Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19,
2020-11-10
Good afternoon,
There are 1016 citations in today’s scan. 508 were considered primary research or review literature.
Highlights today include:
CANADA / NORTH AMERICA
·
Taylor et al studied the prevalence of vaccination hesitancy for a SARS-CoV2 vaccine, the motivational roots of this hesitancy, and the most promising incentives for improving
the likelihood of vaccination uptake when a vaccine does become available. Many American (25%) and Canadian (20%) respondents said that they would not get vaccinated against SARS-CoV2 if a vaccine was available. Vaccine rejection was most strongly correlated
with mistrust of vaccine benefit, and also correlated with worry about unforeseen future effects, concerns about commercial profiteering from pharmaceutical companies, and preferences for natural immunity. When asked about incentives for getting vaccinated,
respondents were most likely to report that evidence for rigorous testing and safety of the vaccine were of greatest importance.
PUBLIC HEALTH INTERVENTION
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Khosronejad et al
conducted fluid dynamics simulations to elucidate the underlying physics of saliva particulate transport during human cough with and without facial masks. Results show that during indoor coughing some saliva particulate/s could travel up to 0.48 m, 0.73
m, and 2.62 m for the cases with medical-grade, non-medical grade, and without facial masks, respectively. In indoor environments either medical or non-medical grade facial masks can successfully limit the spreading of saliva particulates to others. Under
outdoor conditions with a unidirectional mild breeze, however, leakage flow through the mask can cause saliva particulates to be entrained into the energetic shear layers around the body and transported very fast at large distances by the turbulent flow, thus,
limiting the effectiveness of facial masks.
TRANSMISSION
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Politis et al.
studied haemovigilance findings from a three-month surveillance period during the pandemic. They determined one incidence of an immunosuppressed patient who had been transfused with whole blood derived platelets from a donor subsequently diagnosed with
COVID-19. The recipient exhibited no disease symptoms and was negative on both molecular and antibody testing, suggesting that SARS-CoV-2 transmission through transfusion is low risk.
EPIDEMIOLOGY
·
Glaeser et al
use zip code data across five U.S. cities, to estimate that total cases per capita decrease by 19% for every ten percentage point fall in mobility. We find substantial spatial and temporal heterogeneity; east coast cities have stronger effects, with
the largest for NYC in the pandemic’s early stages.
CLINICAL DATA
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Wormser et al. found that prone position in wards improved alveolar exchange during posture and is well-tolerated. This technique could be used in any medical
ward.
IMMUNOLOGY
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Bastard et al
report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG autoantibodies (auto-Abs) against interferon-ω, against the 13 types of IFN-α, or against both at the onset of critical disease. The auto-Abs neutralize
the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs
were aged 25 to 87.
·
Sherina et al
examined the serum anti-SARS-CoV-2 antibody levels and virus specific memory B- and T-cell responses over time in convalescent COVID-19 patients. Anti-SARS-CoV-2 antibodies were present in 85% samples collected within 4 weeks after onset of symptoms
in COVID-19 patients. Although the serum levels of anti-SARS-CoV-2 IgG antibodies started to decline, virus-specific T and/or memory B cell responses increased with time and maintained during the study
·
Reche P.A. Authors explored the potential role of cross-reactive
immunity acquired from pediatric vaccinations and exposure to common human pathogens in the protection and pathology of COVID-19. Children may well be protected from SARS-CoV-2 through cross-reactive immunity elicited by DTP vaccinations, supporting testing
in the general population to prevent COVID-19.
DIAGNOSTICS
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Heggestad et al assessed the levels of anti-SARS-CoV-2 antibodies in plasma samples from 19 individuals (at multiple time points) with COVID-19 that required
admission to the intensive care unit and from 10 healthy individuals. This POC assay shows good concordance with a live virus microneutralization assay, achieved high sensitivity (100%) and specificity (100%), and successfully tracked the longitudinal evolution
of the antibody response in infected individuals. Test requires minimal user intervention and is read by a handheld detector, it can be globally deployed in the fight against COVID-19.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley
Otten, Irene Yong, Drew Greydanus, Shalane Ha, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark, Catherine Card
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics /
Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance,
Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, Immunologie,
économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
A rare axonal variant of guillain-barré syndrome as a neurological complication of covid-19 infection |
Abbaslou, MA, Karbasi, et al |
Archives of Iranian Medicine |
Clinical data| Données cliniques |
This report presents a case of a 55-years -old female who was hospitalized with dyspnea, dry cough, and myalgia and
PCR +ve for COVID-19. She developed Acute Motor & Sensory Axonal Neuropathy (AMSAN), a rare variant of GBS signs and symptoms including decreased muscle strength and pinprick sensation in both lower extremities during her hospitalization. |
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An intelligent framework using disruptive technologies for COVID-19 analysis |
Abdel-Basset, M, Chang, et al |
Technological Forecasting and Social Change |
Modelling/ prediction| Modélisation/prédiction Clinical data| Données cliniques Public health interventions*| Interventions
de santé publique |
This paper describes a framework using disruptive technologies for COVID-19 analysis. Disruptive technologies include high-tech and emerging technologies
such as AI, industry 4.0, IoT, Internet of Medical Things (IoMT), big data, virtual reality (VR), Drone technology, and Autonomous Robots, 5 G, and blockchain to offer digital transformation, research and development and service delivery. The proposed framework
restricts the spread of COVID-19 outbreaks, ensures the safety of the healthcare teams and maintains patients' physical and psychological healthcare conditions. The framework is designed to deal with the severe shortage of PPE for the medical team, reduce
the massive pressure on hospitals, and track recovered patients to treat COVID-19 patients with plasma. The study provides oversight for governments on how to adopt technologies to reduce the impact of unprecedented outbreaks for COVID-19. Our work illustrates
an empirical case study on the analysis of real COVID-19 patients and shows the importance of the proposed intelligent framework to limit the current outbreaks for COVID-19. The aim is to help the healthcare team make rapid decisions to treat COVID-19 patients
in hospitals, home quarantine, or identifying and treating patients with typical cold or flu. |
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Abdulaal, Ahmed, Patel, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Clinical data| Données cliniques |
The aim of the study was to develop and compare two separate predictive models for death during admission with SARS-CoV-2. Between March 1 - April 24,
2020, 398 patients were identified with laboratory confirmed SARS-CoV-2 in a London teaching hospital. Data from electronic health records were extracted and used to create two predictive models using: 1) a Cox regression model and 2) an artificial neural
network (ANN). Model performance profiles were assessed by validation, discrimination, and calibration. Both the Cox regression and ANN models achieved high accuracy (83.8%, 95% confidence interval (CI): 73.8 - 91.1 and 90.0%, 95%CI: 81.2 - 95.6, respectively).
The area under the receiver operator curve (AUROC) for the ANN (92.6%, 95% CI: 91.1 - 94.1) was significantly greater than that of the Cox regression model (86.9%, 95% CI: 85.7 - 88.2), p=0.0136. Both models achieved acceptable calibration with Brier scores
of 0.13 and 0.11 for the Cox model and ANN, respectively. Conclusion We demonstrate an ANN which is non-inferior to a Cox regression model but with potential for further development such that it can learn as new data becomes available. |
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COVID-19 information-related digital literacy among online health consumers
in a low-income country |
Abdulai, AF, Tiffere, et al |
International journal of medical informatics |
Public Health response| Interventions de santé publique |
The study revealed a high overall digital literacy as well as sex and age differences in literacy levels among online health consumers in Ghana. However,
respondents’ ability to locate COVID-19 related informaion and their skills in differentiating scientific from unscientific internet-based information remain relatively low. These findings offer useful insight that can inform the design of inclusive internet-based
preventive resources that would be accessible and understandable to laypeople across all age groups and sexes in low-income countries. |
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Adawee, MO, Brum, et al |
J Occup Environ Med |
Clinical data| Données cliniques Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) Healthcare
Response | Réponse des soins de santé |
The aim of this quality improvement project was to survey commonalities among healthcare personnel who tested positive for COVID-19 and to evaluate the
effectiveness the organizational intervention to require healthcare personnel wear masks throughout their shift. Information regarding the 40 healthcare personnel who tested positive for COVID-19 between the dates of March 18, 2020 and May 13, 2020 were included.
The most common types of symptoms reported were cough, headache, and fever. Fourteen days after the requirement for healthcare personnel across the organization to wear masks throughout their shift was implemented, a 67% reduction in positive tests among healthcare
personnel involved in a workplace exposure was observed. |
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Afat, S, Othman, et al |
Diagnostics |
Clinical data| Données cliniques |
To evaluate contrast-enhanced dual-energy computed tomography (DECT) chest examinations regarding pulmonary perfusion
patterns and pulmonary opacities in patients with confirmed COVID-19 disease. Fourteen patients with 24 DECT examinations performed between April and May 2020 were included in this retrospective study. The main pulmonary findings were ground glass opacities
(GGO) in all 24 examinations and pulmonary consolidations in 22 examinations. |
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Knowledge and attitudes of ajman university dentists towards the coronavirus (COVID-19) |
Afraa, S, Raghad, et al |
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Healthcare Response | Réponse des soins de santé |
This study evaluates Ajman university dental professionals' knowledge and attitudes towards corona virus and the applied
strategies for its prevention and treatment. The questionnaire consists of three parts (demographic, knowledge, and attitudes) towards corona virus which was filled by 297 dentists. The study findings revealed that dental professionals showed good knowledge
towards virus transmission, however there are missing information of other ways of transmission. This finding indicates that providing information strategies by health institutions should be updated to enhance information needed for the medical staff. Study
showed that infection control should be applied in all dental clinics and high quality of dental materials and instruments for preventive measures should be provided. To avoid dental staff anxiety towards dental treatment of corona virus patients' high standard
staff preparation should be provided during dental treatment. |
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Al Omari, O, Al Sabei, et al |
Depression Research and Treatment |
Mental Health |
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A cross-sectional, descriptive design was used to (1) explore the prevalence of depression, anxiety, and stress among
youth and (2) identify to what extent certain variables related to COVID-19 could predict depression, anxiety, and stress (DAS) among young people in six different countries. The total prevalence of depression, anxiety, and stress was 57%, 40.5%, and 38.1%,
respectively, with no significant differences between countries. Significant predictors of stress, anxiety, and depression were being female, being in contact with a friend and/or a family member with mental illness, being quarantined for 14 days, and using
the internet. |
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Albastaki, A, Naji, et al |
Science of the Total Environment |
Epidemiology| Épidémiologie Surveillance |
We tested more than 2900 municipal wastewater samples coming from 49 distinctive area in Dubai, where 28.6% showed
positive results. We also looked into the wastewater samples from 198 commercial aircrafts arriving at Dubai Airport, giving a positive result percentage of 13.6%. This project shows the significance of utilizing wastewater-based epidemiology (WBE) in monitoring
the prevalence of various infectious diseases such as SARS-CoV-2, which can assist the decision makers to determine the level of precautionary measures according to the areas of the outbreak. |
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Ali, K, Rao, et al |
Journal of Primary Care and Community Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study used simple demographic information available on admission to evaluate possible associations between these
variables and outcomes, including mortality and length of stay. Clinical outcomes in 63 patients admitted to a tertiary care hospital in West Texas were reviewed. In summary, age, chronic illness requiring nursing home placement, and acute severe illness requiring
intensive care unit admission identify patients with worse prognoses. In addition, males will likely have a longer length of hospital stay. |
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Ali, SA, Abdelkawi, et al |
Egyptian Journal of Radiology and Nuclear Medicine |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Authors presented their experience in incidental detection of COVID-19-associated pneumonia in asymptomatic patients
coming for routine oncologic 18F-FDG PET/CT examinations during the COVID-19 pandemic, which contribute in the detection of the affected patients early to be isolated and properly managed. 18F-FDG PET/CT is sensitive for early COVID-19 detection, even in asymptomatic
patients that guide proper management and also highlight the key role of a radiologist and the importance of applying safety measures in clinical services during the pandemic to minimize the spread of infection. |
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Ali, Z, Rabiei, et al |
Alexandria Engineering Journal |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this manuscript, a qualitative analysis of the mathematical model of novel coronavirus (COVID-19) involving anew
devised fractal-fractional operator in the Caputo sense having the fractional-order q and the fractal dimension p is considered. The results are tested with real data from COVID-19 outbreak in Wuhan City, Hubei Province of China from 4 January to 9 March 2020.
The Numerical results are presented in terms of graphs for different fractional-order q and fractal dimensions p to describe the transmission dynamics of disease infection. |
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Al-Janabi, A, Elzupir, et al |
Journal of Molecular Structure |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In molecular docking studies with 3-chymotrypsin-like protease (3CLpro), the essential enzyme for SARS-CoV-2 proliferation.
The rest of compounds have shown promising results as 3CLpro inhibitors interacting with the active sites of the enzymes. |
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Serum pooling for rapid expansion of anti-SARS-CoV-2 antibody testing capacity |
Allen, JWL, Verkerke, et al |
Transfusion Clinique et Biologique |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
Examine possible pooling strategies designed to expand SARS-CoV-2 serological testing capacity. Negative pools were
assessed to determine optimal optical density (OD) cutoffs, followed by spiking weak or strong positive samples to assess initial assay performance. Samples were then randomly subjected to pool and individual testing approaches. Single positive specimens consistently
converted pools of 5, 10, or 20 into positive outcomes. However, weaker IgG-positive samples failed to similarly convert pools of 50 to a positive result. In contrast, a stronger individual positive sample converted all pools tested into positive outcomes.
Finally, examination of 150 samples configured into pools of 5, 10, 20 or 50 accurately predicted the presence of positive or negative specimens within each pool. |
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Exploring the effectiveness of a COVID-19 contact tracing app with an agent-based
model |
Almagor, Jonatan, Picascia, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Using an agent-based model, we explore one of the technology-based strategies proposed, a contact-tracing smartphone
app. The model simulates the spread of COVID-19 in a population of agents on an urban scale. Agents are heterogeneous in their characteristics and are linked in a multi-layered network representing the social structure - including households, friendships,
employment and schools. We explore the interplay of various adoption rates of the contact-tracing app, different levels of testing capacity, and behavioural factors to assess the impact on the epidemic. Results suggest that a contact tracing app can contribute
substantially to reducing infection rates in the population when accompanied by a sufficient testing capacity or when the testing policy prioritises symptomatic cases. As user rate increases, prevalence of infection decreases. With that, when symptomatic cases
are not prioritised for testing, a high rate of app users can generate an extensive increase in the demand for testing, which, if not met with adequate supply, may render the app counterproductive. |
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Anxiety and depression during the COVID-19 pandemic in Kuwait: the importance of
physical activity |
Alsharji, KE |
Middle East Current Psychiatry |
Mental Health |
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Investigated the prevalence of anxiety and depression symptoms in Kuwaiti nationals and expats. The study’s secondary
aim was to identify the association between sociodemographic characteristics and physical activity (PA) engagement, with psychological disorders such as anxiety and depression during the COVID-19 pandemic in Kuwait. Results of this study indicated that 53.7%
and 59.6% of the respondents experienced anxiety and depression. The multiple regression models significantly predicted anxiety and depression. In addition, PA, gender, education, and age were significantly associated with anxiety, while PA, gender, age, and
marital status were significantly associated with depression. |
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Prognostic Impact of Prior Heart Failure in Patients Hospitalized With COVID-19 |
Alvarez-Garcia, J, Lee, et al |
Journal of the American College of Cardiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study described the clinical profile and associated outcomes among patients with heart failure (HF) hospitalized
with COVID-19. This study conducted a retrospective analysis of 6,439 patients admitted for COVID-19 at 1 of 5 Mount Sinai Health System hospitals in New York City. History of HF was associated with higher risk of mechanical ventilation and mortality among
patients hospitalized for COVID-19, regardless of left ventricular ejection fraction. |
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Ambrosch, A, Rockmann, et al |
Journal of Infection and Public Health |
Epidemiology| Épidémiologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé |
a monocentric, retrospective study with an interventional character was conducted to investigate the extent to which
the introduction of a strict hygiene bundle including a general mask requirement and daily screening for suspicious patients has an impact on the SARS-CoV-2 nosocomial rate in the pandemic environment in Bavaria. After the introduction of a strict hygiene
bundle, a significant reduction of the nosocomial rate was observed. Furthermore, the risk of spreading hospital-acquired infections also decreased dramatically despite a slow decrease of the hospital COVID 19-prevalence and an increase of infected employees. |
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SARS-CoV-2: Comparative analysis of different RNA extraction methods |
Ambrosi, C, Prezioso, et al |
J Virol Methods |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Herein, we compared the efficiency of RNA extraction of three different commercial kits and an in-house extraction
protocol using synthetic ssRNA standards of SARS-CoV-2 as well as in oro-nasopharyngeal swabs from six COVID-19-positive patients. It was concluded that tested commercial kits can be used with some modifications for the detection of the SARS-CoV-2 genome by
rRT-PCR approaches, although with some differences in RNA yields. Conversely, EXTRAzol reagent was the less efficient due to the phase separation principle at the basis of RNA extraction. |
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Amran, MS |
Int J Soc Psychiatry |
Mental Health |
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The current study aimed to explore psychosocial risk factors associated with mental health of adolescents’ in the midst
of the outbreak by conducting focus group discussions interviews ( n = 15 adolescents from the low income households). The participants adolescents’ psychosocial risk experience during amidst of outbreak of Covid-19 are composed of (1) self- conflict (develop
negative thought at home, unplanned of daily activities, changing sleep pattern and irregular wake up time and massively use internet) (2) Family Members (Conflict between parent and miscommunication between siblings) (3) School (Piling up on homework, Inadequate
guidance for homework and Inability to comprehend online learning). These psychosocial risk factors have caused disruption to daily life adolescents’ during outbreaks and almost inevitably trigger a spike in mental health issues. |
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Anantharaj, Anbalagan, Gujjar, et al |
medRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
Over 95% of the COVID-19 cases are mild-to-asymptomatic who contribute to disease transmission whereas most of the
severe manifestations of the disease are observed in elderly and in patients with comorbidities and dysregulation of immune response has been implicated in severe clinical outcomes. However, it is unclear whether asymptomatic or mild infections are due to
low viral load or lack of inflammation. We have measured the kinetics of SARS-CoV-2 viral load in the respiratory samples and serum markers of inflammation in hospitalized COVID-19 patients with mild symptoms. We observed a bi-phasic pattern of virus load
which was eventually cleared in most patients at the time of discharge. Viral load in saliva samples from a subset of patients showed good correlation with nasopharyngeal samples. Serum interferon levels were downregulated during early stages of infection
but peaked at later stages correlating with elevated levels of T-cell cytokines and other inflammatory mediators such as IL-6 and TNF-alpha which showed a bi-phasic pattern. The clinical recovery of patients correlated with decrease in viral load and increase
in interferons and other cytokines which indicates an effective innate and adaptive immune function in mild infections. We further characterized one of the SARS-CoV-2 isolate by plaque purification and show that infection of lung epithelial cells (Calu-3)
with this isolate led to cytopathic effect disrupting epithelial barrier function and tight junctions. Finally we showed that zinc was capable of inhibiting SARS-CoV-2 infection in this model suggesting a beneficial effect of zinc supplementation in COVID-19
infection. |
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COVID-19 and Anxiety amongst Doctors:
A Pakistani Perspective |
Arshad, AR, Islam, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Mental Health |
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We assess anxiety in Pakistani doctors in context of COVID-19 pandemic and evaluate possible causes. Responses from
431 doctors, including 238 (55.2%) males, were evaluated. Most of them were younger than 30 years (286; 66.4%), in training (335; 77.7%), and working in public hospitals (347; 80.5%). Mild, moderate and severe anxiety was seen in 120 (27.8%), 103 (23.9%) and
42 (9.7%) doctors, respectively. |
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Arslan, G, Yıldırım, et al |
International Journal of Mental Health and Addiction |
Mental Health |
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The current study aims to examine the effect of meaning in life on complete mental health, which represents the presence
of positive functioning and the absence of psychopathological symptoms. The participants of the study included 392 (70.9% female) undergraduate students, and they have predominantly been imposed stay-at-home orders for coronavirus right after announcement
of COVID-19 restrictions in Turkey. Latent variable path analyses demonstrated significant paths from meaning in life to all components of psychological distress, positive mental health, and subjective well-being. Multi-group analysis showed significant gender
differences across the study variables. These findings corroborate the critical role of meaning in life in promoting complete mental health and shed further light on why people high in meaning in life tend to have better mental health than those low in meaning
in life within the context of COVID-19. |
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Arslan, I, Akgul, et al |
SLAS Discov |
Therapeutics| Thérapeutique |
We focus on saporin-based targeted toxins that may be efficacious therapeutic agents for the SARS-CoV-2 infection.
Saporin, a type I ribosome-inactivating protein from soapwort plant, is a potent protein synthesis inhibitor. Catalytically, saporin is a characteristic N-glycosidase, and it depurinates a specific adenine residue from a universally conserved loop of the major
ribosomal RNA (rRNA) of eukaryotic cells. It is well-known that saporin induces apoptosis through different pathways, including ribotoxic stress response, cell signal transduction, genomic DNA fragmentation and RNA abasic lyase (RAlyase) activity, and NAD(+)
depletion by poly-(ADP)-ribose polymerase hyperactivation. Our discussed points suggest that saporin may be a strategic molecule for therapeutic knockout treatments and a powerful candidate for novel drugs in the struggle against COVID-19. |
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Efficacy of honey and Nigella sativa against COVID-19:
HNS-COVID-PK Trial |
Ashraf, Sohaib, Ashraf, et al |
medRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
Investigated efficacy of honey and Nigella sativa (HNS)against COVID-19. Conducted a multicenter-randomized-controlled-trial
in COVID-19 patients. Randomized patients received either honey (1 gm/Kg/day) and Nigella sativa (80 mg/Kg/day) or placebo up to 13 days. Of 313 patients, 210 moderate and 103 severe underwent randomization. Among these 107 were assigned to HNS whereas 103
to placebo for moderate cases. For severe cases, 50 were given HNS and 53 placebo. HNS resulted in symptoms alleviation by 3 and 7 days in moderate and severe disease, respectively (Hazard Ratio [HR]: 6.11 and HR: 4.04, respectively). HNS also cleared the
virus 4 days earlier in moderate (HR: 5.53) and severe cases (HR: 4.32). HNS further led to a better clinical score on day 6 with normal activities in 63.6% moderate (OR: 0.07) and 28% severe (OR: 0.03) patients. A reduction in 30-day mortality among severe
patients was shown with HNS (4% versus 18.87%, OR: 0.18). No HNS-related adverse effects were observed. |
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Asif, S, Frithiof, et al |
Crit Care |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
We investigated the antibody response to SARS-Cov-2 Spike-1 protein in adult patients (n = 19) admitted to the intensive
care unit (ICU) at a tertiary care hospital in Uppsala, Sweden. In our cohort, a IgA, IgG and IgM antibody response could be detected as early as day 0–3 post-ICU admission, and this increase in antibodies was persistent up to day 10–13. A significant change
in antibody concentrations over time was detected in patients who survived till day 30 in comparison with those who did not. No associations were seen between antibody levels and patient age, or any other clinical or laboratory parameters. |
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Atallah, B, Hamour, et al |
Drugs and Therapy Perspectives |
Clinical data| Données cliniques |
Authors report the case of a patient in the United Arab Emirates (UAE) with advanced HF who was glucose-6-phosphate
dehydrogenase deficient and had a history of type 2 diabetes mellitus with diabetic retinopathy and nephropathy, chronic kidney disease stage II, and hyperlipidemia. They outline the logistical, clinical, and pharmacological challenges that the poly-morbid
patient and our HT program in the Middle-East faced under those novel circumstances. |
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Axiotakis, LG, J, et al |
Ann Surg |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
To determine the risk of acquiring perioperative coronavirus disease 2019 (COVID-19) infection in previously COVID-19
negative patients. During the initial peak of the COVID-19 pandemic, there was minimal risk of acquiring symptomatic perioperative COVID-19 infection, especially after the implementation of routine preoperative testing. However, perioperative COVID-19 infection
was associated with poor postoperative outcome. |
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Barage, S, Karthic, et al |
J Biomol Struct Dyn |
Therapeutics| Thérapeutique |
Here, we have employed a series of computer-aided drug repurposing campaign to discover inhibitors of RNA dependent
RNA polymerase (RdRp) and Nsp15/EndoU. Subsequently, MD simulation has been performed to observe dynamic behavior of identified leads at the active site of RdRp and Nsp15. We successfully identified novel lead molecule such as Alectinib for RdRp while Naldemedine
and Ergotamine for NSP15. We propose that the identified inhibitors represent a novel lead molecule to design a more effective inhibitor to stop the progress of pathogen. |
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Barrett, Christine, Cheung, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
This study aimed to investigate knowledge and socio-cognitive perceptions, and their associations with such protective
behaviours, in UK university students. A cross-sectional online survey of 293 students was undertaken on 13 May 2020. Survey questions addressed demographics, knowledge of the disease and effectiveness of the protective measures, risk perception, socio-cognitive
perceptions (e.g. attitude, social support, and self-efficacy), habit, time factors and trust, as well as the hand hygiene and social distancing behaviours. Multiple linear regression was used to identify the strongest associations of potential determinants
with behaviour. articipants reported high levels of social distancing with 88.9 % answering “Mostly” or “Always” for every activity, but only 42.0% reporting the same for all hand hygiene activities. Knowledge of the effectiveness of each activity in preventing
transmission was high, with 90.7% and 93.5% respectively identifying at least 7 of 8 hand hygiene or 9 of 10 social distancing activities correctly. Habit (β = 0.39, p =0.001) and time factors (β = 0.28, p =0.001) were the greatest contributors to unique variance
in hand hygiene behaviour, followed by ethnicity (β = -0.13, p =0.014) and risk perception (β = 0.13, p = 0.016). For social distancing behaviour, the determinants were self-efficacy (β = 0.25, p <0.001), perceived advantages (β = 0.15, p = 0.022), trust in
policy (β = 0.14, p = 0.026) and gender (β = -0.14, p = 0.016). Regression models explained 40% hand hygiene and 25% social distancing variance. |
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Baryakh, EA, Kochneva, et al |
Journal of Modern Oncology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
10 patients with oncohematological pathology associated with new coronavirus infection were observed on the basis of
the hematology service of City Clinical Hospital №52: 59 women and 51 men, mean age 58 (18–90) years. Identification of new coronavirus infection against a backdrop of oncohematological disease is associated with a severe course of COVID-19 and high death
rate – 42%. According to the preliminary obtained results, the adverse prognostic factors of COVID-19 in patients with oncohematological diseases include: elderly age, the poor somatic status (ECOG 3–4), relapse or progression of hemoblastosis and nosological
affiliation to acute leukemia. |
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Basso, RP, Poester, et al |
Mycopathologia |
Clinical data| Données cliniques |
Most reports associating fungal infections with COVID-19 have been cases of invasive aspergillosis. Here, we report
a case of severe histoplasmosis and COVID-19 infections in an HIV patient in Rio Grande, Southern Brazil. Histoplasmosis must be included as a diagnostic possibility in opportunistic fungal co-infections in COVID-19 patients with AIDS, mainly in endemic areas. |
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Autoantibodies against type I IFNs in patients with life-threatening COVID-19 |
Bastard, P, Rosen, et al |
Science (New York, N.Y.) |
Clinical data| Données cliniques Immunology | Immunologie |
We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had
neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs.
The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals.
Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men. |
|
SIRSi compartmental model for COVID-19 pandemic with immunity loss |
Batistela, CM, Correa, et al |
Chaos, Solitons and Fractals |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this study, a Susceptible - Infected - Removed - Sick (SIRSi) compartmental model is proposed. The proposed model
considers the possibility of unreported or asymptomatic cases, and differences in the immunity within a population, i.e., the possibility that the acquired immunity may be temporary, which occurs when adopting one of the parameters (γ) other than zero. The
model is adjusted to the data from three major cities of the state of São Paulo in Brazil, namely, São Paulo, Santos, and Campinas, providing estimations of duration and peaks related to the disease propagation. This study reveals that temporary immunity favors
a second wave of infection and it depends on the time interval for a recovered person to be susceptible again. It also indicates the possibility that a greater number of patients would get infected with decreased time for reinfection. |
|
Baunez, Christelle, Degoulet, et al |
medRxiv |
Public Health Priorities| Priorités de santé publique |
An acceleration index is proposed as a novel indicator to track the dynamics of the COVID-19 in real-time. Using French
data on cases and tests for the period following the first lock-down - from May 13, 2020, onwards - our acceleration index shows that the ongoing pandemic resurgence can be dated to begin around July 7. It uncovers that the pandemic acceleration has been stronger
than national average for the 59-68 and and especially the 69 and older age groups since early September, the latter being associated with the strongest acceleration index, as of October 25. In contrast, acceleration among the 19-28 age group is the lowest
and is about half that of the 69-78, as of October 25. In addition, we propose an algorithm to allocate tests among French departments, based on both the acceleration index and the feedback effect of testing. Our acceleration-based allocation differs from
the actual distribution over French territories, which is population-based. We argue that both our acceleration index and our allocation algorithm are useful tools to guide public health policies as France enters a second lock-down period with indeterminate
duration. |
|
|
First results of investigations of SARS-CoV-2 RNA in human
corneal tissue |
Bayyoud, T, Iftner, et al |
Ophthalmologe |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Preliminary investigations of human corneal tissues from coronavirus disease 2019 (COVID-19) cadaveric donors indicated
that no severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA is present. Current eye banking guidelines do not recommend any type of routine testing for SARS-CoV‑2 RNA in post-mortem donor tissue. This is partly based on factors that can influence
the test results of the reverse transcription polymerase chain reaction (RT-PCR). © 2020, Springer Medizin Verlag GmbH, ein Teil von Springer Nature. |
|
Belikina, DV, Malysheva, et al |
Sovremennye Tehnologii v Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of the investigation was to study the clinical course of COVID-19 in the presence of diabetes mellitus (DM)
and elucidate possible mechanisms of their mutual aggravation. The study included 64 patients with COVID-19; of them, 32 were with DM (main group) and 32 were DM-free (control group). Among patients with DM, the course of viral pneumonia was more severe, as
evidenced by a 2.2-fold higher number of people with extensive (>50%) lung damage (p=0.05), an increased risk of death according to the CURB-65 algorithm (1.3-fold, p=0.043), and a longer duration of insufficient blood oxygen saturation (p=0.0004). With the
combination of COVID-19 and DM, hyperglycemia is persistent, without pronounced variability (MAGE — 1.5±0.6 mmol/L), the levels of C-reactive protein (p=0.028), creatinine (p=0.035), and fibrinogen (p=0.013) are higher, manifestations of hypercoagulability
persist longer, including slower normalization of antithrombin III (p=0.012), fibrinogen (p=0.037), and D-dimer (p=0.035). |
|
|
Benor, Solomon, Abera, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
This cross-sectional online survey was therefore, conducted to appraise the KAP vis-a-vis COVID-19 containment strategy
during May 13-25, 2020. The online survey questionnaire consisted of demographic characteristics and interrogations, pertaining to knowledge (15 items), attitude (10 items) and practices (7 items), framed in accordance to previous studies. A total of 1,484
respondents completed the survey. The overall correct response rating and average score of the knowledge were 74.7 % and 11.2 ± 2.2 respectively. Maximum respondents (63 %) could be bracketed together with a moderate level on knowledge, attitudes while only
43 % had moderate level of practice, with significant difference across demographic variables. Despite the moderate level, the practices were not creditable as the registered values evinced that 1 out of 5 never wore nose mask, washed hands or maintained social
distance. In a similar vein, 17.6 %, and 43.2 % of the respondents were in high and in medium risk of infection, respectively. |
|
|
Modelling and simulating the novel coronavirus with implications of asymptomatic carriers |
Benrhmach, G, Namir, et al |
International Journal of Differential Equations |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
We propose applying a model (SELIAHRD) taking in consideration the number of asymptomatic infected people. The SELIAHRD
model consists of eight stages: Susceptible, Exposed, Latent, Symptomatic Infected, Asymptomatic Infected, Hospitalized, Recovered, and Dead. The asymptomatic carriers contribute to the spread of disease, but go largely undetected and can therefore undermine
efforts to control transmission. The simulation of possible scenarios of the implementation of social distancing shows that if we rigorously follow the social distancing rule then the healthcare system will not be overloaded. |
|
Berenger, BM, Conly, et al |
Clin Microbiol Infect |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We initially investigated saliva collection for SARS-CoV-2 diagnosis via a saline gargle and spit method but found
it to be substantially inferior to a NP swab. PCR-positive individuals admitted to the hospital or in the community diagnosed by a NP or OP swab were consented. Twenty-nine participants (58.6% hospitalized) had a saline gargle sample collected. Using a reference
standard of either sample positive (n=24), the positive agreement for the saline gargle was 70.8% and NP swab 95.8%. In one case, only saliva was positive. The mean time from symptom onset and study collection was 11.6 days (range 3-44). Seventy-five patients
had saliva in UTM collected. The positive agreement for saliva was 84.1% and NP swab 91.3% . The mean time from symptom onset to study collection was 6.59 days (range 0-18). |
|
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Is Cross-Reactive Immunity Triggering COVID-19 Immunopathogenesis? |
Beretta, A, Cranage, et al |
Frontiers in Immunology |
Immunology | Immunologie |
Authors discuss the potential of cross-reactive immunity to drive the immunopathogenesis of COVID-19 and its implications
for current efforts to develop immune-based therapies and vaccines. |
|
Bernard, L, Desoubeaux, et al |
Frontiers in Medicine |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Authors discuss the possibility of the reuse of surgical masks and N95/FFP2 respirators may circumvent the supply chain
constraints and thus overcome mass shortage. Findings provide compelling evidence for the recycling of pre-used surgical masks and N95/FFP2 respirators in case of imminent mass shortfall. |
|
|
Bersanelli, M, Giannarelli, et al |
Therapeutic Advances in Medical Oncology |
Clinical data| Données cliniques |
This prospective, multicentre, observational INVIDIa-2 study is investigating the clinical efficacy of influenza vaccination
in advanced-cancer patients receiving immune-checkpoint inhibitors (ICIs), enrolled in 82 Italian centres, from October 2019 to January 2020. The primary endpoint was the incidence of influenza-like illness (ILI) until 30 April 2020. All the ILI episodes,
laboratory tests, complications, hospitalizations and pneumonitis were recorded. Therefore, the study prospectively recorded all the COVID-19 ILI events. Patients and methods: Patients were included in this non-prespecified COVID-19 analysis, if alive on 31
January 2020, when the Italian government declared the national emergency. From 31 January to 30 April 2020, 66 patients had ILI: 9 of 955 cases were confirmed COVID-19 ILIs, with prevalence of 0.9%, a hospitalization rate of 100% and a mortality rate of
77.8%. The presence of elderly, males and comorbidities was significantly higher among patients vaccinated against influenza versus unvaccinated (p = 0.009, p < 0.0001, p < 0.0001). Overall COVID-19 prevalence was 1.2% for vaccinated (six of 482 cases, all
confirmed) and 1.7% for unvaccinated (8 of 473, 3 confirmed COVID-19 and 5 COVID-like), p = 0.52. COVID-19 has a meaningful clinical impact on the cancer-patient population receiving ICIs, with high prevalence, hospitalization and an alarming mortality rate
among symptomatic cases. Influenza vaccination does not protect from SARS-CoV-2 infection. |
|
|
Besharat, S, Alamdari, et al |
Journal of Cellular and Molecular Anesthesia |
Clinical data| Données cliniques |
In this study, we discuss a 37-year-old man with thoracic aorta trauma caused by a motor–vehicle accident that underwent
Thoracic endovascular aortic repair (TEVAR) and was incidentally diagnosed with concurrent COVID-19. |
|
|
Besutti, Giulia, Ottone, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Clinical data| Données cliniques |
The aim of this study was to develop a prognostic model for death in COVID-19 patients using clinical and CT variables.
Consecutive patients who presented to the emergency room between February 27 and March 23, 2020 for suspected COVID-19, underwent chest CT, and had a positive swab within 10 days were included in this retrospective study. Age, sex, comorbidities, days from
symptom onset, and laboratory data were retrieved from institutional information systems. CT disease extension was visually graded as < 20%, 20-39%, 40-59%, or ≥ 60%. The association between clinical and CT variables with death was estimated with univariable
and multivariable Cox proportional hazards models; model performance was assessed using k-fold cross-validation for the area under the ROC curve (CvAUC). Of the 866 included patients (median age 59.8, women 39.2%), 93 (10.74%) died. Clinical variables significantly
associated with death in multivariable model were age, male sex, HDL cholesterol, dementia, heart failure, vascular diseases, time from symptom onset, neutrophils, LDH, and oxygen saturation level (SO2). CT disease extension was also independently associated
with death (HR=7.56, 95% CI=3.49; 16.38 for ≥ 60% extension). CvAUCs were 0.927 (bootstrap bias corrected-95%CI=0.899-0.947) for the clinical model and 0.936 (bootstrap bias corrected-95%CI=0.912-0.953) when adding CT extension. |
|
|
Bethell, GS, Rees, et al |
BMJ Paediatrics Open |
Healthcare Response | Réponse des soins de santé |
This study aims to report management and outcomes, to date, of children with appendicitis in the UK and Ireland during
the COVID-19 pandemic. Design Survey of consultant surgeons who treat children with appendicitis that informed a prospective multicentre observational cohort study. Setting Data were collected from centres in the UK and Ireland for cases admitted between 1
April and 31 May 2020. This study aims to report management and outcomes, to date, of children with appendicitis in the UK and Ireland during the COVID-19 pandemic. Design Survey of consultant surgeons who treat children with appendicitis that informed a prospective
multicentre observational cohort study. Setting Data were collected from centres in the UK and Ireland for cases admitted between 1 April and 31 May 2020. Results Overall, 326/838 (39%) were initially treated non-operatively of whom 81/326 (25%) proceeded
to appendicectomy within the initial hospital admission. Of cases treated initially surgically 243/512 (48%) were performed laparoscopically. Diagnostic imaging was used in 445/838 (53%) children. |
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Predicting special care during the COVID-19 pandemic: A machine learning approach |
Bezzan, Vitor, Rocco, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins
de santé |
This study proposes an analytical approach based on statistics and machine learning that uses lab exam data coming
from patients to predict whether patients are going to require special care (hospitalisation in regular or special-care units). Also predicted the number of days the patients will stay under such care. The two-step procedure developed uses Bayesian Optimisation
to select the best model among several candidates led to final models that achieved 0.94 area under ROC curve performance for the first target and 1.87 root mean squared error for the second target (which is a 77% improvement over the mean baseline), making
this model ready to be deployed as a decision system. |
|
Efficiency of COVID-19 mobile contact tracing containment by measuring
time-dependent doubling time |
Bianconi, A, Marcelli, et al |
Physical Biology |
Public health interventions*| Interventions de sant&eacute; publique |
We show that the doubling time T d(t) with the success s factor, the characteristic time of the exponential growth
of T d(t) in the arrested regime, is a reliable tool for early predictions of epidemic spread time evolution and provides a quantitative measure of the success of different containment measures. The efficiency of the containment policy lockdown case finding
mobile tracing (LFT) using mandatory mobile contact tracing is much higher than that of the lockdown stop and go policy proposed by the Imperial College team in London. A very low s factor was reached by the LFT policy, giving the shortest time width of the
positive case curve and the lowest number of fatalities. The LFT policy was able to reduce the number of fatalities by a factor of 100 in the first 100 d of the COVID-19 epidemic, reduce the time width of the COVID-19 pandemic curve by a factor 2.5, and rapidly
stop new outbreaks and thereby avoid a second wave to date. |
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Acute pericarditis and severe acute respiratory syndrome coronavirus 2: Case report |
Blagojevic, NR, Bosnjakovic, et al |
International Journal of Infectious Diseases |
Clinical data| Données cliniques |
We present the case of a 51-year-old patient with acute pericarditis as the dominant manifestation of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The patient was admitted to the emergency department during a coronavirus disease 2019 (COVID-19) outbreak with a suspected ST-elevation myocardial infarction. In patients with chest pain, ST elevation
on electrocardiogram, a normal coronary angiogram, and suspected COVID-19, we should think of pericarditis as an unusual presentation of SARS-CoV-2 infection. |
|
Bola, S, Jaikaransingh, et al |
Eur Arch Otorhinolaryngol |
Healthcare Response | Réponse des soins de santé |
As surgical specialties now begin the graduated return to elective activity and face-to-face clinics, this paper investigates
the current head and neck outpatient practices across the United Kingdom. There is a wide variation in outpatient activity across the United Kingdom, but adaptations are being made to try and maintain staff and patient safety. However, more can still be done
by liaising with allied teams to clarify outpatient protocols. |
|
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Optimal control techniques based on infection age for the study of the COVID-19 epidemic |
Bonnans, JF, Gianatti, et al |
Mathematical Modelling of Natural Phenomena |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We propose a model for the COVID-19 epidemic where the population is partitioned into classes corresponding to ages
(that remain constant during the epidemic). The main feature is to take into account the infection age of the infected population. This allows to better simulate the infection propagation that crucially depend on the infection age. |
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Diagnostic accuracy of X-ray versus CT in COVID-19: a propensity-matched database
study |
Borakati, A, Perera, et al |
BMJ Open |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
OBJECTIVES: To identify the diagnostic accuracy of common imaging modalities, chest X-ray (CXR) and CT, for diagnosis
of COVID-19. OBJECTIVES: To identify the diagnostic accuracy of common imaging modalities, chest X-ray (CXR) and CT, for diagnosis of COVID-19 in the general emergency population in the UK and to find the association between imaging features and outcomes
in these patients. DESIGN: Retrospective analysis of electronic patient records. between 16 March and 16 April 2020. RESULTS: Sensitivity and specificity of CXR for COVID-19 diagnosis were 0.56 and 0.60, respectively. For CT scans, these were 0.85 and 0.50,
respectively. This gave a statistically significant mean increase in sensitivity with CT of 29% compared with CXR. |
|
Borges, GM, Crespo, et al |
Cadernos de Saude Publica |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to characterize risk groups for COVID-19 in Brazil and to estimate the number of individuals living
in the same household with persons in the risk group. The results show that age is the principal risk factor for comorbidities associated with COVID-19, but the risk is also greater for persons in more vulnerable categories, such as those with less schooling
and blacks and browns. An estimated 68.7% of Brazilians were living with at least one person in the risk group: 30.3% lived with at least one elderly individual and another 38.4% had no elderly individuals in their households, but there was at least one adult
resident with preexisting medical conditions. |
|
|
Seroprevalence of SARS-CoV-2 IgM and IgG antibodies in an asymptomatic population in
Sergipe, Brazil |
Borges, LP, Martins, et al |
Revista Panamericana de Salud Publica/Pan American Journal of Public Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Objective. To estimate the prevalence of SARS-CoV-2 antibodies in an asymptomatic population in the state of Sergipe,
Brazil. Methods. This cross-sectional study with stratified sampling (sex and age) included serological immunofluorescent tests for IgM and IgG on samples from 3 046 asymptomatic individuals. Results. Of the valid samples, 347 tested positive for IgM and 218
tested positive for IgG. Women over 40 had the highest prevalence for IgM. The most prevalent comorbidities were hypertension (64/123 individuals) and diabetes (29/123). |
|
Borghi, MO, Beltagy, et al |
Frontiers in Immunology |
Clinical data| Données cliniques Immunology | Immunologie |
The objective of this study was to evaluate the prevalence and the clinical association of anti-phospholipid antibodies
(aPLs) in a large cohort of COVID-19 patients, and to characterize the epitope specificity of anti-β2GPI antibodies. aPL show a low prevalence in COVID-19 patients and are not associated with major thrombotic events |
|
|
Boselli, E, Fatah, et al |
J Clin Monit Comput |
Clinical data| Données cliniques |
The purpose of this study was to assess Analgesia/Nociception Index (ANI) and bispectral index (BIS) variations in
supine and prone position during closed-tracheal suction in intensive care unit (ICU) patients with severe COVID-19 pneumonia requiring myorelaxation and prone positioning. Both ANIm and ANIi decreased significantly during tracheal suction with no difference
between positions, whereas BIS showed no significant variation within time and between groups. The median [Q1–Q3] ANIm value decreased from 87 [68–98] to 79 [63–09] in supine position and from 79 [63–95] to 78 [66–98] in prone position 2 min after the beginning
of tracheal suction. The median [Q1–Q3] ANIi value decreased earlier 1 min after the beginning of tracheal suction from 84 [69–98] to 73 [60–90] in supine position and from 84 [60–99] to 71 [51–88] in prone position. Both HR, SBP and SpO2 varied modestly but
significantly during tracheal suction with no difference between positions. |
|
|
Botero, DMR, Omar, et al |
Arteriosclerosis, Thrombosis, and Vascular Biology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective study examined the demographic, clinical, and laboratory characteristics of COVID-19 patients. Patients
were subdivided into ≤55 and >55 years of age. Of 1207 COVID-19-positive patients, 157 met the study criteria (80≤55 and 77>55 years of age). Most reliable predictors of outcomes overall and in subgroups were age, initial and follow-up d-dimer, and LDH (lactate
dehydrogenase) levels. Their predictive cutoff values were used to construct a cluster model that produced 3 main clusters. Cluster 1 was a low-risk cluster and was characterized by younger patients who had low thrombotic and inflammatory features. Cluster
2 was intermediate risk that also consisted of younger population that had moderate level of thrombosis, higher inflammatory cells, and inflammatory markers. Cluster 3 was a high-risk cluster that had the most aggressive thrombotic and inflammatory feature. |
|
|
Botti, C, Lusetti, et al |
Auris Nasus Larynx |
Clinical data| Données cliniques |
This study compared the complication rates and offer an assessment of relative risks and benefits of (percutaneous
dilatational tracheotomy PDT] versus open surgical tracheotomy OST]) in patients with severe COVID-19. Seventeen patients underwent PDT and 30 patients were submitted to OST. Twenty-six patients (55.3%) had post-operative complications (local infection, hemorrhage,
subcutaneous emphysema) with no significant difference between PDT and OST. |
|
|
Boukli, N, Le Mene, et al |
Journal of clinical microbiology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We evaluated the first chemiluminescent microparticle immunoassay (CLIA) available for routine use in Saint-Antoine
Hospital (Paris, France), the Liaison SARS-CoV-2 S1/S2 IgG assay, which uses a combination of SARS-CoV-2 recombinant S1 and S2 proteins as capture antigens. According to delay from symptom onset, clinical sensitivity was 24.1% for 1 to 7 days (7/29), 54.7%
for 8 to 14 days (41/75), and 75% after day 15 (30/40). Furthermore, we were alerted by a high incidence (10%) of false-positive results, which led our laboratory to stop the routine use of this assay. According to the delay from symptom onset, clinical sensitivity
of the Alinity I assay was better than that of the Liaison assay |
|
|
Comparative Performance of Private Equity-Owned US Nursing Homes During
the COVID-19 Pandemic |
Braun, RT, Yun, et al |
JAMA network open |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
The objective of this study was to evaluate the comparative performance of private equity (PE)-owned nursing homes
on COVID-19 outcomes. In this cross-sectional study of 11 470 US nursing homes, there were no statistically significant differences in staffing levels, COVID-19 cases or deaths, or deaths from any cause between PE nursing homes and facilities with other ownership
types. Compared with PE, all other ownership types were more likely to have at least a 1-week supply of N95 masks and medical gowns. |
|
Brochot, E, Demey, et al |
Frontiers in Microbiology |
Clinical data| Données cliniques Immunology | Immunologie |
We monitored the anti-SARS-CoV-2 antibody response in infected patients. In order to assess the time of seroconversion,
we used 151 samples from 30 COVID-19 inpatients and monitored the detection kinetics of anti-S1, anti-S2, anti-RBD and anti-N antibodies with in-house ELISAs. We observed that specific antibodies were detectable in all inpatients 2 weeks post-symptom onset
and that the detection of the SARS-CoV-2 Nucleocapsid and RBD was more sensitive than the detection of the S1 or S2 subunits. Using retroviral particles pseudotyped with the spike of the SARS-CoV-2, we also monitored the presence of neutralizing antibodies
in these samples as well as 25 samples from asymptomatic individuals that were shown SARS-CoV-2 seropositive using commercial serological tests. Neutralizing antibodies reached a plateau 2 weeks post-symptom onset and then declined in the majority of inpatients
but they were undetectable in 56% of asymptomatic patients. |
|
|
Two-component spike nanoparticle vaccine protects macaques
from SARS-CoV-2 infection |
Brouwer, PhilipJM, Brinkkemper, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins Animal model | Modèle animal |
This study presents a two-component protein-based nanoparticle vaccine that displays multiple copies of the SARS-CoV-2
spike protein. Immunization studies show that this vaccine induces potent neutralizing antibody responses in mice, rabbits and cynomolgus macaques. The vaccine-induced immunity protected macaques against a high dose challenge, resulting in strongly reduced
viral infection and replication in upper and lower airways. These nanoparticles are a promising vaccine candidate to curtail the SARS-CoV-2 pandemic. |
|
Buckholz, AP, Kaplan, et al |
Mayo Clinic proceedings |
Clinical data| Données cliniques |
We describe a series of 6 patients with severe rhabdomyolysis associated with COVID-19 to better understand an unusual
but important manifestation of the novel disease. |
|
|
Synchronization in Epidemic Growth and the Impossibility
of Selective Containment |
Budich, Jan Carl, Bergholtz, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique |
Study a simple model of epidemic dynamics separating the population into two groups, namely a low-risk group and a
high-risk group, for which different strategies are pursued. Due to synchronization effects, we find that maintaining a slower epidemic growth behavior for the high-risk group is unstable against any finite coupling between the two groups. More precisely,
the density of infected individuals in the two groups qualitatively evolves very similarly, apart from a small time delay and an overall scaling factor quantifying the coupling between the groups. Hence, selective containment of the epidemic in a targeted
(high-risk) group is practically impossible whenever the surrounding society implements a mitigated community-spreading. We relate our general findings to the ongoing COVID-19 pandemic. |
|
Buehrle, DJ, Decker, et al |
Antimicrobial Agents and Chemotherapy |
Healthcare Response | Réponse des soins de santé |
There are scant data on the impact of COVID-19 on hospital antibiotic consumption, and no data from outside epicenters.
At our nonepicenter hospital, antibiotic days of therapy (DOT) and bed days of care (BDOC) were reduced by 151.5/month and 285/month, respectively, for March to June 2020 compared to 2018-2019 (P = 0.001 and P < 0.001). DOT per 1,000 BDOC was increased (8.1/month;
P = 0.001). COVID-19 will impact antibiotic consumption, stewardship, and resistance in ways that will likely differ temporally and by region. |
|
|
Burgos-Artizzu, Xavier |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Evaluated the performance of Deep Learning methods to detect covid -19 from X-Ray chest images. Chest X-Ray (CXR) images
collected from confirmed covid-19 cases in several different centers and institutions and available online were downloaded and combined together with images of healthy patients and patients suffering from bacterial pneumonia found in other online sources.
Seven different online data sources were combined for a total of N=16,665 patients (3,156 with covid-19, 2,311 with bacterial pneumonia and 11,198 healthy patients). When half of the patients (N=8,331) where used to train the classifier leaving the other half
(N=8,334) for validation, the classifier reached an Area Under the Curve (AUC) for covid-19 detection of 98.6% (detection rate of 91.8% at 1.1% false positive rate). Results were similar for other training/validation splits. AUC was close to 90% even when
tested on patients from a source not used to train the classifier. |
|
|
Neuromuscular involvement in COVID-19 critically ill patients |
Cabañes-Martínez, L, Villadóniga, et al |
Clinical Neurophysiology |
Clinical data| Données cliniques |
The aim of this study was to determine the presence of myopathy, neuropathy or both in ICU patients affected by COVID-19
and whether ICUAW associated with COVID-19 differs from other aetiologies. Methods: Twelve SARS CoV-2 positive patients referred with the suspicion of critical illness myopathy (CIM) or polyneuropathy (CIP) were included between March and May 2020. Results:
Four patients presented signs of a sensory-motor axonal polyneuropathy and seven patients showed signs of myopathy. One muscle biopsy showed scattered necrotic and regenerative fibres without inflammatory signs. The other two biopsies showed non-specific myopathic
findings. |
|
Predictive nomogram for severe COVID-19 and identification of mortality-related
immune features |
Cai, L, Zhou, et al |
J Allergy Clin Immunol Pract |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A predictive nomogram based on risk factors for severe COVID-19 was constructed using the primary cohort and evaluated
internally and externally. The risk prediction nomogram incorporating age, C-reactive protein, and D-dimer for early identification of severe COVID-19 patients showed favorable discrimination in both the primary (AUC 0.807) and validation cohorts (AUC 0.902)
and was well calibrated. Patients who died from COVID-19 showed lower abundance of peripheral CD45RO+CD3+ T cells and natural killer cells, but higher neutrophil counts than that in the patients who recovered (P=0.001, P=0.009, and P=0.009, respectively).
Moreover, the abundance of CD45RO+CD3+ T cells, neutrophil-to-lymphocyte ratio, and neutrophil-to-natural killer cell ratio were strong indicators of death in severe COVID-19 patients (AUC 0.933 for all three). |
|
Candeloro, E, Carimati, et al |
Frontiers in Neurology |
Healthcare Response | Réponse des soins de santé |
This report describes the Neurology and Stroke Unit (SU) of the hospital of Varese had to serve as a cerebrovascular
hub during the COVID-19 outbreak. In 42 days, 46 stroke patients were admitted to our hospital, and 34.7% of them underwent IVT and/or EVT, which means that we treated 0.38 patients per day; in the baseline period from 2016 to 2018, these same figures had
been 23.5% and 0.23, respectively. The mean values of the door-to-first CT/MRI and the door-to-groin puncture, but not of the onset-to-door and the door-to-needle periods were slightly but significantly longer than those observed in the baseline period in
276 patients. |
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|
Cantor, J, Stein, et al |
J Addict Med |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to quantify the availability of telehealth services at substance use treatment facilities
in the U.S. at the beginning of the COVID-19 pandemic, and determine whether telehealth is available at facilities in counties with the greatest amount of social distancing Approximately 27% of substance use facilities in the U.S. reported telehealth availability
at the outset of the pandemic. Treatment facilities in counties with a greater social distancing were less likely to possess telemedicine capability. Similarly, nonopioid treatment programs that offered buprenorphine or vivitrol in counties with a greater
burden of COVID-19 were less likely to offer telemedicine when compared to similar facilities in counties with a lower burden of COVID-19. |
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Carrasco-Sánchez, FJ, López-Carmona, et al |
Ann Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in
non-critically patients hospitalized with COVID-19. Of the 11,312 patients, only 2128 (18.9%) had diabetes and 2289 (20.4%) died during hospitalization. The in-hospital mortality rates were 15.7% (180 mg/dL), p180 mg/dL), p180 mg/d L: HR 1.50; 95% CI: 1.31-1.73)
(BG 140-180 mg/dL; HR 1.48; 95% CI: 1.29-1.70). Hyperglycaemia was also associated with requirement for mechanical ventilation, intensive care unit (ICU) admission and mortality. |
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Carvalho, HEF, Schneider, et al |
Revista brasileira de enfermagem |
Epidemiology| Épidémiologie |
This study was conducted to study the presence of flu-like syndrome suggestive of COVID-19 in men who have sex with
men (MSM) and engaged in casual sex during a period of social isolation. There was a statistical difference (p < 0.001) in the average of partners between those who had signs and symptoms of flu-like syndrome (3.5) and those who did not (1.7). |
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Casini, B, Tuvo, et al |
Int J Environ Res Public Health |
Healthcare Response | Réponse des soins de santé |
This paper reports the experience of the University Hospital of Pisa in managing the risk from severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) during an endoscopy. A review of the reprocessing procedure was conducted to assess whether improvement actions were needed. To verify the reprocessing efficacy, a virological analysis was conducted both before and after
the procedure. Five bronchoscopes and 11 digestive endoscopes (6 gastroscopes and 5 colonoscopes) were sampled. The virological analysis carried out on samples collected from endoscopes after reprocessing gave negative results, as well as on samples collected
on the endoscopy column surfaces and the two washer-disinfectors that were dedicated to COVID-19 patients. The improvement in endoscope reprocessing implemented during the COVID-19 emergency was effective in ensuring the absence of SARS-CoV-2, thus reducing
the risk of infections after an endoscopy on COVID-19 patients. |
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Catalan-Matamoros, D, Elías, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
The objective of this study was to examine media sourcing patterns as well as a review of vaccines as a case-study.
Articles were retrieved from the national quality press in Spain. Content analysis was undertaken on the sources and on other variables such as tone, frames and journalistic genre. Findings indicate that sources related to the government, professional associations
and scientific companies are the most frequently used, confirming the central role of government institutions as journalistic sources. These were followed by university scientists, scientific journals and clinicians. On the other hand, NGOs and patients groups
were included in fewer than 5% of the articles. More than 30% included none or just one source expressing unbalanced perspectives. |
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Chan, S, Chu, et al |
Physica A: Statistical Mechanics and its Applications |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The authors investigate whether it is possible to fit count regression models to the number of daily new cases of COVID-19
in various countries and make short term predictions of these numbers. The results suggest that the biggest advantage of these methods is that they are simplistic and straightforward allowing us to obtain preliminary results and an overall picture of the trends
in the daily confirmed cases of COVID-19 around the world. The best fitting count regression model for modelling the number of new daily COVID-19 cases of all countries analysed was shown to be a negative binomial distribution with log link function. Whilst
the results cannot solely be used to determine and influence policy decisions, they provide an alternative to more specialised epidemiological models and can help to support or contradict results obtained from other analysis. |
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Charan, J, Bhardwaj, et al |
Indian Journal of Clinical Biochemistry |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study included 725 patients from an Isolation center in order to assess the use of Complementary and Alternative
Medicine (CAM) or home remedies to treat COVID-19. A total of 495 participants responded, of which 367 (74.1%) had not used any Complementary and Alternative Medicine (CAM) product or home remedies while 128 (25.8%) people used 161 CAM products and home remedies
during the treatment and even afterward. More than half of the participants (59.6%) among them had consumed Ayurvedic Kadha. Many respondents consumed more than one CAM products or home remedies but there were no reported acute or severe adverse effects with
these products. |
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|
Chari, A, Samur, et al |
Blood |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective study describes the baseline characteristics and outcome data of COVID-19 infection in 650 patients
with plasma cell disorders, in particular, multiple myeloma(MM). Among hospitalized patinets, the median age was 69 years, and nearly all patients(96%) had MM. Approximately, 36% were recently diagnosed(2019-2020), and 54% of patients were receiving first-line
therapy. Thirty-three percent of patients have died, with significant geographic variability, ranging from 27% to 57% of hospitalized patients. Univariate analysis identified age, ISS3, high-risk disease, renal disease, suboptimal myeloma control(active or
progressive disease), and one or more comorbidities as risk factors for higher rates of death. Multivariate analysis found that only age, high-risk MM, renal disease, and suboptimal MM control remained independent predictors of adverse outcome with COVID-19
infection. |
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Chen, SY, Lee, et al |
Emerg Microbes Infect |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This multicenter, retrospective study evaluated the performance of five anti-severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) antibody tests. Data suggested that understanding the dynamic antibody response after COVID-19 infection and performance characteristics of different serological test are crucial for the appropriate interpretation of serological test result
for the diagnosis and risk assessment of patient with COVID-19 infection. |
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Chen, X, Zhao, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
METHODS: This study enrolled 48 patients with COVID-19 admitted to the General Hospital of Central Theater Command,
People's Liberation Army, a designated hospital in Wuhan, China. The patients were divided into 3 groups according to the Diagnosis and Treatment of New Coronavirus Pneumonia. RESULTS: Analysis of clinical characteristics of 48 cases of COVID-19 showed that
RNAemia was diagnosed only in the critically ill group and seemed to reflect the severity of the disease. Furthermore, the level of the inflammatory cytokine IL-6 in critically ill patients increased significantly, almost 10 times that in other patients. More
importantly, the extremely high IL-6 level was closely correlated with the detection of RNAemia. |
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Comparison of the evolution of the COVID‐19 disease between Romania and Italy |
Chiruţă, C, Bulgariu, et al |
Applied System Innovation |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Based on the time‐dependent susceptible– infected–recovered—SIR model, this paper compares the evolution of the COVID‐19
disease between Romania and Italy, assuming that the parameter value of R0 in the time‐dependent SIR model decreases to R1 < R0 after publicly announced restrictions by the government, and increases to a value of R2 < R1 when the restrictions are lifted. |
|
Choi, W, Shim, et al |
J Theor Biol |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
We developed a game-theoretic epidemiological model that considers vaccination and social distancing under the assumption
that individuals pursue the maximization of payoffs. By using this model, we identified the individually optimal strategy based on the Nash strategy when both strategies are available and when only one strategy is available. Furthermore, we determined the
relative costs of control strategies at which individuals preferentially adopt vaccination over social distancing (or vice versa). |
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Chou, WP, Wang, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
This study aimed to determine the proportion of individuals who voluntarily reduced interaction with their family members,
friends, and colleagues or classmates to avoid coronavirus disease 2019 (COVID-19) infection and the associations of reduced social interaction with perceived social support during the COVID-19 pandemic in Taiwan. Moreover, the related factors of voluntary
reduction of social interaction were examined. The present study revealed that despite strict social distancing measures not being implemented in Taiwan, more than one-third of respondents voluntarily reduced their interaction with friends and colleagues
or classmates. |
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Multicenter Analysis of Liver Injury Patterns and Mortality in COVID-19 |
Chu, H, Bai, et al |
Frontiers in Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of our study was to determine risk factors for different liver injury patterns and to evaluate the relationship
between liver injury patterns and prognosis in patients with COVID-19. Our study confirmed that hepatocellular injury pattern that may be induced by hypoxia was not risk factor for mortality in SARS-COV-2 infection, while liver injury with mixed pattern and
cholestatic pattern that might be induced by SARS-CoV-2 directly might be potential risk factors for increased mortality in COVID-19 patients. |
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The duration of SARS-CoV-2 shedding in patients recovering from COVID-19 |
Cimrman, Š, Macková, et al |
Epidemiologie, Mikrobiologie, Imunologie |
Clinical data| Données cliniques |
The knowledge of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) shedding is highly relevant to the diagnosis,
treatment and follow-up of patients with COVID-19 (coronavirus disease 2019). Deep nasopharyngeal swabs repeatedly collected from a cohort of one hundred patients with COVID-19 were tested for SARS-CoV-2 RNA using RT-PCR (real-time polymerase chain reaction).
The median period of viral genome detectability was 15 days. Furthermore, the authors tested the hypothesis on the relationship between the severity of COVID-19 and the period in which the viral genome is detectable. They did not find any statistically significant
difference in the duration of viral clearance between patients with asymptomatic to mild disease or severe disease. © 2020, Czech Medical Association J.E. Purkyne. All rights reserved. |
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Codeluppi, L, Venturelli, et al |
Brain Behav |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
OBJECTIVE: To compare the incidence and clinical features of individuals presenting in emergency rooms (ER) with facial
palsy during the Italian COVID-19 outbreak and in the same period of 2019. METHODS: We retrospectively reviewed the medical records for all accesses to the six ER in the province of Reggio Emilia, Italy, during the first phase of the COVID-19 pandemic (27
February-3 May 2020). RESULT: Of the 2020 cohort, eight patients (21%) presented with active or recent symptoms consistent with COVID-19 infection, compared with 2 (9%) in 2019 (p = .299); one was tested and resulted positive for SARS-CoV-2. |
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Cofré, RM, Madrid, et al |
International Journal of Morphology |
Clinical data| Données cliniques |
The objective of this research was to explore the relationship of ventilatory mechanics and radiographic measures with
the time of connection to MV in COVID-19 patients. Retrospective study, which included 23 patients on MV. Findings show that the pressure resulting from the programming of the mechanical ventilator (MV), together with the structural changes observed in the
RT, are related to the time of connection to MV. |
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Containment of a COVID-19 Outbreak in an Inpatient Geriatric Psychiatry Unit |
Constantino-Shor, C, Rani, et al |
J Am Psychiatr Nurses Assoc |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Here we describe infection control and nursing-led interventions that were quickly enacted in response to this SARS-CoV-2
outbreak in an inpatient geriatric psychiatry unit. The interventions effectively contained the outbreak, with no further patients and only one staff member testing positive for SARS-CoV-2 over the subsequent 2-month time period. |
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Outbreak diversity in epidemic waves propagating through distinct geographical scales |
Costa, GuilhermeS, Cota, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
A central feature of an emerging infectious disease in a pandemic scenario is the spread through geographical scales
and the impacts on different locations according to the adopted mitigation protocols. This study investigated a stochastic epidemic model with the metapopulation approach in which patches represent municipalities. As a case of study, the epidemic of COVID-19
in Brazil was used performing data-driven simulations. Correlations between delay of the epidemic outbreak and distance from the respective capital cities were predicted to be strong in several states and weak in others, signaling influences of multiple epidemic
foci propagating towards the inland cities. |
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Cuñarro-López, Y, Cano-Valderrama, et al |
J Clin Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study was designed to examine maternal-perinatal outcomes in pregnant women with suspected COVID-19 according
to the result of a real-time RT-PCR test and to investigate possible variables that could be useful for predicting a negative RT-PCR result. The predictive model for a negative test result included the monocyte count, LDH level and no need for oxygen therapy.
This model was able to identify 73.5% of patients with a negative RT-PCR result. Only 11% of the patients with pneumonia testing negative for the virus had IgG antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The proportion
of pregnant women with suspected COVID-19 and a negative RT-PCR result was nearly 39%. In these patients, the symptoms were mild and the systemic severity of the disease was lower. The monocyte count, LDH level and no need for oxygen therapy were the factors
that were more related to a negative test result in this group. |
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Cusack, DA |
Journal of Forensic and Legal Medicine |
Epidemiology| Épidémiologie |
This observational study was carried out to chronicle and analyse the total number of deaths notified to the Coroner
during the period January through June 2020 in Kildare, Ireland. The calculated excess number of deaths notified for January to June 2020 compared with 2015–2019 was 198 (41%) of the 484 total deaths reported with a 131 (45%) excess in the 293 deaths in nursing
and residential homes. Covid-19 deaths accounted for 70% and 86% of these excess deaths respectively. Underlying medical conditions were recorded in 99% of those dying from Covid-19 and the average age of the deceased was 82.5 years. |
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Safely reducing haemodialysis frequency during the COVID-19 pandemic |
da Silva Lodge, Michelle, Abeygunaratne, et al |
Research Square prepub |
Clinical data| Données cliniques |
Dialysis unit nephrologists identified 166 suitable patients (38.4% of our HD population) to temporarily convert to
twice-weekly haemodialysis immediately prior to the peak of the COVID-19 pandemic in our area. Changes in pre-dialysis weight, systolic blood pressure (SBP) and biochemistry were recorded weekly throughout the 4-week project. Hyperkalaemic patients (serum
potassium > 6.0mmol/L) were treated with a potassium binder, sodium bicarbonate and received responsive dietary advice. There were 12 deaths (5 due to COVID-19) in the HD population, 6 of which were in the twice weekly HD group; no deaths were associated with
change of dialysis protocol. A further 19 patients were either hospitalised and/or developed COVID-19 and thus transferred back to thrice weekly dialysis as per protocol. Of 141 eligible patients 113 (80.1%) were still receiving twice-weekly HD by the end
of the 4-week project. Indications for transfer back to thrice weekly were; fluid overload (19), persistent hyperkalaemia (4), patient request (4) and compliance (1). There were statistically significant increases in SBP and pre-dialysis potassium during the
project. |
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Psychological distress and adaptation to the COVID-19 crisis in the United
States |
Daly, M, Robinson, et al |
Journal of psychiatric research |
Mental Health |
|
In this observational population-based study, we examined how psychological distress changed following the emergence
of the COVID-19 crisis in the United States and tested whether certain population subgroups were vulnerable to persistent distress during the crisis. We analyzed longitudinal nationally representative data from eight waves of the Understanding America Study
(UAS) collected between March 10th and July 20th, 2020 (N = 7319 Observations = 46,145). This study identified substantial increases in distress in the US during the emergence of the COVID-19 crisis that largely diminished in the weeks that followed and suggests
that population level resilience in mental health may be occurring in response to the pandemic. |
|
Darvishi, E, Golestan, et al |
Activitas Nervosa Superior |
Mental Health |
|
The present study was conducted aiming to evaluate the prevalence of OCD and cognitive errors among young people during
the outbreak of coronavirus disease 2019. The present study is a descriptive, cross-sectional study in which a total of 150 young people aged 13 to 19 were randomly included. The results revealed that 67.3% of the subjects who were evaluated may have demonstrated
OCD symptomatology. The prevalence of obsessive-compulsive disorder symptoms in women was slightly higher than in men (72.1 compared to 60.3%). Likewise, the test results indicated that there was a significant difference between obsessive-compulsive disorder
symptom in men and women (p =.001). There was also a significant difference between the two groups with OCD symptoms and without OCD symptoms in all the components of cognitive errors (p =.001). |
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Influence of tocilizumab on the outcome of patients with covid-19. Retrospective
observational study |
Davidescu, EI, Odajiu, et al |
Farmacia |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Authors aim was to determine whether cytokine storm could potentiate a favourable outcome in such patients. Tocilizumab
might be regarded as a valuable drug in the management of severe SARS-CoV-2 infection. |
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Tunicamycin anticancer drug may reliable to treat coronavirus disease-19 |
Dawood, AA, Alnori, et al |
Open Access Macedonian Journal of Medical Sciences |
Therapeutics| Thérapeutique |
BACKGROUND: SARS-CoV-2 outbreaks remains a medical and economic challenge, due to the lack of a suitable drug or vaccine.
The glycan in some proteins plays an important role in protein folding, sorting, transport, and oligomerization, so the hindering of N-linked glycosylation of glycoproteins will prevent assembly of the virion. Tunicamycin anticancer drug inhibits the N-linked
glycan. AIM: This study aimed to find out the mechanism action of tunicamycin on the viral glycoproteins. RESULTS: The growth of the virus in the presence of tunicamycin conducted in the production of non-infectious and absence of spike protein (spikeless
virions). Tunicamycin inhibits E2, S, and M glycoproteins of coronaviruses. Tunicamycin has also diminished glycosylation of PTMs such as HE, and 8ab of SARS-CoV. Finally, CONCLUSION: This study recommends using this drug to treat the SARS-CoV-2. © 2020 Ali
Adel Dawood, Haitham Abdul-Malik Alnori. |
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Emerging fiscal health and governance concerns resulting from COVID-19 challenges |
de Jong, M, Ho, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Economics | Économie |
This study analyzes the scope and magnitude of the budgetary responses of 17 developed countries to the COVID-19 pandemic
and examines whether policy responses in March–June, 2020 are correlated with economic and fiscal conditions in these countries. This study shows that budgetary and fiscal responses to the COVID-19 pandemic varied in magnitude but had many similarities in
policy types across countries. The magnitude of the response is not significantly correlated with fiscal conditions but is positively correlated with the pandemic caseload and negatively with medium-term expenditure planning, healthcare spending and anticipated
unemployment changes. |
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COVID-19 in chronic hemodialysis patients: A report of 9 cases in Madrid, Spain |
de la Flor Merino, JC, Valga Amado, et al |
Clin Nephrol |
Clinical data| Données cliniques |
We present one of the first case series of chronic hemodialysis patients with COVID-19. Between March 14 and April
8, 2020, out of 76 prevalent patients in our hemodialysis unit, 9 (11.8%) patients were diagnosed with COVID-19. The most common symptoms were fever (77.8%), asthenia (77.8%), cough (55.6%), and dyspnea (33.3%). A total of 3 patients developed severe pneumonia,
whereas 4 patients developed mild pneumonia. In 2 patients, no pathologic changes were found on chest radiography. All patients presented lymphopenia. |
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Impact of COVID-19 Pandemic on Mechanical Reperfusion for Patients With STEMI |
De Luca, G, Verdoia, et al |
Journal of the American College of Cardiology |
Healthcare Response | Réponse des soins de santé |
The ISACS-ST-segment elevation myocardial infarction (STEMI) COVID-19 registry aims to estimate the true impact of
the COVID-19 pandemic on the treatment and outcome of patients with STEMI treated by primary percutaneous coronary intervention (PPCI), with identification of “at-risk” patient cohorts for failure to present or delays to treatment. The COVID-19 pandemic had
significant impact on the treatment of patients with STEMI, with a 19% reduction in PPCI procedures, especially among patients suffering from hypertension, and a longer delay to treatment, which may have contributed to the increased mortality during the pandemic. |
|
de Matos, DG, Aidar, et al |
Sustainability (Switzerland) |
Mental Health |
|
It was aimed to analyze the effects of COVID-19 quarantine on physical activity levels, energy expenditure, quality
of life, and level of stress in a sample of the Brazilian population. The sample included 426 participants (7 to 80 years). During the pandemic, 84% of the sample indicated a low level of physical activity. Furthermore, weekly energy expenditure decreased
significantly in all age groups during the pandemic (children p < 0.0001; adolescents: p < 0.0001; adults p < 0.001, and elderly p < 0.0001). All aspects of quality of life, significantly reduced in both sexes in all age groups (p < 0.05). With the exception
of children, stress levels increased significantly during the pandemic (adolescents: male: p = 0.003, female: p < 0.05; adults: male: p = 0.003, female: p = 0.01, and elderly: male: p = 0.02, female: p = 0.03). |
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Dejaco, C, Alunno, et al |
Ann Rheum Dis |
Healthcare Response | Réponse des soins de santé |
This study aimed to investigate how the first wave of COVID-19 pandemic influenced decisions of rheumatologists and
health professionals in rheumatology regarding the management of patients with inflammatory rheumatic and musculoskeletal diseases (RMDs). Measures related to containment of COVID-19 pandemic led to a perceived delay between symptom onset and a first rheumatological
visit, postponement of treatment decisions, and shortage of HCQ and TCZ, thereby negatively impacting early treatment and treat-to-target strategies. |
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Antibody binding to SARS-CoV-2 S glycoprotein correlates with but does not predict neutralization |
Ding, S, Laumaea, et al |
Viruses |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
There is heterogeneity in the neutralization capacity of antibodies isolated from SARS-CoV-2-infected individuals.
In this study, a pseudovirus capture assay (VCA) was developed to measure the capacity of plasma samples or immobilized antibodies to bind to membrane-bound S glycoproteins from SARS-CoV-2 expressed at the surface of lentiviral particles. Plasma samples that
were unable to capture viral particles did not neutralize, yet capture did not guarantee neutralization, indicating that the capacity of antibodies to bind to the S glycoprotein at the surface of pseudoviral particles is required but not sufficient to mediate
neutralization. |
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Implementation of a Nurse Practitioner-Led Drive-Through COVID-19 Testing Site |
Dippel, KS, Kelly, et al |
Journal for Nurse Practitioners |
Healthcare Response | Réponse des soins de santé |
We demonstrate that our drive-through model is an efficient method of testing large numbers of patients during a pandemic.
In the drive-through, cost per patient and personal protective equipment use were significantly less than in 3 brick-and-mortar clinics providing testing. We provide an example of effective nurse practitioner leadership in a drive-through testing site. |
|
Do, JY, Kim, et al |
Diabetes Metab |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to evaluate the association between metformin use and clinical outcomes in DM patients with COVID-19.
METHODS: This retrospective study was based on claims data. Patients were divided into three groups depending on metformin use: CON (those not taking DM medication); N-MFOM (those taking DM medications other than metformin); and MFOM (those taking metformin
for DM). RESULTS: Kaplan-Meier analyses showed that MFOM patients had poorer survival rates than those in the CON group, but there were no significant differences in survival rates between MFOM and N-MFOM groups. |
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Du, RH, Liang, et al |
European Respiratory Journal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused
by the novel coronavirus SARS-CoV-2. Authors identified four risk factors: Age 65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells 75 cells μL-1 and cardiac troponin I 0.05 ng mL-1. |
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Delayed dynamics of SIR model for COVID-19 spread forecasting |
Ebraheem, HameedK, Alkhateeb, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Transmission |
Earlier studies of compartmental model of Susceptible-Infected-Recovered (SIR) did not predict the peaking of a hot
spots flairs of viral infections and a new model needed to provide a more realistic results to serve public officials battling the pandemic worldwide. A new modified SIR model which incorporates appropriate delay parameters leading to a more precise prediction
of COVID-19 real time data. The predictions of the new model are compared to real data obtained from four countries, namely Germany, Italy, Kuwait, and Oman. Two included delay periods for incubation and recovery within the SIR model produces a sensible and
more accurate representation of the real time data. The reproductive number
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Face Mask Utilization in the Era of COVID-19: Nigeria Experience |
Edet, Clement Kevin, Harry, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
This study investigated the knowledge and utilization of face masks among the Nigerian population. This was a web-based
cross-sectional survey conducted from July 2 to August 28, 2020 using a convenience sampling technique. This was in adherence to the Nigeria Centre for Disease Control (NCDC) guideline of physical/social distancing. Data was collected using a pre-tested questionnaire.
Descriptive statistics of frequency with percentage were used to present responses. A total of 811 respondents participated in the survey with the mean age of 36.93±12.17 years, out of which 43.8% were male and 56.2% were female. Christians were 94.6%, those
employed were 84.7%, 61.1% attained tertiary education and 50.8% belonged to a household size of 3-5 persons. Almost all the respondents 91.9% and 94% were aware that face masks can reduce the spread of COVID-19 and should be worn in the public respectively.
95.3% of the participants had used a face mask as a protection against COVID-19. Furthermore, 90.2% used face masks in the public, 53% used it when entering restricted places, 45.5% when with a suspected case and 30.7% used a mask due to fear of arrest/punishment.
The majority of respondents used homemade masks (70%) and 71.2% reused their masks. |
|
Cost–benefit of limited isolation and testing in COVID-19 mitigation |
Eilersen, A, Sneppen, et al |
Scientific Reports |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
We propose an agent-based model of disease transmission in a society divided into closely connected families, workplaces,
and social groups. This allows us to discuss mitigation strategies, including targeted quarantine measures. We find that workplace and more diffuse social contacts are roughly equally important to disease spread, and that an effective lockdown must target
both. We examine the cost–benefit of replacing a lockdown with tracing and quarantining contacts of the infected. When reopening society, testing and quarantining is a strategy that is much cheaper in terms of lost workdays than a long lockdown. A targeted
quarantine strategy is quite efficient with only 5 days of quarantine, and its effect increases when testing is more widespread. |
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Ekpenyong, M, Udo, et al |
|
Public health interventions*| Interventions de sant&eacute; publique |
A Spatio-GraphNet model for real-time contact tracing of CoVID-19 infection is proposed in this paper for real-time
crowd source of contacts-using a WiFi-like soft-robot enabled on mobile phones. Once enabled, useful contact tracing parameters can be captured and stored. Using knowledge of Graph Theory, production traces of stored contacts are filtered for efficient contact
tracing, practical disease surveillance and prompt medical/healthcare intervention. Simulation results reveal the contact tracing dashboard with appropriate parameters thresholds, application and evaluation of various statistical kernels as well as practical
implications of the study. |
|
|
Evans, S, Mikocka-Walus, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
The present study uses a qualitative approach to understand the impact of COVID-19 on family life. Australian parents
of children aged 0–18 years were recruited via social media between April 8 and April 28, 2020, when Australians were experiencing social distancing/isolation measures for the first time. As part of a larger survey, participants were asked to respond via an
open-ended question about how COVID-19 had impacted their family. Six themes were derived from the data, including “Boredom, depression and suicide: A spectrum of emotion,” “Families are missing the things that keep them healthy,” “Changing family relationships:
The push pull of intimacy,” “The unprecedented demands of parenthood,” “The unequal burden of COVID-19,” and “Holding on to positivity.” |
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Delayed catastrophic thrombotic events in young and asymptomatic post COVID-19
patients |
Fan, BE, Umapathi, et al |
J Thromb Thrombolysis |
Long-Term Sequelae |
|
This report highlights a series of catastrophic arterial events observed in post COVID-19 patients. During the months
of April 2020 to July 2020, Singapore experienced a surge in COVID-19 cases amongst our migrant workers. Subsequently, 4 young healthy migrant workers previously diagnosed with COVID-19 presented with catastrophic, large arterial thromboses. The remarkable
features of these cases include young age without preexisting cardiovascular risk factors, asymptomatic SARS-CoV-2 infection and the long latency between initial positive serology and their catastrophic vascular event. |
|
Farnós, O, Venereo-Sánchez, et al |
Vaccines (Basel) |
Vaccine Research| Recherche sur les vaccins |
Two methods for rapid, scalable production of SARS-CoV-2 Spike Receptor Binding Domain (RBD) protein for use in subunit
vaccines were compared. RBD production was compared between plasmid transient transfection or human type-5-adenoviral (Ad5) infection of cells. Both methods produced high protein yields with >95% purity, proper conformational structure, recognition by anti-Spike
monoclonal antibodies and efficient binding to ACE2. The Ad5 method led to over 100 µg/mL of RBD in culture supernatants, which was 7-fold higher than levels obtained by transfection. |
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|
Termination of pregnancy in a twin pregnant patient with COVID-19 |
Farsani, HA, Behnaz, et al |
Journal of Cellular and Molecular Anesthesia |
Clinical data| Données cliniques |
In this article, we present a pregnant case of COVID-19 with underlying symptoms of respiratory distress; which was
referred to Shohada-e-Tajrish Hospital. Due to the progressive decrease of O2 saturation, the medical team decided to terminate the pregnancy in order to save the patient's life. Despite all these efforts including pharmaceutical agents, the patient passed
away. |
|
Feng, Q, Li, et al |
Frontiers in Molecular Biosciences |
Clinical data| Données cliniques |
In this study, we identified pathways associated with ACE2 expression and gene co-expression networks of ACE2 in pan-tissue
using the datasets from the Genotype-Tissue Expression (GTEx) project as well as explore ACE2 expression in SARS-CoV-2-infected human tissues using a publicly available RNA-Seq dataset. We found that ACE2 was upregulated in SARS-CoV-2-infected tissues relative
to normal tissues and in SARS-CoV-2-infected males relative to females, while its expression levels had no significant difference between healthy females and males. Numerous immune-related pathways were highly enriched in SARS-CoV-2-infected males relative
to females. These data indicate that males are more susceptible and more likely to have an excessive immune response to SARS-CoV-2 infection than females. |
|
|
Ferrer, M, Mancha, et al |
|
Mental Health |
|
The objective of this study is to evaluate the psychosocial well-being of the students of a Peruvian public university
during the 90 days of social isolation; the method we have used is descriptive - cross-sectional, with a non-probability sample of 285 university students, who filled out an online survey to detect psychosocial symptoms, using the General Health Questionnaire
(GHQ-28); finding that 72.6% of students exposed to a medium-high level of psychosocial risk. In conclusion, an association was found between a medium-high level of psychosocial risk and the variables: cohabiting with people at risk for COVID-19 (Xi2 = 9,661
and p <0.05); present symptoms compatible with COVID-19 19 (Xi2 = 28,957 and p <0.05) and cohabit with COVID-19 patients (Xi2 = 8,803 and p <0.05). |
|
|
Ferretti, AP, Kula, et al |
Immunity |
Coronavirology| Coronavirologie |
We used an unbiased, genome-wide screening technology to determine the precise peptide sequences in SARS-CoV-2 that
are recognized by the memory CD8+ T cells of COVID-19 patients. In total, we identified 3–8 epitopes for each of the 6 most prevalent human leukocyte antigen (HLA) types. These epitopes were broadly shared across patients and located in regions of the virus
that are not subject to mutational variation. Notably, only 3 of the 29 shared epitopes were located in the spike protein, whereas most epitopes were located in ORF1ab or the nucleocapsid protein. We also found that CD8+ T cells generally do not cross-react
with epitopes in the four seasonal coronaviruses that cause the common cold. |
|
|
Filosto, M, Cotti Piccinelli, et al |
J Neurol Neurosurg Psychiatry |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We evaluated incidence and clinical features of Guillian-Barre syndrom (GBS) in a cohort of patients from two regions
of northern Italy with the highest number of patients with COVID-19. This study shows an increased incidence of GBS during the COVID-19 outbreak. Estimated incidence of GBS in COVID-19-positive patients was 47.9/100 000 and in the COVID-19-positive hospitalised
patients was 236/100 000. COVID-19-associated GBS is predominantly demyelinating and seems to be more severe than non-COVID-19 GBS. |
|
|
Delayed positive association between air temperature and covid-19 incidence
in Italy |
Fong, Fang Chyi, Goodson, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction |
This study investigated the association between air temperature and covid-19 incidence. The temperature exposure response
curves generally showed an increased RR with increasing temperature, covid-19 incident rates can be forecast with model generated. |
|
Contribution of VitaPCR SARS-CoV-2 to the emergency diagnosis of COVID-19 |
Fournier, PE, Zandotti, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We evaluated the VitaPCR™ RT-PCR assay, whose sample analysis time is of approximately 20 min, in nasopharyngeal secretions
from 534 patients presenting to our Institute, for the diagnosis of COVID-19, and compared it to our routine RT-PCR assay. The sensitivity, specificity, positive and negative predictive values of VitaPCR™ can be evaluated to be 99.3%, 94.7%, 88.6% and 99.7%,
respectively. Tenfold dilutions of a SARS-CoV-2 strain show that the VitaPCR™ was more sensitive that our routine RT-PCR assay. |
|
Franco, C, Facciolongo, et al |
Eur Respir J |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique
Healthcare Response | Réponse des soins de santé |
Authors aimed to analyse the safety of the hospital staff and the feasibility and outcomes of noninvasive respiratory
support (NRS) applied to patients outside the ICU. The application of NRS outside the ICU is feasible and associated with favourable outcomes. |
|
|
Frenkel, MO, Giessing, et al |
Journal of Criminal Justice |
Mental Health |
|
This mixed-method study investigated officers' strain over a three-month-period after the lockdown. In an online survey,
2567 police officers (77% male) from Austria, Germany, Switzerland, the Netherlands, and Spain participated at three measurement points per country in spring, 2020. On average, officers seemed to tolerate the pandemic with slight decreases in strain over time.
Despite substantial variance between countries, 66% of the variance occurred between individuals. Sex, work experience, stressor appraisal, emotion regulation, and preparedness significantly predicted strain. Risk of infection and deficient communication emerged
as main stressors. |
|
|
Development of a Fluorescence-Based, High-Throughput SARS-CoV-2 3CLpro Reporter Assay |
Froggatt, HM, Heaton, et al |
Journal of virology |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this work, we report a new assay to identify inhibitors of 3CLpro. Our reporter is based on a green fluorescent
protein (GFP)-derived protein that fluoresces only after cleavage by 3CLpro. This experimentally optimized reporter assay allows for antiviral drug screening in human cell culture at biosafety level 2 (BSL2) with high-throughput compatible protocols. Using
this screening approach in combination with existing drug libraries may lead to the rapid identification of novel antivirals to suppress SARS-CoV-2 replication and spread. |
|
No traces of SARS-CoV-2 in wounds of COVID-19 positive patients:A pilot study |
Gaba, S, Kampalli, et al |
Indian Journal of Plastic Surgery |
Clinical data| Données cliniques |
This single-center observational study was performed to investigate the presence of SARS-CoV-2 virus in wounds of COVID-19
positive patients. Preoperative, intraoperative, or postoperative specimens were collected and analyzed with real-time reverse transcriptase polymerase chain reaction (rRT-PCR) to know the presence of the virus. A total of eight patients were included in this
study. Eleven samples were collected (seven wound swabs, two peritoneal fluids, and two tissue specimens) and analyzed. None of the samples from the wound tested positive for the virus while they were tested positive for nasal swab taken simultaneously or
within 3 days prior. |
|
Gallichotte, EmilyN, Quicke, et al |
medRxiv |
Epidemiology| Épidémiologie Transmission Surveillance |
Assessed the prevalence and incidence of SARS-CoV-2 among long term care facilities (LTCF) workers, determine the extent
of asymptomatic SARS-CoV-2 infection, and provide information on the genomic epidemiology of the virus within these unique care settings. Collected nasopharyngeal swabs from workers for 8-11 weeks at six Colorado LTCFs, determined the presence and level of
viral RNA and infectious virus within these samples, and sequenced 54 nearly complete genomes. Our data reveal a strikingly high degree of asymptomatic/mildly symptomatic infection, a strong correlation between viral RNA and infectious virus, prolonged infections
and persistent RNA in a subset of individuals, and declining incidence over time. Our data suggest that asymptomatic SARS-CoV-2 infected individuals contribute to virus persistence and transmission within the workplace, due to high levels of virus. Genetic
epidemiology revealed that SARS-CoV-2 likely spreads between staff within an LTCF. |
|
|
Lupus anticoagulant and mortality in patients hospitalized for COVID-19 |
Gazzaruso, C, Mariani, et al |
J Thromb Thrombolysis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of our study was to investigate the association between lupus anticoagulant and mortality in a large group
of 192 consecutive patients hospitalized for COVID-19 in Italy. Our study did not show any association of lupus anticoagulant with mortality and with need for mechanical ventilation in survivors. The role of obesity, low SaO2 and elevated troponin levels as
predictors of a worse prognosis in patients hospitalized for COVID-19 was confirmed. |
|
Estimation and demographic analysis of COVID-19 infections with respect to weather
factors in Europe |
Gharoie Ahangar, R, Pavur, et al |
Journal of Business Analytics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The main objective of this study is to investigate the relationship between COVID-19 and the weather factors of the
most populated and industrialised countries in Europe (Spain, France, Italy, Germany, and the United Kingdom) and propose the best mathematical model to forecast the daily number of COVID-19 cases. The results reveal a statistically significant negative relationship
between the number of COVID-19 infections and weather factors of temperature & absolute humidity. |
|
Gianquintieri, L, Brovelli, et al |
ISPRS International Journal of Geo-Information |
Epidemiology| Épidémiologie |
The aim of this study was to identify the beginning of anomalous trends (change in the data morphology) in emergency
calls and EMS ambulances dispatches and reconstruct COVID-19 spatiotemporal evolution on the territory of Lombardy region. Both emergency calls and age- and gender-weighted ambulance dispatches resulted strongly correlated to COVID-19 casualties on a provincial
level, and the identified local starting days anticipated the official diagnoses and casualties, thus demonstrating how these parameters could be effectively used as early indicators for the spatiotemporal evolution of the epidemic on a certain territory. |
|
|
Gjerstad, CL, Bøe, et al |
Frontiers in Psychology |
Mental Health |
|
Understanding the psychological impact of the pandemic on HCWs is important in planning for future outbreaks of emerging
infectious diseases. In the current study, we look to findings from a highly relevant subsection of the trauma field, the military domain to inform factors associated with long-term posttraumatic stress symptoms (PTSS) in HCW working during the pandemic.
Our model accounted for 50% of the variance in PTSS, F(1503,11) = 139.00, p < 0.001. Age, relationship and employment status, preparedness, working environment, social support after deployment, barriers to disclose, recognition, and loneliness were all significantly
associated with PTSS on average 30 years after deployment. The most important risk factors of long-term PTSS were personal barriers to disclose one’s experiences and current unemployment. |
|
|
Glaeser, EL, Gorback, et al |
Journal of Urban Economics |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
Using zip code data across five U.S. cities, we estimate that total cases per capita decrease by 19% for every ten
percentage point fall in mobility. We find substantial spatial and temporal heterogeneity; east coast cities have stronger effects, with the largest for NYC in the pandemic’s early stages. |
|
|
Lockdown as an Intervention Measure to Mitigate the Spread of COVID-19: a modeling
study |
Góis, AN, Laureano, et al |
Revista da Sociedade Brasileira de Medicina Tropical |
Modelling/ prediction| Modélisation/prédiction Transmission Infection Prevention and
Control/ Prévention et contrôle des infections (IPAC/PCI) |
This work aims to develop a biomathematical transmission model of COVID-19, in the State of Sergipe, Brazil. We established
that lockdown is the intervention with the highest ability to mitigate the spread of the virus among the population. |
|
Laboratory Predictors for COVID-19 ICU Admissions in a Caribbean Territory |
Gopaul, Chavin, Ventour, et al |
Research Square prepub |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Identification of symptoms associated with COVID-19 cases that require intensive care unit (ICU) attention was the
goal of this study. The findings indicate that neutrophil, AST, LDH and CRP are suitable predictors of COVID-19 patients that should receive ICU care |
|
Gorini, A, Fiabane, et al |
Archives of Psychiatric Nursing |
Mental Health |
|
A multicentre cross-sectional study was conducted to assess perceived risk and fear of contagion, as well as mental
health outcomes among 650 Italian healthcare workers during the COVID-19 outbreak. A relevant proportion of the sample reported symptoms of anxiety, depression, and distress. Female sex, nursing profession, fear of being infected, as well as the time of exposure
to the COVID-19 spread and the fact of directly attending infected patients were the main risk factors for developing mental health disturbances. |
|
|
The mental health of staff working in intensive care
during COVID-19 |
Greenberg, Neil, Weston, et al |
medRxiv |
Mental Health |
|
Identified the rates of probable mental health disorder in ICU and anaesthetic staff in six English hospitals during
June and July 2020. 709 participants completed the surveys comprising 291 (41%) doctors, 344 (48.5%) nurses, and 74 (10.4%) other healthcare staff. Over half (58.8%) reported good wellbeing, however 45.4% met the threshold for probable clinical significance
on at least one of the following measures: severe depression (6.3%), PTSD (39.5%), severe anxiety (11.3%) or problem drinking (7.2%). 13.4% of respondents reported frequent thoughts of being better off dead, or of hurting themselves in the past two weeks.
We found that doctors consistently reported better mental health than nurses. |
|
Greene, Talya, Harju-Seppänen, et al |
medRxiv |
Mental Health |
|
Identified demographic, work-related and other predictors for clinically significant PTSD, depression, and anxiety
during the COVID-19 pandemic in UK frontline health and social care workers (HSCWs), and to compare rates of distress across different groups of HCSWs working in different roles and settings. Nearly 58% of respondents met the threshold for clinically significant
PTSD, anxiety or depression, and symptom levels were high across occupational groups and settings. Logistic regression analyses found that participants who were concerned about infecting others, who felt they could not talk with their managers, who reported
feeling stigmatised and who had not had reliable access to personal protective equipment (PPE) were more likely to meet criteria for a clinically significant mental disorder. Being redeployed during the pandemic, and having had COVID were associated with higher
odds for PTSD. Higher household income was associated with reduced odds for a mental disorder. |
|
|
Evaluation
of Patients Diagnosed with COVID-19 in Terms of Risk Factors |
Günal, Ö, Türe, et al |
Mikrobiyoloji bulteni |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Investigated the demographic characteristics and risk factors of patients with the diagnosis of COVID-19. A total of
100 patients (53 female and 47 male) were included in our study. The mean age of the patients was 54.42 (Age range= 20-90). When the risk factors for catching the disease were evaluated; it was determined that there was at least one risk factor in 46 patients;
30 patients had close contact with the COVID-19 patient in the social environment and 16 patients had a travel history outside the city in the last 14 days. The most common symptoms in our patients were; cough (93%), fever (42%), dyspnea (22%), weakness (8%),
sore throat (7%), diarrhea (6%), headache (5%) and sputum (2%). The most common comorbid conditions in our patients were detected as hypertension (42%), diabetes mellitus (DM) (21%), congestive heart failure (10%), allergic asthma (7%), chronic obstructive
pulmonary disease (6%), rheumatoid arthritis (3%), coronary artery disease (2%), solid organ tumour (2%), depression (1%) and epilepsy (1%). The mean age of our 15 patients who were monitored in intensive care unit was 65 y, the mean age of 85 patients followed
in the service was 52.55. When these two groups were compared in terms of comorbid diseases, the presence of DM was 40% higher in intensive care patients. In addition, the majority 11 patients (73%) of the patients hospitalized in the intensive care unit were
male. When smoking was evaluated as a risk factor for serious illness, 26% in intensive care unit had a smoking history, while none of the patients who have died due to COVID-19 had a smoking history. These findings suggested to us that smoking does not increase
the severity of COVID-19 disease. |
|
Influence of the COVID-19 Pandemic on Quality of Life of Patients with Parkinson's
Disease |
Guo, D, Han, et al |
Parkinson's Disease |
Public Health response| Interventions de santé publique |
This study investigated the influence of lockdown during the 2019 coronavirus disease (COVID-19) pandemic on the quality
of life of patients with Parkinson's disease (PD). a questionnaire survey involving 113 patients with PD from Xihu District, Hangzhou, Zhejiang. During the epidemic prevention and control period (February 1 to March 31, 2020), patients enrolled were asked
to fill out questionnaires, including the "COVID-19 Questionnaire for PD Patients during the Period of Epidemic Prevention and Control"and "39-item Parkinson's Disease Questionnaire (PDQ-39)."During the phase of gradual release of epidemic prevention and control
(April 1 to April 30, 2020), all patients were followed up again, and PDQ-39 questionnaires were completed. Results. The quality of life for patients during the period of epidemic prevention and control was worse than that after epidemic prevention and control
(P < 0.001). The biggest problem that they faced was that they could not receive their doctor's advice or guidance regularly. The quality of life of patients who had difficulty getting doctors' guidance or those who changed their routine medication due to
lockdown was even worse. Telemedicine was quite effective and efficient for patients to get doctors' guidance during lockdown. |
|
Combined interventions for severe novel coronavirus disease (Covid-19): Experience from
350 patients |
Guo, T, Shen, et al |
Infection and Drug Resistance |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
In this retrospective, multicenter study, the medical records of COVID-19 patients in Hunan, from January 21, 2020
to February 19, 2020 were reviewed in order to summarize the clinical features and effective therapy of severe COVID-19 patients. Overall, the rate of severe cases and mortality of COVID-19 in Hunan are lower than those in Wuhan. In addition to antivirals
and oxygen support, timely interventions including corticosteroids, immunoglobulin, and antibiotics, contribute to improving the prognosis of severe COVID-19 patients. |
|
Gupta, A, Anjum, et al |
Applied Soft Computing Journal |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper, an integrated stacked deep convolution network InstaCovNet-19 is proposed. The proposed model detects
COVID-19 and pneumonia by identifying the abnormalities caused by such diseases in Chest X-ray images of the person infected. The proposed model achieves an accuracy of 99.08% on 3 class (COVID-19, Pneumonia, Normal) classification while achieving an accuracy
of 99.53% on 2 class (COVID, NON-COVID) classification. The proposed model achieves an average recall, F1 score, and precision of 99%, 99%, and 99%, respectively on ternary classification, while achieving a 100% precision and a recall of 99% on the binary
class., while achieving a 100% precision and a recall of 99% on the COVID class. InstaCovNet-19’s ability to detect COVID-19 without any human intervention at an economical cost with high accuracy can benefit humankind greatly in this age of Quarantine. |
|
|
In Utero Vertical Transmission of Coronavirus Disease 2019 in a Severely Ill 29-week
Preterm Infant |
Gupta, AG, Malhotra, et al |
AJP Reports |
Transmission Clinical data| Données cliniques |
We present a case of likely intrauterine transmission of COVID-19 infection in a critically ill premature infant born
to a COVID-19 infected mother and describing her clinical course thus far. The clinical presentation in the infant is consistent with COVID-19 infection described so far in literature along with positive PCR, and positive COVID-19 serology: immunoglobulin
G, immunoglobulin M, and immunoglobulin A. |
|
Design of a multi-epitope peptide vaccine against SARS-CoV-2 based on immunoinformatics
data |
Habibi, SA, Azizan, et al |
Journal of Mazandaran University of Medical Sciences |
Vaccine Research| Recherche sur les vaccins |
This study aimed at designing a multi-epitope vaccine combining several T-cell and B-cell epitopes of the SARS-CoV-2.
Based on the immunoinformatics results obtained, it seems that different epitopes from SARS-CoV-2 structural proteins have high ability to stimulate humoral and cellular immune responses, so the multi-epitope vaccine designed with these epitopes, can help
to accelerate the production of effective vaccines against COVID-19. |
|
Long-Term Modeling of SARS-CoV-2 Infection of In Vitro Cultured Polarized Human Airway
Epithelium |
Hao, S, Ning, et al |
mBio |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
The polarized human airway epithelium (HAE) cultured at an airway-liquid interface (HAE-ALI) is an in vitro model mimicking
the in vivo human mucociliary airway epithelium and supports the replication of SARS-CoV-2. Prior studies characterized only short-period SARS-CoV-2 infection in HAE. In this study, continuously monitoring the SARS-CoV-2 infection in HAE-ALI cultures for a
long period of up to 51 days revealed that SARS-CoV-2 infection was long lasting with recurrent replication peaks appearing between an interval of approximately 7 to 10 days. Importantly, we identified that SARS-CoV-2 productive infection of HAE requires a
high viral load of >2.5 × 105 virions per cm2 of epithelium. |
|
Hasan, Md Kamrul, Kamruzzaman, et al |
Research Square prepub |
Therapeutics| Thérapeutique |
In this study, we have screened a library of compounds, containing approved RdRP inhibitor drugs in use to treat other
viruses (Favipiravir, Sofosbuvir, Ribavirin, Lopinavir, Tenofovir, Ritonavir, Galidesivir and Remdesivir) and their structural homologues, in order to identify potential inhibitors of SARS-Cov-2 RdRP. Extensive screening showed that five structural analogues
have notable inhibitory effects against RdRP of SARS-Cov-2. |
|
|
Hasan, SW, Ibrahim, et al |
Science of the Total Environment |
Epidemiology| Épidémiologie Surveillance |
This study reports SARS-CoV-2 viral load in wastewater influents and treated effluents of 11 wastewater treatment plants
(WWTPs), as well as untreated wastewater from 38 various locations, in the United Arab Emirates (UAE) in May and June 2020. Results showed that the viral load in wastewater influents from these WWTPs ranged from 7.50E+02 to over 3.40E+04 viral gene copies/L
with some plants having no detectable viral RNA by RT-qPCR. The virus was also detected in 85% of untreated wastewater samples taken from different locations across the country, with viral loads in positive samples ranging between 2.86E+02 and over 2.90E+04
gene copies/L. It was also observed that the precautionary measures implemented by the UAE government correlated with a drop in the measured viral load in wastewater samples, which were in line with the reduction of COVID-19 cases reported in the population.
Importantly, none of the 11 WWTPs' effluents tested positive during the entire sampling period, indicating that the treatment technologies used in the UAE are efficient in degrading SARS-CoV-2, and confirming the safety of treated re-used water in the country. |
|
|
Variability of Accessory Proteins Rules the SARS-CoV-2
Pathogenicity |
Hassan, Sk Sarif, Pal Choudhury, et al |
bioRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
This study suggests that the wide variations of accessory proteins seem to govern the pathogenicity of SARS-CoV-2.
SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 with putative functions to manipulate host immune mechanisms such as interferons, immune signaling receptor NLRP3 (NOD-, LRR-, and pyrin domain-containing 3) inflammasome, inflammatory
cytokines such as interleukin β (IL-1β) are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins of all complete proteomes (available as of October 26, 2020, in the National Center for Biotechnology Information depository)
of SARS-CoV-2, were observed across six continents. Across all continents, the decreasing order of percentage of unique variations in the accessory proteins was found to be ORF3a>ORF8>ORF7a>ORF6>ORF10>ORF7b. The highest and lowest unique variations of ORF3a
were observed in South America and Oceania, respectively. |
|
Dynamics of SARS-CoV-2 infection model with two modes of transmission and immune response |
Hattaf, K, Yousfi, et al |
Mathematical biosciences and engineering : MBE |
Clinical data| Données cliniques Immunology | Immunologie |
In this paper, we propose a new within-host model which describes the interactions between SARS-CoV-2, host pulmonary
epithelial cells and cytotoxic T lymphocyte (CTL) cells. Furthermore, the proposed model takes into account the lytic and nonlytic immune responses and also incorporates both modes of transmission that are the virus-to-cell infection through extracellular
environment and the cell-to-cell transmission via virological synapses. |
|
Heggestad, JacobT, Kinnamon, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Report on a microfluidic, multiplexed POC test that can profile the antibody response against multiple SARS-CoV-2 antigens
- Spike S1 (S1), Nucleocapsid (N), and the receptor binding domain (RBD) - simultaneously from a 60 microliter drop of blood, plasma, or serum. We assessed the levels of anti-SARS-CoV-2 antibodies in plasma samples from 19 individuals (at multiple time points)
with COVID-19 that required admission to the intensive care unit and from 10 healthy individuals. This POC assay shows good concordance with a live virus microneutralization assay, achieved high sensitivity (100%) and specificity (100%), and successfully tracked
the longitudinal evolution of the antibody response in infected individuals. We also demonstrated that we can detect a chemokine, IP-10, on the same chip, which may provide prognostic insight into patient outcomes. Because our test requires minimal user intervention
and is read by a handheld detector, it can be globally deployed in the fight against COVID-19 by democratizing access to laboratory quality tests. |
|
|
Heo, J, Park, et al |
J Med Internet Res |
Healthcare Response | Réponse des soins de santé |
This study aims to assess the usability of a novel platform used in the military hospitals in Korea to gather data
and deploy patient selection solutions for COVID-19. The platform introduced in this study enables evidence-based patient selection in an effortless and timely manner, which is critical in the military. With a well-designed user experience and an accurate
prediction model, this platform may help save lives and contain the spread of the novel virus, COVID-19. |
|
|
Hirten, RobertP, Danieletto, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Performed an evaluation of heart rate variability (HRV) collected by wearable devices, to identify and predict Coronavirus
disease 2019 (COVID-19) and its related symptoms. Using a mixed-effect COSINOR model the mean amplitude of the circadian pattern of the standard deviation of the interbeat interval of normal sinus beats (SDNN), a HRV metric, differed between subjects with
and without COVID-19. The mean amplitude of this circadian pattern differed between individuals during the 7 days before and the 7 days after a COVID-19 diagnosis compared to this metric during uninfected time periods. Significant changes in the mean MESOR
and amplitude of the circadian pattern of the SDNN was observed between the first day of reporting a COVID-19 related symptom compared to all other symptom free days. Prior to the diagnosis of COVID-19 by nasal PCR, significant changes in HRV were observed
demonstrating its predictive ability to identify COVID-19 infection. |
|
|
Hong, KS, Jang, et al |
Infection and Chemotherapy |
Therapeutics| Thérapeutique |
We observed and analyzed the clinical efficacy of the most used hydroxychloroquine (HCQ) for 30 days. In this study,
administration of HCQ <5 days from diagnosis (odds ratio: 0.111, 95% confidence interval: 0.034 - 0.367, P = 0.001) was the only protective factor for prolonging of viral shedding in COVID-19 patients. Early administration of HCQ significantly ameliorates
inflammatory cytokine secretion by eradicating COVID-19, at discharge. Our findings suggest that patients confirmed of COVID-19 infection should be administrated HCQ as soon as possible. |
|
|
Hornick, A, Tashtish, et al |
Pathogens and Immunity |
Clinical data| Données cliniques |
Between March 12 and April 19, 2020, 282 individuals with confirmed COVID-19 and red cell distribution width (RDW)
available within 7 days prior to COVID-19 confirmation were evaluated. Individuals were grouped by quartiles of RDW. Association between quartiles of RDW and mortality was assessed using the Kaplan-Meier method and statistical significance was assessed using
the log-rank test. The association between RDW and all-cause mortality was further assessed using a Cox propor-tional hazards model. Plasma cytokine levels in uninfected ambulatory adults without cardiovascular disease (n=38) were measured and bivariate Spearman
correlations and principle components analysis were used to identify relationships between cytokine concentrations with RDW. After adjusting for age, sex, race, cardiovascular disease, and hemoglobin, there was an association between RDW and mortality (Quartile
4 vs Quartile 1: HR 4.04 1.08-15.07]), with each 1% increment in RDW associated with a 39% increased rate of mortality (HR 1.39 1.21-1.59]). Remote RDW was also associated with mortality after COVID-19 infection. Among uninfected ambulatory adults without
cardiovascular disease, RDW was associated with elevated pro-inflam-matory cytokines (TNF-α, IL8, IL6, IL1b), but not regulatory cytokines (TGFb). |
|
|
Hu, X, Hu, et al |
Therapeutic Advances in Respiratory Disease |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To investigate clinical characteristics and identify risk factors for severity of coronavirus disease 2019 (COVID-19)
pneumonia outside of Wuhan, China. We included 213 patients with confirmed COVID-19 who had been discharged or died by 15 March 2020. We retrospectively collected epidemiological, clinical, laboratory, computed tomography imaging and outcome data. Most clinical
characteristics of this study were similar to those from studies in Wuhan, but there were lower mortality rate and milder severity. The median time from onset of symptoms to confirmation and hospitalization was 4 and 5 days, respectively. The median virus
clearance and shedding times were 10 and 15 days, respectively. Independent risk factors associated with the severe/critical group were dyspnea odds ratio (OR) = 19.48], ALT (OR = 6.02) and albumin (OR = 3.36). Independent risk factors associated with the
ICU group were dyspnea (OR = 8.88), COPD (OR = 31.80), D-dimer (OR = 8.37), ALT (OR = 28.76) and LDH (OR = 9.95) (p < 0.05). |
|
|
Huang, J, Kwan, et al |
ISPRS International Journal of Geo-Information |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study explores the relationship between the built environment and COVID-19 risk using the confirmed cases data
collected in Hong Kong. The results indicate that COVID-19 risk tends to be concentrated in particular areas of Hong Kong. Using the incidence rate as an indicator to assess COVID-19 risk may underestimate the risk of COVID-19 transmission in some suburban
areas. The GPR and GWPR models suggest a close and spatially heterogeneous relationship between the selected built-environment variables and the risk of COVID-19 transmission. |
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Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2
infection |
Huang, KY, Lin, et al |
EMBO Mol Med |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Authors demonstrated that ACE2-Fc could specifically abrogate virus replication by blocking the entry of SARS-CoV-2
spike-expressing pseudotyped virus into both ACE2-expressing lung cells and lung organoids. The preservation of peptidase activity also enables ACE2-Fc to reduce the angiotensin II-mediated cytokine cascade. |
|
Hüfner, A, Kiefl, et al |
Med Klin Intensivmed Notfmed |
Healthcare Response | Réponse des soins de santé |
The goal was to identify patients in the emergency department, who are at risk for COVID-19 disease, early by using
a score, so that they could be isolated pre-emptively. The score, which is easy to obtain during the initial assessment, supports the assessment of the pretest probability for a COVID-19 infection as part of the risk stratification and can influence the treatment
pathway in terms of pre-emptive isolation, PCR testing and other treatment options at an early stage. |
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Huh, K, Lee, et al |
Diabetes research and clinical practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Aims: This study aimed to assess whether body mass index (BMI), fasting plasma glucose (FPG) levels, blood pressure
(BP), and kidney function were associated with the risk of severe disease or death in patients with COVID-19. Methods: Data on candidate risk factors were extracted from patients’ last checkup records. The primary outcome was death or severe COVID-19, defined
as requiring supplementary oxygen or higher ventilatory support. Results: A BMI of 25.0–29.9 was associated with the outcome among women and patients aged 50–69 years. An FPG ≥ 126 mg/dL was associated with poor outcomes in women but not in men. Similarly,
estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 was a risk factor in women and patients aged < 70 years. |
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Describing the COVID-19 outbreak during the lockdown: fitting modified SIR
models to data |
Ianni, A, Rossi, et al |
European Physical Journal Plus |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this paper, we analyse the COVID-19 outbreak data with simple modifications of the SIR compartmental model, in order
to understand the time evolution of the cases in Italy and Germany, during the first half of 2020. Even if the complexity of the pandemic cannot be easily described, we show that our models are suitable for understanding the data during the application of
the social distancing and the lockdown. We compare and contrast different modifications of the SIR model showing the strengths and the weaknesses of each approach. Finally, we discuss the reliability of the model predictions for estimating the near- and far-future
evolution of the outbreak. © 2020, Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature. |
|
Inada-Kim, Matthew, Chmiel, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Analyzed COVID-19 patients conveyed by ambulance to hospital to investigate how oxygen saturation and measurements
of other vital signs correlate to patient outcomes to ascertain if clinical deterioration can be predicted with simple community physiological monitoring. Identified 1,080 adults with a COVID-19 diagnosis who were conveyed by ambulance to hospital between
March 1st and July 31st and whose diagnosis was clinically confirmed at hospital discharge. Vital signs measured by ambulance staff at first point of contact in the community correlated with patient short-term mortality or ICU admission. Oxygen saturations
were the most predictive of mortality or ICU admission (AUROC 0.772), followed by the NEWS2 score (AUROC 0.715), patient age (AUROC 0.690), and respiration rate (AUROC 0.662). Combining age with the NEWS2 score (AUROC 0.771) or the measured oxygen saturation
(AUROC 0.820) increased the predictive ability but did not reach significance. We found that even small deflections in oxygen saturations of 1-2% below 96% confer an increased mortality risk in those with confirmed COVID at their initial community assessments. |
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Iob, E, Frank, et al |
JAMA network open |
Mental Health |
|
The objective of this study was to examine levels of severity of depressive symptoms over time among individuals with
high risk in the UK during the COVID-19 pandemic. In this cohort study of UK adults participating in the COVID-19 Social Study, people with psychosocial and health-related risk factors, as well as those with low SEP, were at the most risk of experiencing moderate
or severe depressive symptoms during the COVID-19 pandemic. |
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Tailoring time series models for forecasting coronavirus spread: Case studies of
187 countries |
Ismail, L, Materwala, et al |
Computational and Structural Biotechnology Journal |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We analyze and compare the performance of the studied time series models using a comprehensive COVID-19 dataset. We
develop the models under study and evaluate their performance considering 187 countries in the world using Johns Hopkins Covid-19 dataset. The infections data trends for all these countries is similar to an exponentially increasing curve in the beginning and
then follow a linear line after some point in time. |
|
Izquierdo, JL, Ancochea, et al |
Journal of medical Internet research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Our primary objectives are to describe the clinical characteristics and determine the factors that predict intensive
care unit (ICU) admission of patients with COVID-19. Determining these factors using a well-defined population can increase our understanding of the real-world epidemiology of the disease. Our results show that a combination of easily obtainable clinical variables
(age, fever, and tachypnea with or without respiratory crackles) predicts whether patients with COVID-19 will require ICU admission. |
|
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Ambient temperature change Vs confirmed cases of COVID-19: A machine learning
model |
Jamshidnezhad, Amir, Hosseini, et al |
Research Square prepub |
Epidemiology| Épidémiologie Transmission |
This study analyzed the relationship between ambient air temperature and prevalence of viral infection. The results
showed that in the city of Ahvaz, despite the increase in temperature, the coefficient of determination R2 has been increasing. The propose that increased use of air conditioning positively impacts the frequency of positive cases. |
|
Ján, S, Tomáš, et al |
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti |
Clinical data| Données cliniques |
In this case report we present a 75-year-old patient with a localized gastric adenocarcinoma, currently treated by
perioperative chemotherapy regimen, who had an rT-PCR proven novel coronavirus SARS-CoV-2 infection. |
|
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Jean, SXY, Conceicao, et al |
Am J Infect Control |
Epidemiology| Épidémiologie Surveillance Healthcare Response | Réponse des soins de
santé |
We aimed to create a prototype staff surveillance system for the detection of acute respiratory infection (ARI) clusters
amongst our healthcare workers (HCWs) and describe its effectiveness. A prototypical surveillance system was built on existing electronic health record infrastructure. Over a 10-week period, we investigated 10 ARI clusters amongst 7 departments. One of the
ARI clusters was later determined to be related to COVID-19 infection. We demonstrate the feasibility of syndromic surveillance to detect ARI clusters during the COVID-19 outbreak. |
|
|
Computationally approached inhibition potential of Tinospora Cordifolia
towards COVID-19 targets |
Jena, Sushovan, Munusami, et al |
Research Square prepub |
Therapeutics| Thérapeutique |
Extract of Tinospora Cordifolia were investigated as potential drug candidates for COVID-19. The results of molecular
docking and ADME/T studies have revealed 6 constituents as potential drug candidates that can inhibit the binding of SARS-CoV-2 spike protein with the human receptor ACE2 protein. |
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Lived experiences of patients with COVID-19 infection: a phenomenology study |
Jesmi, AA, Mohammadzade-Tabrizi, et al |
Med Glas (Zenica) |
Mental Health |
|
We describe experiences of patients with COVID-19 infection. 14 patients with COVID-19 were selected (nine women and
five men) aged 20-60 years. Data were collected via in-depth interviews with open questions and through observation. Mental strains were the most important issues in the patients with COVID-19, which were interwoven with concerning physical manifestations.
Most of the participants used self-medication and spiritual resources to cope with the disease. |
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Digital PCR is a sensitive new technique for SARS-CoV-2 detection in clinical applications |
Jiang, Y, Wang, et al |
Clin Chim Acta |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In this study the feasibility of using a new digital PCR-based detection assay for clinical COVID-19 diagnosis was
investigated by comparing its performance with that of RT-PCR. Clinical patient samples and samples obtained from potentially contaminated environments were analyzed. The study included 10 patients with confirmed COVID-19 diagnoses. In analyses of environmentally
derived samples, the positivity rate of air samples was higher than that of surface samples, probably due to differences in virus concentrations. Digital PCR detected SARS-CoV-2 in several samples that had previously been deemed negative, including 3 patient-derived
samples and 5 environmentally derived samples. In this study digital PCR exhibited higher sensitivity than conventional RT-PCR, suggesting that it may be a useful new method for clinical SARS-CoV-2 detection. |
|
Risk factors for Coronavirus disease 2019 pneumonia after admission outside Wuhan,
China |
Jie, LS, Yu, et al |
Medicine (Baltimore) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Explored the risk factors for condition changes in COVID-19 pneumonia patients after admission. The patients diagnosed
with COVID-19 pneumonia at 2 medical centers in Hunan Province were studied, and those whose conditions changed after admission were compared. Patients with condition changes after admission were older and had more blood cell abnormalities and impaired organ
function (decreased albumin, elevated D-dimer) than normal patients. We found that age, neutrophil ratio, D-dimer, chest Computed tomograpgy (CT) changes, and glucocorticoid use were risk factors for COVID-19 pneumonia after admission. |
|
Jin, DanielK, Nesbitt, et al |
medRxiv |
Epidemiology| Épidémiologie Surveillance Diagnostics / Pathogen detection| Diagnostics
/ Détection d'agents pathogènes |
Reports the results of a rapid, point-in-time 1,000-person cohort study using serial blood donors in the New York City
metropolitan area (NYC) using multiple serological tests, including enzyme-linked immunosorbent assays (ELISAs) and high throughput serological assays (HTSAs). These were then tested and associated with assays for neutralizing Ab (NAb). Of the 1,000 NYC blood
donor samples in late June and early July 2020, 12.1% and 10.9% were seropositive using the Ortho Total Ig and the Abbott IgG HTSA assays, respectively. These serological assays correlated with neutralization activity specific to SARS-CoV-2. The data reported
herein suggest that seroconversion in this population occurred in approximately 1 in 8 blood donors from the beginning of the pandemic in NYC (considered March 1, 2020). These findings deviate with an earlier seroprevalence study in NYC showing 13.7% positivity.
Collectively however, these data demonstrate that a low number of individuals have serologic evidence of infection during this first wave and suggest that the notion of herd immunity at rates of ~60% or higher are not near. Furthermore, the data presented
herein show that the nature of the Ab-based immunity is not invariably associated with the development of NAb. While the blood donor population may not mimic precisely the NYC population as a whole, rapid assessment of seroprevalence in this cohort and serial
reassessment could aid public health decision making. |
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Acute cardiac injury in adult hospitalized COVID-19 patients in Zhuhai, China |
Jin, L, Tang, et al |
Cardiovascular Diagnosis and Therapy |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Methods: We retrospectively analyzed demographic, clinical, laboratory and cardiovascular imaging data of all consecutively
admitted adult COVID-19 patients in Zhuhai, China from January 17th, 2020 to February 18th, 2020. Results: Acute cardiac injury was found in 9 (9.7%) COVID-19 patients with median level of hypersensitive cardiac troponin I (hs-cTnI) to be 0.085 μg/L. Compared
with patients without cardiac injury, the median age of patients with cardiac injury was significantly older (65.0 vs. 44.0, P<0.05), hypertension was significantly more common, and the proportion of severe-critical cases were greater. |
|
Jin, R, Pettengill, et al |
Archives of Pathology & Laboratory Medicine |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Healthcare
Response | Réponse des soins de santé |
This study compared the analytical sensitivity of 3 commercial SARS-CoV-2 molecular assays, selected samples were studied
in parallel with Cobas SARS-CoV-2 test, NxTAG CoV Extended Panel, and ID NOW COVID-19 assays. The Ct values of cobas SARS-CoV-2-positive samples were evenly distributed throughout ranges of 13.32 to 39.50 (mean, 25.06) and 13.60 to 42.49 (mean, 26.45) for
ORF1 and E gene targets, respectively. NxTAG reliably detected only specimens with E gene Ct values lower than 33, and is estimated to detect 89.4% of positive specimens detected by cobas assay. ID NOW had performance variation independent of Ct value and
is estimated to detect 83.5% of cobas positives. |
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A case study of the first pregnant women with COVID-19 in Bukavu, Eastern
DR Congo |
Kajibwami Birindwa, Etienne, Mulinganya Mulumeoderhwa, et al |
Research Square prepub |
Clinical data| Données cliniques |
We report a case of a 25-year-old woman, gravida 3, para 2 (2 alive children), with a history of two caesarean deliveries,
who was infected by the SARS-Cov-2 during the last term of her pregnancy. |
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Kamaludin, K, Chinna, et al |
Heliyon |
Mental Health |
|
This study examined how university students in Malaysia coped with the psychological impact of the COVID-19 pandemic
and restrictions on movement (also known as MCO). A total of 983 students participated in a survey conducted online between April 20 and May 24, 2020. The results showed that the students used maladaptive coping strategies more than adaptive coping strategies
to deal with anxiety caused by the pandemic and the effect of restriction of movement. Seeking social support and acceptance coping strategies were significantly associated with the level of anxiety. The student's gender, age, ethnicity, level and type of
study, and living arrangement were associated with coping strategies. |
|
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New-onset postural orthostatic tachycardia syndrome following coronavirus disease
2019 infection |
Kanjwal, K, Jamal, et al |
Journal of Innovations in Cardiac Rhythm Management |
Long-Term Sequelae |
|
We report a case of new-onset postural orthostatic tachycardia syndrome in an otherwise healthy female patient following
COVID-19 infection. The patient presented with fatigue, orthostatic palpitations, dizziness, and presyncope. She underwent head-up tilt-table testing and the findings were suggestive of postural orthostatic tachycardia syndrome. |
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Deaths From COVID-19 in Rural, Micropolitan, and Metropolitan Areas: A County-Level Comparison |
Karim, SA, Chen, et al |
J Rural Health |
Epidemiology| Épidémiologie |
The objective of this study was to investigate the differences in death rates from COVID-19 between urban and rural
areas in the United States. The study focused on COVID-19-related mortality from February 10, 2020, to June 12, 2020. After controlling for county-level characteristics, the rate of COVID-19 deaths was 70.3% for rural counties and 53.4% for micropolitan counties,
both significantly lower than metropolitan counties during the study time period. |
|
Kataria, S, Tandon, et al |
eNeurologicalSci |
Clinical data| Données cliniques |
Authors present three patients with history of Multiple Sclerosis (MS) on DMTs presenting with worsening MS symptoms
likely pseudo exacerbation who were diagnosed with COVID-19. This review provides a base on the clinical characteristics, outcomes and the roles of DMTs in MS patients suffering from n-cov-2. |
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Kerr, B, Pharithi, et al |
IJC Heart and Vasculature |
Healthcare Response | Réponse des soins de santé |
We set out to address the physician and patient opinion of remote management of heart failure (HF) during COVID-19.
An observational report of the use of a Structured Telephonic assessment (STA) in stable outpatient HF patients. Physician grading of the STA was complemented by 100 randomly chosen patients to ascertain patient satisfaction and comment. Patient preference
for STA was noted in 66%. Convenience was the single most cited reason for this preference (83.3%). The STA was deemed satisfactory by clinicians in 67.6%. The two-leading reasons for clinician dissatisfaction were data gaps providing a barrier to titration
(55.6%) and need for clinical exam (18.9%). The annual review appointment visit subtype possessed the highest levels of satisfaction congruence amongst both clinicians and patients. |
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Khazaee-Pool, M, Shahrvsand, et al |
Journal of Mazandaran University of Medical Sciences |
Public Health response| Interventions de santé publique |
The aim of this study was to determine the predictors of COVID-19 preventive behaviors in Iranian population based
on the Health Belief Model. This study confirmed the predictive role of self-efficacy in COVID-19 preventive behaviors according to the Health Belief Model. Thus, providing ways to increase self-efficacy such as verbal persuasion, increasing awareness about
people abilities, and providing them with suitable models could promote preventive behaviors toward COVID-19. |
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|
Khosronejad, Ali, Santoni, et al |
arXiv |
Transmission Public health interventions*| Interventions de sant&eacute; publique |
This study conducted fluid dynamics simulations to elucidate the underlying physics of saliva particulate transport
during human cough with and without facial masks. Showed that during indoor coughing some saliva particulates could travel up to 0.48 m, 0.73 m, and 2.62 m for the cases with medical-grade, non-medical grade, and without facial masks, respectively. Thus,
in indoor environments either medical or non-medical grade facial masks can successfully limit the spreading of saliva particulates to others. Under outdoor conditions with a unidirectional mild breeze, however, leakage flow through the mask can cause saliva
particulates to be entrained into the energetic shear layers around the body and transported very fast at large distances by the turbulent flow, thus, limiting the effectiveness of facial masks. |
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Kim, JG, Lee, et al |
Osong Public Health and Research Perspectives |
Public Health Priorities| Priorités de santé publique |
This report describes the air evacuation of 80 Koreans from Iran to Korea on March 19th, 2020, with a direct transfer
of passengers between airplanes in Dubai. The passengers were potentially infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) so, strict precautions were taken for the duration of the flight, and the passengers were screened before embarking
from Dubai and disembarking at Incheon International Airport in Korea. Passengers with fever or symptoms of SARSCoV-2 were assessed by a quarantine doctor, and if they were suspected of being infected with SARSCoV-2, they were categorized as a “patient under
investigation (PUI)”. There was 1 passenger designated as a PUI before the departure from Dubai and another designated as a PUI upon arrival into Korea. The first PUI tested negative, but the second PUI tested positive for SARS-CoV-2. All those aboard the
flight (passengers, aircrew, and medical staff) were screened for SARS-CoV-2 upon arrival into Korea and completed a mandatory 14-day medical quarantine. There were no additional cases of infection. © 2020 Korea Disease Control and Prevention Agency. |
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|
Klamroth, Verena, Gemperle, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
This study provides an appraisal of experiences of Switzerland-based OTs and midwives regarding the provision of health
care at a distance (HCD) during the lockdown as it pertains to the COVID-19 pandemic in spring 2020. HCD during the early COVID-19 pandemic was generally perceived as positive by OTs and midwives. Most respondents desired support concerning reimbursement by
health insurance (70.8%), followed by law and data protection (60.4%). |
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Kowalski, J, Marchlewska, et al |
Psychiatry research |
Public Health response| Interventions de santé publique |
The objective was to explore what possible factors may modify relationships between conspiracy, paranoia-like beliefs,
and adherence to epidemiological guidelines; and to examine the prevalence of different coronavirus conspiracy beliefs. wo independent internet studies. Study 1 used a proportional quota sample that was representative of the population of Poles in terms of
gender and settlement size (n=507). Study 2 employed a convenience sample (n=840). Coronavirus conspiracy beliefs are negatively related to safety guidelines. Mixed results suggest that paranoia-like beliefs are related negatively to safety guidelines. Prevalence
of firmly held coronavirus conspiracy beliefs is rare. Nevertheless, certain percentage of participants agree with conspiracy beliefs at least partially. Coronavirus related anxiety, trust in media, and internal motivation to isolation moderate the relationship
between conspiracy beliefs and adherence to safety guidelines. Paranoia-like beliefs partially mediate between boredom and conspiracy beliefs. |
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|
Kraus, Aurora, Casadei, et al |
bioRxiv |
Coronavirology| Coronavirologie Animal model | Modèle animal |
This study used adult and larval zebrafish as models to investigate pathophysiological effects of SARS-CoV-2. Exposure
of larvae to SARS-CoV-2 Spike (S) receptor binding domain (RBD) recombinant protein was sufficient to elevate larval heart rate and treatment with captopril, an ACE inhibitor, reverted this effect. Intranasal administration of SARS-CoV-2 S RBD in adult zebrafish
recombinant protein caused severe olfactory and mild renal histopathology. Zebrafish intranasally treated with SARS-CoV-2 S RBD became hyposmic within minutes and completely anosmic by 1 day to a broad-spectrum of odorants including bile acids and food. Single
cell RNA-Seq of the adult zebrafish olfactory organ indicated widespread loss of expression of olfactory receptors as well as inflammatory responses in sustentacular, endothelial, and myeloid cell clusters. Exposure of wildtype zebrafish larvae to SARS-CoV-2
in water did not support active viral replication but caused a sustained inhibition of ace2 expression, triggered type 1 cytokine responses and inhibited type 2 cytokine responses. |
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Krechetova, LV, Vtorushina, et al |
Akusherstvo i Ginekologiya (Russian Federation) |
Epidemiology| Épidémiologie Immunology | Immunologie |
This study aimed to identify IgG antibodies to SARS-CoV-2 in healthcare professionals of the National Medical Research
Center for Obstetrics, Gynecology and Perinatology during the quarantine from April to June 2020. The study included 1589 healthcare workers: 1293 professionals of ‘green zone’ and 926 medical staff of ‘red zone’. IgG antibodies to SARS-CoV-2 were detected
in 141 healthcare workers (8.9%), controversial results were revealed in 2 professionals, and 1445 (90.9%) workers had no antibodies, including 46 (3.2%) people who had the clinical symptoms of acute respiratory viral disease (ARVI) and identified SARS-CoV-2
RNA. Among healthcare workers with antibodies, the clinical symptoms of ARVI were revealed in 129 (91.5%) workers, they were also detected SARS-CoV-2 RNA; 23 (17.8%) people had clinical symptoms of ARVI but SARS-CoV-2 RNA was not extracted; 12 (8,5%) workers
had neither clinical symptoms of ARVI nor detected SARS-CoV-2 RNA. |
|
|
Krome, S |
Pneumologie |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Abstract not available in English |
|
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Kubatova, N, Qureshi, et al |
Biomol NMR Assign |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study reports the near-complete NMR resonance assignment for the backbone chemical shifts of the non-structural
protein 10 (nsp10). Nsp10 is part of the viral replication-transcription complex (RTC). It aids in synthesizing and modifying the genomic and subgenomic RNAs. Via its interaction with nsp14, it ensures transcriptional fidelity of the RNA-dependent RNA polymerase,
and through its stimulation of the methyltransferase activity of nsp16, it aids in synthesizing the RNA cap structures which protect the viral RNAs from being recognized by the innate immune system. Both of these functions can be potentially targeted by drugs.
This data will aid in performing additional NMR-based characterizations, and provide a basis for the identification of possible small molecule ligands interfering with nsp10 exerting its essential role in viral replication. |
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Impact of COVID-19 Outbreak on the Emergency Presentation of Acute Appendicitis |
Kumaira Fonseca, M, Trindade, et al |
Am Surg |
Healthcare Response | Réponse des soins de santé |
The present study assesses the local impact of the coronavirus pandemic on the emergency presentation of acute appendicitis
in a Brazilian hospital. The number of appendectomies during the pandemic was 36, which represents a 56% reduction compared to the 82 patients operated during the same period in 2019. The average time of symptom onset to hospital arrival was significantly
higher in 2020 (40.6 vs. 28.2 hours, P = .02). The classification of appendicitis revealed a significant higher proportion of complicated cases than the previous year (33.3% vs. 15.2%, P = .04). The rate of postoperative complications and the average length
of stay were not statistically different between the groups. |
|
Kurian, SJ, Bhatti, et al |
Mayo Clinic proceedings |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We evaluate whether a digital surveillance model using Google Trends is feasible for obtaining accurate data on coronavirus
disease 2019 and whether accurate predictions can be made regarding new cases. This study documents the feasibility of syndromic surveillance of internet search terms to monitor new infectious diseases such as coronavirus disease 2019. |
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Kuzyukova, A, Odarushchenko, et al |
Psychiatry, Psychotherapy and Clinical Psychology |
Mental Health |
|
To study the characteristics of responding to a current stressful situation caused by the COVID-19 pandemic of various
contingents of the population, including medical workers who do not work directly with COVID-19 patients. 132 respondents were surveyed online. The questionnaire included biometric indicators, questions for evaluating the relevance to the COVID-19 pandemic,
and the Spielberger-Hanin scale. For statistical analysis, the Kruskal-Wallis test, the Mann-Whitney U test, and Pearson χ2 were used. Depending on the field of activity, all respondents were divided into 4 groups: Health professionals working in another field,
those receiving education, and people without permanent employment. The changes were recorded in the general sample, indicating the increase of the level of anxiety due to the current stressful situation. Statistically significant intergroup differences were
revealed (with significance level p≤0.05) in terms of constitutional and situational anxiety reflecting the current state of the individual: Respondents with a high level of personal anxiety were found more often in the groups of healthcare professionals and
those receiving education than among the other two groups; they also registered the increase of the level of situational anxiety to high rates, quantitatively most pronounced in the group of health workers (for the majority), qualitatively in those receiving
education, where 1/3 of the respondents recorded extremely high, clinically significant levels. Whereas in the other 2 groups there was an opposite tendency-to react with low levels of situational anxiety in a significant part of cases. |
|
|
Lahav, Y |
J Affect Disord |
Mental Health |
|
This study aimed to investigate these suppositions in the context of the ongoing shelling of Israel from the Israel-Gaza
border, which continues even amidst the COVID-19 crisis. Trauma survivors reported elevated psychiatric symptomatology related to COVID-19. Continuous traumatic stress was associated with symptomatology during COVID-19. Continuous traumatic stress moderated
the relations between PTSD and symptomatology. |
|
|
Lampl, BenediktMJ, Buczovsky, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We collected clinical and epidemiologic data in an almost complete cohort of SARS-CoV-2 positive individuals from Regensburg,
Germany, from March 2020 to May 2020. A broad range of symptoms and symptom duration was seen, some of them lasting several weeks. The case fatality rate was 2.1%. Asymptomatic cases may be underrepresented due to the nature of the study. |
|
|
Lapidus, Nathanael, Paireau, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Surveillance |
Seroprevalence results coupled with surveillance data were used to estimate the SARS-CoV-2 infection hospitalization
(IHR) and infection fatality ratios (IFR) in France. IHR and IFR were dramatically high in the very elderly (80-90 years: IHR: 30%, IFR: 11%), but also substantial in middle-aged adults (40-50 years: IHR: 1.2%, IFR: 0.05%). |
|
|
Lawal, O, Nwegbu, et al |
GeoJournal |
Public Health response| Interventions de santé publique |
This study investigate movement patterns during the national lockdown in Nigeria using mobile phone mobility data.
Place categories witnessed mobility reduction as high as 56%, 57%, 65%, 75%, 38% for retail and recreation (RtRc), Grocery and Pharmacy (GrPh), Park, and Transport Hubs (Trst) respectively. Most States recorded mobility uptrend towards workplace, retail and
recreational areas. Multiple correspondence analysis (MCA) identified two dimensions from the Space-time trends. The first dimension (D1) accounted for 66% of the variance. Examination of the Object Scores from the MCA showed that there are two classes–two
risk perception groups. |
|
|
Lee, Hye Kyung, Jung, et al |
bioRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study identifies candidate regulatory elements in the ACE2 locus in human primary airway cells and lung tissue.
Activating histone and promoter marks and Pol II loading characterize the intronic dACE2 and define novel candidate enhancers distal to the genuine ACE2 promoter and within additional introns. dACE2, and to a lesser extent ACE2, RNA levels increased in primary
bronchial cells treated with interferons and this induction was mitigated by Janus kinase (JAK) inhibitors that are used therapeutically in COVID-19 patients. This analyses provide insight into regulatory elements governing the ACE2 locus and highlight that
JAK inhibitors are suitable tools to suppress interferon-activated genetic programs in bronchial cells. |
|
|
Lemos, PA, Franken, et al |
Cardiovascular Diagnosis and Therapy |
Clinical data| Données cliniques |
A 60-year-old male with non-ST-elevation myocardial infarction and COVID-19 was treated with successful coronary implantation
of two stents in the obtuse marginal branch and one stent in the circumflex artery. The total duration of the procedure was 103 minutes and 22 seconds. |
|
|
Li, R, Liu, et al |
Hong Kong Journal of Emergency Medicine |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The objective of this observational study compare the performances of point-of-care lung ultrasound (LUS) and bedside
chest X-ray in assessing the condition of COVID-19 patients with acute respiratory distress syndrome (ARDS). All patients were given invasive mechanical ventilation; eight (19.0%) of them received venovenous extracorporeal membrane oxygenation support. LUS
has evident advantages in detecting lung consolidation, patchy shadows, and pleural thickening, and pleural line changes in particular. The receiver operating characteristic analysis indicated that the sensitivity, Youden index, and kappa value for detecting
COVID-19 patients with ARDS were higher for LUS than the chest X-ray. |
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|
Li, T, Zheng, et al |
Emerg Microbes Infect |
Vaccine Research| Recherche sur les vaccins |
Authors expressed and evaluated as potential candidates four versions of the spike (S) protein using an insect cell
expression system. Results suggest that the prefusion trimer-stabilized SARS-CoV-2 S-protein from insect cells may offer a potential candidate strategy for the development of a recombinant COVID-19 vaccine. |
|
|
Li, Y, Zhou, et al |
Emerg Microbes Infect |
Therapeutics| Thérapeutique |
Authors test the hypothesis that short-term, low-to-moderate-dose corticosteroids would benefit patients when used
in the early phase of excessive inflammation, namely, the therapeutic window. Among COVID-19 patients with marked radiologic progression, short-term, low-to-moderate-dose corticosteroids benefits patients with lactase dehydrogenase (LDH) levels of less than
two times the upper limit of normal (ULN), who may be in the early phase of excessive inflammation. |
|
|
Nodosome inhibition as a novel broad-spectrum antiviral
strategy against arboviruses and SARS-CoV-2 |
Limonta, Daniel, Dyna-Dagman, et al |
bioRxiv |
Therapeutics| Thérapeutique |
This work describes two small molecules with broad-spectrum antiviral activity. These drugs block formation of the
nodosome. A drug that targets NOD2 was shown to have potent broad-spectrum antiviral activity against other flaviviruses, alphaviruses and SARS-CoV-2, the causative agent of COVID-19. Another drug that inhibits the receptor-interacting serine/threonine-protein
kinase 2 (RIPK2) which functions downstream of NOD2, also decreased replication of these pathogenic RNA viruses. The broad-spectrum action of nodosome targeting drugs is mediated, at least in part, by enhancement of the interferon response. |
|
Lin, TC, Lee, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper, we describe a potential methodology, integration of image preprocess, Guided Grad-CAM, machine learning
and risk management based on chest radiography images, as one of workable alarm and analysis systems to support clinicians against COVID-19 outbreak threat. We leverage pre-trained CNN models as backbone with further transfer learning to analyze public open
datasets composed of 5851 chest radiography images for 4 classes classification, and 15478 images from COVIDx dataset for 3 classes classification, facilitated with steps of ROI and mask, and CNN layer visualization of guided grad-CAM to help CNN focused on
critical infection focus in qualitative perspective. In quantitative perspective of 4 classes classification result, accuracy, average sensitivity, average precision, and COVID19 sensitivity of single ResNet50 and our second bagging ensemble model are (77.2%/78.8%/81.9%/100%)
and (81.5%/81.4%,86.8%/100%) respectively. Ensemble way of several CNNs and other machine learning methods used here is to contribute about 4% accuracy improvement on top of best single CNN (ResNet50). In our 3 classes classification, those metrics of ensemble
model and benchmark are (93.1%/90.1%/89.7%/83%) and (90%/85.9%, 82.4%/77%). We conclude ensemble approach would facilitate weaker classifier more. Beside to accuracy-oriented analysis, a cost minimization approach is suggested here to provide clinicians options
of different risk consideration flexibility by trade off among different categories and performance rates. |
|
|
Ling, P, Luo, et al |
Journal of Diabetes |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We conducted this study to investigate the association of glycosylated hemoglobin (HbA1c) and the outcome of COVID‐19
and determine the optimal glucose level during the early stage of their hospitalization among patients with preexisting diabetes, in a cohort of laboratory‐confirmed COVID‐19 patients in China. Poor HbA1c levels prior to coronavirus disease 2019 (COVID‐19)
might not be associated with severity among patients with preexisting diabetes. Mean blood glucose seemed not to be associated with poor prognosis of COVID‐19. |
|
|
Liu, P, Zhang, et al |
Clinical Respiratory Journal |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This paper describes the layout and functioning of a typical Fangcang shelter hospital, Wuhan Dongxihu Fangcang shelter
Hospital, where the author has worked, the working mechanism, experience and effectiveness. WeChat platform with different groups was used for communication, ward round, test appointments and patient data communication. As a result, 442 mild or moderate COVID-19
patients in Hall C were successfully managed by a team of 40 doctors, with 246 (56%) patients were cured and discharged from the Fangcang shelter hospital while the remaining 196 (44%) patients were referred on to designated hospitals for further treatment. |
|
|
Liu, S, Yao, et al |
American Journal of Emergency Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The assessment of illness severity at admission can contribute to decreased mortality in patients with the coronavirus
disease (COVID-19). This study was conducted to evaluate the effectiveness of the Sequential Organ Failure Assessment (SOFA) and Quick Sequential Organ Failure Assessment (qSOFA) scoring systems at admission for the prediction of mortality risk in COVID-19
patients. The area under the ROC curve for SOFA in predicting mortality was 0.890 (95% CI: 0.826–0.955), which was higher than that of qSOFA (0.742, 95% CI 0.657–0.816). An optimal cutoff of ≥3 for SOFA had sensitivity, specificity, positive predictive value,
and negative predictive value of 90.00%, 83.18%, 50.00%, and 97.80%, respectively. |
|
|
Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19 |
Liu, Y, Lv, et al |
Cell Res |
Clinical data| Données cliniques Coronavirology| Coronavirologie Animal model | Modèle
animal |
In this study, we show that mucins are accumulated in the bronchoalveolar lavage fluid (BALF) of COVID-19 patients
and are upregulated in the lungs of severe respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected mice and macaques. We find that induction of either interferon (IFN)-β or IFN-γ upon SARS-CoV-2 infection results in activation of aryl hydrocarbon receptor
(AhR) signaling through an IDO-Kyn-dependent pathway, leading to transcriptional upregulation of the expression of mucins, both the secreted and membrane-bound, in alveolar epithelial cells. These findings potentially explain the silent hypoxia formation
in COVID-19 patients, and suggest a possible intervention strategy by targeting the AhR pathway. |
|
Liu, Y, Mattke, et al |
Preventive medicine |
Mental Health |
|
We used a nationally representative survey of 1094 American adults collected between March 19 and March 31, 2020 to
compare risk-reduction behaviors and mental distress in states with and without orders. Risk reduction behaviors included hand washing, wearing face mask and social distancing, and the mental distress was assessed by the four-item version of the Patient Health
Questionnaire (PHQ-4). Results show that the probability of adopting risk reduction behaviors increased between 8 (avoidance of people with high risk, 87% to 95%) and 27 (use of face mask, 18% to 45%) percentage points in the response period. Mental distress
increased by 1.0 point on the PHQ-4 score (from 2.4 to 3.5 point) in the first week and started to drop afterwards. In summary, stay-at-home orders were associated with a differential increase in risk-reduction behaviors. People's mental distress rose in the
first week under order and dropped afterwards. While in need for confirmation in longitudinal data, these results suggest that residents are responsive to orders. |
|
|
Liu, Zhuoming, VanBlargan, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
To define the immune-mediated mutational landscape in S protein, this study used a VSV-eGFP-SARS-CoV-2-S chimeric virus
and 19 neutralizing monoclonal antibodies (mAbs) against the receptor binding domain (RBD) to generate 48 escape mutants. These variants were mapped onto the RBD structure and evaluated for cross-resistance by convalescent human plasma. Although each mAb had
unique resistance profiles, many shared residues within an epitope, as several variants were resistant to multiple mAbs. Remarkably, identified mutants that escaped neutralization by convalescent human sera, suggesting that some humans induce a narrow repertoire
of neutralizing antibodies. |
|
|
Liu, ZZ, Wu, et al |
International Eye Science |
Healthcare Response | Réponse des soins de santé |
To analyze the demands, consultation patterns and contributing factors of the patients involved in the ophthalmic on-line
consultation during the COVID-19 epidemic to provide reference for the optimization of the ophthalmic online health care system. The number of repeated visits for the patients with diagnosed ophthalmopathy and ophthalmic surgery was higher than that for the
patients with new-onset discomfort; the number of repeated visits was lower for the patients with lens and anterior segment diseases, and was higher for the patients with ocular surface diseases. |
|
|
Lopez-Mendez, I, Aquino-Matus, et al |
Annals of Hepatology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of the study was to determine the prevalence of liver steatosis and fibrosis in patients with COVID-19 and
their association with clinical outcomes. Of 155 patients, 71.6% were male (n = 111), and 28.4% (n = 44) were obese. Abnormal LFT were present in 96.8% (n = 150), prevalence of steatosis was 42.6% (n = 66) and of significative liver fibrosis was 44.5% (n =
69). Liver fibrosis by FIB-4 was associated with risk of ICU admission (OR 1.74 95%CI 1.74–2.68; p = 0.023]) and mortality (OR 6.45 95%CI 2.01−20.83, p = 0.002]), no independent associations were found. |
|
|
Lovell-Read, Francesca, Funk, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission |
Use COVID-19 as a case-study to show how the risk of local outbreaks can be assessed when nonsymptomatic transmission
can occur. Construct a branching process model that includes nonsymptomatic transmission, and explore the effects of interventions targeting nonsymptomatic or symptomatic hosts when surveillance resources are limited. Specifically, we consider whether the
greatest reductions in local outbreak risks are achieved by increasing surveillance and control targeting nonsymptomatic or symptomatic cases, or a combination of both. Seeking to increase surveillance of symptomatic hosts alone is typically not the optimal
strategy for reducing outbreak risks. Adopting a strategy that combines an enhancement of surveillance of symptomatic cases with efforts to find and isolate nonsymptomatic hosts leads to the largest reduction in the probability that imported cases will initiate
a local outbreak. |
|
|
Disease progression in patients with COVID-19: a retrospective cohort study in China |
Luo, H, Liu, et al |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and
Lung Disease |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective study evaluates the clinical features of disease progression among patients with COVID-19 to help
early identification of patients at high risk. Of the 625 patients in Jiangsu, none died; 597 patients were asymptomatic or had mild or moderate disease on admission, of whom 36 (6%) experienced disease deterioration to become severe or critically ill. Disease
deterioration to severe or critically ill status was associated with age, pulmonary opacity score, lymphocyte count on admission and exposure to the pandemic centre in Wuhan. |
|
Lupia, T, Corcione, et al |
Parasitol Int |
Clinical data| Données cliniques |
This letter to the editor describes a case of a 66-year-old man was admitted to the hospital with an acute respiratory
distress syndrome due to SARS-CoV-2 infection, who was hospitalized and received a positive antigen test for Giardia spp. and a large amount of trophozoites and cysts of Giardia lamblia in the stool test. Based on these observations, the risk of reactivation
of latent parasite infection should be considered during SARS-CoV-2 infection, especially during the acute or recovery phase. |
|
|
Ma, Li, Zeng, et al |
Research Square prepub |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
A retrospective study was conducted at the Shanghai Public Health Clinical Center to investigate whether low molecular
weight heparin (LMWH) can reduce organ injury in patients with Covid-19 pneumonia. LMWH might be beneficial to improve renal function, CO2 discharge and microcirculation during the early phase of Covid-19 patients |
|
|
PMC7309423; Epidemic Trend of COVID-19 Transmission in India During Lockdown-1
Phase |
Mahajan, P, Kaushal, et al |
J Community Health |
Epidemiology| Épidémiologie |
This paper aims to assess the current epidemic trend of COVID-19/SARS-CoV-2 in India, the epidemic dynamics of COVID-19
cases in India in terms of Case Fatality Rate (CFR), Case Recovery Rate (CRR) and Mortality rate (MR) COVID-19 have been evaluated during Lockdown-1. As of April 14, the CFR per total cases in India is 3.32% and per closed cases is 23.27%. The CRR per total
cases in India is 11.00% and per closed cases is 76.72%, which indicates that the recovery rate of COVID-19 is more than the fatality rate in India. |
|
Mahil, SatveerK, Yates, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Investigated whether greater risk-mitigating behaviour in people with immune-mediated inflammatory diseases (IMIDs)
receiving targeted systemic therapies have fewer adverse COVID-19 outcomes compared to patients receiving no systemic treatments. Of 3,720 participants (2,869 psoriasis, 851 RMD) from 74 countries, 60.8% reported the most stringent risk-mitigating behaviour
(classified here under the umbrella term shielding). A greater proportion of those receiving targeted therapies (biologics and JAK inhibitors) reported shielding compared to those receiving no systemic therapy (adjusted odds ratio [OR] 1.63) and standard systemic
agents (OR 1.39). Shielding was associated with established risk factors for severe COVID-19 (male sex OR 1.14, obesity OR 1.38, comorbidity burden OR 1.43), a primary indication of RMD (OR 1.37) and a positive anxiety or depression screen (OR 1.57). Modest
differences in the proportion shielding were observed across nations. Therefore, greater risk-mitigating behaviour among people with IMIDs receiving targeted therapies may contribute to the reported lower risk of adverse COVID-19 outcomes. |
|
|
Plastic Drape and Copper Frame For Airway Management in the COVID-19 Era:
A Case Series |
Mainville, DarcyJ, Hou, et al |
Research Square prepub |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
The addition of a copper frame to a plastic drape over patients was an effective way to improve the safety and ease
of intubation in the COVID-19 pandemic. |
|
Antibody reactivity to SARS-CoV-2 is common in unexposed
adults and infants under 6 months |
Majdoubi, Abdelilah, Michalski, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Measured IgG against multiple SARS-CoV-2 antigens, SARS-CoV and other circulating coronavirus spike proteins using
a highly sensitive multiplex assay, and total SARS-CoV-2 spike-specific antibodies (IgG/M/A) using a commercial CLIA assay in 276 adults from the Vancouver area, Canada between May 17th and June 19th 2020. Reactivity threshold in unexposed individuals were
defined comparing to pre-pandemic sera and to sera from infants under 6 months of age. The seroprevalence from a SARS-CoV-2 exposure, adjusted for false-positive and false-negative test results, was 0.60% in our adult cohort. High antibody reactivity to circulating
endemic coronaviruses was observed in all adults and was about 10-fold lower in infants under 6 months. Consistent with a waning of maternal antibodies, reactivity in infants decreased more than 50-fold eight months later. SARS-CoV-2 Spike, RBD, NTD or nucleocapsid
antibody reactivity >100-fold above that of older infants was detected in the vast majority of unexposed adults and pre-pandemic sera. This antibody reactivity correlated with titers against circulating coronaviruses, but not with age, sex, or whether adults
were healthcare workers. |
|
Majidi, Hadi, Bani-Mostafavi, et al |
Research Square prepub |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study was conducted to investigate the Chest High Resolution Computed Tomography (HRCT) findings of patients infected
with the new Coronavirus 2019. The present study indicated that in addition to ground-glass opacity (GGO), peripheral distribution findings could be a vital diagnostic choice in COVID-19 patients. |
|
|
Manikyam, Hemanth Kumar |
Research Square prepub |
Therapeutics| Thérapeutique |
Spike (S) protein of the SARS-CoV-2 uses angiotensin-converting enzyme II (ACE2) and TRMPSS as a cell entry. Natural
compounds like Withanolide A, Columbin, Cucurbitacin E, Boswellic acid along with Cyclosporines, Vitamin E and N-Acetyl cysteine (NAC) were selected as ligands to study docking studies. |
|
|
The threat of COVID-19 and its influence on nursing staff burnout |
Manzano García, G, Ayala Calvo, et al |
J Adv Nurs |
Healthcare Response | Réponse des soins de santé |
This cross-sectional study evaluates whether the perceived threat of COVID‐19 moderates the influence of work resources
and demands on burnout. Work overload, material and human resources and social support at work were significant in explaining burnout. The perceived threat of COVID‐19 variable was also significant and presented the highest regression coefficient (β =. 392).
The perceived threat of COVID‐19 moderated the relationship between social support at work and burnout. |
|
Marinova, E, Dabov, et al |
Biotechnology and Biotechnological Equipment |
Public Health response| Interventions de santé publique |
The purpose of this report is to highlight the risk of ophthalmic complaints in the face mask-wearing, to discuss some
pathogenic mechanisms for their occurrence, and to offer therapy and ocular protection with a potential beneficial effect on the local resistance to viral invasion. A pilot study was designed to estimate the prevalence of ocular complaints in face mask-wearing
and their relation with mask type and the duration of usage. Of all the participants, 90.2% (n = 130) reported some kind of physical and social disturbance, 59.7% (n = 88) reported skin irritations, 82% (n = 118) shortness of breath with the mask, 10.4% (n = 15)
complained of a headache at the end of the day. 70.1% (n = 101) reported ocular symptoms, including burning, redness, tearing, foreign body sensation, itching, blurred vision, dry eye feeling and undefined eye discomfort. |
|
|
Marton, G, Vergani, et al |
Frontiers in Psychology |
Mental Health |
|
The study aimed to investigate the mental health and emotional reaction of physicians working during phase 1 of the
COVID-19 pandemic in Italy. The sample (n = 458) has a high level of psychological distress 21.26 (SD = 4.46), the emotional reaction was characterized by high level of fear for family members and cohabitants (M = 77.67, SD = 27.16) and patients (M = 67.16,
SD = 27.71). Perceived control, fear for patients, and for family members and cohabitants, feeling alone and anger all contribute to a decreased mental health in Italian physicians (R2 = 0.285, p < 0.001). |
|
|
MiR-98 regulates tmprss2 expression in human endothelial cells: Key implications
for covid-19 |
Matarese, A, Gambardella, et al |
Biomedicines |
Coronavirology| Coronavirologie |
This research focused on studying the microRNAs that specifically target TMPRSS2. Through a bioinformatic approach,
identified miR-98-5p as a suitable candidate. Mechanistically validated miR-98-5p as a regulator of TMPRSS2 transcription in two different human endothelial cell types, derived from the lung and from the umbilical vein. Taken together, the findings indicate
that TMPRSS2 represents a valid target in COVID-19 treatment, which may be achieved by specific non-coding-RNA approaches. |
|
Matusiak, Ł, Szepietowska, et al |
Advances in clinical and experimental medicine : official organ Wroclaw Medical University |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
The study was undertaken to assess the use of face masks among students during the COVID-19 pandemic, with focus on
similarities and differences between medical and non-medical students. Medical students showed significantly different attitudes and practices concerning the use of face masks. Medical students used face masks more commonly and for longer periods of time.
Moreover, they wore single-use masks more often and less frequently re-used them. Also, multiple use of single-use face masks and masks decontamination procedures were less common among medical students. |
|
|
McGregor, R, Whitcombe, et al |
PeerJ |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We established ELISA-based immunoassays using locally produced antigens when New Zealand went into a nationwide lockdown
and the supply chain of diagnostic reagents was a widely held domestic concern. The relationship between serum antibody binding measured by ELISA and neutralising capacity was investigated using a surrogate viral neutralisation test (sVNT). A pre-pandemic
sera panel (n = 113), including respiratory infections with symptom overlap with COVID-19, was used to establish assay specificity. Sera from PCR‑confirmed SARS-CoV-2 patients (n = 21), and PCR-negative patients with respiratory symptoms suggestive of COVID-19
(n = 82) that presented to the two largest hospitals in Auckland during the lockdown period were included. A two-step IgG ELISA based on the receptor binding domain (RBD) and spike protein was adapted to determine seropositivity, and neutralising antibodies
that block the RBD/ hACE‑2 interaction were quantified by sVNT. The calculated cut-off (>0.2) in the two-step ELISA maximised specificity by classifying all pre-pandemic samples as negative. Sera from all PCR-confirmed COVID-19 patients were classified as
seropositive by ELISA ≥7 days after symptom onset. There was 100% concordance between the two-step ELISA and the sVNT with all 7+ day sera from PCR‑confirmed COVID-19 patients also classified as positive with respect to neutralising antibodies. Of the symptomatic
PCR-negative cohort, one individual with notable travel history was classified as positive by two-step ELISA and sVNT, demonstrating the value of serology in detecting prior infection. |
|
|
COVID-19 Wastewater Epidemiology: A Model to Estimate
Infected Populations |
McMahan, Christopher Steven, Self, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission Surveillance |
Composite wastewater samples were collected from three sewersheds and tested for SARS-CoV-2 RNA. A Susceptible-Exposed-Infectious-Removed
(SEIR) model based on mass rate of SARS-CoV-2 RNA in the wastewater was developed to predict the number of infected individuals. Predictions were compared to confirmed cases identified by the South Carolina Department of Health and Environmental Control for
the same time period and geographic area. Model predictions for the relationship between mass rate of virus release to the sewersheds and numbers of infected individuals were validated based on estimated prevalence from individual testing. A simplified equation
to estimate the number of infected individuals fell within the 95% confidence limits of the model. The unreported rate for COVID-19 estimated by the model was approximately 12 times that of confirmed cases. This aligned well with an independent estimate for
the state of South Carolina. |
|
Meagher, BR, Cheadle, et al |
Journal of Environmental Psychology |
Mental Health |
|
In this study, we explored how one's attachment to their home may help to buffer their mental health during this stressful
time. We found a clear relationship between an individual's attachment to home and positive mental health. Predictors of home attachment included conscientiousness, agreeableness, and restorative ambience. The home may buffer some individuals from depressive
and anxiety-related symptoms by functioning as a source of refuge, security, and stability. |
|
|
Emotion recognition changes in a confinement situation due to COVID-19 |
Meléndez, JC, Satorres, et al |
Journal of Environmental Psychology |
Mental Health |
|
The aim of this study was to find out if there were differences in facial emotion recognition in two groups of young
adults, one confined during COVID-19 and the other unconfined. The main results obtained showed that during the confinement situation there was a significant decrease in the recognition of happiness, and a significant increase in the recognition of sadness
and depressed mood. Confinement has implications for mental health and emotional and social functioning. |
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COVID-19 presenting as fulminant hepatic failure: A case report |
Melquist, S, Estepp, et al |
Medicine |
Clinical data| Données cliniques |
Present a case of a young woman with SLE who developed severe abdominal pain, nausea and vomiting, rapidly progressing
to acute hepatic failure and tested positive for SARS-CoV-2 infection. She had no respiratory symptoms. The patient was started on hydroxychloroquine due to SLE, treated with N-Acetyl-Cysteine, and methylprednisolone. The patient improved with resolution of
encephalopathy and normalization of her liver chemistries without any development of respiratory illness. |
|
Mira, JJ, Carrillo, et al |
BMJ Open |
Mental Health |
|
OBJECTIVES: To determine the volume of health professionals who suffered distress due to their care of patients with
COVID-19 and to analyse the direction in which the response capacity of the professionals to face future waves of COVID-19 is evolving. DESIGN: A cross-sectional study. OUTCOME MEASURES: Frequency and intensity of stress responses measured by the Acute Stress
of Health Professionals Caring COVID-19 Scale (EASE). RESULTS: The average score on the EASE Scale was 11.1 out of 30. Among the participants, 44.2% presented a good emotional adjustment, 27.4% a tolerable level of distress, 23.9% medium-high emotional load
and 4.5% extreme acute stress. The stress responses were more intense in the most affected territories and during the disillusionment phase |
|
|
Electrocardiographic Changes and Arrhythmias in Hospitalized Patients With COVID-19 |
Moey, MYY, Sengodan, et al |
Circulation.Arrhythmia and electrophysiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Patients 18 or older with confirmed COVID-19 hospitalized at Vidant medical Center between March 1 to April 26, 2020
were retrospectively identified. Predominant arrhythmia was sinus tachycardia, PR interval significantly prolonged during hospitalization. Similarly QRS duration increased significantly. |
|
Mogami, T, Onuma, et al |
Int J Gynaecol Obstet |
Mental Health |
|
We conducted a retrospective study, wherein we included patients from our hospital with gynecologic cancers who had
been screened for anxiety and depression during the Japanese government-ordered state of emergency against COVID-19. We found that anxiety scores were higher in patients undergoing treatment than in the follow-up group. One third of the patients undergoing
cancer treatment showed a significantly high anxiety score. Surprisingly, 50% of patients showed a high depression score in both groups, which was higher than the proportion in a previous study. Patients who were tested at least three times expressed a recovering
trend by the end of the state of emergency. |
|
|
Moonen, HPFX, van Zanten, et al |
Clinical Nutrition |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of the present study was to assess the body composition of COVID-19 patients admitted to the ward or the ICU
and identify any associations with severity of disease. Methods: We performed an observational cross-sectional cohort study. Bioelectric impedance analysis was conducted amongst all confirmed COVID-19 patients admitted to the ward or ICU of our hospital in
the Netherlands, between April 10 and 17, 2020. Results: Body composition values were not independently associated with disease severity. In multiple logistic regression analyses, a low phase angle was associated with COVID-19 severity in the composite score. |
|
|
Moorthy, RK, Rajshekhar, et al |
Neurology India |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
The aim of the study was to assess present practice and perceptions among Indian neurosurgeons with respect to type
of surgeries performed, PPE usage and SARS-CoV-2 testing. A 12-item questionnaire on surgeries performed in the 6 weeks prior to the survey date, PPE usage, and preoperative SARS-CoV-2 testing was circulated electronically to Indian neurosurgeons from May
12, 2020 to May 31, 2020 and their responses analyzed. Two hundred forty-four neurosurgeons (237 males) participated in the survey; of whom, 230 had performed surgeries during the pandemic period. In total, 84.3% of respondents were performing semiemergency
or emergency procedures only. N95 masks were utilized by only 83% of the respondents (n = 230) while performing surgical procedures. Only 40.9% of the respondents were satisfied regarding adequacy of available PPE. Preoperative SARS-CoV2 testing as well as
testing of all asymptomatic patients prior to admission into ward/intensive care unit was perceived to be beneficial in reducing transmission risk by more than 85% respondents. More than 90% respondents felt that HCWs including neurosurgeons were at risk of
acquiring infection through an outpatient consultation from an asymptomatic individual. |
|
|
Nadeem, R, Thomas, et al |
Heart and Lung |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
In this retrospective study we sought to define the anticoagulation pattern and its impact on outcomes (28-day survival,
LOSICU, DVT, and PE and bleeding complications. We also observe if levels of d-Dimers affect the anticoagulation prescription. Overall , prescription of anticoagulation is quite variable in patients admitted to ICU for Covid-19 associated ARDS. Anticoagulation
dosing strategy has no significant effect on 28-day survival, LOSICU, the occurrence of DVT, PE, or bleeding. |
|
|
Ñamendys-Silva, SA, Alvarado-Ávila, et al |
Heart and Lung |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The present multicenter observational study evaluated the clinical characteristics and outcomes of critically ill
patients with severe COVID-19 who were admitted to ICUs in Mexico. Results indicate that critically ill patients with laboratory-confirmed COVID-19 who were admitted to the ICU in Mexico demonstrated that age and C-reactive protein level upon ICU admission
were associated with in-hospital mortality, and the overall hospital mortality rate was high. |
|
|
Viral protein engagement of GBF1 induces host cell
vulnerability through synthetic lethality |
Navare, ArtiT, Mast, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study extended the application of this synthetic lethality principle to host-derived antiviral targets. Synthetic
lethal interactions of viral-induced hypomorphs have the potential to be targeted for the development of host-based antiviral therapeutics. This study used GBF1, which supports the infection of many RNA viruses, as a proof-of-concept. GBF1 becomes a hypomorph
upon interaction with the poliovirus protein 3A. Screening for synthetic lethal partners of GBF1 revealed ARF1 as the top hit, disruption of which, selectively killed cells that synthesize poliovirus 3A. Thus, viral protein interactions can induce hypomorphs
that render host cells vulnerable to perturbations that leave uninfected cells intact. Exploiting viral-induced vulnerabilities could lead to broad-spectrum antivirals for many viruses, including SARS-CoV-2. |
|
Navarro, C, Yáñez, et al |
Medicine (Baltimore) |
Mental Health |
|
Clinical trial proposal. Evaluated the effectiveness of an Internet-based adjuvant lifestyle-based intervention for
patients with treatment-resistant depression (TRD). This will be a parallel, randomized, and controlled clinical trial. A total of 180 patients with TRD will be randomly allocated (1:1:1) to 1 of 3 groups and will administer interventions by teletherapy, and
contact participants by telephone calls, text messages, and/or teleconferences. The primary outcome will be score on the Beck Depression Inventory-II. The secondary outcomes will be score on the Clinical Global Impressions Scale (used to quantify and track
patient progress and treatment response over time) and health-related quality of life measured using the European Quality of Life-5 Dimensions Questionnaire. |
|
|
Heparin Therapy Improving Hypoxia in COVID-19 Patients – A Case Series |
Negri, EM, Piloto, et al |
Frontiers in Physiology |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We describe a series of 27 consecutive COVID-19 patients admitted to Sirio-Libanes Hospital in São Paulo-Brazil and
treated with heparin in therapeutic doses tailored to clinical severity. PaO2/FiO2 ratio increased significantly over the 72 h following the start of anticoagulation, from 254(±90) to 325(±80), p = 0.013, and 92% of the patients were discharged home within
a median time of 11 days. There were no bleeding complications or fatal events. |
|
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans |
Ng, KW, Faulkner, et al |
Science |
Immunology | Immunologie |
Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detect preexisting humoral immunity. SARS-CoV-2
spike glycoprotein (S)-reactive antibodies were detectable by a flow cytometry-based method in SARS-CoV-2-uninfected individuals and were particularly prevalent in children and adolescents. By contrast, SARS-CoV-2 infection induced higher titers of SARS-CoV-2
S-reactive IgG antibodies, targeting both the S1 and S2 subunits, and concomitant IgM and IgA antibodies, lasting throughout the observation period. Notably, SARS-CoV-2-uninfected donor sera exhibited specific neutralizing activity against SARS-CoV-2 and SARS-CoV-2
S pseudotypes. |
|
Nikčević, AV, Marino, et al |
Journal of affective disorders |
Mental Health |
|
In the current study we sought to extend our understanding of vulnerability and protective factors in predicting generalised
anxiety and depressive symptoms during the COVID-19 pandemic in the US. Results showed that health anxiety, COVID-19 anxiety, and the COVID-19 anxiety syndrome partially mediated the relationship between the Big Five personality traits and generalised anxiety
and depressive symptoms. |
|
|
Nikolaev, EN, Indeykina, et al |
J Proteome Res |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We have developed a mass-spectrometry-based method for the detection of the SARS CoV-2 virus in nasopharynx epithelial
swabs based on the detection of the viral nucleocapsid N protein. Our approach shows confident identification of the N protein in patient samples, even those with the lowest viral loads, and a much simpler preparation procedure. |
|
|
Analysis of public reactions to the novel Coronavirus (COVID-19) outbreak on Twitter |
Noor, S, Guo, et al |
Kybernetes |
Public Health response| Interventions de santé publique |
The purpose of this study is to explore and analyze the general public reactions to the COVID-19 outbreak on Twitter.
This study conducts a thematic analysis of COVID-19 tweets through VOSviewer to examine people’s reactions related to the COVID-19 outbreak in the world. |
|
O’ Neill, SB, Byrne, et al |
Canadian Association of Radiologists Journal |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We aim to compare diagnostic performance and inter-/intra-observer among chest radiologists in the interpretation of
RSNA and CO-RADS reporting systems and assess clinician preference. Methods: Chest CT scans of 279 patients with suspected COVID-19 who underwent RT-PCR testing were retrospectively and independently examined by 3 chest radiologists who assigned interpretation
according to the RSNA and CO-RADS reporting systems. Results: Both systems demonstrated almost perfect inter-observer agreement. Positive predictive values were high, 0.798-0.818 for RSNA and 0.891-0.903 CO-RADS. Negative predictive value were similar, 0.573-0.585
for RSNA and 0.573-0.58 for CO-RADS. Specificity differed between the 2 systems, 68-73% for CO-RADS and 52-58% for RSNA with superior specificity of CO-RADS. |
|
|
Oksanen, A, Savolainen, et al |
Alcohol Alcohol |
Mental Health |
|
The aim of this study was to analyze psychological stressors predicting increased drinking during the COVID-19 crisis.
One-fourth of Finnish workers (25.37%) reported increased drinking during the COVID-19 crisis. Cyberbullying victimization at work and psychological distress before the crisis predicted increased drinking during the crisis. Conscientious workers and those
working in educational and health and welfare sectors were less likely to increase drinking, while increased drinking was most common among workers under 30 years of age. |
|
|
Olmos, C, Stuardo, et al |
Revista medica de Chile |
Epidemiology| Épidémiologie |
Aim: To describe the epidemiological behavior of COVID-19 in response to the control strategies implemented by the
Chilean Ministry of Health and its similarities with the socio-economic distribution of TB in the Metropolitan Region (MR) of Chile. Material and Methods: The 2018 Tuberculosis rates and average income of districts belonging to the MR were described, as well
as the incidence rates of COVID-19. Results: The RM accounts for over 50% of the total national cases of COVID-19. After the implementation of selective quarantines, only four districts in the RM managed to control the outbreak (those with the highest incomes). |
|
|
Pagano, AM, Maiese, et al |
International Journal of Environmental Research and Public Health |
Public health interventions*| Interventions de sant&eacute; publique Surveillance |
(1) Background: The emergency linked to the spread of COVID‐19 in Italy has led to inevitable consequences on the penitentiary
system. The risks of this emergency in prisons is mainly related to the problem of persistent overcrowding that makes social distancing difficult and the isolation of any contagion hard to arrange. The Department of Protection for Adults and Minors of the
ASL Salerno Criminal Area has taken steps in order to perform screening operations and minimize the risks for prisoners and operators. (2) Methods: We conducted a two‐phase observational study. In the first phase, we offered and then executed serum COVID‐19
screening to all the convicted inmates. For those who had a doubtful or positive result, a swab was executed in the shortest time possible. In the second phase, a pharyngeal swab was offered and executed to all the police officers, the penitentiary administrative
staff and the medical personnel working in the prison. (3) Results: In the first phase, we executed 485 COVID‐19 blood tests on prisoners, 3 (0.61%) of which were positive. The three positive inmates underwent nasopharyngeal swabbing, which ultimately were
negative. After that, we executed 276 nasopharyngeal swabs on the prison personnel, penitentiary administrative staff and medical personnel—all were negative. (4) Conclusion: All tests (blood tests and swabs) that were carried out on the prisoners and on the
staff were negative for COVID‐19. We believe that all prisons in Italy and in the world should take action to ensure preventive and control measures in order to safeguard the health of the prison population and of all the people who work there. © 2020 by the
authors. Licensee MDPI, Basel, Switzerland. |
|
|
Optimal Resource and Demand Redistribution for Healthcare Systems Under Stress from COVID-19 |
Parker, Felix, Sawczuk, et al |
arXiv |
Healthcare Response | Réponse des soins de santé |
This study examined the problem of finding optimal demand and resource transfers to minimize the required surge capacity
and resource shortage during a period of heightened demand. The models used were validated retrospectively using COVID-19 hospitalization data from New Jersey, Texas, and Miami, yielding at least an 85% reduction in required surge capacity relative to the
observed outcome of each case. Results show that such solutions are operationally feasible and sufficiently robust against demand uncertainty. |
|
periscope: Sub-Genomic RNA Identification in SARS-CoV-2
Genomic Sequencing Data |
Parker, Matthew Daniel, Lindsey, et al |
bioRxiv |
Coronavirology| Coronavirologie |
This research developed periscope, a tool for the detection and quantification of sub-genomic RNA (sgRNA) in SARS-CoV-2
genomic sequence data. Applied periscope to 1,155 SARS-CoV-2 genomes from Sheffield, UK and validated the findings using orthogonal datasets and in vitro cell systems. Using a simple local alignment to detect reads which contain the leader sequence, able to
identify and quantify reads arising from canonical and non-canonical sgRNA. Detected all canonical sgRNAs at expected abundances, with the exception of ORF10. A number of recurrent non-canonical sgRNAs are detected. These results are reproducible using technical
replicates and determine the optimum number of reads for sgRNA analysis. In VeroE6 ACE2 cell lines, periscope can detect the changes in the kinetics of sgRNA in orthogonal sequencing datasets. |
|
COVID-19 Could Trigger Systemic Juvenile Idiopathic Arthritis: First Case
Report |
Parvaneh, Vadood Javadi, Rahmani, et al |
Research Square prepub |
Clinical data| Données cliniques |
We report a 7 years-old boy with COVID-19 first presented with an acute abdomen. Then he showed pictures of Kawasaki-like
syndrome, a multiorgan inflammatory syndrome in children (MIS-C), and finally systemic juvenile idiopathic arthritis. |
|
Knowledge about covid-19 and practices among hemodialysis technicians in the covid-19
pandemic era |
Pasari, AS, Bhawane, et al |
International Journal of Nephrology |
Healthcare Response | Réponse des soins de santé |
This study assesses the knowledge and attitude towards COVID-19 among hemodialysis technicians in this pandemic situation.
Most of the respondents could correctly identify fever (87.8%), breathlessness (86.08%), and dry cough (81.7%) as the symptoms of COVID-19 infection. 75.7% of the technicians were aware that it can be transmitted by asymptomatic persons. 61.1% of the technicians
were segregating patients who had symptoms such as fever and cough to the last shift of the day. 81.1% of the technicians read the guidelines issued by the Indian Society of Nephrology—COVID-19 working group. But, only 25.5% of the respondents could rightly
identify to keep a minimum distance of two meters between two beds while dialyzing a suspected patient of COVID-19 along with other patients to minimise risk of COVID-19 transmission. 60% of the technicians have received hydroxychloroquine as prophylaxis against
coronavirus infection. |
|
Pasco, RF, Fox, et al |
JAMA network open |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission
Public health interventions*| Interventions de sant&eacute; publique |
The objective of this study was to assess the association between construction work during the COVID-19 pandemic and
hospitalization rates for construction workers and the surrounding community. This decision analytical model used a mathematical model of COVID-19 transmission, stratified by age and risk group, with construction workers modeled explicitly. The findings of
this study suggest that unrestricted work in high-contact industries, such as construction, is associated with a higher level of community transmission, increased risks to at-risk workers, and larger health disparities among members of racial and ethnic minority
groups. |
|
|
Pasion, R, Paiva, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
The present study focuses on the age-related differences on the adoption of protective behaviors during the initial
stages of this outbreak, while accounting for the role of sociodemographic, COVID-related, perceived risk, and psychosocial variables (i.e., anxiety, optimism, fear of death, and social isolation) in this relation. The study sample included 1696 participants,
aged between 18 and 85 years old, who completed an online survey during the initial stages of the first COVID-19 outbreak in Portugal. Overall, results reveal that the engagement in protective behaviors declines with advancing age and that older adults show
a pattern toward lower perceived risk compared with middle-aged adults. Multicategorical mediation analyses show that anxiety, optimism, fear of death, and social isolation significantly mediate age effects on protective behaviors. Specifically, both anxiety
and fear of death increase protective behaviors via higher perceived risk in the middle-aged and in the younger groups, respectively. Optimism directly predicts protective behaviors in the middle-aged groups, while social isolation reduces protective behaviors
in the younger and older-aged groups. |
|
|
Patel, PC, Rietveld, et al |
Journal of Business Venturing Insights |
Mental Health |
|
Using data from the Understanding America Study, we show that relative to wage workers, the self-employed experience
greater psychological distress through self-reported financial insecurity (the chance of running out of money). Using additional cross-sectional data from the COVID-19 Household Impact Survey, we show that the self-reported chance of job loss disproportionally
impacts the psychological distress of the self-employed. Together, these results underscore that the economic uncertainties induced by the COVID-19 pandemic hit the self-employed particularly harsh by deteriorating short-term psychological distress. |
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COVID-19 and Living Donor Kidney Transplantation in Naples during the Pandemic |
Peluso, G, Campanile, et al |
BioMed Research International |
Healthcare Response | Réponse des soins de santé |
This study examined the transplantation activity to explore the future role of kidney transplantation from deceased
and living donors in COVID-19 era. . From March 9, 2020, when the Italian lockdown begun, till June 9, 2020, five kidney transplants have been performed, all from deceased donors. The donors and the recipients have been screened for COVID-19 infection, and
the patients, all asymptomatic, followed strict preventive measures and were fully informed about the risks of surgery and immunosuppression during a pandemic. All the transplanted patients remained COVID negative during the follow-up. The number of transplants
performed has been constant compared to the same months of 2018 and 2019. In agreement with the patients, decided to postpone living donor transplants to a period of greater control of the SARS-CoV-2 spread in Italy. |
|
Encephalopathy in COVID-19 Presenting With Acute Aphasia Mimicking Stroke |
Pensato, U, Muccioli, et al |
Frontiers in Neurology |
Clinical data| Données cliniques |
Case report of a middle-aged man presented with acute language disturbance at the emergency department. Examination
revealed expressive aphasia, mild ideomotor slowing, and severe hypocapnic hypoxemia. Multimodal CT assessment and electroencephalogram (EEG) did not reveal any abnormalities. COVID-19 was diagnosed based on chest CT findings and positive severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) reverse transcription PCR (RT-PCR) on nasopharyngeal swab. The following day, neurological symptoms progressed to agitated delirium and respiratory status worsened, requiring admission to the ICU and mechanical ventilation. |
|
Perkmann, Thomas, Perkmann-Nagele, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
To increase sensitivity, cut-offs of three commercially available SARS-CoV-2 automated assays (Roche, Abbott, and DiaSorin)
were reduced according to published values in a pre-pandemic specificity cohort (n=1117) and a SARS-CoV-2 positive cohort (n=64). All three testing systems were combined in an orthogonal approach with a confirmatory test, which was one of the remaining automated
assays or one of two commercial ELISAs directed against the spike protein receptor binding-domain (RBD) or the nucleocapsid antigen (NP). The modified orthogonal test strategy resulted in an improved specificity of at least 99.8%, often even 100%, in all 12
tested combinations with no significant decline in sensitivity. In our cohort, regardless of whether the assays were used for screening or confirmation, combining Roche and Abbott delivered the best overall performance (+~10% sensitivity compared to the single
tests and 100% specificity). |
|
|
Perrone, T, Soldati, et al |
J Ultrasound Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The purpose of this study was to evaluate the potential prognostic value of a new lung ultrasound (LUS) protocol in
patients with SARS-CoV-2 pneumonia and the association of LUS patterns with clinical or laboratory findings. A median LUS score higher than 24 was associated with an almost 6-fold increase in the odds of worsening. |
|
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A whole blood test to measure SARS-CoV-2-specific response in COVID-19 patients |
Petrone, L, Petruccioli, et al |
Clinical Microbiology and Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Methods: We evaluated interferon (IFN)-γ levels after stimulating whole-blood with spike and remainder-antigens peptides
megapools (MP) derived from SARS-CoV-2 sequences. Results: IFN-γ-response to spike and remainder-antigens MPs was significantly increased in 35 COVID-19 patients compared with 29 ‘no COVID-19’ individuals. This response was detected independently of patients'
clinical parameters. IFN-γ-response to SARS-CoV-2-unrelated antigens cytomegalovirus (CMV) and Staphylococcal Enterotoxin B (SEB) was similar in COVID-19 compared with ‘no COVID-19’ individuals. Immune response to SARS-CoV-2 peptides in a whole-blood assay
is associated with COVID-19 and it is characterized by both Th1 and Th2 profile. |
|
Pirsalehi, A, Salari, et al |
Iranian Journal of Microbiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective Double-Centre study was conducted on 1320 COVID-19 patients recruited at Taleghani and Shohadae
Tajrish Hospitals in Tehran, Iran. We analyzed the leukocyte, lymphocyte and neutrophil counts of hospitalized cases both on admission and at discharge. Of the whole, 1077 (81.6%) neither were admitted to intensive care unit (ICU) nor experienced death, and
were defined as the mild-moderate group. Of 243 severe cases, while 59 (24.3%) were admitted to ICU and cured with the intensive care services, 184 (75.7%) patients died of the disease, either with or without ICU admission. Calculation of neutrophil-to-lymphocyte
ratio (NLR) revealed that the mild-moderate cases had a lower ratio at discharge. On the other hand, the ratio was significantly higher in the death group as compared to the ICU group; highlighting the fact that patients with a higher degree of neutrophilia
and a greater level of lymphopenia have a poor prognosis. |
|
|
PMC7334957; Free-floating right heart thrombus with pulmonary embolism in SARS-CoV-2
patient |
Pla, JJ, Rodriguez, et al |
Med Clin (Barc) |
Clinical data| Données cliniques |
A 56-year-old caucasian male with morbid obesity (BMI 45 kg/m2), with 15-day history of dyspnea, myalgia and dry cough,
was admitted to emergency room. First rapid SARS-CoV-2 PCR was negative, but with high clinical suspicion, pharmacological treatment was started. Tachypnea and dry crackles were observed at physical examination. |
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PMC7476580; Longitudinal evaluation of the psychological impact of the COVID-19
crisis in Spain |
Planchuelo-Gómez, Á, Odriozola-González, et al |
J Affect Disord |
Mental Health |
|
The aim was to assess the temporal evolution of the psychological impact of the COVID-19 crisis and lockdown from two
surveys, separated by one month, performed in Spain. Results indicated a temporal increase of anxiety, depression and stress scores during the COVID-19 lockdown. Factors such as age, consumption of information about COVID-19 and physical activity seem to have
an important impact on the evolution of psychological symptoms. |
|
The Experience of COPD Patients in Lockdown Due to the COVID-19 Pandemic |
Pleguezuelos, E, Del Carmen, et al |
International journal of chronic obstructive pulmonary disease |
Healthcare Response | Réponse des soins de santé |
This study from Spain explores the impact of this lockdown on the manifestations of COPD and the quality-of-life of
these patients. Our results indicate that in general lockdown had a low impact on COPD patients. Only one patient was hospitalized by COVID-19, but moderate exacerbations of COPD were not infrequent. Although many medical visits and test were cancelled, patients
were very satisfied with the medical telephone visits. |
|
Politis, C, Papadaki, et al |
Transfusion Clinique et Biologique |
Transmission Clinical data| Données cliniques |
As yet there are no reports of transfusion transmission of COVID-19. Haemovigilance findings within a three-month surveillance
period during the new coronavirus pandemic are presented. Post-donation, post-transfusion information and molecular testing of swab samples collected from three asymptomatic donors at risk for COVID-19, revealed the case of an immunosupressed patient who had
been transfused with whole blood derived platelets from a donor subsequently diagnosed with COVID-19. The recipient exhibited no symptoms of the disease. Molecular and antibody testing results were negative. Haemovigilance provided information supporting the
absence of transfusion transmission of COVID-19, thus strengthening the hypothesis that, even if it cannot yet be definitively ruled out, COVID-19 is not transmitted through blood transfusion. |
|
|
Pollet, Jeroen, Chen, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins Animal model | Modèle animal |
This study reports on the development of a SARS-CoV-2 receptor-binding domain (RBD) protein, expressed at high levels
in yeast (Pichia pastoris), as a suitable vaccine candidate against COVID-19. After introducing two modifications into the wild-type RBD gene to reduce yeast-derived hyperglycosylation and improve stability during protein expression, this study shows that
the recombinant protein, RBD219-N1C1, is equivalent to the wild-type RBD recombinant protein (RBD219-WT) in an in vitro ACE-2 binding assay. Immunogenicity studies of RBD219-N1C1 and RBD219-WT proteins formulated with Alhydrogel® were conducted in mice, and,
after two doses, both the RBD219-WT and RBD219-N1C1 vaccines induced high levels of binding IgG antibodies. Using a SARS-CoV-2 pseudovirus, further showed that sera obtained after a two-dose immunization schedule of the vaccines were sufficient to elicit strong
neutralizing antibody titers in the 1:1,000 to 1:10,000 range, for both antigens tested. The vaccines induced IFN-γ, IL-6, and IL-10 secretion, among other cytokines. |
|
|
Poteat, TC, Reisner, et al |
J Acquir Immune Defic Syndr |
Epidemiology| Épidémiologie Public Health Priorities| Priorités de santé publique |
Baseline data from the American Cohort to Study HIV Acquisition Among Transgender Women in High Risk Areas (LITE) Study
were examined for pre-COVID factors that may increase vulnerability to COVID-19-related harms among transgender women. The 1020 participants had high rates of poverty, unemployment, food insecurity, homelessness, and sex work. Transgender women with HIV (n
= 273) were older, more likely to be Black, had lower educational attainment, and were more likely to experience material hardship. Mental and behavioral health symptoms were common and did not differ by HIV status. Barriers to health care included being mistreated,
provider discomfort serving transgender women, and past negative experiences; as well as material hardships, such as cost and transportation. However, most reported access to material and social support—demonstrating resilience. |
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|
Prachthauser, M, Cassisi, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
This paper describes the development of a brief self-report screening measure ( 29 questions) of adherence to social
distancing and self-protective behaviors in pandemic situations. Items measured behaviors currently established as primary strategies to prevent and reduce the spread of the COVID-19 infection. Responses were collected from 401 young adults using an anonymous
online survey. A 14-item Social Distance Scale emerged, consisting of four subscales: Isolation from Community (IC), Work from Home (WH), Family Contact (FC), and Protective Behaviors (PB). The initial psychometric evaluation of the scales indicated adequate
internal consistency and test-retest reliability. |
|
|
Prashantha, CN, Gouthami, et al |
Journal of Molecular Graphics and Modelling |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Several drugs such as antimalarial, antibiotic, anti-inflammatory and HIV-protease inhibitors are currently undergoing
treatment as clinical studies to test the efficacy and safety of COVID-19. Some promising results have been observed with the patients and also with high mortality rate. Hence, there is a need to screen the best CoV inhibitors using insilico analysis. The
insilico pharmacological evaluation shows that these molecules exhibit good affinity of drug-like and ADMET properties. Hence, we propose that HIVprotease, anti-inflammatory and antibiotic inhibitors are the potential lead drug molecules for spike protein
and preclinical studies needed to confirm the promising therapeutic ability against COVID-19. |
|
|
Qiang, Min, Ma, et al |
bioRxiv |
Coronavirology| Coronavirologie Immunology | Immunologie |
This study used a combinatorial human antibody library constructed 20 years before the COVID-19 pandemic to discover
three highly potent antibodies that selectively bind SARS-CoV-2 spike protein and neutralize authentic SARS-CoV-2 virus. Compared to neutralizing antibodies from COVID-19 patients with generally low somatic hypermutation (SHM), these antibodies contain over
13-22 SHMs, many of which are involved in specific interactions in crystal structures with SARS-CoV-2 spike RBD. The identification of these somatically mutated antibodies in a pre-pandemic library raises intriguing questions about the origin and evolution
of human immune responses to SARS-CoV-2. |
|
|
Qin, Bo, Craven, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study describes the successful application of quantitative irreversible tethering (qIT) to identify acrylamide
fragments that selectively target the active site cysteine of the 3C protease (3Cpro) of Enterovirus 71, the causative agent of hand, foot and mouth disease in humans, altering the substrate binding region. Re-purposed these hits towards the main protease
(Mpro) of SARS-CoV-2 which shares the 3C-like fold as well as similar catalytic-triad. And demonstrated that the hit fragments covalently link to the catalytic cysteine of Mpro to inhibit its activity. Also demonstrated that targeting the active site cysteine
of Mpro can also have profound allosteric effects, distorting secondary structures required for formation of the active dimeric unit of Mpro. These new data provide novel mechanistic insights into the design of EV71 3Cpro and SARS-CoV-2 Mpro inhibitors and
identify acrylamide-tagged pharmacophores for elaboration into more selective agents of therapeutic potential. |
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|
Influence of Malaria Edemicity and TB Prevalence
/ BCG Coverage on COVID-19 Mortality |
Raham, Tareef Fadhil |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Investigate the influence of the possible role of latent TB and malaria creating innate cross heterogeneous immunity
by analyzing COVID -19 mortality in malarious countries. The results show with robust statistical support that standardized TB prevalence is significantly associated with reduced COVID-19 mortality. Malaria have an additional effect in reducing COVID-19 mortality
with highly significant association. Conclusions: Malaria and standardized TB prevalence are statistically significant factors predicting COVID-19 mortality in negative associations. |
|
Rahman, MM, Thill, et al |
Sustainability (Switzerland) |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
This study empirically investigates the complex interplay between the severity of the coronavirus pandemic, mobility
changes in retail and recreation, transit stations, workplaces, and residential areas, and lockdown measures in 88 countries around the world during the early phase of the pandemic. A Structural Equation Modeling (SEM) framework is used to investigate the
direct and indirect effects of independent variables on dependent variables considering the intervening effects of mediators. Results show that lockdown measures have significant effects to encourage people to maintain social distancing so as to reduce the
risk of infection. Countries with a higher number of elderly people, employment in the service sector, and higher globalization trend are the worst victims of the coronavirus pandemic (e.g., USA, UK, Italy, and Spain). Social distancing measures are reasonably
effective at tempering the severity of the pandemic. |
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Cardiothoracic surgery during COVID-19: Our experience with different strategies |
Ralhan, S, Arya, et al |
Annals of cardiac anaesthesia |
Healthcare Response | Réponse des soins de santé |
The retrospective study is aimed to provide a protocol for pre-operative testing of SARS CoV-2 using RT-PCR in the
patient undergoing cardio-thoracic surgeries. During the early phase (phase I), 26 patients underwent cardio-thoracic surgery without COVID-19 RT-PCR test. Whereas, during phase II, all patients were tested for COVID-19 using RT-PCR, preoperatively and a total
of 64 surgeries were performed during this phase. One patient planned for CABG was positive on RT-PCR for COVID-19 and was sent to the quarantine ward. The difference in the pre-operative hospital stay between two groups was found to be statistically significant
and a significant decrease in the number of PPE kits used, during the phase I. |
|
Ramos, Willy, Arrasco, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Determined the epidemiological characteristics of deaths from COVID-19 in Peru from March 28 to May 21, 2020, 85 days
after the report of the first confirmed case. 3,244 confirmed deaths were included in the study. Deaths were more frequent in males (71.8%), elders (68.3%), residents of the department of Lima (41.8%), and others from the coast (37.7%). In 81.3% of cases,
the death occurred in a public hospital, 16.0% died at home, shelter, penitentiary institution, public highway, or in transit to a hospital, and 31.1% had some comorbidity. Statistical difference was observed in pre-hospital time according to age group and
gender, being significantly higher in adults, elders, and women. There was a statistically significant difference in hospital time according to geographic area, showing a significantly shorter time in the departments of the coast and Andean region compared
to Lima. The cases that were seen in private clinics survived longer than those seen in public hospitals. |
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|
Rana, MM, Abdelhadi, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper proposes an innovative COVID-19 stochastic model to secure communication systems for transferring and storing
epidemic data. Considering the observable and non-observable COVID-19 states such as infection, confirmed/unconfirmed cases, recovery, and reported/unreported deaths, the dynamic COVID-19 framework is developed and verified. For predicting COVID-19 model,
an optimal signal processing algorithm is developed and implemented. Based on the designed gain, the dynamic system forecasting error is reduced to develop an accurate COVID-19 prediction method. Extensive results show that the proposed technique can properly
forecast COVID-19 states within a short period of time. |
|
|
Young adults' personal concerns during the COVID-19 pandemic in Finland: an issue
for social concern |
Ranta, M, Silinskas, et al |
International Journal of Sociology and Social Policy |
Mental Health |
|
This study focuses on how young adults face the COVID-19 pandemic by investigating their personal concerns about mental
well-being, career/studies and economic situation. The authors investigated how young adults' (aged 18–29) personal concerns differ from older people's concerns (aged 30–65) and which person- and context-related antecedents relate to personal concerns. Young
adults were significantly more concerned about the effects of the COVID-19 pandemic on their mental well-being, career/studies and economic situation than older people. Females were more concerned about their mental well-being than males. Among youth, lower
life satisfaction was related to concerns about mental well-being, and lower satisfaction with financial situation was related to concerns about career/studies and economic situation. Young adults' predisposition to avoid difficult situations was related to
more frequent concerns in all domains, whereas generalized trust and education were not. |
|
The Impact of the COVID-19 Pandemic on Urology Practice in Indonesia: A Nationwide
Survey |
Rasyid, N, Birowo, et al |
Urol J |
Healthcare Response | Réponse des soins de santé |
In this cross-sectional study, urologists in Indonesia responded to an e-questionnaire regarding urology practice
during the COVID-19 pandemic. Of 369 practicing urologists 220 urology residents, 35 (9.5%) and 59 (26.8%), respectively, had been suspected as COVID-19 patients, of whom seven were confirmed to be COVID-19 positive. The majority (66%) continued face-to-face
consultations and more than 60% preferred to postpone elective surgery, particularly in cases where the patient had COVID-19 symptoms or required post-operative ICU care. Urologists and residents reported high rates of PPE use, with some supply issues. Results
suggest disruptions to urology services in Indonesia due to COVID-19 pandemic. |
|
ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-COV-2 in
Cancer Patients |
Ravaioli, S, Tebaldi, et al |
Cell transplantation |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
Considering the limited data on cancer patients, we analyzed public data repositories limited to investigate angiotensin-converting
enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) expressions and genetic variants to identify the basis of individual susceptibility to SARS-CoV-2. Allele frequencies of germline variants were explored in different ethnicities, with a special
focus on ACE2 variants located in the binding site to SARS-CoV-2 spike protein.The analysis of ACE2 and TMPRSS2 expressions in healthy tissues showed a higher expression in the age class 20 to 59 years regardless of gender. ACE2 and TMPRSS2 were more expressed
in tumors from males than females and, opposite to the regulation in tissues from healthy individuals, more expressed in elderly patients. |
|
Rayhan, Istihak, Akter, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
The study attempted to explore the prevalence and associated factors of Intimate Partner Violence (IPV) in Bangladesh
amid the COVID-19 pandemic. Results revealed that comparatively older women, employed, non-Muslims and women with educated husband were less likely to experience violence, while arranged marriage, family income reduction amid the pandemic and husbands’ pandemic
induced depression or anxiety caused more likely to commit violence. |
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Potential Cross-Reactive Immunity to SARS-CoV-2 From Common Human Pathogens and
Vaccines |
Reche, PA |
Frontiers in Immunology |
Immunology | Immunologie |
Authors explored the potential role of cross-reactive immunity acquired from pediatric vaccinations and exposure to
common human pathogens in the protection and pathology of COVID-19. Children may well be protected from SARS-CoV-2 through cross-reactive immunity elicited by DTP vaccinations, supporting testing in the general population to prevent COVID-19. |
|
Reddy, A, Engelhardt, et al |
AJP Reports |
Transmission Clinical data| Données cliniques |
We present here two very preterm infants born to mothers with COVID-19, whose respiratory course was significant for
initial mild respiratory distress syndrome who developed acute onset severe air leak syndrome at approximately 24 to 36 hours of age requiring thoracentesis. Their respiratory status improved gradually with resolution of air leak and respiratory failure by
2 weeks of age. Both infants tested negative for SARS-CoV-2 by reverse transcriptase-polymerase chain reaction of multiple respiratory specimens collected beyond 24 hours after birth. As the incidence of severe air leak syndrome is relatively low in preterm
infants without risk factors, this presentation in two very preterm infants born to mothers with COVID-19 is intriguing and needs to be further evaluated in larger cohorts. |
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Ren, C, Yao, et al |
Frontiers in Medicine |
Clinical data| Données cliniques |
Authors aimed to describe the clinical characteristics of COVID-19 patients in Shenzhen and identify risk factors for
the development of viral sepsis. SARS-CoV-2 infection-induced sepsis is critically involved in the severity and prognosis of COVID-19 patients by characterizing both aberrant immune response and uncontrolled inflammation. |
|
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Ren, Y, Qian, et al |
J Affect Disord |
Mental Health |
|
The purpose of this study was to investigate the mental health of the Chinese public during the long-term COVID-19
outbreak. Overall, 30.1% of smokers increased smoking, while 11.3% of drinkers increased alcohol consumption. The prevalence rates of depression, anxiety, mental health problems, high risk of suicidal and behavior, clinical insomnia, clinical post-traumatic
stress disorder symptoms, moderate-to-high levels of perceived stress were 18.8%, 13.3%, 7.6%, 2.8%, 7.2%, 7.0%, and 67.9%, respectively. Further, the geographical distribution showed that the mental status in some provinces/autonomous regions/municipalities
was relatively more serious. The temporal distribution showed that the psychological state of the participants was relatively poorer on February 20, 24 to 26 and March 25, especially on March 25. |
|
|
Ricoca Peixoto, V, Vieira, et al |
Acta Medica Portuguesa |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
The aim of this study was to estimate the initial impact of the lockdown in Portugal in terms of the reduction of the
burden on the healthcare system. We used exponential smoothing models for deaths, intensive care and hospitalizations and an ARIMA model for number of cases. Between April 1st and April 15th, there were 146 fewer deaths (-25%), 5568 fewer cases (-23%) and,
as of April 15th, there were 519 fewer intensive care inpatients (-69%) than forecasted without the lockdown. On April 15th, the number of intensive care inpatients could have reached 748, three times higher than the observed value (229) if the intervention
had been delayed. |
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Differing impacts of global and regional responses
on SARS-CoV-2 transmission cluster dynamics |
Rife Magalis, Brittany, Ramirez-Mata, et al |
bioRxiv |
Epidemiology| Épidémiologie Transmission Coronavirology| Coronavirologie |
In this study, clusters of transmission were inferred from a phylogenetic tree representing the relationships of patient
sequences sampled from December 30, 2019 to April 17, 2020. Metadata comprising sampling time and location were used to define the global behavior of transmission over this earlier sampling period, but also the involvement of individual regions in transmission
cluster dynamics. Results demonstrate a positive impact of international travel restrictions and nationwide lockdowns on global cluster dynamics. However, residual, localized clusters displayed a wide range of estimated initial secondary infection rates, for
which uniform public health interventions are unlikely to have sustainable effects. These findings highlight the presence of so-called "super-spreaders", with the propensity to infect a larger-than-average number of people, in countries, such as the USA. |
|
Ripperger, TJ, Uhrlaub, et al |
Immunity |
Clinical data| Données cliniques Immunology | Immunologie |
We conducted a serological study to define correlates of immunity against SARS-CoV-2. Compared to those with mild coronavirus
disease 2019 (COVID-19) cases, individuals with severe disease exhibited elevated virus-neutralizing titers and antibodies against the nucleocapsid (N) and the receptor binding domain (RBD) of the spike protein. Age and sex played lesser roles. All cases,
including asymptomatic individuals, seroconverted by 2 weeks after PCR confirmation. Spike RBD and S2 and neutralizing antibodies remained detectable through 5–7 months after onset, whereas α-N titers diminished. Testing 5,882 members of the local community
revealed only 1 sample with seroreactivity to both RBD and S2 that lacked neutralizing antibodies. |
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Rodríguez-Molinero, A, Pérez-López, et al |
Medicina clinica |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Analyzed whether there is an association between the use glucocorticoids at high doses, and the evolution of saturation/fraction
of inspired oxygen (SAFI) or time to discharge, in patients hospitalized with COVID-19. There were 187 patients treated with glucocorticoids; of these, 25 patients could be matched with an equivalent number of control patients. In the analysis of these matched
sub-cohorts, no significant difference was observed in time to discharge or the increment in SAFI at 48 hours of treatment (glucocorticoides: −0.04; controls: +0.37). Multivariate models using Cox regression showed a significantly longer time to discharge
in patients treated with glucocorticoids. We have not found improvement in respiratory function or time until discharge, associated with the use of glucocorticoids at high doses. |
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Working in the Times of COVID-19. Psychological Impact of the Pandemic in Frontline
Workers in Spain |
Rodríguez-Rey, R, Garrido-Hernansaiz, et al |
Int J Environ Res Public Health |
Mental Health |
|
This study evaluates the psychological impact (PI) of the COVID-19 pandemic in frontline workers in Spain. Participants
were 546 workers (296 healthcare workers, 105 media professionals, 89 grocery workers, and 83 protective service workers). They all completed online questionnaires assessing PI, sadness, concerns related to the COVID-19 pandemic, and demographic and work-related
variables. All groups but protective services workers showed higher PI levels than the general population. Healthcare and grocery workers were the most affected, with 73.6% and 65.2% of the participants, respectively, showing a severe PI. Women showed a higher
PI level. Healthcare workers in the regions with higher COVID-19 incidences reported greater PI levels. The main concerns were being infected by COVID-19 or infecting others. Levels of concern correlated with higher PI levels. The protection equipment was
generally reported as insufficient, which correlated with higher PI levels. Professionals reporting to overwork during the crisis (60% mass-media, 38% of healthcare and grocery and 21.7% of protective service) showed higher PI levels. In the healthcare group,
taking care of patients with COVID-19 (77%) or of dying patients with COVID-19 (43.9%) was associated with higher PI levels. The perceived social recognition of their work was inversely related to PI. Most of the sample had not received psychological support. |
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Beyond the peak: A deterministic compartment model
for exploring the Covid-19 evolution in Italy |
Romano, S, Fierro, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Combining the surveillance data-set with data on mobility and testing, we develop a deterministic compartment model
aimed at performing a retrospective analysis to understand the main modifications occurred to the characteristic parameters that regulate the epidemic spreading. We find that, besides self-protective behaviors, a reduction of susceptibility should have occurred
in order to explain the fast descent of the epidemic after the peak. A sensitivity analysis of the basic reproduction number, in response to variations of the epidemiological parameters that can be influenced by policy-makers, shows the primary importance
of a rigid isolation procedure for the diagnosed cases, combined with an intensive effort in performing extended testing campaigns. Future scenarios depend on the ability to protect the population from the injection of new cases from abroad, and to pursue
in applying rigid self-protective measures. |
|
Roy, MP |
European review for medical and pharmacological sciences |
Epidemiology| Épidémiologie |
Weather parameters may have some role in determining the spread of Coronavirus disease 2019. Daily data on COVID-19
from Pune, India were collected from 17th May to 4th July 2020 and analyzed with such parameters. Relative humidity was found to have a positive relationship with the number of daily cases, even after taking a lag period of one week. Further studies may be
helpful in understanding such relationships. © 2020 Verduci Editore s.r.l. All rights reserved. |
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|
Ruffin, Manon, Bigot, et al |
bioRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
This study shows that the main component of P. aeruginosa flagella, ie. flagellin is able to increase TMPRSS2 expression
in Airway epithelial cells (AEC), and even more in those deficient for CFTR gene. Importantly, this increased TMPRSS2 expression is associated with an increase in the level of SARS-CoV-2 infection. This result is of major significance for patients with cystic
fibrosis (CF) which are frequently infected and colonized by P. aeruginosa during the course of the disease. |
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COVID-19 mimicking dengue fever with the initial manifestation of retro-orbital
pain – A Rare Case |
Ruiy, W, Hsu, et al |
Journal of the Formosan Medical Association |
Clinical data| Données cliniques |
Herein, we report a rare case of a 62-year-old Taiwanese female initially presenting retro-orbital pain with fever,
mimicking Dengue fever. The patient was quickly identified to have been infected by SARS-CoV-2 and was hospitalized on March 15, 2020. |
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Analytical assessment of Beckman Coulter Access anti-SARS-CoV-2
IgG immunoassay |
Ruscio, Maurizio, Agnolo, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Evaluated the analytical performance of the novel Beckman Coulter anti-SARS-CoV-2 IgG chemiluminescent immunoassay.
Intra-assay, inter-assay and total imprecision of Beckman Coulter anti-SARS-CoV-2 IgG were between 4.3-4.8%, 2.3-3.9% and 4.9-6.2%, respectively. The linearity of the assay was excellent between 0.11-18.8 antibody titers. The LOB, LOD and functional sensitivity
were 0.02, 0.02 and 0.05, respectively. The diagnostic accuracy (area under the curve; AUC) of Beckman Coulter anti-SARS-CoV-2 IgG compared to molecular testing was 0.87 using manufacturer's cut-off, and increased to 0.90 with antibody titers. The AUC was
non-significantly different from that of Roche Elecsys Anti-SARS-CoV-2, but was always higher than that of DiaSorin Liaison SARS-CoV-2 S1/S2 IgG. The correlation of Beckman Coulter Access SARS-CoV-2 IgG was 0.80 with Roche Elecsys Anti-SARS-CoV-2 and 0.72
with DiaSorin Liaison SARS-CoV-2 S1/S2 IgG, respectively. |
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COVID-19 in cancer patients: clinical characteristics and outcome-an analysis of
the LEOSS registry |
Rüthrich, MM, Giessen-Jung, et al |
Ann Hematol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Here, we present an analysis of cancer patients from the LEOSS (Lean European Open Survey on SARS-CoV-2 Infected Patients)
registry to determine whether cancer patients are at higher risk. omparing cancer and non-cancer patients, outcome of COVID-19 was comparable after adjusting for age, sex, and comorbidity. However, our results emphasize that cancer patients as a group are
at higher risk due to advanced age and pre-existing conditions. |
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Safari, I, InanlooRahatloo, et al |
Journal of medical virology |
Coronavirology| Coronavirologie |
We analyzed 2790 SARS‐CoV‐2 genome sequences from 56 countries that were available on April 2, 2020, to assess the
evolution of the virus during this early phase of its expansion. We aimed to assess sequence variations that had evolved in virus genomes, giving the greatest attention to the S gene. Our most important findings relate to haplotypes. Sixty‐six haplotypes that
constitute thirteen haplotype groups (H1–H13) were identified, and 84.6% of the 2790 sequences analyzed were associated with these haplotypes. |
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Transport of awake hypoxemic probable COVID 19 patients in the prone position |
Şan, İ, Yıldırım, et al |
American Journal of Emergency Medicine |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We aimed to investigate the effects of transport with prone position on hypoxemia in hypoxemic and awake probable COVID
19 pneumonia patients. It was found that pO2 and SpO2 end values were statistically significantly higher in the patient group compared to the initial values. In the group with transport duration of more than 15 min, a difference was found between the initial
and end values in pO2 and SpO2 parameters similar to the whole group. However, there was no statistically significant difference between the initial and end values in the group with transport duration of 15 min or below. |
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3D-printed simulator for nasopharyngeal swab collection for COVID-19 |
Sananès, N, Lodi, et al |
Eur Arch Otorhinolaryngol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The objective of this study was to develop a realistic and easily available synthetic simulator for nasopharyngeal
swab collection. Authors developed a nasopharyngeal swab collection simulator which can be produced by 3D printing via an open access link, which offers complete operating instructions. |
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Sanchez-Betancourt, A, Sibaja-Alvarez, et al |
Surg Case Rep |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We look to describe the first case of a COVID-19 patient that required surgical management in Costa Rica and present
a summary of the protection measures utilized in a tertiary care hospital. We present the case of a 29 year old obese male who had acute appendicitis with perforation that contracted SARS-CoV-2, who later required multiple surgeries to address an infected
abdominal hematoma both while having an active COVID-19 infection and afterwards. The successful management of this patient is the first experience in Costa Rica on how to properly address staff safety during a surgical procedure. None of the workers involved
in care of this patient were diagnosed with SARS-CoV-2. |
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Santana-Cibrian, M, Acuna-Zegarra, et al |
Mathematical Biosciences and Engineering |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this paper, we use a mathematical model to characterize the impact of short duration transmission events within
the confinement period previous but close to the epidemic peak. The model also describes the possible consequences on the disease dynamics after mitigation measures are lifted. We use Mexico City as a case study. The results show that events of high mobility
may produce either a later higher peak, a long plateau with relatively constant but high incidence or the same peak as in the original baseline epidemic curve, but with a post-peak interval of slower decay. |
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Epileptiform activity and seizures in patients with COVID-19 |
Santos de Lima, F, Issa, et al |
J Neurol Neurosurg Psychiatry |
Clinical data| Données cliniques |
The aims of this study were to determine the prevalence of epileptiform activity and to assess the risk of seizures
in patients with COVID-19. Between 1 March and 27 May 2020 in the University of Chicago Hospital, routine or continuous video–EEG monitoring was reported for 32 COVID-19 patients. Acute symptomatic seizures were observed clinically in 4 of 32 (12.5%) patients.
That 18.8% of patients studied with EEG in the study period had interictal and ictal EEG patterns highlights the risk of seizures in patients with COVID-19. |
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Locked-in Syndrome in a Young Patient Due to SARS-CoV-2: A Case Report |
Sattar, SBA, Iqbal, et al |
Frontiers in Medicine |
Clinical data| Données cliniques |
Coronavirus disease 2019 (COVID-19), apart from commonly involving the respiratory system, has its impact on the central
nervous system, with a wide spectrum of clinical presentations ranging from headaches to ischemic strokes. The ongoing research regarding this novel disease has found that there is a very high prevalence of thrombotic episodes especially in critically ill
patients when compared to severe presentation of other viral illnesses. This COVID-19-associated coagulopathy has a very complex etiology with the ability to form thrombus in arteries, veins, and microvasculatures of different organs. We present a unique case
of a young woman with underlying COVID-19 who unfortunately developed locked-in syndrome due to bilateral pontine infarction during the course of her illness. © Copyright © 2020 Sattar, Iqbal, Haider, Zia, Niazi, Hanif, Ali and Khan. |
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Scherf-Clavel, Oliver, Kaczmarek, et al |
bioRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique Animal model | Modèle
animal |
This study chose an adapted mouse model to demonstrate its suitability to provide sufficient information on the model
substances GS-441 524 and HCQ regarding plasma concentration and distribution into relevant tissues a prerequisite for treatment effectiveness. High tissue to plasma ratios for GS-441 524 and HCQ were found, indicating a significant distribution into the examined
tissue, except for the central nervous system and fat. For GS-441 524, measured tissue concentrations exceeded the reported in vitro EC50 values by more than 10-fold and in consideration of its high efficacy against feline infectious peritonitis, GS-441 524
could indeed be effective against SARS-CoV-2 in vivo. For HCQ, relatively high in vitro EC50 values are reported, which were not reached in all tissues. Facing its slow tissue distribution, HCQ might not lead to sufficient tissue saturation for a reliable
antiviral effect. |
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Schinköthe, J, Scheinemann, et al |
Appl Environ Microbiol |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
We used quantitative carrier testing (QCT) procedures to compare the sensitivity of commercial spore carriers (CSC)
with that of surrogates for non-enveloped and enveloped viruses including SARS-CoV-2, mycobacteria, and spores to an aerosolized mixture of peroxyacetic acid and hydrogen peroxide (aPAA/HP). Overall, we conclude that dry fogging a mixture of aPAA/HP is highly
efficient against a broad range of microorganisms as well as material compatible with relevant concentrations. We show that dry fogging a mixture of aPAA/HP is highly microbicidal, efficient, fast, robust, environmentally neutral, and a suitable airborne disinfection
method. In addition, the low concentration of dispersed disinfectant, particularly for enveloped viral pathogens like SARS-CoV-2, entails high material compatibility. For these reasons and due to the relative simplicity of the procedure, it is an ideal disinfection
method for hospital wards, ambulances, public conveyances and indoor community areas. Thus, we conclude that this method is an excellent choice for control of the current SARS-CoV-2 pandemic. |
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|
Schmitz, D, Vos, et al |
Eur J Emerg Med |
Epidemiology| Épidémiologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé |
The aim of this study was to investigate the association between PPE use and SARS-CoV-2 infections among ED personnel
in the Netherlands. In this cross-sectional study, the use of high-level PPE (FFP2 or equivalent and eye protection) by ED personnel during all contacts with patients with suspected or confirmed SARS-CoV-2 does not seem to be associated with a lower infection
rate of ED staff compared to lower level PPE use. |
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Schwarz, S, Jenetzky, et al |
Monatsschrift fur Kinderheilkunde |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The authors initiated a central recording of case numbers, individual case descriptions and observations on infections
and illnesses with SARS-CoV‑2 (www.co-ki.de). 557 pediatricians have participated. Together they care for ca. 670,000 children. They reported 9803 children who presented as suspected cases. The pediatricians themselves had a clinical suspicion of SARS-CoV‑2
infections in 3654 children. In 7707 children PCR tests were carried out using nose/throat swabs of which 198 (2.6%) were positive. In addition, 731 children were tested for SARS-CoV‑2 antibodies with detection in 82 cases (11.2%). Despite initially positive
PCR tests, 47 children had a negative antibody test at least 2 weeks later. Our query as to infections of adults by children yielded only one case, which a telephone enquiry revealed as unlikely. |
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|
Seadawy, Mohamed Gomaa, Gad, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study tested the natural flavonoids, Terpenoid and Thymoquinone against different viral and host-cell protein
targets. Molecular docking combined with cytotoxicity and plaque reduction assay is used to test the natural compounds against different viral (Spike, RdRp, and Mpro) and host-cell (TMPRSS II, keap 1, and ACE2) targets. The results demonstrate the binding
possibility of the natural compounds (Thymol, Carvacrol, Hesperidine, and Thymoquinone) to the viral main protease (Mpro). |
|
|
Selingerova, I, Valik, et al |
Journal of medical virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here we show that (i) high‐level IgM specimens need to be diluted with negative human plasma but not kit diluents and
(ii) measured anti‐SARS‐CoV‐2 IgM/IgG concentrations are substantially higher with later marketed immunoassay batch leading to (iii) the change of qualitative interpretation (positive vs. negative) in 12.3% of specimens measured for IgM, (iv) the informative
time‐course pattern of antibody production only when data from different immunoassay batches are not combined. |
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|
Shalimar, Vaishnav, M, et al |
Journal of Clinical and Experimental Hepatology |
Clinical data| Données cliniques |
We aimed to study the outcomes of conservative treatment for gastrointestinal (GI) bleeding in patients with COVID-19.
In this retrospective analysis, 24 of 1342 (1.8%) patients with COVID-19, presenting with GI bleeding from 22nd April to 22nd July 2020, were included. Conservative management strategies including pharmacotherapy, restrictive transfusion strategy, and close
hemodynamic monitoring can successfully manage GI bleeding in COVID-19 patients and reduce need for urgent endoscopy. Three (12.5%) cirrhosis patients succumbed to acute hypoxemic respiratory failure during hospital stay. |
|
|
Shao, S, Zhao, et al |
Medicine (Baltimore) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Identified risk factors that could be associated with severe type of COVID-19 from common type. A total of 126 patients
were recruited from January 23 to March 23, 2020. Ninety cases were identified as the common type and 36 as the severe type. The average age in the severe group was significantly older than that in the common group. Patients with severe COVID-19 exhibited
higher proportions of dyspnea, weakness, and diarrhea. Moreover, there were more patients with hypertension or coinfection in the severe group than in the common group. Additionally, severe COVID-19 was associated with increased neutrophil counts, C-reactive
protein, procalcitonin and decreased lymphocyte counts, hemoglobin, total protein (TP), and albumin (ALB). Based on logistic regression analysis, dyspnea, TP, and ALB were independent risk factors for severe disease. |
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Sharma, GD, Ghura, et al |
Frontiers in Psychology |
Mental Health |
|
We conducted semi-structured interviews on 59 subjects from India to investigate the impact of information, misinfodemics
(spread of wrong information), and isolation on their psychology. Our findings reveal that flow of information leads to anxiety, caution, and knowledge; while misinfodemics cause panic, distrust, and confusion; and isolation creates cognitive dissonance (the
state of having inconsistent thoughts, beliefs, or attitudes) and adaptability among masses. The encouraging part of our findings is that, as of now, the situation is far from the state of depression. |
|
|
Shekaari, A, Jafari, et al |
J Mol Struct |
Coronavirology| Coronavirologie |
We have carried out an in silico investigation on the COVID-19 main protease (M(pro)) via applying finite-temperature
all-atom molecular dynamics simulations. An exponentially decaying brand of behavior has been found for the calculated echo depth values with increasing time, which has accordingly led to a much small dephasing time of about 150 fs, revealing a significant
anharmonicity and therefore an overall structural stiffness for the COVID-19 main protease. |
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Dysosmia and dysgeusia in patients with COVID-19 in northern Taiwan |
Sheng, WH, Liu, et al |
Journal of the Formosan Medical Association |
Clinical data| Données cliniques |
We investigate the characteristics of dysosmia and dysgeusia among patients diagnosed with coronavirus disease 2019
(COVID-19) in Taiwan. Dysosmia and/or dysgeusia are common symptoms and clues for the diagnosis of COVID-19, particularly in the early stage of the disease. Physicians should be alerted to these symptoms to make timely diagnosis and management for COVID-19
to limit spread. |
|
Sherina, Natalia, Piralla, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
This cohort study profiled the serum anti-SARS-CoV-2 antibody levels and virus specific memory B- and T-cell responses
over time in convalescent COVID-19 patients. Anti-SARS-CoV-2 antibodies were present in 85% samples collected within 4 weeks after onset of symptoms in COVID-19 patients. Levels of specific IgM or IgA antibodies declined after 1 month while levels of specific
IgG antibodies remained stable up to 6 months after diagnosis. Anti-SARS-CoV-2 IgG antibodies were still present, though at a significantly lower level, in 80% samples collected at 6-8 months after symptom onset. SARS-CoV-2-specific memory B- and T-cell responses
were developed in vast majority of the patients tested, regardless of disease severity, and remained detectable up to 6-8 months after infection. Although the serum levels of anti-SARS-CoV-2 IgG antibodies started to decline, virus-specific T and/or memory
B cell responses increased with time and maintained during the study period (6-8 months after infection). |
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The differential mental health impact of COVID-19 in Arab countries |
Shuwiekh, HAM, Kira, et al |
Current Psychology |
Mental Health |
|
A questionnaire including measures of COVID-19 traumatic stress, PTSD, depression, anxiety, and cumulative stressors
and trauma was distributed anonymously online in seven Arab countries (Egypt (N = 255), Kuwait (N = 442), Jordan (N = 216), Saudi Arabia (N = 212, Algeria (N = 110), Iraq and Palestine (N = 139)). The ANOVA results indicated that the differences in COVID19
traumatic stress, PTSD, depression, and anxiety between the countries were significant. Post-hoc analysis indicated that Egypt is significantly higher than all the other Arab countries in COVID-19 traumatic stress, PTSD, anxiety, and depression. Stepwise regression
indicated that COVID-19 traumatic stress accounted for significant variance above and beyond the variance accounted for by previous cumulative stressors and traumas for anxiety in all countries and PTSD and depression in all countries except for Algeria. |
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Evaluation of SARS-CoV-2 PCR Positive Cases in the Pediatric Emergency Department |
Şık, N, Özlü, et al |
Mikrobiyoloji bulteni |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The objective of the study was to evaluate the epidemiological, clinical, laboratory and radiologic findings, treatment
and clinical outcomes of patients admitted to the pediatric emergency department with the suspicion of COVID-19. Between March 11 and June 16, 2020, patients aged between 1 month-18 years admitted to the pediatric emergency department and who have an indication
for sampling for the polymerase chain reaction (PCR) method with the suspicion of COVID-19. The demographic characteristics, symptoms, durations and the history of contact with the suspected/definite COVID-19 cases were questioned in the patients with positive
results. Physical examination, laboratory and imaging data of the patients were recorded. According to clinical severity, patients were divided into five groups. Treatment methods, ward/intensive care unit admission, length of stay at hospital, and prognosis
were recorded. Of the 237 patients included in the study, 45 (18.9%) of the samples were positive and 192 (81.1%) were negative. There was a history of contact with COVID-19 positive case in 38 (85.6%) of COVID-19 PCR positive patients. The mean time for onset
of symptoms after contact was 3.5 ± 1.7 days. Twenty-one of the patients (46.6%) were asymptomatic and the most common symptom was fever (34.1%) and cough (27.3%). Of the patients whose laboratory tests were requested, lymphopenia was detected in 50% and 52.3%
of procalcitonin, 23.5% of C-reactive protein and 64.7% of D-dimer values were found to be high. Chest radiography was obtained from 45.4% of the patients; 90.0% were evaluated as normal, bronchovascular change, pleural effusion and consolidation were detected
in one of each (5.0%) patient. Thorax computed tomography (CT) was obtained from 4 (9.0%) patients. One patient had normal CT findings, two patients had consolidation, one patient had peripheral ground-glass appearance and one patient had pleural effusion.
Antibiotics were started in 38.6% of the patients and the most commonly used antibiotic was azithromycin (34.1%). Oseltamivir was started in one (2.3%) patient, and 10 (24.7%) patients were treated with hydroxychloroquine. There were no serious and critical
cases according to the clinical severity. |
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Does having a high-risk pregnancy influence anxiety level during the COVID-19
pandemic? |
Sinaci, S, Ozden Tokalioglu, et al |
European Journal of Obstetrics and Gynecology and Reproductive Biology |
Mental Health |
|
Authors aimed to analyze the changing level of anxiety during COVID-19 pandemic in pregnant women, with and without
high-risk indicators separately, in a tertiary care center serving also for COVID-19 patients, in the capital of Turkey. High-risk pregnant women require routine anxiety and depression screening and psychosocial support during the COVID-19 pandemic. |
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Exponentiated transformation of Gumbel Type-II distribution for modeling COVID-19
data |
Sindhu, TN, Shafiq, et al |
Alexandria Engineering Journal |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The aim of this study is to analyze the number of deaths due to COVID-19 for Europe and China. For this purpose, we
proposed a novel three parametric model named as Exponentiated transformation of Gumbel Type-II (ETGT-II) for modeling the two data sets of death cases due to COVID-19. To examine efficiency of the ETGT-II model a simulation analysis is performed. Finally,
using the data sets of death cases of COVID-19 of Europe and China to show adaptability of suggested model. The results reveal that it may fit better than other well-known models. |
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Case Reports of Cerebral Sinus Venous Thrombosis in COVID-19 Patients |
Sitanggang, Prysta Aderlia, Tini, et al |
Research Square prepub |
Clinical data| Données cliniques Long-Term Sequelae |
|
Report two cases of cerebral sinus venous thrombosis in COVID-19 patients following the respiratory manifestations
with profound haematological and coagulation disarrangement triggered by COVID-19 and these are assumed as underlying mechanism |
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Skrip, L, Derra, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Countries within the sub-Saharan Africa (SSA) region may experience high COVID-19 case fatality rates. Over the first
months of the epidemic in SSA, deceased cases have tended to mainly be male, aged >50 years and have underlying comorbidities. Delayed or no care-seeking was prevalent among deceased COVID-19 cases in Burkina Faso. Analysis on a synthetic case population suggested
that treatment with oxygen therapy or convalescent plasma reduced the adjusted odds of COVID-19 mortality. Low-cost, scalable and sustainable strategies for COVID-19 case management in the SSA context warrant attention and investment to reduce disparity in
case fatality. |
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Aerosol persistence in relation to possible transmission of SARS-CoV-2 |
Smith, SH, Somsen, et al |
Physics of Fluids |
Modelling/ prediction| Modélisation/prédiction Transmission |
By measuring and modeling the dynamics of exhaled respiratory droplets, we can assess the relative contribution of
aerosols to the spreading of SARS-CoV-2. We measure size distribution, total numbers, and volumes of respiratory droplets, including aerosols, by speaking and coughing from healthy subjects. Dynamic modeling of exhaled respiratory droplets allows us to account
for aerosol persistence times in confined public spaces. The probability of infection by inhalation of aerosols when breathing in the same space can then be estimated using current estimates of viral load and infectivity of SARS-CoV-2. The current known reproduction
numbers show a lower infectivity of SARS-CoV-2 compared to, for instance, measles, which is known to be efficiently transmitted through the air. In line with this, our study of transmission of SARS-CoV-2 suggests that aerosol transmission is a possible but
perhaps not a very efficient route, in particular from non-symptomatic or mildly symptomatic individuals that exhibit low viral loads. |
|
Soin, AS, Choudhary, et al |
Journal of Clinical and Experimental Hepatology |
Healthcare Response | Réponse des soins de santé |
The impact of COVID-19 on living-donor liver transplantation (LDLT) activity and outcome is not known. We performed
LDLT only for sick patients or patients with advanced hepatocellular carcinoma in this period, with special COVID protocols. LDLT activity substantially reduced during the COVID era. The incidence and outcome of COVID-19 among the waiting or transplanted patients
and HCWs were similar to those of the general population. The outcome after LDLT in the COVID era was similar to that in non-COVID times. These data suggest that LDLT may be extended to more stable patients with strict protocols. |
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|
Soreide, K, Yaqub, et al |
Ann Surg |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
To model the risk of admitting silent COVID-19-infected patients to surgery with subsequent risk of severe pulmonary
complications and mortality. The model highlights a considerable risk of admitting patients with silent COVID-19 to surgery with an associated risk for adverse perioperative outcomes and deaths. Strategies to avoid excessive complications and deaths after
surgery during the pandemic are needed. |
|
|
Spaccarotella, C, Migliarino, et al |
J Cardiovasc Med (Hagerstown) |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Although in the pandemic period the treatment in the cath laboratory of high-risk ACS should not be delayed because
the operators wear special protection systems, the subsequent risk of contagion in a non-Covid coronary care unit could be high in the case of patients positive for SARS-CoV-2. We tested the possibility of a fast-track protocol in 51 consecutive patients (mean
age 65 ± 12 years) transferred from spokes centres or from the field to our HUB centre and admitted to our coronary care unit (CCU). Once the patient had arrived in the cath lab, the nasopharyngeal swab was performed. The real-time PCR to extract RNA for SARS-CoV-2
detection was performed with an automated rapid molecular Xpert Xpress test. Meanwhile, coronary angiography or percutaneous coronary intervention was performed if necessary. This study demonstrates that 0–1.5 h fast-track triage for coronavirus disease 2019
(COVID 19) is feasible in patients with ACS. The execution of nasopharyngeal swab in the cath lab and its analysis with a rapid molecular test allows rapid stratification of SARS-CoV-2 infection. |
|
|
Srivastava, S, Verma, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
A novel reverse epitomics approach, ‘overlapping-epitope-clusters-to-patches’ method is utilized to identify the antigenic
regions from the SARS-CoV-2 proteome. These antigenic regions are named as ‘Ag-Patch or Ag-Patches’, for Antigenic Patch or Patches. The identification of Ag-Patches is based on the clusters of overlapping epitopes rising from SARS-CoV-2 proteins. We identified
73 CTL (Cytotoxic T-Lymphocyte) and 49 HTL (Helper T-Lymphocyte) novel Ag-Patches from the proteome of SARS-CoV-2. Further, we have utilized the identified Ag-Patches to design Multi-Patch Vaccines (MPVs), proposing a novel method for the vaccine design.
We conclude that the novel MPVs could be a highly potential novel approach to combat SARS-CoV-2, with greater effectiveness, high specificity and large human population coverage worldwide. |
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|
Steenwyk, JacobL, Mead, et al |
bioRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
This study analyzed the genomes and characterized the phenotypic profiles of four COVID-19 associated pulmonary aspergillosis
(CAPA) isolates obtained from patients treated in Germany to gain insight into CAPA. Found that CAPA isolate genomes do not exhibit major differences from the genome of the Af293 reference strain. By examining virulence in an invertebrate moth model, growth
in the presence of osmotic, cell wall, and oxidative stressors, and the minimum inhibitory concentration of antifungal drugs, found that CAPA isolates were generally, but not always, similar to A. fumigatus reference strains Af293 and CEA17. Notably, CAPA
isolate D had more putative loss of function mutations in genes known to increase virulence when deleted (e.g., in the FLEA gene, which encodes a lectin recognized by macrophages). Moreover, CAPA isolate D was significantly more virulent than the other three
CAPA isolates and the A. fumigatus reference strains tested. |
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|
Stoddard, Madison, Johnson, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique |
Evaluated a model-based examination of the USS Theodore Roosevelt outbreak to understand the dynamics of COVID-19 spread
aboard the aircraft carrier. We have used a series of counterfactual "what-if" analyses to better understand the options available to public health authorities in such situations. The models suggest that rapid mass evacuation and widespread surveillance testing
can be effective in these settings. Our results lead to a set of generalizable recommendations for disease control that are broadly applicable to the current COVID-19 crisis as well as to future pandemics. |
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|
Strömich, Léonie, Wu, et al |
bioRxiv |
Coronavirology| Coronavirologie |
This study reports the allosteric communication pathways in the main protease dimer by using two novel fully atomistic
graph theoretical methods: Bond-to-bond propensity analysis, which has been previously successful in identifying allosteric sites without a priori knowledge in benchmark data sets, and, Markov transient analysis, which has previously aided in finding novel
drug targets in catalytic protein families. We further score the highest ranking sites against random sites in similar distances through statistical bootstrapping and identify four statistically significant putative allosteric sites as good candidates for
alternative drug targeting. |
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Predicting COVID-19 Disease Progression and Patient Outcomes based on Temporal
Deep Learning |
Sun, Chenxi, Hong, et al |
Research Square prepub |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This aim of this study was to develop clear COVID-19 stage definition. We found 4 stages of COVID-19 progression with
different patient statuses and mortality risks. Predicting which of the 4 stages the patient is currently in can help doctors better assess and cure the patient. |
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Acute gastrointestinal injury in critically ill patients with COVID-19 in Wuhan,
China |
Sun, JK, Liu, et al |
World Journal of Gastroenterology |
Clinical data| Données cliniques |
This retrospective study investigated the prevalence and outcomes of acute gastrointestinal injury (AGI) in 83 critically
ill patients with COVID-19. Demographic data, laboratory parameters, AGI grades, clinical severity and outcomes were collected. The primary endpoints were AGI incidence and 28-d mortality. The incidence of AGI was 86.7%, and hospital mortality was 48.2% in
critically ill patients with COVID-19. Sequential organ failure assessment (SOFA) scores, white blood cell counts, and duration of mechanical ventilation were risk factors for the development of AGI grade II and above. Patients with worse AGI grades had a
higher incidence of septic shock and 28-d mortality. |
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Discovery of Cyclic Sulfonamide derivatives as Potent Inhibitors of SARS-CoV-2 |
Sup Shin, Y, Young Lee, et al |
Bioorg Med Chem Lett |
Therapeutics| Thérapeutique Immunology | Immunologie |
This study identified a class of cyclic sulfonamide derivatives as novel SARS-CoV-2 inhibitors. Compound 13c of the
synthesized compounds exhibited robust inhibitory activity (IC(50) = 0.88 μM) against SARS-CoV-2 without cytotoxicity (CC(50) > 25 μM), with a selectivity index (SI) of 30.7. In addition, compound 13c exhibited high oral bioavailability (77%) and metabolic
stability with good safety profiles in hERG and cytotoxicity studies. The present study identified that cyclic sulfonamide derivatives are a promising new template for the development of anti-SARS-CoV-2 agents. |
|
Taresh, Mundher, Zhu, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Explored the effectiveness of artificial intelligence (AI) in the rapid and reliable detection of COVID-19 based on
chest X-ray imaging. In this study, reliable pre-trained deep learning algorithms were applied to achieve the automatic detection of COVID-19-induced pneumonia from digital chest X-ray images. Moreover, the study aims to evaluate the performance of advanced
neural architectures proposed for the classification of medical images over recent years. The data set used in the experiments involves 274 COVID-19 cases, 380 viral pneumonia, and 380 healthy cases, which was collected from the available X-ray images on public
medical repositories. The confusion matrix provided a basis for testing the post classification model. Furthermore, an open-source library PyCM* was used to support the statistical parameters. The study revealed the superiority of Model VGG16 over other models
applied to conduct this research where the model performed best in terms of overall scores and based-class scores. According to the research results, deep learning with X-ray imaging is useful in the collection of critical biological markers associated with
COVID-19 infection. The technique is conducive for the physicians to make a diagnosis of COVID-19 infection. Meanwhile, the high accuracy of this computer-aided diagnostic tool can significantly improve the speed and accuracy of COVID-19 diagnosis. |
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Evaluation of Job Strain of Family Physicians in COVID-19 Pandemic Period-
An Example from Turkey |
Taş, Beray Gelmez, Özceylan, et al |
Research Square prepub |
Mental Health |
|
The purpose of this study was to evaluate family physicians' job strain in Istanbul during the Covid-19 pandemic and
determine the effective factors .In the pandemic process, anxiety, sleep quality deterioration and job strain increased significantly. |
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Worry, avoidance, and coping during the COVID-19 pandemic: A comprehensive network
analysis |
Taylor, S, Landry, et al |
Journal of anxiety disorders |
Public Health response| Interventions de santé publique |
Many psychological factors play a role in the COVID-19 pandemic, including various forms of worry, avoidance, and coping.
A population-representative sample of 3075 American and Canadian adults completed an online survey, including measures of COVID-19-related worry, avoidance, self-protective behaviors, and other variables. Network analysis showed how how these diverse elements
are interrelated. The network consisted of three major hubs: worries about the dangerousness of COVID-19, belief that the COVID-19 threat is exaggerated, and complusive checking and reassurance-seeking. |
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Taylor, S, Landry, et al |
Frontiers in Psychology |
Vaccine Research| Recherche sur les vaccins Public Health response| Interventions de
santé publique |
The objectives of this study were to investigate the prevalence of vaccination hesitancy for a SARS-CoV2 vaccine, the
motivational roots of this hesitancy, and the most promising incentives for improving the likelihood of vaccination uptake when a vaccine does become available in a cross-sectional sample of 3,674. Many American (25%) and Canadian (20%) respondents said that
they would not get vaccinated against SARS-CoV2 if a vaccine was available. Non-adherence rates of this magnitude would make it difficult or impossible to achieve herd immunity. Vaccine rejection was most strongly correlated with mistrust of vaccine benefit,
and also correlated with worry about unforeseen future effects, concerns about commercial profiteering from pharmaceutical companies, and preferences for natural immunity. When asked about incentives for getting vaccinated, respondents were most likely to
report that evidence for rigorous testing and safety of the vaccine were of greatest importance. |
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Tembhre, MK, Parihar, et al |
Br J Dermatol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We determined the status of major determinants of SARS-CoV-2 infection i.e. ACE2 and TMPRSS2 in the peripheral blood
and skin of psoriasis. We recruited n=40 psoriasis patients and n=40 controls and blood samples were collected from both groups. Skin biopsy samples were collected from lesional skin of psoriasis patients and control group. Transcript levels
of ACE2 were significantly increased in peripheral blood and lesional skin of psoriasis patients compared to controls but no significant difference was observed for TMPRSS2 |
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GM-CSF Neutralization With Lenzilumab in Severe COVID-19 Pneumonia: A Case-Cohort
Study |
Temesgen, Z, Assi, et al |
Mayo Clinic proceedings |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We assess the efficacy and safety of lenzilumab in patients with severe coronavirus disease 2019 (COVID-19) pneumonia.
Twelve patients were treated with lenzilumab; 27 patients comprised the matched control cohort (untreated). Clinical improvement, defined as improvement of at least 2 points on the 8-point ordinal clinical endpoints scale, was observed in 11 of 12 (91.7%)
patients treated with lenzilumab and 22 of 27 (81.5%) untreated patients. |
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Olfactory taste disorder as a presenting symptom of COVID-19: a large single-center
Singapore study |
Tham, AC, Thein, et al |
Eur Arch Otorhinolaryngol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Authors investigate the prevalence and epidemiological risk factors of olfactory and/or taste disorder (OTD), in particular
isolated OTD, in patients with laboratory-confirmed COVID-19 infection. Patients with COVID-19 infection can present with OTD, either in isolation or in combination with other general symptoms. |
|
Thiel, SL, Weber, et al |
Swiss medical weekly |
Epidemiology| Épidémiologie |
To characterise the COVID-19 pandemic in Liechtenstein. During the first wave, 5% of the population obtained a reverse
transcriptase polymerase chain reaction test. A total of 95 patients (median age 39 years) were diagnosed with COVID-19 (82 who resided in Liechtenstein), resulting in an incidence in Liechtenstein of 0.211%. One patient, aged 94, died (mortality rate 1%).
Testing the patients’ household and close workplace contacts (n = 170) with antibody tests revealed that 25% of those tested were additional COVID-19 cases, a quarter of whom were asymptomatic. Those households which adhered to strict isolation measures had
a significantly lower rate of affected household members than those who didn’t follow such measures. A multitude of factors (e.g., young age of the patients, low-threshold access to testing, close monitoring of cases, high alertness and adherence to public
health measures by the population) led to the early containment of the first wave of the pandemic, with a very low rate of serious outcomes. Antibody testing for SARS-CoV-2 revealed a substantial proportion of undiagnosed COVID-19 cases among close contacts
of the patients. |
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The structure of the membrane protein of sars-cov-2 resembles
the sugar transporter semisweet |
Thomas, S |
Pathogens and Immunity |
Coronavirology| Coronavirologie |
The structure and function of the most abundant structural protein of SARS-CoV-2, the membrane (M) glycoprotein, is
not fully understood. Using in silico analyses we determined the structure and potential function of the M protein. The M protein of SARS-CoV-2 is 98.6% similar to the M protein of bat SARS-CoV, main-tains 98.2% homology with pangolin SARS-CoV, and has 90%
homology with the M protein of SARS-CoV; whereas, the similarity is only 38% with the M protein of MERS-CoV. In silico analyses showed that the M protein of SARS-CoV-2 has a triple helix bundle, forms a single 3-trans-membrane domain, and is homologous to
the prokaryotic sugar transport protein SemiSWEET. SemiSWEETs are related to the PQ-loop family whose members function as cargo receptors in vesicle transport, mediate movement of basic amino acids across lysosomal membranes, and are also involved in phospholipase
flippase function. The advantage and role of the M protein having a sugar transporter-like structure is not clearly understood. |
|
Tincati, C, Cannizzo, et al |
Frontiers in Immunology |
Immunology | Immunologie |
In this study authors reasoned that the immune events occurring at the turning point of disease might mark the direction
toward pathogenic versus protective inflammatory responses. Observations suggest Th1 polarization coupled to higher cytolytic profile in sCovid-19 as correlate of disease pathogenesis and as potential targets to be investigated in the roadmap to therapy and
vaccine development. |
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Tofigh, AM, Shojaei, et al |
Journal of Cellular and Molecular Anesthesia |
Clinical data| Données cliniques |
We present seven cases of COVID-19 patients with pneumothorax as one of the ominous side effects of the disease and
a strong predictor of death which is a new challenge in controlling the transmission and distribution of the disease. |
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Trentini, Filippo, Marziano, et al |
medRxiv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Evaluate the effect of healthcare strain on ICU admission and survival. 43,538 patients were admitted to a hospital
in the region between February 20 and July 12, 2020, of which 3,993 (9.2%) were admitted to an ICU. During the period of highest hospital strain (March 16 - April 22), individuals older than 70 years had a significantly lower probability of being admitted
to an ICU and significantly longer times between hospital and ICU admission, indicating elective admission due to constrained resources. Healthcare strain did not have a clear effect on mortality, with the overall proportion of deaths declining from 52.1%
for ICU patients admitted to the hospital before March 16, to 43.4% between March 16 and April 22, to 27.6% after April 22. |
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Tsai, Shang-Jui, Guo, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins Animal model | Modèle animal |
This study describes a different approach to SARS-CoV-2 vaccine development that uses exosomes to deliver mRNAs that
encode antigens from multiple SARS-CoV-2 structural proteins. Immunized mice developed CD4+, and CD8+ T-cell reactivities that respond to both the SARS-CoV-2 nucelocapsid protein and the SARS-CoV-2 spike protein. These responses were apparent nearly two months
after the conclusion of vaccination, as expected for a durable response to vaccination. In addition, the spike-reactive CD4+ T-cells response was associated with elevated expression of interferon gamma, indicative of a Th1 response, and a lesser induction
of interleukin 4, a Th2-associated cytokine. Vaccinated mice showed no sign of altered growth, injection-site hypersensitivity, change in white blood cell profiles, or alterations in organ morphology. Consistent with these results, we also detected moderate
but sustained anti-nucleocapsid and anti-spike antibodies in the plasma of vaccinated animals. |
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Usefulness of Lung Ultrasound Follow-up in Patients Who Have Recovered From Coronavirus
Disease 2019 |
Tung-Chen, Y, Martí de Gracia, et al |
J Ultrasound Med |
Long-Term Sequelae |
|
We describe 3 recovered patients who had coronavirus disease 2019, with long-persisting symptoms (remarkable muscle
weakness and dyspnea on exertion) after recovery, in whom chest computed tomographic and concurrent lung ultrasound examinations were performed. |
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Turkington, R, Mulvenna, et al |
JMIR Ment Health |
Mental Health |
|
The objective of this study was to determine whether the COVID-19 pandemic has had any influence on the calls made
to Samaritans Ireland, a national crisis helpline within the Republic of Ireland. Statistical differences were observed in caller behavior between the prelockdown and active lockdown periods. The findings suggest that service users relied on crisis helpline
services more during the lockdown period due to an increased sense of isolation, worsening of underlying mental illness due to the pandemic, and reduction or overall removal of access to other support resources. |
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Superior Mesenteric Artery Thrombosis in a Patient with COVID-19: A Unique Presentation |
Ucpinar, BA, Sahin, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Clinical data| Données cliniques |
In this case report,we present a case of superior mesenteric artery (SMA) thrombosis in a patient of COVID-19 pneumonia.
To our knowledge, this is the first case that demonstrates acute mesenteric ischemia in a patient with COVID-19 pneumonia. |
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Pharmacists’ response during a pandemic: A survey on readiness to test during COVID-19 |
Uebbing, E, Lacroix, et al |
Journal of the American Pharmacists Association |
Healthcare Response | Réponse des soins de santé |
The primary objective of this study was to investigate the views of pharmacists about pharmacist-ordered and -administered
COVID-19 testing. Expanding the pool of health care providers who can perform testing is critical to achieving and sustaining proposed testing thresholds. Rhode Island pharmacists are willing to take part in performing COVID-19 testing provided appropriate
PPE is available and services are reimbursed. |
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Vagni, M, Giostra, et al |
Sustainability (Switzerland) |
Mental Health |
|
The main aim of this study was to analyze the relationship of emergency stress and hardiness with burnout among emergency
workers. The participants included 494 emergency volunteers from the Red Cross Committee in Veneto, Italy, engaged in various health, emergency, and social activities aimed at COVID-19 patients and people at risk of contracting the virus.We analyzed the influence
of age, sex, weekly hours of service, stress risk factors, and use of personal protective equipment. To verify the predictive effects of risk and protective factors on burnout, correlational and multivariate analyses, and regressions were conducted. Hardiness
showed an effect in reducing emergency stress levels, emotional exhaustion, and depersonalization and simultaneously increased personal accomplishment. |
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|
Vaid, A, Somani, et al |
J Med Internet Res |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Clinical
data| Données cliniques |
The aims of this study were to analyze the electronic health records (EHRs) of patients who tested positive for COVID-19
and were admitted to hospitals in the Mount Sinai Health System in New York City; to develop machine learning models for making predictions about the hospital course of the patients over clinically meaningful time horizons based on patient characteristics
at admission; and to assess the performance of these models at multiple hospitals and time points. We used Extreme Gradient Boosting (XGBoost) and baseline comparator models to predict in-hospital mortality and critical events. Trends in performance on prospective
validation sets were similar. At 7 days, acute kidney injury on admission, elevated LDH, tachypnea, and hyperglycemia were the strongest drivers of critical event prediction, while higher age, anion gap, and C-reactive protein were the strongest drivers of
mortality prediction. These models identified at-risk patients and uncovered underlying relationships that predicted outcomes. |
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Outcomes in Hispanics With COVID-19 Are Similar to Those of Caucasian Patients in Suburban
New York |
Valenzuela, RG, Michelen, et al |
Academic Emergency Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We explored the association between Hispanic ethnicity and outcomes in COVID-19 patients in Long Island, New York.
Of all patients, 1,079 (53%) were non-Hispanic Caucasians and 960 (47%) were Hispanic. Compared with Caucasians, Hispanics were younger (45 years vs. 59 years), had fewer comorbidities (66% with no comorbidities vs. 40%), were less likely to have commercial
insurance (35% vs. 59%), or were less likely to come from a nursing home (2% vs. 10%). In univariate comparisons, Hispanics were less likely to be admitted (37% vs. 59%) or to die (3% vs. 10%). Age, shortness of breath, congestive heart failure (CHF), coronary
artery disease (CAD), hypoxemia, and presentation from nursing homes were associated with admission. Male sex and hypoxemia were associated with ICU admission. Male sex, chronic obstructive pulmonary disease, and hypoxemia were associated with IMV. Male sex,
CHF, CAD, and hypoxemia were associated with mortality. After other factors were adjusted for, Hispanics were less likely to be admitted (OR = 0.62, 95% CI = 0.52 to 0.92) but Hispanic ethnicity was not associated with ICU admission, IMV, or mortality. |
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Predicting the number of total COVID-19 cases and deaths in
Brazil by the Gompertz model |
Valle, JAM |
Nonlinear Dynamics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The authors used the Gompertz model to estimate the total number of COVID-19 cases and deaths in Brazil and two Brazilian
states. Based on data collected from the Ministry of Health from February 26, 2020, to July 2, 2020, we predict, from July 3 to 9 and at the end of the epidemic, the number of infected and killed for the whole country and for the Brazilian states of Sao Paulo
and Rio de Janeiro. We estimate, until July 9, 2020, a total of 1,709,755 cases and 65,384 deaths in Brazil, 331,718 cases and 15,621 deaths in Sao Paulo, 134,454 cases and 11,574 deaths in Rio de Janeiro. We also estimate the basic reproduction number R for
Brazil and its two states. The estimated values (R) were 1.3, 1.3, and 1.4 for Brazil, Sao Paulo, and Rio de Janeiro, respectively. The results show a good fit between the observed data and those obtained by the Gompertz. |
|
Van Bockel, D, Munier, et al |
Viruses |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study evaluated the virucidal activity of commercially available Viral Transport Mediums (VTMs) to inactivate
SARS-CoV-2. VTM formulations, Primestore® Molecular Transport Medium (MTM) and COPAN eNAT™ completely inactivated high-titre SARS-CoV-2 virus in as little as 2 min of VTM exposure and were compatible with POC processing. Adding certain VTM formulations as
a first step post specimen collection will render SARS-CoV-2 non-infectious for transport, or for further in-field POC molecular testing using rapid turnaround GeneXpert platforms or equivalent. |
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Statistical method to determine the need for hospitalization of COVID-19 patients |
Vasconcelos, FF, de Moura, et al |
Revista de Administracao Publica |
Clinical data| Données cliniques |
The general objective of this article is to propose a statistical method, based on logistic regression, capable of
indicating whether a patient who tests positive for COVID-19 should be directed to home isolation or be admitted to a hospital, based on blood tests and age. it is possible to predict with a reasonable degree of accuracy whether, upon arriving at the hospital
and testing positive, the individual should be recommended to isolate at home or be admitted to a healthcare facility. |
|
Vashistha, P, Gupta, et al |
Clin Chim Acta |
Clinical data| Données cliniques |
A 60 year old male subject who was on regular treatment for Type2 Diabetes Mellitus (T2DM) and hypertension, presented
in the emergency department with cough and sore throat for 5 days and shortness of breath for 3 days. He was tested for COVID-19 by RT-PCR which was found to be positive. He developed SARI, cytokines storm and septicaemia, treated with antibiotics, enoxaparin,
hydroxychloroquine, insulin, anti-hypertensives, put on ventilator, subsequently developed septicaemia, multi-organ failure and died. |
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Superspreaders and lockdown timing explain the power-law
dynamics of COVID-19 |
Vazquez, A |
Physical Review E |
Modelling/ prediction| Modélisation/prédiction Transmission |
Infectious disease outbreaks are expected to grow exponentially in time when left unchecked. Containment measures such
as lockdown and social distancing can drastically alter the growth dynamics of the outbreak. This is the case for the 2019-2020 COVID-19 outbreak, which is characterized by a power-law growth. Strikingly however, the power-law exponent is different across
countries. Here I illustrate the relationship between these two extreme scenarios, exponential and power-law growth, based on the impact of superspreaders and lockdown strategies to contain the outbreak. The theory predicts a relationship between the power-
law exponent and the time interval between the first case and lockdown that is validated by the observed COVID-19 data across different countries. © 2020 American Physical Society. |
|
Verkhivker, G |
Int J Mol Sci |
Coronavirology| Coronavirologie |
In this work, we performed a comprehensive computational investigation in which sequence analysis and modeling of coevolutionary
networks are combined with atomistic molecular simulations and comparative binding free energy analysis of the SARS-CoV and SARS-CoV-2 spike protein receptor binding domains with the ACE2 host receptor. Through coevolutionary network analysis and dynamics-based
alanine scanning, we established linkages between the binding energy hotspots and potential regulators and carriers of signal communication in the virus–host receptor complexes. The results of this study detailed a binding mechanism in which the energetics
of the SARS-CoV-2 association with ACE2 may be determined by cumulative changes of a number of residues distributed across the entire binding interface. |
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|
Viguerie, A, Lorenzo, et al |
Appl Math Lett |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
We present an early version of a Susceptible-Exposed-Infected-Recovered-Deceased (SEIRD) mathematical model based on
partial differential equations coupled with a heterogeneous diffusion model. The model describes the spatio-temporal spread of the COVID-19 pandemic, and aims to capture dynamics also based on human habits and geographical features. To test the model, we compare
the outputs generated by a finite-element solver with measured data over the Italian region of Lombardy, which has been heavily impacted by this crisis between February and April 2020. Our results show a strong qualitative agreement between the simulated forecast
of the spatio-temporal COVID-19 spread in Lombardy and epidemiological data collected at the municipality level. Additional simulations exploring alternative scenarios for the relaxation of lockdown restrictions suggest that reopening strategies should account
for local population densities and the specific dynamics of the contagion. |
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Covid-19 intervention scenarios for a long-term disease management |
Wallentin, G, Kaziyeva, et al |
International Journal of Health Policy and Management |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
In this paper we present a new agent-based simulation model “COVID-19 ABM” with which we simulate 4 alternative scenarios
for the second “new normality” phase that can help decision-makers to take adequate control and intervention measures. The scenarios resulted in distinctly different outcomes. A continued lockdown could regionally eradicate the virus within a few months, whereas
a relaxation back to 80% of former activity-levels was followed by a second outbreak. Contact-tracing as well as adaptive response strategies could keep COVID-19 within limits. |
|
Wammes, JD, Kolk, et al |
Journal of the American Medical Directors Association |
Mental Health |
|
The aim of this study was to capture perspectives from the relatives of nursing home residents on nursing home visiting
restrictions. There was no consensus among respondents if adverse effects of the visiting restrictions outweighed the protective effect for nursing home residents. Respondents expressed the need for increased information, communication options, and better
safety protocols. |
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Wang, X, Huang, et al |
Virol Sin |
Long-Term Sequelae |
|
This study aimed to investigate the cause of viral clearance delay and viral infectivity in COVID-19 patients with
persistent SARS-CoV-2 for more than 50 days post initial symptoms. All patients were clinically cured after long-term SARS-CoV-2 infection ranging from 53 to 112 days PIS. Overall, decreased IFN-γ production by NK cells and low neutralizing antibodies were
associated with SARS-CoV-2 long-term existence. Further, low viral load and weak viral pathogenicity were observed in COVID-19 patients with long-term SARS-CoV-2 infection. |
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High incidence and mortality of pneumothorax in critically Ill patients with
COVID-19 |
Wang, XH, Duan, et al |
Heart and Lung |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this retrospective study was to determine the epidemiology and risks of pneumothorax in the critically ill
patients with COVID-19 in a Chinese hospital. The incidence of pneumothorax was 10% (5/49) in patients with ARDS, 24% (5/21) in patients receiving mechanical ventilation, and 56% (5/9) in patients requiring invasive mechanical ventilation, with 80% (4/5) patients
died. All the 5 patients were male and aged ranging from 54 to 79 years old. Pneumothorax was most likely to occur 2 weeks after the beginning of dyspnea and associated with reduction of neuromuscular blockers, recruitment maneuver, severe cough, changes of
lung structure and function. |
|
Wathelet, M, Duhem, et al |
JAMA network open |
Mental Health |
|
The objective of this study was to measure the prevalence of self-reported mental health symptoms, to identify associated
factors, and to assess care seeking among university students who experienced the COVID-19 quarantine in France. The results of this survey study suggest a high prevalence of mental health issues among students who experienced quarantine. |
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Wawrzyk, A, Rybitwa, et al |
Przeglad epidemiologiczny |
Public Health response| Interventions de santé publique |
The aim was to present the actions, instructions and procedures introduced at the Auschwitz-Birkenau State Museum (A-BSM)
to provide information how to deal with pandemic caused by the SARS-CoV-2 coronavirus in institutions taking care of cultural heritage before and after closure of the Museum for visitors and after reopening. he described activities were developed at the Museum
by a specially established Expert Team. Groups of employees and places in which they were most exposed to contact with visitors and, as a consequence, at the highest risk of getting infected, were characterised. The employees were provided with personal protective
equipment, and at the Museum site, devices essential for maintaining the microbiological cleanliness of the rooms, were placed. In the next stage, instructions and procedures for particular groups of employees were prepared. Visitors were educated about the
need of taking precautions and were allowed to disinfect in several places at the Memorial Site. Steps to reduce attendance at this time has also been taken. Procedures for employees of the A-BSM were developed in such way that they can also be used after
reopening of the Museum for visitors. |
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|
Wernhart, S, Förster, et al |
BMC Infect Dis |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
METHODS: We analysed patients with respiratory symptoms reporting to our three rural general practitioner (GP) offices
in North Rhine-Westphalia, Germany, from 27.01-20.04.2020. A history of symptoms was taken at the doorstep following a specific questionnaire. RESULTS: Eighty patients (16.36%, mean age: 47.03 years+ - 18.08) were sent to a nasopharyngeal smear. Five patients
(6.25%) proved to be positive, four of whom had established risk factors for COVID-19. Overall, the most common symptoms were cough (83.75%), sore throat (71.25%), as well as myalgia and fatigue (66.25%). The most common diagnoses were rhinopharyngitis (37.22%)
and acute bronchitis (30.27%). |
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Bronchoscopy Manifestation In Severe COVID-19 Patient: Case Series |
Widysanto, Allen, Subagio Sutanto, et al |
Research Square prepub |
Clinical data| Données cliniques Therapeutics| Thérapeutique Healthcare Response |
Réponse des soins de santé |
An emergency bronchoscopy was performed on three patients not responding to oxygen therapy. Bronchial washing and
suction can be a life-saving modality as therapeutic effort. |
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Decline in mobility: Public transport in Poland in the time of the COVID-19 pandemic |
Wielechowski, M, Czech, et al |
Economies |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
The aim of the paper is to assess changes in mobility in public transport in Poland, as a consequence of the development
of the COVID-19 pandemic. The obtained results show that there is negative but insignificant relationship between human mobility changes in public transport and the number of new confirmed COVID-19 cases in Poland. The results might indicate that the forced
lockdown to contain the development of the COVID-19 pandemic has effectively contributed to social distancing in public transport in Poland and that government restrictions, rather than a local epidemic status, induce a greater decrease in mobility. |
|
Wolf, J, Kaiser, et al |
Clin Chim Acta |
Epidemiology| Épidémiologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes Immunology | Immunologie |
The aim of the study was to evaluate the performance of two different routinely used immunoassays in hospitalized and
outpatient COVID-19 cases. METHODS: The test characteristics of commercially available spike1 protein-based serological assays, determining IgA or IgG and nucleocapsid-based assays determining IgA, IgM or IgG were compared in 139 controls and 116 hospitalized
and outpatient COVID-19 cases. RESULTS: Hospitalized COVID-19 patients (n=51; 115 samples) showed significantly higher concentrations of antibodies against SARS-CoV-2 and differed from outpatient cases (n=65) by higher age, higher disease severity scores and
earlier follow up blood sampling. Sensitivity of the two IgG assays was comparable in hospitalized patients tested ≥ 14 days. In outpatient COVID-19 cases sensitivity was significantly lower in the VT-assay compared with the EI-assay. Assays for IgA and IgM
demonstrated a lack of specificity or sensitivity. |
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Prone position in wards for spontaneous breathing Covid-19 patients: a
retrospective study |
Wormser, Johan, Romanet, et al |
Research Square prepub |
Clinical data| Données cliniques Therapeutics| Thérapeutique Healthcare Response |
Réponse des soins de santé |
Study found that prone position in wards improved alveolar exchange during posture and is well-tolerated. This technique
could be used in any medical ward. |
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COVID-19 Plateau: A Phenomenon of Epidemic Development under Adaptive Prevention Strategies |
Wu, Ziqiang, Liao, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper proposes two extensions to the standard infectious disease models: (a) consider the prevention measures
adopted based on the current severity of the infection, those measures are adaptive and change over time. (b) multiple cities and regions are considered, with population movements between those cities/regions, while taking into account that each region may
have different prevention measures. The model proposed gives rise to a plateau phenomenon: the number of people infected by the disease stay at the same level during an extended period of time. |
|
Xu, Y, Xu, et al |
Frontiers in Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this multicenter, retrospective, observational study, we enrolled consecutive patients with COVID-19 who were admitted
to seven ICUs in Guangdong Province the the aim to describe the clinical features, treatment, and outcomes of patients with COVID-19 admitted to the intensive care unit (ICU). The results indicate that COVID-19 patients admitted to ICU were characterized by
fever, lymphopenia, acute respiratory failure, and multiple organ dysfunction. The mortality of ICU patients in Guangdong Province was relatively low with a small sample size (60-day mortality was 4.4%). |
|
|
Xu, Yuehao, Zhang, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins
de santé |
During the coronavirus disease 2019 (COVID-19) outbreak, every public health system faced the potential challenge of
medical capacity shortages. Infections without timely diagnosis or treatment may facilitate the stealth transmission and spread of the virus. Using infection and medical capacity information reported in Wuhan in China, New York State in the United States,
and Italy, we developed a dynamic susceptible-exposed-infected-recovered (SEIR) model to estimate the impact of medical capacity shortages during the COVID-19 outbreak at the city, state, and country levels. After accounting for the effects of travel restrictions
and control measures, we find that the number of infections in Wuhan could have been 39% lower than the actual number if the medical capacity were doubled in this city. Similarly, we find the less shortages in medical capacity in both New York state and Italy,
the faster decline in the daily infection numbers and the fewer deaths. This study provides a method for estimating potential shortages and explains how they may dynamically facilitate disease spreading during future pandemics such as COVID-19. |
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The Hidden Pandemic of Family Violence During COVID-19: Unsupervised Learning of Tweets |
Xue, J, Chen, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
BACKGROUND: Family violence (including intimate partner violence/domestic violence, child abuse, and elder abuse) is
a hidden pandemic happening alongside COVID-19. The rates of family violence are rising fast, and women and children are disproportionately affected and vulnerable during this time. OBJECTIVE: This study aims to provide a large-scale analysis of public discourse
on family violence and the COVID-19 pandemic on Twitter. METHODS: We analyzed over 1 million tweets related to family violence and COVID-19 from April 12 to July 16, 2020. We used the machine learning approach Latent Dirichlet Allocation and identified salient
themes, topics, and representative tweets. RESULTS: We extracted 9 themes from 1,015,874 tweets on family violence and the COVID-19 pandemic: (1) increased vulnerability: COVID-19 and family violence (eg, rising rates, increases in hotline calls, homicide);
(2) types of family violence (eg, child abuse, domestic violence, sexual abuse); (3) forms of family violence (eg, physical aggression, coercive control); (4) risk factors linked to family violence (eg, alcohol abuse, financial constraints, guns, quarantine);
(5) victims of family violence (eg, the LGBTQ lesbian, gay, bisexual, transgender, and queer or questioning] community, women, women of color, children); (6) social services for family violence (eg, hotlines, social workers, confidential services, shelters,
funding); (7) law enforcement response (eg, 911 calls, police arrest, protective orders, abuse reports); (8) social movements and awareness (eg, support victims, raise awareness); and (9) domestic violence-related news (eg, Tara Reade, Melissa DeRosa). CONCLUSIONS:
This study overcomes limitations in the existing scholarship where data on the consequences of COVID-19 on family violence are lacking. We contribute to understanding family violence during the pandemic by providing surveillance via tweets. This is essential
for identifying potentially useful policy programs that can offer targeted support for victims and survivors as we prepare for future outbreaks. |
|
Yan, Y, Yang, et al |
Endokrynologia Polska |
Clinical data| Données cliniques |
The objective of this paper was to investigate the clinical features and pulmonary CT imaging features of COVID-19
patients with diabetes mellitus. COVID-19 patients with diabetes mellitus and chronic hypertension are associated with increased inflammatory markers and disorders of glucose and lipid metabolism. |
|
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Dysregulated primary hemostasis in critically ill COVID-19 patients |
Yatim, Nader, Boussier, et al |
Research Square prepub |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We provide evidence that platelets contribute to disease severity with the identification of sP-selectin as a biomarker
for poor outcome. |
|
Effects of Subjective Successful Aging on Emotional and Coping Responses
to the COVID-19 Pandemic |
Yeung, Dannii, Chung, et al |
Research Square prepub |
Mental Health |
|
Findings of this study unveil the beneficial effects of subjective views of successful aging on emotional and coping
responses to the pandemic through alleviating their perception of time limitation. |
|
Yokoo, P, Fonseca, et al |
Einstein (Sao Paulo, Brazil) |
Clinical data| Données cliniques |
A male patient with flu-like symptoms and tomography and laboratory diagnosis of severe acute respiratory syndrome.
He developed acute cardiac dysfunction during admission and was submitted to a cardiac magnetic resonance imaging examination, which confirmed acute myocarditis, indicating cardiac involvement by coronavirus disease 2019. A review and discussion about coronavirus
disease 2019-related cardiac manifestations are reported, focusing on the imaging findings to make diagnosis. |
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You, Chong, Gai, et al |
Research Square prepub |
Transmission Public health interventions*| Interventions de sant&eacute; publique |
The transmission dynamics of COVID-19 in Wuhan support perspective that universal PT-PCR screening is essential to
detect hidden cases before lifting control measures. |
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Identification of risk factors for mortality associated with COVID-19 |
Yu, Y, Zhu, et al |
PeerJ |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Clinical
data| Données cliniques |
This study aimed to develop neural network models with predictors selected by genetic algorithms (GA). This study was
conducted in Wuhan Third Hospital from January 2020 to March 2020. Predictors were collected on day 1 of hospital admission. The primary outcome was the vital status at hospital discharge. Predictors were selected by using GA, and neural network models were
built with the cross-validation method. The final neural network models were compared with conventional logistic regression models. A total of 246 patients with COVID-19 were included for analysis. The mortality rate was 17.1% (42/246). Non-survivors were
significantly older (median (IQR): 69 (57, 77) vs. 55 (41, 63) years; p < 0.001), had higher high-sensitive troponin I (0.03 (0, 0.06) vs. 0 (0, 0.01) ng/L; p < 0.001), C-reactive protein (85.75 (57.39, 164.65) vs. 23.49 (10.1, 53.59) mg/L; p < 0.001), D-dimer
(0.99 (0.44, 2.96) vs. 0.52 (0.26, 0.96) mg/L; p < 0.001), and a-hydroxybutyrate dehydrogenase (306.5 (268.75, 377.25) vs. 194.5 (160.75, 247.5); p < 0.001) and a lower level of lymphocyte count (0.74 (0.41, 0.96) vs. 0.98 (0.77, 1.26) × 109/L; p < 0.001)
than survivors. The GA identified a 9-variable (NNet1) and a 32-variable model (NNet2). The NNet1 model was parsimonious with a cost on accuracy; the NNet2 model had the maximum accuracy. NNet1 (AUC: 0.806; 95% CI 0.693–0.919]) and NNet2 (AUC: 0.922; 95% CI
0.859–0.985]) outperformed the linear regression models. |
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Alzheimer′s and Parkinson′s diseases predict different
COVID-19 outcomes, a UK Biobank study |
Yu, Yizhou, Travaglio, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The increased vulnerability of the elderly and those with comorbidities, together with the prevalence of neurodegenerative
diseases with advanced age, led us to investigate the links between neurodegeneration and COVID-19. We analysed the primary health records of 13,338 UK individuals tested for COVID-19 between March and July 2020. We show that a pre-existing diagnosis of Alzheimer′s
disease predicts the highest risk of COVID-19 infection and mortality among the elderly. In contrast, Parkinson′s disease patients were found to be at increased risk of infection but not mortality from COVID-19. We conclude that there are disease-specific
differences in COVID-19 susceptibility among patients affected by neurodegenerative disorders. |
|
Zakary, O, Bidah, et al |
Journal of Applied Mathematics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this paper, a mathematical model is utilized to estimate and predict the situation of the new coronavirus pandemic
(COVID-19) in countries under quarantine measures. We consider two new classes of people, those who respect the quarantine and stay at home, and those who do not respect the quarantine and leave their homes for one or another reason. We investigate the impact
of people who underestimate the quarantine by considering an optimal control strategy to reduce this category and then reducing the number of the population at risk in Morocco. We provide several simulations to support our findings. |
|
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Zayet, S, Klopfenstein, et al |
New Microbes and New Infections |
Clinical data| Données cliniques |
To our knowledge, Complications such as pneumomediastinum and/or pneumothorax during the course of COVID-19 remain
rare and their mechanism is poorly described. We present a case of COVID-19 pneumonia associated with spontaneous pneumothorax, pneumomediastinum and subcutaneous emphysema in an immunocompetent patient with no past history of smoking or chronic obstructive
pulmonary disease (COPD). The only risk factor of this patient was prolonged cough. We hypothesize the mechanism underlying the pneumomediastinum is the aggressive disease pathophysiology in COVID-19 with an incresead risk of alveolar damage. © 2020 The Author(s) |
|
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COVID-19 Reverse Prediction and Assessment on the Diamond Princess Cruise Ship |
Zhang, J, Sun, et al |
Frontiers in Physics |
Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions
de santé publique |
In this paper we develop a homogeneous mixed difference system to describe the mechanism of transmission of COVID-19
on the cruise ship, reverse-predict the epidemic transmission trend from January 20 to February 20, 2020, including the daily number of infected people and the peak time of infection, estimate the range of the basic reproduction number of virus transmission
on the cruise ship, and assess the effects of prevention and control measures. It is concluded that the isolation of people, along with rapid and comprehensive detection of infections, play an important role in controlling the epidemic. In fact, the Japanese
government's emergency measures did have a certain effect on limiting the spread of COVID-19, but the number of infected people could have been reduced by at least 60% if all personnel on the cruise ship had been tested and isolated promptly as early as February
5. |
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Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved
drugs in vitro |
Zhang, Q, Chen, et al |
Cell Discovery |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here we combine genetics and chemical perturbation to demonstrate that ACE2-mediated entry of SARS-Cov and CoV-2 requires
the cell surface heparan sulfate (HS) as an assisting cofactor: ablation of genes involved in HS biosynthesis or incubating cells with a HS mimetic both inhibit Spike-mediated viral entry. We show that heparin/HS binds to Spike directly, and facilitates the
attachment of Spike-bearing viral particles to the cell surface to promote viral entry. We screened approved drugs and identified two classes of inhibitors that act via distinct mechanisms to target this entry pathway. Among the drugs characterized, Mitoxantrone
is a potent HS inhibitor, while Sunitinib and BNTX disrupt the actin network to indirectly abrogate HS-assisted viral entry. We further show that drugs of the two classes can be combined to generate a synergized activity against SARS-CoV-2-induced cytopathic
effect. |
|
Zhang, Rui, Zhang, et al |
Research Square prepub |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
An analysis of the clinical characteristics, laboratory findings and therapy for a set of laboratory confirmed COVID-19
cases admitted to hospital between January 16 and April 24 and followed to May 1.Age above 60 years old, male sex and symptoms such as fever, cough, chest tightness, headaches and fatigue were also related to severe COVID-19 and an outcome of death. In addition,
high temperature, high blood leukocyte and neutrophil counts, C-reactive protein and D-dimer levels, and alanine aminotransferase, aspartate aminotransferase, α-hydroxybutyrate dehydrogenase, lactate dehydrogenase and creatine kinase activities were related
to severe COVID-19 and an outcome of death, |
|
|
Zhang, YD, Satapathy, et al |
Machine Vision and Applications |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study proposed a novel deep learning model that can diagnose COVID-19 on chest CT more accurately and swiftly.
Our algorithm achieved a sensitivity of 93.28% ± 1.50%, a specificity of 94.00% ± 1.56%, and an accuracy of 93.64% ± 1.42%, in identifying COVID-19 from normal subjects. We proved using stochastic pooling yields better performance than average pooling and
max pooling. |
|
|
Zhou, J, Liu, et al |
Brain, behavior, and immunity |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Methods: Our study included 389,620 participants of European descent from the UK Biobank, of whom 3,884 received the
COVID-19 test and 1,091 were tested positive for COVID-19. We examined the association of COVID-19 status with an extensive list of 974 medical conditions and 30 blood biomarkers. Results: The most significant risk factors for COVID-19 include Alzheimer's
disease, dementia, and the overall category of delirium, dementia, amnestic and other cognitive disorders. Evidence suggesting associations of genetic variants in SARS-CoV-2 infection-related genes with COVID-19 and other phenotypes, such as an immune deficiency
and prostate cancer, was obtained. |
|
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Zhou, S, Mi, et al |
Ear Nose Throat J |
Clinical data| Données cliniques |
Authors discuss the analysis of fatal cases and the risk factors for death in Wuhan, China. Clinical and laboratory
parameters predicting poor prognosis including older age, baseline SOFA score >2, and respiratory rate >24 per minute were identified. |
|
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Zhou, Y, Hou, et al |
PLoS Biol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study aims to identify SARS-CoV-2 pathogenesis, disease manifestations, and COVID-19 therapies using network medicine
methodologies along with clinical and multi-omics observations. We incorporate SARS-CoV-2 virus-host protein-protein interactions, transcriptomics, and proteomics into the human interactome. Network proximity measurement revealed underlying pathogenesis for
broad COVID-19-associated disease manifestations. Analyses of single-cell RNA sequencing data show that co-expression of ACE2 and TMPRSS2 is elevated in absorptive enterocytes from the inflamed ileal tissues of Crohn disease patients compared to uninflamed
tissues, revealing shared pathobiology between COVID-19 and inflammatory bowel disease. Integrative analyses of metabolomics and transcriptomics (bulk and single-cell) data from asthma patients indicate that COVID-19 shares an intermediate inflammatory molecular
profile with asthma (including IRAK3 and ADRB2). To prioritize potential treatments, we combined network-based prediction and a propensity score (PS) matching observational study of 26,779 individuals from a COVID-19 registry. We identified that melatonin
usage (odds ratio OR] = 0.72, 95% CI 0.56-0.91) is significantly associated with a 28% reduced likelihood of a positive laboratory test result for SARS-CoV-2 confirmed by reverse transcription-polymerase chain reaction assay. Using a PS matching user active
comparator design, we determined that melatonin usage was associated with a reduced likelihood of SARS-CoV-2 positive test result compared to use of angiotensin II receptor blockers (OR = 0.70, 95% CI 0.54-0.92) or angiotensin-converting enzyme inhibitors
(OR = 0.69, 95% CI 0.52-0.90). Importantly, melatonin usage (OR = 0.48, 95% CI 0.31-0.75) is associated with a 52% reduced likelihood of a positive laboratory test result for SARS-CoV-2 in African Americans after adjusting for age, sex, race, smoking history,
and various disease comorbidities using PS matching. |
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Emerging Infectious Diseases |
Immunology | Immunologie Animal model | Modèle animal |
Authors inoculated 6 cattle with severe acute respiratory syndrome coronavirus 2 and kept them together with 3 uninoculated
cattle. They observed viral replication and specific seroreactivity in 2 inoculated animals, despite high levels of preexisting antibody titers against a bovine betacoronavirus. |
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Achar, A, Ghosh, et al |
Cells |
Review Literature| Revue de littérature |
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Possible role of Unani Pharmacology in COVID-19 - a narrative review |
Alam, MA, Gani, et al |
Rev Environ Health |
Review Literature| Revue de littérature |
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Alamoodi, AH, Zaidan, et al |
Expert Systems with Applications |
Review Literature| Revue de littérature |
SR: ScienceDirect, PubMed, Web of Science, IEEE Xplore and Scopus were searched from 1 January 2010 to 30 June 2020.
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Intravenous Immune Globulin Uses in the Fetus and Neonate: A Review |
Alsaleem, M |
Antibodies (Basel) |
Review Literature| Revue de littérature |
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Coronavirus and COVID-19 disease
in aquatic animals’ aspects |
Al-Taee, S, Al-Jumaa, et al |
Veterinary Practitioner |
Review Literature| Revue de littérature |
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Amimo, Floriano, Lambert, et al |
Research Square prepub |
Review Literature| Revue de littérature |
SR: searched medical databases up to 15 September 2020. Current evidence is largely speculative. Innovative COVID-19
resilient solutions calibrated to local vulnerabilities are vital to ensure continuity of care and prevent the emergence of further potentially larger crises. |
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Antwi, SH, Getty, et al |
Science of the Total Environment |
Review Literature| Revue de littérature |
ScR |
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Phytogenic Products and Phytochemicals as a Candidate Strategy to Improve Tolerance to Coronavirus |
Attia, YA, Alagawany, et al |
Frontiers in Veterinary Science |
Review Literature| Revue de littérature |
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Milk lactoferrin: A probable immunological agent against sars-cov-2: A review |
Azhar, J, Mohammadabadi, et al |
Basrah Journal of Agricultural Sciences |
Review Literature| Revue de littérature |
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Baird, BJ, Sung, et al |
Otolaryngol Clin North Am |
Review Literature| Revue de littérature |
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Experimental studies on COVID-19: Overview of the world scientific production |
Barros, LM, Galindo Neto, et al |
ACTA Paulista de Enfermagem |
Review Literature| Revue de littérature |
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Benoit-Dubé, L, Jean, et al |
Disabil Rehabil Assist Technol |
Review Literature| Revue de littérature |
SR: Four databases were included: MEDLINE, CINAHL, PsychINFO and, ERIC. These findings can help health care professionals
to make better decisions when deciding to recommend technology for their older clients.
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Persistence of sars-cov-2 in body fluids: A bystander or whistle blower |
Bora, I, Gogoi, et al |
Iranian Journal of Microbiology |
Review Literature| Revue de littérature |
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Social assistive robots in elderly care: Exploring the role of empathy |
Buono, P, Castellano, et al |
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Review Literature| Revue de littérature |
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The SARS-CoV-2 Pandemic in Latin America: the Need for Multidisciplinary Approaches |
Callejas, D, Echevarría, et al |
Current Tropical Medicine Reports |
Review Literature| Revue de littérature |
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The emerging role of vitamin c in the prevention and treatment of covid-19 |
Carr, AC, Rowe, et al |
Nutrients |
Review Literature| Revue de littérature |
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SARS-CoV-2 and HIV: Epidemiology, Treatment, and Lessons Learned from HIV |
Castel, AD, Wilbourn, et al |
AIDS reviews |
Review Literature| Revue de littérature |
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Managing COVID-19 Global Pandemic with High-Tech Consumer Wearables: A Comprehensive Review |
Channa, A, Popescu, et al |
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Review Literature| Revue de littérature |
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Chen, H, Huang, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Review Literature| Revue de littérature |
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Perspectives on Glucocorticoid treatment of COVID-19: a systematic review |
Cordeiro, LeonardoP, Linhares, et al |
Research Square prepub |
Review Literature| Revue de littérature |
SR: Studies in English, Portuguese and Spanish published since 2019 were included. The results showed great heterogeneity
in their designs and results, which precludes a reliable conclusion on the use of GCs in the treatment of COVID-19. |
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Dash, SP |
Journal of the Indian Institute of Science |
Review Literature| Revue de littérature |
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De Moraes, EM, De Almeida, et al |
Scientia Medica |
Review Literature| Revue de littérature |
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Divo, MJ, Oberg, et al |
Respiratory care |
Review Literature| Revue de littérature |
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Dragojevic Simic, V, Miljkovic, et al |
Int J Clin Pract |
Review Literature| Revue de littérature |
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Elisabeth, M, Maneesh, et al |
Frontiers in Public Health |
Review Literature| Revue de littérature |
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Viewpoint – could the belt and road initiative be derailed? An analysis of impediments to completion |
Enderwick, P |
Critical Perspectives on International Business |
Review Literature| Revue de littérature |
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Fang, X, Henao-Mejia, et al |
Curr Opin Pediatr |
Review Literature| Revue de littérature |
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Fontana, IC, Bongarzone, et al |
Trends in neurosciences |
Review Literature| Revue de littérature |
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De-escalation of medical therapy in inflammatory bowel disease |
Frias Gomes, C, Chapman, et al |
Curr Opin Pharmacol |
Review Literature| Revue de littérature |
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Galli, F, Pozzi, et al |
Frontiers in Psychiatry |
Review Literature| Revue de littérature |
SR-MA: Pubmed, Scopus, Embase, Medline, and Web of Science were searched. Health care professionals in general and
most of all frontline workers showed an association with a likely risk of developing psychiatric disorders following outbreaks and for at least three years later. Mental health interventions for professionals exposed to COVID-19 need to be immediately implemented. |
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Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations |
Garduño-Soto, M, Choreño-Parra, et al |
Arch Dermatol Res |
Review Literature| Revue de littérature |
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Golinelli, D, Boetto, et al |
J Med Internet Res |
Review Literature| Revue de littérature |
SR: conducted a systematic review of early COVID-19-related literature (from January 1 to April 30, 2020) by searching
MEDLINE and medRxiv. In the field of diagnosis, digital solutions that integrate with traditional methods, such as AI-based diagnostic algorithms based both on imaging and clinical data, appear to be promising. For surveillance, digital apps have already proven
their effectiveness; however, problems related to privacy and usability remain.
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Harnett, J, Oakes, et al |
Adv Integr Med |
Review Literature| Revue de littérature |
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Haroon, Z, Azad, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Review Literature| Revue de littérature |
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Harrison, AG, Lin, et al |
Trends in immunology |
Review Literature| Revue de littérature |
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Hasan, I, Rashid, et al |
Rom J Intern Med |
Review Literature| Revue de littérature |
SR: COVID-19 in kidney transplant patients is associated with high rate of disease severity and fatality. Higher LDH
and longer time since transplantation predicted both disease severity and mortality. None of the COVID-19 specific treatment correlated with, or improved disease outcome in kidney transplant recipients. |
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Animal Welfare and Livestock Supply Chain Sustainability Under the COVID-19 Outbreak: An Overview |
Hashem, NM, González-Bulnes, et al |
Frontiers in Veterinary Science |
Review Literature| Revue de littérature |
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Using Social Media to Communicate Sustainable Preventive Measures and Curtail Misinformation |
Hauer, MK, Sood, et al |
Frontiers in Psychology |
Review Literature| Revue de littérature |
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Hoang, VT, Gautret, et al |
Current Tropical Medicine Reports |
Review Literature| Revue de littérature |
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COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management |
Hossain, MF, Hasana, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
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Cardiovascular considerations in coronavirus disease 2019 with a special focus on arrhythmia |
Hu, TY, Lee, et al |
Journal of Innovations in Cardiac Rhythm Management |
Review Literature| Revue de littérature |
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Psychological effect of the COVID 19 pandemic on hospital health personnel based on impact scales |
Huamán, L, Ramon, et al |
|
Review Literature| Revue de littérature |
SR: five search platforms such as PubMed, Elsevier, The Lancet, Google academic and Scielo. The pandemic caused by
COVID-19 is having a negative impact on the mental health of health personnel and there are a variety of validated scales to measure the psychological effect. |
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Current Prevention of COVID-19: Natural Products and Herbal Medicine |
Huang, J, Tao, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
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Covid-19 and surgery: Challenging issues in the face of new normal – A narrative review |
Huda, F, Kumar, et al |
Annals of Medicine and Surgery |
Review Literature| Revue de littérature |
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Hurwitz, B, Issa, et al |
Current Treatment Options in Cardiovascular Medicine |
Review Literature| Revue de littérature |
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Hussain, K, Ambreen, et al |
Journal of Pharmaceutical Policy and Practice |
Review Literature| Revue de littérature |
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Iivari, N |
International Journal of Information and Learning Technology |
Review Literature| Revue de littérature |
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Ikeagwulonu, RC, Obeta, et al |
New Zealand Journal of Medical Laboratory Science |
Review Literature| Revue de littérature |
SR: PubMed/Medline, Google Scholar, AJOL and JSTOR was searched. The observations in this study provide evidence of
multiple organ involvement in COVID-19 disease. D-dimer, lactate dehydrogenase, lymphocytes, neutrophils, platelets, fibrinogen, NLR, oxygen index, and blood gases should be considered important in risk stratification to predict severe and fatal COVID-19 outcome
in hospitalised patients. |
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Jalali, A, Dabaghian, et al |
Phytother Res |
Review Literature| Revue de littérature |
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The COVID-19 pandemic: a challenge for US nonprofits' financial stability |
Johnson, AF, Rauhaus, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Review Literature| Revue de littérature |
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Threading the Pieces Together: Integrative Perspective on SARS-CoV-2 |
Kanakan, A, Mishra, et al |
Pathogens |
Review Literature| Revue de littérature |
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Kaplan, B |
International journal of medical informatics |
Review Literature| Revue de littérature |
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Khan, Fasihul, Stewart, et al |
medRxiv |
Review Literature| Revue de littérature |
SR-MA: Electronic databases, preprint servers and clinical trial registries were searched on 23rd October 2020. Meta-analysis
revealed substantial heterogeneity in reported findings of tocilizumab and an inconclusive effect from prospective studies. Currently available evidence for the efficacy of anakinra, siltuximab or sarilumab in Covid-19 is insufficient.
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Review on counter measures to coronavirus disease 2019 (COVID-19) pandemic, May 2020 |
Kidaka, T, Lokupathirage, et al |
Japanese Journal of Veterinary Research |
Review Literature| Revue de littérature |
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Covid-19 and the role of the security council as global health peacekeeper |
Kondoch, B |
Journal of International Peacekeeping |
Review Literature| Revue de littérature |
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Labrague, LeodoroJ |
medRxiv |
Review Literature| Revue de littérature |
SR: articles from PubMed, CINAHL, SCOPUS, MEDLINE and PsychINFO. Substantial evidence supports the effectiveness of
coping behaviours, psychological resilience, and social support to preserve psychological and mental health among HCWs during the COVID-19 pandemic. |
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Lai, CKC, Lam, et al |
Biochemical and biophysical research communications |
Review Literature| Revue de littérature |
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Laurell, AC |
Trimestre Economico |
Review Literature| Revue de littérature |
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Li, Xiaoming, Liu, et al |
Research Square prepub |
Review Literature| Revue de littérature |
SR-MA: We searched PubMed, EMBASE, China National Knowledge Infrastructure (CNKI) and Wanfang databases to identify
eligible studies (up to August 11, 2020). NLR has good predictive values on disease severity and mortality in patients with COVID-19 infection. Evaluating NLR can help clinicians identify potentially severe cases early, conduct early triage and initiate effective
management in time, which may reduce the overall mortality of COVID-19. |
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Li, Y, Ji, et al |
Journal of medical virology |
Review Literature| Revue de littérature |
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Liu, Y, Tu, et al |
Materials Today Advances |
Review Literature| Revue de littérature |
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Lu, D, Huang, et al |
Sci Total Environ |
Review Literature| Revue de littérature |
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Luis Pendola, G, Elizalde, et al |
ecancermedicalscience |
Review Literature| Revue de littérature |
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Luquain-Costaz, C, Rabia, et al |
Biochimie |
Review Literature| Revue de littérature |
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A clinic blueprint for post-COVID-19 RECOVERY: Learning from the past, looking to the future |
Lutchmansingh, DD, Knauert, et al |
Chest |
Review Literature| Revue de littérature |
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Brainstem Dysfunction in SARS-COV-2 Infection can be a Potential Cause of Respiratory Distress |
Machado, C, DeFina, et al |
Neurology India |
Review Literature| Revue de littérature |
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Majeed, MM, Durrani, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Review Literature| Revue de littérature |
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Chloroquine and Hydroxychloroquine in COVID-19: Practice Implications for Healthcare Professionals |
Mallhi, TH, Ahmad, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Review Literature| Revue de littérature |
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Review of the current discussion on Covid-19 in the field of social thought |
Maya-Ambía, CJ |
Trimestre Economico |
Review Literature| Revue de littérature |
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McDonnell, S, McNamee, et al |
European Journal of Obstetrics and Gynecology and Reproductive Biology |
Review Literature| Revue de littérature |
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Medhi, R, Srinoi, et al |
ACS Applied Nano Materials |
Review Literature| Revue de littérature |
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Predictors of mortality in patients with COVID-19–a systematic review |
Mehraeen, E, Karimi, et al |
European Journal of Integrative Medicine |
Review Literature| Revue de littérature |
SR: ystematic search was conducted of PubMed, Scopus, Embase, Google Scholar, and Web of Science databases. Findings
suggest that older age, hypertension, and diabetes mellitus conferred a significant increased risk of mortality among patients with COVID-19. In the multivariate analysis, only diabetes mellitus demonstrated an independent relationship with increased mortality. |
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The Asian region and COVID-19: approaches and gaps in controlling the virus |
Mehta, P |
Asian Education and Development Studies |
Review Literature| Revue de littérature |
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Lysosomotropic properties of sodium bicarbonate and covid-19 |
Mir, MA, Mansoor, et al |
Farmacia |
Review Literature| Revue de littérature |
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Miskowiak, KW |
Ugeskrift for laeger |
Review Literature| Revue de littérature |
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Bioactive Natural Antivirals: An Updated Review of the Available Plants and Isolated Molecules |
Mohan, S, Elhassan Taha, et al |
Molecules (Basel, Switzerland) |
Review Literature| Revue de littérature |
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Mui, LW, Lau, et al |
Emerg Radiol |
Review Literature| Revue de littérature |
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Müller-Wieland, D, Marx, et al |
Exp Clin Endocrinol Diabetes |
Review Literature| Revue de littérature |
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The rise of 3D Printing entangled with smart computer aided design during COVID-19 era |
Nazir, A, Azhar, et al |
Journal of Manufacturing Systems |
Review Literature| Revue de littérature |
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Nazmul Hoque, M, Chaudhury, et al |
PeerJ |
Review Literature| Revue de littérature |
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Neiva, MB, Carvalho, et al |
Revista da Sociedade Brasileira de Medicina Tropical |
Review Literature| Revue de littérature |
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Noce, E, Zorzanello, et al |
Nephrology nursing journal : journal of the American Nephrology Nurses' Association |
Review Literature| Revue de littérature |
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Orooji, Y, Sohrabi, et al |
Nano-Micro Letters |
Review Literature| Revue de littérature |
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Ortiz de Landazuri, I, Egri, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Managing cancer patients care during the COVID-19 outbreak: a literature investigate |
Özyer, Y, Yanmış, et al |
International Journal of Emergency Services |
Review Literature| Revue de littérature |
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Pangarsa, EA, Setiawan, et al |
Bali Medical Journal |
Review Literature| Revue de littérature |
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COVID-19 disease, obesity and micronutrients: An updated narrative review of the literature |
Papadopoulou, SK, Mantzorou, et al |
Nutrition and Food Science |
Review Literature| Revue de littérature |
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Papageorgiou, AC, Mohsin, et al |
Cells |
Review Literature| Revue de littérature |
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Emerging Molecular Prospective of SARS-CoV-2: Feasible Nanotechnology Based Detection and Inhibition |
Patra, S, Kerry, et al |
Frontiers in Microbiology |
Review Literature| Revue de littérature |
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Perry, T, Berglund, et al |
Housing Policy Debate |
Review Literature| Revue de littérature |
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Pinto, S, Quintarelli, et al |
J Neurol Sci |
Review Literature| Revue de littérature |
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Being an entrepreneur post-COVID-19 – resilience in times of crisis: a systematic literature review |
Portuguez Castro, M, Gómez Zermeño, et al |
Journal of Entrepreneurship in Emerging Economies |
Review Literature| Revue de littérature |
SR:
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Nucleic acid and immunological diagnostics for SARS-CoV-2: Processes, platforms and pitfalls |
Premraj, A, Aleyas, et al |
Diagnostics |
Review Literature| Revue de littérature |
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Protti, M, Mandrioli, et al |
J Pharm Biomed Anal |
Review Literature| Revue de littérature |
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Conduct of Clinical Trials in the Era of COVID-19: JACC Scientific Expert Panel |
Psotka, MA, Abraham, et al |
Journal of the American College of Cardiology |
Review Literature| Revue de littérature |
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Drinking water pollutants may affect the immune system: concerns regarding COVID-19 health effects |
Quinete, N, Hauser-Davis, et al |
Environ Sci Pollut Res Int |
Review Literature| Revue de littérature |
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Rabaan, AA, Al-Ahmed, et al |
Hum Vaccin Immunother |
Review Literature| Revue de littérature |
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Undergraduate neuroscience education: Meeting the challenges of the 21st century |
Ramirez, JJ |
Neuroscience letters |
Review Literature| Revue de littérature |
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COVID-19 Pandemic: Epidemiology, Etiology, Conventional and Non-Conventional Therapies |
Rauf, A, Abu-Izneid, et al |
Int J Environ Res Public Health |
Review Literature| Revue de littérature |
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Ręka, G, Korzeniowska, et al |
Przeglad epidemiologiczny |
Review Literature| Revue de littérature |
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Alteration, reduction and taste loss: Main causes and potential implications on dietary habits |
Risso, D, Drayna, et al |
Nutrients |
Review Literature| Revue de littérature |
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Viscoelastic Tests in the Evaluation of Haemostasis Disturbances in SARS-CoV2 Infection |
Rodrigues, A, Seara Sevivas, et al |
Acta Med Port |
Review Literature| Revue de littérature |
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The efficacy of remdesivir in coronavirus disease 2019 (COVID-19): A systematic review |
Roshanshad, A, Kamalipour, et al |
Iranian Journal of Microbiology |
Review Literature| Revue de littérature |
SR: performed a systematic search in Pubmed, Embase, Web of Science, Google scholar and MedRxiv for relevant observational
and interventional studies. 5-day course of Remdesivir therapy in COVID-19 patients is probably efficacious and safe, and patients with-out invasive mechanical ventilation benefit the most. Treatment can be extended to 10 days if satisfactory improvement is
not seen by day 5. Most benefits from Remdesivir therapy take place in the first 14 days of the start of the treatment. |
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Sadjadian, P, Wille, et al |
Cancers |
Review Literature| Revue de littérature |
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Defining IL-6 Levels in Healthy Individuals: A Meta-Analysis |
Said, EA, Al-Reesi, et al |
J Med Virol |
Review Literature| Revue de littérature |
MA: This is the first meta-analysis reporting the levels of IL-6 in the blood of healthy donors based on a large number
of studies and donors. Therefore the 95% CI values determined in our study could well serve as a reference range for quick decision making in clinical interventions particularly those aiming to inhibit IL-6 especially urgent interventions e.g. COVID-19.
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Sharma, A, Jaiswal, et al |
Annals of Hepatology |
Review Literature| Revue de littérature |
SR-MA: data from observational studies December 1, 2019, to June 30, 2020 was extracted. Our meta-analysis suggests
that acute liver injury and elevated liver enzymes were significantly associated with COVID-19 severity |
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Shawon, J, Akter, et al |
Curr Pharm Des |
Review Literature| Revue de littérature |
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Shoaib, A, Azmi, et al |
Curr Pharm Des |
Review Literature| Revue de littérature |
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Remdesivir: A potential game-changer or just a myth? A systematic review and meta-analysis |
Shrestha, DB, Budhathoki, et al |
Life Sciences |
Review Literature| Revue de littérature |
SR-MA: searched Pubmed, Scopus, Embase, and preprint sites. Remdesivir showed a better 14 days mortality profile, clinical
recovery, and discharge rate. Overall clinical improvement and clinical recovery were earlier among the remdesivir group. 10-day remdesivir showed more adverse outcome than 5-day course with no significant benefits. |
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Technical Perspectives of Contact-Tracing Applications on Wearables for COVID-19 Control |
Shubina, V, Ometov, et al |
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Review Literature| Revue de littérature |
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Simadibrata, DM, Pandhita, et al |
Journal of the Intensive Care Society |
Review Literature| Revue de littérature |
SR-MA: systematic literature search was done on 23 July 2020 to identify peer-reviewed studies, preprints, and grey
literatures. High PLR levels on admission were associated with severe COVID-19 cases. Therefore, the on-admission PLR level is a novel, cost-effective, and readily available biomarker with a promising prognostic role for determining the severity of COVID-19
patients. |
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Singh, A, Roy, et al |
Journal of Cellular and Molecular Anesthesia |
Review Literature| Revue de littérature |
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Steel, A, Wardle, et al |
Advances in Integrative Medicine |
Review Literature| Revue de littérature |
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Taher, M, Miroliaee, et al |
Archives of Iranian Medicine |
Review Literature| Revue de littérature |
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Tripathi, S, Tripathi, et al |
Veterinary World |
Review Literature| Revue de littérature |
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Tusé, D, Nandi, et al |
Frontiers in Plant Science |
Review Literature| Revue de littérature |
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Use of antiseptics in respiratory infections during the covid-19 pandemic |
Vikulov, GK |
Infektsionnye Bolezni |
Review Literature| Revue de littérature |
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Widyadharma, IPE, Dewi, et al |
Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
Review Literature| Revue de littérature |
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Wu, J, Tang, et al |
Frontiers in Neurology |
Review Literature| Revue de littérature |
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Hydrogen: A Potential New Adjuvant Therapy for COVID-19 Patients |
Yang, F, Yue, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
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Interdisciplinary bridging response teams for field hospitals in Wuhan during the COVID-19 pandemic |
Yu, Z, Hong, et al |
International Social Work |
Review Literature| Revue de littérature |
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Membrane heist: Coronavirus host membrane remodeling during replication |
Zhang, J, Lan, et al |
Biochimie |
Review Literature| Revue de littérature |
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Abbasinazari, M, Azizian, et al |
Journal of Cellular and Molecular Anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Abdelnabi, M, Leewlaviwat, et al |
Baylor University Medical Center Proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Humanizing practices in online learning communities during pandemics in the USA |
Abdi, NM, Gil, et al |
Journal of Professional Capital and Community |
Commentary/Editorial| Commentaire/Éditorial |
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Abuhammad, S |
Int J Clin Pract |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19’s challenges to urbanism: social distancing and the phenomenon of boredom in urban spaces |
Abusaada, H, Elshater, et al |
Journal of Urbanism |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7334958; Critically ill patients with COVID-19 and candidaemia: We must keep this in mind |
Agrifoglio, A, Cachafeiro, et al |
J Mycol Med |
Commentary/Editorial| Commentaire/Éditorial |
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Poised to Transform: Lessons Learned from COVID-19 in a School Library |
Ahlfeld, K |
Journal of Library Administration |
Commentary/Editorial| Commentaire/Éditorial |
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Akram-Lodhi, A |
Canadian Journal of Development Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Al Awaidy, ST, Khamis, et al |
Oman Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Alamé, K, Baicry, et al |
Medecine Therapeutique |
Commentary/Editorial| Commentaire/Éditorial |
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Infectious endocarditis of the prosthetic mitral valve after COVID-19 infection |
Alizadehasl, A, Salehi, et al |
Eur Heart J |
Commentary/Editorial| Commentaire/Éditorial |
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Potential use of RNA-dependent RNA polymerase (RdRp) inhibitors against SARS-CoV2 infection |
Allen, CNS, Arjona, et al |
All Life |
Commentary/Editorial| Commentaire/Éditorial |
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Amini, A, Chen, et al |
IEEE Journal of Biomedical and Health Informatics |
Commentary/Editorial| Commentaire/Éditorial |
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In case of COVID-19 pandemic, treat every patient referred to operating room as a COVID-19 one |
Aminnejad, R, Shafiee, et al |
Journal of Cellular and Molecular Anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Recruitment Strategy for Potential COVID-19 Convalescent Plasma Donors |
Andersen, KJ, Klassen, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Andrews, CD, Huang, et al |
Emerg Microbes Infect |
Commentary/Editorial| Commentaire/Éditorial |
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Locked in: What the COVID-19 pandemic spells for victims of
domestic violence |
Anjali, KK, Ranganathan, et al |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Aranguiz, A |
European Journal of Social Security |
Commentary/Editorial| Commentaire/Éditorial |
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How to restructure Euro area sovereign debt in the era of Covid-19 |
Arnold, T, Gulati, et al |
Capital Markets Law Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Arrigo, S, Alvisi, et al |
Digestive and Liver Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Athar, MH, Zubair, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Pandemic: Socio-Economic Consequences of Social Distancing Measures in Italy |
Auriemma, V, Iannaccone, et al |
Frontiers in Sociology |
Commentary/Editorial| Commentaire/Éditorial |
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New coronavirus: what does nursing have to learn and teach in times of a pandemic? |
Backes, MTS, Carvalho, et al |
Revista brasileira de enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
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Bai, H, Ji, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Lessons Learned from Teaching Cybersecurity Courses during Covid-19 |
Bai, Y, Gao, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Baker, E, Bentley, et al |
AHURI Final Report |
Commentary/Editorial| Commentaire/Éditorial |
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Balaji, SM |
Indian journal of dental research : official publication of Indian Society for Dental Research |
Commentary/Editorial| Commentaire/Éditorial |
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“Virtual Interdisciplinary COVID-19 Team”: A Hospital Pandemic Preparedness Approach |
Balkhair, A, Al Jufaili, et al |
Oman Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Strategic use of telemedicine for restarting urological outpatient services during COVID-19 pandemic |
Bansal, D, Chaturvedi, et al |
African Journal of Urology |
Commentary/Editorial| Commentaire/Éditorial |
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Barclay, AR, McGuckin, et al |
Frontline Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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Brazilian Nursing Process Research Network contributions for assistance in the COVID-19 pandemic |
Barros, ALBL, Silva, et al |
Revista brasileira de enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
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Multimodal strategy for hand hygiene in field hospitals of COVID-19 |
Batista, J, Silva, et al |
Revista brasileira de enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
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Re-imagining curriculum in India: Charting a path beyond the pandemic |
Batra, P |
Prospects |
Commentary/Editorial| Commentaire/Éditorial |
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Baxter, C, Abdool Karim, et al |
Biochemical and biophysical research communications |
Commentary/Editorial| Commentaire/Éditorial |
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Principles of intraoperative prevention in the coronovirus pandemic |
Bayramov, NY, Salahova, et al |
Azerbaijan Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Beery, T |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Collaborative practices from health care teams to face the covid-19 pandemic |
Belarmino, ADC, Rodrigues, et al |
Revista brasileira de enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
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Les biologistes sont plus armés pour dépister la pandémie de Covid-19 |
Benaderette, S |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19, Trends in Global Mission, and Participation in Faithful Witness |
Bendor-Samuel, P |
Transformation |
Commentary/Editorial| Commentaire/Éditorial |
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Bennett, S, Søreide, et al |
Current Oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Benton, SC, Fraser, et al |
Annals of Clinical Biochemistry |
Commentary/Editorial| Commentaire/Éditorial |
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Bermejo, JC |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Sars-CoV-2: émergence, aspects virologiques et diagnostiques |
Bertholom, C |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
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Institutional versus home isolation to curb the COVID-19 outbreak |
Bhadoria, Ajeet Singh, Gawande, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Bhaskar, S, Bradley, et al |
Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Restructuring paradigm in the wake of COVID-19: A study of Kerala model |
Bhaskaran, J, George, et al |
Journal of Human Behavior in the Social Environment |
Commentary/Editorial| Commentaire/Éditorial |
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In-hospital Mortality after Liver Transplantation due to COVID-19 |
Bhatti, ABH, Riyaz, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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Bhullar, KS, Drews, et al |
European journal of pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Bittencourt, MS, Generoso, et al |
Arquivos Brasileiros de Cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
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Boily-Larouche, G, Carson, et al |
BMC Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Boulos, N, Newman, et al |
Current Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Brooks, V |
Current Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Brubaker, R |
Thesis Eleven |
Commentary/Editorial| Commentaire/Éditorial |
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Prognostics and health management to improve resilient manufacturing |
Brundage, MP, Weiss, et al |
Smart and Sustainable Manufacturing Systems |
Commentary/Editorial| Commentaire/Éditorial |
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Psychische Belastungen in
der COVID-19-Pandemie: Allgemeine Verunsicherung |
Bühring, P |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Is religious intolerance good for your health? Reflections on Korea and covid-19 |
Burke, C |
Journal of Law, Religion and State |
Commentary/Editorial| Commentaire/Éditorial |
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Main indicators of textile enterprises' financial security assessment |
Burkhanov, AU, Tursunov, et al |
Vlakna a Textil |
Commentary/Editorial| Commentaire/Éditorial |
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Instructor roles in higher education during the COVID-19 pandemic |
Burnham, K, Narine, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Busacca, A |
European Data Protection Law Review |
Commentary/Editorial| Commentaire/Éditorial |
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Is the European Union going to help us overcome the COVID-19 crisis? |
Busch, D |
Capital Markets Law Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Pandemic diseases preparedness and response in the age of COVID-19-a symposium report |
Cable, J, Heymann, et al |
Ann N Y Acad Sci |
Commentary/Editorial| Commentaire/Éditorial |
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Cabral, A, Heather, et al |
Technology Architecture and Design |
Commentary/Editorial| Commentaire/Éditorial |
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Cahya Laksana, MA, Habibie, et al |
Systematic Reviews in Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
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The UK government’s COVID-19 policy: assessing evidence-informed policy analysis in real time |
Cairney, P |
British Politics |
Commentary/Editorial| Commentaire/Éditorial |
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Calapod, OP, Marin, et al |
Farmacia |
Commentary/Editorial| Commentaire/Éditorial |
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Calvey, T, Scheibein, et al |
J Addict Med |
Commentary/Editorial| Commentaire/Éditorial |
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Letter to the Editor in response to the article 'Candidate drugs against SARS-CoV-2 and COVID-19' |
Campesi, I, Montella, et al |
Pharmacol Res |
Commentary/Editorial| Commentaire/Éditorial |
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Severe alcohol-related liver disease admissions post-COVID-19 lockdown: Canary in the coal mine? |
Cargill, Z, Kattiparambil, et al |
Frontline Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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Carson, CC |
Postgrad Med |
Commentary/Editorial| Commentaire/Éditorial |
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Large-scale use of hydroxychloroquine for COVID-19 confirms safety, if not effectiveness |
Cavalli, G, Dagna, et al |
European journal of internal medicine |
Commentary/Editorial| Commentaire/Éditorial |
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India's cost-effective COVID-19 vaccine development initiatives |
Chakraborty, C, Agoramoorthy, et al |
Vaccine |
Commentary/Editorial| Commentaire/Éditorial |
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Chakraborty, D, Chaisse, et al |
Law and Development Review |
Commentary/Editorial| Commentaire/Éditorial |
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Chan, KH, Yuen, et al |
Int J Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
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Chanda, A |
Epidemiology and infection |
Commentary/Editorial| Commentaire/Éditorial |
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Chang, M, Green, et al |
Urban Design International |
Commentary/Editorial| Commentaire/Éditorial |
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Chapman, C, Bell, et al |
Journal of Professional Capital and Community |
Commentary/Editorial| Commentaire/Éditorial |
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Chapman, W |
Gastrointestinal Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Charra, B, Ellouadghiri, et al |
The Pan African medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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Chatterjee, S, Chakraborty, et al |
International Journal of Information Management |
Commentary/Editorial| Commentaire/Éditorial |
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Chen, C, Bergholm, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Chen, D, Zhou, et al |
Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Chen, H, Selix, et al |
Journal for Nurse Practitioners |
Commentary/Editorial| Commentaire/Éditorial |
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Chen, YT, Yen, et al |
International Journal of Environmental Research and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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"I Lost Track of Things": Student Experiences of Remote Learning in the Covid-19 Pandemic |
Chhetri, C |
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Commentary/Editorial| Commentaire/Éditorial |
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The impact of COVID-19 and the restoration of tuberculosis services in the Western Pacific Region |
Chiang, CY, Islam, et al |
The European respiratory journal |
Commentary/Editorial| Commentaire/Éditorial |
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Chin, SM |
Matter |
Commentary/Editorial| Commentaire/Éditorial |
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“Whatever it takes”: first budgetary responses to the COVID-19 pandemic in France |
Cho, CH, Jérôme, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
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Choi, JY |
Infection and Chemotherapy |
Commentary/Editorial| Commentaire/Éditorial |
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Asymptomatic health-care worker screening during the COVID-19 pandemic |
Chow, A, Htun, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Ciabattini, A, Garagnani, et al |
Semin Immunopathol |
Commentary/Editorial| Commentaire/Éditorial |
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HAVEN: A Unity-based Virtual Robot Environment to Showcase HRI-based Augmented Reality |
Cleaver, Andre, Tang, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Digital Cognitive Aids to Support Adaptation of Surgical Processes to COVID-19 Protective
Policies |
Conboy, HM, Kennedy-Metz, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Everyday Indigenous resurgence during COVID-19: a social media situation report |
Corntassel, J, Edgar, et al |
AlterNative |
Commentary/Editorial| Commentaire/Éditorial |
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Coyle, AM |
Physical Therapy Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Cuéllar, GR |
Revista Mexicana de Investigacion Educativa |
Commentary/Editorial| Commentaire/Éditorial |
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The Gendered Poverty Effects of the COVID-19 Pandemic in Colombia |
Cuesta, J, Pico, et al |
European Journal of Development Research |
Commentary/Editorial| Commentaire/Éditorial |
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Editorial: Proposals on self-care for diabetic foot during the COVID-19 pandemic in Brazil |
da Fonseca Cerqueira, MMB, das Merces, et al |
ACTA Paulista de Enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
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da Silva, PG, Mesquita, et al |
Sci Total Environ |
Commentary/Editorial| Commentaire/Éditorial |
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Da Silva, SJR, Mendes, et al |
Journal of General Virology |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Diagnosis and Viral Load Reporting: A Theory of Overdiagnosis and Undertesting |
Dai, Tinglong, Singh, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Dalmat, YM |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
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Dalmat, YM |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
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Dalmat, YM |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
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Dalmat, YM |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
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Brève: Covid-19: les anticorps peuvent devenir indétectables |
Dalmat, YM |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
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Brève: Médicaments contre-indiqués aux patients avec Covid-19 |
Dalmat, YM |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
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Dalmat, YM |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
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Danilewitz, M, Bahji, et al |
Can J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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David, AC, Pienknagura, et al |
Applied Economics Letters |
Commentary/Editorial| Commentaire/Éditorial |
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Equality of restraint: Reframing road safety through the ethics of private motorised transport |
Davis, AL, Obree, et al |
Journal of Transport and Health |
Commentary/Editorial| Commentaire/Éditorial |
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From Shattered Goals to Meaning in Life: Life Crafting in Times of the COVID-19 Pandemic |
de Jong, EM, Ziegler, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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De Souza, A, Tavora, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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de Souza, FF, Dainez, et al |
Praxis Educativa |
Commentary/Editorial| Commentaire/Éditorial |
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Potential Role of Autonomic Dysfunction in Covid-19 Morbidity and Mortality |
Del Rio, R, Marcus, et al |
Frontiers in Physiology |
Commentary/Editorial| Commentaire/Éditorial |
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Delaney, E |
British journal of nursing (Mark Allen Publishing) |
Commentary/Editorial| Commentaire/Éditorial |
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Della Rocca, DG, Magnocavallo, et al |
J Thromb Thrombolysis |
Commentary/Editorial| Commentaire/Éditorial |
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Demirag, I, Fırtın, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
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Deng, JL, Jiang, et al |
Chin Med J (Engl) |
Commentary/Editorial| Commentaire/Éditorial |
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Spontaneous hemothorax in 4 COVID-19 ARDS patients on VV-ECMO revealing pulmonary artery aneurysms |
Desnos, C, Boussouar, et al |
Crit Care |
Commentary/Editorial| Commentaire/Éditorial |
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Implications for the Care of Patients with COVID-19 and Inflammatory Myocardial Disease |
Di Tano, G, Iacovoni, et al |
JAMA Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Diamond, R, Byrd, et al |
J Affect Disord |
Commentary/Editorial| Commentaire/Éditorial |
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Diener, HC, Berlit, et al |
Nervenheilkunde |
Commentary/Editorial| Commentaire/Éditorial |
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How are university hospitals coping with the COVID-19 pandemic in Brazil? |
Dos Santos, JL, De Melo Lanzoni, et al |
ACTA Paulista de Enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
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Douglas, B |
Journal of Anglican Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Dowlati, E, Zhou, et al |
World Neurosurgery |
Commentary/Editorial| Commentaire/Éditorial |
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Drake, H, Abbey, et al |
Simul Healthc |
Commentary/Editorial| Commentaire/Éditorial |
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Traditional Chinese exercise for COVID-19: A protocol for systematic review and meta-analysis |
Duan, Y, Xiong, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Dubois, Cecile, Ruetsch, et al |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
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Dupuis, MJ, Renaud, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Durante, M, Schulze, et al |
Frontiers in Physics |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7487077; Common value: transferring development rights to make room for water |
Dyca, B, Muldoon-Smith, et al |
Environ Sci Policy |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 economic shocks and fiscal policy options for Ghana |
Dzigbede, KD, Pathak, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
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Eapen, V, Hiscock, et al |
J Paediatr Child Health |
Commentary/Editorial| Commentaire/Éditorial |
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How TB and COVID-19 compare: An opportunity to integrate both control programmes |
Echeverría, G, Espinoza, et al |
International Journal of Tuberculosis and Lung Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Epstein, J, Martin Smid, et al |
npj Vaccines |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and TURKMI, miRNAs in CAD, effects of cannabis and tramadol use, and more |
Erol, Ç |
Anatolian journal of cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Esposito, S, Zona, et al |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and
Lung Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Ettman, CK, Gradus, et al |
American Journal of Epidemiology |
Commentary/Editorial| Commentaire/Éditorial |
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Fathi, M, Vakili, et al |
Przeglad epidemiologiczny |
Commentary/Editorial| Commentaire/Éditorial |
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Spain: COVID-19 prompts smoking regulation in streets and terraces |
Fernández, E, Martínez, et al |
Tobacco control |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mental Health and Cancer: Why It Is Time to Innovate and Integrate-A Call to Action |
Fernando, A |
Eur Urol Focus |
Commentary/Editorial| Commentaire/Éditorial |
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Fischer, JC, Zänker, et al |
European journal of medical research |
Commentary/Editorial| Commentaire/Éditorial |
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Fishman, JA |
American Journal of Transplantation |
Commentary/Editorial| Commentaire/Éditorial |
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Chronological quarantine and ageism: COVID-19 and gerontology's relationship with age categorisation |
Fletcher, JR |
Ageing and Society |
Commentary/Editorial| Commentaire/Éditorial |
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Fricain, M, Moreau, et al |
Journal of Oral Medicine and Oral Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Frowde, R, Dove, et al |
Asian Bioethics Review |
Commentary/Editorial| Commentaire/Éditorial |
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Fry, M, Harris, et al |
Emerg Med Australas |
Commentary/Editorial| Commentaire/Éditorial |
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Screening for COVID-19 in Symptomatic Cancer Patients in a Cancer Hospital |
Fujiwara, Y, Sato, et al |
Cancer Cell |
Commentary/Editorial| Commentaire/Éditorial |
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Can You Hear Me Now? Communicating Across the COVID-19 PPE Chasm |
Fuller, G, Howell, et al |
Texas medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Telemedicine in urology: A crash course during
the COVID-19 pandemic |
Gadzinski, AJ, Ellimoottil, et al |
Urology Times |
Commentary/Editorial| Commentaire/Éditorial |
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Gali, S |
J Dent Educ |
Commentary/Editorial| Commentaire/Éditorial |
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Safety First: Expanding the Global Financial Safety Net in Response to COVID-19 |
Gallagher, KP, Gao, et al |
Global Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Galli, PF, Merini, et al |
Psicoterapia e Scienze Umane |
Commentary/Editorial| Commentaire/Éditorial |
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Gao, Y, Ye, et al |
World Journal of Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2: Einfluss von Diabetes auf ACE2 als Schlüsselfaktor einer Infektion |
Gappa, B |
Diabetologie und Stoffwechsel |
Commentary/Editorial| Commentaire/Éditorial |
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Garcia, LP, Sanchez, et al |
Cadernos de Saude Publica |
Commentary/Editorial| Commentaire/Éditorial |
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Communication and education in a digital connected world. Presentation |
García-Ruiz, R, Pérez-Escoda, et al |
Icono14 |
Commentary/Editorial| Commentaire/Éditorial |
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Garg, RK, Uniyal, et al |
Neurology India |
Commentary/Editorial| Commentaire/Éditorial |
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Garzaro, G, Declementi, et al |
Giornale italiano di medicina del lavoro ed ergonomia |
Commentary/Editorial| Commentaire/Éditorial |
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Home care as a safe alternative in post-acute and long-term care during COVID-19 crisis |
Gaspar, HA, Oliveira, et al |
Einstein (Sao Paulo, Brazil) |
Commentary/Editorial| Commentaire/Éditorial |
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Ghani, F |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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One semester of occupational therapy passed virtually: What experiences did we learn from
COVID-19? |
Gharib, M, Hosseini, et al |
Journal of Mazandaran University of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Gilardino, RE |
International Journal of Health Policy and Management |
Commentary/Editorial| Commentaire/Éditorial |
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Detraining Effects Prevention: A New Rising Challenge for Athletes |
Girardi, M, Casolo, et al |
Frontiers in Physiology |
Commentary/Editorial| Commentaire/Éditorial |
|
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The Institute for Health Protection and its role in tackling COVID-19 |
Glasper, A |
British journal of nursing (Mark Allen Publishing) |
Commentary/Editorial| Commentaire/Éditorial |
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Glasstone, R |
Dancing Times |
Commentary/Editorial| Commentaire/Éditorial |
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Goldenberg, NA, Sochet, et al |
Journal of Thrombosis and Haemostasis |
Commentary/Editorial| Commentaire/Éditorial |
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Goldman, G, Berridge, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Goldman, JD |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Quarantine, distress and interpersonal relationships during COVID-19 |
Goodwin, R, Hou, et al |
General Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Govender, K, Cowden, et al |
Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Panel: What COVID-19 is Teaching Professors: Pandemic-Level Changes in our Classrooms |
Greenberg, H, Bogaard, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Griffin, G, Hewison, et al |
Clin Med (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
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Arginine Depletion as a Therapeutic Approach for Patients with COVID-19 |
Grimes, JM, Khan, et al |
Int J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Group, Acpgbi Legacy Working |
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland |
Commentary/Editorial| Commentaire/Éditorial |
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Guda, NM |
Gastrointestinal Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Preparing for outbreaks – Implications for resilient water utility operations and services |
Gude, VG, Muire, et al |
Sustainable Cities and Society |
Commentary/Editorial| Commentaire/Éditorial |
|
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Risk Factors and Mental Health Promotion Strategies in Children During COVID-19 |
Guido, CA, Amedeo, et al |
Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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The value of voluntary COVID-19 securities disclosure - zero? |
Gulati, M |
Capital Markets Law Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Guo, L, Lin, et al |
International Eye Science |
Commentary/Editorial| Commentaire/Éditorial |
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Gupta, M, Jaiswal, et al |
Int J Gynaecol Obstet |
Commentary/Editorial| Commentaire/Éditorial |
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Gupta, S, Raghuwanshi, et al |
Sci Total Environ |
Commentary/Editorial| Commentaire/Éditorial |
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Győry, C, Weinberg, et al |
Theory and Practice of Legislation |
Commentary/Editorial| Commentaire/Éditorial |
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Hamasaki, T, Bretz, et al |
Statistics in Biopharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Estimation of population prevalence of COVID-19 using imperfect tests |
Hanin, L |
Mathematics |
Commentary/Editorial| Commentaire/Éditorial |
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Hantrais, L, Allin, et al |
Contemporary Social Science |
Commentary/Editorial| Commentaire/Éditorial |
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The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe COVID-19 Patients |
Hariharan, A, Hakeem, et al |
Inflammopharmacology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Harrison, P |
Gastrointestinal Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Pregnancy in the Time of COVID-19: Maternal Self-Focus and Kristevan Herethics |
Haylett Bryan, A |
Studies in Gender and Sexuality |
Commentary/Editorial| Commentaire/Éditorial |
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Held, P, Klassen, et al |
Cognitive and Behavioral Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Hennessy, S, Cohen, et al |
Am J Hypertens |
Commentary/Editorial| Commentaire/Éditorial |
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Ethical Responses to the COVID-19 Pandemic—Lessons from Sri Lanka |
Hettiarachchi, D, Noordeen, et al |
Asian Bioethics Review |
Commentary/Editorial| Commentaire/Éditorial |
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Hjiej, G, Fourtassi, et al |
Med Educ Online |
Commentary/Editorial| Commentaire/Éditorial |
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Hofer, RP |
Trimestre Economico |
Commentary/Editorial| Commentaire/Éditorial |
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What Role Should Chemistry Education Play in Addressing Societal Trust of Applications of Chemistry? |
Holme, TA |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
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Homma, A, Freire, et al |
Cadernos de saude publica |
Commentary/Editorial| Commentaire/Éditorial |
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Hough, A, Dell, et al |
International journal of palliative nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Hrenak, J, Simko, et al |
International journal of molecular sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Hu, Y, Xu, et al |
Chinese Sociological Review |
Commentary/Editorial| Commentaire/Éditorial |
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Huang, H, Park, et al |
Matter |
Commentary/Editorial| Commentaire/Éditorial |
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Responding to COVID-19: Healthcare Surge Capacity Design for High-Consequence Infectious Disease |
Hui, C, Zilm, et al |
Technology Architecture and Design |
Commentary/Editorial| Commentaire/Éditorial |
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Hunt, J |
Religions |
Commentary/Editorial| Commentaire/Éditorial |
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Proposed design of walk-through gate (WTG): Mitigating the effect of COVID-19 |
Hussain, S, Cheema, et al |
Applied System Innovation |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Rapid test missed over 50% of positive cases in Manchester pilot |
Iacobucci, G |
BMJ |
Commentary/Editorial| Commentaire/Éditorial |
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Idris, M, Nathaniel, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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Iivari, N, Sharma, et al |
Int J Inf Manage |
Commentary/Editorial| Commentaire/Éditorial |
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Ika, LA, Söderlund, et al |
International Journal of Project Management |
Commentary/Editorial| Commentaire/Éditorial |
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ABC triage and Protect phase strategy in COVID-19 management: lessons from the past |
Ish, P, Sakthivel, et al |
Postgrad Med J |
Commentary/Editorial| Commentaire/Éditorial |
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Use of 3D technology to support dermatologists returning to practice amid COVID-19 |
Ishack, S, Lipner, et al |
Cutis |
Commentary/Editorial| Commentaire/Éditorial |
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The levels of evidence for a medical/dental lecture: A guide for lecture selection |
Iwanaga, J, Matsushita, et al |
J Dent Educ |
Commentary/Editorial| Commentaire/Éditorial |
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Clinical microbiology laboratories and COVID-19: the calm before the storm |
J, MB |
Future Microbiol |
Commentary/Editorial| Commentaire/Éditorial |
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Jagannath, S, Agarwal, et al |
Gut |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: a preliminary assessment on the social security framework for an aged Malaysia |
Jamaluddin, SZ, Yuen Wah, et al |
Commonwealth Law Bulletin |
Commentary/Editorial| Commentaire/Éditorial |
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Jansson, M, Rubio, et al |
Anaesthesia Critical Care and Pain Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Jiang, H, Wang, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Jnr, BA, Nweke, et al |
Health and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Optimizing Public Library Resources in a Post COVID-19 World |
Jones, S |
Journal of Library Administration |
Commentary/Editorial| Commentaire/Éditorial |
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Fiscal and monetary response to the COVID-19 pandemic in India |
Jose, J, Mishra, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
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Editorial: Social media use in children and adolescents – on the good or the bad side of the force? |
Kaess, M |
Child and Adolescent Mental Health |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7543578; Management of Graves Thyroidal and Extrathyroidal Disease: An Update |
Kahaly, GJ |
J Clin Endocrinol Metab |
Commentary/Editorial| Commentaire/Éditorial |
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NeoBox — A Multipurpose Aerosol Box for Neonatal Care During COVID-19 Pandemic |
Kalane, S, Khambete, et al |
Indian pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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Kalra, A, Hawkins, et al |
Circulation: Cardiovascular Quality and Outcomes |
Commentary/Editorial| Commentaire/Éditorial |
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Compassion in a Crisis: The Role of Palliative Care During the COVID-19 Pandemic |
Kamal, AH, Casarett, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Kamani, L, Pausawasdi, et al |
Clinical Endoscopy |
Commentary/Editorial| Commentaire/Éditorial |
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Screening for Anti-Influenza Actives of Prefractionated Traditional Chinese Medicines |
Kang, Q, Wang, et al |
Evidence-based Complementary and Alternative Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Kar, A, Bhaumik, et al |
Journal of Oral Medicine and Oral Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Testing and surveillance strategies in the context of COVID-19 in India |
Karak, S, Srivastava, et al |
Indian Chemical Engineer |
Commentary/Editorial| Commentaire/Éditorial |
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Kenwick, MR, Simmons, et al |
International Organization |
Commentary/Editorial| Commentaire/Éditorial |
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Pharmacotherapeutic Modifications in Cardiopulmonary Patients during COVID-19 Outbreak |
Khan, IA |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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Khan, MA, Kumar, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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Possible Potential Outcomes from COVID-19 Complications on Testes: Lesson from SARS Infection |
Khan, R, Naseem, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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Modifying Surgical Practice in the Times of Current COVID-19 Pandemic |
Khan, RN, Khan, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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Polycythemia in SARS-CoV-2
Positive Patients: An Early Screening Marker |
Khan, TA |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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Kim, JY, Han, et al |
Int J Equity Health |
Commentary/Editorial| Commentaire/Éditorial |
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King, KM, Hartson, et al |
ACSM's Health and Fitness Journal |
Commentary/Editorial| Commentaire/Éditorial |
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King, S |
Gastrointestinal Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Kirby, Tony |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Ko, JP, Liu, et al |
Radiographics |
Commentary/Editorial| Commentaire/Éditorial |
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Komrad, MS |
Current Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Vaccine- and natural infection-induced mechanisms that could modulate vaccine safety |
Kostoff, RN, Kanduc, et al |
Toxicology Reports |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: Fat, obesity, inflammation, ethnicity, and sex differences |
Krams, IA, Luoto, et al |
Pathogens |
Commentary/Editorial| Commentaire/Éditorial |
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Kshirsagar, AF |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Ku, SS, Choe, et al |
Osong Public Health and Research Perspectives |
Commentary/Editorial| Commentaire/Éditorial |
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Kumar, A, Prasoon, et al |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
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How could we forget immunometabolism in SARS-CoV2 infection or COVID-19? |
Kumar, V |
Int Rev Immunol |
Commentary/Editorial| Commentaire/Éditorial |
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Lamichhane, JR, Reay-Jones, et al |
Crop Prot |
Commentary/Editorial| Commentaire/Éditorial |
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Lancman, G, Marcellino, et al |
Ann Hematol |
Commentary/Editorial| Commentaire/Éditorial |
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Lane, M, Kraft, et al |
Am J Infect Control |
Commentary/Editorial| Commentaire/Éditorial |
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Myoclonus and COVID-19: A Challenge for the Present, a Lesson for the Future |
Latorre, A, Rothwell, et al |
Movement Disorders Clinical Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Lawrence, P |
Review of African Political Economy |
Commentary/Editorial| Commentaire/Éditorial |
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Lee Lim, J, Ong, et al |
Malaysian Journal of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Guidelines for surgery of confirmed or suspected COVID-19 patients |
Lee, JS, Yum, et al |
Infection and Chemotherapy |
Commentary/Editorial| Commentaire/Éditorial |
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Leppert, A |
Celebrity Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Current status and thinking of small-molecule drug discovery for the treatment of COVID-19 |
Li, ZF, Wu, et al |
Journal of International Pharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Taiwan's budgetary responses to COVID-19: the use of special budgets |
Liao, WJ, Kuo, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
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Lichert, F |
Diabetologie und Stoffwechsel |
Commentary/Editorial| Commentaire/Éditorial |
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Lillo, A |
Lebende Sprachen |
Commentary/Editorial| Commentaire/Éditorial |
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Lim, JHR, Lim, et al |
Asia Pacific Journal of Social Work and Development |
Commentary/Editorial| Commentaire/Éditorial |
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Lima-Silva, F, Sandim, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
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A perspective on cervical cancer prevention and screening in Africa |
Lindeque, G |
Int J Gynaecol Obstet |
Commentary/Editorial| Commentaire/Éditorial |
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Lindner, S, Kubitschke, et al |
International Journal of Integrated Care |
Commentary/Editorial| Commentaire/Éditorial |
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Nursing education: challenges and perspectives in times of the COVID-19 pandemic |
Lira, ALBC, Adamy, et al |
Revista brasileira de enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
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An open world: How America can win the contest for twenty-first-century order |
Lissner, R, Rapp-Hooper, et al |
An Open World: How America Can Win the Contest for Twenty-First-Century Order |
Commentary/Editorial| Commentaire/Éditorial |
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Loo, RL, Lodge, et al |
J Proteome Res |
Commentary/Editorial| Commentaire/Éditorial |
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Lopez Santi, R, Piskorz, et al |
CJC Open |
Commentary/Editorial| Commentaire/Éditorial |
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Lord, H, Loveday, et al |
Intensive and Critical Care Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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The right to education and ict during covid-19: An international perspective |
Lorente, LML, Arrabal, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Lu, Haijun, Zhou, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Lundstrom, K, Seyran, et al |
Viruses |
Commentary/Editorial| Commentaire/Éditorial |
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MacKenzie, CR |
HSS Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Mahase, E |
BMJ |
Commentary/Editorial| Commentaire/Éditorial |
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Malhotra, S, Stanier, et al |
Biotechnology Law Report |
Commentary/Editorial| Commentaire/Éditorial |
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Manych, M |
Pneumologie |
Commentary/Editorial| Commentaire/Éditorial |
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Marabotto, E, Ziola, et al |
Liver Int |
Commentary/Editorial| Commentaire/Éditorial |
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Marcinkiewicz, J, Mazurek, et al |
Polish archives of internal medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Una hoja de ruta para la Vacuna COVID 19 en Colombia, un reto posible |
Marín, JEG, Osorio, et al |
Infectio |
Commentary/Editorial| Commentaire/Éditorial |
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The Effects of the COVID-19 Pandemic on the Practice of Avian Veterinary Medicine |
Marino, A |
Journal of Avian Medicine and Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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How are refugees affected by brazilian responses to COVID-19? |
Martuscelli, PN |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
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Need for a strong and reliable statistical
system in India: Lessons from a pandemic |
Mazumdar, S |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Weathering Pandemic Turbulence: It's All about Relationships |
McAllister, M |
Nursing leadership (Toronto, Ont.) |
Commentary/Editorial| Commentaire/Éditorial |
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McGee, C, Mayer, et al |
Public Works Management and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Experience of a surgeon at the emergency department during COVID-19 pandemic |
Mehanathan, PB, Edwards, et al |
Annals of Medicine and Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Adapting TB services during the COVID-19 pandemic in Mumbai, India |
Meneguim, AC, Rebello, et al |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and
Lung Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Current and evolving standards of care for patients with ARDS |
Menk, M, Estenssoro, et al |
Intensive Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Meylan, P |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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Mian, BM, Siddiqui, et al |
Urologic Oncology: Seminars and Original Investigations |
Commentary/Editorial| Commentaire/Éditorial |
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A technological and innovative approach to COVID-19 in Uruguay |
Milano, G, Vallespir, et al |
Communications of the ACM |
Commentary/Editorial| Commentaire/Éditorial |
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Minko, P, Bücker, et al |
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin |
Commentary/Editorial| Commentaire/Éditorial |
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Mohkhedkar, M, Venigalla, et al |
J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Molteni, F, Ladini, et al |
European Societies |
Commentary/Editorial| Commentaire/Éditorial |
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Monaghan, LF |
Sociol Health Illn |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of late administration of corticosteroids in COVID-19 ARDS |
Mongardon, N, Piagnerelli, et al |
Intensive Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Mora, S, Duarte, et al |
HardwareX |
Commentary/Editorial| Commentaire/Éditorial |
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Interleukin-1 receptor antagonist in the treatment of COVID-19 induced cytokine storm |
Moradi, O, Shojaei, et al |
Journal of Cellular and Molecular Anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Morens, DM, Fauci, et al |
Cell |
Commentary/Editorial| Commentaire/Éditorial |
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Mou, R, Jin, et al |
Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Sras-CoV-2 (Covid-19): Les différentes approches thérapeutiques |
Moutaouakkil, Y, Akrim, et al |
Medecine Therapeutique |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and Biomedical Publishing: Challenges and Prospects |
Mubarak, M |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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Mykhalovskiy, E, French, et al |
Sociol Health Illn |
Commentary/Editorial| Commentaire/Éditorial |
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Mykytyn, PP |
Information Systems Management |
Commentary/Editorial| Commentaire/Éditorial |
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Nadim, MK, Forni, et al |
Nature Reviews Nephrology |
Commentary/Editorial| Commentaire/Éditorial |
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What has been the telemedicine experience in urology during
the COVID-19 pandemic? |
Nash, K, Smith, et al |
Urology Times |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and the
precipitous dismantlement of societal norms |
Nasrallah, HA |
Current Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19:
Premières leçons sur les différences nationales de mortalité |
Nau, JY |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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The possibility and importance of immersive technologies during COVID-19 for autistic people |
Newbutt, N, Schmidt, et al |
Journal of Enabling Technologies |
Commentary/Editorial| Commentaire/Éditorial |
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Ng, JeremyY |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
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COVID -19: Protection of Workers at the Workplace in Singapore |
Ng, WT |
Safety and Health at Work |
Commentary/Editorial| Commentaire/Éditorial |
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Nguyen, E, Owens, et al |
J Community Health |
Commentary/Editorial| Commentaire/Éditorial |
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Niebler, S |
Society |
Commentary/Editorial| Commentaire/Éditorial |
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Norsa, L, D'Antiga, et al |
Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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O’Rourke, C |
Feminist Legal Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Oerther, DB, Shattell, et al |
Journal of Environmental Engineering (United States) |
Commentary/Editorial| Commentaire/Éditorial |
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Oleg, C, Mariana, et al |
Systematic Reviews in Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
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Olsen, MB |
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke |
Commentary/Editorial| Commentaire/Éditorial |
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orsteinsdóttir, B |
Laeknabladid |
Commentary/Editorial| Commentaire/Éditorial |
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Gastroenterological considerations in the framework of the COVID-19
pandemic |
Ortiz, G, Zubiri, et al |
Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Othman, R |
Accounting Research Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Activating Community Resilience: The Emergence of COVID-19 Funds Across the United States |
Paarlberg, LE, LePere-Schloop, et al |
Nonprofit and Voluntary Sector Quarterly |
Commentary/Editorial| Commentaire/Éditorial |
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Mobile health intervention and COVID-19 pandemic outbreak: insights from Indian context |
Pai, RR, Alathur, et al |
International Journal of Health Governance |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Is a Catalyst for Future Changes in Stroke Nursing Care |
Paletz, L |
J Neurosci Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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Pan, J |
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Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and Heart Failure: Harsh Reality of Pre-Existing Conditions |
Panjrath, GS, Krepp, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Park, DW, Yang, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Panic publishing: An unwarranted consequence of the COVID-19 pandemic |
Parmar, A |
Psychiatry research |
Commentary/Editorial| Commentaire/Éditorial |
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Could COVID-19 become a policy tipping point? a Q&A with Kavita K. Patel, MD, MS |
Patel, KK, Inserro, et al |
The American Journal of Managed Care |
Commentary/Editorial| Commentaire/Éditorial |
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Patel, M |
Cleanroom Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Patel, RK, Shackelford, et al |
Journal of the Acoustical Society of America |
Commentary/Editorial| Commentaire/Éditorial |
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Restructuration d’un service des urgences en milieu rural en préparation à la pandémie
de COVID-19 |
Patey, C, Asghari, et al |
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne |
Commentary/Editorial| Commentaire/Éditorial |
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Patwa, Parth, Sharma, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Maternal and child healthcare in India during COVID-19 pandemic |
Paul, P, Mondal, et al |
Midwifery |
Commentary/Editorial| Commentaire/Éditorial |
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Pervichko, E, Koniukhovskaia, et al |
Psychiatry, Psychotherapy and Clinical Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Pitts, PJ, Houÿez, et al |
Ther Innov Regul Sci |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2 antibody-based SURVEILLANCE: New light in the SHADOW |
Plebani, M |
EBioMedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Ponnada, S |
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Commentary/Editorial| Commentaire/Éditorial |
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Prakash, H, Upadhyay, et al |
Prostaglandins and Other Lipid Mediators |
Commentary/Editorial| Commentaire/Éditorial |
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Pandemic Pressures:COVID-19 Poses Serious Behavioral Health Challenges |
Price, S |
Texas medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Price, S |
Texas medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Indian public health associations on COVID-19:
The politics of knowledge |
Priya, R, Acharya, et al |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Protko, N, Pateyuk, et al |
Psychiatry, Psychotherapy and Clinical Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Quaranta-Leoni, F, Paridaens, et al |
Orbit |
Commentary/Editorial| Commentaire/Éditorial |
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Raffiq, A, Seng, et al |
Malaysian Journal of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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A smart image processing system for hall management including social distancing - "soDisCop" |
Rajarajeshwari, S, Archana, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Children’s mental health in the time of COVID-19: How things stand and the aftermath |
Ramadhan, MHA, Putri, et al |
Malaysian Journal of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Elimination of hepatitis C, our progress, challenges and hopes |
Rao, HY, Li, et al |
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology |
Commentary/Editorial| Commentaire/Éditorial |
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An Examination of COVID-19 Outbreaks in Prisons and Jails Throughout Asia |
Rapisarda, SS, Byrne, et al |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
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Rasanathan, K, Evans, et al |
Bulletin of the World Health Organization |
Commentary/Editorial| Commentaire/Éditorial |
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Rastogi, A, Tewari, et al |
Annals of cardiac anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Ray, UK |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7380206; Skin manifestations associated with the new coronavirus SARS-CoV-2 disease |
Redondo-Sendino, Á, González Sánchez, et al |
Med Clin (Barc) |
Commentary/Editorial| Commentaire/Éditorial |
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Clinical Trials for Inflammatory Bowel Disease: Global Guidance During the COVID-19 Pandemic |
Reinisch, W, Danese, et al |
Journal of Crohn's & colitis |
Commentary/Editorial| Commentaire/Éditorial |
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4/6. Increase in anxiety disorders during confinement in nursing homes |
Retailleau, B |
Soins Aides - Soignantes |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 pandemic and the motivations for demanding health service in indigenous villages |
Ribeiro, AA, Rossi, et al |
Revista brasileira de enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
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Actions by the courts of accounts to minimize effects of coronavirus |
Ribeiro, FO, Sallaberry, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
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Riemann, JF |
Gastroenterologe |
Commentary/Editorial| Commentaire/Éditorial |
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Riemann, JF |
MMW-Fortschritte der Medizin |
Commentary/Editorial| Commentaire/Éditorial |
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Ritter, O, Kararigas, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Riva, L, Petrini, et al |
Clinical Ethics |
Commentary/Editorial| Commentaire/Éditorial |
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Robbins, KC |
Nephrology nursing journal : journal of the American Nephrology Nurses' Association |
Commentary/Editorial| Commentaire/Éditorial |
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Using pulse oximetry to monitor high-risk patients with COVID-19 at home |
Rodriguez, C |
Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Rodriguez-Villa, E, Naslund, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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How important is the assessment of soluble ACE-2 in COVID-19? |
Rojas, M, Acosta-Ampudia, et al |
Am J Hypertens |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 era: How therapists can diminish burnout symptoms through self-care |
Rokach, A, Boulazreg, et al |
Current Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Rosenstock, JL, Bijol, et al |
J Am Soc Nephrol |
Commentary/Editorial| Commentaire/Éditorial |
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Essentially invisible: risk and personal support workers in the time of COVID-19 |
Rossiter, K, Godderis, et al |
Sociol Health Illn |
Commentary/Editorial| Commentaire/Éditorial |
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Roten, L |
Praxis |
Commentary/Editorial| Commentaire/Éditorial |
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Rowland, TAJ, Whitaker, et al |
J Infect |
Commentary/Editorial| Commentaire/Éditorial |
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Immune pathogenesis of COVID-19–related multisystem inflammatory syndrome in children |
Rowley, AH, Shulman, et al |
Journal of Clinical Investigation |
Commentary/Editorial| Commentaire/Éditorial |
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Rubin, R |
JAMA |
Commentary/Editorial| Commentaire/Éditorial |
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The impact of the covid-19 pandemic on the position of labor migrants from central asia in russia |
Ryazantsev, S, Vazirov, et al |
Central Asia and the Caucasus |
Commentary/Editorial| Commentaire/Éditorial |
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Saad-Filho, A |
Trimestre Economico |
Commentary/Editorial| Commentaire/Éditorial |
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Key motivators for driving work performance amid COVID-19 in developing nations |
Sadhna, P, Gupta, et al |
International Journal of Work Organisation and Emotion |
Commentary/Editorial| Commentaire/Éditorial |
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Sahu, A, Kapoor, et al |
Annals of cardiac anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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A Diagnostic Challenge in COVID-19 Pandemic: PCP or COVID-19 |
Sajjad, MM, Yousaf, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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Sakamto, D, Yoshida, et al |
Computer Software |
Commentary/Editorial| Commentaire/Éditorial |
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Salas, C, Quintana, et al |
Trimestre Economico |
Commentary/Editorial| Commentaire/Éditorial |
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Salinas, M |
Revista medica de Chile |
Commentary/Editorial| Commentaire/Éditorial |
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Factors limiting the utility of bronchoalveolar lavage in the diagnosis of COVID-19 |
Salton, F, Geri, et al |
Eur Respir J |
Commentary/Editorial| Commentaire/Éditorial |
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Sandifer, P, Knapp, et al |
Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Investing in innovative and productive capabilities for resilient economies in a post-COVID-19 world |
Santiago, F, de Fuentes, et al |
International Journal of Technological Learning, Innovation and Development |
Commentary/Editorial| Commentaire/Éditorial |
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Satre, DD, Iturralde, et al |
J Addict Med |
Commentary/Editorial| Commentaire/Éditorial |
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Government actions against the new coronavirus: Evidence from the Brazilian states |
Schaefer, BM, Resende, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
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Schaltegger, S |
Sustainability Accounting, Management and Policy Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Schlenger, RL |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Sebastian, S, Gonzalez, et al |
J Crohns Colitis |
Commentary/Editorial| Commentaire/Éditorial |
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Shafi, AMA, Awad, et al |
Journal of cardiac surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders |
Shahbazi, R, Yasavoli-Sharahi, et al |
Molecules (Basel, Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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TB and the COVID-19 pandemic: brothers in arms against lung health |
Shahriarirad, R, Fallahi, et al |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and
Lung Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Summarize the etiology and epidemiology characteristics of the new coronavirus |
Shen, S |
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Commentary/Editorial| Commentaire/Éditorial |
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Pandemic Politics: Political Worldviews and COVID-19 Beliefs and Practices in an Unsettled Time |
Shepherd, H, MacKendrick, et al |
Socius |
Commentary/Editorial| Commentaire/Éditorial |
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Filling an Educational Void with Spatial Thinking in the Online Age of Pandemics |
Sherwin, K, Winter, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Shi, J, Gao, et al |
Syst Rev |
Commentary/Editorial| Commentaire/Éditorial |
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Type 2 diabetic Asian Indians and COVID-19: Lessons learnt so far from the ongoing pandemic |
Shivane, VK, Lila, et al |
Journal of postgraduate medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Projection de la demande de lits de soins intensifs durant l’épidémie de COVID-19
au Canada |
Shoukat, A, Wells, et al |
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne |
Commentary/Editorial| Commentaire/Éditorial |
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Shrivastava, A, Mishra, et al |
World Neurosurgery |
Commentary/Editorial| Commentaire/Éditorial |
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Experience with Hemodialysis Patients in the COVID-19 Pandemic in Sakarya, Turkey |
Sipahi, S, Dheir, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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CGRP Receptor Antagonism in COVID-19: Potential Cardiopulmonary Adverse Effects |
Skaria, T, Wälchli, et al |
Trends in molecular medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Škiljić, A |
European Data Protection Law Review |
Commentary/Editorial| Commentaire/Éditorial |
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Introductions to the Community: Early-Career Researchers in the Time of COVID-19 |
Smith, Q, McKinley, et al |
Cell Stem Cell |
Commentary/Editorial| Commentaire/Éditorial |
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Could Virtual Reality play a role in the rehabilitation after COVID-19 infection? |
Smits, M, Bart Staal, et al |
BMJ Open Sport and Exercise Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus disease 2019 (COVID-19) Infection: Returning to sports/physical activity |
Sorace, P, Churilla, et al |
ACSM's Health and Fitness Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Sozzi, M, Algeri, et al |
Frontiers in Neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Comparison of Indian and New Zealand Leadership during COVID-19 |
Srinivasan, Raghavan, Kumar, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Staff, Plos Medicine |
PLoS medicine |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and the 24/7 News Cycle: Does COVID-19 News Exposure Affect Mental Health? |
Stainback, K, Hearne, et al |
Socius |
Commentary/Editorial| Commentaire/Éditorial |
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Observation of Retropharyngeal Fluid Collection in 2 COVID-19 Positive Patients |
Steehler, AJ, Ballestas, et al |
Ear Nose Throat J |
Commentary/Editorial| Commentaire/Éditorial |
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Stefanacci, RG |
Popul Health Manag |
Commentary/Editorial| Commentaire/Éditorial |
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Stevano, S, Ali, et al |
Canadian Journal of Development Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Stowe, MJ, Calvey, et al |
J Addict Med |
Commentary/Editorial| Commentaire/Éditorial |
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Stroman, L, Cathcart, et al |
BJU international |
Commentary/Editorial| Commentaire/Éditorial |
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Exergaming: An Effective Way to Maintain Physical and Mental Health at Home during COVID-19 Pandemic |
Sultan, N, Khushnood, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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Sundaram, JK |
Trimestre Economico |
Commentary/Editorial| Commentaire/Éditorial |
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Modified Suction Apparatus to Reduce the Transmission Risk of COVID-19 among Healthcare Providers |
Tandon, V, Raheja, et al |
Neurology India |
Commentary/Editorial| Commentaire/Éditorial |
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Predicting outcomes in COVID-19: From internal validation to improving care |
Taseen, R, Cantin, et al |
EBioMedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Tatu, AL, Nadasdy, et al |
Dermatologic Therapy |
Commentary/Editorial| Commentaire/Éditorial |
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Tempering Macrophage Plasticity for Controlling SARS-CoV-2 Infection for Managing COVID-19 Disease |
Toor, D, Jain, et al |
Frontiers in Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Toraih, EA, Hussein, et al |
Ann Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Number of COVID-19 patients classified as cured: an imminent danger for the population |
Tovani-Palone, M, Lacagnina, et al |
Einstein (Sao Paulo, Brazil) |
Commentary/Editorial| Commentaire/Éditorial |
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Asymptomatic health-care worker screening during the COVID-19 pandemic – Authors' reply |
Treibel, TA, Manisty, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 innovations in medication for addiction treatment at a Skid Row syringe
exchange |
Tringale, R, Subica, et al |
Journal of substance abuse treatment |
Commentary/Editorial| Commentaire/Éditorial |
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Tripura, B |
Social Work with Groups |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Pandemic-driven Innovations in Optometric Education |
Twa, MD |
Optometry and vision science : official publication of the American Academy of Optometry |
Commentary/Editorial| Commentaire/Éditorial |
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Ullah, R, Ong, et al |
Archives of Iranian Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Pandemic: Nephrology Experiences - Voices from the
Frontlines: Part 2 |
Ulrich, B |
Nephrology nursing journal : journal of the American Nephrology Nurses' Association |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of the COVID-19 pandemic on rural tourism in Czechia Preliminary considerations |
Vaishar, A, Šťastná, et al |
Current Issues in Tourism |
Commentary/Editorial| Commentaire/Éditorial |
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Intranational differences in the case fatality rates for COVID-19 among Peruvian
physicians |
Valenzuela-Rodriguez, G, Zambrano, et al |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Occupational COVID-19: what can be learned from notifications of occupational diseases? |
van der Molen, HF, Kezic, et al |
Occup Environ Med |
Commentary/Editorial| Commentaire/Éditorial |
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Vaňková, E, Kašparová, et al |
PeerJ |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations on pediatric cardiopulmonary resuscitation (CPR)
during the COVID-19 pandemic |
Vassallo, JC, Curi, et al |
Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Management perspectives from the 2019 Wuhan international workshop on fulminant myocarditis |
Veronese, G, Ammirati, et al |
International journal of cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Vicente, CR, Sant'Ana, et al |
Revista da Sociedade Brasileira de Medicina Tropical |
Commentary/Editorial| Commentaire/Éditorial |
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Viscusi, WK |
Journal of Risk and Uncertainty |
Commentary/Editorial| Commentaire/Éditorial |
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Can dexamethasone prevent the seizures induced by SARS-CoV-2 infection? |
Vizuete, AFK, Gonçalves, et al |
Multiple Sclerosis and Related Disorders |
Commentary/Editorial| Commentaire/Éditorial |
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Walker, L |
Texas medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Opioid Use Disorder in the Emergency Department Amid COVID-19 |
Walter, LA, Li, et al |
J Addict Med |
Commentary/Editorial| Commentaire/Éditorial |
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Wang, G, Wang, et al |
Transl Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Fibrinolysis is a reasonable alternative for STEMI care during the COVID-19 pandemic |
Wang, N, Zhang, et al |
Journal of International Medical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Wang, S, Chen, et al |
European Societies |
Commentary/Editorial| Commentaire/Éditorial |
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Security control components for epidemic prevention donation management blockchain |
Wang, S, Li, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Weidemaier, WMC, Gulati, et al |
Capital Markets Law Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Whiteside, A, van Wyngaard, et al |
African Journal of AIDS Research |
Commentary/Editorial| Commentaire/Éditorial |
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Whitney, K, McCormick, et al |
Sociol Health Illn |
Commentary/Editorial| Commentaire/Éditorial |
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Institutional versus home isolation to curb the COVID-19 outbreak – Authors' reply |
Wilder-Smith, Annelies, Cook, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Witz, J |
Urology Times |
Commentary/Editorial| Commentaire/Éditorial |
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Que peuvent apprendre les pays de la réponse de Hong Kong à la pandémie de COVID-19? |
Wong, SYS, Kwok, et al |
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne |
Commentary/Editorial| Commentaire/Éditorial |
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Atténuer les effets psychologiques de la COVID-19 sur les travailleurs de la santé |
Wu, PE, Styra, et al |
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne |
Commentary/Editorial| Commentaire/Éditorial |
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Nosocomial infection prevention and control: Another main battlefield for new coronavirus pneumonia |
Wu, Q |
Chinese Journal of Evidence-Based Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19, the Anthropocene, and the Imperative of US–China Cooperation |
Wu, T |
EcoHealth |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of the COVID-19 pandemic on the detection of TB in Shanghai, China |
Wu, Z, Chen, et al |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and
Lung Disease |
Commentary/Editorial| Commentaire/Éditorial |
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If skin is a potential host of SARS-CoV-2, IL-17 antibody could reduce the risk of COVID-19 |
Xu, Q, Chen, et al |
J Am Acad Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Yakass, MB, Quaye, et al |
Future Microbiol |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19
and heart failure: sirtuin-1 activation-mediated alleviation |
Yamini, B, Dhandapani, et al |
Current science |
Commentary/Editorial| Commentaire/Éditorial |
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Yang, H, Chi, et al |
Frontiers in Neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2 |
Yang, HJ, Zhang, et al |
European Respiratory Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Yang, J, Yu, et al |
Zhonghua yu fang yi xue za zhi Chinese journal of preventive medicine] |
Commentary/Editorial| Commentaire/Éditorial |
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Yang, Y, Li, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus disease 2019 pandemic: what does wearing masks mean? |
Yang, Y, Song, et al |
Chin Med J (Engl) |
Commentary/Editorial| Commentaire/Éditorial |
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Yassine, S, Sanchez Moreno, et al |
Neuro-Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
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Ultrasound Imaging: A Silent Hero in COVID-19 and Lung Diagnostics |
Yu, ACH, Demi, et al |
IEEE transactions on ultrasonics, ferroelectrics, and frequency control |
Commentary/Editorial| Commentaire/Éditorial |
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Yu, H, Li, et al |
J Proteome Res |
Commentary/Editorial| Commentaire/Éditorial |
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Yu, Z, Wang, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Zamfiroiu, A, Constantinescu, et al |
Applied Sciences (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Should I be Concerned? Surgical Training in the Time of COVID19 |
Zuberi, MK, Nizam, et al |
Journal of Surgical Education |
Commentary/Editorial| Commentaire/Éditorial |
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Zuckier, LS |
Eur J Nucl Med Mol Imaging |
Commentary/Editorial| Commentaire/Éditorial |
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Zuniga, JM |
AIDS reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Science and Suspicion: Maxim Gorky’s Children of the Sun as a Critical Mirror in Times of COVID-19 |
Zwart, H |
Law, Culture and the Humanities |
Commentary/Editorial| Commentaire/Éditorial |
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Zweifel, P |
Economic Affairs |
Commentary/Editorial| Commentaire/Éditorial |
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Commentary/Editorial| Commentaire/Éditorial |
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ICEEG 2020 - 2020 4th International
Conference on E-commerce, E-Business and E-Government |
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Commentary/Editorial| Commentaire/Éditorial |
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Aktuelle Ernahrungsmedizin |
Commentary/Editorial| Commentaire/Éditorial |
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American Journal of Transplantation |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations for care
of pediatric patients with SARS-CoV-2 infection |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations on neonatal cardiopulmonary resuscitation (CPR)
during the SARS-CoV-2 pandemic |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations
for high risk infants follow-up programmes during the SARS-CoV-2 pandemic |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in Argentina, what is the current epidemiological situation? |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Epidemiological update of COVID-19 in Pediatrics. Epidemiological
week 32 |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Post-COVID-19 multisystem
inflammatory syndrome in Pediatrics. Update document |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Intubation in pediatric patients with suspected or confirmed COVID-19 |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations on the transport
of pediatric patients positive or suspected of COVID-19 |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations applied to functional respiratory tests at the
time of COVID-19. July 2020 |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Archivos Argentinos de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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BMJ (Clinical research ed.) |
Commentary/Editorial| Commentaire/Éditorial |
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BMJ Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Clinical cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Deutsche medizinische Wochenschrift |
Commentary/Editorial| Commentaire/Éditorial |
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ESMO open |
Commentary/Editorial| Commentaire/Éditorial |
|
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Infection Control and Hospital Epidemiology |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 cutaneous manifestations: simplifying the confusion |
|
Int J Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
|
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JAMA - Journal of the American Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
|
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Journal of Allergy and Clinical Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
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The Journal of bone and joint surgery.American volume |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Journal of Clinical Orthopaedics and Trauma |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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Therapy of Hodgkin lymphoma in Russia during the COVID-19 pandemic |
|
Journal of Modern Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
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Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID research updates: A vaccine that mimics the coronavirus prompts potent antibodies |
|
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
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Asteroid 'fist bump', pooling COVID tests and open-access deal |
|
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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The New England journal of medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.*
Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.
Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers.
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Séquelles à long terme:
Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.
Santé mentale:
Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées
à la pandémie.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives