Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-11-04
Good afternoon,
There are 776 citations in today’s scan. 451 were considered primary research or review literature.
Highlights today include:
CANADA
·
Vijh et al. conducted a cross-sectional serological survey of LTC residents and staff members at 2 adult LTC facilities located in the
Metro Vancouver area, British Columbia that experienced COVID-19 outbreaks in order to evaluate current clinical COVID-19 case definitions. Myalgias, headaches, loss of appetite and having 3 or more negative nasopharyngeal swabs were significantly associated
with seropositivity among individuals with a negative or no previous diagnostic test.
·
Jerome et al examines physician knowledge of the ABTraceTogether smartphone app and practice
patterns in relation to the app. ABTraceTogether smartphone app was released in Alberta, Canada in may, 2020. 96% of participants were aware of the app but only 27% had recommended the app to patients. The most common reason provided for not downloading or
recommending the app was that participants had security concerns about the app.
IPAC
·
Uema et al.
examined the effectiveness of visible light-responsive photocatalyst on the inactivation of SARS-CoV-2 under different temperatures and exposure durations. The viral activation on the photocatalyst-coated glass slides decreased after exposure to visible
light irradiation for 6h at 20 degrees C. Immunoblotting and electron microscopic analyses showed reduced spike protein amounts on the viral surface after the photocatalyst treatment.
·
Inagaki et al.
evaluated the inactivating effect of ozone water against SARS-CoV-2 by its concentration and exposure time. The reduction rates of virus titer after 5 sec treatment with ozone concentrations of 1, 4, 7, and 10 mg/L were 81.4%, 93.2%, 96.6, and 96.6%,
respectively. No further decrease in virus titer was observed by the extended exposure time over 5 sec. High-concentration ozone water was considered to be effective in promptly inactivating the SARS-CoV-2 virus.
·
Gerlach et al
evaluated single components of disinfectants and household cleaning agents against SARS-CoV-2 on various surfaces. They find that SARS-CoV-2 can be inactivated effectively by 70% EtOH, 70% IPA, 0.1% H2O2 and 0.1% SLS within 60 s of exposure on various
surfaces.
IMMUNOLOGY
·
Muecksch et al
conducted a longitudinal analysis of COVID-19 convalescent cases. Findings reveal that neutralizing antibody levels decline rapidly early after infection and the median neutralization titer decreased by ~45% per month. Some clinical serological assay
platforms give quantitative outputs that predict neutralizing antibody titer, but some have diagnostic sensitivity that deteriorates with time post infection.
EPIDEMIOLOGY
·
Li et al.
aimed to determine the impact of SARS-CoV-2 infection on male fertility. This is a single-center, hospital-based observational study that included autopsied testicular and epididymal specimens of deceased COVID-19 male patients (n=6) and recruited recovering
COVID-19 inpatients (n=23) with an equal number of age-matched controls, respectively. We performed histopathological examinations on testicular and epididymal specimens, and also performed TUNEL assay and immunohistochemistry. Impairment of spermatogenesis
was observed in COVID-19 patients, which could be partially explained as a result of an elevated immune response in testis. Additionally, autoimmune orchitis occurred in some COVID-19 patients.
·
Forbes et al.
investigated whether the risk of infection with SARS-CoV-2 and severe outcomes differed between adults living with and without children. Among adults ≤65 years, living with children 0-11 years was not associated with increased risks of recorded SARS-CoV-2
infection, COVID-19 related hospital or ICU admission but was associated with reduced risk of COVID-19 death. Living with children aged 12-18 years was associated with a small increased risk of recorded SARS-CoV-2 infection. Among adults >65 years, there was
no association between living with children and outcomes related to SARS-CoV-2. The authors observed no consistent changes in risk following school closure.
·
Abu Esba et al. conducted a prospective cohort study to assess the association of acute and chronic use of nonsteroidal
anti-inflammatory drugs (NSAIDs) with worse COVID-19 outcomes. The authors found that acute or chronic use of ibuprofen and other NSAIDs was not associated with worse COVID-19 disease outcomes.
DIAGNOSTICS
·
Li et al.
constructed a machine-learning model based on ocular surface features and proposed a new screening method for COVID-19. The performance of detecting COVID-19 patients in the retrospective study has achieved an AUC of 0.999, with a sensitivity of 0.982,
and a specificity of 0.978. in the prospective study, the model achieved an AUC of 0.980, a sensitivity of 0.77, and a specificity of 0.973. According to the authors, this deep learning method based on eye-region images demonstrates high accuracy to distinguish
COVID-19 patients.
PUBLIC HEALTH RESPONSE
·
Helsingen et al.
aimed to compare peoples’ attitudes towards authorities and control measures, and perceived impact of the pandemic and implemented control measures on life in Norway and Sweden. Sweden had more trust in the authorities, while Norwegians reported a more
negative lifestyle during the pandemic.
·
Takashima et al.
examined the perceptions of community-dwelling older adults (average 78 yoa) about how COVID-19 restricted their daily lives via focus-group interviews. Generated themes were: “fear of infection and public, watchful eyes,” “consistency in daily personal
life,” “pain from reducing my social life,” “readiness to endure a restricted life,” “awareness of positive changes in myself,” and “concern for a languishing society.” Everyone's social lives were reduced, which over the long term can lead to a lost sense
of purpose in life.
·
Gollwitzer at al
use the geotracking data of 15 million smartphones per day, we found that US counties that voted for Donald Trump (Republican) over Hillary Clinton (Democrat) in the 2016 presidential election exhibited 14% less physical distancing between March and
May 2020. Partisanship was more strongly associated with physical distancing than numerous other factors, including counties’ COVID-19 cases, population density, median income, and racial and age demographics. Contrary to our predictions, the observed partisan
gap strengthened over time and remained when stay-at-home orders were active.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura
Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert, Clifford Clark
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics /
Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance,
Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, Immunologie,
économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
|
PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Side chain similarity comparisons for integrated drug repositioning and potential toxicity assessments in epidemic response scenarios: The case for COVID-19 |
Ab Ghani, NS, Emrizal, et al |
Computational and Structural Biotechnology Journal |
Coronavirology| Coronavirologie |
In this work, the three-dimensional arrangements of amino acid side chains in known drug binding sites (substructures)
were used to search for similarly arranged sites in SARS-CoV-2 protein structures in the Protein Data Bank for the potential repositioning of approved compounds. We were able to identify 22 target sites for the repositioning of 16 approved drug compounds as
potential therapeutics for COVID-19.Using the same approach, we were also able to investigate the potentially promiscuous binding of the 16 compounds to off-target sites that could be implicated in toxicity and side effects that had not been provided by any
previous studies. |
|
Abbas, S, Rafique, et al |
Pakistan Journal of Medical Sciences |
Clinical data| Données cliniques |
To evaluate the oscillation of laboratory parameters among patients infected with COVID-19 at Tertiary Care Institute, Rawalpindi from 01 March 2020 to
20 May 2020. A total of 392 patients enrolled in the study with age range 9-45 and mean 33.22±7.98 years. A total of 8 (2%) patients were females and 384(98%) males. 296(75.5%) did not have a cough whereas 96(24.5%) presented with the trait. 296 (75.5%) patients
did not have associated fever whereas 96(24.5%) manifested with fever. Chest x-ray had a bilateral patch in 96 (24.5%) patients only. Ferritin was raised in 96 (24.5%) patients however were recorded within normal limits in 296(75.5%) patients. Coagulation
Profile was deranged in 64(16.3%) patients whereas was within range in 328(83.7%) patients. Serum Bilirubin, Serum Alkaline phosphatases, Serum Albumin, Serum Urea, Serum Potassium were essentially in typical tolls in 392(100%) patients. However Serum Alanine
Aminotransferase was raised in 32(8.2%), Serum C reactive Protein was elevated in 48(12.2%). An exaggerated values of serum creatinine and serum sodium were noticed in 24(6.1%) and 16(4.1%) respectively. |
|
|
Non-ICU Nurses on the Surge in Dealing with COVID ICU Patients:
A Cross-Sectional Survey |
Abdul Rahim, Komal, Yousaf, et al |
SSRN- Lancet prepublication |
Healthcare Response | Réponse des soins de santé |
An online cross-sectional survey was administered in a tertiary care hospital in Pakistan to all the nurses dealing with COVID patients who were on ventilator
(see appendix 1). A total of 60 nurses participated in the study with a diverse group including Registered Nurses (RNs), Nursing Interns (NIs), and Trainee Nurse Interns (TNIs). |
|
Methodology for the Triage of Urologic Surgical Cases in the Setting of
a Pandemic |
Aboumohamed, Ahmed, Gottlieb, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
The COVID-19 pandemic forced our healthcare system in the Bronx, New York to cancel nearly all surgeries. With the possible second wave approaching, we
developed a framework for the prioritization of Urologic surgeries that can be used as a model for those experiencing surges elsewhere. Our disease-specific approach to surgical rescheduling offers appropriate guidance for triaging Urologic surgeries. Our
system can provide guidance to other institutions as COVID-19 surges in different regions and with the growing possibility of a second wave. |
|
Elsberg Syndrome in the Setting of Asymptomatic SARS-CoV-2 infection: Case
Report |
Abrams, RoryM, Desland, et al |
Research Square prepub |
Clinical data| Données cliniques |
We report here, to our knowledge, the first case of suspected COVID-19 associated Elsberg syndrome, which may help to shed light on ways in which to approach
diagnostic and treatment options in COVID-19 patients presenting with uncommon neurological and autonomic manifestations. |
|
Abu Esba, LC, Alqahtani, et al |
Infect Dis Ther |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of our study was to assess the association of acute and chronic use of nonsteroidal anti-inflammatory drugs
(NSAIDs) with worse COVID-19 outcomes. We did a prospective cohort study between April 12 and June 1, 2020. Acute use of ibuprofen was not associated with a greater risk of mortality relative to non-use (adjusted hazard ratio HR] 0.632 95% CI 0.073-5.441;
P = 0.6758]). Chronic NSAID use was also not associated with a greater risk of mortality (adjusted HR 0.492 95% CI 0.178-1.362; P = 0.1721]). Acute ibuprofen use was not associated with a higher risk of admission compared to non-NSAID users (adjusted odds
ratio OR 1.271; 95% CI 0.548-2.953). NSAID users did not have a significantly longer time to clinical improvement or length of stay. |
|
|
Adegbola, Peter Ifeoluwa, Semire, et al |
Research Square prepub |
Therapeutics| Thérapeutique |
The antiviral activity of many plants including Azadirachta indica, Xylopia aethiopica and Allium cepa has been reported.
our study investigated the inhibitory potentials of Azadirachta indica and Xylopia aethiopica isolates against SARS-CoV-2 viral accessory proteins and the host serine protease. Molecular docking analysis was performed with Auto Dock Vina 1.5.6 and visualization
of the interaction between the ligands and protein was done with discovery studio 2019. The ADMET prediction of pharmacokinetics and toxicity properties of the ligands was obtained using vNN Web Server. Overall, twenty-three of the forty-seven isolates showed
good binding affinity comparable with dexamethasone that was used as reference drug. This study provides an insight into potential inhibitors and novel drug candidates for SARS-CoV-2. |
|
|
Adhena, G, Hidru, et al |
Infection and Drug Resistance |
Public Health response| Interventions de santé publique |
Therefore, this study aimed to assess the knowledge, attitude, and practice of high-risk age groups to coronavirus
disease-19 prevention and control in Korem district, Tigray, Ethiopia. Overall, about 37.7%, 43.4%, and 52.5% of participants had poor knowledge, negative attitude, and poor practice towards coronavirus disease-19 prevention and control, respectively. Being
elder (≥ 80) years, with no formal education, and having low-income status were among the significantly associated factors. About 76.1% of the respondents did not use hand-rub-based alcohol or sanitizer, and 88.8% did not use any mask in crowding area. |
|
|
Al Ghafri, T, Al Ajmi, et al |
Journal of primary care & community health |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to explore the experiences and perceptions of health care workers (HCWs) in primary
health care in the management of COVID-19 with respect to medical response experiences, socio-cultural and religious reforms, psychological impressions, and lessons learned. Three themes emerged related to the medical response experiences, including the rapid
re-structuring of the PHC services, use of technology and challenges of working on COVID-19. Perceptions on the socio-cultural and religious reforms included changes in social and religious norms, and anticipated gaps in accessing health care among the vulnerable
groups (elderly, expatriates, and individuals with low economic status). Perceptions on psychological disturbances were themed as consequences of social distancing, management of dead bodies, exhaustion among the health care workers, and risk of exposure.
Finally, lessons learned were centered around building on the existing epidemiological and public health capacities, improving access to health care and overcoming resistance to change. Most participants labelled their experience in COVID-19 as an “experience
of wisdom” in which learning was a continuous process. |
|
|
Plastic
surgery and COVID-19 in the GCC: Fears, lessons learned, and the plan for the future |
Al Saud, NA, Alanazi, et al |
Plastic and Reconstructive Surgery - Global Open |
Healthcare Response | Réponse des soins de santé |
We aimed to investigate the effect of these national directive instructions on the surgeons and to review their strategies
for adapting their practices during this new pandemic. Methods: A cross-sectional descriptive study was conducted using an online questionnaire. It was constructed to assess the attitudes and practices of plastic surgeons in the Gulf Cooperation Council countries
during the COVID-19 lockdown. Results: Over two-thirds (69.5%) indicated that the pandemic had affected their practice. Surgeons in private practices were significantly affected (P < 0.001) compared with those in the public sector. Only 39% of respondents
mentioned COVID-19 testing as part of their post-pandemic surgical protocol. |
|
Albert, E, Bracho, et al |
J Med Virol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The magnitude of nasopharyngeal (NP) SARS-CoV-2 load either at hospital admission or during the course of hospitalization
has been directly associated with mortality of COVID-19 patients. This article is protected by copyright. All rights reserved. |
|
|
Alemany-Arrebola, I, Rojas-Ruiz, et al |
Frontiers in Psychology |
Mental Health |
|
This research analyzes the relationship between perceived self-efficacy in the confinement period and the level of
trait anxiety (TA) and state anxiety (SA) during COVID-19. Four hundred twenty-seven students from the University of Granada (Spain) participated in this study. The results indicated that there was an inversely proportional relationship between anxiety and
self-efficacy; men showed the highest perception of self-efficacy, while women had higher scores in TA and SA; the latter was accentuated in cases when a relative died. To conclude, students who show a higher level of anxiety (TA and SA) express more negative
emotions and also perceive themselves with less academic self-efficacy. Therefore, a stressful situation (pandemic and confinement) together with a critical event (illness and death of a relative/friend due to COVID-19) increases anxiety levels and influences
the perception of academic self-efficacy. |
|
|
AlGhamdi, NA, Alsuwat, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie |
The study aims to investigate protein-protein interactions (PPI) of hACE2 with SARS-CoV-2 RBD between wild and variants
to detect the most influential interaction. Variants of hACE2 were retrieved from NCBI and subjected to determine the most pathogenic nsSNPs. Probability of PPIs determines the binding affinity of hACE2 genetic variants with RBD was investigated. Composition
variations at the hACE2 and RBD were processed for PatchDock and refined by FireDock for the PPIs. Twelve nsSNPs were identified as the top pathogenic from SNPs (n = 7489) in hACE2 using eight bioinformatics tools. Eight RBD variants were complexed with 12
nSNPS of hACE2, and the global energy scores (Kcal/mol) were calculated and classified as very weak (-3.93 to -18.43), weak (-18.42 to -32.94), moderate (-32.94 to -47.44), strong (-47.44 to -61.95) and very strong (-61.95 to -76.46) zones. Seven composition
variants in the very strong zone G726R-G476S; R768W-V367F; Y252N-V483A; Y252N-V367F; G726R-V367F; N720D-V367F and N720D-F486L], and three in very weak P263S-S383C; RBD-H378R; G726R-A348T] are significantly (p < 0.00001) varied for global energy score. Zonation
of the five zones was established based on the scores to differentiate the effect of hACE2 and RBD variants on the binding affinity. Moreover, our findings support that the combination of hACE2 and RBD is key players for the risk of infection that should be
done by further laboratory studies. |
|
|
Ali, S, Luxmi, et al |
Trials |
RCT |
The aim of this trial is to investigate the safety and clinical efficacy of passive immunization therapy through Hyperimmune
anti-COVID-19 Intravenous Immunoglobulin (C-IVIG: 5% liquid formulation), on severe and critically ill patients with COVID-19. This is a phase I/II single centre, randomised controlled, single-blinded, superiority trial, through parallel-group design with
sequential assignment. This trial was registered at ClinicalTrials.gov, NCT04521309. |
|
|
The detection of Howell-Jolly body-like inclusions
in a case of coronavirus disease-2019 (COVID-19) |
Alisjahbana, B, Huang, et al |
Blood Res |
Clinical data| Données cliniques |
This is a case-report of a 29-year old woman with SARS-CoV-2 infection. Her peripheral blood film showed Howell–Jolly
body-like inclusions in both neutrophils and eosinophils along with atypical lymphocytes with an eccentric nucleus, deep blue-stained cytoplasm, and visible nucleoli. |
|
Aliyu, S, Norful, et al |
American Journal of Infection Control |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to obtain various clinical staff perspectives about preparedness to meet the demands
for care during the early phase of the SARS-CoV-2 (COVID-19) pandemic. Fifty-five clinical staff participated in the study. Three themes emerged from the data (1) Risk assessment and planning: “The powder keg,” (2) Innovative evolution of roles and responsibilities,
and (3) Pandemic response and capacity. In the early phases of the pandemic, participants reported varying levels of risks for dying. However, most participants adapted to practice changes and became innovative in their roles over time. Hierarchies were less
relevant during care delivery, whereas team collaboration became crucial in managing workforce capacity. |
|
|
Mortality tracker - the COVID-19 case for real time web APIs as epidemiology
commons |
Almeida, JS, Shiels, et al |
Bioinformatics |
Epidemiology| Épidémiologie |
Describes the development of Mortality Tracker, an in-browser application for data wrangling, analysis, dissemination
and visualization of public time series of mortality in the United States. Comparisons are performed between 2020 real time values with observations from the same week in the previous 5 years, and by enabling the extraction of temporal snapshots of mortality
series that facilitate modeling the interdependence between its causes. |
|
COVID-19 spread in Saudi Arabia: Modeling, simulation and analysis |
Alrasheed, H, Althnian, et al |
International Journal of Environmental Research and Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
We propose a simulation model for the spread of Coronavirus Disease 2019 (COVID-19) in Saudi Arabia using a network-based
epidemic model. The proposed model was used to evaluate the effectiveness of the control measures employed by the Saudi government. Our results also show that the closure of schools and mosques had the maximum impact on delaying the epidemic peak and slowing
down the infection rate. |
|
Rapid transfer of knowledge for multiple sclerosis clinical care during COVID-19:
ECHO MS |
Alschuler, KN, von Geldern, et al |
Multiple Sclerosis and Related Disorders |
Healthcare Response | Réponse des soins de santé |
Participant providers in the ECHO MS COVID19 project overwhelmingly indicated that the program improved their knowledge,
attitude, and skills for providing healthcare for people with MS during the COVID-19 pandemic. |
|
33084795; Abdominal symptoms as initial manifestation of COVID-19: a
case series |
Amaral, LTW, Brito, et al |
Einstein (Sao Paulo, Brazil) |
Clinical data| Données cliniques |
We report a case series of ten patients who came to the emergency department of our institution with a chief gastrointestinal
complaint, and were initially submitted to an abdominal computed tomography as the first investigation. Although most of the patients did not have significant changes in the abdominal images, most reported patients had pulmonary findings visualized at the
lung bases, which were later designated as typical COVID-19 pulmonary findings on chest computed tomography. Only one patient had atypical COVID-19 lung changes on chest computed tomography. All patients had a positive real-time polymerase chain reaction for
COVID-19. It is imperative to alert radiologists, especially abdominal radiologists, with the possibility of COVID-19 isolated gastrointestinal symptoms. Besides, it must become a habit to radiologists to assess the pulmonary basis on abdominal scans, a site
commonly affected by the new coronavirus. |
|
Amit Aharon, A, Ruban, et al |
Nursing outlook |
Healthcare Response | Réponse des soins de santé |
This study examines nurses’ knowledge and strategies of information credibility sourcing. Nurses' knowledge of COVID-19
preventative behaviors was significantly higher than that of laypersons; however, there was no difference in science-based knowledge of COVID-19. In contrast to laypersons, nurses in this study were better able to discern the credibility of health-related
information about COVID-19 than laypersons. Yet they rarely used scientific criteria in evaluating conflicting information. |
|
|
Knowledge of dental academics about the COVID-19 pandemic: a multi-country online
survey |
Ammar, N, Aly, et al |
BMC Med Educ |
Healthcare Response | Réponse des soins de santé |
Survey assessed COVID-19 knowledge and associated factors among dental academics in 26 countries. Dental academics
had poorer knowledge of COVID-19 symptoms than of COVID-19 diagnostic methods. Living arrangements, academic degrees, patient load, and magnitude of the epidemic in the country were associated with COVD-19 knowledge among dental academics. |
|
Anschuetz, L, Yacoub, et al |
Otolaryngol Head Neck Surg |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
Quantitatively compare the risk of perioperative droplet formation between microscopic and endoscopic approaches. The
endoscopic technique offers the lowest risk of droplet formation as compared with microscopic approaches, with a significant 4.5-fold reduction of droplets between endoscopic and microscopic epitympanectomy and a 62-fold reduction between endoscopic epitympanectomy
and cortical mastoidectomy. |
|
|
Anushiravani, A, Vahedi, et al |
Middle East Journal of Digestive Diseases |
Healthcare Response | Réponse des soins de santé |
Patients with chronic diseases like inflammatory bowel disease (IBD) may be affected in several ways during this pandemic.
Of 13165 Iranian patients with IBD, 51 have been diagnosed as having COVID-19. IBD patients made 1920 hotline calls. Among the patients with suspicious presentations, 14 COVID-19 infections were diagnosed. Additionally, 1782 patients with IBD from five provinces
actively phone-called among whom 28 definite cases were diagnosed. IBD patients’ follow-up could help in diagnosing the affected IBD patients with COVID-19. Additionally, the performance of protective actions and preparing the patients and physicians for
decisive proceedings are the principles of protection of IBD patients. |
|
|
Apuke, OD, Omar, et al |
Health education research |
Public Health response| Interventions de santé publique |
We proposed a conceptual model combining three theories: uses and gratification theory, social networking sites (SNS)
dependency theory and social impact theory to understand the factors that predict fake news sharing related to COVID-19. We also tested the moderating role of fake news knowledge in reducing the tendency to share fake news. Data were drawn from social media
users (n = 650) in Nigeria, and partial least squares was used to analyse the data. Our results suggest that tie strength was the strongest predictor of fake news sharing related to COVID-19 pandemic. W |
|
|
Ivermectin reduces coronavirus infection in vivo: a
mouse experimental model |
Arevalo, Ana Paula, Pagotto, et al |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
The objective of this study was to test the ivermectin drug in a murine model of coronavirus infection using a type
2 family RNA coronavirus similar to SARS-CoV2, the mouse hepatitis virus (MHV). Overall results demonstrated that viral infection induces the typical MHV disease in infected animals, with livers showing severe hepatocellular necrosis surrounded by a severe
lymphoplasmacytic inflammatory infiltration associated with a high hepatic viral load (52,158 AU), while ivermectin administration showed a better health status with lower viral load (23,192 AU; p<0.05) and few livers with histopathological damage (p<0.05),
not showing statistical differences with control mice (P=NS). Furthermore, serum transaminase levels (aspartate aminotransferase and alanine aminotransferase) were significantly lower in treated mice compared to infected animals. |
|
PMC7228729; Right Ventricular Dilation in Hospitalized Patients With COVID-19 Infection |
Argulian, E, Sud, et al |
JACC Cardiovasc Imaging |
Clinical data| Données cliniques |
Retrospective analysis of COVID-19 patients who underwent clinically indicated echocardiograms, in New York US (n=110).
Right Ventricular (RV) dilation was prevalent in the patient sample using a focused, time-efficient echocardiography protocol. The mechanism of RV dilation is likely multifactorial and includes thrombotic events, hypoxemic vasoconstriction, cytokine milieu,
and direct viral damage. RV dilation was strongly associated with in-hospital mortality in these patients. |
|
Personal Protective Equipment and Mental Health Symptoms Among Nurses During
the COVID-19 Pandemic |
Arnetz, JE, Goetz, et al |
J Occup Environ Med |
Mental Health |
|
Online survey of Michigan, US nurses (n=163) find responders lacking access to adequate PPE (24.9%, n = 163) were more
likely to report symptoms of depression (OR 1.96, 95% CI 1.31, 2.94; P = 0.001), anxiety (OR 1.64, 95% CI 1.12, 2.40; P = 0.01) and post-traumatic stress disorder (OR 1.83, 95% CI 1.22, 2.74; P = 0.003). |
|
A rapid assessment of migrant careworkers' psychosocial
status during Israel's COVID-19 lockdown |
Attal, JH, Lurie, et al |
Isr J Health Policy Res |
Mental Health |
|
This rapid assessment aimed to explore psychosocial status and mental wellbeing of migrant careworkers in Israel during
the ongoing Covid-19 pandemic and determine risk and protective factors associated with mental distress, anxiety, and depression. An online survey collected social and demographic data, including country of origin, residence, age, sex, and time in Israel.
In addition, questions were asked about knowledge of COVID-19 guidelines, access to supplies, and COVID-related racism. Respondents also completed a psychosocial screening tools, the Hopkins Symptom Checklist-10 (HSCL-10), which was used to screen for depression
and anxiety. As of May 3rd, 2020, 307 careworkers responded to the online survey, of whom 120 (39.1%) were found symptomatic using the HSCL-10. Separating the HSCL-10 into subscales, 28.0% were symptomatically anxious, and 38.1% were symptomatic for depression.
Migrant careworkers exhibited high levels of mental distress during the COVID-19 lockdown, associated with lack of confidence or resources to properly care for themselves and their employer. |
|
Baba, IA, Baba, et al |
Computational and mathematical methods in medicine |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
In this paper, we developed a model that suggests the use of robots in identifying COVID-19-positive patients and which
studied the effectiveness of the government policy of prohibiting migration of individuals into their countries especially from those countries that were known to have COVID-19 epidemic. Two compartmental models consisting of two equations each were constructed.
The models studied the use of robots for the identification of COVID-19-positive patients. The effect of migration ban strategy was also studied. Four biologically meaningful equilibrium points were found. Their local stability analysis was also carried out.
Numerical simulations were carried out, and the most effective strategy to curtail the spread of the disease was shown. |
|
|
Fractional Order Model for the Role of Mild Cases in the Transmission of COVID-19 |
Baba, IA, Nasidi, et al |
Chaos, Solitons and Fractals |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, we present a fractional order SIR model incorporating individual with mild cases as a compartment to
become SMIR model. The existence of the solutions of the model is investigated by solving the fractional Gronwall's inequality using the Laplace transform approach. It was shown that when the rate of infection of the mild cases increases, there is equivalent
increase in the overall population of infected individuals. Hence to curtail the spread of the disease there is need to take care of the Mild cases as well. |
|
Babatunde, Olaniyan Akintunde, Olatunji, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
This was an online cross-sectional survey conducted among primary health care workers in Oyo State between March and
April 2020. Using a two-stage sampling technique, we recruited 284 respondents. A semi-structured questionnaire linked to the Google form was used to collect data. In the domains of concern, 66.9%, 53.2%, 51.4%, and 46.5% of the respondents expressed government-related
concern, self-satisfaction related concern, work-related concern and social status related concern respectively. Nurses/midwives (aOR= 0.21, 95% CI = 0.05 – 0.85) had lesser likelihood of expressing concern about COVID-19 while middle staff (aOR= 2.5, 95%
CI = 1.18 – 5.39) and income earner of ≥ N200, 000 (aOR= 2.3, 95% CI = 1.34 – 3.92) had higher likelihood of expressing concern about COVID-19. |
|
|
Badiee, RK, Willsher, et al |
Plastic and Reconstructive Surgery - Global Open |
Healthcare Response | Réponse des soins de santé |
The University of California, San Francisco, Craniofacial Center has continued to serve patients during this acute
period, adopting a hybrid model in which the vast majority of patients are seen through telehealth and a limited number of patients are evaluated in-person. Surveyed patients and families reported high rates of satisfaction, with time savings cited as a particular
benefit. Furthermore, most felt comfortable using the video technology required for their appointment. This experience has demonstrated to us that multidisciplinary craniofacial evaluations can be effectively delivered in a telehealth format and has informed
our conception of idealized clinic structure |
|
|
Limitations of using mobile phone data to model COVID-19 transmission in the
USA |
Badr, HamadaS, Gardner, et al |
The Lancet Infectious Diseases |
Transmission Public health interventions*| Interventions de sant&eacute; publique |
Used county-level epidemiological data from the Johns Hopkins University Center for Systems Science and Engineering2
to compute the COVID-19 growth rate ratio and aggregated anonymised location data from SafeGraph to estimate the time-varying mobility ratio. Findings suggest that mobility has a less significant role in the transmission of SARS-CoV-2 than do other adopted
behavioural changes and NPIs, such as wearing face masks, handwashing, maintaining physical distance, avoiding large gatherings, and closing schools. |
|
Causal Impacts of Teaching Modality on U.S.
COVID-19 Spread in Fall 2020 Semester |
Badruddoza, Syed, Amin, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie |
We study the impact of college openings and teaching modality on county-level COVID-19 cases and deaths using information
of 745 U.S. colleges. We group the colleges by their teaching modes in fall 2020 semester: in-person, online, and hybrid; and employ a logistic model and a gradient boosting algorithm to estimate the propensity scores for the three groups to adjust the pre-treatment
imbalances of college and county level covariates. We find that greater enrollments, individual mask policies, and fewer republican votes in the county are major predictors of adopting online or hybrid modes. Treatment effects provide evidence that college
reopenings, especially with in-person teaching elements, increase daily new cases and deaths. |
|
Bagula, A, Maluleke, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
This paper proposes two models that i) validate the proposed protective measures using epidemic modelling; ii) pre-empt
the evolution of the pandemic through data analytics. The first model builds around the classic SIR model to simulate the main protective measures suggested by the World Health Organisation; while the second built on regression models to predict future confirmed
cases. Real Covid-19 data of the city of Cape Town were used for the simulations and results reveal the accuracy of the models and the relevance of combining simulation modelling and data analytics as relevant tools in the fight against the pandemic. |
|
|
Baillargeon, J, Polychronopoulou, et al |
Psychiatr Serv |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
Study findings suggest COVID-19 patients with substance use disorders are at increased risk for adverse outcomes. The
attenuation of ORs matched for chronic respiratory and cardiovascular diseases associated with substance abuse suggests the observed risks may be partially mediated by these conditions. |
|
|
Bâldea, I |
Advanced Theory and Simulations |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
The COVID‐19 pandemic in a population modelled as a network wherein infection can propagate both via intra‐ and inter‐group
interactions is simulated. The results emphasize the importance of diminishing the inter‐group infections in the effort of substantial flattening/delaying of the epi(demiologic) curve with concomitant mitigation of disastrous economy and social consequences. |
|
|
Ballivian, J, Alcaide, et al |
J Acquir Immune Defic Syndr |
Mental Health |
|
This study examines the influence of resilience on the impact of COVID-related stress and enforced lockdown on mental
health, drug use, and treatment adherence among people living with HIV (PLWH) in Argentina. Participants completed an anonymous online survey to evaluate the impact of COVID-19 on economic disruption, resilience, mental health outcomes (depression, anxiety,
stress, and loneliness), adherence to HIV treatment, and substance use. A total of 1336 PLWH aged 18-82 were enrolled. The impact of economic disruption on mental health ΔF(1,1321) = 8.86, P = 0.003 and loneliness ΔF(1,1326) = 5.77, P = 0.016 was buffered
by resilience. A 3-way interaction between resilient buffering, stress, and sex was significant ΔF(1,1325) = 4.76, P = 0.029. Participants reported less than excellent adherence to medication (33%), disruption to mental health services (11%), and disruption
to substance abuse treatment (1.3%) during lockdown. The impact of COVID-stress and lockdown on emotional distress seemed mitigated by resilience coping strategies, and the buffering impact of resilience on perceived stress was greater among women. |
|
|
Bao, H, Li, et al |
Clinical and Translational Immunology |
Clinical data| Données cliniques |
We aimed to describe and compare changes in the immune and cardiovascular systems of patients with mild versus severe
COVID‐19 at different time points during the course of disease. We identified spleen shrinkage in 27.7% of study patients. Ratios of spleen volume to patient (skin) volume were compared, with evidence that severe patients had more splenic shrinkage than mild
patients. Lymphopenia was observed in 65.3% of patients, and 27.3% of patients had persistently low levels of lymphocytes after discharge. Tachycardia occurred mainly during the first 2 days of hospitalisation, with increases in creatine kinase–myocardial
band levels in 10 (9.9%) patients and arrhythmias in 16 (15.8%) patients. |
|
|
Barello, S, Palamenghi, et al |
Frontiers in Psychology |
Mental Health |
|
A sample of 532 Italian physicians, nurses, and other professionals answered an online survey addressing their levels
of burnout (through the Maslach Burnout Inventory) and frequency of experienced psycho-somatic symptoms, along with some ad hoc items regarding job demands. Results show that levels of burnout and experienced symptoms are correlated with the increased demands
due to the COVID-19 pandemic, while finding a meaning in one’s own work is correlated with personal gratification. |
|
|
Barker, T, Barker, et al |
Surgeon |
Healthcare Response | Réponse des soins de santé |
This paper reviews the activity undertaken between a teaching hospital and its adjacent Independent Hospital and its
implementation under the Independent Sector Provider Contract between NHSE and the Independent Sector. Results: From the instigation of the NHSE contract with the Independent Sector up until 28th June 2020 The Norfolk and Norwich University NHS Trust (NNUH)
delivered 9016 episodes of care including 576 surgical episodes at its nearby Independent Hospital. During the time that a seven day household isolation period was required, no patients from the 31 tested postoperatively were recorded as testing positive for
Covid-19. In the month after moving to a mandatory 14 day period of household isolation, 29 patients had their surgery postponed as they were unable to comply with the required period of isolation. |
|
|
Batista, DV, Vieira, et al |
Diabetology International |
Clinical data| Données cliniques |
In this report, we describe a case of a 56-year-old patient who presented an elevated anion gap metabolic acidosis
during a SARS-CoV-2 infection and was diagnosed with SGLT2-associated euglycemic diabetic ketoacidosis. |
|
|
The Effect of Policy Responses to Infectious Disease on Feelings
of Fear and Anxiety |
Bechtel, MichaelM, O'Brochta, et al |
SSRN- Lancet prepublication |
Mental Health |
|
To successfully address large-scale public health threats such as the novel coronavirus outbreak, policymakers need
to limit feelings of fear and anxiety that threaten social order and political stability. We study how policy response to an infectious disease affects mass fear using data from a survey experiment conducted on a representative sample of the adult population
in the United States (N=5,461). We find that fear and anxiety are strongly affected by the final policy outcome, relatively mildly by the severity of the initial outbreak, and minimally by policy response type and rapidity. This result holds across various
subgroups of individuals regardless of their partisan identification, level of exposure to coronavirus, knowledge of the virus, and several other theoretically relevant characteristics. |
|
Graph based Clustering Algorithm for Social Community Transmission Prediction of COVID-19 |
Behera, Varun Nagesh Jolly, Ranjan, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Transmission |
A system to model the spread of COVID-19 cases after lockdown has been proposed, to define new preventive measures
based on hotspots, using the graph clustering algorithm. a weighted graph of regions with the regions themselves as weighted nodes with weight of the nodes as the number of active cases and the distance as edge weights. The graph can be completely connected
or connected based on a distance threshold. The nodes are the administrative, and the distance measure tells the possible transmission between separate communities. Using this data, the potential regions that can become hotspots can be predicted, and preventive
measures can be devised. |
|
Bell, S, Clarke, et al |
Vaccine |
Public Health response| Interventions de santé publique |
We used a multi-methods approach - involving an online cross-sectional survey and semi-structured interviews - to investigate
parents’ and guardians’ views on the acceptability of a future COVID-19 vaccine. Most survey participants reported they would likely accept a COVID-19 vaccine for themselves (Definitely 55.8%; Unsure but leaning towards yes 34.3%) and their child/children
(Definitely 48.2%; Unsure but leaning towards yes 40.9%). Less than 4% of survey participants reported that they would definitely not accept a COVID-19 vaccine. Survey participants were more likely to accept a COVID-19 vaccine for themselves than their child/children.
Participants that self-reported as Black, Asian, Chinese, Mixed or Other ethnicity were almost 3 times more likely to reject a COVID-19 vaccine for themselves and their children than White British, White Irish and White Other participants. Survey participants
from lower-income households were also more likely to reject a COVID-19 vaccine. In open-text survey responses and interviews, self-protection from COVID-19 was reported as the main reason for vaccine acceptance. Common concerns identified in open-text responses
and interviews were around COVID-19 vaccine safety and effectiveness, mostly prompted by the newness and rapid development of the vaccine. |
|
|
Bender, WR, Hirshberg, et al |
Am J Obstet Gynecol MFM |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Describe the prevalence of positive severe acute respiratory syndrome coronavirus 2 test results among asymptomatic
pregnant women at 2 Philadelphia obstetrical hospitals, characterize the clinical course of those who had a positive result, and report symptom development among all women tested in the 2 weeks after hospitalization. A total of 318 asymptomatic women underwent
severe acute respiratory syndrome coronavirus 2 testing during this 2-week period; 8 women had a positive result. The overall asymptomatic test positive rate was 2.5%. The rate at Hospital of the University of Pennsylvania was 3.8% compared with 1.3% at Pennsylvania
Hospital. Of note, 3 women who were initially asymptomatic developed mild symptoms in the 2 weeks after a positive test result. Repeat severe acute respiratory syndrome coronavirus 2 testing was performed in 14 of the 310 women who initially had a negative
result; 2 women had a positive result on repeat testing. Moreover, 242 and 213 of the 310 women who had a negative result for severe acute respiratory syndrome coronavirus 2 at the time of the initial hospitalization were followed up via telephone at 1 and
2 weeks after admission, respectively. Viral symptoms, including fevers, chills, shortness of breath, or cough, were self-reported in 4.5% and 4.2% of these women at 1 and 2 weeks after discharge, respectively. |
|
|
Binkley, J, Mark, et al |
Rehabilitation Oncology |
Healthcare Response | Réponse des soins de santé |
Objective: The purpose of this report is to describe the implementation of telerehabilitation for one-on-one patient
care and interactive, live, Web-based formats for group patient education, exercise, and support programs during the COVID-19 pandemic. Design: This report describes the concept, materials, and methods used in a community-based clinical setting to serve patients'
needs during COVID-19. Results: Telerehabilitation and interactive Web-based strategies may be useful in meeting the physical and emotional needs of patients with breast cancer. InteractiveWeb-based strategies substantially increased the numbers of patients
reached with survivorship education and support groups during the first 2 months of COVID-19. |
|
|
Bischetti, L, Canal, et al |
Lingua |
Mental Health |
|
We studied the Covid-19 humor appreciation during Italy's lockdown in March 2020. Humor inspired by Covid-19 showed
a mark of aversiveness, but not of funniness. |
|
|
Bistoquet, M, Galtier, et al |
J Hosp Infect |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé Immunology
| Immunologie |
This letter to the editor describes a seroprevalence study of differentially exposed healthcare workers and hospital
personnel to COVID-19 patients. 647 healthcare and hospital personnel volunteers from highly, mildly and unexposed COVID-19 units were included in the analysis. The study included 261 highly and 227 mildly exposed (representing 70% and 93% of the corresponding
eligible workforce respectively), and 159 unexposed volunteers. Despite an increased risk of acquiring COVID-19 in highly exposed personnal, seroprevalence was low, reflecting efficacy of PPE and barrier procedures. Many cases were likely due to extraprofessional
exposures and incomplete compliance to procedures. |
|
|
CXCL10 could drive longer duration of mechanical ventilation
during COVID-19 ARDS |
Blot, M, Jacquier, et al |
Crit Care |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective is to compare alveolar and systemic inflammation response patterns, mitochondrial alarmin release, and
outcomes according to ARDS etiology (i.e., COVID-19 vs. non-COVID-19). There was a trend toward higher concentrations of plasma CCL5, CXCL2, CXCL10, CD40 ligand, IL-10, and GM-CSF, and ELF concentrations of CXCL1, CXCL10, granzyme B, TRAIL, and EGF in the
COVID-19 ARDS group compared with the non-COVID-19 ARDS group. Plasma and ELF CXCL10 concentrations were independently associated with the number of ventilator-free days, without correlation between ELF CXCL-10 and viral load. Mitochondrial DNA plasma and
ELF concentrations were elevated in all ARDS patients, with no differences between the two groups. ELF concentrations of mitochondrial DNA were correlated with alveolar cell counts, as well as IL-8 and IL-1β concentrations. CXCL10 could be one key mediator
involved in the dysregulated immune response. It should be evaluated as a candidate biomarker that may predict the duration of MV in COVID-19 ARDS patients. |
|
Pig Sera-derived Anti-SARS-CoV-2 Antibodies in Surface Plasmon Resonance Biosensors |
Bong, JH, Kim, et al |
Biochip Journal |
Immunology | Immunologie Animal model | Modèle animal |
Anti-coronavirus disease-2019 antibodies against nucleoprotein (NP) were purified from pig sera. Following the separation
of the antibody fraction using a protein-A column, the final yield of the purified antibodies against SARS-CoV-2 NPs was estimated to be 0.26 ± 0.05 % (absolute amount of 143.4 ± 25.2 ng, n=5) from 1 mL of pig sera. The binding activities of the isolated antibodies
were confirmed using immunoassay and immunostaining. Based on the specific binding activity to NPs, a quantitative assay was performed using a surface plasmon resonance (SPR) biosensor. From the dose response curve, the binding constant (Kd) was calculated
to be 185 pM and thelimit o f detection was estimated to be 1.02 pM. The SPR biosensor with the isolated antibodies against SARS-CoV-2 NPs was applied for the detection of SARS-CoV-2, MERS-CoV, and CoV strain 229E in culture fluid. |
|
Borkowska, MJ, Smereka, et al |
Cardiol J |
Healthcare Response | Réponse des soins de santé |
The present study found that out-of-hospital cardiac arrest incidence rate in the Masovian population (central region
of Poland) in March–April 2020 period was 12.2/100,000 adult inhabitants. Return of spontaneous circulation in EMS was observed only in 9.4% of resuscitated patients. The presence of shockable rhythms was associated with better prognosis. The prehospital mortality
did not differ from those reported in the literature. |
|
|
33091284; Changes in Alcohol Use Patterns in the United States During COVID-19
Pandemic |
Boschuetz, N, Cheng, et al |
WMJ : official publication of the State Medical Society of Wisconsin |
Public Health response| Interventions de santé publique |
The aim of this study was to assess changes in alcohol use patterns as a result of social distancing measures. METHODS:
A single online survey was sent to a convenience sample of adults through social media. Self-reported demographics and alcohol use patterns before and during social distancing were obtained. RESULTS: Alcohol Use Disorders Identification Test (AUDIT-C) scores
increased from median value of 3 to 4 (P < 0.0001); the increase was statistically significant only in women (P < 0.0001). Fewer people use alcohol during social distancing; however, in those who use alcohol, the frequency and quantity ingested increased,
as well as the frequency of alcohol use prior to 5 pm. |
|
Bourguiba, R, Delplanque, et al |
Ann Rheum Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
we conducted a survey on SARS-CoV-2 infection in FMF patients followed in Paris area. FMF patients were identified
from the juvenile inflammatory rheumatism (JIR) cohort, an international multicenter data repository and consented to the study. For the purpose of the study, we included only patients fulfilling the international FMF criteria, with a genetic confirmed FMF
diagnosis. 342 patients answered the survey SARS-CoV-2 infection, diagnosis had been retained if the patient displayed clinical symptoms with a positive SARS-CoV-2 reverse transcriptase (RT)-PCR or serology or a typical chest CT scan. All but one of the FMF-COVID+
patients were taking daily colchicine since a median time of 23 years, mostly 1 mg/day |
|
|
Braude, P, Carter, et al |
Int J Cardiol Heart Vasc |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to determine the influence of ACEi and ARBs on COVID-19 mortality and length of hospital
stay. COPE (COVID-19 in Older People) is a multicenter observational study including adults of all ages admitted with either laboratory or clinically confirmed COVID-19. 1371 patients were included from eleven centres between 27th February to 25th April 2020.
Median age was 74 years IQR 61-83]. 28.6% of patients were taking an ACEi or ARB. There was no effect of ACEi or ARB on inpatient mortality (aHR = 0.85, 95%CI 0.65-1.11). For those prescribed an ACEi or ARB, hospital stay was significantly reduced (aHR = 1.25,
95%CI 1.02-1.54, p = 0.03) and in those with hypertension the effect was stronger (aHR = 1.39, 95%CI 1.09-1.77, p = 0.007). Patients and clinicians can be reassured that prescription of an ACEi or ARB at the time of COVID-19 diagnosis is not harmful. The benefit
of prescription of an ACEi or ARB in reducing hospital stay is a new finding. |
|
|
Brierley, Liam, Fowler, et al |
bioRxiv |
Coronavirology| Coronavirologie zoonoses |
We obtained a set of 650 spike protein and 511 whole genome nucleotide sequences from 225 and 187 viruses belonging
to the family Coronaviridae, respectively. We then trained random forest models independently on genome composition biases of spike protein and whole genome sequences, including dinucleotide and codon usage biases in order to predict animal host (of nine possible
categories, including human). In hold-one-out cross-validation, predictive accuracy on unseen coronaviruses consistently reached
∼73%, indicating evolutionary signal in spike proteins to
be just as informative as whole genome sequences. However, different composition biases were informative in each case. Applying optimised random forest models to classify human sequences of MERS-CoV and SARS-CoV revealed evolutionary signatures consistent
with their recognised intermediate hosts (camelids, carnivores), while human sequences of SARS-CoV-2 were predicted as having bat hosts (suborder Yinpterochiroptera), supporting bats as the suspected origins of the current pandemic. |
|
|
Burton, JaneE, Love, et al |
bioRxiv |
Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
The effect of heat on SARS-CoV-2/England/2/2020 viability was assessed by plaque assay and virus culture. Heating to
56°C and 60°C for 15, 30 and 60 minutes led to a reduction in titre of between 2.1 and 4.9 log 10 pfu/ml but complete inactivation was not observed. At 80°C plaques were observed after 15 and 30 minutes of heating, however after 60 minutes viable virus was
only detected following virus culture. Heating to 80°C for 90 minutes and 95°C for 1 and 5 minutes resulted in no viable virus being detected. At 56°C and 60°C significant variability between replicates was observed and the titre often increased with heat-treatment
time. Nucleic acids were extracted and tested by RT-PCR. Sensitivity of the RT-PCR was not compromised by heating to 56°C and 60°C. Heating to 80°C for 30 minutes or more and 95°C for 1 or 5 minutes however, resulted in an increase of at least three Ct values.
This increase remained constant when different dilutions of virus underwent heat treatment. This indicates that high temperature heat inactivation of clinical samples prior to nucleic acid extraction could significantly affect the ability to detect virus in
clinical samples from patients with lower viral loads by RT-PCR. |
|
|
Non-invasive hemodynamic profile of early COVID-19 infection |
Busana, M, Schiavone, et al |
Physiological Reports |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Methods: Twenty-three COVID-19 patients were enrolled in a medical ward. Gas exchange, transthoracic echocardiographic,
and hemodynamic variables were collected. Results: : In the early stages of COVID-19 infection the hemodynamic profile is characterized by a hyperdynamic circulatory state with high CI and low SVRI, while the right heart is functionally unaffected. Our findings
suggest that hypoxemia, viral sepsis or peripheral shunting are possible mechanisms for the vasodilation that dominates at this stage of the disease and may itself worsen the gas exchange. |
|
Buselli, R, Corsi, et al |
Brain Behav Immun Health |
Clinical data| Données cliniques |
Case study of a 50-year-old female nurse who presented with a history of fatigue resulting from minor exertion and
persistent dysphonia. The patient had a history of COVID-19 infection, which lasted about two months with pulmonary and extrapulmonary symptoms. After two RT-PCR negativities for SARS-CoV-2, dysphonia and fatigue due to minor exertionpersisted. The patient,
following the persistence of the symptomatology, was subject to numerous specialist examinations, which showed no organic alterations. Based on her clinical and instrumental history, we hypothesized a psychogenetic dysphonia related to COVID-19. |
|
|
Büssing, A, Hübner, et al |
Frontiers in Psychiatry |
Mental Health |
|
Materials and Methods: Online survey with standardized questionnaires, Meaning in Life Questionnaire, Spiritual and
Religious Attitudes to cope with illness, Gratitude/Awe scale among 292 tumor patientsfrom Germany between May 6 to June 10, 2020. Results: Patients´ wellbeing (WHO5) scores were in the lower range (14.7 ± 6.0); 35% scored < 13, indicating depressive states.
Wellbeing was significantly higher in older persons and lower in younger ones (F=11.1, p<.0001). Most were irritated by different statements about the danger and the course of the corona infection in the public media (60%), and 57% were worrying to be infected
and to have a complicated course of disease. Because of the restrictions, patients noticed changes in their attitudes and behaviors: 1) Perception of nature and silence, 2) Worrying reflections and loneliness Interest in spirituality, 4) Intense relationships |
|
|
Caci, B, Miceli, et al |
Frontiers in Psychology |
Mental Health |
|
We performed a cross-sectional study aimed at testing an integrative moderated mediation model. Our model assigned
the boredom to the mediation role and both the fantasy engagement and perceived control of time to the role of moderators in the relationship between neuroticism and the fear of COVID-19. A sample of 301 subjects, mainly women (68.8%), aged between 18 and
57 years (Mage = 22.12 years; SD = 6.29), participated in a survey conducted in the 1st-week lockdown phase 2 in Italy from May 7 to 18, 2020. Results suggested that neuroticism is crucial in coping with the COVID-19 pandemic. We also found that people with
high neuroticism tend to feel bored, and the relationship between neuroticism and boredom seems enhanced if one is involved in negative fantasies. Therefore, this result could also explain the positive effect between boredom and fear of COVID-19 we found in
the current study. |
|
|
Calvo, E, Corbacho-Alonso, et al |
Journal of Personalized Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Authors employed an -omics strategy in order to identify variations in protein abundance in spinal cord injury patients
with and without COVID-19. Results suggest a key role of heparin in the response of spinal cord injury patients to COVID-19 infection, showing a significant correlation between these proteins and heparin dose. |
|
|
Canetti, D, Dell'Acqua, et al |
New Microbiol |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes Immunology | Immunologie |
Describe the outcome of a SARSCoV-2 IgG/IgM rapid test, and discuss the potential suitability of antibody testing.
Analysed the proportion of those who developed a positive IgM/IgG response for SARS-CoV-2. 97 subjects underwent qPCR for SARS-CoV-2 through nasal swab, which resulted positive in 40/43 of symptomatic patients, 2/40 of asymptomatic HCW, in no subjects with
suspected COVID-19 (clinical and radiological findings) then excluded by repeated nasal swabs and alternative diagnosis (COVID-19-negative patients, CNPs), and in 6/6 of patients with confirmed diagnosis and negative follow-up nasal swabs (COVID-19-recovered
patients, CRPs). IgM resulted positive in 8/43 of symptomatic patients and in 1/6 of CRPs. IgG resulted positive in 36/43 of symptomatic patients, 2/40 of HCW, and in 1/8 and 6/6 of CNPs and CRPs, respectively. A comparison between an IgG/IgM Rapid Test and
a following CLIA test showed consistency in negative results in 25/28 of HCW and 8/8 of CNPs tested. |
|
|
Pulmonary Embolism Rate in Patients Infected with Severe Acute Respiratory Syndrome
Coronavirus 2 |
Capaccione, KM, Li, et al |
Blood Res |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To better understand the incidence of PE in a more general population of patients with upper respiratory symptoms suspicious
of COVID19 infection or PE, we studied the incidence of pulmonary embolism in patients presenting to our institution with upper respiratory symptoms during the height of the pandemic. We correlated this with COVID-19 infection status and other clinical characteristics
to better understand the association with pulmonary embolism. Our study demonstrated no difference in the rate of pulmonary embolism in patients with COVID-19 compared to patients presenting with similar symptoms without COVID-negative. |
|
Carrouel, F, Viennot, et al |
Trials |
RCT |
This paper outline the protocal for a multi-center, randomised controlled trial (RCT) with two parallel arms (1:1 ratio)
aims to describe the evolution of the SARS-CoV-2 salivary viral load of patients infected with Covid-19, performing 7 days of tri-daily mouthwashes with and without antivirals and to compare the evolution of the SARS-CoV-2 nasal and salivary viral load according
to the presence or absence of antivirals in the mouthwash. |
|
|
Caruso, F, Rossi, et al |
Journal of Infection and Public Health |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
A mechanism for this inhibition of the SARS-CoV-2 Mpro protease is described, specifically due to formation of a covalent
bond between S(Cys145) and an embelin C(carbonyl). Additional consideration was given to another natural product, emodin, recently patented against Covid-19, as well as some therapeutic quinones, vitamin K, suspected to be involved in Covid-19 action, and
coenzyme Q10. All show structural similarities with embelin, dexamethasone and methyl prednisolone results. Our data on embelin and related quinones indicate that these natural compounds may represent a feasible, strategic tool against Covid-19. |
|
|
Carvalho, ED, Carvalho, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This paper presents a methodology for diagnosing COVID-19 using convolutional neural network (CNN) for feature extraction
in CT exams and its classification using XGBoost. The methodology consists of using a CNN to extract features from 708 CTs, 312 with COVID-19, and 396 Non-COVID-19. After the extracted data, we used XGBoost for classification. The results show an accuracy
of 95.07, recall of 95.09, precision of 94.99, F-score of 95, AUC of 95, and a kappa index of 90. The results obtained show that the proposed methodology can be used as a diagnostic aid system by specialists. |
|
|
Castillo-Laborde, Carla |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
Our methodology consists of considering some outcomes that are consequences of the nonpharmaceutical interventions
that a decision maker aims to make as low as possible. The peak demand for intensive care units (ICU) and the total number of days in lockdown are examples of such outcomes. If an epidemiological indicator is used to trigger the interventions, there is naturally
a trade-off between the outcomes that can be seen as a curve parameterized by the trigger threshold to be used. The computation of these curves for a group of indicators then allows the selection of the best indicator the curve of which dominates the curves
of the other indicators. This methodology is illustrated using indicators in the context of COVID-19 using deterministic compartmental models in discrete-time, although the framework can be adapted for a larger class of models. |
|
|
Cereser, L, Da Re, et al |
Clinical imaging |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to assess whether high-resolution computed tomography (HRCT) is associated to short-time
development of severe disease in patients with COVID-19 pneumonia. Short-time onset of severe COVID-19 was associated to TLI >15 and OP pattern score > 5. Severe disease was not associated to comorbidities. |
|
|
Chalela, R, Gracia-Arnillas, et al |
Med Intensiva |
Clinical data| Données cliniques |
Clinical report of a 62-year-old man admitted with a diagnosis of SARS-CoV-2 pneumonia in a hospital ward (Article
in Spanish). |
|
|
Chan, CW, Shahul, et al |
Am J Clin Pathol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
Evaluated the analytical and clinical performance of the Truvian Easy Check coronavirus disease 2019 (COVID-19) IgM/IgG
anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody test. The Easy Check device showed excellent analytical performance and compares well with the Roche Elecsys antibody assay, with an overall concordance of 98.6%. Clinical performance
showed a sensitivity of 96.6%, a specificity of 98.2%, and an overall accuracy of 98.1%. |
|
|
Chen, H, Wang, et al |
Neurobiology of Stress |
Mental Health |
|
Psychological conditions were evaluated by the multiple psychological evaluation scales in HCWs at the Affiliated Hospital
of Xuzhou Medical University in Xuzhou City (a non-core epidemic area in China) during COVID-19 epidemic. HCWs were divided into two groups: HCWs with high-risk (HHCW) group (who worked in wards for COVID-19 patients) and HCWs with low-risk (LHCW) group (who
worked in wards for non-COVID-19 patients in the same hospital). This study demonstrated that HCWs in HHCW group had a higher chance of developing PTSS when compared with those in LHCW group. T |
|
|
Chen, J, Han, et al |
Virulence |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Retrospectively investigated the clinical characteristics of 648 consecutive subjects who were enrolled in the study
and were divided into asymptomatic carriers, mild cases, ordinary cases, severe or critical cases, and evaluated their impact on disease severity by means of Spearman correlation and multiple regression analyses. a total of 648 subjects on admission with a
mean age of 45.61 y including 345 males and 303 females were enrolled in our study. The leukocyte, lymphocyte, eosinophil, platelet, C-reactive protein, interleukin-6, CD3+, CD4+, and CD8 + T lymphocyte levels, and the erythrocyte sedimentation rate differed
significantly among the groups. Disease severity was negatively associated with the CD3+, CD4+ and CD8+ T lymphocyte levels. The significant diagnostic predictors of asymptomatic carriers of COVID-19 included the blood cell, cytokine, and T lymphocyte subset
levels. |
|
|
Chen, Peng, Wu, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
To address the curse of dimensionality and the ill-posedness of the high-dimensional inference problem, we propose
use of a dimension-independent projected Stein variational gradient descent method, and demonstrate the intrinsic low-dimensionality of the inverse problem. We present inference results with quantified uncertainties for both New Jersey and Texas, which experienced
different epidemic phases and patterns. Moreover, we also present forecasting and validation results based on the empirical posterior samples of our inference for the future trajectory of COVID-19. |
|
|
A psychological health support scheme for medical teams in COVID-19 outbreak and
its effectiveness |
Cheng, W, Zhang, et al |
General Psychiatry |
Mental Health |
|
Aims To design a systematic, full-coverage psychological health support scheme for medical teams serving large-scale
emergent situations, and demonstrate its effectiveness in a real-world study in Leishenshan Hospital during the COVID-19 epidemic in Wuhan, China. Methods The scheme integrates onsite and online mental health resources and features team-based psychosocial
support and evidence-based interventions. Results The scheme economically supported a special medical team of 156 members with only one onsite psychiatrist. Our data reflected that the entire medical team maintained an overall positive outlook (7-9 out of
10 in a Daily Mood Index, DMI) for nearly 6 weeks of continuous working. Since the scheme promoted self-strengths and positive self-affirmation, the number of self-reports of life-related gains were high and played a significant effect on the DMI. Our follow-up
investigations also revealed that multiple modules of the scheme received high attention and evaluation levels. |
|
COVID-19 In Children Across Three Asian Cosmopolitan Regions |
Chua, GT, Xiong, et al |
Emerg Microbes Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Children confirmed with COVID-19 infection from the Republic of Korea, the Hong Kong Special Administrative Region
(HKSAR) and Wuhan, China, during their first waves of local outbreaks were analyzed. In general, adolescents were more likely to be asymptomatic and less likely to develop fever, but required longer hospital stays. The majority patients in this pediatric Asian
cohort had mild disease, and none developed pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2. Clinical characteristics were influenced by travel history and age. |
|
33086857;
Délka vylučování SARS-CoV-2 u pacientů uzdravujících se z COVID-19 |
Cimrman, Š, Macková, et al |
Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti
J.E.Purkyne |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Deep nasopharyngeal swabs repeatedly collected from a cohort of one hundred patients with COVID-19 were tested for
SARS-CoV-2 RNA using RT-PCR (real-time polymerase chain reaction). The median period of viral genome detectability was 15 days. Furthermore, the authors tested the hypothesis on the relationship between the severity of COVID-19 and the period in which the
viral genome is detectable. They did not find any statistically significant difference in the duration of viral clearance between patients with asymptomatic to mild disease or severe disease. |
|
Colaneri, M, Novelli, et al |
J Public Health (Oxf) |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
Share our experience as an early hit hospital where standard infection control practices have been conscientiously
applied and effective. In addition, we want to offer an insight on modifiable risk factors for health care workers (HCWs)-related infection. The cumulative incidence of SARS-CoV-2 infection among the screened HCWs was 11.33%. Working in a COVID-19 ward, being
a former smoker (versus being a person who never smoked) and BMI was positively associated with SARS-CoV-2 infection, whereas being a current smoker was negatively associated with this variable. |
|
|
Predicting the Evolution of COVID-19 Cases and Deaths Through a Correlations-Based
Temporal Network |
Colliri, T, Delbem, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, we introduce a semi-supervised regression model which makes use of a correlations-based temporal network,
by considering the evolution of COVID-19 in different world regions, in order to predict the evolution of new confirmed cases and deaths in 27 federal units of Brazil. In this approach, each node in the network represents the COVID-19 time series in a specific
region, and the edges are created according to the variations similarity between each pair of nodes, at each new time step. The results obtained, by predicting the weekly new confirmed cases and deaths in each region, are promising, with a median and mean
absolute percentage error of 21% and 24%, respectively, when predicting new cases, and a median and mean absolute percentage error of 16% and 23%, respectively, when predicting new deaths, for the considered period. |
|
Cordoba, Juan Carlos, Ripoll, et al |
SSRN- Lancet prepublication |
Surveillance Public Health response| Interventions de santé publique Economics | Économie |
Official recession figures ignore the costs associated with the loss of human life due to COVID-19. Key for the estimates
are the number of dead, the individual's willingness to accept mortality risk, and society's willingness to accept inequality. Our model features tractable heterogeneity, constant relative risk aversion to mortality risk, and age-specific survival rates. Using
an estimated death toll of 400 thousand people for the US during a year, and a baseline 10% recession, we find that the corresponding full recession is 26% on average across individuals, 17% for a median voter, 13% for a planner with mild aversion to inequality,
and 19% for a planner with larger aversion. A median voter would be willing to pay 23%, a social planner with mild aversion to inequality only 11%, while a log-planner would pay 73%. |
|
|
Costa, A, Almeida, et al |
Enfermedades infecciosas y microbiologia clinica |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aims to assess the characteristics of suspected COVID-19 and the rate of confirmed COVID-19 in a pediatric
population at the beginning of the pandemic in Portugal. 94 patients were included and all of them were symptomatic and treated without hospitalization. The most common symptoms were cough (80%; n = n = 68) and fever (60%; n = 56). There was only one positive
for SARS-CoV-2 in a five-year-old child with mild illness without epidemiologic linkage. 75), rhinorrhea (72%;). This study showed a low rate of confirmed COVID-19 in children. The causes for this low rate can be multifactorial and illustrates how differently
this virus spreads in the pediatric population. |
|
|
Courtellemont, Laura, Guinard, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The current prospective study was designed to assess diagnostic performances of an antigen-based rapid detection test
(COVID-VIRO) in a real-life setting. COVID-VIRO test had 100% specificity and above 95% sensitivity. |
|
|
PMC7434413; Coronavirus infection in a high-risk obstetrical population of the
South Bronx, New York |
Curi, B, Sabre, et al |
Am J Obstet Gynecol MFM |
Clinical data| Données cliniques |
Outline the clinical course of 33 pregnant patients from a South Bronx community hospital with symptomatic COVID-19
infection, 81.8% of which have underlying medical conditions. |
|
Dang, Hai-AnhH, Malesky, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
Despite a rich literature studying the impact of inequality on policy outcomes, there has been limited effort to bring
these insights into the debates about comparative support for government responses to the COVID-19 pandemic. We fill in this gap by analyzing rich survey data from six countries spanning different income levels and geographical locations — China, Italy, Japan,
South Korea, the United Kingdom, and the United States. We find that poorer individuals are less supportive of government responses, and that poorest individuals are least supportive. Furthermore, poorer individuals residing in more economically unequal countries
offer even less government support. We also find that both economic and non-economic factors could affect the poor's decisions to support stringent government policies. These findings suggest that greater transfers to the poor may ameliorate their resistance,
increase support for strict policies, and may reduce the potential deepening of social inequalities caused by the pandemic. |
|
|
Second episode of COVID-19 in health professionals: Report of two cases |
de Brito, CAA, Lima, et al |
International Medical Case Reports Journal |
Clinical data| Données cliniques |
We report cases of two doctors who had two episodes of COVID-19 with positive RT-PCR (reverse transcriptase polymerase
chain reaction) test results, raising the probability of reinfection. |
|
De Giorgi, A, Fabbian, et al |
European review for medical and pharmacological sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Our aim was to assess a novel modified Elixhauser index (mEi) and the Charlson Comorbidity Index (CCI) for predicting
in-hospital mortality (IHM) in internal medicine patients with SARS-CoV-2 infection. PATIENTS AND METHODS: This single-center retrospective study enrolled all consecutive patients discharged from internal medicine unit with confirmed SARS-CoV-2 infection.
Both the mEi and CCI were easily calculated from administrative data. RESULTS: The total sample consisted of 151 individuals, and 30 (19.9%) died during their hospital stay. Deceased subjects were older and had a higher burden of comorbidities: the mEi and
CCI were 29.9±11 vs. 8.8±9.2 and 4.6±2.6 vs. 1.2±2, respectively. Only the mEi was independently associated with IHM, and ROC curves analysis showed that the AUCs were 0.863 and 0.918 for the CCI and for mEi, respectively. |
|
|
De Maria, M, Ferro, et al |
International Journal of Environmental Research and Public Health |
Mental Health |
|
To develop the Self-Care in COVID-19 (SCOVID) scale we administered the 20-item SCOVID scale to a sample of 461 Italians
in May/June 2020. Conclude that the SCOVID scale is a new instrument measuring psychometric characteristics of self-care in the COVID-19 pandemic with adequate validity and reliability. |
|
|
Mortality Rates From COVID-19 Are Lower In Unionized Nursing Homes |
Dean, A, Venkataramani, et al |
Health Aff (Millwood) |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
This study used cross-sectional regression analysis to examine the association between the presence of health care
worker unions and COVID-19 mortality rates in 355 nursing homes in New York State. Health care worker unions were associated with a 1.29-percentage-point reduction in mortality, which represents a 30 percent relative decrease in the COVID-19 mortality rate
compared with facilities without these unions. Unions were also associated with greater access to PPE, one mechanism that may link unions to lower COVID-19 mortality rates. |
|
Denes, E |
Brain Behav Immun Health |
Clinical data| Données cliniques |
In this case study we observed a patient who simultaneously presented dysesthesia and a viral exanthema in the same
skin areas. The SARS-Cov-2 infection was documented thanks to RT-PCR. On day 2 after the onset of disease, dysesthesia appeared acutely on his back, the back of both arms and the chest. Symptoms followed metameres (Proximal part of C7–C8 and from T2 to T9),
were symmetrically distributed and had the same intensity in all areas. |
|
|
Dev, Kapal, Khowaja, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The current COVID-19 pandemic has motivated the researchers to use artificial intelligence techniques for potential
alternatives to reverse transcription polymerase chain reaction (RT-PCR) due to the limited scale of testing. The chest X-ray (CXR) is one of the alternatives to achieve fast diagnosis but the unavailability of large scale annotated data makes the clinical
implementation of machine learning-based COVID detection methods difficult. Another important issue is the usage of ImageNet pre-trained networks which does not guarantee to extract reliable feature representations. In this paper, we propose the use of hierarchical
convolutional network (HCN) architecture to naturally augment the data along with diversified features. The HCN uses the first convolution layer from COVIDNet followed by the convolutional layers from well known pre-trained networks to extract the features.
The use of the convolution layer from COVIDNet ensures the extraction of representations relevant to the CXR modality. We also propose the use of ECOC for encoding multiclass problems to binary classification for improving the recognition performance. Experimental
results show that HCN architecture is capable of achieving better results in comparison to the existing studies. The proposed method can accurately triage potential COVID-19 patients through CXR images for sharing the testing load and increasing the testing
capacity. |
|
|
Atrioventricular Block in Children With Multisystem Inflammatory Syndrome |
Dionne, A, Mah, et al |
Pediatrics |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Retrospective cohort study of children and young adults aged ≤21 years admitted with MIS-C. Demographic characteristics,
electrocardiogram (ECG) and echocardiogram findings, and hospital course were described. Among 25 patients admitted with MIS-C (60% male; median age 9.7 interquartile range 2.7-15.0] years), ECG anomalies were found in 14 (56%). First-degree atrioventricular
block (AVB) was seen in 5 (20%) patients a median of 6 (interquartile range 5-8) days after onset of fever and progressed to second- or third-degree AVB in 4 patients. Children with MIS-C are at risk for atrioventricular conduction disease, especially those
who require ICU admission and have ventricular dysfunction. ECGs should be monitored for evidence of PR prolongation. |
|
Dlamini, WM, Dlamini, et al |
Appl Geogr |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We explored the potential to undertake a spatial risk assessment of an emerging pandemic under data scarcity in Eswatini.
We used a set of socio-economic and demographic variables to identify epidemic risk prone areas in the country. Three risk zone levels for COVID-19 were identified in the country. The analysis showed that about 29% (320 818) of the population were located
in the high risk zone and these were people who could potentially be infected with COVID-19 in the absence of mitigation measures. We provided an estimation method that could support the pandemic risk forecasting, preparedness and response measures in the
midst of data scarcity. |
|
|
Doganci, S, Ince, et al |
European review for medical and pharmacological sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this article a new prediction tool is presented in combination of Turkish experience during pandemic. Non-survivor
and survivor patients were compared to find out a prediction scoring model for mortality. There was 34 8.56% (95% CI:0.06-0.11)] mortality during study period. Mean age of patients was 57.1±16.7 years. Older age, comorbid diseases, symptoms, such as fever,
dyspnea, fatigue and gastrointestinal and WBC, neutrophil, lymphocyte count, C-reactive protein, neutrophil-to-lymphocyte ratio of patients in non-survivors were significantly higher. Univariate analysis demonstrated that OR for prognostic nutritional index
(PNI) tertile 1 was 18.57 (95% CI: 4.39-78.65, p<0.05) compared to tertile 2. Performance statistics of prediction scoring method showed 98% positive predictive value for criteria 1. |
|
|
Cycle Threshold to Test Positivity in COVID-19 for Return to Work Clearance in
Health Care Workers |
Domeracki, S, Clapp, et al |
J Occup Environ Med |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Healthcare
Response | Réponse des soins de santé |
Determine whether reverse transcriptase polymerase chain reaction (RT-PCR) cycle amplifications until detection, the
cycle threshold (Ct), could help inform return to work (RTW) strategies for health care workers (HCWs) recovering from COVID-19 infection. Data for 12 healthcare workers showed that time elapsed until RT-PCR test-based RTW clearance ranged from 7 to 57 days
(median, 34.5 days). Lower initial Ct correlated with the total time elapsed until clearance (r = -0.80; P = 0.002). |
|
Duplaga, M |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
This paper is focused on the assessment of the prevalence of beliefs in conspiracy theories related to COVID-19 in
Polish society. The analysis reported here was based on the data from an online survey of a representative sample (n = 1002) of the adult population of Polish Internet users. The percentage of supporters of particular conspiracy theories in the study sample
ranged from 43% to 56%. The CCBS was significantly associated with age, education level, vocational status and both HL and eHL. However, it was lower for persons with higher HL (regression coefficient (B) = −0.04, p < 0.001) but higher for those with higher
eHL (B = 0.04, p = 0.038). The most influential predictors of CCBS were age (standardised regression coefficient (β) = −0.21) and education level (β from 0.08 to 0.16 for respondents with lower education levels and those with master’s degrees). |
|
|
Ebada, SS, Al-Jawabri, et al |
RSC Advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
An edible and folk medicinal Jordanian plant Crepis sancta (Asteraceae) was selected for this study. All isolated compounds
were assessed for their in vitro anti-inflammatory, antiallergic and in silico COVID-19 main protease (Mpro) inhibitory activities. Among the tested compounds, compounds 5-10 revealed potent anti-inflammatory, antiallergic and COVID-19 protease inhibitory
activities. Chrysosplenetin (10) is considered as a promising anti-inflammatory and antiallergic lead structure adding to the phytotherapeutic pipeline. Moreover, its inhibitory activity against SARS-CoV-2 Mpro, supported by docking and molecular dynamic studies,
strengthens its potential as a lead structure paving the way toward finding out a natural remedy to treat and/or to control the current COVID-19 pandemic |
|
|
Egede, LE, Walker, et al |
Health Aff (Millwood) |
Epidemiology| Épidémiologie |
Racial/ethnic differences existed in adults who screened positive for COVID-19 in US (4.5 percent of non-Hispanic Whites,
14.9 percent of non-Hispanic Blacks, and 14.8 percent of Hispanics). After adjustment for demographics and comorbidities, Blacks and Hispanics were more than three times more likely to screen positive and two times more likely to be hospitalized relative to
Whites, and Hispanics were two times more likely to die than Whites. |
|
|
PMC7560268; Retrospective overview of a COVID-19 outbreak in Mauritania |
El Vally, A, Bollahi, et al |
New Microbes New Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Mauritania health authorities reported 41 862 serologic and PCR tests performed, of which 4472 (10.7%) were positive
for SARS-CoV-2. Male subjects were significantly more affected (57.1%) than female subjects (42.9%). Individuals of the age groups 15-34 years (35.8%) and 35-54 years (36.6%) were the most affected. There were 129 deaths (2.9%), 1677 recoveries (37.5%) and
2666 active cases (59.6%) of which 2261 (84.8%) were asymptomatic, 394 (14.7%) had mild symptoms and 11 (0.4%) had severe symptoms. A large proportion of fatalities (72%, 85/118) occurred among adults aged ≥55 years. Of 4472 positive cases, 4241 (94.8%) were
infected through contact with a confirmed COVID-19 case, 133 (3.0%) had no contact with a confirmed COVID-19 case and 98 (2.2%) were imported. |
|
Ezeah, G, Ogechi, et al |
Health education research |
Public Health response| Interventions de santé publique |
In this study, we tested the effectiveness of interpersonal communication in awareness creation and knowledge about
COVID-19 among rural communities in a developing country. The sample size was made up 470 participants. The results demonstrate that interpersonal communication is effective in creating awareness about COVID-19 among rural communities. It was also found that
interpersonal communication was effective in improving knowledge about the pandemic among rural communications. We explored the implications of these findings on healthcare delivery. |
|
|
Falgarone, G, Pamoukdjian, et al |
Aging (Albany NY) |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Lung ultrasonography (LUS) has been proposed as an alternative method to monitor patients with COVID-19 pneumonia.
LUS could help in the orientation of dyspneic patients to intensive care. It could also be proposed when there is limited access to CT scan in the context of a pandemic crisis, or to implement clinical lung examinations for outpatient follow-up. |
|
|
Faye, AS, Lee, et al |
J Rheumatol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Patients with autoimmune disease were more likely to have at least one comorbidity (25.8% vs. 12.9%, p=0.03), take
chronic immunosuppressive medications (66.1% vs. 4.0%, p<0.01), and have had a solid organ transplant (16.1% vs. 1.6%, p<0.01). There were no significant differences in intensive care unit admission (14.2% vs. 19.4%, p=0.44), intubation (14.2% vs. 17.7%, p=0.62)
or death (17.5% vs. 14.5%, p=0.77). Among patients hospitalized with COVID-19, individuals with autoimmune disease did not have an increased risk of a composite outcome of intensive care unit admission, intubation, or death. |
|
|
Fazeli, S, Mohammadi Zeidi, et al |
Addict Behav Rep |
Mental Health |
|
Depression, anxiety, and stress mediates the association between internet gaming disorder and insomnia, during the
COVID-19 pandemic. |
|
|
Genetic diversity analysis of the D614G mutation in
SARS-CoV-2 |
Felix, PierreT, Silva, et al |
bioRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
In this work, we evaluated the levels of genetic diversity in 18 genomes of SARS-CoV-2 carrying the D614G mutation,
coming from Malaysia and Venezuela and publicly available at the National Center of Biotechnology and Information (NCBI). The results revealed the presence of only 57 sites of polymorphic and parsimonium-informative among the 29,827bp analyzed and the analyses
based on FST values confirmed the presence of two distinct genetic entities with fixation index of 22% and with a higher component of population variation (78.14%). |
|
Ferrari, D, Locatelli, et al |
Int J Vitam Nutr Res |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Retrospectively analyzed the vitamin D (VitD) levels (measured as 25-hydroxyvitamin-D) from a cohort of 347 patients
admitted to a northern Italian Hospital as suspected COVID-19s. Of them, 128 were positive (83 males, aged 62.7 ± 14.2 and 45 females, aged 69.3 ± 15.6) and 219 were negative (107 males, aged 62.8 ± 19.5 and 112 females, aged 54.3 ± 20.1). The averaged VitD
levels were similar in the two groups: 21.8 ± 16.1 ng/mL and 22.8 ± 14.0 ng/mL for the COVID-19 positive and negative group respectively, as well as the percentage of individuals having VitD levels below 30 ng/mL: 78.9% and 73.5% for the COVID-19 positive
and negative group respectively. Because a large portion of patients were below the suggested 30 ng/mL threshold, we can't exclude that VitD supplementation, restoring normal levels, might be beneficial in reducing the risk of infection. |
|
|
First, JM, Shin, et al |
Journal of Loss and Trauma |
Mental Health |
|
In the current study, a structural equation model tested the direct and indirect relationships of a variety of proximity
variables including COVID-19 exposure, media use (traditional and social), and interpersonal communication on stress and depression with a U.S. sample of 1,545 adults. Results found that COVID-19 exposure had a direct effect on stress and an indirect effect
on stress and depression through media use (traditional and social) and interpersonal communication. |
|
|
Preliminary Results of Tocilizumab and Interferon a-2b Treatment of SARS-CoV-2 |
Fleming, RichardM, Fleming, et al |
Research Square prepub |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Seven patients receiving Hydroxychloroquine (HCQ) and Zinc (Zn) for CoVid-19 with PCR positive results were admitted
to hospital after failing to improve. Following NCT04349410 protocol and failure to improve with elevated interleukin-6 and ferritin levels, patient’s treatment were changed following measurement of Corona Virus Pneumonia (CVP). Follow up measurements of CVP
confirmed improvement with combined intravenous Tocilizumab, Interferon a-2b nebulizer, Atrovent nebulizer and SQ heparin treatments. |
|
Forbes, Harriet, Morton, et al |
medRxiv |
Epidemiology| Épidémiologie |
We investigated whether risk of infection with SARs-CoV-2 and severe outcomes differed between adults living with and
without children. Among 9,157,814 adults ≤65 years, living with children 0-11 years was not associated with increased risks of recorded SARS-CoV-2 infection, COVID-19 related hospital or ICU admission but was associated with reduced risk of COVID-19 death
(HR 0.75, 95%CI 0.62-0.92). Living with children aged 12-18 years was associated with a small increased risk of recorded SARS-CoV-2 infection (HR 1.08, 95%CI 1.03-1.13), but not associated with other COVID-19 outcomes. Living with children of any age was also
associated with lower risk of dying from non-COVID-19 causes. Among 2,567,671 adults >65 years there was no association between living with children and outcomes related to SARS-CoV-2. We observed no consistent changes in risk following school closure. |
|
|
Lessons in Resilience: Initial Coping among Older Adults during the COVID-19 Pandemic |
Fuller, HR, Huseth-Zosel, et al |
Gerontologist |
Mental Health |
|
This study explores older adults' coping experiences and strategies during the initial weeks of the COVID-19 pandemic.
A Midwestern sample of 76 older adults aged 70-97 completed a phone interview about their experiences with social distancing due to COVID-19. Mean perceived coping level (on a scale from 1-10) was 7.9, with 87% of participants rating their coping positively.
Primary themes that emerged included: 1) staying busy, 2) seeking social support, and 3) having a positive mindset. Contrary to predominant messaging about the vulnerability of older adults, these findings highlight the resilient nature of older adults in
terms of their psychological coping and adaptability during COVID-19. |
|
Galván-Román, JM, Rodríguez-García, et al |
Journal of Allergy and Clinical Immunology |
Therapeutics| Thérapeutique |
We sought to determine whether baseline IL-6 serum levels can predict the need for invasive mechanical ventilation
(IMV) and the response to tocilizumab (TCZ). A retrospective observational study was performed in hospitalized patients diagnosed with COVID-19. One hundred forty-six patients were studied, predominantly males (66%); median age was 63 years. Forty-four patients
(30%) required IMV, and 58 patients (40%) received treatment with TCZ. IL-6 levels greater than 30 pg/mL was the best predictor for IMV (odds ratio, 7.1; P < .001). Early administration of TCZ was associated with improvement in oxygenation (arterial oxygen
tension/fraction of inspired oxygen ratio) in patients with high IL-6 (P = .048). Patients with high IL-6 not treated with TCZ showed high mortality (hazard ratio, 4.6; P = .003), as well as those with low IL-6 treated with TCZ (hazard ratio, 3.6; P = .016).
No relevant serious adverse events were observed in TCZ-treated patients. |
|
|
Regression Analysis of COVID-19 using Machine Learning Algorithms |
Gambhir, E, Jain, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper aims to provide a better understanding of how various Machine Learning models can be implemented in real-world
situations. Apart from the analysis done on the world figures, this paper also analyzes the current trend or pattern of Covid-19 transmission in India. With the help of datasets from the Ministry of Health and Family Welfare of India, this study puts forward
various trends and patterns experienced in different parts of the world. The data to be studied has been obtained for 154 days i.e. from January 22, 2020, till June 24, 2020. For future references, the data can be further analyzed, and more results can be
obtained. |
|
Thyroid hormone concentrations in severely or critically ill patients with COVID-19 |
Gao, W, Guo, et al |
J Endocrinol Invest |
Epidemiology| Épidémiologie Long-Term Sequelae |
|
Study the characteristics of thyroid hormone levels in patients with COVID-19 and to explore whether thyroid hormone
predicts all-cause mortality of severely or critically ill patients.FT3 concentration was significantly lower in patients with severe COVID-19 than in non-severely ill patients. Reduced FT3 independently predicted all-cause mortality of patients with severe
COVID-19. |
|
COVID-19 In-Hospital Mortality and Use of Renin-Angiotensin System Blockers in
Geriatrics Patients |
Genet, B, Vidal, et al |
J Am Med Dir Assoc |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The aim of this study was to assess the relationship between angiotensin receptor blockers (ARBs) and angiotensin-converting
enzyme inhibitor (ACEI) use and in-hospital mortality in geriatric patients hospitalized for COVID-19. This observational retrospective study was conducted in a French geriatric department. Patients were included between March 17 and April 18, 2020. In very
old subjects hospitalized in geriatric settings for COVID-19, mortality was significantly lower in subjects treated with ARB or ACEI before the onset of infection. |
|
PMC7480442; Rapid SARS-CoV-2 inactivation by commonly available chemicals on inanimate
surfaces |
Gerlach, M, Wolff, et al |
J Hosp Infect |
Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
We evaluated single components of disinfectants and household cleaning agents against SARS-CoV-2 on various surfaces.
In this study, surfaces were challenged with SARS-CoV-2, allowed to dry for 1 h and subsequently treated with 70% EtOH, 70% IPA, 0.1% H2O2 or 0.1% SLS for 30 s and 60 s. SARS-CoV-2 remained viable on all surfaces throughout the 1h dehydration period with ≤0.5
log10 TCID50/mL titre reduction. SARS-CoV-2 was highly susceptible to 70% EtOH, 70% IPA, 0.1% H2O2 and 0.1% SLS treatment. For EtOH and IPA, complete viral inactivation to the limit of detection was observed within 30 s of treatment. Although the titre was
greatly reduced, viable SARS-CoV-2 could be detected after 30 s of treatment with H2O2 and SLS. After 60 s, effective SARS-CoV-2 inactivation with logarithmic reduction of viral infectivity by more than 4.0 log10 was documented for all tested chemicals. |
|
Ghosh, R, Chakraborty, et al |
Journal of Molecular Structure |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Among J. adhatoda six alkaloids, anisotine interacts strongly with SARS CoV-2 Mpro. Anisotine interacts with both the
catalytic residues (His41 and Cys145) of Mpro. |
|
|
Giménez-Dasí, M, Quintanilla, et al |
Frontiers in Psychology |
Mental Health |
|
The objective of the present study was to investigate the psychological effects that this confinement has had on the
psychological well-being of a sample of children from Madrid. A total of 167 families with children aged between 3 and 11 years participated in this study. The parents evaluated the children through the System of Evaluation of Children and Adolescents (SENA)
scale in the month of February and refilled part of the same scale after the children had spent between 4 and 6 weeks confined. The comparison between the two measures showed no change among the 3-year-old children. However, change was observed among the 6–10-year-old.
Children in Primary Education obtained lower scores in dimensions related to self-regulation (emotional, attentional, and behavioral) and in willingness to study. |
|
|
Girardi, P, Greco, et al |
Stat |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We discuss an approach of robust fitting on non-linear regression models, in both frequentist and Bayesian approaches,
which can be employed to model and predict the contagion dynamics of the coronavirus disease 2019 (COVID-19) in Italy. The focus is on the analysis of epidemic data using robust dose–response curves, but the functionality is applicable to arbitrary non-linear
regression models. © 2020 John Wiley & Sons, Ltd. |
|
|
PMC7363362; Lung Scintigraphy Imaging Features in a Young Patient With COVID-19 |
Goetz, C, Fassbender, et al |
Clin Nucl Med |
Clinical data| Données cliniques |
A 31-year-old man developed diarrhea, fatigue, and intermittent fever for 2 weeks. The past few days he had experienced
increasing dyspnea and dry cough. Ambulatory reverse transcriptase-polymerase chain reaction testing was positive for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Because of elevated D-dimer (1.5 mg/L), a lung scintigraphy (V/Q scan) was performed
as SPECT/CT. Ventilation SPECT showed reduced ventilation with central nuclide deposition, whereas perfusion SPECT was inconspicuous, excluding pulmonary embolism. However, the low-dose CT revealed bilateral ground-glass opacities as previously described in
COVID-19. This case highlights the procedure and findings of V/Q scanning (without embolism) in COVID-19. |
|
Goldstein, BA, Cerullo, et al |
JAMA Netw Open |
Healthcare Response | Réponse des soins de santé |
As hospitals begin to recommence elective procedures, it is necessary to have a means to assess how resource intensive
a given case may be. We evaluate the development and performance of a clinical decision support tool to inform resource utilization for elective procedures. Predictive performance was strong with an area under the receiver operator characteristic ranging from
0.76 to 0.93. Sensitivity of the high-risk and medium-risk groupings was set at 95%. The negative predictive value of the low-risk grouping was 99%. We integrated the models into a daily refreshing Tableau dashboard to guide decision-making. |
|
|
Gollwitzer, A, Martel, et al |
Nat Hum Behav |
Public Health response| Interventions de santé publique |
Using the geotracking data of 15 million smartphones per day, we found that US counties that voted for Donald Trump
(Republican) over Hillary Clinton (Democrat) in the 2016 presidential election exhibited 14% less physical distancing between March and May 2020. Partisanship was more strongly associated with physical distancing than numerous other factors, including counties’
COVID-19 cases, population density, median income, and racial and age demographics. Contrary to our predictions, the observed partisan gap strengthened over time and remained when stay-at-home orders were active. |
|
|
Gómez, J, Albaiceta, et al |
Cytokine |
Clinical data| Données cliniques Immunology | Immunologie |
Our aim was to determine whether the IFITM3 rs12252 polymorphism was associated with the risk of developing severe
symptoms of COVID-19 in our population. The IFITM3 rs12252 C allele was a risk factor for COVID-19 hospitalization in our Caucasian population. |
|
|
González-Calatayud, DM, Vargas-Ábrego, et al |
Ann Med Surg (Lond) |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The aim of this study was to report all the surgically intervened patients with suspected or confirmed SARS CoV-2 infection
from April 1 to July 31, 2020, and to estimate their prognosis in the Surgical Therapy Department of a third level hospital in Mexico. 42 patients have been surgically intervened, with a total of 49 surgeries. For Otolaringology and General Surgery, there
were more deceased cases than alive cases; while for Thoracic Surgery, and Obstetrics and Gynecology, there were more alive cases than deceased ones (36% and 0% deceased, respectively), with statistically significant differences (p = 0.014). We identified
an overall mortality rate of 42.8%, with a significant difference between treating departments and type of surgical procedure. This sample of cases undergoing surgery at the beginning of the COVID-19 pandemic can provide clues on relevant results that we must
consider for future cases. |
|
|
Gracia, PV, Caballero, et al |
Ultrasound Obstet Gynecol |
Clinical data| Données cliniques |
This study analyzed data from pregnant women with symptoms of COVID‐19 and positive RT‐PCR for SARS‐CoV‐2 between 8
March and 15 August 2020, who later recovered, as determined by negative clinical assessment or RT‐PCR at least 35 days after the onset of symptoms, delivered at one of four hospitals in the Republic of Panama. Eleven of the 15 (73.3%) patients in this series
presented with PROM, spontaneous labor or maternal complication before 39 weeks of gestation, and only one out of 10 (10.0%) women diagnosed in the second trimester reached 39 weeks of gestation. These findings are of concern as they suggest the possibility
of chronic inflammation with alteration at the placental or membrane level, triggering the culmination of pregnancy. |
|
|
Graham, NR, Whitaker, et al |
Clinical and Translational Immunology |
Clinical data| Données cliniques Immunology | Immunologie |
We assessed serum anti-SARS-CoV-2 RBD-S IgG, IgM and IgA antibodies by a two-step ELISA and neutralising antibodies
in a cross-sectional study of hospitalised COVID-19 patients of varying disease severities. Anti-RBD-S IgG levels were also determined in asymptomatic seropositives. We found equivalent levels of anti-RBD-S antibodies in male and female patients and no age-related
deficiencies even out to 93 years of age. The anti-RBD-S response was evident as little as 6 days after onset of symptoms and for at least 5 weeks after symptom onset. Anti-RBD-S IgG, IgM and IgA responses were simultaneously induced within 10 days after onset,
with anti-RBD-S IgG sustained over a 5-week period. Anti-RBD-S antibodies strongly correlated with neutralising activity. Lastly, anti-RBD-S IgG responses were higher in symptomatic COVID-19 patients during acute infection compared with asymptomatic seropositive
donors. |
|
|
Grechukhina, O, Greenberg, et al |
Am J Obstet Gynecol MFM |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Our study aimed to describe the clinical course of COVID-19, effect of comorbidities on disease severity, laboratory
trends, and pregnancy outcomes of symptomatic and asymptomatic SARS-CoV-2–positive pregnant women. Of the 1567 tested pregnant and postpartum women between March 3, 2020, and May 11, 2020, 9% (n=141) had a positive SARS-CoV-2 result. Severe disease was diagnosed
in 6 cases (4.3%), and there was 1 maternal death. Hypertensive disorders of pregnancy were diagnosed in 22.3% of women (17/77) who delivered after 20 weeks' gestation. Higher levels of C-reactive protein during antepartum coronavirus disease 2019-related
admission were more common in women with worse clinical course; however, this association did not reach statistical significance. Coronavirus disease 2019 in pregnancy may result in severe disease and death. |
|
|
Greene, NH, Kilpatrick, et al |
Am J Obstet Gynecol MFM |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
The objective of this study was to determine whether labor and delivery unit policy modifications we made during the
coronavirus disease 2019 pandemic were associated with differences in outcomes for mothers and newborns. We conducted a retrospective cohort study of all deliveries occurring in our hospital between January 1, 2020, and April 30, 2020. Patients who delivered
in January and February 2020 before labor and delivery unit modifications were instituted were designated as the preimplementation group, and those who delivered in March and April 2020 were designated as the postimplementation group. Postpartum length of
stay was significantly shorter after implementation of labor unit changes related to coronavirus disease 2019. A postpartum stay of 1 night after vaginal delivery occurred in 48.5% of patients in the postimplementation group compared with 24.9% of the preimplementation
group (P<.0001). Postoperative length of stay after cesarean delivery of ≤2 nights occurred in 40.9% of patients in the postimplementation group compared with 11.8% in the preimplementation group (P<.0001). Labor and delivery unit policy modifications to protect
pregnant patients and healthcare providers from coronavirus disease 2019 indicate that maternal and newborn length of stay in the hospital were significantly shorter after delivery without increases in the rate of adverse maternal or neonatal outcomes. |
|
|
Gu, T, Mack, et al |
JAMA network open |
Epidemiology| Épidémiologie |
This study aimed to systematically determine patient characteristics associated with racial/ethnic disparities in COVID-19
outcomes. Findings suggest that preexisting type 2 diabetes or kidney diseases and living in high-population density areas were associated with higher risk for COVID-19 hospitalization. Associations of risk factors with COVID-19 outcomes differed by race. |
|
|
Gu, Y, Zhu, et al |
Asia Pac Psychiatry |
Mental Health |
|
The aims of this study were to evaluate mental health outcomes among patients with COVID‐19 treated in the Fangcang
shelter hospitals and analyze potential risk factors associated with these symptoms, including PTSS, symptoms of anxiety, depression, insomnia, and perceived stress. In this survey study, patients reported high rates of symptoms of posttraumatic stress, anxiety,
depression, insomnia, and perceived stress. Combining with the special environment of the shelter hospitals and patient's psychological needs, the health care workers should give more effective interventions to relieve the patients' stress and improve their
mental symptoms. |
|
|
Guihaire, J, Owyang, et al |
Asaio j |
Clinical data| Données cliniques |
Extracorporeal membrane oxygenation (ECMO) is recognized as organ support for potentially reversible acute respiratory
distress syndrome (ARDS). However, limited resource during the outbreak and the coagulopathy associated with coronavirus disease 2019 (COVID-19) make the utilization of venovenous (VV) ECMO highly challenging. We herein report specific considerations for cannulation
configurations and ECMO management during the pandemic. High blood flow and anticoagulation at higher levels than usual practice for VV ECMO may be required because of thrombotic hematologic profile of COVID-19. Among our first 24 cases (48.8 ± 8.9 years),
17 patients were weaned from ECMO after a mean duration of 19.0 ± 10.1 days and 16 of them have been discharged from ICU. |
|
|
Gulersen, M, Prasannan, et al |
Am J Obstet Gynecol MFM |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study is to determine if any significant placental histopathologic changes occur after the diagnosis
of SARS-CoV-2 infection during pregnancy and whether these changes are correlated with the presence or absence of symptoms associated with the infection. A total of 50 placentas after the diagnosis of maternal SARS-CoV-2 infection and 50 historical controls
were analyzed. There was no statistically significant difference in placental histopathologic characteristics between the groups. |
|
|
Myocardial injury in severe and critical coronavirus disease 2019 patients |
Guo, H, Shen, et al |
J Card Surg |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study is to investigate the effect of myocardial injury on the prognosis of patients with severe or
critical COVID-19. Seventy-four COVID-19 patients were included. CK-MB and interleukin-6 were independent risk factors of increased mechanical ventilation time; myoglobin were the independent predictor of incidence of malignant arrhythmia; age, myoglobin and
NT-proBNP were the independent predictors of mortality. In severe and critical COVID-19 patients, the obvious myocardial injury was observed. Increases of CK-MB, myoglobin, NT-proBNP, interleukin-6, and age were independently associated with poor prognosis
including increased ventilation duration, the incidence of malignant arrhythmia, and mortality. |
|
Gupta, S, Mohindra, et al |
J Dent Res |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Assessed gingival crevicular fluid (GCF) for evidence of SARS-CoV-2 in 33 patients who were deemed to be COVID-19 positive
upon nasopharyngeal sampling. An attempt was also made to comparatively evaluate it with saliva in terms of its sensitivity, as a diagnostic fluid for SARS-CoV-2. Total RNA was extracted using NucliSENS easyMAG (bioMérieux) and eluted in the elution buffer.
Envelope gene (E gene) of SARS-CoV-2 and human RNase P gene as internal control were detected in GCF samples by using the TRUPCR SARS-CoV-2 RT qPCR kit V-2.0 (I) in an Applied Biosystems 7500 real-time machine. A significant majority of both asymptomatic and
mildly symptomatic patients exhibited the presence of the novel coronavirus in their GCF samples. Considering the presence of SARS-CoV-2 RNA in the nasopharyngeal swab sampling as gold standard, the sensitivity of GCF and saliva, respectively, was 63.64% and
64.52%. GCF was found to be comparable to saliva in terms of its sensitivity to detect SARS-CoV-2. Saliva samples tested positive in 3 of the 12 patients whose GCF tested negative, and likewise GCF tested positive for 2 of the 11 patients whose saliva tested
negative. |
|
|
Hadjicharalambous, Demetris, Parlalis, et al |
SSRN- Lancet prepublication |
Mental Health |
|
This study examines the psychological impact of COVID-19 lockdown measures on Cypriots’ mental health and quality of
life in Cyprus. The survey has been carried out in Cyprus with 464 participants. The sample includes 358 women (77%) and 106 men (23%). The results show that 17.1% of the general population experienced keener Social Dysfunction, 8.7% presented Severe Depression,
27.7% had Insomnia / Anxiety, 17.7% had Somatic Symptoms, 15.6% had mental health problems and 37.4% had a low quality of life. Evidence-based findings showed also that participants who have been working regularly and those who stayed home have been more affected
and presented more noticeable somatic symptoms, anxiety and insomnia, health and mental health problems and lower quality of life than participants who have been working from home indeed |
|
|
Life and Attitudes of Slovenians during the COVID-19 Pandemic: The Problem of
Trust |
Hafner-Fink, M, Uhan, et al |
International Journal of Sociology |
Public Health response| Interventions de santé publique |
The article deals with research on the attitudes, reactions and behavior of the Slovenian population in the context
of the COVID-19 pandemic with regard to general trust and trust in the Slovenian government. The results confirm our expectations: there were no significant correlations between general trust in people and adherence to preventive measures. However, we found
statistically significant correlations between trust in government and all aspects of compliance with measures to limit the COVID-19 pandemic. Those with stronger trust in the government followed the measures and reported less difficulty in complying with
them. The results also suggest the relevance of Sztompka's thesis on functional substitutes for trust in a situation where trust is lacking. |
|
COVID-19: US federal accountability for entry, spread, and inequities-lessons for
the future |
Hanage, WP, Testa, et al |
Eur J Epidemiol |
Public health interventions*| Interventions de sant&eacute; publique |
In this article we assess the impact of missteps by the Federal Government in three specific areas: the introduction
of the virus to the US and the establishment of community transmission; the lack of national COVID-19 workplace standards and enforcement, and lack of personal protective equipment (PPE) for workplaces as represented by complaints to the Occupational Safety
and Health Administration (OSHA) which we find are correlated with deaths 16 days later (ρ = 0.83); and the total excess deaths in 2020 to date already total more than 230,000, while COVID-19 mortality rates exhibit severe-and rising-inequities in race/ethnicity,
including among working age adults. |
|
Effects of COVID-19 Pandemic on the Professional Roles and Responsibilities of Health
Educators |
Hancher-Rauch, H, Bishop, et al |
Health Promot Pract |
Healthcare Response | Réponse des soins de santé |
Researchers examined multiple factors that described how health educators’ work priorities and lives have been affected
by COVID-19. Of the 913 respondents, 487 (43%) reported changing work priorities, with 80% of that group (389) sharing that their work priorities shifted focus to COVID-19. |
|
Helm, EE, Kempski, et al |
Rehabilitation Oncology |
Mental Health |
|
This study aimed to assess distress and quality of life (QOL) for women receiving care for breast cancer related impairments
during closure of rehabilitation services due to COVID-19. Fifteen women (age range, 38-76 years) with primary complaints of shoulder stiffness, pain, and lymphedema completed surveys, and 33% received telehealth. Reported distress levels at the time of closure
were significantly higher than self-reported levels at reopening (t14 = 4.69, P = .000). Increases in distress at the time of closure were correlated with reduced physical activity (r = -0.602, P = .018). Reduced levels of distress following return to rehabilitation
were correlated with reduced levels of fatigue (r = 0.575, P = .025). No statistically significant relationships between distress and sleep quality were found. Limitations: Self-report via surveys, recall bias, and the multifactorial characteristics of distress
limit study findings. |
|
|
Helsingen, LM, Refsum, et al |
BMC Public Health |
Public Health response| Interventions de santé publique |
Norway closed educational institutions, and banned sports and cultural activities; Sweden kept most institutions and
training facilities open .We aimed to compare peoples’ attitudes towards authorities and control measures, and perceived impact of the pandemic and implemented control measures on life in Norway and Sweden. Sweden had more trust in the authorities, while Norwegians
reported a more negative lifestyle during the pandemic. |
|
|
Frequency of venous thromboembolism in 6513 patients with COVID-19: a retrospective
study |
Hill, JB, Garcia, et al |
Blood Adv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appear to be at increased risk
for venous thromboembolism (VTE), especially if they become critically ill with COVID-19. Some centers have reported very high rates of thrombosis despite anticoagulant prophylaxis. The electronic health record (EHR) of a New Orleans-based health system was
searched for all patients with polymerase chain reaction-confirmed SARS-CoV-2 infection who were either admitted to hospital or treated and discharged from an emergency department between 1 March 2020 and 1 May 2020. From this cohort, patients with confirmed
VTE (either during or after their hospital encounter) were identified by administrative query of the EHR.: Between 1 March 2020 and 1 May 2020, 6153 patients with COVID-19 were identified; 2748 of these patients were admitted, while 3405 received care exclusively
through the emergency department. In total, 637 patients required mechanical ventilation and 206 required renal replacement therapy. Within the hospitalized cohort, the overall mortality rate was 24.5% and VTE occurred in 86 patients (3.1%). In the 637 patients
who required mechanical ventilation at some point during their hospital stay, 45 developed VTE (7.2%). After a median follow-up of 14.6 days, VTE had been diagnosed in 3 of the 2075 admitted who were discharged alive (0.14%). Among 6153 patients with COVID-19
who were hospitalized or treated in emergency departments, we did not find evidence of unusually high VTE risk. Pending further evidence from prospective, controlled trials, our findings support a traditional approach to primary VTE prevention in patients
with COVID-19. |
|
Great, purposeful expectations: predicting daily purposefulness during the COVID-19
response |
Hill, PL, Klaiber, et al |
Journal of Positive Psychology |
Mental Health |
|
The current studies asked a university (n = 330; Mage = 21.25 years, 77% female) and community (n = 755; Mage = 45.99
years, 89% female) sample to complete seven daily diaries during the first weeks of the COVID-19 response. Each morning, participants reported on how purposeful they expected to be, and each evening, they reported on how purposeful they felt and on daily events.
Participants tended to overestimate their daily purposefulness from morning to evening, with students being more discrepant. Higher neuroticism and more stressors (both COVID-related and not) predicted greater discrepancies, while positive events and support
provisions were associated with less discrepancy. |
|
Ho, BE, Ho, et al |
IDCases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We report a familial cluster of 5 presumed and 2 confirmed COVID-19 cases, all of whom reported one or more GI symptoms
and 5 of whom reported sensory symptoms of anosmia/hyposmia, ageusia/hypogeusia, and/or dysgeusia. This frequency of GI symptoms is high relative to currently available epidemiological reports, which also infrequently report on sensory symptoms. COVID-19 exhibits
wide variation in duration, severity, and progression of symptoms, even within a familial cluster. |
|
|
Hogan, C, Atta, et al |
Int J Emerg Med |
Public Health response| Interventions de santé publique |
This was a survey of the general non-healthcare-worker USA population regarding their knowledge and attitudes toward
the COVID-19 pandemic. Almost everyone practiced social distancing. Women were significantly more likely to be worried about contracting the virus than men (65% vs. 43%, p = 0.0272). There was also a linear trend with age, with older Americans being more worried
about contracting the virus. |
|
|
Hoshiyama, T, Wada, et al |
Intern Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Describe the clinical features and clinical course of individuals diagnosed with asymptomatic SARS-CoV-2 infection
or mild COVID-19. The study participants consisted of 7 crewmembers of the passenger cruise-liner, Diamond Princess, who were admitted to hospital after becoming infected with SARS-CoV-2 aboard the ship. The median age of the 7 patients, of whom 4 were male
and 3 were female, median age was 39 years. On admission, none of them had fever, but 4 had a cough. None of them showed any signs of organ damage on laboratory testing. Chest X-ray showed pneumonia in one individual, which resolved spontaneously, while the
other 6 had normal chest X-ray findings. Culture of throat swabs and sputum samples revealed that 4 patients had bacterial upper respiratory infections (Haemophilus influenzae, Klebsiella pneumoniae, and Staphylococcus aureus). The period from a positive PCR
test to negative conversion ranged from 5 to 13 days, with a median of 8 days. |
|
|
Howe, KL, Achuthan, et al |
Nucleic Acids Res |
Coronavirology| Coronavirologie |
The Ensembl project annotates genomes and disseminates genomic data for vertebrate species. Here, we present recent
Ensembl developments including two new website portals. Ensembl Rapid Release is designed to provide core tools and services for genomes as soon as possible and has been deployed to support large biodiversity sequencing projects. Our SARS-CoV-2 genome browser
integrates our own annotation with publicly available genomic data from numerous sources to facilitate the use of genomics in the international scientific response to the COVID-19 pandemic. |
|
|
Hsieh, Chung-Han |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
At the time of writing, the ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
had already resulted in more than thirty-two million cases infected and more than one million deaths worldwide. Given the fact that the pandemic is still threatening health and safety, it is in the urgency to understand the COVID-19 contagion process and know
how it might be controlled. With this motivation in mind, in this paper, we consider a version of a stochastic discrete-time Susceptible-Infected-Recovered-Death~(SIRD)-based epidemiological model with two uncertainties: The uncertain rate of infected cases
which are undetected or asymptomatic, and the uncertain effectiveness rate of control. Our aim is to study the effect of an epidemic control policy on the uncertain model in a control-theoretic framework. We begin by providing the closed-form solutions of
states in the modified SIRD-based model such as infected cases, susceptible cases, recovered cases, and deceased cases. Then, the corresponding expected states and the technical lower and upper bounds for those states are provided as well. Subsequently, we
consider two epidemic control problems to be addressed: One is almost sure epidemic control problem and the other average epidemic control problem. Having defined the two problems, our main results are a set of sufficient conditions on a class of linear control
policy which assures that the epidemic is "well-controlled"; i.e., both of the infected cases and deceased cases are upper bounded uniformly and the number of infected cases converges to zero asymptotically. Our numerical studies, using the historical COVID-19
contagion data in the United States, suggest that our appealingly simple model and control framework can provide a reasonable epidemic control performance compared to the ongoing pandemic situation. |
|
|
Hu, N, Li, et al |
Frontiers in Psychology |
Mental Health |
|
The purpose of this study was to explore the relationship between the family environment and the emotional state of
the medical staff members during the COVID-19 outbreak. First, a higher prevalence of anxiety (39%) and depressive (33%) symptoms were confirmed among the medical staff. Second, the symptoms of anxiety and depression were negatively correlated with the dimensions
of cohesion and expressiveness and positively correlated with the dimensions of conflict in the FES-CV scale. Third, self-efficacy significantly mediated the association between the family environment and anxiety symptoms (P < 0.001) as well as the family
environment and depressive symptoms (P < 0.001). These findings show that a negative family environment was the main predictor of symptoms of anxiety and depression in the medical staff during the COVID-19 outbreak. Furthermore, we found that self-efficacy
played a critical mediating role between the family environment and the symptoms of anxiety and depression. |
|
|
Huang, L, Zhao, et al |
JACC Cardiovasc Imaging |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Evaluated cardiac involvement in patients recovered from coronavirus disease-2019 (COVID-19) using cardiac magnetic
resonance (CMR). Twenty-six patients recovered from COVID-19 who reported cardiac symptoms and underwent CMR examinations were retrospectively included. Fifteen patients had abnormal CMR findings on conventional CMR sequences: myocardial edema was found in
14 patients and late gadolinium enhancement (LGE) was found in 8 patients. Decreased right ventricle functional parameters including ejection fraction, cardiac index, and stroke volume/body surface area were found in patients with positive conventional CMR
findings. Using quantitative mapping, global native T1, T2, and extracellular volume (ECV) were all found to be significantly elevated in patients with positive conventional CMR findings, compared with patients without positive findings and controls (median:
native T1 1,271 ms vs. 1,237 ms vs. 1,224 ms; mean T2 42.7 ms vs. 38.1 ms vs. 39.1 ms). |
|
|
Clinical data of early COVID-19 cases receiving extracorporeal membrane oxygenation
in Wuhan, China |
Huang, S, Xia, et al |
Journal of clinical anesthesia |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
ECMO (extracorporeal membrane oxygenation) application in 3 severely ill COVID-19 patients. Poor prognoses probably
related to their age, underlying diseases, and COVID-19's evolution. |
|
Ide, S, Morioka, et al |
Intern Med |
Clinical data| Données cliniques |
A previously healthy 68-year-old Japanese man working in a fish market presented with fever and dyspnea at our hospital.
He was then hospitalized after having been diagnosed with coronavirus disease (COVID-19). In the outpatient follow-up one month after discharge, he reported white horizontal nail striae and sunken nails, clinically defined as leukonychia and Beau’s lines.
Both Beau’s lines and leukonychia may be a significant clinical presentation of COVID-19. |
|
|
Inagaki, Hiroko, Saito, et al |
bioRxiv |
Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
We evaluated the inactivating effect of ozone water against SARS-CoV-2 by its concentration and exposure time. The
reduction rates of virus titer after 5 sec treatment with ozone concentrations of 1, 4, 7, and 10 mg/L were 81.4%, 93.2%, 96.6%, and 96.6%, respectively. No further decrease in virus titer was observed by the extended exposure time over 5 sec. High-concentration
ozone water was considered to be effective in promptly inactivating SARS-CoV-2 virus. |
|
|
Telemedicine for postoperative follow-up, virtual surgical clinics during COVID-19
pandemic |
Irarrázaval, MJ, Inzunza, et al |
Surg Endosc |
Healthcare Response | Réponse des soins de santé |
The aim of the present prospective study is to compare the use of telemedicine clinics to in-person follow-up for postoperative
care after gastrointestinal surgery during COVID-19 outbreak. Among 219 patients who underwent abdominal surgery, 106 (48%) had their postoperative follow-up using telemedicine. There were no differences in age, gender, ASA score, and COVID-19 positive rate
between groups. Morbidity rate for telemedicine and in-person group was 5.7% and 8%, (P = 0.50). Only 2.8% of patients needed an in-person visit following the telemedicine consult, and 1.9% visited the emergency department. In the current pandemic, telemedicine
follow-up can be safely and effectively performed in selected surgical patients. |
|
Ishii, M, Terai, et al |
J Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective multicenter study evaluated the characteristics and prognostic factors of 345 patients with COVID-19,
who were admitted to either Keio University Hospital or one of 13 community hospitals located in the Greater Tokyo Area from February 1 to June 19, 2020. The aim is to investigate the similarity in risk factors to those previously reported in an aging country
such as Japan. We performed multivariate analysis of risk factors for death associated with SARS-CoV-2 infection, and factors, including chronic kidney disease (OR 5.74), older age (OR 5.43), and hyperuricemia (OR 3.60), were independently associated with
death resulting from COVID-19. |
|
|
Lung ultrasound in early SARS-CoV-2 pneumonia and the LUS-CoV criteria |
Jalil, BA, Khan, et al |
Baylor University Medical Center Proceedings |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Of 69 patients who had lung ultrasound images saved and were included in the analysis, 36 were positive for SARS-CoV-2.
Multifocal confluent B-lines, pleural irregularities, and the absence of moderate or large pleural effusions were the predominant pattern observed in most (86%) of SARS-CoV-2–positive patients. We evaluated the accuracy of the above criteria (LUS-CoV) and
report a high sensitivity (91%) and specificity (86%) for SARS-CoV-2 pneumonia. In conclusion, a characteristic sonographic pattern of multifocal confluent B-lines with irregular pleural markings was seen on LUS in patients with SARS-CoV-2 pneumonia. |
|
Jallab, HR |
European Journal of Molecular and Clinical Medicine |
Clinical data| Données cliniques |
The study aimied to evaluate the clinical outcome of a sample of symptomatic patients with COVID-19 admitted to Al-Diwaniyah
teaching hospital at Al-Diwaniyah Province in the mid-Euphrates region of Iraq. This cross sectional study was conducted from February 2nd 2020 till May 2nd 2020. The study included 11 patients, 6 males and 5 females with an age range of 19 to 60 years. The
major manifestations reported in all cases were fever, headache and upper respiratory tract symptoms followed by sudden onset shortness of breath. Five cases are reported as cured, 5 are still under clinical observation receiving supportive treatment, and
1 case died. |
|
|
Jamshidi, S, Baniasad, et al |
International Journal of Environmental Research and Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
We evaluated the relationship between COVID-19 and weather (considering equivalent temperature that combines the effect
of humidity and air temperature) with particular consideration of urban density, mobility, homestay, demographic information, and mask use within communities. Our findings highlighted the importance of considering spatial and temporal scales for interpreting
the weather/climate impact on the COVID-19 spread and spatiotemporal lags between the causal processes and effects. On global to regional scales, we found contradictory relationships between weather and the transmission rate, confounded by decentralized policies,
weather variability, and the onset of screening for COVID-19, highlighting an unlikely impact of weather alone. At a finer spatial scale, the mobility index (with the relative importance of 34.32%) was found to be the highest contributing factor to the COVID-19
pandemic growth, followed by homestay (26.14%), population (23.86%), and urban density (13.03%). The weather by itself was identified as a noninfluential factor (relative importance < 3%). The findings highlight that the relation between COVID-19 and meteorology
needs to consider scale, urban density and mobility areas to improve predictions. |
|
|
Dried SARS-CoV-2 virus maintains infectivity to Vero E6 cells for up to 48 h |
Jang, H, Ross, et al |
Veterinary microbiology |
Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
Our findings warrants that the drying cannot replace the surface disinfection to prevent transmission via common vehicle
or nosocomial infection. |
|
Jeganathan, S, Prasannan, et al |
Am J Obstet Gynecol MFM |
Healthcare Response | Réponse des soins de santé |
This study aimed to describe patient and provider attitudes toward telehealth for the delivery of high-risk obstetrical
care in a large healthcare system with both urban and suburban settings and to determine whether the implementation of a telehealth model improves patient adherence to scheduled appointments in this patient population. A total of 91 patient surveys and 33
provider surveys were analyzed. Overall, 86.9% of patients were satisfied with the care they received and 78.3% would recommend telehealth visits to others. Notably, 87.8% of providers reported having a positive experience using telehealth, and 90.9% believed
that telehealth improved patients’ access to care. |
|
|
Jerome, D, Pietrosanu, et al |
J Public Health (Oxf) |
Public Health response| Interventions de santé publique |
This study examines physician knowledge of the ABTraceTogether smartphone app and practice patterns in relation to
the app. We conducted a cross-sectional self-administered online English language survey of physicians and medical students in Alberta, Canada. The survey received 317 responses. 96% of participants were aware of the app but only 27% had recommended the app
to patients. The most common reason provided for not downloading or recommending the app was that participants had security concerns about the app. |
|
|
Jones, A, Strigul, et al |
Chaos, Solitons and Fractals |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We hypothesize that the unpredictability of the pandemic could be a fundamental property if the disease spread is a
chaotic dynamical system. Our mathematical examination of COVID-19 epidemic data in different countries reveals similarity of this dynamic to the chaotic behavior of many dynamics systems, such as logistic maps. We conclude that the data does suggest that
the COVID-19 epidemic demonstrates chaotic behavior, which should be taken into account by public policy makers. Furthermore, the scale and behavior of the epidemic may be essentially unpredictable due to the properties of chaotic systems, rather than due
to the limited data available for model parameterization. |
|
|
COVID-19-related anxiety disorder in Iraq during the pandemic: an online cross-sectional
study |
Karim, SK, Taha, et al |
Middle East Current Psychiatry |
Mental Health |
|
In Iraq, during the COVID-19 pandemic, nearly half of the respondents have health anxiety. Being female, younger ages,
holding an academic degree, or being a college student are associated with more prominent degrees of anxiety. |
|
Multicenter study evaluating the impact of COVID-19 outbreak on dermatology outpatients
in Turkey |
Kartal, SP, Çelik, et al |
Dermatol Ther |
Healthcare Response | Réponse des soins de santé |
The study aimed to document the effect of pandemic on dermatology outpatient clinics in Turkey. 15 tertiary hospitals
from 13 provinces were included in the study, which was conducted between January 12 and May 12, 2020. The pandemic caused a noteworthy reduction in the number of patients accessing dermatological care. The pandemic caused significant changes in the frequency
of a wide range of dermatological diseases. |
|
A cohort study of 30 day mortality after NON-EMERGENCY surgery in a COVID-19 cold
site |
Kasivisvanathan, V, Lindsay, et al |
International Journal of Surgery |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
It is safe to continue cancer and urgent surgery during the COVID-19 pandemic with appropriate service reconfiguration. |
|
Covid-19 positivity affects outcome of cardiac surgical patients |
Katsiampoura, A, Perozo, et al |
J Card Surg |
Clinical data| Données cliniques |
In this report we describe the clinical presentation, laboratory findings and outcomes of four patients that were referred
for urgent cardiothoracic intervention and tested positive for COVID‐19. Our study shows that these patients have very high mortality, whereas prevention and preoperative screening is required in preventing nosocomial spreading of the disease. |
|
Kayral, İE, Buzrul, et al |
Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie
clinique |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
COVID-19 infection data of Emerging 7 (E7) countries, namely Brazil, China, India, Indonesia, Mexico, Russia, and Turkey
were described by an empirical model or a special case of this empirical model. Near-future forecasts were also performed. Moreover, the causalities between the Stringency Index's indicators and total cases in E7 countries in COVID-19 period were examined.
Countries were grouped as "stationary," "transition," and "exponential" based on the data and model fits. The proposed models produced good fits to the COVID-19 data of E7 countries and it was possible to predict the number of cases in the near future. Some
policies to control total cases in E7 countries were also proposed in the final phase of this study based on the findings and forecasting in these countries. |
|
|
Kerr, B, Pharithi, et al |
Int J Cardiol Heart Vasc |
Healthcare Response | Réponse des soins de santé |
We set out to address the physician and patient opinion of remote management of heart failure (HF) during COVID-19.
Results demonstrate reasonable patient / physician satisfaction with STA, and provides some direction on how this care platform might be sustained beyond the COVID crisis. |
|
|
Khan, E, Lal, et al |
Pakistan Journal of Medical Sciences |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We performed percutaneous dilation tracheostomy in three clinically challenging COVID-19 patients in our ICU and developed
guidelines aiming to minimise aerosolisation during and after the tracheostomy procedure to safeguard healthcare workers. The decision of surgical or percutaneous tracheostomy should be dependent on the experience of the tracheostomy performer, health-care
worker safety, resource availability, and patient-centred care. We believe our modified strategic approach of brief bronchoscopy, minimum PEEP and gas flows and stepwise planned approach for PCDT offers an extra level of safety to healthcare workers. |
|
|
Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models |
Khoury, DS, Wheatley, et al |
Nat Rev Immunol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
In this study, we analyse a selection of existing assays for measuring antibody-mediated virus neutralization and animal
models of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and provide a framework for comparing results between studies and reconciling observed differences in the effects of interventions. Finally, we propose how we might optimize
these assays for better comparison of results from in vitro and animal studies to accelerate progress. |
|
Kim, SK, Kim, et al |
J Korean Med Sci |
Epidemiology| Épidémiologie Transmission Infection Prevention and Control/ Prévention
et contrôle des infections (IPAC/PCI) |
There were two rallies of medical students and trainee doctors, where 9,000 participants gathered. We performed polymerase
chain reaction (PCR)-based universal screening for the participants using pooling at a tertiary care hospital. Around 609 (94%) of 646 participants underwent PCR tests for severe acute respiratory syndrome coronavirus 2; all of them tested negative. Our data
suggested low transmission rates in open air mass gatherings when appropriate personal protective practices were followed. |
|
|
Kim, YJ, Cho, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
This study utilizes the Theory of Planned Behavior (TPB) variables-including attitude, subjective norms, and perceived
behavioral control-to understand the relationship between mask-wearing behavior and physical/non-physical leisure activity participation in Koreans as well as the tendencies behind mask-wearing intentions within leisure activities. First, a difference in mask-wearing
intention based on physical and non-physical leisure activities was identified; second, attitudes and perceived behaviors were considered in light of the dangers posed by COVID-19. It was found that control influences the tendency of intention to wear a mask
depending on whether the group was engaged in physical or non-physical activity. Therefore, it can be stated that mask-wearing must be mandatory during physical and non-physical activities owing to respiratory diseases such as COVID-19. |
|
|
Kimhi, S, Eshel, et al |
International Journal of Environmental Research and Public Health |
Mental Health |
|
A longitudinal study was conducted to identify levels of distress, resilience, and the subjective well-being of the
population. The study is based on two repeated measurements conducted at the end of the pandemic’s “first wave” and the beginning of the “second wave” on a sample (n = 906) of Jewish Israeli respondents. Results indicated the following: (a) a significant increase
in distress indicators, with effect sizes of sense of danger, distress symptoms, and perceived threats (Cohen’s d 0.614, 0.120, and 0.248, respectively); (b) a significant decrease in resilience indicators, with effect sizes of individual, community, and national
resilience (Cohen’s d 0.153, 0.428, and 0.793, respectively); and (c) a significant decrease in subjective well-being indicators with effect sizes of well-being, hope, and morale (Cohen’s d 0.116, 0.336, and 0.199, respectively). |
|
|
Klang, Shmuel, Mann, et al |
Research Square prepub |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
Taffix is approved for use in Europe and Israel. In vitro studies demonstrated that Taffix blocks viruses (including
SARS- CoV-2) from infecting human cells (<99% ). In a prospective users survey, 243 members of a Jewish ultra-orthodox synagogue community in Bney Brak that participated. 83 collected and used Taffix throughout Rosh Hashana prayers and for the following two
weeks (intention to treat group, ITT) . 2/83 (2.4%) of the Taffix users and 16/160 (10%) of the Taffix non users were infected. The odds ratio for SARS-CoV-2 infection in Taffix users were 0.22 (0.05-0.99, Mid P exact =0.028), a reduction of 78% (95%CI 1%-95%)
in odds of infection. No side effects were reported. To our knowledge this is the first time that any measure to prevent infection in SARS-CoV-2 virus, beyond the use of masks. was proven effective. |
|
|
Sleep quality during the COVID-19 pandemic: not one size fits all |
Kocevska, D, Blanken, et al |
Sleep medicine |
Clinical data| Données cliniques Mental Health |
|
The current study aimed to elucidate effects of the COVID -19 pandemic on sleep quality. Participants (n = 667) of
the Netherlands Sleep Registry (NSR) were invited for weekly online assessment of the subjective severity of major stressors, insomnia, sleep times, distress, depression, and anxiety using validated scales. Our data suggest COVID-19 lockdown measures more
often worsened sleep complaints in pre-pandemic good sleepers, whereas a subset of people with pre-pandemic severe insomnia symptoms underwent a clinically meaningful alleviation of symptoms in our sample. |
|
Miocarditis in patients with covid-19 confirmed by immunohistochemical |
Kogan, EA, Berezovskiy, et al |
Kardiologiya |
Clinical data| Données cliniques |
The aim of this study was to demonstrate a possibility of lymphocytic myocarditis and to study its morphological features
in patients with the novel coronavirus infection (COVID-19) with a severe course. A possibility for development of lymphocytic viral myocarditis in COVID-19 was confirmed morphologically and immunohistochemically. Specific features of myocarditis in COVID-19
include the presence of coronaritis and a possible combination of myocarditis with lymphocytic endo- and pericarditis. |
|
33091289; COVID-19 Experience in a Wisconsin Academic Medical Center |
Kolinski, JM, Sundararajan, et al |
WMJ : official publication of the State Medical Society of Wisconsin |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We performed a retrospective analysis of data obtained for COVID-19 patients admitted from March 14, 2020, through
April 19, 2020. One hundred sixty-eight patients were admitted. Outcomes measured include time in the intensive care unit (53%), mechanical ventilation (18%), and death (19%). ICU patients had higher rates of diabetes, obesity, and higher inflammatory markers.
The majority of patients admitted were African American (68%). |
|
König, S, Hohenstein, et al |
Eur J Heart Fail |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Whether hospitalization rates and in-hospital mortality were affected by the pandemic in patients with acute symptomatic
heart failure (HF) was investigated in this study. Administrative data provided by 67 German Helios hospitals were examined for patients with main discharge diagnosis of HF using ICD-codes. Urgent hospital admissions per day were compared for a study period
(March 13th-May 21th, 2020) with control intervals in 2020 (January 1st-March 12th) and 2019 (March 13th-May 21th), resulting in a total of 13 484 patients excluding all patients with laboratory-proven COVID-19 infection. The number of admissions per day was
lower in the study period compared to the same year (IRR 0.69, 95%CI 0.67-0.73, p < 0.01) and the previous year control group (IRR 0.73, 95%CI 0.70-0.76, p < 0.01). The data showed a significant reduction of urgent hospital admissions for HF with increased
case-severity and concomitant in-hospital mortality during the COVID-19 pandemic in Germany. |
|
|
Kovacs, SK, Palmer, et al |
WMJ : official publication of the State Medical Society of Wisconsin |
Epidemiology| Épidémiologie |
The authors searched the institutional laboratory information system for consecutive patients who were tested for SARS-CoV-2
by RT-PCR of a nasopharyngeal specimen over a 1-month period. Characteristics and results of patients who received a single or multiple tests were documented and analyzed. In a population of patients with a low positive rate for SARS-CoV-2 by nasopharyngeal
RT-PCR testing, repeat nasopharyngeal testing of negative patients who have persistent symptoms still yields a negative result in 96% of the cases. |
|
|
33079199; Factors Associated With US Adults' Likelihood of Accepting COVID-19
Vaccination |
Kreps, S, Prasad, et al |
JAMA network open |
Public Health response| Interventions de santé publique |
To examine the factors associated with survey participants' self-reported likelihood of selecting and receiving a hypothetical
COVID-19 vaccine. In this survey study of US adults, vaccine-related attributes and political characteristics were associated with self-reported preferences for choosing a hypothetical COVID-19 vaccine and self-reported willingness to receive vaccination.
These results may help inform public health campaigns to address vaccine hesitancy when a COVID-19 vaccine becomes available. |
|
Kumar Vishvakarma, V, Nand, et al |
Comput Toxicol |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
The authors used previously synthesized compounds, xanthene-triazole-chloroquinoline/ xanthene-chloroquinoline hybrids
for the inhibition of the main protease of the SARS-CoV-2 via using computational tools, molecular docking and ADMET properties. COMD AP3 was found to be the best candidate from the library of the designed molecules. It has acceptable solubility along with
the distribution and metabolism property. ADMET results corroborate the docking result towards the potency of COMP AP3. |
|
|
An Intelligent Prediction Model of COVID-19 in India using Hybrid Epidemic
Model |
Kumar, M, Bareja, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This article presents the current situation of COVID 19 spread in India and how it is impacted by various measures
taken by the administration. Hybrid epidemic susceptible-infected recovered model is used to make predictions at every stage of coronavirus. The basic reproduction number R0, is constructed using a logistic function. An improved or hybrid epidemic model is
build based on various other factors to build a logistic infection rate to analyse the patterns and trend in the data. Secondly, ICU beds and ventilators available per 100, 000 inhabitants is also taken in account for critical. Also, the timeline for changing
the stage of coronavirus is used from various reliable resources. Moreover, in comparison with the traditional SIR models, accuracy in the predictions has significantly increased with the R2 value of 96.8 percent for the future days in India. |
|
Monitoring Novel Corona Virus (COVID-19) Infections in India by Cluster Analysis |
Kumar, S |
Annals of Data Science |
Epidemiology| Épidémiologie |
In the current study, we apply cluster analysis, one of the data mining techniques to classify real groups of infectious
disease “novel corona virus disease (COVID-19)” data set of different states and union territories (UTs) in India according to their high similarity to each other. The results obtained permit us to have a sense of clusters of affected Indian states and UTs.
The main objective of clustering in this study is to optimize monitoring techniques in affected states and UTs in India which will be very valuable to the government, doctors, the police and others involved in understanding seriousness of the spread of novel
coronavirus (COVID-19) to improve government policies, decisions, medical facilities (ventilators, testing kits, masks etc.), treatment etc. to reduce number of infected and deceased persons. |
|
Kwarteng, Alexander, Asiedu, et al |
Research Square prepub |
Coronavirology| Coronavirologie Immunology | Immunologie |
Recently, several mutations in the SARS-CoV-2 genome have been identified and reported. However, little is currently
known about the influence of these mutations on the infectivity, transmissibility and antigenicity of the virus. Here, using an integrative computational approach, we characterized the G476S variant of SARS-CoV-2 focusing on interactions with ACE-2 and neutralizing
antibodies. The substitution of Gly-476 to Ser-476 in the SARS-CoV-2 Receptor-binding domain (RBD) largely affected the structural dynamics of the S-protein leading to significant influence on the interactions with ACE-2 and neutralizing antibodies. Structural
properties of the S-protein such as conformation changes, residual fluctuations and residue surface area largely varied between the wild-type and G476S variant, especially in the RBD. Analyses of the interaction energies between S-protein and ACE-2 suggest
that the G476S variant may have enhanced interactions with ACE-2 compared to the wild-type. The G476S variant was found to have weaker interactions with the neutralizing antibody H014 compared to the wild-type. Collectively, our findings have implications
for the infectivity and antigenicity of the G476S variant of SARS-CoV-2. |
|
|
Kwok, CS, Gale, et al |
Circ Cardiovasc Interv |
Healthcare Response | Réponse des soins de santé |
The objective of the study was to evaluate changes in percutaneous coronary intervention (PCI) practice in England
by analyzing procedural numbers, changes in the clinical presentation, and characteristics of patients and their clinical outcomes during the coronavirus disease 2019 (COVID-19) pandemic. The lockdown in England has resulted in a significant decline in PCI
procedures. Fewer patients underwent PCI for stable angina. This enabled greater capacity for urgent and emergency cases, and a reduced length of stay was seen for such patients. Significant changes in the characteristics of patients towards a lower risk phenotype
were observed, particularly for non–ST-segment–elevation myocardial infarction, reflecting a more conservative approach to this cohort. |
|
|
Lai, R, Tan, et al |
J Occup Environ Med |
Mental Health |
|
We explore the level and influencing factors of help-seeking behavior of returning to work in healthcare workers (HCWs).
HCWs sought help with respect to COVID-19-diagnosized problem most. Help-seeking intention, problems encountered after return, test for return, work condition during COVID-19, relatives or friends diagnosed or suspected as COVID-19, and socio-demographic characteristics
such as occupation, education, title, and marriage status are predictors of help-seeking behavior. |
|
|
A 67-Year-Old Woman with Sudden Hearing Loss Associated with SARS-CoV-2 Infection |
Lamounier, P, Franco Gonçalves, et al |
Am J Case Rep |
Clinical data| Données cliniques |
Report a case of sudden hearing loss in a patient with COVID-19 pneumonia due to SARS-CoV-2 infection. A 67-year-old
woman with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as confirmed by reverse transcription-polymerase chain reaction (RT-PCR) testing from nasopharyngeal and oropharyngeal swabs, was examined. She experienced sudden hearing loss in her
right ear and disabling tinnitus. She underwent combined corticosteroid therapy (oral and intratympanic), resulting in an isolated improvement of 250 kHz in the right ear (from 60 dB, the threshold became 15 dB) and of 4, 6, and 8 kHz in the left ear (from
35 dB, 20 dB, and 35 dB, the thresholds became 15 dB, 5 dB and 20 dB, respectively). |
|
Epidemic Spreading in a Social Network with Facial Masks wearing Individuals |
Lee, Duan-Shin, Zhu, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique |
In this paper, we present a susceptible-infected-recovered (SIR) model with individuals wearing facial masks and individuals
who do not. The disease transmission rates, the recovering rates and the fraction of individuals who wear masks are all time dependent in the model. We develop a progressive estimation of the disease transmission rates and the recovering rates based on the
COVID-19 data published by John Hopkins University. We determine the fraction of individual who wear masks by a maximum likelihood estimation, which maximizes the transition probability of a stochastic susceptible-infected-recovered model. The transition probability
is numerically difficult to compute if the number of infected individuals is large. We develop an approximation for the transition probability based on central limit theorem and mean field approximation. We show through numerical study that our approximation
works well. We develop a bond percolation analysis to predict the eventual fraction of population who are infected, assuming that parameters of the SIR model do not change anymore. We predict the outcome of COVID-19 pandemic using our theory. |
|
Patterns of Delaying Surgery for Breast Cancer During the COVID-19 Outbreak in Daegu,
South Korea |
Lee, J, Jung, et al |
Frontiers in Surgery |
Healthcare Response | Réponse des soins de santé |
This study investigated the patterns of delaying surgery for breast cancer during the COVID-19 outbreak in South Korea
and evaluated factors that may have affected the decision to delay surgery. In patients belonging to the delaying surgery group, the mean delay period was 15.9 (standard deviation SD], ±10.9) days. Patients in the non-delaying surgery group were relatively
younger (p = 0.003), single (p = 0.038), had planned mastectomy (p = 0.041), received needle biopsy for diagnosis (p = 0.021), and had a higher clinical N stage (p = 0.049) and multifocal lesions of breast cancer (p = 0.020). However, there were no significant
differences in terms of the pathological T and N stages between the two groups. |
|
Remdesivir for the Treatment of Severe COVID-19: A Community Hospital's Experience |
Lee, S, Santarelli, et al |
J Am Osteopath Assoc |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The objective of this study was to describe the clinical outcomes of COVID-19 patients following treatment with remdesivir
at a community hospital. The mean length of stay for patients who received remdesivir was 10.09 days and the mean duration of oxygen therapy was 9.42 days. A total of 14 (18.4%) patients given remdesivir were admitted to the intensive care unit (ICU) with
an mean length of stay of 9.29 days. Women administered remdesivir were more likely to be admitted to the ICU. The mortality rate was 14 patients (18.4%), with no statistically significant difference observed between men and women. No significant difference
was seen amongst sexes for duration of oxygen therapy or length of stay. There was no statistically significant difference in pooled racial groups (white vs nonwhite) for in-hospital mortality, number admitted to the ICU, days spent in the ICU, duration of
oxygen use, or length of stay. |
|
Lee, Sungyul, Lee, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, we developed and applied a robust ribonucleoprotein capture protocol to uncover the SARS-CoV-2 RNA interactome.
We report 109 host factors that directly bind to SARS-CoV-2 RNAs including general antiviral factors such as ZC3HAV1, TRIM25, and PARP12. Applying RNP capture on another coronavirus HCoV-OC43 revealed evolutionarily conserved interactions between viral RNAs
and host proteins. Network and transcriptome analyses delineated antiviral RBPs stimulated by JAK-STAT signaling and proviral RBPs responsible for hijacking multiple steps of the mRNA life cycle. By knockdown experiments, we further found that these viral-RNA-interacting
RBPs act against or in favor of SARS-CoV-2. |
|
|
Lee, YY, Park, et al |
Biomaterials |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
As symptoms progress in patients with SARS-CoV-2 sepsis, elevated amounts of cell-free DNA (cfDNA) are produced, which
in turn induce multiple organ failure in these patients. In this study, we generated recombinant DNase-1-coated polydopamine-poly(ethylene glycol) nanoparticulates (named long-acting DNase-1).Our findings suggest that exogenously administered long-acting nanoparticulate
DNase-1 can effectively reduce cfDNA levels and may be used as a potential therapeutic intervention. |
|
|
Status epilepticus admissions during the COVID-19 pandemic in Salzburg-A population-based
study |
Leitinger, M, Poppert, et al |
Epilepsia |
Healthcare Response | Réponse des soins de santé |
Several emergencies were admitted less frequently to the hospital during the coronavirus disease 2019 (COVID‐19) pandemic.
To investigate whether this also occurred with status epilepticus (SE) we compared admissions due to first SE from March to April 2020 (“Time of COVID,” TOC) with January to February 2020 (“pre‐COVID,” preCOV). Admission numbers did not differ significantly
from previous years. Estimated adjusted incidence was in line with a recent 5‐year epidemiological study in Salzburg. However, a trend toward less‐frequent nonconvulsive SE (NCSE) and loss of female predominance were indirect hints of underdiagnosing SE. |
|
Optimal containment control strategy of the second phase of the covid-19 lockdown in morocco |
Lhous, M, Zakary, et al |
Applied Sciences (Switzerland) |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
This work investigates the optimal control of the second phase of the COVID-19 lockdown in Morocco. The model consists
of susceptible, exposed, infected, recovered, and quarantine compartments (SEIRQD model), where we take into account contact tracing, social distancing, quarantine, and treatment measures during the nationwide lockdown in Morocco. First, we present different
components of the model and their interactions. Second, to validate our model, the nonlinear least-squares method is used to estimate the model’s parameters by fitting the model outcomes to real data of the COVID-19 in Morocco. Next, to investigate the impact
of optimal control strategies on this pandemic in the country. We also give numerical simulations to illustrate and compare the obtained results with the actual situation in Morocco. |
|
A New Screening Method for COVID-19 based on Ocular
Feature Recognition by Machine Learning Tools |
Li, Feng, Xue, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We constructed a machine-learning model based on ocular surface features and proposed a new screening method for COVID-19.
A retrospective study of analyzing 446 subjects and a prospective study with 128 subjects were conducted with this method. : The performance of detecting COVID-19 patients in the retrospective study have achieved an AUC of 0.999 (95% CI, 0.997-1.000), with
a sensitivity of 0.982 (95% CI, 0.954-1.000), and a specificity of 0.978 (95% CI, 0.961-0.995). And in the prospective study, our model performance on COVID-19 has achieved an AUC of 0.980 (95% CI, 0.970-0.990), with a sensitivity of 0.770 (95% CI, 0.694-0.846),
and a specificity of 0.973(95% CI, 0.957-0.989). This deep learning method based on eye-region images demonstrates the high accuracy to distinguish COVID-19 patients. |
|
CT Scan Synthesis for Promoting Computer-Aided Diagnosis Capacity of COVID-19 |
Li, H, Hu, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
A general-purpose solution is proposed to synthesize COVID-19 CT scans from non-COVID-19 data for providing high-quality
negative-positive paired CT scans. Particularly, we introduce an elastic registration algorithm of CT images to manufacture paired training data. Then, a conditional Generative Adversarial Networks (GANs) based image-to-image translation model is implemented
to synthesize COVID-19 CT scans from non-COVID-19 data. The effectiveness of our proposed algorithm used in COVID-19 aided diagnosis is verified in the experiments, and the identification and detection capacities of the classification models have been enhanced
with the generated CT scans. Specifically, the precise lesion location is achieved by the generated data with a weakly supervised algorithm of class activation mapping (CAM). The model and code of this paper are publicly available at https://github.com/lihengbit/Synthesis-of-COVID-19-CT-Scan. |
|
Li, H, Xiao, et al |
EClinicalMedicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The current study aimed to determine the impact of SARS-CoV-2 infection on male fertility. This is a single-center,
hospital-based observational study that included autopsied testicular and epididymal specimens of deceased COVID-19 male patients (n=6) and recruited recovering COVID-19 inpatients (n=23) with an equal number of age-matched controls, respectively. We performed
histopathological examinations on testicular and epididymal specimens, and also performed TUNEL assay and immunohistochemistry. Impairment of spermatogenesis was observed in COVID-19 patients, which could be partially explained as a result of an elevated immune
response in testis. Additionally, autoimmune orchitis occurred in some COVID-19 patients. |
|
|
Li, J, Chun, et al |
Zhonghua wei zhong bing ji jiu yi xue |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study explored the correlation between symptoms and their contribution to syndrome based on syndrome of lung damp-heat
accumulation in COVID-19 patients, thus to provide methodological basis for the syndrome diagnosis. There were 121 questionnaires referring to syndrome of lung damp-heat accumulation in total 654 questionnaires. The symptoms with frequency > 40% were fever
(53.72%), cough (47.93%), red tongue (45.45%), rapid pulse (43.80%), greasy fur (42.15%), yellow tongue (41.32%), fatigue (40.50%) and anorexia (40.50%). Association rule analysis showed that the symptom groups with strong binomial correlation included fever,
thirst, chest tightness, shortness of breath, cough, yellow phlegm, etc. The symptom groups with strong trinomial correlation included cough, yellow phlegm, phlegm sticky, anorexia, vomiting, heavy head and body, fever, thirst, fatigue, etc. The Bayesian
network model was established to obtain the probability distribution table of symptoms (groups), in which there was only one parent node (the upper node of each input variable) of fever, and the conditional probability was 0.54. The parent node of cough had
yellow phlegm and syndrome of lung damp-heat accumulation, indicating that there was a direct causal relationship between cough and yellow phlegm in syndrome of lung damp-heat accumulation, and the conditional probability of cough was 0.99 under the condition
of yellow phlegm. |
|
|
Li, J, Wang, et al |
J Gerontol B Psychol Sci Soc Sci |
Healthcare Response | Réponse des soins de santé |
The current study aims to explore person-centered communication between health care professionals and COVID-19 infected
older patients in acute care settings. It is challenging for healthcare professionals to provide care for COVID-19 infected older adults, especially for those with cognitive and sensory impairment, in acute care settings. Facilitating person-centered communication
is a significant strategy in responding to the pandemic crisis and a core element of person-centered care. |
|
|
Li, W, Chen, et al |
Proc Natl Acad Sci U S A |
Therapeutics| Thérapeutique Animal model | Modèle animal |
We identified panels of fully human monoclonal antibodies (mAbs) from large phage-displayed Fab, scFv, and VH libraries
by panning against the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) glycoprotein. A high-affinity Fab was selected from one of the libraries and converted to a full-size antibody, IgG1 ab1, which competed with human ACE2 for binding to RBD. It
potently neutralized replication-competent SARS-CoV-2 but not SARS-CoV, as measured by two different tissue culture assays, as well as a replication-competent mouse ACE2-adapted SARS-CoV-2 in BALB/c mice and native virus in hACE2-expressing transgenic mice
showing activity at the lowest tested dose of 2 mg/kg. Results suggest that IgG1 ab1 has potential for therapy and prophylaxis of SARS-CoV-2 infections. |
|
|
PMC7195441; Prognostic Value of Right Ventricular Longitudinal Strain in Patients
With COVID-19 |
Li, Y, Li, et al |
JACC Cardiovasc Imaging |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Investigated whether right ventricular longitudinal strain (RVLS) was independently predictive of higher mortality
in patients with coronavirus disease-2019 (COVID-19). One hundred twenty consecutive patients with COVID-19 who underwent echocardiographic examinations were enrolled in our study. Compared with patients in the highest RVLS tertile, those in the lowest tertile
were more likely to have higher heart rate; elevated levels of D-dimer and C-reactive protein; more high-flow oxygen and invasive mechanical ventilation therapy; higher incidence of acute heart injury, acute respiratory distress syndrome, and deep vein thrombosis;
and higher mortality. After a median follow-up period of 51 days, 18 patients died. Compared with survivors, nonsurvivors displayed enlarged right heart chambers, diminished RV function, and elevated pulmonary artery systolic pressure. Male sex, acute respiratory
distress syndrome, RVLS, RV fractional area change, and tricuspid annular plane systolic excursion were significant univariate predictors of higher risk for mortality. A Cox model using RVLS was found to predict higher mortality more accurately than a model
with RV fractional area change and tricuspid annular plane systolic excursion. |
|
Li, Y, Yang, et al |
Future microbiology |
Coronavirology| Coronavirologie |
Aim: The inference of coronavirus evolution is largely based on mutations in SARS-CoV-2 genome. Misinterpretation of
these mutations would mislead people about the evolution of SARS-CoV-2. Materials & methods: With 4521 lines of SARS-CoV-2, we obtained 3169 unique point mutation sites. We counted the numbers and calculated the minor allele frequency (MAF) of each mutation
type. Results: Nearly half of the point mutations are C-T mismatches and 20% are A-G mismatches. The MAF of C-T and A-G mismatches is significantly higher than MAF of other mutation types. Conclusion: The excessive C-T mismatches do not resemble the random
mutation profile. They are likely to be caused by the cytosine-to-uridine deamination system in hosts. |
|
|
Liang, Y, Chen, et al |
Eur Arch Psychiatry Clin Neurosci |
Mental Health |
|
We study the psychological status of medical staff after return to daily medical activities after local cases eradication
in Southern China. In total, we collected data from 51 nurses and 19 doctors, including 44 frontline medical workers and 26 control subjects. Similar to prior data, there is insignificant difference between the self-rating depression and anxiety scales of
younger and the older staff, as well as the COVID-19 contacting and non-contacting staff. |
|
|
Lin, HA, Lin, et al |
PLoS One |
Clinical data| Données cliniques |
This retrospective study was conducted at the Taipei Medical University Hospital, Taiwan. Patients who visited the
outdoor epidemic prevention screening station for respiratory infection from February 19 to April 30, 2020, were evaluated for blood biomarkers to distinguish COVID-19 from other respiratory infections. Monocyte distribution width (MDW) ≥ 20 and neutrophil-to-lymphocyte
ratio (NLR) effectively identified influenza infection. Thus, MDW and NLR can distinguish COVID-19 from influenza and URIs. |
|
|
Liu, C, Shi, et al |
Aging (Albany NY) |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In this study, we selected 74 clinical samples from 43 recovering inpatients for qPCR and Droplet Digital PCR (ddPCR)
synchronous blind detection, and established a cutoff value for ddPCR diagnosis of COVID-19. The results showed that at a cutoff value of 0.04 copies/μL, the ddPCR sensitivity and specificity are 97.6% and 100%, respectively. In addition, we also analyzed
18 retained samples from 9 discharged patients who relapsed. Although qPCR showed all 18 samples to be negative, ddPCR showed 12 to be positive, and there was only one patient with two negative samples; the other eight patients had at least one positive sample.
These results indicate that ddPCR could significantly improve the accuracy of COVID-19 diagnosis, especially for discharged patients with a low viral load, and help to reduce misdiagnosis during recovery. |
|
|
Characterization of Antibody Responses to SARS-CoV-2 in Convalescent
COVID-19 Patients |
Liu, C, Yu, et al |
J Med Virol |
Clinical data| Données cliniques Immunology | Immunologie |
This study aimed to determine the prevalence of anti-SARS-CoV-2 specific antibodies including IgG and IgM antibodies
and the dynamic changes in antibody levels in convalescent COVID-19 patients. A total of 159 blood samples were collected from 52 recovered COVID-19 patients up to six months after symptom onset for longitudinal serological tests. The positive rate of IgG
and IgM antibodies was 92.3% and 90.4% in the first month after symptom onset, and the seropositivity of IgG antibody remained high at all follow-up time points, whereas the seropositivity of IgM antibody decreased to 22.73% by the sixth months after symptom
onset. The level of IgG antibody was stable, the level of IgM antibody decreased slightly in the early convalescent phase and was detected in only five patients in the sixth month after symptom onset. The level of IgG antibody was higher in the severe and
critical group than in the moderate group. The anti-SARS-CoV-2 specific antibodies have a long-term persistence in convalescent COVID-19 patients, whether they have long-term protection need to be further investigated. |
|
Effect of control measure on the development of new
COVID-19 cases through SIR model simulation |
Liu, Fei, Lee, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
he trends in new corona virus cases in the US as well as New Jersey are simulated using a modified Susceptible-Infected-Recovered
(SIR) model. The new case graphs from the simulations reflect the new case trends in both the US and New Jersey and can be used to understand the mechanism behind the rates of corona virus infection as well as predict future corona virus trends. Comparisons
between the results of the simulations and observed data show the effectiveness of control measures such as quarantine, physical distancing, and wearing masks. The extended time period of control measures taken in New Jersey led to a gradual decline in new
cases reported daily while the US new cases showed a second wave of growth after control measures were implemented to a lesser extent. |
|
Liu, J, Liu, et al |
Jisuanji Fuzhu Sheji Yu Tuxingxue Xuebao/Journal of Computer-Aided Design and Computer Graphics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study proposed a COVID-19 epidemic visualization model based on data preprocessing and comprehensive analysis
of time axis interaction and SEIR model. Progressive epidemic analysis was used to visualize the epidemic situation of typical infectious diseases. Take Henan Province as an example, the epidemic situation of COVID-19 is revealed, the source characteristics
of COVID-19 are excavated, the epidemic pattern of COVID-19 is summarized, and the future trend of COVID-19 is predicted. |
|
|
I Don't Want to Go Back: Examining the Return to Physical Workspaces During COVID-19 |
Liu, Z, Van Egdom, et al |
J Occup Environ Med |
Mental Health |
|
We study US employee perspectives on return to physical workspaces. Women, non-Caucasians, and employees living in
multi-generational households were less willing to return. Blanket policies may miss the nuanced needs of different employee groups. Employers and policy makers should adopt flexible approaches. |
|
Lobato, FS, Libotte, et al |
Computational and mathematical methods in medicine |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this work, the SIDR (Susceptible, Infected, Dead, and Recovered) model is used to simulate the dynamic behavior
of COVID-19, and its parameters are estimated by formulating a robust inverse problem, that is, considering the sensitivity of design variables. For this purpose, a robust multiobjective optimization problem is formulated, considering the minimization of uncertainties
associated with the estimation process and the maximization of the robustness parameter. To solve this problem, the Multiobjective Stochastic Fractal Search algorithm is associated with the Effective Mean concept for the evaluation of robustness. The results
obtained considering real data of the epidemic in China demonstrate that the evaluation of the sensitivity of the design variables can provide more reliable results. |
|
|
COVID-19 detection in radiological text reports integrating entity recognition |
López-Úbeda, P, Díaz-Galiano, et al |
Computers in biology and medicine |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper we propose a text classification system to support clinicians with detecting COVID-19 related disorders
within radiological reports. Baseline results achieve 85% accuracy predicting lung involvement by COVID-19, which already offers competitive values that are difficult to overcome. |
|
Temporal patterns in the evolutionary genetic distance
of SARS-CoV-2 during the COVID-19 pandemic |
Lou, Jingzhi, Zhao, et al |
bioRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
In this study, we employed a computational approach to identify and trace the emerging patterns of the SARS-CoV-2 mutations,
and quantify accumulative genetic distance across different periods and proteins. Full-length human SARS-CoV-2 strains in United Kingdom were collected. Our results showed that the SARS-CoV-2 was in the process of continuous evolution, mainly involved in spike
protein (S protein), the RNA-dependent RNA polymerase (RdRp) region of open reading frame 1 (ORF1) and nucleocapsid protein (N protein). By contrast, mutations in other proteins were sporadic and genetic distance to the initial sequenced strain did not show
an increasing trend. |
|
Lowe, A, Pararajasingam, et al |
Clin Exp Dermatol |
Healthcare Response | Réponse des soins de santé |
A pre-pandemic UK-wide survey of dermatology registrars in training demonstrated a huge shortfall in trainee confidence
in their teledermatology skills, with only 15% feeling even slightly confident. Ninety-six % of trainees surveyed felt that more teaching in this area was needed. We carried out a follow-up trainee survey during the Covid-19 pandemic, which showed that the
sudden thrust into virtual working had achieved dramatic gains in trainee confidence, propelling the percentage of trainees that now felt slightly confident to 58%. But the shortfall remains, as does the pressing need to incorporate teledermatology into the
trainee teaching timetable. |
|
|
Lucchetti, G, Góes, et al |
Int J Soc Psychiatry |
Mental Health |
|
We valuate the use of religiosity and spirituality (R/S) during the COVID-19 pandemic in Brazil and to investigate
the association between R/S and the mental health consequences of social isolation. A total of 485 participants were included from all regions of Brazil. R/S seem to have an important role on the relief of suffering, having an influence on health outcomes
and minimizing the consequences of social isolation. These results highlight the importance of public health measures that ensure the continuity of R/S activities during the pandemic. |
|
|
Luo, JM, Lam, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
“Travel bubble”, a recent term initiated by travel operators, is a programme that allows tourists to travel to countries
nearby without quarantine requirements. This study investigates the relationship amongst fear of COVID-19, travel anxiety, risk attitude and travel intention towards “travel bubble” destinations. Results show that fear of COVID-19, travel anxiety and risk
attitude negatively impact travel intention. Furthermore, travel anxiety and risk attitude moderate the indirect impacts between fear of COVID-19 and travel intention. |
|
|
Development and validation of a new prognostic score system for COVID-19 |
Ma, K, Xia, et al |
Jpn J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to develop and validate a bedside risk analysis system for predicting the clinical severity and prognosis
of patients with COVID-19. The new scoring system comprised of eight variables, which included history of having malignant diseases, history of having diabetes mellitus, dyspnea, respiratory rate of >24 bpm, C-reactive protein (CRP) of >14 mg/L, white blood
cell count of >8×10(9)/L, platelets count of <180×10(12)/L, and lymphocyte count of <1×10(9)/L. The sensitivity analysis revealed that this new score performed better than the sequential organ failure assessment (SOFA) score at the first day of admission.
The receiver characteristic curve analysis revealed that this score predicted severe cases of COVID-19 infection at 0.831 and 0.798 of the area under the curve in the derivation and validation group. |
|
When Norms Collide: The Effect of Religious Holidays on Compliance
with COVID Guidelines |
Malhi, Fareena, Aftab, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
In the wake of the COVID-19 pandemic, this paper investigates the effect of a shift in social/religious norms on compliance
behaviour. Religion-based norms of behaviour have the potential to counteract newly established norms of health-preserving behaviours. One such event occurred during the Eid-ul-Fitr celebrations, which were particularly problematic for Muslim-majority populations.
We study the impact of such an event on compliance behaviour in one country – Pakistan – and find that, in a large sample of University students, compliance declines immediately after the religious holiday. Our effects are identified by unprompted delays in
fielding a survey measuring compliance with prescribed behaviours. We report a decline in compliance, with no observable decline in other well documented predictors of compliance behaviours (that is, risk perceptions, or trust in the authorities). We find
that this decline in compliance is largely attributable to male participants, with one important exception. We further confirm our results by conducting robustness checks incorporating matching techniques. |
|
Mamun, MA, Sakib, et al |
Journal of affective disorders |
Mental Health |
|
The present study examined the psychological consequences of COVID-19 in Bangladesh during the lockdown period. A nationwide
online cross-sectional survey study recruited 10,067 individuals covering all 64 districts in Bangladesh via social media (April 1-10, 2020). Common risk factors for suicidal ideation and depression included being young, being female, being a cigarette smoker,
having comorbid diseases, having high scores on the Fear COVID-19 Scale, and having insomnia symptoms. |
|
|
Mareev, VY, Orlova, et al |
Kardiologiya |
Therapeutics| Thérapeutique RCT |
Article in Russian. The article is devoted to the issue of effective treatment of the new coronavirus infection (COVID-19)
in the advanced stages of the disease. The results of the first randomized trials on the use of inhibitors of pro-inflammatory cytokines and chemokines - interleukin-6 (tocilizumab), interleukin-17 (secukinumab), Janus kinase blockers. The design of the original
COLORIT comparative study on the use of colchicine, ruxolitinib and secukinumab in the treatment of COVID-19 is presented. |
|
|
Blood transfusion activity in a general hospital during the COVID-19 pandemic |
Marín-Mori, K, González-Gascón, et al |
Vox Sang |
Healthcare Response | Réponse des soins de santé |
A retrospective study was conducted to evaluate blood transfusion practices from 15 March to 14 April 2020 at Hospital
Universitario Infanta Leonor (Madrid, Spain). During this month, with few exceptions, the hospital became a ‘COVID‐19’ centre. This is the first study to report a decrease in blood transfusions during the COVID‐19 pandemic in a general hospital and especially
in the intensive care unit. The results of this study suggest that COVID‐19 does not generally induce transfusion requiring anaemia. |
|
Masana, L, Correig, et al |
Eur Heart J Cardiovasc Pharmacother |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The aim of this retrospective observational study was to assess the effect of statin therapy at hospital admission
for COVID-19 on in-hospital mortality. A lower SARS-CoV-2 infection-related mortality was observed in patients treated with statin therapy prior to hospitalization. |
|
|
Benign SARS-CoV-2 infection in MOG-antibodies associated disorder during tocilizumab
treatment |
Masuccio, FG, Lo Re, et al |
Multiple Sclerosis and Related Disorders |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
In a subgroup of patients affected with novel Coronavirus disease (COVID-19), tocilizumab (an anti-IL-6 receptor) has
also increased the survival rate. We present the case of a 31-years-old Caucasian patient who experienced an almost asymptomatic Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) infection during treatment with tocilizumab, which was continued due
to the very high risk of relapses of the patient. According to this case, tocilizumab might be not discontinued during COVID-19. |
|
Mazzotta, C, Giancipoli, et al |
International Medical Case Reports Journal |
Clinical data| Données cliniques |
To article reports the clinical-epidemiological association between acute anterior uveitis and acute bilateral follicular
conjunctivitis in a 30-year-old female patient who had tested positive for the SARS-CoV-2 RT-PCR, in Italy. The report demonstrates that complicated acute anterior uveitis (iridocyclitis) with blurred vision could be associated with SARS-CoV-2 infection, being
potentially sight-threatening for early complicated lens opacity. |
|
|
Liquid chalk is an antiseptic against SARS-CoV-2 and
influenza A respiratory viruses |
McAuley, JulieL, Deerain, et al |
bioRxiv |
Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
We investigated whether liquid chalk is an antiseptic against highly pathogenic human viruses including, SARS-CoV-2,
influenza virus and noroviruses. The use and application of liquid chalk can be an effective and suitable antiseptic for major sporting events, such as the Olympic Games. |
|
McCoy, J, Cadegiani, et al |
J Eur Acad Dermatol Venereol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We hypothesized that 5-alpha-reductase inhibitors (5ARi) may reduce the severity of COVID-19 disease. To test this
hypothesis we conducted a retrospective cohort analysis on male subjects with laboratory confirmed SARS-CoV-2 infection in Brazil. For analysis, male subjects with androgenetic alopecia (AGA) were selected. A statistically significant reduction in the frequency
of 20 of the 29 clinical symptoms was observed in males with AGA using 5ARis compared to males with AGA not using 5ARis. The largest percent reductions were found in the frequency of anosmia (73%), ageusia (63%), headache (42%), and dry cough (56%). |
|
|
Mehrian, P, Farnia, et al |
Journal of Isfahan Medical School |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This paper discusses the role of computerized tomography scan in diagnosis and management of coronavirus disease 2019
(COVID-19). Computerized tomography scan (CT-scan) is widely available and low-cost and provides immediate results with high sensitivity. In some cases, CT-scan is capable of providing evidence for the disease before detection of viral RNA from upper respiratory
samples. CT-scan exhibits higher sensitivity, but lower specificity for diagnosis of COVID-19, compared to RT-PCR (sensitivity of 59-78% and 95-98% as well as specificity of approximately 100% and 96% for RT-PCR and chest CT-scan, respectively). Low sensitivity
for diagnosis of COVID-19 and ionizing radiation exposure are two major disadvantages of CT-scan, which can be resolved to a large extent by clinical and laboratory correlations and utilizing low-dose CT protocols. It seems that CT-scan can be ordered for
diagnosis of COVID-19 when PCR test is not feasible, or in case of high clinical suspicion in spite of negative PCR. |
|
|
Predictors of In-Hospital Mortality in Older Patients With COVID-19: The COVIDAge
Study |
Mendes, A, Serratrice, et al |
J Am Med Dir Assoc |
Epidemiology| Épidémiologie |
We aim to determine predictors of in-hospital mortality related to COVID-19 in older patients. In patients 65+ years
hospitalized for COVID-19, male sex, crackles, a higher fraction of inspired oxygen, and functionality were independent risk factors of mortality. These routine parameters, and not differences in age, should be used to evaluate prognosis in older patients. |
|
The Neat Dance of COVID-19: NEAT1, DANCR, and Co-Modulated Cholinergic RNAs Link
to Inflammation |
Meydan, C, Madrer, et al |
Frontiers in Immunology |
Clinical data| Données cliniques |
To seek the corresponding transcriptomic origins for the impact of COVID-19 infection and its aftermath consequences,
this study sought the relevance of long and short non-coding RNAs (ncRNAs) for susceptibility to COVID-19 infection. Selected inflammation-prone men and women of diverse ages among the cohort of Genome Tissue expression (GTEx) by mining RNA-seq datasets from
their lung, and blood tissues, followed by quantitative qRT-PCR, bioinformatics-based network analyses and thorough statistics compared to brain cell culture and infection tests with COVID-19 and H1N1 viruses. Discovered sharp declines of the lung pathology-associated
ncRNA DANCR and the nuclear paraspeckles forming neuroprotective ncRNA NEAT1. Accompanying increases in the acetylcholine-regulating transcripts capable of controlling inflammation co-appeared in SARS-CoV-2 infected but not H1N1 influenza infected lung cells. |
|
Critically ill patients with COVID-19 in Tokyo, Japan: A single-center case series |
Miike, S, Sakamoto, et al |
Journal of Infection and Chemotherapy |
Clinical data| Données cliniques |
This study aimed to describe the clinical courses and outcomes of critically ill patients with COVID-19 in Tokyo, Japan.
Between February 2, 2020, and June 30, 2020, 14 critically ill patients with COVID-19 were treated with MV. Most patients were male and had comorbidities, especially hypertension or diabetes; 35.7% were overweight and 21.4% were obese. The majority of the
patients had dyspnea on admission. The median duration of MV was 10.5 days, and the 28-day mortality rate was 35.7%. In the four patients with COVID-19 who died, the cause of death was respiratory failure. |
|
Self-reported cutaneous manifestations in 1,429 Brazilian COVID-19 patients |
Miot, HA, Ianhez, et al |
J Eur Acad Dermatol Venereol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to evaluate the prevalence of dermatologic manifestations reported by patients in Brazil with
COVID-19 using an electronic survey. Valid registers accounted for 43,444 participants: 39,693 healthy, 2,322 suspected/waiting confirmation, and 1,429 confirmed. Male sex, age older than 60, obesity, arterial hypertension, and diabetes were independently
associated with hospitalization. Thirty-one percent of participants with COVID-19 presented at least one dermatologic manifestation. Palmar erythema and scalp erythema were associated with hospitalization. |
|
Moreira, RodrigoA, Guzman, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here we discuss the protein structural stability based on the computational determination of the dynamic contact map
and the energetic difference of the spike protein conformations via the mapping of the hydration free energy by the Poisson-Boltzmann method. |
|
|
Morikawa, M, Shinoda, et al |
Intern Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to clarify clinical and laboratory characteristics of COVID-19 patients, and further explore the features
to detect COVID-19 pneumonia at the first visit to community-based hospitals. The clinical characteristics and results of blood tests were compared between the patients with and without pneumonia. Significant differences were seen in age, the frequency of
fever, tachycardia, desaturation (peripheral oxygen saturation ≤95%), any comorbidity, neutrocyte count and fraction, lymphocyte count and fraction, platelet count, lactate dehydrogenase, C-reactive protein (CRP), and fibrinogen between the patients with and
without pneumonia. Using a multivariable analysis, CRP ≥0.3 mg/dL and fibrinogen >400 mg/dL were found to be associated with the presence of pneumonia. |
|
|
COVID-19 Time Series Forecast Using Transmission Rate and
Meteorological Parameters as Features |
Mousavi, M, Salgotra, et al |
IEEE Computational Intelligence Magazine |
Modelling/ prediction| Modélisation/prédiction Transmission |
In this paper, a novel systematic platform for prediction of the future number of confirmed cases of COVID-19 is proposed,
based on several factors such as transmission rate, temperature, and humidity. The number of confirmed cases (CC) of COVID-19 in three states of India (Maharashtra, Tamil Nadu and Gujarat) is taken as a case study. It has been noted that stationary and nonstationary
parts of the features improved the prediction of the stationary and non-stationary trends of the number of confirmed cases, respectively. |
|
Longitudinal analysis of serology and neutralizing antibody levels in COVID19 convalescents |
Muecksch, F, Wise, et al |
J Infect Dis |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes Immunology | Immunologie |
We compare the ability of four high throughput automated serology assays to diagnose prior SARS-CoV-2 infection and
predict serum neutralizing activity. One widely used commercial platform that had an initial sensitivity of >95% declined to 71% at 81-100 days post diagnosis. The trajectories of median binding antibody titers measured over ~3 to 4 months were not dependent
on the use of SARS-CoV-2 N or S proteins as antigen. The median neutralization titer decreased by ~45% per month. Each serological assay gave quantitative antibody titers that correlated with SARS-CoV-2 neutralization titers, but S-based serological assay
measurements better predicted neutralization potency. |
|
PMC7577918; Survey data for COVID-19 vaccine preference analysis in the United Arab
Emirates |
Muqattash, R, Niankara, et al |
Data Brief |
Public Health response| Interventions de santé publique |
This article presents a novel data set on individuals' COVID-19 vaccine preferences in the United Arab Emirates (UAE).
The data set comprises (i) respondents socio-economic and demographic information, (ii) respondents willingness to spend time, and money to get the Covid-19 vaccine, and (iii) the vaccine determinants identified by the WHO's SAGE working group on immunization. |
|
Identification of a dominant CD8+ CTL epitope in the SARS-associated coronavirus
2 spike protein |
Muraoka, D, Situo, et al |
Vaccine |
Vaccine Research| Recherche sur les vaccins Immunology | Immunologie Animal model |
Modèle animal |
In this study, we have identified a CTL epitope in the SARS-CoV-2 spike (S) protein that could be used to measure the
cellular immune response against this protein. Potential predicted CTL epitopes of the SARS-CoV-2 S protein were investigated by immunizing BALB/c mice with a recombinant of the receptor-binding domain (RBD) of the S protein. Then, CD8+ T cells specific for
S-RBD were detected by stimulating with potential epitope peptides and then measuring the interferon-gamma production. Truncation of this peptide revealed that S-RBD-specific CD8+ T cells recognized a H2-Dd-restricted S526–533 peptide. In conclusion, this
animal model is suitable for evaluating the immunogenicity of SARS-CoV-2 vaccines. |
|
Ng, Oon Tek, Marimuthu, et al |
The Lancet Infectious Diseases |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
Investigated the proportion of asymptomatic carriers and transmission risk factors of SARS-CoV-2 among household and
non-household contacts. Between Jan 23 and April 3, 2020, 7770 close contacts (1863 household contacts, 2319 work contacts, and 3588 social contacts) linked to 1114 PCR-confirmed index cases were identified. Symptom-based PCR testing detected 188 COVID-19
cases, and 7582 close contacts completed quarantine without a positive SARS-CoV-2 PCR test. The secondary clinical attack rate was 5·9% for 1779 household contacts, 1·3% for 2231 work contacts, and 1·3% for 3508 social contacts. Bayesian analysis of serology
and symptom data obtained from 1150 close contacts (524 household contacts, 207 work contacts, and 419 social contacts) estimated that a symptom-based PCR-testing strategy missed 62% of COVID-19 diagnoses, and 36% of individuals with SARS-CoV-2 infection were
asymptomatic. |
|
|
Nguimkeu, P, Tadadjeu, et al |
World Dev |
Epidemiology| Épidémiologie |
Unlike initially predicted by WHO, the severity of the novel coronavirus pandemic has remained relatively low in Sub-Saharan
Africa. In this paper, we analyze the extent to which demographic and geographic factors associated to the disease explain this phenomenon. We found that proportion of population aged 65+, population density, and urbanization are significantly positively associated
with high numbers of active infected cases, while mean temperature around the first quarter (January-March) is negatively associated to this COVID-19 outcome. These factors are those for which Africa has a comparative advantage. In contrast, factors for which
Africa has a relative disadvantage, such as income and quality of health care infrastructure, are found to be insignificant predictors of the spread of the pandemic. |
|
|
Nguyen, TTP, Nguyen, et al |
Frontiers in Public Health |
Public Health response| Interventions de santé publique |
This study assessed perceptions and attitudes via the importance of national response measures to COVID-19 among people
under the nationwide partial lockdown of Vietnam. The proportion of participants strongly agreeing with the measure “Isolate people from abroad and people in contact with people infected with COVID 19” was the highest (96.9%), following by the measure “Obligatory
to wear face masks in public places” (96.8%), and “Blockade of places having new cases” (92.9%). Living in the Southern region, having a family with more than 5 people, and having post-graduate education were negatively correlated to the levels of perceived
importance of “Social distancing and community screening” measures. Meanwhile, having post-graduate education, working as white-collar workers , and having fixed-term, full-time employment were inversely associated with the levels of perceived importance of
the “Mandatory quarantine and personal protective equipment” measures. |
|
|
Noce, A, Santoro, et al |
Biol Direct |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study compared point of care test (POCT) lateral flow immunoassay (FIA) vs automated chemiluminescent immunoassay
(CLIA), in order to assess their specificity and sensibility for COVID-19 antibodies detection. The authors found different specificities and sensitivities for IgM and IgG tests. IgM POCT FIA method vs CLIA method (gold standard) has a low sensitivity (0.526),
while IgG POCT FIA method vs CLIA method (gold standard) test has a much higher sensitivity (0.937); further, with respect of IgG, FIA and CLIA could arguably provide equivalent information. FIA method could be helpful in assessing in short time, the possible
contagiousness of subjects that for work reasons cannot guarantee "social distancing". |
|
|
Noda, A, Morita, et al |
Intern Med |
Clinical data| Données cliniques |
In a COVID-19 ward, we used a novel wireless stethoscope with a telemedicine system and successfully recorded and shared
the lung sounds in real-time between the red and green zones. The fine crackles at the posterior right lower lung fields changed from mid-to-late (day 1) to late inspiratory crackles (day 3), which disappeared at day 5 along with an improvement in both the
clinical symptoms and thoracic CT findings. |
|
|
Predictors of CPAP outcome in hospitalized COVID-19 patients |
Noeman-Ahmed, Y, Gokaraju, et al |
Respirology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We conducted a retrospective cohort study to investigate the predictors of continuous positive airway pressure (CPAP)
outcome in COVID-19 patients admitted to our hospital in the UK. We report a 40% success of CPAP in COVID‐19 patients (n = 21/52). We identified five significant predictors for CPAP success: respiratory rate, PaO2 to FiO2 ratio, neutrophil to lymphocyte ratio,
SpO2 to FiO2 ratio pre‐CPAP and SpO2 to FiO2 ratio post‐CPAP. |
|
Nwajei, F, Anand, et al |
Journal of Stroke and Cerebrovascular Diseases |
Clinical data| Données cliniques |
Objective: To describe the presentation, barriers to diagnosis, treatment, and outcome of cerebral venous sinus thrombosis
(CVST) in patients with COVID-19. Methods: We abstracted data on all patients diagnosed with CVST and COVID-19 from March 1 to August 9, 2020 at Boston Medical Center. All 3 female patients were treated with intravenous hydration and anticoagulation. None
suffered hemorrhagic complications, and all were discharged home. |
|
|
Oany, AR, Mia, et al |
International journal of antimicrobial agents |
Therapeutics| Thérapeutique |
In this study, we have employed virtual screening approaches and selected 415 lead-like compounds from 103 million
chemical substances, based on the existing drugs, from PubChem databases as potential candidates for the S protein-mediated viral attachment inhibition. Thereafter, based on drug-likeness and Lipinski's rules, 44 lead-like compounds were docked within the
active side pocket of the viral-host attachment site of the S protein. Corresponding ligand properties and absorption, distribution, metabolism, excretion, and toxicity (ADMET) profile were measured. Furthermore, four novel inhibitors were designed and assessed
computationally for efficacy. The four designed novel lead compounds possessed more fascinating output without deviating from any of Lipinski's rules. They also showed higher bioavailability and the drug-likeness score was 0.56 and 1.81 compared with VE607
and SSAA09E2, respectively. All the screened compounds and novel compounds showed promising ADMET properties. |
|
|
Ochal, M, Romaszko, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
To assess variations in the consultation rate of patients in primary healthcare centers (PHCs) in consecutive months
of the pandemic. Data collected from two PHCs located in Olsztyn (Poland) were analyzed retrospectively. A large, statistically significant decrease in the consultation rate (consultation rate understood as the number of individuals seeking consultation in
relation to the number of people under care in a given time period) was revealed in each age group in the initial phase of the pandemic. The largest reduction in the consultation rate was revealed in the youngest age group, with the smallest occurring in the
oldest. In the group of patients older than 65 years of age, the consultation rate after 3 months of the pandemic was the same as before the outbreak. Variations in the consultation rate were independent of the epidemiological situation. |
|
|
O'Driscoll, M, Dos Santos, et al |
Nature |
Epidemiology| Épidémiologie |
Here we use age-specific COVID-19 death data from 45 countries and the results of 22 seroprevalence studies to investigate
the consistency of infection and fatality patterns across multiple countries. We find that the age distribution of deaths in younger age groups (<65 years) is very consistent across different settings and demonstrate how this data can provide robust estimates
of the share of the population that has been infected. We estimate that the infection-to-fatality ratio (IFR) is lowest among 5-9 years old, with a log-linear increase by age among individuals older than 30 years. Population age-structures and heterogeneous
burdens in nursing homes explain some but not all of the heterogeneity between countries in infection-fatality ratios. |
|
|
Okoshi, Tadashi, Sasaki, et al |
arXiv |
Mental Health |
|
The ability to estimate current affective statuses of web users has considerable potential towards the realization
of user-centric opportune services. However, determining the type of data to be used for such estimation as well as collecting the ground truth of such affective statuses are difficult in the real world situation. We propose a novel way of such estimation
based on a combinational use of user's web search queries and mobile sensor data. Our large-scale data analysis with about 11,000,000 users and 100 recent advertisement log revealed (1) the existence of certain class of advertisement to which mood-status-based
delivery would be significantly effective, (2) that our "National Mood Score" shows the ups and downs of people's moods in COVID-19 pandemic that inversely correlated to the number of patients, as well as the weekly mood rhythm of people. |
|
|
33081858; Environmental contamination in a COVID-19 intensive care unit (ICU) – What
is the risk? |
Ong, SWX, Lee, et al |
Infection Control and Hospital Epidemiology |
Epidemiology| Épidémiologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
We aimed to evaluate the extent of environmental contamination in the ICU and correlate this with patient and disease
factors, including the impact of different ventilatory modalities. Observational study where surface environmental samples collected from ICU patient rooms and common areas were tested by SARS-CoV-2 PCR, with select samples from the common area tested on cell
culture. 200 samples from 20 patient rooms, and 75 samples from common areas and the staff pantry, were tested. 14 rooms had at least one site contaminated, with an overall contamination rate of 14% (28 of 200 samples). Environmental contamination was not
associated with day of illness, ventilatory mode, aerosol generating procedures, or viral load. There was lower frequency of environmental contamination in ICU compared to GW rooms. Eight samples from the common area were positive, though all were negative
on cell culture. |
|
Onuora, C, Torti Obasi, et al |
International Sociology |
Public Health response| Interventions de santé publique |
Previous studies on the impact of Internet-powered media on health promotion have often neglected the relationship
between message recall and health behaviour. Such neglect makes it look as though exposure to media messages automatically leads to recall. Also, other studies appear to have paid less attention to understanding if the perception of the existence or otherwise
of a public health issue actually influences the effectiveness of health intervention. In the current study, the authors suggest a model that takes into consideration these existing gaps. They examined 470 social media users who were exposed to YouTube animated
cartoons on COVID-19 using an example from a developing country. The authors found, among others, that perception concerning the realness of COVID-19 was the greatest contributing factor in predicting the effectiveness of YouTube animated cartoons on health
behaviour. The scholarly theoretical and practical contributions of the findings are explored. © The Author(s) 2020. |
|
|
Integration of Machine Learning Models in PACS Systems to Support Diagnostic
in Radiology Services |
Osorno-Castillo, K, Fonnegra, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This paper presents a simple way of adding the use of machine learning models for the automatic analysis of medical
images in the radiological workflow using DICOM services provided by open source tools. An implementation case study is also presented, in which a deep learning architecture was trained for classifying chest X-ray images as normal, bacterial pneumonia or viral
pneumonia, including in the last case images of COVID-19 patients. |
|
Özçelik, N, Özyurt, et al |
J Med Virol |
Clinical data| Données cliniques |
This study aims to determine the clinical importance of platelet count and platelet indices in the differentiation
of COVID-19 from influenza and the value of these parameters in the differential diagnosis of COVID-19. According to laboratory findings, mean platelet volume (MPV) and MPV/platelet ratio were statistically significantly lower, whereas eosinophil count and
platelet distribution width level were significantly higher in the COVID-19 group. It was found that the most common symptom in both groups was dyspnea and that the symptom was more prevalent among the influenza patients. |
|
|
Padley, GJ, Desai, et al |
Seminars in thrombosis and hemostasis |
Clinical data| Données cliniques |
This editorial reports a case of a 40-year-old female with severe COVID-19 pneumonia who had catheter-directed thrombolysis
on veno-venous ECMO. |
|
|
Deep Learning Based Chest X-Ray Image as a Diagnostic Tool for COVID-19 |
Padma, T, Usha Kumari, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Scientific advancement of Artificial Intelligence in deploying a deep learning based medical field is remaining powerful
to handle a huge data with accurate and fast results in medical imaging to diagnose diseases more accurately and efficiently with further assistance in the remote areas. Proposed method is developed for analyzing chest X ray images to detect COVID-19 for binary
classes with an accuracy of 99% and validation accuracy of 98%, where the loss is approximately 0.15% by using convolution 2D techniques that are applied on the open source datasets of COVID-19 available at GitHub and Kaggle.. |
|
Panda, SK |
Results Phys |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study aims to discuss the prevalence of COVID-19 in U.S, Italy, Spain, France and China, where the virus spreads
most rapidly and causes tragic outcomes. Thereafter, we present new insights of existence and uniqueness solutions of the 2019-nCoV models via fractional and fractal-fractional operators by using fixed point methods. |
|
|
New-onset atrial fibrillation during COVID-19 infection
predicts poor prognosis |
Pardo Sanz, A, Salido Tahoces, et al |
Cardiol J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to analyze the cardiovascular outcomes of patients with new-onset atrial fibrillation (AF)
and COVID-19 infection. A group with new-onset AF (n = 12) was compared with a control group (total: n = 148, sinus rhythm: n = 118, previous AF: n = 30). New-onset AF patients were significantly older and hypertensive, as well as presenting more frequently
with a history of acute coronary syndrome and renal dysfunction. This group showed a higher incidence of thromboembolic events (41.7% vs. 4.1%; p < 0.001), bleeding (33.3% vs. 4.7%, p = 0.005), a combined endpoint of thrombosis and death (58.3 vs. 19.6%, p
= 0.006) and longer hospital stays (16.4 vs. 8.6 days, p < 0.001), with no differences in all-cause mortality. New-onset AF in COVID-19 patients presumably has a notable impact on prognosis. The appearance of new-onset AF is related to worse cardiovascular
outcomes, considering it as an independent predictor of embolic events. |
|
Perera, Rapm, Ko, et al |
J Clin Microbiol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We evaluate a recently developed surrogate virus neutralization test (sVNT) in comparison to 90% plaque reduction neutralization
tests (PRNT(90)) in human, canine, cat and hamster sera. With PRNT(90) as reference, sVNT had sensitivity of 98.9% and specificity of 98.8% respectively. Using a panel of immune sera to other coronaviruses, we confirm the lack of cross reactivity to other
coronaviruses in SARS-CoV-2 sVNT and PRNT(90) assays, except for cross-reactivity to SARS-CoV-1 in sVNT. |
|
|
Pinna, C, Cotella, et al |
Revista de la Federacion Argentina de Cardiologia |
Healthcare Response | Réponse des soins de santé |
This study evaluated the impact of the change in the number of medical consultations by rotation and the number of
hospitalizations in a cardiology center from January 1, 2020 to April 20, 2020 . There were 1532 medical consultations and 290 hospitalizations evaluated. A drop of 55.8% in the number of medical consultations during the QP (37% due to dyspnea, 45% due to
chest pain, 72% due to hypertension) was observed. There was a 47.2% drop in the number of hospitalizations in the QP (55.6% decompensated heart failure, 44.9% NSTEMI, 26.9% STEMI). The recent pandemic caused by COVID-19 is associated with a significant drop
in the rate of consultations by the emergency service and in the number of hospitalizations in the coronary unit. |
|
|
Pitsillou, E, Liang, et al |
Computational Biology and Chemistry |
Therapeutics| Thérapeutique |
Our aim was to identify lead compounds with potential inhibitory effects on SARS-CoV-2 main protease . Our findings,
and those highlighted by others indicate that hypericin and cyanidin-3-O-glucoside formed stable interactions with the Mpro active site and are suitable candidates for progress to in vitro and in vivo antiviral studies. |
|
|
Modeling partial lockdowns in multiplex networks using partition strategies |
Plazas, Adria, Malvestio, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this work, we propose a network approach to model the implementation of a partial lockdown, breaking the society
into disconnected components, or partitions. Our model is composed by two main ingredients: a multiplex network representing human contacts within different contexts, formed by a Household layer, a Work layer, and a third Social layer including generic social
interactions, and a Susceptible-Infected-Recovered process that mimics the epidemic spreading. We compare different partition strategies, with a twofold aim: reducing the epidemic outbreak and minimizing the economic cost associated to the partial lockdown.
We also show that the inclusion of unconstrained social interactions dramatically increases the epidemic spreading, while different kinds of restrictions on social interactions help in keeping the benefices of the network partition. |
|
Pourabdollah Toutkaboni, M, Askari, et al |
New Microbes New Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to determine the characteristics of COVID-2019 among the Iranian population. Totally, 129/1061 (12.2%) patients
died during hospitalization in the ward or intensive care unit. From the remaining 932 individuals, 46 (5.0%) were admitted to the intensive care unit and 886 (95.0%) were hospitalized in the ward. Those patients who died were significantly older than those
hospitalized in the ward. 708 (66.7%) patients had lymphopenia. Among the laboratory tests, D-dimer, serum ferritin and albumin had the strongest correlations with mortality. |
|
|
Qasim, A, Mansour, et al |
Intractable Rare Dis Res |
Clinical data| Données cliniques |
This was a case report of a patient that was immunosuppressed by AIDS disease and chemotherapy for cancer who contracted
SARS-CoV-2 infection and had a mild disease. The authors also conducted a literature review to identify characteristics and outcomes of people living with HIV and COVID-19. The findings from the case reports and case series indicate that the risk of death
or severe disease from COVID-19 in HIV positive patients was lower than observed in the general population, which may indicate a possible protective effect of uncontrolled HIV in preventing the complications associated with the massive inflammatory response. |
|
|
Impact of the COVID-19 Pandemic on Quality of Life and Mental
Health in Children and Adolescents |
Ravens-Sieberer, Ulrike |
SSRN- Lancet prepublication |
Mental Health |
|
The current study is the first nationwide representative study to investigate the impact of the COVID-19 pandemic on
health-related quality of life (HRQoL) and mental health of children and adolescents in Germany from the perspective of children themselves. |
|
Ravindranath, Sunil, Venkatesh, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
A cross-sectional study was conducted to reflect the appropriateness and adherence of SARI definition in two tertiary
care medical college hospitals in triaging COVID 19 suspect cases and assessed the challenges in admission, diagnosis and treatment of non COVID 19 diseases. The adherence to SARI definition while triaging COVID suspect cases to intensive care units was low
among the clinicians. There were hindrances in the diagnosis and treatment of non COVID diseases due to COVID suspect status of the patient. However, treatment outcomes of these patients were comparable to critically ill population with similar disease severity
scores suggesting that quality of care may not have been compromised despite the pandemic. |
|
|
Reforma, LG, Duffy, et al |
Am J Obstet Gynecol MFM |
Healthcare Response | Réponse des soins de santé |
This study aimed to describe the feasibility and clinical and process outcomes associated with a multidisciplinary
telemedicine surveillance model to triage and manage obstetrical patients with known exposures and symptoms of COVID-19. A multidisciplinary telemedicine surveillance model with obstetrical physicians and nurses to standardize ambulatory care for obstetrical
patients with confirmed or suspected COVID-19 based on the symptoms or exposures at an urban academic tertiary care center with multiple hospital-affiliated and community-based practices was implemented. A total of 135 patients were enrolled in the multidisciplinary
telemedicine model from March 17 to April 19, 2020, of whom 130 were pregnant and 5 were recently postpartum. Patients were enrolled in the telemedicine model for a median of 7 days (interquartile range, 4-8) and averaged 1 phone call daily, resulting in
891 nursing calls and 20 physician calls over 1 month. A multidisciplinary telemedicine surveillance model for outpatient management of obstetrical patients with COVID-19 symptoms and exposures is feasible and resulted in rates of ambulatory management similar
to those seen in nonpregnant patients. |
|
|
Rgeeb, A, Al-Mudhafer, et al |
European Journal of Molecular and Clinical Medicine |
Clinical data| Données cliniques |
Case report of a 60 year-old male from Najaf, who went to the emergency department with a 3-day history of drowsiness
and anorexia after COVID-19-related fever and myalgias. Article describes the neurological manifestations, treatment and outcome of this patient. |
|
|
Ribeiro, M, Nisi, et al |
|
Public Health response| Interventions de santé publique |
In this paper, we present a real-world study where a community-based tracking infrastructure has been put to good use
for understanding human mobility during the COVID-19 outbreak, in order to contrast its diffusion. In particular, the infrastructure, deployed in 81 points of interests (POIs) across the Madeira Islands (Portugal), can collect a massive amount of spatio-temporal
data, that can be enriched with potentially independent data sources of additional values (such as the official number of people affected by the coronavirus disease), and crowdsourced data collected by citizens. These enriched hyper-local data can be manipulated
to provide i) stakeholders with a visual tool to contrast COVID-19 diffusion through human mobility monitoring, and ii) citizens with an interactive tool to visualize, in real-time, how crowded is a POI and plan their daily activities, and contribute to the
data acquisition. Here we present the deployed community-based infrastructure and the data visualization interactive web application, designed to extract meaningful information from human mobility data during the COVID-19 outbreak. |
|
|
Richardson, C, Patton, et al |
General hospital psychiatry |
Mental Health |
|
To describe the impact of the COVID-19 pandemic on help-seeking behaviors among individuals with eating disorders and
caregivers. We analyzed service utilization data from the National Eating Disorder Information Centre (NEDIC). We compared the number of contacts and symptom frequency between the pandemic period and previous years. NEDIC was contacted 609 times during March
1–April 30, 2020 (72.1% individuals affected by disordered eating, 20.4% caregivers). The number of total contacts significantly increased from 2018 to 2019 and 2018 to 2020 (X2(3) = 50.34, p <.001). Among affected individuals (80.4% women), the number of
contacts during the pandemic period was significantly higher (n = 439; X2(2) = 92.74, p <.001) compared to 2018 (n = 197) and 2019 (n = 312). Thematic analysis of instant chats from the pandemic year revealed four emerging themes: 1) lack of access to treatment,
2) worsening of symptoms, 3) feeling out of control, and 4) need for support. |
|
|
Roda, A, Cavalera, et al |
Biosensors and Bioelectronics |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes Immunology | Immunologie |
This IgA lateral flow immunosensor could be useful for noninvasively monitoring early immune responses to COVID-19
and for investigating the diagnostic/prognostic utility of salivary IgA in the context of large-scale screening to assess the efficacy of SARS-CoV-2 vaccines. |
|
|
32979342; Compartmental immunophenotyping in COVID-19 ARDS: A case series |
Ronit, A, Berg, et al |
Journal of Allergy and Clinical Immunology |
Clinical data| Données cliniques Immunology | Immunologie |
Our aim was to phenotype leukocyte subpopulations and the cytokine milieu in the lungs and blood of critically ill
patients with COVID-19 acute respiratory distress syndrome (ARDS). We consecutively included patients less than 72 hours after intubation. Bronchoalveolar lavage fluid was evaluated by microscopy; bronchoalveolar lavage fluid and blood were assessed by 10-color
flow cytometry and a multiplex cytokine panel. Four mechanically ventilated patients (aged 40-75 years) with moderate-to-severe COVID-19 ARDS were included. Findings demonstrate that COVID-19 ARDS exhibits a distinct immunologic profile in the lungs, with
a depleted and exhausted CD4 and CD8 T-cell population that resides within a heavily hyperinflammatory milieu. |
|
Rothe, K, Feihl, et al |
Eur J Clin Microbiol Infect Dis |
Clinical data| Données cliniques |
We performed a retrospective study of clinical and microbiological characteristics of 140 COVID-19 patients admitted
between February and April 2020 to a German University hospital, with a focus on bacterial co-infections and antimicrobial therapy. According to the implemented local antibiotic stewardship guidelines, the most commonly used antibiotic regimen was ampicillin/sulbactam
(41.5%) with a median duration of 6 (range 1-13) days. In critically ill patients admitted to intensive care units (n = 50), co-infections with Enterobacterales (34.0%) and Aspergillus fumigatus (18.0%) were detected. |
|
|
33090428; Short report - COVID-19 and weather parameters: Pune, India |
Roy, MP |
European review for medical and pharmacological sciences |
Epidemiology| Épidémiologie |
Weather parameters may have some role in determining the spread of Coronavirus disease 2019. Daily data on COVID-19
from Pune, India were collected from 17th May to 4th July 2020 and analyzed with such parameters. Relative humidity was found to have a positive relationship with the number of daily cases, even after taking a lag period of one week. Further studies may be
helpful in understanding such relationships. |
|
Chilblain-like lesions with prominent bullae in a patient with COVID-19 |
Rubin, A, Alamgir, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
A 27-year-old patient presented with acral chilblain-like lesions atypical of dermatological presentations appearing
in current reports of COVID-19. Prominent bullae had formed on the dorsa of her toes and became haemorrhagic 2 days after the initial presentation. The patient reported 10 days of ageusia and anosmia 6 weeks prior to the manifestation of her toe lesions, with
no other symptoms. A nasopharyngeal swab test for SARS-CoV-2 RNA was positive. |
|
Rubio-San-Simón, A, André, et al |
European journal of cancer |
Healthcare Response | Réponse des soins de santé |
We analysed the impact of the COVID-19 pandemic on the conduct of paediatric cancer phase I–II trials in Europe through
the experience of the Innovative Therapies for Children with Cancer (ITCC). A survey was sent to all ITCC-accredited early-phase clinical trial hospitals including questions about impact on staff activities, recruitment, patient care, supply of investigational
products and legal aspects, between 1st March and 30th April 2020. Thirty-one of 53 hospitals from 12 countries participated. Challenges reported included staff constraints (30% drop), reduction in planned monitoring activity (67% drop of site initiation visits
and 64% of monitoring visits) and patient recruitment (61% drop compared with that in 2019). The percentage of phase I, phase II trials and molecular platforms closing to recruitment in at least one site was 48.5%, 61.3% and 64.3%, respectively. In addition,
26% of sites had restrictions on performing trial assessments because of local contingency plans. Almost half of the units suffered impact upon pending contracts. Most hospitals (65%) are planning on improving organisational and structural changes. The study
reveals a profound disruption of paediatric cancer early-phase clinical research due to the COVID-19 pandemic across Europe. Reported difficulties affected both patient care and monitoring activity. Efforts should be made to reallocate resources to avoid lost
opportunities for patients and to allow the continued advancement of oncology research. |
|
|
Rui, R, Tian, et al |
Biom J |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this research, we estimate the case fatality rate (CFR) of COVID‐19 and quantify the effect of quarantine strategy
utilized in Wuhan by developing an extended Susceptible–Infected–Recovered (SIR) model. The outcomes suggest that the CFR is 4.4% (95% CI [3.6%, 5.2%]) and the effect of the quarantine strategy is 99.3% (95% CI [99.2%, 99.5%]), which implies that such a method
can significantly reduce the number of infections. |
|
|
Russo, V, Carbone, et al |
Frontiers in Pharmacology |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study describes the incidence of extreme QTc interval prolongation among COVID-19 patients on this triple combination
with Lopinavir/Ritonavir (LPN/RTN), hydroxychloroquine (HQ) and azithromycin (AZT) experimental treatment and identifies the clinical features associated with extreme QTc prolongation. Hypertension (66.7%) and diabetes (25.3%) were the most prevalent cardiovascular
comorbidities. Twenty patients (23%) showed extreme QTc interval prolongation; no clinical, electrocardiographic or pharmacological characteristics have been associated to extreme QTc prolongation, except the history of ischemic stroke (P= 0,007). One torsade
de pointes (TdP) in patient with QTc extreme prolongation (QTc: 560 ms) after 5 days of therapy was recorded. Observed a high incidence of extreme QTc interval prolongation among COVID-19 patients on triple combination therapy. |
|
|
Saadeh, D, Sacre, et al |
Perspect Psychiatr Care |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to assess the knowledge, attitudes, and practices toward COVID-19 among nurses in Lebanon.
The majority had sufficient knowledge of COVID-19; 62% declared being afraid of getting infected whereas 90% were afraid for their family members to get infected due to their occupational exposure. The majority of nurses (84.6%) declared following infection
prevention and control precautions. |
|
|
Sakowicz, A, Ayala, et al |
Am J Obstet Gynecol MFM |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective cohort study aimed to compare sociodemographic and clinical characteristics of pregnant women with
and without SARS-CoV-2 infection and, among those with SARS-CoV-2, to compare characteristics of those who reported coronavirus disease symptoms and those who were asymptomatic at diagnosis. 101/1418 (7.1%) of women were positive. 77 (76.2%) were symptomatic
at the time of diagnosis. Compared with women who had a negative test result, those with a positive test result were younger and were more likely to have public insurance, to identify as black or African American or Latina, to be unmarried, to be obese, to
have preexisting pulmonary disease, and to have living children. There were no significant differences identified between women who were symptomatic and asymptomatic. |
|
|
Working conditions and health in Spain during the COVID-19 pandemic: Minding the
gap |
Salas-Nicás, S, Moncada, et al |
Safety Science |
Mental Health |
|
The objective of this study is to describe the impact of COVID-19 on the working conditions and health of wage-earners
in Spain .Cross-sectional study carried out between the end of April and the end of May 2020 through an online survey. COVID-19 increased high exposures to harmful working conditions and very poor health indicators with important inequalities are observed
according to class, gender, age and wage. |
|
Salvia, A, Morone, et al |
Frontiers in Neurology |
Healthcare Response | Réponse des soins de santé |
This observational study reports on the data from a large sample of inpatients, clinical staff and other workers at
an Italian neurorehabilitation hospital dealing with SARS-CoV-2 infections, in order to analyze how it might have affected the management and the effectiveness of neurorehabilitation. Four patients and three clinical professionals were positive for COVID-19
infection. Six out of these seven people were from the same ward. Several measures were taken to handle the infection, putting in place many restrictions, with a significant reduction in new admissions to the hospital (p < 0.001). However, neither the amount
of neurorehabilitation for inpatients (p = 0.681) nor the effectiveness of treatments (p = 0.464) were reduced when compared to the data from 2019. |
|
|
Saraswathi, I, Saikarthik, et al |
PeerJ |
Mental Health |
|
A prospective longitudinal study was conducted on 217 undergraduate medical students to assess depression, anxiety,
and stress levels due to pandemic. The average scores of depression, anxiety, and stress during the baseline survey were 7.55 ± 7.86, 4.6 ± 6.19 and 7.31 ± 7.34 with the prevalence (95% Cl) of 33.2% 27-39.9%], 21.2% 16-27.2%] and 20.7% 15.5-26.7%]; in follow-up
survey, the mean scores were 8.16 ± 8.9, 6.11 ± 7.13 and 9.31 ± 8.18 with the prevalence being 35.5% 29.1-42.2%], 33.2% 27-39.9%] and 24.9% 19.3-31.2%] for depression, anxiety, and stress respectively. There was a significant increase in both the prevalence
and levels of anxiety and stress (P < 0.001), with depression remaining unchanged during COVID-19, irrespective of gender, year of study, place of residence and family's monthly income. Poor sleep quality, higher levels of baseline depression, anxiety, and
stress, higher COVID-19-GA, COVID-19 patients in family/friends and direct interactions with COVID-19 patients were found to be significant predictors of negative mental health in undergraduate medical students. |
|
|
SB, O'N, Byrne, et al |
Can Assoc Radiol J |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We aim to compare diagnostic performance and inter-/intra-observer among chest radiologists in the interpretation of
RSNA and CO-RADS reporting systems and assess clinician preference. Chest CT scans of 279 patients with suspected COVID-19 who underwent RT-PCR testing were retrospectively and independently examined. RSNA and CO-RADS reporting systems are consistent and
reproducible with near perfect inter-/intra-observer agreement and excellent positive predictive value. End-users preferred the reporting language in the RSNA system. |
|
|
Rapid SARS-CoV-2 testing in primary material based on a novel multiplex RT-LAMP
assay |
Schermer, B, Fabretti, et al |
PLoS One |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We tested PCR-independent methods for the detection of SARS-CoV-2 RNA from primary material (nasopharyngeal swabs)
including reverse transcription loop-mediated isothermal amplification (RT-LAMP) and specific high-sensitivity enzymatic reporter unlocking (SHERLOCK). Whilst specificity of standard RT-LAMP assays appears to be satisfactory, sensitivity does not reach the
current gold-standard quantitative real-time polymerase chain reaction (qPCR) assays yet. We describe a novel multiplexed RT-LAMP approach and validate its sensitivity on primary samples. This approach allows for fast and reliable identification of infected
individuals. Primer optimization and multiplexing helps to increase sensitivity significantly. In addition, we directly compare and combine our novel RT-LAMP assays with SHERLOCK. |
|
They're Dying in the Suburbs: COVID-19 Cases and
Deaths by Geography in Louisiana (USA) |
Schnake-Mahl, Alina, Bilal, et al |
medRxiv |
Epidemiology| Épidémiologie |
In this study, we compare geographic and temporal trends in COVID-19 cases and deaths in Louisiana, one of the few
states with high rates of COVID-19 during both the spring and summer. We find that incidence and mortality rates were initially highest in New Orleans. By the second peak, trends reversed: suburban areas experienced higher rates than New Orleans and similar
rates to other urban and rural areas. We also find that increased social vulnerability was associated with increased positivity and incidence during the first peak. During the second peak, these associations reversed in New Orleans while persisting in other
urban, suburban, and rural areas. |
|
Schöler, L, Le-Trilling, et al |
Frontiers in Immunology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This research established a simple, rapid, and automated SARS-CoV-2 neutralization assay employing an in-cell ELISA
(icELISA) approach. Applying increased infectious doses, the icELISA-based neutralization test (icNT) was superior to PRNT in discriminating convalescent sera with high from those with intermediate neutralizing capacities. In addition, the icNT was found
to be specific, discriminating between SARS-CoV-2-specific NAbs and those raised against other coronaviruses. Altogether, the SARS-CoV-2 icELISA test allows rapid (<48 h in total, read-out in seconds) and automated quantification of virus infection in cell
culture to evaluate the efficacy of NAbs and antiviral drugs using reagents and equipment present in most routine diagnostics departments. |
|
|
Sciandra, A |
|
Public Health response| Interventions de santé publique |
This paper analyzed the Italian social media communication about COVID-19 through a Twitter dataset collected in two
months. The analysis of the conversations going on Twitter, through the odds ratios and the similarities of word embeddings, managed to capture events, topics, and personalities of the COVID-19 emergency. Descriptive analysis suggested that the information
provided by the data may reveal the terms used differently in various time periods, thereby capturing changes in online discussions as a result of government measures that have a major impact on people's lives. The sentiment analysis showed a certain discordance
and the need for a reliable classification through human tagging, in order to provide an acceptable estimate of the polarity of the texts. Finally, word embeddings techniques showed at a descriptive level the ability to capture semantic and context similarities,
while predictive models based on word embeddings failed to significantly improve the accuracy of the classification of some variables. |
|
|
Optimal minimal-contact customer routing through grocery stores |
Sen, Diptangshu, Ramamohan, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
Present an optimization framework for identifying routes through a grocery store that eliminate or minimize contacts
between customers at grocery stock points while also minimizing the time spent within the store. We develop a discrete-event simulation of the customer arrival process, and simulate the arrival of customers with varying shopping list sizes and movement patterns.
We then present two optimization formulations for generating optimal shopping routes on a real-time basis for each customer arriving to the store given the route information of other customers already present in the store. The first formulation eliminates
contacts between customers whereas the second minimizes contacts between customers. We also explore an alternate scenario for the deployment of these formulations wherein the customers and the store can plan visits ahead of time. |
|
SARS-CoV2 infection in a multiple sclerosis patient treated with natalizumab - A case
presentation |
Șerban, G, Bălașa, et al |
Acta Marisiensis - Seria Medica |
Clinical data| Données cliniques |
Authors describe the first case from Romania of a MS patient treated with Natalizumab who subsequently acquired SARS-CoV2
infection and whose recovery was excellent, with no functional neurological or respiratory sequelae. The favourable evolution of our patient supports the potential therapeutic effect Natalizumab might have in SARS-CoV2 treatment by specifically blocking integrins
and by its immunosuppressant characteristics. |
|
Dynamics models for identifying the key transmission parameters of the COVID-19
disease |
Shahzad, M, Abdel-Aty, et al |
Alexandria Engineering Journal |
Modelling/ prediction| Modélisation/prédiction Transmission |
In this paper, we develop the models for coronavirus disease at different stages with the addition of more parameters
due to interactions among the individuals. Then, some key computational simulations and sensitivity analysis are investigated. Further, the local sensitivities for each model state concerning the model parameters are computed using the model reduction techniques:
the dynamical models are eventually changed with the change of parameters are represented graphically. We suggest two simple models of the COVID-19 to incorporate the impact of social awareness programs conducted by public health officials with quarantine
strategies in hospitals. |
|
Shan, H, Lyu, et al |
Zhonghua wei zhong bing ji jiu yi xue |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The aim of this study was to investigate the relationship between the changes of inflammatory cytokine levels and prognosis
of patients with critical coronavirus disease 2019 (COVID-19) undergoing invasive mechanical ventilation (IMV). The levels of inflammatory cytokine including IL-6, IL-10, and TNF-α increased significantly with aggravation in critical COVID-19 patients undergoing
IMV, especially IL-6. IL-6 was an independent risk factor for death of critical COVID-19 patients undergoing IMV. |
|
|
Shao, Z, Feng, et al |
Clinical and Translational Immunology |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
325 patients with laboratory-confirmed critical COVID-19 were enrolled from 4 government-designated COVID-19 treatment
centres in southern China from December 2019 to March 2020. In the enrolled 325 patients, 174 cases used IVIG and 151 cases did not. The 28-day mortality was improved with IVIG after adjusting confounding in overall cohort (P = 0.0014), and the in-hospital
and the total duration of disease were longer in the IVIG group (P 15 g per day) exhibited significant reduction in 60-day mortality in the critical-type patients. Early administration of IVIG with high dose improves the prognosis of critical-type patients
with COVID-19. |
|
|
Epidemiological Features of 105 Patients Infected with the COVID-19 |
Shi, JC, Yu, et al |
Journal of the National Medical Association |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to investigate and evaluate the clinical features of patients infected with COVID-19 outside of Wuhan.
105 patients (57 male and 48 female) were confirmed to have COVID-19 infection. Among the 105 patients, 55 (52%) had made short trips to Wuhan during the two weeks before the onset of illness, and these were the first-generation confirmed cases. An exact date
of close contact with someone in Wenzhou with confirmed or suspected COVID-19 infection from Wuhan (the second-generation confirmed cases) could be provided by 38 (36%) patients. Of the remaining patients, six (6%; the third-generation confirmed cases) were
familial clusters of the second-generation confirmed cases, three (3%) had no definite epidemiological features, and 16 (15%) were from the same location as for the case report. |
|
A Call for Antimicrobial Stewardship in Patients
with COVID-19: A Nationwide Cohort Study in Korea |
Shin, DH, Kang, et al |
Clin Microbiol Infect |
Therapeutics| Thérapeutique Healthcare Response | Réponse des soins de santé |
We retrospectively reviewed data on all adults (age ≥19 years) with confirmed COVID-19 admitted to hospitals or living
treatment centres between January 1 and May 15, 2020. Of 6,871 patients hospitalized with COVID-19 in Korea, 35.21% were prescribed antibiotics, and 22.16% received antibiotics against either methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa.
There is an urgent need for antimicrobial stewardship for COVID-19 to prevent the collateral damage associated with antibiotic overuse. |
|
Shinkariov, S, Zingerman, et al |
|
Healthcare Response | Réponse des soins de santé |
The System collects, organizes and saves personal medical information according with personal electronic medical case
history structure. The system had been tested in 22 medical organizations in Russia. Ways of further perspective research and development of the system are discussed. |
|
|
Modeling the impact of delaying surgery for early esophageal cancer in the era
of COVID-19 |
Shipe, ME, Baechle, et al |
Surg Endosc |
Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins
de santé |
We sought to model immediate versus delayed surgical resection in a T1b esophageal adenocarcinoma. A decision analysis
model was developed, and sensitivity analyses performed. The base case was a 65-year-old male smoker presenting with cT1b esophageal adenocarcinoma scheduled for esophagectomy during the COVID-19 pandemic. Immediate resection of early esophageal cancer during
the COVID-19 pandemic did not decrease 5-year survival when compared to resection after 3 months for the base case scenario. However, as the risk of perioperative COVID-19 infection increases above 7%, a delayed approach has improved 5-year survival. |
|
Covid-19 effects on the workload of Iranian
healthcare workers |
Shoja, E, Aghamohammadi, et al |
BMC Public Health |
Mental Health |
|
In this study, we aimed to evaluate the impact of the COVID-19 epidemic on the workload and mental health of Iranian
medical staff. Health workers who encountered COVID- 19 patients, were subjected to more task load compared to those who had no contact with COVID- 19 patients at the workplace (p < 0.001). In terms of the subscale score of NASA-TLX, nurses had more scores
in mental pressure, physical pressure, time pressure (temporal), and frustration compared to the other jobs (p < 0.05). Moreover, nurses had significantly more workload compared to the other jobs. |
|
A Covid-19 Patient with Complement-Mediated Coagulopathy and Severe Thrombosis |
Showers, CR, Nuovo, et al |
Pathobiology |
Clinical data| Données cliniques |
We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for
antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced and complement-mediated vascular injury and thrombosis, consistent with prior reports. Serial aPL testing demonstrated high levels of anticardiolipin antibodies
(aCL) that declined to insignificant levels over a period of 5 weeks. We hypothesize that SARS-CoV-2 viral-induced aPL contributed to severe Covid-19-associated coagulopathy in this patient. |
|
Singh, Asmit Kumar, Mehan, et al |
arXiv |
Public Health response| Interventions de santé publique |
COVID-19 has affected the entire world. One useful protection method for people against COVID-19 is to wear masks in
public areas. Across the globe, many public service providers have mandated correctly wearing masks to use their services. This paper proposes two new datasets VAriety MAsks - Classification VAMA-C) and VAriety MAsks - Segmentation (VAMA-S), for mask detection
and mask fit analysis tasks, respectively. We propose a framework for classifying masked and unmasked faces and a segmentation based model to calculate the mask-fit score. Both the models trained in this study achieved an accuracy of 98%. Using the two trained
deep learning models, 2.04 million social media images for six major US cities were analyzed. By comparing the regulations, an increase in masks worn in images as the COVID-19 cases rose in these cities was observed, particularly when their respective states
imposed strict regulations. Furthermore, mask compliance in the Black Lives Matter protest was analyzed, eliciting that 40% of the people in group photos wore masks, and 45% of them wore the masks with a fit score of greater than 80%. |
|
|
Pulmonary Thromboembolism
in a Patient with COVID-19 after Breast Reconstruction |
Siotos, C, Doscher, et al |
Plast Reconstr Surg |
Clinical data| Données cliniques |
We present a case of a breast reconstruction patient with reactivated coronavirus disease 2019 (COVID-19) infection
and postoperative pulmonary thromboembolism. |
|
Soares, CD, Mosqueda-Taylor, et al |
Br J Dermatol |
Clinical data| Données cliniques |
A 23‐year‐old woman presented with vesiculobullous lesions in the lips with an erythematous halo (a, b). She also presented
with fever and dry cough starting 3 days before. Polymerase chain reaction for SARS‐CoV‐2 was positive. Immunohistochemistry for the SARS‐CoV‐2 spike protein was positive in inflammatory endothelial cells and keratinocytes, and acinar and ductal cells of the
minor salivary glands. To our knowledge, this is the first report showing the SARS‐CoV‐2 spike protein in oral lesions of patients with COVID‐19. |
|
|
Soliman, May Sherif, AbdelFattah, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
The novel severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is causing an unprecedented pandemic, threatening
global health, lifestyle, and economy. Genomic surveillance continues to be a critical effort towards tracking and containing the virus. We here report the successful assembly of one single gapless, unambiguous contiguous sequence representing the complete
viral genome from a nasopharyngeal swab of an infected healthcare worker in Cairo, Egypt. The genome has all typical features of SARS-CoV-2 genomes, with no protein-disrupting mutations; however, three mutations are worth highlighting and future tracking:
a synonymous mutation causing a rare spike S-813-I variation) and two less frequent ones leading to an A41V variation in NSP3, encoded by ORF1a, and a Q677H variation in the spike protein. Both affected proteins, S and NSP3, are relevant to vaccine and drug
development. |
|
|
Song, K, Gong, et al |
Cancer |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of the current study was to determine whether recent oncologic treatment is associated with a higher
risk of death among patients with carcinoma who are hospitalized with COVID-19. Data regarding 248 consecutive patients with carcinoma hospitalized with COVID-19 were collected retrospectively from 33 hospitals in Hubei Province, China, from January 1, 2020,
to March 25, 2020. Compared with patients without receipt of recent oncologic treatment, the mortality rate of patients who recently received oncologic treatment was significantly higher. After controlling for confounders, recent receipt of chemotherapy, surgery,
and radiotherapy were identified as independently associated with a higher risk of death. |
|
|
Staples, L, Nielssen, et al |
Internet Interv |
Mental Health |
|
Demand for digital mental health services (DMHS) has increased during COVID-19, among Australians. An initial demand
in service demand, anxiety, and concern about COVID-19 were observed. |
|
|
Stear, Benjamin, Hernandez, et al |
medRxiv |
Epidemiology| Épidémiologie |
This pandemic has strained public health systems in many states, leading to extended delays in reporting deaths to
the US Centers for Disease Control National Center for Health Statistics (NCHS), as well as rumors about the accuracy of reported data. To assess these concerns, we have adapted simple financial statistics to evaluate possible anomalies in mortality data and
applied them to NCHS and US Centers for Disease Control Case Surveillance (CS) datasets. NCHS data released 21 October record almost 8000 more deaths from COVID-19 in March and April, US wide, than are captured in the CS daily provisional counts of COVID-19
deaths during those months. For five consecutive weeks during June, July, and August, the states Alabama, California, Florida, Georgia, and Texas each reported at least 40 more deaths per week to the NCHS than were captured in CS daily counts for the same
period, with Florida and Texas reporting over 1000 and 4000 more COVID-19 deaths, respectively. In contrast, counties in multiple states attribute to COVID-19 fewer than 10% of deaths reported to the NCHS over the period February-September 2020, while simultaneously
reporting over twice as many deaths from all causes compared to the same period in previous years. |
|
|
Sun, H, Liu, et al |
American Journal of Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to determine if COVID-19 changed ED visit disease severity during the pandemic. The
COVID-19 outbreak has been associated with decreases in ED visits in Nanjing, China, but increases in the proportion of severe ED visits. |
|
|
Surek, A, Ferahman, et al |
Eur J Trauma Emerg Surg |
Healthcare Response | Réponse des soins de santé |
The aim of this paper is to investigate the effect of COVID-19 pandemic on general surgical emergencies as well as
analyzing the effectiveness of measures taken in reducing the incidence of COVID-19 in patients and healthcare professionals. There was a 59.1% reduction in emergency surgeries. The results of COVID-19 screening were positive in 6 (6/103, 5.82%) patients
undergoing emergency surgery. None of the doctors working in the ward were infected with COVID-19 infection (0/20). The screening tests were positive in only two nurses working on the ward (2/24, 8.33%). |
|
|
Surti, M, Patel, et al |
RSC Advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study, the inhibitory prospects of ilimaquinone (marine sponge metabolite) were assessed in comparison with
hydroxychloroquine, azithromycin, favipiravir, ivermectin and remdesivir at the active binding pockets of nine different vital SARS-CoV-2 target proteins (spike receptor binding domain, RNA-dependent RNA polymerase, Nsp10, Nsp13, Nsp14, Nsp15, Nsp16, main
protease, and papain-like-protease), employing an in silico molecular interaction based approach. |
|
|
Suzuki, Y, Kasashima, et al |
Geriatric Orthopaedic Surgery and Rehabilitation |
Clinical data| Données cliniques |
An 87-year-old Japanese woman was transferred to our emergency room with a right hip pain after she fell. Then, qualitative
real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) was carried out and turned out to be positive. She was diagnosed right femoral intertrochanteric fracture with concomitant COVID-19 infection. |
|
|
Szente Fonseca, SN, Queiroz de Sousa, et al |
Travel Med Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In a sample of Brazilian COVID-19 adult cases (n=717) presenting in ER, the use of hydroxychloroquine (HCQ), prednisone
or both significantly reduced hospitalization risk by 50-60%. Ivermectin, azithromycin and oseltamivir did not substantially reduce risk further. Hospitalization risk was doubled for people with type-2 diabetes or obesity, increased by two-thirds for people
with heart disease, and by 75% for each decade of age over age 40. Similar magnitudes of reduced risk with HCQ and prednisone use were seen for mortality risk, though were not significant |
|
|
Tadesse, T, Alemu, et al |
Infection and Drug Resistance |
Public Health response| Interventions de santé publique |
This study investigated the predictors of COVID-19 prevention practice using the Health Belief Model among employees
in Addis Ababa, Ethiopia, 2020. Methods: Multicentre cross-sectional study design was used. A total of 628 employees selected by systematic sampling method were included in this study. Data were collected using a pretested self-administered questionnaire.
Results: From a total of 628 respondents, 432 of them had poor COVID-19 prevention practice. Three hundred ninety-one (62.3%), 337 (53.7%), 312 (49.7), 497 (79.1%), 303 (48.2%) and 299 (52.4%) of the respondents had high perceived susceptibility, severity,
benefit, barrier, cues to action and self-efficacy to COVID-19 prevention practice, respectively. Employees with a low level of perceived barriers were less likely to have a poor practice of COVID-19 prevention compared to employees with a high level of perceived
barrier. |
|
|
Tai, TT, Wu, et al |
Clin Transl Sci |
Therapeutics| Thérapeutique Animal model | Modèle animal |
This article describes a pre-clinical study to investigate the pharmacokinetics of a novel formulation of liposomal
HCQ administered by intratracheal (IT) instillation in Sprague-Dawley (SD) rats. Compared to unformulated HCQ administered intravenously (IV), liposomal HCQ showed higher (~30-fold) lung exposure, longer (~2.5-fold) half-life in lung, but lower blood exposure
with ~20% of C(max) and 74% of AUC(0-72) and lower heart exposure with 23% of C(max) and 58% of AUC(0-24) (normalized for dose). Similar results were observed relative to IT administration of unformulated HCQ. These pharmacokinetics results in an animal model
demonstrated the proof of concept that inhalable liposomal HCQ may provide clinical benefit and serve as a potential treatment for COVID-19. |
|
|
Takashima, R, Onishi, et al |
Healthcare (Basel) |
Mental Health |
|
The study examined the perceptions of community-dwelling older adults (average 78 yoa) about how COVID-19 restricted
their daily lives via focus-group interviews. Generated themes were: “fear of infection and public, watchful eyes,” “consistency in daily personal life,” “pain from reducing my social life,” “readiness to endure a restricted life,” “awareness of positive changes
in myself,” and “concern for a languishing society.” There was no change that would make their lives untenable, and they continued their daily personal lives at a minimum level. However, everyone's social lives were reduced, which over the long term can lead
to a lost sense of purpose in life. |
|
|
Thaunat, O, Legeai, et al |
Kidney Int |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
Retrospectively evaluated the decision to suspend kidney transplantation during the first epidemic wave of COVID-19
in France, by comparing the overall and COVID-19 related mortality in kidney transplant recipients and candidate populations over the previous three years. In both populations, an excess of deaths, integrally explained by COVID-19, was observed. |
|
|
COVID-19 disparity among racial and ethnic minorities in the US: A cross sectional
analysis |
Tirupathi, R, Muradova, et al |
Travel Med Infect Dis |
Epidemiology| Épidémiologie |
Analyze racial disparities in Coronavirus disease (COVID-19) cases in the US. Infection incidence and mortality were
found to be higher among African Americans and among Latinos disproportionately higher than their representation in most states. |
|
Toledo, I, Barahona, et al |
Revista Chilena de Anestesia |
Clinical data| Données cliniques |
In this article, we report and discuss the case of a 59-year-old patient with diabetes mellitus ii, Chronic Arterial
Hypertension, Gout, and Stage iv Chronic Renal Failure admitted with a multifocal septic condition characterized by suppurative collections including a large subcutaneous lumbar abscess recently drained. The patient evolved with left knee septic arthritis
and was scheduled for arthroscopic irrigation and debridement. As per protocol a SARS-COv2 PCR was tested and resulted positive. |
|
|
Tong, Y, Bao, et al |
J Transl Med |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Discharged cases with COVID-19 (n=1008) were selected to detect SARS-CoV-2 RNA in isolation period via 7 types of specimens
by RT-qPCR before releasing from the isolation period. Of investigated cases, the nasopharyngeal swab specimens showed the highest positive rate of SARS-CoV-2 RNA (71.06%), followed by alveolar lavage fluid (66.67%), oropharyngeal swab (30.77%), sputum (28.53%),
urine (16.30%), blood (12.5%), stool (12.21%), anal swab (11.22%) and corneal secretion (2.99%); viral RNA couldn’t be detected in other types of specimen in this study. |
|
|
Triberti, S, Durosini, et al |
Personality and Individual Differences |
Mental Health |
|
465 participants filled in an online questionnaire on their experience and behavior during the first weeks of the quarantine,
and on antisocial personality. Results suggest that it is possible that non-conforming to recommendations is not influenced by aggression, but by individuals persevering in their activities independently of the quarantine, consistently with machiavellianism. |
|
|
Photocatalyst under visible light irradiation inactivates
SARS-CoV-2 on an abiotic surface |
Uema, Masashi, Yonemitsu, et al |
bioRxiv |
Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
Here we examined the effectiveness of visible light-responsive photocatalyst RENECAT on the inactivation of SARS-CoV-2
under different temperatures and exposure durations. The viral activation on the photocatalyst-coated glass slides decreased from 5.93∓0.38
logTCID50/ml to 3.05∓ 0.25 logTCID50/ml after exposure to
visible light irradiation for 6h at 20 degree C. On the other hand, lighting without the photocatalyst, or the photocatalyst-coat without lighting retained viral stability. Immunoblotting and electron microscopic analyses showed the reduced amounts of spike
protein on the viral surface after the photocatalyst treatment. |
|
Uphaus, T, Gröschel, et al |
Frontiers in Neurology |
Healthcare Response | Réponse des soins de santé |
Authors aim to determine whether the COVID-19 pandemic is affecting utilization of recanalization procedures and numbers
of patients with stroke and TIA admitted to a primary care stroke center. During the COVID-19 pandemic, resources of the healthcare system in a primary care university hospital in Germany still allowed for unchanged numbers of recanalization procedures due
to ischemic stroke. |
|
|
V S, P, Ittamalla, et al |
International Journal of Pervasive Computing and Communications |
Public Health response| Interventions de santé publique |
The purpose of this paper is to analyze, using machine learning, how different continents have different sentiments
over digital contact tracing being used as a measure to curb COVID-19. This study was conducted in two parts. Study one results show that North American and European citizens share more negative sentiments toward “digital contact tracing.” The citizens of
the Asian and South American continent mostly share neutral sentiments regarding the digital contact tracing. Overall, only 33% of total tweets were positively related to contact tracing, whereas 52% of the total tweets were neutral. Study two results show
that factors such as fear of government using contact tracing to spy on its people, the feeling of being unsafe and contact tracing being used to promote an agenda were the three major issues concerning the overall general public. |
|
|
van der Wal, Lea Imeen |
Research Square prepub |
Clinical data| Données cliniques |
We conducted an observational cohort study in 19 Intensive Care Unit (ICU) patients with COVID-19 and computed tomography
(CT) scanning proven pulmonary embolism. Unfractionated heparin resulted in clinical success in at least 14 out of 19 patients. Pulmonary emboli were completely resolved on the follow up computed tomography scans in 5 out of 6 patients and partly resolved
in the 6th patient. In this observational study, we showed a rapid clinical, laboratory and radiological improvement in patients with COVID-19 and proven pulmonary embolism. Standard anticoagulant treatment was effective in this setting, supporting current
guideline recommendations. |
|
|
Vankadari, N, Jeyasankar, et al |
J Phys Chem Lett |
Coronavirology| Coronavirologie |
The authors report the novel structure of Nsp1 from SARS-CoV-2 in complex with the SL1 region of 5'UTR of SARS-CoV-2,
and its factual interaction is corroborated with enzyme kinetics and experimental binding affinity studies. The studies also address how leader protein Nsp1 of SARS-CoV-2 recognizes its self RNA toward translational regulation by further recruitment of the
40S ribosome. With the aid of molecular dynamics and simulations, we also demonstrated the real-time stability and functional dynamics of the Nsp1/SL1 complex. The studies also report the potential inhibitors and their mode of action to block viral protein/RNA
complex formation. This enhance our understanding of the mechanism of the first viral protein Nsp1 synthesized in the human cell to regulate the translation of self and host. Understanding the structure and mechanism of SARS-CoV-2 Nsp1 and its interplay with
the viral RNA and ribosome will open the arena for exploring the development of live attenuated vaccines and effective therapeutic targets for this disease. |
|
|
Identifying Fine-Grained Opinion and Classifying Polarity on Coronavirus Pandemic |
Vargas, FA, Dos Santos, et al |
|
Public Health response| Interventions de santé publique |
Authors explore the fine-grained opinion identification and polarity classification tasks using twitter data on the
COVID-19 pandemic in Brazilian Portuguese. They found that the cross-domain data improved the results of the polarity classification. |
|
Vasques, F, Sanderson, et al |
Intensive Care Med |
Clinical data| Données cliniques |
To describe estimated indices of physiological dead space—and their association with respiratory mechanics, severity
of hypoxaemia, biomarkers, and outcomes—we performed a retrospective analysis of adult patients with COVID-19 respiratory failure requiring mechanical ventilation in four medical Intensive Care Units (ICU) within Guy’s and St Thomas’ NHS Trust—London, UK.
Data suggest that increased physiological dead space is a characteristic of patients with COVID-19 acute hypoxemic respiratory failure (AHRF), with no relation with compliance of the respiratory system. Given that both PaO2/FiO2 and physiological dead space
are worse in non-survivors, it is unclear if dead space is independently associated with mortality or if its effect on outcome is mediated through hypoxaemia. |
|
|
Vidal, PlácidoL, de Moura, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Developed a novel fully automatic methodology specially designed for the identification of these lung regions in X-ray
images of low quality as those from portable devices. To do so, we took advantage of a large dataset from magnetic resonance imaging of a similar pathology and performed two stages of transfer learning to obtain a robust methodology with a low number of images
from portable X-ray devices. This way, our methodology obtained a satisfactory accuracy of 0.9761±0.0100 for patients with COVID-19, 0.9801±0.0104 for normal patients and 0.9769±0.0111 for patients with pulmonary diseases with similar characteristics as COVID-19
(such as pneumonia) but not genuine COVID-19. |
|
|
Vijh, R, Ghafari, et al |
American Journal of Infection Control |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
A cross-sectional serological survey of LTC residents and staff members was administered from May 4th to 14th, 2020
at 2 adult LTC facilities located in the Metro Vancouver area, British Columbia that experienced COVID-19 outbreaks in order to evaluate current clinical COVID-19 case definitions. Among the entire study cohort, loss of smell/taste, shortness of breath, headache,
loss of appetite, fatigue, and myalgia were most prominently associated with increased odds of reactive serology. Our serological survey demonstrates that generalized/nonspecific symptoms and repetitive negative NAAT testing are highly associated with seropositivity. |
|
|
In situ pulmonary thrombosis in patients with COVID-19 pneumonia: different
phenotypes may exist |
Wang, L, Chen, et al |
Thrombosis research |
Clinical data| Données cliniques |
We provide details about four intubated patients with severe COVID-19 pneumonia who were diagnosed with PE by computed
tomography pulmonary angiography (CTPA) and who had negative lower extremity venous duplex ultrasounds. All of them had received prophylactic anticoagulation treatment before performing CTPA. Similar to the findings of L.F. van Dam et al., all the thrombotic
lesions in these patients were segmental or subsegmental. However, unlike van dam and colleagues, who reported thrombotic arteries around which there was no apparent consolidation, we found some clogged segmental arteries located just within the consolidation
lesions of the infected lungs We noticed that our patients also had segmental or subsegmental thrombi located in non-consolidation areas. The formation of these thrombi may due to hypercoagulability caused by systemic inflammation since all of the four patients
had a significantly higher level of D-dimer. Therefore, we hypothesize that different phenotypes of in situ thrombosis may exist in patients with COVID-19 pneumonia. |
|
Wang, R, Hu, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
With the spread of COVID-19 worldwide, people¡¯s production and life have been significantly affected. Artificial intelligence
and big data technologies have been vigorously developed in recent years. It is very significant to use data science and technology to help humans in a timely and accurate manner to prevent and control the development of the epidemic, maintain social stability
and assess the impact of the epidemic. This paper explores how data science can play a role from the perspectives of epidemiology, social networking, and economics. In particular, for the existing epidemic model SIR, we present a parameter learning method
using particle swarm optimization (PSO) and the least squares method, and use it to predict the trend of the epidemic. Aiming at the social network data, we provide a specific method to realize sentiment analysis during the epidemic and propose an explainable
fake news detection technique based on a variety of data mining methods. © 2020 IEEE. |
|
|
opvCRISPR: One-pot visual RT-LAMP-CRISPR platform for SARS-cov-2 detection |
Wang, R, Qian, et al |
Biosensors and Bioelectronics |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We propose a one-pot visual SARS-CoV-2 detection system named “opvCRISPR” by integrating reverse transcription loop-mediated
isothermal amplification (RT-LAMP) and Cas12a cleavage in a single reaction system that makes detection results observable with naked eye. The opvCRISPR diagnostic results provide 100% agreement with the Centers for Disease Control and Prevention (CDC)-approved
quantitative RT-PCR assay. |
|
A Bayesian Updating Scheme for Pandemics: Estimating the Infection Dynamics of
COVID-19 |
Wang, S, Yang, et al |
IEEE Computational Intelligence Magazine |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
We propose a Bayesian updating approach for estimating epidemiological parameters using observable information to assess
the impacts of different intervention strategies. We adopt a concise renewal model and propose new parameters by disentangling the reduction of instantaneous reproduction number Rt into mitigation and suppression factors to quantify intervention impacts at
a finer granularity. A statistical analysis framework is built to quantify the impacts of intervention strategies by monitoring the evolution of the estimated parameters. We reveal the intervention impacts in European countries and Wuhan and the resurgence
risk in the United States. |
|
Covid-19-linked
loss of smell and taste: Case study and discussion |
Wang, T |
Journal of Chinese Medicine |
Clinical data| Données cliniques |
Authors report a case of happy hypoxia in a critical COVID-19-positive ICU hospitalized patient who survived from
Indonesia. |
|
Wichmann, D, Atique, et al |
Surg Endosc |
Healthcare Response | Réponse des soins de santé |
This study describes the change in the daily work routine of an Interdisciplinary Endoscopic Unit (IEU) and a prospective
analysis of patients tested positive for SARS-CoV-2 who required endoscopic interventions. Changes in the daily work routine included cancelation of examinations, relocation of staff to other departments, impact of SARS-CoV-2 on medical staff of the IEU, and
supply of protective clothing. Sixteen endoscopic interventions were done in ten patients. In all patients with confirmed infection with SARS-CoV-2, emergency endoscopies were required for relevant bleeding situations. Re-endoscopies were required only in
critically ill COVID-19 patients. The restructuring of processes in the IEU was feasible in short time, effective, and can also be applied broadly at least in developed countries. |
|
|
Happy hypoxia in critical COVID-19 patient: A case report in Tangerang, Indonesia |
Widysanto, A, Wahyuni, et al |
Physiological Reports |
Clinical data| Données cliniques |
Authors report a case of happy hypoxia in a critical COVID-19-positive ICU hospitalized patient who survived from
Indonesia. |
|
Knowledge, attitudes and practices towards COVID-19 amongst ethnic minorities in Hong
Kong |
Wong, CL, Chen, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
This study assessed the knowledge, attitudes and practices (KAP) towards coronavirus disease 2019 (COVID-19) among
South Asians in Hong Kong and examined the factors that affect KAP towards COVID-19 in this population. This cross-sectional descriptive study recruited participants with assistance from South Asian community centres and organisations. A total of 352 participants
completed questionnaires to assess their level of KAP towards COVID-19. The mean knowledge score was 5.38/10, indicating a relatively low knowledge level. The participants expressed certain misconceptions regarding the prevention of COVID-19 infection. They
perceived a mild risk related to the disease, had positive attitudes regarding its prevention and often implemented recommended disease-preventive measures, such as maintaining social distance (88.1%) and wearing masks in public (94.3%). Participants who were
male, had a secondary school education or lower and who perceived a lower risk of being infected and lower self-efficacy were less likely to implement preventive measures. |
|
Wong, F, Collins, et al |
Proc Natl Acad Sci U S A |
Epidemiology| Épidémiologie Transmission |
Authors combine empirical observations of SARS-CoV transmission and extreme value statistics to show that the distribution
of secondary cases is consistent with being fat-tailed, implying large superspreading events are extremal, yet probable, occurrences. These results are integrated with interaction-based network models of disease transmission to show that superspreading, when
it is fat-tailed, leads to pronounced transmission by increasing dispersion. These findings indicate large superspreading events should be the targets of interventions that minimize tail exposure. |
|
|
Impact of the COVID-19 Pandemic on Patterns
of Outpatient Cardiovascular Care |
Wosik, J, Clowse, et al |
Am Heart J |
Healthcare Response | Réponse des soins de santé |
We evaluated ordering patterns during cardiovascular (CV) telehealth clinic visits in the Duke University Health System
between March 15 - June 30, 2020 and 30-day outcomes compared with in-person visits in the same time frame in 2020 and in 2019. Within the Duke University Health System, there was a 33.1% decrease in the number of outpatient CV visits conducted in the first
15 weeks of the COVID-19 pandemic, compared with the same time period in 2019. As a proportion of total visits initially booked, 53% of visits were cancelled in 2020 compared to 35% in 2019. In response to the perceived risks of routine medical care affected
by the COVID-19 pandemic, different phenotypes of patients chose different types of outpatient cardiology care. A better understanding of these differences could help define necessary and appropriate mode of care for cardiology patients. |
|
Wu, Xuelian, Chidimbah Munthali, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
The study aimed to find out about the knowledge, attitudes and preventative practices of COVID-19 among international
students in China during the pandemic. A cross-section survey was conducted among 300 international students from 13 different universities in Hubei province of China between March and April 2020 which relied upon convenience sampling method. Data was collected
through an online Microsoft questionnaire. This study found that social media platform was contributing enormously towards information dissemination and Chinese universities were commended for their continuous notifications on COVID-19 which helped students
to have full knowledge. This, in turn, was instrumental in helping students to form good attitudes and practices towards COVID-19. |
|
|
Wu, Y, Yan, et al |
Health and Place |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to assess how individual and area socioeconomic position and geographical accessibility to healthcare
services were associated with the time to diagnosis among symptomatic COVID-19 patients in Hong Kong. This study found living in public rental housing and living in an area with low education were associated with longer time to diagnosis in the first wave
of infections. No such relations were found in the second wave of infections when the surveillance measures were enhanced. |
|
|
Clinical Features and Temporal Changes of RT-PCR and Chest CT in COVID-19 Pediatric
Patients |
Xia, W, Guo, et al |
Frontiers in Pediatrics |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This work aims to investigate the clinical features and the temporal changes of RT-PCR and CT in COVID-19 pediatric
patients. RT-PCR is more reliable than CT in the initial diagnosis of pediatric patients with COVID-19. |
|
Building the national SARS-CoV-2 laboratory diagnostic capacity in Taiwan |
Yang, JR, Liu, et al |
Health Security |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Two days after the World Health Organization announced the complete viral genome sequence, the national laboratory
of the Taiwan Centers for Disease Control developed a specific real-time reverse transcription polymerase chain reaction (real-time RT-PCR) test for SARS-CoV-2. Test results were obtained within 24 hours, enabling an efficient and rapid control response. |
|
Yang, R, Gui, et al |
Expert Rev Respir Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of the study was to analyze characteristics of asymptomatic/pre-symptomatic patients with SARS-CoV-2
infection. The proportion of normal chest CT in asymptomatic and pre-symptomatic patients with SARS-CoV-2 infection were 35.4% (17/48) and 3.3%(2/61), respectively (P< 0.001). In 17 asymptomatic patients, their images of chest CT maintained normal during the
whole course of diseases, while the normal images of chest CT in 2 pre-symptomatic patients progressed to abnormal later (P< 0.001). In early stage after SARS-CoV-2 infection, images of chest CT and blood tests of asymptomatic patients were different from
pre-symptomatic patients. |
|
|
Bifurcated Autoencoder for Segmentation of COVID-19 Infected Regions in CT Images |
Yazdekhasty, Parham, Zindar, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Propose an approach to segment lung regions infected by COVID-19 to help cardiologists diagnose the disease more accurately,
faster, and more manageable. We propose a bifurcated 2-D model for two types of segmentation. This model uses a shared encoder and a bifurcated connection to two separate decoders. One decoder is for segmentation of the healthy region of the lungs, while the
other is for the segmentation of the infected regions. Experiments on publically available images show that the bifurcated structure segments infected regions of the lungs better than state of the art. |
|
D614G substitution enhances the stability of trimeric
SARS-CoV-2 spike protein |
Yazhini, Arangasamy, Sidhanta, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, using in-silico mutagenesis and energy calculations, we analyzed inter-residue interaction energies and thermodynamic
stability of the dominant (G614) and the ancestral (D614) variants of spike protein trimer in closed and partially open conformations. We find that the local interactions mediated by aspartate at the 614th position are energetically frustrated and create unfavourable
environment. Whereas, glycine at the same position confers energetically favourable environment and strengthens intra- as well as inter-protomer association. Such changes in the local interaction energies enhance the thermodynamic stability of the spike protein
trimer as free energy difference (ΔΔG) upon glycine substitution is -2.6 kcal/mol for closed conformation and -2.0 kcal/mol for open conformation. Our results on the structural and energetic basis of enhanced stability hint that G614 may confer increased availability
of functional form of spike protein trimer and consequent in higher infectivity than the D614 variant. |
|
Treatment of Cytokine Storm in COVID-19
Patients With Immunomodulatory Therapy |
Yessayan, L, Szamosfalvi, et al |
Asaio j |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We report the emergency use of immunomodulatory therapy utilizing an extracorporeal selective cytopheretic device (SCD)
in two patients with elevated serum interleukin (IL)-6 levels and refractory COVID-19 ARDS requiring extracorporeal membrane oxygenation (ECMO). The two enrolled patients' PaO2/FiO2 ratios increased from 55 and 58 to 200 and 192 at 52 and 50 hours, respectively.
Inflammatory indices also declined with IL-6 falling from 231 and 598 pg/ml to 3.32 and 116 pg/ml, respectively. IL-6/IL-10 ratios also decreased from 11.8 and 18 to 0.7 and 0.62, respectively. The two patients were successfully weaned off ECMO after 17 and
16 days of SCD therapy, respectively. |
|
Face Off: Polarized Public Opinions on Personal Face Mask Usage during the COVID-19 Pandemic |
Yeung, Neil, Lai, et al |
arXiv |
Public Health response| Interventions de santé publique |
Propose a novel approach to 1) accurately gauge public sentiment towards face masks in the United States during COVID-19
using a multi-modal demographic inference framework with topic modeling and 2) determine whether face mask policy shifts contributed to polarization towards face masks using offline change point analysis on Twitter data. Experimental results on a large corpus
of Twitter data reveal multiple insights regarding demographic sentiment towards face masks that agree with existing surveys. Furthermore, we find two key policy-shift events contributed to statistically significant changes in sentiment for both Republicans
and Democrats. |
|
Structural basis for repurpose and design of nucleoside
drugs for treating COVID-19 |
Yin, Wanchao, Luan, et al |
bioRxiv |
Therapeutics| Thérapeutique |
Here we report the cryo-EM structures of the viral RdRp in complex with favipiravir and two other nucleoside inhibitor
drugs ribavirin and penciclovir. Moreover, in view of the clinical disadvantages of remdesivir mainly associated with its prodrug form, we designed several orally-available remdesivir parent nucleoside derivatives, including VV16 that showed 5-fold more potent
than remdesivir in inhibition of viral replication. Together, these results demonstrate an unexpected promiscuity of the viral RNA polymerase and provide a basis for repurpose and design of nucleotide analog drugs for COVID-19. |
|
Yoon, JW, Welch, et al |
International Journal of Spine Surgery |
Healthcare Response | Réponse des soins de santé |
Authors propose a novel, remote spinal examination methodology that is easily implemented through telemedicine, where
the patient is an active participant in the successful completion of his or her examination. Implementation of our proposed remote spinal examination has the potential to serve as a guideline for the spine care provider to efficiently assess patients with
spine disease using telemedicine. |
|
|
Yousaf, Z, Siddiqui, et al |
Case Reports in Neurology |
Clinical data| Données cliniques |
A 20-year-old male with COVID-19 who presented with dyspnea and acute confusional state. His initial workup was suggestive
of tuberculous menin-goencephalitis with lymphocytic pleocytosis, high protein in CSF analysis, and suspicious MRI findings, which was later confirmed with a positive CSF culture. |
|
|
Zhan, X, Chen, et al |
Curr Med Res Opin |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Consolidation, pure ground glass opacity (GGO), and multifocal distribution on a CT scan were associated with severe
COVID-19 among examined patients. The dandelion and focal paving stone signs indicate mild COVID-19. |
|
|
An Investigation on the Public's Acceptance of Prevention and Control Measures
for COVID-19 in China |
Zhang, Ao, Wu, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
In this study, the public acceptance questionnaire was designed based on the epidemic prevention measures adopted in
China, to investigate the difference of public acceptance of epidemic prevention measures. The survey data was collected from 2,062 samples with different demographic characteristics from March 8, 2020 to April 9, 2020. The results show that age and educational
level have a significant influence on public acceptance. In contrast gender and occupation field has no significant impact on it. The acceptance of the emergency prevention and control measures taken by the government during the epidemic period is generally
high. With the development of the epidemic, the acceptability is increasing. |
|
Zhang, B, Dong, et al |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
Clinical data| Données cliniques |
This study aimed to explore the association of the TG/HDL-C ratio with cardiovascular risk and prognosis in COVID-19.
Increased TG/HDL-C ratio was independently associated with myocardial injury, heart failure, disease severity, and mortality in patients with COVID-19, and it may be a useful marker for early identification of patients with high risk and poor outcome. |
|
|
Associations between air pollution and COVID-19 epidemic during quarantine period
in China |
Zhang, X, Tang, et al |
Environmental Pollution |
Epidemiology| Épidémiologie |
In this study we assessedthe association between short-term exposure to air pollution and daily confirmed cases of
COVID-19 in 235 Chinese cities. Significant positive associations of short-term exposure to air pollutants with daily new confirmed cases were observed during the epidemic. |
|
Comparing Machine Learning Algorithms with or without Feature Extraction for DNA Classification |
Zhang, Xiangxie, Beinke, et al |
arXiv |
Coronavirology| Coronavirologie |
The classification of DNA sequences is a key research area in bioinformatics as it enables researchers to conduct genomic
analysis and detect possible diseases. In this paper, three state-of-the-art algorithms, namely Convolutional Neural Networks, Deep Neural Networks, and N-gram Probabilistic Models, are used for the task of DNA classification. Furthermore, we introduce a novel
feature extraction method based on the Levenshtein distance and randomly generated DNA sub-sequences to compute information-rich features from the DNA sequences. We also use an existing feature extraction method based on 3-grams to represent amino acids and
combine both feature extraction methods with a multitude of machine learning algorithms. Four different data sets, each concerning viral diseases such as Covid-19, AIDS, Influenza, and Hepatitis C, are used for evaluating the different approaches. The results
of the experiments show that all methods obtain high accuracies on the different DNA datasets. Furthermore, the domain-specific 3-gram feature extraction method leads in general to the best results in the experiments, while the newly proposed technique outperforms
all other methods on the smallest Covid-19 dataset |
|
Efficacy of traditional
chinese medicine for covid-19 pneumonia: Two case reports |
Zheng, Z, Ma, et al |
Journal of Chinese Medicine |
Clinical data| Données cliniques |
The treatment of viral conditions is well established within the context of Chinese Medicine. Here we report two successful
cases, including CT scans of the patient’s chest and temperature charts from before, during and after treatment to demonstrate the benefits achieved. Because traditional Chinese medicine (TCM) shows a positive effect in the treatment of COVID-19, it is highly
recommended that TCM is incorporated early in the treatment of patients affected by this disease. |
|
Health Perceptions and Misconceptions Regarding COVID-19 in China: Online Survey Study |
Zhou, J, Ghose, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
Assesses public health perceptions and misunderstandings about COVID-19 in China. The study finds multiple information
channels can improve public health perception and the identification of misleading information during the COVID-19 pandemic. Videos on social media increased the risk of rumor propagation among vulnerable groups. |
|
Zhou, Y, Chen, et al |
Biosensors and Bioelectronics |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This work provides a reliable signal amplification platform to dramatically enhance the sensitivity of AuNP-LFS for
rapid and accurate diagnostics of various infectious diseases. |
|
|
Zingone, F, Siniscalchi, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
This study aimed to analyze the perception of the COVID-19 emergency among patients with inflammatory bowel disease
(IBD) during the early weeks of the lockdown. The results of our survey demonstrate that the lockdown had a significant impact on the psychological aspects of patients with IBD and suggest the need for increasing communication with patients with IBD (eg, through
telemedicine) to ensure patients receive adequate health care, correct information, and proper psychological support. |
|
|
Robust SARS-CoV-2-specific T-cell immunity is maintained
at 6 months following primary infection |
Zuo, Jianmin, Dowell, et al |
bioRxiv |
Immunology | Immunologie |
We analysed the magnitude and phenotype of the SARS-CoV-2 cellular immune response in 100 donors at six months following
primary infection and related this to the profile of antibody level against spike, nucleoprotein and RBD over the previous six months. Median T-cell responses were 50% higher in donors who had experienced an initial symptomatic infection indicating that the
severity of primary infection establishes a set-point for cellular immunity that lasts for at least 6 months. |
|
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19 |
Zuo, Y, Estes, et al |
Sci Transl Med |
Clinical data| Données cliniques Immunology | Immunologie Animal model | Modèle animal |
Here, we measured eight types of autoantibodies targeting phospholipids and phospholipid-binding proteins (aPL antibodies)
in serum samples from 172 patients hospitalized with COVID-19. We detected aPS/PT IgG in 24% of serum samples, anticardiolipin IgM in 23% of samples, and aPS/PT IgM in 18% of samples. Antiphospholipid autoantibodies were present in 52% of serum samples using
the manufacturer's threshold and in 30% using a more stringent cutoff (≥40 ELISA-specific units). Higher titers of aPL antibodies were associated with neutrophil hyperactivity including the release of neutrophil extracellular traps (NETs), higher platelet
counts, more severe respiratory disease, and lower clinical estimated glomerular filtration rate. Similar to IgG from patients with antiphospholipid syndrome, IgG fractions isolated from COVID-19 patients promoted NET release from neutrophils isolated from
healthy individuals. Furthermore, injection of IgG purified from COVID-19 patient serum into mice accelerated venous thrombosis in two mouse models. |
|
Acosta, CM, Acosta, et al |
Revista Chilena de Anestesia |
Review Literature| Revue de littérature |
|
|
|
Al Deek, NF, Wei, et al |
Plastic and Reconstructive Surgery - Global Open |
Review Literature| Revue de littérature |
|
|
|
Al-Tabba, A, Al-Hussaini, et al |
Frontiers in Medicine |
Review Literature| Revue de littérature |
|
|
|
Anderson, AE, Justement, et al |
Biochem Mol Biol Educ |
Review Literature| Revue de littérature |
|
|
|
Safeguarding adults practice and remote working in the COVID-19 era: challenges and opportunities |
Anka, A, Thacker, et al |
Journal of Adult Protection |
Review Literature| Revue de littérature |
|
|
Ayele Mega, T, Feyissa, et al |
Canadian respiratory journal |
Review Literature| Revue de littérature |
SR-MA: Data Source. PubMed, Cochrane CENTRAL, LITCOVID, Web of Science, SCOPUS, BioRxiv, Embase, MedRxiv, and Wiley
online library were searched from 2019/12/30 to 2020/05/23. This meta-analysis and systematic review, which included a limited number of poorly designed studies of patients with COVID-19, revealed HCQ is intolerable, unsafe, and not efficacious. Similarly,
HCQ + AZ combination was not different from HCQ alone in curbing mortality and ICU admission. |
|
|
PMC7491991; Effects of Coronavirus Disease 2019 on Solid Organ Transplantation |
Aziz, H, Lashkari, et al |
Transplant Proc |
Review Literature| Revue de littérature |
|
|
Influenza virus and coronavirus: Cellular binding and internalization |
Bao, MM, Yang, et al |
Wuli Xuebao/Acta Physica Sinica |
Review Literature| Revue de littérature |
|
|
Bellocchio, L, Bordea, et al |
Int J Environ Res Public Health |
Review Literature| Revue de littérature |
|
|
|
The SARS-CoV-2 spike protein: balancing stability and infectivity |
Berger, I, Schaffitzel, et al |
Cell Res |
Review Literature| Revue de littérature |
|
|
There is
a Role in Detection of SARS-CoV-2 in Conjunctiva and Tears: a comprehensive review |
Bernabei, F, Versura, et al |
New Microbiol |
Review Literature| Revue de littérature |
|
|
Bier-Laning, C, Cramer, et al |
Otolaryngol Head Neck Surg |
Review Literature| Revue de littérature |
|
|
|
Changes in physiology and immune system during pregnancy and coronavirus infection: A review |
Chen, M, Zeng, et al |
European Journal of Obstetrics and Gynecology and Reproductive Biology |
Review Literature| Revue de littérature |
|
|
Intracranial hemorrhage in coronavirus disease 2019 (COVID-19) patients |
Cheruiyot, I, Sehmi, et al |
Neurol Sci |
Review Literature| Revue de littérature |
|
|
Targeting Neutrophils to Treat Acute Respiratory Distress Syndrome in Coronavirus Disease |
Chiang, CC, Korinek, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
|
|
Comparative epidemiology between the 2009 H1N1 influenza and COVID-19 pandemics |
da Costa, VG, Saivish, et al |
Journal of Infection and Public Health |
Review Literature| Revue de littérature |
|
|
de Rivero Vaccari, JC, Dietrich, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
|
|
|
Recent and upcoming
regulatory changes in the European region: Opportunities for medical writers |
Dwivedi, S, Agarwal, et al |
Medical Writing |
Review Literature| Revue de littérature |
|
|
El Bairi, K, Trapani, et al |
European journal of cancer |
Review Literature| Revue de littérature |
|
|
|
Covid-19 outbreak, disruption of dental education, and the role of teledentistry |
Farooq, I, Ali, et al |
Pakistan Journal of Medical Sciences |
Review Literature| Revue de littérature |
|
|
Is there a link between vitamin D status, SARS-CoV-2 infection risk and COVID-19 severity? |
Ferrari, D, Locatelli, et al |
Cell Biochem Funct |
Review Literature| Revue de littérature |
|
|
Fongnzossie Fedoung, Evariste, Biwole, et al |
Research Square prepub |
Review Literature| Revue de littérature |
|
|
|
COVID-19-related mental health effects in the workplace: A narrative review |
Giorgi, G, Lecca, et al |
International Journal of Environmental Research and Public Health |
Review Literature| Revue de littérature |
|
|
Airports and environmental sustainability: A comprehensive review |
Greer, F, Rakas, et al |
Environmental Research Letters |
Review Literature| Revue de littérature |
|
|
Gulec, Fatih, Atakan, et al |
arXiv |
Review Literature| Revue de littérature |
|
|
|
Guo, CC, Mi, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
|
|
|
Guruprasad, L |
Prog Biophys Mol Biol |
Review Literature| Revue de littérature |
|
|
|
He, L, Liu, et al |
Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology |
Review Literature| Revue de littérature |
|
|
|
COVID-19 pandemic and maternal mental health: a systematic review and meta-analysis |
Hessami, K, Romanelli, et al |
J Matern Fetal Neonatal Med |
Review Literature| Revue de littérature |
SR-MA: systematically searched online databases to identify any report on maternal depression during pregnancy or postpartum
using the Edinburgh Postnatal Depression Survey (EPDS) and maternal anxiety using the State-Trait Anxiety Inventory (STAI) until 5th July 2020. The present meta-analysis provides evidence that the COVID-19 pandemic significantly increases the risk of anxiety
among women during pregnancy and perinatal period. Support measures should be considered for women during pregnancy or perinatal period to guarantee mental health for this susceptible population. |
|
Hoang, T |
J Med Virol |
Review Literature| Revue de littérature |
SR-MA: PubMed and Embase were searched until September 2020. This study provided up-to-date evidence of several clinical
and epidemiological characteristics in the association with COVID-19 recurrence cases. Further in-depth analyses for the causal effect of factors on re-positive viral RNA are needed for the management of discharged patients with COVID-19. This article is protected
by copyright. All rights reserved. |
|
|
Hodnik, JJ, Ježek, et al |
Trop Anim Health Prod |
Review Literature| Revue de littérature |
|
|
|
PMC7583620; Covid-19 and surgery: Challenging issues in the face of new normal - A narrative review |
Huda, F, Kumar, et al |
Ann Med Surg (Lond) |
Review Literature| Revue de littérature |
|
|
Current status on treatment options for feline infectious peritonitis and SARS-CoV-2 positive
cats |
Izes, AM, Yu, et al |
Vet Q |
Review Literature| Revue de littérature |
|
|
The
in vitro diagnostics regulation and the role of medical writers |
Jawdekar-Abraham, G, Billiones, et al |
Medical Writing |
Review Literature| Revue de littérature |
|
|
Molecular Pathogenesis and Treatment Approaches of COVID-19
– A Comprehensive Review |
Jha, Niraj Kumar, Dua, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
|
|
Kar, SK, Oyetunji, et al |
Neurology Psychiatry and Brain Research |
Review Literature| Revue de littérature |
ScR: search was conducted in the PubMed and PubMed Central databases using the terms “mental health,” "psychiatric
disorders," "COVID-19", “coronavirus,” "Asia," “Africa,” "Lower Middle-income countries." All articles published in the English language until 3rd July 2020 were included. |
|
|
Karl, JP |
Mil Med |
Review Literature| Revue de littérature |
|
|
|
Appropriate orthodontic appliances during the COVID-19 pandemic: A scoping review |
Kaur, H, Kochhar, et al |
Journal of Oral Biology and Craniofacial Research |
Review Literature| Revue de littérature |
ScR: Electronic databases (PubMed, Scopus, Web of Science, Science Direct, and Google Scholar) were searched up until
August 11, 2020. Subject to regional demands, CAT can be considered as the relatively safer modality-predictable and effective apposite to fixed orthodontic appliances in these unprecedented times.
|
|
The Power of Augmented Reality and Artificial Intelligence During the Covid-19 Outbreak |
Kerdvibulvech, C, Chen, et al |
|
Review Literature| Revue de littérature |
|
|
Kim, MY, Brennan, et al |
Current Transplantation Reports |
Review Literature| Revue de littérature |
|
|
|
Kulkarni, S |
J Hum Hypertens |
Review Literature| Revue de littérature |
|
|
|
Emerging Technologies and Sensors That Can Be Used during the COVID-19 Pandemic |
Kumar, SS |
|
Review Literature| Revue de littérature |
|
|
Lam, JKW, Cheung, et al |
Adv Drug Deliv Rev |
Review Literature| Revue de littérature |
|
|
|
Lat, TI, Patel, et al |
Am J Obstet Gynecol MFM |
Review Literature| Revue de littérature |
|
|
|
Chest CT findings in patients with coronavirus disease 2019 (COVID-19): a comprehensive review |
Li, J, Yan, et al |
Diagn Interv Radiol |
Review Literature| Revue de littérature |
|
|
Lim, ZJ, Reddy, et al |
Resuscitation |
Review Literature| Revue de littérature |
SR-MA: systematic review of PubMed, EMBASE, and pre-print websites was performed. The incidence and mortality following
OHCA was higher during the COVID-19 pandemic. There were significant variations in resuscitation practices during the pandemic. Research to define optimal processes of pre-hospital care during a pandemic is urgently required.
|
|
|
COVID-19 Basics and Vaccine Development with a Canadian Perspective |
Liu, M, Chen, et al |
Can J Microbiol |
Review Literature| Revue de littérature |
|
|
ACE2, the kidney and the emergence of COVID-19 two decades after ACE2 discovery |
Lores, E, Wysocki, et al |
Clin Sci (Lond) |
Review Literature| Revue de littérature |
|
|
Ma, X, Li, et al |
Kexue Tongbao/Chinese Science Bulletin |
Review Literature| Revue de littérature |
|
|
|
Marano, G, Gaetani, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
|
|
|
Mareev, VY, Orlova, et al |
Kardiologiya |
Review Literature| Revue de littérature |
|
|
|
Mazhar, F, Hadi, et al |
International Journal of Infectious Diseases |
Review Literature| Revue de littérature |
|
|
|
McRobbie, H, Kwan, et al |
Addiction |
Review Literature| Revue de littérature |
|
|
|
Min, J, Sempionatto, et al |
Biosensors and Bioelectronics |
Review Literature| Revue de littérature |
|
|
|
Mohammad, SAS, Osman, et al |
Egyptian Journal of Radiology and Nuclear Medicine |
Review Literature| Revue de littérature |
|
|
|
Moses, MO, Emikpe, et al |
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria |
Review Literature| Revue de littérature |
|
|
|
Tetracycline and viruses: a possible treatment for COVID-19? |
Mosquera-Sulbaran, J, Hernández-Fonseca, et al |
Arch Virol |
Review Literature| Revue de littérature |
|
|
Recent Biotechnological Approaches for Treatment of Novel COVID-19: From Bench to Clinical Trial |
Mousavi, SM, Hashemi, et al |
Drug Metab Rev |
Review Literature| Revue de littérature |
|
|
Nejatifard, M, Asefi, et al |
Cytokine |
Review Literature| Revue de littérature |
SR: databases of PubMed, Cochrane library, and Google Scholar were searched. Our findings revealed that the PBM could
be helpful in reducing the lung inflammation and promoting the regeneration of the damaged tissue. PBM can increase the oxygenation indirectly in order to rehabilitate the affected organs. Thus, the infra-red lasers or light-emitting diodes (LEDs) are recommended
in this regard. |
|
|
[Potential therapeutic drugs for novel coronavirus pneumonia] |
Nie, NF, He, et al |
Zhonghua Jie He He Hu Xi Za Zhi |
Review Literature| Revue de littérature |
|
|
Oladapo, BI, Ismail, et al |
Mater Chem Phys |
Review Literature| Revue de littérature |
|
|
|
33084621; Bromelain: A Review on its Potential as a Therapy for the Management of Covid-19 |
Owoyele, PV, Bakare, et al |
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria |
Review Literature| Revue de littérature |
|
|
Padole, VS, Kalsait, et al |
International Journal of Current Research and Review |
Review Literature| Revue de littérature |
|
|
|
Patiyal, S, Kaur, et al |
Monoclon Antib Immunodiagn Immunother |
Review Literature| Revue de littérature |
|
|
|
Petrides, N, Ismail, et al |
Turk J Urol |
Review Literature| Revue de littérature |
|
|
|
Petrovic, V, Radenkovic, et al |
Frontiers in Physiology |
Review Literature| Revue de littérature |
|
|
|
33090441; Role of troponin in COVID-19 pandemic: a review of literature |
Piccioni, A, Brigida, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
|
|
Pišlar, A, Mitrović, et al |
PLoS Pathog |
Review Literature| Revue de littérature |
|
|
|
PMC7560116; Impact of COVID-19 on people living with HIV: A review |
Prabhu, S, Poongulali, et al |
J Virus Erad |
Review Literature| Revue de littérature |
|
|
Prashanth, K, Manjappa, et al |
European Journal of Molecular and Clinical Medicine |
Review Literature| Revue de littérature |
|
|
|
Pruthi, GD, Parkash, et al |
Journal of Oral Biology and Craniofacial Research |
Review Literature| Revue de littérature |
|
|
|
Tomographic findings in patients with COVID-19 according to evolution of the disease |
Quispe-Cholan, A, Anticona-De-La-Cruz, et al |
Egyptian Journal of Radiology and Nuclear Medicine |
Review Literature| Revue de littérature |
|
|
COVID-19; current scenario in India and convalescent plasma therapy as combating
approach |
Rajan, W, Swaroopa, et al |
Disaster Advances |
Review Literature| Revue de littérature |
|
|
[COVID-19 Pandemic and Mental Health of the General Public: Is there a Tsunami of Mental Disorders?] |
Riedel-Heller, S, Richter, et al |
Psychiatr Prax |
Review Literature| Revue de littérature |
|
|
Roblyer, D |
Journal of Biomedical Optics |
Review Literature| Revue de littérature |
|
|
|
Ryoo, N, Pyun, et al |
J Korean Med Sci |
Review Literature| Revue de littérature |
|
|
|
33085538; Systemic mycoses: a potential alert for complications in COVID-19 patients |
Segrelles-Calvo, G, de S Araújo, et al |
Future microbiology |
Review Literature| Revue de littérature |
|
|
COVID-19: Targeting Proteases in Viral Invasion and Host Immune Response |
Seth, S, Batra, et al |
Frontiers in Molecular Biosciences |
Review Literature| Revue de littérature |
|
|
Sette-de-Souza, PH, Soares Martins, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
|
|
|
Sherwani, S, Khan, et al |
Journal of Inflammation Research |
Review Literature| Revue de littérature |
|
|
|
Mesenchymal stem cells in therapy of coronavirus disease 2019 - a review |
Shi, X, Yu, et al |
Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology |
Review Literature| Revue de littérature |
|
|
Rheumatic Musculoskeletal Diseases and COVID-19 A Review of the First 6 Months of the Pandemic |
Stradner, MH, Dejaco, et al |
Frontiers in Medicine |
Review Literature| Revue de littérature |
|
|
Computational Intelligence Techniques for Combating COVID-19: A Survey |
Tseng, VS, Jia-Ching Ying, et al |
IEEE Computational Intelligence Magazine |
Review Literature| Revue de littérature |
|
|
Reasons
for increasing corona cases during lockdown-case study of india |
Varalakshmi, V, Sarvanan, et al |
Disaster Advances |
Review Literature| Revue de littérature |
|
|
NETosis: Molecular Mechanisms, Role in Physiology and Pathology |
Vorobjeva, NV, Chernyak, et al |
Biochemistry (Moscow) |
Review Literature| Revue de littérature |
|
|
Walker, C, Deb, et al |
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne
des sciences pharmaceutiques |
Review Literature| Revue de littérature |
MA: systematic literature search was performed across PubMed and Embase databases from December 1, 2019 to July 10,
2020. here is significant association between elevated cardiac biomarkers and the severity of COVID-19, which underlines the increased risk of acute cardiac injury with more severe viral infection. This highlights the need to understand the cardiac history
among the COVID-19 patients during initial assessment and for monitoring. |
|
|
Wang, C, Zhang, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
SR-MA: Medline (PubMed), the Web of Science, Embase, and the Cochrane Library were searched for case-control studies
that included data on vein thrombosis in patients with COVID-19 and were published in English, between January 1 and July 25, 2020. As compared with COVID-19 patients with and without thromboembolism, the mortality, ICU treatment rate, and invasive mechanical
ventilation treatment rate of COVID-19 patients with thromboembolism were found to be increased significantly, and the prognosis was worse. |
|
|
Wernly, B, Wernly, et al |
Journal of Public Health (Germany) |
Review Literature| Revue de littérature |
|
|
|
Wower, IK, Brandebourg, et al |
Pathogens |
Review Literature| Revue de littérature |
|
|
|
Youssef, A, Cavalera, et al |
Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie
clinique |
Review Literature| Revue de littérature |
|
|
|
Yüce, M, Filiztekin, et al |
Biosensors and Bioelectronics |
Review Literature| Revue de littérature |
|
|
|
PMC7521878; Topical review on nano-vaccinology: Biochemical promises and key challenges |
Zaheer, T, Pal, et al |
Process Biochem |
Review Literature| Revue de littérature |
|
|
PMC7574840; The impact of COVID-19 pandemic on malaria elimination |
Zawawi, A, Alghanmi, et al |
Parasite Epidemiol Control |
Review Literature| Revue de littérature |
|
|
Zhang, H, Han, et al |
J Natl Cancer Inst |
Review Literature| Revue de littérature |
SR-MA: Our analysis demonstrated that COVID-19 patients with cancer have a higher fatality rate when compared with
that of COVID-19 patients without cancer. Age and gender appear to be risk factors associated with a poorer prognosis. |
|
|
COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms |
Zhong, P, Xu, et al |
Signal Transduct Target Ther |
Review Literature| Revue de littérature |
|
|
33081906; Research progress of coagulation dysfunction in coronavirus disease 2019 |
Zhong, S, Wu, et al |
Zhonghua wei zhong bing ji jiu yi xue |
Review Literature| Revue de littérature |
|
|
Abrams, EM, t Jong, et al |
Cmaj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Acosta, LMY |
Linacre Quarterly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ahir, S, Telavane, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ahmad, N, Chauhan, et al |
Computer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Airhihenbuwa, CO |
Health Promot Pract |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33090438; Impact of COVID-19 on the cerebrovascular system and the prevention of RBC lysis |
Akhter, N, Ahmad, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Aktug, ZB, Demir, et al |
Pakistan Journal of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Al Amin, S, Morrison, et al |
N C Med J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
New Perspectives on Antimicrobial Agents: Remdesivir Treatment for COVID-19 |
Aleissa, MM, Silverman, et al |
Antimicrob Agents Chemother |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Alexander, B, Baranchuk, et al |
Circulation.Arrhythmia and electrophysiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Alhouti, I |
Journal of Professional Capital and Community |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The impact of COVID-19 on manuscript submissions to Pediatric Research |
Alkhouri, NB, Mutka, et al |
Pediatr Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Allegrini, D, Raimondi, et al |
Eur J Ophthalmol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Virtual bedside concerts for patients with COVID-19: a trio of perspectives |
Ambler, M, Wodecki, et al |
Cmaj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Anaikatti, P, Sheth, et al |
Emerg Med Australas |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Immune responses to corona family viruses and vaccine strategies |
Andalib, A |
Journal of Isfahan Medical School |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nursing Home Design and COVID-19: Balancing Infection Control, Quality of Life, and Resilience |
Anderson, DC, Grey, et al |
J Am Med Dir Assoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Physical activity and mental health in Covid-19 times: an editorial |
Antunes, R, Frontini, et al |
Sleep medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cardiopulmonary resuscitation in coronavirus SARS-CoV-2 patients in supine and prone positions |
Argüello-López, B, Navarro-Vargas, et al |
Revista Chilena de Anestesia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Armstrong, D, Moore, et al |
Med Care Res Rev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Arshad, A, Dennison, et al |
Br J Cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ashcroft, J, Davies, et al |
Surgeon |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19 Crisis Communications: The Challenge for Environmental Organizations |
Auer, MR |
Environmental Science and Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Detection of novel coronavirus (SARS-CoV-2) RNA in peripheral blood specimens |
Azghandi, M, Kerachian, et al |
J Transl Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Balfour, ME, Curtis, et al |
Psychiatr Serv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pragmatic trials with prespecified subgroups: what oncologists can learn from COVID-19 |
Banerjee, R, Prasad, et al |
Nat Rev Clin Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Response to "Tomographic Findings and Thrombogenic Effects of COVID-19" |
Bao, C, Liu, et al |
J Am Coll Radiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Using the lessons of COVID-19 to improve access to physical therapists for people with cancer |
Barnes, CA, Durham, et al |
Rehabilitation Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Barros, Michael Taynnan, Veletic, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pandemic Care Through Collaboration: Lessons From a COVID-19 Field Hospital |
Baughman, AW, Hirschberg, et al |
J Am Med Dir Assoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Baumer, Y, Farmer, et al |
Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Harms of public health interventions against covid-19 must not be ignored |
Bavli, I, Sutton, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bawidamann, L, Peter, et al |
European Societies |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7560115; Decreased incidence of preterm birth during coronavirus disease 2019 pandemic |
Berghella, V, Boelig, et al |
Am J Obstet Gynecol MFM |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Beys-da-Silva, WO, da Rosa, et al |
Biochim Biophys Acta Mol Basis Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Oral lesions in COVID-19 infection: is long term follow-up important in the affected patients? |
Bezerra, TMM, de Brito Monteiro, et al |
Oral Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Binello, N, Garrasi, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Biss, M |
Journal of Communication in Healthcare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Blitz, MJ, Rochelson, et al |
Am J Obstet Gynecol MFM |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ac2-26 mimetic peptide of annexin A1 to treat severe COVID-19: A hypothesis |
Bonavita, AG |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bonfá, E, Gossec, et al |
Nat Rev Rheumatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Why Severe COVID-19 Patients Are at Greater Risk of Developing Depression: A Molecular Perspective |
Bouças, AP, Rheinheimer, et al |
Neuroscientist |
Commentary/Editorial| Commentaire/Éditorial |
|
|
33080038; R2N and the use of alternative methods in COVID-19 research |
Boyle, EC, Bleich, et al |
ALTEX |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Boyles, GP, Thung, et al |
Am J Obstet Gynecol MFM |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Interleukin-6: Molecule in the intersection of cancer, ageing and COVID-19 |
Brábek, J, Jakubek, et al |
International Journal of Molecular Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Brinkley, A, Jorgensen, et al |
Psychiatr Serv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Brooks, DJ, Saad, et al |
Politics and Gender |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Responsible innovation in synthetic biology in response to COVID-19: the role of data positionality |
Bruynseels, K |
Ethics and Information Technology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bugatti, S, De Stefano, et al |
RMD open |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A Pediatric Strategy for the Next Phase of the SARS–CoV-2 Pandemic |
Buonsenso, D, Valentini, et al |
Frontiers in Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Capobussi, M, Moja, et al |
3D Print Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chandrasekaran, S, Diamond-Smith, et al |
Stud Fam Plann |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chen, CH, Chen, et al |
J Hosp Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chen, Y, Klein, et al |
Ageing Res Rev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Myopericaditis as a late manifestation of the probable COVID-19 |
Chikhireva, LN, Chikhirev, et al |
Kardiologiya |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Specificity and cross-reactivity of a test for anti-SARS-CoV-2 antibodies |
Choy, KW |
Lancet Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Clark, J, Donai, et al |
Hearing Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cleary, SJ, Magnen, et al |
Br J Pharmacol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cloke, J |
Eurasian Geography and Economics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Reply to: Say What?! Ableist logic used in misguided attempt to combat ageism during COVID-19 |
Colenda, CC, Reynolds, et al |
J Am Geriatr Soc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Three-Tiered COVID-19 Cohorting Strategy and Implications for Memory-Care |
Collison, M, Beiting, et al |
J Am Med Dir Assoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Reporting of sexually transmitted infections during the COVID-19 pandemic |
Crane, MA, Popovic, et al |
Sex Transm Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Crispo, MM, Strout, et al |
J Pain Symptom Manage |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cronin, S, Piacquadio, et al |
Am J Obstet Gynecol MFM |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Past Decade of Paying for Value : From the Affordable Care Act to COVID-19 |
Crook, H, Whitaker, et al |
N C Med J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nursing Home Resident Weight Loss During Coronavirus Disease 2019 Restrictions |
Danilovich, MK, Norrick, et al |
J Am Med Dir Assoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Social Distancing and Cultural Bias: On the Spatiality of COVID-19 |
Davy, B |
Journal of the American Planning Association |
Commentary/Editorial| Commentaire/Éditorial |
|
|
de Falco, SE, Renzi, et al |
Entrepreneurship Research Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A Web-based Information System for the Management of ICU Beds during the Coronavirus Outbreak |
De Morais Barroca Filho, I, Sampaio, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
De Roux, Q, Delage, et al |
Asaio j |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Acupuncture
for NHS staff during the coronavirus pandemic: A unique project |
Deadman, P, Levy, et al |
Journal of Chinese Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Dean, E |
Nursing management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
DeJohn, C |
Aerospace Medicine and Human Performance |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Dellapiana, G, Naqvi, et al |
Am J Obstet Gynecol MFM |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Demirci, JR |
The Journal of perinatal & neonatal nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Airport landside sustainable capacity and level of service of terminal functional subsystems |
Di Mascio, P, Moretti, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Realizing environmentally conscious manufacturing in the post–COVID-19 era |
Diaz-Elsayed, N, Morris, et al |
Smart and Sustainable Manufacturing Systems |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: A Digital Transformation Approach to a Public Primary Healthcare Environment |
Do Nascimento, MG, Iorio, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Drouin, JS, Chigbo, et al |
Rehabilitation Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Durán-Muñoz-Cruzado, VM, Pareja-Ciuró, et al |
Medicina clinica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7578699; The local governance of COVID-19: Disease prevention and social security in rural
India |
Dutta, A, Fischer, et al |
World Dev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7454300; Elbogen et al. Respond to "Stressors and Suicide Attempts in a Time of COVID-19" |
Elbogen, EB, Lanier, et al |
Am J Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Elmaraghi, S, Rao, et al |
WMJ : official publication of the State Medical Society of Wisconsin |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Dentistry and Covid-19 pandemic:
operative indications post-lockdown |
Enrico, G, Elisabetta, et al |
New Microbiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Estella, Á, Garnacho-Montero, et al |
Med Intensiva |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Facharztmagazine, R |
MMW Fortschr Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Farris, AD, Guthridge, et al |
Nat Immunol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Favaloro, EJ, Lippi, et al |
Seminars in thrombosis and hemostasis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Medical Simulation: The Least Advertised and Most Versatile Weapon in Pandemic |
Favier, V, Daniel, et al |
Frontiers in Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Fenollar, F, Bouam, et al |
J Clin Microbiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7383130; Spontaneous neumomediastin in coronavirus-associated pneumonitis |
Fernández-Raga, S, Fidalgo-Navarro, et al |
Med Clin (Barc) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Abrupt Deterioration of COVID-19 Patients and Spreading of SARS COV-2 Virions in the Lungs |
Filipovic, N, Saveljic, et al |
Ann Biomed Eng |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Fleury, V |
Am J Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Foertter, F, Gaither, et al |
Computing in Science and Engineering |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 Lethality in Sub-Saharan Africa and Helminth Immune Modulation |
Fonte, L, Acosta, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Francescato, D |
Community Psychology in Global Perspective. |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Untangling between fake-news and truth in social media to understand the Covid-19 Coronavirus |
Furini, M, Mirri, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gallagher, K, Ocampo, et al |
Economists' Voice |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Gao, J, He, et al |
Kexue Tongbao/Chinese Science Bulletin |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Giacobbe, F, Bempoorad, et al |
Chemical Engineering Transactions |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Giarelis, N, Kanakaris, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Gilbar, R, Karako-Eyal, et al |
Medical Law International |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33091294; A New Road Map for Our Nation's Response to COVID-19 |
Golden, RN, Kerschner, et al |
WMJ : official publication of the State Medical Society of Wisconsin |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19, multisystem inflammatory syndrome in children, apoE4, and race |
Goldstein, MR, Poland, et al |
J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Emotional Resilience and Bariatric Surgical Teams: a Priority in the Pandemic |
Graham, Y, Mahawar, et al |
Obes Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19 as a modern determinant of oil demand: Pharmaceutical perspective |
Grigorievna, BT, Alekseevna, et al |
Systematic Reviews in Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Risk assessment on continued public health threats: Evidence from China’s stock market |
Gu, J |
International Journal of Environmental Research and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19, Uncertainty, and the Need for Resilience-Based Thinking in Pavement Engineering |
Gulzar, S, Richard Kim, et al |
Journal of Transportation Engineering Part B: Pavements |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Strategic Patenting by Pharmaceutical Companies – Should Competition Law Intervene? |
Gurgula, O |
IIC International Review of Intellectual Property and Competition Law |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gusmano, MK, Sparer, et al |
Health Econ Policy Law |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 impacts on metal supply: How does 2020 differ from previous supply chain disruptions? |
Habib, K, Sprecher, et al |
Resources, Conservation and Recycling |
Commentary/Editorial| Commentaire/Éditorial |
|
|
APOBEC3B and ACE1 indel polymorphisms as prima facie candidates for protection from COVID-19 |
Habib, S, Mukerji, et al |
Current science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Häfner, SJ |
Biomedical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Handfield, R, Finkenstadt, et al |
Milbank Q |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Forward Triage in the COVID-19 Era: The Plastic Surgery Experience |
Haran, O, Brin, et al |
Plast Reconstr Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 and its implications on patient selection for TAVI and SAVR: Are we heading into a new era? |
Harky, A, Seyedzenouzi, et al |
J Card Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hawkes, C |
Global Sustainability |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7577182; Virtual teaching of preventive cardiology: A student experience |
Hays, S, Mankala, et al |
Am J Prev Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Immunesenescence: A Predisposing Risk Factor for the Development of COVID-19? |
Hazeldine, J, Lord, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7177060; [Noninvasive mechanical ventilation and COVID-19. Minimizing dispersion] |
Hernández Garcés, H, Belenguer Muncharaz, et al |
Med Intensiva |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7174162; The challenge of an intensive care unit in a fairground |
Hernández-Tejedor, A, Munayco Sánchez, et al |
Med Intensiva |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hirata, N, Yamakage, et al |
J Anesth |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ho, J |
Japan Forum |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Clinical Reasoning: Therapeutic considerations in myasthenic crisis due to COVID-19 infection |
Hoang, P, Hurtubise, et al |
Neurology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hoang, X, Shaw, et al |
Journal of Global Antimicrobial Resistance |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The COVID-19 Pandemic: Crisis Management for Plastic Surgeons |
Hollier, LH, J, et al |
Plast Reconstr Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Holmes, M |
N C Med J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hsu, Kerry, MH |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Novel coronavirus disease
(Covid-19) jīngfāng prevention and treatment recommendations |
Huang, H, Yao, et al |
Journal of Chinese Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Alteration of physical activity during COVID-19 pandemic lockdown in young adults |
Huber, BC, Steffen, et al |
J Transl Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Health and Well-Being in the Early Stages of the Covid-19 Pandemic: Insights from Applied Psychology |
Inauen, J, Zhou, et al |
Appl Psychol Health Well Being |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 and Children: The Mental & Physical Reverberations of the Pandemic |
Iqbal, SA, Tayyab, et al |
Child Care Health Dev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Jaffe, AM |
Economics of Energy and Environmental Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Jain, V, Al Rifai, et al |
Diabetes care |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Jiang, B, Liang, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33090435; Oxygen therapy strategies and techniques to treat hypoxia in COVID-19 patients |
Jiang, B, Wei, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
What can a plastic surgeon offer during the COVID-19 (coronavirus disease 2019) pandemic? |
Joethy, J, Heng, et al |
Plastic and Reconstructive Surgery - Global Open |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Online Mathematics Tutoring During the COVID-19 Pandemic: Recommendations for Best Practices |
Johns, C, Mills, et al |
PRIMUS |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A potential link between RAAS, obesity and atrial fibrillation in COVID-19 infection |
Jolobe, OMP |
J Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Emerging Challenges and Opportunities for Home Health Care in the Time of COVID-19 |
Jones, CD, Bowles, et al |
J Am Med Dir Assoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Jones, CM, Radhakrishna, et al |
Br J Cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A community-based intervention to mitigate the spread of the COVID-19 pandemic |
Jordan-Martin, N, Madad, et al |
Health Security |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Letter to the editor-COVID-19 and smoking an association requiring urgent attention |
Kalidoss, VK, Bakshi, et al |
Journal of Smoking Cessation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kandhari, R, Kohli, et al |
Dermatologic Therapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kankaew, K, Pongsapak, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Karahan, S, Cetinkaya, et al |
Annals of the Rheumatic Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kavithaa, K, Paulpandi, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Transport industry in the context of the growth of sectors of the Russian economy |
Kazak, AN, Oleinikov, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Macroeconomic aspects of the development of the transport industry under the influence of COVID-19 |
Kazak, AN, Oleinikov, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
33081456; Features of neurological manifestations of the COVID-19 in children and adults |
Kholin, AA, Zavadenko, et al |
Zhurnal nevrologii i psikhiatrii imeni S.S.Korsakova |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: "There is no alternative," says Johnson, announcing new restrictions for England |
Kmietowicz, Z |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Komoliatova, VN, Makarov, et al |
Kardiologiya |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Addiction as a Coping Response: Hyperkatifeia, Deaths of Despair, and COVID-19 |
Koob, GF, Powell, et al |
Am J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kurbakova, S, Volkova, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33081458; Clinical and pathogenetic aspects of nervous system impairments in COVID-19 |
Kutlubaev, MA |
Zhurnal nevrologii i psikhiatrii imeni S.S.Korsakova |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kuzuya, M, Aita, et al |
Geriatr Gerontol Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The role of Remote Working in smart cities: lessons learnt from COVID-19 pandemic |
Kylili, A, Afxentiou, et al |
Energy Sources, Part A: Recovery, Utilization and Environmental Effects |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lanièce Delaunay, C, Saeed, et al |
J Am Med Dir Assoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lanziotti, VS, de Souza, et al |
Pediatr Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
How the ecology and evolution of the COVID-19 pandemic changed learning |
Lashley, MA, Acevedo, et al |
Ecology and Evolution |
Commentary/Editorial| Commentaire/Éditorial |
|
|
33082543; How obesity could create problems for a COVID vaccine |
Ledford, H |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7578702; Agile clinical research: A data science approach to scrumban in clinical medicine |
Lei, H, O'Connell, et al |
Intell Based Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lema, GF |
Revista Chilena de Anestesia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The potential of electrochemistry for the detection of coronavirus-induced infections |
Lim, RRX, Bonanni, et al |
TrAC - Trends in Analytical Chemistry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
IoTtalk experience on building commercial IoT/AI applications |
Lin, YB, Yen, et al |
International Journal of Sensor Networks |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Change gradually, then all at once: the general election of February 2020 in the Republic of
Ireland |
Little, C |
West European Politics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Liu, Q, He, et al |
Frontiers in Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Liu, W, Guan, et al |
Engineering |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
China's logistics development trends in the post COVID-19 era |
Liu, W, Liang, et al |
International Journal of Logistics Research and Applications |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Protecting Healthcare Workers Amid the COVID-19 Crisis: A Safety Protocol in Wuhan |
Liu, Y, Yang, et al |
Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Approach to assessment of new swabs and viral transport media for SARS-CoV-2 testing |
Locher, K, Velapatino, et al |
J Clin Microbiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lubkov, AV, Gordienko, et al |
Education and Self Development |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Anti-COVID-19 drug screening: Frontier concepts and core technologies |
Luo, H, Zhao, et al |
Chinese Medicine (United Kingdom) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lynch, HF, Bateman-House, et al |
Ann Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Navigating urology’s new normal and mitigating the effects of a second wave of COVID-19 |
MacDonald, L, Cox, et al |
Canadian Urological Association Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
MacDonald, S, Kovacs, et al |
CJEM |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Machado, AS, Pereira, et al |
J Occup Environ Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19: Experts question evidence behind prime minister's promise of rapid tests |
Mahase, E |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Plastics and the coronavirus pandemic: a behavioral science perspective |
Makki, F, Lamb, et al |
Mind and Society |
Commentary/Editorial| Commentaire/Éditorial |
|
|
What influences sentiment analysis on social networks: A case study |
Mambelli, G, Prandi, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
A Study of Security Threats in Cloud: Passive Impact of COVID-19 Pandemic |
Mandal, S, Khan, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Manych, M |
Pneumologie |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Marks, P |
Communications of the ACM |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Marmolejo, L, Barberi, et al |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Matsuoka, R, Masuda, et al |
Asaio j |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Recomendaciones para la cirugía electiva pediátrica segura durante la pandemia
COVID-19 |
Maureira, V, Ostermann, et al |
Revista Chilena de Anestesia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Coronavirus Proteins as Ion Channels: Current and Potential Research |
McClenaghan, C, Hanson, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
McIntyre, K |
Nonwovens Industry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 as a trigger for global transport infrastructure digitalization |
Medyakova, EM, Kislitskaya, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Meffre, E, Iwasaki, et al |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33077974; Latin America's embrace of an unproven COVID treatment is hindering drug trials |
Mega, ER |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The COVID-19 pandemic intensified resource conflicts and indigenous resistance in Brazil |
Menton, M, Milanez, et al |
World Development |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mertz, L |
IEEE Pulse |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Meyer, T, Posthumus, et al |
Die Rehabilitation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Michie, S, West, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Modernization of mechatronic smart windows system to counteract the spread of COVID-19 |
Mikhailov, L, Mikhailova, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Vulnerability of the medical product supply chain: the wake-up call of COVID-19 |
Miller, FA, Young, et al |
BMJ Qual Saf |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lessons learned from the CoviD-19 pandemic and their possible consequences on manufacturing |
Monostori, L, Váncza, et al |
Smart and Sustainable Manufacturing Systems |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mossad, SB |
Cleve Clin J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mundt, AP |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Muniangi-Muhitu, H, Akalestou, et al |
Frontiers in Endocrinology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Healthcare utilization patterns among persons who use drugs during the COVID-19 pandemic |
Murphy, SM, Yoder, et al |
Journal of substance abuse treatment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Murray, LJ, Kras, et al |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Public Libraries as health literate multi-purpose workspaces for improving health literacy |
Naccarella, L, Horwood, et al |
Health Promot J Austr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nadkarni, A, Hasler, et al |
Am J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A commentary on “The coronavirus (COVID-19) pandemic: Adaptations in medical education” |
Naglik, L, Ravindran, et al |
International Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nakamura-Pereira, M, Libertad Soligo Takemoto, et al |
J Matern Fetal Neonatal Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Navigating Patient Care, Teleaudiology during the COVID-19 Pandemic |
Nalley, C |
Hearing Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nash, DB |
Population health management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nasr, S, Hidouri, et al |
ECS Journal of Solid State Science and Technology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nazarious, MI, Mathanlal, et al |
HardwareX |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Neki, NS |
International Journal of Current Research and Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
ERPP special section editorial perspectives: COVID-19 and educational change |
Ng, PT |
Educational Research for Policy and Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Perspective of comprehensive and comprehensible multi-model energy and climate science in Europe |
Nikas, A, Gambhir, et al |
Energy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Niriella, MA, Siriwardana, et al |
Transplant Proc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The pivotal role of the angiotensin-II-NF-κB axis in the development of COVID-19 pathophysiology |
Okamoto, H, Ichikawa, et al |
Hypertens Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Words as powerful weapons: Dysphemism in Trump's Covid-19 speeches |
Olimat, SN |
3L: Language, Linguistics, Literature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Modeling a Pandemic (COVID-19) Management Strategy for Urban Slums Using Social Geometry Framework |
Onditi, F, Obimbo, et al |
European Journal of Development Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
33079194; Building Trust to Achieve Confidence in COVID-19 Vaccines |
Opel, DJ, Salmon, et al |
JAMA network open |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Replication and extension of framing effects to compliance with health behaviors during pandemics |
Otterbring, T, Festila, et al |
Safety Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pálsdóttir, D |
Laeknabladid |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pan, Y, Han, et al |
Zhonghua wei zhong bing ji jiu yi xue |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Emergency Department Psychiatric Observation Units: Good Care and Good Money? |
Parwani, V, Goldenberg, et al |
Acad Emerg Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Patel, VK, Ye, et al |
J Gastrointest Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32436481; Hazard control for communicable disease transport at Ornge |
Peddle, MB, Smith, et al |
CJEM |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7485491; Intrauterine vertical transmissibility of SARS-CoV-2: the evidence is evolving |
Penfield, CA, Lighter, et al |
Am J Obstet Gynecol MFM |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pesqueux, Y |
Innovar |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Assessing racial inequality in COVID-19 testing with Bayesian threshold tests |
Pierson, Emma |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Porfidia, A, Santoliquido, et al |
Journal of Thrombosis and Haemostasis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pyone, T, Aung, et al |
BMJ Glob Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Residency Leadership Lessons From the Epicenter of the COVID-19 Surge |
Rabin, E, Willis, et al |
AEM Education and Training |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Strategies for General Surgery Training Programs During the COVID-19 Pandemic |
Ragauskas, AME, Scott, et al |
Am Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Preventing the re-establishment of malaria in Sri Lanka amidst the COVID-19 pandemic |
Ranaweera, P, Wickremasinghe, et al |
Malar J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
An Examination of COVID-19 Outbreaks in South American Prisons and Jails |
Rapisarda, SS, Byrne, et al |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Commentary on “Near-peer OSCE-style joint examination videos improve confidence in the clinical environment” |
Ravindran, P, Naglik, et al |
International Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Razavi, S, Behrendt, et al |
International Social Security Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Redondo, S, Gonçalves, et al |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ren, L, Li, et al |
Infection, Genetics and Evolution |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Resler, K, Fraczek, et al |
Hearing Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Revzin, MV, Raza, et al |
Radiographics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ribeiro, IRS, da Silva, et al |
Nano Today |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Richter, A, Plant, et al |
Nat Microbiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Riemann, JF |
MMW Fortschr Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7454272; Risch Responds to "How to Consider Low Reported Death Rates in COVID-19" |
Risch, HA |
Am J Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ritchie, MK, Fox, et al |
Asaio j |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33091279; Redefining Self-Interest - The US Response to COVID-19 |
Roddy, JJ, Muehlbauer, et al |
WMJ : official publication of the State Medical Society of Wisconsin |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rodríguez, CJF |
Innovar |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Is remote the new normal? Reflections on Covid-19, technology, and humankind |
Rogers, Y |
Interactions |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rostami Mansoor, S, Ghasemi-Kasman, et al |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ruiz de Pellón Santamaría, Á |
J Clin Psychopharmacol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Expanding global and national influenza vaccine systems to match the COVID-19 pandemic response |
Ruscio, BA, Hotez, et al |
Vaccine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ryabykina, GV |
Kardiologiya |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Saad, NH, AlQattan, et al |
Plast Reconstr Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sachwani-Daswani, G, Atkinson, et al |
Surg Innov |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Risk/caution of vitamin D insufficiency for quarantined athletes returning to play after COVID-19 |
Saita, Y |
BMJ Open Sport and Exercise Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Healthcare capacity building
to facilitate pandemic preparedness |
Sakhi, J, Ubada, et al |
Disaster Advances |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Salsi, G, Seidenari, et al |
Am J Obstet Gynecol MFM |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sandberg, R |
Ecclesiastical Law Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 Pandemic: Its Impact and Collateral Damage in India |
Sane, V, Sane, et al |
J Craniofac Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sangiorgi, L, Brizola, et al |
Ir J Med Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sustainability perceptions in tourism and hospitality: A mixed-method bibliometric approach |
Santos, LL, Cardoso, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Enforcing the Right to a Healthy Environment in the Climate
Emergency: A View from Above |
Savaresi, Annalisa |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Status Dynamics of Role Blurring in the Time of COVID-19 |
Schieman, S, Badawy, et al |
Socius |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Schurwanz, Max, Hoeher, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Scott Price, O, Luis, et al |
Limnology and Oceanography Bulletin |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Semiz, S, Serdarevic, et al |
Frontiers in Nutrition |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mental Health Impact of SARS-COV-2 Pandemic on Long-Term Care Facility Personnel in Poland |
Senczyszyn, A, Lion, et al |
J Am Med Dir Assoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A Comparison of COVID-19 Mortality Rates Among Long-Term Care Residents in 12 OECD Countries |
Sepulveda, ER, Stall, et al |
J Am Med Dir Assoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Serezhina, EK, Obrezan, et al |
Kardiologiya |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Paracetamol-Induced Glutathione Consumption: Is There a Link With Severe COVID-19 Illness? |
Sestili, P, Fimognari, et al |
Frontiers in Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Shafi, AMA, Awad, et al |
J Card Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sheridan, L |
Rehabilitation Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Silva, FVD, Souza, et al |
Revista brasileira de enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Simonsen, AB, Ruge, et al |
Br J Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Specialized Pharmacist Roles and Perspectives in the Collaborative Management of COVID-19 |
Skoglund, E, Ayoub, et al |
J Pharm Pract |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Song, J, Liu, et al |
Shanghai kou qiang yi xue = Shanghai journal of stomatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Fragmented restrictions, fractured resonances: grassroots responses to Covid-19 in China |
Song, Y, Liu, et al |
Critical Asian Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Co-infections: testing macrolides for added benefit in patients with COVID-19 |
Sterenczak, Katharina Anna, Barrantes, et al |
The Lancet Microbe |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Straiton, J |
BioTechniques |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33082537; COVID-19 vaccines: time to talk about the uncertainties |
Subbarao, K |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tanne, JH |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 and the Contours of the Impending Global Crisis: Western
Meltdown, European Fallout? |
Tausch, Arno |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tel, A, Stacchi, et al |
J Craniofac Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33091277; Emotional Support in Times of COVID-19: A Latinx Community Initiative |
Tellez-Giron, P, Cano Ospina, et al |
WMJ : official publication of the State Medical Society of Wisconsin |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Learning from New York City health + hospitals' experience with COVID-19 |
Toner, E |
Health Security |
Commentary/Editorial| Commentaire/Éditorial |
|
|
CHOCSLAT: Chinese Healthcare-Oriented Computerised Speech & Language Assessment Tools |
Towey, D, Jin, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Remote Workers During the COVID-19 Lockdown. What Are We Missing and Why Is Important |
Tronco Hernandez, YA |
J Occup Environ Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7435494; The psychological impact of coronavirus outbreak in Pakistan |
Um Min Allah, N, Arshad, et al |
Asia Pac Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
ACUTE ISCHEMIC AND HEMORRHAGIC STROKE IN TWO COVID-19 PATIENTS |
Urciuoli, L, Guerriero, et al |
Jpn J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Valeriani, G, Sarajlic Vukovic, et al |
Healthcare (Basel) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33090451; Access to health care after COVID-19 pandemic: is it time for telemedicine? |
Vanni, G, Materazzo, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
33081457; Pandemic COVID-19 and mental disorders international experience and therapeutic approaches |
Vasileva, AV |
Zhurnal nevrologii i psikhiatrii imeni S.S.Korsakova |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Vimal Kumar, MN, Jaya, et al |
European Journal of Molecular and Clinical Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Voas, J, Laplante, et al |
Computer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mesenchymal stem cells in the treatment of COVID-19- progress and challenges |
Wang, J, Zou, et al |
Shengwu Gongcheng Xuebao/Chinese Journal of Biotechnology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Potential Neurochemical and Neuroendocrine Effects of Social Distancing Amidst the COVID-19 Pandemic |
Wang, L, Nabi, et al |
Frontiers in Endocrinology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hypothesis: What is the best we can do with hydroxychloroquine for COVID-19? |
Wang, S, Mulier, et al |
Clinical Epidemiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wang, Z, Sun, et al |
Journal of Chinese Political Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 and liver transplantation: the jury is still out - Authors' reply |
Webb, GJ, Marjot, et al |
Lancet Gastroenterol Hepatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wei, EK, Segall, et al |
Health Security |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33087228; Juvenile Embolic Stroke Complicating COVID-19 Infection |
Weidauer, S, Tafreshi, et al |
Deutsches Arzteblatt international |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Weiss, SL, Peters, et al |
Pediatr Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Wescott, S, Mittelstet, et al |
AMA Journal of Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33087230; Inhalation and Ingestion of Disinfectant as a Mimic of COVID-19 Infection |
Willems, LM, Samp, et al |
Deutsches Arzteblatt international |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: T cell response lasts for at least six months after infection, study shows |
Wise, J |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Empowering the workforce in post–covid-19 smart manufacturing systems |
Wuest, T, Romero, et al |
Smart and Sustainable Manufacturing Systems |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Yadav, R, Bansal, et al |
Indian heart journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yao, M, Chen, et al |
Zhonghua wei zhong bing ji jiu yi xue |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Acupuncture
strategies to tackle post covid-19 psychological and neuropsychiatric disorders |
Ye, L, Sun, et al |
Journal of Chinese Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Yokoo, P, Silva, et al |
Einstein (Sao Paulo, Brazil) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Excess all-cause mortality during the COVID-19 outbreak in Japan |
Yorifuji, T, Matsumoto, et al |
J Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Working upstream in advance care planning in pandemic palliative care |
Zaurova, M, Krouss, et al |
Health Security |
Commentary/Editorial| Commentaire/Éditorial |
|
|
How Webinars Have Lit Residents' Interest in Aesthetic Surgery during COVID-19 |
Zena, M, Paternostro, et al |
Plast Reconstr Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Fast response to superspreading: Uncertainty and complexity in the context of COVID-19 |
Zenk, L, Steiner, et al |
International Journal of Environmental Research and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zhang, P, Salafia, et al |
Am J Obstet Gynecol MFM |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zhu, L, Wang, et al |
Shanghai kou qiang yi xue = Shanghai journal of stomatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Economic Outlook |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33087926; 'Uncrushable' beetle and COVID's lack of seasonality |
|
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pediatric dentistry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
9th International Conference
on Health Information Science, HIS 2020 |
|
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
World sugar market: Oil price crush and Covid-19 weigh on world market sugar prices |
|
Zuckerindustrie |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Revista de Derecho Civil |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID research updates: How 45 countries rank on coronavirus infections |
|
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
J Occup Environ Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
2020 IEEE
Symposium on Computers and Communications, ISCC 2020 |
|
|
Commentary/Editorial| Commentaire/Éditorial |
|
Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.*
Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.
Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers.
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Séquelles à long terme:
Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.
Santé mentale:
Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées
à la pandémie.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives