planning COVID-19 treatment services in humanitarian responses |
Garry, S, Abdelmagid, et al |
Confl Health |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and systemic anticancer therapy: exploiting uncertainty |
Gelderblom, Hans, Veelken, et al |
The Lancet Oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Giacomet, V, Stracuzzi, et al |
Pediatric Allergy and Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7687583; Neuro-Ophthalmologic Complications of Coronavirus Disease 2019 (COVID-19) |
Gold, DM, Galetta, et al |
Neurosci Lett |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7685955; Video-Assisted Peritoneal Dialysis Placement in COVID-19 Patients |
Graham, JA, Torabi, et al |
Kidney Med |
Commentary/Editorial| Commentaire/Éditorial |
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Green, A |
Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Surveillance, Security, and Liberal Democracy in the Post-COVID World |
Greitens, SC |
International Organization |
Commentary/Editorial| Commentaire/Éditorial |
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Gross, B, Zheng, et al |
EPL |
Commentary/Editorial| Commentaire/Éditorial |
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Chest radiological lesions in COVID-19 : from classical imaging to artificial intelligence |
Guiot, J, Danthine, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
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Households, bubbles and hugging grandparents: Caring and lockdown rules during COVID-19 |
Gulland, J |
Feminist Legal Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: What Sweden taught Scandinavia for the second wave |
Habib, H |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Haddad, FS |
Bone Joint J |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7687400; [The COVID-19 crisis, revealing the challenges of computational psychiatry] |
Haliday, H, Gauld, et al |
Ann Med Psychol (Paris) |
Commentary/Editorial| Commentaire/Éditorial |
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A village health center budgeting in the good local governance during COVID-19 pandemic |
Handini, S, Sari, et al |
International Journal of Pharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Harvey, S, Jennings, et al |
Drama Therapy Review |
Commentary/Editorial| Commentaire/Éditorial |
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Economic consequences of COVID-19 in the middle east and north Africa region countries |
Hashemi-Shahri, S, Barfar, et al |
Journal of Advances in Medical and Biomedical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Hayette, MP, Meex, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
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Hazim, A, Yacoubi, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7686813; A virtual teaching clinic for virtual care during the COVID-19 pandemic |
He, X, Shelden, et al |
Clin Diabetes Endocrinol |
Commentary/Editorial| Commentaire/Éditorial |
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The Social Group Distinction of Nationalists and Globalists amid COVID-19 Pandemic |
He, Z, Chen, et al |
Fudan Journal of the Humanities and Social Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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High impact of SARS-CoV-2/COVID-19 in the Honduran Health Personnel |
Henriquez-Marquez, K, Lainez-Murillo, et al |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hypoxic preconditioning - a non-pharmacological approach in COVID-19 prevention |
Hertzog, RG, Bicheru, et al |
Int J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
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Hessami, K |
J Matern Fetal Neonatal Med |
Commentary/Editorial| Commentaire/Éditorial |
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Finding my raison d’être: Covid-19 and the call to online therapy |
Hill, MA |
Drama Therapy Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Horton, R |
Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Why METH users are at high risk of fatality due to COVID-19 infection? |
Hossain, MK, Hassanzadeganroudsari, et al |
Expert Rev Vaccines |
Commentary/Editorial| Commentaire/Éditorial |
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Hossain, SQ, Ahmed, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
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Howe, DC, Chauhan, et al |
Organizational dynamics |
Commentary/Editorial| Commentaire/Éditorial |
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Hsu, H, Greenwald, et al |
J Am Med Inform Assoc |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7577871; Guillain Barré syndrome and COVID-19: Possible role of the cytokine storm |
Hussain, FS, Eldeeb, et al |
Autoimmun Rev |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7676366; The impact of COVID-19 pandemic on the cardiology services in Northern Jordan |
Ibdah, R, Rawashdeh, et al |
Ann Med Surg (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ibrahim, F, Susanto, et al |
Applied System Innovation |
Commentary/Editorial| Commentaire/Éditorial |
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Ilare, S, Grognet, et al |
Soins Gerontologie |
Commentary/Editorial| Commentaire/Éditorial |
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Overcoming covid-19 in west african countries: Is herd immunity an option? |
Ilesanmi, OS, Akande, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ionescu, AC, Brambilla, et al |
Oral Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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Isaacs, D |
Microbiology Australia |
Commentary/Editorial| Commentaire/Éditorial |
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|
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Janapala, RN, Patel, et al |
Int J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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Psychopharmacotherapeutic guidelines : a challenge during health crisis |
Javelot, H, Samalin, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
|
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Organisation of cancer care during the COVID-19 pandemic : experience from CHU Liège |
Jérusalem, G |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
|
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Life after COVID-19: The importance of a safe return to physical activity |
Jewson, J, McNamara, et al |
Aust J Gen Pract |
Commentary/Editorial| Commentaire/Éditorial |
|
|
jha, D, Sharma, et al |
Biochemical and Cellular Archives |
Commentary/Editorial| Commentaire/Éditorial |
|
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Jha, SS, Lahiri, et al |
Rural and remote health |
Commentary/Editorial| Commentaire/Éditorial |
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Food Systems and Health: Prospects for Hope in the Brazilian Chaos? |
Johns, P |
Development (Basingstoke) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Challenges posed by covid-19 to patients with cancer: Lessons from a moroccan experience |
Kaikani, W, Mohammed, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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PMC7413659; SARS-CoV-2 epidemic in African countries-are we losing perspective? |
Kalk, A, Schultz, et al |
Lancet Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7676315; The ethics in society during the COVID-19 outbreak in Iran |
Kamran, A, Naeim, et al |
Ethics Med Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Applying the principle 'First Do No Harm' during the pandemic |
Katheria, A, Koo, et al |
Bjog |
Commentary/Editorial| Commentaire/Éditorial |
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Hif-1α contributing to COVID-19 infections and poor prognosis in cancer patients
– a hypothesis |
Kaur, R, Chauhan, et al |
Indian Journal of Biochemistry and Biophysics |
Commentary/Editorial| Commentaire/Éditorial |
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War in the time of COVID-19: humanitarian catastrophe in Nagorno-Karabakh and Armenia |
Kazaryan, AirazatM, Edwin, et al |
The Lancet Global Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ketfi, A, Chabati, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7685944; COVID-19 Pandemic: Mechanistic approaches and gender vulnerabilities |
Khan, L, Ul Khaliq, et al |
Saudi Pharm J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kia, V, Teimouri, et al |
Journal of Advances in Medical and Biomedical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19 |
Kirschenbaum, D, Imbach, et al |
Neuropathol Appl Neurobiol |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kirton-Darling, E, Carr, et al |
Journal of Law and Society |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations for treatment of critically ill patients with COVID-19 |
Kluge, S, Janssens, et al |
Anaesthesist |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kordova, S, Keisari, et al |
Drama Therapy Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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The use of combined hormonal contraceptives amid the COVID-19 pandemic |
Kow, CS, Mustafa, et al |
Eur J Contracept Reprod Health Care |
Commentary/Editorial| Commentaire/Éditorial |
|
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Selenium, a micronutrient can modulate viral diseases
including COVID-19 |
Kunwar, A, Priyadarsini, et al |
Indian Journal of Biochemistry and Biophysics |
Commentary/Editorial| Commentaire/Éditorial |
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|
Lagos-Ortiz, K, Jácome-Murillo, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lahri, S |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lai, CC, Chen, et al |
J Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Laing, AG, Lorenc, et al |
Nat Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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Staring into a blue circle: Reflections on school-based drama therapy during COVID-19 |
Landis, H, Hughes, et al |
Drama Therapy Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 and breast cancer: may the microbiome be the issue? |
Lasagna, A, Zuccaro, et al |
Future Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
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New technologies used in COVID-19 for business survival: Insights from the Hotel Sector in China |
Lau, A |
Information Technology and Tourism |
Commentary/Editorial| Commentaire/Éditorial |
|
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Lee, D, Lee, et al |
Educational Technology Research and Development |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19's impact on travel medicine surpasses that of all other emerging viral diseases |
Leong, WY |
J Travel Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Levi, M, Miglietta, et al |
J Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
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Effect of the COVID-19 Pandemic on Postacute Care Decision Making |
Levin, SR, Gitkind, et al |
Archives of Physical Medicine and Rehabilitation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A Test-Based Strategy for Safely Shortening Quarantine
for COVID-19 |
Lewis, Dana, Leibrand, et al |
medRxiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Designing Moodle features as e-learning for learning mathematics in COVID-19 pandemic |
Lisnani, L, Putri, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Health Care Workers in Covid-19: From Lockdown
to Unlock and Beyond! |
Londhe, C, Londhey, et al |
J Assoc Physicians India |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Louis, R, Calmes, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
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Organization of Labor Activity at Construction Enterprise During the Spread of Coronavirus |
Lovcheva, MV |
|
Commentary/Editorial| Commentaire/Éditorial |
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Lowbridge, C, Ralph, et al |
Microbiology Australia |
Commentary/Editorial| Commentaire/Éditorial |
|
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Recurrent Covid-19 Pneumonia in the course of chemotherapy: consequence of a weakened immune system? |
Luciani, M, Bentivegna, et al |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Combating the SARS-CoV-2 pandemic: How can the field of human genetics contribute? |
Ludwig, KU, Schmidt, et al |
Medizinische Genetik |
Commentary/Editorial| Commentaire/Éditorial |
|
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MacKenzie, SC, Cumming, et al |
BMJ Innovations |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Madhav, A, Mehrotra, et al |
Semin Immunol |
Commentary/Editorial| Commentaire/Éditorial |
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Mahase, E |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Humanistic and mental health behaviorism in shaping the learning process in covid-19 outbreak |
Mahbub, M, Syarifudin, et al |
International Journal of Pharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Mahmud, MR, Cheserem, et al |
World Neurosurg |
Commentary/Editorial| Commentaire/Éditorial |
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Mallhi, TH, Khan, et al |
Clin Microbiol Infect |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19, hypertension, and RAAS blockers: the BRACE-CORONA trial |
Mancia, G |
Cardiovasc Res |
Commentary/Editorial| Commentaire/Éditorial |
|
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Going first: the ethics of vaccine self-experimentation in coronavirus times |
Manríquez Roa, T, Biller-Andorno, et al |
Swiss Med Wkly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Marinho, PM, Marcos, et al |
EClinicalMedicine |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7588795; COVID-19 and immune-mediated inflammatory diseases: Why don't our patients get worse? |
Martínez-Taboada, VM, López-Hoyos, et al |
Autoimmun Rev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Marzolini, C, Stader, et al |
Drug Saf |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mazy, C, Boniver, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
McKinney, J, Connelly, et al |
Can J Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
SARS-CoV-2 and the risk of Parkinson's disease: facts and fantasy |
Merello, Marcelo, Bhatia, et al |
The Lancet Neurology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Meyer, CP, Kaulfuss, et al |
Eur Urol |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mineta, K, Goto, et al |
Clin Genet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mishna, F, Milne, et al |
Clinical Social Work Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mitra, A, Rahman, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Organizational and Economic Mechanism of Staff Turnover Management |
Mitrofanova, EA, Mitrofanova, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Protecting the vulnerable during COVID-19: Treating and preventing chronic disease disparities |
Mobula, LM, Heller, et al |
Gates Open Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Molnar, MZ, Kovesdy, et al |
Am J Transplant |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A word for the nephrologist: What we changed in our habits during the covid-19 pandemic? |
Montasser, DI, Skri, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Muiry, R, Parsons, et al |
Occup Med (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Are asylum seekers, refugees and foreign migrants considered in the COVID-19 vaccine discourse? |
Mukumbang, FC |
BMJ Global Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Biblical studies, COVID-19, and our response to growing inequality |
Nam, RS |
Journal of Biblical Literature |
Commentary/Editorial| Commentaire/Éditorial |
|
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Multisystemic inflammatory syndrome in children with COVID-19: a rheumatology perspective |
Naranjo Arango, YA, Farfán Cortés, et al |
Revista Colombiana de Reumatologia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ngatchou, W, Temgoua, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Effect of steroids on Covid-19 mortality risk: a Bayesian interpretation |
Nguyen, TV, Frost, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid 19 pandemic, status of clinical trials in africa on may 2020: Need to reinforce |
Nkeck, JR, Ndoadoumgue, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Human induced pluripotent stem cells as a tool for disease modeling and drug screening for
covid-19 |
Nolasco, P, Borsoi, et al |
Genetics and Molecular Biology |
Commentary/Editorial| Commentaire/Éditorial |
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Novack, Garyd |
Ocul Surf |
Commentary/Editorial| Commentaire/Éditorial |
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|
Response to COVID-19 in a large academic Centre in South Africa |
Ntusi, NAB |
Eur Heart J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Designing PISA-like mathematics problem in covid-19 pandemic (PISAComat) |
Nusantara, DS, Zulkardi, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sense and sensibility: an Irish dermatology department in the era of COVID-19 |
O'Connor, C, O'Connell, et al |
Clin Exp Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Medical Students' Corner: Barriers to Communication During the COVID-19 Pandemic |
Ogunbiyi, MO, Obiri-Darko, et al |
JMIR Med Educ |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ogundele, OA |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
How covid-19 pandemic is changing the africa’s elaborate burial rites, mourning and grieving |
Omonisi, AE |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pregnant womenʼs concerns and
antenatal care during covid-19 lock-down of the danish society |
Overbeck, G, Graungaard, et al |
Danish Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Padmanabhan, S |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Paquot, N, Radermecker, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Patel, P, Adebisi, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Urgent need to develop evidence-based COVID-19 recommendations for primary schools |
Patel, S, Epalza Ibarrondo, et al |
Arch Dis Child |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pattini, S, Malizia, et al |
Pediatric Allergy and Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Recent Advances in Selective Image Encryption and its Indispensability due to COVID-19 |
Paul, Aditya Jyoti |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pedrotti, G, Colombo, et al |
Crit Care |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pei, C, Ou, et al |
Aerosol and Air Quality Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Perazzolo, S, Zhu, et al |
J Pharm Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Coagulopathies, thrombotic risk and anticoagulation in COVID-19 |
Peters, P, Sprynger, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Petrie, JamesI, Masel, et al |
medRxiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Non-communicable Diseases and COVID-19; a double-edged sword A Special Communication from IRAN |
Peykari, N, Eybpoosh, et al |
Journal of Diabetes and Metabolic Disorders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Phuong, NT |
Journal of Law, Religion and State |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Risk Society and Science Education: Lessons from the Covid-19 Pandemic |
Pietrocola, M, Rodrigues, et al |
Science and Education |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The impact of the COVID-19 pandemic on the psychological health of healthcare workers |
Pitchot, W |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ponte, C |
Soins Aides - Soignantes |
Commentary/Editorial| Commentaire/Éditorial |
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Aerosol generation by respiratory support of neonates may be low |
Poorisrisak, P, Bivolarova, et al |
Acta Paediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Prager, KM, Dagi Glass, et al |
Am J Ophthalmol |
Commentary/Editorial| Commentaire/Éditorial |
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|
|
Ramle, MR, Mohamad, et al |
AlBayan |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rasiah, R, Kaur, et al |
Applied System Innovation |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ray, PS |
J Assoc Physicians India |
Commentary/Editorial| Commentaire/Éditorial |
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Resco de Dios, V |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
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Résimont, G, Dubois, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: GPs have "stepped up" in time of national crisis, says profession's leader |
Rimmer, A |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Possible impact of COVID-19 on gastric cancer surgery in Italy |
Rosa, F, Alfieri, et al |
Minerva chirurgica |
Commentary/Editorial| Commentaire/Éditorial |
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Rosenberg, J |
Ugeskrift for laeger |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7685945; Histologic Confounding Findings in Coronavirus disease 2019 (COVID-19) Pathology |
Rossi, G, Caruso, et al |
J Thorac Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
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Rukti Tanaya, D, Ekyawan, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
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Prenatal education of personal human development in COVID-19 pandemic |
Sadri, M, Yuliandari, et al |
International Journal of Pharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Salvalaggio, PR, Ferreira, et al |
Transpl Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 and its relationship with legal science from mexico’s perspective |
Sánchez Sánchez, A |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Specialized proresolving mediators in infection and lung injury |
Sandhaus, S, Swick, et al |
Biofactors |
Commentary/Editorial| Commentaire/Éditorial |
|
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JAK-STAT pathway inhibition and their implications in COVID-19 therapy |
Satarker, S, Tom, et al |
Postgrad Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Role of physical and rehabilitation medicine in the aftermath of SARS-CoV-2 disease |
Sauvant, C, Bodet, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Individualism will not save us: Personal liberty vs. community care in the time of COVID-19 |
Sayre, D |
Drama Therapy Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Scerri, M, Grech, et al |
Early human development |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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The Spanish flu, COVID-19 and Malta's reactions: Contrasts and similarities |
Scerri, M, Grech, et al |
Early human development |
Commentary/Editorial| Commentaire/Éditorial |
|
|
SARS-CoV-2 and COVID-19: not at the end of doubts, questions and controversies |
Scheen, AJ |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pharmacological therapies against COVID-19 : state of the art, between hopes and disappointments |
Scheen, AJ, Moutschen, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Vaccine-induced protection in aging adults and pandemic response |
Schenkelberg, T |
Biochemical and biophysical research communications |
Commentary/Editorial| Commentaire/Éditorial |
|
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Schudy, A, Żurek, et al |
Frontiers in Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Seron, MA, Strazzi-Sahyon, et al |
Brazilian dental journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sharma, D, Subramaniam, et al |
Indian Journal of Thoracic and Cardiovascular Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Sharun, K |
International Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Hotel industry performance in 2019-2020, COVID-19 impact, and the JHFM index |
Sheel, A |
Journal of Hospitality Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
|
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Jiangnan Shipyard overcomes
virus challenge to complete gas carrier |
Shipyard, J |
Naval Architect |
Commentary/Editorial| Commentaire/Éditorial |
|
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Shu, H, Wang, et al |
Virologica Sinica |
Commentary/Editorial| Commentaire/Éditorial |
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Digging the rabbit hole, COVID-19 edition: anti-vaccine themes and the discourse around COVID-19 |
Smith, TC, Reiss, et al |
Microbes and Infection |
Commentary/Editorial| Commentaire/Éditorial |
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Soule, EK, Kheradmand, et al |
Prev Med Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Viewpoint: COVID-19 and seed security response now and beyond |
Sperling, L, Louwaars, et al |
Food Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19: Advances in diagnostic tools, treatment strategies, and vaccine development |
Sreepadmanabh, M, Sahu, et al |
Journal of Biosciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The medium is the message: Τhe transformation of drama therapy practice during covid-19 |
Stavrou, D |
Drama Therapy Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sukamto, A, Panca Parulian, et al |
Journal of Law, Religion and State |
Commentary/Editorial| Commentaire/Éditorial |
|
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PMC7689644; The effects of containment measures in the Italian outbreak of COVID-19 |
Supino, M, d'Onofrio, et al |
BMC Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Susskind, D, Vines, et al |
Oxford Review of Economic Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Swaminathan, N, Jiandani, et al |
J Assoc Physicians India |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Tan, A, Jones, et al |
Int J Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Controversies in the use of new bone-modifying therapies in multiple myeloma |
Terpos, E, Ntanasis-Stathopoulos, et al |
Br J Haematol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7476900; Melatonin: a fertility-friendly anti-coronavirus agent |
Tesarik, J |
Reprod Biomed Online |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Aerosol Barriers in Pediatric Anesthesiology: clinical data supports FDA caution |
Tg Tighe, N, McClain, et al |
Paediatr Anaesth |
Commentary/Editorial| Commentaire/Éditorial |
|
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Cardiac intensive care unit during the coronavirus disease 2019 surge |
Thomas, B, Hassan, et al |
Am Heart J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
2020 vision: What happens next in education technology research in Australia |
Thompson, K, Lodge, et al |
Australasian Journal of Educational Technology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Tieri, L |
Diabetes research and clinical practice |
Commentary/Editorial| Commentaire/Éditorial |
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Tokmakov, MA |
|
Commentary/Editorial| Commentaire/Éditorial |
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“I really didn't want to come in”: The unseen effects of COVID-19 on children |
Toto, RL, Fesnak, et al |
Journal of Clinical Outcomes Management |
Commentary/Editorial| Commentaire/Éditorial |
|
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What impact of air pollution in pediatric respiratory allergic diseases |
Traina, G, Barbalace, et al |
Pediatric Allergy and Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tregoning, J |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Trottier, DG, Rodriguez-Perez, et al |
Drama Therapy Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7366095; Body temperature and host species preferences of SARS-CoV-2 |
Uzoigwe, CE |
Clin Microbiol Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Renin-angiotensin-aldosterone system : brief history and questions related to the COVID-19 pandemic |
Valdes-Socin, H, Jouret, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
|
|
van Gorp, M, Maurice-Stam, et al |
Pediatr Blood Cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Vandenbosch, K, Lasri, et al |
Revue medicale de Liege |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7691955; Can COVID-19 pandemic boost the epidemic of neurodegenerative diseases? |
Verkhratsky, A, Li, et al |
Biol Direct |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Verplanken, B, Marks, et al |
Journal of Environmental Psychology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Digitalization of the Labor Market in the Fourth Industrial Revolution |
Vladimirov, IS, Kamchatova, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Von Garnier, C, Soccal, et al |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Educators enacting online learning support roles in remote educational experiences |
Wardrip, PS |
Educational Technology Research and Development |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Changes in medical scientific publication associated with the COVID-19 pandemic |
Whitmore, KA, Laupland, et al |
Med J Aust |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Widyawati, F, Lon, et al |
Journal of Law, Religion and State |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Brassica box food products as a healthy local food innovation in the Covid-19 pandemic period |
Wijaya, H, Rouw, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Institutional versus home isolation to curb the COVID-19 outbreak – Authors' reply |
Wilder-Smith, A, Cook, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Non-shef2 model related containment and control measures against covid-19 in Africa |
Wirsiy, FS, Nkfusai, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rhinovirus remains prevalent in school teenagers during fight against COVID-19 pandemic |
Wu, D, Lu, et al |
Immun Inflamm Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Could SARS-CoV-2-induced lung injury be attenuated by vitamin D? |
Xiao, D, Li, et al |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Yang, M, Lai, et al |
Cell Death Discov |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
You, Z |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zhao, Y, Liang, et al |
Clin Microbiol Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7687364; Reply to "Novaferon, Treatment in COVID-19 Patients" |
Zheng, F, Zhou, et al |
Int J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Fatigue as long-term consequence of ARDS in COVID-19 patients |
Zuin, M, Rigatelli, et al |
Anaesth Crit Care Pain Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nat Nanotechnol |
Commentary/Editorial| Commentaire/Éditorial |
|
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PMC7694580; Author Correction: Modeling COVID-19 scenarios for the United States |
|
Nat Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Journal of pediatric ophthalmology and strabismus |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Open Heart |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Morbidity and Mortality Weekly Report |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
JAMA Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Urologia internationalis |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
5th International Conference
on Energy, Environmental and Information System, ICENIS 2020 |
|
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Commentary/Editorial| Commentaire/Éditorial |
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2nd International Seminar
on Applied Mathematics and Mathematics Education, ISAMME 2020 |
|
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Commentary/Editorial| Commentaire/Éditorial |
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Hypertension |
Commentary/Editorial| Commentaire/Éditorial |
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6th International Conference
on Technologies and Innovation, CITI 2020 |
|
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Commentary/Editorial| Commentaire/Éditorial |
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6th Joint International Conference
on Serious Games, JCSG 2020 |
|
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Commentary/Editorial| Commentaire/Éditorial |
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Commentary/Editorial| Commentaire/Éditorial |
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Commentary/Editorial| Commentaire/Éditorial |
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3rd International
Conference on Applied Informatics, ICAI 2020 |
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Commentary/Editorial| Commentaire/Éditorial |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.*
Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.
Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers.
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Séquelles à long terme:
Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.
Santé mentale:
Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées
à la pandémie.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives