Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19,
2020-11-16
Good afternoon,
There are 502 citations in today’s scan. 313 were considered primary research or review literature.
Highlights today include:
CANADA
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Field et al., performed a randomized, double-blind, multicenter, placebo-controlled study evaluating treatment with a single 180 µg subcutaneous injection
of peginterferon-lambda or placebo in outpatients with COVID-19.
Peginterferon-lambda accelerated viral decline in outpatients with COVID-19 resulting in a greater proportion with viral clearance by Day 7, particularly in those with high baseline viral load.
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Fisman et al estimate seroprevalence using retention samples stored by Canadian Blood Services in May 2020. Overall the infection fatality
ratio (IFR) was estimated to be 0.80% (0.75-0.85%) consistent with estimates from other jurisdictions. IFR increased exponentially with age from 0.01% in those aged 20-29 years, to 12.71% in those aged 70 and over. They estimated that 5.88 infections occurred
for every case identified, with a higher fraction of cases identified in those aged 70 and older (42.0%) than those aged 20-29 (9.4%).
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Sundaram et al
conducted cross-sectional analyses in Ontario, Canada comparing individual, environmental, and social determinants among individuals who were tested versus not yet tested. Of a total of 14.7 million individuals, 758,691 had been tested, of whom 25,030
(3.3%) tested positive. Residing in areas with highest household density, lowest educational attainment, and highest proportion of recent immigrants were consistently related to increased odds of COVID-19 across analytic designs.
PUBLIC HEALTH INTERVENTION
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Dollard et al.
report on the efficacy of an enhanced entry risk assessment and management (screening) program in the US for air passengers arriving from certain countries with widespread, sustained transmission of SARS-CoV-2. During January 17-September 13, 2020, a
total of 766,044 travelers were screened, 298 (0.04%) of whom met criteria for public health assessment; 35 (0.005%) were tested for SARS-CoV-2, and nine (0.001%) had a positive test result. Passenger entry screening was resource-intensive with low yield of
laboratory-diagnosed COVID-19 cases (one case per 85,000 travelers screened).
TRANSMISSION
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Dai et al
demonstrate that SARS-CoV-2 can survive on fish for more than one week at 4°C, the temperature of refrigerators, cold rooms, or transport carriers for storage of fish before selling in markets. Under such condition, SARS-CoV-2-contaminated fish from
one country can be easily transported to another country within one week and, thus, may serve as a source for international transmission of SARS-CoV-2.
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Mahale et al
investigated a COVID-19 outbreak linked to a wedding reception attended by 55 persons in a rural Maine town. In addition to the community outbreak, secondary and tertiary transmission led
to outbreaks at a long-term care facility 100 miles away and at a correctional facility approximately 200 miles away. Overall, 177 COVID-19 cases were epidemiologically linked to the event, including seven hospitalizations
and seven deaths (four in hospitalized persons).
EPIDEMIOLOGY
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Zhou et al.
aimed to delineate the clinical characteristics associated with long-term viral shedding (>21 days) in a cohort of 609 patients with COVID-19, from two hospitals in Wuhan. When comparing patients with early (≤21 days) and late viral RNA clearance (>21
days), prolonged viral shedding was associated with age <65, female sex, cough, fatigue, sore throat, aspartate aminotransferase, procalcitonin, albumin, D-dimer, lung involvement, reticular shadow and lung consolidation.
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Aran et al
report that immunological cross-reactivity between common cold coronaviruses (CCC) and SARS-CoV-2 might account for the reduced incidence of COVID-19 in children. After adjusting for age, gender and care seeking behavior, we identified that individuals
with diagnoses for common cold symptoms, including acute sinusitis, bronchitis, or pharyngitis in the preceding year had a lower risk of testing positive for SARS-CoV-2
·
Giuseppe et al. We investigated whether Google searches volume for two disease-specific symptoms, taste
and smell, could be associated with disease epidemiology in the United States. The correlation coefficient of summing Google Trends scores for the two symptoms and the number of new weekly SARS-CoV-2 infections two weeks later was 0.82, and was associated
with 0.89 diagnostic accuracy
CLINICAL DATA
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Marchev et al. We present a clinical case of a patient with reactivation of SARS-CoV-2 infection after strenuous exercise in the gym. Reactivation
of the virus was confirmed after detecting SARS-CoV-2 in a nasopharyngeal swab sample using real-time polymerase chain reaction (PCR). The clinical symptoms of the patient - fever and shortness of breath, as well as the presence of IgM antibodies further confirmed
the diagnosis.
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Slaats et al.
present a case report of a 7-day-old boy was admitted to the hospital with fever, lethargy and apnoea. He was found SARS-CoV-2 RNA positive with an exceptionally high viral load in nasopharyngeal swab and stool. The father and two maternity nurses at
home also had detectable SARS-CoV-2 RNA, belonging to the same cluster.
IMMUNOLOGY
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Vetter et al
monitored shedding of viral RNA and infectious virus and characterized the immune response kinetics of the first five patients quarantined in Geneva, Switzerland. High viral loads and infectious virus shedding were observed from the respiratory tract
despite mild symptoms, with isolation of infectious virus and prolonged positivity by reverse transcriptase PCR until days 7 and 19 after symptom onset, respectively. Robust innate responses characterized by increases in activated CD14(+) CD16(+) monocytes
and cytokine responses were observed as early as 2 days after symptom onset.
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Tosif et al
present data that indicate children can mount an immune response to SARS-CoV-2 without virological confirmation of infection, raising the possibility that immunity in children can prevent the establishment of SARS-CoV-2 infection.
CORONAVIROLOGY
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Shen et al
used the atomic structure model of SARS-CoV-2 and human ACE2 to assess the receptor utilization capacity of ACE2s from 10 kinds of animals. Results show that chimpanzees, domestic cats and cattles are more susceptible to infection by SARS-CoV-2.
DIAGNOSTICS
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Coryell at el., sought to adapt and validate an available test specifically for detection of SARS-CoV-2 in human stool. The lower limit of detection (LoD)
of the assay was found to be 3000 viral RNA copies per gram of original stool sample, with 100% detection across 20 replicates assessed at this concentration. Thirty contrived SARS-CoV-2 samples were tested by a second laboratory and were correctly identified
as positive or negative in at least one of two rounds of testing.
·
Bal et al., found that H69 and V70 deletions resulted in a false negative result for the spike target of a commercial RT-PCR assay. From August 3rd to
November 1st, 39/6964 (0.56%) of positive tests performed in Lyon, France, displayed a S negative profile suggesting a limited circulation of the deleted variant.
·
Yamazaki et al.
To diagnose COVID-19 patients in the field, a sensitive point-of-care test using saliva was developed. Using a heat block without centrifuge, the test took 45 minutes. Naked eye judgement with color change dye outperformed the reference standard, with
a diagnostic sensitivity of 82.6% (19/23) and diagnostic specificity of 100% (21/21).
PUBLIC HEALTH RESPONSE
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Davis et al., fielded a national household survey in English and Spanish from June 5-10, 2020. Parents were asked about their likelihood of immunizing
their children and themselves against COVID-19. Overall, 63% of parents were likely to vaccinate their children against COVID-19, and 60% were likely to get a vaccine themselves.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley Otten, Drew
Greydanus, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark, Catherine Card, Ruey Su, Paul McLaren
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics /
Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance,
Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, Immunologie,
économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Comparison of SARS-COV-2 nasal antigen test to nasopharyngeal RT-PCR in mildly symptomatic patients |
Abdulrahman, Abdulkarim, Mustafa, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In this study, we are testing the diagnostic performance of a rapid antigen detection test in mildly symptomatic cases.
(RADT). Methods The study included 4183 male patients who were mildly symptomatic. A nasal sample for the rapid antigen test and a nasopharyngeal sample was taken from each patient. Results The prevalence of COVID 19 in the study population was 17.5% (733/4183).
The calculated sensitivity and specificity were 82.1% and 99.1% respectively. Kappa coefficient of agreement between the rapid antigen test and RT-PCR was 0.859. |
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Akdur, A, Karakaya, et al |
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation |
Healthcare Response | Réponse des soins de santé |
Here, we aimed to evaluate our transplant results, which we safely performed during a 6-month pandemic period. According to our results, when precautions
are taken, transplant does not pose a risk to patients during the pandemic period. We attribute the safety and success shown to our newly developed protocol in response to the COVID-19 pandemic. |
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Akudjedu, TN, Botwe, et al |
Radiography |
Mental Health |
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This study aimed to assess the radiographers’ perspective on the impact of the pandemic on their wellbeing and imaging service delivery in Ghana. Of the
respondents, 75.4% (n = 101) reported to have started experiencing high levels of workplace-related stress after the outbreak. Three-quarters (n = 98, 73.1%) of respondents reported limited access to any form of psychosocial support systems at work during
the study period. Half (n = 67, 50%) of the respondents reported a decline in general workload during the study period while only a minority (n = 18, 13.4%) reported an increase in workload due to COVID-19 cases |
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Inhalable Hydroxychloroquine Powders for Potential Treatment of COVID-19 |
Albariqi, AH, Chang, et al |
J Aerosol Med Pulm Drug Deliv |
Therapeutics| Thérapeutique |
Hydroxychloroquine (HCQ) is one of the repurposed drugs proposed for the treatment of coronavirus disease 2019 (COVID-19). Direct inhaled delivery could
reduce the side effects associated with oral use and ensure a high concentration of the drug in the lungs. In this study, inhalable HCQ powders were prepared and characterized for potential COVID-19 therapy.The jet-milled powder showed a volume median diameter
of 1.7 μm (span 1.5) and retained the same crystalline form as the raw HCQ-sul. A small amount of amorphous materials was present in the jet-milled HCQ-sul, which was convertible to the stable, crystalline state after conditioning at 53%, 58%, and 75% RH.
The recovered fine particle fraction (FPF)recovered and the emitted fine particle fraction (FPFemitted) of the HCQ-sul sample immediately after jet milling and the samples after conditioning at 43%, 53%, and 58% RH were similar at
∼43% and 61%, respectively. In contrast, the sample having conditioned at 75%RH showed lower
corresponding values at 33% and 26% respectively, due to the formation of solid bridges caused by excessive moisture. Inhalable crystalline powders of HCQ-sul were successfully prepared, which can be used for clinical testing as a potential inhaled COVID-19
treatment. |
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Alhasan, A, Audah, et al |
International Journal of Pervasive Computing and Communications |
Healthcare Response | Réponse des soins de santé |
This study aims to examine the doctors’ intentions to use IoT healthcare devices in Iraq during the COVID-19 pandemic. The findings revealed that compatibility
and image of the innovation diffusion theory (IDT) factors, have a significant impact on the perceived ease of use, perceived usefulness and behavioral intention, but trialability has a significant impact on perceived ease of use, perceived usefulness and
insignificant impact on behavioral intention. Additionally, external factors such as privacy and cost significantly impacted doctors’ behavioral intention to use. Moreover, doctors’ computer self-efficacy significantly influenced the perceived ease of use,
perceived usefulness and behavioral intention to use. |
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Ali, H, Kondapally, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
In May, after a cluster of seven COVID-19 cases was identified in a rural Ohio Amish community, access to testing was
increased. Among 30 additional residents tested by RT-PCR), 23 (77%) received positive test results for SARS-CoV-2. Rapid and sustained transmission of SARS-CoV-2 was associated with multiple social gatherings. Some community members were concerned about having
to follow critical mitigation strategies, including social distancing and mask wearing. COVID-19 outbreaks in communities where social gatherings are common might be prevented by fostering collaborations and trust between the community and local health departments,
sharing culturally and linguistically responsive health messages that emphasize protecting family and community members through established communication networks, and ensuring timely and convenient access to testing. |
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Almagro, M, Orane-Hutchinson, et al |
Journal of Urban Economics |
Epidemiology| Épidémiologie Transmission |
We perform our analysis over a range of several weeks to evaluate how different channels interact with the progression
of the pandemic and the stay-at-home order. While the coefficient magnitudes of many occupations and demographics decrease, we find evidence consistent with higher intra-household contagion over time. Finally, our results also suggest that crowded spaces play
a more important role than population density in the spread of COVID-19. |
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Ames-Guerrero, Rita, Barreda-Parra, et al |
medRxiv |
Mental Health |
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The aim of this study was to conduct a psychometric analysis of the Goldberg's GHQ-28 through a sample of Peruvian
adults using confirmatory factor analysis. 434 individuals have been examined, studying the goodness and structure of the Goldberg GHQ-28 questionnaire. Result: There are high levels of anxiety (X=1.01) and social dysfunction (X=1.21) in the assessed sampling. |
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Visceral leishmaniasis in an Ethiopian
patient with COVID-19: a case report |
Amogne, Melaku Taye, Huluka, et al |
Research Square prepub |
Clinical data| Données cliniques |
We discuss the clinical and public health implications of COVID-19 and Leishmania donovani co-infection. Case presentation
An 18 years old male patient from Northwest Ethiopia diagnosed with COVID-19 and concomitant visceral leishmaniasis that ended in a fatal outcome. It is of crucial importance that clinicians have a high index of suspicion for a combination of COVID-19 and
visceral leishmaniasis in endemic areas. |
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An, Hyunsu, Park, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We used a hidden Markov model-based tool to identify distant viral homologs of human proteins. Also, we utilized experimentally
determined and modeled protein structures of SARS-CoV-2 and human proteins to find homologous protein structures between them. Overall, from 8,138 SARS-CoV-2 genomes, we identified 3,238 potentially cross-reactive B-cell epitopes covering six human proteins
and 1,224 potentially cross-reactive T-cell epitopes covering 285 human proteins. To visualize the predicted cross-reactive T-cell and B-cell epitopes, we developed a web-based application. The web application enables researchers to explore potential cross-reactive
SARS-CoV-2 epitopes alongside custom peptide vaccines. |
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Gastrointestinal Symptoms Onset in COVID-19 Patients in Wuhan, China |
An, P, Chen, et al |
Dig Dis Sci |
Clinical data| Données cliniques |
We retrospectively reviewed 205 COVID-19 cases. A total of 171 patients with classic symptoms (group A) and 34 patients
with only GI symptoms (group B) were included. In patients with classical COVID-19 symptoms, GI symptoms occurred more frequently in severe cases compared to non-severe cases. In group B, 91.2% (31/34) patients were non-severe, while 73.5% (25/34) patients
had obvious infiltrates in their first CT scans. Compared to group A, group B patients had a prolonged time to clinic services (5.0 days vs. 2.6 days, p < 0.01) and a longer time to a positive viral swab normalized to the time of admission (6.9 days vs. 3.3
days, respectively, p < 0.01). |
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Annane, D, Heming, et al |
EClinicalMedicine |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We present results from a nonrandomized proof-of-concept study of complement C5 inhibitor eculizumab for treatment
of severe COVID-19. Findings from this proof-of-concept study suggest eculizumab may improve survival and reduce hypoxia in patients with severe COVID-19. |
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Unexpected detection of SARS-CoV-2 antibodies in the prepandemic period in Italy |
Apolone, G, Montomoli, et al |
Tumori |
Epidemiology| Épidémiologie Immunology | Immunologie |
We investigated the presence of SARS-CoV-2 receptor-binding domain (RBD)-specific antibodies in blood samples of 959
asymptomatic individuals enrolled in a prospective lung cancer screening trial between September 2019 and March 2020 to track the date of onset, frequency, and temporal and geographic variations across the Italian regions. SARS-CoV-2 RBD-specific antibodies
were detected in 111 of 959 (11.6%) individuals, starting from September 2019 (14%), with a cluster of positive cases (>30%) in the second week of February 2020 and the highest number (53.2%) in Lombardy. This study shows an unexpected very early circulation
of SARS-CoV-2 among asymptomatic individuals in Italy several months before the first patient was identified, and clarifies the onset and spread of the COVID-19 pandemic. |
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Prior presumed coronavirus infection reduces COVID-19 risk: A cohort study |
Aran, D, Beachler, et al |
Journal of Infection |
Epidemiology| Épidémiologie |
Immunological cross-reactivity between common cold coronaviruses (CCC) and SARS-CoV-2 might account for the reduced
incidence of COVID-19 in children. After adjusting for age, gender and care seeking behavior, we identified that individuals with diagnoses for common cold symptoms, including acute sinusitis, bronchitis, or pharyngitis in the preceding year had a lower risk
of testing positive for SARS-CoV-2 (OR=0.76, 95%CI=0.75, 0.77). |
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Open-care telemedicine in ophthalmology during the COVID-19 pandemic: a pilot
study |
Arntz, A, Khaliliyeh, et al |
Archivos de la Sociedad Espanola de Oftalmologia |
Healthcare Response | Réponse des soins de santé |
To report a pilot experience of telemedicine in ophthalmology in open-care modality (i.e. direct video call), in a
confinement period due to the COVID-19 pandemic. Open-care modality of telemedicine in ophthalmology during the pandemic period is a useful instrument to filter potential face-to-face consultations, either elective or emergency, and potentially reduce the
risk of COVID-19 infection. |
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Ashish, A, Unsworth, et al |
BMJ open respiratory research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this retrospective case-controlled study was to evaluate the role of continuous positive air pressure
(CPAP) in the management of respiratory failure associated with COVID-19 infection in the UK. CPAP was found to be significantly associated with lower risk of death in patients with hospital stay equal to, or below 7 days. However, for longer hospitalisation
CPAP was found to be associated with increased risk of death. Predictors were age, intubation, hypertension and the residency from care homes, which were found to be statistically significantly associated with patient's death/discharge. |
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Automatic COVID-19 Detection from chest radiographic
images using Convolutional Neural Network |
Asif, Sohaib, Amjad, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Deep learning is one of the most powerful AI tools available, so we recommend creating a convolutional neural network
to detect COVID-19 positive patients from chest radiographs. Our model has been trained with 820 chest radiographic images (excluding data augmentation) collected from 3 databases, with a classification accuracy of 99.61% (training accuracy of 99.59%), the
sensitivity of 99.21%, and specificity of 99.29 %, proved that our model has become a reliable COVID-19 detector. |
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Ates, AA, Alomari, et al |
Brazilian oral research |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to assess the differences, if any, between general dental practitioners (GDPs) and endodontists,
in the diagnosis and treatment of endodontic emergencies during the worldwide outbreak of COVID-19. The most relevant findings in our survey were the differences between endodontists and GDPs in diagnosis, precheck triage, deep caries excavation procedures,
and endodontic emergency pain relief strategies. |
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Bal, Antonin, Destras, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The H69 and V70 deletions in SARS-CoV-2 spike protein have been detected in mink and human infections. We found that
these deletions resulted in a false negative result for the spike target of a commercial RT-PCR assay. From August 3rd to November 1st, 39/6964 (0.56%) of positive tests performed in Lyon, France, displayed a S negative profile suggesting a limited circulation
of the deleted variant. This RT-PCR assay could be useful to address the risk of the mink variant spreading. |
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Balkrishna, A, Mittal, et al |
Curr Pharm Biotechnol |
Therapeutics| Thérapeutique |
Natural moieties obtained from medicinal plants were analysed for their potency to target PLpro of SARS-CoV-2 by molecular
docking study and were compared with synthetic analogs named as remdesivir, chloroquine and favipiravir. The stability of complexes of top hits was analysed by MD Simulation and interaction energy was calculated. Nimbocinol (-7.6 Kcal/mol) and sage (-7.3 Kcal/mol)
exhibited maximum BA against PLpro SARS-CoV-2 as evident from molecular docking study which was found to be even better than remdesivir (-6.1 Kcal/mol), chloroquine (-5.3 Kcal/mol) and favipiravir (-5.7 Kcal/mol). Both nimbocinol-PLpro and sage-PLpro SARS-CoV-2
complex exhibited stable conformation during MD Simulation of 101ns at 310 K and potential, kinetic and electrostatic interaction energies were computed which was observed to be concordant with results of molecular docking study. Present study revealed that
active constituents of Azadirachta indica and Salvia officinalis can be potentially used to target SARS-CoV-2 by hindering its replication process. |
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Surgical management protocol during the COVID-19 pandemic in an Italian non-referral
center |
Balla, A, De Carlo, et al |
Minerva Chir |
Healthcare Response | Réponse des soins de santé |
Aim is to report our surgical management protocol during the COVID-19 pandemic in an Italian non-referral center. During
the study period 41 surgical procedures (24 electives, 17 emergency surgical procedures) underwent surgery in comparison to 99 procedures in 2019. Stratified procedures in elective and emergency surgery, and based on the indication for surgery, the only statistically
significant difference was observed in the elective surgery regarding the abdominal wall surgery (0 vs. 13 procedures, p=0.0339). Statistically significant differences were not observed regarding the colorectal and the breast oncologic surgery. The pandemic
was responsible for the reduction in number of procedures performed, anyway for the oncologic surgery a statistically significant volume reduction in comparison to 2019 was not observed. |
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Batista, AdrianoA, Horácio da Silva, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this work, we adapt the epidemiological SIR model to study the evolution of the dissemination of COVID-19 in Germany
and Brazil. We also propose a simple probabilistic method for the evolution of the active cases that is instrumental for the automatic estimation of parameters of the epidemiological model. We obtained statistical estimates of the active cases based the probabilistic
method and on the confirmed cases data. From this estimated time series we obtained a time-dependent contagion rate, which reflects a lower or higher adherence to social distancing by the involved populations. By also analysing the data on daily deaths, we
obtained the daily lethality and recovery rates. We validate our epidemiological model by fitting the official data of confirmed, recovered, death, and active cases due to the pandemic with the theoretical predictions. |
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Fatal SARS-CoV-2 Inflammatory Syndrome and Myocarditis in an Adolescent: A Case
Report |
Beaudry, JT, Dietrick, et al |
Pediatr Infect Dis J |
Clinical data| Données cliniques |
We report a fatal case of confirmed COVID-19 with hyperinflammatory features concerning for both multi-inflammatory
syndrome in children (MIS-C) and primary COVID-19. This case highlights the ambiguity in distinguishing between these two entities in a subset of pediatric patients with COVID-19-related disease and the rapid decompensation these patients may experience. |
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Benfaremo, D, Perini, et al |
European journal of internal medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
we report the experience of our tertiary referral center, located in central Italy, during the epidemic of SARS-CoV-2,
focusing on the incidence and severity of COVID-19 in a large cohort of patients with systemic autoimmune diseases treated with several immunosuppressive drugs. Among symptomatic 10 patients, 4 (40%) underwent nasopharyngeal swab and 2 (0.65%%) resulted positive
for SARS-CoV-2 and developed COVID-19, an incidence comparable to that reported in the general population of the Marche region (0.53%). |
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PMC7643628; SARS-CoV-2 cell receptor gene ACE2 -mediated immunomodulation in breast
cancer subtypes |
Bhari, VK, Kumar, et al |
Biochem Biophys Rep |
Immunology | Immunologie |
In light of the ACE-2 as an important contributor of COVID-19 global, we analyzed correlation between ACE2 and tumor
immune infiltration (TIL) level and the type markers of immune cells were investigated in breast cancer subtypes by using TIMER database. Our findings shed light on the immunomodulatory role of ACE2 in the luminal A subtype which may play crucial role in imparting
therapeutic resistance in this cancer subtype. |
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Interhospital transport of COVID-19 patients on ECMO and comparison with historic
controls |
Blanco-Schweizer, P, Sánchez-Ballesteros, et al |
Medicina Intensiva |
Healthcare Response | Réponse des soins de santé |
The aim of the study is to evaluate the feasibility, efficacy and safety of interhospital transport of patients on
ECMO during the COVID-19 outbreak. The main finding of our study is that retrieval of COVID-19 patients on ECMO during the outbreak is feasible and safe in the setting of a previously well-established mobile ECMO program. In conclusion, transport of COVID-19
patients on ECMO is feasible and safe in a regional ECMO center. |
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Bojkova, D, Bechtel, et al |
Cells |
Therapeutics| Thérapeutique |
Herein, we showed that the protease inhibitor aprotinin (but not the protease inhibitor SERPINA1/alpha-1 antitrypsin)
inhibited SARS-CoV-2 replication in therapeutically achievable concentrations. An analysis of proteomics and translatome data indicated that SARS-CoV-2 replication is associated with a downregulation of host cell protease inhibitors. Hence, aprotinin may compensate
for downregulated host cell proteases during later virus replication cycles. Aprotinin displayed anti-SARS-CoV-2 activity in different cell types and against four virus isolates. |
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Bonasera, Aldo |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
A two-step model for the rise and decay of the COVID-19 is applied to the Fall resurgence of COVID-19 in Italy. Data
starting from October 6 to the end of December 2020 are compared to the same time interval in Italy starting from the complete lockdown on March 14,2020. The model predicts more than 130,000 deceased by the end of the year 2020 if no effective measures are
taken. If similar measures to the March ones are quickly adopted, the number of deceased may decrease to over 40,000. The situation is extremely serious and requires collaboration from everyone starting from wearing masks and other protections when social
distancing is not feasible. |
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Brotons, P, Launes, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Immunology | Immunologie |
A cross-sectional seroprevalence study was conducted with prospective recruitment of 381 family households including
381 first-reported PCR-positive adult cases and 1,084 contacts (672 children, 412 adults). SARS-CoV-2 infection seroprevalence rates were 17.6% (118/672) in children and 18.7% (77/335) in adult contacts (p=0.64). Among first-reported cases, seropositivity
rates varied from 84.0% in adults previously hospitalized and tested within 6 weeks since the first positive PCR result to 31.5% in those not hospitalized and tested after that lag time (p<0.001). Nearly all (99.9%) positive pediatric contacts were asymptomatic
or had mild symptoms. Adult antibody protection against SARS-CoV-2 seems to be weak at early convalescence and beyond 6 weeks post-infection confirmation, especially in cases that have experienced mild disease. |
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Impact of COVID-19 on nursing time in intensive care units in Belgium |
Bruyneel, A, Gallani, et al |
Intensive and Critical Care Nursing |
Healthcare Response | Réponse des soins de santé |
This study was a retrospective observational study that evaluated the nurse-patient ratio required by COVID-19 patients
and to identify the factors that influence nursing in this context in Belgium. The Nursing Activities Score (NAS) was significantly higher among the COVID-19 patients than in the control group (p = <0.0001). In the COVID-19 group, these higher scores were
also observed per shift and uniformly across the three hospitals. COVID-19 patients required more time in the activities of monitoring and titration (χ2 = 457.60, p = <0.0001), mobilisation (χ2 = 161.21, p = <0.0001), and hygiene (χ2 = 557.77, p = <0.0001).
Factors influencing nursing time measured by NAS in the COVID-19 patients were age <65 years old (p = 0.23), the use of continuous venovenous hemofiltration (p = 0.002), a high APACHE II score (p = 0.006) and patient death (p = 0.002). A COVID-19 diagnosis
was independently associated with an increase in nursing time (OR = 4.8, 95% CI:3.6–6.4). Patients hospitalised in the ICU due to COVID-19 require significantly more nursing time and need an average ratio of almost 1:1. |
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Caycho-Rodríguez, T, Barboza-Palomino, et al |
Ansiedad y Estres |
Mental Health |
|
The objective of the study was to translate and validate the Coronavirus Anxiety Scale (CAS) into Spanish. The Spanish
version of the CAS has evidence of validity and reliability to measure anxiety by COVID-19 in a sample of Peruvian university students. |
|
|
Chai, N, Tang, et al |
Surg Endosc |
Healthcare Response | Réponse des soins de santé |
In this study, we aimed to evaluate the influence of the COVID-19 epidemic on the GI endoscopy practice in China. With
the influence of the COVID-19 epidemic, there has been significant decease of GI endoscopy practice in mainland China. |
|
|
Chakraborty, S, Mali, et al |
Expert Systems with Applications |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
A novel method is proposed in this work to segment the radiological images for the better explication of the COVID-19
radiological images. The proposed method will be known as SuFMoFPA (Superpixel based Fuzzy Modified Flower Pollination Algorithm). The type 2 fuzzy clustering system is blended with this proposed approach to get the better-segmented outcome. Obtained results
are quite promising and outperforming some of the standard approaches which are encouraging for the practical uses of the proposed approach to screening the COVID-19 patients. |
|
|
Modelling transmission and control of the COVID-19 pandemic in Australia |
Chang, SL, Harding, et al |
Nat Commun |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique |
This study reports the results of agent-based modelling using a fine-grained computational simulation of the ongoing
COVID-19 pandemic in Australia. This model is calibrated to match key characteristics of COVID-19 transmission. We apply the model to compare several intervention strategies, including restrictions on international air travel, case isolation, home quarantine,
social distancing with varying levels of compliance, and school closures. School closures are not found to bring decisive benefits unless coupled with high level of social distancing compliance. We report several trade-offs, and an important transition across
the levels of social distancing compliance, in the range between 70% and 80% levels, with compliance at the 90% level found to control the disease within 13-14 weeks, when coupled with effective case isolation and international travel restrictions. |
|
ACE2-Targeting Monoclonal Antibody As A "Pan" Coronavirus
Blocker In Vitro and In A Mouse Model |
Chen, Yuning, Zhang, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique Animal model | Modèle animal |
Here we report a monoclonal antibody 3E8 targeting human angiotensin-converting enzyme 2 (ACE2) neutralized pseudo-typed
coronaviruse SARS-CoV-2, SARS-CoV-2-D614G, SARS-CoV and HCoV-NL63, without affecting physiological activities of ACE2 or causing toxicity in mouse model. 3E8 also blocked live SARS-CoV-2 infection in vitro and in a mouse model of COVID-19. Cryo-EM studies
revealed the binding site of 3E8 on ACE2 and identified Histone 34 of ACE2 as a critical site of anti-viral epitope. |
|
Detection of COVID-19 Using Deep Learning Algorithms on Chest Radiographs |
Chiu, WHK, Vardhanabhuti, et al |
Journal of thoracic imaging |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The purpose of this study was to evaluate the performance of a deep learning (DL) algorithm for the detection of COVID-19
on chest radiographs (CXR). The DL algorithm achieved an AUC of 0.81, sensitivity of 0.85, and specificity of 0.72 in detecting COVID-19 using RT-PCR as the reference standard. The algorithm significantly outperforms human readers with higher sensitivity. |
|
Validation and testing of a method for detection
of SARS-CoV-2 RNA in healthy human stool |
Coryell, Michael, Iakiviak, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We sought to adapt and validate an available test specifically for detection of SARS-CoV-2 in human stool. Methods
Stool samples were spiked with inactivated SAR-CoV-2 virus for development and validation of the assay. A modified version of the CDC rRT-PCR SARS-CoV-2 test was used for detection of virus. Findings The lower limit of detection (LoD) of the assay was found
to be 3000 viral RNA copies per gram of original stool sample, with 100% detection across 20 replicates assessed at this concentration. Thirty contrived SARS-CoV-2 samples were tested by a second laboratory and were correctly identified as positive or negative
in at least one of two rounds of testing. Additionally, we detected SARS-CoV-2 RNA in the stool of known COVID-19 positive individuals using this method. |
|
Trends and diagnostic value of D-dimer levels in patients hospitalized with coronavirus
disease 2019 |
Creel-Bulos, C, Liu, et al |
Medicine (Baltimore) |
Clinical data| Données cliniques |
The purpose of our study is to describe clinical outcomes and to examine trends in D-dimer levels as it relates to
venous thromboembolic events (VTE) and mortality. 115 patients admitted with confirmed COVID-19 cases with plasma D-dimer levels were included in our retrospective analysis. Hypertension was present in 72% and diabetes in 52%. Mean duration of hospitalization
was 19 ± 11 days for 54% patients. VTE was diagnosed in 23% patients. Median D-dimer within the first 7 days of hospitalization was higher, peak D-dimer level of >2500 ng/mL and a rate of change exceeding 150 ng/mL/d were predictive of future diagnosis of
VTE. Rise in D-dimer >2000 ng/mL within any 24 hour period through hospital day 10 had 75% sensitivity and 74% specificity for diagnosis of VTE. Both magnitude and rate of rise in d-dimer within the first 10 days of hospitalization are predictive of diagnosis
of VTE but not mortality. |
|
G-Quadruplexes Are Present in Human Coronaviruses Including SARS-CoV-2 |
Cui, H, Zhang, et al |
Frontiers in Microbiology |
Coronavirology| Coronavirologie |
In the current study, we have predicted that all seven human coronaviruses harbor G-quadruplex sequences. Conserved
G-quadruplex sequences in SARS-CoV and SARS-CoV-2 were analyzed and verified by circular dichroism (CD) spectroscopy and Thioflavin T fluorescence assay. Similar to SARS-CoV, SARS-CoV-2 encodes an nsP3 protein, which is predicted to associate with G-quadruplexes.
Targeting G-quadruplex sequences in the SARS-CoV-2 genome by G-quadruplex ligands could be a new way to conquer COVID-19. |
|
pyPOCQuant - A tool to automatically quantify Point-Of-Care
Tests from images |
Cuny, Andreas Patrick, Rudolf, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Lateral flow Point-Of-Care Tests (POCTs) are a valuable tool for rapidly detecting pathogens and the associated immune
response in humans and animals. Here we present pyPOCQuant, an open-source tool implemented in Python 3 that can robustly and reproducibly analyze POCTs from digital images and return an unbiased and quantitative measurement of the POCT test lines. |
|
Curreli, Francesca, Victor, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here we report the design of four stapled peptides based on the ACE2 helix, which is expected to bind to SARS-CoV-2
and prevent the binding of the virus to the ACE2 receptor and disrupt the infection. We have evaluated the peptides in a pseudovirus based single-cycle assay in HT1080/ACE2 and human lung cells A549/ACE2, overexpressing ACE2. Three of the four stapled peptides
showed potent antiviral activity in HT1080/ACE2 (IC50: 1.9 – 4.1 µM) and A549/ACE2 cells (IC50: 2.2 – 2.8 µM). The linear peptides NYBSP-C and the double-stapled peptide StRIP16, used as controls, showed no antiviral activity. Most significantly, none of the
stapled peptides show any cytotoxicity at the highest dose tested. We also evaluated the antiviral activity of the peptides by infecting Vero E6 cells with the replication-competent authentic SARS-CoV-2 (US_WA-1/2020). NYBSP-1 was the most efficient preventing
the complete formation of cytopathic effects (CPEs) at an IC100 17.2 µM. NYBSP-2 and NYBSP-4 also prevented the formation of the virus-induced CPE with an IC100 of about 33 µM. |
|
|
Dabbagh, A, Rajaei, et al |
Trials |
RCT |
Trial Protocol. |
|
|
Long-term survival of SARS-CoV-2 on salmon as a source for international transmission |
Dai, M, Li, et al |
J Infect Dis |
Transmission zoonoses |
Although the surface stability of SARS-CoV-2 in different environmental conditions was reported, we are curious about
the survival time of SARS-CoV-2 on meat and fish products. Imported and exported fish must be transported under a low-temperature (e.g., 0~4°C) environment. Under such condition, SARS-CoV-2-contaminated fish from one country can be easily transported to another
country within one week and, thus, may serve as a source for international transmission of SARS-CoV-2. This calls for strict inspection and detection of SARS-CoV-2 as an important new protocol in fish transportation. |
|
Danielle Dias Conte, Danielle Dias, Carvalho, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We evaluated three different commercial point-of-care (POC) LFIAs for anti-SARS-CoV-2 IgM and IgG detection in capillary
whole blood of 100 healthcare workers (HCW) previously tested by RT-PCR: 1) COVID-19 IgG/IgM BIO (Bioclin, Brazil), 2) Diagnostic kit for IgM/IgG Antibody to Coronavirus (SARS-CoV-2) (Livzon, China); and 3) SARS-CoV-2 Antibody Test (Wondfo, China). A total
of 84 positives and 16 negatives HCW were tested. Overall detection was 85.71%, 47.62%, and 44.05% for Bioclin, Livzon, and Wondfo, respectively, with a specificity of 100%, and 98.75% for Livzon on storage serum samples. Bioclin was more sensitive (p<0.01),
regardless of the DAS. Thus, the Bioclin can be used as a POC test to monitor SARS-CoV-2 seroconversion in HCW. |
|
|
Daoud, Z, McLeod, et al |
Frontiers in Cellular and Infection Microbiology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The objective of this work was to validate two commercial kits for the detection of IgM and IgG using lateral flow
immunoassay tests and to study the effect of the combination of both serology kits for better detection of immunoglobulins. A total of 195 patients presenting with respiratory symptoms suggestive of infection with SARS-Cov-2 were subject to serology and molecular
testing. The results show sensitivities for IgM detection varying between 58.9 and 66.2% for the kits alone and 87.7% of the combination of both kits. IgG detection was not significantly affected by this combination. |
|
|
Das, A, Ghosh, et al |
Sustainable Cities and Society |
Epidemiology| Épidémiologie |
The paper aims to examine the impact of living environment deprivation on COVID-19 hotspot in Kolkata megacity. COVID-19
hotspot maps were prepared using Getis-Ord-Gi* statistic and index of multiple deprivations (IMD) across the wards were assessed using Geographically Weighted Principal Component Analysis (GWPCA).Five count data regression models such as Poisson regression
(PR), negative binomial regression (NBR), hurdle regression (HR), zero-inflated Poisson regression (ZIPR), and zero-inflated negative binomial regression (ZINBR) were used to understand the impact of living environment deprivation on COVID-19 hotspot in Kolkata
megacity. The findings of the study revealed that living environment deprivation was an important determinant of spatial clustering of COVID-19 hotspots in Kolkata megacity and zero-inflated negative binomial regression (ZINBR) better explains this relationship
with highest variations (adj. R2: 71.3 %) and lowest BIC and AIC as compared to the others. |
|
|
Parents' Likelihood to Vaccinate Their Children and
Themselves Against COVID-19 |
Davis, MatthewM, Zickafoose, et al |
medRxiv |
Public Health response| Interventions de santé publique |
Methods We fielded a national household survey in English and Spanish from June 5-10, 2020 (n=1,008). Parents were
asked about their likelihood of immunizing their children and themselves against COVID-19. Overall, 63% of parents (95% CI: 59%, 66%) were likely to vaccinate their children against COVID-19, and 60% (57%, 64%) were likely to get a vaccine themselves. In
multivariable analyses, younger parents were significantly less likely than older parents to vaccinate their children and themselves against COVID-19, as were parents with high school or less education compared with parents with bachelor's degrees and non-Hispanic
White parents compared with Hispanic parents. |
|
Virus-Negative Myopericarditis in Human
Coronavirus Infection: Report From an Autopsy Series |
Del Nonno, F, Frustaci, et al |
Circ Heart Fail |
Clinical data| Données cliniques |
Report cardiac autopsy findings of 9 patients with COVID-19 infection and pneumonitis who died from cardiac shock or
sudden death during hospitalization. |
|
Demichev, Vadim, Tober-Lau, et al |
medRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
Here, we characterize the time-dependent progression of COVID-19 through different stages of the disease, by measuring
86 accredited diagnostic parameters and plasma proteomes at 687 sampling points, in a cohort of 139 patients during hospitalization. Our study provides a deep and time resolved molecular characterization of COVID-19 disease progression, and reports biomarkers
for risk-adapted treatment strategies and molecular disease monitoring. Our study demonstrates accurate prognosis of COVID-19 outcome from proteomic signatures recorded weeks earlier. |
|
|
Derwand, R, Scholz, et al |
International journal of antimicrobial agents |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The aim of this study was to describe the outcomes of patients with coronavirus disease 2019 (COVID-19) in the outpatient
setting after early treatment with zinc, low-dose hydroxychloroquine and azithromycin (triple therapy) dependent on risk stratification. Of 141 treated patients, 4 (2.8%) were hospitalised, which was significantly fewer (P < 0.001) compared with 58 (15.4%)
of 377 untreated patients [odds ratio (OR) = 0.16, 95% confidence interval (CI) 0.06–0.5]. One patient (0.7%) in the treatment group died versus 13 patients (3.4%) in the untreated group (OR = 0.2, 95% CI 0.03–1.5; P = 0.12). No cardiac side effects were observed.
Risk stratification-based treatment of COVID-19 outpatients as early as possible after symptom onset using triple therapy, including the combination of zinc with low-dose hydroxychloroquine, was associated with significantly fewer hospitalisations. |
|
|
Di Nisio, M, Potere, et al |
European journal of internal medicine |
Clinical data| Données cliniques Therapeutics| Thérapeutique Immunology | Immunologie |
The aim of this study was to evaluate the effects of subcutaneous tocilizumab, a recombinant humanized monoclonal antibody
against the interleukin-6 receptor on coagulation parameters. Subcutaneous tocilizumab was associated with significant improvement of blood coagulation parameters independently of thromboprophylaxis dose. |
|
|
Dierckx, Tim, Van Elslande, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The present study investigated blood metabolites in order to elucidate how infection with SARS-CoV-2 can lead to such
a variety of pathologies and what common ground they share. A total of 251 blood metabolite measures and ratios were assessed using nuclear magnetic resonance spectroscopy and tested for association to disease severity. Our results point to systemic metabolic
biomarkers for COVID-19 severity that make strong targets for further fundamental research into its pathology (e.g. phenylalanine and omega-6 fatty acids). |
|
|
Dollard, P, Griffin, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
As an early effort to prevent importation of SARS-CoV-2, CDC established entry screening at designated airports for
passengers from certain countries. Passenger entry screening was resource-intensive with low yield of laboratory-diagnosed COVID-19 cases (one case per 85,000 travelers screened). Contact information was missing for a substantial proportion of screened travelers
in the absence of manual data collection. Symptom-based screening programs are ineffective because of the nonspecific clinical presentation of COVID-19 and asymptomatic cases. |
|
|
Doussot, A, Ciceron, et al |
Ann Surg |
Healthcare Response | Réponse des soins de santé |
The aim of this prospective cohort study was to define whether rapidly reallocating health care workers not experienced
with prone and supine positioning (PP) for performing PP in ICU is feasible and safe. Among 117 patients admitted to ICU, 57.3% required PP. Overall, complication occurred in 34 PP (8.8%) and led to PP cancelation in 4 patients (1%). Regarding health care
workers safety, four health care workers presented with potential COVID-19 related symptoms and none was positive. |
|
|
Forecasting Emergency Department Capacity Constraints for COVID Isolation Beds |
Drysdale, Erik, Singh, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins
de santé |
Prompted by new COVID-related capacity constraints placed on our pediatric hospital's emergency department, we developed
an hourly forecasting tool to make predictions over a 24 hour window. These forecasts would give our hospital sufficient time to be able to martial resources towards expanding capacity and augmenting staff. Using Gaussian Process Regressions (GPRs), we obtain
strong performance for both point predictions (average R-squared: 82%) as well as classification accuracy when predicting the ordinal tiers of our hospital's capacity (average precision/recall: 82%/74%). Compared to traditional regression approaches, GPRs
not only obtain consistently higher performance, but are also robust to the dataset shifts that have occurred throughout 2020. |
|
The Fractional Epidemics Theory: Managing and Ending
an Epidemic |
Duclos, TheodoreG, Reichert, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
Susceptible Infectious Recovered (SIR) models are widely used for estimating the dynamics of epidemics and project
that social distancing 'flattens the curve', i.e., reduces but delays the peak in daily infections, causing a longer epidemic. Based on these projections, individuals and governments have advocated lifting containment measures such as social distancing to
shift the peak forward and limit societal and economic disruption. Paradoxically, the COVID-19 pandemic data exhibits phenomenology opposite to the projections of the SIR models. Here, we present a new model that replicates the observed phenomenology and quantitates
pandemic dynamics with simple and actionable analytical tools for policy makers. Specifically, it offers a prescription of achievable and economically palatable measures for ending an epidemic. |
|
The repurposed drugs suramin and quinacrine inhibit
cooperatively in vitro SARS-CoV-2 3CLpro</sup> |
Eberle, RaphaelJ, Olivier, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The results described in this study demonstrate the inhibitory potential of quinacrine and suramin against SARS-CoV-2
main protease (3CLpro). Quinacrine and suramin molecules present a competitive and non-competitive mode of inhibition, respectively, with IC50 and KD values in low μM range. Using docking and molecular dynamics simulations we identified a possible binding
mode and the amino acids involved in these interactions. Our results suggested that suramin in combination with quinacrine showed promising synergistic efficacy to inhibit SARS-CoV-2 3CLpro. |
|
Healthcare providers experience of working during the COVID-19 pandemic: A qualitative
study |
Eftekhar Ardebili, M, Naserbakht, et al |
American Journal of Infection Control |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to undertake an in-depth exploration of the experiences of health-care staff working during
the COVID-19 crisis in Iran. Based on the results the aid should be focused on the various stages and should be individual-centered. Such interventions are crucial to sustain workers in their ability to cope throughout the duration of the pandemic. |
|
Efthimiou, I |
Urology journal |
Healthcare Response | Réponse des soins de santé |
Our objective is to determine whether, during the COVID-19 period, there has been any modification in urological services.
The number of the operations was reduced by 43-65% from March-May 2020. Our surgical list had a waiting time of 6-8 weeks before the pandemic and now the waiting time has expanded to 12 weeks. Urological emergencies were reduced about 23-57%. Admission rates
were dropped 10-51%. Visits in outpatient clinics were reduced 100-50% and outpatient procedures for elective cases were all deferred. Unfortunately, the hospital did not offer synchronous telehealth appointments. Bladder instillations of BCG or chemotherapeutics
were not suspended but start of new cases had a delay of 2-3 weeks. There were no cases of COVID-19 in our department. |
|
|
Elias, MD, McCrindle, et al |
CJC Open |
Healthcare Response | Réponse des soins de santé |
We surveyed the inpatient MIS-C management approaches of the members of the International Kawasaki Disease Registry
across 38 institutions and 11 countries. Among the respondents, 56% reported using immunomodulatory treatment for all MIS-C patients, regardless of presentation. Every respondent reported use of intravenous immunoglobulin (IVIG), including 53% administering
IVIG in all patients. Steroids were most often used for patients with severe clinical presentation or lack of response to IVIG, and only a minority used steroids in all patients (14%). Acetylsalicylic acid was frequently used among respondents (91%), including
anti-inflammatory and/or antiplatelet dosing. Respondents reported use of prophylactic anticoagulation, especially in patients at higher risk for venous thromboembolism, and therapeutic anticoagulation, particularly for patients with giant coronary artery
aneurysms. |
|
|
Endler, M, Al-Haidari, et al |
Acta Obstet Gynecol Scand |
Healthcare Response | Réponse des soins de santé |
We aimed to give a global overview of trends in access to sexual and reproductive health and rights (SRHR) during the
Covid‐19 pandemic and what is being done to mitigate its impact. The survey was answered by 51 people representing 29 countries. 86% reported that access to contraceptive services due to Covid‐19, corresponding figures for surgical and medical abortion were
62% and 46%. The content analysis showed that i) prioritizations in health service delivery at the expense of SRHR, ii) lack of political will, iii) the detrimental effect of lock‐down, and iv) the suspension of sexual education, were threats to SRHR access
(theme 1). Requirements to mitigate these threats (theme 2) were i) political will and support of universal access to SRH services, ii) the sensitization of providers, vii) free public transport, and viii) physical protective equipment. A contrasting third
theme was the state of exception of the Covid‐19 pandemic as a window of opportunity to push forward women´s health and rights. |
|
|
Analysis of SARS-CoV-2 in the air of an ICU dedicated to covid-19 patients |
Escudero, D, Barrera, et al |
Medicina Intensiva |
Transmission Infection Prevention and Control/ Prévention et contrôle des infections
(IPAC/PCI) Healthcare Response | Réponse des soins de santé |
We proposed to analyze the presence of SARS-CoV-2 in the air of 2 ICU units and the pulmonology ward dedicated to treating
covid-19 patients. The extraction equipment was placed on the ground, near the patient's head and as far as possible from the air outlet, collecting the air samples for a time of 2-4 h. The entire ICU was equipped with negative pressure of −10 pascals and
had an exchange of 15-20 cycles / h of air. The hospitalization floor had no air renewal. Quantitative RT-PCR analysis did not show detection of the SARS-CoV-2 genome in any of the samples collected by the 2 methods described, so in our study we were unable
to demonstrate the presence of SARS-CoV-2 in the air of the ICU or in the hospital ward. |
|
Esmaeelinejad, M, Mirmohammadkhani, et al |
Brazilian oral research |
Healthcare Response | Réponse des soins de santé |
This study aimed to measure the level of knowledge and attitude of the Iranian dental students towards COVID-19 and
its infection control strategies. In this study, 531 dental students of the clinical course in 32 Iranian universities were included. The mean age of the participants was 23.13 ± 2.29 years. The average percentage of knowledge and attitude scores were 59.7%
(moderate) and 66.0% (neutral), respectively. The association between the attitude of the students and their semesters was statistically significant (r = 0.183, p < 0.001). The age of the students was also significantly associated with their attitudes (r =
0.150, p = 0.001). The outbreak of COVID-19 might resurge due to re-opening of the dental faculties. |
|
|
The sooner the better? Anxiety and deliberate exposure to COVID-19 risk
among young adults in France |
Etilé, Fabrice, Geoffard, et al |
Research Square prepub |
Mental Health |
|
We tested whether anxiety was associated with an increase in willingness to be exposed to the risk of COVID-19 infection
(WiRE) using an online survey administered to 3,110 French individuals aged between 18 and 35 years old during the lockdown period (April 2020). Our results suggest that both the prospect of economic losses and psychological anxiety can undermine young adults’
adherence to physical distancing recommendations. Public policies targeting young adults must consider both their economic situation and their mental health, and they must use uncertainty-reducing communication strategies. |
|
Analysis of COVID-19 evolution in Senegal: impact of health care capacity |
Fall, MouhamedM, Ndiaye, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We consider a compartmental model from which we incorporate a time-dependent health care capacity having a logistic
growth. This allows us to take into account the Senegalese authorities response in anticipating the growing number of infected cases. We highlight the importance of anticipation and timing to avoid overwhelming that could impact considerably the treatment
of patients and the well-being of health care workers. A condition, depending on the health care capacity and the flux of new hospitalized individuals, to avoid possible overwhelming is provided. We also use machine learning approach to project forward the
cumulative number of cases from March 02, 2020, until 1st December, 2020. |
|
SARS-CoV-2 antibody signatures for predicting the
outcome of COVID-19 |
Fan, Xionglin, Lei, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
By taking advantage of a newly developed SARS-CoV-2 proteome microarray, we surveyed IgM/ IgG responses against 20
SARS-CoV-2 proteins in 1,034 hospitalized COVID-19 patients on admission, who were followed till 66 days. We found that high level of IgM against ORF7b at the time of hospitalization is an independent predictor of patient survival, while levels of IgG responses
to 6 non-structural proteins and 1 accessory protein, possess significant predictive power for patient death, even after further adjustments for demographics, comorbidities, and common laboratory markers for disease severity. |
|
Fassy, Julien, Lacoux, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here we describe a quantitative nanofluidic assay based on the Biomark instrument from Fluidigm. This system offers
the possibility of performing 4608 qPCR end-points in a single run, equivalent to 192 clinical samples combined with 12 pairs of primers/probe sets in duplicate, thus allowing the monitoring in addition to SARS-CoV-2 probes of other pathogens and/or host cellular
responses (virus receptors, response markers, microRNAs). Its 10 nL range volume is compatible with sensitive and reproducible reactions that can be easily and cost-effectively adapted to various RT-qPCR configurations and sets of primers/probe. Finally, we
also evaluated the use of inactivating lysis buffers composed of various detergents in the presence or absence of proteinase K to assess the compatibility of these buffers with a direct reverse transcription enzymatic step and we propose several procedures,
bypassing the need for RNA purification. |
|
|
Peginterferon-lambda for the treatment of COVID-19
in outpatients |
Feld, JordanJ, Kandel, et al |
medRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
Methods In this double-blind, placebo-controlled trial, outpatients with laboratory-confirmed COVID-19 were randomized
to a single subcutaneous injection of peginterferon-lambda 180μg or placebo within 7 days of symptom onset or first positive swab if asymptomatic. Findings: The decline in SARS-CoV-2 RNA was greater in those treated with peginterferon-lambda than placebo.
On Day 7, 24 participants in the peginterferon-lambda group had an undetectable viral load compared to 19 in the placebo arm. After controlling for baseline viral load, peginterferon lambda treatment resulted in a 4.12-fold higher likelihood of viral clearance
by Day 7. |
|
Fernández Cruz, M, Álvarez Rodríguez, et al |
Frontiers in Psychology |
Mental Health |
|
The aim of this study is to analyze the students’ cognitive-emotional regulation as well as their beliefs and perceptions
about the pandemic and this lockdown situation. The cognitive strategies used by the students surveyed have allowed them coping with events arising from the pandemic, mandatory isolation and university closure, certainly adaptive and functional, while maintaining
a positive perception of their new living and learning situation. |
|
|
Fillat-Gomà, F, Coderch-Navarro, et al |
BMC Health Serv Res |
Healthcare Response | Réponse des soins de santé |
With critical care experts, authors identified potentially lacking medical equipment and proposed solutions based on
3D printing. The design files for each device was posted online together with their technical and printing specifications, and created a supply chain so that hospitals from the region could request them. Of the requested items, 88.5% were airway consumables
and 11.5% were personal protective equipment. |
|
|
A Retrospective Analysis of the Trends in Acute Appendicitis During the COVID-19 Pandemic |
Finkelstein, P, Picado, et al |
J Laparoendosc Adv Surg Tech A |
Healthcare Response | Réponse des soins de santé |
This retrospective analysis was designed to look at the rates of appendicitis and perforated appendicitis observed
during mandatory “safer at home order”. There were 107 patients, a total of 48 patients presented with acute appendicitis, with 16 perforations, compared with the previous year where 59 patients presented with acute appendicitis, with 10 perforations (33%
versus 17% P = .04). Most patients underwent laparoscopic appendectomy (91%, n = 98), six patients (6%) were managed with intravenous antibiotics and 3 patients (3%) with percutaneous drainage. Patients who perforated had a longer duration of symptoms, white
blood cell count, and longer operative time. There was an overall increased rate of perforated appendicitis seen during quarantine compared with the previous year. |
|
Age-Specific SARS-CoV-2 Infection Fatality and Case
Identification Fraction in Ontario, Canada |
Fisman, David, Drews, et al |
medRxiv |
Epidemiology| Épidémiologie Immunology | Immunologie |
Seroprevalence estimates were derived using retention samples stored by Canadian Blood Services in May 2020. These
were compared to non-long-term care-linked case and fatality data from the same period. Overall IFR was estimated to be 0.80% (0.75 to 0.85%) consistent with estimates from other jurisdictions. IFR increased exponentially with age from 0.01% (0.002 to 0.04%)
in those aged 20-29 years, to 12.71% (4.43 to 36.50%) in those aged 70 and over. We estimated that 5.88 infections (3.70 to 9.21) occurred for every case identified, with a higher fraction of cases identified in those aged 70 and older (42.0%) than those aged
20-29 (9.4%). IFR estimates in those aged 60 and older were identical to pooled estimates from other countries. |
|
Flygare, Oskar, Ivanov, et al |
medRxiv |
Mental Health |
|
Objective: To evaluate physical and mental well-being, subjective mental health, and need for updated psychiatric management
plans in a sample of patients with severe mental illness during the early stages of the COVID-19 pandemic. Design: Cross-sectional study of structured telephone assessments conducted between April 23 and June 30, 2020. Results: Neurodevelopmental disorders,
psychotic disorders, and bipolar disorder were the most common diagnostic categories. The majority of respondents reported no respiratory symptoms (86%), and few reported light (10%) or severe (4%) respiratory symptoms. Similarly, most patients reported no
worsening in psychiatric symptoms (81%). For those who reported a worsening of psychiatric symptoms (19%), the psychiatric management plans that were already in place were deemed appropriate in most cases (16.5%), whereas 22 patients (2.5%) reported a worsening
of psychiatric symptoms that warranted an earlier or immediate follow-up by their psychiatric clinic. |
|
|
Neuraminidase inhibitors rewire neutrophil function
in murine sepsis and COVID-19 patient cells |
Formiga, RodrigoO, Amaral, et al |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
Here, we report that antiviral neuraminidase inhibitors constrain host neuraminidase activity, surface sialic acid
release, ROS production, and NETs released by microbial-activated human neutrophils. In vivo, treatment with Oseltamivir results in infection control and host survival in murine models of sepsis. Moreover, Oseltamivir or Zanamivir treatment of whole blood
cells from severe COVID-19 patients reduces host NEU-mediated shedding of surface sialic acid and neutrophil overactivation. These findings suggest that neuraminidase inhibitors are host-directed interventions to dampen neutrophil dysfunction in severe infections. |
|
"At home, with care": Lessons from New York City Home-based Primary Care practices managing
COVID-19 |
Franzosa, E, Gorbenko, et al |
J Am Geriatr Soc |
Healthcare Response | Réponse des soins de santé |
Cross‐sectional qualitative design using semi‐structured interviews and inductive and deductive thematic analysis on
clinical/medical directors, program managers, nurse practitioners/nursing coordinators and social workers/social work coordinators (n=13) at 6 NYC‐area practices. Participants described care delivery and operational adaptations similar to those universally
adopted across health care settings during COVID‐19, such as patient outreach and telehealth. HBPC‐specific adaptations included mental health services for patients experiencing depression and isolation, using multiple modalities of patient interactions to
balance virtual care with necessary in‐person contact, strategies to maintain patient trust, and supporting team connection of staff through daily huddles and emotional support during the surge of deaths among long‐standing patients. |
|
French, ChristopherT |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
We evaluated a new PARP inhibitor, stenoparib, for which was recently advanced to Stage II clinical trials for treatment
of ovarian cancer. This is an initial report on the activity of stenoparib against human respiratory coronaviruses, including SARS-CoV-2, in vitro. Stenoparib exhibits dose-dependent suppression of SARS-CoV-2 multiplication and spread in Vero E6 monkey kidney
and Calu-3 human lung adenocarcinoma cells. Stenoparib was also strongly inhibitory to multiplication of the HCoV-NL63 human seasonal respiratory coronavirus. Compared to remdesivir, which inhibits the viral replicon subsequent to cell entry, stenoparib is
inhibitory to virus entry and post-entry processes as determined by time-of-addition (TOA) experiments. |
|
|
Determinants of Persistent Post COVID-19 symptoms:
Value of a Novel COVID-19 symptoms score |
Galal, islam, Mohamed-Hussein, et al |
medRxiv |
Epidemiology| Épidémiologie Long-Term Sequelae |
|
Aim of this work is to assess the frequency, patterns and determinants of persistent post COVID-19 symptoms and to
evaluate the value of a proposed Novel COVID-19 symptoms score. Patients with confirmed COVID-19 in the registry were included in a cross sectional study. Results The most frequent constitutional and neurological symptoms were myalgia (60.0%), arthralgia
(57.2%), restriction of daily activities (57.0%), sleeping troubles (50.9%), followed by anorexia (42.6%), chest pain (32.6%), gastritis (32.3%), cough (29.3%) and dyspnea (29.1%). The main determinants of the persistent post COVID-19 symptoms were the need
for oxygen therapy (P<0.001), pre-existing hypertension (P=0.039), chronic pulmonary disorders (P=0.012), and any chronic comorbidity (P=0.004). |
|
Gamberini, L, Tonetti, et al |
Journal of Intensive Care |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The primary objective of this multicenter prospective observational study is to investigate the risk factors associated
with the inability to liberate COVID-19 patients from mechanical ventilation. The secondary objective of this study was the evaluation of risk factors for ICU mortality. Age, SOFA score at ICU admission, CRS, PaO2/FiO2, renal and cardiovascular complications,
and late-onset VAP were all independent risk factors for prolonged mechanical ventilation in patients with COVID-19. Similar results were obtained by the multivariate logistic regression analysis using mortality as a dependent variable. |
|
|
Gao, J, Zhang, et al |
Hong Kong Med J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Reviewed and analysed the epidemiological, demographic, clinical, radiological, and laboratory features of COVID-19
cases presenting from Jan -Mar 2020. Approximately half of the patients were discovered as familial clusters. The mean incubation time was 7 days, and the symptoms were mainly fever, cough, fatigue, and sore throat. Lymphocytopenia was observed predominantly
in patients aged over 60 years. Fifty five patients presented with bilateral pulmonary lesions |
|
|
Gautam, Arunodaya, Dhara, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
In Oct-Nov 2020, 1078 individuals in West Bengal surveyed to evaluate possible acceptance rates, affordability and
factors affecting the acceptance of a vaccine for COVID-19. 77.27 percent of respondents reported that they would be very or very likely to take a vaccine for COVID-19, 5.3 percent don’t want to take vaccine and 12.24 don’t know about their decision. In that
58 percent respondents want to take Indian Vaccine; 19 percent respondents want to take foreign vaccine. Other respondents can take any vaccine. Majority responders want a vaccine in a cost of below 500 INR. |
|
|
Gendrot, M, Andreani, et al |
International journal of antimicrobial agents |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study non-photoactivated methylene blue showed in vitro activity at very low micromolar range with an EC50
(median effective concentration) of 0.30 ± 0.03 μM and an EC90 (90% effective concentration) of 0.75 ± 0.21 μM at a multiplicity of infection (MOI) of 0.25 against SARS-CoV-2 (strain IHUMI-3). Methylene blue (MB) has a 50% cytotoxic concentration (CC50) >100
μM in Vero E6 cells. In comparison, EC50 and EC90 of 1.5 and 3.0 μM for hydroxychloroquine and 20.1 and 41.9 μM for azithromycin. Cmax/EC50 and Cmax/EC90 for MB were estimated at 10.1 and 4.0 after oral and 33.3 and 13.3 after i.v. administration. EC50 and
EC90 values of MB consistent with concentrations observed in human blood. We propose that methylene blue is a promising drug for treatment of COVID-19. |
|
|
Impacts of the COVID-19 Pandemic on Cardiac Rehabilitation
Delivery around the World |
Ghisi, Gabriela Lima de Melo, Xu, et al |
medRxiv |
Public Health response| Interventions de santé publique |
This study describes the implementation of new technologies to ensure their patients receive CR safely, despite the
challenges. Respondents perceived staff (n=488,41.3%) and patient (n=453,38.6%) personal protective equipment, as well as COVID-19 screening (n=414,35.2%) and testing (n=411,35.0%) as paramount to in-person service resumption. |
|
Gittelman, RachelM, Lavezzo, et al |
medRxiv |
Epidemiology| Épidémiologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes Immunology | Immunologie |
We analyzed T-cell and antibody signatures in a large population study of over 2,200 individuals from the municipality
of Vo’, Italy, including 70 PCR-confirmed SARS-CoV-2 cases. These results establish that T cells are a more sensitive, reliable and persistent measure of past SARS-CoV-2 infection than antibody levels at a onvalescent time point . |
|
|
Goldhaber-Fiebert, Jeremy, Holsinger, et al |
medRxiv |
Public health interventions*| Interventions de sant&eacute; publique |
A data set was constructed that enables the characterization of the evolution over time of California state- and country-level
public health orders dealing with COVID-19 from January 1, 2020 through September 30, 2020. |
|
|
Predictors of managers’ mental health during the COVID-19 pandemic |
Graf-Vlachy, L, Sun, et al |
European Journal of Psychotraumatology |
Mental Health |
|
This study reports early evidence of managers’ mental health and its predictors during the Coronavirus disease 2019
(COVID-19) pandemic in May 2020. In a sample of 646 managers from 49 countries, 5.3% of managers reached the cut-off levels for disorders in distress, 7.3% experienced anxiety, and 10.7% had depression. Age, relative income, and work status each predicted
at least one of the conditions. |
|
Gras-Valentí, P, Chico-Sánchez, et al |
Enfermedades infecciosas y microbiologia clinica |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé Immunology
| Immunologie |
Estimate of IgG antibody prevalence against SARS-CoV-2 in healthcare personnel (HCP) of a healthcare department (HD)
in Spain was determined. . The global prevalence of IgG antibodies against SARS-CoV-2 was 6.6% (95% CI: 5.8-7.3). There were statistically significant differences depending on the occupation, from 8.7% (95% CI: 6.9-10.6) on medics down to 3.2% (95% CI: 1.0-8.0)
on personnel not associated with health care. The other characteristics did not associate significantly to antibody presence against SARS-CoV-2. |
|
|
Unmet clinical needs for COVID-19 tests in UK health and social care settings |
Graziadio, S, Urwin, et al |
PLoS One |
Healthcare Response | Réponse des soins de santé |
There is an urgent requirement to identify which clinical settings are in most need of COVID-19 tests and the priority
role(s) for tests in these settings to accelerate the development of tests fit for purpose in health and social care across the UK. 447 responses were received. Hospitals and care homes were recognized as the settings with the greatest unmet clinical need
for COVID-19 diagnostics, despite reporting more access to laboratory molecular testing than other settings. Hospital staff identified a need for diagnostic tests for symptomatic workers and patients. In contrast, care home staff expressed an urgency for screening
at the front door to protect high-risk residents and limit transmission. Rapid tests for staff were regarded as an area of need across general practice and dental settings alongside tests to limit antibiotics use. |
|
Immunological assessment of pediatric multisystem inflammatory syndrome related to COVID-19 |
Grazioli, S, Tavaglione, et al |
J Pediatric Infect Dis Soc |
Clinical data| Données cliniques Immunology | Immunologie |
We report a series of four pediatric patients admitted to Geneva University Hospitals with persistent fever and laboratory
evidence of inflammation meeting published definition of multisystem inflammatory syndrome in children (MIS-C) related to COVID-19, to whom an extensive virological and immunological workup was performed. Our findings suggest that MIS-C related to COVID-19
is caused by a post-infectious inflammatory syndrome associated with elevation in all cytokines, and markers of recent T-cell activation (sIL-2R) occurring despite a strong and specific humoral response to SARS-CoV2. |
|
Massive X-ray screening reveals two allosteric drug
binding sites of SARS-CoV-2 main protease |
Guenther, Sebastian, Reinke, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In a search for a drug against COVID-19, we have performed a massive X-ray crystallographic screen of repurposing drug
libraries containing 5953 individual compounds against the SARS-CoV-2 main protease (Mpro), which is a potent drug target as it is essential for the virus replication. From the three-dimensional protein structures, we identified 37 compounds binding to Mpro.
In subsequent cell-based viral reduction assays, one peptidomimetic and five non-peptidic compounds showed antiviral activity at non-toxic concentrations. Interestingly, two compounds bind outside the active site to the native dimer interface in close proximity
to the S1 binding pocket. |
|
Guo, L, Bi, et al |
Cell Res |
Coronavirology| Coronavirologie |
Engineered trimeric ACE2 proteins based on wild-type ACE2 and showed that T-ACE2 could bind spike protein with extremely
high affinity to potently inhibit all tested pseudotyped viruses including SARS-CoV-2, SARS-CoV, eight naturally occurring SARS-CoV-2 mutants, two SARSr-CoVs as well as authentic SARS-CoV-2. |
|
|
Gupta, R, Singhal, et al |
Journal of Clinical Orthopaedics and Trauma |
Healthcare Response | Réponse des soins de santé |
This study was done to see the effect of COVID-19 on management of open fractures. Despite the decrease in total trauma
cases, a delay in presentation to the emergency room/administration of first dose of antibiotic and increase in temporary fixation in form of external fixator was observed. |
|
|
Hafeez, Muhammad Mansoor, Azhar, et al |
medRxiv |
Mental Health |
|
An AUDIO-VISUAL TRIAGE (AVT) system was introduced at at Bahria Town International Hospital, Lahore, to enhance confidence
as well as increase the safety of frontline healthcare professionals. AVT system for COVID-19 screening found to be more safe and less stressful than visual triage. |
|
|
Hanif, W, Ali, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study determines the clinical features and biochemical markers in COVID-19 patients at a tertiary care hospital,
in Multan, Pakistan. Thirteen (20.6%) patients presented with fever, 14 (22.2%) had productive cough and only 3 (4.8%) patients were aware of known history of contact. Median (IQR) value of serum ferritin, LDH, albumin, AST, CRP and urea were 176.5 (252) ng/ml,
284 (96) IU/L, 42 (7) g/L, 28 (22) U/L, 3.9 (11) mg/L and 4.25 (1.6) mmol/L, respectively. |
|
|
Hu, Gang, Liu, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We retrospect benign clinical and epidemiological outcomes-associated factors from a solved epidemic in a low epidemic
area. All 98 laboratory-confirmed COVID-19 patients in a local epidemic (Zhuhai, China) from January 17, 2020 to March 10, 2020 were enrolled. Data were updated until all patients having final outcomes. Younger age, lack of aging-related diseases and early
hospitalization of all patients to conduct antiviral treatment and prevention of secondary epidemic were the important benign clinical and epidemiological outcomes-associated factors of COVID-19. In combating COVID-19, the active intervention strategies are
crucial in low epidemic areas and the continuous monitoring of lymphocytes may be useful to sort patients reasonably in high epidemic areas. |
|
|
Hu, M, Roberts, et al |
Sustainable Cities and Society |
Epidemiology| Épidémiologie |
This study assessed the relationship between several social determinants of health, including housing quality, living
condition, travel pattern, race/ethnicity, household income, and COVID-19 outcomes in Washington, D.C (DC). The results demonstrated that housing quality, living condition, race and occupation were strongly correlated with COVID-19 death count. The potential
hot spots within DC were also identified based the regression model using currently available data. It can be concluded that based on the current available COVID-19 information, the identified combined built and social environment variables are the strongest
and most significant predicators of COVID-19 death counts. And among those variables, crowding ratio has most significant influence, followed by work commute time and Black American Ratio. |
|
|
Predictive value of laboratory tests on severity of newly hospitalized
patients with COVID-19 |
Huang, Z, Xu, et al |
Chinese Journal of Laboratory Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We explore the value of testing indicators for predicting the severity of illness when patients with new coronavirus
pneumonia (COVID-19) are admitted to the hospital. Indicators such as WBC, LYM, ESR, LDH, etc. at admission can help determine the severity of COVID-19. Although the level of IL-6 has increased, it may be meaningless to determine the severity of the disease. |
|
Huen, DavidS |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this framework, mortality amongst those infected for the first time is mostly amongst the old but survivors acquire
fatal infection immunity (FII). Subjects with FII can subsequently be infected and infect others without suffering significant mortality. A multi-compartment ODE model was constructed to explore the implications of this proposal on the evolution of a zoonosis
sharing properties of both SARS-CoV-2 and endemic coronaviruses. The results show that mortality has two components, the first incurred during transition to endemicity and the other is exacted on a continuing basis. The relative contribution of each depends
on the longevity of the FII state. In particular, a one-time vaccination of the older subpopulation is sufficient to reduce total mortality if FII is long-lived. The effect of a regular vaccination was also examined when FII was shorter lived. Herd immunity
was not achieved. The validity of this proposal with regard to Covid-19 depends on whether reinfection with SARS-CoV-2 behaves in the manner expected of FII. If it does, then certain considerations apply to how Covid-19 is to be managed and how vaccine choice
could influence that. |
|
|
Husain, Taha, Chowdhury, et al |
bioRxiv |
Mental Health |
|
This study identified the level of Mental Health Status of Adolescents During the COVID-19 Pandemic among the Bangladeshi
Graduate Student. The mean score of mental health status was 2.08 based on four points scale. They felt problem in decision making (3.04), in doing the things well (2.92), in enjoying normal day to day life (2.88), in playing a useful part in life (2.85),
in doing their task (2.75), living in perfectly well and in good health (2.70). The respondents also developed a suicidal tendency (2.55), felt nervous in strung-up (2.24), took longer time to do things (2.14), felt tightness and pressure in head (2.12), and
found themselves pressurized by various stuff (2.05). This study also found a significant positive relationship between mental health status and age, living with parents, and parents’ attitude. Finally, this study revealed that the respondents managed their
stress by chatting with their friends, parents and siblings, and by sleeping. |
|
|
Idowu, Oluwaseun Mercy, Adaramola, et al |
medRxiv |
Mental Health |
|
This study assessed and compared the psychological distress of COVID-19 among male and female medical students in medical
schools in South-Western Nigeria. Females were almost twice at risk of psychological distress during the COVID-19 pandemic than males (OR=1.534, 95% p=0.003). |
|
|
Igbinovia, MO, Okuonghae, et al |
Reference Services Review |
Public Health response| Interventions de santé publique |
This study examined the effect of Information Literacy Competency (ILC) in curtailing the spread of fake news among
Library and Information Science (LIS) undergraduates in Nigeria. The study revealed that the students had high level of ILC (x ¯ = 3.42), and there was low prevalence level of COVID-19 pandemic fake news (x ¯ = 2.35) among them. The major causes of COVID-19
fake news were too much information in circulation concerning COVID-19 (x ¯ = 3.44) and the resultant inability to discern or spot fake news from verified and authentic news (x ¯ = 3.28). The study also revealed that ILC had a significant effect in curtailing
the spread of COVID-19 fake news with a grand mean of 3.28 against the criterion mean of 2.5. It is implied that LIS undergraduates are educationally position to acquire ILC which is crucial to their identification of fake news and helps to curtail its spread. |
|
|
Covid-19: Adaptation of a model to predict healthcare resource needs in valle del
Cauca, Colombia |
Iragorri, N, Gómez-Restrepo, et al |
Colombia Medica |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
This study adapted an existing model to the local context to forecast COVID-19 incidence and hospital resource use
assuming different scenarios in valle de l Cauca: (1) the implementation of quarantine from September 1st to October 15th (average daily growth rate of 2%); (2-3) partial restrictions (at 4% and 8% growth rates); and (4) no restrictions, assuming a 10% growth
rate. According to different scenarios, the estimated demand for reverse transcription-polymerase chain reaction tests ranged from 202,000 to 1,610,600 between September 1st and October 15th. The model predicted depletion of hospital and ICU beds by September
20th if all restrictions were to be lifted and the infection growth rate increased to 10%. Slowly lifting social distancing restrictions and reopening the economy is not expected to result in full resource depletion by October if the daily growth rate is maintained
below 8%. Increasing the number of available beds provides a safeguard against slightly higher infection rates. |
|
Prevalence of Coronavirus Antibody Among First Responders in Lubbock, Texas |
Iwuji, K, Islam, et al |
Journal of Primary Care and Community Health |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé Immunology
| Immunologie |
Our objective was to determine the prevalence of positive immunoglobulin G antibody specific to COVID-19 among first
responders in Lubbock, Texas. The prevalence of IgG specific antibodies to COVID-19 was 0.73%, five of the 683 participants tested positive. Four of those who tested positive had no known prior SARS-CoV-2 infection or exposure without adequate PPE. |
|
Jonker, PKC, van der Plas, et al |
Surgery (United States) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This Dutch, multicenter, matched-cohort clinical study investigates whether perioperative SARS-CoV-2 infections increase
mortality, pulmonary complications, and thromboembolic events. Patients diagnosed with perioperative SARS-CoV-2 infection were found to have an increased risk of 30-day mortality, pulmonary complications, and thromboembolic events. |
|
|
Jungreis, Irwin, Kellis, et al |
medRxiv |
Therapeutics| Thérapeutique RCT |
A randomized controlled trial of calcifediol (25-hydroxyvitamin D3) as a treatment for hospitalized COVID-19 patients
in Córdoba, Spain, found that the treatment was associated with reduced ICU admissions with very large effect size and high statistical significance. This study reanalyzed the results using rigorous and well established statistical techniques and confirmed
the findings. Recommends the consideration of the broad adoption of calcifediol treatment for vitamin-D-deficient hospitalized COVID-19 patients. |
|
|
Kahlert, ChristianR, Persi, et al |
medRxiv |
Epidemiology| Épidémiologie Immunology | Immunologie |
This study assessed seroprevalence and identified risk factors for SARS-CoV-2 seropositivity in healthcare workers
(HCW). Among the 4664 included HCW from 23 healthcare facilities, 139 (3%) were seropositive. Non-occupational exposures independently associated with seropositivity were contact with a COVID-19 positive household (adjusted OR=54, 95%-CI: 31-97) and stay in
a COVID 19 hotspot (aOR=2.2, 95%-CI: 1.1-3.9). Blood group 0 vs. non-0 (aOR=0.4, 95%-CI: 0.3-0.7), active smoking (aOR=0.5, 95%-CI: 0.3-0.9) and living with children <12 years (aOR=0.3, 95%-CI: 0.2-0.6) were associated with decreased risk. Occupational risk
factors were close contact to COVID-19 patients (aOR=2.8, 95%-CI: 1.5-5.5), exposure to COVID-19 positive co-workers (aOR=2.0, 95%-CI: 1.2-3.1), poor knowledge of standard hygiene precautions (aOR=2.0, 95%-CI: 1.3-3.2), and frequent visits to the hospital
canteen (aOR=1.9, 95%-CI: 1.2-3.1). |
|
|
Kanu, FA, Smith, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
State-mandated stay-at-home orders and public mask mandates coupled with case investigations with contact tracing contributed
to an 82% reduction in COVID-19 incidence, 88% reduction in hospitalizations, and 100% reduction in mortality in Delaware during late April–June. The combination of state-mandated community mitigation efforts and routine public health interventions can reduce
the occurrence of new COVID-19 cases, hospitalizations, and deaths. |
|
|
Perspectives on Telephone and Video Communication in the ICU during COVID-19 |
Kennedy, NR, Steinberg, et al |
Ann Am Thorac Soc |
Healthcare Response | Réponse des soins de santé |
To explore experiences, perspectives and attitudes of qualitative interviewing study with an intentional sample of
21 family members and 14 treating clinicians about phone and video interactions during COVID-19 hospital visitor restrictions. Respondents viewed phone and video communication as somewhat effective but inferior to in-person communication. Telehealth communication
between families and clinicians of ICU patients appears a somewhat effective alternative when in-person communication is not possible. Use of communication strategies specific to phone and video can improve clinician and family experiences with telehealth. |
|
Quantitative measurement of IgG to SARS-CoV-2 proteins
using ImmunoCAP |
Keshavarz, Behnam, Wiencek, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The objective of this study was develop a quantitative assay for IgG to SARS-CoV-2 proteins that could readily be implemented
in clinical and research laboratories. |
|
Khoo, B, Tan, et al |
J Clin Endocrinol Metab |
Clinical data| Données cliniques |
Detail the acute effects of COVID-19 on thyroid function and determine if these effects persisted upon recovery from
COVID-19. Most patients (86·6%) presenting with COVID-19 were euthyroid, with none presenting with overt thyrotoxicosis. Patients with COVID-19 had a lower admission TSH and FT4 compared to those without COVID-19. In the COVID-19 patients with matching baseline
thyroid function tests from 2019 (n=185 for TSH and 104 for FT4), both TSH and FT4 were reduced at admission compared to baseline. In a complete cases analysis of COVID-19 patients with TSH measurements at follow-up, admission and baseline (n=55), TSH was
seen to recover to baseline at follow-up. |
|
|
Experience of percutaneous tracheostomy in critically ill COVID-19 patients |
Kim, EJ, Yoo, et al |
Acute Crit Care |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
Report clinical experience with percutaneous tracheostomy and its safety in a real medical setting. Tracheostomy is
an essential procedure in critically ill COVID-19 patients, but it os an aerosol-generating technique and thus carries the risk of infection transmission. |
|
The forgotten numbers: A closer look at COVID-19 non-fatal valuations |
Kniesner, TJ, Sullivan, et al |
Journal of Risk and Uncertainty |
Epidemiology| Épidémiologie |
Using standard assumptions provided by the CDC, authors estimate that as of July 27, 2020, the actual number of cumulative
COVID-19 cases in the U.S. is about 47 million with almost 1 million involving hospitalizations. The adjustments show current overall non-fatal valuations ranging from about $1.5 trillion to about $9.6 trillion. |
|
Knowles, M, Aref-Adib, et al |
BJPsych Open |
Healthcare Response | Réponse des soins de santé |
Describe the steps taken by one mental health hospital to establish a COVID-19 isolation ward for adult psychiatric
in-patients and (b) how staff addressed the challenges that emerged over the period March to June 2020 |
|
|
Kohler, Julianna, Kostka, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This cohort study examined people living with HIV (PLHIV) who may have greater risk of contracting or developing severe
COVID-19 due to the underlying HIV infection or higher prevalence of comorbidities. Four data sources had a population of HIV/COVID-19 coinfected patients ranging from 288 to 4606 lives. PLHIV diagnosed with COVID-19 were younger than HIV-negative patients
diagnosed with COVID-19. PLHIV diagnosed with COVID-19 diagnosis had similar comorbidities as HIV-negative COVID-19 patients with higher prevalence of those comorbidities and history of severe disease. Treatment regimens were similar between PLHIV diagnosed
with COVID-19 or PLHIV requiring intensive services. |
|
|
A functional genomics approach to understand host
genetic regulation of COVID-19 severity |
Kuijpers, Yunus, Chu, et al |
medRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
This study employed the detailed clinical, immunological and multi-omics data of the Human Functional Genomics Projects
(HFGP) to explore the physiological significance of the host genetic variants that influence susceptibility to severe COVID-19. This investigation identified several major patterns: i. a large impact of genetically determined innate immune responses in COVID-19,
with increased susceptibility for severe disease in individuals with defective monocyte-derived cytokine production; ii. genetic susceptibility related to ABO blood groups is probably mediated through the von Willebrand factor (VWF) and endothelial dysfunction;
and iii. the increased susceptibility for severe COVID-19 in men is at least partially mediated by chromosome X-mediated genetic variation. These insights allow a physiological understanding of genetic susceptibility to severe COVID-19, and indicate pathways
that could be targeted for prevention and therapy. |
|
Reprofiling of approved drugs against SARS-CoV-2 main protease: an in-silico
study |
Kumar, P, Bhardwaj, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Employed drug repurposing approach to identify potential inhibitors of SARS-CoV-2 in a shorter time span. Screening
of approved drugs through docking reveals Hyaluronic acid and Acarbose among the top hits which are showing strong interactions with catalytic site residues of M(pro). We have also performed docking of drugs Lopinavir, Ribavirin, and Azithromycin on SARS-CoV-2
M(pro). Further, binding of these compounds (Hyaluronic acid, Acarbose, and Lopinavir) is validated by extensive molecular dynamics simulation of 500 ns where these drugs show stable binding with M(pro). We believe that the high-affinity binding of these compounds
will help in designing novel strategies for structure-based drug discovery against SARS-CoV-2. |
|
Kumari, Kamlesh, Kumar, et al |
Research Square prepub |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In the present work, kuwanons are proposed to be promising candidates against the main protease of SARS-CoV-2, ACE-2
and falcipan-2. The interaction between the different kuwanons with different receptors has been studied using the binding energy. Kuwanon M was found to best inhibitor against the main protease of SARS-CoV-2 and ACE-2. Further, the drug-likeness properties
of all the 16 kuwanons were studied. Kuwanon-M found to be best inhibitor against the ACE-2 and main protease of SARS-CoV-2 with binding energy of -165.349 and -149.952 kcal/mol respectively while kuwanon-G found out to promising against the falcipan-2 with
a binding energy of -149.573 kcal/mol. |
|
|
A practical PPE decontamination method using warm air
and ambient humidity |
Kwiek, JesseJ, Pickett, et al |
bioRxiv |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
This study proposes a low temperature, ambient humidity decontamination method (WASP-D) based on the thirty minute
or less half-life of Sars-CoV-2 (and other common pathogens) at temperatures above 45C, combined with the observation that most PPE are designed to be safely transported and stored at temperatures below 50C. Decontamination at 12 hours, 46C (115F) and ambient
humidity should consistently reduce SARS-CoV-2 viral load by a factor of 10-6, without negatively affecting PPE materials or performance. |
|
Endomyocardial Biopsy in a Pediatric Patient With Cardiac Manifestations
of COVID-19 |
Laurence, C, Haini, et al |
Circ Heart Fail |
Clinical data| Données cliniques |
Present a case of an 11 year old girl exhibiting hyperinflammatory shock resulting from COVID-19 infection. |
|
Lavery, AM, Preston, et al |
MMWR Morb Mortal Wkly Rep |
Long-Term Sequelae |
|
Assessed patterns of hospital discharge, readmission, and demographic and clinical characteristics associated with
hospital readmission after a patient's initial COVID-19 hospitalization (index hospitalization). Among 126,137 unique patients with an index COVID-19 admission during March-July 2020, 15% died during the index hospitalization. Among the 106,543 (85%) surviving
patients, 9% (9,504) were readmitted to the same hospital within 2 months of discharge through August 2020. More than a single readmission occurred among 1.6% of patients discharged after the index hospitalization. Readmissions occurred more often among patients
discharged to a skilled nursing facility (SNF) (15%) or those needing home health care (12%) than among patients discharged to home or self-care (7%). The odds of hospital readmission increased with age among persons aged ≥65 years, presence of certain chronic
conditions, hospitalization within the 3 months preceding the index hospitalization, and if discharge from the index hospitalization was to a SNF or to home with health care assistance. |
|
|
Law, WY, Asaruddin, et al |
BMC Res Notes |
Therapeutics| Thérapeutique |
Aim of this study was to use Ligand-based pharmacophore modelling approach for four established antiviral drugs, namely
remdesivir, lopinavir, ritonavir and hydroxychloroquine for COVID-19 inhibitors as training sets. |
|
|
Lee Dr, Edison, Krajewski Dr, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To investigate the incidence of thromboembolic events, specifically pulmonary embolism (PE), deep vein thrombosis (DVT),
and cerebrovascular accidents (CVA), in patients tested positive for COVID-19 through RT-PCR in a regional healthcare system in Connecticut. 192 patients underwent 245 vascular imaging studies including chest CTA (86), venous duplex ultrasound (134), and
CTA head and neck (25). Among those who underwent imaging, 49 (26%) demonstrated acute thromboembolic events which included 13/86 (15%) with PE, 34/134 (25%) with DVT, and 6/25 (24%) with CVA. One patient had positive results on all 3 examinations and 2 patients
had positive results on both chest CTA and venous duplex US. Males were more likely to have a thromboembolic event than females (33/103 (34%) vs. 14/89 (16%), p=0.009). No significant difference was observed with respect to age, cardiopulmonary comorbidities,
malignancy history, diabetes, or dialysis. |
|
|
Leeb, RT, Bitsko, et al |
MMWR Morb Mortal Wkly Rep |
Mental Health |
|
During March 29-April 25, 2020, when widespread shelter-in-place orders were in effect, ED visits for persons of all
ages declined 42% compared with the same period in 2019; during this time, ED visits for injury and non-COVID-19-related diagnoses decreased, while ED visits for psychosocial factors increased. To assess changes in mental health-related ED visits among U.S.
children aged <18 years, data from CDC's National Syndromic Surveillance Program (NSSP) from January 1 through October 17, 2020, were compared with those collected during the same period in 2019. During weeks 1-11 (January 1-March 15, 2020), the average reported
number of children's mental health-related ED visits overall was higher in 2020 than in 2019, whereas the proportion of children's mental health-related visits was similar. Beginning in week 12 (March 16) the number of mental health-related ED visits among
children decreased 43% concurrent with the widespread implementation of COVID-19 mitigation measures; simultaneously, the proportion of mental health-related ED visits increased sharply beginning in mid-March 2020 (week 12) and continued into October (week
42) with increases of 24% among children aged 5-11 years and 31% among adolescents aged 12-17 years, compared with the same period in 2019. The increased proportion of children's mental health-related ED visits during March-October 2020 might be artefactually
inflated as a consequence of the substantial decrease in overall ED visits during the same period and variation in the number of EDs reporting to NSSP. However, these findings provide initial insight into children's mental health in the context of the COVID-19
pandemic and highlight the importance of continued monitoring of children's mental health throughout the pandemic |
|
|
Lenze, EJ, Mattar, et al |
JAMA |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
Determine whether fluvoxamine, given during mild COVID-19 illness, prevents clinical deterioration and decreases the
severity of disease. Of 152 patients who were randomized (mean SD] age, 46 13] years; 109 72%] women), 115 (76%) completed the trial. Clinical deterioration occurred in 0 of 80 patients in the fluvoxamine group and in 6 of 72 patients in the placebo group
(absolute difference, 8.7% 95% CI, 1.8%-16.4%] from survival analysis; log-rank P = .009). The fluvoxamine group had 1 serious adverse event and 11 other adverse events, whereas the placebo group had 6 serious adverse events and 12 other adverse events. |
|
|
Human coronavirus dependency on host heat shock protein 90 reveals an antiviral
target |
Li, C, Chu, et al |
Emerg Microbes Infect |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We inspected the role of heat shock protein (Hsp90) for coronavirus propagation. First, an Hsp90 inhibitor, 17-AAG,
significantly suppressed MERS-CoV propagation in cell lines and physiological-relevant human intestinal organoids. Second, siRNA depletion of Hsp90β, but not Hsp90α, significantly restricted MERS-CoV replication and abolished virus spread. Third, Hsp90β interaction
with MERS-CoV nucleoprotein (NP) was revealed in a co-immunoprecipitation assay. Hsp90β is required to maintain NP stability. Fourth, 17-AAG substantially inhibited the propagation of SARS-CoV and SARS-CoV-2. Collectively, Hsp90 is a host dependency factor
for human coronavirus MERS-CoV, SARS-CoV and SARS-COV-2. Hsp90 inhibitors can be repurposed as a potent and broad-spectrum antiviral against human coronaviruses. |
|
Li, D |
Iranian Journal of Public Health |
Mental Health |
|
This study aims to clarify the influence mechanisms of psychological capital and coping style on social anxiety during
the COVID-19 pandemic outbreak. Youth’s psychological capital is closely associated with coping style and social anxiety. |
|
|
Li, X, Liu, et al |
International immunopharmacology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study aimed to investigate the efficiency and safety of Tα1 treatment and provide a basis for practically identifying
gender differences characteristics and features of COVID-19. In this retrospective analysis, we found that COVID-19-infected males reported more symptoms than COVID-19-infected females. A high degree of gender differences-related variability was observed in
CRP and PCT levels and the cell counts of many lymphocyte subpopulations in the COVID-19 patients after Tα1 intervention. Levels of CRP and IL-6 were higher in Tα1-treated male group than Tα1-treated female group, while the level of PCT was significantly lower
in Tα1-treated male group. Gender differences may be a factor in sustaining COVID-19 immunity responded to Tα1, male and female show statistically significant differences in relevance to cytokine production associated with the development of a more significant
number of symptoms. |
|
|
Li, Y, Yang, et al |
World Journal of Clinical Cases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aim to determine the predictive value of Serum cystatin C (sCys C) for the prognosis of patients with COVID-19.
Results show that sCys C is an independent risk factor for death in patients with COVID-19. Patients with a sCys C level of 0.80 mg/L or greater are at a high risk of death. |
|
|
Lilleri, D, Zavaglio, et al |
PLoS One |
Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions
de sant&eacute; publique |
Analyzed the evolution of the first wave of the SARS-CoV-2 epidemic throughout Italy and factors associated to the
different way it spread in the Italian Regions, starting from the day that the first indigenous cases were detected through day 81 (6 days after the end of the strict lockdown). analyzed the impact of local and interventional variables on the epidemic curve
in each Region. The number of cases correlated inversely with the distance from the area in which first cases were detected and directly also with the gross domestic product pro capite (as a marker of industrial activity) of the Region. Moreover, an earlier
start of the lockdown (i.e. in the presence of a lower number of cases) and wider testing were associated with a lower final number of total cases. In conclusion, this analysis shows that population-wide testing and early lockdown enforcement appear effective
in limiting the spreading of the SARS-CoV-2 epidemic. |
|
|
Linnemayr, S, Barreras, et al |
J Acquir Immune Defic Syndr |
Mental Health |
|
We provide much-needed, longitudinal information on how COVID-19 is impacting the mental and sexual health of Latinx
SMM and TGW across Los Angeles County. We find a significant decline across mental health outcomes that seem to be more pronounced among Latinx TGW. We also find a decrease in sexual behaviors such as condomless sex. |
|
|
Lins, PRG, de Albuquerque, et al |
Trials |
RCT |
Trial Protocol |
|
|
Liotti, FM, Menchinelli, et al |
JAMA Intern Med |
Clinical data| Données cliniques |
Investigated RT-PCR retested positive nasal/oropharyngeal swab (NOS) samples from recovered patients with COVID-19
with prior negative results for the presence of replicative SARS-CoV-2 RNA. 32 of 176 nasal/oropharyngeal swab (NOS) samples (18.2%) tested positive for total SARS-CoV-2 RNA, with viral loads ranging from 1.6 × 101 to 1.3 × 104 SARS-CoV-2 RNA copies per mL.
One of the 32 samples (3.1%) had replicative SARS-CoV-2 RNA. Samples from the 32 patients at the time of COVID-19 diagnosis were also tested and, expectedly, had replicative SARS-CoV-2 RNA. All but 1 of 32 patients had a positive serology result against SARS-CoV-2,
as well as 139 of remaining 144 patients, at COVID-19 follow-up. The patient who tested serologically negative was not the one with a positive test result for replicative SARS-CoV-2 RNA. The mean (SD) time from COVID-19 diagnosis to follow-up was 48.6 (13.1)
days in 32 patients and 57.7 (16.9) days in 144 patients. Only 1 of 32 patients retesting positive had replicating virus in the NOS sample, suggesting either recurrent infection or reinfection. The patient retested positive 16 days after COVID-19 recovery
and was symptomatic. In the 31 remaining patients (who were asymptomatic), their positive result likely represented either recurrent or resolving infection and were unlikely to be infectious. |
|
|
Google Searches for Taste and Smell Loss Anticipate
Covid-19 Epidemiology |
Lippi, Giuseppe, Henry, et al |
medRxiv |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
We investigated whether Google searches volume for two disease-specific symptoms, taste and smell, could be associated
with disease epidemiology in United States. The correlation coefficient of summing Google Trends scores for the two symptoms and the number of new weekly SARS-CoV-2 infections two weeks later was 0.82 (95% CI, 0.68-0.90; p<0.001), and was associated 0.89 diagnostic
accuracy. |
|
Liu, L, Xie, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
This study aimed at probing how the media would affect the public’s preventive behavior and excessive preventive intention
accordingly. The results showed that mass media exposure had a significant positive impact on subjective norms; moreover, mass media exposure could significantly enhance preventive behavior through subjective norms, and social networking services involvement
had a significant positive impact on negative emotions; meanwhile, social networking services involvement promoted excessive preventive intention through negative emotions. |
|
|
A preliminary experimentation for large scale epidemic forecasting simulations |
Lombardo, G, Poggi, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper presents an actor software library, called ActoDeS, for the development of concurrent and distributed systems,
and shows how it can be a suitable mean for building flexible and scalable epidemic forecasting simulations. The paper presents the first results of the experimentation of ActoDeS for defining a COVID-19 epidemic diffusion model and for supporting the simulation
in large populations. |
|
The psychological states of people after Wuhan eased the lockdown |
Lu, P, Li, et al |
PLoS One |
Mental Health |
|
Assessed people's mental health and the changes after Wuhan eased the lockdown. A cross-sectional online study among
citizens in Wuhan was conducted. Among 1417 participants, 387(27.0%) were frontline healthcare workers and 1035(73.0%) were residents from the general public. Their COVID-19 psychological status was evaluated using Patient Health Questionnaire-9(PHQ-9), Generalized
Anxiety Disorder 7-item (GAD-7), and the PTSD Checklist-Civilian Version (PCL-C). Results show that 16.1%,22.3% and 17.2% healthcare workers and 21.2%, 16.7% and 17.2% general public had symptoms of depression, anxiety and PTSD ranging from moderate to severe.
Anxiety levels were not significantly different between healthcare workers and the general public. The decreased income and the frequent social media exposure are the risk factors for general public. Compared to the early COVID-19 epidemic period, the proportion
of anxiety and depression among both the general public and health workers decreased after Wuhan eased the lockdown. |
|
Lu, WH, Ko, et al |
International Journal of Environmental Research and Public Health |
Mental Health |
|
This study explored the associations of individual factors (demographic characteristics, self-confidence in responding
to the coronavirus disease 2019 (COVID-19), and self-rated physical and mental health) and environmental factors (perceived confidence in COVID-19 management by the regional government and adequacy of resources and support available to address the COVID-19
pandemic) with worry toward COVID-19 and general anxiety among people in Taiwan. |
|
|
Motivating social distancing during the COVID-19 pandemic: An online experiment |
Lunn, PD, Timmons, et al |
Social Science and Medicine |
Public Health response| Interventions de santé publique |
Authors aimed to test two novel public health messages against a control message. Messages that invoke thoughts of
infecting vulnerable people or large numbers of people can motivate social distancing and, hence, help to limit the spread of COVID-19. |
|
Mahale, P, Rothfuss, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Transmission |
During August 7-September 14, 2020, the Maine Center for Disease Control and Prevention (MeCDC) investigated a COVID-19
outbreak linked to a wedding reception attended by 55 persons in a rural Maine town. In addition to the community outbreak, secondary and tertiary transmission led to outbreaks at a long-term care facility 100 miles away and at a correctional facility approximately
200 miles away. Overall, 177 COVID-19 cases were epidemiologically linked to the event, including seven hospitalizations and seven deaths (four in hospitalized persons). Investigation revealed noncompliance with CDC's recommended mitigation measures. |
|
|
Mahendradhata, Yodi, Lestari, et al |
medRxiv |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
Medical and health academics from ten universities across Indonesia achieved consensus for 5 top priorities for improving
government’s response to COVID-19: (1) The authorities communicate clearly and consistently about COVID-19 and provide public health grounds for their decisions; (2) Everyone can get a free, reliable COVID-19 test quickly and receive the results promptly;
(3) Contact tracing is implemented for positive cases; (4) Public health experts, government officials, and academic researchers agree on COVID-19 nomenclature and clearly explain the reasons for public health measures; and (5) Government communications target
the entire diverse population. |
|
|
CoSIR: Managing an Epidemic via Optimal Adaptive
Control of Transmission Policy |
Maheshwari, Harsh, Shetty, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique |
This paper considers the problem of determining the optimal policy for transmission control assuming SIR dynamics,
which is the most widely used epidemiological paradigm. First demonstrate that the SIR model with infectious patients and susceptible contacts (i.e., product of transmission rate and susceptible population) interpreted as predators and prey respectively reduces
to a Lotka-Volterra (LV) predator-prey model. The modified SIR system (LVSIR) has a stable equilibrium point, an energy conservation property, and exhibits bounded cyclic behaviour similar to an LV system. This mapping permits a theoretical analysis of the
control problem supporting some of the recent simulation-based studies that point to the benefits of periodic interventions. Also use a control-Lyapunov approach to design adaptive control policies (CoSIR) to nudge the SIR model to the desired equilibrium
that permits ready extensions to richer compartmental models. |
|
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain
in lipid bilayers |
Mandala, VS, McKay, et al |
Nat Struct Mol Biol |
Coronavirology| Coronavirologie |
An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a homopentameric cation channel that is
important for virus pathogenicity. The study reports a 2.1-Å structure and the drug-binding site of E’s transmembrane domain (ETM), determined using solid-state NMR spectroscopy. |
|
Clinical Case: SARS-CoV-2 Reactivation after a Heavy Workout |
Marchev, S, Hadzhimineva, et al |
Acta Medica Bulgarica |
Clinical data| Données cliniques |
We present a clinical case of a patient with reactivation of SARS-CoV-2 infection after strenuous exercise in the gym.
Reactivation of the virus was confirmed after detecting SARS-CoV-2 in a nasopharyngeal swab sample using real-time polymerase chain reaction (PCR). The clinical symptoms of the patient - fever and shortness of breath, as well as the presence of IgM antibodies
further confirmed the diagnosis. The subjective complaints of persistent shortness of breath for more than a few weeks were noted. |
|
Public Health response to an outbreak of SARS-CoV-2
infection in a Barcelona prison |
Marco, Andres, Gallego, et al |
medRxiv |
Epidemiology| Épidémiologie |
An outbreak of SARS-CoV2 infection in a Barcelona prison was studied after seven cases appeared in nine days. Outbreaks
pose a huge risk, must be detected early, are difficult to manage, and require optimal coordination between health and prison authorities. |
|
Marshall, Fiona, Gordon, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
This study examined the complex interdependencies of support as staff responded to COVID-19. The aim was to inform
more effective responses to the ongoing pandemic, and to improve understanding of how to work with care home staff and organisations after the pandemic has passed. Three key groups of interdependencies were identified: care processes and practice; resources;
and governance. Care home staff had to deliver care in innovative ways, making high stakes decisions in circumstances defined by: fluid ties to organisations outside the care home; multiple, sometimes conflicting, sources of expertise and information; and
a sense of deprioritisation by authorities. Organisational responses to the pandemic by central government resulted in resource constraints and additional work, and sometimes impaired the ability of staff and managers to make decisions. Local communities,
including businesses, third-sector organisations and individuals, were key in helping care homes overcome challenges. |
|
|
Emergency surgery in the time of Coronavirus: the pandemic effect |
Martellucci, J, Damigella, et al |
Minerva Chir |
Healthcare Response | Réponse des soins de santé |
Aim of the present study was to evaluate the impact of the pandemic period in the need of surgical emergencies. The
COVID pandemic has caused major changes in daily clinical practice, especially in areas such as Emergency. This has led to a temporary reduction and changes in the flow of patients to the emergency room, with implications also for emergency surgical activities. |
|
Matvienko-Sikar, K, Pope, et al |
Women and Birth |
Mental Health |
|
The aim of this work was to examine antenatal stress and stress-reduction strategies, social support, and health behaviours
between women pregnant before and during the pandemic in Ireland. Findings highlight negative impacts of the pandemic on social support, stress, and physical activity, which can have implications for maternal and child health. |
|
|
Analysis of mitigation of Covid-19 outbreaks in workplaces
and schools by hybrid telecommuting |
Mauras, Simon, Cohen-Addad, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique |
Here, we develop a simulation study to analyze Covid-19 transmission on three real-life contact networks from a workplace,
a primary school and a high school in France. The advantage of a weekly alternation over a daily alternation, despite significant, is very slight |
|
Gaps in Knowledge About COVID-19 Among US Residents Early in the Outbreak |
McCormack, LA, Squiers, et al |
Public Health Rep |
Public Health response| Interventions de santé publique |
This study aimed to assess the US public’s initial understanding about the disease and virus to inform public health
communication efforts via a cross-sectional survey. Knowledge about COVID-19 and the virus was relatively low overall at the beginning of the outbreak. Knowledge was especially low among people who had low education and income levels, were unemployed, were
Hispanic, were non-Hispanic Black, were aged 18-24 and 35-49, indicated having “other” health insurance, and had limited exposure to information about the pandemic. |
|
A retrospective cluster analysis of COVID-19 cases
by county |
Megahed, FadelM, Jones-Farmer, et al |
bioRxiv |
Epidemiology| Épidémiologie |
This study examined these three research questions: (1) How many distinct clusters of counties exhibit similar COVID-19
patterns in the time-series of daily confirmed cases?; (2) What is the geographic distribution of the counties within each cluster? and (3) Are county-level demographic, socioeconomic and political variables associated with the COVID-19 case patterns? Four
patterns were identified from the timing of the outbreaks including counties experiencing a spring, an early summer, a late summer, and a fall outbreak. Several county-level demographic, socioeconomic, and political variables showed significant associations
with the identified clusters. The timing of the outbreak is related both to the geographic location within the U.S. and several variables including age, poverty distribution, and political association. These results show that the reported pattern of cases
in the U.S. is observed through aggregation of the COVID-19 cases, suggesting that local trends may be more informative. |
|
Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection
in COPD |
Mehedi, Masfique, Osan, et al |
bioRxiv |
Clinical data| Données cliniques |
The researchers established an airway epithelium model to study SARS-CoV-2 infection in healthy and COPD lung cells.
Found that both the entry receptor ACE2 and the co-factor transmembrane protease TMPRSS2 are expressed at higher levels on nonciliated goblet cell, a novel target for SARS-CoV-2 infection. Also observed that SARS-CoV-2 infected goblet cells and induced syncytium
formation and cell sloughing. And found that SARS-CoV-2 replication was increased in the COPD airway epithelium likely due to COPD associated goblet cell hyperplasia. These results reveal goblet cells play a critical role in SARS-CoV-2 infection in the lung. |
|
Meinberger, Denise, Koch, et al |
Research Square prepub |
Clinical data| Données cliniques Immunology | Immunologie |
We aimed to gain insight into the serological immune response of SARS‑CoV‑2 patients by immunoblot analysis. We analyzed
serum immunoglobulins IgM, ‑A, and ‑G directed against SARS‑CoV‑2 proteins by immunoblot analysis from 12 infected patients. We determined IgG isotype antibodies by commercially available ELISA, and assessed clinical parameters of inflammation status, kidney,
and liver injury. We found evidence for antibody cross‑reactivity, which calls into question a reliable assessment of serum samples tested negative for anti‑SARS‑CoV‑2 antibodies by immunoassays. Nevertheless, for the detection of IgG anti‑SARS‑CoV‑2 antibodies,
our data suggest that the use of the spike glycoprotein in immunoassays should be sufficient to identify positive patients. Using a combination of the spike glycoprotein and the open reading frame 8 protein could prove to be the best for the detection of patients
positive for anti‑SARS‑CoV‑2 IgM antibodies. We found that the antibody response alone is not decisive for the course of the disease but the inflammation parameters are promising indicators. |
|
|
Metabolomic/lipidomic profiling of COVID-19 and individual
response to tocilizumab |
Meoni, Gaia, Ghini, et al |
medRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Here, plasma-EDTA samples of 30 patients compared with age- and sex-matched controls were analyzed via untargeted nuclear
magnetic resonance (NMR)-based metabolomics and lipidomics. With the same approach, the effect of tocilizumab administration was evaluated in a subset of patients. Despite the heterogeneity of the clinical symptoms, COVID-19 patients are characterized by common
plasma metabolomic and lipidomic signatures (91.7% and 87.5% accuracy, respectively, when compared to controls). Tocilizumab treatment resulted in at least partial reversion of the metabolic alterations due to SARS-CoV-2 infection. |
|
Gender,
age and comorbidities as the main prognostic factors in patients with COVID-19 pneumonia |
Mi, J, Zhong, et al |
American Journal of Translational Research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
. In the present study, we systematically explored the prognostic value of the clinical factors (gender, age and comorbidities)
in 189 COVID-19 patients from Wuhan, China. We discovered that the gender, age and comorbidities were tightly associated with the survival of COVID-19 patients via performing Kaplan-Meier curve analysis. Compared with the female patients, male patients have
a lower survival rate. Similarly, the older patients and those with more comorbidities also tended to have an unfavorable survival outcome. In addition, further stratified analysis of COVID-19 patients according to the three risk factors indicated that some
laboratory indicators including CRP, IL-6 and lymphocytes showed significant trends in gender, age and comorbidities groups. Together, these result which may provide a certain reference value for the prevention and treatment of COVID-19. |
|
Milani, Mario, Donalisio, et al |
bioRxiv |
Therapeutics| Thérapeutique |
This study developed a pipeline based on in silico docking of known drugs on SARS-CoV RNA-dependent RNA polymerase
combined with in vitro antiviral assays on both SARS-CoV-2 and the common cold human coronavirus HCoV-OC43. Results showed that certain drugs displayed activity for both viruses at a similar inhibitory concentration, while others were specific. In particular,
the antipsychotic drug lurasidone and the antiviral drug elbasvir showed promising activity in the low micromolar range against both viruses with good selective index. |
|
|
A case of postpartum thyroiditis following SARS-CoV-2 infection |
Mizuno, S, Inaba, et al |
Endocr J |
Long-Term Sequelae |
|
Postpartum thyroiditis (PPT) is characterized by mild thyrotoxicosis occurring within one year of parturition commonly
followed by transient hypothyroidism. A 29-year-old woman developed general fatigue four and a half months after parturition, and was diagnosed as having PPT: one month before, she had COVID-19. |
|
Treatment with Tocilizumab for Patients with Covid-19 Infections: A Case-series Study |
Mo, Y, Adarkwah, et al |
J Clin Pharmacol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Evaluated the safety and effectiveness of TCZ as an adjunct therapy for the treatment of severe COVID-19 infections.
This is a retrospective, observational chart review of confirmed COVID-19 patients who received TCZ, along with other COVID-19 therapies. This study included 38 patients with an average age of 63 years (IQR: 48-70). The average dose of TCZ given was 519 ±
61 mg. The median values of C-reactive protein (CRP) significantly decreased following TCZ administration (189.9 vs. 54.8 mg/L). Nineteen (73 %) of all febrile patients before the initiation of TCZ became fever free on the fourth day of TCZ treatment. Following
TCZ treatment, 11 patients developed infections due to multidrug-resistant bacteria, and elevated liver transaminases were observed in 6 patients. The preliminary findings of this study suggested TCZ appeared to ameliorate COVID-19-related cytokine storm syndrome. |
|
Mohamad, E, Tham, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
Examines the sources of information for COVID-19 used by the Malaysian public and identifies those that are associated
with building public confidence and positive perceptions toward the Malaysian government. Malaysians primarily used television and internet news portals to access information on COVID-19. The Malaysian Ministry of Health was the most preferred source of COVID-19
information; were more likely to believe that the country could win the battle against COVID-19. Those who used the World Health Organization, friends, YouTube, family, and radio as sources of information were less likely to harbor confidence and positive
belief toward combating COVID-19. |
|
|
Mohapatra, S, Nath, et al |
PLoS One |
Therapeutics| Thérapeutique |
Report the Machine Learning (ML) model based on the Naive Bayes algorithm, which has an accuracy of around 73% to predict
the drugs that could be used for the treatment of COVID-19. Our study predicts around ten FDA approved commercial drugs that can be used for repurposing. Among all, we found that 3 of the drugs fulfils the criterions well among which the antiretroviral drug
Amprenavir (DrugBank ID-DB00701) would probably be the most effective drug based on the selected criterions. |
|
|
Identifying and prioritizing potential human-infecting
viruses from their genome sequences |
Mollentze, Nardus, Babayan, et al |
bioRxiv |
Coronavirology| Coronavirologie zoonoses |
We developed machine learning algorithms that identify candidate zoonoses using evolutionary signals of host range
encoded in viral genomes. This reduces lists of hundreds of viruses with uncertain human infectivity to tractable numbers for prioritized research, generalizes to virus families excluded from model training, can distinguish high risk viruses within families
that contain a minority of zoonotic species, and could have identified the exceptional risk of SARS-CoV-2 prior to its emergence. Genome-based risk assessment allows identification of high-risk viruses immediately upon discovery, increasing both the feasibility
and likelihood of downstream virological and ecological characterization and allowing for evidence-driven virus surveillance. |
|
Monk, PhillipD, Marsden, et al |
The Lancet Respiratory Medicine |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
We assessed the efficacy and safety of inhaled nebulised interferon beta-1a (SNG001) for the treatment of patients
admitted to hospital with COVID-19. We did a randomised, double-blind, placebo-controlled, phase 2 pilot trial at nine UK sites. Between March 30 and May 30, 2020, 101 patients were randomly assigned to SNG001 (n=50) or placebo (n=51). 66 (67%) patients required
oxygen supplementation at baseline: 29 in the placebo group and 37 in the SNG001 group. Patients receiving SNG001 had greater odds of improvement on the OSCI scale (odds ratio 2·32 [95% CI 1·07–5·04]; p=0·033) on day 15 or 16 and were more likely than those
receiving placebo to recover to an OSCI score of 1 (no limitation of activities) during treatment (hazard ratio 2·19 [95% CI 1·03–4·69]; p=0·043). SNG001 was well tolerated. The most frequently reported treatment-emergent adverse event was headache (seven
[15%] patients in the SNG001 group and five [10%] in the placebo group). There were three deaths in the placebo group and none in the SNG001 group. |
|
|
Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection |
Monteil, V, Dyczynski, et al |
EMBO Mol Med |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Investigated additive effect of combination therapy using remdesivir with recombinant soluble ACE2 (high/low dose)
on Vero E6 and kidney organoids, targeting two different modalities of SARS-CoV-2 life cycle: cell entry via its receptor ACE2 and intracellular viral RNA replication. This combination treatment markedly improved their therapeutic windows against SARS-CoV-2
in both models. By using single amino-acid resolution screening in haploid ES cells, we report a singular critical pathway required for remdesivir toxicity, namely Adenylate Kinase 2. |
|
Montet, I, Phung, et al |
Information Psychiatrique |
Mental Health |
|
As SARS-CoV-2 spreads around the world, various hypotheses about factors involved in the spread of the virus are emerging,
including the protective role of nicotine. However, it has been known for decades that patients with chronic psychiatric conditions are much more likely to smoke. It also appears that patients hospitalized in psychiatric institutions were, at the end of the
lockdown period, much less affected by the coronavirus at the national level than professionals had feared. An observation was carried out in a unit dedicated to the care of infected patients in a hospital with psychiatric and follow-up care and rehabilitation
activities, in a region severely impacted by the disease (Île-de-France): the nicotine theory is discussed and confirms the interest of including in research programs the examination of the specificities of patients under psychiatric care, as well as sustained
attention to their somatic health condition. Psychotropic treatments could play a role in the mechanism of action of SARS-CoV-2. |
|
|
Moura, DTH, Proença, et al |
Clinics (Sao Paulo, Brazil) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to assess the prevalence and impact of gastrointestinal symptoms associated with COVID-19 in a large quaternary
referral center in South America. Diarrhea was the most common gastrointestinal symptom (17.25%). Patients with gastrointestinal symptoms had higher rates of concomitant constitutional symptoms, notably fatigue and myalgia (p<0.05). Gastrointestinal symptoms
were also more prevalent among patients on chronic immunosuppressants, ACE/ARB medications, and patient with chronic kidney disease (p<0.05). Laboratory results, length of hospitalization, ICU admission, ICU length of stay, need for mechanical ventilation,
vasopressor support, and in-hospital mortality did not differ based upon gastrointestinal symptoms (p>0.05). Regression analyses showed older age [OR 1.04 (95% CI, 1.02-1.06)], male gender [OR 1.94 (95% CI, 1.12-3.36)], and immunosuppression [OR 2.60 (95%
CI, 1.20-5.63)], were associated with increased mortality. |
|
|
Mouter, Niek, Hernandez, et al |
medRxiv |
Public Health response| Interventions de santé publique |
This study reports the results of 30,000 citizens advising the government on eight different possibilities for relaxing
lockdown measures in the Netherlands. By making use of the novel method Participatory Value Evaluation (PVE), participants were asked to recommend which out of the eight options they prefer to be relaxed. The results of the PVE informed policymakers about
peoples preferences regarding (the impacts of) the relaxation options. For instance, the authors established that participants assign an equal value to a reduction of 100 deaths among citizens younger than 70 years and a reduction of 168 deaths among citizens
older than 70 years. Citizens advised to relax lockdown measures, but not to the point at which the healthcare system becomes heavily overloaded. Found wide support for prioritising the re-opening of contact professions. Conversely, participants disfavoured
options to relax restrictions for specific groups of citizens as they found it important that decisions lead to unity and not to division. 80% of the participants state that PVE is a good method to let citizens participate in government decision-making on
relaxing lockdown measures. |
|
|
Mulchandani, R, Jones, et al |
BMJ |
Epidemiology| Épidémiologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Apply the AbC-19 Rapid Test lateral flow immunoassay for the detection of previous severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection, among key workers (healthcare staff, fire and rescue officers, and police officers) in England. AbC-19 sensitivity was lower among unselected populations than among PCR confirmed cases of SARS-CoV-2, highlighting the scope
for overestimation of assay performance in studies involving only PCR confirmed cases, owing to “spectrum bias.” |
|
|
Murray, DanielD, Babiker, et al |
medRxiv |
RCT |
Therapeutics for Inpatients with COVID-19 (TICO), is a global multi-arm, multi-stage (MAMS) platform master protocol,
which facilitates the rapid evaluation of the safety and efficacy of candidate anti-viral therapeutic agents for adults hospitalized with COVID-19. |
|
|
Naguib, MN, Raymond, et al |
J Pediatr Endocrinol Metab |
Long-Term Sequelae |
|
Multisystem inflammatory syndrome in children (MIS-C) is a unique clinical complication of SARS-CoV-2 infection observed
in pediatric patients. COVID-19 is emerging as a potential trigger for the development of diabetes in children. Here, we report an eight-year-old female presented with hyperglycemia, ketosis and metabolic acidosis consistent with diabetic ketoacidosis (DKA)
in the setting of fever, rash, respiratory distress, hemodynamic instability, reduced systolic function with dilation of the left anterior descending artery, and positive SARS-CoV-2 antibodies suggestive of MIS-C. |
|
|
Najafi, A, Sadeghniiat-Haghighi, et al |
Sleep Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to assess the frequency of COVID-19 and the effect of obstructive sleep apnea (OSA) management on
COVID-19 among patients with confirmed OSA. Design: Cross-sectional telephone interview survey. Setting: Academic sleep labs. Participants: Iranian adults ≥ 18 years old with confirmed OSA. Results suggest that OSA as a proinflammatory condition with multiple
comorbidities may be a contributing factor to developing COVID-19. Greater OSA severity, no treatment for OSA, and lower total sleep time and sleep efficiency were associated with increased COVID-19 prevalence among patients with OSA. |
|
|
A multi-agent system for simulating the spread of a contagious disease |
Nanna, GA, Quatraro, et al |
|
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique |
In this paper, we propose the use of a Multi-Agent system that extends the previous multi-agent-based approaches by
adding a whole new set of features to control the outbreak during the simulation in order to dynamically verify how the government strategies can impact the disease spread. |
|
Bifurcations and mutation hot-spots in the SARS-CoV-2
spike protein |
Niemi, Antti Juhani, Peng, et al |
bioRxiv |
Coronavirology| Coronavirologie |
This study presents a methodology to try and predict mutation hot-spot sites, where a small local change in spike
protein's structure can lead to a large scale conformational effect, and change the protein's biological function. |
|
Epidemiological and immunological features of obesity
and SARS-CoV-2 |
Nilles, Eric James, Siddiqui, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study examined the epidemiology and immunology of obesity and SARS-CoV-2 given the substantial global burden of
obesity and the uncertainties. Of 4469 individuals enrolled, 322 (7.21%) were seropositive. Adjusted seroprevalence was non-significantly lower with higher BMI. Obesity was associated with increased reporting of fever (OR 3.43 95% CI 1.58-7.60]) and multiple
other symptoms and aggregate measures. There were no identifiable differences in immune response between obese and non-obese individuals. |
|
Network interventions for managing the COVID-19 pandemic and sustaining economy |
Nishi, A, Dewey, et al |
Proc Natl Acad Sci U S A |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
Using agent-based simulations, authors show two network intervention strategies that divide or balance social groups
can substantially reduce transmission while sustaining economic activities. When the two strategies are jointly implemented without any additional measures, they can keep the effective reproduction number of COVID-19 around 1.0 in most cases. |
|
Nordeck, CD, Buresh, et al |
J Addict Med |
Public Health response| Interventions de santé publique |
Describes the adaptation of the Project Connections (PC) program, a low-threshold buprenorphine program in Baltimore,
in response to the COVID-19 pandemic. The PC program illustrates that offering on-demand, flexible treatment is an opportunity to increase opioid use disorder treatment access, even during a public health emergency that disrupted access to services. Relaxation
of buprenorphine telehealth regulations allowed for flexibility in treatment and benefits vulnerable populations. |
|
|
Obiała, J, Obiała, et al |
Health Policy and Technology |
Public Health response| Interventions de santé publique |
The aim of this study was to analyze accuracy of articles about COVID-19 prevention most frequently shared through
social media platforms. Most of the articles about COVID-19 prevention, identified as most frequently shared through social media platform during the pandemic, was found to be accurate. |
|
|
Oetjens, MT, Luo, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Performed a comprehensive quantitative assessment of pre-existing clinical phenotypes associated with COVID-19-related
hospitalization. Of 12,971 individuals tested for SARS-CoV-2 with sufficient pre-COVID-19 pandemic electronic health record (EHR) data at Geisinger, 1604 were SARS-CoV-2 positive and 354 required hospitalization. We identified 21 clinical phenotypes in 5 disease
categories meeting phenome-wide significance (P<1.60x10-4), including: six kidney phenotypes, e.g. end stage renal disease or stage 5 CKD (OR = 11.07), six cardiovascular phenotypes, e.g. congestive heart failure (OR = 3.8), five respiratory phenotypes, e.g.
chronic airway obstruction (OR = 2.54), and three metabolic phenotypes, e.g. type 2 diabetes (OR = 1.80). Additional analyses defining CKD based on estimated glomerular filtration rate, confirmed high risk of hospitalization associated with pre-existing stage
4 CKD (OR 2.90), stage 5 CKD/dialysis (OR 8.83), and kidney transplant (OR 14.98) but not stage 3 CKD (OR 1.03). |
|
|
Okeahalam, C, Williams, et al |
BMJ Open |
Epidemiology| Épidémiologie |
In sub-Saharan Africa, an increase in the number of nursing and midwifery personnel decreased the risk of COVID-19
deaths. A unit increase in universal healthcare (UHC) index of service coverage and low physical activity among adults increased the risk of COVID-19 mortality. An increase in the proportion of infants initiating breast feeding reduced the number of cases
per million, while an increase in higher life expectancy at birth increased the number of cases per million. |
|
|
EPIDEMIOLOGICAL AND CLINICAL CHARACTERISTICS OF COVID-19
PATIENTS IN KENYA |
Ombajo, Loice Achieng, Mutono, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We extracted demographic, laboratory, clinical and outcome data from medical records of RT-PCR confirmed SARS-CoV2
patients admitted in six hospitals in Kenya between March and September, 2020. |
|
Ong, SY, Stump, et al |
Applied clinical informatics |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
This article presents and describes our experience with evaluating and implementing inpatient telehealth technologies
in a large health care system with the goals of reducing use of PPE while enhancing communication for health care workers and patients. We discovered use cases for inpatient telehealth revealed as a result of an immense patient surge requiring large volumes
of PPE. In response, we assessed various consumer products to address the use cases for our health system. We identified 13 use cases and eight device options. During device setup and implementation, challenges and solutions were identified in five areas:
security/privacy, device availability and setup, device functionality, physical setup, and workflow and device usage. This enabled deployment of more than 1,800 devices for inpatient telehealth across seven hospitals with positive feedback from health care
staff. |
|
|
Osayomi, T, Adeleke, et al |
Spatial Information Research |
Epidemiology| Épidémiologie |
This paper analysed the geographical distribution of confirmed COVID-19 cases and fatalities in West Africa, with a
view to understanding why Nigeria is at the heart of the pandemic in the sub-continent. In order of importance, Nigeria, Ghana and Senegal were the top three on the morbidity list while Nigeria, Mali and Niger had the largest number of fatalities as at June
11, 2020. Results show that the population size and air traffic had significant impact on both COVID-19 morbidity and mortality in West Africa. In addition, Nigeria’s large population size and high air traffic volume increased its susceptibility to the viral
infection and accounted for its being an outlier in the sub-continent. |
|
|
Osborn, Jenna, Berman, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
This study presents a method that uses a dynamic spread function to systematically capture the continuous variation
in the population behavior throughout an epidemic. Uses the tool to quantify the reduction in infection rate realizable from the population of New York City adopting different facemask strategies during COVID-19. Assuming a baseline facemask of 67% filtration
efficiency, calculations show that increasing the efficiency to 75% could reduce the roughly 5000 new infections per day occurring at the peak of the epidemic by 40%. The turn-around time for the epidemic decreases from around 37 days to 31 days. Mitigation
strategies that may not be varied as part of the retrospective analysis, such as social distancing, are automatically captured as part of the calibration of the dynamic spread function. |
|
|
Othenin-Girard, A, Regamey, et al |
Swiss Med Wkly |
Long-Term Sequelae |
|
A 22-year-old male with a typical history of pauci-symptomatic COVID-19 3 weeks earlier, confirmed by positive serology
for SARS-CoV-2 (IgG), was admitted to the intensive care unit because of severe myocarditis with refractory cardiogenic shock that required extracorporeal life support. The initial clinical course was favourable with treatment. However, the patient subsequently
developed a severe mononeuritis multiplex leading to bilateral foot drop, which required intensive immunosuppressive therapy. |
|
|
Pahuja, S, Madan, et al |
J Occup Environ Med |
Epidemiology| Épidémiologie |
Assess the effect of ambient temperature, humidity and windspeed on disease occurrence in Delhi, India. The study finds
Increasing temperature decreases COVID-19 infectivity. |
|
|
Clinical severity of COVID-19 and general characteristics of Koreans |
Paik, Jean Kyung, Kwak, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to investigate the associations between clinical severity of COVID-19 and general characteristics
of the subjects using epidemiological data of 5,601 patients with confirmed COVID-19 in Korea. We found that severity of COVID-19 was greater among patients aged > 60 years, with obesity, clinical symptoms, respiratory diseases, kidney disease, and other diseases
(chronic liver disease, rheumatism/autoimmune disease, and dementia). Among the variables, women had reduced clinical severity of COVID-19. |
|
Paneroni, M, Simonelli, et al |
Am J Phys Med Rehabil |
Long-Term Sequelae |
|
In this cross-sectional study, we evaluated skeletal muscle strength and physical performance (1min- STS and SPPB tests),
dyspnea, fatigue and Single Breath Counting at discharge from a post-acute Covid Department, in patients recovering from COVID-19 pneumonia who had no locomotor disability prior to the infection. Significant correlations were observed between muscle strength
and physical performance indices (R from 0.31 to 0.69). The high prevalence of impairment in skeletal muscle strength and physical performance in hospitalized patients recovering from COVID-19 pneumonia without prior locomotor disabilities suggests the need
for rehabilitation programs after discharge. |
|
|
Pannu, Jessie, Ciotti, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique Animal model | Modèle animal |
This paper reports on developing an oil-in-water nanoemulsion (nanodroplet) formulation containing the potent antiseptic
0.13% Benzalkonium Chloride (NE-BZK) which demonstrated safe and broad anti-viral activity. Demonstrated that NE-BZK exhibits broad-spectrum, long-lasting antiviral activity with >99.99% in vitro killing of enveloped viruses including SARS-CoV-2, human coronavirus,
RSV and influenza B. Furthermore, in vitro studies demonstrated that NE-BZK continues to kill >99.99% of human coronavirus even when diluted 20-fold, while 0.13% aqueous BZK solution (AQ-BZK) did not. Ex vivo studies of NE-BZK on human cadaver skin demonstrated
persistent >99.99% killing of human coronavirus for at least 8 hours after application. AQ-BZK failed to demonstrate durable antimicrobial activity on skin over time. The repeated application of NE-BZK, twice daily for 2 weeks on to rabbit nostrils indicated
safety with no irritation. |
|
|
Patel, BrijeshV, Haar, et al |
medRxiv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Here, we present a data-driven analysis of granular, daily data from a representative proportion of patients undergoing
invasive mechanical ventilation (IMV) within the United Kingdom (UK) to evaluate the complete natural history of COVID-19. Data for 623 adults with COVID-19 who were mechanically ventilated between 01 March 2020 and 31 August 2020 were analyzed. A sizeable
proportion of patients with progressive worsening of hypoxaemia were also refractory to evidence-based ARDS strategies and showed a higher mortality. |
|
|
Pedersen, Eva Sophie Lunde, Collaud, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aims to collect epidemiological data in real time from people with Primary Ciliary Dyskinesia (PCD) throughout
the pandemic to describe incidence of COVID-19, symptoms, and course of disease; identify risk factors for prognosis; and assess experiences, wishes, and needs. The longitudinal study started recruitment on April 30, 2020, and 556 people with PCD completed
the baseline questionnaire by November 2, 2020. |
|
|
Chinese Parental Awareness of Protective Measures for Children During
COVID-19 Outbreaks |
Peng, Niang-Huei, Li, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
The aim of this research was to investigate Chinese parents’ awareness of pediatric COVID-19 in relation to protecting
their children. The survey included 1222 participants. 99.2% of participants were aware of respiratory transmission of COVID-19, and 75.6% also believed fecal-oral transmission to be possible. Although 98.3% of participants reported knowing how to properly
wear and remove masks, most parents were unaware of good handwashing technique and answered incorrectly regarding cough etiquette. Research participants seemed uncertain of children’s symptoms. Awareness scores of participants significantly differed across
parental role, educational attainment levels, and social-economic levels (P<0.005), with fathers, the better educated, and those of higher income showing higher levels of awareness. |
|
Sleep Disordered Breathing Among Hospitalized Patients due to COVID-19 |
Perger, E, Soranna, et al |
Am J Respir Crit Care Med |
Clinical data| Données cliniques |
Sought to correlate the presence and severity of sleep disordered breathing (SDB) with COVID-19 outcomes during hospitalization.
Consecutive patients, hospitalized at our Institution in Milan due to COVID-19 from April 8th to May 8th underwent a sleep apnea test (SAT). SAT were then scored after the recruitment period by a sleep clinician blinded to hospitalization outcomes. Our screened
sample included 93 subjects. Among them, 39 did not perform SAT as they were using 24 h non-invasive ventilation (NIV) due to COVID-19-related respiratory failure. Out of total 44 patients who underwent SAT, 13 were on oxygen treatment. 2 subjects were treated
with nocturnal continuous positive airway pressure (CPAP) due to their previous history of obstructive sleep apnea (OSA) and were included in the study. 33 patients (75%) had SDB, of which 15 (34%) presented mild SDB, 6 (14%) moderate SDB and 12 (27%) a severe
disease. Moreover, 15 (34%) patients showed OSA and 18 (41%) central sleep apnea (CSA). Of the 8 patients who had Cheyne-Stokes respiration with central sleep apnea (CSR-CSA) breathing, 1 had a history of stroke, 1 of renal failure, 3 of chronic ischemic cardiopathy
and 3 were in atrial fibrillation. 24 patients (52%) necessitated only oxygen support, while 22 (48%) needed NIV or invasive ventilation in the ICU. Ventilated patients were characterized by higher BMI, predominant OSA and greater obstructive AHI. |
|
Possible acute multifocal demyelinating lesions in a COVID-19 patient |
Pessoa Neto, AD, Alves, et al |
Arquivos de Neuro-Psiquiatria |
Clinical data| Données cliniques |
A 49-year-old man was admitted with cough, dyspnea, and fever. SARS-CoV-2 PCR from nasopharyngeal swab was positive.
Due to severe acute respiratory syndrome, he was intubated. On day 19, sedatives were held. On neurological examination, he was lethargic, with asymmetric quadriplegia (left>right) and global hyporeflexia. Brain magnetic resonance imaging revealed multifocal
brain lesions. He was treated with high-dose steroids and showed clinical and radiological improvement. |
|
COVID-19 deaths in South Africa: 99 days since South Africa’s first
death |
Pillay-Van Wyk, V, Bradshaw, et al |
South African Medical Journal |
Epidemiology| Épidémiologie |
Here, we aim to provide an epidemiological analysis of the first COVID-19 deaths in SA. SA reported 3 088 deaths from
COVID-19, i.e. an age-standardised death rate of 64.5 (95% confidence interval (CI) 62.3 - 66.8) deaths per million population. Most deaths occurred in Western Cape (65.5%) followed by Eastern Cape (16.8%) and Gauteng (11.3%). The median age of death was 61
years (interquartile range 52 - 71). Males had a 1.5 times higher death rate compared with females. |
|
Pintado, JF, Gibaja, et al |
Injury |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to examine the impact of the current COVID-19 outbreak on the number of non-COVID-related
patient presentations to a major national emergency traumatology/orthopedics referral center in Latin America. At our hospital, not all indications for traumatology/orthopedics service utilization declined despite the national government's directive to reduce
non-COVID-related consultations and admissions. Some disorders presented with even greater frequency, which must be considered when developing contingencies for the reallocation of healthcare resources during a pandemic. |
|
|
Pollock, NiraR, Savage, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
An ultrasensitive, quantitative electrochemiluminescence immunoassay for SARS-CoV-2 nucleocapsid (the MSD S-PLEX CoV-2
N assay) was used to measure Ag in clinical NP samples from adults and children previously tested by PCR. In 35 adult and 101 pediatric PCR-positive samples, sensitivity was 91% (95% CI, 77-98%) and 79% (70-87%), respectively. In samples with Ct < or = 35,
sensitivity was 100% (88-100%) and 96% (88-99%), respectively. In 50 adult and 40 pediatric PCR-negative specimens, specificity was 100% (93-100%) and 98% (87-100%), respectively. |
|
|
Puls, Alicia, Bracke, et al |
medRxiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
This paper focuses on data analytics regarding infection data of the COVID-19 pandemic including data heterogeneity,
spreading behavior, and lockdown impact, in Germany, Italy, Japan, New Zealand and France. |
|
|
Cutaneous eruption in COVID-19-infected patients in Thailand: An observational descriptive
study |
Punyaratabandhu, P, Chirachanakul, et al |
J Dermatol |
Clinical data| Données cliniques |
Observed the incidence, characteristics and relation of cutaneous eruption with COVID-19 at Bamrasnaradura Infectious
Diseases Institute. An observational descriptive study observed the incidence and characteristics of cutaneous eruption in 204 COVID-19-infected patients. We report five patients, who represented six incidences of skin eruption with four characteristics: maculopapular
rash (50%), acute generalized exanthematous pustulosis (16.67%), Stevens-Johnson syndrome (16.67%) and urticarial vasculitis (16.67%). Incidences of cutaneous eruption in COVID-19 at Bamrasnaradura Infectious Diseases Institute were low. Most of the incidents
were associated with medication used to treat COVID-19 infection, so drug allergy cannot be excluded as a cause of the rashes. |
|
Puylaert, CAJ, Scheijmans, et al |
Ann Surg |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
One in every 100 patients without COVID-19 symptoms tested positive for SARS-CoV-2 with RT-PCR; this yield increased
in conjunction with community prevalence. The added value of chest CT was limited. Preoperative screening allowed us to take adequate precautions for SARS-CoV-2 positive patients in a surgical population, whereas negative patients needed only routine procedures. |
|
|
ORF3a mediated-incomplete autophagy facilitates SARS-CoV-2
replication |
Qu, Yafei, Wang, et al |
bioRxiv |
Coronavirology| Coronavirologie |
In the present study, we found that SARS-CoV-2 infection triggers an incomplete autophagy response, elevated autophagosome
formation but impaired autophagosome maturation, and declined autophagy by genetic knockout of essential autophagic genes reduces SARS-CoV-2 replication efficiency. By screening 28 viral proteins of SARS-CoV-2, we demonstrated that expression of ORF3a alone
is sufficient to induce incomplete autophagy. Mechanistically, SARS-CoV-2 ORF3a interacts with autophagy regulator UVRAG to facilitate Beclin-1-Vps34-Atg14 complex but selectively inhibit Beclin-1-Vps34-UVRAG complex. Interestingly, although SARS-CoV ORF3a
shares 72.7% amino acid identity with the SARS-CoV-2 ORF3a, the former had no effect on cellular autophagy response. |
|
Rajaraman, S, Sornapudi, et al |
PLoS One |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study proposes a systematic approach to address limitations through application to the pandemic-caused need for
COVID-19 detection using chest X-rays (CXRs). We find that ensemble approaches markedly improved classification and localization performance, and that inter-reader variability and performance level assessment helps guide algorithm design and parameter optimization.
To the best of our knowledge, this is the first study to construct ensembles, perform ensemble-based disease ROI localization, and analyze inter-reader variability and algorithm performance for COVID-19 detection in CXRs. |
|
|
Rameshkumar, MR, Indu, et al |
Saudi Journal of Biological Sciences |
Therapeutics| Thérapeutique |
In this study, flavonoid compounds were analyzed for their inhibitory potential against important protein targets of
SARS-CoV-2 using computational approaches. A total of 458 flavonoid compounds were virtually screened against main protease target and 36 compounds were selected based on the interaction energy value >−9 kcal/mol. These compounds were individually docked against
protein targets and top 10 lead compounds were identified. Findings suggest that the screened compounds include Albireodelphin, Apigenin 7-(6″-malonylglucoside), Cyanidin-3-(p-coumaroyl)-rutinoside-5-glucoside, Delphinidin 3-O-beta-D-glucoside 5-O-(6-coumaroyl-beta-D-glucoside)
and (-)-Maackiain-3-O-glucosyl-6″-O-malonate could be the potent inhibitors of SARS-CoV-2 targets. |
|
|
Hemoperfusion with CytoSorb as Adjuvant Therapy in Critically Ill Patients with SARS-CoV2
Pneumonia |
Rampino, T, Gregorini, et al |
Blood Purif |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We report a preliminary experience of adjuvant therapy with Hemoperfusion (HP) in patients with SARS-CoV2 pneumonia.
In a scenario of dramatic medical emergency, we conducted an observational study on 9 consecutive patients hospitalized in COVID Intensive Care Unit, where 5 of 9 consecutive patients were treated with HP, due to the emergency overload made it impossible to
deliver blood purification in the other 4 patients. Our results show a better clinical course of T compared to control patients (C), in fact all T except 1 survived, and only 2 of them were intubated, while all C required intubation and died. |
|
Independent Dentists in the UK have less access to
Occupational Health |
Ranka, Satish, Ranka, et al |
medRxiv |
Mental Health |
|
The aim of this study was to assess if the dentists in the UK had access to occupational health (OH) and whether access
to the OH services helped during the pandemic. A survey link was sent to 200 dentists in the UK after the peak of the current pandemic. 124 dentists responded to the survey. The response rate was 62%. 59% of the dentists in the survey did not have access
to OH services in their workplace. Only 15% of dentists working in the independent sector had access to OH services compared to 78% working in the NHS or having NHS contracts. None of the dentists in the survey accessed OH services. |
|
Rapoport, E, Reisert, et al |
Child Abuse and Neglect |
Public Health response| Interventions de santé publique |
To assess associations between the pandemic public health response and the number of allegations of child abuse or
neglect. Methods: This study analyzed monthly data from New York City of the number of child maltreatment allegations, stratified by reporter type (e.g., mandated reporter, education personnel, healthcare personnel), as well as the number of Child Protective
Services (CPS) investigations warranting child welfare preventative services. Observed values were compared against predicted values. Substantially fewer allegations of child maltreatment were reported than expected in March (-28.8 %, deviation: 1848), April
(-51.5 %, deviation: 2976), and May 2020 (-46.0 %, deviation: 2959). Significant decreases in child maltreatment reporting were also noted for all reporter subtypes examined for March, April, and May 2020. Fewer CPS investigations warranted preventative services
than expected in March 2020 (-43.5 %, deviation: 303). In light of these findings, educators and healthcare providers must be especially vigilant when engaging online with children and their families for signs of child abuse and/or neglect. |
|
|
Ribeiro, BNF, Marchiori, et al |
Arquivos de Neuro-Psiquiatria |
Clinical data| Données cliniques |
A 26-year-old male patient was admitted with symptoms of cough and fever for three days. Chest CT showed multiple and
bilateral ground-glass opacities, predominantly peripheral, some with superimposed intralobular septal thickening. Nasopharyngeal swab for SARS-CoV-2 on RT-PCR assay was positive. On the eighth day of illness, he developed right facial weakness consistent
with facial nerve palsy. Magnetic resonance imaging of the brain showed enhancement of the right facial nerve. Neurological manifestations of COVID-19 have been associated with immune-mediated injuries rather than direct viral neurotropism, occurring in about
36% of patients, including strokes, vasculitis and Guillain-Barré. We emphasize that it is paramount to be aware of the possibility of facial paralysis in these patients. |
|
|
Rivas, ArielL, Hoogesteyn, et al |
medRxiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
Here we explore whether COVID-19 asymptomatic cases can be detected rapidly and cost-effectively, even when testing
is limited, and link the findings to economic data recently released. Findings denied any opposition between saving lives and saving the economy: there was no conflict between re-opening the economy (at the expense of public health) and stopping the epidemic
(at the expense of the economy). Public health and the economy support one another. It is suggested that, to materialize and expand a positive Public Health-economic relationship, current paradigms and disciplinary contents need to be re-assessed. |
|
|
Rutherford, BR, Choi, et al |
American Journal of Geriatric Psychiatry |
Mental Health |
|
Authors set out to quantify depressive (Hamilton Rating Scale for Depression HRSD]) and PTSD symptom (Post-traumatic
Stress Disorder Checklist PCL-5]) levels due to COVID-19. The findings are indicative of complexity in the responses of older individuals with PTSD to further stressful life events as well as possibly unique aspects to the COVID-19 pandemic as a stressor. |
|
|
Sadeghifar, Jamil, Jalilian, et al |
medRxiv |
Clinical data| Données cliniques |
This retrospective study aimed to analysis clinical outcomes of COVID-19 patients by disease symptoms in Ilam province
of Iran. Of 3608 patients, 3477 (96.1%) were discharged and 129 (3.9%) were died. 54.2% of the patients were male and were in the age group of 30-40 years old age. Cough, sore throat, shortness of breath or difficulty breathing and fever or chills were the
most common symptoms. People with symptoms of shortness of breath, abnormal radiographic findings of the chest, and chest pain and pressure were relatively more likely to die. Based on the findings of binary logistic regression probability of death in people
who showed shortness of breath, abnormal chest radiographic findings and chest pain was 1.34, 1.24 and 1.32 times higher than those who did not show these symptoms, respectively. |
|
|
Modelling the role of optimal social distancing on disease prevalence of COVID-19
epidemic |
Saha, S, Samanta, et al |
International Journal of Dynamics and Control |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique |
In this study, authors considered a SAIRS epidemiological model on COVID-19 transmission where people in the susceptible
environment move into asymptotically exposed class after coming contact with asymptotically exposed, symptomatically infected and even hospitalised people. Implementing control policies may help to reduce the disease transmission at this current pandemic situation
as these controls reduce the overall infected population and increase the recovered population. |
|
Detection of COVID-19 Disease from Chest X-Ray Images:
A Deep Transfer Learning Framework |
Sakib, Shadman, Siddique, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper, the implementation of a deep transfer learning-based framework using a pre-trained network (ResNet-50)
for detecting COVID-19 from the chest X-rays was done. Our dataset consists of 2905 chest X-ray images of three categories: COVID-19 affected (219 cases), Viral Pneumonia affected (1345 cases), and Normal Chest X-rays (1341 cases). The implemented neural network
demonstrates significant performance in classifying the cases with an overall accuracy of 96%. Most importantly, the model has shown significantly good performance over the current research-based methods in detecting the COVID-19 cases in the test dataset
(Precision = 1.00, Recall = 1.00, F1-score = 1.00, and Specificity = 1.00). Therefore, our proposed approach can be adapted as a reliable method for faster and accurate COVID-19 affected case detection. |
|
Assessment the Risk Perception of Health Care Workers of Covid-19 Disease |
Samadipour, Ezat, Ghardashi, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
To determine the Iranian healthcare workers' risk perception of the Covid-19 disease and the relevant effective factors.
From 165 participants, the youth (20-49 years of age) with 84% and the females with 60% constituted the majority of participants. The average risk perception score of the healthcare workers was 66.43±8.17. The Spearman correlation coefficient showed the significant
direct relationship between the risk perception score and all the sub-scales at 0.01 significance level. The political and cultural factors had the highest correlation with the personnel risk perception (r > 0.75). Health workers did not have an excellent
risk perception of the emergent Covid-19 disease. |
|
Schertzer, Daniel, Tchiguirinskaia, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We theoretically argue and empirically demonstrate that COVID-19 dynamics, during both growth and decline phases, is
a cascade with a rather universal scale symmetry whose power-law statistics drastically differ from those of an exponential process. This involves slower but longer phases which are furthermore linked by a fairly simple symmetry. These results explain biases
of epidemic models and help to improve them. Due to their generality, these results pave the way to a renewed approach to epidemics, and more generally to growth phenomena. |
|
|
Schuler, BA, Habermann, et al |
J Clin Invest |
Clinical data| Données cliniques Animal model | Modèle animal |
Integrating single-cell RNA sequencing (scRNA-seq) of developing mouse lung with temporally-resolved immunofluorescence
in mouse and human lung tissue, we found expression of SARS-CoV-2 Spike protein primer TMPRSS2 was highest in ciliated cells and type I alveolar epithelial cells (AT1), and TMPRSS2 expression increased with aging in mice and humans. Analysis of autopsy tissue
from fatal COVID-19 cases detected SARS-CoV-2 RNA most frequently in ciliated and secretory cells in airway epithelium and AT1 cells in peripheral lung. SARS-CoV-2 RNA was highly colocalized in cells expressing TMPRSS2. Together, these data demonstrate the
cellular spectrum infected by SARS-CoV-2 in lung epithelium and suggest that developmental regulation of TMPRSS2 may underlie the relative protection of infants and children from severe respiratory illness. |
|
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Anxiety and depression levels in Covid-19 disease and their relation to hypertension |
Sensoy, B, Gunes, et al |
Clin Exp Hypertens |
Epidemiology| Épidémiologie Mental Health |
|
A higher level of depression and a higher incidence of anxiety were demonstrated among applicants in the Covid-19 pandemic
(% 24 and % 44). Also a higher level of anxiety was demonstrated in hospitalized patients compared with the outpatient group. Different from the presence of depression symptoms, the presence of anxiety symptoms was associated independently with hypertension
in the study group. |
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In-silico drug repurposing for targeting SARS-CoV-2 main protease (M(pro)) |
Sharma, S, Deep, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We have performed in-silico drug repurposing followed by molecular dynamics (MD) simulation and MM-GBSA calculation.
The main protease (M(pro)) is one of the best-characterized drug targets among coronaviruses, therefore, this was screened for already known FDA approved drugs and some natural compounds. Comparison of docking and MD simulation results of complexes of drugs
with that of inhibitor N3 (experimentally obtained) suggests EGCG, withaferin, dolutegravir, artesunate as potential inhibitors of the main protease (M(pro)). Further, in silico docking and MD simulation suggest that EGCG analogues ZINC21992196 and ZINC 169337541
may act as a better inhibitor. |
|
Sheinson, Daniel, Wong, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique Healthcare Response | Réponse des soins de santé |
We modeled the impact of public and private sector contributions to developing diagnostic testing and treatments on
COVID-19-related healthcare resource use in the US. We estimated that public sector contributions lead to ≥30% reductions in COVID-19-related healthcare resource utilization. Private sector contributions to expanded diagnostic testing and treatments lead to
further reductions in mortality (-44%), intensive care unit (ICU) and non-ICU hospital beds (-30% and -28%, respectively), and ventilator use (-29%). The combination of lower diagnostic test sensitivity and proportions of patients self-isolating may exacerbate
case numbers, and policies that encourage self-isolating should be considered. While mechanisms exist to facilitate research, development, and patient access to diagnostic testing, future policies should focus on ensuring equitable patient access to both diagnostic
testing and treatments which, in turn, will alleviate COVID-19-related resource constraints. |
|
|
Shen, M, Liu, et al |
Frontiers in Genetics |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique zoonoses |
Here, we used the atomic structure model of SARS-CoV-2 and human ACE2 to assess the receptor utilization capacity of
ACE2s from 10 kinds of animals. Results show that chimpanzees, domestic cats and cattles are more susceptible to infection by SARS-CoV-2. All the eight tested compounds can effectively interfere with the binding of ACE2 and Spike protein, especially Nelfinavir,
providing drug candidates for the treatment and prevention of SARS-CoV-2. |
|
|
Economic impact of the first wave of the COVID-19
pandemic on acute care hospitals in Japan |
Shin, Jung-ho, Takada, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé Economics | Économie |
This study aimed to clarify the impact of the first wave of the pandemic, considered to be from March to May 2020,
on case volume and claimed hospital charges in acute care hospitals during this period. In the year-over-year comparisons, total claimed hospital charges decreased in April, May, June 2020 by 7%, 14%, and 5%, respectively, compared to the same months in 2019.
Our results also showed that per-case hospital charges increased during this period, possibly to compensate for the reduced case volumes. Regression results indicated that the hospital charges in April and May 2020 decreased by 6.3% for hospitals without COVID-19
patients. For hospitals with COVID-19 patients, there was an additional decrease in proportion with the length of hospital stay of COVID-19 patients including suspected cases. The mean additional decrease per COVID-19 patients was estimated to 5.5 million
JPY. |
|
Shorfuzzaman, M, Hossain, et al |
Sustain Cities Soc |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
In this paper, we propose a data-driven deep learning-based framework for the sustainable development of a smart city,
offering a timely response to combat the COVID-19 pandemic through mass video surveillance. To implementing social distancing monitoring, we used three deep learning-based real-time object detection models for the detection of people in videos captured with
a monocular camera. We validated the performance of our system using a real-world video surveillance dataset for effective deployment. |
|
|
Sidarta-Oliveira, D, Jara, et al |
Sci Rep |
Clinical data| Données cliniques |
Here we assembled a healthy human lung cell atlas meta-analysis with ~ 130,000 public single-cell transcriptomes and
show that key elements of the bradykinin, angiotensin and coagulation systems are co-expressed with ACE2 in alveolar cells and associated with their differentiation dynamics, which could explain how changes in ACE2 promoted by SARS-CoV-2 cell entry result
in the development of the three most severe clinical components of COVID-19. |
|
|
Siddiq, MustafaM, Chan, et al |
medRxiv |
Clinical data| Données cliniques |
We integrate cell biological and physiological analyses of human cardiomyocytes differentiated from human induced pluripotent
stem cells (hiPSCs) infected with SARS-CoV-2 in the presence of interleukins, with clinical findings, to investigate plausible mechanisms of cardiac disease in COVID-19 patients. We infected hiPSC-derived cardiomyocytes, from healthy human subjects, with SARS-CoV-2
in the absence and presence of interleukins. Our laboratory observations, combined with the clinical data, indicate that direct effects on cardiomyocytes by interleukins and SARS-CoV-2 infection can underlie the heart disease in COVID-19 patients. |
|
|
Bioinformatic study to discover natural molecules with activity against COVID-19 |
Singh, S, Florez, et al |
F1000Research |
Therapeutics| Thérapeutique |
We undertook this study to find the most probable drug candidate through a bioinformatics study. We virtually screened
the Zinc natural database using HTVS tool through molecular docking studies to analyze molecules recommended for the treatment of COVID-19. Ramipril benzyl ester, propafenone dimer and Lariciresinol are three important drugs found from the present study due
to their medicinal application which could be helpful in treating the disease. Stylopine, quillaic acid, cinobufagin, vitisinol C, segetalin A, scopolamine, 3-oxo glycyrrhetinic acid, conchinone B, lactimidomycin and cardinalins 4 are the other lead molecules
that could be used as therapeutics against COVID-19 disease. |
|
Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding |
Slaats, MALJ, Versteylen, et al |
Journal of Infection and Public Health |
Clinical data| Données cliniques |
We present a case of a neonate with a high viral load and prolonged virus shedding. A 7-day-old boy was admitted to
the hospital with fever, lethargy and apnoea. He was found SARS-CoV-2 RNA positive with an exceptionally high viral load in nasopharyngeal swab and stool. The father and two maternity nurses at home had detectable SARS-CoV-2 RNA as well. |
|
Sousa, TatianeCM, Moreira, et al |
medRxiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
We developed an RT-PCR testing intensity effort index (RT-PCR TIEI) composed of seven indicators to assess the intensity
testing efforts in the state of São Paulo. We used dynamic time-series cross-sectional models to analyze the association between the RT-PCR TIEI in São Paulo state, the proportion of the population living under a high socioeconomic vulnerability level, dependent
on public health service (SUS), per capita income, and population density. On average, the RT-PCR TIEI score was 23.50. The maximum (47.06) was reached in week 11 and declined in subsequent weeks. The lowest score (17.65) was reached in week 25. In the long-run,
the RT-PCR TIEI is negatively associated with socioeconomic vulnerability (p-value=0.000, 95% CI -0.896, -0.816), with a higher proportion of the population dependent on SUS (p-value= 0.000, 95% CI -0.877, 0.808) and with population density (p-value=0.000,
95% CI -0.857; -0.806). There was a decline in the state’s testing intensity as the pandemic advanced, and the most socioeconomic vulnerable RHDs showed the lowest values where local public laboratory presence is a predictor of a higher RT-PCR TIEI score.
Thus, the low testing RT-PCR effort and local laboratory inequality affect surveillance capability, especially for the most socioeconomic vulnerable population. |
|
|
A systematic approach for COVID-19 predictions and parameter estimation |
Srivastava, V, Srivastava, et al |
Personal and Ubiquitous Computing |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this research the Susceptible-Infectious-Recovered model with different conditions has been used for the analysis
of COVID-19. The effects of lockdown, the light switch method, and parameter variations like contact ratio and reproduction number are also analyzed. The authors have attempted to study and predict the lockdown effect, particularly in India in terms of infected
and recovered numbers, which show substantial improvement. |
|
Will vaccine hesitancy compromise our efforts to face the next SARS-CoV-2 epidemic
wave? |
Sticchi, L, Taramasso, et al |
Hum Vaccin Immunother |
Public Health response| Interventions de santé publique |
We have checked the vaccination history of 389 elderly patients (62.9% males, mean age of 78.5 + 8.4 years) hospitalized
for SARS-CoV-2 pneumonia. Information regarding pneumococcal vaccination was available for 354 patients (91.0%): the overall vaccination coverage rate (VCR) was 19.8% (70/354), 11.3% received only 13-valent pneumococcal conjugate vaccine (PCV13), 3.4% were
immunized with 23-valent pneumococcal polysaccharide vaccine (PPSV23), 5.1% received both vaccines. VCR among the elderly population in Liguria Region was 26.2% (118,581/453,082), among them 13.7% received PCV13, 12.4% were immunized with at least one dose
of PPSV23. Regarding the 2019-2020 influenza season vaccination data were available for 46 patients: 59% of them were immunized. VCR in the elderly population was 51.7% (234,153/453,082). |
|
Stout, Robert, Rigatti, et al |
medRxiv |
Epidemiology| Épidémiologie Immunology | Immunologie |
This study aimed to determine the seroprevalence and 3 month temporal change of SARS−COV−2 in the US and Puerto Rico
in an asymptomatic well population. The prevalence of SARS−CoV−2 in the asymptomatic population has doubled during the May to September time period, going from 3.0% to 6.6%. Positive serology to SARS−COV−2 was similar in males and females but varies by age.
The greatest increase was in the youngest population. Based on the September prevalence it is estimated that there are 11.1 million (bootstrap 95% CI: 10.8 − 11.5 million) asymptomatic SARS−CoV−2 infections in the US, which is 1.95 times the cumulative number
of cases in the US reported to the CDC as of September 1, 2020. |
|
|
Sun, Y, Song, et al |
Int J Soc Psychiatry |
Mental Health |
|
This study aims to investigate coronavirus disease-related occupational stress and its single and cumulative effect
on mental health and self-efficacy among community mental health care workers (CMHWs) in China. CMHWs did not show high level of depression or anxiety in this study. Those who provided service for suspected people who were quarantined reported higher risk
of depression and anxiety. CMHWs with two different types of work had 0.996 times more risk of depression than those with only one type of work. |
|
|
The Individual and Social Determinants of COVID-19
in Ontario, Canada: A Population-Wide Study |
Sundaram, Maria, Calzavara, et al |
medRxiv |
Epidemiology| Épidémiologie |
We conducted cross-sectional analyses in Ontario, Canada comparing individual, environmental, and social determinants
among individuals who were tested versus not yet tested. Of a total of 14,695,579 individuals, 758,691 had been tested, of whom 25,030 (3.3%) tested positive. Residing in areas with highest household density (aOR: 2.08; 95% CI: 1.95-1.21), lowest educational
attainment (aOR: 1.52; 95% CI: 1.44-1.60), and highest proportion of recent immigrants (aOR: 1.12; 95% CI: 1.07-1.16) were consistently related to increased odds of COVID-19 across analytic designs. |
|
Tan, LS, Huang, et al |
American Journal of Translational Research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this cohort study was to investigate the association of AKI with clinical outcomes in COVID-19 patients.
We reviewed electronic medical data from patients with COVID-19 in Shenzhen from January 11 to February 19, 2020. Clinical features and clinical outcomes in COVID-19 patients with and without AKI were analyzed. Further, we evaluated the association between
AKI development and clinical outcomes. 9.6% patients developed AKI during hospitalization. Those with AKI were older, had more severe pneumonia, more comorbidity and lower lymphocyte count. More patients (77.5%) had primary composite outcomes (ICU admission,
use of high-flow nasal cannula and mechanical ventilation) in AKI group compared to non-AKI group. The median length of stay (LOS) and ICU stay were longer among those with AKI. After adjusting for related covariates, AKI development was independently correlated
with LOS (β 9.16 ), rather than primary outcomes (HR 1.34) in COVID-19 patients. |
|
|
Tang, B, Zhu, et al |
Frontiers in Cell and Developmental Biology |
Clinical data| Données cliniques Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study, we confirmed that significantly differentially expressed genes in COVID-19 patients were mainly involved
in the regulation of immune and inflammation-related signaling pathways. To explore the susceptibility factors of cancer patients, we assessed the expression of ACE2, TMPRSS2, and the endocytic regulator AAK1 in lung adenocarcinoma (LUAD) patients and explored
their effects on immune infiltration. We also identified miR-432-5p as a potential targeted molecule and bexarotene as a potential targeted drug of the three genes through bioinformatic analysis. |
|
|
Impact of the COVID-19 pandemic on sexually transmitted infection clinic visits |
Tao, J, Napoleon, et al |
Sex Transm Dis |
Healthcare Response | Réponse des soins de santé |
Coronavirus disease (COVID-19) is responsible for a global pandemic and has impacted health care accessibility and
delivery. Clinic data was reviewed for a sexually transmitted infection (STI) clinic from September, 2019 to May, 2020. A significant decrease in rates of STIs visits and treatments during the COVID-19 pandemic was observed. |
|
Tavabie, OD, Clough, et al |
Frontline Gastroenterology |
Healthcare Response | Réponse des soins de santé |
We aimed to understand the impact of the response to COVID-19 on the outcomes of upper gastrointestinal (UGI) bleeds.
Endoscopy for UGI bleeds in the COVID-19 era is associated with reduced survival. No clear cause has been identified but we suspect that this is a secondary effect of the response to the COVID-19 pandemic. |
|
|
Tavernier, E, McNicholas, et al |
BMJ Open |
RCT |
INTRODUCTION: Prone positioning (PP) is an effective first-line intervention to treat patients with moderate to severe
acute respiratory distress syndrome (ARDS) receiving invasive mechanical ventilation, as it improves gas exchanges and reduces mortality. The use of PP in awake spontaneous breathing patients with ARDS secondary to COVID-19 was reported to improve oxygenation
in few retrospective trials with small sample size. High-level evidence of awake PP for hypoxaemic patients with COVID-19 patients is still lacking. METHODS AND ANALYSIS: The protocol of this meta-trial is a prospective collaborative individual participant
data meta-analysis of randomised controlled open label superiority trials. This design is particularly adapted to a rapid scientific response in the pandemic setting. It will take place in multiple sites, among others in USA, Canada, Ireland, France and Spain.
Patients will be followed up for 28 days. Patients will be randomised to receive whether awake PP and nasal high flow therapy or standard medical treatment and nasal high flow therapy. Primary outcome is defined as the occurrence rate of tracheal intubation
or death up to day 28. An interim analysis plan has been set up on aggregated data from the participating research groups. ETHICS AND DISSEMINATION: Ethics approvals were obtained in all participating countries. Results of the meta-trial will be submitted
for publication in a peer-reviewed journal. Each randomised controlled trial was registered individually, as follows: NCT04325906, NCT04347941, NCT04358939, NCT04395144 and NCT04391140. |
|
|
Severe hyperphosphatasemia and severe acute respiratory syndrome coronavirus
2 infection in children |
Tchidjou, HK, Caron, et al |
Blood Coagul Fibrinolysis |
Clinical data| Données cliniques |
We reported the first infant case of severe hyperphosphatasemia because of SARS-CoV-2 infection, in a 9-month-old child
admitted to the Pediatric Covid-19 Unit of Amiens University Hospital. |
|
Dynamical Analysis of Stochastic COVID-19 Model with Jump-Diffusion |
Tesfay, Almaz, Tesfay, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
For a stochastic COVID-19 model with jump-diffusion, we prove the existence and uniqueness of the global positive solution
of this model. We also investigate some conditions for the extinction and persistence of the disease. We calculate the threshold of the epidemic system for different values of the noise. This threshold is denoted by ξ that depends on the white and jump noises.
When the noise is large or small, our numerical findings show that the COVID-19 vanishes from the people if ξ1. |
|
Tomasoni, D, Inciardi, et al |
Eur J Heart Fail |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aims to assess the prognostic value of a history of heart failure (HF) in patients with COVID-19. We enrolled
692 consecutive patients admitted for COVID-19 in 13 Italian cardiology centres between 1st March and 9th April, 2020. In-hospital death occurred in 37 of 90 patients (41.1%) with HF history versus 126 of those with no HF history (20.9%). The increased risk
of death associated with HF history remained significant after adjustment for clinical variables related to COVID-19 and HF severity, including comorbidities, oxygen saturation, lymphocyte count and plasma troponin. Patients with a history of HF also had
more in-hospital complications including acute HF (33.3% vs 5.1%, p<0.001), acute renal failure (28.1% vs 12.9%, p<0.001), multiorgan failure (15.9% vs 5.8%, p=0.004) and sepsis (18.4% vs 8.9%, p=0.006). Hospitalized patients with COVID-19 and a history of
HF have an extremely poor outcome with higher mortality and in-hospital complications. |
|
|
Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19 |
Tosif, S, Neeland, et al |
Nat Commun |
Clinical data| Données cliniques Immunology | Immunologie |
Here, we describe clinical features, virology, longitudinal cellular, and cytokine immune profile, SARS-CoV-2-specific
serology and salivary antibody responses in a family of two parents with PCR-confirmed symptomatic SARS-CoV-2 infection and their three children, who tested repeatedly SARS-CoV-2 PCR negative. All family members have salivary anti-SARS-CoV-2 antibodies detected,
predominantly IgA, that coincide with symptom resolution in 3 of 4 symptomatic members. Plasma from both parents and one child have IgG antibody against the S1 protein and virus-neutralizing activity detected. These data indicate that children can mount an
immune response to SARS-CoV-2 without virological confirmation of infection, raising the possibility that immunity in children can prevent the establishment of SARS-CoV-2 infection. |
|
Vadász, I, Husain-Syed, et al |
Thorax |
Long-Term Sequelae |
|
We describe the clinical, radiological and histological findings of patients with COVID‑19-associated acute respiratory
distress syndrome who later developed severe organising pneumonia including longitudinal follow-up. Our findings may have important implications for the therapeutic modalities in the late-phase of severe COVID‑19 and might partially explain why a subgroup
of COVID‑19 patients benefits from systemic corticosteroids. |
|
|
Vascular obliteration because of endothelial and myointimal growth in COVID-19 patients |
Valtueña, J, Martínez-García, et al |
Int J Dermatol |
Clinical data| Données cliniques |
This study aimed to examine the histology of skin lesions in COVID-19 patients to better understand the disease's pathology.
Five skin lesions from COVID-19 adult patients were selected for a deep histological tissue examination. A strong vasculopathic reaction pattern based on prominent vascular endothelial and myointimal cell growth was identified. Endothelial cell distortion
generated vascular lumen obliteration and striking erythrocyte and serum extravasation. Significant deposition of C4d and C3 throughout the vascular cell wall was also identified. COVID-19 could comprise an obliterative microangiopathy consisting on endothelial
and myointimal growth with complement activation. This mechanism, together with the increased vascular permeability identified, could contribute to obliteration of the vascular lumen and hemorrhage in COVID-19. |
|
Public Trust in Healthcare System and Its Correlates during the COVID-19
Epidemic in Iran |
Vardanjani, Hossein Molavi, Imanieh, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
To rapidly assess the public trust in the healthcare system during the COVID-19 epidemic and its correlates in Iran.
A total of 5250 adults (response rate: 76%) were participated in the study. Mean of reported trust scores was 50.3±22.8, and of fear scores was 72.0±17.8. Being male (p=0.006), higher levels of education (p<0.001) and socio-economic status (p<0.001), and higher
fear scores (p<0.001) were independently correlated with trust in healthcare system. |
|
Daily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19:
a Case Series |
Vetter, P, Eberhardt, et al |
mSphere |
Clinical data| Données cliniques Immunology | Immunologie |
We monitored shedding of viral RNA and infectious virus and characterized the immune response kinetics of the first
five patients quarantined in Geneva, Switzerland. High viral loads and infectious virus shedding were observed from the respiratory tract despite mild symptoms, with isolation of infectious virus and prolonged positivity by reverse transcriptase PCR (RT-PCR)
until days 7 and 19 after symptom onset, respectively. Robust innate responses characterized by increases in activated CD14(+) CD16(+) monocytes and cytokine responses were observed as early as 2 days after symptom onset. |
|
A multi-institutional assessment of COVID-19-related risk in radiation oncology |
Viscariello, N, Evans, et al |
Radiotherapy and Oncology |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to assess potential safety impacts of control measures employed during the COVID-19
pandemic. Methods: A multi-institutional study was undertaken to assess the risks of pandemic-associated workflow adaptations using failure mode and effects analysis (FMEA). Results: Thirty three failure modes and 22 control measures were identified. Control
measures resulted in risk score reductions for 22 of the failure modes, with the largest reductions from screening of patients and staff, requiring use of masks, and regular cleaning of patient areas. |
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Drivers of acceptance of COVID-19 proximity tracing
apps in Switzerland |
von Wyl, Viktor, Hoeglinger, et al |
medRxiv |
Public Health response| Interventions de santé publique |
The aim of this study was to investigate SwissCovid app coverage and reasons for not using the app in Switzerland during
a time of increasing SARS-CoV-2 incidence. By use of data collected between 28.09.2020 to 08.10.2020 for a nationwide online panel survey (Covid-19 Social Monitor, n=1,511 participants), socio-demographic and behavioral factors associated with app usage were
examined using multivariable logistic regression. Overall, 46.5% of participants reported using the SwissCovid app (up from 43.9% in a study wave conducted in July 2020). A higher monthly household income (e.g. OR 1.92 1.40-2.64] for an income >CHF 10,000
vs. an income <; CHF 6,000), more frequent internet use (e.g., daily (reference) vs. less than weekly OR 0.37 0.16-0.85]), better adherence to mask-wearing recommendations (e.g., always or most of the time (reference) vs. rarely or never OR 0.28 0.15-0.52]),
and being a non-smoker (OR 1.32 1.01-1.71]) were associated with an increased likelihood for app uptake. Citizenship status (e.g., non-Swiss citizenship 0.61 0.43-0.87] vs. Swiss citizenship only), and language region (French 0.61 0.46-0.80], vs. Swiss German)
were associated with a lower app uptake probability. In a randomly selected subsample (n=711) with more detailed information, higher levels of trust in government and health authorities were additionally associated with a higher app uptake probability (e.g.,
OR 3.13 1.58-6.22] for high vs. low trust (reference)). The most frequent reasons for app non-use was lack of perceived benefit of the app (36.8%), 22.8% reported to have no compatible phone, and 22.4% had privacy concerns. |
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Wang, L, Lin, et al |
Sci Rep |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this study we introduce COVID-Net, a deep convolutional neural network design tailored for the detection of COVID-19
cases from chest X-ray (CXR) images that is open source and available to the general public. We also introduce COVIDx, an open access benchmark dataset that we generated comprising of 13,975 CXR images across 13,870 patient patient cases, with the largest
number of publicly available COVID-19 positive cases to the best of the authors' knowledge. Furthermore, we investigate how COVID-Net makes predictions using an explainability method in an attempt to not only gain deeper insights into critical factors associated
with COVID cases. |
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Wang, S, Chen, et al |
PLoS One |
Clinical data| Données cliniques |
We aimed to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China. Of 199 discharged
patients with COVID-19, 105 patients were male, with a median age of 46.3 years, and 17 patients were severe, and 5 patients were critical on admission. Hypertension and diabetes were the most common comorbidities. The symptoms at illness onset were mainly
fever (76.4%), cough (60.8%), and myalgia or fatigue (27.6%). A total of 96.5% of patients had abnormal imaging findings on chest computed tomography. Lymphopenia (37.2%) and hypoxemia (13.6%) were observed. Patients in Fujian Province were mostly nonsevere
cases with mild or moderate symptoms, and had a lower mortality than patients in Wuhan (4.3%-15%). |
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Sputum characteristics and airway clearance methods in patients with severe COVID-19 |
Wang, Y, Zhang, et al |
Medicine (Baltimore) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In our study, we found that elderly COVID-19 patients were more susceptible to progression to critical illness (P = .024)
and were likely to have accompanying lymphopenia (P = .035) or increased neutrophil counts (P = .019). We observed that there was a higher proportion of patients with Grade 3 sticky sputum in the critically ill group than in the noncritically ill group (P = .026),
suggesting that changes in sputum characteristics may be one of the early warning signs of critical COVID-19. In addition, we found that the application rates of large doses of ambroxol (P = .043) and prone-position drainage (P = .037) were relatively high
in COVID-19 patients with good prognoses, suggesting that the early application of large doses of expectorant drugs and prone-position drainage in COVID-19 patients may avoid progression to critical illness and improve the prognosis. |
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Weiss, TT, Cerda, et al |
British journal of anaesthesia |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We conducted a retrospective observational cohort study of critically ill intubated patients with COVID-19 who were
placed in the prone position between March 18, 2020 and March 31, 2020. After the first prone positioning session, Pao2/Fio2 (mean (standard deviation)) ratio increased from 17.9 kPa to 28.2 kPa. After the initial prone positioning session, subjects who were
discharged from hospital were more likely to have an improvement in Pao2/Fio2 ratio ≥20%, compared with those requiring ECMO or who died. Patients with COVID-19 acute respiratory distress syndrome frequently responded to initial prone positioning with improved
oxygenation. Subsequent prone positioning in subjects discharged from hospital was associated with greater improvements in oxygenation. |
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Wendt, FrankR, De Lillo, et al |
medRxiv |
Epidemiology| Épidémiologie |
To distinguish correlation from causation, we performed in-silico analyses of three COVID-19 outcomes (N>1,000,000).
We show genetic correlation and putative causality with depressive symptoms, metformin use, and alcohol use. COVID-19 risk loci associated with several hematologic biomarkers. Comprehensive findings inform genetic contributions to COVID-19 epidemiology, molecular
mechanisms, and risk factors. |
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Wright, Liam, Fancourt, et al |
medRxiv |
Public Health response| Interventions de santé publique |
We used data from the UCL COVID-19 Social Study; a large weekly panel of UK adults from first five months of lockdown
in the UK (n = 21,000). We tested whether the extent to which demographic, socio-economic position, personality traits, pro-social motivations, and the living environment predict compliance changed across the pandemic. Low compliance was strongly related to
younger age and also to risk attitudes, empathic concern, and high income, among other factors. But the size of some of these associations was larger in later months when less stringent lockdown and household mixing measures were in place, suggesting context-specific
effects. The results also showed that compliance fell faster across some groups, suggesting the importance that public health communications adopt a plurality of messages to maximize broad adherence. |
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Wu, Y, Zhang, et al |
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Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Taking Shenzhen, a city with strong comprehensive economic level, as an example, this paper uses data processing to
select six major influencing factors, such as medical treatment and environment, and uses the method of regression and fitting crossover analysis to establish the fitting curve between factors and people's health level for prediction, and obtains the regression
equation. On this basis, T-S Fuzzy Neural Network (T-S FNN) is used to divide the evaluation grade of regression model, make an effective evaluation of multiple factors of people's physical health level, establish a comprehensive prediction evaluation model,
and obtain the gradient grade of factors affecting people's physical health correlation and their own direct factors. |
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Xia, L, Shi, et al |
Phytomedicine |
Clinical data| Données cliniques Therapeutics| Thérapeutique Immunology | Immunologie
Animal model | Modèle animal |
This study aimed to evaluate the antiviral and anti-inflammatory properties, and to discover the mechanism of action
and the clinical effectiveness of SFJDC as a potential drug for the treatment of COVID-19. We analyzed the antiviral and anti-inflammatory effects of SFJDC in a HCoV-229E mouse model on lung index, virus load in the lung, the release of cytokines, and on
T- and B-lymphocytes. The mechanism of action was further investigated by network analysis. We investigated data from a clinical pragmatic real-world study for patients with confirmed COVID-19, to evaluate the clinical effect of SFJDC and to determine the
best time to start the treatment. SFJDC significantly reduced the virus load in the lung of HCoV-229E mice (from 1109.29 ± 696.75 to 0 ± 0 copies/ml), decreased inflammatory factors IL-6, IL-10, TNF-α, and IFN-γ in the lung, and increased the amount of CD4+
and CD8+ cells in the blood compared to the model group. Network analysis revealed that SFJDC reduces the activity of NFκB via several signaling pathways.Clinical data showed that SFJDC, added to standard antiviral therapy (AVD), significantly reduced the
clinical recovery time of COVID-19 and fatigue (from 3.55 ± 4.09 to 1.19 ± 2.28 days) as well as cough (from 5.67 ± 5.64 to 3.47 ± 3.75) days compared to AVD alone. SFJDC therapy was significantly more effective when used within the first 8 days after the
onset of symptoms. |
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Xiang, C, Huang, et al |
Medicine (Baltimore) |
Clinical data| Données cliniques |
This study aims to describe the mobile chest X-ray manifestations of deceased patients with COVID-19. Fifty-four deceased
patients with COVID-19 were included in the study. We found that 50 (93%) patients with lesions occurred in the bilateral lung, 4 (7%) patients occurred in the right lung, 54 (100%) patients were multifocal involvement. The number of lung fields involved was
42 (78%) patients in 6 fields, 3 (6%) patients in 5 lung fields, 4 (7%) patients in 4 lung fields, and 5 (9%) patients in 3 lung fields. The mobile chest X-ray manifestations of deceased patients with COVID-19 were mostly bilateral lung, multifocal involvement,
and extensive lung field, and pleural effusion, pleural thickening, and pneumothorax probably could be observed. The serial mobile chest X-ray showed that the chest lesions were progressive with a high probability. |
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Physical Activity, Screen Time, and Mood Disturbance Among Chinese Adolescents
During COVID-19 |
Xiao, S, Yan, et al |
J Psychosoc Nurs Ment Health Serv |
Mental Health |
|
The purpose of the current study was to explore the physical activity and screen time status among Chinese adolescents
during the COVID-19 lockdown and their association with mood disturbance and conflicts with parents. Physical activity, particularly of at least 150 minutes' duration each week, significantly decreased the likelihood of negative mood among adolescents during
lockdown. Screen time, specifically other than that spent on online study, had a negative association with mood, after controlling for the relevant variables (i.e., physical activity and body mass index). Less screen time and accumulating 150 minutes of physical
activity were associated with fewer conflicts with parents. |
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Yalçin, KS, Kasapoğlu, et al |
Blood Coagul Fibrinolysis |
Clinical data| Données cliniques |
This study aimed to evaluate the relationship between serum D-dimer levels and tomography findings at the time of admission
in patients diagnosed with COVID-19. This study included 94 patients, 48 women (51%) and 46 men (49%), diagnosed by PCR method. Patients with thorax tomography findings were having significantly higher D-dimer levels (P = 0.001). Patients with oxygen desaturation
were having significantly higher D-dimer levels than the patients with normal oxygen saturations (P = 0.001). There was a significant negative correlation between oxygen saturation and D-dimer levels in all patients with and without tomography findings (r = -0.301,
P = 0.016). Similarly, there was a significant positive correlation between the oxygen saturation and the lymphocyte count (r = 0.300, P < 0.017). |
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Yamazaki, Wataru, Matsumura, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
To diagnose COVID-19 patients in the field, a sensitive point-of-care test using saliva was developed. Using a heat
block without centrifuge, the test took 45 minutes. Naked eye judgement with color change dye outperformed the reference standard, with a diagnostic sensitivity of 82.6% (19/23) and diagnostic specificity of 100% (21/21). |
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Yepes-Perez, Andres, Herrera-Calderón, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We investigated the antiviral potential of the hydroalcoholic extract of Uncaria tomentosa stem bark from Peru against
SARS-CoV-2 in vitro. The antiviral activity of U. tomentosa against SARS-CoV-2 in vitro was assessed in Vero E6 cells using cytopathic effect (CPE) and plaque reduction assay. After 48h of treatment, U. tomentosa showed an inhibition of 92.7 % of SARS-CoV-2
at 25.0 µg/mL (p<0.0001) by plaque reduction assay on Vero E6 cells. In addition, U. tomentosa, induced a reduction of 98.6 % (p=0.02) and 92.7 % (p=0.03) in the CPE caused by SARS-CoV-2 on Vero E6 cells at 25 µg/mL and 12.5 µg/mL, respectively. The EC50 calculated
for U. tomentosa extract by plaque reduction assay was 6.6 µg/mL (4.89 – 8.85 µg/mL) for a selectivity index of 4.1. The EC50 calculated for U. tomentosa extract by TCID50 assay was 2.57 µg/mL (1.05 – 3.75 µg/mL) for a selectivity index of 10.54. These results
showed that U. tomentosa known as Cat’s claw has antiviral effect against SARS-CoV-2 observed as a reduction in the viral titer and CPE after 48h of treatment on Vero E6 cells. |
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VIRAL MENINGITIS ASSOCIATED WITH COVID-19 IN A 9-YEAR-OLD CHILD: A CASE REPORT |
Yousefi, K, Poorbarat, et al |
Pediatr Infect Dis J |
Clinical data| Données cliniques |
We report first viral meningitis associated with coronavirus disease 2019 (COVID-19) in a patient hospitalized at Imam
Hassan Hospital in Bojnurd. The patient was a 9-year-old child with no history of internal disease who referred to the emergency with a complaint of fever, headache and low back pain, about 3 days after the onset of symptoms. finally, viral meningitis was
diagnosed with COVID-19. |
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Zhang, Y, Xiang, et al |
BMJ Mil Health |
Mental Health |
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This study aimed to explore the impact of COVID-19 on a regional referral centre of the United Nations Mission in South
Sudan where medical supply and manpower are extremely insufficient. The number of outpatients decreased slightly after the COVID-19 outbreak, whereas the weekly hospital length of stay of inpatients increased significantly. Total weekly working hours increased.
Elevated mental stress was documented among healthcare providers after the outbreak. The threat of COVID-19 infection, delay in rotation and family-related concerns constituted the main stressors. |
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Zheng, H, Li, et al |
PLoS Pathog |
Immunology | Immunologie Animal model | Modèle animal |
To better understand the pathogenesis caused by SARS-CoV-2, we developed a rhesus macaque model to mimic natural infection
via the nasal route, resulting in the SARS-CoV-2 virus shedding in the nose and stool up to 27 days. Importantly, we observed the pathological progression of marked interstitial pneumonia in the infected animals on 5-7 dpi, with virus dissemination widely
occurring in the lower respiratory tract and lymph nodes, and viral RNA was consistently detected from 5 to 21 dpi. During the infection period, the kinetics response of T cells was revealed to contribute to COVID-19 progression. Our findings implied that
the antiviral response of T cells was suppressed after 3 days post infection, which might be related to increases in the Treg cell population in PBMCs. |
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First patient management of COVID-19 in Changsha, China: a case report |
Zhou, J, Cao, et al |
BMC Infect Dis |
Clinical data| Données cliniques |
Here, we report the first patient cured of COVID-19 infection in Changsha, China, and the symptoms, diagnosis, treatment,
and management of this patient are all described in this report. |
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Zhou, M, Yu, et al |
American Journal of Translational Research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to delineate the clinical characteristics associated with long-term viral shedding (>21 days) in patients
with COVID-19. Factors associated with long-term (>21 days) SARS-CoV-2 RNA shedding were evaluated in a cohort of 609 patients from two hospitals in Wuhan. The median duration of SARS-CoV-2 viral shedding was 19 days among all patients. 42% of patients
had a prolonged viral shedding time (>21 days), in which the longest viral shedding time was 58 days. When comparing patients with early (≤21 days) and late viral RNA clearance (>21 days), prolonged viral shedding was associated with age <65 (P=0.015), female
sex (P=0.028), cough (P=0.025), fatigue (P=0.035), sore throat (P=0.013), aspartate aminotransferase (P=0.038), procalcitonin (P=0.010), albumin (P=0.003), D-dimer (P=0.011), lung involvement (P=0.014), reticular shadow (P<0.001) and lung consolidation (P=0.004).
Age range (<65 years) (OR, 1.46) and female sex (OR, 1.40) were independent risk factors for long-term viral shedding. Early antiviral treatment should be considered for COVID-19 patients with such risk factors. |
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Anjum, FR, Anam, et al |
Viral Immunol |
Review Literature| Revue de littérature |
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Asselah, T, Durantel, et al |
Journal of hepatology |
Review Literature| Revue de littérature |
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Barriers and Enablers in Implementing Electronic Consultations in Primary Care: Scoping Review |
Baines, R, Tredinnick-Rowe, et al |
J Med Internet Res |
Review Literature| Revue de littérature |
ScR: 5 electronic databases (PubMed, Medline, Embase, CINAHL, and PsycINFO) were systematically searched for studies
published in 2009-2019. This review highlights the need for proactive engagement with patients and staff to facilitate understanding and awareness, process optimization, and delivery of coherent training and education that maximizes impact and success. Although
the necessity to use online methods during the COVID-19 pandemic may have accelerated awareness, concerns over workload duplication and inequality of access may remain. |
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Balagholi, S, Dabbaghi, et al |
Transfusion and Apheresis Science |
Review Literature| Revue de littérature |
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The hematology laboratory's response to the COVID-19 pandemic: A scoping review |
Bell, R, Zini, et al |
Int J Lab Hematol |
Review Literature| Revue de littérature |
ScR: comprehensive search of the literature published between December 1, 2019, and July 3, 2020. |
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Traumatic Stress in Healthcare Workers During COVID-19 Pandemic: A Review of the Immediate Impact |
Benfante, A, Di Tella, et al |
Frontiers in Psychology |
Review Literature| Revue de littérature |
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Pediatric lung function testing during a pandemic: An international perspective |
Beydon, N, Gochicoa, et al |
Paediatric Respiratory Reviews |
Review Literature| Revue de littérature |
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Cardiovascular Disease and SARS-CoV-2: the Role of Host Immune Response Versus Direct Viral Injury |
Biscetti, F, Rando, et al |
International journal of molecular sciences |
Review Literature| Revue de littérature |
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COVID-19 in pregnancy and the puerperium: A review for emergency physicians |
Boushra, MN, Koyfman, et al |
American Journal of Emergency Medicine |
Review Literature| Revue de littérature |
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Camostat Mesylate against SARS-CoV-2 and COVID-19 - Rationale, Dosing and Safety |
Breining, P, Frølund, et al |
Basic Clin Pharmacol Toxicol |
Review Literature| Revue de littérature |
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Brooke, BD, Raman, et al |
South African Medical Journal |
Review Literature| Revue de littérature |
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Bukkitgar, SD, Shetti, et al |
Chemical Engineering Journal |
Review Literature| Revue de littérature |
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Bustos, BR, Jaramillo-Bustamante, et al |
Pediatr Emerg Care |
Review Literature| Revue de littérature |
SR: systematic quantitative review, we analyzed 11 studies of PIMS-TS, including 468 children reported before July
1, 2020. Most patients received immunoglobulin or steroids, although the level of evidence for that treatment is low. The PIMS-ST was recently described, and the detailed quantitative pooled data will increase clinicians' awareness, improve diagnosis, and
promptly start treatment. |
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Chen, S, Pan, et al |
Curr Neurovasc Res |
Review Literature| Revue de littérature |
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Chetty, T, Daniels, et al |
South African Medical Journal |
Review Literature| Revue de littérature |
Rapid Review:A rapid evidence review was conducted, systematically searching PubMed and Google Scholar and grey literature
on 27 March 2020. There is insufficient evidence to support entry and exit screening at points of entry, as these strategies detect just over half of the infected cases, missing almost half at entry points. The benefits of airport screening therefore need
to be context specific and weighed against the resources and cost of implementation, the contribution of imported cases to total cases, and the benefits of identifying 50% of cases in the South African context with the country’s high HIV and tuberculosis prevalence
and limited resources to deal with a pandemic of this nature. |
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Biochemical biomarkers alterations in Coronavirus Disease 2019 (COVID-19) |
Ciaccio, M, Agnello, et al |
Diagnosis (Berl) |
Review Literature| Revue de littérature |
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Is highly expressed ACE 2 in pregnant women “a curse” in times of COVID-19 pandemic? |
Dhaundiyal, A, Kumari, et al |
Life Sciences |
Review Literature| Revue de littérature |
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Farham, B |
South African Journal of Science |
Review Literature| Revue de littérature |
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Universal Health Coverage and COVID-19 Pandemic: A Bangladesh Perspective |
Ferdous, Most Zannatul, Islam, et al |
medRxiv |
Review Literature| Revue de littérature |
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Ghasemnejad-Berenji, M, Pashapour, et al |
Drug Res (Stuttg) |
Review Literature| Revue de littérature |
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Guerrero, JuanI, Barragán, et al |
Research Square prepub |
Review Literature| Revue de littérature |
SR: comprehensive systematic review of all the original studies reporting patients with neurological involvement by
COVID-19, from December 2019 to June 2020. Our evidence synthesis led to a categorical analysis of the central and peripheral involvement by COVID-19 and provided a comprehensive explanation of the reported pathophysiological mechanisms by which SARS-CoV-2
infection may cause neurological impairment. |
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Orofacial manifestations of COVID-19: a brief review of the published literature |
Halboub, E, Al-Maweri, et al |
Brazilian oral research |
Review Literature| Revue de littérature |
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He, R, Zhang, et al |
International Journal of Environmental Research and Public Health |
Review Literature| Revue de littérature |
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Ji, B, Zhao, et al |
Chemical Engineering Journal |
Review Literature| Revue de littérature |
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Katzenschlager, Stephan, Zimmer, et al |
medRxiv |
Review Literature| Revue de littérature |
SR-MA: searched multiple databases (PubMed, Web of Science Core Collection, MedRvix and bioRvix) for publications from
December 2019 to May 31st 2020. This comprehensive meta-analysis found age, cerebrovascular disease, CRP, LDH and cTnI to be the most important risk-factors in predicting severe COVID-19 outcomes and will inform decision analytical tools to support clinical
decision-making. |
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Kenmoe, S, Kengne-Nde, et al |
PLoS One |
Review Literature| Revue de littérature |
SR-MA: performed an electronic search through Pubmed and Global Index Medicus databases. The present study has shown
that HRSV is the main cause of bronchiolitis in children, we also have Rhinovirus, and Bocavirus which also play a significant role. Data on the role played by SARS-CoV-2 in children with acute bronchiolitis is needed. |
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Kühlmeyer, K, Kuhn, et al |
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz |
Review Literature| Revue de littérature |
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Essential medicine selection during the COVID-19 pandemic: Enabling access in uncharted territory |
Leong, TD, McGee, et al |
South African Medical Journal |
Review Literature| Revue de littérature |
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Liu, K, Xu, et al |
American Journal of Translational Research |
Review Literature| Revue de littérature |
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Love, PED, Ika, et al |
Research in Transportation Economics |
Review Literature| Revue de littérature |
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Marciniak, MA, Shanahan, et al |
JMIR Mhealth Uhealth |
Review Literature| Revue de littérature |
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Marin, T, Maxel, et al |
Explore |
Review Literature| Revue de littérature |
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Characterising COVID-19 as a Viral Clotting Fever:
A Mixed-Methods Scoping Review |
Marley, JustinC, Marley, et al |
medRxiv |
Review Literature| Revue de littérature |
ScR:We conclude that COVID-19 leads to the syndrome of a viral clotting fever in a subgroup of patients and that the
presentation of coagulopathy and fever should raise the possibility of COVID-19 as a differential. |
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The novel zoonotic Coronavirus disease 2019 (COVID-19) pandemic: Health perspective on the outbreak |
Mazinani, M, Rude, et al |
Journal of Healthcare Quality Research |
Review Literature| Revue de littérature |
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Miranda, RR, Lopes, et al |
Brazilian oral research |
Review Literature| Revue de littérature |
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Sex differences in COVID-19: the role of androgens in disease severity and progression |
Mohamed, MS, Moulin, et al |
Endocrine |
Review Literature| Revue de littérature |
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Naderi-Azad, S, Vender, et al |
J Cutan Med Surg |
Review Literature| Revue de littérature |
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Union is strength: antiviral and anti-inflammatory drugs for COVID-19 |
Naveja, JJ, Madariaga-Mazón, et al |
Drug discovery today |
Review Literature| Revue de littérature |
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Nawsherwan, Khan, S, et al |
Iranian Journal of Public Health |
Review Literature| Revue de littérature |
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Noor, NM, Pett, et al |
F1000Research |
Review Literature| Revue de littérature |
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Oscanoa, TJ, Vidal, et al |
International journal of antimicrobial agents |
Review Literature| Revue de littérature |
MA: Data Sources PubMed, EMBASE, Google Scholar, the Cochrane Database of Systematic Reviews and preprint servers (medRxiv,
Research Square) were searched for studies published between December 2019 and June 30, 2020. Methods Effect statistics were pooled using random effects. Outcomes Critical LQT was defined as: (1) maximum QT corrected (QTc)≥500 ms (if QRS60 years were at highest
risk of HCQ-associated LQT (P60 years and/or taking other QT-prolonging drugs. |
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Ramos, CHI, Ayinde, et al |
Curr Protein Pept Sci |
Review Literature| Revue de littérature |
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Pulmonary Endothelial Dysfunction and Thrombotic Complications in COVID-19 Patients |
Rodríguez, C, Luque, et al |
Am J Respir Cell Mol Biol |
Review Literature| Revue de littérature |
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A systematic review of mask disinfection and reuse
for SARS-CoV-2 |
Rothe, Miguel, Rohm, et al |
medRxiv |
Review Literature| Revue de littérature |
SR: we describe results from 58 mask disinfection and reuse studies, where the majority of data were collected using
N95 masks. |
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Rubio Herrera, MA, Bretón Lesmes, et al |
Endocrinologia, Diabetes y Nutricion |
Review Literature| Revue de littérature |
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Environmental Disinfection of a Dental Clinic during the Covid-19 Pandemic: A Narrative Insight |
Scarano, A, Inchingolo, et al |
BioMed research international |
Review Literature| Revue de littérature |
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Neurological manifestation
and treatment strategies of COVID-19: A review |
Shreeja, D, Arpita, et al |
Research Journal of Biotechnology |
Review Literature| Revue de littérature |
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Splanchnic vein thrombosis in COVID-19: A review of literature |
Singh, B, Kaur, et al |
Digestive and Liver Disease |
Review Literature| Revue de littérature |
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Identification and analysis of ongoing registered clinical intervention trials on COVID-19 |
Solano-Sandí, LA, Cambronero-Valverde, et al |
Medwave |
Review Literature| Revue de littérature |
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A review of COVID-19 vaccines and major considerations for diabetic patients |
Soltani, S, Zandi, et al |
Biotechnol Appl Biochem |
Review Literature| Revue de littérature |
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Study on multiple aspects
of the newly emerged novel SARS-COV-2 and its pandemic disease Covid-19 |
Suryansh, R, Swati, et al |
Research Journal of Biotechnology |
Review Literature| Revue de littérature |
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Yim, RM, Singh, et al |
Dermatology online journal |
Review Literature| Revue de littérature |
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Convalescent plasma in the
treatment of severe covid-19: A systematic review and meta-analysis |
Zhang, X, Xi, et al |
Iranian Journal of Public Health |
Review Literature| Revue de littérature |
SR-MA: PubMed, Embase, Ovid, China Knowledge Network, China Biomedical, VIP Chinese Sci-tech Journal, Wanfang Database,
and the International Clinical Trials Registry Platform were searched up to 21 June 2020. Convalescent plasma therapy seems to yield some efficacy among patients with severe COVID-19 and almost no obvious adverse reactions were found. |
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Abdoli, A |
J Matern Fetal Neonatal Med |
Commentary/Editorial| Commentaire/Éditorial |
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Abdullah, AT, Hassen, et al |
OMICS |
Commentary/Editorial| Commentaire/Éditorial |
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Acevedo-Peña, J, Yomayusa-González, et al |
Revista Colombiana de Cardiologia |
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Ahmad, N, Eltawel, et al |
J Pediatr Hematol Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Has "conservative orthopaedics" re-emerged as a new branch in the COVID-19 pandemic? |
Ali, N, Kawoosa, et al |
Current Orthopaedic Practice |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and Saudi Arabia public financing of prescription drugs: An opportunity for reform |
AlRuthia, Y, Alrashed, et al |
Health Policy and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Althouse, BM, Wenger, et al |
PLoS Biol |
Commentary/Editorial| Commentaire/Éditorial |
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Reminder: Cardiovascular Patients Also Benefit from Influenza Vaccine |
Alves, M, Froes, et al |
Acta Medica Portuguesa |
Commentary/Editorial| Commentaire/Éditorial |
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Arantes, MF, Rodrigues, et al |
Clinics (Sao Paulo, Brazil) |
Commentary/Editorial| Commentaire/Éditorial |
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Armour, C, McGlinchey, et al |
Journal of Psychopathology and Behavioral Assessment |
Commentary/Editorial| Commentaire/Éditorial |
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Asayama, S, Emori, et al |
Sustainability Science |
Commentary/Editorial| Commentaire/Éditorial |
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Burn Unit admission and management protocol during COVID-19 pandemic |
Azzena, B, Perozzo, et al |
Burns |
Commentary/Editorial| Commentaire/Éditorial |
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Dreaming of immersive interactions to navigate forced distributed collaboration during Covid-19 |
Baklrlloglu, Y, Ramírez Galleguillos, et al |
Interactions |
Commentary/Editorial| Commentaire/Éditorial |
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Baldassarre, LA, Yang, et al |
J Natl Cancer Inst |
Commentary/Editorial| Commentaire/Éditorial |
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Bringing research directly to families in the era of COVID-19 |
Balevic, SJ, Singler, et al |
Pediatr Res |
Commentary/Editorial| Commentaire/Éditorial |
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Bara, GA, Maciaczyk, et al |
Neuromodulation |
Commentary/Editorial| Commentaire/Éditorial |
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Baron, M, Sherwen, et al |
Br J Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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Barros, N, Sharfuddin, et al |
Clin Transplant |
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Bergonti, M |
Eur Heart J |
Commentary/Editorial| Commentaire/Éditorial |
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An Executive Strategy to Support Long-Term Clinician Engagement Amid the COVID-19 Pandemic |
Berkow, S, Virkstis, et al |
J Nurs Adm |
Commentary/Editorial| Commentaire/Éditorial |
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Time to Stop the Tragedy in Spanish Nursing Homes during the COVID-19 Pandemi |
Bernabeu-Wittel, M, Gómez-Huelgas, et al |
J Am Geriatr Soc |
Commentary/Editorial| Commentaire/Éditorial |
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Graduate Medical Education Virtual Interviews and Recruitment in the Era of COVID-19 |
Bernstein, SA, Gu, et al |
Journal of graduate medical education |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in the United States: Where are we now? Where have we been? |
Bloomgarden, Z |
J Diabetes |
Commentary/Editorial| Commentaire/Éditorial |
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Spirituality and health in pandemic times: Lessons from the ancient wisdom |
Boas, AV |
Religions |
Commentary/Editorial| Commentaire/Éditorial |
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Botros, M, Cooper, et al |
Journal of graduate medical education |
Commentary/Editorial| Commentaire/Éditorial |
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The urgent need for research coordination to advance knowledge on COVID-19 in children |
Bourgeois, FT, Avillach, et al |
Pediatr Res |
Commentary/Editorial| Commentaire/Éditorial |
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Bright, A, Glynn-Robinson, et al |
Communicable diseases intelligence (2018) |
Commentary/Editorial| Commentaire/Éditorial |
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Underlying characteristics of the entities that make up the Colombian health system |
Buitrago-Mejía, A, Rodríguez-Barrero, et al |
Revista Venezolana de Gerencia |
Commentary/Editorial| Commentaire/Éditorial |
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Russia announces positive COVID-vaccine results from controversial trial |
Callaway, E |
Nature |
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Campos, MR, Schramm, et al |
Cadernos de saude publica |
Commentary/Editorial| Commentaire/Éditorial |
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Carmo Gomes, M, Nunes, et al |
Acta Medica Portuguesa |
Commentary/Editorial| Commentaire/Éditorial |
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In fatal COVID-19, the immune response can control the virus but kill the patient |
Casadevall, A, Pirofski, et al |
Proc Natl Acad Sci U S A |
Commentary/Editorial| Commentaire/Éditorial |
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Castiel, LD |
Salud colectiva |
Commentary/Editorial| Commentaire/Éditorial |
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Chagas, AL, Fonseca, et al |
Clinics (Sao Paulo, Brazil) |
Commentary/Editorial| Commentaire/Éditorial |
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The impact of COVID-19 on an early intervention in psychosis service |
Chakraborty, N, Carr, et al |
Progress in neurology and psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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ASPEN President's Address: "The 2020 Overture: A New Tune For the Future" |
Chan, LN |
JPEN J Parenter Enteral Nutr |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Associated Coagulopathy and Implications for its Treatment |
Cherneva, Z, Cherneva, et al |
Acta Medica Bulgarica |
Commentary/Editorial| Commentaire/Éditorial |
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Effect of the COVID-19 Pandemic on College Students With Disabilities |
Chugani, CD, Houtrow, et al |
Am J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Ciurea, A, Finckh, et al |
Ann Rheum Dis |
Commentary/Editorial| Commentaire/Éditorial |
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A case of newly diagnosed immune thrombocytopenia in the COVID-19 era |
Clerici, B, Birocchi, et al |
Intern Emerg Med |
Commentary/Editorial| Commentaire/Éditorial |
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Corpus-Mendoza, A, Ruiz-Segoviano, et al |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
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Coutard, B, Romette, et al |
Biopreserv Biobank |
Commentary/Editorial| Commentaire/Éditorial |
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Davids, EL |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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de Souza, TA, Silva, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 and EU competition law: Bring the informal guidance on |
de Stefano, G |
Journal of European Competition Law and Practice |
Commentary/Editorial| Commentaire/Éditorial |
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dos Santos, BP, de Gouveia, et al |
Forensic Toxicology |
Commentary/Editorial| Commentaire/Éditorial |
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Supporting survivors of sexual violence and abuse during the COVID-19 pandemic |
Dosdale, C, Skarparis, et al |
Br J Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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Doukakis, S, Alexopoulos, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Guarding Against Seven Common Threats to the Credible Estimation of COVID-19 Policy Effects |
Drabo, EF, Kang, et al |
Am J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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[Home confinement for COVID-19 and weight gain in schoolchildren and adolescents] |
Durá-Travé, T |
Nutr Hosp |
Commentary/Editorial| Commentaire/Éditorial |
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"Do I Have to Be Tested?": Understanding Reluctance to Be Screened for COVID-19 |
Egelko, A, Arnaout, et al |
Am J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Dr. Li Wenliang, COVID-19 outbreak and the principle
of beneficence |
Enriquez, PA, Lemus-Delgado, et al |
Veritas |
Commentary/Editorial| Commentaire/Éditorial |
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Fadeev, A, Larichkin, et al |
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Ferguson, C, Araújo, et al |
Nucleic Acids Res |
Commentary/Editorial| Commentaire/Éditorial |
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Association of the COVID-19 Outbreak With Patient Willingness to Enroll in Cancer Clinical Trials |
Fleury, ME, Farner, et al |
JAMA Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Forni, R, Besana, et al |
Swiss Med Wkly |
Commentary/Editorial| Commentaire/Éditorial |
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Editorial: The COVID-19 Pandemic is an Accelerator of the Evolution of Physiatry |
Francisco, GE |
Am J Phys Med Rehabil |
Commentary/Editorial| Commentaire/Éditorial |
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Reshaping cardiology amidst COVID-19: prioritizing medical education |
Fulton-Ward, T, Rallis, et al |
Eur Heart J Qual Care Clin Outcomes |
Commentary/Editorial| Commentaire/Éditorial |
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Learning From the US COVID-19 Response Toward Creating a Healthier Country |
Galea, S, Ettman, et al |
Am J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Gelfand, JM, Hefele, et al |
Journal of Investigative Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
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The Impact of the COVID-19 Pandemic on the 2019-2020 Job Search for Newly Trained Pathologists |
George, MR, Johnson, et al |
Arch Pathol Lab Med |
Commentary/Editorial| Commentaire/Éditorial |
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Ghahestani, SM, Bonakdar Hashemi, et al |
Urology journal |
Commentary/Editorial| Commentaire/Éditorial |
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Giordano, A, Forasassi, et al |
Minerva Chir |
Commentary/Editorial| Commentaire/Éditorial |
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Creative learning in digital and virtual environments
during COVID-19 and beyond |
Glăveanu, VP, Beghetto, et al |
Creative Learning in Digital and Virtual Environments: Opportunities and Challenges of Technology-Enabled Learning and Creativity |
Commentary/Editorial| Commentaire/Éditorial |
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Glăveanu, VP, Ness, et al |
Creative Learning in Digital and Virtual Environments: Opportunities and Challenges of Technology-Enabled Learning and Creativity |
Commentary/Editorial| Commentaire/Éditorial |
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Lesson for the clinical nephrologist: Kidney transplant, COVID-19 and pregnancy |
Gleeson, S, Noori, et al |
J Nephrol |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and consent for research: Navigating during a global pandemic |
Goldman, RD, Gelinas, et al |
Clinical Ethics |
Commentary/Editorial| Commentaire/Éditorial |
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Gómez Franco, T, Matarín Rodríguez-Peral, et al |
Salud colectiva |
Commentary/Editorial| Commentaire/Éditorial |
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Lung cancer control in the UK hit badly by COVID-19 pandemic |
Gourd, Elizabeth |
The Lancet Oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Granados Maguiño, MA, Romero Vela, et al |
Revista Venezolana de Gerencia |
Commentary/Editorial| Commentaire/Éditorial |
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Granic, I, Morita, et al |
Psychological Inquiry |
Commentary/Editorial| Commentaire/Éditorial |
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Gray-Miceli, D, Bouchaud, et al |
Geriatric nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Griffiths, Charmaine, Mitchell, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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The impact of Covid-19 on liquidity of emerging market bonds |
Gubareva, M |
Finance Research Letters |
Commentary/Editorial| Commentaire/Éditorial |
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Chikungunya fever and COVID-19: oral ulcers are a common feature |
Gueiros, LA, Neves, et al |
Oral Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Reimagining Residency Selection: Part 1-A Practical Guide to Recruitment in the Post-COVID-19 Era |
Haas, MRC, He, et al |
Journal of graduate medical education |
Commentary/Editorial| Commentaire/Éditorial |
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"Essential" but Expendable: Farmworkers During the COVID-19 Pandemic-The Michigan Farmworker Project |
Handal, AJ, Iglesias-Ríos, et al |
Am J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Hasle, G |
Tidsskr Nor Laegeforen |
Commentary/Editorial| Commentaire/Éditorial |
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Henderson, J |
Health Inf Manag |
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Hipkiss, A |
Kai Tiaki Nursing New Zealand |
Commentary/Editorial| Commentaire/Éditorial |
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Hipólito, J, Diele-Viegas, et al |
Anais da Academia Brasileira de Ciencias |
Commentary/Editorial| Commentaire/Éditorial |
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Minding the gap: Compassionate
maai, social relating and communicating within re-constructed space |
Hiskey, S, Clapton, et al |
Clinical Psychology Forum |
Commentary/Editorial| Commentaire/Éditorial |
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Hodžić, A, de la Fuente, et al |
ACS Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Holland, DE, Vanderboom, et al |
Prof Case Manag |
Commentary/Editorial| Commentaire/Éditorial |
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Horton, Richard |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Iacobaeus, E, Burman, et al |
Lakartidningen |
Commentary/Editorial| Commentaire/Éditorial |
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SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19 |
Johnson, HM, Lewin, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Karakasi, MV, Kevrekidis, et al |
Am J Forensic Med Pathol |
Commentary/Editorial| Commentaire/Éditorial |
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Challenges in Testing for SARS-CoV-2 Among Patients Who Recovered From COVID-19 |
Katz, MH |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Khan, MA, Younus, et al |
Curr Pharm Biotechnol |
Commentary/Editorial| Commentaire/Éditorial |
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Kim, YJ, Qian, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Kleinman, MB, Felton, et al |
Journal of substance abuse treatment |
Commentary/Editorial| Commentaire/Éditorial |
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Kofler, W, Glazachev, et al |
Scand J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Nothing much has changed: COVID-19 nursing home cases and deaths follow fall surges |
Konetzka, RT, Gorges, et al |
J Am Geriatr Soc |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: Way Forward With Serosurveillance Without Overemphasizing Neutralizing Antibodies |
Krsak, M, Henao-Martínez, et al |
Viral Immunol |
Commentary/Editorial| Commentaire/Éditorial |
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Larsen, LL, Hellfritzsch, et al |
Ugeskrift for laeger |
Commentary/Editorial| Commentaire/Éditorial |
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Lawson, SA |
Rural Theology |
Commentary/Editorial| Commentaire/Éditorial |
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Virtual Cancer Care During the COVID-19 Pandemic and Beyond: A Call for Evaluation |
Levine, OH, McGillian, et al |
JMIR Cancer |
Commentary/Editorial| Commentaire/Éditorial |
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Vascular injury in acute infections and COVID-19: everything old is new again |
Levy, JH, Iba, et al |
Trends in cardiovascular medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Li, Y, Wu, et al |
Current problems in cancer |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Infection Risk Among Hemodialysis Patients in Long-term Care Facilities |
Liu, CK, Ghai, et al |
Kidney Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Elective Surgery and COVID-19: A Framework for the Untested Patient |
Lu, AC, Burgart, et al |
Ann Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Establishing a New Normal for Hospital Care: A Whole of Hospital Approach to COVID-19 |
Lum, BX, Liu, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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MacLaren, G, Combes, et al |
Intensive Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Maguire, SM |
Planning |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: FDA authorises neutralising antibody bamlanivimab for non-admitted patients |
Mahase, E |
BMJ |
Commentary/Editorial| Commentaire/Éditorial |
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Maness, SB, Merrell, et al |
Public Health Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Marone, E, Bohle, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Problems of interpreting diagnostic tests for SARS-CoV-2: Analytical chemistry concerns |
Mattioli, IA, Crespilho, et al |
Anais da Academia Brasileira de Ciencias |
Commentary/Editorial| Commentaire/Éditorial |
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McKenna, G, Janssens, et al |
Gerodontology |
Commentary/Editorial| Commentaire/Éditorial |
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McQuoid-Mason, D |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Corona Pandemic and Stock Market Behaviour: Empirical Insights from Selected Asian Countries |
Mishra, PK, Mishra, et al |
Millennial Asia |
Commentary/Editorial| Commentaire/Éditorial |
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IoMT amid COVID-19 pandemic: Application, architecture, technology, and security |
Mohd Aman, AH, Hassan, et al |
Journal of Network and Computer Applications |
Commentary/Editorial| Commentaire/Éditorial |
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Moodley, K |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Action needed now to prevent further increases in measles and measles deaths in the coming years |
Mulholland, Kim, Kretsinger, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Murphy, MF, Dzik, et al |
Blood |
Commentary/Editorial| Commentaire/Éditorial |
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Repurposing Video Review Infrastructure for Clinical Resuscitation Care in the Age of COVID-19 |
Myers, SR, Abbadessa, et al |
Annals of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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N, SS, Mondal, et al |
Future Microbiol |
Commentary/Editorial| Commentaire/Éditorial |
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Nam, HY, Hernandez, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Namasivayam-MacDonald, A, Riquelme, et al |
Am J Speech Lang Pathol |
Commentary/Editorial| Commentaire/Éditorial |
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Nicolaides, P |
Journal of European Competition Law and Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Nimmo, Camus, Agbetile, et al |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Roles for mHealth to support Community Health Workers addressing COVID-19 |
O'Donovan, J, Hamala, et al |
Glob Health Promot |
Commentary/Editorial| Commentaire/Éditorial |
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Ojha, A |
Journal of Ethnic and Cultural Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Update from the Advisory Committee on Immunization Practices |
O'Leary, ST, Maldonado, et al |
J Pediatric Infect Dis Soc |
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Omeogu, C, Green-McKenzie, et al |
J Occup Environ Med |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 school closure and adolescent mental health in sub-Saharan Africa |
Oppong Asante, K, Quarshie, et al |
Int J Soc Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Orscheln, RC, Newland, et al |
Journal of Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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Papaefstathiou, E, Apostolopoulou, et al |
Urology journal |
Commentary/Editorial| Commentaire/Éditorial |
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Partinen, M, Bjorvatn, et al |
J Sleep Res |
Commentary/Editorial| Commentaire/Éditorial |
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Peiffer-Smadja, Nathan, Yazdanpanah, et al |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Perondi, B, Miethke-Morais, et al |
Brazilian Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Peters, MA |
Pandemic Education and Viral Politics |
Commentary/Editorial| Commentaire/Éditorial |
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Peters, MA |
Pandemic Education and Viral Politics |
Commentary/Editorial| Commentaire/Éditorial |
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Peters, MA, Besley, et al |
Pandemic Education and Viral Politics |
Commentary/Editorial| Commentaire/Éditorial |
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Achieving American Nurses Credentialing Center Magnet® Designation With a Virtual Site Visit |
Phan, R, Radovich, et al |
J Nurs Adm |
Commentary/Editorial| Commentaire/Éditorial |
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TRANSMISIÓN PERINATAL DE SARS-COV-2: NECESIDAD DE ESTUDIO ANTE POSIBLE INFECCIÓN CONGÉNITA |
PhD, OLR, Md, et al |
Revista colombiana de obstetricia y ginecologia |
Commentary/Editorial| Commentaire/Éditorial |
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Optimal governance and implementation of vaccination programs to contain the COVID-19 pandemic |
Piraveenan, Mahendra, Sawleshwarkar, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Preiser, W, Preiser, et al |
South African Journal of Science |
Commentary/Editorial| Commentaire/Éditorial |
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HIV and SARS-CoV-2: points to consider to face this new pandemic |
Prieto Pozo, AA, Salvador Sagüez, et al |
Medwave |
Commentary/Editorial| Commentaire/Éditorial |
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Safety of Surgical Telehealth in the Outpatient and Inpatient Setting |
Purnell, S, Zheng, et al |
Surgical Clinics of North America |
Commentary/Editorial| Commentaire/Éditorial |
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Rallis, KS, Allen-Tejerina, et al |
Trends in Cancer |
Commentary/Editorial| Commentaire/Éditorial |
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Reinders, C |
Pharmaceutisch weekblad |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: NHS staff express scepticism over promised twice weekly testing |
Rimmer, A |
BMJ |
Commentary/Editorial| Commentaire/Éditorial |
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Rizzuti, S, De Napoli, et al |
International Journal on Interactive Design and Manufacturing |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in People with Diabetes: Perspectives from Saudi Arabia |
Robert, AA, Al Dawish, et al |
Curr Diabetes Rev |
Commentary/Editorial| Commentaire/Éditorial |
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Rosen, D |
American Journal of Geriatric Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Ruyssen-Witrand, A, Soubrier, et al |
Ann Rheum Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Sadarangani, TR |
Geriatric nursing |
Commentary/Editorial| Commentaire/Éditorial |
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READ-COGvid: A Database From Reading and Media Habits During COVID-19 Confinement in Spain and Italy |
Salmerón, L, Arfé, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Santana, FN, Fischer, et al |
Environmental Research Letters |
Commentary/Editorial| Commentaire/Éditorial |
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Learning From COVID-19: Prevention Is a Strategic Principle, Not an Option |
Saracci, R |
Am J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Schoch-Spana, M, Brunson, et al |
Vaccine |
Commentary/Editorial| Commentaire/Éditorial |
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Seymour, CW, Bauchner, et al |
JAMA |
Commentary/Editorial| Commentaire/Éditorial |
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Suicide research and prevention during and after the COVID-19 pandemic |
Sher, L |
Acta Psychiatrica Scandinavica |
Commentary/Editorial| Commentaire/Éditorial |
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Shrikhande, SV, Chaudhary, et al |
Indian Journal of Surgical Oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Silverman, M, Clarke, et al |
Am J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Smith, EmilyR, He, et al |
medRxiv |
Commentary/Editorial| Commentaire/Éditorial |
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Sridhar, Devi |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of COVID-19 pandemic on ophthalmology service provisions and training |
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Commentary/Editorial| Commentaire/Éditorial |
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Reimagining Residency Selection: Part 2-A Practical Guide to Interviewing in the Post-COVID-19 Era |
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Commentary/Editorial| Commentaire/Éditorial |
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Subbaraman, N |
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Commentary/Editorial| Commentaire/Éditorial |
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Sullivan, CE |
Sleep and Biological Rhythms |
Commentary/Editorial| Commentaire/Éditorial |
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Commentary/Editorial| Commentaire/Éditorial |
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Sulzgruber, P, Krammel, et al |
ESC Heart Fail |
Commentary/Editorial| Commentaire/Éditorial |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.*
Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.
Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers.
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Séquelles à long terme:
Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.
Santé mentale:
Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées
à la pandémie.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives