Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-11-09
Good afternoon,
There are 386 citations in today’s scan. 212 were considered primary research or review literature.
Highlights today include:
CANADA
·
Furman et al.
(preprint) proposes an approach to predict demand for PPE. By estimating the total workload of each class, we derive closed-form estimates for the expected amount of PPE required over a specified time horizon using current PPE guidelines. We apply our
approach to a data set of 22,039 patients admitted to the general internal medicine department at St. Michael's hospital in Toronto, Canada from April 2010 to November 2019. We find that gloves and surgical masks represent approximately 90% of predicted PPE
usage. We also find that while demand for gloves is driven entirely by patient-practitioner interactions, 86% of the predicted demand for surgical masks can be attributed to the requirement that medical practitioners will need to wear them when not interacting
with patients.
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Mac et al
conducted a population-based cohort study using public health data to describe COVID-19 associated age- and sex-specific acute care use, length of stay (LOS), and mortality in Ontario. During the observation period, 56,476 COVID-19 cases were reported.
The proportion of cases shifted from older populations (> 60 years) to younger populations (10-39 years) over time. Overall, 10% of individuals were hospitalized, of those 22% were admitted to ICU, and 60% of those used IMV. All outcomes varied by age and
decreased over time, overall and within age groups.
PUBLIC HEALTH INTERVENTION
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Lelieveld et al
present an adjustable algorithm to estimate the infection risk for different indoor environments, constrained by published data of human aerosol emissions, SARS-CoV-2 viral loads, infective dose and other parameters. Results suggest that aerosols from
highly infective subjects can effectively transmit COVID-19 in indoor environments. This “highly infective” category represents approximately 20% of the patients who tested positive for SARS-CoV-2. A particularly effective mitigation measure is the use of
high-quality masks, which can drastically reduce the indoor infection risk through aerosols.
EPIDEMIOLOGY
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Zambrano et al.
provide an update from the CDC regarding women of reproductive age with symptomatic, laboratory-confirmed SARS-CoV-2 infection. Although the absolute risks for severe outcomes for women were low, pregnant women were at increased risk for severe COVID-19-associated
illness. Pregnant women were significantly more likely to be admitted to an intensive care unit, receive invasive ventilation, receive extracorporeal membrane oxygenation and die.
·
Sims et. al.
Presence of anti-SARS-CoV-2 IgG in blood and online assessment of demographic, and clinical was collected from 20,614 participants out of ~43,000 total employees at Beaumont Health, Michigan. A total of 1,818 (8.8%) participants
were seropositive, 44% reported that they were asymptomatic during collection. Healthcare roles such as phlebotomy, respiratory therapy, and nursing/nursing support exhibited significantly higher seropositivity. Among participants reporting direct exposure
to a COVID-19 positive individual, those wearing an N95/PAPR mask had a significantly lower seropositivity rate (10.2%) compared to surgical/other masks (13.1%) or no mask (17.5%).
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Kirbiyik et. al. Analysis of detained person and staff member movements during a COVID-19 outbreak at Cook County Jail
in Illinois found fewer connections among detained persons with COVID-19 than expected, suggesting that interventions and medical isolation practices were effective at reducing transmission. Higher than expected connections were identified in staff member
networks, suggesting occurrence of additional transmission and areas of focus for transmission interruption.
LONG TERM SEQUELAE
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Yang et al
characterize the viral RNA level and serum antibody responses in recurrent-positive patients and evaluate their viral transmission risk. Of 479 recovered COVID-19 patients, 93 recurrent-positive patients were identified, characterized by younger age,
with a median discharge-to-recurrent-positive length of 8 days. After readmission, recurrent-positive patients exhibited mild or absent symptoms, with no disease progression. Recurrent-positive patients pose a low transmission risk, a relatively relaxed management
of recovered COVID-19 patients is recommended.
CLINICAL DATA
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Achua et al
evaluated the presence of and analyzed the pathological changes within the testes of patients who died or recovered from COVID-19 complications. Histomorphology showed three of the six COVID-19 biopsies had normal spermatogenesis while the remaining
three had impaired spermatogenesis. TEM showed the COVID-19 virus in testis tissue of one COVID-19 positive autopsy case and the live biopsy, H&E stain on the same autopsy case demonstrated interstitial macrophage and leukocyte infiltration.
VACCINE RESEARCH
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Ward et al., assess the safety, tolerability, and immunogenicity of CoVLP at three dose levels (3.75 microgram, 7.5 microgram, and 15 microgram)
unadjuvanted or adjuvanted in 180 SARS-CoV-2 seronegative healthy adults 18 to 55 years of age. CoVLP administered with either CpG1018 or AS03 has a safety profile similar to other candidate vaccines for SARS-CoV-2. The antibody titers achieved were either
similar to or at least 10-times higher than those seen in convalescent plasma.
CORONAVIROLOGY
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Yao et al
report the mutation spectrum, replication dynamics, and infectivity of 11 patient-derived viral isolates in diverse cell lines. We observed 46 mutations, including 9 different mutations in the spike gene. Importantly, these viral isolates show significant
and consistent variations in replication dynamics and infectivity in tested cell lines. We show that the variations in viral titers among viral isolates are positively correlated with blood clotting function but inversely correlated with the amount of red
blood cell and hemoglobin in patients.
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Li et al
identified, by comparing the genomic sequences of SARS-CoV-2 and human, five fully conserved elements in SARS-CoV-2 genome, which were termed as “human identical sequences (HIS)”. Our results revealed that unprecedented HIS elements of SARS-CoV-2 contribute
to the cytokine storm and ARDS in COVID-19 patients. Thus, blocking HIS-involved activating processes or hyaluronan synthesis directly by 4-MU may be effective strategies to alleviate COVID-19 progression.
DIAGNOSTICS
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Soares et. al. report the development of an integrated modular centrifugal microfluidic platform to perform loop-mediated isothermal
amplification (LAMP) of viral RNA directly from heat-inactivated nasopharyngeal swab samples. The platform provided results within 1 hour from sample collection and a detection limit between 100 and 1000 RNA copies in 10 μL reaction volume with Ct values below
26, ∼94% sensitivity and 100% specificity.
PUBLIC HEALTH RESPONSE
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Prandi et al. studied the process of false information transmission by malicious agents, in the context
of a disease pandemic based on data for the COVID-19 emergency in Italy. They model communication of misinformation based on a negative trust relation and provide an agent-based simulation. They consider the effects of a misinfodemic on policies related to
lockdown strategies, isolation, protection and distancing measures, and overall negative impact on society during a pandemic. They conclude that there is a clear impact by misinfodemics in aggravating the results of a current pandemic.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley
Otten, Irene Yong, Drew Greydanus, Shalane Ha, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics /
Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance,
Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, Immunologie,
économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Association of COVID-19 pandemic with undergraduate medical students' perceived stress and coping |
Abdulghani, HM, Sattar, et al |
Psychology Research and Behavior Management |
Epidemiology| Épidémiologie Mental Health |
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This cross-sectional study determined the effect of the current pandemic on undergraduate medical students’ learning.
And also explored the association of their stress level with coping strategies, educational, and psychological variables. The prevalence of overall stress was significantly higher (χ2= 16.3; P=0.000) in female medical students, ie, (40%) as compared to the
male students (16.6%), and was highest (48.8%) during the 3rd medical year. It was also noted that the most effective strategy, embraced by students to cope with the severe stress, was “indulging in religious activities” (OR= 1.08; P=0.81). Furthermore, 22.3%
of students had perceived severe stress as they did not prefer online learning. Similarly, those students who have not believed or refused the online learning or disagree in “there is pleasure in the study due to COVID” they have significantly higher stress
(χ2=39.7; P=0.000) 21.5% mild, 17.8% of moderate, and 21.2% severe. |
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Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections on Testis |
Achua, JK, Chu, et al |
World J Mens Health |
Clinical data| Données cliniques |
This study evaluated the presence of and analyzed the pathological changes within the testes of patients who died or recovered from COVID-19 complications.
H&E histomorphology showed three of the six COVID-19 biopsies had normal spermatogenesis while the remaining three had impaired spermatogenesis. TEM showed the COVID-19 virus in testis tissue of one COVID-19 positive autopsy case and the live biopsy, H&E stain
on the same autopsy case demonstrated interstitial macrophage and leukocyte infiltration. Immunofluorescent stained slides from six COVID-19 positive men demonstrated a direct association between increased quantitative ACE-2 levels and impairment of spermatogenesis.
This study suggests the male reproductive tract, specifically the testes, may be targets of COVID-19 infection. |
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Ajaz, S, McPhail, et al |
Am J Physiol Cell Physiol |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
This study investigated functional mitochondrial changes in live peripheral blood mononuclear cells (PBMCs) from COVID-19 patients, decipher the pathways
of substrate utilization in these cells and corresponding changes in the inflammatory pathways. Demonstrated mitochondrial dysfunction, metabolic alterations with an increase in glycolysis and high levels of mitokine in PBMCs from COVID-19 patients. Interestingly
found that levels of FGF-21 mitokine correlate with COVID-19 disease severity and mortality. These data suggest that COVID-19 patients have compromised mitochondrial function and an energy deficit which is compensated by a metabolic switch to glycolysis. This
metabolic manipulation by SARS-CoV-2 triggers an enhanced inflammatory response which contributes to severity of symptoms in COVID-19. Targeting mitochondrial metabolic pathway(s) can help define novel strategies for COVID-19. |
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SARS-Cov-2 Viral Load as an Indicator for COVID-19
Patients Hospital Stay |
AlAli, Salman Yousif, Abdulrahman, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This cross sectional study used the qPCR cycle of threshold (Ct) as a tool in evaluating the severity of the infection and hence the length of hospital
stay to better utilize and manage the healthcare resources. Out of 306 patients, 2 deaths, 1 active stable case and 303 recovered cases were reported. Ct value was significantly and negatively associated (P value <0.001) with length of hospital stay. Ct
value was inversely associated with hospital stay duration (and time to viral clearance), higher the Ct value is indicative of faster time to viral clearance. This association could help to better manage the infection and resources allocation. |
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Caputo SIR Model for COVID-19 under Optimized Fractional Order |
Alshomrani, AliS, Ullah, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This research study examined the possibilities and extents to which the SIR model fits the real data for the cases chosen from 01 April to 15 March, 2020,
Pakistan. To further analyze qualitative behavior of the Caputo SIR model, uniqueness conditions under the Banach contraction principle are discussed and stability analysis with basic reproduction number is investigated using Ulam-Hyers and its generalized
version. Best parameters have been obtained via nonlinear least-squares curve fitting technique. The infectious compartment of the Caputo SIR model fits the real data better than classical version of the SIR model . Average absolute relative error under the
Caputo operator is about 48% smaller than the one obtained in the classical case (ν = 1). Time series and 3D contour plots offer social distancing to be the most effective measure to control the epidemic. |
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Psychological consequences of COVID-19 home confinement: The ECLB-COVID19 multicenter
study |
Ammar, A, Mueller, et al |
PLoS One |
Mental Health |
|
An international online survey (ECLB-COVID19) was launched on April 6, 2020 in seven languages to elucidate the impact
of COVID-19 restrictions on mental health and emotional wellbeing. Analysis was conducted on the first 1047 replies (54% women) from Asia (36%), Africa (40%), Europe (21%) and other (3%). The COVID-19 home confinement had a negative effect on both mental-wellbeing
and on mood and feelings. Specifically, a significant decrease (p < .001 and Δ% = 9.4%) in total score of the mental wellbeing (SWEMWS) questionnaire was noted. More individuals (+12.89%) reported a low mental wellbeing "during" compared to "before" home
confinement. Furthermore, results from the mood and feelings questionnaire showed a significant increase by 44.9% (p < .001) in depressive symptoms (SMFQ) total score with more people (+10%) showing depressive symptoms "during" compared to "before" home confinement. |
|
Amoo, M, Horan, et al |
Ir J Med Sci |
Healthcare Response | Réponse des soins de santé |
This study assessed the implications of the COVID-19 pandemic on the provision of neuro-oncology surgery and comparison
with a similar 3-month period in 2019. During the 3-month periods studied in 2020 and 2019, there were 127 and 139 admissions for neuro-oncological surgery, respectively. Sixty patients underwent surgery for gliomas during the 2020 period vs 56 in the 2019
period. Observed no increase in mean length of time from referral to inter-hospital transfer (mean of 76 h in 2020 vs 93 h in 2019 (p = 0.10)) or in mean length of time from admission to surgery in the acute admissions (2.39 days in 2020 vs 2.89 days in 2019).
The postoperative 30-day morbidity and mortality rates were lower in 2020; 8.7% (n = 11) compared with 10.1% (n = 14) in 2019. There was one COVID-19-related death which occurred in a patient with B cell lymphoma with negative preoperative COVID-19 test. |
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Arif, M, Sengupta, et al |
Environment, Development and Sustainability |
Epidemiology| Épidémiologie |
This research studied the district wise transmissions of the novel coronavirus in five south Indian states until 20th
July 2020 and its relationship with their respective population density. The analysis has found that COVID-19 transmission in four states (Kerala, Tamil Nadu, Karnataka and Telangana) strongly hinges upon the spatial distribution of population density. It
is found that Tamilnadu has the highest corona positive cases followed by Karnataka and Andhra Pradesh state. Among all five south Indian states, Kerala has the lowest positive cases and the highest recovery rate for corona virus infections. However, the mortality
rate is very low in south Indian states in comparison with the country. The findings of this study show that the number of confirmed cases typically increased in areas with high density and thereafter areas with medium to low density. The spatial study in
different districts of five south Indian states found that Tamilnadu, Telangana, Karnataka and Kerala have positive relation between population density and COVID-19 positive cases. |
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Arnetz, JE, Goetz, et al |
Int J Environ Res Public Health |
Mental Health |
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This study explored the perceptions of the most salient sources of stress in the early stages of the coronavirus pandemic
in U.S. nurses. A cross-sectional online survey was conducted among a sample of 695 U.S. nurses in May 2020. Content analysis was conducted on nurses' responses (n = 455) to an open-ended question on the most stressful situations they had experienced during
the pandemic. Six distinct themes emerged from the analysis: exposure/infection-self; illness/death-others; workplace; personal protective equipment/supplies; unknowns; opinions/politics. Two sub-themes concerned restrictions associated with the pandemic and
feelings of inadequacy/helplessness regarding patients and their treatment. More than half of all comments concerned stress related to problems in workplace response to the pandemic. |
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Attanayake, AMCH, Perera, et al |
Computational and mathematical methods in medicine |
Epidemiology| Épidémiologie |
The number of daily new infections and cumulative number of infections in COVID-19 over four selected countries, namely,
Sri Lanka, Italy, the United States, and Hebei province of China, from the first day of appearance of cases to 2nd July 2020 were used in the study. Results revealed that the most appropriate growth curves for Sri Lanka, Italy, the United States, and China
(Hebei) are the logistic, Gompertz, Weibull, and Gompertz curves, respectively. Country-wise, overall growth rate, final epidemic size, and short-term forecasts were evaluated using the selected model. Daily log incidences in each country were regressed before
and after the identified peak time of the respective outbreak of epidemic. Hence, doubling time/halving time together with daily growth rates and predictions was estimated. Findings and relevant interpretations demonstrate that the outbreak seems to be extinct
in Hebei, China, whereas further transmissions are possible in the United States. In Italy and Sri Lanka, current outbreaks transmit in a decreasing rate. |
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Avram, S, Bologa, et al |
Nucleic Acids Res |
Therapeutics| Thérapeutique |
DrugCentral is a public resource (http://drugcentral.org) that serves the scientific
community by providing up-to-date drug information, as described in previous papers. The current release includes 109 newly approved (October 2018 through March 2020) active pharmaceutical ingredients in the US, Europe, Japan and other countries; and two molecular
entities (e.g. mefuparib) of interest for COVID19. In the context of the COVID19 pandemic, we also incorporated REDIAL-2020, a machine learning platform that estimates anti-SARS-CoV-2 activities, as well as the 'drugs in news' feature offers a brief enumeration
of the most interesting drugs at the present moment. The full database dump and data files are available for download from the DrugCentral web portal. |
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Bagate, F, Tuffet, et al |
Ann Intensive Care |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study aimed to evaluate the capacity of inhaled nitric oxide (iNO)-almitrine combination to restore oxygenation
in severe COVID-19 ARDS (C-ARDS) patients. Ten severe C-ARDS patients were assessed (7 males and 3 females), with a median age of 60 52-72] years. Combination of iNO and almitrine outperformed iNO alone for oxygenation improvement. The median of PaO(2)/FiO(2)
ratio varied from 102 89-134] mmHg at baseline, to 124 108-146] mmHg after iNO (p = 0.13) and 180 132-206] mmHg after iNO and almitrine (p < 0.01). We found no correlation between the increase in oxygenation caused by iNO-almitrine combination and that caused
by proning. |
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Bal, Antonin, Brengel-Pesce, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
A comprehensive assessment of COVID-19 in healthcare workers (HCWs) including the investigation of viral shedding duration
is critical. Of the 319 HCWs included, 67 (21.0%) were tested positive for SARS-CoV-2; two of them developed severe COVID-19. The proportion of smell and taste dysfunction was significantly higher in SARS-CoV-2 positive HCWs than in negative ones (38.8% vs
9.5% and 37.3% vs 10.7%, respectively, p 5.0 log10 cp/ml (Ct value 37). More than 90% of culturable virus had a viral load > 4.5 log10 cp/ml (Ct < 26) and were collected within 10 days after symptom onset. From HCWs tested negative, 6/190 (3.2%) exhibited
seroconversion for IgG antibodies. |
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Italians on the Age of COVID-19: The Self-Reported Depressive Symptoms Through Web-Based
Survey |
Balsamo, M, Carlucci, et al |
Frontiers in Psychology |
Mental Health |
|
The purpose of this study was to assess the prevalence of depressive symptoms in specific sociodemographic categories
during the COVID-19 quarantine lockdown and the potential factors that contribute to, or mitigate, these effects. In the very early stage of the nationwide lockdown, 3,672 quarantined Italian adult residents (65% females, ranging from 18 to 85 years) participated
in a web-based cross-sectional survey. The overall prevalence was 27.8% for moderate and 9.3% for severe levels of depressive symptoms. Females, younger people, students, singles, residents in northern Italy, people who were reluctant to adhere to quarantine
guidelines, and people less worried about being infected with COVID-19 were at high risk of developing depressive symptoms during the COVID-19 epidemic, also after controlling for state anxiety. These findings showed that public levels of depressive symptoms
did not increase the greater likelihood of being infected. |
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Baruah, C, Devi, et al |
BioMed research international |
Coronavirology| Coronavirologie |
This paper has attempted the structure prediction and functional analysis of two such accessory proteins, 9b and ORF14,
in the absence of experimental structures. Sequence analysis, structure prediction, functional characterization, and evolutionary analysis based on the UniProtKB reviewed the amino acid sequences of SARS-CoV-2 9b (P0DTD2) and ORF14 (P0DTD3) proteins. Tunnel
analysis revealed the presence of 1-2 highly active tunneling sites, perhaps which will able to provide certain inputs for advanced structure-based drug design or to formulate potential vaccines in the absence of a complete experimental structure. The evolutionary
analysis of both proteins of human SARS-CoV-2 indicates close relatedness to the bat coronavirus. The whole-genome phylogeny indicates that only the new bat coronavirus followed by pangolin coronaviruses has a close evolutionary relationship with the novel
SARS-CoV-2. |
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Beaudry, MeganS, Frederick, et al |
medRxiv |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
To address the shortage of N95 respirators, innovative methods are needed to decontaminate coronaviruses from N95 respirators,
allowing them to be safely reused by healthcare workers. For this research, we use a commercial ozone disinfecting cabinet to examine the efficacy of ozone-based disinfection of a conservative surrogate virus for SARS-CoV-2, the MS2 bacteriophage. Treatment
of mask materials with enhanced ozone treatment resulted in 2.38-log 10 (>99%) reduction of phage from household dust masks and a range of 1.43-log 10 (96.2%) to 4-log 10 (99.99%) reductions of phage from common N95 mask materials. |
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Bellino, S, Rota, et al |
Pediatrics |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of the present study is to evaluate, before school starts, the impact of the transition phase (the progressive
reopening of all activities starting from May 4th to September 13th) of the epidemic on pediatric cases. As of September 13th, 2020, 9,868 pediatric COVID-19 cases have been reported in Italy, that represent 3.4% of all Italian cases. However, the rate of
cases in children and adolescents has sharply increased since the beginning of the transition phase (May 4th), from 1.8% during the lockdown to 8.5% (6,197/73,206) during the post-lockdown phase. |
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Bellissimo, N, Gabay, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
Public compliance with social distancing is key to containing COVID-19, yet there is a lack of knowledge on which communication
'messages' drive compliance. Respondents (224 Canadians and Americans) rated combinations of messages about compliance, systematically varied by an experimental design. Independent variables were perceived risk; the agent communicating the policy; specific
social distancing practices; and methods to enforce compliance. Response patterns to each message suggest three mindset segments in each country reflecting how a person thinks. Two mindsets, the same in Canada and the US, were 'tell me exactly what to do,'
and 'pandemic onlookers.' The third was 'bow to authority' in Canada, and 'tell me how' in the US. Each mindset showed different messages strongly driving compliance. |
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Benea, Carla, Rendon, et al |
medRxiv |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
This study evaluated the negative predictive value (NPV) of a home-based 7-day infection control strategy. HCWs advised
by their Infection Control or Occupational Health officer to self-isolate due to a high-risk SARS-CoV-2 exposure were enrolled between May-September 2020. The strategy consisted of symptom-triggered nasopharyngeal SARS-CoV-2 RNA testing from day 0-6 post exposure,
followed by standardized home-based nasopharyngeal swab and saliva testing on day 7. Among 30 HCWs enrolled to date (age 31±9 years, 24 80.0%] female), 3 were diagnosed with COVID-19 by day 14 post exposure (secondary attack rate 10.0%), with all cases detected
by the 7-day infection control strategy: NPV for subsequent clinical COVID-19 or asymptomatic SARS-CoV-2 detection by day 14 was 100.0% (95% CI: 93.1-100.0%). |
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Bharadwaj, S, Azhar, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Herein, we employed computationally screening of Druglib database containing FDA approved drugs against active pocket
of SARS-CoV-2 M(pro) using MTiopen screen web server, yields a total of 1051 FDA approved drugs with docking energy >-7 kcal/mol. The top 10 screened potential compounds against SARS-CoV-2 M(pro) were then studied by re-docking, binding affinity, intermolecular
interaction, and complex stability via 100 ns all atoms molecular dynamics (MD) simulation followed by post-simulation analysis, including end point binding free energy, essential dynamics, and residual correlation analysis against native crystal structure
ligand N3 inhibitor. Based on comparative molecular simulation and interaction profiling of the screened drugs with SARS-CoV-2 M(pro) revealed R428 (-10.5 kcal/mol), Teniposide (-9.8 kcal/mol), VS-5584 (-9.4 kcal/mol), and Setileuton (-8.5 kcal/mol) with stronger
stability and affinity than other drugs and N3 inhibitor; and hence, these drugs are advocated for further validation using in vitro enzyme inhibition and in vivo studies against SARS-CoV-2 infection. |
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Billings, Jo, Abou Seif, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
We set out by qualitatively exploring UK frontline health and social care workers own experiences and views of psychosocial
support during the pandemic. We conducted 25 interviews with frontline workers from a variety of professional groups working in health and social care settings across the UK. Themes derived from our analysis showed that workers experiences and views about
psychosocial support were complex. Peer support was many workers first line of support but could also be experienced as a burden. Workers were ambivalent about support shown by organisations, media and the public. Whilst workers valued psychological support
services, there were many disparities in provision and barriers to access. The results of this study show that frontline health and social care workers are likely to need a flexible system of support including peer, organisational and professional support. |
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Comparison of SARS-CoV-2 infection in two non-human
primate species: rhesus and cynomolgus macaques |
Boszormenyi, KingaP, Stammes, et al |
bioRxiv |
Clinical data| Données cliniques Animal model | Modèle animal |
Here, we directly compared the course of SARS-CoV-2 infection in the two genetically closely-related macaque species.
After inoculation with a low passage SARS-CoV-2 isolate, clinical, virological, and immunological characteristics were monitored. Both species showed slightly elevated body temperatures in the first days after exposure while a decrease in physical activity
was only observed in the rhesus macaques and not in cynomolgus macaques. The virus was quantified in tracheal, nasal, and anal swabs, and in blood samples by qRT-PCR, and showed high similarity between the two species. Consequently, we concluded that both
rhesus and cynomolgus macaques represent valid models for evaluation of COVID-19 vaccine and antiviral candidates in a preclinical setting. |
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Caselli, E, Soffritti, et al |
Biology (Basel) |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Our study was thus aimed to analyze the presence of secretory mucosal anti-SARS-CoV-2 type A immunoglobulins (IgA)
in the conjunctival fluid of COVID-19 patients. The tears of 28 COVID-19 patients and 20 uninfected controls were collected by the Schirmer test and analyzed by a specific ELISA assay detecting anti-spike (S1) virus protein IgA. The results showed that 35.7%
of COVID-19 subjects have specific antiviral IgA at the ocular level, persisting till 48 days post disease onset. Most of the IgA positive subjects presented mild symptoms. |
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SARS-CoV-2 Related Encephalitis: MRI Pattern of the Olfactory Tract Involvement |
Casez, O, Willaume, et al |
Neurology |
Clinical data| Données cliniques |
Case report of a 96 year old female with SARS-CoV-2 related encephalitis. |
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The impact of COVID-19 among Black women: evaluating perspectives and sources
of information |
Chandler, R, Guillaume, et al |
Ethn Health |
Public Health response| Interventions de santé publique |
DESIGN: We conducted interviews with 15 Black women who are clients at a community-based family service center to assess
their understanding of COVID-19, determine how they were obtaining COVID-19 information, and evaluate the various impacts that COVID-19 was having on their lives. RESULTS: The majority of participants were using a combination of social media platforms and
news sources to obtain information about COVID-19. Most participants (79%) expressed confusion, misunderstanding, and mistrust of the information that they were receiving about COVID-19. |
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Safety of patients and providers in lung cancer surgery during the COVID-19 pandemic |
Chang, SH, Zervos, et al |
Eur J Cardiothorac Surg |
Healthcare Response | Réponse des soins de santé |
The primary objectives of this study are to evaluate the safety of patients who have undergone pulmonary resection
for lung cancer as well as provider safety, using COVID-19 testing, symptoms and early patient outcomes. METHODS: Patients with confirmed or suspected pulmonary malignancy who underwent resection from 13 March to 4 May 2020 were retrospectively reviewed. RESULTS:
Between 13 March and 4 May 2020, 2087 COVID-19 patients were admitted. None of the patients developed major complications, 5 had minor complications, and the median length of hospital stay was 2 days. No previously COVID-19-negative patient or healthcare
providers developed symptoms of or tested positive for COVID-19. |
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Chen, J, Wu, et al |
Sci Rep |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We aimed to construct a system based on deep learning for detecting COVID-19 pneumonia on high resolution CT. For model
development and validation, 46,096 anonymous images from 106 admitted patients, including 51 patients of laboratory confirmed COVID-19 pneumonia and 55 control patients of other diseases in Renmin Hospital of Wuhan University were retrospectively collected.
The model achieved a per-patient accuracy of 95.24% and a per-image accuracy of 98.85% in internal retrospective dataset. |
|
|
Exploring diversity of covid-19 based on substitution distance |
Chen, YH, Wang, et al |
Infection and Drug Resistance |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
To explore the diversity of SARS-CoV-2, we use different nucleotide substitution models to calculate the distances
of SARS-CoV-2 samples from 3 different areas, China, Europe, and the USA. Then, we use these distances to infer the origin of COVID-19. Results: It is known that COVID-19 originated in Wuhan China and then spread to Europe and the USA. By using different substitution
models, the distances of SARS-CoV-2 samples from these areas are significantly different. The analyzed results in most substitution models show that China has the lowest diversity, followed by Europe and lastly by the USA. This outcome coincides with the virus
transmission time order that SARS-CoV-2 starts in China, then outbreaks in Europe and finally in the USA. |
|
Coyle, C, Ghazi, et al |
Ir J Med Sci |
Mental Health |
|
We aimed to identify the activities respondents found beneficial for their well-being and mental health and recorded
a mood score from survey respondents. METHODS: A nationwide study was completed to investigate the mental health impact of the COVID-19 pandemic upon medical students and newly qualified doctors (interim foundation year one). We received 2075 respondents from
across the UK. RESULTS: Physical activity was found to be the most common activity used by the survey respondents to help with their mental well-being (80.1%) (medical students, 83.7%; interim foundation doctors, 72.3%). Participants who stated that exercise
helped their well-being had a mean score which was significantly higher than those who reported that they did not exercise. Respondents who stated they had used exercise to help with their mental well-being had (on average) a higher mood score than those who
did not. |
|
|
Daoud, S, Alabed, et al |
Acta Pharm |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study, the recently resolved X-ray crystallographic structure of COVID-19 main protease (Mpro) was used to
generate a pharmacophore model and to conduct a docking study to capture antiviral drugs as new promising COVID-19 main protease inhibitors. The developed pharmacophore successfully captured five FDA-approved antiviral drugs (lopinavir, remdesivir, ritonavir,
saquinavir and raltegravir). The five drugs were successfully docked into the binding site of COVID-19 Mpro and showed several specific binding interactions that were comparable to those tying the co-crystallized inhibitor X77 inside the binding site of COVID-19
Mpro. Three of the captured drugs namely, remdesivir, lopinavir and ritonavir, were reported to have promising results in COVID-19 treatment and therefore increases the confidence in our results. |
|
|
De Meester, J, De Bacquer, et al |
J Am Soc Nephrol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
METHODS: To describe the incidence, characteristics, and outcomes of SARS-CoV-2 infection, we conducted a prospective,
multicenter, region-wide registry study in adult patients on RRT versus the general population from March 2 to May 25, 2020. This study comprised all patients undergoing RRT in the Flanders region of Belgium, a country that has been severely affected by coronavirus
disease 2019 (COVID-19). RESULTS: We found no excess mortality in the hemodialysis population when compared with mean mortality rates during the same 12-week period in 2015-2019 because COVID-19 mortality was balanced by lower than expected mortality among
uninfected patients. Mortality associated with SARS-CoV-2 infection is high in patients on RRT. |
|
|
Desai, A, Santonocito, et al |
Medicina (Lithuania) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study is to assess the effectiveness of Streptococcus pneumoniae u-Ag testing in coronavirus disease
2019 (COVID-19) patients, in order to assess whether pneumococcal co-infection is associated with different mortality rate and hospital stay in these patients. Materials and Methods: Charts, protocols, mortality, and hospitalization data of a consecutive series
of COVID-19 patients admitted to a tertiary hospital in northern Italy during COVID-19 outbreak were retrospectively reviewed. All patients underwent Streptococcus pneumoniae u-Ag testing to detect an underlying pneumococcal co-infection. Results: All u-Ag+
patients underwent treatment with Ceftriaxone and Azithromycin or Levofloxacin. All u-Ag+ patients were hospitalized. Mortality was 15.4% and 25.9% in u-Ag+ and u-Ag-patients, respectively. Survival analysis showed a better prognosis, albeit not significant,
in u-Ag+ patients. he routine use of Streptococcus pneumoniae u-Ag testing helped to better target antibiotic therapy with a final trend of reduction in mortality of u-Ag+ COVID-19 patients having a concomitant pneumococcal infection. |
|
|
Logistic growth model and modeling of factors for community case transmission |
Diouf, Massamba, Ndiaye, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission |
In this article, we analyze the spread of cases resulting from community transmission of COVID-19 in Senegal in order
to identify statistical associations. The identification and knowledge of the factors associated with this community transmission can be a decision support tool to limit the spread of the disease. We estimate parameters and evaluate the growth factor, community
rate, weekly increase and daily difference, and make forecasting to help on how to find concrete actions to control the situation. |
|
Modeling the Impact of Unreported Cases of the COVID-19 in the North African Countries |
Djilali, S, Benahmadi, et al |
Biology (Basel) |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Authors study a mathematical model investigating the impact of unreported cases of the COVID-19 in three North African
countries: Algeria, Egypt, and Morocco. They suggest some additional measures that can be considered to reduce the burden of the COVID-19 and would lead to a second wave of the spread of the virus in these countries. |
|
Dong, QQ, Qiu, et al |
Current Medical Science |
Transmission Clinical data| Données cliniques |
Authors explore whether kindergartens reopening will increase the risk of severe acute respiratory syndrome coronavirus
2 spread. They reviewed two pediatric patients with moderate COVID-19, collected the epidemiologic information and monitored the cycle threshold value of rectal specimen and the viral loads, and discussed the transmission of SARS-CoV-2 in pediatric patients
and the virulence of feces in children with moderate COVID-19, in order to analyze the risk of kindergartens reopening |
|
|
Anxiety and Depression Symptoms in COVID-19 Isolated Patients and in Their Relatives |
Dorman-Ilan, S, Hertz-Palmor, et al |
Frontiers in Psychiatry |
Mental Health |
|
The aim of this study was to measure anxiety and depression, and to assess their association with socio-demographic
and pandemic-related stress factors in COVID-19 patients and their relatives during the initial stage of hospitalization. Patients and relatives experience similar high anxiety levels which are more robust in women and lower in ultra-orthodox participants. |
|
Telemedicine Usage Among Urologists During the COVID-19 Pandemic: Cross-Sectional Study |
Dubin, JM, Wyant, et al |
J Med Internet Res |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to investigate current telemedicine usage by urologists, urologists' perceptions on the necessity
of in-person clinic appointments, the usability of telemedicine, and the current barriers to its implementation. In the face of this pandemic, urologists' usage of telemedicine nearly tripled, demonstrating their ability to adopt and adapt telemedicine into
their practices, but barriers involving the technology itself are still preventing many from utilizing it despite increasing interest. |
|
Fan, S, Wu, et al |
Frontiers in Public Health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
This study describes a novel strategy for preventing and controlling COVID-19 infection in the third-tier city of Liaocheng,
China. The strategies of this third-tier Chinese city provide useful insights into approaches to prevent and control COVID-19 spread in other Chinese cities and countries. |
|
|
Clinical characteristics and treatment strategies of 79 patients with
COVID-19 |
Fang, XW, Mei, et al |
Chinese Pharmacological Bulletin |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The aim of this paper was to analyze the clinical characteristics of patients of corona virus disease 2019 (COVID-19),
and summarize the treatment experience, aiming to provide diagnostic and treatment reference for the front-line clinicians. The elderly patients with multiple cardiovascular diseases are more likely to get severe and critical COVID-19. |
|
Feldman, Mitra, Lacey Krylova, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
Authors surveyed healthcare workers (HCWs) in Mozambique to determine their knowledge, attitudes and practices (KAP)
in relation to the COVID-19 pandemic. The results from the survey were used to support the rapid development and deployment of targeted COVID-19 awareness and education materials for the agentes polivalentes elementares (APEs), as HCW are known as in Mozambique. |
|
|
Fisher, KA, Olson, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
A case-control investigation was conducted to compare telework between eligible symptomatic persons who received positive
SARS-CoV-2 RT-PCR test results (case-patients, 153) and symptomatic persons with negative test results (control-participants, 161). Among employed participants who reported on their telework status during the 2 weeks preceding illness onset (248), the percentage
who were able to telework on a full- or part-time basis was lower among case-patients (35%; 42 of 120) than among control-participants (53%; 68 of 128) (p<0.01). Case-patients were more likely than were control-participants to have reported going exclusively
to an office or school setting (aOR = 1.8; 95% CI] = 1.2-2.7) in the 2 weeks before illness onset. The association was also observed when further restricting to the 175 participants who reported working in a profession outside the critical infrastructure(†)
(aOR = 2.1; 95% CI = 1.3-3.6). |
|
|
Foye, Una, Dalton-Locke, et al |
medRxiv |
Mental Health |
|
This paper aims to explore how Covid-19 has affected the ability of mental health nurses to deliver care in community
and inpatient mental health services in the UK. The findings identify areas requiring attention and investment to prepare for future crises and the consequences of the pandemic. |
|
|
Biometric covariates and outcome in COVID-19 patients:
Are we looking close enough? |
Fritsch, Sebastian Johannes, Sharafutdinov, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to get a more detailed insight into the influence of biometric covariates on the outcome
of COVID-19 patients with high degree of severity. Authors found that survival in mechanical ventilation is affected by complex interactions of covariates differing to the reported covariates, which are hidden in generic, non-stratified studies on risk factors |
|
Prediction of Personal Protective Equipment Use in Hospitals During COVID-19 |
Furman, Eugene, Cressman, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins
de santé |
This Canadian study proposes an approach to predict demand for PPE. Specifically, we model the admission of patients
to a medical department using multiple independent queues. Each queue represents a class of patients with similar treatment plans and hospital length-of-stay. By estimating the total workload of each class, we derive closed-form estimates for the expected
amount of PPE required over a specified time horizon using current PPE guidelines. We apply our approach to a data set of 22,039 patients admitted to the general internal medicine department at St. Michael's hospital in Toronto, Canada from April 2010 to November
2019. We find that gloves and surgical masks represent approximately 90% of predicted PPE usage. We also find that while demand for gloves is driven entirely by patient-practitioner interactions, 86% of the predicted demand for surgical masks can be attributed
to the requirement that medical practitioners will need to wear them when not interacting with patients. |
|
Gao, B, Zhai, et al |
|
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
Based on the analysis of the existing historical data, this paper predicts the number of people who return to work
through intelligent algorithm, so that the government can prepare and distribute epidemic prevention materials. Based on the analysis of the daily power consumption data of the enterprise, combined with the existing number of enterprises returning to work,
this paper constructs a prediction model of the number of enterprises returning to work, and completes the prediction of the number of enterprises returning to work in the future. The experimental results based on the simulation data of the number of enterprises
returning to work with different distributions show that the intelligent algorithm can effectively predict the number of enterprises returning to work under the background of COVID-19. |
|
|
The impact of individual lifestyle and status on the acquisition of COVID-19:
A case-Control study |
Gao, C, Zhao, et al |
PLoS One |
Epidemiology| Épidémiologie |
This study aimed to see whether there is an association between lifestyle behaviors and the acquisition of COVID-19.
A total of 105 patients diagnosed with COVID-19 and 210 controls were included. Compared with control group, the case group had higher proportions of lack of sleep (30.5% vs. 14.8%, P = 0.001) and increased physical activities (56.2% vs. 32.9%, P < 0.001).
And patients in the case group were more likely to have alopecia (28.6% vs. 10.0%, P < 0.001) than people from the control group. Overall, we found that lack of sleep adjusted odds ratio (OR) 1.56, 95% confidence interval (CI) 1.03-2.39)], physical activities
(≥ 5 times a week) (adjusted OR 2.05, 95%CI 1.39-3.02) and alopecia (adjusted OR 1.73, 95%CI 1.13-2.66) were independent risk factors for COVID-19 infection. Conversely, low-dose alcohol intake (<100g alcohol per week), hand hygiene, and fruits intake (daily)
were significantly associated with a decrease in morbidity. |
|
Gisby, Jack, Clarke, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We performed dense serial blood sampling in hospitalised and non-hospitalised end-stage kidney disease (ESKD) patients
with COVID-19, and used Olink immunoassays to measure 436 circulating proteins. Comparison to 51 non-infected ESKD patients revealed 221 proteins differentially expressed in COVID-19, of which 69.7% replicated in an independent cohort of 46 COVID-19 patients.
203 proteins were associated with clinical severity scores, including IL6, markers of monocyte recruitment, neutrophil activation and epithelial injury. Random Forests machine learning identified predictors of current or future severity. Survival analysis
with joint models revealed 69 predictors of death. Finally, longitudinal modelling with linear mixed models uncovered 32 proteins that display different temporal profiles in severe versus non-severe disease, including integrins and adhesion molecules. |
|
|
Transmission of SARS-COV-2 Infections in Households - Tennessee and Wisconsin,
April-September 2020 |
Grijalva, CG, Rolfes, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Transmission |
Study on household transmission of SARS-CoV-2 in Nashville, Tennessee and Marshfield, Wisconsin. Index patients and
household members completed symptom diaries and self-collected specimens, nasal swabs only or nasal swabs and saliva samples, daily for 14 days. Specimens from the first 7 days were tested for SARS-CoV-2 using CDC RT-PCR protocols. A total of 191 enrolled
household contacts of 101 index patients reported having no symptoms on the day of the associated index patient's illness onset, and among these 191 contacts, 102 had SARS-CoV-2 detected in either nasal or saliva specimens during follow-up, for a secondary
infection rate of 53%. Among fourteen households in which the index patient was aged <18 years, the secondary infection rate from index patients aged <12 years was 53% and from index patients aged 12-17 years was 38%. Approximately 75% of secondary infections
were identified within 5 days of the index patient's illness onset, and substantial transmission occurred whether the index patient was an adult or a child. Because household transmission of SARS-CoV-2 is common and can occur rapidly after the index patient's
illness onset, persons should self-isolate immediately at the onset of COVID-like symptoms, at the time of testing as a result of a high risk exposure, or at the time of a positive test result, whichever comes first. |
|
Gunda, Shravan Kumar, KumariP, et al |
Research Square prepub |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
To identify the potential inhibitors, we have performed molecular docking against the SARS-CoV-2 main protease (6Y84)
with fifteen important natural xanthone compounds. The docking results showed all the compounds exhibited good binding energies and interactions with the main protease. The validation of representative docking complexes through molecular dynamics simulations
showed that xanthones binds with a higher binding affinity and lower free energy than the standard ligand with Brasixanthone C and Brasixanthone B on 50 ns. Natural xanthone compounds have also passed the Absorption, Distribution, Metabolism, and Excretion
(ADME) property criteria as well as Lipinski’s rule of five. The present integrated molecular docking and dynamics simulations study unveil the use of xanthones as potential antiviral agents against SARS-CoV-2. |
|
|
These Unprecedented Times: The Dynamic Pattern Of COVID-19 Deaths Around The World |
Han, Zixuan, Li, et al |
arXiv |
Epidemiology| Épidémiologie |
In this article, we deal with COVID-19 data to study the trend of the epidemic at the global situation. Choosing the
mortality rate as an appropriate metric which measures the relative relation between the cumulative confirmed cases and death cases, we utilize the modified kernel estimator for random density function (Petersen and Muller, 2016) to obtain the density of the
mortality rate, and apply Frechet change point detection (Dubey and Muller, 2020) to check if there is any significant change on the dynamic pattern of COVID-19 deaths. The analysis shows that the pattern of global COVID-19 mortality rate seems to have an
obvious change at 104 days after first day when the reported death cases exceed 30. Then we discuss the reasons of abrupt change of mortality rate trend from aspects both subjective and objective. |
|
Hang, Jun, Li, et al |
bioRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The long-lasting global COVID-19 pandemic demands timely genomic investigation of SARS-CoV-2 viruses. Here we report
a simple and efficient workflow for whole genome sequencing utilizing one-step RT-PCR amplification on a microfluidic platform, followed by MiSeq amplicon sequencing. The method uses Fluidigm IFC and instruments to amplify 48 samples with 39 pairs of primers
in a single step. Application of this method on RNA samples from both viral isolate and clinical specimens demonstrate robustness and efficiency of this method in obtaining the full genome sequence of SARS-CoV-2. |
|
|
He, F, Ding, et al |
Canadian Journal of Infectious Diseases and Medical Microbiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to explore the clinical characteristics of patients with different severity in the early outbreak
of COVID-19, hoping to provide reference for clinical diagnosis and treatment. We retrospectively analyzed the clinical data of 95 COVID-19 patients in Wuhan Red Cross Hospital of China from January 17 to February 13, 2020. Outcomes were followed up until
April 1, 2020. Clinical classification included 54 cases of common type, 27 cases of severe type, and 14 cases of critical type. Study reports on common symptoms, laboratory abnormalities, chest CT findings. Severe and critical cases were older, more likely
to have shortness of breath, more likely to have underlying comorbidities, and more likely to have abnormal laboratory findings than common cases. All common and severe patients were cured and discharged from the hospital, while 10 (71.4%) of 14 critical patients
died. |
|
|
33091154; Vaccine design based on 16 epitopes of SARS-CoV-2 spike protein |
He, J, Huang, et al |
Journal of medical virology |
Vaccine Research| Recherche sur les vaccins |
In this study, 66 epitopes containing pentapeptides of SARS-CoV-2 spike protein in the IEDB database were compared
with the amino acid sequence of SARS-CoV-2 spike protein, and 66 potentially immune-related peptides of SARS-CoV-2 spike protein were obtained.The best candidate epitopes were identified and connected by different linkers in silico to obtain vaccine candidate
sequences. The results showed that 16 epitopes were relatively conservative, immunological, nontoxic, and nonallergenic, could induce the secretion of cytokines, and were more likely to be exposed on the surface of the spike protein. They were both B- and
T-cell epitopes, and could recognize a certain number of HLA molecules and had high coverage rates in different populations. Moreover, epitopes 897-913 were predicted to have possible cross-immunoprotection for SARS-CoV and SARS-CoV-2. The results of vaccine
candidate sequences screening suggested that sequences (without linker, with linker GGGSGGG, EAAAK, GPGPG, and KK, respectively) were the best. |
|
Hirschman, J, Kaur, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
Description of an outbreak of 27 cases in a Hopi Tribe in the USA, resulting from two co-index cases. |
|
|
Ho, FK, Petermann-Rocha, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study explored the factors mediating the association of whether older age was associated with increased mortality
risk in the absence of other risk factors. Current age was associated exponentially with COVID-19 mortality. Overall, participants aged ≥75 years were at 13-fold (95% CI 9.13–17.85) mortality risk compared with those <65 years. Low forced expiratory volume
in 1 second, high systolic blood pressure, low handgrip strength, and multiple long-term conditions were significant mediators, and collectively explained 39.3% of their excess risk. The associations between these risk factors and COVID-19 mortality were stronger
among older participants. Participants aged ≥75 without additional risk factors were at 4-fold risk (95% CI 1.57–9.96, P = 0.004) compared with all participants aged <65 years. |
|
|
Parental perceptions of COVID-19-like illness in
their children |
Hodson, Ava, Woodland, et al |
medRxiv |
Public Health response| Interventions de santé publique |
This study aims to explore parents’ perceptions of COVID-19-like symptoms in their child and attitudes towards isolating
from others in the household when unwell. We found four themes relating to symptom attribution (‘normalising symptoms’, ‘err on the side of caution’, ‘experience of temperature’, ‘symptoms not normal for us’). In general, parents were more likely to attribute
symptoms to COVID-19 if a temperature was present or the symptoms were perceived as ‘unusual’ for their family. Four themes relating to self-isolation (‘difficult to prevent contact with children’, ‘isolation would be no different to lockdown life’, ‘ability
to get food and supplies’, ‘limited space’). Parents believed they would find isolation within the household difficult or impossible if they had dependent children, had limited space or could not shop for groceries. |
|
Frequent testing and immunity-based staffing will
help mitigate outbreaks in nursing home settings |
Holmdahl, Inga, Kahn, et al |
medRxiv |
Public health interventions*| Interventions de santé publique |
We aimed to evaluate the reduction in transmission in nursing homes achieved through contact-targeted interventions
and testing and to evaluate the effectiveness of two types of screening tests conducted with varying frequency: 1) rapid antigen testing and 2) PCR testing. Findings show that the frequency and type of testing has a larger impact on the size of outbreaks
than the cohorting and staffing interventions. The most effective testing strategies modeled are daily antigen testing of everyone and daily antigen testing of staff with weekly PCR testing for residents. Under all screening testing strategies, the immunity-based
staffing intervention reduces the final size of the outbreak. The resident cohorting intervention reduces the final outbreak size under some, but not all, testing scenarios. |
|
Huh, K, Jung, et al |
Clin Infect Dis |
Public health interventions*| Interventions de sant&eacute; publique |
BACKGROUND: Many countries have implemented non-pharmaceutical interventions (NPIs) to slow the spread of coronavirus
disease 2019 (COVID-19). We aimed to determine whether NPIs led to the decline in the incidences of respiratory infections. METHODS: We conducted a retrospective, ecological study using a nationwide notifiable diseases database and a respiratory virus sample
surveillance collected from January 2016 through July 2020 in the Republic of Korea. Intervention period was defined as February-July 2020, when the government implemented NPIs nationwide. Observed incidences in the intervention period were compared to the
predicted incidences by autoregressive integrated moving average model and the 4-year mean cumulative incidences (CuIs) in the same months of the pre-intervention period. RESULTS: Five infectious diseases met the inclusion criteria: chickenpox, mumps, invasive
pneumococcal disease, scarlet fever, and pertussis. The incidences of chickenpox and mumps during the intervention period were significantly lower than the prediction model. The CuIs of chickenpox and mumps were 36.4% (95% CI, 23.9-76.3) and 63.4% (95% CI,
48.0-93.3) of the predicted values. Subgroup analysis showed that the decrease in the incidence was universal for chickenpox, while mumps showed a marginal reduction among those aged <18 years, but not in adults. The incidence of respiratory viruses was significantly
lower than both the predicted incidence (19.5%; 95% CI, 11.8-55.4%) and the 4-year mean CuIs in the pre-intervention period (24.5%; P<0.001). CONCLUSIONS: The implementation of NPIs was associated with a significant reduction in the incidences of several respiratory
infections in Korea. |
|
|
Effect of COVID-19 on delivery plans and postnatal depression scores of pregnant women |
Hui, PW, Ma, et al |
Hong Kong Med J |
Mental Health |
|
The aim of the present study was to investigate the effects of these restrictive measures on delivery plans and risks
of postpartum depression in Hong Kong. The delivery rate at a public hospital was reduced during the coronavirus disease 2019 (COVID-19) pandemic. Women who delivered in the public hospital had higher Edinburgh Postnatal Depression Scale scores during the
coronavirus alert period. A lower rate of non-pharmacological pain relief and a higher rate of pethidine usage were observed during labour. |
|
Don't wait, re-escalate: delayed action results in
longer duration of COVID-19 restrictions |
Hurford, Amy, Watmough, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
Assuming that interventions are sufficient to reduce infection prevalence, we use a simple linear SIR model with case
importation to determine the relationship between the timing of restrictions, duration of measures necessary to return the incidence to a set point, and the final size of the outbreak. The predictions of our linear SIR model agree well with COVID-19 data from
Atlantic Canada, and are consistent with the predictions of more complex deterministic COVID-19 models. We conclude that earlier re-escalation of restrictions results in shorter disruptions, smaller outbreaks, and consequently, lower economic and social costs.
Our key message is succinctly summarized as `don't wait, re-escalate' since delaying re-escalation of restrictions results in not only in more infections, but also longer periods of restrictions. |
|
Hussain, I, Majeed, et al |
PLoS One |
Healthcare Response | Réponse des soins de santé |
To evaluate the pharmacist’s preparedness against the COVID-19 during its rapid rise period in Pakistan, an online
cross-sectional study was carried out from March 30 to May 22, 2020. The mean COVID-19 knowledge score of the participants was 6.77±0.5, which indicated that 84% of them had good knowledge about COVID-19. The multiple linear regression model revealed that
attitude was significantly associated with gender (p = 0.001), marital status (p<0.0001) and resident (p = 0.013). The mean practice score was 2.85±0.4, showing that 94% of the participants were following adequate preventive practices against this infection.
The results from this study suggest that Pharmacists demonstrated good knowledge, positive attitudes, and acceptable practices regarding COVID-19. |
|
|
Jasser, RA, Sarhan, et al |
Journal of Multidisciplinary Healthcare |
Healthcare Response | Réponse des soins de santé |
The aim of the study was to determine the level of awareness among the dental students in Saudi Arabia regarding COVID-19.
A mean score of 2.31± 0.32 was recorded for level of knowledge among the dental professionals that indicated a fair level of knowledge among the participants. Similarly, a mean score of 6.5± 0.45 was recorded for attitude of dental professionals towards COVID-19
that indicated a moderate level of attitude. “Novel COVID-19 virus transmits through droplets,” and “masks should be worn most of the time to prevent infection spread,” had the lowest correct answer rates. The practice had a low mean score of 0.81± 0.22. The
results depicted statistically significant differences in knowledge, with postgraduate students having the highest mean scores, followed by interns and undergraduate students. |
|
|
Jereczek-Fossa, B, Pepa, et al |
Med Oncol |
Healthcare Response | Réponse des soins de santé |
The present survey study, endorsed by CODRAL and AIRO-L, aimed to assess how radiotherapy (RT) departments in Lombardy
have dealt with the recovery. The study revealed a particular attention to anti-contagion measures and a return to normal or even higher clinical workload in most RT centres in Lombardy, necessary to carry out current and previously deferred treatments. |
|
|
Kırbıyık, U, Binder, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie |
Network analyses and visualization can provide information about outbreak transmission dynamics. Analysis of detained
person and staff member movements during a COVID-19 outbreak at Cook County Jail in Illinois found fewer connections among detained persons with COVID-19 than expected, suggesting that interventions and medical isolation practices were effective at reducing
transmission. Higher than expected connections were identified in staff member networks, suggesting occurrence of additional transmission and areas of focus for transmission interruption. A network-informed approach can identify likely points of high transmission,
enabling targeted interventions to reduce transmission, such as by reducing convening of staff members, closing breakrooms, and cessation of contact sports. |
|
|
Kousar, K, Majeed, et al |
BioMed Research International |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Herein, we have targeted two nonstructural proteins of SARS-CoV-2, namely, methyltransferase (nsp16) and helicase (nsp13),
respectively, due to their substantial activity in viral pathogenesis. A total of 2035 compounds were analyzed for their pharmacokinetics and pharmacological properties. It is concluded that EryvarinM, Silydianin, Osajin, and Raddeanine can be considered potential
inhibitors for MTase, while TomentodiplaconeB, Osajin, Sesquiterpene Glycoside, Rhamnetin, and Silydianin for helicase. |
|
|
Kubo, Sousuke, Ohtake, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We have developed a high-throughput serological test capable of simultaneously detecting total Ig and IgG against two
of the most immunologically relevant SARS-CoV-2 antigens, nucleocapsid protein (NP) and spike protein (SP) and report its performance in detecting COVID-19 in clinical samples. We determined the basal thresholds based on 17 sera obtained from confirmed COVID-19
patients and 600 negative sera. We evaluated the clinical validity of the assay. Results: All of the four test parameters showed 100% specificity individually. The sensitivity of the assay increased proportionally to the elapsed time from symptoms onset, and
all the tests achieved 100% sensitivity after 13 days from symptoms onset. |
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|
Kulasinghe, Arutha, Tan, et al |
medRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Here, we use spatial transcriptomics to generate an in-depth picture of the pulmonary transcriptional landscape of
COVID-19 (10 patients), pandemic H1N1 (pH1N1) influenza (5) and uninfected control patients (4). Host transcriptomics showed a significant upregulation of genes associated with inflammation, type I interferon production, coagulation and angiogenesis in the
lungs of COVID-19 patients compared to non-infected controls. SARS-CoV-2 was non-uniformly distributed in lungs with few areas of high viral load and these were largely only associated with an increased type I interferon response. A very limited number of
genes were differentially expressed between the lungs of influenza and COVID-19 patients. Specific interferon-associated genes (including IFI27) were identified as candidate novel biomarkers for COVID-19 differentiating this COVID-19 from influenza. Collectively,
these data demonstrate that spatial transcriptomics is a powerful tool to identify novel gene signatures within tissues, offering new insights into the pathogenesis of SARS-COV-2 to aid in patient triage and treatment. |
|
|
Lackner, ChristineL, Wang, et al |
medRxiv |
Public Health response| Interventions de santé publique |
In this exploratory study, we investigated the demographic, experiential, and psychological factors associated with
the anticipated likelihood and speed of having children receive a SARS-CoV-2 vaccine in a sample of 455 Canadian families (857 children). Using linear mixed effects and proportional odds logistic regression models, we demonstrated that older parental age,
living in the Prairies (relative to Central Canada), more complete child and parental vaccination history, more positive attitudes towards vaccines generally, higher psychological avoidance of the pandemic and a greater tendency to prioritize the risks of
the disease relative to the risks of side effects (i.e., lower omission bias), were associated with higher likelihoods of intention to vaccinate participants' children. In some models, subjective evaluations of proximal COVID-19 risk and higher levels of state
anxiety were associated with increased likelihood of having children vaccinated. |
|
|
Lahat, A, Benjamin, et al |
Clin Endosc |
Healthcare Response | Réponse des soins de santé |
Our aim was to review the policies enacted during this outbreak and study their influence on the performance of endoscopic
procedures. METHODS: Following the revision of work protocols, personnel were divided into two permanent and physically separate working groups and screening procedures were rescheduled. The study included data for January-March 2018-2020, and a comparison
among the data from each year was performed. RESULTS: As of March 2020, the total number of endoscopic examinations performed reduced by 44% (p<0.0001) as compared to previous years, gastroscopy examinations reduced by 39% , and lower endoscopy procedures
reduced by 57%. |
|
|
Lalot, F, Heering, et al |
Group Processes and Intergroup Relations |
Public Health response| Interventions de santé publique |
The present study focuses on the role of concern and political trust in people’s willingness to comply with governmental
restrictions during the Covid-19 pandemic. We conducted a survey amongst Italian and French participants (N = 372) in March 2020 while both countries had imposed full lockdown. Moreover, a subsample of participants reported on their actual levels of compliance
one week later (N = 130). We hypothesised that either concern or trust should be sufficient to sustain participants’ willingness to comply and actual behaviour, but that the absence of both (distrustful complacency) would reduce compliance significantly. Results
supported this hypothesis. We discuss implications of the interaction between concern and trust for public behaviour strategies as the pandemic progresses. |
|
|
Lazarević, M |
Medicinski Casopis |
Mental Health |
|
The aim of the study was to determine the degree of anxiety among medical workers employed in the city of Loznica and
suburban municipalities at the time of the COVID-19 pandemic. The analysis of the results yielded a mean value of the Beck test for the assessment of fear and anxiety of 6.82 (standard deviation 7.49, rank 0-39), which represents a state of anxiety without
clinical significance. |
|
|
Lee, J, Venugopal, et al |
Int J Environ Res Public Health |
Healthcare Response | Réponse des soins de santé |
We assessed the knowledge, attitudes, and practices of HCWs from India and Singapore regarding PPE usage and heat stress
when performing treatment and care activities. One hundred sixty-five HCWs from India (n = 110) and Singapore (n = 55) participated in a survey. HCWs are cognizant of the effects of heat stress but might not adopt best practices due to various constraints.
Thermal stress management is better in Singapore than in India. Ice slurry ingestion is shown to be practical and effective in promoting thermal comfort. |
|
|
Model Calculations of Aerosol Transmission and Infection Risk of COVID-19 in Indoor
Environments |
Lelieveld, J, Helleis, et al |
Int J Environ Res Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission
Public health interventions*| Interventions de sant&eacute; publique |
Here we present an adjustable algorithm to estimate the infection risk for different indoor environments, constrained
by published data of human aerosol emissions, SARS-CoV-2 viral loads, infective dose and other parameters. We evaluate typical indoor settings such as an office, a classroom, choir practice, and a reception/party. Our results suggest that aerosols from highly
infective subjects can effectively transmit COVID-19 in indoor environments. This “highly infective” category represents approximately 20% of the patients who tested positive for SARS-CoV-2. A particularly effective mitigation measure is the use of high-quality
masks, which can drastically reduce the indoor infection risk through aerosols. |
|
Li, L, Yu, et al |
Phys Ther |
Healthcare Response | Réponse des soins de santé |
This article reports a physical therapy service specially commissioned by the Health Commission of Sichuan Province
to manage COVID-19 during patients’ stay in the intensive care unit (ICU) at the Public Health Clinical Center of Chengdu in China. The respiratory and physical functions of some patients remained poor at ICU discharge, suggesting that long-term rehabilitation
may be required for these patients. Our experience in the management of patients with COVID-19 has revealed that physical therapist intervention is safe and appears to be associated with an improvement in respiratory and physical function in patients with
COVID-19 in the ICU. |
|
|
Li, M, Guo, et al |
Frontiers in Immunology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Here, we evaluated the subsets, phenotypic and functional characteristics of natural killer (NK) and T cells in patients
with COVID-19 and their associations with disease severity. The functional exhaustion and other subset alteration of NK and T cells may contribute to the progression and improve the prognosis of COVID-19. Surveillance of lymphocyte subsets may in the future
enable early screening for signs of critical illness and understanding the pathogenesis of this disease. |
|
|
Li, S, Xu, et al |
J Health Psychol |
Mental Health |
|
We examined the role of family support in influencing attitudes about social distancing and positive mental health
during the COVID-19 pandemic among 1547 Chinese people. These results suggest that strong support from family plays an important role in improving individuals' attitudes about social distancing and maintaining positive mental health during the epidemic. |
|
|
Li, Wei, Yang, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, by comparing the genomic sequences of SARS-CoV-2 and human, we identified five fully conserved elements in SARS-CoV-2
genome, which were termed as “human identical sequences (HIS)”. Our results revealed that unprecedented HIS elements of SARS-CoV-2 contribute to the cytokine storm and ARDS in COVID-19 patients. Thus, blocking HIS-involved activating processes or hyaluronan
synthesis directly by 4-MU may be effective strategies to alleviate COVID-19 progression. |
|
|
Li, Y, Wang, et al |
Risk Management and Healthcare Policy |
Healthcare Response | Réponse des soins de santé RCT |
In order to enable medical staff to learn how to don and doff PPE faster and more effectively, we compared two training
methods of PPE donning and doffing. Participants in this study were 48 health care workers randomly divided into two groups. Group A watched a 10-minute demonstration (demo) video four times, while Group B watched the same 10-minute demo video twice and then
watched a 10-minute live demo twice. The average score of Group B was higher than that Group A, with a mean (SD) of 94.92 (1.72) vs 86.63 (6.34), respectively (P< 0.001). |
|
|
Pharmacotherapy for Hospitalized Patients with COVID-19: Treatment Patterns
by Disease Severity |
Lin, KJ, Schneeweiss, et al |
Drugs |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The objectives of the study were to evaluate pharmacological treatment patterns by COVID-19 severity and identify the
determinants of prescribing for COVID-19. Among 2821 patients hospitalized for COVID-19, we found inpatient mortality increased by severity from 5% for level 1 to 23% for level 5. As compared to patients with severity level 1, those with severity level 5 were
3.53 times (95% confidence interval 2.73–4.57) more likely to receive a medication used to treat COVID-19. Careful consideration of disease severity and other determinants of COVID-19 drug use is necessary for appropriate conduct and interpretation of non-randomized
studies evaluating outcomes of COVID-19 treatments. |
|
De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2 |
Linsky, TW, Vergara, et al |
Science |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique Animal model | Modèle animal |
We developed a de novo protein design strategy to swiftly engineer decoys for neutralizing pathogens that exploit extracellular
host proteins to infect the cell. Our pipeline allowed the design, validation, and optimization of de novo hACE2 decoys to neutralize SARS-CoV-2. The best decoy, CTC-445.2, binds with low nanomolar affinity and high specificity to the RBD of the spike protein.
CTC-445.2d potently neutralizes SARS-CoV-2 infection of cells in vitro and a single intranasal prophylactic dose of decoy protected Syrian hamsters from a subsequent lethal SARS-CoV-2 challenge. |
|
33095246; Seropositive Prevalence of Antibodies Against SARS-CoV-2 in Wuhan,
China |
Liu, A, Li, et al |
JAMA network open |
Epidemiology| Épidémiologie Immunology | Immunologie |
This study found that the seropositive prevalence was 3.9% in a cohort of 35 040 individuals in Wuhan, China. Most
individuals tested positive for SARS-CoV-2 IgG antibodies only, indicating a prior infection. We further showed that the seropositive prevalence in the urban districts was higher than that in the suburban and rural areas. |
|
Liu, T, Jia, et al |
Frontiers in Microbiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Coronavirology| Coronavirologie |
We explored the features and evolutionary difference of viral gene expression in the SARS-CoV-2 infected cells from
the bronchoalveolar lavage fluids of patients with moderate and severe COVID-19 using both single cell and bulk tissue transcriptome data. We found SARS-CoV-2 sequences were detectable in 8 types of immune related cells, including macrophages, T cells, and
NK cells. These results implicated potential roles and predictive features of viral transcripts in the pathogenesis of COVID-19 moderate and severe patients. |
|
|
Generation of Chicken IgY against SARS-COV-2 Spike Protein and Epitope Mapping |
Lu, Y, Wang, et al |
Journal of Immunology Research |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study, we raised antibody against the spike (S) protein of SARS-CoV-2 in chickens and extracted IgY (called
IgY-S) from egg yolk. IgY-S exhibited high immunoreactivity against SARS-CoV-2 S, and by epitope mapping, we found five linear epitopes of IgY-S in SARS-CoV-2 S, two of which are cross-reactive with SARS-CoV S. |
|
Mac, Stephen, Barrett, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We conducted a population-based cohort study using public health data to describe COVID-19 associated age- and sex-specific
acute care use, length of stay (LOS), and mortality. During the observation period, 56,476 COVID-19 cases were reported (72% < 60 years, 52% female). The proportion of cases shifted from older populations (> 60 years) to younger populations (10-39 years) over
time. Overall, 10% of individuals were hospitalized, of those 22% were admitted to ICU, and 60% of those used IMV. All outcomes varied by age and decreased over time, overall and within age groups. |
|
|
Magallanes-Garza, G, Valdez-Alatorre, et al |
Int J Gynaecol Obstet |
Clinical data| Données cliniques |
On June, 21, 2020, a 33-year-old pregnant woman (27(4) gestational weeks) with SARS-CoV-2 infection presented to Hospital
San José Tec Salud, Monterrey, México, with respiratory distress and oxygen saturation below 90% (room oxygen). She had developed fever, asthenia, adynamia, myalgia, dry cough, anosmia, and diarrhea 7 days prior to admission. Her past medical history was significant
for smoking, which she had stopped at 4 gestational weeks. |
|
|
Mamo, Y, Asefa, et al |
International Journal of General Medicine |
Public Health response| Interventions de santé publique |
The aim of this study was to assess public perceptions toward quarantine for COVID-19 and associated factors among
adult residents of selected towns in Southwest Ethiopia, 2020. Only 52.3% of the respondents have a positive perception toward quarantine. Having training on COVID-19, educational status of secondary and above, being a merchant, knowledge of COVID-19 and knowledge
of quarantine were significantly associated with a positive perception toward quarantine. |
|
|
Manisty, Charlotte, Treibel, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
We present a detailed temporal analysis of circulating antibody in a cohort of hospital health care workers in a prospective
longitudinal multi-centre cohort study with high frequency serial sampling over 16-21 weeks during the first epidemic wave in London, UK. A total of 157/729 (21.5%) participants developed positive SARS-CoV-2 serology by one or other assay, of whom 31.0% were
asymptomatic and there were no deaths. Mild SARS CoV 2 infection was associated with heterogenous serological responses in Euroimmun anti-S1 and Roche anti-NP assays. Anti-S1 responses showed faster rates of clearance, more rapid transition from high to low
level production rate and greater reduction in production rate after this transition. |
|
|
Martin, A, Nateqi, et al |
Sci Rep |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Symptoma is a symptom-to-disease digital health assistant that can differentiate more than 20,000 diseases with an
accuracy of more than 90%. We tested the accuracy of Symptoma to identify COVID-19 using a set of diverse clinical cases combined with case reports of COVID-19. We showed that Symptoma can accurately distinguish COVID-19 in 96.32% of clinical cases. When
considering only COVID-19 symptoms and risk factors, Symptoma identified 100% of those infected when presented with only three signs. |
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|
COVID-19 and Tuberculosis Coinfection in a 51-Year-Old Taxi Driver in Mexico City |
Martínez Orozco, JA, Sánchez Tinajero, et al |
Am J Case Rep |
Clinical data| Données cliniques |
We report on a case of SARS-CoV-2/Mycobacterium tuberculosis (MBT) coinfection in a 51-year-old taxi driver from Mexico
City. The present report underscores the importance of using validated molecular diagnostic tests to identify coinfections in areas where there is a high prevalence of other causes of pneumonia. The patient was discharged from the hospital 10 days later. |
|
Mayuramart, O, Nimsamer, et al |
Exp Biol Med (Maywood) |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In this study, CRISPR-Cas12a-based detection was applied for detection of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), influenza A virus, and influenza B virus. The limit of detection for SARS-CoV-2 was 10 copies/reaction. Moreover, the assays yielded no cross-reactivity against other respiratory viruses. The results revealed that the detection of influenza
virus and SARS-CoV-2 by using RT-RPA and CRISPR-Cas12a technology reaches 96.23% sensitivity and 100% specificity for SARS-CoV-2 detection. |
|
|
The Health Of Us Adolescent Athletes During Covid-19 Related School Closures And Sport Cancellations |
McGuine, TA, Biese, et al |
J Athl Train |
Mental Health |
|
The objective of this study was to describe the health of adolescent athletes during COVID-19 related school closures
and sport cancellations. Mental health, physical activity and quality of life variables were compared between sex, grade, sports played and poverty level. Females reported a higher prevalence of moderate to severe anxiety symptoms. Physical activity was highest
for grade 9 and lowest for grade 11. The prevalence of depression symptoms was highest in team sport and lowest for individual sport participants. The total Pediatric Quality of Life score was worst for athletes from counties with the highest poverty levels. |
|
SARS-CoV-2 Assembly and Egress Pathway Revealed by
Correlative Multi-modal Multi-scale Cryo-imaging |
Mendonca, Luiza, Howe, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, we investigated SARS-CoV-2 replication in Vero cells under the near-native frozen-hydrated condition using a
unique correlative multi-modal, multi-scale cryo-imaging approach. Our results reveal at the whole cell level profound cytopathic effects of SARS-CoV-2 infection. Furthermore, cryoET of cell lamellae reveals how viral RNAs are transported from double-membrane
vesicles where they are synthesized to viral assembly sites; how viral spikes and RNPs assist in virus assembly and budding; and how fully assembled virus particles exit the cell, thus stablishing a model of SARS-CoV-2 genome replication, virus assembly and
egress pathways. |
|
Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier
failure |
Michalick, L, Weidenfeld, et al |
Eur Respir J |
Clinical data| Données cliniques |
This study reports a screening platform for endothelial barrier regulation, that can be utilised to i) identify pathologic
mediators and ii) screen for the therapeutic potential of barrier stabilising compounds in COVID-19. Citrate plasma was sampled as part of the prospective observational Pa-COVID-19 cohort study in 14 patients with moderate and 19 with severe COVID-19. Plasma
from COVID-19 patients induced a rapid (within 1–2 h) and sustained (>6 h) increase in endothelial permeability of HPMEC monolayers, which was more pronounced in plasma from patients with severe infection. |
|
Mondal, P, Natesh, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The current study was undertaken to evaluate the therapeutic potential of traditional medicinal plants against COVID-19.
The binding energies of several bioactives analyzed with target proteins were relatively comparable and even better than the standard drugs. The selected bioactives were found to have lower toxicity with a higher GI absorption rate and potent anti-inflammatory
and anti-viral activities against targets of COVID-19. |
|
|
Murray, G, Roche, et al |
Br J Dermatol |
Healthcare Response | Réponse des soins de santé |
An analysis of skin cancer referrals from the National Cancer Control Programme (NCCP) Ireland from January to June
in 2019 and 2020 showed that there has been a decrease in referrals since the introduction of the lockdown in March, April and May. Data from Google Trends demonstrated a decrease in internet search activity for both skin cancer and melanoma during Covid-19.
This could suggest that a reduction in online health and information seeking behaviour for skin cancer and melanoma is a result of patients’ interests shifting towards that of Covid-19, and thus be a possible factor that has contributed to the reduced skin
cancer referrals observed. |
|
|
N, CYY, Huang, et al |
Int J Environ Res Public Health |
Mental Health |
|
This study examined the psychosocial correlates of probable anxiety among Filipina domestic helpers (FDH) in Hong Kong
amid the COVID-19 pandemic. By purposive sampling, FDHs (n = 295) were recruited and invited to complete a cross-sectional survey. Multivariate regression results showed that the insufficiency of protective equipment (OR = 1.58, 95% CI: 1.18, 2.11), increased
workload (OR = 1.51, 95% CI: 1.02, 2.25), and worries about being fired if getting COVID-19 (OR = 1.32, 95% CI: 1.04, 1.68) were significantly associated with probable anxiety. Our findings shed light on the importance of addressing employment-related rights
and pandemic-specific worries through interventions among FDHs in Hong Kong during pandemic situations. |
|
|
Naik, PA, Yavuz, et al |
European Physical Journal Plus |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In the present paper, a fractional-order epidemic model with two different operators called the classical Caputo operator
and the Atangana–Baleanu–Caputo operator for the transmission of COVID-19 epidemic is proposed and analyzed. The reproduction number R is obtained for the prediction and persistence of the disease. The numerical solution of the proposed COVID-19 fractional-order
model under the Caputo operator is obtained by using generalized Adams–Bashforth–Moulton method, whereas for the Atangana–Baleanu–Caputo operator, we have used a new numerical scheme. Furthermore, numerical simulations of the model and their graphical presentations
are performed to visualize the effectiveness of our theoretical results and to monitor the effect of arbitrary-order derivative. |
|
|
Platelet Activating Immune Complexes Identified in
COVID-19 Associated Coagulopathy |
Nazy, Ishac, Jevtic, et al |
medRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
This COVID-19 associated coagulopathy (CAC) shares features with heparin-induced thrombocytopenia (HIT), including
mild thrombocytopenia and thrombosis. We thus tested 10 CAC patients for anti-PF4/heparin antibodies and functional platelet activation. HIT was excluded in all samples based on anti-PF4/heparin antibody and serotonin release assay results. Of note, 6 CAC
patients demonstrated platelet activation by the serotonin release assay that was inhibited by FcγRIIA receptor blockade, confirming an IgG-specific immune complex (IC)-mediated reaction. All 6 samples were positive for IgG-specific antibodies targeting the
receptor binding domain (RBD) or the spike protein of the SARS-CoV-2 virus. These samples were additionally characterized by significant endothelial activation, shown by increased von Willebrand factor antigen and activity. ADAMTS13 activity was not severely
reduced, and ADAMTS13 inhibitors were not present, ruling out thrombotic thrombocytopenic purpura. Our study thus identifies platelet-activating ICs as a mechanism that contributes to CAC thrombosis. |
|
Nsoesie, ElaineO, Sy, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this study, we use searches of COVID-19 symptoms, questions, and at-home remedies submitted to Google to model COVID-19
in South Africa, and assess how well the Google search data forecast short-term COVID-19 trends. Our findings suggest that information seeking trends on COVID-19 could guide models for anticipating COVID-19 trends and coordinating appropriate response measures. |
|
|
Padalabalanarayanan, S, Hanumanthu, et al |
JAMA network open |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
The aim of this study is to investigate whether state-imposed stay-at-home orders (SAHOs) and the proportion of African
American population in a state were associated with the state-level COVID-19 cases. This cross-sectional study used daily, state-level data on COVID-19 cases, tests, and fatalities from the COVID Tracking Project. Data from March 1 to May 4, 2020, for all
states (except Washington state) as well as the District of Columbia were used. The key exposure variables were state-level SAHO (1 if in place, 0 otherwise), and proportion of state population who are African American. The final sample included 3023 pooled
state- and day-level observations. There was a negative association of SAHOs with cumulative case rates (β = -1.166; 95% CI, -1.484 to -0.847; P < .001) and subsequent fatality rates (β = -0.204; 95% CI, -0.294 to -0.113; P < .001). These findings could help
inform policy makers to address the continued COVID-19 pandemic in the US. |
|
|
Park, MH, Kim, et al |
Medicina (Lithuania) |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Here, we report three patients that successfully recovered from COVID-19-induced ARDS after venovenous extracorporeal
membrane oxygenation (VV-ECMO) and implementation of an ultra-protective ventilation. This ventilation strategy involved maintaining a peak inspiratory pressure of ≤20 cmH2 O and a positive end-expiratory pressure (PEEP) of ≤10 cmH2 O, which are lower values
than have been previously reported. Thus, we suggest that this ultra-protective ventilation be considered during VV-ECMO as it minimizes the ventilator-induced lung injury. |
|
|
Pellegrini, CA, Webster, et al |
Obesity Science and Practice |
Mental Health |
|
This study examined how stress was associated with mental well-being and weight loss behaviors during the COVID-19
pandemic among adults enrolled in an internet-based weight loss program. Participants enrolled in a weight-loss program residing in Rhode Island or Massachusetts, USA, completed a brief survey on their mental health and current weight-loss behaviors during
the COVID-19 pandemic. Surveys were completed between 14 April 2020 and 21 April 2020, approximately one month after stay-at-home orders were mandated. Greater stress was associated with higher BMI (p = 0.04), higher education (p = 0.04), working more hours
(p = 0.003), and having school-age children at home (p = 0.002). Greater stress was also associated with higher levels of anxiety, worry, and concern regarding COVID-19 (p's < 0.001) and having less time to spend on weight-loss efforts (p < 0.001), after controlling
for BMI and education. Many individuals enrolled in a weight-loss program experienced more stress during COVID-19 compared to before the pandemic. |
|
|
Post-COVID-19 Epidemic: Allostatic Load among Medical and Nonmedical Workers in China |
Peng, M, Wang, et al |
Psychother Psychosom |
Mental Health |
|
During the reopening of society, medical and nonmedical workers were compared in terms of allostatic load. An online
study was performed; 3,590 Chinese subjects were analyzed. Socio-demographic variables, allostatic load, stress, abnormal illness behavior, global well-being, mental status, and social support were assessed. There was no difference in allostatic load in medical
workers compared to nonmedical workers (15.8 vs. 17.8%; p = 0.22). Multivariate conditional logistic regression revealed that anxiety (OR = 1.24; 95% CI 1.18-1.31; p < 0.01), depression (OR = 1.23; 95% CI 1.17-1.29; p < 0.01), somatization (OR = 1.20; 95%
CI 1.14-1.25; p < 0.01), hostility (OR = 1.24; 95% CI 1.18-1.30; p < 0.01), and abnormal illness behavior (OR = 1.49; 95% CI 1.34-1.66; p < 0.01) were positively associated with allostatic load. In the post-COVID-19 epidemic time, medical and nonmedical workers
had similar allostatic load. Psychological distress and abnormal illness behavior were risk factors for it, while social support could relieve it. |
|
Characteristics and outcomes of COVID-19-associated stroke: a UK multicentre case-control
study |
Perry, RJ, Smith, et al |
J Neurol Neurosurg Psychiatry |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study we set out to determine which characteristics and outcomes of stroke are associated with COVID19. This
case-control study included patients admitted with stroke to 13 hospitals in England and Scotland between 9th March and 5th July 2020. We collected data on 86 strokes (81 ischaemic strokes and 5 intracerebral haemorrhages)in patients with evidence of COVID-19
at the time of stroke onset (Cases). They were compared with 1384 strokes(1193 ischaemic strokes and 191 intracerebral haemorrhages) in patients admitted during the same time period who never had evidence of COVID19 (Controls). In addition the whole group
of stroke admissions, including another 37 in patients who appear to have developed COVID-19 after their stroke, were included in two logistic regression analyses examining which features were independently associated with COVID-19 status and with inpatient
mortality. Cases with ischaemic stroke were more likely than ischaemic controls to occur in Asians (18.8% vs 6.7%, p<0.0002), were more likely to involve multiple large vessel occlusions (17·9% vs 8.1%, p<0·03), were more severe (median NIHSS 8 vs 5, p<0·002),
were associated with higher D-dimer levels (p<0·01) and were associated withmore severe disability on discharge (median mRS 4 vs 3, p<0·0001) and inpatientdeath (19.8% vs9·6%, p<0·0001). |
|
Divergent: age, frailty, and atypical presentations of COVID-19 in hospitalized patients |
Poco, PCE, Aliberti, et al |
J Gerontol A Biol Sci Med Sci |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to investigate the association between age, frailty, and clinical characteristics of COVID-19 in hospitalized
middle-aged and older adults. Longitudinal observational study comprising 711 patients aged ≥50 years consecutively admitted to a university hospital dedicated to COVID-19 severe cases, between March and May 2020. We defined frailty using the Clinical Frailty
Scale (CFS=1-9; frail ≥5). Participants had a mean age of 66±11 years, and 43% were female. Overall, 25% were frail, and 37% died. The most common COVID-19 presentations were dyspnea (79%), cough (74%), and fever (62%), but patients aged ≥65 years were less
likely to have a co-occurrence of typical symptoms, both in the absence (OR=0.56; 95%CI=0.39-0.79) and in the presence of frailty (OR=0.52; 95%CI=0.34-0.81). In contrast, older age and frailty were associated with unspecific presentations. Atypical COVID-19
presentations are common in frail and older hospitalized patients. |
|
Prandi, L, Primiero, et al |
Applied Network Science |
Public Health response| Interventions de santé publique |
We studied the process of false information transmission by malicious agents, in the context of a disease pandemic
based on data for the COVID-19 emergency in Italy. We model communication of misinformation based on a negative trust relation, supported by findings in the literature that relate the endorsement of conspiracy theories with low trust level towards institutions.
We provide an agent-based simulation and consider the effects of a misinfodemic on policies related to lockdown strategies, isolation, protection and distancing measures, and overall negative impact on society during a pandemic. Our analysis shows that there
is a clear impact by misinfodemics in aggravating the results of a current pandemic. |
|
|
Quicke, Kendra, Gallichote, et al |
medRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
To assess the prevalence and incidence of SARS-CoV-2 among long term care facilities (LTCFs)workers, determine the
extent of asymptomatic SARS-CoV-2 infection, and provide information on the genomic epidemiology of the virus within these unique care settings, we collected nasopharyngeal swabs from workers for 8-11 weeks at six Colorado LTCFs, determined the presence and
level of viral RNA and infectious virus within these samples, and sequenced 54 nearly complete genomes. Our data reveal a strikingly high degree of asymptomatic/mildly symptomatic infection, a strong correlation between viral RNA and infectious virus, prolonged
infections and persistent RNA in a subset of individuals, and declining incidence over time. Our data suggest that asymptomatic SARS-CoV-2 infected individuals contribute to virus persistence and transmission within the workplace, due to high levels of virus.
Genetic epidemiology revealed that SARS-CoV-2 likely spreads between staff within an LTCF.C |
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Radhakrishnan, V, Ovett, et al |
Pediatr Hematol Oncol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Crowded outpatient clinics and common wards in many hospitals in low and middle-income countries predispose children,
caregivers, and health care workers to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report on the clinical features and outcomes of 15 children with cancer at our center who tested positive for SARS-CoV-2. Five out of 15
patients were symptomatic, and one patient required intensive care and respiratory support. All the patients in the study have recovered from the SARS-CoV-2 infection without any sequelae and have resumed their cancer treatment. |
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Children hospitalized for COVID-19 during first winter
of the pandemic in Buenos Aires, Argentina |
Raiden, Silvina, Cairoli, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to describe the characteristics of patients hospitalized for COVID-19 in a tertiary pediatric hospital
in the City of Buenos Aires, Argentina. Descriptive study, including all patients hospitalized for COVID-19 in a tertiary pediatric hospital, from 04/26/2020 to 10/31/2020. Demographic, clinical and epidemiological characteristics of the patients are described.
578 children and adolescents were hospitalized for COVID-19. The median age was 4.2 years and 83% had a history of close contact with a confirmed COVID-19 case. Regarding severity, 30.8% were asymptomatic, 60.4% mild, 7.4% moderate, and 1.4% severe. Among
those with symptoms, the most frequent was fever, followed by sore throat and cough. Conclusion: We reported 578 cases of children and adolescents hospitalized for COVID-19, most of them showed a mild or asymptomatic condition. |
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Racial and Ethnic Disparities in COVID-19 Outcomes: Social Determination of Health |
Raine, S, Liu, et al |
Int J Environ Res Public Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Cross-sectional analysis from COVID Boston University's Center for Antiracist Research COVID Racial Data Tracker was
performed to evaluate the racial and ethnic distribution of COVID-19 outcomes relative to representation in the United States. Representation quotients (RQs) were calculated to assess for disparity using state-level data from the American Community Survey
(ACS). We found that on a national level, Hispanic/Latinx, American Indian/Alaskan Native, Native Hawaiian/Pacific Islanders, and Black people had RQs > 1, indicating that these groups are over-represented in COVID-19 incidence. Dramatic racial and ethnic
variances in state-level incidence and mortality RQs were also observed. This study investigates pandemic disparities and examines some factors which inform the social determination of health. |
|
Rasmussen, Steen, Petersen, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Clinical
data| Données cliniques |
The objective was to develop a robust method for reliable estimation of the epidemic and the healthcare system load
in Denmark, both retrospectively and prospectively. A new pandemic simulation was developed, taking into account the size and the infection impact of the infectious incubating and asymptomatic infected individuals (dark numbers). The epidemic simulation is
based on a SEIRS (Susceptible - Exposed - Infected - Recovered - Susceptible) model, coupled to a simple healthcare model that also includes deaths outside hospital settings. The SEIRS model has separate assessments of asymptomatic and symptomatic cases with
different immunological memories. The main data used for parameter estimation in the models are hospital and ICU occupations, death data, serological data of antibody prevalence from the onset through August 2020 together with hospital data and clinical data
about the viral infection. Optimal model parameters are in part identified by Monte Carlo based Least Square Error methods while micro-outbreaks are modeled by noise and explored in Monte Carlo simulations. Estimates for the infected population sizes are obtained
by using a quasi steady state method. The age adjusted antibody prevalence in the general population in May 2020 was 1.37%, which yields a relative frequency of symptomatic and asymptomatic cases of 1 to 5.2. Due to the large asymptomatic population found,
the actual mortality rate to date is 0.4%. However, with no behavioral and policy restrictions the COVID-19 death toll would have more than doubled the national average yearly deaths within a year. The transmission rate Ro was 5.4 in the initial free epidemic
period, 0.4 in the lock-down period and 0.8 -1.0 in the successive re-opening periods through August 2020. The estimated infected population size July 15 to August 15 was 2,100 and 12,200 for October 1 - 20, 2020. The efficiency of the applied daily testing
strategy for both periods are estimated to be 40% of the PCR observable infected. |
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Rentsch, ChristopherT, DeVito, et al |
The Lancet Rheumatology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
Hydroxychloroquine has been shown to inhibit entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
into epithelial cells in vitro, but clinical studies found no evidence of reduced mortality when treating patients with COVID-19. We aimed to evaluate the effectiveness of hydroxychloroquine for prevention of COVID-19 mortality, as opposed to treatment for
the disease. |
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Riccio, MP, Borrelli, et al |
Int J Environ Res Public Health |
Mental Health |
|
This study assessed the psychological well-being of in primary ciliary dyskinesia (PCD) population during COVID-19
lockdown in Italy. 27 PCD patients and 27 healthy controls were recruited. To assess psychological well-being, psychological general well-being index and parenting stress index-short questionnaires were administered to participants ≥15 years-old and to mothers
of participants <15 years-old, respectively. The PCD exacerbations since outbreak onset and frequency of quarantine weekly chest physiotherapy were compared to the same period of 2019. 70% of PCD mothers and 90% of PCD patients did not show parental stress
levels or distress levels, respectively, and these groups showed no significant difference in stress compared to controls. The PCD pulmonary exacerbations occurred less frequently and weekly chest physiotherapy sessions significantly increased compared to
the same period during 2019 (p < 0.05). PCD population showed psychological well-being. |
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Rouchka, EC, Chariker, et al |
PLoS One |
Coronavirology| Coronavirologie |
We have performed a comparative analysis of the sequences, in order to detect common mutations within the population.
Analysis of variants occurring within the assembled genomes yields 417 variants occurring in at least 1% of the completed genomes, including 229 within the 5' untranslated region (UTR), 152 within the 3'UTR, 2 within intergenic regions and 34 within coding
sequences. |
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Ruan, Y, Hu, et al |
Andrology |
Clinical data| Données cliniques |
The objective was to evaluate urogenital involvement in recovered COVID-19 patients. Men aged between 20 years and
50 years who were diagnosed with SARS-CoV-2 infection and recovered when the study was conducted were enrolled in our study. Demographic, clinical characteristics and history of hospitalization were collected and analyzed. Urine, expressed prostatic secretions
(EPS) and semen samples were collected for SARS-CoV-2 RNA detection. Semen quality and hormonal profiles were analyzed. Among 74 male recovered COVID-19 patients, 11 (14.9%) were asymptomatic, classified into mild type, and 31 (41.9%) were classified into
moderate type. The remaining patients (32/74, 43.2%) had severe pneumonia. No critically ill recovered COVID-19 patient was recruited in our cohort. Direct urogenital involvement was not found in the recovered COVID-19 male patients. SARS-CoV-2 RNA was undetectable
in the urogenital secretions, and semen quality declined slightly while hormonal profiles remained normal. Moreover, patients with a long time (≥ 90 days) since recovery had lower total sperm count. |
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Sarabia-Cobo, C, Pérez, et al |
J Adv Nurs |
Healthcare Response | Réponse des soins de santé |
The objective was to explore the emotional impact and experiences of geriatric nurses working in nursing homes and
caring for patients with COVID-19. This is a qualitative study with phenomenological method and data were gathered through in-dept interview. The experiences and expectations that nurses are facing during their care duties were explored via video conference,
using a semi-structured interview guide. 24 interviews were conducted with nurses from four countries (Spain, Italy, Peru and Mexico) during April 2020. Three main categories were extracted: fear of the pandemic situation, the sense of duty and professional
commitment, and emotional exhaustion. Regardless of the country and situation, in the face of the pandemic, dramatic situations have been experienced in nursing homes worldwide, with nursing staff feeling exhausted and overwhelmed, and reflection is urged
on a global level to consider the most appropriate model of care in nursing homes. |
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Sardar, R, Satish, et al |
Frontiers in Genetics |
Coronavirology| Coronavirologie |
We have used a network biology approach to elucidate the crucial factors involved in host responses involving host–microRNA
(miRNA) interactions with host and virus genes using recently published experimentally verified protein–protein interaction data. We were able to identify 311 host genes to be potentially targetable by 2,197 human miRNAs. These miRNAs are known to be involved
in various biological processes, such as T-cell differentiation and activation, virus replication, and immune system. Among these, the anti-viral activity of 38 miRNAs to target 148 host genes is experimentally validated. Six anti-viral miRNAs, namely, hsa-miR-1-3p,
hsa-miR-17-5p, hsa-miR-199a-3p, hsa-miR-429, hsa-miR-15a-5p, and hsa-miR-20a-5p, are previously reported to be anti-viral in respiratory diseases and were found to be downregulated. The interaction network of the 2,197 human miRNAs and interacting transcription
factors (TFs) enabled the identification of 51 miRNAs to interact with 77 TFs inducing activation or repression and affecting gene expression of linked genes. Further, from the gene regulatory network analysis, the top five hub genes HMOX1, DNMT1, PLAT, GDF1,
and ITGB1 are found to be involved in interferon (IFN)-α2b induction, epigenetic modification, and modulation of anti-viral activity. The comparative miRNAs target identification analysis in other respiratory viruses revealed the presence of 98 unique host
miRNAs targeting SARS-CoV-2 genome. Our findings identify prioritized key regulatory interactions that include miRNAs and TFs that provide opportunities for the identification of novel drug targets and development of anti-viral drugs. |
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Scelfo, C, Fontana, et al |
Therapeutics and Clinical Risk Management |
Clinical data| Données cliniques |
We report two cases of respiratory insufficiency due to COVID-19 pneumonia that occurred in adults without a history
of respiratory diseases. Although these patients improved and were discharged from the acute ward, during the hospitalization they both progressed with a subsequent clinical and radiological worsening, pointing out one of the main concerns for these patients
at discharge: the possibility of developing persistent lung abnormalities also in healthy people not having other risk factors. In conclusion, these cases represent two examples of early lung fibrosis in patients with COVID-19 pneumonia with different severity
disease evolution and highlight the need for long-term follow-up strategies. |
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Schetelig, Johannes, Baldauf, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
DKMS is a non-profit donor center for stem cell donation and reaches out to registered volunteers between 18 and 61
years of age. To identify risk factors for severe COVID-19 courses in this population we performed a cross-sectional study. Self-reported data on oro- or nasopharyngeal swabs, risk factors, symptoms and treatment were collected with a health questionnaire
and linked to existing genetic data. We fitted multivariable logistic regression models for the risk of contracting SARS-CoV-2, risk of severe respiratory infection and risk of hospitalization. Findings. Of 4,440,895 contacted volunteers 924,660 (20.8%) participated
in the study. Among 157,544 participants tested, 7,948 reported SARS-CoV-2 detection. Of those, 947 participants (11.9%) reported an asymptomatic course, 5,014 (63.1%) mild/moderate respiratory infections, and 1,987 (25%) severe respiratory tract infections.
In total, 286 participants (3.6%) were hospitalized for respiratory tract infections. The risk of hospitalization in comparison to a 20-year old person of normal weight was 2.1-fold higher (95%-CI, 1.2-3.69, p=0.01) for a person of same age with a BMI between
35-40 kg/m2, it was 5.33-fold higher (95%-CI, 2.92-9.70, p<0.001) for a 55-year old person with normal weight and 11.2-fold higher (95%-CI, 10.1-14.6, p<0.001) for a 55-year old person with a BMI between 35-40 kg/m2. Blood group A was associated with a 1.15-fold
higher risk for contracting SARS-CoV-2 (95%-CI 1.08-1.22, p<0.001) than blood group O but did not impact COVID-19 severity. In this relatively healthy population, the risk for hospitalizations due to SARS-CoV-2 infections was moderate. Age and BMI were major
risk factors. |
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An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike |
Schoof, M, Faust, et al |
Science |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The SARS-CoV-2 virus enters host cells via an interaction between its Spike protein and the host cell receptor angiotensin
converting enzyme 2 (ACE2). By screening a yeast surface-displayed library of synthetic nanobody sequences, we developed nanobodies that disrupt the interaction between Spike and ACE2. Cryogenic electron microscopy (cryo-EM) revealed that one nanobody, Nb6,
binds Spike in a fully inactive conformation with its receptor binding domains (RBDs) locked into their inaccessible down-state, incapable of binding ACE2. Affinity maturation and structure-guided design of multivalency yielded a trivalent nanobody, mNb6-tri,
with femtomolar affinity for Spike and picomolar neutralization of SARS-CoV-2 infection. mNb6-tri retains function after aerosolization, lyophilization, and heat treatment, which enables aerosol-mediated delivery of this potent neutralizer directly to the
airway epithelia. |
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Schulberg, SP, Jaikaran, et al |
Surg Innov |
Healthcare Response | Réponse des soins de santé |
At our New York City hospital, we developed the ancillary central catheter emergency support service (ACCESS), a team
for dedicated central access staffed by surgical residents to assist in the care of critical COVID-19 patients. We conducted a retrospective review of all patients for whom the team was activated. Furthermore, we distributed a survey to the critical care department
to assess their perceived time saved per patient. The ACCESS team placed 104 invasive catheters over 10 days with a low complication rate of .96%. All critical care providers surveyed found the service useful and felt it saved at least 30 minutes of procedural
time per patient, as patient to critical care provider ratios were increased from 12 patients to one provider to 44 patients to one provider. |
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COVID-19 and LGBTQ Emerging Adults: Risk in the Face of Social Distancing |
Scroggs, B, Love, et al |
Emerging Adulthood |
Mental Health |
|
The coronavirus pandemic that began in December 2019 (COVID-19) quickly spread globally with an increased transmission
in the United States beginning in March 2020. Social distancing guidelines were instituted across the country, limiting contact individuals could have with others. This compared the mental health of lesbian, gay, bisexual, transgender, and queer (LGBTQ) emerging
adults who completed the survey before (n = 1,190) many social distancing guidelines went into effect with those who completed the survey after (n = 705). Participants who participated in the survey after social distancing guidelines were initiated reported
lower levels of hope for the future, higher levels of alcohol use, a lower sense of connection to and pride regarding the LGBTQ community, and a lower sense of minority stress. Results indicate a detrimental response to social distancing in the days immediately
following the onset of such guidelines as confusion reigned and expectations changed day to day. © 2020 Society for the Study of Emerging Adulthood and SAGE Publishing. |
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Seadawy, Mohamed |
Research Square prepub |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The current pandemic of the coronavirus disease-2019 (COVID-19) has badly affected our life during the year 2020. SARS-CoV-2
is the primary causative agent of the newly emerged pandemic. Natural flavonoids, Terpenoid and Thymoquinone are tested against different viral and host-cell protein targets. These natural compounds have a good history in treating Hepatitis C Virus (HCV) and
Human Immunodeficiency Virus (HIV). Molecular docking combined with cytotoxicity and plaque reduction assay is used to test the natural compounds against different viral (Spike, RdRp, and Mpro) and host-cell (TMPRSS II, keap 1, and ACE2) targets. The results
demonstrate the binding possibility of the natural compounds (Thymol, Carvacrol, Hesperidine, and Thymoquinone) to the viral main protease (Mpro). Some of these natural compounds were approved to start clinical trail from Egypt Center for Research and Regenerative
Medicine ECRRM IRB (Certificate No.IRB00012517) |
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Serrano-Ripoll, Maria, Ricci Cabello, et al |
medRxiv |
Mental Health |
|
Clinical trial application. Aim to evaluate the impact of a psychoeducational, mobile health intervention based on
cognitive behavioural therapy and mindfulness-based approaches on the mental health of healthcare workers at the frontline against COVID-19 in Spain. Will carry out a two−week, individually randomised, parallel group, controlled trial. Participants will be
individually randomised to receive the PsyCovidApp intervention or control App intervention. Healthcare workers having attended COVID-19 patients will be randomized to receive the PsyCovidApp intervention (intervention group) or a control App intervention
(control group). A total of 440 healthcare workers will be necessary to assure statistical power. Measures will be collected telephonically by a team of psychologists at baseline and immediately after the two weeks intervention period. Measures will include
stress, depression and anxiety (DASS−21 questionnaire − primary endpoint), insomnia (ISI), burnout (MBI−HSS), post-traumatic stress disorder (DTS), and self-efficacy (GSE). The findings from this study will help health services and organizations to make informed
decisions in relation to the development and implementation of mobile health interventions, allowing them pondering not only their attractive implementability features, but also empirical data about its benefits. |
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Impact of socio-economic status in patients hospitalised for COVID-19 in the Greater
Paris area |
Sesé, L, Nguyen, et al |
Eur Respir J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Evaluated the affects of socioeconomic status (SES) on initial severity of COVID-19 in France. Compared patient characteristics
between two districts (Seine-Saint-Denis (SSD), the poorest district of Greater Paris; Hauts-de-Seine (HDS), a rich district of Greater Paris) and determine whether precarity is a risk factor for severe COVID-19. The study population included 112 patients
(58.6% men, age: 66.7±16.3 years old, 11.0% Africans or Afro-Caribbeans, and 7.7% current smokers). Body mass index was 27.1±6.23, 30.0% patients had diabetes and 52.7% arterial hypertension. Regarding SES, 33.0% patients had an income below the poverty line,
and the mean deprivation index was 38.2±24.4. The proportion of patients with at least one infected home co-resident was 12%. COVID-19 was severe in most cases (59.8%). The distribution of initial severity was similar in both districts, although SSD patients
were about 10 years younger than HDS patients (61.8±14.0 versus 71.0±17.1 years). 17% were transferred in ICU and 3% died at hospital. No predictive factors of initial severity were found in the overall population. In the sub-group of patients under 70 years
of age, the predictive factors of severity were age, high EPICES score, being retired, and an absence of private insurance coverage. |
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Sharma, A, Rani, et al |
International Journal of Biomedical Imaging |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Created efficient deep learning models, trained with chest X-ray images, for rapid screening of COVID-19 patients.
The combination of two best-performing models (each trained on 286 images, rotated through 120° or 140° angle) displayed the highest prediction accuracy for normal, COVID-19, non-COVID-19, pneumonia, and tuberculosis images. AI-based classification models
trained through the transfer learning approach can efficiently classify the chest X-ray images representing studied diseases. Our method is more efficient than previously published methods. It is one step ahead towards the implementation of AI-based methods
for classification problems in biomedical imaging related to COVID-19. |
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Lysine 164 is critical for SARS-CoV-2 Nsp1 inhibition of host gene expression |
Shen, Z, Zhang, et al |
J Gen Virol |
Coronavirology| Coronavirologie |
Given that coronavirus nonstructural protein 1 (nsp1) is a good target for attenuated vaccines, it is of great significance
to explore the detailed characteristics of SARS-CoV-2 nsp1. Here, we first confirmed that SARS-CoV-2 nsp1 had a conserved function similar to that of SARS-CoV nsp1 in inhibiting host-protein synthesis and showed greater inhibition efficiency, as revealed by
ribopuromycylation and Renilla luciferase (Rluc) reporter assays. Specifically, bioinformatics and biochemical experiments showed that by interacting with 40S ribosomal subunit, the lysine located at amino acid 164 (K164) was the key residue that enabled SARS-CoV-2
nsp1 to suppress host gene expression. Furthermore, as an inhibitor of host-protein expression, SARS-CoV-2 nsp1 contributed to cell-cycle arrest in G0/G1 phase, which might provide a favourable environment for virus production. Taken together, this research
uncovered the detailed mechanism by which SARS-CoV-2 nsp1 K164 inhibited host gene expression, laying the foundation for the development of attenuated vaccines based on nsp1 modification. |
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Sieling, Peter, Zakin, et al |
medRxiv |
Vaccine Research| Recherche sur les vaccins Animal model | Modèle animal |
Developed a bivalent, human adenovirus serotype 5 (hAd5) SARS-CoV-2 S-Fusion + N-ETSD vaccine that is currently in
clinical testing. Here we report that the hAd5 S-Fusion + N-ETSD vaccine is recognized by anti-sera and T cells from previously SARS-CoV-2 infected patients, and that the presence of N is vital for T-cell recall. The findings presented herein: i. demonstrate
specific recognition of hAd5 S-Fusion + N-ETSD infected cells by plasma antibodies from previously SARS-CoV-2 infected patients, but not antibodies from virus-naive subjects; ii. show enhanced binding of plasma SARS-CoV-2 antibodies from previously infected
patients to monocyte-derived dendritic cells (MoDCs) expressing the hAd5 S-Fusion + N-ETSD vaccine as compared to hAd5 S-Fusion alone; iii. reveal N-ETSD localizes to vesicles associated with MHC class II antigen presentation, including endosomes, lysosomes,
and autophagosomes in MoDCs; iv. demonstrate endosome/lysosome-targeted N-ETSD elicits higher interferon-gamma T-cell responses than cytoplasm-localized N; and v. N-ETSD alone or in the hAd5 S-Fusion + N-ETSD construct induces both CD4+ and CD8+ T cell memory
recall. This recognition of hAd5 S-Fusion + N-ETSD vaccine antigens by T cells from previously SARS-CoV-2 infected patients, together with the ability of this vaccine candidate to elicit de novo immune responses in naive mice suggests that it re-capitulates
the natural immune response to SARS-CoV-2 to activate both B and T cells towards viral neutralization and recognition of infected cells, critical for prevention of COVID-19 disease. |
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Sigorski, D, Sobczuk, et al |
ESMO Open |
Mental Health |
|
Assessed the relationship between the level of anxiety caused by a neoplasm and the threat of coronavirus infection
among patients with cancer actively treated with systemic therapy during the COVID-19 pandemic. Enrolled 306 actively treated patients with cancer and collected their clinical data. The fear/anxiety of SARS-CoV-2 were rated in Fear of COVID-19 Scale (SRA-FCV-19S)
and Numerical Anxiety Scale (SRA-NAS). The fear and anxiety associated with cancer (CRA) were rated with the NAS (CRA-NAS). The mean level of SRA-FCV-19S was 18.5±7.44, which was correlated with the SRA-NAS (r=0.741, p65 years (6.73±2.96 vs 5.66±3.24; p=0.007).
The need for more attentive psychological care should be provided especially to female patients, patients with breast cancer, those under 65 years of age and treated with curative intention, as these factors are associated with a higher level of anxiety. |
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Sims, MD, Maine, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Immunology | Immunologie |
Presence of anti-SARS-CoV-2 IgG in blood and online assessment of demographic, and clinical was collected from 20,614
participants out of ~43,000 total employees at Beaumont Health, Michigan. A total of 1,818 (8.8%) participants were seropositive, 44% reported that they were asymptomatic during collection. Healthcare roles such as phlebotomy, respiratory therapy, and nursing/nursing
support exhibited significantly higher seropositivity. Among participants reporting direct exposure to a COVID-19 positive individual, those wearing an N95/PAPR mask had a significantly lower seropositivity rate (10.2%) compared to surgical/other masks (13.1%)
or no mask (17.5%). |
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Sinawi, HA, Al Balushi, et al |
Psychol Health Med |
Mental Health |
|
This was a web-based, cross-sectional study conducted using governmental and private institutional e-mail systems and
social media platforms. Anxiety and depression were assessed using both the Generalized Anxiety Disorder-7 Scale and the Patient Health Questionnaire-9. Logistic regression analysis was used to assess the independent predictors. There were a total of 1538
participants in this study (75% female). The prevalence of psychological distress was 30%. Being female, having financial instability, being treated for mental illness and self-medication for coping with stress were independent predictors of psychological
distress among the study sample . The results from this study will help public health officials in Oman to plan for and mitigate psychological repercussions of the current and future pandemics. |
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Soares, RubenRG, Akhtar, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Aiming at developing cost-effective viral load detection systems for point-of-care COVID-19 diagnostics in resource-limited
and resource-rich settings alike, we report the development of an integrated modular centrifugal microfluidic platform to perform loop-mediated isothermal amplification (LAMP) of viral RNA directly from heat-inactivated nasopharyngeal swab samples. The platform
provided results within 1 hour from sample collection and a detection limit between 100 and 1000 RNA copies in 10 μL reaction volume with Ct values below 26,
∼94% sensitivity and 100% specificity. |
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Soh, Wai Tuck, Liu, et al |
bioRxiv |
Coronavirology| Coronavirologie Immunology | Immunologie |
Angiotensin-converting enzyme 2 (ACE2) is the primary host cell receptor that interacts with the receptor-binding domain
(RBD) of the SARS-CoV-2 spike protein. In order to identify the additional receptors for the spike protein, we screened a receptor for the SARS-CoV-2 spike protein from the lung cDNA library. We cloned L-SIGN as a specific receptor for the N-terminal domain
(NTD) of the SARS-CoV-2 spike protein. The RBD of the spike protein did not bind to L-SIGN. L-SIGN and DC-SIGN induced membrane fusion by associating with the SARS-CoV-2 spike protein. Serum antibodies from infected patients and a patient-derived monoclonal
antibody against NTD inhibited SARS-CoV-2 infection of L-SIGN or DC-SIGN expressing cells. Our results highlight the important role of NTD in SARS-CoV-2 dissemination through L-SIGN and DC-SIGN and the significance of having anti-NTD neutralizing antibodies
in antibody-based therapeutics. |
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Pattern of COVID-19 in Sichuan province, China: A descriptive epidemiological
analysis |
Song, H, Cao, et al |
PLoS One |
Epidemiology| Épidémiologie |
Epidemiological information of 487 COVID-19 cases were collected from the official websites of 21 districts (including
18 cities, 3 autonomous prefecture) health commissions within Sichuan between 21st of January 2020 to 17th of April 2020. The number of single-day confirmed COVID-19 cases reach a peak on January 29 (33 cases), and then decreased. Chengdu (121 cases), Dazhou
(39 cases) Nanchong (37 cases) and Ganzi Tibetan Autonomous Prefecture (78 cases) contributed 275 cases (56.5% of the total cases) of Sichuan province. The history of living in or visiting Hubei, close contact, imported and unknown were 170 cases (34.9%),
136 cases (27.9%), 21 cases (4.3%) and 160 cases (32.9%) respectively. The interval from the onset of initial symptoms to laboratory diagnosis was 4.0 days in local cases, while that of imported cases was 4.5 days. |
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Wastewater Analysis of SARS-CoV-2 as a Predictive
Metric of Positivity Rate for a Major Metropolis |
Stadler, LaurenB, Ensor, et al |
medRxiv |
Epidemiology| Épidémiologie Surveillance |
Wastewater monitoring for SARS-CoV-2 has been suggested as an epidemiological indicator of community infection dynamics
and disease prevalence. We report wastewater viral RNA levels of SARS-CoV-2 in a major metropolis serving over 3.6 million people geographically spread over 39 distinct sampling sites. Viral RNA levels were followed weekly for 22 weeks, both before, during,
and after a major surge in cases, and simultaneously by two independent laboratories. We found SARS-CoV-2 RNA wastewater levels were a strong predictive indicator of trends in the nasal positivity rate two-weeks in advance. Furthermore, wastewater viral RNA
loads demonstrated robust tracking of positivity rate for populations served by individual treatment plants, findings which were used in real-time to make public health interventions, including deployment of testing and education strike teams. |
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Tabacof, Laura, Tosto-Mancuso, et al |
medRxiv |
Long-Term Sequelae |
|
This was a retrospective cross-sectional observational study. The aim of this research was to characterize post-acute
COVID-19 syndrome (PACS). Study survey demographic and clinical data were collected using REDCap from patients recovering from COVID-19 infection in Mount Sinai Hospital. 84 individuals with PACS were included. Symptoms persisted at mean (range) 151 (54 to
255) days. The most prevalent persistent symptoms were fatigue (92%), loss of concentration/memory (74%), weakness (68%), headache (65%) and dizziness (64%). Most participants reported increased levels of disability associated with breathlessness, increased
fatigue and reduced quality of life. |
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Tam, S, Wu, et al |
JAMA Otolaryngol Head Neck Surg |
Healthcare Response | Réponse des soins de santé |
After Henry Ford Health System clinics closed on March 17, 2020, the need to continue care necessitated a rapid adaptation
of telemedicine. This presented an opportunity for widespread telemedicine use within the multidisciplinary head and neck oncology team. The purpose of this article is to describe the associations between patient demographic characteristics and socioeconomic
disparities and the engagement in telemedicine during the pandemic. |
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Tesoriero, JamesM, Swain, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Surveillance |
NYS HIV surveillance, COVID-19 laboratory confirmed diagnoses, and hospitalization databases were matched and COVID-19
diagnoses, hospitalization, and in-hospital death rates comparing Persons Living with diagnosed HIV (PLWDH) to non-PLWDH were computed. PLWDH were more frequently diagnosed with COVID-19 than non-PLWDH. Per-population COVID-19 hospitalization was higher among
PLWDH. PLWDH experienced poorer COVID-related outcomes relative to non-PLWDH, with 1-in-522 PLWDH dying with COVID-19, seemingly driven by higher rates of severe disease requiring hospitalization. |
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Thomson, EmmaC, Rosen, et al |
bioRxiv |
Coronavirology| Coronavirologie Immunology | Immunologie |
Herein we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is the most divergent
region of S, and provide epidemiological, clinical, and molecular characterization of a prevalent RBM variant, N439K. We demonstrate that N439K S protein has enhanced binding affinity to the hACE2 receptor, and that N439K virus has similar clinical outcomes
and in vitro replication fitness as compared to wild-type. We observed that the N439K mutation resulted in immune escape from a panel of neutralizing monoclonal antibodies, including one in clinical trials, as well as from polyclonal sera from a sizeable fraction
of persons recovered from infection. Immune evasion mutations that maintain virulence and fitness such as N439K can emerge within SARS-CoV-2 S, highlighting the need for ongoing molecular surveillance to guide development and usage of vaccines and therapeutics. |
|
|
Chest CT Findings after 4 Months from the Onset of COVID-19 Pneumonia: A Case
Series |
Urciuoli, L, Guerriero, et al |
Diagnostics (Basel) |
Clinical data| Données cliniques |
Although the reference standard for SARS-CoV-2 diagnosis is real-time reverse transcription polymerase chain reaction
(RT-PCR), computed tomography (CT) is recommended for both initial evaluation and follow-up. There is a growing body of published evidence about CT evolution during the course of COVID-19 pneumonia. Here, we report six confirmed cases of COVID-19 patients
who underwent unenhanced chest CT on admission and after 4 months from the onset of symptoms. Chest-CT at first admission showed the typical CT features of COVID-19. Interestingly, the follow-up CT revealed the persistence of lung abnormalities in five cases
even if all the patients were completely asymptomatic. |
|
Variation in COVID-19 Data Reporting Across India: 6 Months into the Pandemic |
Vasudevan, V, Gnanasekaran, et al |
Journal of the Indian Institute of Science |
Surveillance |
In this communication, we assess the quality of COVID-19 data reporting done by the state and union territory governments
in India between July 12 and July 25, 2020. We conclude that 6 months into the pandemic, the quality of COVID-19 data reporting across India continues to be highly disparate, which could hinder public health efforts. |
|
Venter, C, Bezuidenhout, et al |
Int J Mol Sci |
Clinical data| Données cliniques Immunology | Immunologie |
Progressive respiratory failure is seen as a major cause of death in severe acute respiratory syndrome coronavirus
2 (SARS-Cov-2)-induced infection. Relatively little is known about the associated morphologic and molecular changes in the circulation of these patients. In particular, platelet and erythrocyte pathology might result in severe vascular issues, and the manifestations
may include thrombotic complications. These thrombotic pathologies may be both extrapulmonary and intrapulmonary and may be central to respiratory failure. Previously, we reported the presence of amyloid microclots in the circulation of patients with coronavirus
disease 2019 (COVID-19). Here, we investigate the presence of related circulating biomarkers, including C-reactive protein (CRP), serum ferritin, and P-selectin. These biomarkers are well-known to interact with, and cause pathology to, platelets and erythrocytes.
We also study the structure of platelets and erythrocytes using fluorescence microscopy (using the markers PAC-1 and CD62PE) and scanning electron microscopy. Thromboelastography and viscometry were also used to study coagulation parameters and plasma viscosity.
We conclude that structural pathologies found in platelets and erythrocytes, together with spontaneously formed amyloid microclots, may be central to vascular changes observed during COVID-19 progression, including thrombotic microangiopathy, diffuse intravascular
coagulation, and large-vessel thrombosis, as well as ground-glass opacities in the lungs. Consequently, this clinical snapshot of COVID-19 strongly suggests that it is also a true vascular disease and considering it as such should form an essential part of
a clinical treatment regime. |
|
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Perceptions and experiences of healthcare workers during the COVID-19 pandemic
in the UK |
Vindrola-Padros, C, Andrews, et al |
BMJ Open |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to explore the perceptions and experiences of healthcare workers (HCWs) in relation to COVID-19
and care delivery models implemented to deal with the pandemic in the UK. Staff working in the UK during the COVID-19 pandemic advocated clear and consistent guidelines, streamlined testing of HCWs, administration of PPE and acknowledgement of the effects
of PPE on routine practice. |
|
Wakashima, K, Asai, et al |
PLoS One |
Public Health response| Interventions de santé publique |
The aim of the present study was to verify the reliability and validity of the Japanese version of the Fear of COVID-19
Scale (FCV-19S) and to ascertain FCV-19S effects on assessment of Japanese people's coping behavior. These results suggest that the Japanese FCV-19S psychometric scale has equal reliability and validity to those of the original FCV-19S. |
|
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Wang, D, Hu, et al |
|
Coronavirology| Coronavirologie |
This report briefly introduces SARS-CoV-2's structure, basic characterization and replication process. |
|
|
Wang, F, Cao, et al |
Int J Epidemiol |
Epidemiology| Épidémiologie |
We report the characteristics of patients with severe or critical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection in Wuhan city, China, and the risk factors related to infection severity and death. Advanced age, male sex and a history of chronic disease were associated with COVID-19 critical illness and death. |
|
|
Ward, BrianJ, Gobeil, et al |
medRxiv |
Vaccine Research| Recherche sur les vaccins RCT |
The SARS-CoV-2 spike protein produced by transient expression in Nicotiana benthamiana formed Virus-Like-Particles
(CoVLP). Phase 1 study intended to assess the safety, tolerability, and immunogenicity of CoVLP at three dose levels (3.75 microgram, 7.5 microgram, and 15 microgram) unadjuvanted or adjuvanted with either CpG 1018 or AS03 in 180 SARS-CoV-2 seronegative healthy
adults 18 to 55 years of age. The primary endpoints were the safety and tolerability of the vaccine. Secondary endpoints were anti-spike antibody responses by ELISA and neutralizing antibodies measured by live virus plaque reduction neutralization test (PRNT)
assay at Days 0, 21 and 42. CoVLP administered with either CpG1018 or AS03 has a safety profile similar to other candidate vaccines for SARS-CoV-2. The antibody titers achieved were either similar to (CoVLP+CpG1018) or at least 10-times higher (CoVLP+AS03)
than those seen in convalescent plasma. |
|
|
Characteristics of three different chemiluminescence
assays for testing for SARS-CoV-2 antibodies |
Weber, Myriam, Risch, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
A chemiluminescent microparticle immunoassay (CMIA; Abbott Diagnostics, USA), a luminescence immunoassay (LIA; Diasorin,
Italy), and an electrochemiluminescence immunoassay (ECLIA; Roche Diagnostics, Switzerland) test for SARS CoV 2 antibodies were investigated.Although the diagnostic accuracy of the three investigated assays is comparable, their performance in low prevalence
settings is different. |
|
Weisberg, SP, Connors, et al |
Nat Immunol |
Clinical data| Données cliniques Immunology | Immunologie |
We show distinct antibody responses in children and adults after SARS-CoV-2 infection. Children are largely spared
from respiratory illness but can develop a life-threatening multisystem inflammatory syndrome (MIS-C). Children with and without MIS-C had reduced neutralizing activity as compared to both adult COVID-19 cohorts, indicating a reduced protective serological
response. |
|
|
Wolka, E, Zema, et al |
Risk Management and Healthcare Policy |
Public Health response| Interventions de santé publique |
The aim of this study was to explore the level of awareness and prevention methods of COVID-19 among residents in Wolaita
Zone, Southern Ethiopia. A total of 22 in-depth interviews were done. The findings revealed that 95.5% of the participants had heard about the disease COVID-19 and realized common modes of transmission. Some participants linked the disease with resentment
of God on people or anger of God towards human kind. Importance of consuming hot drinks, ginger or garlic to prevent the disease was reported by participants. Negative attitude towards quarantine and isolation centers and stigmatizing people with a cough were
documented in this assessment. Stigma and fear of isolation centers may prevent people from reporting the symptom of the disease and this can create favorable ground for the transmission. Challenges like problem of consistent availability of water supply,
affordability of materials used to keep hygiene by rural poor, and keeping physical distancing in different public gathering places were reported. |
|
|
Woodworth, KR, Olsen, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Surveillance |
Through the Surveillance for Emerging Threats to Mothers and Babies Network (SET-NET), 16 jurisdictions collected supplementary
information on pregnancy and infant outcomes among 5,252 women with laboratory-confirmed SARS-CoV-2 infection reported during March 29-October 14, 2020. Among 3,912 live births with known gestational age, 12.9% were preterm (<37 weeks), higher than the reported
10.2% among the general U.S. population in 2019 (4). Among 610 infants (21.3%) with reported SARS-CoV-2 test results, perinatal infection was infrequent (2.6%) and occurred primarily among infants whose mother had SARS-CoV-2 infection identified within 1 week
of delivery. Because the majority of pregnant women with COVID-19 reported thus far experienced infection in the third trimester, ongoing surveillance is needed to assess effects of infections in early pregnancy, as well the longer-term outcomes of exposed
infants. |
|
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Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2 |
Xiang, Y, Nambulli, et al |
Science |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique Immunology | Immunologie |
We used camelid immunization and proteomics to identify a large repertoire of highly potent neutralizing nanobodies
(Nbs) to the SARS-CoV-2 spike (S) protein receptor-binding domain (RBD). We discovered Nbs with picomolar to femtomolar affinities that inhibit viral infection at sub-ng/ml concentration and determined a structure of one of the most potent in complex with
RBD. Structural proteomics and integrative modeling revealed multiple distinct and non-overlapping epitopes and indicated an array of potential neutralization mechanisms. We constructed multivalent Nb constructs that achieved ultrahigh neutralization potency
(IC50s as low as 0.058 ng/ml) and may prevent mutational escape. These thermostable Nbs can be rapidly produced in bulk from microbes and resist lyophilization, and aerosolization. |
|
Effects of SARS-CoV-2 Infection on Male Sex-related Hormones in Recovering Patients |
Xu, H, Wang, et al |
Andrology |
Long-Term Sequelae |
|
To assess whether SARS-CoV-2 infection can affect sex-related hormones and testicular function in recovering patients.
The patients were separately classified according to the duration of viral shedding (long-term positive vs normal-term group, with the former cases having a duration >50 days) and disease severity (moderate vs severe group). A total of 39 COVID-19 patients
were included in this study. In males infected with SARS-CoV-2, most sex-related hormones (T, FSH and LH levels) remain within the normal reference ranges after recovery from COVID-19, and no significant associations were observed between T level and disease
duration or severity. |
|
Xu, Qinmei, Zhan, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We performed CT-based analysis combined with electronic health records and clinical laboratory results on Cohort 1
(n = 1662 from 17 hospitals) with prognostic estimation for the rapid stratification of PCR confirmed COVID-19 patients. These models, validated on Cohort 2 (n = 700) and Cohort 3 (n = 662) constructed from 9 external hospitals, achieved satisfying performance
for predicting ICU, MV and death of COVID-19 patients (AUROC 0.916, 0.919 and 0.853), even on events happened two days later after admission (AUROC 0.919, 0.943 and 0.856). Both clinical and image features showed complementary roles in events prediction and
provided accurate estimates to the time of progression (p<.001). Our findings are valuable for delivering timely treatment and optimizing the use of medical resources in the pandemic of COVID-19. |
|
|
Xu, X, Zeng, et al |
BMC Infect Dis |
Epidemiology| Épidémiologie |
The number of confirmed cases, daily growth, incidence and length of time from the first reported case to the end of
the local cases were compared by spatial and temporal classification and visualization of the development and changes of the epidemic situation by layers through maps. In the first wave, a total of 539 cases were reported in Sichuan, with an incidence rate
of 0.6462/100,000. The closer to Hubei the population centres were, the more pronounced the epidemic was. Eight weeks after the Wuhan lockdown, the health crisis had eased. The longest epidemic length at the city level in China (except Wuhan, Taiwan, and Hong
Kong) was 53 days, with a median of 23 days. Most countries outside China began to experience a rapid rise in infection rates 4 weeks after their first case. Some European countries experienced that rise earlier than the USA. The pandemic in Germany, Spain,
Italy, and China took 28, 29, 34, and 18 days, respectively, to reach the peak of daily infections, after their daily increase of up to 20 cases. During this time, countries in the African region and Southeast Asian region were at an early stage of infections,
those in the Eastern Mediterranean region and region of the Americas were in a rapid growth phase. |
|
|
Yan, F, Huang, et al |
Cell Discovery |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
In this multicenter retrospective study, we identified 2190 adult patients admitted for laboratory-confirmed COVID-19.
Multivariate logistic regression was conducted in patients with comorbid hypertension to examine the potential association between clinical outcomes, disease severity, and clinical characteristics with the use of ACEI, ARB, calcium-channel blockers (CCB),
beta-blockers (BB), and thiazide diuretics. The clinical outcome, dyspnea, and fatigue were significantly improved in patients, especially elderly patients who were older than 65 years, who took ARB drugs prior to hospitalization compared to patients who took
no drugs. The reduction of disease severity of elderly COVID-19 patients was associated with CCB and ACEI users. Clinical indices, including CRP, lymphocyte count, procalcitonin D dimer, and hemoglobin, were significantly improved in elderly ARB users. In
addition, the clinical outcomes were statistically significantly improved in patients who took antihypertension drugs ARB, BB, and CCB after statistical adjustment by all ages, gender, baseline of blood pressures, and coexisting medical conditions. |
|
|
Yang, C, Jiang, et al |
Emerg Microbes Infect |
Transmission Long-Term Sequelae |
|
We performed a population-based observational study to characterize the viral RNA level and serum antibody responses
in recurrent-positive patients and evaluate their viral transmission risk. Of 479 recovered COVID-19 patients, 93 (19%) recurrent-positive patients were identified, characterized by younger age, with a median discharge-to-recurrent-positive length of 8 days.
After readmission, recurrent-positive patients exhibited mild (28%) or absent (72%) symptoms, with no disease progression. The viral RNA level in recurrent-positive patients ranged from 1.8 to 5.7 log10 copies/mL. There are generally no significant differences
in antibody levels between recurrent-positive and non-recurrent-positive patients, or in recurrent-positive patients over time. Virus isolation of nine representative specimens returned negative results. Whole genome sequencing of six specimens yielded only
genomic fragments. 96 close contacts and 1,200 candidate contacts of 23 recurrent-positive patients showed no clinical symptoms. Recurrent-positive patients pose a low transmission risk, a relatively relaxed management of recovered COVID-19 patients is recommended. |
|
|
Yang, J, Pederson, et al |
J Appl Lab Med |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We evaluated the analytical and clinical performance of the Abbott SARS-CoV-2 IgG and the Roche Anti-SARS-CoV-2 immunoassays.
246 specimens from 70 patients with COVID-19 diagnosis were tested to study the sensitivity. 73 non-COVID-19 control specimens were measured to study the specificity. All specimens were analyzed by both assays. Total analytic variability (CV) of the negative
and positive controls were 5.5% and 3.6% for the Abbott assay and 4.5% and 1.9% for the Roche assay. Both assays demonstrated 100% qualitative reproducibility of negative and positive controls. The clinical specificities of the Abbott and the Roche assays
were 100% (95% CI: 94% - 100%) and 97% (95% CI: 90% - 100%), respectively. The clinical sensitivities of the Abbott assay were 49% (95% CI: 41% - 56%), 86% (95% CI: 74% - 93%) and 100% (95% CI: 76% - 100%) for samples collected at 0-6 days, 7-13 days and ≥14
days after the first RT-PCR, while the sensitivities of the Roche assay were 55% (95% CI: 47% - 62%), 86% (95% CI: 74% - 93%) and 100% (95% CI: 76% - 100%). |
|
|
Yao, H, Lu, et al |
Cell Discovery |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
We report the mutation spectrum, replication dynamics, and infectivity of 11 patient-derived viral isolates in diverse
cell lines, including the human lung cancer cell line Calu-3. We observed 46 mutations, including 9 different mutations in the spike gene. Importantly, these viral isolates show significant and consistent variations in replication dynamics and infectivity
in tested cell lines, up to a 1500-fold difference in viral titers at 24 h after infecting Calu-3 cells. We show that the variations in viral titers among viral isolates are positively correlated with blood clotting function but inversely correlated with the
amount of red blood cell and hemoglobin in patients. Therefore, we provide direct evidence that naturally occurring mutations in SARS-CoV-2 can substantially change its replication dynamics and infectivity in diverse human cell lines, with clinical implications
in vivo. |
|
|
Ye, W, Ye, et al |
Frontiers in Psychology |
Mental Health |
|
This cross-sectional, survey-based, region-stratified study collected demographic data and mental measurement from
2,498 medical students and 1,177 non-medical students in 31 provinces from March 5, 2020, to March 10, 2020, in China. The psychological stress was measured using the Chinese Perceived Stress Scales (CPSS) under a self-design questionnaire. Sociodemographic,
major characteristics, and knowledge of the novel coronavirus pneumonia were also identified as potential influencing factors of stress. The study revealed that medical students are suffering from more stress than non-medical students almost in all provinces
of China. Four influencing factors including level of familiarity with the novel coronavirus, family income, major of students, and status of the intern student can be significantly related to students’ stress in the medical group by using the univariate and
multivariate analysis. Further analysis showed that students with low stress had a greater number of positive psychological emotions and a lower number of negative psychological emotions than with medical students with high stress. In addition, high stress
caused low enthusiasm for learning in these medical students and lead to little/no willingness to do professional medical work in the future. |
|
|
Development and Validation of Early Warning Score
Systems for COVID-19 Patients |
Youssef, Alexey, Kouchaki, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We evaluated the ability of six common Early Warning Scores (EWS) to identify respiratory deterioration defined as
the need for advanced respiratory support (high-flow nasal oxygen, continuous positive airways pressure, non-invasive ventilation, intubation) within a prediction window of 24 hours in a retrospective cohort of patients with symptoms of COVID-19. We show these
scores perform sub-optimally at this specific task. Therefore, we develop an alternative Early Warning Score based on a Gradient Boosting Trees (GBT) algorithm that is able to predict deterioration within the next 24 hours with high AUROC 94% and an accuracy,
sensitivity and specificity of 70%, 96%, 70%, respectively. Our GBT model outperformed the best EWS (LDTEWS:NEWS), increasing the AUROC by 14%. Our GBT model makes the prediction based on the current and baseline measures of routinely available vital signs
and blood tests. |
|
A Workflow of Integrated Resources to Catalyze Network
Pharmacology Driven COVID-19 Research |
Zahoranszky-Kohalmi, Gergely, Siramshetty, et al |
bioRxiv |
Therapeutics| Thérapeutique |
Here, we describe a workflow we designed for a semi-automated integration of rapidly emerging datasets that can be
generally adopted in a broad network pharmacology research setting. The workflow was used to construct a COVID-19 focused multimodal network that integrates 487 host-pathogen, 74,805 host-host protein and 1,265 drug-target interactions. The resultant Neo4j
graph database named "Neo4COVID19" is accessible via a web interface and via API calls based on the Bolt protocol. We believe that our Neo4COVID19 database will be a valuable asset to the research community and will catalyze the discovery of therapeutics to
fight COVID-19 |
|
Zambrano, LD, Ellington, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This report provides updated information about symptomatic women of reproductive age (15-44 years) with laboratory-confirmed
infection with SARS-CoV-2, the virus that causes COVID-19. During January 22-October 3, CDC received reports through national COVID-19 case surveillance or through the National Notifiable Diseases Surveillance System (NNDSS) of 1,300,938 women aged 15-44 years
with laboratory results indicative of acute infection with SARS-CoV-2. Data on pregnancy status were available for 461,825 (35.5%) women with laboratory-confirmed infection, 409,462 (88.7%) of whom were symptomatic. Among symptomatic women, 23,434 (5.7%) were
reported to be pregnant. After adjusting for age, race/ethnicity, and underlying medical conditions, pregnant women were significantly more likely than were nonpregnant women to be admitted to an intensive care unit (ICU) (10.5 versus 3.9 per 1,000 cases;
adjusted risk ratio aRR] = 3.0; 95% confidence interval CI] = 2.6-3.4), receive invasive ventilation (2.9 versus 1.1 per 1,000 cases; aRR = 2.9; 95% CI = 2.2-3.8), receive extracorporeal membrane oxygenation (ECMO) (0.7 versus 0.3 per 1,000 cases; aRR = 2.4;
95% CI = 1.5-4.0), and die (1.5 versus 1.2 per 1,000 cases; aRR = 1.7; 95% CI = 1.2-2.4). |
|
|
Zandifar, A, Badrfam, et al |
Journal of Diabetes and Metabolic Disorders |
Mental Health |
|
In this cross-sectional study, 106 inpatients with COVID-19 who had stable clinical conditions were evaluated psychologically
by two questionnaires: Depression, Anxiety and Stress Scales-21 (DASS-21) and Perceived Stress Scale (PSS-4). More than one third of patients had underlying disease. Overall, 97.2% of patients with COVID-19 had some degree of depression. Severity of depression,
according to the DASS questionnaire, was 85.8%. All patients (100%) had severe (0.9%) and very severe (99.1%) anxiety. 97.1% of patients had some degree of stress. In the severity of stress category, 84.9% of patients had severe and very severe stress. In
terms of perceived stress, 73.6% of patients had high levels and 22.6% had moderate levels. A positive strong correlation was found between depression and perceived stress (Coefficient: 0.33, P-value: 0.001). Correlation between anxiety and perceived stress
was statistically significant (Coefficient: 0.2, P-value: 0.04). |
|
|
CoSinGAN: Learning COVID-19 Infection Segmentation from a Single Radiological
Image |
Zhang, P, Zhong, et al |
Diagnostics (Basel) |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We explore the feasibility of learning deep models for lung and COVID-19 infection segmentation from a single radiological
image by resorting to synthesizing diverse radiological images. Specifically, we propose a novel conditional generative model, called CoSinGAN, which can be learned from a single radiological image with a given condition, i.e., the annotation mask of the lungs
and infected regions. Our CoSinGAN is able to capture the conditional distribution of the single radiological image, and further synthesize high-resolution (512 × 512) and diverse radiological images that match the input conditions precisely. We evaluate the
efficacy of CoSinGAN in learning lung and infection segmentation from very few radiological images by performing 5-fold cross validation on COVID-19-CT-Seg dataset (20 CT cases) and an independent testing on the MosMed dataset (50 CT cases). Both 2D U-Net
and 3D U-Net, learned from four CT slices by using our CoSinGAN, have achieved notable infection segmentation performance, surpassing the COVID-19-CT-Seg-Benchmark, i.e., the counterparts trained on an average of 704 CT slices, by a large margin. Such results
strongly confirm that our method has the potential to learn COVID-19 infection segmentation from few radiological images in the early stage of COVID-19 pandemic. |
|
Zhu, Y, Chen, et al |
J Appl Psychol |
Mental Health |
|
In this study, we investigate the possibility that occupational calling fluctuates across days during situations of
crisis, and we identify antecedents and consequence of such fluctuations. To test our model, we conducted a daily diary study of 66 nurses working in intensive care units over 5 consecutive work days in a specialized Wuhan hospital that only admitted confirmed
COVID-19 patients during the peak of the pandemic in China. We found that the daily number of code blue events (i.e., cardiopulmonary resuscitation efforts with the primary goal of patient revival) was positively related to daily occupational calling for nurses.
Moreover, individual differences in prosocial motivation predicted the average level and variability of occupational calling over the 5 days, which subsequently related to the nurses' job performance. |
|
|
Zilla, M, Wheeler, et al |
Am J Clin Pathol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
Six SARS-CoV-2 antibody assays from Beckman Coulter, Euroimmun (IgG, IgA), Roche, and Siemens (Centaur, Vista) were
assessed for specificity (n = 184), sensitivity (n = 154), and seroconversion in a defined cohort with clinical correlates and molecular SARS-CoV-2 results. Assay specificity was 99% or greater for all assays except the Euroimmun IgA (95%). Sensitivity at
more than 21 days from symptom onset was 84%, 95%, 72%, 98%, 67%, and 96% for Beckman Coulter, Centaur, Vista, Roche, Euroimmun IgA, and Euroimmun IgG, respectively. Average day of seroconversion was similar between assays (8-10 d), with 2 patients not producing
nucleocapsid antibodies during hospitalization. SARS-CoV-2 nucleocapsid antibodies may be less reliably produced early in disease than spike protein antibodies. Assessment of convalescent plasma donors at more than 30 days from symptom onset and seroprevalence
studies should use assays with defined sensitivity at time points of interest because not all assays detected antibodies reliably at more than 30 days. |
|
|
Mathematical Models for COVID-19 Pandemic: A Comparative Analysis |
Adiga, A, Dubhashi, et al |
Journal of the Indian Institute of Science |
Review Literature| Revue de littérature |
|
|
Aggarwal, K, Agarwal, et al |
PLoS One |
Review Literature| Revue de littérature |
SR-MA: PubMed, Web of Science, CINAHL, OVID and Google scholar weres searched through 31st May 2020. The most common
reported ocular presentations of COVID-19 included ocular pain, redness, discharge, and follicular conjunctivitis. A small proportion of patients had viral RNA in their conjunctival/tear samples.
|
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|
Alanezi, F, Aljahdali, et al |
Journal of Healthcare Leadership |
Review Literature| Revue de littérature |
|
|
|
Al-Sayah, M |
Journal of water and health |
Review Literature| Revue de littérature |
|
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|
Antiochia, R |
Mikrochim Acta |
Review Literature| Revue de littérature |
|
|
|
The wide spectrum of Kawasaki-like disease associated with SARS-CoV-2 infection |
Berardicurti, O, Conforti, et al |
Expert Rev Clin Immunol |
Review Literature| Revue de littérature |
|
|
Coagulation disorders in covid-19: Role of toll-like receptors |
Biswas, I, Khan, et al |
Journal of Inflammation Research |
Review Literature| Revue de littérature |
|
|
Breman, J |
Indian Journal of Labour Economics |
Review Literature| Revue de littérature |
|
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Cachón-Zagalaz, J, Sánchez-Zafra, et al |
Frontiers in Psychology |
Review Literature| Revue de littérature |
SR: Web of Science (WOS), Scopus, and Dialnet databases were searched. After concluding the systematic review, it
has been detected that there are few studies that have focused their attention on the psychological, motor, or academic problems that can occur to minors after a situation of these characteristics. Similarly, a small number of studies have been found that
promote actions at the family and school level to reverse this situation when life returns to normal. |
|
|
Studies of Physical Activity and COVID-19 During the Pandemic: A Scoping Review |
Caputo, EL, Reichert, et al |
J Phys Act Health |
Review Literature| Revue de littérature |
ScR: A search in 6 databases (PubMed, Embase, SPORTDiscus, Scopus, Web of Science, and CINAHL) was conducted on July
23, 2020. Most of the evidence identified a decrease in PA levels due to social distancing measures and that PA might help to decrease the mental health burden related to the COVID-19 outbreak. |
|
Chueh, TI, Zheng, et al |
J Clin Med |
Review Literature| Revue de littérature |
|
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Deepika, V, Soundariya, et al |
Postgrad Med J |
Review Literature| Revue de littérature |
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Evaluation of the prophylaxis and treatment of COVID-associated coagulopathy |
Elbeddini, A, Gerochi, et al |
Journal of Pharmaceutical Policy and Practice |
Review Literature| Revue de littérature |
|
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Treatment considerations for Behçet's disease in the era of COVID-19: a narrative review |
Elmas Ö, F, Demirbaş, et al |
Dermatol Ther |
Review Literature| Revue de littérature |
|
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Physical Exercise and the Renin Angiotensin System: Prospects in the COVID-19 |
Evangelista, FS |
Frontiers in Physiology |
Review Literature| Revue de littérature |
|
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Cultural and Practical Implications for Psychiatric Telehealth Services: A Response to COVID-19 |
Goldin, D, Maltseva, et al |
J Transcult Nurs |
Review Literature| Revue de littérature |
|
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Unveiling the diversity of scholarly debate on living labs: A bibliometric approach |
Greve, K, Leminen, et al |
International Journal of Innovation Management |
Review Literature| Revue de littérature |
|
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Han, X, Ye, et al |
J Med Virol |
Review Literature| Revue de littérature |
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COVID-19 and COPD: a narrative review of the basic science and clinical outcomes |
Higham, A, Mathioudakis, et al |
Eur Respir Rev |
Review Literature| Revue de littérature |
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Hoang, T, Thi Anh, et al |
Infection and Chemotherapy |
Review Literature| Revue de littérature |
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Hoang, VT, Al-Tawfiq, et al |
Current Tropical Medicine Reports |
Review Literature| Revue de littérature |
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Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields |
Huan, Y, Kong, et al |
Frontiers in Microbiology |
Review Literature| Revue de littérature |
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Jain, S, Batra, et al |
Vaccines (Basel) |
Review Literature| Revue de littérature |
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Kiss, P, Carcel, et al |
Eur Heart J Qual Care Clin Outcomes |
Review Literature| Revue de littérature |
SR: PubMed, MedRxiv and Google Scholar were searched for observational studies published up to August 12, 2020. The
COVID-19 pandemic has led to a substantial decrease in the rate of admissions for acute CVD, reductions in the number of procedures, shortened lengths of stay at the hospital and longer delays between the onset of the symptoms and hospital treatment.
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Universal anti-influenza vaccines based on viral HA2 and M2e antigens |
Kostolanský, F, Tomčíková, et al |
Acta Virol |
Review Literature| Revue de littérature |
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Labrague, Leodoro |
medRxiv |
Review Literature| Revue de littérature |
SR: PubMed, CINAHL, SCOPUS, MEDLINE and PsychINFO were searched. Substantial evidence supports the effectiveness of
coping behaviours, psychological resilience, and social support to preserve psychological and mental health among HCWs during the COVID-19 pandemic.
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Lee, K, Jeong, et al |
Int J Environ Res Public Health |
Review Literature| Revue de littérature |
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Nanomaterials for Airborne Virus Inactivation: A Short Review |
Li, R, Cui, et al |
Aerosol Science and Engineering |
Review Literature| Revue de littérature |
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A review of neuro-ophthalmological manifestations of human coronavirus infection |
Luís, ME, Hipólito-Fernandes, et al |
Eye and Brain |
Review Literature| Revue de littérature |
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PMC7643523; A public health timeline to prepare for COVID-19 vaccines in Canada |
MacDonald, NE, Comeau, et al |
Can J Public Health |
Review Literature| Revue de littérature |
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An overview on the use of antivirals for the treatment of patients with COVID19 disease |
Malinis, M, McManus, et al |
Expert Opin Investig Drugs |
Review Literature| Revue de littérature |
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Mascolo, S, Carleo, et al |
J Med Virol |
Review Literature| Revue de littérature |
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Mekonnen, D, Mengist, et al |
Rev Med Virol |
Review Literature| Revue de littérature |
SR-MA: MEDLINE through PubMed, Scopus, medRxiv and bioRxiv were sources of articles. As immunoglobulin isotope-related
DTA was heterogeneous, our data have insufficient evidence to recommend CLIA/ELISA for clinical decision-making, but likely to have comparative advantage over RT-qPCR in certain circumstances and geographic regions. |
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Nugraha, RV, Ridwansyah, et al |
Evidence-based Complementary and Alternative Medicine |
Review Literature| Revue de littérature |
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The shadow pandemic: Inequitable gendered impacts of COVID-19 in South Africa |
Parry, BR, Gordon, et al |
Gender, Work and Organization |
Review Literature| Revue de littérature |
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PMC7641654; Social Determinants of Poor Management of Type 2 Diabetes Among the Insured |
Patel, MR |
Curr Diab Rep |
Review Literature| Revue de littérature |
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Pollock, A, Campbell, et al |
Cochrane Database Syst Rev |
Review Literature| Revue de littérature |
SR: On 28 May 2020 we searched the Cochrane Database of Systematic Reviews, CENTRAL, MEDLINE, Embase, Web of Science,
PsycINFO, CINAHL, Global Index Medicus databases and WHO Institutional Repository for Information Sharing. We also searched ongoing trials registers and Google Scholar.
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Salzberger, B, Buder, et al |
Gastroenterologe |
Review Literature| Revue de littérature |
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Shirani, F, Khorvash, et al |
International Journal of Food Properties |
Review Literature| Revue de littérature |
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The COVID-19 Pandemic: An Unprecedented Tragedy in the Battle Against Childhood Obesity |
Storz, MA |
Clin Exp Pediatr |
Review Literature| Revue de littérature |
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MATH+ and I-MASK+ Protocols for Prevention and Treatment of
All Phases of COVID-19 – A Short Review |
Turkia, Mika |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
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Veronin, MA, Lang, et al |
Journal of Pharmacy Technology |
Review Literature| Revue de littérature |
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Wang, YF, Militky, et al |
|
Review Literature| Revue de littérature |
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Wong, A, Olusanya, et al |
Journal of the Intensive Care Society |
Review Literature| Revue de littérature |
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Ye, L, Yang, et al |
J Gastroenterol Hepatol |
Review Literature| Revue de littérature |
SR: searched PubMed database and Google articles published in both English and Chinese up to June 3, 2020. GI symptoms
are common in COVID-19. Strengthening the recognition on abnormalities in digestive system of patients with COVID-19 is crucial for early identification and timely treatment, especially for those atypical patients. Hygiene protection and keep drainpipe free-flowing
are necessary for everyone. |
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Remdesivir in COVID-19 management: availability and relevance to low- and middle-income countries |
Adhikari, S, Khadka, et al |
Drugs and Therapy Perspectives |
Commentary/Editorial| Commentaire/Éditorial |
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Agrawal, P |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Alberca, RW, Andrade, et al |
Frontiers in Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Alderman, Joseph |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Aldrich, AS, Lotito, et al |
Politics and Gender |
Commentary/Editorial| Commentaire/Éditorial |
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Framework for curriculum delivery during COVID-19 pandemic in a health sciences university |
Al-Kadri, H, Al Moamary, et al |
Annals of Thoracic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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33097101; The Impact of COVID-19 within Academic Settings: A High-Speed Pivot |
Almost, J |
Nursing leadership (Toronto, Ont.) |
Commentary/Editorial| Commentaire/Éditorial |
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Al-Shamsi, H, Coomes, et al |
JAMA Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Altshuler, E |
BMJ Leader |
Commentary/Editorial| Commentaire/Éditorial |
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33094936; Who should we treat: elective surgical admissions or patients with COVID-19? |
Antkowiak, PS, Cocchi, et al |
The American Journal of Managed Care |
Commentary/Editorial| Commentaire/Éditorial |
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Arantes, PR, Saha, et al |
ACS Central Science |
Commentary/Editorial| Commentaire/Éditorial |
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Ardestani, A, Maedler, et al |
Frontiers in Endocrinology |
Commentary/Editorial| Commentaire/Éditorial |
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Arias, F, Safi, et al |
Arch Clin Neuropsychol |
Commentary/Editorial| Commentaire/Éditorial |
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Fiscal solidarity: The conditional role of political knowledge |
Armingeon, K |
European Union Politics |
Commentary/Editorial| Commentaire/Éditorial |
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Mini-Lectures Interleaved with Exercises Found Beneficial in Online Learning |
Au, OTS |
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Commentary/Editorial| Commentaire/Éditorial |
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[Pregnancy care during COVID-19 epidemic, a drive for change?] |
Baena-Antequera, F, Jurado-García, et al |
Rev Esp Salud Publica |
Commentary/Editorial| Commentaire/Éditorial |
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Bahado-Singh, R, Hassan, et al |
J Perinat Med |
Commentary/Editorial| Commentaire/Éditorial |
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Banysch, M, Heuer, et al |
Gastroenterologe |
Commentary/Editorial| Commentaire/Éditorial |
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Sitagliptin: a potential drug for the treatment of COVID-19? |
Bardaweel, SK, Hajjo, et al |
Acta Pharm |
Commentary/Editorial| Commentaire/Éditorial |
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33095546; Lessons Learned from the COVID-19 Pandemic for Pediatric Workplaces |
Beal, JA |
MCN.The American journal of maternal child nursing |
Commentary/Editorial| Commentaire/Éditorial |
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The pandemic of pictures: Visual and bio-political rhetoric of a world marked by covid-19 |
Beiguelman, G |
Revista Latinoamericana de Psicopatologia Fundamental |
Commentary/Editorial| Commentaire/Éditorial |
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Béland, D, Dinan, et al |
Social Policy and Administration |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 pandemic as disjuncture: Lifelong learning in a context of fear |
Bjursell, C |
International Review of Education |
Commentary/Editorial| Commentaire/Éditorial |
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Did Targeting Financial Constraints During COVID-19 Make Sense? |
Boddin, Dominik, D'Acunto, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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33103512; The probiotic Bifidobacterium in the management of Coronavirus: A theoretical basis |
Bozkurt, HS, Quigley, et al |
International Journal of Immunopathology and Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Burns, D, Dagnall, et al |
Frontiers in Education |
Commentary/Editorial| Commentaire/Éditorial |
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Capoulade, F, Pereira, et al |
Revista Latinoamericana de Psicopatologia Fundamental |
Commentary/Editorial| Commentaire/Éditorial |
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Carneiro-Leão, L, Amaral, et al |
Journal of Allergy and Clinical Immunology: In Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Centor, RM, Andrews, et al |
Ann Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Chandler-Grevatt, A |
Education in Chemistry |
Commentary/Editorial| Commentaire/Éditorial |
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Caution in Interpretation of Abnormal Carbon Monoxide Diffusion Capacity in COVID-19 Patients |
Chapman, DG, Badal, et al |
Eur Respir J |
Commentary/Editorial| Commentaire/Éditorial |
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Chauhan, Anil, Agarwal, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Choukér, A, Stahn, et al |
npj Microgravity |
Commentary/Editorial| Commentaire/Éditorial |
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Clatworthy, L |
Education in Chemistry |
Commentary/Editorial| Commentaire/Éditorial |
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Collaborative, OVIDS C |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Mass Air Medical Repatriation of Coronavirus Disease 2019
Patients |
Cornelius, B, Cornelius, et al |
Air Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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The psychopathology of the pandemic: Literature, science and politics |
D‘agord, MRL, Lang, et al |
Revista Latinoamericana de Psicopatologia Fundamental |
Commentary/Editorial| Commentaire/Éditorial |
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Grief in the times of COVID-19: Challenges to mental health care during the pandemics |
Dantas, CR, de Azevedo, et al |
Revista Latinoamericana de Psicopatologia Fundamental |
Commentary/Editorial| Commentaire/Éditorial |
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Daunt, A, Perez-Guzman, et al |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
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Writing, memory and care – health workers testimonies in times of pandemic |
de Serpa, OD, Jr, et al |
Revista Latinoamericana de Psicopatologia Fundamental |
Commentary/Editorial| Commentaire/Éditorial |
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Sex differences in COVID-19 case fatality: do we know enough? |
Dehingia, Nabamallika, Raj, et al |
The Lancet Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection? |
Delorme-Axford, E, Klionsky, et al |
Autophagy |
Commentary/Editorial| Commentaire/Éditorial |
|
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Remodeling dentistry and dental technologies after coronavirus disease 2019 (COVID-19) |
Dhar, U, Nagarajappa, et al |
Journal of Oral Research |
Commentary/Editorial| Commentaire/Éditorial |
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Dyer, C |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Strategy, coordinated implementation, and sustainable financing needed for COVID-19 innovations |
Dzau, VictorJ, Balatbat, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
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AI Transforming Healthcare Management during COVID-19 Pandemic |
Efthymiou, Panagiota Iris-, Sidiropoulos, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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El-Taliawi, O, Hartley, et al |
Journal of Contingencies and Crisis Management |
Commentary/Editorial| Commentaire/Éditorial |
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33102152; SARS-CoV-2 infection in pregnant women and their newborns |
Etti, M, Sekikubo, et al |
Annals of Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Faheem, S, Militky, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Falk, J, Colwell, et al |
Sustainability Science |
Commentary/Editorial| Commentaire/Éditorial |
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Why asthma might surprisingly protect against poor outcomes in COVID-19 |
Farne, H, Singanayagam, et al |
Eur Respir J |
Commentary/Editorial| Commentaire/Éditorial |
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Ferrari, IF, Januzzi, et al |
Revista Latinoamericana de Psicopatologia Fundamental |
Commentary/Editorial| Commentaire/Éditorial |
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Fiorenza, N |
IHS Jane's Defence Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Intravenous immunoglobulin immunotherapy for coronavirus disease-19 (COVID-19) |
Galeotti, C, Kaveri, et al |
Clinical and Translational Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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The Importance of Telemedicine during COVID-19 Pandemic: A Focus on Diabetic Retinopathy |
Galiero, R, Pafundi, et al |
Journal of Diabetes Research |
Commentary/Editorial| Commentaire/Éditorial |
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García-Sánchez, IM, García-Sánchez, et al |
Journal of Open Innovation: Technology, Market, and Complexity |
Commentary/Editorial| Commentaire/Éditorial |
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Gärtner, P |
Nachrichten aus der Chemie |
Commentary/Editorial| Commentaire/Éditorial |
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George, Thukalan Paulose |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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The Effect of a Major Pandemic on Risk Preferences - Evidence
from Exposure to COVID-19 |
Graeber, Daniel, Schmidt, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Grannemann, JJ, Röper, et al |
Pneumologie |
Commentary/Editorial| Commentaire/Éditorial |
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Severity in pediatric type 1 diabetes mellitus debut during the COVID-19 pandemic |
Güemes, M, Storch-de-Gracia, et al |
J Pediatr Endocrinol Metab |
Commentary/Editorial| Commentaire/Éditorial |
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Gupta, Abhishek |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Hamid, HythamKS |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Reporting on suicidal behaviour and COVID-19—need for caution |
Hawton, Keith, Marzano, et al |
The Lancet Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Hegde, M, Qaiser, et al |
Journal of Conservative Dentistry |
Commentary/Editorial| Commentaire/Éditorial |
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Hernández-Zelaya, SL, Peláez-Muñoz, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
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Hippisley-Cox, J, Tan, et al |
Heart |
Commentary/Editorial| Commentaire/Éditorial |
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Hoffmann, Christian, Wolf, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Horton, Richard |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Hu, S, Wang, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
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Early triple antiviral therapy for COVID-19 – Authors' reply |
Hung, Ivan Fan-Ngai, Yuen, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: NHS is placed on highest alert level as intensive care beds fill up |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Iversen, J, Sabin, et al |
Journal of the International AIDS Society |
Commentary/Editorial| Commentaire/Éditorial |
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Hypoxia: A key feature of COVID-19 launching activation of HIF-1 and cytokine storm |
Jahani, M, Dokaneheifard, et al |
Journal of Inflammation (United Kingdom) |
Commentary/Editorial| Commentaire/Éditorial |
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Jenkins, R, Burke, et al |
MMWR Morb Mortal Wkly Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Understanding the Epidemic Course in Order to Improve Epidemic Forecasting |
Jia, P |
GeoHealth |
Commentary/Editorial| Commentaire/Éditorial |
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Jorge, April |
The Lancet Rheumatology |
Commentary/Editorial| Commentaire/Éditorial |
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Fear, perplexity, negationism, consternation – and grief: Affects of the subject during the
pandemic |
Jorge, MAC, Mello, et al |
Revista Latinoamericana de Psicopatologia Fundamental |
Commentary/Editorial| Commentaire/Éditorial |
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Kan, JYL, Zhu, et al |
Medical Science Educator |
Commentary/Editorial| Commentaire/Éditorial |
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Kang, CM |
Annals of Surgical Treatment and Research |
Commentary/Editorial| Commentaire/Éditorial |
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Kardashian, A, Wilder, et al |
Hepatology |
Commentary/Editorial| Commentaire/Éditorial |
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Kasaven, LS, Saso, et al |
Bjog |
Commentary/Editorial| Commentaire/Éditorial |
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Wie effektiv waren Distanzierungsmaβnahmen in der COVID-19-Pandemie bislang? |
Klein, F |
Deutsche medizinische Wochenschrift |
Commentary/Editorial| Commentaire/Éditorial |
|
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Platelets and COVID-19: Inflammation, Hyperactivation and Additional Questions |
Koupenova, M, Freedman, et al |
Circ Res |
Commentary/Editorial| Commentaire/Éditorial |
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Pandemic sex workers’ resilience: COVID-19 crisis met with rapid responses by sex worker communities |
Lam, E |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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Measures to overcome the negative impacts of COVID-19 on the mental health of dentists |
Laureano, ICC, Cavalcanti, et al |
Journal of Oral Research |
Commentary/Editorial| Commentaire/Éditorial |
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Lee, Nelson, Ison, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Clustering cases of Chlamydia psittaci pneumonia in COVID-19 screening ward staff |
Lei, JH, Xu, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Student-led action during COVID-19: Countering discrimination at school |
Lencz, IÁ, Hancock, et al |
Intercultural Education |
Commentary/Editorial| Commentaire/Éditorial |
|
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Covid-19: Experts debate merits of lockdowns versus "focused protection" |
Lenzer, J |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Rapid Development of a Hospital Checklist in a Time of COVID-19 |
Lintern, G, Motavalli, et al |
Ergonomics in Design |
Commentary/Editorial| Commentaire/Éditorial |
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Lodge, Archie |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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How discourses of gender equity during COVID-19 become exclusionary: Lessons from parenthood |
Lorello, GR, Kuper, et al |
J Eval Clin Pract |
Commentary/Editorial| Commentaire/Éditorial |
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Lu, F, Chen, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Understanding COVID-19: In the end it is the endothelium-what else? |
Lüscher, TF |
European heart journal |
Commentary/Editorial| Commentaire/Éditorial |
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Malik, SI, Ahmed, et al |
Psychology Research and Behavior Management |
Commentary/Editorial| Commentaire/Éditorial |
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Markham, AN, Harris, et al |
Qualitative Inquiry |
Commentary/Editorial| Commentaire/Éditorial |
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Mayer, M, Cocco, et al |
Public Works Management and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Meecham, Lewis, Shakarchi, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Mildon, B |
Nursing leadership (Toronto, Ont.) |
Commentary/Editorial| Commentaire/Éditorial |
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A Testimony of the Surgent SARS-CoV-2 in the Immunological Panorama of the Human Host |
Minakshi, R, Jan, et al |
Frontiers in Cellular and Infection Microbiology |
Commentary/Editorial| Commentaire/Éditorial |
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Mohebbi, N, Abedini, et al |
Advances in Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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What could fair allocation of an efficacious COVID-19 vaccine look like in South Africa? |
Moodley, Keymanthri, Rossouw, et al |
The Lancet Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Morales, I |
Latin American Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Morrissey, H, Ball, et al |
Br J Haematol |
Commentary/Editorial| Commentaire/Éditorial |
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Collateral Damage as Crises Collide: Perioperative Opioids in the COVID-19 Era |
Mudumbai, SC, Mariano, et al |
Pain Med |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus Pandemic - SARS-CoV-2 in Orthopedics and Trauma Surgery |
Müller, M, Stöckle, et al |
Z Orthop Unfall |
Commentary/Editorial| Commentaire/Éditorial |
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Musavengane, R, Leonard, et al |
Development Southern Africa |
Commentary/Editorial| Commentaire/Éditorial |
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Muula, AS |
Malawi Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Nagle, LM |
Nursing leadership (Toronto, Ont.) |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 pandemic in Brazil: Searching for meaning in the midst of a tragedy |
Oda, AMGR, Leite, et al |
Revista Latinoamericana de Psicopatologia Fundamental |
Commentary/Editorial| Commentaire/Éditorial |
|
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Natural Plant Products: A Less Focused Aspect for the COVID-19 Viral Outbreak |
Pandey, A, Khan, et al |
Frontiers in Plant Science |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pandey, BN |
Annals of Thoracic Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Parmar, MS |
Nephrology (Carlton) |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19, big data: how it will change the way WE practice medicine |
Pasipoularides, A |
Qjm |
Commentary/Editorial| Commentaire/Éditorial |
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Peinado, M, Anderson, et al |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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33039648; Ten Rules for Implementation of a Telemedicine Program to Care for Patients with Asthma |
Persaud, YK, Portnoy, et al |
Journal of Allergy and Clinical Immunology: In Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Petrosillo, N |
Infectious Disease Reports |
Commentary/Editorial| Commentaire/Éditorial |
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Pio, E, Waddock, et al |
Management Learning |
Commentary/Editorial| Commentaire/Éditorial |
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Ploumpidis, D |
Psychiatrike = Psychiatriki |
Commentary/Editorial| Commentaire/Éditorial |
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Pollán, Marina, Pérez-Gómez, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Pandemic and Cancer: The Importance of Early Palliative Care |
Potenza, L, Luppi, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Preisser, AM, Pieter, et al |
Zentralblatt fur Arbeitsmedizin, Arbeitsschutz und Ergonomie |
Commentary/Editorial| Commentaire/Éditorial |
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AJNR Am J Neuroradiol |
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Qi, F, Wang, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Study and practice on hand-made
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Commentary/Editorial| Commentaire/Éditorial |
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Evidence suggests children are being left behind in COVID-19 mental health research |
Racine, N, Korczak, et al |
Eur Child Adolesc Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Raoufi, M, Fayek, et al |
Public Works Management and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Rapisarda, SS, Byrne, et al |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
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A Framework for Improving Policy Priorities in Managing COVID-19 Challenges in Developing Countries |
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Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Reinders, C |
Pharmaceutisch weekblad |
Commentary/Editorial| Commentaire/Éditorial |
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Reischl, U |
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Making the Case for Centralized Dementia Care Through Adaptive Reuse in the Time of COVID-19 |
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Inquiry (United States) |
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Rodrigues, Jeremy, Chan, et al |
The Lancet |
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Sadayappan, S, Tardiff, et al |
Circ Res |
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Sahlberg, P |
Educational Research for Policy and Practice |
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Therapeutic Advances in Endocrinology and Metabolism |
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Rev Esp Salud Publica |
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The COVID-19 Pandemic: A Pandemic of Lockdown Loneliness and the Role of Digital Technology |
Shah, SGS, Nogueras, et al |
J Med Internet Res |
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Shanthanna, Harsha, Uppal, et al |
The Lancet |
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Nat Biotechnol |
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Circulation |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.*
Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.
Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers.
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Séquelles à long terme:
Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.
Santé mentale:
Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées
à la pandémie.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives