Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-11-19

Good afternoon,

There are 349 citations in today’s scan. 229 were considered primary research or review literature.

Highlights today include

CANADA

· Fisman and Tuite hypothesized that differential ICU burden in Ontario might be explained by increased testing volumes, as well as the shift in mean case age from older to younger. Their model reproduced observed ICU admission volumes, and demonstrated good preliminary predictive validity. Furthermore, when admissions were used in combination with ICU length of stay, the modeled estimates demonstrated excellent convergent validity with ICU occupancy data reported by the Canadian Institute for Health Information.

PUBLIC HEALTH INTERVENTION

· Lee et al adapted a previously published model using contact information from Shanghai to model school reopening under various conditions. We investigated different strategies by combining the contact patterns observed between different age groups during both baseline and “lockdown” periods. We find that reopening schools for all children would maintain a post-intervention R0 < 1 up to a baseline R0 of approximately 3.3 provided that daily contacts among children 10–19 years are reduced to 33% of baseline.

IMMUNOLOGY

· Sokal et al., We report here a longitudinal single-cell and repertoire profiling of the B cell response up to 6 months in mild and severe COVID-19 patients. Overall, these findings demonstrate that an antigen-driven activation persisted and matured up to 6 months after SARS-CoV-2 infection and may provide long-term protection.

EPIDEMIOLOGY

· Ramasamy, K., explores the current state of COVID-19 pandemic of India and the USA and understand how the COVID-19 spread is severe in India. He  forecasted cumulative cases would be 11642764 in the USA and India, it would be 12023517 approximately.

· Ladhani et al measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates (SAR). Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P<0.001): 20/21 (95.2%) children were seropositive in 9 families and none of 23 children in 12 other families.  

SEROPREVALENCE

· Martin et al. conducted a cross-sectional surveillance examining SARS-CoV-2 seroprevalence amongst staff at a UK hospital. 10.8% hospital staff members were seropositive. Compared to White staff (seroprevalence 9.1%), seroprevalence was higher in South Asian (12.3%) and Black (21.2%) staff. The occupations and department with the highest seroprevalence were nurses/healthcare assistants (13.7%) and the Emergency Department (ED)/Acute Medicine (17.5%), respectively. Seroprevalence decreased with seniority in medical/nursing practitioners.

VACCINE RESEARCH

· Solforosi et al., Here we assessed the immunogenicity of one- and two-dose Ad26.COV2.S vaccine regimens in adult and aged non-human primates (NHP).  A second vaccine dose, administered 8 weeks post the first immunization, induced a significant increase in antigen-specific binding and neutralizing antibody responses in both adult and aged animals as compared to a single dose.

DIAGNOSTICS

· Masia et al. report nasopharyngeal Panbio COVID-19 antigen test performed at point-of-care is highly sensitive in symptomatic patients, particularly with Ct<30 and older age. The test to be useful to identify asymptomatic patients with lower Ct values and therefore with contagious risk.

Regards,

Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley Otten, Drew Greydanus, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark, Catherine Card, Ruey Su, Paul McLaren

Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news

Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance, Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI, Réponse des soins de santé, Immunologie, économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux

PUBLICATIONS	AUTHORS / AUTEURS	SOURCE	FOCI / DOMAINE	SUMMARY / SOMMAIRE
Measuring the Impact of COVID-19 Pandemic Fear on Stress, Anxiety, and Depression among General Public in Sindh	Ahmed Soomro,  Mansoor,  Memon, et al	SSRN- Lancet prepublication	Mental Health | santé mentale	The study has examined the level of stress, anxiety, and depression among the general public due to coronavirus. The data was collected by using a structured questionnaire from the public of Sindh province, Pakistan in March and April. A total number of 462 responses were received through an online survey. The research findings revealed that there is a significant relationship between COVID-19 and stress, anxiety and depression.
Estimating, Monitoring, and Forecasting the Covid-19 Epidemics: A Spatio-Temporal Approach Applied to NYC Data	Albani,  ViniciusVL,  Velho, et al	arXiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	We propose an SEIR-type meta-population model to simulate and monitor the Covid-19 epidemic evolution. The basic model consists of seven compartments, namely susceptible (S), exposed (E), three infective classes, recovered (R), and deceased (D). We define these compartments for n age and gender groups in m different spatial locations. So, the resulting model has, for each age group, gender, and place, all epidemiological classes. The mixing between them is accomplished by means of time-dependent infection rate matrices. The model is calibrated with the curve of daily new infections in New York City and its boroughs, including census data, and the proportions of infections, hospitalizations, and deaths for each age range. We end up with a model that matches the reported curves and predicts accurately infection information for different places and age classes.
PMC7662076; Efficient Artificial Intelligence Forecasting Models for COVID-19 Outbreak in Russia and Brazil	Al-Qaness,  M,  Saba, et al	Process Saf Environ Prot	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	In this paper, we propose a new short term forecasting model using an enhanced version of the Adaptive Neuro-Fuzzy Inference System (ANFIS). An improved Marine Predators Algorithm (MPA), called Chaotic MPA (CMPA), is applied to enhance the ANFIS and to avoid its shortcomings. More so, we compared the proposed CMPA with three artificial intelligence-based models include the original ANFIS, and two modified versions of ANFIS model using both of the original Marine Predators Algorithm (MPA) and Particle Swarm Optimization (PSO). The forecasting accuracy of the models was compared using different statistical assessment criteria. CMPA significantly outperformed all other investigated models.
Modelling the structural and reactivity landscapes of tucatinib with special reference to its wavefunction-dependent properties and screening for potential antiviral activity	Alsalme,  A,  Pooventhiran, et al	J Mol Model	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Tucatinib is recently developed and approved as a potential medicine to fight HER-2 type breast cancer. In this manuscript, we present the gross structural features of this compound and its reactivity and wave function properties using computational simulations. Density functional theory was used to optimise the ground state geometry of the molecule and molecular docking was used to predict biological activity. Information entropy calculations show that the compound is inherently stable. Docking with COVID-19 proteins show docking score of - 9.42, - 8.93, - 8.45 and - 8.32 kcal/mol respectively indicating high interaction between the drug and proteins. Hence, this is an ideal candidate to study repurposing of existing drugs to combat the pandemic.
PMC7436379; Evaluation of the prothrombin fragment 1.2 in patients with coronavirus disease 2019 (COVID-19)	Al-Samkari,  H,  Song, et al	Am J Hematol	Clinical data| Données cliniques	We studied hospitalized adults with COVID-19 and prothrombin fragment 1.2 (PF1.2) measurements performed at any time during hospitalization. We evaluated the relationship between PF1.2 and synchronously measured D-dimer. A total of 115 patients were included 110 (95.7%) critically ill]. Both PF1.2 and D-dimer were moderately positively correlated (r = 0.542, P 523 pmol/L: 69.2% sensitivity, 67.7% specificity; >924 pmol/L: 37.9% sensitivity, 87.8% specificity). In multivariable analysis, a PF1.2 >500 pmol/L was significantly associated with VTE adjusted odds ratio (OR) 4.26, 95% CI, 1.12-16.21, P = .034] and any thrombotic manifestation (adjusted OR 3.85, 95% CI, 1.39-10.65, P = .010); conversely, synchronously measured D-dimer was not significantly associated with thrombosis. 90.6% of patients with a non-elevated PF1.2 result did not develop VTE. So, PF1.2 may be a useful assay, and potentially more discriminant than D-dimer, in identifying thrombotic manifestations in hospitalized patients with COVID-19.
Cross-Comparison of a Chemiluminescent Platform and a Commercial Receptor Binding Domain-Based ELISA for Detecting SARS-CoV-2 IgG	Antoine-Reid,  T,  Malone, et al	The journal of applied laboratory medicine	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	We evaluated the performance of the Abbott Architect IgG assay vs. the GenScript SARS-CoV-2 Spike S1-RBD IgG ELISA, a research-use-only methodology that would require local validation to meet CLIA and FDA requirements. The Architect demonstrated 100% specificity for serum (230/230; 95% CI, 98.4%–100%) and 98.8% for plasma (235/238; 95% CI, 96.4%–99.6%) while ELISA sensitivity was 85.7% (18/21; 95% CI, 65.4%–95.0%) for serum and 93.5% (43/46; 95% CI, 82.5%–97.7%) for plasma (varying based on assigned positivity threshold).
ceRNA analysis of SARS-CoV-2	Arancio,  W	Arch Virol	Coronavirology| Coronavirologie	Viral RNAs can perturb the miRNA regulatory network, competing with host RNAs as part of their infective process. An in silico competing endogenous RNA (ceRNA) analysis has been carried on SARS-CoV-2. The results suggest that, in humans, the decrease of microRNA activity caused by viral RNAs can lead to a perturbation of vesicle trafficking and the inflammatory response, in particular by enhancing KLF10 activity. The results suggest also that, during the study of the mechanics of viral infections, it could be of general interest to investigate the competition of viral RNA with cellular transcripts for shared microRNAs.
CovidCounties is an interactive real time tracker of the COVID19 pandemic at the level of US counties	Arneson,  D,  Elliott, et al	Sci Data	Epidemiology| Épidémiologie	Here we report the development of CovidCounties.org, an interactive web application that depicts daily disease trends at the level of US counties using time series plots and maps. This application is accompanied by a manually curated dataset that catalogs all major public policy actions made at the state-level, as well as technical validation of the primary data. Finally, the underlying code for the site is also provided as open source, enabling others to validate and learn from this work.
Comparison of different anticoagulation strategies for renal replacement therapy in critically ill patients with COVID-19: a cohort study	Arnold,  F,  Westermann, et al	BMC Nephrol	Clinical data| Données cliniques	This study investigated whether alternative anticoagulation strategies for renal replacement therapy (RRT) during COVID-19 are superior to administration of unfractionated heparin (UFH).  In patients receiving continuous veno-venous hemodialysis (CVVHD), mean treatment time in the UFH group was 21.3 h ( SEM: ±5.6 h), in the citrate group 45.6 h (SEM: ±2.7 h). Citrate anticoagulation significantly prolonged treatment times by 24.4 h (P = .001). In patients receiving sustained low-efficiency daily dialysis (SLEDD), mean treatment time with UFH was 8.1 h (SEM: ±1.3 h), with argatroban 8.0 h (SEM: ±0.9 h), and with low molecular weight heparin (LMWH) 11.8 h (SEM: ±0.5 h). LMWH significantly prolonged treatment times by 3.7 h (P = .008) and 3.8 h (P = .002), respectively. UFH fails to prevent early clotting events in the dialysis circuit during COVID-19. For patients, who do not require effective systemic anticoagulation, regional citrate dialysis is the most effective strategy. For patients, who require effective systemic anticoagulation, the usage of LMWH results in the longest circuit life spans.
Tracking R of COVID-19: A New Real-Time Estimation Using the Kalman Filter	Arroyo Marioli,  Francisco,  Bullano, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	This study developed a new method for estimating the effective reproduction number of an infectious disease (R) and applied it to track the dynamics of COVID-19. The method is based on the fact that in the SIR model, R is linearly related to the growth rate of the number of infected individuals. This time-varying growth rate is estimated using the Kalman filter from data on new cases. The method is easy to implement in standard statistical software, and it performs well even when the number of infected individuals is imperfectly measured, or the infection does not follow the SIR model. The estimates of R for COVID-19 for 124 countries across the world are provided in an interactive \href{https://bit.ly/Rtlive}{online dashboard}, and they are used to assess the effectiveness of non-pharmaceutical interventions in a sample of 14 European countries.
PMC7667906; Symptoms of Anxiety, Depression, and Peritraumatic Dissociation in Critical Care Clinicians Managing Patients with COVID-19. A Cross-Sectional Study	Azoulay,  E,  Cariou, et al	Am J Respir Crit Care Med	Mental Health | santé mentale	This cross-sectional study assessed the prevalence of symptoms of anxiety, depression, and peritraumatic dissociation in HCPs. The prevalence of symptoms of anxiety, depression, and peritraumatic dissociation was 50.4%, 30.4%, and 32%, respectively, with the highest rates in nurses. By multivariable analysis, male sex was independently associated with lower prevalence of symptoms of anxiety, depression, and peritraumatic dissociation (OR 0.58 95% CI, 0.42-0.79], 0.57 95% CI, 0.39-0.82], and 0.49 95% CI, 0.34-0.72], respectively). HCPs working in non-university-affiliated hospitals and nursing assistants were at high risk of symptoms of anxiety and peritraumatic dissociation. Importantly, identified the following six modifiable determinants of symptoms of mental health disorders: fear of being infected, inability to rest, inability to care for family, struggling with difficult emotions, regret about the restrictions in visitation policies, and witnessing hasty end-of-life decisions.
Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (m(pro)): a molecular docking, molecular dynamics and structure-activity relationship studies	Badavath,  VN,  Kumar, et al	J Biomol Struct Dyn	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	This article reports a computer-aided drug design (CADD) approach for the screening of 118 compounds with 16 distinct heterocyclic moieties in comparison with 5 natural products and 7 repurposed drugs. Molecular docking analysis against M(pro) protein were performed finding isatin linked with a oxidiazoles (A2 and A4) derivatives to have the best docking scores of -11.22 kcal/mol and -11.15 kcal/mol respectively. Structure-activity relationship studies showed a good comparison with a known active M(pro) inhibitor and repurposed drug ebselen with an IC(50) value of -0.67 μM. Molecular Dynamics (MD) simulations for 50 ns were performed for A2 and A4 supporting the stability of the two compounds within the binding pocket, largely at the S1, S2 and S4 domains with high binding energy suggesting their suitability as potential inhibitors of M(pro) for SARS-CoV-2.
SARS-CoV-2 Seroprevalence Study in Pimpri-Chinchwad, Maharashtra, India Coinciding with Falling Trend – Do the Results Suggest Imminent Herd Immunity?	Banerjee,  Amitav,  Gaikwad, et al	SSRN- Lancet prepublication	Epidemiology| Épidémiologie Immunology | Immunologie	A population based seroprevalence study was conducted for IgG antibodies for SARS-CoV-2 among 5000 residents in Pimpri-Chinchwad township . The overall seropositivity for IgG antibodies was 34.04% (95% confidence interval 31.3% to 36.8%). Slum dwellers had positivity rate of 40.9% (95% confidence interval 37.0% to 44.7%), those in tenements had positivity of 41.2% (95% confidence interval 37.7% to 44.8%) and more affluent people living in housing societies had positivity of 29.8% (95% confidence interval 25.8% to 33.8%). The study indicates that a considerable proportion of the population had encountered the novel coronavirus approaching partial, if not complete, herd immunity, which may partly explain the declining trend in spite of easing of lockdown restrictions.
Prevalence of SARS-CoV-2 infection in previously undiagnosed health care workers in New Jersey, at the onset of the U.S. COVID-19 pandemic	Barrett,  ES,  Horton, et al	BMC Infect Dis	Epidemiology| Épidémiologie	This prospective cohort study of HCW (n = 546) and non-healthcare workers (NHCW; n = 283) with no known prior SARS-CoV-2 infection was conducted to examine SARS-CoV-2 infection status (as determined by presence of SARS-CoV-2 RNA in oropharyngeal swabs). At baseline, 41 (5.0%) of the participants tested positive for SARS-CoV-2 infection, of whom 14 (34.2%) reported symptoms. The prevalence of SARS-CoV-2 infection was higher among HCW (7.3%) than in NHCW (0.4%), representing a 7.0% greater absolute risk (95% confidence interval for risk difference 4.7, 9.3%). The majority of infected HCW (62.5%) were nurses. Positive tests increased across the two weeks of cohort recruitment in line with rising confirmed cases in the hospitals and surrounding counties.
PMC7657101; Civic capital and social distancing during the Covid-19 pandemic(☆)	Barrios,  JM,  Benmelech, et al	J Public Econ	Public Health response| Interventions de santé publique	Using mobile phone and survey data, this study show that during the early phases of COVID-19, voluntary social distancing was greater in areas with higher civic capital and amongst individuals exhibiting a higher sense of civic duty. This effect is robust to including controls for political ideology, income, age, education, and other local-level characteristics.  Also show that after U.S. states began re-opening, high civic capital counties maintained a more sustained level of social distancing, while low civic capital counties did not. The U.S. individuals reported a higher tendency to use protective face masks in high civic capital counties.
Cell differentiation and aging accompanied by depletion of the ACE2 protein	Bártová,  E,  Legartová, et al	Aging (Albany NY)	Clinical data| Données cliniques Animal model | Modèle animal	This  research studied the cell surface receptor of the SARS-CoV-2 virus ACE2 and its levels changed during cell differentiation and aging and varied in distinct cell types. Observed ACE2 depletion in the aortas of aging female mice, similarly, the aging caused ACE2 decrease in the kidneys. Compared with that in the heart, brain and kidneys, the ACE2 level was the lowest in the mouse lungs. In mice exposed to nicotine, ACE2 was not changed in olfactory bulbs but in the lungs, ACE2 was upregulated in females and downregulated in males. These observations indicate the distinct gender-dependent properties of ACE2. Differentiation into enterocytes, and cardiomyocytes, caused ACE2 depletion. The cardiomyogenesis was accompanied by renin upregulation, delayed in HDAC1-depleted cells. In contrast, vitamin D2 decreased the renin level while ACE2 was upregulated. Together, the ACE2 level is high in non-differentiated cells. This protein is more abundant in the tissues of mouse embryos and young mice in comparison with older animals. Mostly, downregulation of ACE2 is accompanied by renin upregulation.
CovEMERALD: Assessing the feasibility and preliminary effectiveness of remotely delivered Eye Movement Desensitisation and Reprocessing following Covid-19 related critical illness: A structured summary of a study protocol for a randomised controlled trial	Bates,  A,  Rushbrook, et al	Trials	RCT	This paper presents a study protocol for a randomised controlled trial to determine the feasibility of delivering a protocolised, remote, online, Eye Movement Desensitisation and Reprocessing (EMDR) intervention, within 12-weeks of hospital discharge, for adult survivors of Covid-19 related critical illness. And to investigate whether remotely delivered EMDR can improve psychological outcome following Covid-19 related critical illness, specifically Post-Traumatic Stress Disorder (PTSD), anxiety and depression.
Clinical profile and predictors of in-hospital mortality among older patients admitted for COVID-19	Becerra-Muñoz,  VM,  Núñez-Gil, et al	Age Ageing	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study was a post-hoc analysis of the international, multicentre, "real-world" HOPE COVID-19 registry of all patients aged ≥65 years who were hospitalised for COVID-19 to look at all cause in-hospital mortality. 1,520 patients aged ≥65 years (60.3% male, median age of 76 IQR 71-83] years) were included. Comorbidities such as hypertension (69.2%), dyslipidemia (48.6%), cardiovascular diseases (any chronic heart disease in 38.4% and cerebrovascular disease in 12.5%), and chronic lung disease (25.3%) were prevalent, and 49.6% were on ACEI/ARBs. Patients aged 75 years and older suffered more in-hospital complications (respiratory failure, heart failure, renal failure, sepsis) and a significantly higher mortality (18.4 vs. 48.2%, P 1 (OR 8.31) to be independent predictors of mortality.  Patients aged ≥65 years hospitalised for COVID-19 had high rates of in-hospital complications and mortality, especially among patients 75 years or older.
PMC7451099; Responses to COVID-19 in five Latin American countries	Benítez,  MA,  Velasco, et al	Health Policy Technol	Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	This paper focuses on the first months of the pandemic in five Latin American countries: Brazil, Chile, Colombia, Ecuador and Peru. It analyses how the pre-pandemic context, and the government's responses to contain and mitigate the spread together with economic measures have affected the COVID-19 health outcomes. The countries were quick to implement stringent COVID-19 measures and incrementally scaled up their health systems capacity, although tracing and tracking have been poor. All five countries have experienced a large number of cases and deaths due to COVID-19. The analysis on the excess deaths also shows that the impact in deaths is far higher than the official numbers reported to date for some countries.
Estimating individual risks of COVID-19-associated hospitalization and death using publicly available data	Bhatia,  Rajiv,  Klausner, et al	medRxiv	Epidemiology| Épidémiologie	We describe a method to estimate individual risks of hospitalization and death attributable to non-household and household transmission of SARS-CoV-2 using available public data. Using the method, we estimate that risks for a 90-day period at the median daily summertime U.S. county confirmed COVID-19 case incidence of 10.8 per 100,000 and pre-pandemic contact rates range from 0.4 to 8.9 per 100,000 for the four deciles of age between 20 and 60 years. The corresponding 90-day period risk of hospitalization ranges from 13.7 to 69.2 per 100,000. Assuming a non-household secondary infection risk of 4% and pre-pandemic contact rates, the share of transmissions attributable to household settings ranges from 73% to 78%.
PMC7657089; The behaviour of infection, survival and testing effort variables of SARS-CoV-2: A theoretical modelling based on optimization technique	Bhattacharya,  S,  Paul, et al	Results Phys	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	The present study tries to illustrate the identification of infected under two frames like discrete and continuous set. The importance of effort for the identification under each process can be replaced by variables like testing. Thus, number test per day is the most significant variable to overcome the disease.
Mosaic RBD nanoparticles elicit neutralizing antibodies against SARS-CoV-2 and zoonotic coronaviruses	Bjorkman,  PamelaJ,  Cohen, et al	bioRxiv	Vaccine Research| Recherche sur les vaccins Immunology | Immunologie Animal model | Modèle animal	To evaluate immunization strategies, we made nanoparticles displaying the receptor-binding domain (RBD) of only SARS-CoV-2 (homotypic nanoparticles) or co-displaying the SARS-CoV-2 RBD along with RBDs from animal betacoronaviruses that represent threats to humans (mosaic nanoparticles; 4-8 distinct RBDs). Mice immunized with RBD-nanoparticles, but not soluble antigen, elicited cross-reactive antibody binding and neutralization responses, confirming increased immunogenicity from multimerization. A single immunization with mosaic-RBD-nanoparticles provides a potential strategy to simultaneously protect against SARS-CoV-2 and emerging zoonotic coronaviruses.
Prognostic factors and predictors of outcome in patients with COVID-19 and related pneumonia: a retrospective cohort study	Boari,  GEM,  Chiarini, et al	Biosci Rep	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim of the study was to assess simultaneously several potential predictors of outcome (co-morbidity, previous and in-hospital treatment, radiologic Brixia score) in patients with COVID-19. This retrospective cohort study included 258 consecutive patients with confirmed COVID-19. During hospitalization, 59 patients died, while 6 died after discharge. The following variables were demonstrated to be associated with a worse prognosis: Radiologic Brixia score higher than 8, presence at baseline of hypertension, diabetes, chronic obstructive pulmonary disease, heart disease, cancer, previous treatment with ACE-inhibitors or anti-platelet drugs. Anticoagulant treatment during hospital admission with enoxaparin at a dose higher than 4000 U per was associated to a better prognosis.
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters	Boudewijns,  R,  Thibaut, et al	Nat Commun	Immunology | Immunologie Animal model | Modèle animal	Here, we show that Syrian hamsters, in contrast to mice, are highly permissive to SARS-CoV-2 and develop bronchopneumonia and strong inflammatory responses in the lungs with neutrophil infiltration and edema, further confirmed as consolidations visualized by micro-CT alike in clinical practice. Moreover, we identify an exuberant innate immune response as key player in pathogenesis, in which STAT2 signaling plays a dual role, driving severe lung injury on the one hand, yet restricting systemic virus dissemination on the other. Our results reveal the importance of STAT2-dependent interferon responses in the pathogenesis and virus control during SARS-CoV-2 infection and may help rationalizing new strategies for the treatment of COVID-19 patients.
Acute Kidney Injury in a National Cohort of Hospitalized US Veterans with COVID-19	Bowe,  B,  Cai, et al	Clin J Am Soc Nephrol	Epidemiology| Épidémiologie Clinical data| Données cliniques	We aimed to describe rates and characterize predictors and health outcomes associated with AKI in a national cohort of US veterans hospitalized with COVID-19. AKI is common during hospitalization with COVID-19 and associated with higher risk of health care resource utilization and death. Nearly half of patients with AKI did not recover to baseline by discharge. Substantial geographic variation and temporal decline in rates and severity of AKI were observed.
Transmission of SARS-CoV-2 in domestic cats imposes a narrow bottleneck	Braun,  KatarinaM,  Moreno, et al	bioRxiv	Transmission Coronavirology| Coronavirologie zoonoses	Using domestic cats as a model, we show that SARS-CoV-2 consensus sequences remain largely unchanged over time within hosts, but dynamic sub-consensus diversity reveals processes of genetic drift and weak purifying selection. Transmission bottlenecks in this system appear narrow, with new infections being founded by fewer than ten viruses. We identify a notable variant at amino acid position 655 in Spike (H655Y) which arises rapidly in index cats and becomes fixed following transmission in two of three pairs, suggesting this site may be under positive selection in feline hosts. We speculate that narrow transmission bottlenecks and the lack of pervasive positive selection combine to constrain the pace of ongoing SARS-CoV-2 adaptive evolution in mammalian hosts.
A Randomised Trial of Covid-19 Transmission in Training Facilities	Bretthauer,  Michael	medRxiv	Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	We investigated SARS-CoV-2 virus transmission, Covid-19 and SARS-CoV-2 antibodies attributable to training facilities. We randomised members aged 18 to 64 without relevant comorbidities at five training facilities in Oslo, Norway, to access or no access to their facility. Eleven individuals in the training arm (0.8% of tested) and 27 in the no-training arm (2.4% of tested) tested positive for SARS-CoV-2 antibodies (p=0.001). Provided good hygiene and physical distancing measures, there was no increased transmission of SARS-CoV-2 at training facilities.
Clinical Profile of First 1000 COVID-19 Cases Admitted at Tertiary Care Hospitals and the Correlates of their Mortality: An Indian Experience	Budhiraja,  Sandeep,  Soni, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study aimed to describe the clinical profile and factors leading to increased mortality in COVID-19 patients admitted to a group of hospitals in India. Male patients above the age of 60 and with co-morbidities faced the highest rates of mortality. They should be admitted to the hospital in early stage of the disease and given aggressive treatment to help reduce the morbidity and mortality associated with COVID-19.
Intraoperative aerosol box use: does an educational visual aid reduce contamination?	Burnett,  GW,  Zhou, et al	Korean J Anesthesiol	Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)	We evaluated intraoperative contamination and aerosol box decontamination and the impact of a preoperative educational visual aid. The use of a visual aid significantly decreased intraoperative contamination and improved box cleaning. Despite these findings, a potentially clinically significant amount of viral exposure may exist. Thorough evaluation of the risks and benefits of the aerosol box should be completed prior to use.
PMC7644259 personal relationships that could have appeared to influence the work reported in this paper; Epidemic model on a network: Analysis and applications to COVID-19	Bustamante-Castañeda,  F,  Caputo, et al	Physica A	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	We analyze an epidemic model on a network consisting of susceptible-infected-recovered equations at the nodes coupled by diffusion using a graph Laplacian. We introduce an epidemic criterion and examine different isolation strategies: we prove that it is most effective to isolate a node of highest degree. The model is also useful to evaluate deconfinement scenarios and prevent a so-called second wave. The model has few parameters enabling fitting to the data and the essential ingredient of importation of infected; these features are particularly important for the current COVID-19 epidemic.
[Survey data as a way to estimate the prevalence of COVID-19. A pilot study in the city of Madrid.]	Carabaña Morales,  J	Rev Esp Salud Publica	Epidemiology| Épidémiologie	Its goal was to evaluate the potential of interviewing such type of samples in order to assess the incidence and prevalence of epidemics as COVID-19. RESULTS: Prevalence for individuals. On April/3/20, 10,9% of people 18 years and older living in Madrid reported symptoms compatible with COVID19 (SCC19). Occurrence of SCC19 was similar for both sexes, being respectively above and below the mean for the 40-49 (18,9%) and for the >69 (4%) age groups, showing no relation with household size, but being associated with economic activity (19% among working population) and, even more strongly, with the fact of living with symptomatic co-residents (52%).
PMC7598530; Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells	Carpinteiro,  A,  Edwards, et al	Cell Rep Med	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Here, we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline or genetic downregulation of the enzyme prevents infection of cultured cells or freshy isolated human nasal epithelial cells with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or vesicular stomatitis virus (VSV) pseudoviral particles (pp-VSV) presenting SARS-CoV-2 spike protein (pp-VSV-SARS-CoV-2 spike), a bona fide system mimicking SARS-CoV-2 infection.
Prevalence and risk factors for lung involvement on low-dose chest CT (LDCT) in a paucisymptomatic population of 247 patients affected by COVID-19	Castelli,  M,  Maurin, et al	Insights Imaging	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim of this study was to describe the prevalence and risk factors for lung involvement in 247 patients with a visual score and assess the prevalence of incidental findings. METHODS: For 12 days in March 2020, 250 patients with RT-PCR positive tests and who underwent LDCT were prospectively included. The prevalence of lung involvement was 54% in a predominantly paucisymptomatic population. Age ≥ 55 years and diabetes were risk factors for significant parenchymal lung involvement. Rhinitis and anosmia were protective against LDCT abnormalities.
Implementation of a medical student-run telemedicine program for medications for opioid use disorder during the COVID-19 pandemic	Castillo,  M,  Conte, et al	Harm Reduct J	Healthcare Response | Réponse des soins de santé	We describe development and implementation of a medical student-run telemedicine clinic through an academic medical center-operated syringe services program. RESULTS: Over the first 9 weeks in operation, 31 appointments were requested, and 22 initial telehealth appointments were completed by a team of students and attending physicians. Fifteen appointments were for MOUD and 7 for other health issues. All patients seeking MOUD were prescribed buprenorphine and 12/15 successfully picked up medications from the pharmacy.  TeleMOUD is feasible and successful in providing people who inject drugs with low barrier access to life-saving MOUD during the COVID-19 pandemic.
Characteristics and well-being of urban informal home care providers during COVID-19 pandemic: a population-based study	Chan,  EY,  Lo, et al	BMJ Open	Mental Health | santé mentale Public Health response| Interventions de santé publique	A random, cross-sectional, population-based, RDD, telephone survey study was conducted to examine patterns of home care, characteristics of informal home care providers and the challenges experienced by these care providers during this pandemic. RESULTS: Of the respondents, 25.1% of 765 provided informal home care during the studied COVID-19 pandemic period. Among the informal home care providers, 18.4% of respondents took leave from school/work during the epidemic to provide care for the sick, fragile elderly and small children. Care providers tended to be younger aged, female and housewives. Approximately half of care providers reported additional mental strain and 37.2% reported of challenges in daily living during epidemic.
Predicting the local COVID-19 outbreak around the world with meteorological conditions: a model-based qualitative study	Chen,  B,  Liang, et al	BMJ Open	Epidemiology| Épidémiologie	This study aims to investigate the relationship between daily weather and transmission rate of SARS-CoV-2, and to develop a generalised model for future prediction of the COVID-19 spreading rate for a certain area with meteorological factors. RESULTS: Significant correlation of the daily new confirmed case count with the weather 3 to 7 days ago were found. SARS-CoV-2 is easy to spread under weather conditions of average temperature at 5 to 15°C, relative humidity at 70% to 80%, wind speed at 1.5 to 4.5 m/s and air visibility less than 10 statute miles.
Characteristics of online medical care consultation for pregnant women during the COVID-19 outbreak: cross-sectional study	Chen,  M,  Liu, et al	BMJ Open	Healthcare Response | Réponse des soins de santé	This study described the needs of pregnant women and the contents of online obstetric consultation in representative areas with various severity of the epidemic in China. RESULTS: The distribution of the amount of online consultations was significantly different not only in different areas (p<0.001) but also in different trimesters (p<0.001). A total of 957 participants completed the satisfaction part of the survey. In this study, 77.95% of the participants used e-health for the first time, and 94.63% of the participants were completely or mostly satisfied with the online consultations.
SARS-CoV-2 Infected Cardiomyocytes Recruit Monocytes by Secreting CCL2	Chen,  Shuibing,  Yang, et al	Research Square prepub	Animal model | Modèle animal	In order to study the cause of myocardial pathology in COVID-19 patients, we used a hamster model to determine whether following infection SARS-CoV-2, the causative agent of COVID-19, can be detected in heart tissues. Here, we clearly demonstrate that viral RNA and nucleocapsid protein is present in cardiomyocytes in the hearts of infected hamsters.  Moreover, we show that both human pluripotent stem cell-derived cardiomyocytes (hPSC-derived CMs) and adult cardiomyocytes (CMs) can be infected by SARS-CoV-2 and that CCL2 is secreted upon SARS-CoV-2 infection, leading to monocyte recruitment. Increased CCL2 expression and macrophage infiltration was also observed in the hearts of infected hamsters.
Notes from the Field: Effectiveness of Prevention and Control Measures for Imported COVID-19 in Guangming District of Shenzhen	Chen,  X,  Wang, et al	Eval Health Prof	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	We implemented a surveillance and screening strategy that included early detection of laboratory-confirmed COVID-19 cases and people who were exposed to the disease in Guangming District of Shenzhen. From January 23 to March 13, 2020, we found 12 suspected cases, and 11 were confirmed as positive. After February 14, when the last case was confirmed, there were no newly confirmed cases for 28 consecutive days under the strict outbreak control.
Hospitalized Patients With COVID-19 and Human Immunodeficiency Virus: A Case Series	Childs,  K,  Post, et al	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America	Clinical data| Données cliniques	We report the clinical characteristics of 18 people with human immunodeficiency virus (PWH) who were hospitalized with confirmed COVID-19 including the proportion who reached a composite endpoint of death, requiring mechanical ventilation or intensive treatment unit admission.
The case of a 69-year-old man with COVID-19 and encephalopathy	Cline,  TE,  Sangha, et al	Ann Clin Transl Neurol	Clinical data| Données cliniques	A 69-year-old man positive for COVID-19 with uncontrolled type 2 diabetes presented to an outside hospital with altered mental status. He progressed from being argumentative to encephalopathic and agitated by the evening with urinary frequency, urinary urgency, nausea, and vomiting.
The Impact of COVID-19 on Service Provision for Emergency Department Patients Post-Opioid Overdose: A Field Report	Collins,  AB,  Beaudoin, et al	J Addict Med	Healthcare Response | Réponse des soins de santé	We describe a rapid environmental assessment with senior emergency department (ED) practitioners in Rhode Island to understand how COVID-related procedural changes impact the provision of post-overdose care in ED. RESULTS: COVID-related policy changes challenged the provision of services to PWUD in the ED, and extended challenges in connecting people with OUD to services in the community. Specifically, challenges included transitions to telehealth modalities, required COVID tests for treatment services, and gaps in community resources.
Immunodominant regions prediction of nucleocapsid protein for SARS-CoV-2 early diagnosis: a bioinformatics and immunoinformatics study	Dai,  Y,  Chen, et al	Pathog Glob Health	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology | Immunologie	Rapid and accurate detection along with timely isolation is the key to control the COVID-19 epidemic. Authors discuss nucleic acid test and antibody-detection. The final construct was built based on the bioinformatics analysis, which could help to develop an antigen-capture system for the early diagnosis of SARS-CoV-2.
COVID-19 Surveillance in a Primary Care Sentinel Network: In-Pandemic Development of an Application Ontology	de Lusignan,  S,  Liyanage, et al	JMIR Public Health Surveill	Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé	This study aimed to develop an application ontology for COVID-19 that can be deployed across the various use-case domains of the RCGP RSC research and surveillance activities. The underpinning structure of the ontological approach has coped with multiple clinical coding challenges.
SARS-CoV-2 Screening Among Symptom-Free Healthcare Workers	Demmer,  RyanT,  Ulrich, et al	medRxiv	Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé	A cross-sectional convenience sample of symptom-free HCWs from the metropolitan area surrounding Minneapolis and St. Paul, Minnesota were tested for COVID-19.  The point prevalence of SARS-CoV-2 infection was likely <1% in a convenience sample of symptom-free Minnesota healthcare workers.
Molecular docking studies, molecular dynamics and ADME/tox reveal therapeutic potentials of STOCK1N-69160 against papain-like protease of SARS-CoV-2	Elekofehinti,  OO,  Iwaloye, et al	Mol Divers	Therapeutics| Thérapeutique	This study was conducted to evaluate the efficacy of ~ 50,000 natural compounds retrieved from IBS database against COVID-19 PLpro using computer-aided drug design. The edge of the compound was further established by its stability in molecular dynamics (MD) simulation conducted for 30 ns employing GROMACS software.
Detection of SARS-CoV-2 antibodies is insufficient for the diagnosis of active or cured COVID-19	Escribano,  P,  Álvarez-Uría, et al	Sci Rep	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Authors assessed the performance of Abbott's SARS-CoV-2 IgG assay and the PanbioTM COVID-19 IgG/IgM rapid test device for the diagnosis of either active or cured COVID-19. They show that IgG detection alone is insufficient for the diagnosis of active or cured COVID-19.
A Multi-Factor Risk Model for Severe Covid-19, Vaccine Prioritization and Monitoring Based on a 16 Million Medicare Cohort	Experton,  Bettina,  Tetteh, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	Authors present an integrated multi-factor risk model for severe Covid-19 combining demographic and clinical data extracted from de-identified Medicare claims for a cohort of 16 million Medicare beneficiaries with over 900,000 Covid-19 cases, and socio-economic data at the county and zip code level from the CDC Social Vulnerability Index.
Inhibitory potential of repurposed drugs against the SARS-CoV-2 main protease: a computational-aided approach	Fadaka,  AO,  Aruleba, et al	J Biomol Struct Dyn	Therapeutics| Thérapeutique	This study investigated the inhibitory effects of Pradimicin A, Lamivudine, Plerixafor and Lopinavir against SARS-CoV-2 M(pro). Molecular dynamics confirmed that the ligands maintained their interaction with the protein with lower RMSD fluctuations over the trajectory period of 100 nsecs and that GLU166 residue is pivotal for binding.
PMC7654232; Comparison of efficacy of dexamethasone and methylprednisolone in moderate to severe covid 19 disease	Fatima,  SA,  Asif, et al	Ann Med Surg (Lond)	Clinical data| Données cliniques Therapeutics| Thérapeutique	The objective of this study was to compare the efficacy and safety of dexamethasone and methylprednisolone in moderate to severe covid 19 disease. Dexamethasone and methylprednisolone both are equally effective in treating moderate to severe covid 19 disease.
Clinical performances of three fully automated anti-SARS-CoV-2 immunoassays targeting the nucleocapsid or spike proteins	Favresse,  J,  Cadrobbi, et al	J Med Virol	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	This study assesses the clinical performances of three anti-SARS-CoV-2 assays, namely EUROIMMUN anti-SARS-CoV-2 nucleocapsid (IgG) ELISA, Elecsys anti-SARS-CoV-2 nucleocapsid (total antibodies) assay, and LIAISON anti-SARS-CoV-2 spike proteins S1 and S2 (IgG) assay. All three anti-SARS-CoV-2 assays had equivalent sensitivities 14 days from symptom onset to diagnose past-COVID-19 infection.
Incidence of COVID-19 among people living with HIV in Southern Spain	Fernandez-Fuertes,  Marta,  Rodriguez-Pineda, et al	Research Square prepub	Epidemiology| Épidémiologie	This study was carried out in order to reveal the actual incidence of SARS-CoV-2 infection in  people living with HIV (PLWH) in Southern Spain.  The incidence of COVID-19 among PLWH in our area was low and similar to that observed in the general population.
Simple Accurate Regression-Based Forecasting of Intensive Care Unit Admissions due to COVID-19 in Ontario, Canada	Fisman,  David,  Tuite, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé	We hypothesized that differential ICU burden might be explained by increased testing volumes, as well as the shift in mean case age from older to younger. We constructed a negative binomial regression model using only three covariates, at a 2-week lag: log10(weekly cases); log10(weekly deaths); and mean weekly case age. This model reproduced observed ICU admission volumes, and demonstrated good preliminary predictive validity. Furthermore, when admissions were used in combination with ICU length of stay, our modeled estimates demonstrated excellent convergent validity with ICU occupancy data reported by the Canadian Institute for Health Information.
PMC7430184; Clinical and laboratory evaluation of SARS-CoV-2 lateral flow assays for use in a national COVID-19 seroprevalence survey	Flower,  B,  Brown, et al	Thorax	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Of the infected cohort, 95% (95% CI 92.2% to 97.3%) had detectable antibodies on at least one ELISA. LFIA sensitivity was variable, but significantly inferior to ELISA in 8 out of 11 assessed. Of LFIAs assessed in both clinic and laboratory, finger-prick self-test sensitivity varied from 21% to 92% versus PCR-confirmed cases and from 22% to 96% versus composite ELISA positives. Concordance between finger-prick and serum testing was at best moderate (kappa 0.56) and, at worst, slight (kappa 0.13). All LFIAs had high specificity (97.2%-99.8%).
Association Between Proportion of Workday Treating COVID-19 and Depression, Anxiety, and PTSD Outcomes in U.S. Physicians	Gainer,  DM,  Nahhas, et al	J Occup Environ Med	Mental Health | santé mentale	The primary objective of this cross-sectional study was to examine the association between time spent treating patients with COVID-19 and levels of depression, anxiety, and post-traumatic stress disorder (PTSD) in U.S. physicians. In a sample of 1,724 U.S. physicians, proportion of day treating COVID-19 was positively and significantly associated with depression, anxiety, and PTSD scores (p < .001 for each).
Cytokine Storm May Not Be the Chief Culprit for the Deterioration of COVID-19	Gao,  Y,  Wang, et al	Viral Immunol	Epidemiology| Épidémiologie Clinical data| Données cliniques	In this study we aim to determine whether cytokine storm is really the chief culprit for the deterioration of COVID-19. The confirmed COVID-19 patients were divided into moderate group (n = 89), severe group (n = 37), and critical group (n = 41). The number of patients without comorbidities exceed one third (36.1%), and patients with 1, 2, 3, 4 kinds of comorbidities accounted for 23.0%, 23.0%, 13.1%, and 4.9%, respectively. IL-6, IL-10, TNF, and IFN-γ, including oxygenation index, sequential organ failure assessment score, white blood cell count, lymphocyte count, lymphocyte percentage, platelet, C-reaction protein, lactate dehydrogenase, creatine kinase isoenzyme, albumin, D-Dimer, and fibrinogen showed significant difference between groups.
PMC7661950; Population agglomeration is a harbinger of the spatial complexity of COVID-19	Geng,  X,  Gerges, et al	Chem Eng J	Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*| Interventions de sant&amp;eacute; publique	The ramifications of targeted interventions on spatial patterns of new infections were explored using the epidemiological susceptible-infectious-recovered (SIR) model mapped onto the population agglomeration template. These revealed that re-opening rural areas would have a smaller impact on the spread and evolution of the disease than re-opening urban (dense) centers which would disturb the system for months. This study provided a novel way for interpreting the spatial spread of COVID-19, along with a practical approach (multifractals/SIR/spectral slope) that could be employed to capture the variability and intermittency at all scales while maintaining the spatial structure.
Adhatoda Vasica: A Potential Ayurvedic Intervention Against COVID-19 Associated Impaired Immune Response and Hypoxia-Inflammation Phenotype	Gheware,  Atish Prabhakar,  Dholakia, et al	Research Square prepub	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	In this study we tested the effect of whole aqueous extract Adhatoda Vasica (AV), that our group has shown to have anti-hypoxic and anti-inflammatory effects, on various outcomes of hypoxic response.  These genes and pathways show opposite expression in transcriptome of BALF and PBMCs of SARS-CoV2 infected patient. Molecular docking of AV constituents presents in extract reveal many molecules with low binding energy (≤ -8) to multiple SARS-CoV2 and host target proteins that are relevant in viral entry and replication.
A Patient with COVID-19 Pneumonia Presenting with Plural Effusion: A Case Report	Ghiasvand,  F,  SeyedAlinaghi, et al	Infect Disord Drug Targets	Clinical data| Données cliniques	In February 2020, coronavirus disease (COVID-19) emerged in Tehran, Iran. Herein, we reported clinical features, laboratory tests, unusual radiological characteristics and therapeutic course of a patient with initial mild clinical symptoms at presentation with progression to pneumonia and pleural effusion in emergency unit of a referral hospital.
Role of ROX Index in the first assessment of COVID-19 patients in the Emergency Department	Gianstefani,  Alice,  Farina, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	The aim of the study was to evaluate the accuracy of ROX index in predicting hospitalization and mortality in patients with suspected diagnosis of COVID-19 in the ED. Secondary outcomes were to assess the number of readmissions and the variations of ROX index between first and second admission.  ROX index, together with laboratory, imaging and clinical findings, can help discriminate patients suspected for COVID-19 requiring hospital admission, their clinical severity and their mortality risk. Furthermore, it can be useful to better manage these patients in territorial healthcare services, especially in the hypothesis of another pandemic.
COVID-19 and the stock market: evidence from Twitter	Goel,  Rahul,  Ford, et al	arXiv	Economics | Économie	COVID-19 has had a much larger impact on the financial markets compared to previous epidemics because the news information is transferred over the social networks at a speed of light. Using Twitter's API, we compiled a unique dataset with more than 26 million COVID-19 related Tweets collected from February 2nd until May 1st, 2020. We find that more frequent use of the word "stock" in daily Tweets is associated with a substantial decline in log returns of three key US indices - Dow Jones Industrial Average, S&P500, and NASDAQ. The results remain virtually unchanged in multiple robustness checks.
Characteristics of Clinically Asymptomatic Patients with SARS-CoV-2 Infections, Case Series	Goldenfeld,  M,  Nir-Paz, et al	Prehosp Disaster Med	Transmission Clinical data| Données cliniques	This article aims to describe key features and the nature of asymptomatic and pauci-symptomatic SARS-CoV-2 infected patients.  This case series demonstrates that asymptomatic and pauci-symptomatic patients may play a role in infection transmission by demonstrating probable transmission among asymptomatic spouses and by demonstrating a viable virus via a cell culture. Additionally, asymptomatic and pauci-symptomatic patients can have lung pathology and developing IgG antibodies.
Carbapenemase-producing Enterobacterales causing secondary infections during the COVID-19 crisis at a New York City hospital	Gomez-Simmonds,  A,  Annavajhala, et al	J Antimicrob Chemother	Clinical data| Données cliniques	We sought to rapidly investigate the clinical characteristics, population structure and mechanisms of resistance of  carbapenemase-producing Enterobacterales (CPE) causing secondary infections in patients with COVID-19. Most patients (11/13) had a positive respiratory culture and 7/13 developed bacteraemia; treatment failure was common. Twenty isolates were available for WGS. Most K. pneumoniae (16/17) belonged to ST258 and encoded KPC (15 KPC-2; 1 KPC-3); one ST70 isolate encoded KPC-2. E. cloacae isolates belonged to ST270 and encoded NDM-1. Nanopore sequencing enabled identification of at least four distinct ST258 lineages in COVID-19 patients, which were validated by Illumina sequencing data.
Calculation of a local COVID-19 reproduction number for the northern Rhineland-Palatinate	Götz,  Thomas,  Mohrmann, et al	arXiv	Modelling/ prediction| Modélisation/prédiction Transmission	In the present article, the calculations of the RKI on a local level are examined using the example of northern Rhineland-Palatinate and its districts (Germany). The calculation of the daily value of Rt between the end of February and the end of October showed a similar course of the reproductive rate compared to the nationwide figures. Expectably larger statistical fluctuations were observed in the summer, mainly due to lower case numbers. The values for northern Rhineland-Palatinate have been consistently above 1 since about mid-September. The calculations can also be transferred to other regions and administrative districts.
Pyrexia by COVID-19 in a patient treated with dabrafenib/trametinib therapy	Hashimoto,  H,  Ito, et al	J Dermatol	Clinical data| Données cliniques	Here, we report a case of coronavirus disease 2019 (COVID‐19) with pyrexia and fatigue while receiving BRAFi + MEKi.
Genetic Liability to Cannabis Use Disorder and COVID-19 Hospitalization	Hatoum,  AlexanderS,  Morrison, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	We leveraged genome-wide association study (GWAS) summary statistics to estimate whether genetic liability to Cannabis Use Disorder (CUD) may plausibly influence COVID-19 hospitalization . We find that at least 1/3rd of the genetic vulnerability to COVID-19 overlaps with genomic liability to (CUD) (rg=.34, p=0.0003).
Association of Body Mass Index and Age With Morbidity and Mortality in Patients Hospitalized With COVID-19: Results From the American Heart Association COVID-19 Cardiovascular Disease Registry	Hendren,  NS,  de Lemos, et al	Circulation	Epidemiology| Épidémiologie Clinical data| Données cliniques	We analyzed data from patients hospitalized with COVID-19 at 88 US hospitals enrolled in the American Heart Association’s COVID-19 Cardiovascular Disease Registry with data collection through July 22, 2020 in order to assess COVID-19 outcomes  and BMI.  After multivariable adjustment, classes I to III obesity were associated with higher risks of in-hospital death or mechanical ventilation (odds ratio, 1.28 [95% CI, 1.09–1.51], 1.57 [1.29–1.91], 1.80 [1.47–2.20], respectively), and class III obesity was associated with a higher risk of in-hospital death (hazard ratio, 1.26 [95% CI, 1.00–1.58]).
Tocilizumab in hospitalized patients with COVID-19: Clinical outcomes, inflammatory marker kinetics, and safety	Hill,  JA,  Menon, et al	J Med Virol	Clinical data| Données cliniques Therapeutics| Thérapeutique	We conducted a retrospective study of patients admitted to the University of Washington Hospital system with COVID‐19 and requiring supplemental oxygen. We used Cox proportional‐hazards models with propensity score inverse probability weighting to compare outcomes in patients who did and did not receive tocilizumab. Tocilizumab treatment was associated with reduced CRP, fibrinogen, and temperature, but there were no meaningful differences in time to clinical improvement (adjusted hazard ratio [aHR], 0.92; 95% CI, 0.38‐2.22) or mortality (aHR, 0.57; 95% CI, 0.21‐1.52). A numerically higher proportion of tocilizumab‐treated patients had subsequent infections, transaminitis, and cytopenias.
Impact of COVID-19 on the Hong Kong Youth Quitline Service and Quitting Behaviors of Its Users	Ho,  LLK,  Li, et al	Int J Environ Res Public Health	Public Health response| Interventions de santé publique	We aimed to describe the impact of the COVID-19 pandemic on the Youth Quitline service and quitting behaviors of its users in Hong Kong. We conducted a telephone survey involving 201 participants of the Youth Quitline service, and retrospectively analyzed the operation and use of Quitline since the COVID-19 outbreak in Hong Kong. Many participants (68%) did not realize that tobacco use potentially increased their risk for developing and spreading COVID-19; however, 43% agreed that the pandemic motivated their intention to quit, and 83% changed their smoking habits during the pandemic. These changes were mainly due to wearing masks (30%), closure of bars/pubs (25%), suspension of classes (14%), and being unable to socialize with friends (24%). Overall, 58% reduced their tobacco use; of these participants, 66% reported a ≥50% reduction in daily cigarette consumption.
How fear and collectivism influence public's preventive intention towards COVID-19 infection: a study based on big data from the social media	Huang,  F,  Ding, et al	BMC Public Health	Public Health response| Interventions de santé publique	The present study examines the combined effect of fear and collectivism on the public’s preventive intention towards COVID-19 through the analysis of a Chinese social media  posts. The study reveals that: (a) both fear and collectivism can positively predict people’s preventive intention and (b) there is an interaction of fear and collectivism on people’s preventive intention, where fear and collectivism reduce each other’s positive influence on people’s preventive intention.
Influenza Vaccination and the Risk of COVID-19 Infection and Severe Illness in Older Adults in the United States	Huang,  Kelly,  Lin, et al	Research Square prepub	Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	This is a retrospective cross-sectional study with investigates the impact of influenza vaccination and the risk of COVID-19 infection. We use data from Symphony Health database from July 1, 2019, to June 30, 2020. Participants were adults aged 65 years old or older who had received the influenza vaccine between September 1 and December 31 of 2019.  The adjusted odds ratio (aOR) of COVID-19 infection risk between the influenza-vaccination group and no-influenza-vaccination group was 0.76 (95% confidence interval (CI), 0.75–0.77). Among COVID-19 patients, the aOR of developing severe COVID-19 illness was 0.72 (95% CI, 0.68–0.76) between the influenza-vaccination group and the no-influenza-vaccination group. When the influenza-vaccination group and the other-vaccination group were compared, the aOR of COVID-19 infection was 0.95 (95% CI, 0.93–0.97), and the aOR of developing a severe COVID-19 illness was 0.95 (95% CI, 0.80–1.13). In conclusion, the influenza vaccine may marginally protect people from COVID-19 infection.
Remote monitoring of cardiac implantable devices during COVID-19 outbreak: "keep people safe" and "focus only on health care needs"	Iacopino,  S,  Placentino, et al	Acta Cardiol	Healthcare Response | Réponse des soins de santé	We report the experience of a national tertiary electrophysiology centre in the management of patients with cardiac implantable electronic devices (CIEDs) through the use of a fully remote follow-up model. During the study period (25 days), we received 2,215 transmissions from 2,955 devices. Among them, 129 patients reported potential clinically actionable remote monitoring (RM) observations (event rate: 12.0/1000 patient-week). In 77 patients (60%), RM events triggered a clinical action, but only 5 patients needed an urgent in-hospital access (4 urgent procedures and 1 device reprogramming).
Toward More Effective Public Health Interventions during the COVID-19 Pandemic: Suggesting Audience Segmentation Based on Social and Media Resources	Ihm,  J,  Lee, et al	Health Commun	Mental Health | santé mentale	We investigate the role of social and media resources in complementing limited offline communication and supporting mental and physical health during this pandemic. We then suggest an alternative audience segmentation strategy based on social and media resources for public health interventions. Based on online survey data from 723 adults in South Korea, the regression analysis results indicated that individuals with lower levels of social resources suffered more during the pandemic. The cluster analysis results revealed that, contrary to the traditional definition of vulnerable populations, a cluster of younger people were unhealthier than a cluster of older people because of a lack of social resources. Clusters with different levels of information communication technology skills (ICT) skills and uses for health-related activities also experienced the pandemic differently.
Accuracy of deep learning based computed tomography diagnostic system of COVID-19: a consecutive sampling external validation cohort study	Ikenoue,  Tatsuyoshi,  Kataoka, et al	medRxiv	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In this retrospective cohort study, COVID-19 infection probabilities were calculated using Ali-M3 (an artificial intelligence that analyses chest computed tomography (CT)) was used in 617 symptomatic patients who underwent reverse transcription-polymerase chain reaction (RT-PCR) tests and chest CT for COVID-19 diagnosis in order to evaluate the external validity  of Ali-M3. The area under the curve (AUC) of Ali-M3 for predicting a COVID-19 diagnosis was 0.797 (95% confidence intervals [CI]: 0.762‒0.833) and goodness-of-fit was P = 0.156. With a cut-off of probability of COVID-19 by Ali-M3 diagnosis set at 0.5, the sensitivity and specificity were 80.6% and 68.3%, respectively, while a cut-off of 0.2 yielded a sensitivity and specificity of 89.2% and 43.2%, respectively.
Decision and Feature Level Fusion of Deep Features Extracted from Public COVID-19 Data-sets	Ilhan,  Hamza Osman,  Serbes, et al	arXiv	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In our study, a computer-aided diagnosis system for X-ray images based on convolutional neural networks (CNNs), which can be used by radiologists as a supporting tool in COVID-19 detection, has been proposed. Deep feature sets extracted by using CNNs were concatenated for feature level fusion and fed to multiple classifiers in terms of decision level fusion idea with the aim of discriminating COVID-19, pneumonia and no-finding classes. The experimental results show that the proposed approach has attained high COVID-19 detection performance that was proven by its comparable accuracy and superior precision/recall values with the existing studies.
The impact of the coronavirus disease 2019 (COVID-19) outbreak on hospital admissions for alcohol-related liver disease and pancreatitis: a time-series analysis	Itoshima,  Hisashi,  Shin, et al	medRxiv	Public Health response| Interventions de santé publique	The aim of this study was to examine the population-level change in cases of alcohol-related liver disease and pancreatitis that required admission during the COVID-19 outbreak in Japan. Overall admissions were 3,026,389 cases, and a total of 10,242 admissions for alcohol-related liver disease or pancreatitis occurred from 257 hospitals. The rate of admissions per 1,000 admissions during the COVID-19 outbreak period (April 2020 to June 2020) had a 1.2 times increase compared with the pre-outbreak period (July 2018 to March 2020) for cases of alcohol-related liver disease or pancreatitis (RR: 1.22, 95%Confidence interval [CI]: 1.12 to 1.33).
Adherence of the General Public to Self-protection Guidelines During the COVID-19 Pandemic	Jabbari,  P,  Taraghikhah, et al	Disaster Med Public Health Prep	Public Health response| Interventions de santé publique	In this cross-sectional study, we investigated adherence of the general public to use of PPE and their knowledge regarding the rationale behind their use in Tehran. Approximately, half of the 431 participants did not take any measures to ensure hand hygiene, while those who did not use respiratory protection were far fewer. A considerable number of individuals, however, did not use these PPE correctly. On the other hand, there was a gap in the knowledge of the general public regarding different aspects of protective measures. The majority of the participants were receptive towards education on preventive measurements through public media.
PURPURONA: A NOVEL REPORT OF COVID-19-RELATED HENOCH-SCHONLEIN PURPURA IN A CHILD	Jacobi,  M,  Lancrei, et al	Pediatr Infect Dis J	Clinical data| Données cliniques	We describe a novel case of a 3-year-old male with a clinical diagnosis of Henoch–Schonlein Purpura vasculitis with concurrent SARS-CoV-2 infection. This case highlights a potentially newly described presentation of coronavirus disease 2019 infection.
Sensitivity of mid-turbinate versus nasopharyngeal swabs for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)	Jamal,  AJ,  Mozafarihashjin, et al	Infect Control Hosp Epidemiol	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	To compare sensitivity of specimens for COVID-19 diagnosis, we tested 151 nasopharyngeal/mid-turbinate swab pairs from 117 COVID-19 inpatients using RT-PCR. Sensitivity was 94% for nasopharyngeal and 75% for mid-turbinate swabs (p=0.0001). In 88 nasopharyngeal/mid-turbinate pairs with matched saliva, sensitivity was 86% for nasopharyngeal swabs and 88% for combined mid-turbinate swabs/saliva.
PMC7661912; Use of convalescent plasma therapy in Eight mild COVID-19 patients	Ji,  F,  Liu, et al	New Microbes New Infect	Clinical data| Données cliniques Therapeutics| Thérapeutique	This study recruited 8 mild COVID-19 patients received at least one dose of CP transfusion. After CP therapy, all patients improved the clinical symptoms. The level of lymphocyte counts tended to increase, meanwhile LDH, CK and AST tended to decrease. However, CRP of 3 patients increased transiently. The median time that SARS-CoV-2 nucleic acid of the patients turned to negative was 2.5d after CP transfusion. The study shows the potential benefits of CP. Meanwhile, CP probably enhances the inflammatory response to SARS-CoV-2 temporarily in the patients with insufficient antiviral immunity. However, the effects of CP are not permanent.
Prognostic value of bedside lung ultrasound score in patients with COVID-19	Ji,  Li,  Cao, et al	Research Square prepub	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	We aimed to investigate the prognostic value of the LUS score in patients with COVID-19.  Patients in the highest LUS score group were more likely to have a lower lymphocyte percentage (LYM%); higher levels of D-dimer, C-reactive protein, hypersensitive troponin I and creatine kinase muscle-brain; more invasive mechanical ventilation therapy; higher incidence of ARDS; and higher mortality than patients in the lowest LUS score group. Patients with adverse outcomes presented a higher rate of bilateral involvement; more involved zones and B-lines, pleural line abnormalities and consolidation; and a higher LUS score than event-free survivors. An LUS score cut-off >12 predicted adverse outcomes with a specificity and sensitivity of 90.5% and 91.9%, respectively. The LUS score devised by our group performs well at predicting adverse outcomes in patients with COVID-19 and is important for risk stratification in COVID-19 patients.
Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing, membrane fusion, and viral infectivity	Jiang,  X,  Zhang, et al	Signal Transduct Target Ther	Coronavirology| Coronavirologie	it is proposed that the SARS-CoV-2 variant of G614 genotype is highly transmissible, which is probably attributed to an increased S2 production associated with bi-modularly altered S-trimer stability, leading to enhanced membrane fusion and host entry.
Characteristics, onset, and evolution of neurological symptoms in patients with COVID-19	Kacem,  I,  Gharbi, et al	Neurol Sci	Clinical data| Données cliniques	In this paper, we describe the neurological symptoms associated with COVID-19, their main characteristics, and their evolution in the Tunisian population followed by discussion of their underlying pathophysiological mechanisms. Neurological symptoms were isolated 22.7% (n = 106). Headache was the most frequent neurological symptom (n = 279, 41.1%): mainly frontotemporal (n = 143, 51.1%) and mild or moderate (n = 165, 59.1%). When associated with fever (n = 143, 51.3%), headache was more likely to be severe and present at onset. Recovery was reported in 83.2%. Smell and taste impairment were found in 37.9% (n = 245) and 36.8% (n = 238) respectively. Among them, 65.3% (156/239) were anosmic and 63.2% (146/231) were ageusic. A complete improvement was found in 72.1% (174/240) of smell impairment and in 76.8% (179/233) of taste impairment. Myalgia (n = 241, 37.3%) and sleep disturbances (n = 241, 37.3%) were also frequent. Imported cases had more neurological symptoms (p = 0.001). In 14.5%, neurological symptoms preceded the respiratory signs (RS). RS were associated with more frequent (p = 0.006) and numerous (p < 0.001) neurological symptoms.
PMC7657028; Lymphocyte subsets in haematological patients with COVID-19: Multicentre prospective study	Kalicińska,  E,  Szymczak, et al	Transl Oncol	Immunology | Immunologie	Here, we performed a comprehensive analysis of peripheral blood lymphocyte subsets in 27 SARS-CoV-2-infected patients, including 16 patients with haematological malignancies. We identified T cell subpopulations, B cells, NK cells and TCR α/ß and ɣ/ƍ-expressing T cells during COVID-19 infection, with significant changes observed in immune profiles during the course of disease, especially in haematological patients. We observed an increase in activated T lymphocytes (CD3+HLA-DR+ and CD3+CD8+HLA-DR+) in the early stages of SARS-CoV-2 infection with a concomitant decrease in the CD4/CD8 ratio in haematological patients compared to non-haematological patients affected by COVID-19. We also found a decrease in ɣ/ƍ T cells in both studied groups of patients, with lower numbers of CD25+ T cells and CD16+CD56+ NK cells in haematological patients compared to non-haematological patients with COVID-19. Our findings demonstrate, for the first time, impaired adaptive immunity in patients with haematological malignancies infected with COVID-19, resulting in impaired cellular immune responses to SARS-CoV-2.
The κ-statistics approach to epidemiology	Kaniadakis,  G,  Baldi, et al	Sci Rep	Epidemiology| Épidémiologie	In this paper, we use κ-statistics to formulate a statistical approach for epidemiological analysis. We validate the theoretical results by fitting the derived κ-Weibull distributions with data from the plague pandemic of 1417 in Florence as well as data from the COVID-19 pandemic in China over the entire cycle that concludes in April 16, 2020. As further validation of the proposed approach we present a more systematic analysis of COVID-19 data from countries such as Germany, Italy, Spain and United Kingdom, obtaining very good agreement between theoretical predictions and empirical observations. For these countries we also study the entire first cycle of the pandemic which extends until the end of July 2020. The fact that both the data of the Florence plague and those of the Covid-19 pandemic are successfully described by the same theoretical model, even though the two events are caused by different diseases and they are separated by more than 600 years, is evidence that the κ-Weibull model has universal features.
COVID-19 outcomes in UK centre within highest health and wealth band: a prospective cohort study	Ken-Dror,  G,  Wade, et al	BMJ Open	Epidemiology| Épidémiologie Clinical data| Données cliniques	This prospective study describes the characteristics and outcomes of hospitalised patients with COVID-19 from UK in the highest decile of health and gross regional products per capita. Despite reports of worse outcomes in deprived regions, we show similar complication and mortality rates due to COVID-19 in an affluent and high life expectancy region.
A Giant Right-Heart Thrombus-in-Transit in a Patient with COVID-19 Pneumonia	Khan,  HMW,  Khan, et al	Am J Case Rep	Clinical data| Données cliniques	We present a case of COVID-19 pneumonia in a warehouse worker with a giant thrombus-in-transit involving the right ventricle and tricuspid valve.
Diesel Particulate Matter 2.5 Induces Epithelial-to-Mesenchymal Transition and Upregulation of SARS-CoV-2 Receptor during Human Pluripotent Stem Cell-Derived Alveolar Organoid Development	Kim,  JH,  Kim, et al	Int J Environ Res Public Health	Coronavirology| Coronavirologie	we investigated the developmental toxicity of diesel fine PM (dPM2.5) exposure during hPSC-derived alveolar epithelial cell (AEC) differentiation and three-dimensional (3D) multicellular alveolar organoid (AO) development. We found that dPM2.5 (50 and 100 μg/mL) treatment disturbed the AEC differentiation, accompanied by upregulation of nicotinamide adenine dinucleotide phosphate oxidases and inflammation. Exposure to dPM2.5 also promoted epithelial-to-mesenchymal transition during AEC and AO development via activation of extracellular signal-regulated kinase signaling, while dPM2.5 had no effect on surfactant protein C expression in hPSC-derived AECs. Notably, we provided evidence, for the first time, that angiotensin-converting enzyme 2, a receptor to mediate the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) entry into target cells, and the cofactor transmembrane protease serine 2 were significantly upregulated in both hPSC-AECs and AOs treated with dPM2.5.
Depression in Public officials during the COVID-19 Pandemic in Paraguay: A Web-based Study	Kim,  Ji Eon,  Lee, et al	Research Square prepub	Mental Health | santé mentale	This study investigated the factors influencing depressive feelings in Paraguayan public officials caused by the coronavirus disease (COVID-19) pandemic. The results of Model 4 indicated high levels of depressive feelings among public officials, as well as concerns about COVID-19 infection among female public officials. The study also found that public officials’ high levels of depressive feelings were related to the duration of COVID-19 self-quarantine periods.
Expression Analyses of MicroRNAs in Hamster Lung Tissues Infected by SARS-CoV-2	Kim,  WR,  Park, et al	Mol Cells	Coronavirology| Coronavirologie Animal model | Modèle animal	In our research, microRNAs (miRNAs) binding to the genome sequences of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory-related coronavirus (MERS-CoV), and SARS-CoV-2 were identified by bioinformatic tools. We also identified miRNAs that bind to receptor proteins, such as ACE2, ADAM17, and TMPRSS2, which are important for understanding the infection mechanism of SARS-CoV-2. The expression patterns of those miRNAs were examined in hamster lung samples infected by SARS-CoV-2.
Relationship between Phobic Anxiety in Work and Leisure Activity Situations, and Optimistic Bias Associated with COVID-19 among South Koreans	Kim,  YJ,  Kim, et al	Int J Environ Res Public Health	Mental Health | santé mentale	the present study investigated the differences in phobic anxiety between work and leisure activities according to optimistic bias among 533 South Korean citizens. The results showed that for leisure activities, women showed a higher perception of phobic anxiety. In addition, the group showing high optimistic bias had a higher perception of phobic anxiety in both work and leisure activity situations.
Validation of Chest Computed Tomography Artificial Intelligence to Determine the Requirement for Mechanical Ventilation and Risk of Mortality in Hospitalized Coronavirus Disease-19 Patients in a Tertiary Care Center In Mexico City	Kimura-Sandoval,  Y,  Arévalo-Molina, et al	Rev Invest Clin	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	The objectives pf the study were to analyze the performance of a chest computed tomography (CT) AI quantitative algorithm for determining the risk of mortality/mechanical ventilation (MV) in hospitalized COVID-19 patients and explore a prognostic multivariate model in a tertiary-care center in Mexico City. The AI-calculated CT severity score and total opacity percentage showed good diagnostic accuracy for mortality and met MV criteria. The proposed prognostic models using biochemical variables and imaging data measured by AI on chest CT showed good risk classification in our population of hospitalized COVID-19 patients.
Clinical, regional, and genetic characteristics of Covid-19 patients from UK Biobank	Kolin,  DA,  Kulm, et al	PLoS One	Epidemiology| Épidémiologie Clinical data| Données cliniques	In this study, we analyzed the effects of clinical, regional, and genetic factors on Covid-19 positive status. This prospective cohort study included 397,064 UK Biobank participants, of whom 968 tested positive for Covid-19. When assessing the association of Black race with Covid-19, adjusting for deprivation reduced the relative risk of Covid-19 by 33%. In the context of sociological research, these findings suggest that discrimination in the labor market may play a role in the high relative risk of Covid-19 for Black individuals. In this study, we also confirmed the association of blood type A with Covid-19, among other clinical and regional factors.
Potential SARS-CoV-2 protease Mpro inhibitors: Repurposing FDA-approved drugs	Kouznetsova,  VL,  Huang, et al	Phys Biol	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Using as a template the crystal structure of COVID-19 main protease, we developed a pharmacophore model of functional centers of the protease inhibitor-binding pocket. With this model, we conducted data mining of the conformational database of FDA-approved drugs. This search brought 64 compounds that can be potential inhibitors of COVID-19 protease.  Three of the selected compounds were carfilzomib, cyclosporine A, and azithromycin—the drugs that already are tested for COVID-19 treatment. Among the selected compounds are two HIV protease inhibitors and two hepatitis C protease inhibitors.
COVID-19: Characteristics, ventilation and courses of patients in the Lombardy region	Krome,  S	Pneumologie	Epidemiology| Épidémiologie Clinical data| Données cliniques	This retrospective observational study of COVID-19 ICU patients in the Lombardy region of Italy revealed particular risks and treatment problems for people with COVID-19 in intensive care units. Most of the patients were older men, many of whom had to be invasively ventilated with a high PEEP. A total of every 4th sick person died. The median age of the critically ill did not differ from the mean age of all Italian infected people. This underpins that age alone is not a risk factor.
Multiscale PHATE Exploration of SARS-CoV-2 Data Reveals Multimodal Signatures of Disease	Kuchroo,  Manik,  Huang, et al	bioRxiv	Epidemiology| Épidémiologie Immunology | Immunologie	To uncover biological meaning from complex COVID-19 high dimensional datasets, we present an approach called Multiscale PHATE, which learns abstracted biological features from data that can be directly predictive of disease. We apply Multiscale PHATE to study the immune response to COVID-19 in 54 million cells from 168 hospitalized patients. Through our analysis of patient samples, we identify CD16hiCD66lo neutrophil and IFNγ+GranzymeB+ Th17 cell responses enriched in patients who die.
Changes in the obstetrical emergency department profile during the COVID-19 pandemic	Kugelman,  N,  Lavie, et al	J Matern Fetal Neonatal Med	Healthcare Response | Réponse des soins de santé	We evaluate the effect of the COVID-19 pandemic on admission rates to the delivery room and the feto-maternal unit, and to assess the effect on the nature of presenting obstetrical complaints to the emergency department. The pandemic outbreak of COVID-19 caused a behavioral change among women who presented to the obstetrical emergency department. This was characterized by delayed arrival to the obstetrical emergency department and the delivery room, which led to a significant increase in urgent and acute interventions.
Secondary attack rate and family clustering of SARS-CoV-2 infection in children of healthcare workers with confirmed COVID-19	Ladhani,  SN,  Andrews, et al	Clin Infect Dis	Epidemiology| Épidémiologie Transmission	We measured serum SARS-CoV-2 antibodies in 215 children of healthcare workers to estimate secondary attack rates (SAR). Twenty-one families had a parent with confirmed COVID-19. There was strong evidence of family clustering (P<0.001): 20/21 (95.2%) children were seropositive in 9 families and none of 23 children in 12 other families.
Estimated impact of the COVID-19 pandemic on cancer services and excess 1-year mortality in people with cancer and multimorbidity: near real-time data on cancer care, cancer deaths and a population-based cohort study	Lai,  AG,  Pasea, et al	BMJ Open	Healthcare Response | Réponse des soins de santé	We estimate the impact of the COVID-19 pandemic on cancer care services and overall (direct and indirect) excess deaths in people with cancer. Dramatic reductions were detected in the demand for, and supply of, cancer services which have not fully recovered with lockdown easing. These may contribute, over a 1-year time horizon, to substantial excess mortality among people with cancer and multimorbidity.
Taylor collocation method for a system of nonlinear Volterra delay integro-differential equations with application to COVID-19 epidemic	Laib,  Hafida,  Bellour, et al	Research Square prepub	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	The main purpose of this work is to provide a current numerical method based on the use of continuous collocation Taylor polynomials for the numerical solution of nonlinear VDIDEs systems. We apply two models to the COVID-19 epidemic in China and one for the Predator-Prey model in mathematical ecology.
Modeling the impact of school reopening on SARS-CoV-2 transmission using contact structure data from Shanghai	Lee,  B,  Hanley, et al	BMC Public Health	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	We adapted a previously published model using contact information from Shanghai to model school reopening under various conditions. We investigated different strategies by combining the contact patterns observed between different age groups during both baseline and “lockdown” periods. We find that reopening schools for all children would maintain a post-intervention R0 < 1 up to a baseline R0 of approximately 3.3 provided that daily contacts among children 10–19 years are reduced to 33% of baseline.
A New Compartmental Epidemiological Model for COVID-19 with a Case Study of Portugal	Lemos-Paiao,  Ana,  Silva, et al	arXiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	We propose a compartmental mathematical model for the spread of the COVID-19 disease, showing its usefulness with respect to the pandemic in Portugal, from the first recorded case in the country till the end of the three states of emergency. the proposed model allows to describe quite well the spread of COVID-19 in Portugal, fitting simultaneously not only the number of active infected individuals but also the number of hospitalized individuals, respectively with a L2 error of 9.2152e−04 and 1.6136e−04 with respect to the initial population.
Prediction of COVID-19 Severity Using Chest Computed Tomography and Laboratory Measurements: Evaluation Using a Machine Learning Approach	Li,  D,  Zhang, et al	JMIR Med Inform	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study aimed to develop an effective prediction model for COVID-19 severity by combining radiological outcome with clinical biochemical indexes. A total of 46 patients with COVID-19 (10 severe, 36 nonsevere) were examined. To build the prediction model, a set of 27 severe and 151 nonsevere clinical laboratory records and computerized tomography (CT) records were collected from these patients.
The Rhinolophus affinis bat ACE2 and multiple animal orthologs are functional receptors for bat coronavirus RaTG13 and SARS-CoV-2	Li,  Pei,  Guo, et al	bioRxiv	Coronavirology| Coronavirologie zoonoses	Found that the RaTG13 spike (S) protein is significantly less fusogenic than SARS-CoV and SARS-CoV-2, and seven out of sixteen different ACE2s function as entry receptors for all three viruses, indicating that the viruses (RaTG13 and SARS-CoV-2) might have broad host rages. Mutagenesis analysis revealed that residues 484 and 498 in RaTG13 and SARS-CoV-2 S proteins play critical roles in recognition of mouse and human ACE2.
Psychological characteristics of parents in a Paediatric Outpatient during the SARS-CoV-2 Epidemic	Li,  X,  Wu, et al	Psychol Health Med	Mental Health | santé mentale	Analyzed and summarized the psychological status of  parents (n=18 000)  who visited a paediatric clinic in China during the COVID-19 pandemic. The analysis found that among parents, women show more anxiety than men during treatment, and that they are more inclined to express fear and anxiety. Compared with young people, elderly people over 50 years of age are more nervous and have more difficulty communicating.
Changes in Emergency Department Responses Between SARS and COVID-19 in Taiwan	Lin,  Chia Wei,  Lin, et al	Research Square prepub	Healthcare Response | Réponse des soins de santé	Compared emergency department (ED) responses to the SARS and COVID-19 epidemics in Taiwan and investigate how policy changes affect infection prevention.  The study concludes after the policy reforms from SARS, ED responses became earlier and more consistent.
Development of Multivalent Nanobodies Blocking SARS CoV 2 Infection by Targeting RBD of Spike Protein	Lu,  Qizhong,  Zhang, et al	Research Square prepub	Coronavirology| Coronavirologie	Multivalent nanobodies with high affinity blocking SARS CoV 2 spike interaction with ACE2 protein were developed and four specific nanobodies against spike protein and its RBD domain were screened from a naïve VHH library. The study concludes VHH library could be used as a potential resource for rapid acquisition and exploitation of antiviral nanobodies. Heterodimer nanobody Nb91 Nb3 hFc may serve as a potential therapeutic agent for the treatment of COVID 19.
Demystifying the spreading of pandemics I: The fractal kinetics SI model quantifies the dynamics of COVID-19	Macheras,  Panos,  Kosmidis, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	The models used so far for the epidemic spreading, based on the “well mixed” hypothesis, are oversimplifications of the reality. This explains the low predictive power of these models (1). The hypothesis free fractal kinetics SI model captures the dynamics of the pathogens’ transmission from the infected to susceptible subjects since the imperfect mixing of the individuals and the self-organization of the societies against the pandemic through social distancing, e.g. masks, lockdowns, flight restrictions etc lie at the heart of fractal kinetics
Assessment of protein-protein interfaces in cryo-EM derived assemblies	Malhotra,  Sony,  Joseph, et al	bioRxiv	Coronavirology| Coronavirologie	Developed a protein interaction score, a density-independent machine learning-based metric, trained using protein-protein interfaces’ features in high-resolution crystal structures to study protein protein interactions. Using PI-score, the authors identify errors at interfaces in the PDB-deposited cryo-EM structures (including SARS-CoV-2 complexes) and in the models submitted for cryo-EM targets in CASP13 and the EM model challenge.
COVID-19 Quarantine-Related Mental Health Symptoms and their Correlates among Mothers: A Cross Sectional Study	Malkawi,  SH,  Almhdawi, et al	Matern Child Health J	Mental Health | santé mentale	Investigated reported mental health and changes in lifestyle practices among Jordanian mothers during COVID-19 quarantine.  The study found mothers with lower income, lower education, not employed, or living in cities outside the capital of Jordan reported having more depression, anxiety, and stress symptoms (p < .005). Changes in their lifestyle practices included weight gain, increased time allocated for teaching children at home, increased familial violence at home, and increased time allocated for caring for their family members (average increase of 5 hours daily).
PMC7543918; Re: extent of pulmonary thromboembolic disease in patients with COVID-19 on CT: relationship with pulmonary parenchymal disease	Marsland,  L,  Fang, et al	Clin Radiol	Clinical data| Données cliniques	Report the incidence of PTE in hospitalised patients with severe COVID-19 who have persistent respiratory illness well after their initial presentation, follow-up study. Study observations suggest that anticoagulation therapy is an effective treatment in COVID-19 patient with PTE.
Demographic and occupational determinants of anti-SARS-CoV-2 IgG seropositivity in hospital staff	Martin,  CA,  Patel, et al	J Public Health (Oxf)	Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé Immunology | Immunologie	Conducted a cross-sectional surveillance examining seroprevalence of anti-SARS-CoV-2 IgG amongst staff at a UK hospital. 10.8% hospital staff members were seropositive. Compared to White staff (seroprevalence 9.1%), seroprevalence was higher in South Asian (12.3%) and Black (21.2%) staff. The occupations and department with the highest seroprevalence were nurses/healthcare assistants (13.7%) and the Emergency Department (ED)/Acute Medicine (17.5%), respectively. Seroprevalence decreased with seniority in medical/nursing practitioners.
Nasopharyngeal Panbio COVID-19 antigen performed at point-of-care has a high sensitivity in symptomatic and asymptomatic patients with higher risk for transmission and older age	Masia,  Mar,  Fernandez-Gonzalez, et al	medRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Evaluate the performance of the nasopharyngeal Panbio COVID-19 antigen Rapid Test Device in real-life conditions in different clinical scenarios. The study concludes the nasopharyngeal Panbio COVID-19 antigen test performed at point-of-care is highly sensitive in symptomatic patients, particularly with Ct<30 and older age. The test was useful to identify asymptomatic patients with lower Ct values and therefore with contagious risk.
Clinical features of patients with acute coronary syndrome during the COVID-19 pandemic	Matsushita,  K,  Hess, et al	J Thromb Thrombolysis	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	Investigate the incidence, clinical presentation, and outcomes of patients with ACS during the COVID-19 pandemic. The study reports The COVID-19 outbreak was associated with a 40% decrease in AMI. The delay of STEMI care was minimal in our center, suggesting that the healthcare system effectiveness was maintained despite the pandemic. ACS patients tested positive for COVID-19 was clearly characterized by elevated D-dimer levels on admission, reflecting enhanced COVID-19 related thrombogenicity.
A prospective study on the incidence of postponed time-sensitive urological procedures during the SARS-CoV-2 pandemic due to patient preference	McDermott,  A,  O'Kelly, et al	Ir J Med Sci	Healthcare Response | Réponse des soins de santé	Investigate the incidence of postponed, medically necessary, time-sensitive urological procedures due to a patient’s unwillingness to proceed to a recommended surgical intervention during the first phase of the SARS-CoV-2 pandemic in Ireland. The incidence for patients postponing urological procedures due to the risk of acquiring nosocomial SARS-CoV-2 is 10%. Endourological procedures for urolithiasis are the most frequently postponed procedures by patients. This study demonstrates that a subset of patients will decline urgent urological surgery during the SARS-CoV-2 pandemic.
Compassionate use of remdesivir in children with COVID-19	Méndez-Echevarría,  A,  Pérez-Martínez, et al	Eur J Pediatr	Clinical data| Données cliniques	A nationwide multicenter observational study was conducted on children with confirmed SARS-CoV-2 receiving compassionate treatment with Remdesivir RDV in Spain.  In the cohort, most of the patients achieved successful clinical outcome, without observing adverse events, as such the authors call for clinical trials of RDV therapy for children with COVID-19.
Effect of the COVID-19 Lockdown on Disease Recognition and Utilization of Healthcare Services in the Older Population in German: A Cross-sectional Study	Michalowsky,  B,  Hoffmann, et al	Age Ageing	Healthcare Response | Réponse des soins de santé	We aimed to describe the utilization of physician consultations, specialist referrals, hospital admissions, and the recognition of incident diseases in Germany for the older population during the COVID-19 lockdown. Physician consultations decreased in April and May 2020 compared to the same periods in 2019. Volumes of hospital admissions decrease earlier and more intensely than physician consultations. Diabetes, dementia, depression, cancer, and stroke were diagnosed less frequently during the lockdown, meaning that the decrease in the recognition of diseases was greater than the decrease in physician consultations.
Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses	Mick,  E,  Kamm, et al	Nat Commun	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology | Immunologie	Here, we examine the upper airway host transcriptional response in patients with COVID-19 with other acute respiratory illnesses (ARIs). Compared with other viral ARIs, COVID-19 is characterized by a pronounced interferon response but attenuated activation of other innate immune pathways, including toll-like receptor, interleukin and chemokine signaling.  We further use machine learning to build 27-, 10- and 3-gene classifiers that differentiate COVID-19 from other ARIs with AUROCs of 0.981, 0.954 and 0.885, respectively.
A Methodology Based on Deep Q-Learning/Genetic Algorithms for Optimizing COVID-19 Pandemic Government Actions	Miralles-Pechuán,  L,  Jiménez, et al		Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	We implement the SEIR epidemiological model to represent the evolution of the COVID-19 virus on the population. To optimize the best sequences of actions governments can take, we propose a methodology with two approaches, one based on Deep Q-Learning and another one based on Genetic Algorithms. The sequences of actions (confinement, self-isolation, two-meter distance or not taking restrictions) are evaluated according to a reward system focused on meeting two objectives: firstly, getting few people infected so that hospitals are not overwhelmed, and secondly, avoiding taking drastic measures which could cause serious damage to the economy.
Lessons learnt from COVID-19 in Adult Congenital Heart Patient in Tehran: A survey-based study of prevention, exposure, susceptibility, and outcomes	Mohammadzadeh,  S,  Mehrakizadeh, et al	Cardiol Young	Epidemiology| Épidémiologie Clinical data| Données cliniques Public Health response| Interventions de santé publique	The aim of the study is to report the Tehran experience with respect to preventative self-care measures, disease exposure, susceptibility and outcomes after COVID-19 infection in adults with congenital heart disease (ACHD) patients. 309 ACHD patients were assessed. 67.3% of patients practiced high level preventative self-care measures. After community exposure, 33.3% developed COVID-19, and after household exposure 43.7% developed COVID-19. There was only 1 mortality in a post-operative patient. Age  and contact with confirmed COVID-19 cases were independently associated with COVID-19 infection.
U-shaped-aggressiveness of SARS-CoV-2: Period between initial symptoms and clinical progression to COVID-19 suspicion. A population-based cohort study	Morgenstern-Kaplan,  Dan,  Buitano-Tang, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objective of this cohort study was to determine the aggressiveness of SARS-CoV-2 using symptom progression in COVID-19 patients. We measured the period between initial symptoms and clinical progression to COVID-19 suspicion (PISYCS) and compared it to the primary outcomes (mortality and pneumonia) in Mexican patients. 65,500 patients were included. Reported fatalities and pneumonia were 3.32%, and 17.66%, respectively. According to the PISYCS, patients were distributed as follows: 14.89% in <24 hours, 43.25% between 1-3 days, 31.87% between 4-7 days and 9.97% >7 days. The distribution for mortality and pneumonia was 5.2% and 22.5% in <24 hours, 2.5% and 14% between 1-3 days, 3.6% and 19.5% between 4-7 days, 4.1% and 20.6% >7 days, respectively (p<0.001).
PMC7598305; Inflammatory Biomarker Trends Predict Respiratory Decline in COVID-19 Patients	Mueller,  AA,  Tamura, et al	Cell Rep Med	Epidemiology| Épidémiologie Clinical data| Données cliniques	In this single-center, retrospective cohort analysis of hospitalized coronavirus disease 2019 (COVID-19) patients, we investigate whether inflammatory biomarker levels predict respiratory decline in patients who initially present with stable disease.  Our work shows that rising CRP predicts subsequent respiratory deterioration in COVID-19.
Effect of Vitamin D3 Supplementation vs Placebo on Hospital Length of Stay in Patients with Severe COVID-19: A Multicenter, Double-blind, Randomized Controlled Trial	Murai,  IgorH,  Fernandes, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique RCT	The objective of this multicenter, double blind, randomized, placebo controlled trial was to investigate the efficacy and safety of vitamin D3 supplementation in patients with severe COVID-19. The analysis included 232 hospitalized patients with severe COVID-19. Among hospitalized patients with severe COVID-19, vitamin D3 supplementation was safe and increased 25-hydroxyvitamin D levels, but did not reduce hospital length of stay or any other relevant outcomes vs placebo. This trial does not support the use of vitamin D3 supplementation as an adjuvant treatment of patients with COVID-19.
Age-structured Impact of Mitigation Strategies on COVID-19 Severity and Deaths in Kenya	Mwalili,  Samuel,  Kimathi, et al	Research Square prepub	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	We developed age-structured model for describing the COVID-19 pandemic in Kenya under different non-pharmaceutical interventions. The peak dates for unmitigated (UM), the 45% NPI (M45) and School closure-curfew-partial lockdown NPI (SCL) are May 21st, October 17th and December 13th 2020, respectively. Their respective cumulative infections peaks are 43M, 24M and 25M. The daily reported severe cases, critical cases and death proportionately increased with age.
Comparative analysis of antibody- and lipid-based multiplexing methods for single-cell RNA-seq	Mylka,  Viacheslav,  Aerts, et al	bioRxiv	Clinical data| Données cliniques Immunology | Immunologie	Here, we compare the hashing performance of TotalSeq-A and -C antibodies, custom synthesized lipids and MULTI-seq lipid hashes in four cell lines, both for single-cell RNA-seq and single-nucleus RNA-seq. Antibody hashing was evaluated on clinical samples using PBMCs from healthy and SARS-CoV-2 infected patients, where we demonstrate a more affordable approach for large single-cell sequencing clinical studies, while simultaneously reducing batch effects.
Perceptions of immunity and vaccination certificates among the general population: a nested study within a serosurvey of anti-SARS-CoV-2 antibodies (SEROCoV-POP)	Nehme,  M,  Stringhini, et al	Swiss Med Wkly	Public Health response| Interventions de santé publique	Our objective was to determine social and individual perceptions of COVID-19 immunity certificates through a population-based study.  This study shows that the general adult population in Geneva, Switzerland can envisage scenarios where COVID-19 immunity, and eventually vaccination, certificates would be useful. Provided an effective vaccine was available, 55% of participants agreed that vaccination should be mandatory and 49% agreed that a vaccination certificate should be mandatory.
Central and peripheral nervous system complications of COVID-19: A prospective tertiary center cohort with 3-month follow-up	Nersesjan,  Vardan,  Amiri, et al	medRxiv	Clinical data| Données cliniques	The objective of this prospective observational study was to systematically describe central and peripheral nervous system (CNS and PNS) complications in hospitalized COVID-19 patients. From April-September 2020, we enrolled 61 consecutively admitted COVID-19 patients, 35 (57%) of whom were referred to ICU for respiratory failure. Evaluation revealed a higher frequency of CNS/PNS symptoms in ICU patients compared to non-ICU patients. The most common CNS and PNS complications were encephalopathy and critical illness polyneuromyopathy, respectively. Cerebrospinal fluid was negative for SARS-CoV-2 RNA in all 5 patients investigated.
Genetic diversity of SARS-CoV-2 and clinical, epidemiological characteristics of COVID-19 patients in Hanoi, Vietnam	Nguyen,  TT,  Pham, et al	PLoS One	Epidemiology| Épidémiologie Clinical data| Données cliniques Coronavirology| Coronavirologie	We describe 44 SARS-CoV-2 RT-PCR positive patients admitted to a hospital in Hanoi between March 6 and April 15 2020. Forty-one cases had symptoms at admission, typically dry cough, fever, sore throat and diarrhoea. All SARS-CoV-2 genomes were similar to the reference sequence Wuhan_1, and 32 strains belonged to the B.1.1 lineage. The three most common variants were linked, and included C3037T, C14408T (nsp12: P323L) and A23403G (S: D614G) mutations. This group of mutations often accompanied variant C241T (39/44 genomes) or GGG 28881..28883 AAC (33/44 genomes). The prevalence of the former reflected probable European origin of viruses, and the transition D614G was dominant in Vietnam. New variants were identified; however, none could be associated with disease severity.
Health-care organization for the management and surveillance of SARS-CoV-2 infection in children during pandemic in Campania region, Italy	Nunziata,  F,  Bruzzese, et al	Ital J Pediatr	Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	The management of children with suspected or confirmed COVID-19 needs to be appropriately targeted. We designed a hub-and-spoke system to provide healthcare indications based on the use of telemedicine and stringent admission criteria, coordinate local stakeholders and disseminate information. Between March 24th and September 24th 2020, the Hub Centre managed a total of 208 children, of which 104 (50%) received a final diagnosis of SARS-CoV-2 infection. Application of stringent criteria for hospital admission based on clinical conditions, risk factors and respect of biocontainment measures, allowed to manage the majority of cases (74, 71.1%) through telemedicine. Thirty children (28%) were hospitalized.
Professional Quality of Life and Perceived Stress in Health Professionals before COVID-19 in Spain: Primary and Hospital Care	Ortega-Galán Á,  M,  Ruiz-Fernández, et al	Healthcare (Basel)	Mental Health | santé mentale	This study aimed to analyze the professional quality of life and the perceived stress of health professionals before COVID-19 in Spain, in primary and hospital care professionals. A cross-sectional observational study on health professionals working in health centers during the health crisis caused by COVID-19 was conducted. A total of 537 professionals participated, both in hospital care (54.7%) and in primary care (45.3%). When primary care participants were grouped by profession, significant differences were found in relation to perceived stress and to the three subscales of professional quality of life. In hospital care, the differences were observed when comparing compassion fatigue and perceived stress by gender. The COVID-19 health crisis has had an impact on mental health and the quality of professional life of health professionals.
Detection of SARS-CoV-2 from Patient Fecal Samples by Whole Genome Sequencing	Papoutsis,  Andreas,  Borody, et al	Research Square prepub	Coronavirology| Coronavirologie	Here were sought to identify SARS-CoV-2 by enrichment NGS from fecal samples, and to utilize whole genome analysis to characterize SARS-CoV-2 mutational variations in COVID-19 patients. Study participants underwent testing for SARS-CoV-2 from fecal samples by whole genome enrichment NGS (n = 14), and RT-PCR nasopharyngeal swab analysis (n = 12). The concordance of SARS-CoV-2 detection by enrichment NGS from stools with RT-PCR nasopharyngeal analysis was 100%. Unique variants were identified in four patients, with a total of 33 different mutations among those in which SARS-CoV-2 was detected by whole genome enrichment NGS. These results highlight the potential viability of SARS-CoV-2 in feces, its ongoing mutational accumulation, and its possible role in fecal-oral transmission.
Computational investigation of binding of chloroquinone and hydroxychloroquinone against PLPro of SARS-CoV-2	Patel,  D,  Athar, et al	J Biomol Struct Dyn	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	This study carried out molecular docking and dynamics simulation studies of FDA approved Chloroquine (CQ)and Hydroxychloroquine (HCQ)against SARS-CoV-2 Papain-like proteases (PLpro). The end aim is to characterise the binding mode of CQ and HCQ and identify the key amino acid residues involved in the mechanism of action. Further, molecular dynamics simulations (MDS) were carried out with the docked complex to search for the conformational space and for understanding the integrity of binding mode. We showed that the CQ and HCQ can bind with better binding affinity with PLpro as compared to reference known PLpro inhibitor. Based on the presented findings, it can be anticipated that the SARS-CoV-2 PLpro may act as molecular target of CQ and HCQ, and can be projected for further exploration to design potent inhibitors of SARS-CoV-2 PLpro in the near future.
Machine Learning Based Predictors for COVID-19 Disease Severity	Patel,  Dhruv,  Kher, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques	Predictors of the need for intensive care and mechanical ventilation can help healthcare systems in planning for surge capacity for COVID-19. We used socio-demographic data, clinical data, and blood panel profile data at the time of initial presentation to develop machine learning algorithms for predicting the need for intensive care and mechanical ventilation. Among the algorithms considered, the Random Forest classifier performed the best with AUC = 0.80 for predicting ICU need and AUC = 0.82 for predicting the need for mechanical ventilation. We also determined the most influential features in making this prediction, and concluded that all three categories of data are important. Finally, we determined the relative importance of blood panel profile data and noted that the AUC dropped by 0.12 units when this data was not included, thus indicating that it provided valuable data in predicting disease severity.
Suspected Heparin-Induced Thrombocytopenia in a COVID-19 Patient on Extracorporeal Membrane Oxygenation Support: A Case Report	Phan,  XuanT,  Nguyen, et al	Research Square prepub	Clinical data| Données cliniques	In this report, we present a case of a COVID-19 patient on Extracorporeal membrane oxygenation (ECMO) support who was diagnosed with Heparin-induced thrombocytopenia (HIT.)and required intensive treatment. Initially, HIT was only suspected due to newly-developed thrombocytopenia and oxygenator dysfunction, with thrombi observed later. Regarding his treatment, since there was no recommended replacement to heparin available to us at the time of diagnosis, we decided to use rivaroxaban temporarily. No adverse events were recorded during that period. The patient was able to make a full recovery.
Increasing Traumatic Brain Injury Incidence during COVID-19 Pandemic in the Emergency Department of Cipto Mangunkusumo National General Hospital-A National Referral Hospital in Indonesia	Prawiroharjo,  P,  Pangeran, et al	Neurology	Healthcare Response | Réponse des soins de santé	Retrospective study comparing  traumatic brain injury (TBI) incidence before and during COVID-19 pandemic era starting from the declaration of national pandemic date (March 16, 2020) until June 14, 2020 with the comparison of the same period in the previous year. There was an increase in admission rate due to TBI during COVID-19 pandemic compared with the previous year (157/752 (20.9%) vs 106/766 (13.8%), p < 0.001, respectively). During the pandemic era, road traffic injury (97/157 (61.8%) vs 56/106 (52.8%), p = 0.149) as well as moderate-to-severe brain injury tended to increase (30/157 (19.1%) vs 17/106 (16.0%) p = 0.524) albeit statistically insignificant. TBI incidence remained increasing despite entering the COVID-19 era.
Clinical and serological profile of asymptomatic and non-severe symptomatic COVID-19 cases: Lessons from primary care in Latin America	Puschel,  K,  Ferreccio, et al	BJGP Open	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology | Immunologie	The aim of this study is to assess the effectiveness of rapid serologic testing in detection and surveillance of Covid-19 cases in primary care. Longitudinal study based on non-random sample of 522 participants including 304 symptomatic patients and 218 high-risk asymptomatic individuals receiving care at four primary health clinics in an underserved area in Santiago. Participants were systematically assessed and tested for Covid-19 with RT-PCR and serology at baseline and followed clinically and serologically for a three weeks period. The prevalence rate of RT-PCR confirmed Covid-19 cases was 3.5 times higher in symptomatic patients (27.5% (22.1-32.8; 95% CI) compared to asymptomatic participants (7.9% (4.3-11.6; 95% CI). Sensitivity of serologic testing was 57.8% (44.8-70.1; 95% CI) during the third week of follow-up and specificity was 98.4% (95.5-99.7; 95% CI). Rapid serologic testing is ineffective for detecting asymptomatic or non-severe cases of COVID-19 at early stages of the disease but can be of value for surveillance of immunity response in primary care.
In silico screening and molecular dynamics of phytochemicals from Indian cuisine against SARS-CoV-2 M(Pro)	Rajendran,  M,  Roy, et al	J Biomol Struct Dyn	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	In the present study, phytochemicals from spices were assessed for their ability to interact with SARS-CoV-2 M(Pro). Structure based virtual screening was performed with 146 phytochemicals from spices using Autodock Vina. Phytochemicals with binding energy ≥ -8.0 kcal/mol were selected to understand their interaction with M(Pro). Virtual screening was further validated by performing molecular docking to generate favorable docked poses and the participation of important amino acid residues. The finding shows that cinnamtannin B2 and cyanin showed favorable binding affinity values with SARS-CoV-2 M(Pro). The results are comparable in terms of docked poses, important amino acid participation and thermodynamic properties with the standard control drugs remdesivir, benazepril and hydroxychloroquine diphosphate. The results computed using Prime MM-GBSA show that cinnamtannin B2 (-68.54940214 kcal/mol) and cyanin (-62.1902835 kcal/mol) have better binding affinity in comparison to hydroxychloroquine diphosphate (-54.00912412 kcal/mol) and benazepril (-53.70242369 kcal/mol).
COVID-19 Pandemic: India is Heading Towards the First Place	Ramasamy,  Dr Kannamani	SSRN- Lancet prepublication	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	The objective of this research paper is to explore the current state of COVID-19 pandemic of India and the USA and understand how the COVID-19 spread is severe in India. The secondary aim of the research is to predict the confirmed cases and death rates for the forthcoming days for the USA and India as well and conclude India’s future state in COVID-19. For this research, we have used the data from 20 January 2020 to 13 October 2020 from the World Health Organization. To forecast the COVID-19 cumulative confirmed and death cases for the United States America and India, we have used FORECAST.ETS function in Microsoft Excel. The prediction calculated till 31 December 2020. By 31 Oct 2020, the forecasted cumulative cases would be 8569864 in the USA and India, it would be 8288117 approximately. By 27 Nov 2020, the forecasted cumulative cases would be 9930000 in the USA and India, it would be 9941491 approximately. By 31 Dec 2020, the forecasted cumulative cases would be 11642764 in the USA and India, it would be 12023517 approximately. So, by the last week of November, India will have more COVID-19 cases than the USA and hence India will take first place globally. Along with the guidelines and advisory from WHO, the government of India and the department of health is taking various initiatives to control the COVID-19 spread and maintain the lower number of COVID-19 cases. However, the number of confirmed and death rates are increasing in an uncontrolled manner in the Indian subcontinent.
Political Partisanship and Anti-Science Attitudes in Online Discussions about Covid-19	Rao,  Ashwin,  Morstatter, et al	arXiv	Public Health response| Interventions de santé publique	Here, we use social media data to study complexity of polarization. We analyze a large dataset of tweets related to the pandemic collected between January and May of 2020, and develop methods to classify the ideological alignment of users along the moderacy (hardline vs moderate), political (liberal vs conservative) and science (anti-science vs pro-science) dimensions. While polarization along the science and political dimensions are correlated, politically moderate users are more likely to be aligned with the pro-science views, and politically hardline users with anti-science views. Contrary to expectations, we do not find that polarization grows over time; instead, we see increasing activity by moderate pro-science users. We also show that anti-science conservatives tend to tweet from the Southern US, while anti-science moderates from the Western states.
An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19	Rappazzo,  CG,  Tse, et al	bioRxiv	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Here, we employed a directed evolution approach to engineer three SARS-CoV-2 antibodies for enhanced neutralization breadth and potency. One of the affinity-matured variants, ADG-2, displays strong binding activity to a large panel of sarbecovirus receptor binding domains (RBDs) and neutralizes representative epidemic sarbecoviruses with remarkable potency. Structural and biochemical studies demonstrate that ADG-2 employs a unique angle of approach to recognize a highly conserved epitope overlapping the receptor binding site. In murine models of SARS-CoV and SARS-CoV-2 infection, passive transfer of ADG-2 provided complete protection against respiratory burden, viral replication in the lungs, and lung pathology. Altogether, ADG-2 represents a promising broad-spectrum therapeutic candidate for the treatment and prevention of SARS-CoV-2 and future emerging SARS-like CoVs.
Impact of Coronavirus Disease 2019 Pandemic on the Incidence and Management of Out-of-Hospital Cardiac Arrest in Patients Presenting With Acute Myocardial Infarction in England	Rashid Hons,  M,  Gale Hons, et al	J Am Heart Assoc	Healthcare Response | Réponse des soins de santé	Acute myocardial infarction hospitalizations with OHCA during the COVID-19 period (February 1-May 14, 2020) from the Myocardial Ischaemia National Audit Project and British Cardiovascular Intervention Society data sets were analyzed. Acute myocardial infarction hospitalizations during COVID-19 period were reduced by >50% (n=20 310 versus n=9325). OHCA was more prevalent during the COVID-19 period compared with the pre-COVID-19 period (5.6% versus 3.6%), with a 56% increase in the incidence of OHCA (IRR, 1.56; 95% CI, 1.39-1.74). The overall rates of invasive coronary angiography (58.4% versus 71.6%; P<0.001) were significantly lower among the OHCA group during COVID-19 period with increased time to reperfusion (mean, 2.1 versus 1.1 hours; P=0.05) in those with ST-segment-elevation myocardial infarction.
Natural Compounds as Inhibitors of SARS-CoV-2 Main Protease (3CLpro): A Molecular Docking and Simulation Approach to Combat COVID-19	Rehman,  MT,  AlAjmi, et al	Curr Pharm Des	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	We have adopted a computational approach to identify lead molecules from nature. Ligands from natural compounds library available at Selleck Inc (L1400) have been screened for their ability to bind and inhibit the main protease (3CLpro) of SARS-CoV-2. We found that Kaempferol, Quercetin, and Rutin were bound at the substrate binding pocket of 3CLpro with high affinity (105-106 M-1) and interact with the active site residues such as His41 and Cys145 through hydrogen bonding and hydrophobic interactions. The results suggest that natural compounds such as flavonoids have the potential to be developed as novel inhibitors of SARS-CoV-2 with a comparable/higher potency as that of Remdesivir. Their clinical usage on COVID-19 patients is a subject of further investigations and clinical trials.
Is the Frequency of Candidemia Increasing in COVID-19 Patients Receiving Corticosteroids?	Riche,  CVW,  Cassol, et al	J Fungi (Basel)	Epidemiology| Épidémiologie Clinical data| Données cliniques	Corticosteroids have potent anti-inflammatory and immunosuppressive effects. Recently, these medications have gained importance in the treatment of severe COVID-19. Here we present data demonstrating a marked (10-fold) increase in frequency of candidemia in hospitalized patients with COVID-19 receiving corticosteroids in Brazil. Overall mortality was 72.7%, despite antifungal therapy. Physicians should be aware of the potential risk for candidemia among severely ill COVID-19 patients receiving high-doses of corticosteroids.
Profiles of sleep changes during the COVID-19 pandemic: Demographic, behavioural and psychological factors	Robillard,  R,  Dion, et al	J Sleep Res	Mental Health | santé mentale	This study aimed to evaluate changes in sleep during the COVID-19 outbreak, and used data-driven approaches to identify distinct profiles of changes in sleep-related behaviours. Demographic, behavioural and psychological factors associated with sleep changes were also investigated. In 5,525 Canadian respondents (67.1% females, 16-95 years old: Mean ± SD = 55.6 ± 16.3 years), wake-up times were significantly delayed relative to pre-outbreak estimates (p < .001, ηp2 = 0.04). Occurrences of clinically meaningful sleep difficulties significantly increased from 36.0% before the outbreak to 50.5% during the outbreak (all p < .001, g ≥ 0.27). The emergence of new sleep difficulties was independently associated with female sex, chronic illnesses, being employed, family responsibilities, earlier wake-up times, higher stress levels, as well as heavier alcohol use and television exposure.
Racial and Ethnic Differences in Presentation and Outcomes for Patients Hospitalized with COVID-19: Findings from the American Heart Association's COVID-19 Cardiovascular Disease Registry	Rodriguez,  F,  Solomon, et al	Circulation	Epidemiology| Épidémiologie Clinical data| Données cliniques	We sought to identify racial/ethnic differences in presentation and outcomes for patients hospitalized with COVID-19. Among 7,868 patients hospitalized with COVID-19, 33.0% were Hispanic, 25.5% were non-Hispanic Black, 6.3% were Asian, and 35.2% were non-Hispanic White. Hispanic and Black patients were younger than non-Hispanic White and Asian patients and were more likely to be uninsured. Black patients had the highest prevalence of obesity, hypertension, and diabetes. Black patients also had the highest rates of mechanical ventilation (23.2%) and renal replacement therapy (6.6%) but the lowest rates of remdesivir use (6.1%). Overall mortality was 18.4% with 53% of all deaths occurring in Black and Hispanic patients. The adjusted odds ratios (ORs) for mortality were 0.93 (95% confidence interval CI] 0.76-1.14) for Black patients, 0.90 (95% CI 0.73-1.11) for Hispanic patients, and 1.31 (95% CI 0.96-1.80) for Asian patients compared with non-Hispanic White patients. The median OR across hospitals was 1.99 (95% CI 1.74-2.48). Asian patients had the highest COVID-19 cardiorespiratory severity at presentation (adjusted OR 1.48, 95% CI 1.16-1.90).  Black and Hispanic patients bore a greater burden of mortality and morbidity due to their disproportionate representation among COVID-19 hospitalizations.
Early Percutaneous Tracheostomy in Coronavirus Disease 2019: Association With Hospital Mortality and Factors Associated With Removal of Tracheostomy Tube at ICU Discharge. A Cohort Study on 121 Patients	Rosano,  A,  Martinelli, et al	Crit Care Med	Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	Aim of the study was to analyze the hospital mortality of coronavirus disease 2019 patients who had received early percutaneous tracheostomy and factors associated with removal of tracheostomy cannula at ICU discharge. One-hundred and twenty-one patients (74%) were tracheostomized, whereas the other 43 (26%) were managed with translaryngeal intubation only. In multivariable analysis, early percutaneous tracheostomy was associated with lower hospital mortality. Sixty-six of tracheostomized patients (55%) were discharged alive from the hospital. Age and male sex were the only characteristics that were independently associated with mortality in the tracheostomized patients (45.5% and 62.8% in tracheostomized and nontracheostomized patients, respectively; p = 0.009). Tracheostomy tube was removed in 47 of the tracheostomized patients (71%). The only variable independently associated with weaning from tracheostomy at ICU discharge was a faster start of spontaneous breathing after tracheotomy was performed.
Behavioral Changes During COVID-19 Confinement in France: A Web-Based Study	Rossinot,  H,  Fantin, et al	Int J Environ Res Public Health	Mental Health | santé mentale Public Health response| Interventions de santé publique	The objective of this study was to understand what the determinants of the changes in participants' behavior and mental state were during the confinement. In total, 28.7% reported having a more balanced diet, against 17.1% with a less balanced diet, 22.7% of respondents reported an increased alcohol consumption, as opposed to only 12.2% declaring a decrease, and 11.2% of respondents increased their tobacco consumption, while 6.3% decreased it. In total, 50.6% of the participants reported being more depressed, stressed, or irritable since the beginning of the lockdown. Confinement had a negative effect on every behavior studied in this survey, except for nutrition. We also found that negative mental state changes were strongly associated with nutrition, sleep, physical activity and alcohol consumption changes.
The Demand for Elective Neurosurgery at a German University Hospital during the First Wave of COVID-19	Rupa,  R,  Sass, et al	Healthcare (Basel)	Healthcare Response | Réponse des soins de santé	This single-center retrospective study aims to analyze temporal relationships of the first wave of the COVID-19 pandemic in Germany with the number of patients who sought and received elective neurosurgical treatment at a German university hospital. The beginning of the COVID-19 pandemic was correlated to an immediate and significant decrease in ON, and to a significant decrease in the number of EP performed. The subsequent increase in ON was delayed. Adequate measures to promote timely discharge of patients may become increasingly relevant as the pandemic proceeds.
The effect of novel coronavirus disease-2019 (COVID-19) on fibromyalgia syndrome	Salaffi,  F,  Giorgi, et al	Clin Exp Rheumatol	Epidemiology| Épidémiologie Clinical data| Données cliniques	The aim of this study was to observe the behaviour of fibromyalgia (FM) symptoms during the course of COVID-19. Eight hundred and ninety-seven (93%) of the 965 patients (881 women 91.3%] and 84 men 8.7%]) were followed up on an outpatient basis because of FM and 68 (7.0%) were either followed up as out-patients or hospitalised because of COVID-19. The major differences between the score of the items (those with the greatest disease impact) were the following related symptoms: sleep quality (FIQR15), fatigue/energy (FIQR13), pain (FIQR12), stiffness (FIQR14). The mean total and subdomain scores of all the tests were significantly higher in the patients with COVID-19, which suggests that global FM symptoms are more severe in patients with infection.
Chest CT in the Emergency Department for Diagnosis of COVID-19 Pneumonia: Dutch Experience	Schalekamp,  S,  Bleeker-Rovers, et al	Radiology	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	To assess the real-life performance of radiologist emergency department chest CT interpretation for diagnosing COVID-19 during the acute phase of the pandemic, using the COVID-19 reporting and data system (CO-RADS). A total of 1070 patients (median age 66, IQR 54-75, 626 men) were included, of whom 536/1070 (50%) had a positive RT-PCR, 137/1070 (13%) patients were considered to have a possible or probable COVID- 19 based on the clinical reference standard. Chest CT yielded an AUC of 0.87 (95%CI 0.84-0.89) compared with RT-PCR and 0.87 (95%CI 0.85-0.89) compared with the clinical reference standard. A CO-RADS score ≥4 yielded an OR of 25.9 (95%CI 18.7-35.9) for a COVID-19 diagnosis by RT-PCR, and an OR of 30.6 (95%CI 21.1-44.4) by the clinical reference standard. For symptom duration of less than 48 hours, the AUC fell to 0.71 (95%CI 0.62-0.80; P<.001). Chest CT analysis using the COVID-19 reporting and data system (CO-RADS) enables rapid and reliable diagnosis of COVID-19, particularly when symptom duration is greater than 48 hours.
The total number and mass of SARS-CoV-2 virions in an infected person	Sender,  Ron,  Bar-On, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Coronavirology| Coronavirologie	We integrate the best current knowledge about the abundance of potential SARS-CoV-2 host cells and typical concentrations of virions in bodily fluids to estimate the total number and mass of SARS-CoV-2 virions in an infected person. Knowledge of the absolute number of virions in an infected individual can put into perspective parameters of the immune system response, minimal infectious doses and limits of detection in testing.
Assessing preventive health behaviors from COVID-19: a cross sectional study with health belief model in Golestan Province, Northern of Iran	Shahnazi,  H,  Ahmadi-Livani, et al	Infect Dis Poverty	Public Health response| Interventions de santé publique	The present study aimed to determine the preventive behaviors from the disease based on constructs of the health belief model. Results of the present study indicated that female gender, perceived barriers, perceived self-efficacy, fatalistic beliefs, perceived interests, and living in city had the greatest preventive behaviors from COVID-19 respectively. Preventive interventions were necessary among males and villagers.
PMC7441069; Acute upper limb ischemia as the first manifestation in a patient with COVID-19	Shao,  T,  In-Bok Lee, et al	J Vasc Surg Cases Innov Tech	Clinical data| Données cliniques	We report a case of acute upper extremity ischemia as the initial clinical presentation of a patient with COVID-19.
PMC7661558; COVID-19 anxiety scale (CAS): Development and psychometric properties	Silva,  WAD,  de Sampaio Brito, et al	Curr Psychol	Mental Health | santé mentale	The objective of the present research is to develop and validate the COVID-19 Anxiety Scale (CAS). Three studies to gather evidence regarding content and construct validity, as well to evaluate the reliability of the measure. Results demonstrate that CAS is a reliable and adequate instrument to assess COVID-19 related anxiety.
Computational investigation for identification of potential phytochemicals and antiviral drugs as potential inhibitors for RNA-dependent RNA polymerase of COVID-19	Singh,  J,  Malik, et al	J Biomol Struct Dyn	Therapeutics| Thérapeutique	In the present study, we have used the insilico approach for the prediction of novel drug molecules that can be best target the RNA-dependent RNA-polymerase (Pol/RdRp) protein of SARS-CoV-2. Three antiviral and three phyto-chemicals were further evaluated in molecular dynamics studies.
Prevalence of Posttraumatic Stress Disorder and Depression in General Population in India During COVID-19 Pandemic Home Quarantine	Singh,  SP,  Khokhar, et al	Asia Pac J Public Health	Mental Health | santé mentale	A web-based survey was conducted using Google Forms during April 2020 home quarantine. A prevalence of 28.2% for PTSD and 14.1% for depression was observed. A significant (P < .05) association was reported between depression and number of household members, and between depression and occupation (P<.001).
Computational Design of 25-mer Peptide Binders of SARS-CoV-2	Sitthiyotha,  T,  Chunsrivirot, et al	J Phys Chem B	Therapeutics| Thérapeutique	This study developed an approach to design SARS-CoV-2 recptor binding domain (RBD) 25-mer peptide binders, and these peptides may be promising candidates as potential SARS-CoV-2 inhibitors.
PMC7405484; Third-trimester placentas of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive women: histomorphology, including viral immunohistochemistry and in-situ hybridization	Smithgall,  MC,  Liu-Jarin, et al	Histopathology	Clinical data| Données cliniques	The aim of our study, in addition to describing histomorphology, was to utilize in‐situ hybridization (ISH) for the S‐gene encoding the spike protein and immunohistochemistry (IHC) with the monoclonal SARS‐CoV‐2 spike antibody 1A9 for placental evaluation.  Evidence of maternal-fetal vascular malperfusion was identified, with placentas from SARS-CoV-2-positive women being significantly more likely to show villous agglutination (P = 0.003) and subchorionic thrombi (P = 0.026) than placentas from SARS-CoV-2-negative women. No evidence of direct viral involvement was identified with ISH and IHC.
Maturation and persistence of the anti-SARS-CoV-2 memory B cell response	Sokal,  Aurelien,  Chappert, et al	bioRxiv	Clinical data| Données cliniques Immunology | Immunologie	We report here a longitudinal single-cell and repertoire profiling of the B cell response up to 6 months in mild and severe COVID-19 patients. Overall, these findings demonstrate that an antigen-driven activation persisted and matured up to 6 months after SARS-CoV-2 infection and may provide long-term protection.
Immunogenicity of one- and two-dose regimens of the Ad26.COV2.S COVID-19 vaccine candidate in adult and aged rhesus macaques	Solforosi,  Laura,  Kuipers, et al	bioRxiv	Vaccine Research| Recherche sur les vaccins Immunology | Immunologie Animal model | Modèle animal	Here we assessed the immunogenicity of one- and two-dose Ad26.COV2.S vaccine regimens in adult and aged non-human primates (NHP).  A second vaccine dose, administered 8 weeks post the first immunization, induced a significant increase in antigen-specific binding and neutralizing antibody responses in both adult and aged animals as compared to a single dose.
Student Body Temperature and Physical Distance Management Device in Classroom Using 3D Stereoscopic Distance Measurement	Soni,  Vishal Dineshkumar,  Soni, et al	SSRN- Lancet prepublication	Public Health response| Interventions de santé publique	We designed an Internet of Things (IoT) and Artificial intelligence based paradigm that makes use of object detection to assess the maintenance of  physical distance between students in Class room. To mitigate problems posed by overlapping images we a used stereoscopic distance measurement algorithm
Serological response and disease-specific neutralizing antibodies in kidney transplant recipients with SARS-CoV-2 infection – a case series	Speer,  Claudius,  Schnitzler, et al	Research Square prepub	Clinical data| Données cliniques Immunology | Immunologie	Immunocompromised kidney transplant recipients showed a functional serological response with disease-specific neutralizing antibodies upon SARS-CoV-2 infection that was sustained for 15 weeks..
High value of Mid-regional proAdrenomedullin in COVID-19: a marker of widespread endothelial damage, disease severity and mortality	Spoto,  S,  Agrò, et al	J Med Virol	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	The aim of this study was to evaluate the role of Mid‐regional proAdrenomedullin (MR‐proADM) as a marker of SARS CoV2‐related widespread endothelial damage, clinically identified by organs damage, disease severity and mortality. MR‐proADM values ≥ 2 nmol/l identify those patients with high mortality risk related to a multiorgan dysfunction syndrome.
Computational study of pomegranate peel extract polyphenols as potential inhibitors of SARS-CoV-2 virus internalization	Suručić,  R,  Tubić, et al	Mol Cell Biochem	Therapeutics| Thérapeutique	The results showed that the constituents of pomegranate peel extracts, namely punicalagin and punicalin had very promising potential for significant interactions with the selected protein targets
COVID-19 in HIV infected patients: A Case series and Literature Review	Swaminathan,  N,  Moussa, et al	J Med Virol	Clinical data| Données cliniques	This case-series reviews the clinical and laboratory characteristics of COVID in PLWH admitted in a community-hospital.
Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019	Sweeney,  TE,  Liesenfeld, et al	Crit Care Med	Clinical data| Données cliniques Immunology | Immunologie	The aim of this study was to test whether our predefined 33-messenger RNA bacterial endotype classifier recapitulates the same three clinical and immunological endotypes in coronavirus disease 2019: Adaptive, Coagulopathic, Inflammopathic .Adaptive patients had lower rates of sever respiratory failure and no deaths.
The values and limitations of mathematical modelling to COVID-19 in the world: a follow up report	Tang,  Y,  Tang, et al	Emerg Microbes Infect	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	Our original paper prepared in March 2020 analyzed the outbreaks of COVID-19 in the US and its selected states to identify the rise, peak, and decrease of cases within a given geographic population, as well as a rough calculation of accumulated total cases in this population from the beginning to the end of June 2020. The current report will describe how well the later actual trend from March to June fit our model and prediction. Similar analyses are also conducted to include countries other than the US. From such a wide global data analysis, our results demonstrated that different US states and countries showed dramatically different patterns of pandemic trend.
PMC7654299; Suicidal ideation among Bangladeshi university students early during the COVID-19 pandemic: Prevalence estimates and correlates	Tasnim,  R,  Islam, et al	Child Youth Serv Rev	Epidemiology| Épidémiologie Mental Health | santé mentale	This study aimed to assess suicidal ideation and associated factors among university students in Bangladesh during the early stages of the COVID-19 pandemic. Potential protective factors were being male, regular exercise, and good studies. Potential risk related to sleep, cigarette smoking, and prior/familial suicidality.
Immune suppression in the early stage of COVID-19 disease	Tian,  W,  Zhang, et al	Nat Commun	Clinical data| Données cliniques Immunology | Immunologie	Here we analyze urine samples from COVID-19 infection cases, healthy donors and non-COVID-19 pneumonia cases using quantitative proteomics. The molecular changes suggest that immunosuppression and tight junction impairment occur in the early stage of COVID-19 infection. Further subgrouping of COVID-19 patients into moderate and severe types shows that an activated immune response emerges in severely affected patients.
Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2	Touret,  Franck,  Driouich, et al	bioRxiv	Therapeutics| Thérapeutique	In this preprint,  we present the pre-clinical evaluation of Imatinib and other similar tyrosine kinase inhibitors (TKIs) targeting the Abelson kinase 2 against pathogenic coronaviruses in multiple models.  In vivo, Imatinib therapy failed to impair SARS-CoV-2 replication in a golden Syrian hamster model despite high concentrations in plasma and in the lung. Overall, these results do not support the use of Imatinib and similar TKIs as antivirals in the treatment of Covid-19.
Recovery, Restoration and Risk: A Cross Sectional Survey of the Impact of COVID-19 on General Practitioners in the First UK City to Lockdown	Trivedi,  N,  Trivedi, et al	BJGP Open	Mental Health | santé mentale	This study focuses on assessing the impact of COVID-19 on GPs in Leicestershire, the first UK city to lockdown locally. The COVID-19 prevalence in GPs was 8.1%. 79.3% of GPs felt supported by their practice but only 59.5% felt supported with mental health. GPs described feeling more stressed during the COVID-19 pandemic than they had been previously. National Health Service England should focus on GP stress and wellbeing as they work towards the restoration and recovery of primary care and prepare for a second peak.
Vulnerability and resilience in children during the COVID-19 pandemic	Tso,  WWY,  Wong, et al	Eur Child Adolesc Psychiatry	Mental Health | santé mentale	We conducted a large-scale cross-sectional population study of Hong Kong families with children aged 2–12 years using simple and multiple linear regression analyses to explore factors associated with child psychosocial problems and parental stress during the pandemic. This study identifies vulnerable groups of children and highlights the importance of strengthening family coherence, adequate sleep and exercise, and responsible use of electronic devices in promoting psychosocial wellbeing during the COVID-19 pandemic.
An Eye on the Future of COVID'19: Prediction of Likely Positive Cases and Fatality in India over A 30 Days Horizon using Prophet Model	Tulshyan,  V,  Sharma, et al	Disaster Med Public Health Prep	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&amp;eacute; publique	This study, using the Prophet Model, a time series analysis model, analyses the effects of COVID 19 based on Likely Positive Cases and fatality in India during and after the lockdown period from 24 March 2020 to 24 May 2020. Prediction depicts that during the lockdown, the total cases were rising but in a controlled manner with an accuracy of 87%. After the relaxation of lockdown rules, the predictions have shown an obstreperous situation with an accuracy of 60%.
A Predictive Internet-Based Model for COVID-19 Hospitalization Census	Turk,  PhilipJ,  Tran, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins de santé	Preprint. We propose a vector error correction model (VECM) for the number of COVID-19 patients in a healthcare system (Census) that incorporates Google search term activity and healthcare chatbot scores. The VECM provided a good fit to Census and very good forecasting performance as assessed by hypothesis tests and mean absolute percentage prediction error. We have demonstrated the VECM can potentially be a valuable component to a COVID-19 surveillance program in a healthcare system.
Detecting COVID-19 infection hotspots in England using large-scale self-reported data from a mobile application: a prospective, observational study	Varsavsky,  Thomas,  Graham, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	Preprint. We performed modelling on longitudinal, self-reported data from users of the COVID Symptom Study app in England between 24 March and 29 September, 2020. More than 2.8 million app users in England provided 120 million daily reports of their symptoms, and recorded the results of 170,000 PCR tests. Self-reported data from mobile applications can provide an agile resource to inform policymakers during a fast-moving pandemic, serving as an independent and complementary resource to more traditional instruments for disease surveillance.
An efficient mixture of deep and machine learning models for COVID-19 diagnosis in chest X-ray images	Wang,  D,  Mo, et al	PLoS One	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	The use of computer-aided diagnosis to screen X-ray images of COVID-19 cases can provide experts with auxiliary diagnosis suggestions, which can reduce the burden of experts to a certain extent. In this study, we first used conventional transfer learning methods, using five pre-trained deep learning models, and we propose an efficient diagnostic method that uses a combination of deep features and machine learning classification. Compared with the baseline Xception model, our proposed method has higher classification accuracy and efficient diagnostic performance.
Invasive Mechanical Ventilation May Be an Important Factor of Mortality in Severe/Critical COVID-19 Pneumonia: A Retrospective Cohort Study	Wei,  Jing,  Shi, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques	In this retrospective study, all inpatients confirmed severe or critical COVID-19 from two tertiary hospital in Huangshi were included, who had been discharged or died by March19,2020 (n=81). The univariable and multivariable logistic regression analysis was used to analyze the risk factors associated with in-hospital death. The proportion of coronary heart disease in non-survivors group was significantly higher than that in survivors group(26.9% vs 7.3%, P=0.032), but there were no differences in hypertension, diabetes and COPD between the non-survivors group and the survivors group. Multivariable logistic regression analysis showed increasing odds of in-hospital death associated with aspartate aminotransferase(AST) and invasive mechanical ventilation (IMV) (P<0.001)(P=0.017）.
Correlation of Body Mass Index (BMI), initial neutralizing antibodies (nAb), ABO group and kinetics of nAb and anti-nucleocapsid (NP) SARS-CoV-2 antibodies in convalescent plasma (CCP) donors – A longitudinal study with proposals for better quality of CCP	Wendel,  S,  Fontão-Wendel, et al	medRxiv	Clinical data| Données cliniques Therapeutics| Thérapeutique Immunology | Immunologie	Preprint. A cohort (n=78) of previously RT-PCR+ve (detected by nasopharyngeal swab during the acute phase), male convalescent patients, all with mild symptoms, were enrolled on serial blood sample collection for evaluation of longitudinal neutralizing antibody (nAb) titers and anti-nucleocapsid (NP) antibodies (IgM, IgG and IgA). Selection of convalescent plasma (CCP) donors for multiple collections based on initial high nAb titers (≥1280) or overweight/obese (BMI) provides a simple strategy to achieve higher quality in CCP programs. High IgG anti-NP levels can also be used as surrogate markers for high nAb screening.
Ecchymosis in critical coronavirus disease 2019 (COVID-19) patient in Tangerang, Indonesia: a case report	Widysanto,  A,  Wahyuni, et al	J Thromb Thrombolysis	Clinical data| Données cliniques	We present a case of ecchymosis in COVID-19-positive ICU hospitalized patient. The pathophysiology of ecchymosis in COVID-19 might be caused by microvascular injury and thrombosis, vasculitis, and disseminated intravascular coagulation (DIC). The presence of ecchymosis in COVID-19 patients is indicating an occuring coagulopathy and associated with increased mortality in COVID-19 infection.
Epidemiological and clinical characteristics of SARS-CoV-2 infection among healthcare workers in Hubei Province of China	Wu,  M,  Xie, et al	Infect Control Hosp Epidemiol	Epidemiology| Épidémiologie Clinical data| Données cliniques	This retrospective cohort study evaluated the epidemiological and clinical characteristics of SARS-CoV-2 infection among healthcare workers in Hubei Province, China. A total of 1,989 healthcare workers and 41,137 other occupational cases were included for analysis. Compared with COVID-19 cases in other occupational groups, healthcare workers with COVID-19 have half the risk of death, although they have been shown to have higher rates of fatigue and myalgia.
PMC7603991; Psychological effects of the COVID-19 pandemic on Wuhan's high school students	Yang,  D,  Swekwi, et al	Child Youth Serv Rev	Mental Health | santé mentale	This study explored the protective potential of resilience and positive emotion regulation against psychological trauma among Wuhan’s high school students during COVID-19. They found that psychological trauma was a negative predictor of mental health and this could be mitigated through resilience and positive emotion regulation.
The Development of a Novel Nanobody Therapeutic for SARS-CoV-2	Ye,  Gang,  Gallant, et al	bioRxiv	Therapeutics| Thérapeutique	This study tested a series of single-domain antibodies (nanobodies) that bind the SARS-CoV-2 spike protein receptor-binding domain (RBD). The top candidate (Nanosoat-1) tightly bound to the RBD, completely blocked ACE2 binding and neutralized SARS-CoV-2 infection in vitro and in vivo.
Comparison of the emergency and oncological surgery before and during the COVID-19 pandemic. A single-center retrospective study	Yiğit,  B,  Çitgez, et al	Ann Ital Chir	Healthcare Response | Réponse des soins de santé	This study aimed to identify changes and delays in diagnosis or treatment of malignancies during the COVID-19 pandemic (March 11 - May 31, 2020) in a single hospital in Italy. They observed that there was a progressive reduction in surgical activity March - May, 2020 and all types of oncological surgeries decreased significantly in the pandemic period compared to previous years.
PMC7661939; Innate and adaptive immunity of murine neural stem cell-derived piRNA exosomes/microvesicles against pseudotyped SARS-CoV-2 and HIV-based lentivirus	Yu,  B,  Ikhlas, et al	iScience	Immunology | Immunologie	Through testing pseudotyped SARS-CoV-2 lentiviral vectors, this study reports that exosomes/microvesicles (Ex/Mv) isolated from murine hypothalamic neural stem/progenitor cells have antiviral effects. The proposed mechanism of action is through cell-free innate antiviral responses that degrade the virus.
Association of SARS-CoV-2 genomic load trends with clinical status in COVID-19: A retrospective analysis from an academic hospital center in New York City	Zacharioudakis,  IM,  Zervou, et al	PLoS One	Clinical data| Données cliniques	This is a retrospective cohort study investigating the correlation between SARS-CoV2 viral load (assessed by Ct value) and clinical status (assessed using the Sequential Organ Failure Assessment (SOFA) score ) in adult patients with COVID-19 pneumonia in New York. 42 patients with at least 2 positive nasopharyngeal tests at least 24 hours were identified. 20 out of 42 patients had a lower SOFA score on their subsequent tests and and change in the Ct value associated with a decrease in SOFA score suggesting Ct value may be of prognostic value.
Patient satisfaction from ENT telephone consultations during the coronavirus disease 2019 pandemic	Zammit,  M,  Siau, et al	J Laryngol Otol	Healthcare Response | Réponse des soins de santé	This is a prospective questionnaire-based project assessing patient satisfaction with telephone ENT consultation before and after implementation of a structured consultations format during COVID-19 restrictions. 100 surveys were administered between April and June 2020 and a significant improvement in patient satisfaction was observed after implementation of structured consultation.
Global analysis of more than 50,000 SARS-CoV-2 genomes reveals epistasis between eight viral genes	Zeng,  HL,  Dichio, et al	Proc Natl Acad Sci U S A	Coronavirology| Coronavirologie	This study investigated whether the 50,000+ SARS-CoV2 genomes deposited in the Global Initiative on Sharing All Influenza Data (GISAID) repository show effects of epistatic contributions to fitness. The study identified eight significant epistatic interactions including viral genes ORF3a, ORF8, nsp2, nsp4, nsp6, nsp12, nsp13, and nsp14. Interacting sites may serve as a starting point to search for weaknesses of recombinant viral pathogens.
Spike-specific circulating T follicular helper cell and cross-neutralizing antibody responses in COVID-19-convalescent individuals	Zhang,  J,  Wu, et al	Nat Microbiol	Immunology | Immunologie	This study investigated antibody response after SARS-CoV2 infection in 67 convalescent patients. The majority of convalescent individuals maintained anti-spike S1- and S2-specific antibodies with neutralizing activity against pseudotyped virus, and that some of antibodies cross-neutralized SARS-CoV, MERS-CoV or both pseudotyped viruses. Convalescent individuals with severe COVID-19 showed higher neutralizing antibody titres and a higher frequency of CXCR3+ T follicular help (TFH) that were spike specific and positively associated with neutralizing antibody titres.
Research and Analysis of the Effect of Refined Nursing Intervention on COVID-19 Epidemic in Hemodialysis Center Runing Title:Effect of Refined Nursing Intervention on COVID-19 Epidemic	Zhang,  Qinglai,  Wang, et al	Research Square prepub	Mental Health | santé mentale Healthcare Response | Réponse des soins de santé	This study looked at the impact of a refined nursing intervention on depression and anxiety in hemodialysis patients who are at high risk of severe disease. The Symptom Checklist90 (SCL90) score was used to assess psychological state of 172 hemodialysis patients before, during and after dialysis. Depression and anxiety of patients were reduced after implementation of refined nursing intervention.
Epidemiological and clinical based study on four passages of COVID-19 patients: intervention at asymptomatic period contributes to early recovery	Zhang,  X,  Wang, et al	BMC Infect Dis	Clinical data| Données cliniques	This study investigated the impact of early treatment on 4 passages of SARS-CoV2, where a passage is defined as a linked transmission event. 78 patients were identified with 4 distinct passages. Early passages received treatment while symptomatic where late passages were treated asymptomatically. Significant decrease in several disease severity metrics were observed in the late passage/early treatment groups.
A continuously self-sterilizing form of copper capable of 99% SARS-CoV-2 deactivation in 30 seconds	Zinn,  AlfredA,  Izadjoo, et al	bioRxiv	Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)	This study describes a rapid-acting, self-sterilizing copper configuration capable of killing SARS-CoV-2 particles. The material maintains antimicrobial efficacy over consecutive uses and is shelf stable. The material could offer broad spectrum, non-selective defense against most microbes via integration into masks and other PPE.
Predicting Global Trends in COVID-19 Cases Via Online Symptom Checkers Self-Assessments	Zobel,  Marc,  Martin, et al	SSRN- Lancet prepublication	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	This study assessed the use of the online symptom checker Symptoma during the COVID-19 pandemic and correlated use with spatial and temporal data. The study observed a high correlation between the number of users assessed to have a high risk of a COVID-19 infection and the official infection numbers. It also showed that the symptom checker is predictive (median +5 days) of the official infection numbers.
Can Physical exercise be an effective adjuvant before the potential COVID-19 vaccine? Insights from serological responses and severity of re-infected cases	AbdelMassih,  Antoine,  Menshawey, et al	Research Square prepub	Review Literature| Revue de littérature
The dying patient: taboo, controversy and missing terms of reference for designers-an architecturaperspective	Bellamy,  A,  Clark, et al	Med Humanit	Review Literature| Revue de littérature
The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19	Bellis,  A,  Mauro, et al	Int J Mol Sci	Review Literature| Revue de littérature
Hemodynamic characteristics of COVID-19 patients with acute respiratory distress syndrome requiring mechanical ventilation. An invasive assessment using right heart catheterization	Caravita,  S,  Baratto, et al	Eur J Heart Fail	Review Literature| Revue de littérature
PMC7438995; Epigenetic susceptibility to severe respiratory viral infections and its therapeutic implications: a narrative review	Crimi,  E,  Benincasa, et al	Br J Anaesth	Review Literature| Revue de littérature
Mechanical Ventilation Supply and Options for the COVID-19 Pandemic: Leveraging All Available Resources for a Limited Resource in a Crisis	Dar,  M,  Swamy, et al	Ann Am Thorac Soc	Review Literature| Revue de littérature
Adherence to Immunization: Rebuttal of Vaccine Hesitancy	Etzioni-Friedman,  T,  Etzioni, et al	Acta Haematol	Review Literature| Revue de littérature
Recent Clinical and Preclinical Studies of Hydroxychloroquine on RNA Viruses and Chronic Diseases: A Systematic Review	Faraone,  I,  Labanca, et al	Molecules	Review Literature| Revue de littérature	SR: systematic search of Scopus and PubMed databases was performed. By contrast, HCQ arises as a first-line treatment in managing autoimmune diseases such as rheumatoid arthritis, lupus erythematosus, and Sjögren syndrome. It also improves glucose and lipid homeostasis and reveals significant antibacterial activity.
Applications of CMOS Devices for the Diagnosis and Control of Infectious Diseases	Forouhi,  S,  Ghafar-Zadeh, et al	Micromachines (Basel)	Review Literature| Revue de littérature
PMC7452848; The COVID-19 pandemic in Greece, Iceland, New Zealand, and Singapore: Health policies and lessons learned	Fouda,  A,  Mahmoudi, et al	Health Policy Technol	Review Literature| Revue de littérature
Impact of the COVID-19 Pandemic on the Education of Plastic Surgery Trainees in the United States	Hamidian Jahromi,  A,  Arnautovic, et al	JMIR Med Educ	Review Literature| Revue de littérature
An Immediate and Long-Term Complication of COVID-19 May Be Type 2 Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and Exploration of Possible Mechanisms	Hayden,  MR	Cells	Review Literature| Revue de littérature
Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review	Izcovich,  A,  Ragusa, et al	PLoS One	Review Literature| Revue de littérature	SR:  conducted highly sensitive searches in PubMed/MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL) and Embase. The searches covered the period from the inception date of each database until April 28, 2020.  Identified prognostic factors can help clinicians and policy makers in tailoring management strategies for patients with COVID-19 infectious disease while researchers can utilise our findings to develop multivariable prognostic models that could eventually facilitate decision-making and improve patient important outcomes.
What is the Efficacy and Safety of Rapid Exercise Tests for Exertional Desaturation in Covid-19: A Rapid Systematic Review	Kalin,  Asli,  Javid, et al	Research Square prepub	Review Literature| Revue de littérature	SR: AMED, CINAHL, EMBASE MEDLINE, Cochrane and PubMed using LitCovid, Scholar and Google databases were searched to September 2020. We found no studies on the 40-step walk test (a less demanding test that is widely used in clinical practice to assess Covid-19 patients). Discussion Exertional desaturation tests have not yet been validated in patients with (or suspected of having) Covid-19.
The Potential of Glycyrrhizinate in the Management of COVID-19: A Systematic Review of the Efficacy and Safety of Glycyrrhizin Preparations in the Treatment of SARS and MERS	Li,  H,  Hu, et al	Am J Chin Med	Review Literature| Revue de littérature	SR:  Electronic databases were systematically searched from inception to February 2020. Based on the available evidence regarding glycyrrhizin preparations for treating SARS and MERS, we infer that compound glycyrrhizin could be an optional therapeutic strategy for SARS-CoV-2 infections, especially those complicated with liver damage. Further research using well-designed randomized clinical trials (RCTs) is warranted to determine the dosage and duration of use of compound glycyrrhizin and to monitor its specific adverse effects.
Middle Ear Viral Load Considerations in the COVID-19 Era: A Systematic Review	Liaw,  J,  Saadi, et al	Otol Neurotol	Review Literature| Revue de littérature	SR: DATA SOURCES: PubMed, MEDLINE, and Cochrane databases.  The medical literature has consistently demonstrated the presence of nucleic acids of respiratory viruses involving the middle ear, including SARS-CoV2 in a recent postmortem study. Although no in vivo studies have been conducted, due to the likely risk of transmission, middle ear and mastoid procedures, particularly involving the use of a drill should be deferred, if possible, during the pandemic and enhanced personal protective equipment (PPE) used if surgery is necessary.
Vitamin D3 as Potential Treatment Adjuncts for COVID-19	Malaguarnera,  L	Nutrients	Review Literature| Revue de littérature
Pharmacy Internal Controls: A Call for Greater Vigilance during the COVID-19 Pandemic	Mason,  AN	Pharmacy (Basel)	Review Literature| Revue de littérature
Transmission Modes of COVID-19: A Systematic Review	Mehraeen,  E,  Salehi, et al	Infect Disord Drug Targets	Review Literature| Revue de littérature	SR: We searched selected keywords in six important databases to discover related sources on the main objective of the study. Droplet and contact with contaminated surfaces were the most frequent transmission modes of COVID-19. Fecal excretion, environmental contamination, and fluid pollution might contribute to a viral transmission. The possibility of fecal transmission of COVID-19 has implications, especially in areas with poor sanitation and the environmental pollution can be caused by patients with SARS-CoV-2 through respiratory droplets and feces, subsequently, the human environment will change to a potential medium of virus transmission.
Impact of cardiovascular and metabolic diseases on the severity of COVID-19: a systematic review and meta-analysis	Meng,  M,  Zhao, et al	Aging (Albany NY)	Review Literature| Revue de littérature	SR-MA: performed a comprehensive, systematic literature search for studies published between December 2019 and July 5, 2020 in five databases. Our findings suggest patients with CHD, hypertension and diabetes are at greater risk for developing severe COVID-19 than those without these conditions.
Prone ventilation as treatment of acute respiratory distress syndrome related to COVID-19	Petrone,  P,  Brathwaite, et al	Eur J Trauma Emerg Surg	Review Literature| Revue de littérature
Potential Detrimental Role of Soluble ACE2 in Severe COVID-19 Comorbid Patients	Rahman,  Mohammad Mahmudur,  Hasan, et al	SSRN- Lancet prepublication	Review Literature| Revue de littérature
Implications of SARS-CoV-2-Associated Myocarditis in the Medical Evaluation of Athletes	Raukar,  NP,  Cooper, et al	Sports Health	Review Literature| Revue de littérature
PMC7531283; Zero-shot learning and its applications from autonomous vehicles to COVID-19 diagnosis: A review	Rezaei,  M,  Shahidi, et al	Intell Based Med	Review Literature| Revue de littérature
Endothelial pulsatile shear stress is a backstop for COVID-19	Sackner,  MA,  Adams, et al	Emerg Top Life Sci	Review Literature| Revue de littérature
Personal Protective Equipment during COVID-19 Pandemic: A Narrative Review on Technical Aspects	Saran,  S,  Gurjar, et al	Expert Rev Med Devices	Review Literature| Revue de littérature
The genetic structure of SARS-CoV-2 does not rule out a laboratory origin: SARS-COV-2 chimeric structure and furin cleavage site might be the result of genetic manipulation	Segreto,  R,  Deigin, et al	Bioessays	Review Literature| Revue de littérature
Eliciting B cell immunity against infectious diseases using nanovaccines	Singh,  A	Nat Nanotechnol	Review Literature| Revue de littérature
Development and Applications of Viral Vectored Vaccines to Combat Zoonotic and Emerging Public Health Threats	Vrba,  SM,  Kirk, et al	Vaccines (Basel)	Review Literature| Revue de littérature
PMC7664603; Lactoferrin for the treatment of COVID-19 (Review)	Wang,  Y,  Wang, et al	Exp Ther Med	Review Literature| Revue de littérature
The effects of hypertension as an existing comorbidity on mortality rate in patients with COVID-19: a systematic review and meta-analysis	Whiteman,  Elena	medRxiv	Review Literature| Revue de littérature	SR-MA: literature search in several databases was performed to identify studies that comment on hypertension as an existing comorbidity, and its effect on mortality in hospitalized patients with confirmed COVID- 19 infection.
Venous thromboembolic events in patients with COVID-19: A systematic review and meta-analysis	Wu,  T,  Zuo, et al	Age Ageing	Review Literature| Revue de littérature	SR-MA: VTE is a common complication in severe COVID-19 patients and thromboembolic events are also associated with adverse outcomes.
The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure	Xie,  ZJ,  Novograd, et al	Antioxidants (Basel)	Review Literature| Revue de littérature
Obesity aggravates COVID-19: an updated systematic review and meta-analysis	Yang,  J,  Tian, et al	J Med Virol	Review Literature| Revue de littérature	SR-MA: ubMed, EMBASE, and Web of Science were searched to find articles published between December 1, 2019, and July 27, 2020. Obesity could promote the occurrence of the whole course of COVID-19. A higher degree of obesity may predict a higher risk.
A Systematic Narrative Review of Comprehensive Preparedness Strategies of Healthcare Resources for a Large Resurgence of COVID-19 Nationally, with Local or Regional Epidemics: Present Era and Beyond	Yoon,  YK,  Lee, et al	J Korean Med Sci	Review Literature| Revue de littérature
Suicide in the Time of COVID-19: Review and Recommendations	Zalsman,  G,  Stanley, et al	Arch Suicide Res	Review Literature| Revue de littérature
Characteristics of pediatric multi-system inflammatory syndrome (PMIS) associated with COVID-19: a meta-analysis and insights into pathogenesis	Zou,  H,  Lu, et al	Int J Infect Dis	Review Literature| Revue de littérature	SR-MA:  systematic review on PubMed and Embase from the time of inception to June 24th 2020 in order to find relevant cases.Our study documented three common types of PMIS clinical presentation: persistent fever and gastrointestinal symptoms, shocked with heart dysfunction and Kawasaki disease-like syndrome. PMIS patients proved with a marked inflammatory state were possibly associated with SARS-CoV-2 infection.
Alcohol misuse may increase the severity of COVID-19 infections	Abbasi-Oshaghi,  E,  Mirzaei, et al	Disaster Med Public Health Prep	Commentary/Editorial| Commentaire/Éditorial
Establishment of COVID-19 testing laboratory in resource-limited settings: challenges and prospects reported from Ethiopia	Abera,  A,  Belay, et al	Glob Health Action	Commentary/Editorial| Commentaire/Éditorial
A bibliometric methodology to unveil territorial inequities in the scientific wealth to combat COVID-19	Abramo,  Giovanni,  D'Angelo, et al	arXiv	Commentary/Editorial| Commentaire/Éditorial
PMC7661834; Infections of the lung: a predictive, preventive and personalized perspective through the lens of evolution, the emergence of SARS-CoV-2 and its pathogenesis	Ahluwalia,  P,  Ahluwalia, et al	EPMA J	Commentary/Editorial| Commentaire/Éditorial
Availability of COVID-19 Vaccine: Regulation and Indonesian Policy to Deal With It	Al Mukarramah,  Nurul Habaib,  Maskun, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Burnout And Depression Among Psychiatry Residents During Covid-19 Pandemic	Alkhamees,  AbdulmajeedA,  Assiri, et al	Research Square prepub	Commentary/Editorial| Commentaire/Éditorial
PMC7425544; Changes in healthcare managing COVID and non-COVID-19 patients during the pandemic: striking the balance	Al-Tawfiq,  J,  Al-Yami, et al	Diagn Microbiol Infect Dis	Commentary/Editorial| Commentaire/Éditorial
COVID-19 pandemic in Japan	Amengual,  O,  Atsumi, et al	Rheumatol Int	Commentary/Editorial| Commentaire/Éditorial
Prioritizing critical-care resources in response to COVID-19: lessons from the development of Thailand's Triage protocol	Archer,  RA,  Marshall, et al	Int J Technol Assess Health Care	Commentary/Editorial| Commentaire/Éditorial
[Statement of the German Society for Rheumatology (DGRh) on the use of video consultations in rheumatology]	Aries,  P,  Welcker, et al	Z Rheumatol	Commentary/Editorial| Commentaire/Éditorial
Angiotensin-converting enzyme inhibitors (ACEIs) and Angiotensin-receptor blockers (ARBs) benefits outweigh the risks in COVID-19 hypertensive patients	Ateya,  AM,  Sabri, et al	J Med Virol	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and Arboviral Diseases: Another Challenge for Pakistan's Delipidated Healthcare System	Awan,  UA,  Zahoor, et al	J Med Virol	Commentary/Editorial| Commentaire/Éditorial
Is Spain prepared to provide psychological support during the COVID-19 crisis?	Barbosa-Torres,  C	Atencion Primaria	Commentary/Editorial| Commentaire/Éditorial
Metabolic Syndrome and COVID-19: Endocrine-Immune Vascular Interactions Shape the Clinical Course	Barthel,  A,  Mohanraj, et al	Endocrinology	Commentary/Editorial| Commentaire/Éditorial
Expecting the unexpected with COVID-19 vaccines	Bar-Zeev,  Naor,  Kochhar, et al	The Lancet Infectious Diseases	Commentary/Editorial| Commentaire/Éditorial
Two BSHS online alternatives to conventional conferences	Boon,  T,  Sleigh, et al	Br J Hist Sci	Commentary/Editorial| Commentaire/Éditorial
The role of D-dimer in relation to the clinical course of patients with COVID-19	Bosevski,  M,  Krstevski, et al	Acta Biochim Biophys Sin (Shanghai)	Commentary/Editorial| Commentaire/Éditorial
[The pandemic caused by SARS-CoV-2: more than a serious health crisis, a change of time and lessons to be learned urgently]	Bréchot,  C	Med Sci (Paris)	Commentary/Editorial| Commentaire/Éditorial
COVID-19: Understanding Testing	Cadet,  MJ	Workplace Health Saf	Commentary/Editorial| Commentaire/Éditorial
Reduce the spread of COVID-19 within the dental practice: the era of single use	Ceraulo,  S,  Lauritano, et al	Minerva Stomatol	Commentary/Editorial| Commentaire/Éditorial
Canadian College of Medical Geneticists (CCMG) points to consider: resuming genetic services in a pandemic-a summary	Chad,  L,  Dawson, et al	J Med Genet	Commentary/Editorial| Commentaire/Éditorial
The SARS-CoV-2 receptor, Angiotensin converting enzyme 2 (ACE2) is required for human endometrial stromal cell decidualization	Chadchan,  SB,  Popli, et al	Biol Reprod	Commentary/Editorial| Commentaire/Éditorial
Risk attitudes and human mobility during the COVID-19 pandemic	Chan,  HF,  Skali, et al	Sci Rep	Commentary/Editorial| Commentaire/Éditorial
Conspiracy and debunking narratives about COVID-19 origination on Chinese social media: How it started and who is to blame	Chen,  Kaiping,  Chen, et al	arXiv	Commentary/Editorial| Commentaire/Éditorial
Corrigendum to 'The many faces and fangs of COVID-19: an editorial by Sudhansu Chokroverty' [Sleep Med 72 (2020) 164-166]	Chokroverty,  S	Sleep Med	Commentary/Editorial| Commentaire/Éditorial
The effects of the first and second wave of COVID-19 pandemic on public health	Coccia,  Mario	Research Square prepub	Commentary/Editorial| Commentaire/Éditorial
PMC7661802; Measuring employment during COVID-19: challenges and opportunities	Cohen,  GD	Bus Econ	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and acute pancreatitis: examining the causality	de-Madaria,  E,  Capurso, et al	Nat Rev Gastroenterol Hepatol	Commentary/Editorial| Commentaire/Éditorial
Beyond the clot: perfusion imaging of the pulmonary vasculature after COVID-19	Dhawan,  RanjuT,  Gopalan, et al	The Lancet Respiratory Medicine	Commentary/Editorial| Commentaire/Éditorial
Addressing budget reduction and reallocation on health-related resources during COVID-19 pandemic in malaria-endemic countries	Diptyanusa,  A,  Zablon, et al	Malar J	Commentary/Editorial| Commentaire/Éditorial
A team-based approach in primary care can alleviate the burden created by the COVID-19 surgical backlog for people with hip and knee osteoarthritis	Ezzat,  AM,  McCracken, et al	CMAJ	Commentary/Editorial| Commentaire/Éditorial
Choosing wisely during the COVID-19 pandemic: optimising outpatient cancer care while conserving resources with a new algorithm to report automated ANC results	Fenelus,  M,  Graham, et al	J Clin Pathol	Commentary/Editorial| Commentaire/Éditorial
Principes de soins cliniques aux patients atteints de la COVID-19 dans les unités médicales	Frost,  DW,  Shah, et al	CMAJ	Commentary/Editorial| Commentaire/Éditorial
Mass testing for covid-19 in the UK	Gill,  M,  Gray, et al	BMJ	Commentary/Editorial| Commentaire/Éditorial
Cutaneous manifestations of COVID-19 in skin of color: a firsthand perspective of three cases in a tertiary care center in India	Goyal,  S,  Prabhu, et al	Postgrad Med	Commentary/Editorial| Commentaire/Éditorial
PMC7661819; COVID-19's impact on the U.S. labor market as of September 2020	Groshen,  EL	Bus Econ	Commentary/Editorial| Commentaire/Éditorial
COVID-19 Rash	Hartmann,  M,  Salbach, et al	Deutsches Arzteblatt international	Commentary/Editorial| Commentaire/Éditorial
An approach of fatty acids and resveratrol in the prevention of COVID-19 severity	Hoang,  T	Phytother Res	Commentary/Editorial| Commentaire/Éditorial
Covid-19 communication-a matter of life and death?	Hodes,  S	BMJ	Commentary/Editorial| Commentaire/Éditorial
GSK-LSD1, an LSD1 inhibitor, quashes SARS-CoV-2-triggered cytokine release syndrome in-vitro	Hong,  KS,  Ahn, et al	Signal Transduct Target Ther	Commentary/Editorial| Commentaire/Éditorial
The impact of tocilizumab on the mortality of patients with COVID-19	Huang,  YT,  Chao, et al	Clin Infect Dis	Commentary/Editorial| Commentaire/Éditorial
Collaboration Between Public Health and Marketing Experts as a Response to COVID-19	Hughes,  MC,  Tang, et al	Popul Health Manag	Commentary/Editorial| Commentaire/Éditorial
Protocol for a Mixed-Method Investigation of the Impact of the COVID-19 Pandemic and Gambling Practices, Experiences and Marketing in the UK: The "Betting and Gaming COVID-19 Impact Study"	Hunt,  K,  Critchlow, et al	Int J Environ Res Public Health	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and inhibitors of the renin-angiotensin-aldosterone system	Hussain,  M,  Jabeen, et al	Expert Rev Anti Infect Ther	Commentary/Editorial| Commentaire/Éditorial
The role of manufacturers in the implementation of global traceability standards in the supply chain to combat vaccine counterfeiting and enhance safety monitoring	Jarrett,  S,  Wilmansyah, et al	Vaccine	Commentary/Editorial| Commentaire/Éditorial
Manual Fever Check Is More Sensitive than Infrared Thermoscanning Camera for Fever Screening in a Hospital Setting during the COVID-19 Pandemic	Jung,  J,  Kim, et al	J Korean Med Sci	Commentary/Editorial| Commentaire/Éditorial
Pharmacological inhibition of MMP3 as a potential therapeutic option for COVID-19 associated acute respiratory distress syndrome	Kadry,  R,  Newsome, et al	Infect Disord Drug Targets	Commentary/Editorial| Commentaire/Éditorial
Frailty Assessment in Clinical Practice: Opportunity in the Midst of a Pandemic	Keevil,  VL,  Osuafor, et al	Geriatrics (Basel)	Commentary/Editorial| Commentaire/Éditorial
Presenteeism during the COVID-19 pandemic: risks and solutions	Kinman,  G,  Grant, et al	Occup Med (Lond)	Commentary/Editorial| Commentaire/Éditorial
Navigating Through a COVID-19 World: Avoiding Obstacles	Klatt,  BN,  Anson, et al	J Neurol Phys Ther	Commentary/Editorial| Commentaire/Éditorial
Use of DPP-4 inhibitors in patients with COVID-19	Kow,  CS,  Hasan, et al	Acta Diabetol	Commentary/Editorial| Commentaire/Éditorial
Correction to: Hospital-based headache care during the Covid-19 pandemic in Denmark and Norway	Kristoffersen,  ES,  Faiz, et al	J Headache Pain	Commentary/Editorial| Commentaire/Éditorial
PMC7661945; The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19	Kritis,  P,  Karampela, et al	Metabol Open	Commentary/Editorial| Commentaire/Éditorial
Partnership to Make 120 Million COVID-19 Rapid Tests Available	Kuehn,  BM	JAMA	Commentary/Editorial| Commentaire/Éditorial
Identifying pregnant women at risk of developing COVID-19 related mental health problems - a call for enhanced psychoeducation and social support	Lambregtse-van den Berg,  M,  Quinlivan, et al	J Psychosom Obstet Gynaecol	Commentary/Editorial| Commentaire/Éditorial
Triterpenoid-Mediated Inhibition of Virus-Host Interaction: Is Now the Time for Discovering Viral Entry/Release Inhibitors from Nature?	Li,  H,  Sun, et al	J Med Chem	Commentary/Editorial| Commentaire/Éditorial
PMC7661944; Response to "Letter to the Editor: Coronavirus disease 2019 (COVID-19) markedly increased mortality in patients with hip fracture: A systematic review and meta-analysis"	Lim,  M	J Clin Orthop Trauma	Commentary/Editorial| Commentaire/Éditorial
The Effects of Agency Assignment and Reference Point on Responses to COVID-19 Messages	Ma,  H,  Miller, et al	Health Commun	Commentary/Editorial| Commentaire/Éditorial
Falling through the cracks: the impact of COVID-19 on postnatal care in primary care	MacGregor,  R,  Hillman, et al	Br J Gen Pract	Commentary/Editorial| Commentaire/Éditorial
Genetic insight into COVID-19 related liver injury: a note on MBOAT7	Machill,  A,  Bals, et al	Liver Int	Commentary/Editorial| Commentaire/Éditorial
Educating Anesthesiologists During the COVID-19 Pandemic and Beyond	Martinelli,  SM,  Chen, et al	Anesth Analg	Commentary/Editorial| Commentaire/Éditorial
Ambulance documentation of stroke symptoms during the UK COVID-19 'Stay at Home' message	McClelland,  G,  Wilson, et al	Emerg Med J	Commentary/Editorial| Commentaire/Éditorial
PMC7661943; Fibromyalgia and Chronic Fatigue Syndrome in the Age of COVID-19	Mohabbat,  AB,  Mohabbat, et al	Mayo Clin Proc Innov Qual Outcomes	Commentary/Editorial| Commentaire/Éditorial
PMC7661827; Central bank responses to COVID-19	Mosser,  PC	Bus Econ	Commentary/Editorial| Commentaire/Éditorial
Introduction to the Special Forum on "Public Health Communication in an Age of COVID-19"	Nan,  X,  Thompson, et al	Health Commun	Commentary/Editorial| Commentaire/Éditorial
SeekNet: Improved Human Instance Segmentation via Reinforcement Learning Based Optimized Robot Relocation	Narayanan,  Venkatraman,  Manoghar, et al	arXiv	Commentary/Editorial| Commentaire/Éditorial
COVID-19 cytokine storm: what is in a name?	Nigrovic,  PA	Ann Rheum Dis	Commentary/Editorial| Commentaire/Éditorial
Crisis of emerging antibiotic resistances mirroring that of the COVID-19 in the age of globalisation	Nordmann,  P,  Poirel, et al	Swiss Med Wkly	Commentary/Editorial| Commentaire/Éditorial
Communicating Uncertainties during the COVID-19 Outbreak	Paek,  HJ,  Hove, et al	Health Commun	Commentary/Editorial| Commentaire/Éditorial
Therapeutic potential of inhalable medications to combat coronavirus disease-2019	Parvathaneni,  V,  Kulkarni, et al	Ther Deliv	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and Crimean-Congo Hemorrhagic Fever: Similarities and Differences	Pazarlı,  AC,  Parlak, et al	Heart and Lung	Commentary/Editorial| Commentaire/Éditorial
Iran Coping Experiences with COVID-19: Strategies and Recommendations	Peyravi,  M,  Soltani, et al	Disaster Med Public Health Prep	Commentary/Editorial| Commentaire/Éditorial
Focus on the Potential Role of Lung Ultrasound in COVID-19 Pandemic: What More to Do?	Ragnoli,  B,  Malerba, et al	Int J Environ Res Public Health	Commentary/Editorial| Commentaire/Éditorial
Use of low molecular weight heparin (LMWH) in primary care is plausible in patients with COVID-19	Reinders,  C	Pharmaceutisch weekblad	Commentary/Editorial| Commentaire/Éditorial
Social disparity in magnifying glass: the inequality among the vulnerable people during COVID-19 pandemic	Ribeiro Ribeiro,  AL,  Alves Sousa, et al	Int J Clin Pract	Commentary/Editorial| Commentaire/Éditorial
Response to: How important is the assessment of soluble ACE-2 in COVID-19?	Rieder,  M,  Bode, et al	Am J Hypertens	Commentary/Editorial| Commentaire/Éditorial
The Role of Medical Students During the COVID-19 Pandemic	Riva,  MA,  Paladino, et al	Ann Intern Med	Commentary/Editorial| Commentaire/Éditorial
Innovation in a crisis: rethinking conferences and scholarship in a pandemic and climate emergency	Robinson,  S,  Baumhammer, et al	Br J Hist Sci	Commentary/Editorial| Commentaire/Éditorial
La COVID-19 et les priorités de la recherche sur le vieillissement	Rylett,  RJ,  Alary, et al	Canadian Journal on Aging	Commentary/Editorial| Commentaire/Éditorial
Implications of renal ACE2 expression in the age of COVID-19	Salah,  HM,  Arthur, et al	Eur Heart J	Commentary/Editorial| Commentaire/Éditorial
PMC7450947; Rapid response to crisis: Health system lessons from the active period of COVID-19	Salvador-Carulla,  L,  Rosenberg, et al	Health Policy Technol	Commentary/Editorial| Commentaire/Éditorial
Possible association between IgA vasculitis and COVID-19	Sandhu,  S,  Chand, et al	Dermatol Ther	Commentary/Editorial| Commentaire/Éditorial
Placental Pathology of COVID-19 with and without Fetal and Neonatal Infection: Trophoblast Necrosis and Chronic Histiocytic Intervillositis as Risk Factors for Transplacental Transmission of SARS-CoV-2	Schwartz,  DA,  Morotti, et al	Viruses	Commentary/Editorial| Commentaire/Éditorial
PMC7528449; Correction to: Review of the efforts of the Japanese Society of Echocardiography for coronavirus disease 2019 (COVID-19) during the initial outbreak in Japan	Seo,  Y,  Daimon, et al	J Echocardiogr	Commentary/Editorial| Commentaire/Éditorial
The other side of COVID-19 pandemic: Effects on male fertility	Seymen,  CM	J Med Virol	Commentary/Editorial| Commentaire/Éditorial
Change point detection for COVID-19 excess deaths in Belgium	Shang,  Han Lin,  Xu, et al	arXiv	Commentary/Editorial| Commentaire/Éditorial
Why Is Headache Protective for COVID-19? Migraine as An Evolutionary Adaptation	Shapiro,  RobertE,  Pozo-Rosich, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Covid-19: North Dakota and Belgium have let infected health staff work on wards	Silberner,  J	BMJ	Commentary/Editorial| Commentaire/Éditorial
Should we be re-starting elective surgery?	Simoes,  J,  Bhangu, et al	Anaesthesia	Commentary/Editorial| Commentaire/Éditorial
Characteristics associated with changes in food security status among college students during the COVID-19 pandemic	Soldavini,  J,  Andrew, et al	Transl Behav Med	Commentary/Editorial| Commentaire/Éditorial
Reply to letter to the editor regarding "Use of DPP-4 inhibitors in patients with COVID-19"	Solerte,  SB,  D'Addio, et al	Acta Diabetol	Commentary/Editorial| Commentaire/Éditorial
Targeting the renin-angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges	Sriram,  K,  Loomba, et al	Proc Natl Acad Sci U S A	Commentary/Editorial| Commentaire/Éditorial
Legislative preparedness for the control of pandemics - using Taiwan as an example	Su,  YC	Med Leg J	Commentary/Editorial| Commentaire/Éditorial
Newly identified limitations of diagnostic tools for COVID-19 and consequences	Syal,  K	J Med Virol	Commentary/Editorial| Commentaire/Éditorial
Évaluation du risque de contamination par le coronavirus après chirurgie robotique durant la pandémie COVID-19	Tabourin,  T,  Sarfati, et al	Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie	Commentary/Editorial| Commentaire/Éditorial
Point-of-care testing for respiratory infections during and after COVID-19	Thornton,  HV,  Khalid, et al	Br J Gen Pract	Commentary/Editorial| Commentaire/Éditorial
PMC7451008; COVID-19 pandemic in Finland - Preliminary analysis on health system response and economic consequences	Tiirinki,  H,  Tynkkynen, et al	Health Policy Technol	Commentary/Editorial| Commentaire/Éditorial
The misleading "pooled effect estimate" of crude data from observational studies at critical risk of bias: The case of Tocilizumab in COVID-19	Tleyjeh,  IM	Clin Infect Dis	Commentary/Editorial| Commentaire/Éditorial
Covid-19: Third candidate vaccine will be tested in UK	Torjesen,  I	BMJ	Commentary/Editorial| Commentaire/Éditorial
Choice and management of vascular access in the context of COVID-19 outbreak in Italy: Recommendations from clinical practice	Vailati,  D,  Montrucchio, et al	J Vasc Access	Commentary/Editorial| Commentaire/Éditorial
Mitigating the Impact of COVID-19 on Funded Clinical Research: Crucial Next Steps	Walker,  RJ,  Jackson, et al	J Gen Intern Med	Commentary/Editorial| Commentaire/Éditorial
Does tocilizumab have a magical therapeutic effect on COVID-19 patients without obvious adverse reactions?	Wang,  Y,  Mao, et al	Proc Natl Acad Sci U S A	Commentary/Editorial| Commentaire/Éditorial
Youth sports in the wake of COVID-19: a call for change	Watson,  A,  Koontz, et al	Br J Sports Med	Commentary/Editorial| Commentaire/Éditorial
Covid-19 test and trace: localised approach urgently needed	Watson,  MC,  Coufopoulos, et al	BMJ	Commentary/Editorial| Commentaire/Éditorial
PMC7661925; COVID-19 and Elder Health Inequity in Dialysis	Wong,  LP	Kidney Med	Commentary/Editorial| Commentaire/Éditorial
How should we use convalescent plasma therapies for COVID-19?	Wood,  EM,  Estcourt, et al	Blood	Commentary/Editorial| Commentaire/Éditorial
Dose Selection in a Pandemic: A Framework Informed by the FDA Animal Rule	Wu,  K,  Bergman, et al	Clin Transl Sci	Commentary/Editorial| Commentaire/Éditorial
Correction to: A New Normal or Business-as-Usual? Lessons for COVID-19 from Financial Crises in East and Southeast Asia (The European Journal of Development Research, (2020), 10.1057/s41287-020-00327-3)	Yap,  OF	European Journal of Development Research	Commentary/Editorial| Commentaire/Éditorial
PMC7661909; Natural history of COVID-19: Back to the Basics	Zayet,  S,  Gendrin, et al	New Microbes New Infect	Commentary/Editorial| Commentaire/Éditorial
Adapting to the "New Normal" in Orthopaedic Trauma During COVID-19	Zhang,  J,  Yam, et al	Annals of the Academy of Medicine, Singapore	Commentary/Editorial| Commentaire/Éditorial
Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial	Zhang,  Yanjun,  Zeng, et al	The Lancet Infectious Diseases	Commentary/Editorial| Commentaire/Éditorial
Corrigendum to "COV is a readily available quantitative indicator of metabolic heterogeneity for predicting survival of patients with early and locally advanced NSCLC manifesting as central lung cancer" [Eur. J. Radiol. 132 (2020) 109338]	Zhao,  P,  Pan, et al	Eur J Radiol	Commentary/Editorial| Commentaire/Éditorial
Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin	Zhou,  P,  Yang, et al	Nature	Commentary/Editorial| Commentaire/Éditorial
Corrigendum: Interferon-α2b Treatment for COVID-19 (Frontiers in Immunology, (2020), 11, (1061), 10.3389/fimmu.2020.01061)	Zhou,  Q,  Chen, et al	Frontiers in Immunology	Commentary/Editorial| Commentaire/Éditorial
The Effect of Different Ventilation Modes on the Outcomes of Patients Infected with Coronavirus Disease 2019 (COVID-19): a Protocol of Systematic Review and Network Meta-Analysis	Zhu,  Yihao,  Wang, et al	Research Square prepub	Commentary/Editorial| Commentaire/Éditorial
Be aware: COVID-19 the new stroke mimicker	Zuurbier,  SM,  Verschelde, et al	Acta Neurol Belg	Commentary/Editorial| Commentaire/Éditorial
Erratum: Vol. 69, No. 43: COVID-19-Associated Hospitalizations Among Health Care Personnel - COVID-NET, 13 States, March 1-May 31, 2020		MMWR Morb Mortal Wkly Rep	Commentary/Editorial| Commentaire/Éditorial
Erratum to New York Transplant Teams Versus COVID-19		Prog Transplant	Commentary/Editorial| Commentaire/Éditorial
Correction to: From containment to harm reduction from SARS-CoV-2: a fabric mask for enhanced effectiveness, comfort, and compliance(The Journal of the Textile Institute, (2020), 10.1080/00405000.2020.1805971)		Journal of the Textile Institute	Commentary/Editorial| Commentaire/Éditorial
Erratum: Convalescent plasma in the management of moderate covid-19 in adults in India: Open label phase II multicentre randomised controlled trial (PLACID Trial) (The BMJ (2020) 371 (m3939) DOI: 10.1136/bmj.m3939)		The BMJ	Commentary/Editorial| Commentaire/Éditorial

Appendix: Process and definitions. 

A daily search for new publications is conducted in PubMed, Scopus, BioRxiv and MedRxiv, SSRN, Research Square, arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2 OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database.  The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google.  Publishers include Lancet, Elsevier, The New England Journal of Medicine, BMJ, Wiley, Springer Nature, ChinaCDCweekly. Additionally the database is cross-referenced with other literature scans and activities by collaborators.  Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa Waddell for additional information: Lisa.Waddell@canada.ca.  References are compiled in a reworks database that has citations since the beginning of the outbreak.  All references can be accessed at this link and by the categories listed below.  The daily scan has also been compiled in an excel sheet and copies can be provided upon request or accessed here.

Category Definitions:

Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely to influence future results.

Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro, attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*

Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.

Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.* 

Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.

Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers. 

Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data.  Surveillance data will likely be number of cases suspected/confirmed, number of deaths, number recovered. *

Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses

Diagnostics / Pathogen detection:  All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.

Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.

Vaccine Research:  Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.

Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.

Public Health interventions*: Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).

Public Health response: Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.

Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC

Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to:  set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.

Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.

Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)

Animal Model: An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the added risk of harming an actual human.

Zoonotic: all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.

Review Literature:  All articles that summarize the published literature can be tagged as a review.  This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*

Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary category.

News articles that have not scientific information.

*Lists are not exhaustive

Annexe: Processus et définitions. 

Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus, BioRxiv and MedRxiv, SSRN, Research Square, arXiv pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV).  La saisie renvoie à des annonces de publication sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google.  Parmi les éditeurs figurent Lancet, Elsevier, The New England Journal of Medicine, BMJ, Wiley, Springer Nature, ChinaCDCweekly.  En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.  Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au : Lisa.Waddell@canada.ca.  Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie.  Toutes les références sont accessibles à partir de ce lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées ici.

Définitions des catégories :

Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats. Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.

Épidémiologie : Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque, le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.

Transmission : Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.

Données cliniques des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.* 

Séquelles à long terme: Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.

Santé mentale: Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.

Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.  Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *

Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.

Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes, etc.

Thérapeutique : Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.

Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.

Priorités de santé publique : Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.

Interventions de santé publique* : Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).

Réponse de la santé publique : Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées à la pandémie.

Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) : Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.

Réponse des soins de santé : Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment :  mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux / stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.

Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)

Modèle animal: Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.

Zoonotic: all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.

Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19

Revue de la documentation :  Tous les articles qui résument les documents publiés peuvent être marqués comme une revue.  Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.

Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.

journaux Articles de presse qui n'ont pas d'informations scientifiques.

* Les listes ne sont pas exhaustives