Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19,
2020-11-06
Good afternoon,
There are 486 citations in today’s scan. 260 were considered primary research or review literature.
Highlights today include:
CANADA
·
Mills, J.,
develops a SEIRCRT model that integrates the Institute for Disease Modeling’s SEIR model and Critical Race Theory (CRT). SEIRCRT provides a basic modeling structure from a CRT lens to simulate, predict and forecast COVID-19 cases, comorbidities affecting
African Canadians, and deaths through predictive modeling.
TRANSMISSION
·
Murphy et al
report an outbreak of 59 cases of coronavirus disease (COVID-19) originated with 13 cases linked by a 7 h, 17% occupancy flight into Ireland, summer 2020. The flight-associated attack rate was 9.8–17.8%. Spread to 46 non-flight cases occurred country-wide.
Asymptomatic/pre-symptomatic transmission in-flight from a point source is implicated by 99% homology across the virus genome in five cases travelling from three different continents.
IMMUNOLOGY
·
Gaebler et al.
find that IgM, and IgG anti-SARS-CoV-2 spike protein receptor binding domain (RBD) antibody titers decrease significantly with IgA being less affected. Memory B cells display clonal turnover after 6.2 months and
intestinal biopsies obtained from asymptomatic individuals 3 months after COVID-19 onset, revealed persistence of SARS-CoV-2 in the small bowel of 7 out of 14 volunteers.
EPIDEMIOLOGY
·
Jablonska, Aballea, & Toumi
The purpose of this study was to determine predictors of the height of COVID-19 daily deaths peak and time to the peak, in order to explain their variability across European countries. The analysis demonstrated that countries
with higher proportions of the population living in urban areas, with lower reduction in mobility at the beginning of the pandemic, and countries which closed borders having more infected people experienced higher peak of COVID-19 deaths.
·
Cai et al
compared the epidemiological and clinical features of the symptomatic and asymptomatic pediatric cases of COVID-19. The mean duration of viral shedding for SARS-CoV-2 in upper respiratory tract was 14.1 days in asymptomatic cases and 14.8 days in symptomatic
cases. Children < 7 years shed viral RNA in stool for a longer duration than school-aged children (P < 0.05). Forty-three (87.8%) cases had seropositivity for antibodies against SARS-CoV-2 within 1-3 weeks after confirmation with infection.
·
Shah et al
determine the effect of baseline use of angiotensin-converting enzyme inhibitor (ACE-i)/AT1 blocker (ARB) on mortality in hospitalized coronavirus disease 2019 (Covid-19) African-American patients. Patients were divided into two groups, those on ACE-i/ARB
at baseline and those not on them. After adjustment of multiple covariates, there was no difference in outcomes between the two groups including mortality, need for mechanical ventilation, new dialysis, ICU care, as well as composite outcomes.
CLINICAL DATA
·
Vilke et al. assessed the frequency of a fever ≥100.4°F and other symptoms associated with COVID-19 among patients in the emergency department
(ED). A total of 6894 patients were tested for COVID-19 and 4.8% tested positive for active infection. Of those who tested positive, 19.4% presented with a fever ≥100.4°F. Approximately one quarter of those who tested positive did not have a fever at presentation.
The authors concluded that using temperature to screen for COVID-19 in the community setting will likely miss the majority of patients with active infection.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura
Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics /
Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance,
Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, Immunologie,
économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
|
PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Hypoxemia and prone position in mechanically ventilated Covid-19 patients: a prospective cohort study |
Abou-Arab, O, Haye, et al |
Can J Anaesth |
Clinical data| Données cliniques |
The aim of the study was to report the effects of prone position (PP) in mechanically ventilated patients with COVID-19
related ARDS. Between March 1st and April 30th, we prospectively included all patients admitted to our ICU with COVID-19 related acute respiratory failure. 64 (91%) received invasive mechanical ventilation during the course of the disease. Respiratory parameters
were recorded before and at the end of the first 16-hour PP session for 25 patients that were analyzed. This study suggests that PP may improve oxygenation without any changes in ventilatory parameters highlighting the possible role of a hidden intra-pulmonary
shunt. Further investigations are mandatory before any formal conclusion. |
|
Affes, Z, Bouvard, et al |
J Clin Neurophysiol |
Clinical data| Données cliniques |
A 78-year-old man was admitted for acute confusion. At initial investigation physical examination, blood and cerebrospinal fluid tests were unremarkable
and EEG showed synchronous bifrontal periodic discharges, an evocative pattern of encephalitis. Coronavirus disease 2019 was diagnosed later after fever onset. Isolated mild confusion may thus be an initial clinical picture of Coronavirus disease 2019 infection. |
|
|
Reducing chances of COVID-19 infection by a cough cloud in a closed space |
Agrawal, A, Bhardwaj, et al |
Physics of Fluids |
Modelling/ prediction| Modélisation/prédiction Transmission |
In the present work, we estimate this volume of the air, which may help us to design ventilation of closed spaces and, consequently, reduce the spread
of the disease. We analyze data to estimate the volume of the cough-cloud in the presence and absence of a face mask. The volume of the cough-cloud without a mask is about 7 and 23 times larger than in the presence of a surgical mask and an N95 mask, respectively.
We also find that the cough-cloud is present for 5 s-8 s, after which the cloud starts dissipating, irrespective of the presence or absence of a mask. |
|
Ahamad, S, Kanipakam, et al |
European journal of pharmacology |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The study aimed to identify promising lead molecules against SARS-CoV-2 Main protease (Mpro) enzyme through virtual screening of Malaria Venture (MMV)
Malaria Box (MB) comprising of 400 experimentally proven compounds. The binding affinities were studied using virtual screening based molecular docking, which revealed five molecules having the highest affinity scores compared to the reference molecules. The
molecular dynamics (MD) simulation trajectories were analysed to monitor protein deviation, relative fluctuation, atomic gyration, compactness covariance, residue-residue map and free energy landscapes. Based on the outcome, we propose three Malaria_box (MB)
compounds, namely, MB_241, MB_250 and MB_266 to be the best lead compounds against Mpro activity. |
|
|
Ahmad, J, Anwar, et al |
Disaster Med Public Health Prep |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé Immunology | Immunologie |
This study aimed to assess the Impact of PPE availability, training and practices on COVID-19 sero-prevalence among nurses and paramedics in teaching hospitals
of Peshawar, Pakistan. A cross-sectional survey was conducted with a total of 133 nurses and paramedics as subjects of the study. The findings indicate that the healthcare professionals who have received PPE on time at the start of COVID-19 emergence has fewer
chances of contracting the COVID-19 infection (O.R = 0.96); while the odds for PPE supplies was 0.73, and the odds of hand hygiene training was 0.95. Sero-positivity in nurses and paramedics were 48% (n=23) and 41% (n=35). The study concluded that the availability
of the PPE, COVID-19 related training and compliance with W.H.O recommended practices against COVID-19 were instrumental in protection against the infection and its spread. |
|
|
Akinci, M, Bozkurt, et al |
Signa Vitae |
Healthcare Response | Réponse des soins de santé |
In the present study we analyze the outcomes of patients who have undergone elective colorectal surgery in our hospital
since the COVID-19 outbreak, as well as the precautionary procedural changes that have been made. It was established in the present study that patients undergoing colorectal surgery and patients with COVID-19 infections in the same hospital can be treated
successfully without cross-infection through the application of appropriate isolation principles. These successful findings were supported by a 14-day follow-up after discharge. |
|
|
Grim Situation of the World Due to COVID-19: Economic Perspective |
Ali, Muhammad Mahboob |
SSRN- Lancet prepublication |
Economics | Économie |
The study tried to get a conceptual view for time demanding collaborative effort among the global arena so that this
pandemic cannot make long-lasting devastating impact on global economy. The study also did a small opinion poll survey by email/cell phone, land phone, and personally asking by maintaining social distance among 108 respondents considering three segments of
the income strata of the people in Bangladesh. |
|
Annweiler, G, Corvaisier, et al |
Nutrients |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The objective of this quasi-experimental study was to determine whether bolus vitamin D supplementation taken either
regularly over the preceding year or after the diagnosis of COVID-19 was effective in improving survival among hospitalized frail elderly COVID-19 patients. Intervention groups were participants regularly supplemented with vitamin D over the preceding year
(Group 1), and those supplemented with vitamin D after COVID-19 diagnosis (Group 2). The comparator group involved participants having received no vitamin D supplements (Group 3). In Group 1 (n = 29), 93.1% of COVID-19 participants survived at day 14, compared
to 81.2% survivors in Group 2 (n = 16) (p = 0.33) and 68.7% survivors in Group 3 (n = 32) (p = 0.02). Regular bolus vitamin D supplementation was associated with less severe COVID-19 and better survival in frail elderly. |
|
|
Awareness and role of dentist
in preventing covid-19 outbreak-a survey |
Anushya, P, Prathap, et al |
International Journal of Pharmaceutical Research |
Healthcare Response | Réponse des soins de santé |
The aim of the study is to assess the awareness about the role of dental professionals in preventing the outbreak of
Covid-19. The study population included 200 dental professionals. 75.38% of dental professionals correctly answered the incubation period of Covid-19. Only 11.5% of dental professionals reported that they would take strict disinfection measures only in clinics
whereas 88.5% of dentists responded that they would take preventive measures in both clinical settings and public areas. |
|
Arsandaux, Julie, Montagni, et al |
medRxiv |
Mental Health |
|
The objective of this study was to estimate the effect of student status on mental health conditions during Covid-19
general lockdown among adults in France. Among the 2260 included participants, students represented 59% (n=1335 vs 925 non-students) and 78% of the total sample were female. Student status was more frequently associated with depressive symptoms (adjusted OR(aOR)=1.58;
95%CI 1.17;2.14), anxiety symptoms (aOR=1.51; 95%CI 1.10;2.07), perceived stress (n=1919, aOR=1.70, 95%CI 1.26;2.29) and frequent suicidal thoughts (n=1919, aOR=1.57, 95%CI 0.97;2.53). Follow-up and interventions should be implemented especially for those
at high-risk. |
|
|
Arshad Ali, S, Azim, et al |
Transfusion Clinique et Biologique |
Healthcare Response | Réponse des soins de santé |
This study aimed to assess the impact of the COVID-19 on blood transfusion therapy (BTT) of thalassemia patients and
suggest ways to ensure safe and reliable blood supplies amid such health crises. A retrospective, cross-sectional study was conducted from October 2019 (before COVID-19) to July 2020 (during COVID-19) based on the data provided by a thalassemia center, named
Help International Welfare Trust, Karachi, Pakistan. There was a significant reduction in the consumption of PRBCs bags after the emergence of COVID-19 (P = 0.002). Moreover, the number of thalassemia patients receiving BTT was dropped by 10.56% during the
pandemic. There was a strong negative correlation observed between the rising cases of COVID-19 in Pakistan and the number of patients missing their therapy sessions (r = −0.914, P = 0.030). A considerable decline in the reserves of all Rhesus-negative blood
groups amid the COVID-19 outbreak was also observed. |
|
|
Asfahan, S, Gopalakrishnan, et al |
Advances in Respiratory Medicine |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We demonstrate the application of a simple automated machine learning algorithm to a dataset obtained about COVID-19
spread in South Korea. Data from 20th January 2020 to 4th March 2020 was accessed from Korea’s centre for disease control (KCDC). A future time-series of specified length (taken as 7 days in our study) starting from 5th March 2020 to 11th March 2020 was generated
and fed to the model to generate predictions with upper and lower trend bounds of 95% confidence intervals. The model was assessed for its ability to reliably forecast using mean absolute percentage error (MAPE) as the metric. As on 4th March 2020, 145,541
patients were tested for COVID-19 (in 45 days) in South Korea of which 5166 patients tested positive. The predicted values approximated well with the actual numbers. The difference between predicted and observed values ranged from 4.08% to 12.77%. On average,
our predictions differed from actual values by 7.42% (MAPE) over the same period. |
|
|
Asmelash, D, Fasil, et al |
Risk Management and Healthcare Policy |
Public Health response| Interventions de santé publique |
A community-based cross-sectional study was conducted to determine knowledge, attitudes and practices towards COVID-19
and its associated factors among religious clerics and traditional healers in Gondar town. A total of 410 religious clerics and traditional healers were included in the study with a survey response rate of 97.1%. Of the total participants, 60.7% (95%: CI (56-65%))
had good knowledge, 34.1% (95%: CI (30-39%)) had a positive attitude and 15.6% (95%: CI (12- 19%)) had good practices towards prevention and early detection of COVID-19. Less than one third of the participants practiced physical distancing (28%) and facemask
use (17.8%). |
|
|
Aweidah, H, Safadi, et al |
Clinical Ophthalmology |
Healthcare Response | Réponse des soins de santé |
To present our hybrid telehealth medical retina clinic service with intravitreal injections (IVI) treatment as a safe
alternative to in-person visits and examination during COVID-19 pandemic disease. Due to exposure to a COVID-19 positive retina fellow, our retina service, in quarantine, evaluated patients’ medical files and retinal scans using a telemedicine approach. A
different protocol for patients coming for IVI during the COVID-19 pandemic was established for IVI administration. During the 14-day quarantine period (between March 18th and March 31st 2020), the hybrid telehealth medical retina clinic performed 523 IVI
to 394 patients with a mean age ± SD 70.96 ± 14.4 years. IVI were administered for neovascular age-related macular degeneration in 50.5% of the cases (199 patients), diabetic macular edema in 21.3% (84 patients), retinal vein occlusion in 17.5% (69 patients),
and 10.7% for other retinal pathologies (42 patients). No ocular or systemic complications were observed. |
|
|
SARS-CoV-2 Infects Human Engineered Heart Tissues and
Models COVID-19 Myocarditis |
Bailey, AdamL, Dmytrenko, et al |
bioRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
Here, we develop a human engineered heart tissue model and demonstrate that SARS-CoV-2 selectively infects cardiomyocytes.
Viral infection is dependent on expression of angiotensin-I converting enzyme 2 (ACE2) and endosomal cysteine proteases, suggesting an endosomal mechanism of cell entry. After infection with SARS-CoV-2, engineered tissues display typical features of myocarditis,
including cardiomyocyte cell death, impaired cardiac contractility, and innate immune cell activation. Consistent with these findings, autopsy tissue obtained from individuals with COVID-19 myocarditis demonstrated cardiomyocyte infection, cell death, and
macrophage-predominate immune cell infiltrate. These findings establish human cardiomyocyte tropism for SARS-CoV-2 and provide an experimental platform for interrogating and mitigating cardiac complications of COVID-19. |
|
Balkrishna, A, Solleti, et al |
Molecules |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique Animal model | Modèle animal |
We report the use of a humanized zebrafish model, xeno-transplanted with human lung epithelial cells, A549, for studying
the protective effects of a tri-herbal medicine Coronil. At human relevant doses of 12 and 58 µg/kg, Coronil inhibited SARS-CoV-2 spike protein, induced humanized zebrafish mortality, and rescued from behavioral fever. Morphological and cellular abnormalities
along with granulocyte and macrophage accumulation in the swim bladder were restored to normal. Skin hemorrhage, renal cell degeneration, and necrosis were also significantly attenuated by Coronil treatment. Ultra-high-performance liquid chromatography (UHPLC)
analysis identified ursolic acid, betulinic acid, withanone, withaferine A, withanoside IV-V, cordifolioside A, magnoflorine, rosmarinic acid, and palmatine as phyto-metabolites present in Coronil. In A549 cells, Coronil attenuated the IL-1β induced IL-6 and
TNF-α cytokine secretions, and decreased TNF-α induced NF-κB/AP-1 transcriptional activity. Taken together, we show the disease modifying immunomodulatory properties of Coronil, at human equivalent doses, in rescuing the pathological features induced by the
SARS-CoV-2 spike protein, suggesting its potential use in SARS-CoV-2 infectivity. |
|
|
Barbieri, DM, Lou, et al |
Data in Brief |
Public Health response| Interventions de santé publique |
The dataset documents the mobility disruptions and the modal shifts that have occurred as a consequence of the restrictive
measures implemented in ten countries: Australia, Brazil, China, Ghana, India, Iran, Italy, Norway, South Africa and the United States. An online questionnaire was distributed during the period from the 11st to the 31st of May 2020, with a total of 9 394 respondents.
The first part of the survey has characterized the frequency of use of all transport modes before and during the enforcement of the restrictions, while the second part of the survey has dealt with perceived risks of contracting COVID-19 from different transport
modes and perceived effectiveness of travel mitigation measures. Overall, the dataset (stored in a repository publicly available) can be conveniently used to quantify and understand the modal shifts and people's cognitive behavior towards travel due to COVID-19. |
|
|
Adaptive Test Allocation for Outbreak Detection and Tracking in Social Contact Networks |
Batlle, Pau, Bruna, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
We present a general framework for adaptive allocation of viral tests in social contact networks. We pose and solve
several complementary problems. First, we consider the design of a social sensing system whose objective is the early detection of a novel epidemic outbreak. In particular, we propose an algorithm to select a subset of individuals to be tested in order to
detect the onset of an epidemic outbreak as fast as possible. We pose this problem as a hitting time probability maximization problem and use submodularity optimization techniques to derive explicit quality guarantees for the proposed solution. Second, once
an epidemic outbreak has been detected, we consider the problem of adaptively distributing viral tests over time in order to maximize the information gained about the current state of the epidemic. We formalize this problem in terms of information entropy
and mutual information and propose an adaptive allocation strategy with quality guarantees. For these problems, we derive analytical solutions for any stochastic compartmental epidemic model with Markovian dynamics, as well as efficient Monte-Carlo-based algorithms
for non-Markovian dynamics. Finally, we illustrate the performance of the proposed framework in numerical experiments involving a model of Covid-19 applied to a real human contact network. |
|
Bertone, F, Robiolio, et al |
Am J Case Rep |
Clinical data| Données cliniques |
This report is of a case of vocal cord ulceration following endotracheal intubation and mechanical ventilation in a
patient with severe COVID-19 pneumonia. A 57-year-old woman was admitted to our hospital (Ospedale Degli Infermi, Biella, Italy) presenting with symptoms of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, later confirmed by PCR. She
was extubated after 9 days in the intensive care unit. After extubation, the patient experienced an onset of dysphonia, and was evaluated by the otolaryngologist. The videolaryngoscopy revealed the presence of an ulceration at the level of the left vocal cord.
Steroids and proton pump inhibitors were administered as primary therapy for 1 week. Two weeks later, a significant improvement in the patient's voice quality was observed. |
|
|
Bhattacharya, R, Gupta, et al |
Virology |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study examined Nisin, a food-grade antimicrobial peptide produced by lactic acid bacteria for its probable interaction
with the human ACE2 (hACE2) receptor, the site where spike protein of SARS-CoV-2 binds. Among the eight nisin variants examined, nisin H, nisin Z, nisin U and nisin A showed a significant binding affinity towards hACE2, higher than that of the RBD (receptor
binding domain) of the SARS-CoV-2 spike protein. The molecular interaction of nisin with hACE2 was investigated by homology modeling and docking studies. Further, binding efficiency of the most potent nisin H was evaluated through the interaction of hACE2:nisin
H complex with RBD (receptor-binding domain) of SARS-CoV-2 and that of hACE2:RBD complex with nisin H. Nisin H acted as a potential competitor of RBD to access the hACE2 receptor. |
|
|
Bıkmazer, A, Kadak, et al |
Int J Soc Psychiatry |
Mental Health |
|
This large-scale multicenter online survey examined the COVID-19 related stress and psychological burden of the parents
with different occupational, locational, and mental health status related backgrounds. Multivariable logistic regression analysis showed that being a HCW parent (odds ratio 1.79, p < .001), a mother (odds ratio 1.67, p < .001), and a younger parent (odds ratio
0.98, p = .012); living with an adult with a chronic physical illness (odds ratio 1.38, p < .001), having an acquaintance diagnosed with COVID-19 (odds ratio 1.22, p = .043), positive psychiatric history (odds ratio 1.29, p < .001), and living with a child
with moderate or high emotional distress (odds ratio 1.29, p < .001; vs. odds ratio 2.61, p < .001) were independently associated with significant parental distress. |
|
|
Favorable outcome of COVID-19 infection in a patient with congenital myasthenic
syndrome |
Bonanno, Silvia, Maggi, et al |
Research Square prepub |
Clinical data| Données cliniques |
Patients affected by neuromuscular disorders (NMDs) are theoretically at higher risk for severe illness from SARS-CoV2
due to respiratory and swallowing muscle weakness 1. Here we describe the first case of congenital myasthenic syndrome (CMS) who was infected with COVID-19 and showed a positive outcome. |
|
Boufkhed, S, Namisango, et al |
Journal of pain and symptom management |
Healthcare Response | Réponse des soins de santé |
Objectives: To evaluate the preparedness and capacity of African palliative care services to respond to the COVID-19
pandemic. Methods: We developed, piloted, and conducted a cross-sectional online survey guided by the 2005 International Health Regulations. It was electronically mailed to the 166 African Palliative Care Association's members and partners. Results: About
83 participants from 21 countries completed the survey. Most services had at least one procedure for the case management of COVID-19 or another infectious disease (63%). Respondents reported concerns over accessing running water, soap, and disinfectant products
(43%, 42%, and 59%, respectively) and security concerns for themselves or their staff (52%). |
|
|
Public attitudes toward allocating scarce resources in the COVID-19 pandemic |
Buckwalter, W, Peterson, et al |
PLoS One |
Public Health response| Interventions de santé publique |
We conducted three preregistered experiments, involving a total of 1,868 U.S. residents, between April and May 2020,
when the COVID-19 death toll in the United States exceeded 100,000. All participants were adult residents of the United States. We found that participants agreed with allocation motivated by utilitarian principles and prioritizing the worst-off during initial
distribution of resources and disagreed with allocation motivated by egalitarian and social usefulness principles. At reallocation, participants agreed with giving priority to those patients who received the resources first. Lastly, support for utilitarian
allocation varied when saving the greatest number of lives resulted in disadvantage for at-risk or historically marginalized groups. Specifically, participants expressed higher levels of agreement with policies that shifted away from maximizing benefits to
one that assigned the same priority to members of different groups if this mitigated disadvantage for people of color. |
|
COVID-19 and breast cancer at a Regional Breast Centre: our flexible approach during
the pandemic |
Cadili, L, DeGirolamo, et al |
Breast Cancer Res Treat |
Healthcare Response | Réponse des soins de santé |
This study captured the effect of COVID-19 on the volume of surgery and adaptations to the surgical care of patients
at a breast centre in BC. In 2019, 99 patients underwent surgery for proven breast cancer and 30 patients for suspected breast cancer. In 2020, 162 patients underwent surgery for breast cancer and 34 for suspected breast cancer. Wait times from core biopsy
to surgery and surgery to oncology consultation were improved in 2020 with a reduction of core biopsy to surgery time from 58 to 28 days for patients seen during the pandemic. There was an increased use of regional anesthesia and same day discharge compared
to 2019 with increases in regional anesthesia (41%-89%) and same day discharge (64%-86%) after adaptations to the pandemic were implemented. |
|
Cai, J, Wang, et al |
Virol Sin |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This prospective study tried to understand the epidemiological and clinical features of the symptomatic and asymptomatic
pediatric cases of COVID-19. A total of 49 children (mean age 11.5 ± 5.12 years) confirmed with SARS-CoV-2 infection were enrolled in the study, including 11 (22.4%) domestic cases and 38 (77.6%) imported cases. Nine (81.8%) local cases and 12 (31.6%) imported
cases had a definitive epidemiological exposure. Twenty-eight (57.1%) were symptomatic and 21 (42.9%) were asymptomatic. Neither asymptomatic nor symptomatic cases progressed to severe diseases. The mean duration of viral shedding for SARS-CoV-2 in upper respiratory
tract was 14.1 ± 6.4 days in asymptomatic cases and 14.8 ± 8.4 days in symptomatic cases (P > 0.05). Children < 7 years shed viral RNA in stool for a longer duration than school-aged children (P < 0.05). Forty-three (87.8%) cases had seropositivity for antibodies
against SARS-CoV-2 within 1-3 weeks after confirmation with infection. |
|
|
Informative treatment
and media competencies of digital native media in the time of COVID-19 |
Calva-Cabrera, K, Rivera-Rogel, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Public Health response| Interventions de santé publique |
The objective of this study is to analyze the informative treatment that Loja’s native digital media (First Report
and Lo del Momento Loja) gave to news about Covid-19; likewise, to know the media competencies of the journalists who carry out the coverage. A citizens’ survey was applied to see how the subject was informed, and finally, editors from the two media were interviewed
to obtain first-hand the way of handling information and media competencies of their journalistic team. Results show that despite giving a neutral treatment to content broadcast on Covid-19, 25% of the news caused disinformation; Citizens affirm that the media
do not adequately fulfill their task of reporting and say they have lost credibility in the media. |
|
Caro-Patón, GL, de Azagra-Garde, et al |
J Intensive Care Med |
Clinical data| Données cliniques |
This study describes the characteristics of shock and myocardial injury in children with confirmed or suspeted COVID-19
during the SARS-CoV-2 pandemic in Spain, including clinical presentation, laboratory and imaging findings, treatment, disease course, and outcome. Twelve previously healthy patients with shock, age 5 to 14 years, were included. All required volume resuscitation
and 75% required vasoactive/inotropic support. Distributive shock was present on admission in 67% (n = 8), and 4 patients (33%) showed features of cardiogenic shock. Myocardial injury was diagnosed in 67% (n = 8) and ventricular dysfunction in 33% (n = 4).
The most common symptoms on presentation were fever (100%), anorexia (100%), diarrhea (75%), and vomiting (75%). Five patients showed signs of Kawasaki disease but none met the criteria for the classic form. Laboratory findings revealed lymphopenia (83%),
thrombocytopenia (83%), and increased inflammatory markers (100%). Respiratory status was not significantly impacted. Chest X-ray showed bilateral alveolar infiltrates in 7 (58%) and bilateral pneumonia in 3 (25%). COVID-19 was confirmed in 11 cases (92%).
All received empirical therapy against COVID-19, thromboprophylaxis and immunomodulation. Median stay in the PICU and inpatient ward was 4.5 and 10 days, respectively. No patients died. |
|
|
Carpio-Jiménez, L, Barrazueta, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Mental Health |
|
Through this qualitative research with an exploratory approach, positive or negative emotions are analyzed, specifically
the levels of humor or laughter that these graphic resources generate during the first months of the pandemic in Ecuador. The hypotheses are: 1. Memes make people improve their anxiety levels during isolation caused by the health emergency, and 2. There is
little acceptance of memes that belong to political figures. The results show that 89.5% of participants improved their anxiety levels after observing this sample of memes. |
|
|
Diabetes-related major and minor amputation risk increased during the COVID-19 pandemic |
Casciato, DJ, Yancovitz, et al |
J Am Podiatr Med Assoc |
Healthcare Response | Réponse des soins de santé |
We studied the effect of the pandemic on inpatients with diabetic foot problems in a level-one trauma center in Central
Ohio. METHODS: A retrospective chart review of patients necessitating a consultation by the foot and ankle surgery service were reviewed from the first 8 months of 2020. RESULTS: Of the patients undergoing any amputation, the odds for receiving a major amputation
was 3.1 times higher than before the pandemic. Additionally, the severity of infections increased during the pandemic and a larger proportion of the cases were classified as emergent in the pandemic group compared to the pre-pandemic group. |
|
Catania, C, Spitaleri, et al |
Frontiers in Oncology |
Mental Health |
|
This study tried to understand patients’ fears and expectations during the pandemic period by interviewing 156 patients
with lung cancer. The survey showed that during the pandemic period some patients experienced fear of COVID-19, in particular: women (55% vs. 33%), patients with comorbidities (24% vs. 9%), and patients who had already received prior insult (radiotherapy
or surgery) on the lung (30% vs. 11%). In addition, the patients who received oral treatment at home or for whom intravenous treatment was delayed, experienced a sense of relief (90% and 72% respectively). However, only 21% of the patients were more afraid
of COVID-19 than of their cancer, in particular patients with long-term (> 12 months) vs. short-term cancer diagnosis (28% vs. 12.5%, respectively). Furthermore, the quarantine period or even just the lockdown period alone, worsened the quality of life of
some patients (40%), especially those in oral treatment (47%). This data demonstrate how lung cancer patients are more afraid of their disease than of a world pandemic. |
|
|
Social distancing as a public good under the COVID-19 pandemic |
Cato, S, Iida, et al |
Public health |
Public Health response| Interventions de santé publique |
The purpose of this study is to show that social distancing is a public good under the COVID-19 pandemic. Social distancing
is a public good under the COVID-19 pandemic for which the free-rider problem is particularly severe. Altruism and social norms are crucial factors in overcoming this problem. Using an original survey, we show that people with higher altruistic concerns and
sensitivity to shaming are more likely to follow social distancing measures. |
|
Chacón-Torres, JC, Reinoso, et al |
Sci Rep |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Healthcare
Response | Réponse des soins de santé |
This study presents a simplified low cost method to produce 10 g of nanoparticles in 100 mL of solution that was scaled
to one litter by parallelizing the process 10 times in just two days and allowing for the possibility of making ~ 50,000 COVID-19 tests. This communication helps in reducing the cost of acquiring MNP for diverse biomolecular applications supporting developing
country budgets constraints and chemical availability specially during the COVID-19 International Health Emergency. |
|
|
Chakotiya, AS, Sharma, et al |
Defence Life Science Journal |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study phytochemicals from Zingiber officinale were evaluated to find their binding with these proteins by conducting
ligand-receptor binding docking study with AutoDockVina. The structures were observed by visualizing softwares Pymol to determine unique amino acids of receptor proteins. Physicochemical properties of phytochemicals and chemotherapeutic markers were assessed
with Molinspiration tool. Docking study revealed that Gingerenone (-5.87 kcal/mol) and Zingiberene (-5.77 kcal/mol) have shown effective binding affinity towards ACE2. Shoagol (-5.72 kcal/mol), Zingerone (-5.79 kcal/mol) and Zingiberene (-5.52 kcal/mol) have
shown higher binding with extracellular domain of serine protease TMPRSS2. Zingiberene scored significant binding energy of -6.23 kcal/mol with Spike protein of SARS-CoV-2. |
|
|
Chambless, Lloyd |
medRxiv |
Epidemiology| Épidémiologie |
We show here that counties with a higher percentage of Democratic vote in the 2016 presidential election have a lower
mean cumulative per capita rate of COVID-19 cases and of COVID-19 deaths, adjusted for county demographic and socio-economic characteristics, but only for counties in states that currently have a Democratic governor and both chambers of the legislature Democratic
or in states that have a mixed government, but not for states that currently have a Republican governor and both chambers in the legislature Republican. One possible contributor to this difference is that some state Republican governments have restricted local
action to fight the spread of COVID-19. |
|
|
Survey of COVID-19 preparedness among
lebanese ICU physicians |
Chami, HA, Abi Saleh, et al |
Journal Medical Libanais |
Healthcare Response | Réponse des soins de santé |
This study assessed intensive care units (ICU) resources, COVID-19 preparedness and the availability of personal protective
equipment (PPE) to ICU practitioners in Lebanon. Eighty-nine ICU physicians working at 51 hospitals in all Lebanese regions completed the survey. The recommended PPE for ICU physicians (N95 masks, face shields and impermeable body-gowns) and the needed fitting
and doning/doffing training were available to 34% of respondents. Dedicated wards and ICU for COVID-19 patients, negative pressure ICU rooms, video-laryngoscopes and COVID-19 testing were available on-site at 17% of respondents' hospitals. |
|
Forecasting imported COVID-19 cases in South Korea using mobile roaming data |
Choi, SB, Ahn, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
To assess the risks from imported COVID-19 cases in South Korea, we suggest using the daily risk score. Confirmed COVID-19
cases reported by John Hopkins University Center, roaming data collected from Korea Telecom, and the Oxford COVID-19 Government Response Tracker index were included in calculating the risk score. The risk score was highly correlated with imported COVID-19
cases after 12 days. To forecast daily imported COVID-19 cases after 12 days in South Korea, we developed prediction models using simple linear regression and autoregressive integrated moving average, including exogenous variables (ARIMAX). In the validation
set, the root mean squared error of the linear regression model using the risk score was 6.2, which was lower than that of the autoregressive integrated moving average (ARIMA; 22.3) without the risk score as a reference. Correlation coefficient of ARIMAX using
the risk score (0.925) was higher than that of ARIMA (0.899). A possible reason for this time lag of 12 days between imported cases and the risk score could be the delay that occurs before the effect of government policies such as closure of airports or lockdown
of cities. |
|
Choudhary, R, Mathur, et al |
American Journal of Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
In this study, we performed a retrospective analysis of all consecutive patients who were admitted for AHF (de novo
and ADHF; left ventricular ejection fraction <40%) in two Medical college hospitals providing healthcare services in Jodhpur, western India. Our analysis of patients admitted during the study (lockdown) period revealed 69% reduction in AHF hospitalizations
as compared to the control period (241 vs 782) and 60% reduction compared to same calendar period from the previous year (144 vs 602). |
|
|
Chow, WK, Chow, et al |
Indoor and Built Environment |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
A two-stage containment scheme is proposed with quarantining people into units within blocks. The units inside a block
is to be open after being closed for quarantine for an agreed period such as 14 days. The blocks would then be sealed for another period before opening. Argument of the proposal was supported by a simple mathematical approach with parameters deduced from observations
on a cruise ship to estimate the infection constant. The proposed containment scheme is believed to be effective in controlling the spreading of SARS-CoV-2 and identifying APs by a more targeted screening test for the suspected group with a more acceptable
environment at the second stage of containment. |
|
|
32976991; Temporal and age distributions of SARS-CoV-2 and other coronaviruses,
southeastern France |
Colson, P, Esteves-Vieira, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie |
We aimed to compare the age and weekly distributions of the five human coronaviruses, including SARS-CoV-2, that circulated
in southeastern France. For SARS-CoV-2, positive children <15 years of age represented 3.4% (228/6,735) of all positive cases, which is significantly less than for endemic coronaviruses (46.1%; 533/1,156; p < 0.001). Among 10,026 patients tested for SARS-CoV-2
and endemic coronaviruses in 2020, children <15 years represented a significantly lower proportion of all positive cases for SARS-CoV-2 than for endemic coronaviruses 2.2% (24/1,067) vs. 33.5% (149/445), respectively; p < 0.001]. Epidemic curves for endemic
coronaviruses and SARS-CoV-2 in 91,722 patients showed comparable bell-shaped distributions with a slight time lag. In contrast, the age distribution of endemic coronaviruses and 14 other respiratory viruses differed significantly compared to that of SARS-CoV-2,
which was the only virus to relatively spare children. |
|
Conde-Vázquez, E, Fontenla-Pedreira, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Public Health response| Interventions de santé publique |
Article in Spanish. This research work presents an analysis of the media coverage and the dissemination of fake news
and hoaxes through the social network Twitter and the work of verification and denial by different fact-checking platforms, in this case, Newtral and “Maldito Bulo”. The investigation will focus on hoaxes about the measures taken by the Government of Spain
during the “State of Alarm”, period caused by the crisis of the COVID-19 pandemic. The purpose of the investigation will be determined by the contribution of the media to the issemination of hoaxes, increasing sensationalism and ignoring the principle of public
service information by which the media should be governed. |
|
|
Cosma, S, Carosso, et al |
American Journal of Obstetrics and Gynecology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
With this study, we evaluated severe acute respiratory syndrome coronavirus 2 infection as a risk factor for early
pregnancy loss in the first trimester of pregnancy. Of 225 women, 23 (10.2%) had a positive test result for COVID-19. There was no difference in the cumulative incidence of COVID-19 between the cases (11/100, 11%) and the controls (12/125, 9.6%) (P=.73).
Logistic regression analysis confirmed that coronavirus disease 2019 was not an independent predictor of early pregnancy loss (odds ratio, 1.28; confidence interval, 0.53–3.08). COVID-19–related symptoms in the first trimester were fever, anosmia, ageusia,
cough, arthralgia, and diarrhea; no cases of pneumonia or hospital admission owing to coronavirus disease 2019–related symptoms were recorded. No difference in the incidence of symptoms was noted between the 2 groups. |
|
|
Daher, A, Balfanz, et al |
Respiratory medicine |
Long-Term Sequelae |
|
Hospitalized COVID-19 patients not requiring mechanical ventilation were included and followed 6 weeks after discharge.
Hospitalized patients with severe COVID-19, who did not require mechanical ventilation, are unlikely to develop pulmonary long-term impairments, thromboembolic complications or cardiac impairments after discharge but frequently suffer from symptoms of fatigue. |
|
|
Dai, M, Liu, et al |
International Journal of Medical Sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to perform a longitudinal analysis of serial CT findings over time in patients with COVID-19 pneumonia.
The extent of CT abnormalities in the severe and non-severe groups peaked in disease week 2. The temporal changes of CT manifestations followed a specific pattern, which might indicate disease progression and recovery. |
|
|
Dawood, AA, Altobje, et al |
Microbial pathogenesis |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Our study aimed to find out the mechanism action of tunicamycin on the viral glycoproteins. The growth of coronavirus
in the presence inhibitor tunicamycin resulted in the production of spikeless, non-infectious virions which were devoid of S protein. We concluded that tunicamycin inhibits E2, S, and M glycoproteins of coronaviruses. Tunicamycin is also diminished glycosylation
od PTMs such as HE, and 8 ab of SARS-CoV. Finally, we recommend using this drug to treat the SARS-CoV-2. |
|
|
COPD assessment test for the evaluation of COVID-19 symptoms |
Daynes, E, Gerlis, et al |
Thorax |
Healthcare Response | Réponse des soins de santé |
There is evidence to demonstrate the ongoing symptoms of COVID-19; however, there are currently no agreed outcomes
to assess these symptoms. This study examined the use of the chronic obstructive pulmonary disease (COPD) assessment test (CAT) for patients recovering from COVID-19. 131 patients who were admitted with COVID-19 were followed up over the phone to assess symptoms.
The median (IQR) CAT score was 10 (5-16). Cough, phlegm and chest tightness domains were within range for healthy people, but there was evidence of significant breathlessness, loss of energy, and activity and sleep disturbance. The CAT is a useful tool to
assess symptoms of COVID-19 recovery. |
|
de Girolamo, G, Bellelli, et al |
Frontiers in Psychiatry |
Epidemiology| Épidémiologie |
The aim of this manuscript is to assess the extent of mortality rates of older adults in LTCF during the pandemic across
different regions of Italy, compared to the previous years and to older general population not resident in LTCF. During the pandemic, about 8.5% (N = 6,797) of Italian older adults residents in LTCF died. Findings resulting from the O/E ratio suggest that
LTCF residents (in particular in the Lombardy Region) show higher mortality rates when compared to expected values of mortality rates among the older general population living in the community. Furthermore, we found that the risk of death among LTCF residents
increased about 4 times during the pandemic when compared to the previous years. |
|
|
de Terwangne, C, Laouni, et al |
Pathogens |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to assess the predictive accuracy of the WHO COVID-19 severity classification on COVID-19 hospitalized
patients. The secondary aim was to compare its predictive power with a new prediction model, named COVID-19 EPI-SCORE, based on a Bayesian network analysis. Our cohort’s median age was 73 (62–83) years, and the female proportion was 43%. All patients were
classified following WHO severity classification at admission. In total, 125 (42.4%) were classified as Moderate, 69 (23.4%) as Severe, and 101 (34.2%) as Critical. Death proportions through these three classes were 11.2%, 33.3%, and 67.3%, respectively, and
the proportions of critically ill patients (dead or needed Invasive Mechanical Ventilation) were 11.2%, 34.8%, and 83.2%, respectively. Our study shows that the WHO severity classification is reliable in predicting a severe outcome among COVID-19 patients.
The addition to this classification of a few clinical and laboratory variables as per our COVID-19 EPI-SCORE has demonstrated to significantly increase its accuracy. |
|
|
Intranasal fusion inhibitory lipopeptide prevents direct
contact SARS-CoV-2 transmission in ferrets |
de Vries, RoryD, Schmitz, et al |
bioRxiv |
Transmission Therapeutics| Thérapeutique Animal model | Modèle animal |
We have designed a dimeric lipopeptide fusion inhibitor that blocks this critical first step of infection for emerging
coronaviruses and document that it completely prevents SARS-CoV-2 infection in ferrets. Daily intranasal administration to ferrets completely prevented SARS-CoV-2 direct-contact transmission during 24-hour co-housing with infected animals, under stringent
conditions that resulted in infection of 100% of untreated animals. These lipopeptides are highly stable and non-toxic and thus readily translate into a safe and effective intranasal prophylactic approach to reduce transmission of SARS-CoV-2. |
|
Dhar, P, Roy, et al |
Defence Life Science Journal |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We aimed towards identifying novel phytoligands from widely available botanical resources which could serve as potential
inhibitors against SARS-CoV-2. 55 phytoligands and 8 synthetic repurposing drugs were screened and tested against SARS-CoV-2 spike glycoprotein, main protease, papain-like protease, and RNA-dependent RNA polymerase using molecular docking and protein-ligand
interaction. All phytoligands and repurposing drugs showed binding affinity based inhibitory potential against the viral proteins. The highest binding affinities of phytoligands towards antiviral targets were exhibited by colchicine and oleic acid, and that
of repurposing drugs was shown by saquinavir and nelfinavir. Capsaicin, oleic acid, azithromycin, nelfinavir, remdesivir, and saquinavir were acted as plausible broad-spectrum inhibitors. Hydrogen bonds and hydrophobic interactions of amino acids were varied
significantly within the conserved domain along with glutamic acid richness. |
|
|
Di Santo, SG, Franchini, et al |
Frontiers in Psychiatry |
Mental Health |
|
The study aimed to explore the effects of COVID-19 and quarantine measures on lifestyles and mental health of elderly
at increased risk of dementia. The sample included 55.6% patients with MCI and 56 people with SCD. Over 1/3 of the sample reduced their physical activity and nearly 70% reported an increase in idle time. Adherence to the Mediterranean diet decreased in almost
1/3 of respondents and over 35% reported weight gain. Social activities were abolished and 1/6 of participants also decreased productive and mental-stimulating activities. 19.8% were depressed, 9.5% anxious, and 9.5% apathetic. A significant association existed
between depression and living alone or having a poor relation with cohabitants and between anxiety and SCD, cold or flu symptoms, and reduction in productive leisure activities. |
|
|
Dinmohamed, AG, Cellamare, et al |
J Hematol Oncol |
Healthcare Response | Réponse des soins de santé |
Utilising data from the Netherlands Cancer Registry on provisional cancer diagnoses between 6 January 2020 and 4 October
2020, we assessed the impact of the temporary halt of national population screening programmes on the diagnosis of breast and colorectal cancer in the Netherlands. Fewer diagnoses of breast and colorectal cancer were objectified amid the early stages of the
initial COVID-19 outbreak in the Netherlands. This effect was most pronounced among the age groups eligible for cancer screening programmes, especially in breast cancer (age group 50-74 years). Encouragingly enough, the observed number of diagnoses ultimately
reached and virtually remained at the level of the expected values. This finding, which emerged earlier in age groups not invited for cancer screening programmes, comes on account of the decreased demand for critical COVID-19 care since early April 2020, which,
in turn, paved the way forward to resume screening programmes and a broad range of non-critical health care services, albeit with limited operating and workforce capacity. |
|
|
Covid-19 pandemic and anxiety related factors in patients treated in the emergency
department |
Durak, VA, Gunay, et al |
Signa Vitae |
Mental Health |
|
In this study, we sought to determine those factors that contributed to the anxiety level during the COVID-19 pandemic
using the ‘State’ subscale of State-Trait Anxiety Inventory (STAI-S). Methods: A survey was performed in the emergency department by using an online questionnaire which consisted of demographic variables, questions about the opinions and behaviors of patients
during the pandemic, diagnostic test results for COVID-19, and treatment methods. Results: There was a statistically significant difference between employment status (p ˂ 0.001), monthly income (p ˂ 0.001), the food consumption changes during the pandemic
period (p = 0.001) and the estimated end-date for the COVID-19 pandemic (p < 0.001) and total STAI-S points. |
|
Every-Palmer, S, Jenkins, et al |
PLoS One |
Mental Health |
|
We conducted an online panel survey of a demographically representative sample of 2010 adult New Zealanders in April
2020. The survey contained three standardised measures-the Kessler Psychological Distress Scale (K10), the GAD-7, and the Well-Being Index (WHO-5)-as well as questions designed specifically to measure family violence, suicidal ideation, and alcohol consumption.
It also included items assessing positive aspects of the lockdown. Thirty percent of respondents reported moderate to severe psychological distress (K10), 16% moderate to high levels of anxiety, and 39% low wellbeing; well above baseline measures. Suicidal
ideation was reported by 6%, with 2% reporting making plans for suicide and 2% reporting suicide attempts. Just under 10% of participants had directly experienced some form of family harm over the lockdown period. |
|
|
COVID-19 Confirmed Case Correlation Analysis Based on Spearman and Kendall
Correlation |
Fahrudin, T, Wijaya, et al |
|
Epidemiology| Épidémiologie |
This paper investigates the confirmed case analysis of a COVID-19 in all countries based on Spearman and Kendall correlation
and grouping those countries which have the same level correlation. There are 134 countries for the shortest period and 16 for the longest period have been evaluated. In the shortest period, 39 and 27 countries have high correlation value based on Spearman
and Kendall, respectively. In the longest period, 11 and 6 countries have high correlation value based on Spearman and Kendall, respectively. Those groups indicate that the strength of association of confirmed case between them are similar. The darker color
shows there is a high correlation value among those countries. So, by using those groups, the decision-maker can analyze the characteristic of those countries and make the decision better. |
|
Faridi, KF, Hennessey, et al |
Journal of the American Society of Echocardiography |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We collected data on clinical variables and mortality for all patients hospitalized with COVID-19 who underwent an
inpatient TTE between March 19, 2020, and April 30, 2020. Inpatient all-cause death and adjudicated cardiovascular death were assessed through June 1, 2020. This study suggests that LVEF is strongly associated with inpatient mortality in patients hospitalized
with COVID-19, even though deaths were primarily from noncardiovascular causes. |
|
|
Gaebler, Christian, Wang, et al |
bioRxiv |
Immunology | Immunologie |
Here we report on the humoral memory response in a cohort of 87 individuals assessed at 1.3 and 6.2 months after infection.
We find that IgM, and IgG anti-SARS-CoV-2 spike protein receptor binding domain (RBD) antibody titers decrease significantly with IgA being less affected. Concurrently, neutralizing activity in plasma decreases by five-fold in pseudotype virus assays. In contrast,
the number of RBD-specific memory B cells is unchanged. Memory B cells display clonal turnover after 6.2 months, and the antibodies they express have greater somatic hypermutation, increased potency and resistance to RBD mutations, indicative of continued
evolution of the humoral response. Analysis of intestinal biopsies obtained from asymptomatic individuals 3 months after COVID-19 onset, using immunofluorescence, electron tomography or polymerase chain reaction, revealed persistence of SARS-CoV-2 in the small
bowel of 7 out of 14 volunteers. |
|
|
Gaman, SA, Belkind, et al |
Russian Electronic Journal of Radiology |
Clinical data| Données cliniques |
Purpose. To demonstrate the value of chest computed tomography (CT) in patient with severe COVID-19 viral pneumonia
in choosing the optimal treatment strategy. Materials and methods. Chest CT dynamic studies of a patient with severe bilateral polysegmental viral COVID-19 pneumonia were performed. Results. The presented clinical case demonstrates the influence of the lung
CT results in choosing the optimal therapy, including the cytokine storm prevention using the interleukin-6 (IL6) receptor inhibitors. The dynamic observation of the lungs in monitoring of the intensive therapy results was performed. The changes of CT patterns
depending on the disease stage and results of treatment was studied. |
|
|
García-Salido, A, García-Teresa, et al |
Medicina Intensiva |
Clinical data| Données cliniques Immunology | Immunologie |
In this paper, we study three molecules which are part of the innate cellular response to infection: CD64, CD18 and
CD11a. We study in this report three children with severe SARS-CoV-2 infection. As results, we provide the description of CD64, CD18, and CD11a expression on neutrophils, monocytes and lymphocytes in children with severe SARS-CoV-2 disease. This expression
appears to be higher compared to other infections and may point to an exacerbated cellular innate response in these children. |
|
|
Gautier, SV, Shevchenko, et al |
Vestnik Transplantologii i Iskusstvennykh Organov |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The prevalence, risk factors, clinical manifestations and outcomes of the novel coronavirus disease 2019 (COVID-19)
in solid organ transplant recipients receiving immunosuppressive therapy were investigated. The study enrolled 251 COVID-19 patients (220 kidney recipients, 7 liver recipients, 1 liver-kidney recipient, and 23 heart recipients). The subjects came from 20 regions
in Russia. It was established that solid organ transplant recipients with COVID-19 have a higher risk of developing adverse events. Predictors of adverse events include associated cardiovascular diseases, pulmonary diseases, diabetes, and kidney failure. Symptoms
of the disease include dyspnea, rash and catarrhal signs, as well as initial low blood oxygen saturation (SpO2 10 × 109/L), elevated creatinine levels (>130 μmol/L) and a marked decrease in glomerular filtration rate, requiring hemodialysis. |
|
|
Occurrence of the Slippery Sequence UUUAAAC in the Genome that 1 Generates the ORF1ab of
SARS-CoV-2 |
Geurdes, Han |
SSRN- Lancet prepublication |
Coronavirology| Coronavirologie |
In the present report we look into the slippery sequence TTTAAAC (in cDNA format) of the ORF1ab protein of SARS-CoV-2.
We found a number of TTTAAAC sequences and only one is actively producing a shift -1. |
|
Retrospective survey from Vascular Access Team Lombardy
Net in COVID-19 era |
Gidaro, Antonio, Vailati, et al |
medRxiv |
Clinical data| Données cliniques |
Objective: Identify catheter related thrombosis (CRT), catheter-related bloodstream infection (CRBSI), and accidental
remove of VADs in both COVID-19 positive and COVID-19 free patients. Methods: This multicenter, retrospective cohort study was conducted using data from 7 hospitals in Lombardy during the pandemic period from February 21st to May 31st 2020. Results: In the
observation period 2206 VADs were evaluated, of which 1107 (50.2%) were inserted in COVID-19 patients. We recorded 42 (1.9%) CRT; 32 (79.2%) were observed in COVID-19 patients. Accidental removals were the more represented complication with 123 registered
cases, 85 of them (69.1%) were in COVID-19. COVID-19 significantly predicted occurrence of CRT, CRSB, and Accidental Removal in our propensity score weighted models. |
|
González Pessolani, T, Muñóz Fernández de Legaria, et al |
Revista Espanola de Patologia |
Clinical data| Données cliniques |
Different organ samples from four patients with PCR-confirmed COVID-19 at the Infanta Sofía Hospital (Madrid) were
studied during the months of April and May, 2020 by six pathologists using routine stains, histochemistry and immunohistochemistry. Results were compared with other reported cases. All patients had a clinical diagnosis of pneumonia and biopsies revealed lung
damage in the majority. Heart, liver, spleen and kidney were also studied and abnormalities were found in all cases and are extensively described. |
|
|
Gupta, Savyasachi, Kapil, et al |
arXiv |
Public health interventions*| Interventions de sant&eacute; publique |
This work proposes a novel framework named SD-Measure for detecting social distancing from video footages. The proposed
framework leverages the Mask R-CNN deep neural network to detect people in a video frame. To consistently identify whether social distancing is practiced during the interaction between people, a centroid tracking algorithm is utilised to track the subjects
over the course of the footage. With the aid of authentic algorithms for approximating the distance of people from the camera and between themselves, we determine whether the social distancing guidelines are being adhered to. |
|
|
Hameed, M, Jamal, et al |
Respiratory Medicine Case Reports |
Clinical data| Données cliniques |
We present a series of 3 cases of primary spontaneous pneumothorax with Covid-19 pneumonia. All cases in our series
did not require positive pressure ventilation and none had any pre-existing lung disease. All were never smokers and had favourable outcomes despite having severe Covid-19 with a pneumothorax during the course of the disease. |
|
|
Psychological symptoms of cancer survivors during the COVID-19 outbreak: a longitudinal study |
Han, J, Zhou, et al |
Psychooncology |
Mental Health |
|
The psychological status of cancer survivors is affected by their social environment. In this study, we investigated
the psychological status and psychological symptoms of Chinese cancer survivors.METHODS: A longitudinal study design was adopted, and an online sample of cancer survivors was successfully recruited via the internet communities of cancer support groups. From
February 14 to May 25, 111 cancer survivor families completed the symptom checklist 90 (SCL-90) online three times. The SCL-90 scores of cancer survivors were significantly higher than those of family members and Chinese norms at T1, T2, and T3. Nine psychological
symptoms of the SCL-90 in cancer survivors significantly declined from T1 to T2 and T3. |
|
Boosting test-efficiency by pooled testing for SARS-CoV-2-Formula for optimal
pool size |
Hanel, R, Thurner, et al |
PLoS One |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here we present a formula to estimate the optimal group-size for pooling, the efficiency gain (tested persons per test),
and the expected upper bound of missed infections in pooled testing, all as a function of the population-wide infection levels and the false negative/positive rates of the currently used PCR tests. Assuming an infection level of 0.1% and a false negative rate
of 2%, the optimal pool-size is about 34, and an efficiency gain of about 15 tested persons per test is possible. For an infection level of 1% the optimal pool-size is 11, the efficiency gain is 5.1 tested persons per test. For an infection level of 10% the
optimal pool-size reduces to about 4, the efficiency gain is about 1.7 tested persons per test. |
|
Haniff, HS, Tong, et al |
ACS Central Science |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Herein, we designed multiple bioactive small molecules that target a functional structure within the SARS-CoV-2's RNA
genome, the causative agent of COVID-19. An analysis to characterize the structure of the RNA genome provided a revised model of the SARS-CoV-2 frameshifting element, in particular its attenuator hairpin. By studying an RNA-focused small molecule collection,
we identified a drug-like small molecule (C5) that avidly binds to the revised attenuator hairpin structure with a Kd of 11 nM. |
|
|
Nutritional status assessment in patients with Covid-19 after discharge from
the intensive care unit |
Haraj, NE, El Aziz, et al |
Clinical Nutrition ESPEN |
Clinical data| Données cliniques |
The aim of our study is to assess the nutritional status of patients with COVID-19 after a stay in intensive care,
to describe the prevalence of undernutrition, to determine the factors influencing undernutrition and to describe the nutritional management. Despite a personalized diet, 14.6% of patients presented undernutrition. |
|
Haravuori, H, Junttila, et al |
International Journal of Environmental Research and Public Health |
Mental Health |
|
Authors discuss the psychological well-being of health care workers at Hospital District of Helsinki and Uusimaa (HUS)
Helsinki University Hospital. This work highlights the need to ensure appropriate psychosocial support services to all traumatized personnel; especially, nursing staff may require attention. |
|
|
Harsha, Prahladh, Juneja, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this report, we use the IISc-TIFR agent based simulator to develop long term projections for Mumbai under realistic
scenarios related to Mumbai's opening of the workplaces, or equivalently, the economy, and the associated public transportation through local trains and buses. These projections were developed taking into account a possible second wave if the economy and the
local trains are fully opened either on November 1, 2020 or on January 1, 2021. The impact on infection spread in Mumbai if the schools and colleges open on January first week 2021 is also considered. We also try to account for the increased intermingling
amongst the population during the Ganeshotsav festival as well as around the Navratri/Dussehra and Diwali festival. Our conclusion, based on our simulations, is that the impact of fully opening up the economy on November 1 is manageable provided reasonable
medical infrastructure is in place. Further, schools and colleges opening in January do not lead to excessive increase in infections. The report also explores the relative effectiveness of contact tracing vs containment zones, and also includes very rudimentary
results of the effect of vaccinating the elderly population in February 2021. |
|
|
Olfactory bulb magnetic resonance imaging in SARS-CoV-2-induced anosmia in pediatric
cases |
Hatipoglu, N, Mine Yazici, et al |
International journal of pediatric otorhinolaryngology |
Clinical data| Données cliniques |
In this paper, we report three cases of pediatric patients with COVID-19 infection who presented with different symptoms
and also anosmia and/or ageusia. The common feature of these 3 patients is that the smell and / or taste disorder developed without nasal symptoms such as nasal congestion, nasal obstruction or rhinorrhea. Although 40% of anosmies contains viral etiologies,
COVID- 19 differs from other viral anosmies by the lack of nasal congestion and runny nose. Coronaviruses could invade the brain via the cribriform plate close to the olfactory bulb and the olfactory epithelium. We may expect some structural changes in the
olfactory bulb so we evaluated our patient with cranial imaging. © 2020 Elsevier B.V. |
|
Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite
biomarker |
Heller, RA, Sun, et al |
Redox Biology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, authors tested the hypothesis that COVID-19 patients are characterised by Zn deficiency and that Zn
status provides prognostic information. They conclude that Zn and SELENOP status within the reference ranges indicate high survival odds in COVID-19, and assume that correcting a diagnostically proven deficit in Se and/or Zn by a personalised supplementation
may support convalescence. |
|
Prediction and Potential Spatially Explicit Spread of COVID-19 in Mexico's Megacity
North Periphery |
Hernández-Flores, ML, Escobar-Sánchez, et al |
Healthcare (Basel) |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
A Gumpertz model was adapted with official data from the state of Hidalgo, Mexico, in order to estimate the people
infected during this COVID-19 pandemic. Authors found that most of the infected people were located in the southern border, a trend related to the economic strip in the southern part of Hidalgo State, associated with its vicinity to the Megacity of Mexico. |
|
Hirouchi, T, Ota, et al |
Journal of Infection and Chemotherapy |
Clinical data| Données cliniques |
A 49-year-old Japanese male was managed by mechanical ventilation due to coronavirus disease 2019 (COVID-19) pneumonia.
Favipiravir as an antiviral therapy, and anti-inflammatory treatment were administered. SARS-CoV-2 RNA was detected in serum by the loop-mediated isothermal amplification (LAMP) method on Day 9; favipiravir treatment was continued. On Day 13, negative serum
RNA was confirmed, followed by mechanical ventilation was removed. On Day 23, LAMP negative was confirmed in nasopharynx, after that the patient discharged on Day 27. We could treat successfully for severe COVID-19 pneumonia based on the LAMP method. We consider
this method will be useful in COVID-19 treatment. © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases |
|
|
Hoque, ME |
International Journal of Modern Physics C |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The Susceptible, Infected and Recover (SIR) model is a very simple model to estimate the dynamics of an epidemic. In
the current pandemic due to Covid-19, the SIR model has been used to estimate the dynamics of infection for Bangladesh, India, Pakistan and compared with that of China. Numerical solutions are used to obtain the value of parameters for the SIR model. It is
predicted that the active case in Pakistan due to the SARS-CoV-2 will be comparable with that in China whereas it will be low for Bangladesh and India. The basic reproduction number, with fluctuations, for South Asian countries are predicted to be less than
that of China. The susceptible population is also estimated to be under a million for Bangladesh and India but it becomes very large for Pakistan. © 2020 World Scientific Publishing Company. |
|
|
Hou, F, Bi, et al |
BMC Public Health |
Mental Health |
|
This study investigated gender differences of depression and anxiety and explored associated factors during the COVID-19
epidemic among Chinese social media users. The findings show the increased prevalence of depression and anxiety in Chinese population during the COVID-19 epidemic, and females are experiencing more severe anxiety symptoms than males. |
|
|
Huang, H, Zhang, et al |
|
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Authors demonstrate the potential of a fluorescence detection technique along with machine-learning based classification
for COVID-19 virus detection. They found that dimension-reduced data in 3 principal components (PCs) space performs better than that in 2 PCs space in machine learning algorithms. |
|
|
An international survey on the impact of COVID-19
in individuals with Down syndrome |
Huels, Anke, Costa, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The T21RS COVID-19 Initiative launched an international survey for clinicians or caregivers/family members on patients
with COVID-19 and DS (N=1046). De-identified survey data collected between April and October 2020 were analysed and compared with the UK ISARIC4C survey of hospitalized COVID-19 patients with and without down syndrome (DS). Leading signs/symptoms of COVID-19
and risk factors for severe disease course are similar to the general population. However, individuals with DS present significantly higher rates of mortality, especially from age 40. |
|
Ibrahim, H, Sorrell, et al |
Acta Informatica Medica |
Healthcare Response | Réponse des soins de santé |
This manuscript describes the system development, collaborative efforts and the challenges encountered in developing
an in-house clinical intelligence dashboard. The dashboard has enabled physicians to efficiently assess patient volumes and case severity to prioritize clinical care and appropriately allocate scarce resources. |
|
|
MuLBSTA score is a useful tool for predicting COVID-19 disease behavior |
Iijima, Y, Okamoto, et al |
Journal of Infection and Chemotherapy |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
MuLBSTA score is a scoring system that predicts the mortality of viral pneumonia induced by a variety of viruses, including
coronavirus, but the scoring system has not been verified in novel coronavirus pneumonia. The aim of this study was to validate this scoring system for estimating the risk of disease worsening in patients with COVID-19. This scoring system may be used as
one of the criteria to identify high-risk patients worsening to life-threatening status. |
|
Factors influencing the COVID-19 daily deaths peak
across European countries |
Jablonska, Katarzyna, Aballea, et al |
medRxiv |
Epidemiology| Épidémiologie |
The purpose of this study was to determine predictors of the height of COVID-19 daily deaths peak and time to the peak,
in order to explain their variability across European countries. The analysis demonstrated that countries with higher proportions of the population living in urban areas, with lower reduction in mobility at the beginning of the pandemic, and countries which
closed borders having more infected people experienced higher peak of COVID-19 deaths. |
|
Olfactory Bulb MRI and Paranasal Sinus CT Findings in Persistent COVID-19 Anosmia |
Kandemirli, SG, Altundag, et al |
Academic Radiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
There is limited literature consisting of case reports or series on olfactory bulb imaging in COVID-19 olfactory dysfunction.
An imaging study with objective clinical correlation is needed in COVID-19 anosmia in order to better understand underlying pathogenesis. We evaluated 23 patients with persistent COVID-19 olfactory dysfunction. Our findings indicate olfactory cleft and olfactory
bulb abnormalities are seen in COVID-19 anosmia. There was a relatively high percentage of olfactory bulb degeneration. |
|
Liver injury with COVID-19 based on gastrointestinal symptoms and pneumonia severity |
Kaneko, S, Kurosaki, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to identify factors associated with liver injury and to develop a new classification of predictive
severity in patients with COVID-19. A logistic regression analysis revealed that C-reactive protein (CRP) at baseline, oxygenation, intubation, and GS were significant factors of liver injury. Based on these results, patients were classified into three groups:
group 1, no oxygenation pneumonia; group 2, pneumonia with oxygenation or GS; and group 3, intubation. We classified 25 (41.7%), 26 (43.3%), and 9 (15.0%) patients into mild, moderate, and severe groups, respectively. The peak of AST and ALT levels was significantly
stratified with this criteria (mild [median AST, 28 IU/L; median ALT, 33 IU/L], moderate [median AST, 48 IU/L; median ALT, 47.5 IU/L], and severe [median AST, 109 IU/L; median ALT, 106 IU/L]; P<0.001 and P = 0.0114, respectively). |
|
Karahasan Yagci, A, Sarinoglu, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to evaluate the severity of chest CT in reverse transcriptase polymerase chain reaction (RT-PCR)-positive
patients and factors associated with it. Findings show that viral load was not a critical factor for hospitalization and mortality. Outpatients had considerable amounts of virus in their nasopharynx, which made them contagious to their contacts. Viral load
is important in detecting early stages of COVID-19, to minimize potential spread, whereas chest CT can help identify cases requiring extensive medical care. |
|
|
Kasting, ML, Head, et al |
PLoS One |
Public Health response| Interventions de santé publique |
In May 2020, we conducted a cross-sectional survey among U.S. adults (N = 3,474). The primary outcome was a six-item
measure assessing perceived effectiveness of recommended behaviors to prevent SARS-CoV-2 infection from 1 (not at all effective) to 5 (extremely effective). This research indicates people generally believe NPI are effective, but there was variability based
on health beliefs and there are mixed rates of engagement in these behaviors. |
|
|
Kazancioglu, S, Bastug, et al |
Epidemiol Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, the laboratory data of 120 COVID-19 patients, 100 influenza patients, and 61 healthy controls were evaluated.
Lower lymphocytes, eosinophils, basophils, platelets, and higher delta neutrophil index (DNI), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) were found in COVID-19 and influenza groups compared to healthy controls. The eosinophils,
lymphocytes, and PLR made the highest contribution to differentiate COVID-19 patients from healthy controls (Area under the curves (AUC)s: 0.819, 0.817, 0.716, respectively. The p-value is <0.0001 for all). In conclusion, NLR and PLR can be used as biomarkers
to distinguish COVID-19 patients from healthy people and to predict the severity of COVID-19. |
|
|
Khanal, Pratik, Devkota, et al |
bioRxiv |
Mental Health |
|
This study aimed to identify factors associated with COVID-19 fear among health workers in Nepal during the early phase
of pandemic. COVID-19 fear score was moderately correlated with anxiety and depression, and weakly correlated with insomnia (p<0.001). Nurses (AOR=2.29; 95% CI: 1.23-4.26), health workers experiencing stigma (AOR=1.83; 95% CI: 1.12-2.73), those working
in affected district(AOR=1.76; 95% CI: 1.12-2.77) and presence of family member with chronic diseases (AOR=1.50; 95% CI: 1.01-2.25) was associated with higher odds of developing COVID-19 fear as compared to other health workers, health workers not experiencing
stigma, working in non affected district and not having family member with chronic diseases respectively . |
|
|
Khoshchehreh, M, Wald-Dickler, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In the course of universal admission screening with the Cepheid Xpert Xpress SARS-CoV-2 assay at our institution, we
observed that 3.9 % (44/1123) of SARS-CoV-2 positive results were negative for the envelope (E) gene target but positive for the nucleocapsid (N2) target. The overall SARS-CoV-2 positivity rate during the three-month study period was 15.4 % (1123/7285), spanning
April-June 2020. Most patients with E-target-negative, N2-target-positive results were asymptomatic, but 25 % of those who underwent chest radiographic imaging had findings concerning for viral pneumonia suggesting subclinical infection. E-target-negative,
N2-target-positive results were present in 8 symptomatic patients with a new diagnosis of COVID-19. Our findings suggest that the maximal PCR sensitivity is essential in hospital settings and that E-negative, N2-positive results can be significant. |
|
|
Khraise, WN, Khraise, et al |
International Journal of General Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to investigate the epidemiologic features, clinical presentations, laboratory examination, and outcomes
of COVID-19 patients in Jordan. Approximately 42% of the quarantined individuals were asymptomatic. The majority of symptomatic patients had mild to moderate symptoms of the disease. Only ten patients (9.3%) had severe symptoms, with one of them progressed
to a critical stage and died 15 days after admission. Erythrocyte sedimentation rate (ESR), lactate dehydrogenase (LDH), and D-dimer levels were significantly elevated in many patients. More than two- thirds (69.8%) of the symptomatic patients were females.
Elevated ESR and LDH levels, along with longer periods of infection, were significantly associated with symptomatic patients. |
|
|
Bayesian model infers drug repurposing candidates for treatment of COVID-19 |
Kiebish, MichaelA, Shah, et al |
Research Square prepub |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Background The emergence of COVID-19 progressed into a global pandemic that has functionally put the world at a standstill
and catapulted major healthcare systems into an overburdened state. The dire need for therapeutic strategies to mitigate and successfully treat COVID-19 is now a public health crisis with national security implications for many countries. Methods The current
study employed Bayesian networks to a longitudinal proteomic dataset generated from Caco-2 cells transfected with SARS-CoV-2 (isolated from patients returning from Wuhan to Frankfurt) 1]. Two different approaches were employed to assess the Bayesian models,
a titer-center topology analysis and a drug signature enrichment analysis. Results Topology analysis identified a set of proteins directly linked to the SAR-CoV2 titer, including ACE2, a SARS-CoV-2 binding receptor, MAOB and CHECK1. Aligning with the topology
analysis, MAOB and CHECK1 were also identified within the enriched drug-signatures. Conclusions Taken together, the data output from this network has identified nodal host proteins that may be connected to 18 chemical compounds, some already marketed, which
provides an immediate opportunity to rapidly triage these assets for safety and efficacy against COVID-19. |
|
Kikuchi, H, Machida, et al |
J Epidemiol |
Mental Health |
|
This longitudinal study aimed to examine the changes in psychological distress of the general public from the early
to community-transmission phases of the COVID-19 pandemic and to investigate the factors related to these changes. An internet-based survey of 2,400 Japanese people was conducted in two phases: early phase (baseline survey: February 25–27, 2020) and community-transmission
phase (follow-up survey: April 1–6, 2020). In the two surveys, individuals with Severe psychological distress (SPD) were 9.3% and 11.3%, respectively, demonstrating a significant increase between the two phases (P = 0.005). Significantly higher likelihood
to develop SPD were observed among those in lower (ie, 18,600–37,200 United States dollars [USD], odds ratio [OR] 1.95; 95% confidence interval [CI], 1.10–3.46) and the lowest income category (ie, <18,600 USD, OR 2.12; 95% CI, 1.16–3.86). Furthermore, those
with respiratory diseases were more likely to develop SPD (OR 2.56; 95% CI, 1.51–4.34). |
|
|
Spread of variants with gene n hot spot mutations in russian SARS-COV-2 isolates |
Kiryanov, SA, Levina, et al |
Bulletin of Russian State Medical University |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
The study was aimed to perform the mutational and phylogenetic analysis of the Russian SARS-CoV-2 genomes at different
time periods and in various regions, as well as to characterize the mutational profiles of isolates using the bioinformatics approaches. The mutation accumulation was compared in 86 SARS-CoV-2 whole-genome sequences from Russia and 220 from Europe and North
America in order to reveal the characteristic gene variations, the possible positive selection patterns. Along with the known mutation variants in the structural proteins genes, typical for isolates of European origin, several additional mutations including
the synonymous mutation in gene M (C26750Т) characteristic for Russian isolates were revealed. Double mutation R203K and G204R in the nucleocapside gene which previously emerged in Europe began spreading and rapidly (within a month) became the dominant form
in Russia. The results obtained indicate that the viral genome of most Russian isolates evolves with accumulation of new mutations associated with increased viral transmission. |
|
Knowles, KA, Olatunji, et al |
Journal of anxiety disorders |
Mental Health |
|
-19. Accordingly, the present study prospectively examines contamination fear and obsessive-compulsive washing symptoms
as predictors of anxiety and safety behaviors in response to COVID-19 in a student sample (N = 108). To examine specificity, anxiety and safety behaviors in response to seasonal influenza are also examined. In the early stages of the pandemic (March 2020),
coronavirus-related anxiety was higher than flu-related anxiety (d = 1.38). Obsessive-compulsive washing symptoms also increased from before the pandemic (d = 0.4). Although baseline contamination fear and obsessive-compulsive washing symptoms did not significantly
predict coronavirus-related anxiety, contamination fear did significantly predict safety behavior usage in response to both COVID-19 and influenza. |
|
|
Kouriba, B, Dürr, et al |
Viruses |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Screening 217 Malian patient samples for the presence of SARS-CoV-2 resulted in 38 positive isolates, from which 21
whole genome sequences were generated. Our analysis shows that both the early A (19B) and the later observed B (20A/C) clade are present in Mali, indicating multiple and independent introductions of SARS-CoV-2 to the Sahel region. |
|
|
Predictive monitoring of secondary epidemic waves of COVID-19 in Iran, Russia and
other countries |
Kovriguine, DA, Nikitenkova, et al |
Bulletin of Russian State Medical University |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The purpose of this work was to call into use a simple dynamical system represented by the discrete logistic equation
with unknown parameters to predict secondary waves using the official statistical data. The mathematical modelling reveals the secondary epidemic waves in Sweden, the United States, Ukraine, Serbia, Romania, Czech Republic, Portugal, Luxembourg, Poland, and
Ecuador. Also, the second waves appear in Russia and other countries. Despite many individual differences in the epidemic spread in different countries, we have traced regularity in the rise of secondary waves. The beginning of each new wave, if focusing on
the number of total cases, practically coincides with the time of the maximum growth rate of the previous early epidemic. Thus, the passing through the threshold of the current wave should be the most responsible for strict observance of the rules of self-isolation
and other sanitary standards. |
|
COVID-19 in Hospitalized Ethiopian Children: Characteristics
and Outcome Profile |
Leulseged, TigistW, Hassen, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aims to assess the characteristics and outcome profile of 115 RT-PCR confirmed children with COVID-19, and
to determine the presence of significant difference in disease severity and survival distribution between groups among children admitted to Millennium COVID-19 Care Center in Ethiopia. The average duration of time to clinical improvement was 14 days and 74.4%
achieved clinical improvement. There was no death during the observation period. The pediatric patients seemed to have a milder disease presentation and a favorable outcome compared to other countries report and also the adult pattern observed in our country.
Having particular symptom groups is associated with the development of moderate COVID-19. Being female seemed to delay the time to clinical improvement. |
|
Optimization of COVID-19 testing accuracy with nasal anatomy education |
Li, L, Shim, et al |
American Journal of Otolaryngology - Head and Neck Medicine and Surgery |
Healthcare Response | Réponse des soins de santé |
Objective: To assess the effect of nasal anatomy education on medical providers' comfort level and knowledge base in
performing accurate SARS-CoV-2 (COVID) testing. 16 out of 17 nurses performed fewer than 10 COVID tests prior to the educational session (94%). Reported challenges with COVID testing included patient discomfort (79.6%), inability to pass the test swab (23.5%)
and nasal bleeding (11.8%). The number of providers comfortable with independently performing COVID testing increased from pre- to post-session (5 and 14, p = 0.013). The average number of correct responses to the 6-question nasal anatomy test increased following
the session (3.2 ± 1.2 to 5.1 ± 1.1, p = 0.003). Specifically, the number of providers able to localize the nasopharynx increased from 8 providers pre-session to 14 providers post-session (p = 0.04). |
|
Li, Q, Cheng, et al |
Journal of International Medical Research |
Clinical data| Données cliniques |
We herein report two cases of COVID-19 along with acute kidney injury following kidney transplantation. |
|
|
Liang, C, Niu, et al |
Biosci Rep |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study aimed to identify the active chemical constituents of "three formulas and three medicines" traditional Chinese
medicine (TCM) and investigate their mechanisms through interleukin-6 (IL-6) integrating network pharmacological approaches. The network pharmacology research showed that TCM could decrease IL-6 using several compounds, such as quercetin, ursolic acid, luteolin,
and rutin. Molecular docking results showed that the molecular binding affinity with IL-6 of all compounds except γ-aminobutyric acid was < −5.0 kJ/mol, indicating the potential of numerous active compounds in TCM to directly interact with IL-6, leading to
an anti-inflammation effect. Finally, Cytoscape 3.7.2 was used to topologize the biological processes and pathways of compounds, revealing potential mechanisms for COVID-19 treatment. |
|
|
SARS-CoV-2 in the bile of a patient with COVID-19-associated
gallbladder disease |
Liao, Y, Wang, et al |
Endoscopy |
Clinical data| Données cliniques |
We encountered an interesting case of COVID-19 in which SARS-CoV-2 was detected in the bile. |
|
Lièvre, A, Turpin, et al |
European journal of cancer |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this work, predictive factors for COVID-19 severity and mortality in cancer patients were investigated. The most
frequent cancers were digestive and thoracic. Altogether, 424 (33%) patients had a severe form of COVID-19 and 370 (29%) patients died. In multivariate analysis, independent factors associated with death were male sex (odds ratio 1.73, 95%CI: 1.18–2.52), The
Eastern Cooperative Oncology Group Performance Scale (ECOG PS) ≥ 2 (OR 3.23, 95%CI: 2.27–4.61), updated Charlson comorbidity index (OR 1.08, 95%CI: 1.01–1.16) and admission to ICU (OR 3.62, 95%CI 2.14–6.11). The same factors, age along with corticosteroids
before COVID-19 diagnosis, and thoracic primary tumour site were independently associated with COVID-19 severity. None of the anticancer treatments administered within the previous 3 months had any effect on mortality or COVID-19 severity, except for cytotoxic
chemotherapy in the subgroup of patients with detectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by reverse transcriptase polymerase chain reaction (RT-PCR), which was associated with a slight increase of the risk of death (OR 1.53; 95%CI:
1.00–2.34; p = 0.05). A total of 431 (39%) patients had their systemic anticancer treatment (such as chemotherapy, targeted or immune therapy) interrupted or stopped following diagnosis of COVID-19. |
|
|
Liu, H, Luo, et al |
International Journal of Medical Sciences |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Forty HCWs with COVID-19 were included in this study and 30 enrolled for imaging assessment. Disease was divided into
four stages based on time from onset. The cohort included 33 female and 7 male cases, with a median age of 40 years. Six had underlying comorbidities. More than half of the cases were nurses (22, 55%). Each stage included 39, 37, 34 and 32 CTs, respectively.
Bilateral lesions, multifocal lesions and lesions with GGO pattern occurred in both lower lobes at all stages. The crazy-paving pattern (20, 54%), air bronchogram (13, 35%), and pleural effusion (2, 5%) were the most common CT features in stage 2. Consolidation
score peaked in stage 2 whereas total lesions score peaked in stage 3. |
|
|
Liu, M, Zhang, et al |
BMC Public Health |
Mental Health |
|
A total of 4991 respondents were randomly recruited from a national online panel from February 12th, 2020 to February
14th, 2020, a period when the number of COVID-19 cases surpassed 10,000 in a single day, with the total cases in China reaching up to 90,000. The relationships between media exposure of COVID-19 information, social and geographical proximity to COVID-19, risk
perceptions were assessed using hierarchical ordinary least squares regression analysis. The media exposure to COVID-19 information was differently associated with anxiety. Meanwhile, the anxiety level was found to be high in respondents who personally knew
someone infected with COVID-19 or those who living in an area with reported cases. Respondents who perceived more risks also reported a higher level of anxiety. |
|
|
Are stay-at-home orders more difficult to follow for low-income groups? |
Lou, J, Shen, et al |
Journal of Transport Geography |
Public Health response| Interventions de santé publique |
In this paper, we examine social distance behavior changes for lower income populations. We conduct a comparative analysis
of responses between lower-income and upper-income groups and assess their relative exposure to COVID-19 risks. we find social distance policy effect on the lower-income group is smaller than that of the upper-income group, by as much as 46% to 54%. Our explorations
of the mechanisms behind the disparate effects suggest that for the work-related trips the stay-at-home orders do not significantly reduce low income work trips and this result is statistically significant. That is, the share of essential business defined
by stay-at-home orders is significantly negatively correlated with income at county level. In the non-work-related trips, we find that both the lower-income and upper-income groups reduced visits to retail, recreation, grocery, and pharmacy visits after the
stay-at-home order, with the upper-income group reducing trips more compared to lower-income group. |
|
Luan, B, Huynh, et al |
J Phys Chem Lett |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Leveraging today’s superb computing power, we propose a fully automated in silico protocol for quickly identifying
possible mutations in a monoclonal antibodies (mAbs)(e.g., CB6) to enhance its binding affinity for S-protein for the design of more efficacious therapeutic mAbs. |
|
|
Lumley, SF, Eyre, et al |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
Epidemiology| Épidémiologie Immunology | Immunologie |
SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and
15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). |
|
|
Luo, M, Huang, et al |
Chinese Traditional and Herbal Drugs |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective: To build a model to predict critically ill-patients with coronavirus disease 2019 (COVID-19), and provide
a new idea for the rapid identification of clinical progression in the early stage of critically ill-patients. The sensitivities of age, fever, neutrophil ratio, lymphocyte ratio, serum creatinine (Scr) and combined diagnosis were 0.664, 0.671, 0.607, 0.669,
0.302 and 0.710, respectively; The specificities were 0.669, 0.585, 0.795, 0.685, 0.895 and 0.802, respectively; The area under the curve (AUC) were 0.725, 0.628, 0.721, 0.681, 0.590 and 0.795, respectively; The AUC of combined diagnosis was higher than that
of single diagnosis (P < 0.05). |
|
|
Mahajan, Swapnil, Bhojak, et al |
bioRxiv |
Immunology | Immunologie |
In this study, we identified immunodominant CD8 T-cell epitopes in the RBD and the non-RBD domain of the spike antigen
using a novel TCR-binding algorithm. A key finding of our study is that pre-existing T-cell immunity to SARS-CoV-2 is contributed by TCRs that recognize common viral antigens such as Influenza and CMV, even though the viral epitopes lack sequence identity
to the SARS-CoV-2 epitopes. |
|
|
Maiorana, Andrea, Meneghelli, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
In this study, we analyze the effectiveness of measures aimed at finding and isolating infected individuals to contain
epidemics like COVID-19, as the suppression induced over the effective reproduction number. We develop a mathematical model to compute the relative suppression of the effective reproduction number of an epidemic that such measures produce. This outcome is
expressed as a function of a small set of parameters that describe the main features of the epidemic and summarize the effectiveness of the isolation measures. In particular, we focus on the impact when a fraction of the population uses a mobile application
for epidemic control. Finally, we apply the model to COVID-19, providing several computations as examples, and a link to a public repository to run custom calculations. These computations display in a quantitative manner the importance of recognizing infected
individuals from symptoms and contact-tracing information, and isolating them as early as possible. The computations also assess the impact of each variable on the suppression of the epidemic. |
|
|
Maiorano, T, Vagni, et al |
Sustainability (Switzerland) |
Mental Health |
|
Here, we investigated the direct and mediated effects of coping strategies and hardiness on secondary trauma among
Italian medical staff (physicians and nurses, n = 140) and emergency workers (firefighters, civil protection, and ambulance personnel, n = 100) involved in the first phase of the pandemic. The results show that nurses and physicians experienced higher levels
of emergency stress than emergency workers. Direct contact with COVID-19 patients, female sex, unexpected events, and lack of PPE were risk factors for emergency stress, while resilience and coping strategies played a protective role. Mediation analysis shows
that coping strategies and hardiness are protective factors and reduce the effect of stress on secondary trauma. |
|
|
Mansour, E |
Journal of Librarianship and Information Science |
Public Health response| Interventions de santé publique |
This study proposes to investigate the knowledge and perception of students in the Department of Library and Information
Science at South Valley University in Upper Egypt about the state’s dealing with the outbreak of the novel coronavirus known as COVID-19 that has been detected in Egypt in February 2020. The study found that there is no significant relationship between the
students’ gender and other variables of the study according to the statistics used. It also showed that the most popular information sources mentioned by Department of Library and Information Science students to get information related to the coronavirus were
social media and the Internet/Web. The publication/dissemination of information and its availability were badly perceived by the students. About one-third of them questioned the government’s ability to deal with the novel coronavirus. They highly believe in
the role of information transparency in fighting both administrative and human corruption. The students emphasized the citizens’ right to criticize the government when it does not comply with the transparency, as well as the right to access any information
owned by it in any formats at any time. They were dissatisfied with the government’s ability to retrieve information, organize, store, have legislations, and own a good database of citizens, as well as its capabilities, in terms of transparency, competence,
benevolence, honesty, accuracy, efficiency/effectiveness, practicality, and confidence, in relation to the outbreak of the novel coronavirus. Finally, the study indicated that barriers, such as the spread of administrative and human corruption, security restrictions,
and the fragility of the freedom to disclose government information, were highly significant by the surveyed students. |
|
|
Márquez-Salinas, Alejandro, Fermín-Martínez, et al |
medRxiv |
Epidemiology| Épidémiologie |
Here, we evaluated the influence of aging metrics PhenoAge and PhenoAccelAge on the adaptive responses to SARS-CoV-2
infection in hospitalized patients. We included 1069 subjects of whom 401 presented critical illness and 204 died. PhenoAge was a better predictor of adverse outcomes and lethality compared to chronological age (CA) and SpO2 and its predictive capacity was
sustained for all age groups. Patients with responses associated PhenoAccelAge >0 had higher risk of death and critical illness compared to those who had values according to CA (log-rank p<0.001). Using unsupervised clustering we identified four adaptive responses
to SARS-CoV-2 infection: 1) Inflammaging associated with CA, 2) adaptive metabolic dysfunction associated with cardio-metabolic comorbidities, 3) adaptive unfavorable hematological response, and 4) response associated with favorable outcomes. |
|
|
Martínez-Fleta, P, Alfranca, et al |
J Immunol |
Coronavirology| Coronavirologie Immunology | Immunologie |
We addressed whether other nonstructural viral proteins, not incorporated into the infectious viral particle, specifically
the viral cysteine-like protease, might also be potent immunogens. Using ELISA tests, coating several SARS-CoV-2 proteins produced in vitro, we describe that COVID-19 patients make high titer IgG, IgM, and IgA Ab responses to the Cys-like protease from SARS-CoV-2,
also known as 3CLpro or Mpro, and it can be used to identify individuals with positive serology against the coronavirus. Higher Ab titers in these assays associated with more-severe disease, and no cross-reactive Abs against prior betacoronavirus were found.
Remarkably, IgG Abs specific for Mpro and other SARS-CoV-2 Ags can also be detected in saliva. |
|
|
Mellis, AM, Potenza, et al |
Journal of substance abuse treatment |
Healthcare Response | Réponse des soins de santé |
We aim to assess the rapid changes to treatment and support services for individuals with substance use disorders (SUDs),
including those in long-term recovery, and their loved ones due to COVID-19. Our findings suggest that individuals with a history of using multiple substances may be at greater risk for poor outcomes due to COVID-19, even in the face of expansion of telehealth
service access. |
|
|
Low-threshold SARS-CoV-2 testing facility for hospital staff: Prevention of COVID-19
outbreaks? |
Menting, T, Krause, et al |
International journal of hygiene and environmental health |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
The SARS-CoV-2 pandemic has shown to significantly impact mental and physical health of HCW. Thus, implementation of
testing facilities supporting HCW are urgently needed. In the absence of easily accessible public SARS-CoV-2 testing facilities low-threshold SARS-CoV-2 testing facilities in hospitals with rapid testing resources help to identify SARS-CoV-2 infected employees
with absent or mild symptoms, thus stopping the spread of infection in vulnerable hospital environments. |
|
Mills, J |
Journal of Black Studies |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper develops a SEIRCRT model that integrates the Institute for Disease Modeling’s SEIR model and Critical Race
Theory (CRT) to answer the question: What is in a SEIRCRT model? SEIRCRT provides a basic modeling structure from a CRT lens to simulate, predict and forecast COVID-19 cases, comorbidities affecting African Canadians, and deaths through predictive modeling. |
|
|
Adapting the reverse pyramid airplane boarding method for social distancing in
times of COVID-19 |
Milne, RJ, Cotfas, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
We adapt the Reverse Pyramid method for social distancing when an airplane is boarded using a jet bridge that connects
the terminal the airplane’s front door. We vary the number of boarding groups from two to six and use stochastic simulation and agent-based modelling to show the resulting impact on four performance evaluation metrics. |
|
Miner, JJ, Platt, et al |
Cell Rep |
Coronavirology| Coronavirologie |
Here, we report our studies of immune-mediated regulation of Zika virus (ZIKV), herpes simplex virus 1 (HSV-1), and
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the human cornea. In human corneal explants, we report that ZIKV does not replicate efficiently and that SARS-CoV-2 does not replicate at all. |
|
|
Thermodynamic evaluation of the impact of DNA mismatches
in PCR-type SARS-CoV-2 primers and probes |
Miranda, Pamella, Weber, et al |
bioRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We calculate the hybridization temperatures of primer/probe sets after aligning to SARS-COV-2, SARS-COV-1 and non-SARS
genomes, considering all possible combinations of single, double and triple consecutive mismatches. We obtained the alignments of 19 PCR primers sets that were recently reported for the detection of SARS-CoV-2 and to 21665 SARS-CoV-2 genomes as well as 323
genomes of other viruses of the coronavirus family of which 10 are SARS-CoV-1. Some primer/probe sets only align substantially to most SARS-CoV-2 genomes if mismatches are taken into account. Unfortunately, by the same mechanism, almost 75% of these sets also
align to some SARS-CoV-1 and non-SARS viruses. |
|
Montagnon, R, Rouffilange, et al |
Journal of Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
We aimed to assess the influence of the Coronavirus Disease 2019 (COVID-19) pandemic on ED visits and the impact on
the handling of patients requiring urgent revascularization. The COVID-19 pandemic probably dissuaded “non-critical” patients from coming to the hospital, whereas the same number of patients with a critical illness attended the ED as attended prior to the
pandemic. There does not seem to have been any effect of the pandemic on patients requiring reperfusion therapy (STEMI and stroke). |
|
|
Moon, SJ, Rhee, et al |
Diabetes and Metabolism Journal |
Epidemiology| Épidémiologie |
We conducted a nationwide population-based cohort study to evaluate the relationship between diabetes and COVID-19
severity in South Korea. Of 5,307 COVID-19 patients, the mean age was 56.0±14.4 years, 2,043 (38.5%) were male, and 770 (14.5%) had diabetes. Diabetes was associated with worse clinical outcomes in Korean patients with COVID-19, independent of other comorbidities.
Therefore, patients with diabetes and COVID-19 should be treated with caution. |
|
|
33096114; Preventing the development of severe COVID-19 by modifying immunothrombosis |
Morris, G, Bortolasci, et al |
Life Sciences |
Coronavirology| Coronavirologie Immunology | Immunologie |
This paper describes the processes involved in the pathophysiology of COVID-19 from the initial infection and subsequent
destruction of type II alveolar epithelial cells by SARS-CoV-2 and culminating in the development of acute respiratory distress syndrome (ARDS). |
|
Muggeo, A, Alauzet, et al |
Journal of Clinical Virology |
Clinical data| Données cliniques |
From March 1 to April 29, 2020, we screened 24257 patients for SARS-CoV-2 (RT-PCR) in two of the three Teaching Hospitals
of the Grand Est region (Nancy and Reims). Of all the patients screened, 5428 (22.4 %) were positive for SARS-CoV-2. Among the hospitalized patients, we recovered available status of infection for other respiratory pathogens for 232 patients determined by
multiplex PCR. |
|
|
33094715; A large national outbreak of COVID-19 linked to air travel,
Ireland, summer 2020 |
Murphy, N, Boland, et al |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
An outbreak of 59 cases of coronavirus disease (COVID-19) originated with 13 cases linked by a 7 h, 17% occupancy flight
into Ireland, summer 2020. The flight-associated attack rate was 9.8–17.8%. Spread to 46 non-flight cases occurred country-wide. Asymptomatic/pre-symptomatic transmission in-flight from a point source is implicated by 99% homology across the virus genome in
five cases travelling from three different continents. |
|
Nakao, M, Matsuda, et al |
Journal of Cardiology Cases |
Clinical data| Données cliniques |
An 84-year-old man with coronavirus disease 2019 pneumonia developed ST-segment-elevation myocardial infarction and
was brought to the catheterization laboratory. His angiogram showed a haziness in distal right coronary artery, and optical coherence tomography (OCT) exhibited vascular spasm and OCT-defined plaque erosion, which were thought to be the causes of non-obstructive
myocardial infarction. |
|
|
Nakashima, A, Takeya, et al |
Informatics in Medicine Unlocked |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Here, we evaluated the applicability of public database annotations to estimate the virulence, transmission trends
and origins of emerging SARS-CoV-2 variants. Among the detectable multiple mutations, we retraced the mutation in the spike protein. |
|
|
Niu, X, Yue, et al |
ISPRS International Journal of Geo-Information |
Epidemiology| Épidémiologie |
This study analyzed massive intercity movement data from Baidu and epidemic data to study how intercity population
outflows affected the spatiotemporal spread of the epidemic. This study further investigated how urban factors influenced the spatiotemporal spread of COVID-19. The analysis indicates that intercity movement was an important factor in the spread of the epidemic
in China, and the impact of intercity movement on the spread was heterogeneous across different classes of cities. |
|
|
Nzaji, MK, Mwamba, et al |
Journal of Multidisciplinary Healthcare |
Public Health response| Interventions de santé publique |
The aim of this study was to determine the associated factors of non-adherence to public health and social measures
instructions. Among 1913 participants, 36.6% were defined as non-adherents. Non-adherence was associated with never studied and primary education level, unemployed status, living in Kamina (Haut-Lomami province), female gender of head of household, no attending
lectures/discussions about COVID-19, not being satisfied with the measures taken by the Ministry of Health, not been regularly informed about the pandemic, and bad knowledge about COVID-19. |
|
|
Ong, CSH, Lu, et al |
Urology |
Healthcare Response | Réponse des soins de santé |
The ureteric colic telemedicine service successfully and sustainably reduced the number of face-to-face consultations
and time to review without compromising on patient safety during the CO VID-19 pandemic. |
|
|
Mental state of central sterile supply department staff during COVID-19 epidemic
and CART analysis |
Pan, W, Hu, et al |
BMC Health Serv Res |
Mental Health |
|
Investigate the mental state of the central sterile supply department (CSSD) staff and relevant influencing factors
experienced during the COVID-19 epidemic. During the epidemic, the CSSD staff’s psychological resilience was at a low level; the anxiety level of the CSSD nurses was higher than that of the CSSD logistic staff. Therefore, more attention should be given to
the mental health of the CSSD staff, including taking protective measures regarding the risk factors to ensure they can maintain a healthy mental state. |
|
Patrì, A, Pinchera, et al |
Intest Res |
Clinical data| Données cliniques |
Clinical report of COVID-19 (n=10) attending the Infectious Diseases Unit in Naples, Italy. |
|
|
Paykani, T, Zimet, et al |
BMC Public Health |
Public Health response| Interventions de santé publique |
Assess the effects of perceived social support on compliance with stay-at-home orders in response to a COVID-19 outbreak
during the Persian New Year (Nowruz) holydays. 20.5% of participants reported poor compliance with stay at home orders during the first 2 weeks of Nowruz. Clear social gradients were not found in stay-at-home compliance. When controlling socio-demographic
factors, perceived social support, interestingly, both fostered and hindered people's compliance with stay at home orders, depending on the source of support from family members (OR = .874, 95% CI = .803, .950, p < .005), friends (OR = 1.147, 95% CI = 1.076,
1.222, p < .001) and a significant other person (OR = .926, 95% CI = .849, 1.010, p = .084). |
|
|
[Perception of the COVID-19 Pandemic among Pneumology Professionals in Germany] |
Peine, A, Paffenholz, et al |
Pneumologie |
Healthcare Response | Réponse des soins de santé |
The study presents the results of an opinion evaluation among 513 pneumology specialists in Germany in the period from
March 27th to April 11th, 2020. |
|
Perveen, A, Hamzah, et al |
Indian Journal of Community Health |
Mental Health |
|
Evaluate the psychological health issues, stress, anxiety and depression, among the adult population during the movement
control period of COVID-19. There is significant prevalence of psychological health issues among adults during the adverse unavoidable circumstance due to COVID-19 Pandemic movement control order. |
|
|
Lack of antibodies to SARS-CoV-2 in a large cohort of previously infected persons |
Petersen, LR, Sami, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Immunology | Immunologie |
Determine the proportion IgG seronegative and predictors for seronegativity among persons previously infected with
SARS-CoV-2. In the study population, previous RT-PCR confirmed infection approximately one in 16 persons lacked IgG antibodies. Absence of antibodies varied independently by illness severity, race/ethnicity, obesity, and immunosuppressive drug therapy. The
proportion seronegative remained relatively stable among persons tested up to 90 days post symptom onset. |
|
Pizzirusso, M, Carrion-Park, et al |
J Acquir Immune Defic Syndr |
Mental Health |
|
Physical symptoms were frequent and mild psychiatric symptoms common, but serious anxiety and depression were not often
endorsed by this group of PLWH at the acute height of the NYC COVID-19 pandemic. |
|
|
Pollet, Jeroen, Chen, et al |
bioRxiv |
Therapeutics| Thérapeutique Vaccine Research| Recherche sur les vaccins |
Report on the development of a SARS-CoV-2 receptor-binding domain (RBD) protein, expressed at high levels in yeast
(Pichia pastoris), as a suitable vaccine candidate against COVID-19. |
|
|
The translational landscape of SARS-CoV-2 and infected
cells |
Puray-Chavez, Maritza, Tenneti, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Use ribosome profiling in SARS-CoV-2-infected cells, to identify structural elements that regulate viral gene expression,
alternative translation initiation events, and host responses regulated by mRNA translation. The study found ribosome density was low within the SARS-CoV-2 frameshifting element but high immediately downstream, which suggests the utilization of a highly efficient
ribosomal frameshifting strategy. In SARS-CoV-2-infected cells, although many chemokine, cytokine and interferon stimulated genes were upregulated at the mRNA level, they were not translated efficiently, suggesting a translational block that disarms host innate
host responses. |
|
Puri, M, Agrawal, et al |
Eval Health Prof |
Healthcare Response | Réponse des soins de santé |
Despite the existing triaging strategy at the Obstetric unit of a tertiary hospital in New Delhi, where all COVID-19
suspects obstetric patients were tested and admitted in orange zone and non-suspects in green zone, asymptomatic COVID-19 positive patients were found admitted in the green zone. This was the trigger to undertake a quality improvement (QI) initiative to prevent
the admission of asymptomatic COVID-19 positive patients in green zones. The admission of unsuspected COVID-19 positive cases in the green zone of the unit reduced from 20% to 0% during the stipulated period. There was a significant reduction in the number
of HCWs, posted in the green zone, being quarantined or test positive for COVID-19 infection as well. |
|
|
Challenges in Brain Death Determination and Apnea Testing for Patients
with COVID-19 |
Radaideh, Y, Garg, et al |
Journal of Stroke and Cerebrovascular Diseases |
Clinical data| Données cliniques |
Patient was a 57-year-old male admitted with a right frontoparietal intracerebral hemorrhage and diagnosed with COVID-19
at the time of admission. The intracerebral hemorrhage evolved to significant cerebral edema and herniation, and the case underwent apnea test using a method involving a t-piece and an HME filter. Patient was successfully pronounced brain dead using a safe
method to minimize exposure to SARS-CoV-2. |
|
Rahman, MS, Azad, et al |
Science of the Total Environment |
Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions
de sant&eacute; publique |
In this study, we applied ground- and satellite-based data of five criteria air pollutants (PM2.5, NO2, SO2, O3, and
CO) and meteorological factors from March 8 to May 15, 2020 (before, partial-, and full-lockdown). The generalized additive models (GAMs), wavelet coherence, and random forest (RF) model were employed to explore the relationship between air quality indicators
and COVID-19 transmission in Dhaka city. The results of GAMs revealed that a 1-unit increase in CO was associated with a 10.7% increased risk of COVID-19 infection rate during the partial lockdown. This research has identified the three potential factors including
MT, RH and O3 may contribute to the COVID-19 infection rate in the Dhaka city. |
|
|
Raman, R, Madhusudan, et al |
Indian J Pediatr |
Healthcare Response | Réponse des soins de santé |
We hence attempted to compare children based on symptomatology at presentation to the pediatric emergency department
during the pandemic phase (April–July 2020) with the same period in 2019. We observed a 65% drop in admission to the pediatric emergency department in 2020 (n = 280) as compared with a similar time frame last year (n = 790). The most significant decrease was
observed in admissions due to respiratory and gastrointestinal emergencies. We also observed that a significantly higher proportion of children admitted into the emergency department required ICU care in 2020 to 2019 |
|
|
Rinzivillo, Calogero, Conte, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We study a new fractal model for prediction of contagions of CoViD-19 using experimental data from October 10, 2020
to predict contagions from November until February 2021 in Italy. We obtain that the time of the peak is estimated to be at November 11, 2020 when number of contagions will be about 38489 cases. |
|
|
Phylogeography of 27,000 sars-cov-2 genomes: Europe as the major source of the
covid-19 pandemic |
Rito, T, Richards, et al |
Microorganisms |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
We used 26,869 SARS-CoV-2 genomes to build a phylogeny with 20,247 mutation events and adopted a phylogeographic approach.
We confirmed that the phylogeny pinpoints China as the origin of the pandemic. However, a single specific East Asian founder underwent massive radiation in Europe and became the main actor of the subsequent spread worldwide during March 2020. This lineage
accounts for the great majority of cases detected globally and even spread back to the source in East Asia. |
|
Roberts, HW, Akram, et al |
J Cataract Refract Surg |
Clinical data| Données cliniques |
This case report describes a negative result for antigen testing for the SARS-CoV-2 virus in an aqueous sample taken
during the management of suspected herpes simplex keratitis, in a patient with confirmed SARS-CoV-2 based on antigen testing of high nasal swab. The implications of no viral load detectable in the aqueous sample are discussed in context of routine phacoemulsification
surgery during the SARS-CoV-2 pandemic. |
|
|
Rohit, G, Hariprasad, et al |
International Journal of Surgery Case Reports |
Clinical data| Données cliniques |
We present a case of 30-year-old male with an alleged history of an accidental fire arm injury. His rapid antigen for
COVID was positive. Contrast enhanced computed tomogram abdomen was suggestive of multiple bowel injuries. Perforated sites were sealed by primary repair and loop ileostomy was performed. Patient was discharged on post-operative Day 17 with satisfactory clinical
improvement. |
|
|
Rolandi, E, Vaccaro, et al |
International Journal of Environmental Research and Public Health |
Mental Health |
|
The present study aimed at exploring how older adults, previously trained for Social Networking Sites (SNSs) use, experienced
the lockdown period. We collected information on SNSs use, self-perceived loneliness, and social engagement with family and friends. Participants trained for SNSs use reported significantly higher usage of SNSs and reduced feeling of being left out. Compared
to pre-lockdown levels, individuals trained for SNSs use showed a lighter reduction in social contacts. |
|
|
Salameh, P, Hajj, et al |
Psychiatry research |
Mental Health |
|
This study explored the independent and combined effects of the COVID-19 and economy-related variables on stress and
anxiety among Lebanese adults in a developing country facing a severe socio-economic crisis and political turmoil. Higher stress and anxiety were associated with younger age, female gender, previous higher socio-economic status, having a family member with
a chronic disease, fear of not getting access to treatment, fear of COVID-19, and physical violence at home. |
|
|
Saleem, M, Alenazi, et al |
Indian Journal of Community Health |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to evaluate the levels of information regarding the current emerging outbreak of COVID-19
among medical and dental students at universities in Saudi Arabia through an online questionnaire. The majority of the respondents were aware of the COVID-19 pandemic (94.7%). Internet was the main source of information (63.1%). Respondents of the college
of Medicine were more aware about COVID-19 than respondents of the college of Dentistry. |
|
|
A Predictive Model for Confirmed Cases of COVID-19 in Nigeria |
Samson, Timothy Kayode, Ogunlaran, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
This study builds an ARIMA model for forecasting the confirmed cases of COVID-19 in Nigeria based on Box-Jenkins methodology.
Results showed that among the ARIMA models, the ARIMA (2,1,0) outperformed other proposed models. The forecasts showed an upsurge in the confirmed cases of COVID-19 in Nigeria if the current relaxation of the lockdown continues. |
|
Sarkodie, BD, Mensah, et al |
Journal of Medical Imaging and Radiation Sciences |
Clinical data| Données cliniques |
We report chest CT findings in 28 patients diagnosed with COVID-19 in Ghana. 17 (66.7%) patients showed predominantly
ground glass opacities while 12 (42.9%) had evidence of consolidation predominantly. In 26 (92.9%) of the patients, the opacities were bilateral and peripheral in distribution. None of these patients had pleural effusion. |
|
|
Sartorius, Benn, Lawson, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
We applied a Bayesian space–time SEIR model to assess the spatiotemporal variability of COVID-19 caseloads (transmission)
and deaths at small-area scale in England. While non-pharmaceutical interventions (that is, reductions in population mobility and social distancing) had a profound impact on the trajectory of the first wave of the COVID-19 outbreak in England, increased population
mobility appears to have contributed to the current increase signalling the start of the second wave. A number of contiguous small-areas appear to be at a significant elevated risk of high COVID-19 transmission, many of which are also at increased risk for
higher mortality rates. |
|
|
Schirinzi, A, Cazzolla, et al |
Microorganisms |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
The aim of this study was to correlate the blood levels of CRP, IL-6, presepsin, procalcitonin, D-Dimer with Human
epididymis secretory protein 4 (He4), to identify the predictive values of these biomarkers for the evolution of the disease and to evaluate the possible role of HE4 in the defense mechanisms of innate immunity at the level of oral cavity, nasopharynx and
respiratory tract. Of the 86 patients hospitalized in Bari, Italy that fulfilled inclusion criteria, 19 died. Results demonstrated the important correlation between He4, IL6 and presepsin, an excellent accuracy of He4 and IL6 and showed a probable role of
He4 in the innate immunity in particularly at the level of oral cavity, nasopharynx and respiratory tract. |
|
|
Schumann, Sara, Kaiser, et al |
medRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The present paper will introduce the small molecule MP1032, describe its mode of action, and give rationale why it
is a promising option for prevention/treatment of SARS-CoV-2-induced cytokine storm. The physiological action of MP1032 is based on a multi-target mechanism including localized, self- limiting antioxidant activities that were demonstrated in a model of lipopolysaccharide
(LPS)-induced joint inflammation. Efficacy has been preclinically elucidated in LPS-induced endotoxemia, a model with excessively activated immune responses that shares many similarities to COVID-19. So far, during oral clinical development with three-months
daily administrations, no serious adverse drug reactions occurred highlighting the outstanding safety profile of MP1032. |
|
|
Identification, Isolation, Propagation And Inactivation
Of SARS-CoV2 Isolated From Egypt |
Seadawy, Mohamed Gomaa |
bioRxiv |
Coronavirology| Coronavirologie |
COVID-19 appeared in Egypt in Feb 2020. The samples were taken from patients with COVID-19 symptoms at military hospital
in Egypt and transported to the main chemical laboratories under all the biosafety measures according to WHO guidelines. All samples were tested with RT-PCR. Positive samples were cultured using VeroE6 cell lines. The propagated virus was isolated and inactivated.
The isolated virus was sequenced using next generation sequencing and submitted into gene bank. This study provides an isolation, propagation and inactivation methodology which is valuable for production of inactivated vaccines against SARS-CoV2 in Egypt. |
|
Sethuraman, U, Kannikeswaran, et al |
American Journal of Emergency Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We report the clinical and laboratory presentations and outcomes of 34 children with MIS-C who were evaluated within
a 12 week period at a pediatric emergency department (PED) of single institution in Michigan. These cases presented approximately three weeks after the peak of adult SAR-CoV-2 related deaths occurred in the state. While many children presented with clinical
characteristics similar to incomplete Kawasaki disease (KD), they also exhibited certain unique features which differentiated MIS-C from KD. The information presented below will aid clinicians with early recognition, evaluation and management of MIS-C in the
emergency department. |
|
|
Shah, P, Owens, et al |
J Hypertens |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The primary objective of this study is to determine the effect of baseline use of angiotensin-converting enzyme inhibitor
(ACE-i)/AT1 blocker (ARB) on mortality in hospitalized coronavirus disease 2019 (Covid-19) African-American patients. In this retrospective study, we analyzed data using electronic medical records from all hospitalized Covid-19 African-American patients, who
either died in the hospital or survived to discharge between 2 March and 22 May 2020. Out of 531 patients included in the analysis, 207 (39%) were on ACE-i/ARB at baseline. Patients in ACE-i/ARB group were older (64 vs. 57 years, P < 0.001), and had higher
prevalence of hypertension (96.6 vs. 69.4%, P < 0.001) and diabetes mellitus (55.6 vs. 34.9%, P < 0.001). Baseline use of ACE-i/ARB does not worsen outcomes in hospitalized Covid-19 African-American patients. |
|
|
Shanbhag, NM, Duncan, et al |
Oncologist |
Healthcare Response | Réponse des soins de santé |
In total, 42 physicians (16 oncologists and 36 non‐oncologists) took part in the online meeting and the premeeting
survey. The postmeeting survey was answered by 69% (29/42) of physicians. The premeeting and the postmeeting survey forms were different for the oncologists and the non‐oncologists. All the physicians considered patients with cancer to be at a higher risk
for COVID‐19 infection. Before the meeting, 75% (12/16) of the oncologists and 58.3% (21/36) of other physicians agreed that the pandemic had caused delay in diagnosis. Nearly 90% (9 oncologists and 17 non‐oncologists) of physicians who took the postmeeting
survey agreed that the discussion had provided ideas for avoiding delay in diagnosis during the pandemic. |
|
|
Shea, Katriona, Borchering, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
We convened multiple modeling teams to evaluate reopening strategies for a mid-sized county in the United States, in
a novel process designed to fully express scientific uncertainty while reducing linguistic uncertainty and cognitive biases. For the scenarios considered, the consensus from 17 distinct models was that a second outbreak will occur within 6 months of reopening,
unless schools and non-essential workplaces remain closed. Up to half the population could be infected with full workplace reopening; non-essential business closures reduced median cumulative infections by 82%. Intermediate reopening interventions identified
no win-win situations; there was a trade-off between public health outcomes and duration of workplace closures. Aggregate results captured twice the uncertainty of individual models, providing a more complete expression of risk for decision-making purposes. |
|
|
Sheikh, MK, Chaudahry, et al |
International Journal of Current Research and Review |
Mental Health |
|
Descriptive Study was conducted by providing E-Questionnaire and personal information sheet. 200 participants with
the age group of 25-60 years both genders were selected according to the inclusion criteria. Statistical analysis was done using a paired and unpaired t-test. The outcome was measured by using PHQ-9 Questionnaire and personal information form. The Above Conducted
study Showed that there is a state of depression is present in the young teachers who are taking online lectures because of COVID-19 Pandemic situation. |
|
|
Shi, J, Lu, et al |
Am J Chin Med |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study aimed to investigate the efficacy of Traditional Chinese Medicine (TCM) decoction with different intervention
timepoints in the treatment of coronavirus disease 2019 (COVID-19) patients. We retrospectively collected the medical records and evaluated the outcomes of COVID-19 patients that received TCM decoction treatment at different timepoints. A total of 234 COVID-19
patients were included in this study. Patients who received TCM decoction therapy within 3 days or 7 days after admission could achieve shorter hospitalization days and disease periods compared to those who received TCM decoction decoction ≥ 7 days after admission
(all p<0.05). Logistic models revealed that more days from TCM decoction to admission ≥7 days might be a risk factor for long hospitalization days, disease period, and slower negative-conversion of SARS-CoV-2 (all p<0.01). Conclusively, our results suggest
that TCM decoction therapy should be considered at the early stage of COVID-19 patients. |
|
|
High-dimensional single-cell analysis reveals the immune characteristics of COVID-19 |
Shi, W, Liu, et al |
Am J Physiol Lung Cell Mol Physiol |
Clinical data| Données cliniques Immunology | Immunologie |
In this study, we explored the characteristic peripheral cellular profiles of patients with COVID-19 in both acute
and convalescent phases by single-cell mass cytometry (CyTOF). Using a combination of algorithm-guided data analyses, we identified peripheral immune cell subsets in COVID-19, and revealed CD4(+) T cell depletion, T cell differentiation, plasma cell expansion,
and the reduced antigen presentation capacity of innate immunity. Notably, COVID-19 induces a dysregulation in the balance of monocyte populations by the expansion of the monocyte subsets. Collectively, our results represent a high-dimensional single-cell
profile of the peripheral immune response to SARS-CoV-2 infection. |
|
Silva, Gcda, Abe, et al |
Int Braz J Urol |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
The aim of this study is to evaluate if uro-oncological surgeries at pandemic are safe. We evaluated patients who underwent
uro-oncological procedures. Epidemiological data, information on COVID-19 infection related to surgery and clinical characteristics of non-survival operative patients with COVID-19 infections were analyzed. From 213 patients analyzed, Covid-19 symptoms were
noticed in 8 patients at preoperative process or at hospital admission postponing operation; 161 patients were submitted to elective surgery and 44 to emergency surgery. From patients submitted to elective surgeries, we had 1 patient with laboratory confirmation
of COVID-19 (0,6%), with mild symptoms and quick discharge. From the urgencies group, we had 6(13%)patients tested positive; 5 were taken to ICU with 4 deaths. Elective uro-oncological procedures at the COVID-19 epidemic period in a COVID-19-free Institute
are safe, and patients who need urgent procedures, with a long period of hospitalization, need special care to avoid COVID-19 infection and its outcomes. |
|
|
Sinegubova, MariaV, Orlova, et al |
bioRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
In this study we created two expression constructs encoding SARS-CoV-2 RBD with C-terminal c-myc and polyhistidine
tags. RBDv1 contained a native viral signal peptide, RBDv2 - human tPA signal peptide. We transfected a CHO DG44 cell line, selected stably transfected cells, and performed a few rounds of methotrexate-driven amplification of the genetic cassette in the genome.
For the RBDv2 variant, a high-yield clonal producer cell line was obtained. We developed a simple purification scheme that consistently yielded up to 30 mg of RBD protein per liter of the simple shake flask cell culture. The antigen produced by the described
technique is suitable for serological tests and similar applications |
|
|
Singh, H, Chawla, et al |
Indian Journal of Community Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this study we conducted a simulation on epidemiological model of COVID-19 to find out expected time off arrival
of infections and mortality in different countries and compared this to actual data. We observed that the actual arrival of infection in countries(2) is earlier than the date given as per simulation and preceding by 4 to 48 days. Such
a scenario does explain the increased mortality than was expected. |
|
|
Singh, Samer |
medRxiv |
Epidemiology| Épidémiologie |
The effect of Zinc (Zn) sufficiency/supplementation of the populations on the occurrence of COVID-19 and associated
severe illness/mortality remains unknown. A time-series association study was conducted on 23 different Zn sufficiency level but socially similar European populations/countries with supposedly similar confounders and stage of the pandemic, covering the period
from pre-peak-of-infections to post-peak-of-infections till flattening of the 1st wave of infections (12 March to 26 June). Comparison of these populations, consistently displayed a strong and significant correlation/covariation of populations′ Zn sufficiency/supplementation
status with the COVID-19 mortality Pearson′s r(23): 0.7893 to 0.6849, p-value92.5 % Zn sufficiency levels at all times as compared to populations with lower Zn sufficiency. Controlled trials or retrospective analysis of the adverse event patients′ data seem
warranted for ascertaining the basis of the observation in uncertain terms for allowing the harnessing of the full protective potential of the Zn supplementation for populations. |
|
|
The Impact of the COVID-19 Pandemic on Cardiac Electrophysiology Training: A Survey Study |
Singla, VK, Jain, et al |
J Cardiovasc Electrophysiol |
Healthcare Response | Réponse des soins de santé |
We sought to determine the impact of the COVID‐19 pandemic on the percentage of clinical cardiac EP (CCEP) fellows
in jeopardy of not meeting procedural volume requirements and overall sentiments regarding preparedness of fellows for independent practice. We surveyed CCEP fellows and program directors about baseline procedural volumes, curriculum changes due to the pandemic,
and attitudes about preparedness for board examinations and independent practice. Ninety‐nine fellows and 27 program directors responded to the survey. A minority of fellows and program directors reported concerns about meeting Accreditation Council for Graduate
Medical Education procedural requirements for devices (9%, 4%, respectively) and ablation (19%, 9%) or preparedness for independent practice after a two‐year fellowship. The COVID‐19 pandemic has resulted in a decrease in procedural volume for CCEP trainees,
but the majority of fellows and program directors do not anticipate major barriers to timely graduation. |
|
Sood, Sarita, Sharma, et al |
Research Square prepub |
Mental Health |
|
Based on the Complete State Model and the Competence-Based Model of mental health, this study examined the relationship
between fear of illness and subjective psychological well-being through perceived distress moderated by resilience in the context of COVID-19 pandemic. A cross-sectional survey using questionnaires was employed. Data were collected online from 384 participants
( 270 females and 114 males, age range= 15 to 29 years). The participants had indirect exposure to COVID-19 through information from the media. Results demonstrated that fear of illness significantly predicts subjective psychological well-being both directly
and indirectly. In addition, the moderated mediation effect of resilience was confirmed. This study contributes theoretically to a better understanding of the salutogenic effect of resilience on positive mental health during a pandemic. |
|
|
Soto-Rubio, A, Giménez-Espert, et al |
International Journal of Environmental Research and Public Health |
Mental Health |
|
The present study aimed to analyze the effect of psychosocial risks and emotional intelligence on nurses’ health, well-being,
burnout level, and job satisfaction during the rise and main peak of the COVID-19 pandemic in Spain. It is a cross-sectional study conducted on a convenience sample of 125 Spanish nurses. Multiple hierarchical linear regression models were calculated considering
emotional intelligence levels, psychosocial demand factors (interpersonal conflict, lack of organizational justice, role conflict, and workload), social support and emotional work on burnout, job satisfaction, and nurses’ health. Overall, this research data
points to a protective effect of emotional intelligence against the adverse effects of psychosocial risks such as burnout, psychosomatic complaints, and a favorable effect on job satisfaction. |
|
|
Sotoudeh, H, Tabatabaei, et al |
Acta Informatica Medica |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
For this purpose, this study was conducted to develop sensitive artificial intelligence (AI) models to assist radiologists
to decisively differentiate pneumonia due to COVID-19 versus influenza viruses. Cross sectional chest CT images (N=12744) from well-evaluated cases of pneumonias induced by COVID-19 or H1N1 Influenza viruses, and normal individuals were collected. We examined
the computer tomographic (CT) chest images from 137 individuals. The datasets were used for training (60%), validation (20%), and testing (20%) of the final models. Fine-tuned ResNet-50 model differentiated the pneumonia due to COVID-19 or H1N1 influenza virus
with accuracies of 96.7% and 92%, respectively. This model outperformed all others, i.e., InceptionV3, Wide ResNet, SqueezNet, VGG 16 and VGG 19. Fine-tuned and pre-trained image classifying models of AI enable radiologists to reliably differentiate the pneumonia
induced by COVID-19 versus H1N1 influenza virus. |
|
|
Staerk, Christian, Wistuba, et al |
arXiv |
Epidemiology| Épidémiologie |
This study illustrates the time-dependent evolution of effective infection fatality rate (IFR) over the course of the
pandemic, by combining age-group specific IFR estimates from multiple recent studies worldwide with publicly available German surveillance data. Three different methods for estimating (effective) IFRs are presented: (a) population-averaged IFRs based on the
assumption that the infection risk is independent of age and time, (b) effective IFRs based on the assumption that the age distribution of confirmed cases approximately reflects the age distribution of infected individuals, and (c) effective IFRs accounting
for age- and time-dependent dark figures of infections. Results for Germany show that effective IFRs are estimated to vary largely over time. A comparison of estimated IFRs with observed CFRs indicates that a substantial fraction of the time-dependent variability
in observed mortality can be explained by the evolving age distribution of infections. In addition, the vanishing gap between estimated effective IFR and observed CFR is discussed in light of the assumptions of the analysis. |
|
|
Suhud, Nur Amiera, Ling, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
This paper aims to investigate what and how the multifaceted social, physical, and governance factors affect the success
level of 7 selected Asia-Pacific countries (namely South Korea, Japan, Malaysia, Singapore, Vietnam, Indonesia, and New Zealand) in combatting the COVID-19 pandemic. Drawing on secondary data from February 2020 to June 2020, the success or severity level of
a country was measured by cumulative positive cases, average daily increase, and the mortality rate. The findings show that Vietnam (1st) and New Zealand (2nd) adopting most of the design principles of governance (with the scores of 15 and above) had successfully
eliminated the virus, while Indonesia (7th) and Japan (6th) were deemed least successful (scoring between 3-9), likely due to the low presence frequency of design principles. |
|
|
The
coronavirus disease 2019 main protease inhibitor from Andrographis paniculata (Burm.f) Ness |
Sukardiman, Ervina, M, et al |
Journal of Advanced Pharmaceutical Technology and Research |
Coronavirology| Coronavirologie |
This study aims to find COVID-19 main protease inhibitor from AP by the molecular docking method and determine the
toxicity profile of the compounds. The results obtained two compounds consisting of flavonoid glycosides 5,4'-dihydroxy-7-O-β-D-pyran-glycuronate butyl ester and andrographolide glycoside 3-O-β-D-glucopyranosyl-andrographolide have lower free binding energy
and highest similarity in types of interaction with amino acid residues compared to its co-crystal ligands (6LU7) and Indinavir or Remdesivir. The toxicity prediction of the compounds also reveals their safety. These results confirm the probability of using
AP phytochemical compounds as COVID-19 main protease inhibitors, although further research must be carried out. |
|
Sulasikin, Andi, Nugraha, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study is a quantitative analysis of the COVID-19 pandemic spreading using Jakarta as a case study for the evaluation
and decision-making process. In this paper, time series models such as the Holt's exponential smoothing and Auto-Regressive Integrated Moving Average (ARIMA) were used to forecast the number of COVID-19 cases in Jakarta between March 1 and July 6. Recently,
data exploration and comparative analysis of time series models have been conducted to determine the optimal models for forecasting COVID-19 confirmed cases. The result shows that ARIMA has the highest R-Squared (R2), and lowest (Mean Squared Error) MSE and
Root Mean Squared Error (RMSE) is the best model to forecast the upcoming number of infected cases of COVID-19 in Jakarta. |
|
|
Sun, Mengying, Shankar, et al |
Research Square prepub |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The aim of the study is to delineate sex differences in the expression of entry genes ACE2 and TMPRSS2, host responses
to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment. Using over 220,000 human gene expression profiles covering a wide range of age, tissues, and diseases, we found that male samples show higher expression levels of ACE2 and TMPRSS2, especially
in the older group (>60 years) and in the kidney. Analysis of 6,031 COVID-19 patients at Mount Sinai Health System revealed that men have significantly higher creatinine levels, an indicator of impaired kidney function. Further analysis of 782 COVID-19 patient
gene expression profiles taken from upper airway and blood suggested men and women present profound expression differences in responses to SARS-CoV-2. Computational deconvolution analysis of these profiles revealed male COVID-19 patients have enriched kidney-specific
mesangial cells in blood compared to healthy patients. Finally, we observed selective estrogen receptor modulators, but not other hormone drugs (agonists/antagonists of estrogen, androgen, and progesterone), could reduce SARS-CoV-2 infection in vitro. |
|
|
Tadesse, T, Tesfaye, et al |
Journal of Multidisciplinary Healthcare |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to determine the health worker’s knowledge, attitude, and practice of proper face mask utilization
and associated factors at police health faculties in Addis Ababa, Ethiopia, 2020. A cross-sectional, quantitative approach study was conducted from June to July 2020. The study covered 408 health professionals of all categories working in the different police
health facilities found in Addis Ababa, Ethiopia, during the study period. Data were collected using a pre-tested self-administered questionnaire adopted from different studies after getting consent from the study participants. The study showed that the overall
knowledge, attitude, and practice of the healthcare provider towards proper face mask utilization were 98 (33.5%), 185 (45.3%), and 272 (33.3%) respectively. Factors associated with proper utilization of face mask were educational status (AOR=10.4, 95% CI:
2.51, 43.32), police rank (AOR=0.2, CI: 0.05, 0.41), profession (AOR=7.7, 95% CI: 2.63, 22.65), and knowledge about face mask use (AOR=0.01, 95% CI: 0.003, 0.023). In this study, the level of knowledge and attitude towards face mask utilization was relatively
low, and the level of proper face mask utilization was quite low in comparison with some studies. |
|
|
Te Vrugt, M, Bickmann, et al |
Nat Commun |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique |
This article presents an extended model for disease spread based on combining a susceptible-infected-recovered model
with a dynamical density functional theory where social distancing and isolation of infected persons are explicitly taken into account. We show that the model exhibits interesting transient phase separation associated with a reduction of the number of infections,
and allows for new insights into the control of pandemics. |
|
|
Thomas, R, Michaleff, et al |
JMIR Public Health Surveill |
Public Health response| Interventions de santé publique |
This study aimed to investigate the uptake of the Australian Government's COVIDSafe app among Australians and examine
the reasons why some Australians have not downloaded the app. An online national survey, with representative quotas for age and gender, was conducted between May 8 and May 11, 2020. Participants were excluded if they were a health care professional or had
been tested for COVID-19. Of the 1802 potential participants contacted, 289 (16.0%) were excluded prior to completing the survey, 13 (0.7%) declined, and 1500 (83.2%) participated in the survey. Of the 1500 survey participants, 37.3% (n=560) had downloaded
the COVIDSafe app, 18.7% (n=280) intended to do so, 27.7% (n=416) refused to do so, and 16.3% (n=244) were undecided. Equally proportioned reasons for not downloading the app included privacy (165/660, 25.0%) and technical concerns (159/660, 24.1%). Other
reasons included the belief that social distancing was sufficient and the app was unnecessary (111/660, 16.8%), distrust in the government (73/660, 11.1%), and other miscellaneous responses (eg, apathy and following the decisions of others) (73/660, 11.1%).
In addition, knowledge about COVIDSafe varied among participants, as some were confused about its purpose and capabilities. Public health messages need to address the concerns of citizens, specifically privacy, data storage, and technical capabilities. |
|
|
Torii, S, Furumai, et al |
Science of the Total Environment |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study aims (1) to compare the whole process recovery of Pseudomonas phage φ6, a surrogate for enveloped viruses,
among combinations of primary concentration ultrafiltration (UF), electronegative membrane vortex (EMV), and polyethylene glycol precipitation (PEG)] and RNA extraction methods (spin column-based method using QIAamp Viral RNA Mini Kit and acid guanidinium
thiocyanate–phenol–chloroform extraction using TRIzol reagent) for three types of raw sewage and (2) to test the applicability of the method providing the highest φ6 recovery to the detection of SARS-CoV-2 RNA. Among the tested combinations, PEG+TRIzol provided
the highest φ6 recovery ratio of 29.8% to 49.8% (geometric mean). UF + QIAamp Viral RNA Mini Kit provided the second highest φ6 recovery of 6.4% to 35.8%. The comparable φ6 recovery was observed for UF + TRIzol (13.8–30.0%). PEG + QIAamp Viral RNA Mini Kit
provided only 1.4% to 3.0% of φ6 recovery, while coliphage MS2, a surrogate for nonenveloped viruses, was recovered comparably with PEG + TRIzol. This indicated that the nonenveloped surrogate (MS2) did not necessarily validate the efficient recovery for enveloped
viruses. EMV + QIAamp Viral RNA Mini Kit provided significantly different φ6 recovery (1.6–21%) among the types of raw sewage. Then, the applicability of modified PEG + TRIzol was examined for the raw sewage collected in Tokyo, Japan. Of the 12 grab samples,
4 were positive for SARS-CoV-2 CDC N1 and N3 assay. Consequently, PEG + TRIzol provided the highest φ6 recovery and allowed for the detection of SARS-CoV-2 RNA from raw sewage. |
|
|
Ustyuzhanin, D, Belkind, et al |
Russian Electronic Journal of Radiology |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The aim of this study was to retrospectively analyze lung CT images from the COVID-Center in the National Medical Research
Center of Cardiology (Moscow, Russia), to evaluate the most typical symptoms of viral pneumonia. The study included 746 patients (398 men and 348 women, age 61±15 years) admitted to the COVID-Center from April 14 to May 31, 2020 with a confirmed diagnosis
or suspicion of a new coronavirus infection (COVID-19). All patients underwent computed tomography (CT) upon admission, or within 2-3 days after hospitalization if CT was performed at the pre-hospital stage. 98 patients (13%) had no ground-glass opacity (GGO)
in the lung on the initial CT study, of which 18 patients (18%) had these changes during the second study. In 637 patients, GGO infiltration was bilateral or unilateral in several parts, which was considered as a high probability of a new coronavirus infection.
Mild lesions were observed in 164 patients (26%), medium in 261 patients (41%), severe in 164 (26%), and critical in 48 (8%). Crazy-paving pattern was detected in 139 patients (22%) in this group, areas of consolidation were observed in 347 patients (54%),
reticular pattern in 232 (36%). Pleural effusion was seen in 89 cases (14%), intra-thoracic lymph nodes enlargement in 69 (11%). CT is a fast, highly sensitive test that allows you to obtain important diagnostic information necessary for diagnosis and assessment
of the severity of the disease, which is crucial both for choosing of treatment strategy and for overcoming the epidemic process. |
|
|
Van Marcke, Cédric, Honoré, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The main objective was to determine the safety of systemic cancer treatment, measured by the rate of adverse events
according to the Common Terminology Criteria for Adverse Events, in SARS-CoV-2-positive patients compared with SARS-CoV-2-negative patients. ONCOSARS-1 was a prospective, single-center, academic observational study. Adult patients with solid tumors treated
in the oncology day unit with systemic anti-cancer therapy during the initial phase of the COVID-19 pandemic in Belgium were included. All patients (n=363) underwent severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) serological testing after the
peak of the pandemic in Belgium. Additionally, 141 of these patients also had a SARS-CoV-2 RT-PCR test during the pandemic. Twenty-two (6%) of the 363 eligible patients were positive for SARS-CoV-2 by RT-PCR and/or serology. Of these, three required transient
oxygen supplementation, but none required admission to the intensive care unit. Hematotoxicity was the only adverse event more frequently observed in SARS-CoV-2 -positive patients than in SARS-CoV-2-negative patients: 73% vs 35% (P<0.001). This association
remained significant (odds ratio (OR) 4.1, P=0.009) even after adjusting for performance status and type of systemic treatment. Hematological adverse events led to more treatment delays for the SARS-CoV-2-positive group: 55% vs 20% (P<0.001). Median duration
of treatment interruption was similar between the two groups: 14 and 11 days, respectively. Febrile neutropenia, infections unrelated to COVID-19, and bleeding events occurred at a low rate in the SARS-CoV-2-positive patients. Systemic anti-cancer therapy
appeared safe in ambulatory oncology patients treated during the COVID-19 pandemic. |
|
|
Varble, N, Blain, et al |
Eur Radiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to investigate and characterize associations between clinical, laboratory, and imaging features of
asymptomatic and pre-symptomatic patients with SARS-CoV-2. Seventy-four patients with RT-PCR-proven SARS-CoV-2 infection were asymptomatic at presentation. All were retrospectively identified from 825 patients with chest CT scans and positive RT-PCR following
exposure or travel risks in outbreak settings in Japan and China. CTs were obtained for every patient within a day of admission and were reviewed for infiltrate subtypes and percent with assistance from a deep learning tool. Forty-eight of 74 (65%) initially
asymptomatic patients had CT infiltrates that pre-dated symptom onset by 3.8 days. The most common CT infiltrates were ground glass opacities (45/48; 94%) and consolidation (22/48; 46%). Patient body temperature (p < 0.01), CRP (p < 0.01), and KL-6 (p = 0.02)
were associated with the presence of CT infiltrates. Infiltrate volume (p = 0.01), percent lung involvement (p = 0.01), and consolidation (p = 0.043) were associated with subsequent development of symptoms. COVID-19 CT infiltrates pre-dated symptoms in two-thirds
of patients. Body temperature elevation and laboratory evaluations may identify asymptomatic patients with SARS-CoV-2 CT infiltrates at presentation, and the characteristics of CT infiltrates could help identify asymptomatic SARS-CoV-2 patients who subsequently
develop symptoms. |
|
|
Vatele, Jordan, Gentile, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
The objective was to evaluate the impact of COVID-19’s lockdown on radiological examinations in Emergency Services.
Retrospective, multicentre analysis of radiological examinations requested, via our teleradiology network, from 2017 to 2020 during two timeframes (calendar weeks 5 to 8 and then 12 to 15). We included CT-scans or MRIs performed for strokes, multiple traumas
(body-CT, BC), cranial traumas (CTr) and acute non-traumatic abdominal pain (ANTAP). We evaluated the number and percentages of examinations performed, of those with a pathological conclusion, and of examinations involving the chest. The study included 25
centres in 2017, 29 in 2018, 43 in 2019 and 59 in 2020. From 2017 to 2019, the percentages of examinations were constant, which was also true for chest CTs. In 2020, examinations significantly decreased : suspected strokes decreased by 36% (1052 vs 675, p
<0.001), BC by 62% (349 vs 134, p <0.001), CTr by 52% (1853 vs 895, p <0.001) and for ANTAP, appendicitis decreased by 38% (145 vs 90, NS) sigmoiditis by 44% (98 vs 55, NS), and renal colic by 23% (376 vs 288, NS). The number of exams per centre decreased
by 13% (185.5 vs. 162.5, p <0.001) whereas the number of examinations of the "chest" region increased by 170% (1205 vs 3766, p <0.001). Teleradiology enabled us to monitor the impact of the COVID-19 pandemic management on emergency activities, showing a global
decrease in the population's use of care. |
|
|
Overlapping host pathways between SARS-CoV-2
and its potential copathogens: An in silico analysis |
Vavougios, GD |
Infection, Genetics and Evolution |
Coronavirology| Coronavirologie |
The aim of this study was to determine infection induced, host transcriptomic overlap between SARS-CoV-2 and other
pathogens. SARS-CoV-2 infection induced gene expression data were used for gene set enrichment analysis (GSEA) via the Enrichr platform. GSEA compared the extracted signature to VirusMINT, Virus and Microbe perturbations from Gene Expression Omnibus (GEO)
in order to detect overlap with other pathogen induced host gene signatures. For all analyses, a false discovery rate (FDR) <0.05 was considered statistically significant. Results: GSEA via Enrichr revealed several significantly enriched sub-signatures associated
with HSV1, EBV, HIV1, IAV, RSV, P.Aeruginosa, Staph. Aureus and Strep. Pneumoniae infections, among other pathogens (FDR < 0.05). These signatures were detected in at least 6 infection-induced transcriptomic studies from GEO and involved both bronchial epithelial
and peripheral blood immune cells. SARS-CoV-2 infection may function synergistically with other viral and bacterial pathogens at the transcriptomic level. Notably, several meta-analyses of COVID-19 cohorts have furthermore corroborated viral and bacterial
pathogens reported herein as coinfections with SARS-CoV-2. |
|
Pneumomediastinum and subcutaneous emphysema
after noninvasive ventilation in a COVID-19 patient |
Vazzana, N, Ognibene, et al |
Advances in Respiratory Medicine |
Clinical data| Données cliniques |
This case study describes a patient with pneumomediastinum associated with subcutaneous emphysema with severe respiratory
failure due to extensive interstitial pneumoniae correlated to SARS-CoV-2 infection which necessitated non-invasive ventilatory support. Prompt recognition is required during ventilatory support as it may promote its progression. |
|
Clinical Features of Patients with COVID-19:
is Temperature Screening Useful? |
Vilke, GM, Brennan, et al |
Journal of Emergency Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques Public health interventions*|
Interventions de sant&eacute; publique |
This study assessed the frequency of a fever ≥100.4°F and other symptoms associated with COVID-19 among patients in
the emergency department (ED) who were tested in the ED for the illness. This is a retrospective review of data from patients who were tested for acute COVID-19 infection from March 10, 2020 through June 30, 2020 at two EDs within the same health care system.
Data collected included temperature, the presence or recent history of COVID-19–related symptoms, and COVID-19 test results. Descriptive statistics are reported for presenting fever and other COVID-19–related symptoms alone and in combination with presenting
fever. A total of 6894 patients were tested for COVID-19. Among these, 330 (4.8%) tested positive for active infection. Of these patients, 64 (19.4%) presented with a fever ≥100.4°F (≥38.0°C). Increasing the number of COVID-19–related symptoms in combination
with a presenting fever ≥100.4°F increased the number of people who could be identified as having a COVID-19 infection. A total of 6894 patients were tested for COVID-19. Among these, 330 (4.8%) tested positive for active infection. Of these patients, 64
(19.4%) presented with a fever ≥100.4°F (≥38.0°C). Increasing the number of COVID-19–related symptoms in combination with a presenting fever ≥100.4°F increased the number of people who could be identified as having a COVID-19 infection. About a quarter of
patients who were tested positive for COVID-19 in our ED did not have a fever at presentation ≥100.4°F. |
|
Anti-SARS-CoV-2 antibody detection in healthcare
workers of two tertiary hospitals in Athens, Greece |
Vlachoyiannopoulos, P, Alexopoulos, et al |
Clinical Immunology |
Epidemiology| Épidémiologie Immunology | Immunologie |
This study used a validated assay to reliably detect anti-SARS-CoV-2 IgG antibodies in health workers and addresses
the impact of positivity in this population. 321 health workers, from two tertiary hospitals in Athens, Greece were recruited following ethical approval from the Boards of both hospitals. The period of sampling was from April 25th until May 10th, 2020. Participants
were stratified according to their relative risk of exposure to symptomatic SARS-CoV-2 carriers. Group A comprised of 57 participants and were considered as high risk as they have all potentially being in close contact with a symptomatic carrier, nevertheless
bearing all appropriate protective measures. Group B comprised of 140 participants and were considered as medium risk as they may have been on close contact with a symptomatic carrier. Group C comprised of 124 participants, considered as low risk and were
less likely to have been in contact with symptomatic carriers. Anti-SARS-CoV-2 antibodies were positive in 2/57 participants of group A (3.5%), 3/140 participants of group B (2.14%) and 2/124 participants of group C (1.61%). The observed differences were
not statistically significant (Fisher's exact test, p > 0.05). In total 7/321 samples were positive (2.18%) with an average positivity index of 1.42. The study reveals a relatively low percentage of exposure (even though there is no direct comparator) suggesting
that efficient protective measures were applied in both hospitals. |
|
Harmonizing Heterogeneous Endpoints in Coronavirus Disease 2019 Trials Without
Loss of Information |
von Cube, M, Grodd, et al |
Crit Care Med |
Healthcare Response | Réponse des soins de santé RCT |
The objectives are to provide hands-on statistical guidelines for harmonizing heterogeneous endpoints in coronavirus
disease 2019 clinical trials. A majority of coronavirus disease 2019 clinical trials collect information on mechanical ventilation, hospitalization, and death. We show how a stacked probability plot provides a detailed understanding of treatment effects on
the patients' course of hospital stay. It contributes to harmonizing multiple endpoints and differing lengths of follow-up both within and between trials. |
|
Characteristics of Pulmonary Auscultation in Patients with 2019 Novel Coronavirus in China |
Wang, B, Liu, et al |
Respiration |
Clinical data| Données cliniques |
This cross-sectional, observational study was conducted among patients with laboratory-confirmed COVID-19 at Wuhan
Red-Cross Hospital during the period from January 27, 2020, to February 12, 2020. The abnormal breath sounds in COVID-19 pneumonia had some consistent distributive characteristics and to some extent correlated with the radiologic features. Such evidence suggests
that electronic auscultation is useful to aid diagnosis and timely management of the disease. |
|
Waqas, M, Haider, et al |
Frontiers in Molecular Biosciences |
Vaccine Research| Recherche sur les vaccins |
Immunoinformatics approaches were employed to predict the antigenic epitopes against COVID-19 for the development of
a coronavirus peptide vaccine.The top 10 epitopes in SARS-CoV-2 structural proteins (spikes membrane, envelope and nucleocapsid) having antigenic sites were analyzed led by binding affinity and binding interactional analyses of top ranked predicted peptides
with the MHC-I HLA molecule. |
|
|
Ambulance Calls for Substance-Related Issues Before and After COVID-19 |
Weiner, SG, Cash, et al |
Prehosp Emerg Care |
Public Health response| Interventions de santé publique |
We tested the hypothesis that the pandemic has disproportionately affected individuals with substance use disorder
in Massachusetts.An interrupted time series analysis was performed to determine if there were changes in numbers of daily calls before a statewide declaration of emergency for COVID-19 (February 15-March 9, 2020), from the emergency declaration until a stay-at-home
advisory (March 10-March 22, 2020) and following the stay-at-home advisory (March 23-May 15, 2020). After an initial decline in substance-related ambulance calls following a statewide declaration of emergency, calls for substance use increased to pre-COVID-19
levels while those for other reasons remained at a lower rate. The results suggest that COVID-19 is disproportionately affecting individuals with substance use disorder. |
|
Yang, Q, Huo, et al |
Work |
Mental Health |
|
This study explores the impact of psychosocial stress caused by the COVID-19 epidemic on the work stress of returned
workers. Both perceived organizational support and perceived that social support can alleviate the impact of psychosocial stress on work stress. |
|
|
Bilateral, vertical supranuclear gaze palsy following unilateral midbrain infarct |
Yang, Y, Qidwai, et al |
BMJ Case Rep |
Long-Term Sequelae |
|
A 60-year-old man recently admitted for bipedal oedema, endocarditis and a persistently positive COVID-19 swab with
a history of anticoagulation on rivaroxaban for atrial fibrillation, transitional cell carcinoma, cerebral amyloid angiopathy, diabetes and hypertension presented with sudden onset diplopia and vertical gaze palsy. Vestibulo-ocular reflex was preserved. Simultaneously,
he developed a scotoma and sudden visual loss, and was found to have a right branch retinal artery occlusion. MRI head demonstrated a unilateral midbrain infarct. This case demonstrates a rare unilateral cause of bilateral supranuclear palsy which spares the
posterior commisure. The case also raises a question about the contribution of COVID-19 to the procoagulant status of the patient which already includes atrial fibrillation and endocarditis, and presents a complex treatment dilemma regarding anticoagulation. |
|
Yoshikawa, R, Abe, et al |
PLoS Negl Trop Dis |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here we describe a reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay that uses a portable
device for efficient detection of SARS-CoV-2. Direct RT-LAMP, without the RNA extraction step, was less sensitive than the standard RT-LAMP. |
|
|
Zabini, F, Albanese, et al |
International Journal of Environmental Research and Public Health |
Mental Health |
|
This study investigated the effectiveness of a simple and affordable remedy for improving psychological well-being,
based on audio-visual stimuli brought by a short computer video showing forest environments, with an urban video as a control .The virtual exposure to forest environments showed effective to reduce perceived anxiety levels in people forced by lockdown in limited
spaces and environmental deprivation. Although significant, the effects were observed only in the short term, highlighting the limitation of the virtual experiences. The reported effects might also represent a benchmark to disentangle the determinants of health
effects due to real forest experiences, for example, the inhalation of biogenic volatile organic compounds |
|
|
Zeng, Hao, Huang, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective study, consecutive COPD cases infected COVID-19 in East District of People's Hospital of Wuhan
University from Jan 11th 2020 to Mar 28th 2020 were included. Multivariate analysis indicated that age > 70 years (HR, 7.859, 95% CI: 1.376, 44.875; P = 0.020) and count of lymphocyte ≤ 0.8×109/L (HR, 27.429, 95% CI: 3.336, 225.530; P = 0.002) were risk factors
for death. |
|
|
Zhang, H, Shi, et al |
Psychiatry research |
Mental Health |
|
This study examined the prevalence of posttraumatic stress disorder (PTSD) symptoms and assessed mental illness via
an online survey among healthcare workers (HCWs) at the Central Hospital of Wuhan after the peak of the COVID-19 outbreak.Among the 642 HCWs, the prevalence of probable PTSD was 20.87%. Additionally, 88.88%, 82.09%, 100%, and 95.52% of HCWs with probable PTSD
reported varying degrees of anxiety, depression, somatic symptoms, and insomnia, respectively. |
|
|
Zhou, J, Zhang, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A cluster of patients with coronavirus disease 2019 (COVID-19) underwent repeated positive (RP) severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) RNA tests after they were discharged from the hospital. Using multivariate Cox regression analysis, risk factors associated with RP included a higher ratio of lymphocyte/white blood cell on admission (adjusted HR 7.038;
95% CI, 1.911–25.932; P = 0.0034), lower peak temperature during hospitalization (adjusted HR, 0.203; 95% CI, 0.093–0.443; P<0.0001), and the presence of comorbidities, particularly hypertension or chronic diseases in the respiratory system (adjusted HR, 3.883;
95% CI, 1.468–10.273; P = 0.0063). |
|
|
COVID-19 diagnosed by serological antibody test: A case report |
Zhou, M, Xiong, et al |
Signa Vitae |
Clinical data| Données cliniques |
A medical worker suspected of having COVID-19 in our hospital had fatigue and loss of appetite and pulmonary infection
indicated by CT, but the nucleic acid test was negative three times. Finally, she was confirmed to have COVID-19 by a serological antibody test. |
|
Zhu, W, Wei, et al |
BMC Health Serv Res |
Mental Health |
|
We aimed to investigate the prevalence of anxiety in Chinese medical staff and examine the relationship between social
support and anxiety. A cross-sectional study via internet survey was conducted from 15 March to 30 March, 2020. Coping styles had effects on the generaily positive association between social support and anxiety. |
|
|
COVID-19 infection prevalence in pediatric population: Etiology, clinical presentation,
and outcome |
Alsohime, F, Temsah, et al |
Journal of Infection and Public Health |
Review Literature| Revue de littérature |
|
|
Amigues, I, Pearlman, et al |
Expert Rev Clin Immunol |
Review Literature| Revue de littérature |
|
|
|
Review of the impact of COVID-19 on medical education system |
Anjankar, VP, Anjankar, et al |
International Journal of Current Research and Review |
Review Literature| Revue de littérature |
|
|
Systematic review of EEG findings in 617 patients diagnosed with COVID-19 |
Antony, AR, Haneef, et al |
Seizure |
Review Literature| Revue de littérature |
SR: searched Pubmed, Google Scholar, medRxiV/bioRxiV preprint servers. EEG abnormalities are common in COVID-19 related
encephalopathy and correlates with disease severity, preexisting neurological conditions including epilepsy and prolonged EEG monitoring. Frontal findings are frequent and have been proposed as a biomarker for COVID-19 encephalopathy. |
|
Azzi, Y, Bartash, et al |
Transplantation |
Review Literature| Revue de littérature |
|
|
|
The impact of oxidative stress damage induced by the environmental stressors on
COVID-19 |
Bakadia, BM, Boni, et al |
Life Sciences |
Review Literature| Revue de littérature |
|
|
Batra, K, Morgan, et al |
Signa Vitae |
Review Literature| Revue de littérature |
|
|
|
Bergman, BG, Kelly, et al |
Journal of substance abuse treatment |
Review Literature| Revue de littérature |
|
|
|
Bitsadze, VO, Sukontseva, et al |
Obstetrics, Gynecology and Reproduction |
Review Literature| Revue de littérature |
|
|
|
Cattel, F, Giordano, et al |
Virus research |
Review Literature| Revue de littérature |
|
|
|
Ceide, CF, López, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Review Literature| Revue de littérature |
|
|
|
Pharmacokinetic changes related to acute infection. Examples from the SARS-CoV-2
pandemic |
Chavant, A, Gautier-Veyret, et al |
Therapies |
Review Literature| Revue de littérature |
|
|
Cherian, V, Philip, et al |
Indian Journal of Community Health |
Review Literature| Revue de littérature |
|
|
|
Corse, T, Dayan, et al |
International Journal of Medical Sciences |
Review Literature| Revue de littérature |
|
|
|
Sewage surveillance system using urological wastewater: Key to COVID-19 monitoring? |
de Jong, FC, GeurtsvanKessel, et al |
Urologic Oncology: Seminars and Original Investigations |
Review Literature| Revue de littérature |
|
|
New kids on the block: taking stock of the recent cycle of climate activism |
de Moor, J, De Vydt, et al |
Social Movement Studies |
Review Literature| Revue de littérature |
|
|
De Sousa, FDB |
Recycling |
Review Literature| Revue de littérature |
|
|
|
Dotolo, S, Marabotti, et al |
Brief Bioinform |
Review Literature| Revue de littérature |
|
|
|
Chitosan-drug encapsulation as a potential candidate for COVID-19 drug delivery systems:
A review |
Ejeromedoghene, O, Oderinde, et al |
Journal of the Turkish Chemical Society, Section A: Chemistry |
Review Literature| Revue de littérature |
|
|
Gamage, KAA, Wijesuriya, et al |
Education Sciences |
Review Literature| Revue de littérature |
|
|
|
Anesthetic management of suspected or
confirmed COVID-19 patients a narrative review |
Gergess, A, Dagher, et al |
Journal Medical Libanais |
Review Literature| Revue de littérature |
|
|
Ghazali, WAHW, Nallaluthan, et al |
Gynecology and Minimally Invasive Therapy |
Review Literature| Revue de littérature |
|
|
|
Halushka, MK, Vander Heide, et al |
Cardiovascular Pathology |
Review Literature| Revue de littérature |
|
|
|
He, Shanshan, Han, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
|
|
|
Hosseini, A, Hashemi, et al |
Biomedicine and Pharmacotherapy |
Review Literature| Revue de littérature |
|
|
|
Hufsky, F, Lamkiewicz, et al |
Brief Bioinform |
Review Literature| Revue de littérature |
|
|
|
Antiviral treatment of covid-19: A clinical pharmacology narrative review |
Instiaty, Sri Darmayani, IGAAP, et al |
Medical Journal of Indonesia |
Review Literature| Revue de littérature |
|
|
Jafarzadeh, A, Nemati, et al |
Viral Immunol |
Review Literature| Revue de littérature |
|
|
|
Kalagani, B, Yeola, et al |
Journal of Datta Meghe Institute of Medical Sciences University |
Review Literature| Revue de littérature |
|
|
|
Can Nutrition Play a Role as a Stimulant for COVID 19 in Children? |
Kesavelu, D, Franklyn, et al |
Rev Recent Clin Trials |
Review Literature| Revue de littérature |
|
|
Langone, M, Petta, et al |
Environmental Pollution |
Review Literature| Revue de littérature |
|
|
|
Use of Chinese medicine in the prevention and treatment of COVID-19 in China and
Asia |
Law, S, Xu, et al |
Asian Education and Development Studies |
Review Literature| Revue de littérature |
|
|
Assessment model for evaluating the preparedness plan for COVID-19 in a tertiary
care hospital |
Llorente-Parrado, C, Mejon-Berges, et al |
Journal of Healthcare Quality Research |
Review Literature| Revue de littérature |
|
|
López Rod, AA, Martín, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Review Literature| Revue de littérature |
|
|
|
Maalouf, FT, Medawar, et al |
Journal of psychiatric research |
Review Literature| Revue de littérature |
|
|
|
Clinical applications of visual plasmonic colorimetric sensing |
Mauriz, E |
Sensors (Switzerland) |
Review Literature| Revue de littérature |
|
|
Merola, E, Pravadelli, et al |
Acta Gastro-Enterologica Belgica |
Review Literature| Revue de littérature |
SR-MA: searched MEDLINE, Scopus, Web of Science and the Cochrane Library, for studies reporting laboratory data about
COVID-19 patients, with last update on 25th March 2020. COVID-19-induced liver injury must not be ignored, as it is observed in one fifth of infected patients.
|
|
|
Statins and SARS-CoV-2 disease: Current concepts and possible benefits |
Minz, MM, Bansal, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Review Literature| Revue de littérature |
|
|
Moghnieh, R, Bizri, et al |
Journal Medical Libanais |
Review Literature| Revue de littérature |
|
|
|
Muhanna, D, Arnipalli, et al |
Biomedicines |
Review Literature| Revue de littérature |
|
|
|
Infection control in dentistry during COVID – 19 pandemic: what has changed? |
Patel, M |
Heliyon |
Review Literature| Revue de littérature |
|
|
COVID-19 and Major Organ Thromboembolism: Manifestations in Neurovascular
and Cardiovascular Systems |
Pillai, P, Joseph, et al |
Journal of Stroke and Cerebrovascular Diseases |
Review Literature| Revue de littérature |
|
|
The use of personal data in public policies against COVID-19 |
Portela, IM, Da Motta, et al |
Revista Juridica |
Review Literature| Revue de littérature |
|
|
Sakamoto, M, Sasaki, et al |
Progress in Disaster Science |
Review Literature| Revue de littérature |
|
|
|
A lasting impression: telemedicine in urogynecology during the coronavirus disease
2019 pandemic |
Serna-Gallegos, T, Ninivaggio, et al |
Curr Opin Obstet Gynecol |
Review Literature| Revue de littérature |
|
|
A Review of the Progress and Challenges of Developing a Vaccine for COVID-19 |
Sharma, O, Sultan, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
|
|
Sherin, F, Gomathy, et al |
International Journal of Current Research and Review |
Review Literature| Revue de littérature |
|
|
|
Laboratory diagnosis of novel corona virus (2019-nCoV)-present and the future |
Sidiq, Z, Hanif, et al |
Indian Journal of Tuberculosis |
Review Literature| Revue de littérature |
|
|
Singh, AK, Yeola, et al |
Journal of Datta Meghe Institute of Medical Sciences University |
Review Literature| Revue de littérature |
|
|
|
In Silico T Cell Epitope Identification for SARS-CoV-2: Progress and Perspectives |
Sohail, Muhammad Saqib, Ahmed, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
|
|
Surya, R |
Journal of Food Science Education |
Review Literature| Revue de littérature |
|
|
|
Varghese, PM, Tsolaki, et al |
Immunobiology |
Review Literature| Revue de littérature |
|
|
|
Wibisono, Y, Fadila, et al |
Polymers |
Review Literature| Revue de littérature |
|
|
|
A meta-analysis of the impact of COVID-19 on liver dysfunction |
Wu, ZH, Yang, et al |
Eur J Med Res |
Review Literature| Revue de littérature |
MA: computer and manual retrieval was used to search in Medline through PubMed, EMBASE and Web of Science. The mortality
and severity of COVID-19 patients are significantly associated with liver dysfunction. The non-survivors and severe COVID-19 patients have elevated serum AST levels than the survivors and non-severe COVID-19 patients. The results of this study form a basis
for better clinical liver management of patients with COVID-19. |
|
A systematic review and meta-analysis: the effect of active cancer treatment on
severity of COVID-19 |
Yekedüz, E, Utkan, et al |
European journal of cancer |
Review Literature| Revue de littérature |
SR-MA: MEDLINE database was searched on September 01, 2020. Chemotherapy increased the risk of death from COVID-19
in cancer patients. |
|
Yue, JL, Yan, et al |
Psychol Med |
Review Literature| Revue de littérature |
SR: PubMed, Web of Science, Embase, PsycINFO, WHO Global Research Database on infectious disease, and the preprint
server medRxiv were searched. |
|
|
Zahiri, Javad, Afsharinia, et al |
medRxiv |
Review Literature| Revue de littérature |
SR: searched PubMed database for articles published between the months of January and June 2020. Presence of GGO, consolidation,
bilateral lung involvement and peripheral distribution were the features reported in at least 83% of COVID-19 articles, while air bronchogram, multi-lobe involvement and linear opacity were the three potential COVID-19 specific CT imaging findings.
|
|
|
Zhao, J, Li, et al |
American Journal of Emergency Medicine |
Review Literature| Revue de littérature |
|
|
|
Zinzula, L |
Biochemical and biophysical research communications |
Review Literature| Revue de littérature |
|
|
|
Helminths and COVID-19 Co-Infections: A Neglected Critical Challenge |
Abdoli, A |
ACS Pharmacology and Translational Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Abi Saleh, W, Aoun-Bacha, et al |
Journal Medical Libanais |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Adlhoch, C, Pebody, et al |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 causes more mortality of men than women, why and how? Scientists view |
Ahmed, MSAM |
Indian Journal of Community Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Design thinking around Covid-19: Focusing on the garment workers of Bangladesh |
Ahmed, N, Rony, et al |
Interactions |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19: Oxidative Preconditioning as a Potential Therapeutic Approach |
Akki, R, Fath, et al |
ACS Chem Neurosci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: Group testing and digital technology “aarogya setu”-the need of the
hour |
Alagappan, U, Nagarajan, et al |
Indian Journal of Community Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Building the Next Generation of Nurses and Nursing Educators in a COVID-19 World |
Alexander, M |
Journal of Nursing Regulation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Saudi neurosurgery residency and covid-19: How are we coping? |
Almufarriji, RM, Alobaid, et al |
Neurosciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The equal danger of improper use of face mask and use of improper mask |
Aminnejad, R, Hormati, et al |
Archives of Clinical Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
An, N, Xianyu, et al |
Zhonghua Yu Fang Yi Xue Za Zhi |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Challenges in creating herd immunity to SARS-CoV-2 infection by mass vaccination |
Anderson, RoyM, Vegvari, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Andújar-Espinosa, R, Ros-Lucas, et al |
Medicina clinica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Antonelli, G, Stefani, et al |
Diagnostic microbiology and infectious disease |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Araj, GF, Beaini, et al |
Journal Medical Libanais |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Araujo, EJS, Melchán, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
What the COVID-19 Pandemic Has Reinforced: The Need for Accurate Data |
Arvisais-Anhalt, S, Lehmann, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Asabor, EN, Bunick, et al |
Journal of the American Academy of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
What to do as a gynecologic oncologist during the
COVID-19 pandemic? MEMAGO statement |
Atallah, D, Abdel Khalek, et al |
Journal Medical Libanais |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ayoub, E, Bahous, et al |
Journal Medical Libanais |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bačík, J, Tkáč, et al |
Applied Sciences (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bagley, SM, Hadland, et al |
Journal of substance abuse treatment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Banjar, HR, Alkhatabi, et al |
Int J Environ Res Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
How do the Covid-19 Prevention Measures Interact with Sustainable Development Goals? |
Beigi, Shima |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Emotional Burden Associated with COVID-19: Trust and Communication in Cancer
Care |
Bergerot, CD, Philip, et al |
Cancer Invest |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Berlin, I |
Heart |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bernatt, M, Zoboli, et al |
Yearbook of Antitrust and Regulatory Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A QuESt for speed: rapid qualitative evidence syntheses as a response to the COVID-19
pandemic |
Biesty, L, Meskell, et al |
Syst Rev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bitar, N, Kattan, et al |
Journal Medical Libanais |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bizri, AR, Moghnieh, et al |
Journal Medical Libanais |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
An innovative risk-scoring system of dental procedures and safety protocols in
the COVID-19 era |
Bizzoca, ME, Campisi, et al |
BMC Oral Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Black, S, Bloom, et al |
Seminars in immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bolourian, A, Mojtahedi, et al |
Archives of Medical Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bourgueil, Y, Falcoff, et al |
Rev Med Suisse |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Breton, M, Hudon, et al |
Rev Med Suisse |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
How COVID-19 inspired surgical residents to rethink educational programs |
Brian, R, Stock, et al |
American Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Brown, EA |
Health Equity |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Byrnes, ME, Varlamos, et al |
Dis Colon Rectum |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Insights from Pharmaceutical Biotechnology into Phenolic Biopharmaceuticals
against COVID-19 |
Cabral-Hipólito, N, Molina-Ramírez, et al |
Curr Pharm Biotechnol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
On the art of alchemy and unfolding desires: A conversation with maría magdalena campos-Pons |
Campos-Pons, M, Lewis-Cappellari, et al |
Theatre Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zika and novel coronavirus 2019 (2019-nCoV): Pandemic viruses sharing similarities |
Carpio-Orantes, L |
Archives of Clinical Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Castro, D, Robalinho, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Logistics flow optimization for advanced management of the crisis situation |
Chakir, I, El Khaili, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Chan, KW, Gentile, et al |
Eurasian Geography and Economics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The importance of robust research methodology in the era of COVID-19 and beyond |
Chaudhary, V |
Canadian Journal of Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Chen, YT, Yen, et al |
Int J Environ Res Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chowdhury, MAJ |
Bangladesh Medical Research Council bulletin |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Choy, Kay Weng |
The Lancet Microbe |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Point-of-care lung ultrasound in the assessment of patients with COVID-19: A tutorial |
Cid, X, Wang, et al |
Australasian Journal of Ultrasound in Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
33007477; What is the ‘new normal’ in surgical procedures in the era of COVID-19? |
Cimen, C, Keske, et al |
Clinical Microbiology and Infection |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cohidon, C, Senn, et al |
Rev Med Suisse |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Virtual Home Visits during the COVID-19 Pandemic: Social Workers’ Perspectives |
Cook, LL, Zschomler, et al |
Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cowie, BC, MacLachlan, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Dawood, S, Jaffar, et al |
Journal of Cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Immediate Impact of COVID-19 on Postsecondary Teaching and Learning |
Day, T, Chang, et al |
Professional Geographer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Concurrent Acute Ischemic Stroke and Non-aneurysmal Subarachnoid Hemorrhage in COVID-19 |
de Castillo, LLC, Ignacio, et al |
Can J Neurol Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
de Royston, MM, Lee, et al |
Phi Delta Kappan |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
de Souza, PMM, Gerson, et al |
PLoS Negl Trop Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Silver Lining in the Covid-19 Cloud: An Appraisal of Accelerated Prison
Decongestion in Kenya |
Deche, M, Bosire, et al |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Di Giorgio, A, Duca, et al |
ACS Central Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Dooley, JH, Bettin, et al |
Orthopedic Clinics of North America |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Delirium Assessment in Critically Ill Older Adults: Considerations During the COVID-19
Pandemic |
Duggan, MC, Van, et al |
Critical Care Clinics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19
and pregnancy: Lebanon preparedness within global response |
El Kak, F |
Journal Medical Libanais |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The effect of environmental pollution on immune evasion checkpoints of SARS-CoV-2 |
Engin, AB, Engin, et al |
Environmental toxicology and pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Fagell, PL |
Phi Delta Kappan |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Washington View: How the federal government can support schools: Words of wisdom
from Richard Riley |
Ferguson, M |
Phi Delta Kappan |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Impact of Covid-19
on the dietary habits of the Portuguese population |
Ferreira, I |
European Food and Feed Law Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Foley, R, Kaedbey, et al |
Current Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Radiological guidelines in patients with COVID-19 (Sechenov University experience) |
Fomin, VV, Ternovoy, et al |
Russian Electronic Journal of Radiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Consequences of the COVID-19/SARS-CoV-2 pandemic for gastroenterology in Germany |
Frieling, T |
Gastroenterologe |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gachabayov, M, Latifi, et al |
International Journal of Surgery Protocols |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Implementation science to address health disparities during the coronavirus pandemic |
Galaviz, KI, Breland, et al |
Health Equity |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gallus, S, Clavenna, et al |
European journal of internal medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Coronavirus and the carnivalesque: What speculative methods can tell us about Covid-19 |
Gatehouse, C |
Interactions |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Genzel, L, Adan, et al |
Current Biology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ghasemnejad-Berenji, M, Pashapour, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Informing children citizens efficiently to better engage them in the fight against
COVID-19 pandemic |
Ghia, JE, Gaulin, et al |
PLoS Negl Trop Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bulawayo operational observatory and mapping in response to COVID-19 social distancing
requirements |
Gibson, L, Sibanda, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Giustozzi, M, Vedovati, et al |
European journal of internal medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Gleicher, N |
Reprod Biol Endocrinol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Godlee, F |
The BMJ |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The BMJ interview: Chris Whitty, England's chief medical officer, on covid-19 |
Godlee, F, Looi, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The social-economic impact of COVID-19 pandemic: implications for potential
forest degradation |
Golar, G, Malik, et al |
Heliyon |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The effect of therapeutic plasma exchange on covid-19 therapy |
Göncüoğlu, C, Balli, et al |
Turkish Journal of Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gonzalez, A, Orozco-Aguilar, et al |
International Journal of Molecular Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
González, AAP, Contreras, et al |
Revista Cubana de Investigaciones Biomedicas |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Return-to-Play Guidelines for Athletes After COVID-19 Infection |
Greene, DN, Wu, et al |
JAMA Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Griñán-Rodríguez, E |
Revista Cubana de Investigaciones Biomedicas |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Grudin, J |
Interactions |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Early Spread of SARS-CoV-2 in the Icelandic Population. Reply |
Gudbjartsson, DF, Stefansson, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Medical social service officers and their contribution in COVID-19 pandemic |
Gupta, A, Sodhi, et al |
Indian Journal of Community Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Innovative point-of-care molecular diagnostic test for COVID-19 in India |
Gupta, Nivedita, Rana, et al |
The Lancet Microbe |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Is written informed consent ‘cast in iron’ even during a pandemic? |
Gupta, P, Naeem, et al |
Medical Journal Armed Forces India |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Habr, B, Dabar, et al |
Journal Medical Libanais |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Halpin, DMG, Criner, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Harman, S |
Ethics and International Affairs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Gig Workers with Disabilities: Opportunities, Challenges, and Regulatory Response |
Harpur, P, Blanck, et al |
J Occup Rehabil |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hashmi, N, Ullah, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Immunogenomic phases of COVID-19 and appropriate clinical management |
Haznedaroglu, IbrahimC |
The Lancet Microbe |
Commentary/Editorial| Commentaire/Éditorial |
|
|
He, Shanshan, Han, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Henderson, MK, Kozlakidis, et al |
Biopreserv Biobank |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Intolerable intersectional burdens: a COVID-19 research agenda for social and
cultural geographies |
Ho, ELE, Maddrell, et al |
Social and Cultural Geography |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Evolution of Colorectal Surgical Pathways in the Coronavirus Disease 2019 Pandemic |
Huddy, JR, Rasheed, et al |
Dis Colon Rectum |
Commentary/Editorial| Commentaire/Éditorial |
|
|
An ontology-based chatbot for crises management: use case coronavirus |
Hwerbi, Khouloud |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: GPs are told to be ready to deliver vaccine from next month |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Idrovo, AJ |
Int J Environ Res Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Jahedi, S, Yorke, et al |
Biology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Jamart, H, Van Maele, et al |
Rev Med Suisse |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Jeevananthan, C, Muhamad, et al |
BMJ Open |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Jesus, TS, Landry, et al |
Work |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A Survey on Contact Tracing: the Latest Advancements and Challenges |
Jiang, Ting, Chen, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Estimation of the basic reproduction rate (R0) of the novel coronavirus (COVID-19) |
Jie, S, Logeswaran, et al |
International Journal of Current Research and Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Jin, H, Reed, et al |
Journal of Allergy and Clinical Immunology: In Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Johnston, RM, Mohammed, et al |
Politics and Gender |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19: quick reflections from palliative care before the next epidemic |
Julià-Torras, J, de Iriarte Gay de Montellà, et al |
Medicina clinica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: Hungary's pandemic response may have been worse than the virus |
Karáth, K |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kinch, MS |
ACS Pharmacology and Translational Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Koay, HF, Fulford, et al |
J Exp Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Covid-19 pandemic: Collective action and European public policy under stress |
Kovac, M |
Central European Journal of Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lai, L, Wittbold, et al |
Healthcare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33094581; The changing landscape of hepatology and gastroenterology |
Lanthier, N, Vanuytsel, et al |
Acta Gastro-Enterologica Belgica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Funding pandemic prevention: Proposal for a meat and wild animal tax |
Larnder-Besner, M, Tremblay-Gravel, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rapid Implementation of Virtual Health in a Pediatric Neurology Practice During COVID-19 |
Lee, J, Schrader, et al |
Can J Neurol Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lench, DH, Simpson, et al |
Brain Stimulation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Liang, N, Li, et al |
Am J Chin Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Looi, JC, Anderson, et al |
Australas Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lottridge, D |
Interactions |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lyons, N, Lăzăroiu, et al |
Geopolitics, History, and International Relations |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ma, A, Kase, et al |
Journal of Stroke and Cerebrovascular Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Oil spill + COVID-19: A disastrous year for Brazilian seagrass conservation |
Magalhães, KM, Barros, et al |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Maiti, BK |
ACS Pharmacology and Translational Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Makatsariya, AD, Di Renzo, et al |
Obstetrics, Gynecology and Reproduction |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32971311; SARS-CoV-2 Pandemic Impacts on NASA Ground Operations to Protect ISS
Astronauts |
Makedonas, G, Mehta, et al |
Journal of Allergy and Clinical Immunology: In Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Malone, DM, Day, et al |
Ethics and International Affairs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mantskava, M, Akhvlediani, et al |
Series on Biomechanics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lessons Learned from a COVID-19 Biohazard Spill During Swabbing at a Quarantine Facility |
Mayer, O, Pfundt, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mc Gee, U, Sanders, et al |
Phys Sportsmed |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Impact of SARS-CoV-2 (COVID-19) on pregnancy: a systematic review and meta-analysis
protocol |
Medeiros, KS, Sarmento, et al |
BMJ Open |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Diagnosis of acute myocardial infarction in the time of the COVID-19 pandemic |
Mele, M, Casavecchia, et al |
Eur Heart J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
[Consequences, visibility and denial of a pandemic: processes of self-care] |
Menéndez, EL |
Salud Colect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
"I teach the audience how to watch my shows": An interview with kristina wong |
Metzger, S, Wong, et al |
Theatre Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
"We're in for a future of provocateurs": An interview with David Yee on Asian Canadian
Theatre |
Metzger, S, Yee, et al |
Theatre Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A model for rapid emergency department expansion for the COVID-19 pandemic |
Miller, NM, Jones, et al |
American Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Molenberghs, G, Buyse, et al |
Contemporary Clinical Trials |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Montanari, F, Arayess, et al |
European Food and Feed Law Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Moorthy, V |
Global Spine J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33091523; COVID-19 and arterial thrombosis: A potentially fatal combination |
Moroni, F, Baldetti, et al |
International journal of cardiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nexus planning as a pathway towards sustainable environmental and human health
post Covid-19 |
Nhamo, L, Ndlela, et al |
Environmental research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Norris, K, Gonzalez, et al |
EClinicalMedicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Obergassel, W, Hermwille, et al |
Climate Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The implications of covid-19 in radiation oncology in the United States |
Odei, B, Quick, et al |
Current Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Virtual ARCP assessment and trainee feedback meetings: facilitating the best experience
and practice |
Oeppen, RS, Rutherford, et al |
British Journal of Oral and Maxillofacial Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Onigbinde, OA, Ajagbe, et al |
Morphologie |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Processing T of the
digital information in times of COVID-19: The value of proximity media |
Ordóñez, K, Ramón, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A multiple therapy hypothesis for treatment of COVID-19 patients |
Oscar, TP |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The care economy and the state in Africa’s Covid-19 responses |
Ossome, L |
Canadian Journal of Development Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ozenen, G |
Work |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Paladines, F, Valarezo, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Papageorgiou, Maria, Silva Nogueira Melo, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Usefulness of the antigen for diagnosing SARS-CoV-2 infection in patients with
and without symptoms |
Parada-Ricart, E, Gomez-Bertomeu, et al |
Enfermedades infecciosas y microbiologia clinica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Supplying synthetic opioids during a pandemic: An early look at North America |
Pardo, B |
International Journal of Drug Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
33039648; Ten Rules for Implementation of a Telemedicine Program to Care for Patients
with Asthma |
Persaud, YK, Portnoy, et al |
Journal of Allergy and Clinical Immunology: In Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Perumal, V, Curran, et al |
The Ulster medical journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Return-to-Play Guidelines for Athletes After COVID-19 Infection-Reply |
Phelan, D, Kim, et al |
JAMA Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Meaningful Big Data Integration for a Global COVID-19 Strategy |
Pita Costa, J, Grobelnik, et al |
IEEE Computational Intelligence Magazine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pittinsky, TL |
Phi Delta Kappan |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Plotz, B, Castillo, et al |
Rheumatology (Oxford) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Polcin, DL, Mahoney, et al |
International Journal of Drug Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Porras, JL, Mallipudi, et al |
World Neurosurgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Comics as Covid-19 response: Visualizing the experience of videoconferencing with aging relatives |
Priego, E, Wilkins, et al |
Interactions |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rabiller, G, Cordoba, et al |
Revista Espanola de Medicina Nuclear e Imagen Molecular |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rajkumar, RP |
Sleep medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32992059; COVID Contingencies: Resource Rationing on a Global Scale |
Ramey, WL, Hurlbert, et al |
World Neurosurgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Impact of lockdown 1.0-4.0 on spread of covid-19 pandemic in india |
Ranjan, A, Ayub, et al |
Indian Journal of Community Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
4/6 Majoration de troubles anxieux pendant le confinement en
Ehpad |
Retailleau, B |
Soins Aides - Soignantes |
Commentary/Editorial| Commentaire/Éditorial |
|
|
What obstetricians should know about obstetric anesthesia during the COVID-19
pandemic |
Ring, LE, Martinez, et al |
Seminars in perinatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rogers, LC, Snyder, et al |
J Am Podiatr Med Assoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The government of
Spain and the coronavirus: Rally round the flag and its effects |
Rubia, AG, Antonia Martínez Rodríguez, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Samanci, S, Didem Atalay, et al |
Journal of Air Transport Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Return-to-Play Guidelines for Athletes After COVID-19 Infection |
Santos-Ferreira, D, Tomás, et al |
JAMA Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A pragmatic proposal for triaging DXA testing during the COVID-19 global pandemic |
Sapkota, HR, Nune, et al |
Osteoporos Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sarkis, R, Hassan, et al |
Journal Medical Libanais |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Schöbel, C, Werther, et al |
Journal of Thoracic Disease |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
America, consciousness, COVID-19, climate change, and migration |
Schwartz, SA |
Explore |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Scientist, N |
New Scientist |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Uncertain evolution of untreated coronary syndromes during covid-19 pandemic |
Seco Vasco, JR, Curado Castano, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sen Gupta, PS, Rana, et al |
ACS Pharmacology and Translational Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sharma, M, Dhillon, et al |
Indian Journal of Orthopaedics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
SARS-CoV-2 infection in children and kawasaki disease. What is the relationship? |
Shirvani, F, Mosallanejad, et al |
Archives of Clinical Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Superimposed threats to population health from tropical cyclones in the prevaccine
era of COVID-19 |
Shultz, JamesM, Kossin, et al |
The Lancet Planetary Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sexual violence against women in Bangladesh during the COVID-19 pandemic |
Sifat, RI |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tourism 5.0: A contribution
to the identification of specialized niches from context awareness |
Silva, MIL, Rojas, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Graphene-based optical sensors for the pre-vention of SARS-CoV-2 viral dissemination |
Simone, Giuseppina |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Informed consent, duty of disclosure and chiropractic: where are we? |
Simpson, JK, Innes, et al |
Chiropr Man Therap |
Commentary/Editorial| Commentaire/Éditorial |
|
|
‘Quixotic’ tourism? Safety, ease, and heritage in post-COVID world tourism |
Singh, S |
Journal of Heritage Tourism |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID 19 pandemic: Lesson learned by South Korea and its application with India’s
perspective |
Sinha, S, Chandra, et al |
Indian Journal of Community Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Achieving Health Equity: Examining Telehealth in Response to a Pandemic |
Smith, S, Raskin, et al |
Journal for Nurse Practitioners |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Spatial variation in socio-ecological vulnerability to Covid-19 in the contiguous
United States |
Snyder, BF, Parks, et al |
Health and Place |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Masks in Melbourne: an inpatient mental health unit's COVID-19 experience |
Soh, KC, Khanna, et al |
Australas Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Soto, CMD, Torres, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Towards unified and real-time analyses of outbreaks at country-level during pandemics |
Soubeyrand, S, Demongeot, et al |
One Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Souza, ASR, Souza, et al |
Revista Brasileira de Saude Materno Infantil |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Steed, A, Ortega, et al |
Interactions |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Stella, M |
Systems |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Reflecting on collaborations with charities in the time of Covid-19 |
Strohmayer, A |
Interactions |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Improving
mental health and reducing suicide risk: How GPs can help during the COVID-19 pandemic |
Su, WM, Stone, et al |
Medicine Today |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Biosurfactants and anti-inflammatory activity: A potential new approach towards
COVID-19 |
Subramaniam, MD, Venkatesan, et al |
Current Opinion in Environmental Science and Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Swift, W |
In practice |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Tavassoly, O, Safavi, et al |
ACS Chem Neurosci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Thomopoulos, C, Michalopoulou, et al |
J Hypertens |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pediatric anesthesia techniques during the COVID-19 pandemic |
Trujillo, A, Arango, et al |
Signa Vitae |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 Has Brought Back the Necessity of the Welfare State: The Greek Case |
Tzagkarakis, Stylianos, Pappas, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
[Principles of prevention and precaution : some guidelines for understanding them] |
Vernez, D, Cornuz, et al |
Rev Med Suisse |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Four ways Trump has meddled in pandemic science - and why it matters |
Viglione, G |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Vijayasekaran, D, Kalpana, et al |
Indian J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lessons from a pandemic: Do not force your patients into the bed of Procrustes! |
Voiosu, T, Voiosu, et al |
J Eval Clin Pract |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Walters, SM, Seal, et al |
Health Behavior and Policy Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mental health response for children and adolescents during the COVID-19 outbreak
in China |
Wang, J, Li, et al |
Psychiatry research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wangge, G |
Medical Journal of Indonesia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 Necessitates a Commitment to Social Mission in Medical Education |
Westfall, M, Westfall, et al |
Acad Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
On physical and social distancing: Reflections on moving just about everything online amid
Covid-19 |
Wiberg, M |
Interactions |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32965663; Delaying radical prostatectomy, cancer screening, and care due to
COVID-19 |
Wright, K, Moul, et al |
ONCOLOGY (United States) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Practice Patterns of Colorectal Surgery During the COVID-19 Pandemic |
Wu, XR, Zhang, et al |
Dis Colon Rectum |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Leisure meets health: important intersections and alternative discourses |
Young, J, Maxwell, et al |
Annals of Leisure Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zhu, Y, Ali, et al |
Resources, Conservation and Recycling |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
|
Commentary/Editorial| Commentaire/Éditorial |
|
Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.*
Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.
Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers.
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Séquelles à long terme:
Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.
Santé mentale:
Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées
à la pandémie.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives