Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-11-12
Good afternoon,
There are 487 citations in today’s scan. 270 were considered primary research or review literature.
Highlights today include:
CANADA
·
Rotshenker-Olshinka et al. A retrospective cohort study conducted at a university-affiliated fertility center in Montreal, Quebec, since the COVID-19
shut down, March 13 until May 6, 2020. This study aims to evaluate the effect of the COVID-19 pandemic state on early, first-trimester pregnancies. The COVID-19 pandemic environment does not seem to affect early first-trimester miscarriage rates in asymptomatic
patients.
PUBLIC HEALTH INTERVENTION
·
Peng et al performed extensive simulations to evaluate the performance of quarantine strategies with one or more tests administered during quarantine in order to assess
a test result based quarantine period. They found that SARS-CoV-2 testing can effectively reduce the length of quarantine without compromising personal or public safety. Whereas a single RT-PCR test performed before the end of quarantine can reduce the duration
of quarantine to 10 days, two tests can further reduce the duration to 8-days and three tests with a highly sensitive RT-PCR test can justify a 6-day quarantine.
IPAC
·
Sousan et al
assess the efficiency of the Halyard H600 as a respirator filtering material as compared to the NIOSH-certified N95 and P100 filters, and determine if H600 is a good alternative for respiratory protection for healthcare professionals during the COVID-19
pandemic. The high variability in filter efficiency for particles ≤324 nm and the increased fabric breathing resistance demonstrate that the Halyard H600 has an inferior performance and is not a good substitute for N95 and P100.
·
Steinhauer et al demonstrate that two commercially available formulations for surface disinfection and one formulation
for hand disinfection claiming “virucidal activity against enveloped viruses” are effectively inactivating SARS-CoV-2. This study emphasizes that chemical disinfectants claiming “virucidal activity against enveloped viruses” are an effective choice to target
enveloped SARS-CoV-2 as a preventive measure.
TRANSMISSION
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Placzek et al.,
determined that neonatal SARS-CoV2 infection was rare in the UK
·
Zhou and Ji
investigate the transport of droplet aerosols generated by both doctors and patients to seek measures to reduce the risk of infection. Their results show that purification of the same number of droplet aerosols and purification by ventilation work better
for coughing than for talking. The best ventilation performance appeared for the case of a patient sitting and coughing (PSC), while the case of a patient lying and talking (PLT) was the worst.
EPIDEMIOLOGY
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Selhorst et al. A case of re-infection was observed in a Belgian nosocomial outbreak involving 3 patients and 2 health care workers. The symptomatic re-infection
occurred after an interval of 185 days, despite the development of an effective humoral immune response following symptomatic primary infection. The second episode, however, was milder and characterized by a fast rise in serum IgG and neutralizing antibodies.
Although contact tracing and virus culture remained inconclusive, the health care worker formed a transmission cluster with 3 patients and showed evidence of virus replication but not of neutralizing antibodies in her nasopharyngeal swabs.
·
Peng et al identified the risk factors for redetectable positivity (RP), and to provide a basis for prevention and control of coronavirus disease‐2019 (COVID‐19) in children. Results
find that family cluster infection, higher WBC count, and longer PT are the early risk factors for RP in recovered COVID‐19 children. The dynamic changes in number and ratio of CD4+ and CD8+ T lymphocytes may be involved in prolonged SARS‐CoV‐2 clearance.
CLINICAL DATA
·
Hellman et al
demonstrated that the lungs of fatal Covid-19 contain hyaluronan, associated with inflammation and ARDS and may have the appearance of liquid jelly. Stainings confirmed that hyaluronan is obstructing alveoli with presence in exudate and plugs, as well
as in thickened perialveolar interstitium. In contrast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tissue.
·
Bussani et al analyzed 41 COVID-19 infected individuals post-mortem. COVID-19 is a unique interstitial pneumonia characterized by extensive lung thrombosis, long-term persistence
of viral RNA in pneumocytes and endothelial cells, along with the presence of infected cell syncytia. Several of COVID-19 features might be consequent to the persistence of virus-infected cells for the duration of the disease.
THERAPEUTICS
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Self et al. conducted an RCT at 34 hospitals in the US, investigates whether treatment with hydroxychloroquine improve clinical outcomes of adults hospitalized
with coronavirus disease 2019 (COVID-19). The distribution of the day 14 clinical status score was not significantly different for patients randomized to receive hydroxychloroquine compared with placebo. These findings do not support the use of hydroxychloroquine
for treatment of COVID-19 among hospitalized adults.
·
Dhibar et al. report on a clinical trial to evaluate the efficacy of hydroxychloroquine (HCQ) as post exposure prophylaxis (PEP) to prevent COVID-19 in asymptomatic,
high risk, household contacts of the laboratory confirmed COVID-19 cases. The study found that there was significant risk reduction for the incidence of COVID-19 in participants who received PEP with HCQ plus standard therapy, as compared to standard therapy
alone.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley
Otten, Irene Yong, Drew Greydanus, Shalane Ha, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark, Catherine Card, Ruey Su, Paul McLaren
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics /
Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance,
Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, Immunologie,
économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Resistance of endothelial cells to SARS-CoV-2 infection in vitro |
Ahmetaj-Shala, Blerina, Peacock, et al |
bioRxiv |
Coronavirology| Coronavirologie |
To determine infectibility of primary endothelial cell lines with live SARS-CoV-2 and pseudoviruses expressing SARS-CoV-2
spike protein. Expression of ACE2 and BSG pathways genes was determined in three types of endothelial cells; blood outgrowth, lung microvascular and aortic endothelial cells. For comparison nasal epithelial cells, Vero E6 cells and HEK 293T cells transfected
with either ACE2 or BSG were used as controls. Endothelial cells are resistant to infection with SARS-CoV-2 virus, in line with relatively low levels of ACE2 and TMPRSS2, suggesting that the vascular dysfunction and thrombosis seen in severe COVID-19 is a
result of factors released by adjacent infected cells (e.g. epithelial cells) and/or circulating, systemic inflammatory mediators. |
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GP-LVM of categorical data from test-positive COVID-19 pregnant women |
Ajirak, Marzieh, Heiselman, et al |
arXiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this paper, we model categorical variables of 89 test-positive COVID-19 pregnant women within the unsupervised Bayesian framework. We model the data
using latent Gaussian processes for density estimation of multivariate categorical data. The results show that the model can find latent patterns in the data, which in turn could provide additional insights into the study of pregnant women that are COVID-19
positive. |
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Ali, SM, Malik, et al |
Environ Res |
Epidemiology| Épidémiologie |
This paper focuses on how the particulate matter pollution was reduced during the lockdown period (23 March to 15 April 2020) as compared to before lockdown.
Both datasets have shown a substantial reduction in PM(2.5) pollution levels (ranging from 13 to 33% in case of satellite observations, while 23 to 58 % in ground-based observations) across Pakistan. Result shows a higher rate of COVID-19 spread in major cities
of Pakistan in cities of Pakistan with poor air quality conditions. Yet more research is needed in order to establish linkage between COVID-19 spread and air pollution. However, it can be partially attributed to both higher rate of population density and frequent
exposure of population to enhanced levels of PM(2.5) concentrations before lockdown period. |
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Correlation of chest radiography findings with the severity and progression
of COVID-19 pneumonia |
Al-Smadi, A, Bhatnagar, et al |
Clin Imaging |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Aim is to assess the temporal changes and prognostic value of chest radiograph (CXR) in COVID-19 patients. A retrospective study of 62 confirmed COVID-19
patients were evaluated for clinical features. 56 of these (total: 325 CXRs) were evaluated for radiological findings. Common patterns were progression from lower to upper zones, peripheral to diffuse involvement, & from ground glass opacities to consolidation.
Consolidations starting peripherally were noted in 76%, 93% and 48% with critical outcomes, respectively. The interobserver agreement of the CoV-P category of CXRs in the critical and non-critical outcome groups were good and excellent, respectively (τ coefficient
= 0.6 & 1.0). Significant association was observed between CoV-P2 and clinical deterioration into a critical status (χ2 = 27.7, p = 0.0001) with high sensitivity (95%) and specificity (71%) within a median interval time of 2 days (range: 0-4 days). Involvement
of predominantly 4 or more zones on frontal chest radiograph can be used as predictive prognostic indicator of poorer outcome in COVID-19 patients. |
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Alwaeli, Haidar, Shabbir, et al |
Research Square prepub |
Clinical data| Données cliniques |
This case series presents seven COVID-19 patients who have received anticoagulation therapy over the course of the disease. Additionally, the correlation
between thromboembolic complications secondary to COVID-19, prophylactic use of anticoagulation therapy and the significant pathological findings that might arise will be assessed and discussed in great details. |
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Amaral-Prado, H, Borghi, et al |
Int J Soc Psychiatry |
Mental Health | |
The aim of this study was to analyze and compare perceived stress, resilience, depression symptoms and coping strategies
on the members of University of Campinas, in Brazil, before and during the outbreak of the COVID-19. We obtained 1,135 responses (893 before COVID-19 and 242 during COVID-19). The volunteers did not show significant differences for perceived stress, depressive
signs and resilience before and during the pandemic. In both periods, men exhibited lower scores for perceived stress and depression and higher scores for resilience when compared to women. Undergraduate and graduate students exhibited higher perceived stress
scores, more pronounced depressive signs and lower resilience, and employees and professors presented lower scores for perceived stress, depressive signs and greater resilience. |
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Amin, R, Grinblat, et al |
CMAJ |
Clinical data| Données cliniques |
A 58-year-old diabetic and morbidly obese (body mass index: 44.3 kg / m2) woman presented for an outpatient consultation
for the usual staging of her Hodgkin lymphoma who tested positive or COVID-19 |
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Bajaj, J, Solanki, et al |
Journal of Anaesthesiology Clinical Pharmacology |
Mental Health |
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This study attempts to highlight the risk factors and psychological impact on doctors who have tested positive for
COVID-19. This online cross-sectional survey-based study includes 51 doctors of all specialities of in Mumbai, India, who had tested positive for novel coronavirus. Most of them were (67%) postgraduate students. Forty-three (85%) respondents were working
in a COVID-19 center. Twenty-three (45%) had a history of contact with these patients without proper PPE with unknown COVID-19 status of the patient at the time of contact. Ten percent regretted their decision of becoming a doctor. Only half (51%) had family
support during their illness and 45% relied on friends and colleagues in the hospital. Twenty-six percent mentioned having a low mood throughout the illness. A major portion of people (32%) having fear of severe illness and death. |
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Banerjee, S, Kar, et al |
Phytochem Anal |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In India, AYUSH systems of medicine have been promoted as an immune-protection strategy. Andrographis paniculata (Burm.
F) Nees (AP) mentioned in Ayurveda has been widely used for treating sore throat, flu, and upper respiratory tract infections which may provide possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways. The molecules from kalmegh
provides immune-protection and anti-viral response via involving different pathways, like toll-like receptor pathway, PI3/AKT pathway and MAP kinase pathways against COVID-19 infection. The KEGG analysis showed that in a vast majority of the most enriched
pathways, AP were associated with viral infections and upper respiratory tract infections. The results suggest a synergy between andrographolide and other molecules identified as safe and efficacious anti-inflammatory agent having effects on upper respiratory
tract infections and can significantly decrease the production of cytokines and pro-inflammatory factors in viral infections. |
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PMC7598751; Trust and compliance to public
health policies in times of COVID-19 |
Bargain, O, Aminjonov, et al |
J Public Econ |
Public Health response| Interventions de santé publique |
While degraded trust and cohesion within a country are often shown to have large socio-economic impacts, they can also
have dramatic consequences when compliance is required for collective survival. We illustrate this point in the context of the COVID-19 crisis. Policy responses all over the world aim to reduce social interaction and limit contagion. Using data on human mobility
and political trust at regional level in Europe, we examine whether the compliance to these containment policies depends on the level of trust in policy makers prior to the crisis. Using a double difference approach around the time of lockdown announcements,
we find that high-trust regions decrease their mobility related to non-necessary activities significantly more than low-trust regions. We also exploit country and time variation in treatment using the daily strictness of national policies. The efficiency of
policy stringency in terms of mobility reduction significantly increases with trust. The trust effect is nonlinear and increases with the degree of stringency. We assess how the impact of trust on mobility potentially translates in terms of mortality growth
rate. |
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Baunez, Christelle, Degoulet, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
An acceleration index is proposed as a novel indicator to track the dynamics of the COVID-19 iin real-time. Using French
data on confirmed cases and tests for the period following the first lock-down - from May 13, 2020, onwards - our acceleration index shows that the ongoing pandemic resurgence can be dated to begin around July 7. It uncovers the fact that the pandemic acceleration
has been stronger than national average for the 59 − 68] and 69 − 78] age groups since early September, the latter being associated with the strongest acceleration index, as of October 25. In contrast, acceleration among the 19 − 28] age group is the lowest
and is about half that of the 69 − 78], as of October 25. In addition, we propose an algorithm to allocate tests among French départements, based on both the acceleration of the pandemic and the feedback effect of testing. Our acceleration-based allocation
differs significantly from the actual distribution over French territories, which is population-based. We argue that both our acceleration index and our allocation algorithm are useful tools to guide public health policies as France enters a second lock-down
period with indeterminate duration. |
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Becker, MG, Taylor, et al |
PLoS One |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we provide support for the adoption of sample pooling with the point-of-care Cepheid Xpert® Xpress SARS-CoV-2
molecular assay. Corroborating previous findings, the limit of detection of this assay was comparable to laboratory-developed reverse-transcription quantitative PCR SARS-CoV-2 tests, with observed detection below 100 copies/mL. The Xpert® Xpress assay detected
SARS-CoV-2 after samples with minimum viral loads of 461 copies/mL were pooled in groups of six. Based on these data, we recommend the adoption of pooled testing with the Xpert® Xpress SARS-CoV-2 assay where warranted based on public health needs. The suggested
number of samples per pool, or the pooling depth, is unique for each point-of-care testing site and can be determined by the positive test rates. |
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Bharadwaz, A, Langfeldt, et al |
J Med Imaging Radiat Oncol |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The purpose of this article is to describe the morphological and distributional patterns of the lung opacities in CXR
and to classify the spectrum of essential features on portable AP chest radiographs of PCR-positive COVID-19 patients admitted in a tertiary care hospital in Scandinavia. A retrospective analysis of twenty (20) RT-PCR-positive COVID-19 patients admitted to
the hospital between 12.03.2020 to 10.04.2020 was done in this study. Most patients had ground-glass opacities (80-85%) and interspersed interstitial opacities (70-75%), often with a characteristic appearance. The opacities were mostly bilateral (80%) and
distributed in the lower zones (and to some extent mid zones) and in the middle and peripheral regions, with a tendency to merge towards the hilar areas. There were high interobserver agreements among various parameters and no significant statistical difference
between observer 1 and 2. |
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Binder, RA, Alarja, et al |
J Infect Dis |
Epidemiology| Épidémiologie Transmission |
During April and May 2020, we studied 20 patients hospitalized with coronavirus disease 2019 (COVID-19), their hospital
rooms (fomites and aerosols), and their close contacts for molecular and culture evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Among >400 samples, we found molecular evidence of virus in most sample types, especially the nasopharyngeal
(NP), saliva, and fecal samples, but the prevalence of molecular positivity among fomites and aerosols was low. The agreement between NP swab and saliva positivity was high (89.5%; κ = 0.79). Two NP swabs collected from patients on days 1 and 7 post-symptom
onset had evidence of infectious virus (2 passages over 14 days in Vero E6 cells). In summary, the low molecular prevalence and lack of viable SARS-CoV-2 virus in fomites and air samples implied low nosocomial risk of SARS-CoV-2 transmission through inanimate
objects or aerosols. |
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PMC7605746; Estimating the cumulative rate of SARS-CoV-2 infection |
Bollinger, CR, van Hasselt, et al |
Econ Lett |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Accurate estimates of the cumulative incidence of SARS-CoV-2 infection remain elusive. Among the reasons for this are
that tests for the virus are not randomly administered, and that the most commonly used tests can yield a substantial fraction of false negatives. In this article, we propose a simple and easy-to-use Bayesian model to estimate the infection rate, which is
only partially identified. The model is based on the mapping from the fraction of positive test results to the cumulative infection rate, which depends on two unknown quantities: the probability of a false negative test result and a measure of testing bias
towards the infected population. Accumulating evidence about SARS-CoV-2 can be incorporated into the model, which will lead to more precise inference about the infection rate. |
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Brazzelli, V, Isoletta, et al |
Dermatol Ther |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The impact of biologic drugs used in the treatment of psoriasis, do patients suffer from increased morbidity and mortality
from COVID-19, compared to psoriatic patients treated only with topical drugs? A total of 180 patients were enrolled in two groups: 100 patients in the topical therapy group, and 80 patients in the biologic therapy group. No statistically significant difference
was found between the groups regarding the prevalence of COVID-19 infection and symptoms at a bivariable analysis with adjustment for confounders. |
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Brown, SM, Peltan, et al |
Ann Am Thorac Soc |
Therapeutics| Thérapeutique RCT |
We performed a randomized clinical trial of hydroxychloroquine vs. azithromycin among hospitalized patients with COVID-19.
Treatment was 5 days of study medication. The primary endpoint was the COVID Ordinal Outcomes scale at day 14. The trial was stopped early after enrollment of 85 patients when a separate clinical trial concluded that a clinically important effect of hydroxychloroquine
over placebo was definitively excluded. Comparisons were made a priori using a proportional odds model from a Bayesian perspective. The estimated odds ratio for less favorable status on the ordinal scale for hydroxychloroquine vs. azithromycin from the primary
analysis was 1.07, with a 95% credible interval from 0.63 to 1.83 with a posterior probability of 60% that hydroxychloroquine was worse than azithryomycin. Secondary outcomes displayed a similar, slight preference for azithromycin over hydroxychloroquine.
The twenty safety outcomes were similar between arms with the possible exception of post-randomization onset acute kidney injury, which was more common with hydroxychloroquine (15% vs. 0%). Patients in the hydroxychloroquine arm received remdesivir more often
than in the azithromycin arm (19% vs. 2%). There was no apparent association between remdesivir use and acute kidney injury. While early termination limits the precision of our results, we found no suggestion of substantial efficacy for hydroxychloroquine
over azithromycin. Acute kidney injury may be more common with hydroxychloroquine than azithromycin, although this may be due to the play of chance. Differential use of remdesivir may have biased our results in favor of hydroxychloroquine. Our results are
consistent with conclusions from other trials that hydroxychloroquine cannot be recommended for inpatients with COVID-19; azithromycin may merit additional investigation. |
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Bussani, Rossana, Schneider, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques Coronavirology| Coronavirologie Immunology | Immunologie |
Post-mortem analyses of 41 COVID-19 infected individuals. Histological analysis is complemented by immunohistochemistry
for cellular and viral antigens and the detection of viral genomes by in situ RNA hybridization. COVID-19 is a unique interstitial pneumonia characterized by extensive lung thrombosis, long-term persistence of viral RNA in pneumocytes and endothelial cells,
along with the presence of infected cell syncytia. Several of COVID-19 features might be consequent to the persistence of virus-infected cells for the duration of the disease. |
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Butala, NM, Patel, et al |
Circ Cardiovasc Interv |
Healthcare Response | Réponse des soins de santé |
We quantified the impact of different STEMI treatment strategies on patient outcomes and provider risk in context of
the COVID-19 pandemic. Usual care with PPCI remains the appropriate treatment strategy in the majority of cases presenting with STEMI in the setting of the COVID-19 pandemic. However, utilization of a pharmaco-invasive strategy in selected patients with STEMI
with presumptive COVID-19 and low likelihood of mortality from STEMI and use of preventive strategies such as preprocedural intubation in high risk patients when PPCI is the preferred strategy may be reasonable to reduce provider risk of COVID-19 infection. |
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Evaluation of lifestyle, attitude and stressful impact amid COVID-19 among adults
in Shanghai, China |
Cao, Y, Ma, et al |
Int J Environ Health Res |
Mental Health |
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Although the COVID-19 pandemic was correlated with high stressful impact, it had associated with some positive mental-health
related changes in an urban environment. |
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Carubbi, Francesco, Salvati, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We conducted a retrospective evaluation of hospitalized patients in order to identify relationships between clinical,
serological, imaging data and disease outcomes in patients with COVID-19. We demonstrated that ferritin levels over the 25th percentile are associated with a more severe pulmonary involvement, independently of age and gender and not associated with disease
outcomes. |
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Systemic Capillary Leak Syndrome Secondary to Coronavirus Disease 2019 |
Case, R, Ramaniuk, et al |
Chest |
Clinical data| Données cliniques |
This is the first reported case of systemic capillary leak syndrome associated with COVID-19 infection. |
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Stigmatisation associated with COVID-19 in the general Colombian population |
Cassiani-Miranda, C, Campo-Arias, et al |
Int J Soc Psychiatry |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
The aim of this study was to determine the association between stigmatisation and fear of COVID-19 in the general population
of Colombia. Stigma-discrimination towards COVID-19 is frequent in the Colombian population and is associated with high levels of fear towards said disease, mainly people who are not health workers. |
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Ceylan, KC, Batihan, et al |
Eur J Cardiothorac Surg |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Our main goal was to describe a new drainage technique to prevent viral transmission during chest tube application
and follow-up. A high-efficiency particulate air filter mounted double-bottle technique was used to prevent viral transmission. |
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Real-time, interactive website for US-county-level COVID-19 event risk assessment |
Chande, A, Lee, et al |
Nat Hum Behav |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
To provide real-time, geolocalized risk information, we developed an interactive online dashboard that estimates the
risk that at least one individual with SARS-CoV-2 is present in gatherings of different sizes in the United States. |
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Che, Y, Liu, et al |
Clin Infect Dis |
Vaccine Research| Recherche sur les vaccins Immunology | Immunologie RCT |
We evaluated an inactivated SARS-CoV-2 vaccine for immunogenicity and safety in adults aged 18-59 years. Adults vaccinated
with inactivated SARS-CoV-2 vaccine had NAb as well as anti-S/N antibody, and had a low rate of adverse reactions. |
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Chen, J, Tan, et al |
Integr Med Res |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study was conducted to assess the efficacy and safety of Traditional Chinese Medicines containing modified Radix
Fici Simplicissimae in combination with the Western medicines in the treatment of SARS-CoV-2 patients which were confirmed in Southern Hainan. |
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Chen, Wen-Hsiang, Wei, et al |
bioRxiv |
Therapeutics| Thérapeutique Vaccine Research| Recherche sur les vaccins |
We constructed three variants of the recombinant receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein
(residues 331-549) in yeast as follows: (1) a “wild type” RBD (RBD219-WT), (2) a deglycosylated form (RBD219-N1) by deleting the first N-glycosylation site, and (3) a combined deglycosylated and cysteine (C538A-Tmutated variant (RBD219-N1C1). The selected
deletion or mutations did not cause any significant structural changes or alteration of function. However, RBD219-N1C1 had a higher fermentation yield, was easier to purify, and had a lower tendency to form oligomers when compared to the other two proteins. |
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Chew, NW, Sia, et al |
Circ J |
Healthcare Response | Réponse des soins de santé |
This study examined both D2B and clinical outcomes of patients with STEMI undergoing primary percutaneous coronary
intervention (PPCI). The COVID-19 pandemic and the outbreak response have had an adverse effect on PPCI service efficiency. The study reinforces the need to focus efforts on shortening D2B time, while maintaining infection control measures. |
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PMC7314116; Hospitalized Patients With COVID-19 and Human Immunodeficiency Virus: A Case
Series |
Childs, K, Post, et al |
Clin Infect Dis |
Clinical data| Données cliniques |
We report the clinical characteristics of 18 patients with human immunodeficiency virus PWH who were hospitalized with
confirmed COVID-19. |
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Chowdhury, T, Baindara, et al |
Int J Antimicrob Agents |
Therapeutics| Thérapeutique |
Seven different lipopeptides were assessed for their ability to significantly interrupt spike the (S)-glycoprotein
of SARS- CoV-2 binding with angiotensin-converting enzyme-2 (ACE2). Results confirm a strong binding affinity of LPD-12 with ACE2 which can also prevent the binding of S-protein, reciprocally. |
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Mid-Epidemic Forecasts of COVID-19 Cases and Deaths: A Bivariate Model applied to the UK |
Congdon, Peter |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The evolution of the COVID-19 epidemic has been accompanied by accumulating evidence on the underlying epidemiological
parameters. Hence there is potential for models providing mid-term forecasts of the epidemic trajectory using such information. |
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Nafamostat Mesylate in lipid carrier for nasal SARS-CoV2
titer reduction in a hamster model |
Cornelissen, Lisette, Hoefsmit, et al |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
Nafamostat (NM) has been shown in vitro to interfere with cellular virus entry by inhibition of the host transmembrane
protease serine 2 (TMPRSS2), an enzyme required for SARS-CoV-2 spike protein cleavage, a prerequisite for cell entry. We hypothesized that nasal application of NM in a liposomal layer (as additional mechanical barrier) could lower the nasal viral load and
subsequently reduce the severity of COVID-19. A single NM application reduced nasal viral load, but did not favorably improve the outcome of COVID-19, likely due to the short half-time of NM. |
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Audiological profile of patients with sars-co-v-2 pcr-positive cases |
Daikhes, NA, Karneeva, et al |
Vestnik otorinolaringologii |
Clinical data| Données cliniques |
There were 78 patients who were confirmed positive for COVID-19 PCR-positive cases and 30 normal non-infected subjects
in our study. All patients underwent audiological evaluation included tympanometry, acoustic threshold and transient evoked otoacoustic emission (TEOAE). Although hearing sensitivity was normal among some participants, it was statistically proved that TEOAEs
could pick up subtle deterioration in the outer hair cells functions and impact on the cochlear. |
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Dalise, S, Tramonti, et al |
Eur J Phys Rehabil Med |
Mental Health |
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134 patients with physical disability related to neurological disorders, who had their outpatient appointment cancelled
because of the government dispositions, were enrolled in this cross-sectional observational study to describe the overall impact of the pandemic on mental health, social condition and illness perception among patients with disabilities. People with physical
disabilities surprisingly shown milder effects of the pandemic on their psychological state and good coping skills in facing social isolation, manifesting resilience resources. |
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The effect of tocilizumab on cytokine release syndrome in COVID-19 patients |
de Cáceres, C, Martínez, et al |
Pharmacol Rep |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
A total of 75 patients with a clinical history of Accurate Respiratory Distress Syndrome (ARDS) were analysed, among
whom, 19 had mild ARDS (25.3%), 37 moderate ARDS (49.4%) and 19 severe ARDS (25.3%) in this study to assess the efficacy and safety of tocilizumab (TCZ) and to investigate the factors related to the progress and mortality of patients. Treatment with TCZ was
associated with a reduction of lymphocytopenia, C-reactive protein (CRP) levels, severe ARDS cases and fever. Although a better evolution of PaO2/FiO2 was observed in patients who received two or more doses of TCZ (38/75), there was an increase in their mortality
(47.4%) and ICU admission (86.8%). |
|
Telemonitoring type 1 diabetes patients during the COVID-19 pandemic in Brazil:
was it useful? |
de Mattos Matheus, AS, Cabizuca, et al |
Arch Endocrinol Metab |
Healthcare Response | Réponse des soins de santé |
To evaluate the performance of telemonitoring in detecting clinical and psychological needs and adherence to the protective
measures imposed by the COVID-19 pandemic in addition to providing remote assistance for patients with type 1 diabetes (T1D) in a public university center in Brazil. Telemonitoring T1D patients during the pandemic helped reduce the need for in-person consultations,
detect clinical and psychological needs, and offer support to patients in addition to monitoring suspected COVID-19 cases and the adherence to protective measures. |
|
Del Castillo Gordillo, C, Yañez Vidal, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
We describe a 54-year-old man who was admitted to a critical cardiovascular care unit for severe COVID-19 pneumonia.
He developed catastrophic respiratory failure and required deep sedation, neuromuscular blockade and prone positioning. |
|
|
Dhibar, DDP, Arora, et al |
Int J Antimicrob Agents |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study, which to our knowledge is the only clinical trial which dedicated to evaluate the efficacy of Hydroxychloroquine
(HCQ) as post exposure prophylaxis (PEP) to prevent COVID-19 in asymptomatic, high risk, household contacts of the laboratory confirmed COVID-19 cases. The study found that there was significant risk reduction for the incidence of COVID-19 in participants
who received PEP with HCQ plus standard therapy, as compared to standard therapy alone. |
|
|
Hypocalcemia is a distinctive biochemical feature of hospitalized COVID-19 patients |
di Filippo, L, Formenti, et al |
Endocrine |
Clinical data| Données cliniques |
The aim of our study was to compare, for the first time in the literature, ionized calcium levels between two groups
of patients hospitalized in the same period of the year with severe acute respiratory infections COVID-19 and non-COVID-19 related. Our study suggests that hypocalcemia may be a distinctive biochemical feature of COVID-19 potentially impacting on disease
clinical severity and representing a novel possible treatment target worth to be tested in this clinical setting. |
|
Duggal, S, Ahuja, et al |
Journal of Anaesthesiology Clinical Pharmacology |
Healthcare Response | Réponse des soins de santé |
Our study found satisfactory knowledge and appreciable concern among the practicing physicians regarding airway safety
measures in the wake of COVID-19 pandemic. However, more physicians were aware about the measures required to be adopted 'during' airway intervention. The survey highlights the need for a more focused training of the caregivers about safety measures 'before'
and 'after' airway intervention. |
|
|
Edwards, K, Allison, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
A case study of a previously well 59-year-old man required a prolonged intensive care unit stay due to severe COVID-19
symptoms. This case demonstrates a rare disease (secondary sclerosing cholangitis) that has developed specifically in the context of SARS-CoV-2 infection. A review of current literature and the underlying pathophysiology for this rare disease are discussed,
particularly in relation to COVID-19. |
|
|
PMC7604086; Deep learning-based forecasting model for COVID-19 outbreak in Saudi
Arabia |
Elsheikh, AH, Saba, et al |
Process Saf Environ Prot |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this study, long short-term memory (LSTM) network as a robust deep learning model is proposed to forecast the number
of total confirmed cases, total recovered cases, and total deaths in Brazil, India, Saudi Arabia, South Africa, Spain, and USA. The forecasting accuracy of the model was assessed using seven statistical assessment criteria, namely, root mean square error (RMSE),
coefficient of determination (R2), mean absolute error (MAE), efficiency coefficient (EC), overall index (OI), coefficient of variation (COV), and coefficient of residual mass (CRM). A reasonable forecasting accuracy was obtained. |
|
English, W, Habib Bedwani, et al |
Langenbecks Arch Surg |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We performed a multicentre, prospective, observational study from the start of the new guidelines to evaluate primarily
the impact of the COVID-19 pandemic on the use of non-operative management in appendicitis with secondary outcomes including imaging, negative appendicectomy rate (NAR), length of stay (LOS) and 30-day complications. Despite the changes in practice, short-term
complications did not increase and LOS decreased. Questions remain on the longer-term complication rates in non-operatively managed patients. |
|
|
Falach, Reut, Bar-On, et al |
bioRxiv |
Animal model | Modèle animal |
Here we report SARS-CoV-2 infection after application of low-doses of the acute-lung-injury stimulants bleomycin or
ricin in SARS-CoV-2-refractive CD-1 mice which caused a severe disease , manifested by sustained body weight loss and mortality rates of >50%. In summary, we present a novel mice-based animal model for the study of comorbidity-dependent severe COVID-19. |
|
|
Falasca, L, Nardacci, et al |
J Infect Dis |
Clinical data| Données cliniques |
To further define the pathology caused by SARS-CoV-2 across all body organs, we performed autopsies on 22 patients
with COVID-19 (18 with comorbidities and 4 without comorbidities) who died at the National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS Hospital, Rome, Italy. SARS-CoV-2 infection causes multisystem disease and significant pathology in most
organs in patients with and without comorbidities. |
|
|
Cutaneous manifestations in patients with COVID-19: clinical and histological
findings |
Fattori, A, Cribier, et al |
Hum Pathol |
Clinical data| Données cliniques |
This study aimed to describe histological features of cutaneous eruptions occurring concomitantly to SARS-CoV-2 infection
and the presence of the virus in skin lesions. Skin biopsies from six patients presenting morbilliform eruption concomitant to SARS-CoV-2 were negative for SARS-CoV2 genome and protein and therefore not to directly caused by the virus. |
|
Figueiredo, LB, Araújo, et al |
J Craniofac Surg |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to compare number and characteristics of patients admitted to a Level 1 Trauma Hospital
in for Oral and Maxillofacial Surgery in Brazil during mandatory lockdown. There was a 52.27% decrease in total number of patients and 76.34% decrease in total consultations for oral and maxillofacial surgery during the lockdown. |
|
|
Fink, DL, Khan, et al |
QJM |
Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins
de santé |
This study aimed to generate a COVID-19 diagnosis risk score for use at the time of hospital admission using the TRIPOD
checklist. 581 individuals were admitted with suspected COVID-19. The final multivariable model had AUC 0.85 and used 6 clinical variables that are routinely available in most settings. |
|
|
SARS-CoV-2 may not cause unilateral hypoglossal nerve palsy after a fortnight
of intubation |
Finsterer, J, Scorza, et al |
Am J Phys Med Rehabil |
Clinical data| Données cliniques |
Abstract and full text not available. |
|
Fowler, Z, Moeller, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins
de santé |
This study aims to model the impact of COVID-19 in Mexico City in three mitigation scenarios: (i) no social distancing,
(ii) social distancing at 50% effectiveness (iii) social distancing at 60% effectiveness. Models showed social distancing delayed time to peak case volume, total number of peak cases and hospital occupancy rates. |
|
|
PMC7586930; Robust and Specific Secretory IgA Against SARS-CoV-2 Detected in Human
Milk |
Fox, A, Marino, et al |
iScience |
Immunology | Immunologie |
Breast milk samples from eight COVID-19-recovered and seven COVID-19-suspected donors were tested for antibody (Ab)
binding to SARS-CoV2 proteins. All samples showed IgA reactivity to Spike protein, 80% had IgA binding to the Receptor-Binding Domain (RBD) and 67% of samples exhibited IgG and/or IgM binding to RBD. |
|
Freeman-Sanderson, A, Ward, et al |
Arch Phys Med Rehabil |
Healthcare Response | Réponse des soins de santé |
The article presents a set of global consensus statements to facilitate planning and delivery of speech language pathology
(SLP) rehabilitative care for patients admitted to the ICU with COVID-19, Statements were agreed upon by an international group of SLP experts from 6 continents representing 12 countries. |
|
|
Gale, Chris, Quigley, et al |
The Lancet Child & Adolescent Health |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
This paper describe the characteristics of SARS-CoV-2 infection in 66 neonates (first 28 days of life) receiving inpatient
hospital care in the UK. Of the 66 cases identified (incidence 5·6 [95% CI 4·3–7·1] per 10 000 livebirths), 28 (42%) had severe infection, 16 (24%) of whom were born preterm. Neonatal infection is uncommon in babies admitted to hospital. Infection with neonatal
admission following birth to a mother with perinatal SARS-CoV-2 infection was unlikely, and possible vertical transmission rare |
|
|
Galiatsatos, Panagis, Page, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Study aimed to see if COVID-19 ICU admissions reflect regional sociodemographic populations as well as ICU admission
trends prior to the pandemic. Compared to pre-COVID-19 ICU admissions, there was an increase in African American versus White admissions and an increase in Hispanic/Latinx versus non-Hispanic/Latinx admissions. |
|
|
Gangakhedkar, G, Solanki, et al |
Journal of Anaesthesiology Clinical Pharmacology |
Healthcare Response | Réponse des soins de santé |
This study aims at assessment of the impact of COVID-19 on the practices followed, the preparedness, and mindset of
anesthesiologists in India. Of the 707 anesthesiologists who participated, 68.3% had already worked in a COVID-19 specialty unit. Only 41.7% of the anesthesiologists felt confident that they had sufficient knowledge to deal with COVID-19 infected patients.
Fear of catching the infection and infecting loved ones were important causes of anxiety, which was seen in 95% of the participants. Majority of the participants, (64.5%) did not think that elective surgical procedures could be restarted at this point. |
|
|
Granuloma annulare triggered by SARS-CoV-2 infection. The first reported case |
García-Gil, MF, Monte Serrano, et al |
J Dermatol |
Clinical data| Données cliniques |
This editorial presents the case of a 53‐year‐old female worker in a care home with COVID‐19 cases, presenting with
an annular lesion on the second finger of her left hand (non‐dominant hand) and a papule on the knuckle of the same finger. Coinciding with the appearance of the lesions, the patient presented with anosmia, dysgeusia and cephalalgia. At that time, nasopharyngeal
reverse transcription‐polymerase chain reaction (RT‐PCR) for SARS‐CoV‐2 was carried out, which was positive. The simultaneous appearance of the GA and the typical symptoms of COVID‐19, together with nasopharyngeal RT‐PCR for SARS‐CoV‐2 and the subsequent positive
results for specific IgG antibodies 1 month after the cutaneous symptoms, allowed the diagnosis of localized GA triggered by SARS‐CoV‐2. |
|
Fear of COVID-19 Scale for Hospital Staff in Regional Hospitals in Mexico: a Brief
Report |
García-Reyna, B, Castillo-García, et al |
International Journal of Mental Health and Addiction |
Healthcare Response | Réponse des soins de santé |
This study used the Fear of COVID-19 Scale (FCV-19S) to assess the response to fear within health staff in Mexico.
Found a global FCV-19S mean score of 19.3 ± 6.9, with a significant difference in scores between women and men. The survey showed a significantly higher level of fear in nursing and administrative personnel, which may be explained by the nursing staff being
in close contact with infected patients and the administrative staff lacking understanding of the possible implications of the infection, compared with nonclinical hospital personnel. |
|
Garnett, C, Foldes, et al |
Leuk Lymphoma |
Clinical data| Données cliniques |
This editorial describes a case series of 32 adult patients with a known diagnosis of a malignant or pre-malignant
heamatological condition who presented to the hospital with symptomatic COVID-19 infection. |
|
|
Socio-economic disparities in social distancing during
the COVID-19 pandemic in the United States |
Garnier, Romain, Benetka, et al |
medRxiv |
Public Health response| Interventions de santé publique |
This study assessed how mobility patterns have varied across the United States during the COVID-19 pandemic, and identify
associations with socio-economic factors of populations. Find that the speed, depth, and duration of social distancing in the United States is heterogeneous. Particularly showed that social distancing is slower and less intense in counties with higher proportions
of people below the poverty level and essential workers; and in contrast, that social distancing is intense in counties with higher population densities and larger Black populations. Socio-economic inequalities appear to be associated with the levels of adoption
of social distancing, potentially resulting in wide-ranging differences in the impact of COVID-19 in communities across the United States. |
|
Gleissman, H, Forsgren, et al |
Acta Anaesthesiol Scand |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This case series from a single, tertiary university hospital included all mechanically ventilated patients with COVID-19
and proning to determine whether proning increases oxygenation and to evaluate responders. 44 patients, 32 males/12 females, were treated with proning for a total of 138 sessions, with median (range) 2 (1-8) sessions. Median (IQR) time for the five sessions
was 14 (12-17) hours. In the first session, median (IQR) PaO(2) :FiO(2) increased from 104 (86-122) to 161 (127-207) mm Hg (p<0.001). 36 out of 44 patients (82%) improved in PaO(2) :FiO(2) , with a significant increase in PaO(2) :FiO(2) in the first three
sessions. Median (IQR) FiO(2) decreased from 0.7 (0.6-0.8) to 0.5 (0.35-0.6) (<0.001). A significant decrease occurred in the first three sessions. PaO(2) , tidal volumes, PEEP, mean arterial pressure and norepinephrine infusion did not differ. Primarily,
patients with PaO(2) :FiO(2) approximately <120 mm Hg before treatment responded to proning. Age, sex, BMI, or SAPS 3 did not predict success in increasing PaO(2) :FiO(2) . |
|
|
González Villarreal, LC, Castellanos Galván, et al |
J Am Coll Surg |
Healthcare Response | Réponse des soins de santé |
This editorial reports on a tool -Medically Necessary Time Sensitive (pMeNTS) prioritization process score applied
for surgical cases in the pediatric surgery department between May and June 2020, with the purpose of identifying an institutional cut-off value for objectively selecting candidates suited for elective surgery. Identified a lower mean score for both scheduled
and deferred patient groups compared with the cut-off values suggested in the original study. Therefore, concluded that this tool does not encompass substantial utility in our setting, possibly due to the fact that reasons other than procedure, disease, and
patient-related factors influenced deferral of surgery for most patients. |
|
|
Grumi, S, Provenzi, et al |
Disabil Rehabil |
Mental Health |
|
This study investigated the impact of the COVID-19-related rehabilitation services lockdown on the mental health of
caregivers of children with neurodevelopmental disabilities. Worries about COVID-19 contagion and concerns for the child left without rehabilitation programs were the greatest sources of mental health burden for caregivers. Nonetheless, only the concerns for
the child were significantly associated with caregivers' reports of stress, depressive and anxious symptoms. |
|
|
Gupta, R, Mohan, et al |
Journal of Anaesthesiology Clinical Pharmacology |
Healthcare Response | Réponse des soins de santé |
This study evaluated the hospital's approach and outcomes of surgical procedures performed during the initial period
of COVID-19 pandemic so as to provide a road-map for safer approach. A total of 764 surgical procedures were conducted, of which 70.7% were elective essential surgeries, with 95.4% of these patients being discharged in stable healthy condition. Approximately
23% of the elective and 26% of the emergency surgeries was categorised in the surgical difficulty category III and majority of these were performed under general anesthesia. Postoperative mortality was 1.04%, but the overall mortality rate was approximately
2.5%. Only two patients (0.3%) tested positive for COVID-19 in this series. |
|
|
Prevalence of SARS-CoV-2 among high-risk populations in Lomé (Togo) in 2020 |
Halatoko, WA, Konu, et al |
PLoS One |
Epidemiology| Épidémiologie |
This survey estimated the prevalence of SARS-CoV-2 in high-risk populations in Lomé. A total of 955 participants with
a median age of 36 (IQR 32-43) were included, and 71.6% (n = 684) were men. Approximately 22.1% (n = 212) were from the air transport sector, 20.5% (n = 196) were from the police sector, and 38.7% (n = 370) were from the health sector. Seven participants (0.7%,
95% CI: 0.3-1.6%) had a positive rRT-PCR test result at the time of recruitment, and nine (0.9%, 95%CI: 0.4-1.8%) were seropositive for IgM or IgG against SARS-CoV-2. We found an overall prevalence of 1.6% (n = 15), 95% CI: 0.9-2.6%. The prevalence of SARS-CoV-2
infection among high-risk populations in Lomé was relatively low. |
|
Hamdy Salman, O, Ail Mohamed, et al |
Egyptian Journal of Anaesthesia |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique
RCT |
This study tested the efficacy and safety of transfusion plasma of recovered patients to treat patients with severe
infection. Plasma of recovered COVID-19 resulted in improvement of laboratory and radiological findings. In recovered COVID-19 plasma group (RCP) group, there was statistically significant improvement of clinical parameters, as well as serum ferritin, D-dimer,
c-reactive protein, and the size of lung lesion compared to control group (P ≤ 0.05). COVID-19 neutralizing antibodies appeared in serum of RCV patients, but failed to show in the control group patients during 5 days study period. |
|
|
Development of a PCR-RFLP method for detection of D614G mutation in SARS-CoV-2 |
Hashemi, SA, Khoshi, et al |
Infect Genet Evol |
Coronavirology| Coronavirologie |
This study describes a rapid and inexpensive method for the detection of D614G mutation in SARS-CoV-2. Using bioinformatics
databases and software, the authors designed the PCR-RFLP method for D614G mutation detection. Evaluated 144 SARS-CoV-2 positive samples isolated in six months in Northeastern Iran. Results showed that the prevalent type is S-D in our isolates, and a small
number of isolated belongs to the S-G type. Of 144 samples, 127 (88.2%) samples have belonged to type S-D, and 13 (9%) samples typed S-G. The first S-G type was detected on 2020 June 10. |
|
Haslbauer, JD, Perrina, et al |
Pathobiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study examined the earlier lethal community spread of COVID-19 in Basel before its initial reported emergence
in Switzerland in March 2020. A statistically significant rise in pulmonary causes of death was observed in March 2020 (p = 0.03), consistent with the reported emergence of lethal COVID-19 in Switzerland. A rise in lethal bronchopneumonia was observed between
December 2019 and January 2020, which was likely seasonal. The incidence of lethal ARDS and PE was uniformly low between October 2019 and February 2020. All autopsy cases analyzed by means of SARS-CoV-2 RT-PCR yielded negative results. |
|
|
Hazarika, M, Das, et al |
Open J Psychiatry Allied Sci |
Mental Health |
|
This study evaluated the sociodemographic profile of the distress callers, their psychosocial concerns, the interventions
provided by the service provider, and whether the service users were satisfied with the intervention(s) or not during the period of lockdown (7-24 April 2020). A total of 239 callers used the tele-counselling services. The majority of callers were male (79.1%).
Most of the callers were between 19-35 years of age group (66.5%), married (52.5%), and graduates (31%). Two-thirds of the callers called to seek guidance for their own issues and one-third for their relatives or friends. Callers had anxiety (46%), depressive
disorder (8.3%), and depressive symptoms not qualifying for depressive disorder (14%), and suicidal thoughts (5.44%). The commonest intervention provided to the callers was supportive (77.8%), followed by psychoeducation (30.5%), cognitive behaviour therapy
(24.7%), relaxation (23.6%) and behaviour therapy (13.4%). Most of the callers utilised more than one type of therapy. Overall, most of the callers were satisfied and appreciated the tele-counselling services. |
|
|
Presence of hyaluronan in lung alveoli in severe Covid-19: An opening for new treatment
options? |
Hellman, U, Karlsson, et al |
J Biol Chem |
Clinical data| Données cliniques |
This study demonstrated whether the lungs of fatal Covid-19 contain hyaluronan, as it is associated with inflammation
and ARDS and may have the appearance of liquid jelly. Lung tissue obtained at autopsy from three deceased Covid-19 patients was processed for hyaluronan histochemistry and compared with staining in normal lung tissue. Stainings confirmed that hyaluronan is
obstructing alveoli with presence in exudate and plugs, as well as in thickened perialveolar interstitium. In contrast, normal lungs only showed hyaluronan in intact alveolar walls and perivascular tissue. This is the first study to confirm prominent hyaluronan
exudates in the alveolar spaces of Covid-19 lungs, supporting the notion that the macromolecule is involved in ARDS caused by SARS-CoV-2. |
|
Ho, YI, Wong, et al |
J Med Virol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study described timely adaption of both published WHO E-gene protocol and commercially available LightMix Modular
E-gene assay to the test platform (ABI 7900 Fast real-time analyzer and TaqMan Fast One-step Virus Master Mix) available in an accredited tertiary hospital laboratory with on-going evaluation to ensure provision of quality service within time constraint. The
LightMix Modular E-gene was slightly more sensitive when compared to the WHO E-gene, both analytically and diagnostically. The assay was recommended for screening of SARS-CoV-2 infection. Thermal cycling duration of the adapted LightMix E-gene and WHO E-gene
is shortened by half and one hour respectively and allows the number of runs to double when 24-hour round-the-clock service is provided. Increase in testing capacity could support surges in testing demand, which is essential to control the current SARS-CoV-2
pandemic, to prevent potential overwhelming of the healthcare system and to optimize utilization of the isolation beds. |
|
|
The Role of Health Care Human Factors in Responding to COVID-19: Findings From an
Industry Survey |
Howe, J, Parker, et al |
Ergonomics in Design |
Healthcare Response | Réponse des soins de santé |
A survey of human factors practitioners working in health care was administered to understand their challenges and
successes encountered when responding to the COVID-19 pandemic. Focus areas identified by survey respondents related to workflow, physical environments, communication, and implementation of new technologies. The results from this study can be used by human
factors practitioners to demonstrate the common challenges and opportunities for applying human factors to system redesign within their health care organizations. These findings can also be used to encourage investments in human factors by health care organizations
and the federal government. © 2020 by Human Factors and Ergonomics Society. |
|
An Empirical Evaluation of Bluetooth-based Decentralized Contact Tracing in Crowds |
Hsiao, Hsu-Chun, Huang, et al |
arXiv |
Public health interventions*| Interventions de sant&eacute; publique |
This study investigated the effectiveness of Bluetooth-based contact tracing in crowd environments with a total of
80 participants, emulating classrooms, moving lines, and other types of real-world gatherings. The results confirm that Bluetooth RSSI is unreliable for detecting proximity, and that this inaccuracy worsens in environments that are especially crowded. |
|
Genetic variants are identified to increase risk
of COVID-19 related mortality from UK Biobank data |
Hu, Jianchang, Li, et al |
medRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Studies have reported that males and some ethnic groups are at increased risk of death from COVID-19, which implies
that individual risk of death might be influenced by host genetic factors. This project considers the mortality as the trait of interest and perform a genome-wide association study (GWAS) of data for 1,778 infected cases (445 deaths, 25.03%) distributed by
the UK Biobank. Found 8 super-variants that are consistently identified across multiple replications as susceptibility loci for COVID-19 mortality. The identified risk factors on Chromosomes 2, 6, 7, 8, 10, 16, and 17 contain genetic variants and genes related
to cilia dysfunctions (DNAH7 and CLUAP1), cardiovascular diseases (DES and SPEG), thromboembolic disease (STXBP5), mitochondrial dysfunctions (TOMM7), and innate immune system (WSB1). It is noteworthy that DNAH7 has been reported recently as the most downregulated
gene after infecting human bronchial epithelial cells with SARS-CoV2. |
|
PMC7606077; Population-weighted exposure to air pollution and COVID-19 incidence
in Germany |
Huang, G, Brown, et al |
Spat Stat |
Epidemiology| Épidémiologie |
This study investigated whether long-term exposure to air pollution increases the risk of COVID-19 infection in Germany.
The results show that nitrogen dioxide (NO 2 ) is significantly associated with COVID-19 incidence, with a 1 μg m -3 increase in long-term exposure to NO 2 increasing the COVID-19 incidence rate by 5.58% (95% credible interval CI]: 3.35%, 7.86%). This result
is consistent across various models. The analyses can be reproduced and updated routinely using public data sources and shared R code. |
|
Huang, Y, Lyu, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective study, the clinical characteristics, treatment and outcome data were collected and analyzed from
676 COVID-19 patients stratified into 140 non-survivors and 536 survivors. Found that the levels of Dimerized plasmin fragment D (D-dimer), C-reactive protein (CRP), lactate dehydrogenase (LDH), procalcitonin (PCT) were significantly higher in non-survivals
on admission (non-survivors vs. survivors: D-Dimer ≥ 0.5 mg/L, 83.2% vs. 44.9%, P<0.01; CRP ≥10 mg/L, 50.4% vs. 6.0%, P<0.01; LDH ≥ 250 U/L, 73.8% vs. 20.1%, P<0.01; PCT ≥ 0.5 ng/ml, 27.7% vs. 1.8%, P<0.01). Moreover, dynamic tracking showed D-dimer kept increasing
in non-survivors, while CRP, LDH and PCT remained relatively stable after admission. D-dimer has the highest C-index to predict in-hospital mortality, and patients with D-dimer levels ≥0.5 mg/L had a higher incidence of mortality (Hazard Ratio: 4.39, P<0.01). |
|
|
Hüppe, D, Niederau, et al |
Z Gastroenterol |
Healthcare Response | Réponse des soins de santé |
To analyze the influence of the pandemic on the healthcare of patients with chronic hepatitis C in Germany, we carried
out a structured questionnaire among all centres participating in the German Hepatitis C-Registry (DHC-R). Diagnosis, therapy and monitoring of patients with chronic hepatitis C were impaired during the COVID-19 pandemic. Nevertheless, the majority of the
centres did not see healthcare problems for these patients in the medium and long term. However, the fact that the diagnosis of liver decompensations with potential lethal consequences was delayed in a considerable number of patients causes major concern. |
|
|
Ibrahim, MA, Al-Najafi, et al |
Processes |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this paper, we study and investigate the spread of the coronavirus disease 2019 (COVID-19) in Iraq and Egypt by
using compartmental, logistic regression, and Gaussian models. We developed a generalized SEIR model for the spread of COVID-19, taking into account mildly and symptomatically infected individuals. The results provide discouraging forecasts for Iraq from 22
February to 8 October 2020 and for Egypt from 15 February to 8 October 2020. Our sensitivity analyses of the basic reproduction number allow us to conclude that the most effective way to prevent COVID-19 cases is by decreasing the transmission rate. The findings
of this study could therefore assist Iraqi and Egyptian officials to intervene with the appropriate safety measures to cope with the increase of COVID-19 cases. |
|
|
Italiano, J, Bush, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
This report describes the duration of viral shedding and timing of seroconversion in a young adult RT recipient with
COVID-19 who presented with severe diarrhoea and acute kidney injury requiring dialysis. She developed anti-SARS-CoV-2 IgG antibody after 5 weeks despite persistently shedding the virus in the nasopharynx until 6 weeks after symptom onset. Further studies
are needed to determine if immunosuppressed patients have prolonged viral shedding and are still contagious despite seroconversion. |
|
|
Jackson, J, Silvestri, et al |
Ophthalmic Physiol Opt |
Healthcare Response | Réponse des soins de santé |
In this paper we highlight the impact which the disruption of secondary care ophthalmic services, resulting from COVID-19,
has had on Sight Impairment (SI) and Severe Sight Impairment (SSI) certification in Northern Ireland. It is inconceivable that COVID-19 has reduced the incidence of sight-threatening eye disease. We must therefore assume that a flood of newly presenting sight
loss will present once the pandemic has passed. New presentations will include those who would normally have attended during the lockdown period, and patients who, had they accessed ophthalmic care at the appropriate time, would have been saved from severe
levels of blindness. The implications of the predicted increase in demand for medical, social and low vision related services are huge. |
|
|
Jin, S, He, et al |
J Bone Joint Surg Am |
Healthcare Response | Réponse des soins de santé |
Under the guidance of experts in our hospital, we studied and developed a series of measures suitable for enabling
the resumption of sports medicine work while protecting both patients and medical workers. we present the measures undertaken as part of the safety protocol for the resumption of activities at our sports medicine center during the postepidemic period. |
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Jyotisha, Singh, S, et al |
J Biomol Struct Dyn |
Vaccine Research| Recherche sur les vaccins |
In this study, immunoinformatics approach was employed to design a novel multi-epitope vaccine using RBD of SARS-CoV-2
spike protein. The potential B- and T-cell epitopes were selected from RBD sequence using various bioinformatics tools to design the vaccine construct. The in silico designed multi-epitope vaccine encompasses 146 amino acids with an adjuvant (human beta-defensin-2),
which was further computationally evaluated for several parameters including antigenicity, allergenicity and stability. Subsequently, three-dimensional structure of vaccine construct was modelled and then docked with various toll-like receptors. Molecular
dynamics (MD) study of docked TLR3-vaccine complex delineated it to be highly stable during simulation time and the stabilization of interaction was majorly contributed by electrostatic energy. The docked complex also showed low deformation and increased rigidity
in motion of residues during dynamics. Altogether, our study suggests that the designed vaccine candidate containing RBD region could provide the specific humoral and cell-mediated immune responses against SARS-CoV-2. |
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Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to
SARS-CoV-2 Infection |
Kaneko, N, Satta, et al |
Stroke |
Coronavirology| Coronavirologie |
We tested the hypothesis that viral S-protein binding to brain microvascular cells is dependent not only on molecular
interaction with ACE2 but also requires a flow-mediated stimulus. We further sought to identify the brain-specific effect on endothelial cell gene expression triggered by viral S-protein binding. Brain endothelial cells are susceptible to direct SARS-CoV-2
infection through flow-dependent expression of ACE2. Viral S protein binding triggers a unique gene expression profile in brain endothelia that may explain the association of SARS-CoV-2 infection with cerebrovascular events. |
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Karakus, O, Anantrasirichai, et al |
IEEE transactions on ultrasonics, ferroelectrics, and frequency control |
Clinical data| Données cliniques |
In this article, we present a novel method for line artifacts quantification in lung ultrasound (LUS) images of COVID-19
patients. We employ a simple local maxima detection technique in the Radon transform domain, associated with known clinical definitions of line artifacts. Despite being nonconvex, the proposed technique is guaranteed to convergence through our proposed Cauchy
proximal splitting (CPS) method, and accurately identifies both horizontal and vertical line artifacts in LUS images. To reduce the number of false and missed detection, our method includes a two-stage validation mechanism, which is performed in both Radon
and image domains. We evaluate the performance of the proposed method in comparison to the current state-of-The-Art B-line identification method, and show a considerable performance gain with 87% correctly detected B-lines in LUS images of nine COVID-19 patients. |
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Karami, A, Hasani, et al |
Sens Actuators B Chem |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we report a simple colorimetric strategy derived from linker-based single-component assembly of gold nanoparticle-core
spherical nucleic acids (AuNP-core SNAs) for visual detection of PCR products of SARS-CoV-2 ribonucleic acid (RNA) template. A palindromic linker is designed based on SARS-CoV-2 specific E gene to program the identical colloidal SNAs into large assemblies
along with a distinct red-to-purple color change. The linker acts as a probe of SARS-CoV-2 RNA in conventional PCR reaction. In the presence of the correct template the palindromic linker, which is complementary to a short region within the target amplicon,
is cleaved by 5'-exonuclease activity of deoxyribonucleic acid (DNA) polymerase. Cleavage of the palindromic linker during the amplification process inhibits the single-component assembly formation of SNAs. So, positive and negative viral samples produce simply
red and purple colors in the post PCR colorimetric test, respectively. Evaluation of the samples obtained from cases with laboratory-confirmed SARS-CoV-2 infection revealed that our assay can rival with real-time PCR method in sensitivity. |
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Kim, Chae Won, Oh, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
In this study, we reanalyzed scRNA-seq data of cells from bronchoalveolar lavage fluids of patients with COVID-19 with
mild and severe symptoms, focusing on antibody-producing cells. In patients with severe disease, B cells seemed to be more activated and expressed more immunoglobulin genes compared with cells from patients with mild disease, and macrophages expressed higher
levels of the TNF superfamily member B-cell activating factor but not of APRIL (a proliferation-inducing ligand). In addition, macrophages from patients with severe disease had increased pro-inflammatory features and pathways associated with Fc receptor-mediated
signaling, compared with patients with mild disease. CCR2-positive plasma cells accumulated in patients with severe disease, probably because of increased CCL2 expression on macrophages from patients with severe disease. Together, these results support that
different characteristics of B cells might affect the severity of COVID-19 infection. |
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Multisystem Inflammatory Syndrome in Children Related to COVID-19: the First Case
in Korea |
Kim, H, Shim, et al |
J Korean Med Sci |
Clinical data| Données cliniques |
We report the first Korean child who met all the criteria of MIS-C with features of incomplete KD or KD shock syndrome. |
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Kim, HJ, Han, et al |
J Med Internet Res |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The purpose of this study was to develop a machine learning model that predicts the need for intensive care for patients
with COVID-19 using easily obtainable characteristics-baseline demographics, comorbidities, and symptoms. A total of 4787 patients were included in the analysis, of which 3294 were assigned to the derivation group and 1493 to the validation group. Among the
4787 patients, 460 (9.6%) patients needed intensive care. The AUC of the XGBoost model was 0.897 (95% CI 0.877-0.917) for the derivation group and 0.885 (95% CI 0.855-0.915) for the validation group. Both the AUCs were superior to those of CURB-65, which were
0.836 (95% CI 0.825-0.847) and 0.843 (95% CI 0.829-0.857), respectively. |
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Kim, S, Lee, et al |
Immune Network |
Coronavirology| Coronavirologie |
We were interested in investigating the mutation region of S gene of SARS-CoV2 from Korean COVID-19 patients. New mutation
sites were found in the critical receptor binding domain (RBD) of S gene, which is adjacent to the aforementioned D614G mutation residue. This specific sequence data demonstrated the active progression of SARS-CoV2 by mutations in the RBD of S gene. The sequence
information of new mutations is critical to the development of recombinant SARS-CoV2 spike antigens, which may be required to improve and advance the strategy against a wide range of possible SARS-CoV2 mutations. |
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Psychological resistance of student youth to information stress in the COVID-19 pandemic |
Kislyakov, PA |
Perspektivy Nauki i Obrazovania |
Mental Health |
|
Article in Russian. The purpose of the study was to study the features of information behavior, psychological stability
and ways to cope with information stress for Russian students during the COVID-19 pandemic. The cluster analysis allowed identifying four types of students’ information behavior during the COVID-19 pandemic: phobic (20%), cognitive (45%), nihilistic (20%)
and circulating behavior (15%). To a greater extent, in order to cope with information stress during the COVID-19 pandemic, student youth use constructive coping strategies for planning (xave = 58.5±21.7), positive reassessment (xave = 51.9±19.3), self-control
(xave = 47.5±17.8), characterized by a purposeful analysis of the situation and possible behavior options, including the determination of personal development directions. Besides, a significant part of students resort to the use of destructive coping strategies
of avoidance, confrontation, distancing, caused by negative experiences, leading to the circulation of unofficial information about the pandemic. Half of the respondents need social support. |
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Kujawa, A, Green, et al |
Depress Anxiety |
Mental Health |
|
We developed the Pandemic Stress Questionnaire (PSQ) and tested its psychometric properties, characterized experiences
in emerging adults, and examined associations with internalizing symptoms. Results supported the validity/reliability of PSQ total scores and indicated that stressful events were highly prevalent in May, particularly among younger, female, and Black emerging
adults. Symptoms of depression and anxiety were high overall, but decreased at the follow-up assessment. Pandemic-related stress was moderately associated with both depression and anxiety at each assessment, but baseline stress did not predict change in symptoms
when controlling for baseline symptoms. |
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Kumar, BK, Rohit, et al |
Virus Res |
Coronavirology| Coronavirologie |
The in silico analysis of 2086 whole genome sequences from India performed in this study provides the first observation
on the extensive deletion of amino acid residues in the C-terminal region of the envelope glycoprotein in 34 Indian SARS-CoV-2 genomes. These amino acid deletions map to the homopentameric interface and PDZ binding motif (PBM) present in the C-terminal region
of E protein as well as immediately after the reverse primer binding region as per Charité protocol in 26 of these genomes, hence, their detection through RT-qPCR may not be hampered and therefore E gene-based RT-qPCR would still detect these isolates. Eight
genomes from the State of Odisha had deletion even in the primer binding site. It is possible that the deletions in the C-terminal region of E protein of these genomes are a result of adapting to a newer geographical area and host. The information on the clinical
status was available only for 9 out of 34 cases and these were asymptomatic. |
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Laporte, Manon, Stevaert, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We here reveal features of the coronavirus spike (S) protein, which optimize the virus towards different parts of the
respiratory tract. First, the SARS-CoV-2 spike (SARS-2-S) reached higher levels in pseudoparticles when produced at 33°C instead of 37°C. Even stronger preference for the upper airway temperature of 33°C was evident for the S protein of HCoV-229E, a common
cold coronavirus. In contrast, the S proteins of SARS-CoV-1 and MERS-CoV favored 37°C, in accordance with their preference for the lower airways. Next, SARS-2-S proved efficiently activated by TMPRSS13, besides the previously identified host cell protease
TMPRSS2, which may broaden the cell tropism of SARS-CoV-2. TMPRSS13 was found to be an effective spike activator for the virulent coronaviruses but not the common cold HCoV-229E virus. Activation by these proteases requires pre-cleavage of the SARS-2-S S1/S2
cleavage loop, and both its furin motif and extended loop length proved critical to achieve virus entry into airway epithelial cells. Finally, we show that the D614G mutation in SARS-2-S increases S protein stability and expression at 37°C, and promotes virus
entry via cathepsin B/L activation. These spike properties might promote virus spread, potentially explaining why the G614 variant is currently predominating worldwide. |
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PMC7640922; Caution against precaution: A case report on silent hypoxia in COVID-19 |
Lari, A, Alherz, et al |
Ann Med Surg (Lond) |
Clinical data| Données cliniques |
A 66 year old female with multiple comorbidities initially presented with a cough, fever and an oxygen saturation of
70% on room air in the absence of respiratory distress or altered mentation. She subsequently tested positive for COVID-19 and was admitted to the intensive care unit; received oxygen via high flow nasal cannula and continuous positive pressure mask. The patient
remained in the intensive care unit for 40 days under close observation and exhibited multiple episodes of silent hypoxia on weaning oxygen. |
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Human mobility trends during the early stage of the COVID-19 pandemic in the
United States |
Lee, M, Zhao, et al |
PLoS One |
Public Health response| Interventions de santé publique |
We aim to provide tangible evidence of the human mobility trends by comparing the day-by-day variations across the
U.S. from January 2020 to early April 2020. The population staying home has increased in all states before the stay-at-home mandates implemented and becomes more stable after the order with a smaller range of fluctuation. The public had been taking active
responses, voluntarily staying home more, to the in-state confirmed cases while the stay-at-home orders stabilize the variations. As the estimated teleworking rates also continue to incline throughout the study period, the teleworking trend can be another
driving factor for the growing stay-at-home population. We confirm that there exists overall mobility heterogeneity between the income or population density groups. The study suggests that public mobility trends are in line with the government message urging
to stay home. |
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Lee, RWK, Loy, et al |
BMC Pregnancy Childbirth |
Public Health response| Interventions de santé publique |
The aims of the study are to understand the attitudes and precaution practices of non-infected pregnant women towards
the COVID-19 outbreak in Singapore. Social demographical factors including age > 36 years old, Malay ethnicity, employment in front line jobs and attendance at high-risk clinics are likely to influence the attitudes and precaution practices among pregnant
women towards COVID-19 in Singapore. Knowledge gained from our cross-sectional online survey can better guide clinicians to communicate better with pregnant women. |
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Classification of Severe and Critical COVID-19 Using Deep Learning and Radiomics |
Li, C, Dong, et al |
IEEE J Biomed Health Inform |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to construct a model integrating information from radiomics and deep learning (DL) features to discriminate
critical cases from severe cases of COVID-19 using computed tomography (CT) images. METHODS: We retrospectively enrolled 217 patients from three centers in China, including 82 patients with severe disease and 135 with critical disease. Patients were randomly
divided into a training cohort (n=174) and a test cohort (n=43). We extracted 102 3-dimensional radiomic features from automatically segmented lung volume and selected the significant features. RESULTS: The merged model could distinguish critical patients
with AUCs of 0.909 (95% confidence interval CI]: 0.8590.952) and 0.861 (95% CI: 0.7530.968) in the training and test cohorts, respectively. Stratified analysis indicated that our model was not affected by sex, age, or chronic disease. Moreover, the results
of the merged model showed a strong correlation with patient outcomes. |
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Cardiac damage in patients with the severe type of coronavirus disease 2019 (COVID-19) |
Li, J, Zhang, et al |
BMC Cardiovasc Disord |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we aimed to explore the cardiac damage in patients with COVID-19. METHODS: We collected data of 100
patients diagnosed as severe type of COVID-19 from February 8 to April 10, 2020, including demographics, illness history, physical examination, laboratory test, and treatment. RESULTS: Cardiac damage occurred in 25 patients. In the subgroups, hsTnI was
significantly higher in elder patients and men. The prevalence of increased NTproBNP was significantly higher in men than in women, but was similar between the elder and young patients. |
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Li, R, Li, et al |
Brief Bioinform |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We used a series of network pharmacology-based and computational analyses to understand and characterize the binding
capacity, biological functions, pharmacological targets and therapeutic mechanisms of niacin in CRC/COVID-19. MEASUREMENTS AND MAIN RESULTS: We revealed the clinical characteristics of CRC patients and COVID-19 patients, including predisposing genes, survival
rate and prognosis. The analysis indicated that niacin could help in treating CRC/COVID-19 through cytoprotection, enhancement of immunologic functions, inhibition of inflammatory reactions and regulation of cellular microenvironment. |
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Lyu, H, Yao, et al |
Risk Management and Healthcare Policy |
Healthcare Response | Réponse des soins de santé |
Material and Methods: Convenience sampling was applied to collect questionnaire samples from 216 nurses (from 12 cities
in 6 provinces). General information questionnaires, organizational identity scale (OIQ), psychological resilience scale (CD-RISC), and Utrecht Work Engagement Scale (UWES) were used as tools for data collection. Results: Both organizational identification
and psychological resilience had a positive impact on work engagement. Our results revealed that organizational identity could directly affect nursing. It can also indirectly affect nurses’ work engagement through the intermediary role of psychological resilience.
In face of the COVID-19 epidemic, hospitals and nursing managers could improve the level of nurses’ job involvement by improving organizational identity, which in turn may have a positive effect on psychological resilience. |
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Mady, A, Aletreby, et al |
Ann Med Surg (Lond) |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
A case-series of 61 patients admitted to our intensive care unit (ICU) between August 12 and September 12, 2020 with
confirmed COVID-19 pneumonia and rapidly evolving ARF requiring oxygen support therapy and/or mechanical ventilation was retrospectively analyzed. We examined whether intravenous administration of tocilizumab, a monoclonal interleukin-6 receptor antibody,
was associated with improved outcome. Outcome measures such as mortality on day-14, ICU length of stay, and rate of nosocomial acquired bacterial infections were also analyzed. Results: No serious adverse effects due to tocilizumab therapy were recorded. However,
twelve patients (19.6%) developed nosocomial acquired infections. ICU length of stay was 13 days, and mortality on day-14 was 24.6%. Tocilizumab did not affect the mortality of critically ill COVID-19 patients. |
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Makaris, E, Kourek, et al |
Hellenic J Cardiol |
Healthcare Response | Réponse des soins de santé |
The aim of the study was to assess whether there was reduction in AMI hospital admissions in the region of Messinia
in Greece during the Covid-19 lockdown period. Admissions of patients with AMI reduced within the lockdown period of 2020 indicating significant decrease compared to the respective period of both 2018 and 2019. In-hospital and out of hospital mortality of
patients with AMI among pre-lockdown, lockdown and post-lockdown period of 2020, as well as between 2019 and 2020 remained unchanged. |
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Marchini, S, Zaurino, et al |
J Community Psychol |
Mental Health |
|
This study evaluated the risks and protective factors in mental health in 825 emerging adults aged from 18 to 25 years
old in Belgium and in Italy. We conducted an online survey on the secured platform Research Electronic Data Capture. The primary outcomes were the resilience scale for adults (RSA) and the University of California Los Angeles Loneliness Scale. The secondary
outcomes included mental health status in terms of professional help seeking, use of psychotropic drugs, admission to a psychiatric department before and during lockdown measures. Responders were divided into three groups following the mental healthcare needs
(MHCN) before and after the lockdown measures. The group who experienced an increase in MHCN represented almost 5% of the assessed youth. Statistically significant differences were found in means of RSA total score and RSA perception of self. |
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Matschinske, J, Salgado-Albarrán, et al |
Assay Drug Dev Technol |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this article, we showcase how to individuate drug targets and potentially repurposable drugs in silico using CoVex
a recently presented systems medicine platform for COVID-19 drug repurposing. Our analysis reveals GLA, PLAT, and GGCX as potential drug targets, and urokinase, argatroban, dabigatran etexilate, betrixaban, ximelagatran and anisindione as potentially repurposable
drugs. |
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Mayorga, Lia, Samartino, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique Healthcare Response | Réponse des soins de santé |
Methods: We present a compartmental model for the disease where symptomatic and asymptomatic individuals move separately.
Overall, the simulations we carried out were notably more effective when mitigation measures were not relaxed in between the suppressive actions. Since asymptomatics or very mildly affected patients are the vast majority, we studied the impact of detecting
and isolating them. The removal of asymptomatics from the infectious pool remarkably lowered the effective reproduction number, healthcare burden and overall fatality. Furthermore, different suppression triggers regarding ICU occupancy were attempted. The
best scenario was found to be the combination of ICU occupancy triggers (on: 50%, off: 30%) with the detection and isolation of asymptomatic individuals. |
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McBride, O, Murphy, et al |
Int J Methods Psychiatr Res |
Mental Health |
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METHODS: A longitudinal, internet panel survey was designed to assess: (1) COVID-19 related knowledge, attitudes, and
behaviors; (2) the occurrence of common mental health disorders as well as the role of (3) psychological factors and (4) social and political attitudes, in influencing the public's response to the pandemic. RESULTS: Two thousand and twenty five adults were
recruited at baseline, and 1406 were followed-up one-month later (69.4% retention rate). The baseline sample was representative of the UK population in relation to economic activity, ethnicity, and household composition. Attrition was predicted by key socio-demographic
characteristics, and an inverse probability weighting procedure was employed to ensure the follow-up sample was representative of the baseline sample. |
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Long term outcomes of critically ill COVID-19 pneumonia patients: early learning |
McCue, C, Cowan, et al |
Intensive Care Med |
Long-Term Sequelae |
|
Patients are routinely invited to our multi-disciplinary ICU follow-up clinic between 12–16 weeks post discharge. From
March 14th, 2020 until April 28th, 2020, 51 patients required invasive mechanical ventilation for COVID-19 pneumonia in our ICU. Complete records of 43 patients were available for review. The median HUS was 0.752 . New disability including breathlessness were
reported as impacting on employability; a small number of patients described they were unable to return to work due to COVID-19 employment restrictions. Fourteen (67%) patients complained of new pain; 29% of pain was classified as severe or extreme. This cohort
had a significant burden of acute illness requiring prolonged mechanical ventilation and high rates of neuromuscular blockade. |
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Medas, F, Cappellacci, et al |
Ann Med Surg (Lond) |
Epidemiology| Épidémiologie Immunology | Immunologie |
The aim of this study was to assess the seroprevalence of SARS-Cov-2 in the setting of a non-dedicated COVID-19 hospital
in a low CoV-2 incidence area. Among 86 patients included in the study, we found 2 (2.3%) patients positive for both SARS-CoV-2 specific IgM and IgG, 2 (2.3%) for only SARS-CoV-2 specific IgM, and 1 for only SARS-CoV-2 specific IgG. Thus, seroprevalence for
SARS-CoV-2 was 5.8%; nasopharyngeal swab was negative in all the cases. |
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Medetalibeyoglu, A, Emet, et al |
Cardiovasc J Afr |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The purpose of this article was to report the low rates of intensive care unit admission and mortality in intermediate-
and high-risk COVID-19 patients, and to share our clinical approach with other colleagues. METHODS: Patients admitted to the emergency department in the Department of Internal Medicine, Faculty of Medicine, Istanbul University, with laboratory or clinically
and radiologically confirmed COVID-19 were included in this retrospective cross-sectional study, which was conducted from 11 March to 10 April 2020. RESULTS: Mortality and intensive care unit admission rates were statistically significantly higher in patients
with cardiac injury than in those without. There was a positive correlation between levels of high-sensitivity TNT and fibrinogen, D-dimer, ferritin, procalcitonin and C-reactive protein. |
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Melazzini, F, Colaneri, et al |
Intern Emerg Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
we conducted a retrospective, observational study on 259 consecutive COVID-19 patients admitted to an academic tertiary
referral hospital in Northern Italy between March 19th and April 6th, 2020. Records of COVID-19 patients with a definite VTE event were reviewed for demographic information, co-morbidities, risk factors for VTE, laboratory tests, and anticoagulation treatment.
Twenty-five cases among 259 COVID-19 patients developed VTE (9.6%), all of them having a Padua score > 4, although being under standard anticoagulation prophylaxis since hospital admission. In the VTE subcohort, we found a significant positive correlation
between platelet count (PLT) and either C reactive protein (CRP) or lactate dehydrogenase (LDH), while a significant inverse correlation was observed between PLT and mean platelet volume. |
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Meo, SA, Abukhalaf, et al |
Eur J Med Res |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
This study aimed to assess the impact of 15 days before, 15 days during, and 15 days after the lockdown on the trends
in the prevalence and mortality in 27 countries during COVID-19 pandemic. METHODS: Twenty-seven countries were randomly selected from the different continents. The information on the trends in the prevalence and mortality due to COVID-19 pandemic in 27 countries
was obtained from World Health Organization and lockdown data were obtained from concerned countries and their ministries. RESULTS: The findings showed that 15 days after the lockdown there was a trend toward a decline, but no significant decline in the mean
prevalence and mean mortality rate due to the COVID-19 pandemic compared to 15 days before, and 15 days during the lockdown in 27 countries. The mean growth factor for number of cases was 1.18 and for mortality rate was 1.16. |
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Mercer, ST, Agarwal, et al |
Perioper Care Oper Room Manag |
Healthcare Response | Réponse des soins de santé |
METHODS: All trauma and orthopaedic emergency surgery were analysed for May 2019 and May 2020. RESULTS: A total of
222 patients underwent emergency orthopaedic surgery in May 2019 and 161 in May 2020. A statistically significant increase in all timings was demonstrated in 2020 apart from anaesthetic time which demonstrated a significant decrease. |
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Assessment of mortality in correlation with comorbidities in COVID-19 patients
of Telangana state |
Mesipogu, Rajarao, Adeula, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of the study is to describe the clinical and epidemiological characteristics of 201 deceased from Telangana.
We retrospectively collected all consecutive death cases with laboratory‐confirmed COVID‐19 infection admitted from March to mid-June at Gandhi Hospital the nodal centre designated for COVID-19 in Telangana. Results A total of 15394 patients with confirmed
COVID‐19 test were admitted at Isolation wards between March 2020 and June 2020 and 253 death cases were reported till the submission of this paper. The mean age of death is 57.0 ys in our study, 40.7% (88) deaths were above 60 years and 71.4% (147) were male.
Several comorbid conditions existed with COVID-19 death cases among which hypertension being the most common comorbidity (60.1%). Lymphopenia was observed in 46% cases while lymphopenia with comorbidity was recorded in 63% cases. |
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Determining extent of COVID-19 pneumonia on CT based on biological variables |
Mickael, T, Ahmed, et al |
Respir Med |
Clinical data| Données cliniques |
The objective was to determine for the biological variables correlating with disease severity the cut-off values showing
the best performance to predict the parenchymal extent of the pneumonia. Lactic Acid Dehydrogenase (LDH) showed the strongest correlation with the extent of Covid-19 pneumonia on CT. |
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Effects of the COVID-19 Pandemic on Domestic Violence in Los Angeles |
Miller, AmaliaR, Segal, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
Authors use high-frequency, real-time data from Los Angeles on 911 calls, crime incidents, arrests, and calls to a
Domestic Violence (DV) hotline to study the effects of COVID-19 shutdowns on DV. Results highlight the heterogeneous effects of the pandemic across DV measures and caution against relying on a single data type or source. |
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Modig, K, Ahlbom, et al |
Eur J Public Health |
Epidemiology| Épidémiologie |
Authors estimate age- and sex-specific mortality rates due to COVID-19 in Sweden. The excess mortality has been high
in older ages during the pandemic, but it remains to be answered if this is because of age itself being a prognostic factor or a proxy for comorbidity. |
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COVID-19 unfolding filariasis: The first case of SARS-CoV-2 and Wuchereria bancrofti
coinfection |
Mohamed, MFH, Mohamed, et al |
PLoS Negl Trop Dis |
Clinical data| Données cliniques |
Authors report the first case of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, unveiling
the diagnosis of asymptomatic filariasis. It is prudent to keep a broad differential diagnosis when faced with SARS-CoV-2-infected patients. |
|
Mompeán, Miguel, Treviño, et al |
bioRxiv |
Coronavirology| Coronavirologie |
To enable inhibitor screening and to uncover conformational preferences and dynamics, authors have expressed and purified
the 13C,15N-labeled C-terminal region of Nsp2. The chemical shift data confirm that this region is chiefly disordered, but contains two five-residue segments that adopt a small population of β-strand structure. |
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Monreal, E, de la Maza, et al |
J Med Virol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Authors discuss the role of immunosuppression among Coronavirus disease 2019 (COVID-19) patients, Non-severe immunosuppression
was associated with a lower risk of moderate-severe acute respiratory distress syndrome (ARDS), especially among autoimmune diseases (AD). |
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Pregnant Women’s Well-being and Worry During the COVID-19 Pandemic: A
Comparative Study |
Mortazavi, Forough, Mehrabadi, et al |
Research Square prepub |
Mental Health |
|
Authors investigated worry and well-being and associated factors among pregnant women during the COVID-19 epidemic.
The percentage of women experiencing a low well-being state was relatively high. |
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Murray, K, Quinn, et al |
Rheumatology (Oxford) |
Epidemiology| Épidémiologie |
The aim of this study was to establish, amongst Irish rheumatic musculoskeletal disease (RMD) patients, rates of COVID-19
symptoms and positive tests, DMARD adherence and attitudes to virtual clinics. The rate of COVID-19 positivity in RMD patients was similar to the general population. |
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SARS-CoV-2 epitope mapping on microarrays highlights
strong immune-response to N protein region |
Musicò, Angelo, Frigerio, et al |
bioRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Authors report a workflow for SARS-CoV-2 epitope discovery on peptide microarrays. A summary study testing 50 serum
samples highlighted an epitope of the N protein (region 155-171) providing 92% sensitivity and 100% specificity of IgG detection in Covid-19 samples thus being a promising candidate for rapid implementation in serological tests. |
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Curse of Small Sample Size in Forecasting of the Active Cases in COVID-19 Outbreak |
Nakıp, Mert, Çopur, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper gives an explanation for the failure of machine learning models in this particular forecasting problem.
Results show that the accurate forecasting of the active cases with high generalization ability is possible up to 3 days only because of the small sample size of COVID-19 data. |
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Nawattanapaiboon, K, Pasomsub, et al |
Analyst |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Authors aimed to develop a visual diagnostic platform for SARS-CoV-2 based on colorimetric RT-LAMP with levels of sensitivity
and specificity comparable to that of commercial qRT-PCR assays. Results indicate that the developed colorimetric RT-LAMP provides a simple, sensitive and reliable approach for the detection of SARS-CoV-2 in clinical samples, implying its beneficial use as
a diagnostic platform for COVID-19 screening. |
|
|
Nazerian, P, Lumini, et al |
Intern Emerg Med |
Transmission Healthcare Response | Réponse des soins de santé |
In this letter to the editor authors describe a study conducted to evaluate the burden of ED-acquired COVID-19 (EDAC)
in patients discharged from a reorganized Italian ED during COVID-19 outbreak. The use of protective equipment for both patients and healthcare workers and rapid admission of highly suspected COVID-19 patients needing hospitalization resulted in no EDAC among
patients discharged from ED after reorganization. |
|
|
Nguyen, Hoang Long, Pan, et al |
arXiv |
Public Health response| Interventions de santé publique |
Authors aim to investigate the relation between Google search trends and the spreading of the novel coronavirus (COVID-19)
over countries worldwide, to predict the number of cases. Results show that Google search trends are highly associated with the number of reported confirmed cases, where the Deep Learning approach outperforms other forecasting techniques. |
|
|
Impact of COVID-19 Lockdown Measures on Spanish People with Chronic Pain: An Online Study
Survey |
Nieto, R, Pardo, et al |
J Clin Med |
Public Health response| Interventions de santé publique |
In this cross-sectional study, an online survey of relevant chronic pain domains, coping strategies, triggers and potential
related variables was answered by 502 Spanish individuals with chronic pain. Results highlight the negative effects of lockdown on patients with chronic pain as well as the need to make available cost-effective and remotely accessible healthcare resources
for counteracting them. |
|
Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry |
Núñez-Gil, IJ, Fernández-Pérez, et al |
Intern Emerg Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The primary end-point of this work was all-cause mortality aiming to produce a mortality risk score calculator. COVID-19
produces important mortality, mostly in patients with comorbidities with respiratory symptoms. |
|
Factors Associated with COVID-Related Mortality: the Case of Texas |
Ojinnaka, CO, Adepoju, et al |
J Racial Ethn Health Disparities |
Epidemiology| Épidémiologie |
The objective of this study was to explore the relationship between county-level race/ethnic composition and COVID-19
mortality in the state of Texas. Counties with higher rates of minorities, specifically Hispanics and African Americans, have a higher COVID-19 fatality burden. |
|
Olivieri, JG, de España, et al |
J Endod |
Mental Health |
|
OBJECTIVES: To assess general anxiety levels in endodontists and dental assistants related to different conditions
during the pandemic and lockdown, and to evaluate hemodynamic changes in endodontists' heart rate, blood pressure, and blood oxygenation during their workday. METHODS: Anxiety levels in endodontists and dental assistants were recorded weekly during the state
of alarm declared due to the COVID-19 pandemic. Hemodynamic parameters were monitored using a sphygmomanometer for HR and blood pressure, and a pulse oximeter for SpO(2). Measurements were taken before and after each root canal treatment, as well as on arrival
at the clinic and at the end of the working day. Rest data, recorded every Saturday, served as a control. Data analysis was performed using X(2) and paired T-Tests, Mann-Whitney, and ANOVA tests (p < 0.05). RESULTS: General anxiety decreased over the weeks,
with significant differences between weeks one and four (p < 0.05). Endodontists perceived higher anxiety levels of anxiety during anesthesia inoculation and dental assistants during the dental unit's disinfection and equipment material (p < 0.05). There was
a significant increase in the cardiovascular response in all endodontists in the clinic registrations compared with rest data (p < 0.05). Values were higher in the strict confinement period and significant for HR when arriving at the clinic (p < 0.05). CONCLUSIONS:
Levels of general anxiety were higher during the first weeks. The chief perceived factors related to anxiety in endodontists and dental assistants were the risk of contagion and protection measures. Higher HR and blood pressure levels were registered during
the workday, especially when arriving at the clinic. |
|
|
O'Malley, G, Ebekozien, et al |
J Clin Endocrinol Metab |
Clinical data| Données cliniques |
The objective of this study was to analyze characteristics of adults with type 1 diabetes for associations with COVID-19
hospitalization. Baseline glycemic control and access to care are important modifiable risk factors which need to be addressed to optimize care of people with type 1 diabetes during the worldwide COVID-19 pandemic. |
|
|
Oostvogels, Lidia, Kremsner, et al |
medRxiv |
Coronavirology| Coronavirologie |
Authors have applied an mRNA-based technology platform, RNActive®, to develop CVnCoV which contains sequence optimized
mRNA coding for a stabilized form of S protein encapsulated in lipid nanoparticles (LNP). Preliminary results in the subset of subjects who were enrolled with known SARS-CoV-2 seropositivity at baseline show that CVnCoV is also safe and well tolerated in this
population, and is able to boost the pre-existing immune response even at low dose levels. |
|
|
Østergaard, L, Butt, et al |
Am Heart J |
Healthcare Response | Réponse des soins de santé |
We aimed to examine the incidence of acute coronary syndrome (ACS), after national lock-down by comparing the incidence
to a prior period (2017-2019). Results find that during the COVID-19 pandemic with an established national lock-down we identified a significant decline around 30% in the incidence of ACS admissions. Along with the reopening of society, ACS admissions were
stabilized at levels equal to previous years. |
|
|
Chest CT in the emergency department for suspected COVID-19 pneumonia |
Palmisano, A, Scotti, et al |
Radiol Med |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Here we report the diagnostic role of CT in two emergency departments (EDs) in Lombardy, epicenter of Italian outbreak.Most
of cases (96/142, 68%) were classified as “highly likely” COVID-19 pneumonia. Ten (7%) and seven (5%) patients were classified as “likely” and “unlikely” COVID-19 pneumonia, respectively. In 21 (15%) patients a differential diagnosis was provided, including
typical pneumonia, pulmonary edema, neoplasia, and pulmonary embolism. CT was negative in 8/142 (6%) patients. CT performance was good with 76% specificity, 99% sensitivity, 90% positive predictive value and 97% negative predictive value. |
|
Pan, J, St Pierre, et al |
Int J Environ Res Public Health |
Epidemiology| Épidémiologie |
This study aims to identify factors that may explain the variation in case fatality rate (CFR) across countries. Across
the 39 countries under consideration, our model shows COVID-19 case fatality rate was best predicted by time to implementation of social distancing measures, hospital beds per 1000 individuals, percent population over 70 years, CT scanners per 1 million individuals,
and (in countries with high population density) smoking prevalence. |
|
|
Pandolfi, Laura, Bozzini, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
The aim of this in vitro study is to assess the capacity of neutrophil extracellular traps (NETs) to drive epithelial-mesenchymal
transition (EMT) of lung epithelial cells and to analyze the involvement of NETs in COVID-19. Co-culturing A549 at air-liquid interface with alveolar macrophages, neutrophils and SARS-CoV2, we demonstrated a significant induction of the EMT in lung epithelial
cell lines (A549) together with high concentration of NETs, IL8 and IL1β, best-known inducers of NETosis. Lung tissues of COVID-19 deceased patients showed that epithelial cells are characterized by increased mesenchymal markers. These results show for the
first time that NETosis plays a major role in triggering lung fibrosis in COVID-19 patients |
|
|
Paolo, G, Stefano, et al |
J Allergy Clin Immunol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this retrospective multicentre study was to investigate the incidence of hospitalization and death
for COVID-19 in a large sample of patients with plaque psoriasis receiving biologic therapies compared with the general population in Italy. Our data did not show any adverse impact of biologics on COVID-19 outcome in psoriasis patients. We would not advise
biologic discontinuation in patients on treatment since more than 6 months and not infected with SARS-CoV-2 to prevent hospitalization and death from COVID-19. |
|
|
Parisi, Nicolas, Mili, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This monocentric retrospective cohort study sought to set up simple and reliable predictive scores for intensive care
admissions and deaths in COVID-19 patients and compare against a benchmark value (Liang score). Our results suggest that Liang score may not provide reliable guidance for ICU admission and death. Moreover, the performance of this approach is clearly outperformed
by models based on simple markers. For example, a logistic regression considering only the LDH yields to similar sensitivity and greater specificity. Finally, all models considered in this study lead to levels of specificity under or equal to 50%. |
|
|
Paul, G, Sharma, et al |
Journal of Anaesthesiology Clinical Pharmacology |
Healthcare Response | Réponse des soins de santé |
We aimed to evaluate knowledge and perceptions about COVID-19 among the health care workers (HCWs) as well as general
public participants (GPPs). The 1,026 responses comprised of 558 HCWs (54.4%) and 468 GPPs (45.6%). The most reliable source of information was TV news for 43% GPPs, whereas it was HCWs/Local health authorities for 36.8% HCWs. HCWs had sufficient knowledge
regarding COVID-19, while it was relatively low among GPPs (average correct response 65% and 53%, respectively). Intra-group analysis with respect to age, sex, qualification, and socioeconomic status showed that knowledge about mode of transmission by airborne
aerosols was significantly low with respect to qualification among GPPs while younger age group (<40 years) HCWs had significantly more knowledge about mode of transmission and asymptomatic carriers. Paranoia of contracting the infection was significantly
higher in GPPs with upper and middle socioeconomic status and younger HCWs. |
|
|
Peng, Bo, Zhou, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
We performed extensive simulations to evaluate the performance of quarantine strategies with one or more tests administered
during quarantine in order to assess a test result based quarantine period. Sensitivity analyses were performed to evaluate the impact of perturbations in model assumptions on the determination of optimal strategies. We found that SARS-CoV-2 testing can effectively
reduce the length of quarantine without compromising personal or public safety. Whereas a single RT-PCR test performed before the end of quarantine can reduce the duration of quarantine to 10 days, two tests can further reduce the duration to 8-days and three
tests with a highly sensitive RT-PCR test can justify a 6-day quarantine. More strategic testing schedules and one more day of quarantine are needed if tests are administrated with a less sensitive but more cost-effective antigen test. |
|
|
Risk factors for redetectable positivity in recovered COVID-19 children |
Peng, D, Zhang, et al |
Pediatr Pulmonol |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
The objective of this retrospective study was to identify the risk factors for redetectable positivity (RP), and to
provide a basis for prevention and control of coronavirus disease‐2019 (COVID‐19) in children. Results find that family cluster infection, higher WBC count, and longer PT are the early risk factors for RP in recovered COVID‐19 children. The dynamic changes
in number and ratio of CD4+ and CD8+ T lymphocytes may be involved in prolonged SARS‐CoV‐2 clearance. |
|
Changes of Humoral Immunity Response in SARS-CoV-2
Convalescent Patients over 8 months |
Peng, Pai, Hu, et al |
medRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
Here, we reported changes of antibodies against SARS-CoV-2 in convalescent patients over 8 months. Antibodies of all
20 participants targeting SARS-CoV-2 spike receptor binding-domain (RBD) had decreased from a mean OD450 value 1.78 to 0.38 over 8 months. The neutralizing antibody (NAb) titers decreased from the mean ID50 value 836 to 170. The NAb titers were significantly
correlated with IgG level during 8 months (P<0.001). Furthermore, while RBD-specific IgG existence of 25% (5/20) convalescent plasma was undetectable, the NAb titers of 15% (3/20) convalescent plasma decreased below the threshold. In addition, compared to
wild-type SARS-CoV-2 (S-D614), lower titers of neutralizing antibodies against its G614 variant were shown at 8 months after symptom onset. |
|
Peng, X, Chen, et al |
Int J Diabetes Dev Ctries |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Here, we investigated the clinical features of critically ill SARS-CoV-2 patients with and without diabetes and identified
risk factors for death of these patients. Results indicate that critically ill COVID patients with Type 2 diabetes had more severe damages of the lymphocytes, islet cells, and heart function, and gastrointestinal symptoms, lymphopenia, and increased FBG may
be early predictors for poor prognosis. |
|
|
Petermann-Rocha, F, Hanlon, et al |
BMC Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to compare the association between frailty and severe COVID-19 infection in UK Biobank (n=383,845)
using two frailty classifications: the frailty phenotype and the frailty index. Of UK Biobank participants included, 802 were admitted to hospital with and/or died from COVID19 (323 deaths and 479 hospitalisations). After analyses were adjusted for sociodemographic
and lifestyle factors, a higher risk of COVID-19 was observed for pre-frail (risk ratio (RR) 1.47 [95% CI 1.26; 1.71]) and frail (RR 2.66 [95% CI 2.04; 3.47]) individuals compared to those classified as robust using the frailty phenotype. Similar results were
observed when the frailty index was used (RR mildly frail 1.46 [95% CI 1.26; 1.71] and RR moderate/severe frailty 2.43 [95% CI 1.91; 3.10]). |
|
|
Porritt, RebeccaA, Paschold, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
Here, we characterized the TCR repertoire of Multisystem Inflammatory Syndrome in Children (MIS-C) patients and found
a profound expansion of TCR Beta Variable gene (TRBV)11-2. Furthermore, TRBV11-2 skewing was remarkably correlated with MIS-C severity and serum cytokine levels. Further analysis of TRBJ gene usage and CDR3 length distribution of MIS-C expanding TRBV11-2 clones
revealed extensive junctional diversity, indicating a superantigen-mediated selection process for TRBV expansion. In silico modelling indicates that polyacidic residues in TCR Vβ11-2 engage in strong interactions with the superantigen-like motif of SARS-CoV-2
spike glycoprotein. Overall, our data indicate that the immune response in MIS-C is consistent with superantigenic activation. |
|
|
Posfay-Barbe, K, Andrey, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In a sample of 208 children seeking medical care, seropositivity rate of anti-SARS-CoV-2 IgG antibodies was 8.7%, suggesting
a similar infection rate to that observed in adults, but >100-fold the incidence of RT-PCR-confirmed pediatric cases. Compared to the gold-standard combined ELISA+immunofluorescence, the MEDsan IgG rapid diagnostic test performed accurately. |
|
|
Qi, Xiao, Brown, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this study, we design a novel multi-feature convolutional neural network (CNN) architecture for multi-class improved
classification of COVID-19 from CXR images. CXR images are enhanced using a local phase-based image enhancement method. The enhanced images, together with the original CXR data, are used as an input to our proposed CNN architecture. Using ablation studies,
we show the effectiveness of the enhanced images in improving the diagnostic accuracy. We provide quantitative evaluation on two datasets and qualitative results for visual inspection. Quantitative evaluation is performed on data consisting of 8,851 normal
(healthy), 6,045 pneumonia, and 3,323 Covid-19 CXR scans. In Dataset-1, our model achieves 95.57% average accuracy for a three classes classification, 99% precision, recall, and F1-scores for COVID-19 cases. For Dataset-2, we have obtained 94.44\% average
accuracy, and 95% precision, recall, and F1-scores for detection of COVID-19. |
|
|
SARS- CoV-2 infection presented as acute exacerbation of bronchial Asthma |
Raina, P, Baidya, et al |
Journal of Anaesthesiology Clinical Pharmacology |
Clinical data| Données cliniques |
The varied presentation of acute respiratory illness from SARS-CoV-2 poses a diagnostic challenge to the physician.
The classic presentation of fever, cough and shortness of breath is often not reported in a number of patients. We report a case of acute respiratory illness in a middle-aged asthmatic man who presented with acute severe bronchospasm. |
|
Rameez, F, McCarthy, et al |
Cerebrovasc Dis Extra |
Healthcare Response | Réponse des soins de santé |
Our study aims to evaluate the impact of a stay-at-home order on stroke metrics during the 2019-novel coronavirus (COVID-19)
pandemic in West Michigan, USA. Our study demonstrated a reduction in cases of acute ischemic stroke (AIS), although this did not reach statistical significance. However, there was an increase in hemorrhagic stroke (7.5% controls vs. 19.2% study group). The
age of stroke patients was significantly younger during the period of the stay-at-home order compared to the control group. We identified a significant overall delay of ED arrivals from LKW in the study group. Additionally, an increased number of AIS patients
with LVO in the study group (34.8%) was found compared to the control group (17.5%). A significantly increased number of patients received MT in the study group. |
|
|
Optimization and Evaluation of Propolis liposomes as a promising therapeutic
approach for COVID-19 |
Refaat, H, Mady, et al |
Int J Pharm |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The present docking study aimed to develop an optimized liposomal formulation for enhancing the anti-viral activity
of propolis against COVID-19. Response surface methodology and modified injection method were implemented to maximize the entrapment efficiency and release of the liposomal formulation. Docking studies revealed that Rutin and Caffeic acid phenethyl ester showed
the highest affinity to both targets. Results showed a significant inhibitory effect of the optimized liposomal formula of Propolis against COVID-3CL protease (IC50 = 1.183 ± 0.06) compared with the Egyptian propolis extract (IC50 = 2.452 ± 0.11), P < 0.001.
Interestingly, the inhibition of viral replication of COVID-19 determined by RT_PCR has been significantly enhanced via encapsulation of propolis extract within the liposomal formulation (P < 0.0001) and was comparable to the viral inhibitory effect of the
potent antiviral (remdesivir). |
|
COVID-19 Patient Detection from Telephone Quality Speech Data |
Ritwik, Kotra Venkata Sai, Kalluri, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Diagnostics / Pathogen detection| Diagnostics
/ Détection d'agents pathogènes |
In this paper, we try to investigate the presence of cues about the COVID-19 disease in the speech data. We use an
approach that is similar to speaker recognition. Each sentence is represented as super vectors of short term Mel filter bank features for each phoneme. These features are used to learn a two-class classifier to separate the COVID-19 speech from normal. Experiments
on a small dataset collected from YouTube videos show that an SVM classifier on this dataset is able to achieve an accuracy of 88.6% and an F1-Score of 92.7%. Further investigation reveals that some phone classes, such as nasals, stops, and mid vowels can
distinguish the two classes better than the others. |
|
Robinson, Carolyn-Ann, Kleer, et al |
bioRxiv |
Coronavirology| Coronavirologie |
To contribute to an enhanced understanding of how SARS-CoV-2 and other CoVs usurp cellular antiviral responses and
alter cytokine mRNA expression profiles, we performed an analysis of processing bodies (PBs). Our results show that several SARS-CoV-2 gene products also mediate PB loss and virus-induced PB loss correlates with elevated levels of proinflammatory cytokine
mRNAs that would normally be repressed in PBs. |
|
|
In-hospital
outcomes of patients with ST-segment elevation myocardial infarction and COVID-19 |
Rodriguez-Leor, O, Cid Alvarez, et al |
EuroIntervention |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to assess clinical and prognosis differences in patients with Covid-19 and STEMI using
a nationwide registry of consecutive patients. Our study revealed a significant increase in in-hospital, stent thrombosis and cardiogenic shock development after PCI in patients with STEMI and Covid-19 in comparison with contemporaneous non-Covid-19 STEMI
patients. |
|
Immunohistochemical Study of SARS-CoV-2 Viral Entry Factors in the Cornea and
Ocular Surface |
Roehrich, H, Yuan, et al |
Cornea |
Transmission Clinical data| Données cliniques |
The aim of this study was to confirm the ocular tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
by evaluating the expression of viral entry factors in human ocular tissues using immunohistochemistry. Results from the five donor corneas find that both corneal and conjunctival epithelia express ACE2, DC-SIGN/DC-SIGNR, and TMPRSS2, suggesting that the ocular
surface is a potential route for the transmission of SARS-CoV-2. The risk of viral transmission with corneal transplantation cannot be ruled out, given the presence of ACE2 in corneal epithelium and endothelium. |
|
Roma, P, Monaro, et al |
Int J Environ Res Public Health |
Mental Health |
|
The present study aimed at identifying psychological changes (e.g., changes in depression, stress, and anxiety levels)
among the Italian public during the lockdown period, in addition to factors associated with these changes. Results showed an increase in stress and depression over the lockdown, but not anxiety. Negative affect and detachment were associated with higher levels
of depression and stress. Higher levels of depression at the start of the lockdown, as well as fewer coping strategies and childlessness, were associated with increased depression at follow-up, whereas higher levels of stress at the start of the lockdown and
younger age were associated with higher stress at follow-up. |
|
|
Turn down of acute aortic syndrome cases during COVID-19: Results from UK multicentre studies |
Roman, M, Harky, et al |
J Card Surg |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to establish if patients affected by acute aortic syndrome (AAS) had unrestricted access
to emergency treatment and evaluate outcome of these patients during the peak of the pandemic. Among 95 patients who presented with an AAS in the participating centers; 85 (89%) underwent surgery, 7 (7%) were turned down for surgery because of their profile
of comorbidities, and 3 (3%) died on transfer. Among the patients treated conservatively, three of them (43%) were alive at 30 days. We observed no significant restriction in access to treatment for AAS during the early months of the pandemic. |
|
Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers |
Rosenke, K, Leventhal, et al |
J Antimicrob Chemother |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Peptide-conjugated morpholino oligomers (PPMO) are antisense compounds composed of a phosphorodiamidate morpholino
oligomer covalently conjugated to a cell-penetrating peptide. Five PPMO designed against sequences of genomic RNA in the SARS-CoV-2 5′-untranslated region and a negative control PPMO of random sequence were synthesized. The data indicate that PPMO have the
ability to potently and specifically suppress SARS-CoV-2 growth and are promising candidates for further preclinical development. |
|
COVID-19 pandemic effect on early pregnancy: are miscarriage rates altered, in
asymptomatic women? |
Rotshenker-Olshinka, K, Volodarsky-Perel, et al |
Arch Gynecol Obstet |
Healthcare Response | Réponse des soins de santé |
A retrospective cohort study conducted at a university-affiliated fertility center in Montreal, Quebec, since the COVID-19
shut down, March 13 until May 6, 2020. This study aims to evaluate the effect of the COVID-19 pandemic state on early, first-trimester pregnancies. The COVID-19 pandemic environment does not seem to affect early first-trimester miscarriage rates in asymptomatic
patients. |
|
Roy, C, Mandal, et al |
Genomics |
Coronavirology| Coronavirologie |
SARS-CoV-2 microevolution was studied alongside the global trends of point-mutation in a universal dataset of 71,703
genomes. Globally, nsp1/nsp2 and orf7a/orf3a were the most mutation-ridden non-structural and structural genes respectively. Whole-genome phylogeny revealed that entities belonging to the early lineages are mostly spread over Asian countries (including India)
whereas the recently-derived lineages are more globally distributed. A transition: transversion ratio of 2.66 characterized the nucleotide substitution bias of SARS-CoV-2, with cytidine-to-uridine and guanosine-to-uridine conversions being the predominant
transition and transversion types respectively. In the pan-genome, cytidine-to-uridine mutations yielding nonsynonymous amino acid replacements have a propensity for changing hydrophilic residues to hydrophobic ones. Nonsynonymous mutations are under positive
selection in most of the structural, but not non-structural, genes. |
|
|
Saha, O, Hossain, et al |
Gene Rep |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Viral strains found in Bangladesh mainly came from multiple countries such as France, Germany, India, USA and Brazil.
Intra-cluster, and inter-cluster start to circulate in the 8 individual divisions of Bangladesh. 26 parsimony-informative sites along with 256 mutations were found in the circulating strains. Nine deletions throughout the genomes including in ORF7a (8), ORF8
(1). |
|
|
Salin, M, Kaittila, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
This study aims to examine how families with children coped during the COVID-19 lockdown in Finland. An online survey
including both qualitative and quantitative questions April and May 2020. Finnish families employed coping strategies on three levels: macroenvironmental, relationship, and individual. |
|
|
Pulmonary vascular improvement in severe COVID-19 patients treated with tocilizumab |
Salvati, L, Occhipinti, et al |
Immunol Lett |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
retrospective observational study, 20 severe COVID-19 patients were treated with tocilizumab in addition to standard-of-care
therapy (SOC) and compared with 13 COVID-19 patients receiving only SOC. Clinical respiratory status, inflammatory markers and vascular radiologic score improved after one week from tocilizumab administration--> parameters were stable or worsened in patients
receiving only SOC. |
|
Sangal, RB, Wrzesniewski, et al |
BMJ Leader |
Mental Health |
|
We conducted repeated cross-sectional surveys embedded within emergency department workflow to understand whether team
identification was associated with reduced reports of stress and burnout among front-line workers. Higher team identification was associated with significantly less work stress (B=−0.60, 95% CI −0.84 to to -0.40, p<0.001) and burnout (B=−12.87, 95% CI −17.73
to -8.02, p<0.001) in cross-sectional analyses. Further evidence of the protective effect of team identification for work stress (B=−0.36, 95% CI −0.76 to 0.05, p=0.09) and burnout (B=−13.25, 95% CI −17.77 to -8.73, p<0.001) was also found in prospective longitudinal
evidence. |
|
|
Detecting Emerging Symptoms of COVID-19 using Context-based Twitter Embeddings |
Santosh, Roshan, Schwartz, et al |
arXiv |
Public Health response| Interventions de santé publique |
In this paper, we present an iterative graph-based approach for the detection of symptoms of COVID-19, the pathology
of which seems to be evolving. More generally, the method can be applied to finding context-specific words and texts (e.g. symptom mentions) in large imbalanced corpora (e.g. all tweets mentioning #COVID-19). Given the novelty of COVID-19, we also test if
the proposed approach generalizes to the problem of detecting Adverse Drug Reaction (ADR). We find that the approach applied to Twitter data can detect symptom mentions substantially before being reported by the Centers for Disease Control (CDC). |
|
Sarı, C, Şimşek, et al |
J Hum Hypertens |
Healthcare Response | Réponse des soins de santé |
This study was designed to assess the practice behaviors of physicians toward hypertension treatment with ACE-i or
ARBs during the COVID-19 pandemic. Of the total respondents, 78.7% reported that they had not changed their antihypertensive medication prescribing pattern, 8.6% of clinicians had changed ACE-i/ ARBs medicine of patients during the COVID-19 pandemic and 12.7%
of them were undecided. |
|
|
Sasaki, N, Kuroda, et al |
J Epidemiol |
Mental Health |
|
We investigate psychological distress among employees with low socioeconomic status (SES) in Tokyo , Japan. People
of low SES, especially those with low education, maybe be at an increased risk of infection and psychological stress. They have several factors that increase their exposure to COVID-19. In this cohort, low education workers likely belong to smaller companies,
which have been shown to implement less preventive measures for COVID-19. Besides the infection, they may experience the psychological burden, such as the negative economic effects of COVID-19 control measures (i.e., temporary forced to leave or to reduce
an employee's hours of work) on the household due to their unstable work conditions, the harassment related to COVID-19, and fewer social resources. In Japan, low education attainment predicts the risk of suicide. |
|
|
Inference under Superspreading: Determinants of SARS-CoV-2 Transmission in Germany |
Schmidt, PatrickW |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
The author proposed a model for aggregated case data that accounts for superspreading and improves statistical inference.
In a Bayesian framework, the model is estimated on German data featuring over 60,000 cases with date of symptom onset and age group. Several factors were associated with a strong reduction in transmission: public awareness rising, testing and tracing, information
on local incidence, and high temperature. Immunity after infection, school and restaurant closures, stay-at-home orders, and mandatory face covering were associated with a smaller reduction in transmission. The data suggests that public distancing rules increased
transmission in young adults. Information on local incidence was associated with a reduction in transmission of up to 44% (95%-CI: [40%, 48%]), which suggests a prominent role of behavioral adaptations to local risk of infection. Testing and tracing reduced
transmission by 15% (95%-CI: [9%,20%]), where the effect was strongest among the elderly. Extrapolating weather effects, I estimate that transmission increases by 53% (95%-CI: [43%, 64%]) in colder seasons. |
|
Self, WH, Semler, et al |
JAMA |
Therapeutics| Thérapeutique RCT |
This multicenter, blinded, placebo-controlled randomized trial conducted at 34 hospitals in the US, investigates whether
treatment with hydroxychloroquine improve clinical outcomes of adults hospitalized with coronavirus disease 2019 (COVID-19). 479 hospitalized adults , the distribution of the day 14 clinical status score (measured using a 7-category ordinal scale) was not
significantly different for patients randomized to receive hydroxychloroquine compared with placebo (adjusted odds ratio, 1.02). These findings do not support the use of hydroxychloroquine for treatment of COVID-19 among hospitalized adults. |
|
|
Selhorst, Philippe, van Ierssel, et al |
medRxiv |
Epidemiology| Épidémiologie Transmission |
A case of re-infection was observed in a Belgian nosocomial outbreak involving 3 patients and 2 health care workers.
Re-infection (after 185d) was confirmed in a young, immunocompetent health care worker as viral genomes derived from the first and second episode belonged to different SARS-CoV-2 clades. The second episode, however, was milder and characterized by a fast rise
in serum IgG and neutralizing antibodies. |
|
|
An itchy erythematous papular skin rash as a possible early sign of COVID-19: a
case report |
Serafini, A, Kurotschka, et al |
J Med Case Rep |
Clinical data| Données cliniques |
An Italian 32-year-old female nurse had several close contacts with multiple patients with COVID-19 as part of her
professional workload. On March 13, 2020, the patient developed an itchy, erythematous papular rash (sparing only her face, scalp, and abdomen), which lasted for 10 days. The rash was accompanied by a feeling of general fatigue that gradually worsened over
the following days and has continued for 5 months (until the end of July 2020). During the first week of remote assessment carried out by her general practitioner, the patient gradually developed a dry cough, intermittent fever, and diarrhoea and then had
a positive test result for SARS-CoV-2. Her skin manifestations disappeared completely 48 days after the onset of the disease, followed by the disappearance of the dry cough. |
|
Shafi, K, Lovecchio, et al |
HSS Journal |
Healthcare Response | Réponse des soins de santé |
Authors sought to evaluate patient satisfaction with telehealth visits as a platform for delivering care for the treatment
of spinal pathology. Eighty-four patients responded to the survey. Their attitudes were largely positive, with an overall mean patient satisfaction score of 4.79. Patients gave high scores for clarity of communication during the visit, and for satisfaction
with the formulation of treatment plans and their ability to ask questions, they gave the lowest scores to the effectiveness of telemedicine in replacing an in-person visit and ease of interface navigation. |
|
|
PMC7641593; Factors associated with increased mortality in hospitalized COVID-19
patients |
Shah, C, Grando, et al |
Ann Med Surg (Lond) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we identified several risk factors that are associated with increased mortality in COVID-19 patients.
A higher proportion of patients were age 65 and older (87.76% vs 53.24%, p < 0.001), and were predominantly male (63.27% vs 52.94%, p = 0.0351). Multivariate analysis showed five variables to be the predictors for mortality: age ≥65 [OR = 3.87, 95% CI (2.01,
7.46), p < 0.001], initial presentation with dyspnea [OR = 1.71, 95% CI (1.03, 2.82), p = 0.037], history of cardiomyopathy [OR = 3.33, 95% CI (1.07, 10.41), p < 0.038], positive initial chest imaging findings [OR = 2.24, CI (1.26, 3.97), p = 0.006], and acute
kidney injury (AKI) [OR = 3.33 CI (2.10, 5.28), P < 0.001]. |
|
Shahbaznejad, L, Navaeifar, et al |
BMC Pediatr |
Clinical data| Données cliniques Long-Term Sequelae |
|
The purpose of this report was to describe the possible association between COVID-19 and PIMS in children. Findings
show that children with COVID-19 may present symptoms similar to Kawasaki disease and inflammatory syndromes. PIMS should be considered in children with fever, rash, seizure, cough, tachypnea, and gastrointestinal symptoms such as vomiting, diarrhea, and abdominal
pain. |
|
|
Comparison of chest ultrasound and standard X-ray imaging in COVID-19 patients |
Shumilov, E, Hosseini, et al |
Ultrasound International Open |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We aimed to investigate patterns of ChUS in COVID-19 patients and compare the findings with results from chest X-ray
(CRX). 24 patients (18 symptomatic, 6 asymptomatic) with confirmed SARS-CoV-2 by polymerase chain reaction underwent bedside ChUS in addition to CRX following admission. 94% (n=17/18) of patients with respiratory symptoms demonstrated lung abnormalities on
ChUS. ChUS was especially useful to detect interstitial syndrome compared to CXR in COVID-19 patients (17/18 vs. 11/18; p<0.02). |
|
Sousan, S, Garcia, et al |
Am J Infect Control |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
The purpose of this study was to assess the efficiency of the Halyard H600 as a respirator filtering material as compared
to the NIOSH-certified N95 and P100 filters, and determine if H600 is a good alternative for respiratory protection for healthcare professionals during the COVID-19 pandemic. The high variability in filter efficiency for particles ≤324 nm and the increased
fabric breathing resistance demonstrate that the Halyard H600 has an inferior performance and is not a good substitute for N95 and P100. |
|
|
Virucidal efficacy of different formulations for hand
and surface disinfection targeting SARS CoV-2 |
Steinhauer, Katrin, Meister, et al |
bioRxiv |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
This study demonstrates that two commercially available formulations for surface disinfection and one formulation for
hand disinfection claiming “virucidal activity against enveloped viruses” are effectively inactivating SARS-CoV-2. This study emphasizes that chemical disinfectants claiming “virucidal activity against enveloped viruses” are an effective choice to target enveloped
SARS-CoV-2 as a preventive measure. |
|
Sterling, RK, Oakes, et al |
J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The Fibrosis-4 Index (FIB-4), developed to predict fibrosis in liver disease, was used to identify patients with coronavirus
disease 2019 who will require ventilator support as well as those associated with 30-day mortality. Multivariate analysis found obesity (odds ratio [OR], 4.5), diabetes mellitus (OR, 2.55), and FIB-4 ≥2.67 (OR, 3.09) independently associated with need for
mechanical ventilation. |
|
|
Submitter, Melbourne Institute, Hassink, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique Economics | Économie |
We explore the impact of COVID-19 hotspots and regional lockdowns on the Dutch labour market. The results suggest individual
characteristics are more important, including the employee’s age, type of contract and type of job. The evidence suggests that the decline of the labour market was all due to the impacts from the government-enforced lockdown and higher virus case numbers did
not reinforce this decline. This suggests that preventive health measures should be at the regional level, isolating hotspots from low-risk areas. |
|
|
Factors influencing intention to follow the “stay at home” policy during the COVID-19
pandemic |
Sumaedi, S, Bakti, et al |
International Journal of Health Governance |
Public Health response| Interventions de santé publique |
The findings show that attitude towards the behavior, subjective norm and perceived behavioral control positively and
significantly affect intention to follow “Stay at Home” during the COVID-19 pandemic. However, perceived susceptibility and perceived severity of COVID-19 do not significantly influence the intention to follow “Stay at Home” during the COVID-19 pandemic. |
|
Tabaac, S, Kothari, et al |
J Emerg Med |
Clinical data| Données cliniques Long-Term Sequelae |
|
This case report describes the presentation, findings, workup, and treatment for a 9-year-old boy diagnosed with multisystem
inflammatory syndrome in children (MIS-C). |
|
|
Chest CT in COVID-19 pneumonia: what are the findings in mid-term follow-up? |
Tabatabaei, SMH, Rajebi, et al |
Emerg Radiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques Long-Term Sequelae |
|
The purposes of this study are to investigate mid-term chest computed tomography (CT) findings of coronavirus disease
2019 (COVID-19) pneumonia, assess the rate of complete resolution, and determine the individuals at risk for residual abnormalities. Extensive lung involvement on initial CT, ICU admission, long duration of hospitalization, presence of underlying medical conditions,
high initial WBC count, and development of leukocytosis during the course of disease are associated with more prevalence of chronic lung sequela of COVID-19. |
|
PMC7499591; Are Seroprevalence Estimates for Severe Acute Respiratory Syndrome Coronavirus
2 Biased? |
Takahashi, S, Greenhouse, et al |
J Infect Dis |
Epidemiology| Épidémiologie |
Biased seroprevalence estimates can occur using serological assays optimized with validation sets unrepresentative
of disease spectrum in the general population. Correct interpretation of serosurveys for severe acute respiratory syndrome coronavirus 2 requires quantifying variations in sensitivity with disease severity and over time. |
|
Talmoudi, Khouloud, Safer, et al |
Research Square prepub |
Epidemiology| Épidémiologie |
We estimate serial interval (SI) and temporal reproduction number (Rt) of SARS-CoV-2 in Tunisia. |
|
|
Tang, L, Zou, et al |
Health Commun |
Public Health response| Interventions de santé publique |
Presented here is a study of how residents of Hubei Province, the epicenter of the COVID-19 outbreak in China, use
media for information seeking, scanning, and sharing while under lockdown through in-depth interviews. These findings provide insights into how individuals in China use different media for information during an unprecedented public health crisis and make sense
of the limited and often confusing and contradictory information that is available to them. |
|
|
Analysis of the Impact of Mask-wearing in Viral Spread: Implications for COVID-19 |
Tian, Yurun, Sridhar, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
In this paper, we investigate the impact of mask-wearing in spreading processes over complex networks. This is done
by studying a heterogeneous bond percolation process over a multi-type network model, where nodes can be one of two types (mask-wearing, and not-mask-wearing). We provide analytical results that accurately predict the expected epidemic size and probability
of emergence as functions of the characteristics of the spreading process (e.g., transmission probabilities, inward and outward efficiency of the masks, etc.), the proportion of mask-wearers in the population, and the structure of the underlying contact network. |
|
Tkatek, S, Belmzoukia, et al |
Work |
Public health interventions*| Interventions de sant&eacute; publique |
The objective of this work is to develop an expert system that combines several solutions to combat COVID-19. The main
solution is based on a new developed software called General Guide (GG) application. This expert system allows us to explore, monitor, forecast, and optimize the data collected in order to take an efficient decision to ensure the safety of citizens, forecast,
and slow down the spread’s rate of COVID-19. It will also facilitate countries’ interventions and optimize resources. This developed expert system can assist in stopping the spread of COVID-19 globally and putting the world back to work. |
|
|
Toor, HG, Banerjee, et al |
Eur J Pharmacol |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We implemented a drug re-purposing approach wherein the inhibitory efficacy of a cluster of thirty known drug candidates
comprising of antivirals, antibiotics and phytochemicals (selection contingent on their present developmental status in underway clinical trials) was elucidated by subjecting them to molecular docking analyses against the spike protein RBD model. Our results
indicated that Camostat, Favipiravir, Tenofovir, Raltegravir and Stavudine showed significant interactions with spike RBD of SARS-CoV-2. |
|
|
Gout, rheumatoid arthritis and the risk of death
from COVID-19: an analysis of the UK Biobank |
Topless, Ruth, Phipps-Green, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We assess whether gout and / or rheumatoid arthritis (RA) are risk factors for coronavirus disease 19 (COVID-19) diagnosis
and whether gout and / or RA are risk factors for death from COVID-19. RA and gout are not risk factors for COVID-19-diagnosis. However RA, but not gout, is a risk factor for death from COVID-19 in a population-based analysis using the UK Biobank. |
|
Tsapanou, A, Papatriantafyllou, et al |
Int J Geriatr Psychiatry |
Public Health response| Interventions de santé publique |
The aim of the current study was to analyze the impact of COVID‐19 pandemic on older adults with Mild Cognitive Impairment
(MCI)/dementia and their caregivers as well. Two hundred and four caregivers took part in the study. Results indicated a significant overall decline of the people with MCI/dementia. Further, the domains in which people with MCI/dementia were mostly affected
were: communication, mood, movement, and compliance with the new measures. Caregivers also reported a great increase in their psychological and physical burden during this period, where the available support sources were limited. |
|
|
NYU-EDA in Modelling the Effect of COVID-19 on Patient Volumes in A Finnish
Emergency Department |
Tuominen, Jalmari, Hällberg, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
We acquired a retrospective cohort containing all ED visits in a Finnish secondary care hospital during years 2018,
2019 and 2020. We compared the number of presentations in 2020 during the national state of emergency, i.e. from March 16 to June 11, with numbers from 2018 and 2019. We observed a significant reduction in total ED visits in the course of national state of
emergency. Presentations were reduced in most of the NYU-EDA groups irrespective of the assessed acuity. |
|
PMC7642739; Unilateral livedo reticularis in COVID-19 patient: Case with fatal
outcome |
Tusheva, I, Damevska, et al |
JAAD Case Rep |
Clinical data| Données cliniques |
We report a case of unilateral LR in a patient with fatal outcome, presenting initial and follow-up patient clinical
and laboratory findings. A previously healthy 59-year-old female presented with an eight-day history of dry cough, mild dyspnea, and a low-grade fever. |
|
Association Between the COVID-19 Outbreak and Mental Health in India: A Google Trends
Study |
Uvais, NA |
Prim Care Companion CNS Disord |
Mental Health |
|
The objective of this study was to use the Google Trends search volume index (SVI), a normalized value from 0 to 100,
to understand whether changes in the number of COVID-19 cases and deaths are associated with SVI of contents associated with mental health in India. There were significant positive correlations between the SVI for all keywords in English and the number of
COVID-19 cases and deaths in India: depression, anxiety, insomnia, and suicide. Moreover, there were a higher number of searches for the terms suicide and depression compared to other search terms. |
|
Vechyorko, VI, Evsikov, et al |
Profilakticheskaya Meditsina |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The purpose of the study is to assess the available treatment methodologies, physical and psychological rehabilitation
in patients (men and women) with a viral infection COVID-19 in 2020, complicated by viral pneumonia, who underwent inpatient treatment in the therapeutic department of the city clinical hospital No. 15 named after. O. M. Filatov DZM. There were slight gender
differences: the maximum number (51.5%) of cases of pneumonia of the 2nd degree of severity was observed in men, and in women, pneumonia of the 1st degree was encountered with the highest frequency (48.2%). |
|
|
Mood of India during Covid-19 - An interactive web portal based on emotion analysis
of twitter data |
Venigalla, ASM, Chimalakonda, et al |
|
Public Health response| Interventions de santé publique |
We present a web portal that aims to display mood of India during Covid-19, based on real time twitter data. As of
25 June 2020, the web portal has about 703618 tweets, and each of these tweets are classified into seven categories that include six basic emotions and a neutral category. |
|
Venuleo, Claudia, Marino, et al |
Research Square prepub |
Mental Health |
|
The current study aims to show whether internet worked as a resource for well-being or as an amplifier of psychological
distress and problematic internet use (PIU), considering the role of gender, age, motives for using the internet and online/offline relational resources. Five hundred and seventy-three adult participants (M: 40.28; SD: 16.43; 64% women) completed a form on
sociodemographic characteristics and Internet use, and completed standardized measures on loneliness, online social support, well-being and PIU. Differences were found in the likelihood of PIU and well-being related to all the variables considered, with the
exception of online social support for PIU and gender and age for well-being. These findings call for further research aimed to disentangle the correlates of PIU in a time of physical distancing, as well as for innovative efforts tailored to blunt the impacts
of social isolation and bolster social connectivity. |
|
|
Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy |
Wacker, A, Weigand, et al |
Nucleic Acids Res |
Coronavirology| Coronavirologie |
Here, we report the characterization of 15 conserved RNA elements located at the 5' end, the ribosomal frameshift segment
and the 3'-untranslated region (3'-UTR) of the SCoV2 genome, their large-scale production and NMR-based secondary structure determination. The NMR data are corroborated with secondary structure probing by DMS footprinting experiments. The close agreement of
NMR secondary structure determination of isolated RNA elements with DMS footprinting and NMR performed on larger RNA regions shows that the secondary structure elements fold independently. The NMR data reported here provide the basis for NMR investigations
of RNA function, RNA interactions with viral and host proteins and screening campaigns to identify potential RNA binders for pharmaceutical intervention. |
|
Waisberg, DR, Abdala, et al |
Liver Transpl |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We read with interest Massoumi et al.'s article((1)) regarding 5 patients who developed coronavirus disease 2019 (COVID-19)
in the early postoperative period of liver transplantation (LT). None of them exhibited severe disease and they all fully recovered, suggesting that COVID-19 in the early postoperative period of LT might not be associated with unfavorable outcomes. Here, we
share our experience with 7 cases, which was not so promising. |
|
|
Walk, Jona, Dofferhoff, et al |
medRxiv |
Clinical data| Données cliniques |
Vitamin K deficiency was recently found to associate with clinical outcome in a cohort of COVID-19 patients. Vitamin
D has been hypothesized to reduce disease susceptibility by modulating inflammation, yet little is known about its role in disease severity. Considering the critical interaction between vitamin K and vitamin D in calcium and elastic fiber metabolism, we determined
vitamin D status in the same cohort of 135 hospitalized COVID-19 patients by measuring blood 25(OH)D levels. We found no difference in vitamin D status between those with good and poor outcome (defined as intubation and/or death). Instead, we found vitamin
D sufficient persons (25(OH)D >50 nmol/L) had accelerated elastic fiber degradation compared to those with mild deficiency (25(OH)D 25-50 nmol/L). Based on these findings, we hypothesize that vitamin D might have both favorable anti-inflammatory and unfavorable
pro-calcification effects during COVID-19 and that vitamin K might compensate for the latter. |
|
|
Wang, A, Chiou, et al |
Elife |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
Here, we present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-nucleus transcriptomes
of 46,500 nuclei in non-diseased lung from donors of ~30 weeks gestation, ~3 years and ~30 years. We mapped candidate cis-regulatory elements (cCREs) and linked them to putative target genes. We identified distal cCREs with age-increased activity linked to
SARS-CoV-2 host entry gene TMPRSS2 in alveolar type 2 cells which had immune regulatory signatures and harbored variants associated with respiratory traits. At the 3p21.31 COVID-19 risk locus, a candidate variant overlapped a distal cCRE linked to SLC6A20,
a gene expressed in alveolar cells and with known functional association with the SARS-CoV-2 receptor ACE2. Our findings provide insight into regulatory logic underlying genes implicated in COVID-19 in individual lung cell types across age. |
|
|
Wang, Gang, Luo, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study was conducted to investigate the differences in the epidemiological and clinical characteristics of patients
with COVID-19 between the epicenter and peripheral areas of pandemic. The Sichuan & Wuhan Collaboration Research Group for COVID-19 established two retrospective cohorts that separately reflect the epicenter and peripheral area during the early pandemic. The
epidemiology, clinical characteristics and outcomes of patients in the two groups were compared. The Wuhan (epicenter) cohort included 710 randomly selected patients, and the peripheral (Sichuan) cohort included 474 consecutive patients. The worse outcomes
in the epicenter could be explained by the prolonged time from illness onset to hospital and ICU admission. |
|
|
Modelling the initial epidemic trends of COVID-19 in Italy, Spain, Germany, and
France |
Wang, K, Ding, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Transmission |
We applied an extended Susceptible-Exposed-Infectious-Removed (SEIR) model to fit the epidemic trend and estimated
corresponding epidemic features. The transmission rate estimates were 1.67 (95% credible interval (CrI), 1.64-1.71), 2.83 (2.72-2.85), 1.91 (1.84-1.98), and 1.89 (1.82-1.96) for Italy, Spain, Germany, and France, corresponding to the basic reproduction numbers
(R0) 3.44 (3.35-3.54), 6.25 (5.97-6.55), 4.03 (3.84-4.23), and 4.00 (3.82-4.19), respectively. We found Spain had the lowest ascertainment rate of 0.22 (0.19-0.25), followed by France, Germany, and Italy of 0.45 (0.40-0.50), 0.46 (0.40-0.52), and 0.59 (0.55-0.64).
Given the high transmissibility and high covertness of COVID-19, strict countermeasures, such as national lockdown and social distancing, were essential to be implemented to reduce the spread of the disease. |
|
Wang, QJ, Yao, et al |
BMC Infect Dis |
Clinical data| Données cliniques Immunology | Immunologie |
The aim of this study is to explore the kinetic changes in virology, specific antibody response and imaging during
the clinical course of COVID-19. This observational study enrolled 20 patients with COVID-19, who were hospitalized between January 20-April 6, 2020, in the two COVID-19 designated hospitals of Zhoushan, Zhejiang and Rushan, Shandong, China. SARS-COV-2 RNA
was positive as early as day four. It remained positive until day 55 post-onset in the sputum-throat swabs and became negative in most cases (55%) within 14 days after onset. Lymphocytopenia occurred in 40% (8/20) of patients during the peak infection period
and returned to normal at week five. The most severe inflammation in the lungs appeared in week 2 or 3 after onset, and this was completely absorbed between week 6 and 8 in 85.7% of patients. All COVID-19 patients in this study were self-limiting and recovered
well though it may take as long as 6-8 weeks. |
|
|
Westhaus, S, Weber, et al |
Sci Total Environ |
Epidemiology| Épidémiologie Surveillance |
An extensive sampling campaign, including nine municipal wastewater treatment plants, has been conducted in different
cities of the Federal State of North Rhine-Westphalia (Germany) on the same day in April 2020, close to the first peak of the corona crisis. Samples were processed and analysed for a set of SARS-CoV-2-specific genes, as well as pan-genotypic gene sequences
also covering other coronavirus types, using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Results of the RT-qPCR based gene analysis indicate the presence of SARS-CoV-2 genetic traces in different raw wastewaters. Furthermore, selected
samples have been sequenced using Sanger technology to confirm the specificity of the RT-qPCR and the origin of the coronavirus. A comparison of the particle-bound and the dissolved portion of SARS-CoV-2 virus genes shows that quantifications must not neglect
the solid-phase reservoir. This first evidence suggests that wastewater might be no major route for transmission to humans. Our findings draw attention to the need for further methodological and molecular assay validation for enveloped viruses in wastewater. |
|
|
Quantifying the Backlog of Total Hip and Knee Arthroplasty Cases: Predicting the
Impact of COVID-19 |
Wilson, JM, Schwartz, et al |
HSS Journal |
Healthcare Response | Réponse des soins de santé |
To help strategize an effective return to elective orthopedic surgery, we aimed to quantify the volume of total hip
arthroplasty (THA) and total knee arthroplasty (TKA) cases delayed across the USA and estimate the time required to care for these patients when non-urgent surgery resumes. Population-level data was used to estimate monthly THA and TKA procedural volume from
2011 to 2017. Using linear regression, we used this data to project monthly procedural volumes for 2020 to 2023. The projected national volume of delayed cases was 155,293 (mid-March through April; 95% CI 142,004 to 168,580), 260,806 (through May; 95% CI 238,658
to 282,952), and 372,706 (through June; 95% CI 341,699 to 403,709). The best- and worst-case scenarios for delayed cases were 77,646 (95% CI 71,002 to 84,290) and 372,706 (95% CI 341,699 to 403,709), respectively. The COVID-19 pandemic has generated a significant
backlog of THA and TKA procedures. |
|
Xiong, GL, Atkin, et al |
Prim Care Companion CNS Disord |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study is to report the clinical characteristics and transmission rate of coronavirus disease 2019 (COVID-19)
in a community inpatient long-term care psychiatric rehabilitation facility designed for persons with serious mental illness. This study examined a cohort of 54 residents of a long-term care psychiatric rehabilitation program from March to April 2020. Of the
residents, the primary psychiatric diagnoses were schizoaffective disorder: 28 (51.9%), schizophrenia: 21 (38.9%), bipolar I disorder: 3 (5.5%), and unspecified psychotic disorder: 2 (3.7%). Forty (74%) of 54 residents tested positive for SARS-COV-2, with
a doubling time of 3.9 days. Psychiatric and medical conditions were not significantly associated with contracting SARS-COV-2, with the exception of obesity (n = 17 43%] positive vs n = 12 86%] negative, P = .01). Research is needed to determine optimal strategies
for long-term care mental health settings that incorporate frequent testing and personal protective equipment use to prevent rapid transmission of SARS-COV-2. |
|
|
The Impact of COVID-19 Pandemic on Colorectal Cancer Patients: A Single-Center
Retrospective Study |
Xu, Yun, Huang, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
This study evaluated the impact of the pandemic on colorectal cancer (CRC) patients at our center and aimed to share
lessons learned with clinics currently experiencing this impact. We retrospectively collected data on CRC patients admitted between January 1, 2020 and May 3, 2020; the control group comprised patients admitted between January 1, 2019 and May 3, 2019. During
the pandemic, outpatient volumes decreased significantly, especially among nonlocal and elderly patients. 710 CRC patients underwent curative enterectomy. The proportion of laparoscopic surgery was 49.4%, which was significantly higher than the 39.5% patients
who received a laparoscopic surgery during the same period in 2019. CRC patients who are confirmed to be infection-free can receive routine treatment. Using online medical counseling and appropriate identification, treatment and follow-up was effectively maintained. |
|
Yermanos, Alexander, Agrafiotis, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
Here, we present Platypus, an open-source software platform providing a user-friendly interface to investigate B cell
receptor (BCR) and T cell receptor (TCR) repertoires from single-cell sequencing experiments. To showcase the capabilities of Platypus, we use it to analyze and visualize single-cell immune repertoires and transcriptomes from B and T cells from convalescent
COVID-19 patients, revealing unique insight into the repertoire features and transcriptional profiles of clonally expanded lymphocytes. Platypus will expedite progress by increasing accessibility to the broader immunology community by facilitating the analysis
of single-cell immune repertoire and transcriptome sequencing. |
|
|
Impact of COVID-19 Pandemic on Emergency Calls and Trauma Emergency Calls
in Hangzhou |
Zhang, Guohu, Wang, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
This study aimed to investigate the impact of the coronavirus disease 2019 (COVID-19) pandemic on emergency calls and
trauma emergency calls in Hangzhou, Zhejiang, China. This was a single-center retrospective study. Data on emergency calls and trauma emergency calls in Hangzhou during the COVID-19 epidemic (January 23, 2020, to March 15, 2020) were collected from the Hangzhou
Emergency Center (HEC). The number of emergency calls from HEC decreased by 17.1%, ambulance assignments by 29.1%, rescue personnel first-aid calls by 22.4%, and trauma emergency calls by 40.8% in 2020 compared with those during the same period in 2019. The
numbers of emergency calls from HEC and trauma emergency calls significantly decreased during the COVID-19 epidemic in Hangzhou, highlighting serious social issues that required the attention of the medical community and the government. |
|
Zhang, Xu-dong, Jing, et al |
Research Square prepub |
Mental Health |
|
We used the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), and the compulsive behavior part of
the Yale-Brown Obsessive-Compulsive Scale (YBOCS), combined with demographic information, using online questionnaires to research, and the study was conducted between February 21 and 24, 2020. A total of 2270 valid questionnaires were collected, the respondents
of these questionnaires included 563 medical students and 1707 non-medical students. Of the 563 medical students, 20 (3.55%) students had anxiety symptoms, and 57 (10.12%) students had depressive symptoms. Results indicated that gender, age, contact history
of similar infectious disease, past medical history (PMH), compulsive behavior, regularity of daily life, and exercise during the epidemic outbreak are the key factors making college students anxious or depressed. |
|
|
Zhang, Y, Chen, et al |
Emerg Microbes Infect |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
The possibility of potential faecal-oral transmission was investigated in this study. We collected 258 faecal specimens
from nine provinces in China and detected the nucleic acid of SARS-CoV-2 using real-time RT-PCR. Vero cells were used to isolate the virus from SARS-CoV-2 nucleic acid positive samples, after which sequencing of Spike gene in eight samples was performed. In
all, 93 of 258 (36%) stool samples were positive for SARS-CoV-2 RNA. The positive rates of critical, severe, moderate, and mild patients were 54.4%, 56.1%, 30.8%, and 33.3%, respectively. The live virus in faeces could be an important source of contamination,
which may lead to infection and further spread in areas with poor sanitary conditions. |
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The Impact of Social Distancing and Masking on COVID-19 Spread and Consumer Spending |
Zhao, Nan, Thomadsen, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
We examine the impact of Social Distancing and Masking on the spread of COVID-19 and on consumer spending. We first
estimate models of COVID-19 spread and consumer spending. We find that social distancing has a large effect on reducing COVID-19 spread, while the evidence on mask mandates is mixed. We also find that social distancing reduces consumer spending, but that mask
mandates increase consumer spending. Mask mandates also reduce social distancing, magnifying the positive effect on spending. Finally, we observe that social distancing varies significantly by political affiliation, with counties that had high vote shares
for Trump in 2016 engaging in significantly less social distancing than counties that had low vote shares for Trump in 2016. We demonstrate that if the whole country had engaged in Trump-supporting levels of social distancing instead of non-Trump-supporting
levels of social distancing, COVID-19 cases and deaths would be much higher, while consumer spending would only increase modestly. |
|
Zhao, Suli, Cao, et al |
Research Square prepub |
Mental Health |
|
This study compared the anxiety level of the frontline dental staff (FDS) to the general public in Yichang during the
coronavirus disease of 2019 (COVID-19) pandemic and examined potential explanatory factors to the differences. Two online questionnaires were used separately to collect data from FDS and the general public. The Chinese version of Becker Anxiety Inventory (BAI)
was included for the assessment of anxiety. In general, FDS were 4.342 (95% CI: 2.427-7.768) times more likely to suffer from anxiety disorder than the general public. The bivariate analysis showed that age, Level Three Protective Measures (PM-3), conflicts
with patients and/or colleagues were moderately associated with the anxiety state of FDS. During the COVID-19 pandemic, FDS were more likely to suffer from anxiety disorders than the general public. |
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Concerns About Information Regarding COVID-19 on the Internet: Cross-Sectional Study |
Zhao, Y, Xu, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
Our objectives were to determine Chinese netizens' concerns related to COVID-19 and the relationship between their
concerns and information on the internet. We also aimed to elucidate the association between individuals' levels of concern, knowledge, and behaviors related to COVID-19. The questionnaire, which consisted of 15 closed-ended questions, was designed to investigate
Chinese netizens' knowledge about COVID-19. In total, 10,304 respondents were surveyed on the internet (response rate=1.75%; 10,304/590,000). Nearly all (n=9803, 95.30%) participants were concerned about "confirmed cases" of COVID-19, and 87.70% (n=9036) received
information about the outbreak through social media websites. There were significant differences in participants' concerns by sex (P=.02), age (P<.001), educational attainment (P=.001), and occupation (P<.001). This study elucidated Chinese netizens' concerns,
information sources, and preventive behaviors related to the COVID-19 pandemic. Sex, educational attainment, occupation and employment status, knowledge acquisition, and level of concern were key factors associated with proper preventive behaviors. |
|
Zhao, Yuhang, Ji, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission |
We propose a new model to predict the course of the epidemic and simulate the transmission of the asymptomatic. The
model considers seven stages of infection: susceptible (S), exposed (E), infected (I), asymptomatic (A), confirmed (C), recovered (R), dead (D), we named it as SEIACRD. We used a model to study the interaction between asymptomatic patients and viral transmission.
Our model confirms that about 12 million people will be infected with the virus. Changes in mortality rates will be volatile, first falling, then rising. Not only the number of patients, but also the spread of the epidemic will be affected by the ability to
detect asymptomatic persons. American Asymptomatic patients have a strong interaction with epidemic transmission. |
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COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice |
Zheng, J, Wong, et al |
Nature |
Therapeutics| Thérapeutique Animal model | Modèle animal |
Although COVID-19 severity ranges from asymptomatic to lethal, most experimental infections provide insights into mild
disease. Here, using K18-hACE2 mice that we originally developed for SARS studies, we show that infection with SARS-CoV-2 causes severe disease in the lung, and in some mice, the brain. Evidence of thrombosis and vasculitis was detected in mice with severe
pneumonia. Furthermore, we show that infusion of convalescent plasma from a recovered patient with COVID-19 protected against lethal disease. Mice developed anosmia at early times after infection. Notably, although pre-treatment with convalescent plasma prevented
notable clinical disease, it did not prevent anosmia. Thus, K18-hACE2 mice provide a useful model for studying the pathological underpinnings of both mild and lethal COVID-19 and for assessing therapeutic interventions. |
|
Zhou, Y, Ji, et al |
Build Environ |
Transmission Healthcare Response | Réponse des soins de santé |
This study aims to investigate the transport of droplet aerosols generated by both doctors and patients to seek measures
to reduce the risk of infection. Taking a typical fever clinic as an object of study, two links in the actual diagnosis and treatment process are selected in this manuscript for investigation by experimental and numerical methods. The effects of different
cases of coughing and talking, as well as different contact distances, on the inhalation rate of human droplet aerosols are studied. The purification capacity of the ventilation is evaluated by the analysis results of the particle diffusion track and regional
concentration of the entire indoor area and breathing zones. The results show that purification of the same number of droplet aerosols and purification by ventilation work better for coughing than for talking. The best ventilation performance appeared for
the case of a patient sitting and coughing (PSC), while the case of a patient lying and talking (PLT) was the worst. Corresponding measures are suggested to improve the air purification effect and reduce the risk of cross infection. |
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Ali, MG, Zhang, et al |
Immunol Res |
Review Literature| Revue de littérature |
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Alpert, O, Begun, et al |
Brain Behav Immun Health |
Review Literature| Revue de littérature |
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Review of Cardiac Involvement in Multisystem Inflammatory Syndrome in Children |
Alsaied, T, Tremoulet, et al |
Circulation |
Review Literature| Revue de littérature |
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AlSubaie, AM |
Saudi J Biol Sci |
Review Literature| Revue de littérature |
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Andina, D, Belloni-Fortina, et al |
Clin Exp Dermatol |
Review Literature| Revue de littérature |
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A bibliometric analysis of covid-19 across science and social science research landscape |
Aristovnik, A, Ravšelj, et al |
Sustainability (Switzerland) |
Review Literature| Revue de littérature |
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Bhalla, M, Jolly, et al |
Semin Ophthalmol |
Review Literature| Revue de littérature |
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PMC7642729; Deep Learning and Medical Image Processing for Coronavirus (COVID-19) Pandemic: A Survey |
Bhattacharya, S, Reddy Maddikunta, et al |
Sustain Cities Soc |
Review Literature| Revue de littérature |
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Borrmann, H, McKeating, et al |
J Biol Rhythms |
Review Literature| Revue de littérature |
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Advancements in protein nanoparticle vaccine platforms to combat infectious disease |
Butkovich, N, Li, et al |
Wiley Interdiscip Rev Nanomed Nanobiotechnol |
Review Literature| Revue de littérature |
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Cluzel, N, Lambert, et al |
Comptes rendus biologies |
Review Literature| Revue de littérature |
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Collora, JA, Liu, et al |
Curr Opin HIV AIDS |
Review Literature| Revue de littérature |
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PMC7604014; Strategies to exiting the COVID-19 lockdown for workplace and school: A scoping review |
D'Angelo, D, Sinopoli, et al |
Saf Sci |
Review Literature| Revue de littérature |
ScR |
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COVID-19: Is there a role for immunonutrition in obese patient? |
Di Renzo, L, Gualtieri, et al |
J Transl Med |
Review Literature| Revue de littérature |
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Breastfeeding during the novel coronavirus (COVID-19) pandemic: guidelines and challenges |
Dimopoulou, D, Triantafyllidou, et al |
J Matern Fetal Neonatal Med |
Review Literature| Revue de littérature |
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Easterlin, MC, Crimmins, et al |
J Dev Orig Health Dis |
Review Literature| Revue de littérature |
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Fredericks, S, Miranda, et al |
Brain Behav Immun Health |
Review Literature| Revue de littérature |
Rapid Review: |
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Gadhvi, KA, Coco, et al |
Cornea |
Review Literature| Revue de littérature |
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The
biology of coronaviruses, with special regards to SARS-CoV-2-and COVID-19 |
Gyula, B, Ádám, et al |
Magyar Allatorvosok Lapja |
Review Literature| Revue de littérature |
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Impact of Remote Consultations on Antibiotic Prescribing in Primary Health Care: Systematic Review |
Han, SM, Greenfield, et al |
J Med Internet Res |
Review Literature| Revue de littérature |
SR: Searches were conducted in MEDLINE, Embase, HMIC, PsycINFO, and CINAHL for literature published since the databases'
inception to February 2020. There is insufficient evidence to confidently conclude that remote consulting has a significant impact on antibiotic prescribing in primary care. However, studies indicating higher prescribing rates in remote consultations than
in face-to-face consultations are a concern. |
|
Hong, TS, Gonzalez, et al |
Pharmacy (Basel) |
Review Literature| Revue de littérature |
SR-MA: searched PubMed, Web of Science, and medRxiv databases. HCQ alone or in combination with other drugs did not
significantly decrease mortality in hospitalized patients with COVID-19 (odds ratio OR], 0.95; 95% CI, 0.72-1.26; p = 0.732; I(2) = 91.05). |
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Ibn-Mohammed, T, Mustapha, et al |
Resour Conserv Recycl |
Review Literature| Revue de littérature |
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The first 6 months of HIV-SARS-CoV-2 coinfection: outcomes for 6947 individuals |
Johnston, R |
Curr Opin HIV AIDS |
Review Literature| Revue de littérature |
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Khiali, S, Rezagholizadeh, et al |
Expert Opin Biol Ther |
Review Literature| Revue de littérature |
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The Impact of the COVID-19 Pandemic on Maternal and Perinatal Health: A Scoping Review |
Kotlar, Bethany, Gerson, et al |
Research Square prepub |
Review Literature| Revue de littérature |
ScR: Pregnant women and mothers were not found to be at higher risk for COVID-19 than the general population, however
they seem to face disproportionate adverse socio-economic consequences. High income and low- and middle-income countries alike faced significant struggles.
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Laghrib, F, Saqrane, et al |
Microchem J |
Review Literature| Revue de littérature |
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MM-COVID: A Multilingual and Multidimensional Data Repository for CombatingCOVID-19 Fake New |
Li, Yichuan, Jiang, et al |
arXiv |
Review Literature| Revue de littérature |
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Learning from COVID-19: a systems approach for public health governance |
Liu, Jieling, Wu, et al |
Research Square prepub |
Review Literature| Revue de littérature |
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Spatio-temporal small area surveillance of the Covid-19 pandemics |
Martinez-Beneito, Miguel, Mateu, et al |
arXiv |
Review Literature| Revue de littérature |
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PMC7642731; SARS-CoV-2 associated COVID-19 in Geriatric Population: A Brief Narrative Review |
Mohamad Al-Zahrani, J |
Saudi J Biol Sci |
Review Literature| Revue de littérature |
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Naidu Ms Pharm, Sag D, Clemens Dr, et al |
J Diet Suppl |
Review Literature| Revue de littérature |
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Nguyen, NNT, McCarthy, et al |
Diagnostics (Basel) |
Review Literature| Revue de littérature |
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Omersel, J, Karas Kuželički, et al |
J Clin Med |
Review Literature| Revue de littérature |
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Clinically suspected myocarditis in the course of SARS-CoV-2 infection: fact or fiction? |
Ozieranski, K, Tyminska, et al |
J Card Fail |
Review Literature| Revue de littérature |
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An overview on COVID-19 pandemic: from discovery to treatment |
Panati, K, Tatireddygari, et al |
Infect Disord Drug Targets |
Review Literature| Revue de littérature |
|
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Evidence-based point-of-care technology development during the COVID-19 pandemic |
Parupudi, T, Panchagnula, et al |
BioTechniques |
Review Literature| Revue de littérature |
|
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PMC7534662; [Infection with SARS-CoV-2 in pregnancy. Update of Information and proposed care. CNGOF] |
Peyronnet, V, Sibiude, et al |
Gynecol Obstet Fertil Senol |
Review Literature| Revue de littérature |
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Pozi, MSM, Jatowt, et al |
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Review Literature| Revue de littérature |
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Rai, M, Bonde, et al |
Expert Rev Anti Infect Ther |
Review Literature| Revue de littérature |
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The pandemic that widens inequalities: Covid-19 and the education system in Quebec/Canada |
Russo, K, Magnan, et al |
Praxis Educativa |
Review Literature| Revue de littérature |
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Salehinejad, S, Niakan Kalhori, et al |
Inform Health Soc Care |
Review Literature| Revue de littérature |
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Schroeder, RA |
J Am Psychiatr Nurses Assoc |
Review Literature| Revue de littérature |
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Semino, E |
Health Commun |
Review Literature| Revue de littérature |
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SARS-CoV-2 Infection in Cancer Patients: Effects on Disease Outcomes and Patient Prognosis |
Seth, G, Sethi, et al |
Cancers (Basel) |
Review Literature| Revue de littérature |
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A Review on COVID-19 Mediated Impacts and Risk Mitigation Strategies for Dental Health Professionals |
Sharma, S, Parolia, et al |
Eur J Dent |
Review Literature| Revue de littérature |
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Suk, JonathanE, Vardavas, et al |
medRxiv |
Review Literature| Revue de littérature |
SR: The literature appraised provides sufficient evidence that children can both be infected by and transmit SARS-CoV-2
in community, household and school settings. Transmission by children was most frequently documented in household settings, while examples of children as index cases in school settings were rare. Included studies suggested that school closures may help to
reduce SARS-CoV-2 transmission, but the societal, economic, and educational impacts of prolonged school closures must be considered.
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Thijssen, M, Devos, et al |
Microorganisms |
Review Literature| Revue de littérature |
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Tleyjeh, IM, Kashour, et al |
Clin Microbiol Infect |
Review Literature| Revue de littérature |
SR-MA: vid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily, Ovid Embase, Ovid
Cochrane Central Register of Controlled Trials, Ovid Cochrane Database of Systematic Reviews, Web of Science, Scopus up, preprint servers and Google up to October 8, 2020. Cumulative moderate certainty evidence shows that tocilizumab reduces the risk of mechanical
ventilation in hospitalized COVID-19 patients. While RCTs showed that tocilizumab did not reduce short-term mortality, low certainty evidence from cohort studies suggests an association between tocilizumab and lower mortality. We did not observe a higher risk
of infections or adverse events with tocilizumab use. This review will continuously evaluate the role of tocilizumab in COVID-19 treatment. |
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Trachuk, P, Bartash, et al |
Lung |
Review Literature| Revue de littérature |
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COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics |
Tworowski, D, Gorohovski, et al |
Nucleic Acids Res |
Review Literature| Revue de littérature |
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Antioxidants/antihypoxants: The missing puzzle piece in effective pathogenetic therapy for
COVID-19 |
Voronina, TA |
Infektsionnye Bolezni |
Review Literature| Revue de littérature |
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Wang, Kun, Wu, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
SR: We searched PubMed, Cochrane Library, Embase and a Chinese database with the search terms “COVID-19” or “SARS-CoV-2”
and “Surgery” or “Operation” for all published articles on COVID-19 since the outbreak. The search was finalized on May 29th, 2020. COVID-19 patients, in particular whose with severe respiratory complications, may have high postoperative mortality. And, medical
staff in close contact with infected patients are suggested to take high level PPE.
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Wang, M, Wang, et al |
Curr Opin Allergy Clin Immunol |
Review Literature| Revue de littérature |
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ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities |
Zamorano Cuervo, N, Grandvaux, et al |
Elife |
Review Literature| Revue de littérature |
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Acuff, SF, Tucker, et al |
Exp Clin Psychopharmacol |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7543432; Upholding democracy in a global pandemic: the Israeli elections experience |
Afek, A, Leshem, et al |
J Travel Med |
Commentary/Editorial| Commentaire/Éditorial |
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Building trust in journals and in peer review: need of the hour during the COVID-19 pandemic |
Ahmed, S, Mohini |
Rheumatol Int |
Commentary/Editorial| Commentaire/Éditorial |
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Akbas, F, Usta Atmaca, et al |
Obes Facts |
Commentary/Editorial| Commentaire/Éditorial |
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Akimova, EI, Madzhuga, et al |
Perspektivy Nauki i Obrazovania |
Commentary/Editorial| Commentaire/Éditorial |
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Albert, CL, Carmona-Rubio, et al |
Circulation |
Commentary/Editorial| Commentaire/Éditorial |
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Ali, F, Sweeney, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Agricultural market operations across
the lockdown in J&K: An assessment |
Ali, J, Khan, et al |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Allocca, CM, Bledsoe, et al |
Biopreserv Biobank |
Commentary/Editorial| Commentaire/Éditorial |
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Althoff, KN, Coburn, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Anderson-Shaw, L, Zar, et al |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Falling Consumption and Demand for Electricity in South Africa - A Blessing and a Curse |
Andrade, JVB, Salles, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Az európai macskaegészségügyi tanácsadó
testület irányelvei a SARS-CoV-2 és a macskák kapcsolatáról |
Anna, S |
Magyar Allatorvosok Lapja |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19-associated coagulopathy and disseminated intravascular coagulation |
Asakura, H, Ogawa, et al |
Int J Hematol |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in Latin America: Symptoms, Morbidities and Gastrointestinal Manifestations |
Ashktorab, H, Pizuorno, et al |
Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 Pandemic: Theoretical and Practical Perspectives on Children, Women and Sex Trafficking |
Asongu, Simplice, Usman, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Nutritional strategies for the rehabilitation of COVID-19 patients |
Azzolino, D, Passarelli, et al |
Eur J Clin Nutr |
Commentary/Editorial| Commentaire/Éditorial |
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Mechanic Forces Promote Brain Endothelial Activation by SARS-CoV-2 Spike Protein |
Babendreyer, A, Ludwig, et al |
Stroke |
Commentary/Editorial| Commentaire/Éditorial |
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Bachmann, SD, Sanden, et al |
Indonesian Journal of International and Comparative Law |
Commentary/Editorial| Commentaire/Éditorial |
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Pooled testing for SARS-CoV-2 could provide the solution to UK's testing strategy |
Ball, J, McNally, et al |
BMJ |
Commentary/Editorial| Commentaire/Éditorial |
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Efficacy of clinical evaluations for COVID-19 on the front line |
Barsky, LL, Ebinger, et al |
Int J Emerg Med |
Commentary/Editorial| Commentaire/Éditorial |
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Can BCG vaccine protect against COVID-19 via trained immunity and tolerogenesis? |
Basak, P, Sachdeva, et al |
Bioessays |
Commentary/Editorial| Commentaire/Éditorial |
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Are the users of Valved N95 masks 'innocent spreaders' of COVID-19? |
Bawa, A, Wander, et al |
Journal of Anaesthesiology Clinical Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: Opportunities for interdisciplinary research to improve care for older people in Sweden |
Baxter, R, Jemberie, et al |
Scand J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Bekerman, Z |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Best, N, Mohring, et al |
Physikalische Medizin Rehabilitationsmedizin Kurortmedizin |
Commentary/Editorial| Commentaire/Éditorial |
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Justice, Well-Being, and Civic Duty in the Age of a Pandemic: Why we all Need to Do our bit |
Bester, JC |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Effect of inadvertent steroid use during COVID-19 lockdown in chronic illnesses in children |
Bhalla, K, Verma, et al |
Trop Doct |
Commentary/Editorial| Commentaire/Éditorial |
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Bhatia, N |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Ethical Challenges in Clinical Research During the COVID-19 Pandemic |
Bierer, BE, White, et al |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Social Estrangement and Psychological Distress before and during the COVID-19 Pandemic |
Bierman, A, Schieman, et al |
J Health Soc Behav |
Commentary/Editorial| Commentaire/Éditorial |
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Black Square, BS |
J Neurosurg Anesthesiol |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7337814; The long journey inside immigration detention centres in the USA |
Bonfiglio, G, Rosal, et al |
J Travel Med |
Commentary/Editorial| Commentaire/Éditorial |
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Responsibility of health professionals in screening for domestic violence during a COVID-19 pandemic |
Bradley, NL, DiPasquale, et al |
CMAJ |
Commentary/Editorial| Commentaire/Éditorial |
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Breitbart, W |
Palliat Support Care |
Commentary/Editorial| Commentaire/Éditorial |
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Response to: Nutritional strategies for the rehabilitation of COVID-19 patients |
Brugliera, L, Spina, et al |
Eur J Clin Nutr |
Commentary/Editorial| Commentaire/Éditorial |
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Bunch, A, Ardila, et al |
Blood Purif |
Commentary/Editorial| Commentaire/Éditorial |
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Buoite Stella, A, Filingeri, et al |
Int J Biometeorol |
Commentary/Editorial| Commentaire/Éditorial |
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Interview: Mourning Is a Political Act Amid the Pandemic and Its Disparities (Republication) |
Butler, J, Yancy, et al |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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What Pfizer's landmark COVID vaccine results mean for the pandemic |
Callaway, E |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Camporesi, S |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Cao, Y, Shan, et al |
PLoS One |
Commentary/Editorial| Commentaire/Éditorial |
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Carethers, JM |
J Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Carmichael, R, Wainwright, et al |
Clinical Psychology Forum |
Commentary/Editorial| Commentaire/Éditorial |
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Of masks and men? gender, sex and protective measures during covid-19 |
Cassino, D, Besen-Cassino, et al |
Politics and Gender |
Commentary/Editorial| Commentaire/Éditorial |
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Proinflammatory IgG Fc structures in patients with severe COVID-19 |
Chakraborty, S, Gonzalez, et al |
Nat Immunol |
Commentary/Editorial| Commentaire/Éditorial |
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Chen, Q, Allot, et al |
Nucleic Acids Res |
Commentary/Editorial| Commentaire/Éditorial |
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Chen, RT, Kochhar, et al |
Vaccine |
Commentary/Editorial| Commentaire/Éditorial |
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Synergistic Disparities and Public Health Mitigation of COVID-19 in the Rural United States |
Chillag, KL, Lee, et al |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Chow, B, Rallis, et al |
Am J Hosp Palliat Care |
Commentary/Editorial| Commentaire/Éditorial |
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Cohen, KB, Gifu, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Colabufo, NA, Leopoldo, et al |
ACS Medicinal Chemistry Letters |
Commentary/Editorial| Commentaire/Éditorial |
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Persons with HIV and the COVID-19 Pandemic: A Viral Synergy of Biology and Sociology |
Collins, LF |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Collins, LF, Colasanti, et al |
AIDS |
Commentary/Editorial| Commentaire/Éditorial |
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Social Justice for Public Health: The COVID-19 Response in Portugal |
Cordeiro-Rodrigues, L |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Costanzi, A, Mari, et al |
J Trauma Acute Care Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Covre, LP, De Maeyer, et al |
Aging Cell |
Commentary/Editorial| Commentaire/Éditorial |
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Dam, P, Mandal, et al |
J Transp Health |
Commentary/Editorial| Commentaire/Éditorial |
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Cardiovascular Imaging in COVID-19: Focus on safety, value, and clinical relevance |
Dani, SS, Bagga, et al |
Trends Cardiovasc Med |
Commentary/Editorial| Commentaire/Éditorial |
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Dario, A |
Neuromodulation |
Commentary/Editorial| Commentaire/Éditorial |
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Daviet, F, Guervilly, et al |
Circulation |
Commentary/Editorial| Commentaire/Éditorial |
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Dawson, C, Capewell, et al |
J Laryngol Otol |
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de Jouvenel, H |
Futuribles: Analyse et Prospective |
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de Lesquen, H, Bergez, et al |
Mil Med |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 in prisons: A study of habeas corpus decisions by the São Paulo court of justice |
de Vasconcelos, NP, Machado, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
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Convalescent plasma therapy in COVID 19: Every dark cloud has a silver lining |
Deokar, K, Chawla, et al |
Journal of Anaesthesiology Clinical Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Nanoconjugates-Based Stem Cell Therapy for the Management of COVID-19 |
Desai, D, Shende, et al |
Stem Cell Rev Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Healthcare Professional Standards in Pandemic Conditions: The Duty to Obtain Consent to Treatment |
Devaney, S, Miola, et al |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Devilliers, MJ, Ben Hadj Salah, et al |
Rev Med Interne |
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Diamond, B, Volpe, et al |
Mol Med |
Commentary/Editorial| Commentaire/Éditorial |
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Toward equitable participatory design: Data feminism for CSCW amidst multiple pandemics |
D'Ignazio, C, Graeff, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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ORGAN DONATION AND TRANSPLANTATION DURING THE COVID-19 PANDEMIC: A SUMMARY OF THE SPANISH EXPERIENCE |
Domínguez-Gil, B, Fernández-Ruiz, et al |
Transplantation |
Commentary/Editorial| Commentaire/Éditorial |
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A narratology of dystopia during COVID-19: A discourse in social media |
Dubi, YB |
NALANS: Journal of Narrative and Language Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Duggan, LV, Mastoras, et al |
CMAJ |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Denmark to kill 17 million minks over mutation that could undermine vaccine effort |
Dyer, O |
BMJ |
Commentary/Editorial| Commentaire/Éditorial |
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Eckenwiler, LA |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Ought Conscientious Refusals to Implement Reverse Triage Decisions be Accommodated? |
Emmerich, N |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Esteves, R, Sussman, et al |
Economists' Voice |
Commentary/Editorial| Commentaire/Éditorial |
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Quarantine lessons: Limits and possibilities of teaching performance in times of social isolation |
Ferreira, LH, Barbosa, et al |
Praxis Educativa |
Commentary/Editorial| Commentaire/Éditorial |
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Gandhi, Darshan, Landage, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Emergence of Telehealth for anesthesiologists in COVID-19 - Boon for all! |
Garg, R, Hoda, et al |
Journal of Anaesthesiology Clinical Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of COVID-19 Pandemic on the Role of Cardiac Sonographers |
Garg, VP, Isath, et al |
J Am Soc Echocardiogr |
Commentary/Editorial| Commentaire/Éditorial |
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Genomics in the era of COVID-19: ethical implications for clinical practice and public health |
Geller, G, Duggal, et al |
Genome Med |
Commentary/Editorial| Commentaire/Éditorial |
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Telling the Truth to Child Cancer Patients in COVID-19 Times |
Gillam, L, Spriggs, et al |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Gilliland, S, Latham, et al |
Semin Cardiothorac Vasc Anesth |
Commentary/Editorial| Commentaire/Éditorial |
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Gladka, MM, Maack, et al |
Cardiovasc Res |
Commentary/Editorial| Commentaire/Éditorial |
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Nonlinear approximations to critical and relaxation processes |
Gluzman, S |
Axioms |
Commentary/Editorial| Commentaire/Éditorial |
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African American Faith Communities and Public Health: Working at the Intersections of COVID-19 |
Goldblum, Peter, Thompkins, et al |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
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An online coronavirus analysis platform from the National Genomics Data Center |
Gong, Z, Zhu, et al |
Zool Res |
Commentary/Editorial| Commentaire/Éditorial |
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Goodman, LA, Epstein, et al |
J Fam Violence |
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Goodsmith, N, Ijadi-Maghsoodi, et al |
Psychiatr Serv |
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Gorfinkel, L, Muscat, et al |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
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Gray, B |
J Bioeth Inq |
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Covid-19: NHS England should manage test and trace system, says Independent SAGE |
Griffin, S |
BMJ |
Commentary/Editorial| Commentaire/Éditorial |
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Gu, HQ, Wang, et al |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Prone position in ARDS patients: why, when, how and for whom |
Guérin, C, Albert, et al |
Intensive Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Gurdasani, Deepti, Bear, et al |
The Lancet |
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Hadler, JL |
J Infect Dis |
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Hamidi, F, Babapour, et al |
Journal of Reproduction and Infertility |
Commentary/Editorial| Commentaire/Éditorial |
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Controlled Trials Needed to Prove Efficacy and Safety of Convalescent Plasma Therapy in COVID-19 |
Hartog, N, Holsworth, et al |
Ann Allergy Asthma Immunol |
Commentary/Editorial| Commentaire/Éditorial |
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Hellsten, L |
Approaching Religion |
Commentary/Editorial| Commentaire/Éditorial |
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Heralding the Digitalization of Life in Post-Pandemic East Asian Societies |
Ho, CW, Caals, et al |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Hooker, C, Leask, et al |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Early triple antiviral therapy for COVID-19 - Authors' reply |
Hung, IF, Yuen, et al |
Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Hussen, J, Kandeel, et al |
Pathogens |
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Covid-19: Hospitals forced to suspend routine care amid second surge |
Iacobucci, G |
BMJ |
Commentary/Editorial| Commentaire/Éditorial |
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Inno, L, Rotundi, et al |
Nature Astronomy |
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Inserro, A |
American Journal of Managed Care |
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Protocolized approach to a COVID-19 parturient undergoing a cesarean section - A case report |
Jain, K, Alen, et al |
Journal of Anaesthesiology Clinical Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Jordens, CFC |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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Effect and Reach of Medical Articles Posted on Preprint Servers During the COVID-19 Pandemic |
Jung, YEG, Sun, et al |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Kantrowitz-Gordon, I |
J Midwifery Womens Health |
Commentary/Editorial| Commentaire/Éditorial |
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Even in a Pandemic, Sunlight is the Best Disinfectant: COVID-19 and Global Freedom of Expression |
Karanicolas, Michael |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Katayama, H |
Bioessays |
Commentary/Editorial| Commentaire/Éditorial |
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Correction to: Comparing Associations of State Reopening Strategies with COVID-19 Burden |
Kaufman, BG, Whitaker, et al |
J Gen Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: through the eyes through the front line, an international perspective |
Kavanagh, KT, Pare, et al |
Antimicrob Resist Infect Control |
Commentary/Editorial| Commentaire/Éditorial |
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Monitor for COVID-19 vaccine resistance evolution during clinical trials |
Kennedy, DA, Read, et al |
PLoS Biol |
Commentary/Editorial| Commentaire/Éditorial |
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Identification of risk factors for mortality in COVID-19 patients |
Kim, EY |
Acute Crit Care |
Commentary/Editorial| Commentaire/Éditorial |
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So far, how effective were distancing measures during the COVID-19 pandemic? |
Klein, F |
Deutsche medizinische Wochenschrift |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7577681; Public support for development aid during the COVID-19 pandemic |
Kobayashi, Y, Heinrich, et al |
World Dev |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 pandemic: The value of antibody testing for imaging facilities |
Kohli, A |
Indian Journal of Radiology and Imaging |
Commentary/Editorial| Commentaire/Éditorial |
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Kratochvil, D, Hill, et al |
Australas Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Smell impairment in COVID-19 patients: Mechanisms and clinical significance |
Kryukov, AI, Kazakova, et al |
Vestnik otorinolaringologii |
Commentary/Editorial| Commentaire/Éditorial |
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An Analysis of K-12 School Reopening and Its’ Impact on Teachers |
Lambert, JA, Trott, et al |
Journal of Primary Care and Community Health |
Commentary/Editorial| Commentaire/Éditorial |
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Major rise of a chronic lymphoid leukemia clone during the course of COVID-19 |
Largeaud, L, Ribes, et al |
Int J Lab Hematol |
Commentary/Editorial| Commentaire/Éditorial |
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Lazarus, HM, Gale, et al |
Acta Haematol |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7566764; Post-pandemic transformations: How and why COVID-19 requires us to rethink development |
Leach, M, MacGregor, et al |
World Dev |
Commentary/Editorial| Commentaire/Éditorial |
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Lee, SG, Fralick, et al |
CMAJ |
Commentary/Editorial| Commentaire/Éditorial |
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Toward standardization in biotechnology platforms to support smart manufacturing |
Lin-Gibson, S, Srinivasan, et al |
Smart and Sustainable Manufacturing Systems |
Commentary/Editorial| Commentaire/Éditorial |
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Lipworth, W |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
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|
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Liu, X, Tang, et al |
J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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|
|
Luigetti, M, Frisullo, et al |
J Clin Med |
Commentary/Editorial| Commentaire/Éditorial |
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Lusk, P |
J Child Adolesc Psychiatr Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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Ultraprocessed Food: Addictive, Toxic, and Ready for Regulation |
Lustig, RH |
Nutrients |
Commentary/Editorial| Commentaire/Éditorial |
|
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PMC7643524; From the Front Lines of COVID-19 at HSS: An Oral History |
MacKenzie, CR, Jacobson, et al |
HSS J |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Vaccine candidate may be more than 90% effective, interim results indicate |
Mahase, E |
BMJ |
Commentary/Editorial| Commentaire/Éditorial |
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Interpretation of laboratory tests for prevention of the SARS-CoV-2 transmission |
Masui, K |
J Anesth |
Commentary/Editorial| Commentaire/Éditorial |
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Mazzuoli, VO |
Indonesian Journal of International and Comparative Law |
Commentary/Editorial| Commentaire/Éditorial |
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McKeeby, JW, Siwy, et al |
J Am Med Inform Assoc |
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McPartlin, SO, Morrison, et al |
BMJ |
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McWilliams, JM, Mehrotra, et al |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Standards of Care in Crisis: ST-Segment-Elevation Myocardial Infarction Management in
COVID-19 |
Mihatov, N, Kirtane, et al |
Circ Cardiovasc Interv |
Commentary/Editorial| Commentaire/Éditorial |
|
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Educational transformations in pandemic times: From social confinement to curriculum isolation |
Morgado, JC, Sousa, et al |
Praxis Educativa |
Commentary/Editorial| Commentaire/Éditorial |
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Adolescenti in tempo di Covid-19: Dalla movida alla responsabilità |
Musso, P, Cassibba, et al |
Psicologia Clinica dello Sviluppo |
Commentary/Editorial| Commentaire/Éditorial |
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|
Naidu, SAG, Clemens, et al |
J Diet Suppl |
Commentary/Editorial| Commentaire/Éditorial |
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Afterthoughts from an Unexpected Morbidity under COVID-19 pandemic |
Navarro, F, Jarry, et al |
J Invest Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Nudi, R, Campagna, et al |
Panminerva Med |
Commentary/Editorial| Commentaire/Éditorial |
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Harm reduction in the time of COVID-19: Case study of homelessness and drug use in Dublin, Ireland |
O'Carroll, A, Duffin, et al |
Int J Drug Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Omland, T, Prebensen, et al |
Circulation |
Commentary/Editorial| Commentaire/Éditorial |
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Preserving Bodily Integrity of Deceased Patients From the Novel SARS-CoV-2 Pandemic in West Africa |
Omonzejele, PF |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
|
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What Triage Issues Reveal: Ethics in the COVID-19 Pandemic in Italy and France |
Orfali, K |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Orisaka, M, Kawamura, et al |
J Obstet Gynaecol Res |
Commentary/Editorial| Commentaire/Éditorial |
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Ortega, P, Shin, et al |
Acad Med |
Commentary/Editorial| Commentaire/Éditorial |
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Plantation Politics, Paranoia, and Public Health on the Frontlines of America's COVID-19 Response |
Oyarzun, Y |
Med Anthropol Q |
Commentary/Editorial| Commentaire/Éditorial |
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Open Burn Pit Exposure and Concern About the COVID-19 Pandemic |
Padala, KP, Padala, et al |
Prim Care Companion CNS Disord |
Commentary/Editorial| Commentaire/Éditorial |
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|
Parichehreh-Dizaji, S, Haghpanah, et al |
Biopreserv Biobank |
Commentary/Editorial| Commentaire/Éditorial |
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The emergence of english as a lingua digital within chaos/Complexity theory framework |
Peker, H, Akkaya, et al |
NALANS: Journal of Narrative and Language Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Péter, OM |
Orv Hetil |
Commentary/Editorial| Commentaire/Éditorial |
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Unproctored Online Summative Assessments During the COVID-19 Pandemic: A Plea for Transparency |
Prakash, ES, Kacsoh, et al |
Acad Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pratt, D |
Dancing Times |
Commentary/Editorial| Commentaire/Éditorial |
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Rashidpouraie, R, Sharifi, et al |
Obstet Gynecol Sci |
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Special Section Involvement of lipids in the occurrence of COVID-19 |
Rioux, V, Record, et al |
Biochimie |
Commentary/Editorial| Commentaire/Éditorial |
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Misguided Use of Hydroxychloroquine for COVID-19: The Infusion of Politics Into Science |
Saag, MS |
JAMA |
Commentary/Editorial| Commentaire/Éditorial |
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Sadeghi, MR |
Journal of Reproduction and Infertility |
Commentary/Editorial| Commentaire/Éditorial |
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A Critique of New Zealand’s Exclusive Approach to Intercultural Education |
Salahshour, N |
New Zealand Journal of Educational Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Savulescu, J |
J Med Ethics |
Commentary/Editorial| Commentaire/Éditorial |
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Herausforderungen: Für den
lehr- und forschungsbetrieb im aaaschinebäu aufgrund von sars-COV-2 |
Schmitz, K |
O+P Fluidtechnik |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Schuster-Bruce, A, Middleton, et al |
Breast J |
Commentary/Editorial| Commentaire/Éditorial |
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|
Using Persuasion Science to Improve COVID-19 Contact Tracing |
Sciamanna, C, Du, et al |
Am J Infect Control |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Risk of Severe COVID-19 Among Workers and Their Household Members |
Selden, TM, Berdahl, et al |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Semi, G |
Polis (Italy) |
Commentary/Editorial| Commentaire/Éditorial |
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|
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Sharma, B |
J Med Virol |
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Shaw, PD, Rao, et al |
Infect Dis (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
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What Matters? Palliative Care, Ethics, and the COVID-19 Pandemic |
Sheahan, L, Brennan, et al |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Shun-Ching Chan, C, Joosse, et al |
Etnografia e Ricerca Qualitativa |
Commentary/Editorial| Commentaire/Éditorial |
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|
|
Signer, J, Jonsdottir, et al |
Virol J |
Commentary/Editorial| Commentaire/Éditorial |
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US election: Biden announces covid-19 task force, promising "compassion, empathy, and concern" |
Silberner, J |
BMJ |
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|
|
Singh, R |
Industrial Biotechnology |
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|
|
Psychiatric disorders and risk of infections: early lessons from COVID-19 |
Smith, MeghanL, Gradus, et al |
The Lancet Healthy Longevity |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ethnography and the new normal. Observational studies, analytic orientations, and practical ethics |
Smith, RJ, Ablitt, et al |
Etnografia e Ricerca Qualitativa |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Left Reflects on the Global Pandemic and Speaks to Transform! |
Spivak, GC |
J Bioeth Inq |
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Tele-Preanesthetic check-ups (TelePAC) during COVID-19: Apprehensions and possibilities |
Srivastava, D, Solanki, et al |
Journal of Anaesthesiology Clinical Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mental Capacity Assessments for COVID-19 Patients: Emergency Admissions and the CARD Approach |
Stewart, C, Biegler, et al |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 and Australian Prisons: Human Rights, Risks, and Responses |
Stewart, C, Tomossy, et al |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
|
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ILCOR's revised Covid-19 defibrillation recommendation requires a new approach to training |
Stewart, JA |
Scand J Trauma Resusc Emerg Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Facing the Ethical Challenges: Consumer Involvement in COVID-19 Pandemic Research |
Straiton, N, McKenzie, et al |
J Bioeth Inq |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Takagi, H |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Lancet Healthy, Longevity |
The Lancet Healthy Longevity |
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|
|
|
Theoharides, TC |
Ann Allergy Asthma Immunol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Thomé, BC, Matta, et al |
J Bioeth Inq |
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|
|
|
The criteria used to justify endotracheal intubation of patients with COVID-19 are worrisome |
Tobin, MJ |
Can J Anaesth |
Commentary/Editorial| Commentaire/Éditorial |
|
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Scientists relieved as Joe Biden wins tight US presidential election |
Tollefson, J |
Nature |
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|
|
Surgery in crisis in the era of COVID-19: transformational changes in sight |
Urbach, DR, Martin, et al |
CMAJ |
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|
|
Vergara, J, Lirani-Silva, et al |
Otolaryngol Head Neck Surg |
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|
|
|
Sports participation of patients with haemophilia in the COVID-19 era: The Dutch experience |
Versloot, O, van der Net, et al |
Haemophilia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Voysey, M, Pollard, et al |
Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Wade, DT |
Clin Rehabil |
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|
|
|
Wadoo, O, Latoo, et al |
General Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A juggling act – being a
parent/prospective parent and a clinician during covid-19 |
Weiner, B, Phillips, et al |
Clinical Psychology Forum |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7543444; BCG as an adjunct or alternative vaccine to prevent COVID-19? |
Weng, CH, Chan, et al |
J Travel Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wiltshire, J |
J Bioeth Inq |
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|
|
|
Wong, DJN, Ahmad, et al |
Can J Anaesth |
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|
|
|
Wright, LS, Louisias, et al |
J Allergy Clin Immunol |
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|
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Xiong, R, Zhang, et al |
Protein Cell |
Commentary/Editorial| Commentaire/Éditorial |
|
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Yasri, S, Wiwanitkit, et al |
Endoscopy |
Commentary/Editorial| Commentaire/Éditorial |
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|
Yepes-Temiño, MJ, Callejas González, et al |
Rev Esp Anestesiol Reanim |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The outcome of COVID-19 in patients with hematological malignancy |
Yigenoglu, TN, Bascı, et al |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 and psychiatry: can electronic medical records provide the answers? |
Yolken, Robert |
The Lancet Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Working with bipolar disorder during the covid-19 pandemic: Both crisis and opportunity |
Youngstrom, EA, Hinshaw, et al |
WikiJournal of Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zanon, D, Musazzi, et al |
Data Brief |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zhou, Y |
Etnografia e Ricerca Qualitativa |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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COVID-19 and Vaccination of Children and Adolescents: Prospects and Challenges |
Zimet, GD, Silverman, et al |
J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zordan, P, Almeida, et al |
Praxis Educativa |
Commentary/Editorial| Commentaire/Éditorial |
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Psychol Sci |
Commentary/Editorial| Commentaire/Éditorial |
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Correction: Patient Trajectories Among Persons Hospitalized for COVID-19 |
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Ann Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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COVID research updates: Uninfected children have antibodies to the coronavirus |
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Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Futuribles: Analyse et Prospective |
Commentary/Editorial| Commentaire/Éditorial |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.*
Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.
Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers.
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Séquelles à long terme:
Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.
Santé mentale:
Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées
à la pandémie.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives