Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-11-03
Good afternoon,
There are 850 citations in today’s scan. 418 were considered primary research or review literature.
Highlights today include:
PUBLIC HEALTH INTERVENTION
·
Wehenkel
analyzed the association between COVID-19 related deaths and influenza vaccination rate (IVR) in elderly people worldwide. The results showed a positive association between COVID-19 deaths and IVR of people ≥65 years-old.
TRANSMISSION
·
Khanh et al., investigated a cluster of cases among passengers on a 10-hour commercial flight. Among the 16 persons in whom SARS-CoV-2 infection was detected,
12 (75%) were passengers seated in business class along with the only symptomatic person (attack rate 62%). Seating proximity was strongly associated with increased infection risk.
·
Pringle et al
presents a confirmed case of coronavirus disease 2019 (COVID-19) in a male correctional facility employee aged 20 years who had multiple brief exposures to six IDPs who later tested positive for SARS-CoV-2; available data suggests that at least one of
the asymptomatic IDPs transmitted SARS-CoV-2 during these brief encounters.
·
Harvey et al.
conducted longitudinal swab sampling of high-touch surfaces in a Massachusetts town during a COVID-19 outbreak from April to June 2020. Twenty-nine of 348 (8.3 %) surface samples were positive for SARS-CoV-2, including crosswalk buttons, trash can handles,
and door handles of essential business entrances (grocery store, liquor store, bank, and gas station). The estimated risk of infection from touching a contaminated surface was low (less than 5 in 10,000), suggesting fomites play a minimal role in SARS-CoV-2
community transmission
SURVEILLANCE
·
Jafferali et al
compare different virus concentration methods in municipal wastewater for subsequent qPCR detection of viral RNA. A modified ultrafiltration method is found to be the most sensitive for qPCR detection of SARS-CoV-2 in wastewater.
EPIDEMIOLOGY
·
Du et al
present genomic surveillance data on 102 imported cases, which account for 17.2% of the total cases in Beijing. Genomic comparisons reveal higher genomic diversity in the imported group compared to both the Wuhan exposure and local transmission groups,
indicating continuous genomic evolution during global transmission. Epidemiological data suggest that detection of cases at immigration with mandatory quarantine may be an effective way to prevent recurring outbreaks triggered by imported cases.
·
Pan et al
identified the risk factors associated with prolonged shedding in patients with coronavirus disease 2019 (COVID-19), and evaluated the effects of current clinical and clinicopathological factors on viral shedding in patients. The median duration of viral
shedding was 12 days in non-severe patients, and 17 days in severe patients. Multi-factor regression analysis suggested that the onset-hospitalization interval odds ratio, and comorbidity with a chronic disease were independent risk factors for prolonged viral
shedding, whereas lopinavir/ritonavir (LPV/r) was an independent protective factor.
·
Lan et al
investigate SARS-CoV-2 (the virus causing COVID-19) infection and exposure risks among grocery retail workers, and to investigate their mental health state during the pandemic. In this single store sample, we found a considerable asymptomatic SARS-CoV-2
infection rate among grocery workers. Employees with direct customer exposure were five times more likely to test positive.
·
Bedford et al
applied genomic epidemiology to investigate the origins of an outbreak of 50
COVID-19 cases of individuals employed at or visiting the White House.
LONG TERM SEQUELAE
·
Rogliani et al
provide preliminary evidence that hospitalized patients with mild-to-moderate forms of COVID-19 are not at risk of developing pulmonary fibrotic sequelae.
·
Gamba and Zaniboni
evaluate whether COVID-19 positive patients with olfactory and gustatory dysfunction (n=73) have the ability to recover from chemoreceptorial loss. Based on scores of the Olfactory Dysfunction Questionnaire CoViD-19 (QOD), total recovery in all patients
of olfactory and gustatory function was recorded with an average time of 17.4 days.
VACCINE RESEARCH
·
Mazumder et al
developed PRAK−03202, the world′s first triple antigen VLP vaccine candidate, which induced SARS CoV−2 specific neutralizing antibodies in BALB/c mice. Immunizations using three different doses of PRAK−03202 induces antigen specific (Spike, envelope
and membrane proteins) humoral response and neutralizing potential. PBMCs from convalescent patients, when exposed to PRAK−03202, showed lymphocyte proliferation and elevated IFN-γ levels suggestive of conservation of epitopes and induction of T helper 1 (Th1)−biased
cellular immune responses.
PUBLIC HEALTH RESPONSE
·
Trudeau et al., distributed a web-based survey in 16 Latin American countries to evaluate regional attitudes towards the emerging COVID-19
outbreak and willingness to pay (WTP) for COVID-19 testing. They observe that the cost of the test and household income are important determinants of testing intentions. They find higher WTP among those reporting greater concern relative to the average respondent.
·
Olagoke et al.,
examine the role of health locus of control (HLOC) in the relationship between religiosity and COVID-19 vaccination intention. They found significantly negative association between religiosity
and COVID-19 vaccination intention. This relationship was partially mediated by external HLOC.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura
Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox, Joanne Hiebert
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Long-term Sequelae, Mental Health, Surveillance, Coronavirology, Diagnostics /
Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, Immunology, Economics, Animal model, Zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Séquelles à long terme, Santé mentale ,Surveillance,
Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, Immunologie,
économie, Modèle animal, Zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
|
PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
32986671; Managing Clinical Trials for Alzheimer's Disease during the COVID-19 Crisis: Experience at Fundació ACE in Barcelona, Spain |
Abdelnour, C, Esteban De Antonio, et al |
Journal of Alzheimer's Disease |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study aimed to describe the ad-hoc strategic plan developed to cope with this crisis and to share its outcomes.
A total of 130 patients were participating in 16 active clinical trials in Fundació ACE when the lockdown was established. During the confinement, we performed 1018 calls to the participants, which led to identify adverse events in 26 and COVID-19 symptoms
in 6. A total of 83 patients (64%) could restart on-site visits as early as May 11, 2020. All SARS-CoV-2 RT-PCR diagnostic tests performed before on-site visits were negative and only three IgG serological tests were positive. Throughout the study period,
we only observed one drop-out, due to an adverse event unrelated to COVID-19. |
|
Clinical characteristics and in-hospital mortality of COVID-19 adult patients in
Saudi Arabia |
Abohamr, SI, Abazid, et al |
Saudi Med J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this record-based case-series study conducted in Saudi Arabia was to provide a detailed study of demographic, baseline comorbidities,
clinical features, and outcome for COVID-19 patients. A total of 768 patients were included. Approximately 96.3% reported more than one comorbidity; diabetes mellitus was the most frequent (46.4%). Approximately 45.8% of enrolled patients required intensive
care unit admission. Patients who were obese and smokers with history of diabetes mellitus had a high risk of death. |
|
Abualfadl, E, Ismail, et al |
Rheumatol Int |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this work was to study the impact of the pandemic on rheumatoid arthritis (RA) patients through a patient-reported questionnaire. The questionnaire
provided covered socio-demographic data, health/disease status, information/knowledge about COVID-19 and medical/family history of the infection. The present questionnaire revealed that 9.4% contracted suspected COVID-19 infection. Urban patients were more
likely to be infected by COVID-19 than rural. Significant risk factors that influence or predict suspected COVID-19 included age, being from upper Egypt, urban residency, intake of leflunomide, receiving biologics, irregular intake of medications, presence
of renal and chest co-morbidities and travelling over the last 60 days |
|
|
Achdout, Hagit, Aimon, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This report providea a living summary of the data generated during the COVID Moonshot project focused on the development of SARS-CoV-2 main protease (Mpro)
inhibitors. This manuscript describes methodologies leading to both covalent and non-covalent inhibitors displaying protease IC50 values under 150 nM and viral inhibition under 5 uM in multiple different viral replication assays. Also provide over 200 crystal
structures of fragment-like and lead-like molecules in complex with the main protease. Over 1000 synthesized and ordered compounds are also reported with the corresponding activity in Mpro enzymatic assays using two different experimental setups. |
|
|
Acute pancreatitis in a COVID-19 patient: An unusual presentation |
Acherjya, GK, Rahman, et al |
Clinical Case Reports |
Clinical data| Données cliniques |
W present a confirmed case of COVID‐19 who developed acute pancreatitis during acute disease phase without any other obvious discernible cause of it. |
|
The impact of covid on network utilization: An analysis on domain popularity |
Affinito, A, Botta, et al |
|
Public Health response| Interventions de santé publique |
In this paper, we provide insights on the use of different categories of Internet applications. Our results show that,
during lockdowm time, the most used applications have been Youtube followed by Netflix, Facebook, Whatsapp and Skype. |
|
Agberotimi, SF, Akinsola, et al |
Frontiers in Psychology |
Mental Health | |
This study examines the mental health outcomes among the healthcare personnel and the general population and the role
of socioeconomic status. The study concluded that the prevalence of poor mental health outcomes during the COVID-19 crisis among Nigerians is worrisome. |
|
|
Agbing, LU, Agapito, et al |
Illness Crisis and Loss |
Mental Health |
|
The objective of this study was to explore thoughts and feelings of children on COVID-19, find out how they cope, and
what they did during lockdown. Author recommendations are to develop strategies to assist children during critical events; studies – find out effects of pandemic on participants’ health; visit participants after two years to find out reminiscence of pandemic
experience. |
|
|
“Fei Yan No. 1” as a Combined Treatment for
COVID-19: An Efficacy and Potential Mechanistic Study |
Ai, Z, Zhou, et al |
Frontiers in Pharmacology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
A retrospective study of 84 COVID-19 patients from Hubei Provincial Hospital of TCM and Renmin Hospital of Hanchuan
was conducted to explore the clinical efficacy of QFDYG combination therapy. After 14 days of treatment, QFDYG combined treatment increased the proportion of patients testing negative for SARS-CoV-2 nucleic acid by RT-PCR. Compared with the control group,
promoting focal absorption and inflammation as viewed on CT images. The present study revealed that QFDYG combination therapy offered particular therapeutic advantages, indicating that the theoretical basis for the treatment of COVID-19 by QFDYG may play
an antiviral and immune response regulation through multiple components, targets, and pathways, providing reference for the clinical treatment of COVID-19. |
|
Akter, F, Mannan, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study investigated the clinical manifestations, outcomes and long-term complications of COVID-19 inpatients in
southern part of Bangladesh while emphasizing on individuals having diabetes. There were 734 COVID-19 presentations in this study of which 19.8% of patients had diabetes and 76% of the COVID-19 patients were male. Among biochemical parameters, plasma glucose,
D-dimer, and Troponin-I levels were significantly elevated amidst the cohort with diabetes. The frequency of patients requiring insulin increased threefold during infection with SARS CoV-2. 1.4% patients developed new onset of diabetes mellitus. A number of
COVID-19 patients with diabetes have been suffering from complications post-recovery including pain, discomfort, and sleep disturbance. |
|
|
Alcaide Lucena, M, Martínez Martínez, et al |
Revista de Senologia y Patologia Mamaria |
Healthcare Response | Réponse des soins de santé |
We analysed and compared the data from the breast unit of a second-level hospital in terms of the activity of the Early
Breast Cancer Detection Programme (EBCDP), the cancer diagnoses made, and the patients undergoing surgery from March to May, 2020, compared with the same period in the previous year. The number of patients attended in the EBCDP in March and May decreased
by 91.7% and those attended in the Radiodiagnostics Service of the hospital fell by 54.2%. Surgical activity also decreased by 57.69% compared with the same period in 2019. |
|
|
Anakinra as rescue therapy to treat patients with severe COVID-19 refractory
to tocilizumab |
Alijotas-Reig, Jaume |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
SRAS-CoV-2 patients were primarily managed with non-invasive ventilation outside of the ICU and received standard of
care with hydroxychloroquine, lopinavir/ritonavir, azithromycin, and enoxaparin supplemented with tocilizumab; an additional administration of 100 mg subcutaneous anakinra twice a day (low-dose) or every 6-8 hours (medium-dose). In severe ARDS related to SARS-CoV-2
refractory to standard of care plus tocilizumab, low-to-moderate doses of anakinra as a rescue therapy showed effectiveness and safety, avoiding mechanical ventilation and deaths. |
|
Alison Holman, E, Thompson, et al |
Science Advances |
Mental Health |
|
Between 18 March and 18 April 2020, as illness and death escalated in the United States, we assessed acute stress,
depressive symptoms, and direct, community, and media-based exposures to COVID-19 in three consecutive representative samples from the U.S. probability-based nationally representative NORC AmeriSpeak panel across three 10-day periods. Acute stress and depressive
symptoms increased significantly over time as COVID-19 deaths increased across the United States. Preexisting mental and physical health diagnoses, daily COVID-19–related media exposure, conflicting COVID-19 information in media, and secondary stressors were
all associated with acute stress and depressive symptoms. |
|
|
Targeting the GRP78-Dependant SARS-CoV-2 Cell Entry by Peptides and Small Molecules |
Allam, L, Ghrifi, et al |
Bioinformatics and Biology Insights |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study reports potential inhibitors comprising small molecules and peptides that could interfere with the interaction
of SARS-CoV-2 and its target cells by blocking the recognition of the GRP78 cellular receptor by the viral Spike protein. These inhibitors were discovered through an approach of in silico screening of available databases of bioactive peptides and polyphenolic
compounds and the analysis of their docking modes. This process led to the selection of 9 compounds with optimal binding affinities to the target sites. The peptides (satpdb18674, satpdb18446, satpdb12488, satpdb14438, and satpdb28899) act on regions III and
IV of the viral Spike protein and on its binding sites in GRP78. However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the
ATPase domain of GRP78. |
|
COVID-19 knowledge and perception among healthcare professionals
in two Arabian Gulf countries |
Alsaleh, NA, Alshammari, et al |
International Journal of Pharmaceutical Research |
Healthcare Response | Réponse des soins de santé |
The objective of this study is to investigate healthcare professional's knowledge and awareness about COVID-19 among
healthcare workers in Saudi Arabia and Kuwait. A total of 460 healthcare professionals completed the questionnaire, 37.8%(n=174) were males. The age of the participants ranged from 18 to 64 and 80.4% (n=370) of the participants were aged 34 or below. Official
government websites 54.8% (n=252) and social media 43.3% (n=199) were the major reliable information sources related to COVID-19. only 37% (n=170) mentioned that the coronavirus disease could transmit through contact. In addition, only 42% (n=191) of the study
participants had the correct knowledge about the incubation period of the disease. Moreover, 43.5% (n=200) of the participants were able to identify the symptoms of COVID-19. Conclusion: The study recommended the need to focus more on educational and awareness
programs targeting all healthcare professionals to ensure the best practice and provide the optimal care. |
|
Alshami, A, Alattas, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we aimed to study the clinical presentations, and viral clearance of SARS-COV-2 positive quarantined
individuals. The prevalence of asymptomatic carriers among quarantined travelers and those identified by contact tracing is high in our study. Therefore, testing, tracing, and isolating travelers and contacts of laboratory-confirmed cases, regardless of symptoms,
were very effective measures for early disease identification and containment. Loss of taste and smell were the most common presentations in our mild symptomatic residents. The persistent positive PCR beyond 14 days observed in the mild symptomatic residents
despite being symptoms free, warrant further studies to determine its implications on disease spread and control. |
|
|
Alzueta, E, Perrin, et al |
J Clin Psychol |
Mental Health |
|
This study examined the impact of the COVID‐19 pandemic and subsequent social restrictions or quarantines on the mental
health of the global adult population. In order to asses mental health a sample of 6,882 individuals (Mage = 42.30; 78.8% female) from 59 countries completed an online survey asking about several pandemic‐related changes in life and psychological status. Of
these participants, 25.4% and 19.5% reported moderate‐to‐severe depression (DASS‐21) and anxiety symptoms (GAD‐7), respectively. Demographic characteristics (e.g. higher‐income country), COVID‐19 exposure (e.g., having had unconfirmed COVID‐19 symptoms), government‐imposed
quarantine level, and COVID‐19‐based life changes (e.g., having a hard time transitioning to working from home; increase in verbal arguments or conflict with other adult in home) explained 17.9% of the variance in depression and 21.5% in anxiety symptoms. |
|
|
Generalized growth curve model for COVID-19 in Brazilian states |
Amaral, MTR, Conceição, et al |
Revista Brasileira de Biometria |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The present paper consists of using the Chapman-Richard generalized growth model to functionally relate the number
of people infected by COVID-19 with the number of days. The methodology used allowed consistent estimates of the number of people infected by COVID-19 as a function of time and, consequently, it was possible to conclude that the projections provided by the
growth curves point to a scenario of general contamination acceleration. Besides, the models predict that the epidemic is close to reaching its peak in Amazonas, Ceará, Maranhão, Pernambuco, and São Paulo States of Brazil. |
|
Anand, R, Biswal, et al |
PeerJ |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
In this study, validated computational approaches were used to identify peptide-based epitopes from six structural
proteins having antigenic properties. Taken together, eleven T cell epitopes, seven B cell linear epitopes and ten B cell conformational epitopes were identified from five structural proteins of SARS-CoV-2 using advanced computational tools. These potential
vaccine candidates may provide important timely directives for an effective vaccine. |
|
|
Modified Machine Learning Techique for Curve Fitting on Regression Models
for COVID-19 projections |
Andreas, A, Mavromoustakis, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We propose the development of an improved mathematical forecasting framework based on machine learning and the cloud
computing system with data from a real-time cloud data repository. Our goal is to predict the progress of the curve as accurately as possible in order to understand the spread of the virus from an early stage so that strategies and policies can be implemented. |
|
Andring, JacobT, McKenna, et al |
bioRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
This study explored the underlying COVID-19 mechanisms engaged by these extra-pulmonary organ systems (gastrointestinal,
renal, and cardiac muscle). The present study employed molecular docking modeling to examine the interplaying assemblage of ACE2, ADAM17 and B0AT1. And report that in the monomer form of ACE2, neck region residues R652-N718 provide unimpeded access to ADAM17
active site pocket, but notably R708 and S709 remained >10-15 Å distant. In contrast, interference of ADAM17 docking to ACE2 in a dimer-of-heterodimers arrangement was directly correlated with the presence of a neighboring B0AT1 subunit complexed to the partnering
ACE2 subunit of the 2ACE2:2B0AT1 dimer of heterodimers, representing the expression pattern putatively exclusive to intestinal, renal and cardiomyocyte cell types. The monomer and dimer-of-heterodimers docking models were not influenced by the presence of
SARS-CoV-2 receptor binding domain (RBD) complexed to ACE2 |
|
|
Can the damage be undone? analyzing misinformation during COVID-19 outbreak
in Indonesia |
Angeline, M, Safitri, et al |
|
Public Health response| Interventions de santé publique |
This study aims to give recommendations for dealing with misinformation in Indonesia. this paper recommends reducing
the number of misinformation through three perspectives - identification of misinformation, platforms, and support for targeted people. |
|
Behavioral changes and hygiene practices of older adults in Japan during
the COVID-19 emergency |
Arai, Yasumichi, Oguma, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
Study was to explore the behavioral changes and personal hygiene practices of older adults during the COVID-19 emergency.
94.5% of the respondents reported no changes in basic lifestyle habits, such as eating, sleeping, smoking, and drinking, whereas 28.1% reported a decrease in the amount of physical activity, and 54.6% reported going out less frequently. One third of the respondents
reported a decrease in the number of people to converse with, as well as the amount of time to converse. For personal hygiene practices, 93.8% reported wearing a mask when they went out, and 50.3% reported a more frequent washing of hands. |
|
Arvelo, E, de Armas, et al |
International Journal of Environmental Research and Public Health |
Epidemiology| Épidémiologie |
In this work, we establish a methodological framework to analyze the care demand for elderly citizens in any area with
a large proportion of elderly population, and to find connections to the cumulative incidence of COVID-19. We applied this methodology to Barcelona to analyze the distribution of the demand for elderly care services. Considering the characteristics that were
likely to impact the demand for homecare in the neighborhoods, we clearly identified five groups of neighborhoods with different profiles and needs. Additionally, we found that the number of cases in each neighborhood was more correlated to the number of elderly
people in the neighborhood than it was to the number of beds in assisted living or day care facilities in the neighborhood, despite the negative impact of COVID-19 cases on the reputation of this kind of center. |
|
|
33077980; Care path for non-deferred elective hospitalizations in cardiology in the Covid-19
period |
Astegiano, V, Condò, et al |
Assistenza Infermieristica e Ricerca : AIR |
Healthcare Response | Réponse des soins de santé |
This study aimed to describe the organizational model adopted for elective procedures during the Covid-19 pandemic,
to guarantee maximum safety for patients and healthcare workers. A total of 66 patients were contacted and 40 accepted the hospital admission (26 refused it, for fear of infection or covid-19 related family problems). No patient resulted positive to the nasal
swab. |
|
Attallah, O, Ragab, et al |
PeerJ |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this article, a novel computer-aided diagnosis (CAD) system is proposed for diagnosing COVID-19 based on the fusion
of multiple convolutional neural networks (CNNs). The results show that the proposed system is effective and capable of detecting COVID-19 and distinguishing it from non-COVID-19 cases with an accuracy of 94.7%, AUC of 0.98 (98%), sensitivity 95.6%, and specificity
of 93.7%. |
|
|
Azam, F, Taban, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The current study seeks to employ molecular docking, molecular mechanics generalized Born surface area (MM-GBSA) analysis
and molecular dynamics simulation studies for decrypting the binding mode, key interacting residues as well as mechanistic insights on ivermectin (IVM) interaction with 15 potential drug targets associated with COVID-19 as well as IMPα. Among all COVID-19
targets, the non-structural protein 9 (Nsp9) exhibited the strongest affinity to IVM showing −5.30 kcal/mol and −84.85 kcal/mol binding energies estimated by AutoDock Vina and MM-GBSA, respectively. However, moderate affinity was accounted for IMPα amounting
−6.9 kcal/mol and −66.04 kcal/mol. |
|
|
Badr, DA, Mattern, et al |
Am J Obstet Gynecol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of our study was to compare the clinical outcomes and laboratory findings of pregnant women at ≥20 weeks’
gestation infected with SARS-CoV-2 with a cohort of nonpregnant women with a confirmed diagnosis of COVID-19 after closely matching the 2 groups using a propensity score. This was a retrospective study conducted in the following 4 large university hospitals
in France and Belgium between January 1, 2020, and May 13, 2020. Inclusion criterion was female patients of reproductive age with positive SARS-CoV-2 infection confirmed by real-time polymerase chain reaction tests of nasopharyngeal swab samples. The study
included 190 eligible patients for the final analysis who were divided into the following 2 groups: a nonpregnant control group 1 (107 patients) and the pregnant case group 2 (83 patients). The incidences of fever and cough did not differ significantly between
the 2 groups (57.8% vs 60.6% [P=.765] and 78.3% vs 73.1% [P=.495], respectively). Dyspnea, anosmia or ageusia, fatigue and myalgia, upper respiratory tract symptoms, gastrointestinal symptoms, and other symptoms, such as headache, chest discomfort, and cutaneous
rash, were all significantly lower in pregnant women. Moreover, there was significant difference of hemoglobin level, AST, ALT, C-reactive protein (CRP), creatinine, and D-dimers between the 2 groups. Other laboratory test results were similar in both the
groups. Pregnant women were at higher risk for ICU admission than nonpregnant women (11.08% vs 2.38%; P=.024). In addition, they were also at higher risk for hospital admission because of COVID-19 respiratory decompensation such as dyspnea and hypoxemia (58.21%
vs 17.4%; P<.001), for the need for OT (36.04% vs 17.24%; P=.006), and for ETI (10.16% vs 1.67%; P=.022). Our propensity score–matched case-control study has indicated that pregnant women diagnosed with COVID-19 at ≥20 weeks’ gestation have more severe outcomes
than their nonpregnant counterparts. |
|
|
Bakovic, Alison, Risner, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This manuscript describes the potent antiviral activity exerted by brilacidin−a de novo designed synthetic small molecule
that captures the biological properties of HDPs−on SARS-CoV-2 in a human lung cell line (Calu-3) and a monkey cell line (Vero). These data suggest that SARS-CoV-2 inhibition in these cell culture models is primarily a result of the impact of brilacidin on
viral entry and its disruption of viral integrity. Brilacidin has demonstrated synergistic antiviral activity when combined with remdesivir. Brilacidin potently inhibits SARS-CoV-2 in an ACE2 positive human lung cell line. Brilacidin achieved a high Selectivity
Index of 426 (CC50=241µM/IC50=0.565µM). Brilacidin's main mechanism appears to disrupt viral integrity and impact viral entry. |
|
|
Banzi, R, Sala, et al |
Recenti progressi in medicina |
Healthcare Response | Réponse des soins de santé |
Adult symptomatic patients with suspected or confirmed CoViD-19 for whom it was decided not to proceed to hospitalization
were evaluate to see if home care and monitoring ensured rapid and adequate transfer to hospital care. The cases collected were not sufficient to demonstrate or refute the hypothesis of the monitoring test effectiveness. |
|
|
Barlow, Jonathan, Vodenska, et al |
SSRN- Lancet prepublication |
Economics | Économie |
In this work, we propose a dynamic cascade model to investigate the systemic risk posed by sector level industries
within the U.S. inter-industry network. We then use this model to study the effect of the disruption presented by COVID-19 on the U.S. economy. We construct a weighted digraph G = (V;E;W) using the industry-by-industry total requirements table for the year
2018, provided by the Bureau of Economic Analysis. We impose an initial shock that disrupts the production capacity of one or more industries and calculate the propagation of production shortage with a modified Cobb-Douglas production function. In the case
of COVID-19, the initial shock is modeled on the loss of labor between March and April 2020, as reported by the Bureau of Labor Statistics. The industries within the network are assigned a resilience r that determines the ability of an industry to absorb input
losses, such that if the rate of input loss exceeds the resilience r, the industry fails and its outputs go to zero. We observe a critical resilience rc, such that below this critical value the network experiences a catastrophic cascade resulting in total
network collapse. |
|
|
Baumer, T, Phillips, et al |
Frontiers in Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We prospectively recorded the rate of ICU admissions of 52 patients with COVID-19 over 60 days, focusing on the epidemiology
of ethnicity and deprivation because these factors have emerged as significant risk factors. COVID-19 hospital and ICU inpatient numbers peaked on days 23 and 39, respectively—a lag of 16 days. The ICU mortality rate was 33% (17 of 52). People of black, Asian,
and minority ethnic descent (BAME group) represented 35% of ICU COVID-19 admissions (18 of 52) and 35% of deaths (6 of 17). Amongst the BAME group, 72% (13 of 18) of patients were found to reside in geographical areas representing the 20% most deprived in
Wales, vs. 27% of patients in the Caucasian group (9 of 33). |
|
|
Viral genome sequencing places White House COVID-19
outbreak into phylogenetic context |
Bedford, Trevor, Logue, et al |
medRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
In October 2020, an outbreak of at least 50 COVID-19 cases was reported surrounding individuals employed at or visiting
the White House. Here, we applied genomic epidemiology to investigate the origins of this outbreak. We find these viral sequences are highly genetically similar to each other, but are distinct from over 160,000 publicly available SARS-CoV-2 genomes, possessing
5 nucleotide mutations that differentiate this lineage from all other circulating lineages sequenced to date. |
|
Beglaibter, N, Zelekha, et al |
Isr J Health Policy Res |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to portray the practices and attitudes of Israeli bariatric surgeons in the first phase of
the pandemic through an online survey (n=53). In the public sector, 86% of the surgeons ceased to operate while 14% did not comply with the government’s decree. In the public sector 69% of the surgeons were instructed by the administrators to stop operating.
The majority of surgeons who continued to operate (77%) changed nothing in the indications or contra-indications for surgery. Roughly only half (57%) of the surgeons implemented changes in informed consent and operating room (OR) measures, contrary to guidelines
and recommendations by leading professional societies. When asked about future conditions for reestablishing elective procedures, the reply frequencies were as follows: no special measures - 40%; PCR negativity - 27%; IgG positivity - 15%; waiting until the
end of the pandemic- 9%. |
|
|
In silico identification of strong binders of the SARS-CoV-2 receptor-binding
domain |
Behloul, N, Baha, et al |
Eur J Pharmacol |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
we performed molecular docking and structure-based virtual screening of libraries of approved drugs, antivirals, inhibitors
of protein-protein interactions, and one million other small molecules to identify strong binders of the SARS-CoV-2 receptor-binding domain (RBD) that might interfere with the receptor recognition process, so as to inhibit the viral cellular entry. According
to our screening and selection criteria, three approved antivirals (elbasvir, grazoprevir, and sovaprevir) and 4 other drugs (hesperidin, pamaqueside, diosmin, and sitogluside) were identified as potent binders of the RBD. |
|
Bhattarai, Apurba, Pawnikar, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Despite the critical importance, the mechanism of ligand binding to the human ACE2 receptor remains unknown. This research
addresses the challenge through all-atom simulations using a novel ligand Gaussian accelerated molecular dynamics (LiGaMD) method. Microsecond LiGaMD simulations have successfully captured both binding and unbinding of the MLN-4760 inhibitor in the ACE2 receptor.
In the ligand unbound state, the ACE2 receptor samples distinct Open, Partially Open and Closed conformations. Ligand binding biases the receptor conformational ensemble towards the Closed state. The LiGaMD simulations thus suggest a conformational selection
mechanism for ligand recognition by the ACE2 receptor. |
|
|
Výroba
a použití rekonvalescentní plazmy anti-sars-cov-2 v Čr |
Bohoněk, M, Bělochová, et al |
Transfuze a Hematologie Dnes |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Causal treatment and prophylaxis of COVID-19 caused by SARS-CoV-2 continues to be the subject of clinical research
and development. A promising method, widely used in many countries, is the administration of convalescent plasma (RP) from individuals who have undergone COVID-19. In the period from 20 April to 30 June 2016, 11 TSGs were involved in DP production in the Czech
Republic, which carried out a total of 275 donors for DP production, mainly by apheresis, and 686 TU were produced, of which 302 TU were treated with pathogen by inactivation. So far, 41 patients have undergone treatment for RP, who have received a total of
95 TU RP. No adverse reactions have been reported and the clinical response is still under detailed evaluation. |
|
Bönisch, S, Wegscheider, et al |
Frontiers in Public Health |
Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions
de sant&eacute; publique |
Authors have investigated the association of mobility with the number of new cases and the reproduction number of COVID-19.
Other behavioral changes, e.g., wearing masks, individual distancing, or general awareness of the COVID-19 hazards may have contributed to the observed further reduction in case numbers and constant reproduction numbers below one until mid-July. |
|
|
COVID-19 pandemic and dental hygienists in Italy: a questionnaire survey |
Bontà, G, Campus, et al |
BMC Health Serv Res |
Healthcare Response | Réponse des soins de santé |
This online cross-sectional survey assessed the signs/symptoms, the protective measures taken and the awareness and
risk perception regarding COVID-19 among Italian dental hygienists. Two-thousand-seven-hundred-ninety-eight subjects participated. Only 0.25% of the sample was positive to the virus. Sense of fatigue (8.19%), headache (7.81%) and sore throat (7.32%) were the
most common symptoms. A statistically significant trend across the areas with a different prevalence of COVID-19 was observed related to the number of signs/symptoms (areas z = 6.38 p < 0.01). Overall, 90.55% of the sample used protective glasses or visor,
90.10% disposable gloves and 82.80% surgical mask. Regarding the confidence to avoid the infection, a statistically significant difference was found among dental hygienists belonging to the 3 years-professional-experiences groups who worked in the high COVID-19
prevalence area. |
|
Bontadi, D, Bergamo, et al |
Med Lav |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
The study was aimed at verifying the effectiveness of measures to contain the virus spread among workers in the workplace.
A survey was promoted in nine manufacturing companies in the province of Padua, to investigate the prevalence of asymptomatic SarsCov-2 virus and the immunological status of 1,267 workers. Swab-positive workers were 0.3%, and subjects with positive serological
tests were 1.6% of the total workers examined. |
|
|
Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal |
Borges, V, Isidro, et al |
Emerg Microbes Infect |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Here, we track the geotemporal spread of a SARS-CoV-2 variant with a mutation (D839Y) in a potential host-interacting
region involving the Spike fusion peptide, which is a target motif of anti-viral drugs that plays a key role in SARS-CoV-2 infectivity. The Spike Y839 variant was most likely imported from Italy in mid-late February and massively disseminated in Portugal
during the early epidemic, becoming prevalent in the Northern and Central regions of Portugal where it represented 22% and 59% of the sampled genomes, respectively, by April 30(th). Based on our high sequencing sampling during the early epidemics 15.5% and
6.0% of all confirmed cases until the end of March and April, respectively, we estimate that, between March 14(th) and April 9(th) the relative frequency of the Spike Y839 variant increased at a rate of 12.1% every three days, being potentially associated
with 24.8% of all COVID-19 cases in Portugal during this period. |
|
Bosaeed, M, Mahmoud, et al |
Trials |
RCT |
Clinical trial application. Aim to investigate the clinical effectiveness of the combination of Favipiravir and Hydroxychloroquine
in SARS-CoV-2 as therapy. The primary endpoint is the time to clinical improvement, defined as the time from randomization to an improvement of two points (from the status at randomization) on a seven-category ordinal scale or live discharge from the hospital,
whichever came first (14 days from Randomization). |
|
|
What are the Economic Effects of Pandemic Containment Policies?
Evidence from Sweden |
Bricco, Jana, Misch, et al |
SSRN- Lancet prepublication |
Public health interventions*| Interventions de sant&eacute; publique Economics
| Économie |
This paper examines the economic effects of policies to contain Covid-19, by extracting lessons from Sweden's experience
during the ‘Great Lockdown'. Sweden's approach was less stringent and based more on social responsibility than legal obligations compared to European peers. First, we provide an account of Sweden's strategy and the health outcomes. Second, drawing on a range
of data sources and empirical findings, our analysis of the first Covid-19 wave indicates that a less stringent strategy can soften the economic impact initially. These benefits could be eroded subsequently, due to potentially higher infection rates and a
prolonged pandemic, but in Sweden's case, the evidence remains mixed in this regard, and it is premature to judge the outcome of Sweden's containment strategy. In addition, the economic effects of the containment strategy also depend on social behavior, demographics
and structural features of the economy, such as the degree of export orientation, reliance on global supply chains, and malleability to remote working. |
|
Asymptomatic hypoxia in COVID-19 is associated with poor outcome |
Brouqui, P, Amrane, et al |
Int J Infect Dis |
Clinical data| Données cliniques |
The objective of this study is to describe and evaluate the outcome of COVID patient without shortness of breath. The
absence of shortness of breath in old patient with co-morbidity merit medical attention and should not be considered as a good sign of wellbeing. |
|
Burger, P, Calitz, et al |
South African Journal of Economics |
Economics | Économie |
Following years of fast-rising debt levels, we show that the Covid-19 crisis worsened an already deteriorating fiscal
position in South Africa. To restore fiscal sustainability in the aftermath of the crisis some commentators argue that higher government expenditure will grow GDP sufficiently to stabilise the debt/GDP ratio. We reject this, showing that although a real increase
in expenditure stimulates economic growth (a short-run, once-off effect), the public expenditure/GDP ratio exceeds the level at which an increase in the ratio positively impacts growth. We then explore the past efforts of government to maintain or restore
fiscal sustainability by estimating a fiscal reaction function using a Markov-switching model. Following the impact of the Covid-19 crisis on the budget, we subsequently establish the deficit, expenditure and revenue adjustments that the government will have
to make to restore fiscal sustainability. Finally, we consider the merits of introducing a debt ceiling. © 2020 Economic Society of South Africa |
|
|
Campos-Barrera, E, Alvarez-Cisneros, et al |
Case Reports in Endocrinology |
Clinical data| Données cliniques |
We hereby describe the case of a previously healthy 37-year-old female presenting with subacute thyroiditis associated
with a very mild presentation of COVID-19. As most patients with SARS-Cov-2 are asymptomatic, we suggest to rule out SARS-Cov-2 infection in patients presenting with symptoms suggesting SAT. |
|
|
Herpes zoster and postherpetic neuralgia in an elderly patient with critical COVID-19:
A case report |
Cao, X, Zhang, et al |
Journal of Pain Research |
Long-Term Sequelae |
|
We describe clinical features, treatments and outcome of herpes zoster as well as postherpetic neuralgia in a 70-year-old
woman with critical COVID-19. She developed herpes zoster in the right 10 to 12 lumbar dermatomes in the recovery period of COVID-19. Our case draws attention to postherpetic neuralgia in COVID-19 patients and provides a targeted suggestion for this kind
of patients. |
|
Cariou, B, Goronflot, et al |
Diabetes and Metabolism |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The study reported here specifically assessed the association between routine statin use and COVID-19-related outcomes
in inpatients with T2DM. Methods: The Coronavirus–SARS-CoV-2 and Diabetes Outcomes (CORONADO) study was a nationwide observational study aiming to describe the phenotypic characteristics and prognosis of T2DM patients with COVID-19 admitted to 68 French hospitals
between 10 March and 10 April 2020. Results: Of the 2449 patients with T2DM (881 women, 1568 men; aged 70.9 ± 12.5 years) suitable for analysis, 1192 (49%) were using statin treatment before admission. In unadjusted analyses, patients using statins had rates
of the primary outcome similar to those of non-users within both 7 and 28 days of admission. However, mortality rates were significantly higher in statin users within 7 and 28 days |
|
|
Rural community pharmacies’ preparedness for and responses to COVID-19 |
Carpenter, DM, Hastings, et al |
Research in Social and Administrative Pharmacy |
Healthcare Response | Réponse des soins de santé |
The study describes rural community pharmacies’ preparedness for and responses to COVID-19 and examines whether responses
vary by level of pharmacy rurality. Pharmacists used the CDC (87%), state health departments (77%), and state pharmacy associations (71%) for COVID-19 information, with half receiving conflicting information. Most (78%) were interested in offering COVID-19
testing but needed personal protective equipment and training to do so. Only 10% had received disaster preparedness training in the past five years, and although 73% had disaster preparedness plans, 27% were deemed inadequate for the pandemic. Nearly 70% experienced
negative impacts in medication supply. |
|
Why we should be more careful using hydroxychloroquine in influenza season? |
Çelik, HG, Keske, et al |
Int J Infect Dis |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We aimed to describe the QTc prolongation and related adverse cardiac events during the administration of hydroxychloroquine
(HCQ) and its combinations for treatment of COVID-19. The hospitalized patients who were infected with SARS-CoV-2 and received HCQ with initial and follow up ECGs from March 10(th) to May 30(th) were included. Critical QTc prolongation was detected in 12%
of the patients. In multivariate analysis, Diabetes Mellitus (Odds Ratio:5.8, 95% Confidence Interval:1.11-30.32, p = 0.037), and use of oseltamivir (OR:5.3, 95% Cl:1,02-28, p:0.047) were found to be associated with critical QTc prolongation. |
|
Investigating Anxiety Disorders in Farmers in Turkey During COVID-19
Pandemic |
Cevher, Celal, Altınkaynak, et al |
SSRN- Lancet prepublication |
Mental Health |
|
Evaluated the anxiety disorders of farmers in Turkey during COVID-19 and investigate factors affecting it. A survey
with 2125 farmers was conducted during the pandemic. All farmers had different levels of anxiety disorders. Most farmers had serious (moderate and severe) anxiety disorders. In the ordinal logistic regression analysis, anxiety decreased with an increase in
age. The odds ratio (OR) for the age range of 41–50 years was 1.452 when compared to the age range of 61 years and older. Anxiety disorder was higher in rural farmers than in urban residents and lower in farmers who had medium or low income compared to high
income farmers. The anxiety of farmers engaged in animal and vegetable production was significantly higher than those in mixed production, and anxiety in farmers engaged in crops production was lower than that of mixed producers. Anxiety levels were higher
in livestock farmers and farmers who owned trucks. Obtaining technical support from agricultural organizations, neighbor support, and having strong social support were identified as factors to reduce anxiety. |
|
Carcinoembryonic Antigen: A Potential Biomarker to Evaluate the Severity and Prognosis
of COVID-19 |
Chen, Q, Kong, et al |
Frontiers in Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective study aimed to indicate the values of carcinoembryonic antigen (CEA) in evaluating the severity
and prognosis of COVID-19. Methods: We included 46 death cases from intensive care unit and 68 discharged cases from ordinary units with confirmed COVID-19 of Wuhan Jin Yin-tan Hospital from January 1 to March 22, 2020. Results: COVID-19 patients in the death
group had significantly higher CEA levels (ng/ml) than discharged group. The risk of COVID-19 death increased 1.317 times for each additional 1 ng/ml CEA level. |
|
Novel insight from the first lung transplant of a COVID-19 patient |
Chen, XJ, Li, et al |
Eur J Clin Invest |
Clinical data| Données cliniques |
To reveal detailed histopathological changes, virus distributions, immunologic properties, and multi-omic features
caused by SARS-CoV-2 in the explanted lungs from the world's first successful lung transplantation of a COVID-19 patient. A total of 36 samples were collected from the lungs. RESULTS: The histopathological changes of the lung tissues were characterized by
extensive pulmonary interstitial fibrosis and hemorrhage. Viral particles were observed in the cytoplasm of macrophages. CD3(+) CD4(-) T cells T cells, neutrophils, NK cells, γ/δ T cells and monocytes, but not B cells, were abundant in the lungs. |
|
A cell-free antibody engineering platform rapidly generates
SARS-CoV-2 neutralizing antibodies |
Chen, Xun, Gentili, et al |
bioRxiv |
Therapeutics| Thérapeutique Immunology | Immunologie |
This research developed CeVICA, a cell-free antibody engineering platform that integrates a novel generation method
and design for camelid heavy-chain antibody VHH domain-based synthetic libraries, optimized in vitro selection based on ribosome display and a computational pipeline for binder prediction based on CDR-directed clustering. Applied CeVICA to engineer antibodies
against the Receptor Binding Domain (RBD) of the SARS-CoV-2 spike proteins and identified >800 predicted binder families. Among 14 experimentally-tested binders, 6 showed inhibition of pseudotyped virus infection. Antibody affinity maturation further increased
binding affinity and potency of inhibition. |
|
Ciocan, C, Clari, et al |
Med Lav |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
OBJECTIVES: To evaluate the impact of Respiratory Protective Devices (RPD) on the respiratory function in healthy and
asthmatic subjects, in order to identify the fitness for use. Observed RFTs and ABG parameters did not suffer significant variations, but for Maximal Voluntary Ventilation (P=0.002). |
|
|
Clarke, J, Murray, et al |
BMJ Open |
Healthcare Response | Réponse des soins de santé |
This study applied Markov multiscale community detection (MMCD), an unsupervised graph-based clustering framework,
to identify new surgical care models based on pooled waiting-lists delivered across an expanded network of surgical providers. A total of 7 811 891 planned operations were identified in 4 284 925 adults during the 1-year period of our study. The 28 most common
surgical procedures accounted for a combined 3 907 474 operations (50.0% of the total). 2 412 613 (61.7%) of these most common procedures involved 'low risk' patients. Patients travelled an average of 11.3 km for these procedures. Based on the data, MMCD partitioned
England into 45, 16 and 7 mutually exclusive and collectively exhaustive natural surgical communities of increasing coarseness. The coarser partitions into 16 and seven surgical communities were shown to be associated with balanced supply and demand for surgical
care within communities. |
|
|
Perspectives from the frontline: A pharmacy department's response to the COVID-19 pandemic |
Collins, CD, West, et al |
American Journal of Health-System Pharmacy |
Healthcare Response | Réponse des soins de santé |
The purpose of this report is to describe our institution's strategy to deploy pharmacy resources and standardize pharmacy
processes to optimize the management of patients with COVID-19. This retrospective, descriptive report characterizes documented pharmacy interventions in the acute care of patients admitted for COVID-19 during the period April 1 to April 15, 2020. A total
of 1,572 pharmacist interventions were documented in 197 patients who received a total of 15,818 medication days of therapy during the study period. The average number of interventions per patient was 8. The most common interventions were regimen simplification
(15.9%), timing and dosing adjustments (15.4%), and antimicrobial therapy and COVID-19 treatment adjustments (15.2%). Patients who were admitted to an intensive care unit care at any point during their hospital stay accounted for 66.7% of all interventions
documented. Pharmacists intervened to address a wide scope of medication-related issues, likely contributing to improved management of COVID-19 patients. |
|
Conway, J, Gould, et al |
Int J Clin Pract |
Clinical data| Données cliniques |
Authors collected the demographics and medical characteristics of all COVID-19 positive cases admitted over two-week
period. This case series demonstrated that the characteristics of British COVID-19 patients were generally similar to what is published in literature although we report more gastrointestinal symptoms at presentation. |
|
|
Coto, J, Restrepo, et al |
PLoS One |
Mental Health |
|
The purpose of the current study was to examine the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2
or COVID-19) on allied health professionals work environment, access to personal protective equipment (PPE) and COVID-19 testing, and mental health. Importantly, 86% of all respondents, irrespective of employment status, reported feeling stressed with regards
to changes in their work environment and transmission of the virus. However, levels of stress were dependent upon access to PPE and mental health resources. |
|
|
Crolley, VE, Hanna, et al |
Therapeutic Advances in Medical Oncology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Investigated the outcomes of patients receiving systemic anti-cancer treatments (SACT) to assess whether they were
at greater risk of contracting COVID-19 or having more severe outcomes. A total of 2871 patients receiving SACT from 2 March to 31 May 2020 were analysed; 68 were diagnosed with COVID-19. Cancer patients receiving SACT were more likely to die if they contracted
COVID-19 than those who did not adjusted (adj.) odds ratio (OR) 9.84. Receiving chemotherapy increased the risk of developing COVID-19 (adj. OR 2.99), with high dose chemotherapy significantly increasing risk (adj. OR 2.36), as did the presence of comorbidities
(adj. OR 2.29), and having a respiratory or intrathoracic neoplasm (adj. OR 2.12). Receiving targeted treatment had a protective effect (adj. OR 0.53). Treatment intent (curative versus palliative), hormonal- or immunotherapy and solid versus haematological
cancers had no significant effect on risk. |
|
|
Cuevas-Ferrando, E, Pérez-Cataluña, et al |
Science of the Total Environment |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In this study, suitable options to investigate coronavirus in tap water, seawater and surface water were assessed.
We assessed the analytical performance of a Dead End Hollow Fiber Ultrafiltration (DEUF) concentration and two quantitative RT-qPCR detection kits with the final aim of developing a tool of interest for studying the potential SARS-CoV-2 contamination of different
types of water. The study reports the analytical performances of several modifications of a DEUF method to concentrate viruses from large volumes of tap water, seawater and surface waters of interest for studying the potential contamination of water resources
by SARS-CoV-2. |
|
|
Cypryańska, M, Nezlek, et al |
PLoS One |
Mental Health |
|
Results suggest that emotional reactions to perceived threats (such as the COVID-19 pandemic) can serve as an instrumental
function by providing the motivation to engage in coping behaviors. |
|
|
D’Angelo, F, Monestier, et al |
Indian Journal of Orthopaedics |
Healthcare Response | Réponse des soins de santé |
The purpose of the article was to document the adopted corporate protocol and describe the management of the traumatized
patient in a Hub center. The correct management of the hospital and the meticulous organization of the traumatized patient have made it possible to contain the potential negative effects on the medical care quality during this unexpected and severe health
emergency. |
|
|
da Costa, CAS |
Nutrition and Food Science |
Clinical data| Données cliniques |
This paper aims to describe the likely positive effects of alpha-linolenic acid (ALA) supplementation on the lung and
the negative effects of it on the adipose tissue of COVID-19 patients. ALA can help human respiratory system by improving lung damage. On the other hand, when it comes to adipose tissue, it can induce the overexpression of glucose transporter-4 gene and impair
COVID-19 prognosis. |
|
|
Danielis, M, Palese, et al |
Assistenza Infermieristica e Ricerca : AIR |
Healthcare Response | Réponse des soins de santé |
AIMS: To investigate (1) the organizational changes of hospitals and ICUs in dealing with the Covid-19 outbreak; (2)
the characteristics of the nursing care; (3) the most important challenges perceived by nurses in caring for Covid-19 patients. RESULTS: A total of 62 nurses responded to the survey; average age 37.5 years, 31 (60.8%) were female, mostly from Italy, France
and United Kingdom. The number of ICU beds doubled during the pandemic (p<0.01), as well as the number of nurses per shift from 10.2 (SD 7.3) before to 17.9 (SD 13.6) during the pandemic (p<0.01). However, changes in the nurse-to-patient ratio were not significant:
from 1:1.5 to 1:2 (p=0.05). Among nursing care activities, clinical risk management (n=14, 22.6%), psychological support for patients (n=22, 35.5%) and family's involvement (n=31, 50%) resulted as more challenging; 64.5% of nurses suffered from protective
equipment shortages, and 66.1% experienced psychological burden. |
|
|
Das, AK, Mishra, et al |
PeerJ |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
To predict mortality among confirmed CoVID-19 patients in South Korea using machine learning and deploy the best performing
algorithm as an open-source online prediction tool for decision-making. Mortality for confirmed CoVID-19 patients (n = 3,524) between January 20, 2020 and May 30, 2020 was predicted using five machine learning algorithms; and the best performing algorithm
was deployed as an online prediction tool. This tool can be utilized by potential stakeholders such as health providers and policymakers to triage patients at the community level in addition to other approaches. |
|
|
de Koning, Enrico, Boogers, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
All emergency medical service (EMS) rides for chest pain and out-of-hospital cardiac arrest (OHCA) in the Dutch region
Hollands-Midden (population served >800.000) were evaluated during the initial 6 weeks of the COVID-19 lockdown and compared to the same period in 2019 in two cohorts. During the COVID-19 lockdown, there was a significant decrease in patients with chest pain
evaluated by the EMS paralleled by a reduction in STEMIs, while the incidence of OHCA remained similar. While the reason for the decrease in chest pain and STEMI consultations is not entirely clear, more attention should be drawn to the importance of contacting
the EMS in case of suspected cardiac symptoms in possible future lockdowns. |
|
|
De la Sen, M, Ibeas, et al |
Symmetry |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
This paper firstly studies an SIR (susceptible-infectious-recovered) epidemic model without demography and with no
disease mortality under both total and under partial quarantine of the susceptible subpopulation or of both the susceptible and the infectious ones in order to satisfy the hospital availability requirements on bed disposal and other necessary treatment means
for the seriously infectious subpopulations. Such a model is evaluated under total or partial quarantines of all or of some of the subpopulations which have the effect of decreasing the number of contagions. Simulated numerical examples are also discussed
related to model parameterizations of usefulness related to the current COVID-19 pandemic outbreaks. |
|
|
De Natale, Giuseppe, De Natale, et al |
medRxiv |
Epidemiology| Épidémiologie |
The coronavirus (COVID-19) pandemic was particularly invasive in Italy during the period between March and late April
2020 then decreased in both in the number of infections and in the seriousness of the illness throughout the summer of 2020. In this discussion, we measure the severity of the disease by the ratio of Intensive Care Units (ICU) spaces occupied by COVID-19 patients
and the number of Active Cases (AC) each month from April to October 2020. We also use the ratio of the number of Deaths (D) to the number of Active Cases. What clearly emerges, from rigorous statistical analysis, is a progressive decrease in both ratios until
August, indicating progressive mitigation of the disease. This is particularly evident when comparing March-April with July-August; during the summer period the two ratios became roughly 18 times lower. We then interpret such evidence in terms of the well-known
seasonality of the human immune system and the virus-inactivating effect of stronger UV rays in the summer. Both ratios, however, increased again in October as ICU/AC began to increase in September 2020. |
|
|
De Rosa, Anna, Verrengia, et al |
Research Square prepub |
Clinical data| Données cliniques |
28.6% patients had raised serum CK levels, and 14.3% had muscular manifestations, of which 13.2% complained fatigue
and 2.8% had myalgia and/or arthralgia. CK levels were significantly associated with respiratory involvement and fatal outcome.The study provides preliminary evidence that hyperckemia is a predictor of respiratory involvement and fatal outcome in patients
with COVID-19 infection. For patients with muscle damage symptoms, screening for COVID-19 infection is recommended together with the dosage of CK level. |
|
|
Assessment of air and surfaces contamination
in a COVID-19 non-Intensive Care Unit |
Declementi, M, Godono, et al |
Med Lav |
Epidemiology| Épidémiologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
This is the first Italian study aiming to assess the magnitude of environmental contamination in a COVID-19 non-Intensive
Care Unit. All samples obtained from surfaces and air before and after extra-ordinary sanitization procedures turned out negative for viral detection. These findings highlight the efficiency of ordinary cleaning procedures in guaranteeing a safer workplace. |
|
Knowledge on COVID 19 among the healthcare professionals in South Indian States |
Deepalakshmi, M, Ajay Samraj, et al |
International Journal of Research in Pharmaceutical Sciences |
Healthcare Response | Réponse des soins de santé |
This study was carried out to assess the knowledge of HCWs of the 5 south Indian states with higher rates of COVID-19
infection. An online survey with 25 validated questions about COVID-19 was administered to 385 HCWs across the study region. The overall knowledge about COVID-19 was found to be greater among the medical doctors, pharmacists and nurses from higher to lower
scores with a mean value of 78.81±13.45 compared to the other health-care workers 63.6±24.3. The one-way ANOVA revealed that the difference in the knowledge levels among the HCWs significantly differed (p=0.0012). The answers to few of the questions were found
to be highly dynamic as the advisory guidelines are highly dynamic. The present knowledge level of HCWs in south India about COVID-19 is relatively high. |
|
Delle Donne, Valentina, Ciccarelli, et al |
Research Square prepub |
Mental Health |
|
Explore the psychological impact of the 2019 Coronavirus Disease (COVID-19) on People Living with HIV (PLWH), a population
at increased risk of psychological distress. Almost half of the PLWH sample (n=98) experienced significant levels of distress related to COVID-19 pandemic. Women and those with recent HIV diagnosis seem the more psychological fragile subgroup. Our findings
could help to identify patients most in need of psychological interventions to improve wellbeing of PLWH. |
|
|
Interpreting glottal flow dynamics for detecting COVID-19 from voice |
Deshmukh, Soham, Al Ismail, et al |
arXiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This paper proposes a method that analyzes the differential dynamics of the glottal flow waveform (GFW) during voice
production to identify features in them that are most significant for the detection of COVID-19 from voice. Since it is hard to measure this directly in COVID-19 patients, we infer it from recorded speech signals and compare it to the GFW computed from physical
model of phonation. For normal voices, the difference between the two should be minimal, since physical models are constructed to explain phonation under assumptions of normalcy. Greater differences implicate anomalies in the bio-physical factors that contribute
to the correctness of the physical model, revealing their significance indirectly. Our proposed method uses a CNN-based 2-step attention model that locates anomalies in time-feature space in the difference of the two GFWs, allowing us to infer their potential
as discriminative features for classification. The viability of this method is demonstrated using a clinically curated dataset of COVID-19 positive and negative subjects. |
|
Coronavirus Disease 2019 in Pregnancy: The Experience at an Urban Safety Net Hospital |
Dhuyvetter, A, Cejtin, et al |
J Community Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The purpose of this study is to characterize COVID-19 infection in pregnancy in a population of women getting prenatal
care at an urban safety-net hospital. Beginning in April, 2020, all women were tested at admission for delivery, and additionally as an outpatient if presenting with COVID-19 symptoms. In three months, there were 208 discrete women tested and 23 (11.1%) who
were positive for COVID-19. The incidence of COVID-19 was 5.1% in asymptomatic women being screened upon admission to the hospital. There was a high prevalence of obesity (68.2%) and other comorbid conditions (43.5%) in this population, and all patients were
racial/ethnic minorities. Despite these risk factors, the patients uniformly had either mild or asymptomatic disease. No symptomatic patients required hospitalization for their infection. In this population of pregnant women at high risk for severe COVID-19
infection, only mild disease was observed. |
|
Díez-Fuertes, F, Iglesias-Caballero, et al |
J Virol |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Multiple SARS-CoV-2 introductions have been detected in Spain and at least four resulted in the emergence of locally
transmitted clusters originated not later than mid-February, with further dissemination to many other countries around the world and a few weeks before the explosion of COVID-19 cases detected in Spain during the first week of March. The majority of the earliest
variants detected in Spain branched in 19B clade (D614 viruses), which was the most prevalent clade during the first weeks of March, pointing to a founder effect. However, from mid-March to June, 2020, G614-bearing viruses (20A, 20B and 20C clades) overcame
D614 variants in Spain, probably as a consequence of an evolutionary advantage of this substitution in the spike protein. A higher infectivity of G614-bearing viruses compared to D614 variants was detected, suggesting that this substitution in SARS-CoV-2 spike
protein could be behind the variant shift observed in Spain. |
|
|
Dores, AR, Geraldo, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
This survey study aimed to explore Portuguese psychologists’ practices related with the use of digital information
and communication technologies (ICTs) before and during the COVID-19 lockdown, to identify the main changes that the pandemic has brought and the impact that such changes have had on their practice with clients, and also identify the factors that potentially
have affected such changes. The results showed that these professionals continued to provide their services because they adopted ICTs. Comparing with face-to-face interventions, psychologists recognized that additional precautions/knowledge were needed to
use such technologies. Despite the challenges identified, they described the experience with the use of ICTs as positive, meeting clients’ adherence, and yielding positive results |
|
|
Du, P, Ding, et al |
Nat Commun |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Here we present genomic surveillance data on 102 imported cases, which account for 17.2% of the total cases in Beijing.
Genomic comparisons reveal higher genomic diversity in the imported group compared to both the Wuhan exposure and local transmission groups, indicating continuous genomic evolution during global transmission. Epidemiological data suggest that detection of
cases at immigration with mandatory quarantine may be an effective way to prevent recurring outbreaks triggered by imported cases. |
|
|
Performance evaluation of the Simtomax CoronaCheck
rapid diagnostic test |
Ducrest, Percevent Jeremy, Freymond, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The aim of this study was to evaluate the diagnostic performance of Simtomax CoronaCheck, a serology rapid diagnostic
test (RDT) for the detection of IgG and IgM against SARS-CoV-2. Overall, the RDT sensitivity was 92% (95% confidence interval [95%CI]: 79-97), specificity 97% (95% CI: 91-99%), PPV 94% (95% CI: 81-98) and the NPV 96% (95% CI: 89-99). |
|
A Framework for Estimating Health Spending in Response to COVID-19 |
Dudine, Paolo, Hellwig, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique Healthcare Response | Réponse des soins de santé Economics | Économie |
We estimate the additional health spending necessary to treat COVID-19 patients. We expand a Susceptible Infected Recovered
model to project the number of people requiring hospitalization, use information about healthcare costs by country, and make assumptions about capacity constraints in the health sector. Without social distancing and lockdowns, countries would need to expand
health systems ten-fold, on average, to assist all COVID-19 patients in need of hospitalization. Under capacity constraints, effective social distancing and quarantine reduce the additional health spending from a range of $0.6-1 trillion globally to $130-231
billion, and the fatality rate from 1.2 to 0.2 percent, on average. |
|
Emotional Well-being During the First Four Months of COVID-19 in the United States |
Ebert, AR, Bernstein, et al |
Journal of Adult Development |
Mental Health |
|
Adults were surveyed before the pandemic began and at four additional time points throughout the first 4 months of
the COVID-19 outbreak in the United States. We detected changes in both positive affect and negative affect during the first 4 months of COVID-19. The magnitude of these changes suggests that the stress of COVID-19 does not lead to an immediate decrease in
well-being. Moreover, although older adults showed higher positive affect and lower negative affect relative to other adults, age differences in the trajectory of change did not emerge. |
|
Clinical course of COVID-19 among immunocompromised children: a clinical case series |
El Dannan, H, Al Hassani, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
This case series evaluated the clinical and laboratory characteristics, management and outcomes of COVID-19 in five
children immunocompromised due to different underlying conditions. All had mild symptoms or were asymptomatic at presentation. All had a benign course of illness. No changes or delays in their treatment regimens occurred, and none experienced a relapse of
the original disease, developed severe COVID-19 or died. However, these cases showed a prolonged duration of virus shedding. |
|
El Hamichi, S, Gold, et al |
Clinical Ophthalmology |
Healthcare Response | Réponse des soins de santé |
This study aimed to report the impact of COVID-19 on retina practices in three different “hot spot” cities in the United
States. A significant decrease in the number of encounters and injections was revealed in all three centers involved in this review. There was a decrease of 87% in encounters (156 patients were seen only) and a decrease of 58% (126 patients) in intravitreal
injections in Weill Cornell Medical College in NYC and a decline of 59% (569 patients) in encounters and a decrease of 64% (280 patients) of intravitreal injections at the Ophthalmic Consultants of Boston and Tufts University School of Medicine in Boston.
The decline at Miami Ocular Oncology & Retina in Miami was 37% (1198 patients) in the encounters and 30% (867 patients) in the injections. |
|
|
COVID-19 patients and contacted person awareness about home quarantine instructions |
Elgendy, MO, Abd Elmawla, et al |
Int J Clin Pract |
Public Health response| Interventions de santé publique |
This study aimed to evaluate awareness and practices related to the COVID-19 quarantine instructions among the home
quarantine COVID-19 patients, and persons who contacted them at-home quarantine. Home quarantine COVID-19 patients and people in close contact with them in the study had a good awareness of the home quarantine instructions. |
|
Novel feature selection and voting classifier algorithms for COVID-19 classification
in CT images |
El-Kenawy, E, Ibrahim, et al |
IEEE Access |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This article proposes two optimization algorithms for feature selection and classification of COVID-19. The proposed
feature selection algorithm (SFS-Guided WOA) is compared with other optimization algorithms widely used in recent literature to validate its efficiency. |
|
End-to-end deep learning framework for coronavirus (COVID-19) detection and monitoring |
El-Rashidy, N, El-Sappagh, et al |
Electronics (Switzerland) |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes Healthcare Response | Réponse des soins de santé |
By monitoring a person with COVID-19 in real time, physicians can guide patients with the right decisions. The proposed
framework has three main layers (i.e., a patient layer, cloud layer, and hospital layer). In the patient layer, the patient is tracked through a set of wearable sensors and a mobile app. In the cloud layer, a fog network architecture is proposed to solve
the issues of storage and data transmission. In the hospital layer, we propose a convolutional neural network-based deep learning model for COVID-19 detection based on patient’s X-ray scan images and transfer learning. The proposed model achieved promising
results compared to the state-of-the art (i.e., accuracy of 97.95% and specificity of 98.85%). |
|
Erdem, H, Lucey, et al |
Int J Infect Dis |
Epidemiology| Épidémiologie |
We performed a survey among members of the ID-IRI (Infectious Diseases International Research Initiative) to ascertain
the number of deaths and number of infected in four categories: Medical Doctors, Medical Nurses, other Medical Staff, as well as the total numbers of HCWs. Data was received from 37 countries and the median of the HCW deaths per 100,000 population of the country
was 0.05. |
|
|
Psychological
features of social fears associated with the covid-19 content of news feed in russia |
Ermolaev, VV, Sorokoumova, et al |
EurAsian Journal of BioSciences |
Mental Health |
|
The purpose of the study lies in the understanding of the psychological features of fear in conditions of forced self-isolation
due to COVID-19. Method of research: we use a questionnaire survey, which allows us to quickly and effectively investigate the level of involvement of the Russian citizens in the content of the news feed about COVID-19; a questionnaire “Social fears” to identify
the level of social fears associated with the fears of failure and defeat, rejection and suppression, loss, communication and independence; and the method of determining the dominant state of DS-8 in order to identify the dominant mental states. . The results
reveal that social fears associated with fears of failure and defeat, rejection and suppression, loss, communication, and independence are more characteristic of the citizens who are actively involved in the information and news feed about COVID-19 broadcasted
in the media, and the Internet. |
|
Esme, P, Akoglu, et al |
J Cosmet Dermatol |
Healthcare Response | Réponse des soins de santé |
We aimed to document the medical and socioeconomic problems emerged in dermatocosmetology clinics in Turkey caused
by COVID-19 pandemic and to discuss the management strategies taken by dermatologists. A remarkable decrease in major cosmetic interest was reported in private clinics; meanwhile, there was an increase in applicants for noncosmetic dermatological complaints.
The most avoided cosmetic procedures were application of skin care devices, lasers, chemical peeling, and thread lifting, while botulinum toxin injection was the most performed procedure. Nearly half of the participants had severe financial damage. Of the
participants, 55% reported that they worked anxiously during this period and 60% believed that they managed the early period of the pandemic successfully. |
|
|
Facchin, F, Contarato, et al |
Assistenza Infermieristica e Ricerca : AIR |
Healthcare Response | Réponse des soins de santé |
This study aimed to describe the interventions implemented to limit the spread of virus during the peak of pandemic
in a high daily turn-over 25 beds surgical ward (9 patient admitted per day/mean duration of hospital stay 2.3 days). 392 patients were treated in the period considered (342 were scheduled cases - 50 urgent cases; 364 were adults and 28 children). All scheduled
patients underwent a screening survey, 5% of those contacted showed a risk factor at the interview and were rescheduled; 190 patients underwent a preoperative screening swab, all with negative results. None of healthcare providers was positive to swabs. |
|
|
Fahy, S, Moore, et al |
Geriatric Orthopaedic Surgery and Rehabilitation |
Public Health response| Interventions de santé publique |
This is the first study to examine the attitudes of patients to undergoing total joint arthroplasty during the COVID-19
crisis. 86% of patients felt that they were at little to no risk of COVID-19 infection. The majority of patients were happy to proceed with surgery at the current level of COVID-19 related threat (86%). Patients with higher mHHS were more likely to postpone
their operation than those with lower mHHS scores. |
|
|
Alveolar-to-arterial oxygen gradient: role in the management of COVID-19
infection mild population |
Farina, Gabriele, Gianstefani, et al |
Research Square prepub |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Study suggest the application of ABG parameters, in particular alveolar-to-arterial oxygen gradient (AaDO2), during
the first assessment of COVID-19 patients in the ED, because they could be additional tools to help the emergency physician to evaluate the clinical severity of patients. |
|
Fathi, F, Sami, et al |
International Journal of Immunopathology and Pharmacology |
Clinical data| Données cliniques Immunology | Immunologie |
This case-control study investigated how the immune system changes were related to disease severity in COVID-19 patients
in Iran (n=57). Results indicate that the immune system changes during the disease recovery to improve and regulate immune responses and thereby may associate with the reduction in disease severity. |
|
|
Fawaz, M, Samaha, et al |
Nurs Forum |
Mental Health |
|
This study aims at evaluating the prevalence of depression, anxiety, and stress symptomatology among Lebanese University
Students during the COVID‐19 Quarantine. The sudden shift to exclusive e‐learning methods of instruction have produced anxiety and depression symptoms among a significant portion of the students due to the stressful load of work required. |
|
|
Felzen, M, Brockert, et al |
Notarzt |
Healthcare Response | Réponse des soins de santé |
As part of a cohort analysis, the number of emergency and tele-emergency medical operations from March 2020 was compared
with those from March 2018 and 2019 with regard to potentially life-threatening operations. Above all, the number of non-life-threatening minor missions fell in March 2020. Many patients were transported to the hospital by ambulance despite their normal vital
parameters. Increased tele-medical assessments could reduce transports that are not appropriate to the indication. |
|
|
Ferguson, JM, Jacobs, et al |
J Am Med Inform Assoc |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to describe the shift from in-person to virtual care within Veterans Affairs (VA) during
the early phase of the COVID-19 pandemic, and to identify at-risk patient populations who require greater resources to overcome access barriers to virtual care. By June, 58% of VA care was provided virtually compared to only 14% prior. Patients with lower
income, higher disability, and more chronic conditions were more likely to receive virtual care during the pandemic. |
|
|
Nocturnality, seasonality and the SARS-CoV-2 Ecological Niche |
Finlayson, Geraldine, Finlayson, et al |
arXiv |
Epidemiology| Épidémiologie zoonoses |
We examine the distribution of coronaviruses among bats. We analyse the distribution of SARS-CoV-2 in a nine-week period
following lockdown in Italy, Spain, and Australia. We correlate its incidence with environmental variables particularly ultraviolet radiation, temperature, and humidity. We establish a clear negative relationship between COVID-19 and ultraviolet radiation,
modulated by temperature and humidity. We relate our results with data showing that the bat species most vulnerable to coronavirus infection are those which live in environmental conditions that are similar to those that appear to be most favourable to the
spread of COVID-19. The SARS-CoV-2 ecological niche has been the product of long-term coevolution of coronaviruses with their host species. Understanding the key parameters of that niche in host species allows us to predict circumstances where its spread will
be most favourable. Such conditions can be summarised under the headings of nocturnality and seasonality. High ultraviolet radiation, in particular, is proposed as a key limiting variable. We therefore expect the risk of spread of COVID-19 to be highest in
winter conditions, and in low light environments. |
|
Fu, H, Wang, et al |
Int J Infect Dis |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
This data collation effort aims to provide a comprehensive database to describe the epidemic trends and responses during
the first wave of coronavirus disease 2019 (COVID-19) across main provinces in China. Results find that compared to Hubei, the other five most-affected provinces reported a lower crude case fatality ratio and proportion of critical and severe hospitalised
cases. From March 2020, as local transmission of COVID-19 declined, switching the focus of measures to testing and quarantine of inbound travellers could help to sustain the control of the epidemic. |
|
|
Effect of blood analysis and immune function on the prognosis of patients with
COVID-19 |
Fu, YQ, Sun, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
For hospitalized patients with COVID-19, lymphocyte, CD3+ and CD4+ counts that marked decrease suggest a poor outcome
of in-hospital mortality. Admission neutrophil count > 6.3 ×109/L is independently associated with mortality. At admission, leukocyte, neutrophil, lymphocyte, CD3+ and CD4+ counts should receive added attention. |
|
33078012; Smell and taste in CoViD-19 patients: the forgotten sense |
Gamba, P, Zaniboni, et al |
Recenti progressi in medicina |
Long-Term Sequelae |
|
Determine whether COVID-19 positive patients with olfactory and gustatory dysfunction (n=73) have the ability to recover
from chemoreceptorial loss. Scores of the Olfactory Dysfunction Questionnaire CoViD-19 (QOD) recorded total recovery in all patients of olfactory and gustatory function with an average time of 17.4 days. |
|
Machine learning is the key to diagnose COVID-19: a proof of concept study |
Gangloff, Cedric, Rafi, et al |
Research Square prepub |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
536 patients were included in the study: 106 in the COVID group, 430 in the NOT-COVID group. AUC of chest-CT increased
from 0.778 to 0.889 with the contribution of machine learning. Similarly, AUC of RT-PCR increased from 0.852 to 0.929 with machine learning. The study finds, after generalization, machine learning models will allow for increase chest-CT and RT-PCR performances
to diagnose COVID-19. |
|
Comparing Nasopharyngeal and Bronchoalveolar Lavage SARS-CoV-2 Assays in Respiratory
Failure |
Gao, C, Cuttica, et al |
Am J Respir Crit Care Med |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We studied a series of critically-ill patients with clinical concern for COVID-19 who had nasopharyngeal (NP) and bronchoalveolar
lavage (BAL) PCR testing in order to determine NP and BAL test characteristics and accuracy. We retrospectively reviewed adult patients intubated for acute hypoxic respiratory failure with clinical concern for COVID-19 tested with both NP and BAL PCR assays
for SARS-CoV-2 RNA. We reviewed 123 patents intubated for acute hypoxemic respiratory failure and tested for SARS-CoV-2 with a BAL within 5 days following an NP test. The median duration between NP and BAL swab was 1 day (IQR 1-2.75 days). NP tests were run
on the following platforms: 52 Abbott ID NOW, 5 Becton-Dickinson, 28 Cepheid, 33 in-house, and 5 not listed. BAL tests were run on the following platforms: 0 Abbott ID NOW, 10 Becton-Dickinson, 84 Cepheid, 29 in-house. Median age was 63 (IQR 46 – 70) years,
and 39 (31.7%) were female. 78/123 (63.4%) of the patients ended up having COVID-19. In comparison to BAL, sensitivity of an NP assay was 88.6%, specificity 88.6%, positive predictive value 93.3%, negative predictive value 81.3%, and accuracy 88.6%.. In critically-ill
patients intubated for acute hypoxic respiratory failure, NP assays for SARS-CoV-2 RNA have good test characteristics and accuracy in comparison with BAL assays. NP specimens are less invasive, easier, and potentially safer to collect than BAL specimens, especially
in centers where bronchoscopy is not routinely performed for suspected COVID-19 patients. |
|
Remote fingerstick blood collection for SARS-CoV-2
antibody testing |
Garcia-Beltran, Wilfredo, Miller, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we present a method that enables large scale SARS-CoV-2 serological studies by combining self or office collection
of fingerpick blood with an FDA-approved dried blood spot collection device (Neoteryx Mitra®) with a high-throughput electrochemiluminescence-based SARS-CoV-2 total antibody assay (Roche Elecsys®) that is EUA approved for use on serum samples. Extracts of
dried blood from Neoteryx Mitra® devices acquired in a community seroprevalence study showed near identical sensitivity and specificity in detection of SARS-CoV-2 antibodies as compared to neat sera using predefined thresholds for each specimen type. |
|
PATTERNS of MENTAL HEALTH HOTLINE CALLS during and before PANDEMIC |
Gerasimova, AA |
Counseling Psychology and Psychotherapy |
Mental Health |
|
Article in Russian. The article compares calls to a mental health hotline from March 1 to April 17, 2020, with the
same period in 2019. Calls related to stress, anxiety, suicide, and abuse are considered. In 2020, compared with the same period in 2019, the following dynamics are noted: the number of calls concerning anxious conditions increased 2.5 times; calls about suicidal
acts appeared, the number of calls about self-harming behavior increased 2.5 times; the number of complaints on the topics of domestic, physical and sexual abuse increased almost 1.5 times. It is assumed that the results can be extrapolated and thus they reflect
the current psychological difficulties of people as a whole. |
|
Gerevini, AE, Maroldi, et al |
|
Clinical data| Données cliniques |
In this paper we present a study and a concrete tool based on machine learning to predict the prognosis of hospitalised
patients with Covid-19. Our machine learning models use ensembles of decision trees trained and tested using data from more than 2000 patients. An experimental evaluation of the models shows good performance in solving the addressed task. |
|
|
Ghati, N, Roy, et al |
Trials |
RCT |
OBJECTIVES: To assess the impact of adding statin (atorvastatin) and/or aspirin on clinical deterioration in patients
infected with SARS-CoV-2 who require hospitalisation. The safety of these drugs in COVID-19 patients will also be evaluated. TRIAL DESIGN: This is a single-centre, prospective, four-arm parallel design, open-label, randomized control trial. PARTICIPANTS: The
study will be conducted at National Cancer Institute (NCI), Jhajjar, Haryana, which is a part of All India Institute of Medical Sciences (AIIMS), New Delhi, and has been converted into a dedicated COVID-19 management centre since the outbreak of the pandemic.
All RT-PCR confirmed cases of SARS-CoV-2 infection with age ≥ 40 years and 5), documented significant liver disease/dysfunction (aspartate transaminase AST] / alanine aminotransferase ALT] > 240), myopathy and rhabdomyolysis (creatine phosphokinase CPK] >
5x normal), allergy or intolerance to statins or aspirin, prior statin or aspirin use within 30 days, history of active gastrointestinal bleeding in past three months, coagulopathy, thrombocytopenia (platelet count < 100000/ dl), pregnancy, active breastfeeding,
or inability to take oral or nasogastric medications will be excluded. Patients refusing to give written consent and taking drugs that are known to have a significant drug interaction with statin or aspirin including cyclosporine, HIV protease inhibitors,
hepatitis C protease inhibitor, telaprevir, fibric acid derivatives (gemfibrozil), niacin, azole antifungals (itraconazole, ketoconazole), clarithromycin and colchicine] will also be excluded from the trial. INTERVENTION AND COMPARATOR: In this study, the
benefit and safety of atorvastatin (statin) and/or aspirin as adjuvant therapy will be compared with the control group receiving usual care for management of COVID-19. Atorvastatin will be prescribed as 40 mg oral tablets once daily for ten days or until discharge,
whichever is earlier. The dose of aspirin will be 75 mg once daily for ten days or until discharge, whichever is earlier. All other therapies will be administered according to the institute's COVID-19 treatment protocol and the treating physician's clinical
judgment. MAIN OUTCOMES: All study participants will be prospectively followed up for ten days or until hospital discharge, whichever is longer for outcomes. The primary outcome will be clinical deterioration characterized by progression to WHO clinical improvement
ordinal score ≥ 6 (i.e., endotracheal intubation, non-invasive mechanical ventilation, pressor agents, renal replacement therapy, ECMO requirement, and mortality). The secondary outcomes will be change in serum inflammatory markers (C-reactive protein and
Interleukin-6), Troponin I, and creatine phosphokinase (CPK) from time zero to 5th day of study enrolment or 7th day after symptom onset, whichever is later. Other clinical outcomes that will be assessed include progression to Acute Respiratory Distress Syndrome
(ARDS), shock, ICU admission, length of ICU admission, length of hospital admission, and in-hospital mortality. Adverse drug effects like myalgia, myopathy, rhabdomyolysis, hepatotoxicity, and bleeding will also be examined in the trial to assess the safety
of the interventions. RANDOMISATION: The study will use a four-arm parallel-group design. A computer-generated permuted block randomization with mixed block size will be used to randomize the participants in a 1:1:1:1 ratio to group A (atorvastatin with conventional
therapy), group B (aspirin with conventional therapy), group C (aspirin + atorvastatin with conventional therapy), and group D (control; only conventional therapy). BLINDING (MASKING): The study will be an open-label trial. NUMBERS TO BE RANDOMISED (SAMPLE
SIZE): As there is no existing study that has evaluated the role of aspirin and atorvastatin in COVID-19 patients, formal sample size calculation has not been done. Patients satisfying the inclusion and exclusion criteria will be recruited during six months
of study period. Once the first 200 patients are included in each arm (i.e., total 800 patients), the final sample size calculation will be done on the basis of the interim analysis of the collected data. TRIAL STATUS: The institutional ethical committee has
approved the study protocol (Protocol version 3.0 June 2020]). Participant recruitment starting date: 28(th) July 2020 Participant recruitment ending date: 27(th) January 2021 Trial duration: 6 months TRIAL REGISTRATION: The trial has been prospectively registered
in Clinical Trial Registry - India (ICMR- NIMS): Reference no. CTRI/2020/07/026791 (registered on 25 July 2020)]. FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest of
expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. |
|
|
Gillett, G, Jordan, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
A previously fit and well 37-year-old male healthcare worker presented with confusion, psychotic symptoms and a suicide
attempt in the context of a new COVID-19 diagnosis. Following surgical interventions and an extended admission to the intensive care unit, he made a good recovery in terms of both his physical and mental health. A number of factors likely contributed to his
presentation, including SARS-CoV-2 infection, severe insomnia, worry, healthcare worker-related stress, and the unique social and psychological stressors associated with the COVID-19 pandemic. This case highlights the need to further characterise the specific
psychiatric sequelae of COVID-19 in community settings, and should remind general medical clinicians to be mindful of comorbid psychiatric symptoms when assessing patients with newly diagnosed COVID-19. |
|
|
Polyunsaturated ω-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding
and cellular entry |
Goc, Anna, Niedzwiecki, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
The study screened polyunsaturated fatty acids, monounsaturated fatty acids and saturated fatty acids, as wells as
lipid-soluble vitamins. In performing target-based ligand screening utilizing the RBD-SARS-CoV-2 sequence, the investigators observed that polyunsaturated fatty acids most effectively interfere with binding to hACE2, the receptor for SARS-CoV-2. Using a spike
protein pseudo-virus, they also found that linolenic acid and eicosapentaenoic acid significantly block the entry of SARS-CoV-2. |
|
Paediatric patients seen in 18 emergency departments during the COVID-19 pandemic |
Goldman, RD, Grafstein, et al |
Emerg Med J |
Healthcare Response | Réponse des soins de santé |
We sought to determine whether ED paediatric presentations prior and during the COVID-19 pandemic changed and review
acuity compared with seasonal adjusted prior year. METHODS: We analysed records from 18 EDs in British Columbia, Canada, serving 60% of the population. We compared prepandemic (before the first COVID-19 case), early pandemic (after first COVID-19 case) and
peak pandemic (during public health emergency) periods as well as a similar time from the previous year. RESULTS: A reduction of 57% and 70% in overall visits was recorded in the children's hospital ED and the general hospitals EDs, respectively. |
|
Goyal, M, Singh, et al |
Int J Gynaecol Obstet |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to assess the effects of the COVID-19 pandemic on obstetric care and outcomes. Although
COVID-19 disease does not directly affect pregnancy outcomes, it has indirect adverse effects on maternal and child health. |
|
|
GÜner, AE, MemİŞoĞlu, et al |
Turk J Med Sci |
Public health interventions*| Interventions de santé publique |
In this brief piece which is about the decision to shut down Grand Bazaar, a highly dense shopping area with 10.000
employees and 4000 individual shops after a week of the first confirmed case of COVID-19 in Turkey. We argue that this pre emptive action taken to shut down the shopping area, after symptoms screening of all individuals and PCR testing when necessary, have
limited transmission of COVID-19 in Istanbul. We make the cases that it is important for decision makers to take action swiftly in order to contain COVID-19 in dense areas and decisions should not wait a flare up of cases. |
|
|
COVI-AgentSim: an Agent-based Model for Evaluating Methods of Digital Contact Tracing |
Gupta, Prateek, Maharaj, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
We introduce an agent-based compartmental simulator we call COVI-AgentSim, integrating detailed consideration of virology,
disease progression, social contact networks, and mobility patterns, based on parameters derived from empirical research. Our results suggest any digital contact tracing method can help save lives, support re-opening of economies, and prevent second-wave
outbreaks, and that feature-based contact tracing methods are a promising direction for enriching binary contact tracing using self-reported symptoms, yielding earlier warning signals and a significantly reduced spread of the virus per socioeconomic cost. |
|
Psychological health among armed forces doctors during COVID-19 pandemic in India |
Gupta, S, Kohli, et al |
Indian Journal of Psychological Medicine |
Mental Health |
|
Authors studied the prevalence of anxiety and depressive symptoms among armed forces doctors in India during the COVID-19
pandemic and the factors that contribute to these symptoms. The study revealed a high prevalence of anxiety and depressive symptoms among armed forces doctors. |
|
Possible synergistic effect of air pollution on increasing severity of
SARS-CoV-2 |
Habibi, Laleh, Tannazi, et al |
|
Epidemiology| Épidémiologie |
In order to assess the possible synergistic effect of air pollution on the increased severity of COVID-19, the number
of days with unhealthy ranges were measured for three years in eight cities of Iran with different numbers of hospitalized patients affected with SARS-CoV-2. The present data revealed a significant positive correlation between unhealthy ranges of O3 and NO2
and the number of hospitalized patients with COVID-19. |
|
Lockdown measures in response to COVID-19 in nine sub-Saharan African countries |
Haider, N, Osman, et al |
BMJ Global Health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
This study proposed a definition of a lockdown' based on a two-by-two matrix that categorises different communicable
disease measures based on whether they are compulsory or voluntary; and whether they are targeted at identifiable individuals or facilities, or whether they are applied indiscriminately to a general population or area. Using this definition, described the
design, timing and implementation of lockdown measures in nine countries in sub-Saharan Africa: Ghana, Nigeria, South Africa, Sierra Leone, Sudan, Tanzania, Uganda, Zambia and Zimbabwe. While there were some commonalities in the implementation of lockdown
across these countries, a more notable finding was the variation in the design, timing and implementation of lockdown measures. Also found that the number of reported cases is heavily dependent on the number of tests carried out, and that testing rates ranged
from 2031 to 63 928 per million population up until 7 September 2020. The reported number of COVID-19 deaths per million population also varies (0.4 to 250 up until 7 September 2020), but is generally low when compared with countries in Europe and North America. |
|
Hakami, Z, Khanagar, et al |
J Dent Educ |
Mental Health |
|
The aim of this study was to assess the psychological impact of the pandemic on dental students in Saudi Arabia. Significant
differences in mental health outcomes were evident for gender, university, and survey time. Elevated levels of depression, anxiety, and stress were recorded among 60.64%, 37.02%, and 34.92%, respectively, of the students. Females, students who lived alone,
and junior students were more likely to experience psychological problems during the COVID‐19 pandemic. |
|
|
Hamadé, A, Woehl, et al |
Ann Hepatol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this work was to evaluate the incidence of aminotransferases disorders in patients infected with COVID-19
and to manage the VTE events associated with elevated. We report a retrospective study of 46 patients admitted for COVID-19 infection. Venous duplex ultrasound of lower limbs was performed in all patients at Day 0 and Day 5. Elevated AT were reported in 28
patients (61%). 10 had acute VTE events, of them 8 (17.4%) with aminotransferases disorders. They have been treated with curative Enoxaparin. With follow-up of 15 and or 30 days, six of them were controlled, and treated with direct oral anticoagulant (DOACs)
after normalization of aminotransferases. The incidence of aminotransferases disorders associated with acute VTE events in patients infected with COVID-19 is significant. The use of DOACs appear pertinent in these patients. Monitoring of the liver balance
should therefore be considered at a distance from the acute episode in the perspective of DOACs relay. |
|
|
Haque, Farzana, Lillie, et al |
Research Square prepub |
Clinical data| Données cliniques |
Report a case of a cancer patient with Lynch syndrome (hereditary nonpolyposis colorectal cancer, HNPCC) who manifested
SARS-COV-2 PCR (polymerase chain reaction) positivity for at least 54 days after contracting mild COVID-19 illness and propose that deficient mismatch repair (MMR) may have a role in the prolonged SARS-CoV-2 RNA shedding. |
|
|
Longitudinal monitoring of SARS-CoV-2 RNA on high-touch
surfaces in a community setting |
Harvey, AbigailP, Fuhrmeister, et al |
medRxiv |
Transmission |
We conducted longitudinal swab sampling of high-touch non-porous surfaces in a Massachusetts town during a COVID-19
outbreak from April to June 2020. Twenty-nine of 348 (8.3 %) surface samples were positive for SARS-CoV-2, including crosswalk buttons, trash can handles, and door handles of essential business entrances (grocery store, liquor store, bank, and gas station).
The estimated risk of infection from touching a contaminated surface was low (less than 5 in 10,000), suggesting fomites play a minimal role in SARS-CoV-2 community transmission. |
|
Imperfect innate immune antagonism renders SARS-CoV-2
vulnerable towards IFN-γ and -λ |
Hayn, Manuel, Hirschenberger, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
This study systematically assessed the impact of 29 SARS-CoV-2 proteins on viral sensing, type I, II and III interferon
(IFN) signaling, autophagy and inflammasome formation. Mechanistic analyses show that autophagy and type I IFN responses are effectively counteracted at different levels. For example, Nsp14 induces loss of the IFN receptor, whereas ORF3a disturbs autophagy
at the Golgi/endosome interface. Comparative analyses revealed that antagonism of type I IFN and autophagy is largely conserved, except that SARS-CoV-1 Nsp15 is more potent in counteracting type I IFN than its SARS-CoV-2 ortholog. Altogether, however, SARS-CoV-2
counteracts type I IFN responses and autophagy much more efficiently than type II and III IFN signaling. Consequently, the virus is relatively resistant against exogenous IFN-α/β and autophagy modulation but remains highly vulnerable towards IFN-γ and -λ treatment |
|
He, S, Tian, et al |
Frontiers in Pharmacology |
Epidemiology| Épidémiologie |
Authors discuss the situation where during the follow-up of patients recovered from COVID-19 in the quarantine and
observation period, some of the cured patients showed positive results again. The factors related to positive RT-PCR test results in observed subjects recovered from COVID-19 were age, comorbidity, and comprehensive intervention, among which comprehensive
intervention might be a protective factor. |
|
|
Heidarian, Shahin, Afshar, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper, a Capsule network framework, referred to as the "CT-CAPS", is presented to automatically extract distinctive
features of chest CT scans. These features, which are extracted from the layer before the final capsule layer, are then leveraged to differentiate COVID-19 from Non-COVID cases. The experiments on our in-house dataset of 307 patients show the state-of-the-art
performance with the accuracy of 90.8%, sensitivity of 94.5%, and specificity of 86.0%. |
|
|
Heidarian, Shahin, Afshar, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper, we propose a two-stage fully-automated CT-based framework for identification of COVID-19 positive cases
referred to as the "COVID-FACT". Based on our experiments, COVID-FACT achieves an accuracy of 90.82%, a sensitivity of 94.55%, a specificity of 86.04%, and an Area Under the Curve (AUC) of 0.98, while depending on far less supervision and annotation, in comparison
to its counterparts. |
|
|
Analysis of humoral immune responses in SARS-CoV-2 infected patients |
Henss, L, Scholz, et al |
J Infect Dis |
Clinical data| Données cliniques Immunology | Immunologie |
The humoral immune response of a cohort of 143 COVID-19 patients from the University Hospital Frankfurt/Main, Germany
was characterized. COVID-19 severity increased with age and male patients encountered more serious symptoms than females. Disease severity correlated with the amount of SARS-CoV-2 specific IgG and IgA and the neutralization activity of the antibodies. The
amount of SARS-CoV-2 specific IgG antibodies decreased with time after PCR conformation of the infection and antibodies directed against the nucleoprotein waned faster than spike directed antibodies. In contrast, for the common flu coronavirus NL63, COVID19
disease severity seemed to correlate with low NL63-neutralizing activities, suggesting the possibility of cross-reactive protection. |
|
Hindson, J |
Nat Rev Gastroenterol Hepatol |
Epidemiology| Épidémiologie |
756 patients with chronic liver disease (386 with cirrhosis and 359 without) from 29 countries were included. In patients
with chronic liver disease, risk factors for mortality were advancing age and alcohol-related liver disease. A propensity-score-matched analysis revealed an increased risk of mortality in patients with advanced cirrhosis (CTP-B and CTP-C) compared with a UK
cohort of 620 patients with SARS-CoV-2 infection but not chronic liver disease. |
|
|
Hirk, R, Kastner, et al |
Austrian Journal of Statistics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
Relying on the deCODE genetics study in Iceland, this study investigated the magnitude and uncertainty of the number
of undetected cases COVID-19 cases in Austria. Formulated several scenarios relying on data on the number of COVID-19 cases which have been hospitalized, in intensive care, as well as on the number of deaths and positive tests in Iceland and Austria. And employed
frequentist and Bayesian methods for estimating the dark figure in Austria based on the hypothesized scenarios and for accounting for the uncertainty surrounding this figure. Using data available on April 01, 2020, the two main findings are : First, found
the estimated number of infections to be on average around 8.35 times higher than the recorded number of infections. Second, the width of the uncertainty bounds associated with this figure depends highly on the statistical method employed. At a 95% level,
lower bounds range from 3.96 to 6.83 and upper bounds range from 9.82 to 12.61. Overall, the findings confirm the need for systematic tests in the general population of Austria. |
|
|
Hu, Yanmei, Ma, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Despite the weaker enzymatic inhibition of calpain inhibitors II and XII against Mpro compared to GC-376, calpain inhibitors
II and XII had more potent cellular antiviral activity. This research hypothesized that the cellular antiviral activity of calpain inhibitors II and XII might also involve the inhibition of cathepsin L in addition to Mpro. Tested calpain inhibitors II and
XII in the SARS-CoV-2 pseudovirus neutralization assay in Vero E6 cells and found that both compounds significantly decreased pseudoviral particle entry into cells, indicating their role in inhibiting cathepsin L. The involvement of cathepsin L was further
confirmed in the drug time-of-addition experiment. In addition, also found that these four compounds not only inhibit SARS-CoV-2, but also SARS-CoV, MERS-CoV, as well as human coronaviruses (CoVs) 229E, OC43, and NL63. |
|
|
Huy, Man Dinh Nguyen, My, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
Present the steps taken to prevent Lab associated infections related to SARS-CoV-2 testing in a tertiary care hospital
in Vietnam. |
|
|
Indartoyo, IM, Kim, et al |
|
Public Health response| Interventions de santé publique |
Companies must study the efforts made by buyers related to panic buying that is happening around them. The results
of a study of 647 posts on Twitter microblogging revealed that panic buying contained negative attitude. |
|
|
Ippolito, D, Ragusi, et al |
Eur Radiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
OBJECTIVES: To evaluate a semi-automated segmentation and ventilated lung quantification on chest computed tomography
(CT) to assess lung involvement in patients affected by SARS-CoV-2. METHODS: All images underwent quantitative analyses with a dedicated workstation using a semi-automatic lung segmentation software to compute ventilated lung volume (VLV), Ground-glass opacity
(GGO) volume (GGO-V), and consolidation volume (CONS-V) as absolute volume and as a percentage of total lung volume (TLV). RESULTS: GGO-V/TLV significantly correlated with WBC, neutrophils, platelets, CRP, PaCO(2), HCO(3)(-), and PaO2/FiO2 values. CONS-V/TLV
significantly correlated with WBC neutrophils, lymphocytes, CRP, PaCO(2), pH, HCO(3)(-), and P/Fvalues. Statistically significant differences between CONS-V, GGO-V, GGO-V/TLV, CONS-V/TLV, GGO-V/VLV, CONS-V/VLV, GGO-V + CONS-V/TLV, VLV/TLV, CT score, and invasive
ventilation by ET were found |
|
|
Clinical Conundrum: Dysphagia in a Patient with COVID-19 and Progressive Muscle
Weakness |
Ishkanian, A, Mehl, et al |
Dysphagia |
Long-Term Sequelae |
|
A 58-year-old woman with COVID-19 and a history of diabetes presented to an acute care hospital with 6 weeks of shortness
of breath, cough, and fatigue as well as a 2-week history of sudden onset of slurred speech, left upper extremity weakness, nausea/vomiting, and difficulty with ambulation. Due to a lack of improvement in swallow function at 3 weeks post-admission, a PEG was
placed. A repeat MBSS was performed at 8 weeks post-admission which showed moderate pharyngeal dysphagia with reduced pharyngeal residue and more effective use of compensatory strategies, such as repeat swallows. |
|
Islam, T, Mahmood, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
Using social media through mobile has become a major source of disseminating information; however, the motivations
that impact social media users’ intention and actual information-sharing behavior need further examination. To this backdrop, drawing on the uses and gratifications theory, theory of prosocial behavior, and theory of planned behavior, we aim to examine various
motivations toward information-sharing behaviors in a specific context coronavirus disease 2019 (COVID-19)]. We collected data from 388 knowledgeable workers through Google Forms and applied structural equation modeling to test the hypotheses. We noted that
individuals behave seriously toward crisis-related information, as they share COVID-19 information on WhatsApp not only to be entertained and seek status or information but also to help others. Further, we noted norms of reciprocation, habitual diversion,
and socialization as motivators that augment WhatsApp users’ positive attitude toward COVID-19 information-sharing behavior. © Copyright © 2020 Islam, Mahmood, Sadiq, Usman and Yousaf. |
|
|
Iwaya, GH, Cardoso, et al |
Revista de Administracao Publica |
Public Health response| Interventions de santé publique |
This research aimed to develop an Intention to Maintain Social Distancing Scale (IMSDS) based on the Theory of Planned
Behavior. The model establishes that the variables attitudes, subjective norms and perceived behavioral control are predictors of the intention to maintain social distancing. The methodological design was an online survey with non-probabilistic sampling. The
survey included 786 Brazilian participants. The Theory of Planned Behaviour variables explained 85% of the intention to maintain social distancing variation. |
|
|
Adjusting RT-qPCR conditions to avoid unspecific amplification in SARS-CoV-2 diagnostic |
Jaeger, LH, Nascimento, et al |
Int J Infect Dis |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here we report dimer formation in the N2 primers-probe set (CDC 2019-nCoV Real-Time RT-PCR) used in diagnostic routine,
and propose alternatives to reduce dimerization events. Late unspecific amplifications were visualized in 56.4% and 57.1% of negative samples and no-template control, respectively, but not in positive samples and positive control. The RT-qPCR parameters were
optimized and the late unspecific amplifications decreased to 11.5% in negative samples and no-template control. |
|
Benchmarking virus concentration methods for quantification of SARS-CoV-2
in raw wastewater |
Jafferali, MH, Khatami, et al |
Science of the Total Environment |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We collected wastewater from two European cities during the Covid-19 pandemic and evaluated the sensitivity of RT-qPCR
detection of viral RNA after four concentration methods. Further, we evaluated one external (bovine corona virus) and one internal (pepper mild mottle virus) reference virus. We found a consistently higher recovery of spiked virus using the modified ultrafiltration-based
method. This method also had a significantly higher efficiency for wastewater SARS-CoV-2 detection. The ultracentrifugation method was the only method that detected SARS-CoV-2 in the wastewater of both cities. |
|
Intersection of the Web-Based Vaping Narrative With COVID-19: Topic Modeling Study |
Janmohamed, K, Soale, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
Our main finding is the emergence of a vape-administered CBD treatment narrative around COVID-19 when comparing the
web-based vaping narratives before and during the COVID-19 pandemic. These results are key to understanding how vapers respond to inaccurate information about COVID-19, optimizing treatment of vapers who contract COVID-19, and possibly minimizing instances
of inaccurate information. The findings have implications for the management of COVID-19 among vapers and the monitoring of web-based content pertinent to tobacco to develop targeted interventions to manage COVID-19 among vapers. |
|
An sihr epidemic model of the covid-19 with general population-size dependent contact
rate |
Jiao, S, Huang, et al |
AIMS Mathematics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, we propose an SIHR model that predicts the course of the epidemic to help plan an effective control
strategy. The values of parameters in the model are estimated on the basis of fitting to the reported data of COVID-19 from February 5 to March 17, 2020, in Hubei province. The results showed that (i) the peak of total confirmed cases will arrive around late
February of 2020, (ii) the cumulative number of confirmed cases to be around 68,000 cases, (iii) the disease will end in mid-May of 2020. All these findings are consistent with the actual situation of Hubei province. Based on the empirical results, it is recommended
to strengthen community closures and increase medical resources, which is the key to controlling the spread of COVID-19 in Hubei province. |
|
Jo, Wonkwang, Chang, et al |
Research Square prepub |
Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions
de sant&eacute; publique |
Using contact tracing information of 3,283 confirmed patients in Seoul metropolitan areas from Jan 20 to July 19, 2020,
the study creates an infection network and analyzes its structural characteristics. The main results are as follows: (1) out-degrees follow an extremely positively skewed distribution, and (2) removing the top nodes on the out-degree significantly decreases
the size of the infection network. (3) The indicators, which express the infectious power of the network, change according to governmental measures. |
|
|
Joharry, SA, Turiman, et al |
GEMA Online Journal of Language Studies |
Public Health response| Interventions de santé publique |
In this paper, authors explore how citizens in Malaysia respond to such crises by examining letters that were submitted
during the MCO period to The Star Online – the nation’s leading English online news portal. Results yield Malaysians’ view on the matter that could describe in so far as how the country is coping with the pandemic at the time. |
|
|
Prognostic value of troponin-t and b-type natriuretic peptide in patients hospitalized
for covid-19 |
Junior, GLGA, Braga, et al |
Arquivos Brasileiros de Cardiologia |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To evaluate the prognostic value of Troponin-T (TNT) and natriuretic peptide (BNP) in patients hospitalized for Covid-19.
Data were collected from medical records to assess the association of TnT and BNP measured in the first 24 hours of hospital admission with the combined outcome (CO) of death or need for mechanical ventilation. We evaluated 183 patients (age = 66.8±17 years,
65.6% of which were males). The time of follow-up was 7 days (range 1 to 39 days). The CO occurred in 24% of the patients. The median troponin-T and BNP levels were 0.011 and 0.041ng/dL (p <0.001); 64 and 198 pg/dL (p <0.001), respectively, for the groups
without and with the CO. In the univariate analysis, in addition to TnT and BNP, age, presence of coronary disease, oxygen saturation, lymphocytes, D-dimer, t-CRP and creatinine, were different between groups with and without outcomes. In the bootstrap multivariate
analysis, only TnT (1.12 95% CI 1.03-1.47]) and t-CRP (1.04 95% CI 1.00-1.10]) were independent predictors of the CO. |
|
Kabir, KMA, Tanimoto, et al |
Royal Society Open Science |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique Economics | Économie |
This paper combines compartmental epidemiological models with the concept of behavioural dynamics from evolutionary
game theory (EGT). This innovation allows us to model how compliance with an economic lockdown might wane over time, as individuals weigh the risk of infection against the certainty of the economic cost of staying at home. Numerical analysis of our model suggests
that emergency-relief funds spent at the individual level are effective in reducing the duration and overall economic cost of a pandemic. We also find that shield immunity takes hold in a population most easily when a lockdown is enacted with relatively low
costs to the individual. |
|
|
Kadhem, SJ, Raheem, et al |
Systematic Reviews in Pharmacy |
Clinical data| Données cliniques |
The COVID 19 is a recent condition due to the coronavirus sar-cov2 which started in Wuhan at December 2019 and spread
all over the word to cause one of the most serious pandemic in the human history as it declare by the WHO as pandemic on February 2020. 78 patients with the confirmation of COVID 19 were included (done by PCR of both nasopharyngeal & oropharyngeal swabs or
by non-contrast chest CT, for all the platelets count were done at admission & on discharge & to see the relation with age, stay in hospital, days for symptoms resolution, RCU need & death, the results show that the platelets increment show more in discharge
patients with mean features of recovery in both CT & PCR +ve patients but not predict mortality or need for RCU admission. © 2020 EManuscript Technologies. All rights reserved. |
|
|
Supercomputing-supported COVID-19 CT image comprehensive analysis assistant system |
Kang, B, Guo, et al |
Journal of Image and Graphics |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
A supercomputing-supported method is proposed for the construction of a new comprehensive CT analysis auxiliary system
dealing with pneumonia. After its release, the system has continuously and steadily provided new COVID-19 auxiliary diagnostic services and scientific research support for more than 30 hospitals and more than 100 scientific research institutions at home and
abroad, providing important support for combating the epidemic. |
|
Reported Change in Adolescent Psychosocial Functioning during the Covid-19
Outbreak |
Kapetanovic, Sabina, Gurdal, et al |
Research Square prepub |
Mental Health |
|
Described adolescents’ thoughts and behaviors, as well as perceived changes in substance use, everyday life, relations,
victimization, and mental health during the COVID-19 outbreak, in Sweden. Results show that a) adolescents tend to comply with regulations from the government, b) although most adolescents do not experience psychosocial changes, a critical number report increase
in substance use and negative relational changes and c) most of the adolescents report poorer control of their everyday life and mental health. Adolescent females and adolescents with distance schooling were likely to report negative changes in their psychosocial
functioning during the Covid-19 outbreak |
|
Kapoor, D, Perwaiz, et al |
Indian Journal of Surgery |
Healthcare Response | Réponse des soins de santé |
This is a case series analysis of elective gastro-intestinal surgical procedures performed from March 24, 2020, to
July 31, 2020. During this period, 314 gastro-intestinal surgical procedures were performed; of which, 45% were for malignancies. Major postoperative complications (Clavien-Dindo grade 3 and above) were witnessed in 3.5% (11/314) patients, with no statistically
significant difference when compared with the rate of major complications last year (45/914, 4.9% vs 11/314, 3.5%, p = 0.3). The 30-day mortality rate was 1% (n = 3). No patient developed COVID in the postoperative period. With preventive and screening strategies
and proper patient selection, it is possible to deliver safe GI surgical services during the COVID pandemic, without increasing the risk for major postoperative complications. |
|
|
Khaja, M, Gomez, et al |
Am J Case Rep |
Clinical data| Données cliniques |
This case report is of a patient who presented with loss of taste and facial weakness and was diagnosed with Guillain-Barre
syndrome (GBS) and Bell's palsy, associated with SARS-CoV-2 infection. The patient responded to intravenous immunoglobulin (IVIG) treatment. Our case is rare because the patient did not present with lower extremity weakness, but only with bilateral Bell's
palsy. Physicians should be aware of GBS because it is a neurological emergency for which COVID-19 can be a risk factor. Early diagnosis and treatment of GBS can prevent neurological disability. |
|
|
32946369; Transmission of SARS-CoV 2 During Long-Haul Flight |
Khanh, NC, Thai, et al |
Emerging infectious diseases |
Epidemiology| Épidémiologie Transmission |
To assess the role of in-flight transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we investigated
a cluster of cases among passengers on a 10-hour commercial flight. We traced 217 passengers and crew to their final destinations and interviewed, tested, and quarantined them. Among the 16 persons in whom SARS-CoV-2 infection was detected, 12 (75%) were passengers
seated in business class along with the only symptomatic person (attack rate 62%). Seating proximity was strongly associated with increased infection risk (risk ratio 7.3, 95% CI 1.2-46.2). We found no strong evidence supporting alternative transmission scenarios.
In-flight transmission that probably originated from 1 symptomatic passenger. |
|
Kienle, Gunver, Werthmann, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
The ENTAIER trial investigates the influence of mindful movements on fall risk, fear of falling, mobility, balance,
quality of life, and other outcomes. After the trial began, COVID-19 lock-downs stopped all in-person meetings, and it was expected that the limitations of this pandemic would continue long term. Therefore, the exercise program, which involve complex movements
and is typically conducted face-to-face in groups, had to be substituted by a telemedicine program within a short timeframe. The objectives, therefore, were to identify challenges and tasks that need to be resolved and steps that need to be taken to achieve
high-quality, efficacy, safety, and enable human encounter and motivation. |
|
|
Social Isolation and Psychological Distress During the COVID-19 Pandemic: A Cross-National
Analysis |
Kim, HH, Jung, et al |
Gerontologist |
Mental Health |
|
This study investigates the link between social isolation and mental well-being in later life, and how it varies across
countries. This study shows that a proper understanding of the impact of COVID-19 on the mental well-being of older adults should consider the moderating role of national context. |
|
Telephone based Interventions for Psychological Problems in Hospital Isolated Patients
with COVID-19 |
Kim, JW, Stewart, et al |
Clin Psychopharmacol Neurosci |
Clinical data| Données cliniques Mental Health |
|
We investigated the feasibility and effectiveness of telephone based interventions for psychological problems in hospital
isolated patients with COVID-19. Of 33 enrolled, clinically meaningful psychological symptoms were found in 6 (18%) patients for anxiety; 13 (39%) for depression; 10 (30%) for insomnia; and 3 (9%) for suicidal ideation. In 9 patients (27%), psychotropic medications
were prescribed to manage anxiety, agitation, depressed mood, insomnia, impulsivity, and suicide idea. Compared to baseline, significant improvements were found in anxiety, depression, and suicidal ideation at one week. There were no statistical differences
between the values evaluated at baseline and at two weeks. |
|
Kim, T, Roslin, et al |
Obesity (Silver Spring) |
Epidemiology| Épidémiologie |
We examine the association between body mass indexes (BMI) and clinical outcomes among patients with COVID‐19 infection.
We included 10,861 patients with COVID‐19 infection admitted to the Northwell Health system hospitals during the period of March 1 to April 27, 2020. Patients who are underweight or with obesity are at a risk for mechanical ventilation and death, suggesting
pulmonary complications (indicated by IMV) is a significant contributor for poor outcomes in COVID‐19 infection. |
|
|
Kocayiğit, H, Özmen Süner, et al |
J Clin Pharm Ther |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The aim of this study was to describe the clinical experience with FPV and LPV/r in critically ill patients with COVID‐19
(n=107) at Sakarya University Education and Research Hospital. 65 patients received FPV (Group FPV) and 42 received LPV/r (Group LPV/r). The two groups were similar in terms of demographic data and clinical findings. 43 (66.2%) of the 65 patients in the FPV
group and 23 (54.8%) of the 42 patients in the LPV/r group died (p = 0.237). The median ICU stay was 6.6 (IQR, 3–10) days in the FPV group and 9 (IQR, 6–16) days in the LPV/r group, which was a statistically significant difference (p = 0.010). |
|
|
Koley, Tirthankar, Madaan, et al |
Research Square prepub |
Coronavirology| Coronavirologie zoonoses |
Performed a comparative protein-protein docking analysis using the crystal structure of spike protein and homology
models of the ACE2 receptor from 16 commonly found mammalian species to understand the potential mode of spike binding. The analysis revealed the natural substitution of amino acid residues Gln24, His34, Phe40 and Met82 in the N-terminal α1 and α2 helices
results in loss of crucial network of hydrogen-bonded and hydrophobic interactions with spike 2 RBD domain. Besides, the absence of N-linked glycosylation site Asn103 in other mammals further reduces the binding affinity between spike and ACE2 receptor. These
changes explain the differences in the susceptibility and host pathogenesis in other mammalian species. |
|
|
Korecka, N, Rabenstein, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
The current cross-sectional study investigated influencing factors on: (i) the comparability of psychotherapy via internet/telephone
with psychotherapy in face-to-face contact as well as (ii) the actual experience with psychotherapy via internet/telephone compared to respective prior expectations in CBT therapists for German or Austrian therapists (n = 190). Implications of the results
are that attitudes towards remote psychotherapy might be increased in CBT therapists when they treat more patients remotely and experiences with remote psychotherapies should be included in psychotherapy training. |
|
|
Kowalska, Justyna Dominika, Kase, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In statistical analyses characteristics of HIV-positive patients asymptomatic/moderate and moderate/severe course were
compared. In total 34 HIV-positive patients diagnosed with COVID-19 were reported by 12 countries. Asymptomatic courses of COVID-19 were reported in four (12%) cases, 11 (32%) patients presented with mild disease not requiring hospitalization, moderate disease
with respiratory and/or systemic symptoms was observed in 14 (41%) cases, and severe disease with respiratory failure was found in five (15%) patients. The only HIV-related characteristics differentiating a moderate/severe course of the disease from asymptomatic/mild
disease course was the use of or PI or NNRTI as part of the cART regimen (40.0% vs. 5.3%, p=0.0129 for PI and 31.6 % vs. 0.0%, p= 0.0239 for NNRTI ). |
|
|
Immunological imprint of COVID-19 on human peripheral blood leukocyte populations |
Kratzer, B, Trapin, et al |
Allergy |
Clinical data| Données cliniques Immunology | Immunologie |
We used multiparametric flow cytometry to analyze whole peripheral blood samples, and determined SARS-CoV-2 specific
antibody levels against the S-protein, its RBD-subunit and viral nucleocapsid in a cohort of COVID-19 convalescent patients who had mild disease approximately 10 weeks after infection (n=109) and healthy control subjects (n=98). Even ten weeks after disease
COVID-19 convalescent patients had fewer neutrophils, while their cytotoxic CD8(+) T cells were activated, reflected as higher HLA-DR and CD38 expression. Multiparametric regression analyses showed that in COVID-19 patients both CD3(+) CD4(+) and CD3(+) CD8(+)
effector memory cells were higher, while CD25(+) Foxp3(+) T regulatory cells were lower. In addition, both transitional B cell and plasmablast levels were significantly elevated in COVID-19 patients. Fever (duration, level) correlated with numbers of central
memory CD4(+) T cells and anti-S and anti-RBD, but not anti-NC antibody levels. Moreover, a "young immunological age" as determined by numbers of CD3(+) CD45RA(+) CD62L(+) CD31(+) recent thymic emigrants was associated with a loss of sense of taste and/or
smell. |
|
Kristina, SA, Herliana, et al |
International Journal of Pharmaceutical Research |
Healthcare Response | Réponse des soins de santé |
The objective of this cross=sectional survey study was to explore the role and responsibilities of pharmacists during
the pandemic in Indonesia (n=320). The information source most commonly used by pharmacists was social media (72.19%). Pharmacists were mostly effective at handling patient care and medication supply. The perception of the role of a pharmacist was more significant
among males, hospital pharmacists, and pharmacists who have served for 5 years or more. The functions of a pharmacist in doing patient care and supporting infection prevention was more significant to male pharmacists, pharmacists employed in hospitals, pharmacists
employed for 5 years or more, and pharmacists attending 3 or more coronavirus workshops. Finally, the understanding of a pharmacist's role in managing drug supply was higher to the community of pharmacists aged 35-55, pharmacists working in hospitals, and
pharmacists who have worked for 5 years or more. |
|
|
Kuchay, MS, Reddy, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Clinical data| Données cliniques |
Three patients (data of two patients already published) with acute onset diabetes and DKA, precipitated by coronavirus
disease 2019 (COVID-19), were followed for 14 weeks to assess the behavior of the diabetes. Three individuals developed symptoms suggestive of SARS CoV-2 infection. After a few days, they were detected to have COVID-19 pneumonia, based on reverse transcription-polymerase
chain reaction (RT-PCR) assay and chest imaging. In the meantime, they also developed acute onset diabetes and DKA, which were precipitated by COVID-19. |
|
|
Kudo, E, Israelow, et al |
PLoS Biology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
To simplify testing and reduce the volume of required reagents, we devised a multiplex RT-qPCR assay to detect SARS-CoV-2
in a single reaction. We used existing N1, N2, and RP primer and probe sets by the Centers for Disease Control and Prevention, but substituted fluorophores to allow multiplexing of the assay. Low copy numbers (≥500 copies/reaction) of SARS-CoV-2 RNA were consistently
detected by the multiplex RT-qPCR. Our novel multiplex RT-qPCR improves upon current single diagnostics by saving reagents, costs, time, and labor. |
|
|
Kumar, Amit, Kumar, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study used protein-protein docking in order to understand the interaction of membrane protein's interaction with
envelope, spike and nucleocapsid proteins. Further, simulation studies performed up to 100ns agreed that protein complexes M-E, M-S, and M-N were stable. Moreover, the calculated free binding energy and dissociation constant values support the protein complex
formation. The interaction identified in the study will be of great importance, as it provides valuable insight into the protein complex, which could be the potential drug targets for future studies. |
|
|
Lan, FY, Suharlim, et al |
Occup Environ Med |
Epidemiology| Épidémiologie Mental Health |
|
We investigate SARS-CoV-2 (the virus causing COVID-19) infection and exposure risks among grocery retail workers, and
to investigate their mental health state during the pandemic. In this single store sample, we found a considerable asymptomatic SARS-CoV-2 infection rate among grocery workers. Employees with direct customer exposure were five times more likely to test positive
for SARS-CoV-2. Those able to practice social distancing consistently at work had significantly lower risk of anxiety or depression. |
|
|
Covid-19 pandemic and death anxiety in security forces in spain |
Lázaro-Pérez, C, Martínez-López, et al |
International Journal of Environmental Research and Public Health |
Mental Health |
|
The following investigation is developed based on two objectives: (PO1) to know the level of anxiety in the face of
death of State Security Forces and the Armed Forces ; (PO2) to determine the predictive variables in the above-mentioned phenomenon. Professionals from all over Spain have participated in the study (n = 2079). The results show a total level of 69.2% in the
scale, as well as some higher levels about the fear of death of others (82.1%) and the fear of the process of dying of others (78.2%). On the other hand, from the binary logistic regressions, four variables are evidenced that condition the risk of suffering
death anxiety: (a) certainty of needing psychological treatment in the future; (b) absence of Individual Protection Equipment (PPE); (c) high levels of Emotional Exhaustion; (d) high levels of depersonalization—these last two come from the Maslach and Jackson
Burnout scale. |
|
Li, Andrew |
SSRN- Lancet prepublication |
Public health interventions*| Interventions de sant&eacute; publique |
As cases of the coronavirus disease (COVID-19) soar worldwide, contact tracing has proven to be an essential and effective
method of slowing the virus propagation. This paper explores the feasibility of an automatic contact tracing technology that uses Bluetooth signals to determine proximity between two devices. While without obstruction Bluetooth signal strength is effective
at proximity sensing, obstructions and variations in device orientation provide sufficient ambiguity such that Bluetooth signal strength alone cannot reliably determine proximity. It is also found that the duration of contact can be accurately measured by
the number of transmissions received. More factors other than signal strength, such as those accounting for suboptimal conditions, must be considered to reliably determine proximity. |
|
|
A SARS-CoV-2 Microscopic Image Dataset with Ground Truth Images and Visual Features |
Li, C, Zhang, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
SARS-CoV-2 has characteristics of wide contagion and quick propagation velocity. To analyse the visual information
of it, we build a SARS-CoV-2 Microscopic Image Dataset (SC2-MID) with 48 electron microscopic images and also prepare their ground truth images. Furthermore, we extract multiple classical features and novel deep learning features to describe the visual information
of SARS-CoV-2. Finally, it is proved that the visual features of the SARS-CoV-2 images which are observed under the electron microscopic can be extracted and analysed. © 2020, Springer Nature Switzerland AG. |
|
Li, HY, Wang, et al |
Medicine (Baltimore) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We determined the correlations of patient parameters with disease severity in patients with COVID-19. The main clinical
symptoms of patients from Wuhan who had COVID-19 were fever and cough. Patients with severe/critical disease were more likely to be male and elderly. Disease severity correlated with increased leukocytes, CRP, PCT, BNP, D-dimer, liver enzymes, and myocardial
enzymes, and with decreased lymphocytes and blood oxygen partial pressure. |
|
|
COVID-19 and Psoriasis: Recommendation for Patients on Regular Infliximab Therapy |
Li, S, Zhang, et al |
Dermatol Ther |
Healthcare Response | Réponse des soins de santé |
During COVID-19 outbreak hospitals were congested and infliximab was interrupted. Thus, we performed this observational
study to understand the consequent burden of complications in these special cluster of psoriatic patients. We followed up fifty-six psoriatic patients who were receiving Infliximab treatment by telephone. The majority of patients had lesions exacerbation，accompanied
by anxiety emotion. It is suggested that reserving common drugs for psoriasis at home is necessary. Besides, telemedicine should be advocated as a main medical visit mode during the outbreak of COVID-19. This article is protected by copyright. All rights reserved. |
|
Lima, ARO, Cardoso, et al |
J Pediatric Infect Dis Soc |
Clinical data| Données cliniques |
This report, briefly, informs about the case of a 27-year-old woman admitted to the hospital at 32 weeks of gestation
with SARS-CoV-2 infection. We describe for the first time in the literature a case of fetal pericarditis due to SARS-CoV-2 maternal transmission, accompanied by systemic inflammatory profile. |
|
|
Lin, YH, Luo, et al |
Medicine (Baltimore) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to explore the clinical features of patients with COVID-19 and compared them with those of hospitalized community-acquired
pneumonia (CAP) patients caused by influenza virus during the same period. A total of 35 COVID-19 patients and 22 CAP patients caused by influenza virus were included in this study. Most of COVID-19 patients had characteristics of familial clustering (63%),
however, in the other group, there was no similar finding. The percentages of patients with a high fever (the highest recorded temperature was ≥39.0°C; 11% vs 45% [COVID-19 vs CAP groups, respectively]), dyspnea (9% vs 59%), leukocytosis (3% vs 32%), elevated
C-reactive protein concentrations (>10 mg/L, 48% vs 86%), elevated procalcitonin levels (>0.1 ng/ml, 15% vs 73%), PaO2/FiO2 <200 mm Hg (4% vs 22%), and infiltration on imaging (29% vs 68%) in the COVID-19 group were less than those same indices in the hospitalized
CAP patients caused by influenza virus. Ground-glass opacity with reticular pattern (63%) and interlobular septal thickening (71%) in chest CT were commonly observed in the COVID-19 group. |
|
|
Towards a Realistic Model for Simulating Spread of Infectious COVID-19 Disease |
Liu, XX, Fong, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The contribution presented in this paper is a new model called SEAIRD which caters for the new characteristics of the
2019-nCoV, therefore applicable for the inclusion of asymptomatic population in the simulation. |
|
Loey, M, Manogaran, et al |
Neural Computing and Applications |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this study, five different deep convolutional neural network-based models (AlexNet, VGGNet16, VGGNet19, GoogleNet,
and ResNet50) have been selected for the investigation to detect the Coronavirus-infected patient using chest CT radiographs digital images. The classical data augmentations along with CGAN improve the performance of classification in all selected deep transfer
models. The outcomes show that ResNet50 is the most appropriate deep learning model to detect the COVID-19 from limited chest CT dataset using the classical data augmentation with testing accuracy of 82.91%, sensitivity 77.66%, and specificity of 87.62%. |
|
|
M, P, Reddy, et al |
Eur J Pharmacol |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Herein, we selected transmembrane protease serine 2 (TMPRSS2) enzyme, a potential pharmacological target against SARS-CoV-2,
involved in the spread and pathogenesis of the virus. Validation of the modelled TMPRSS2 using various online tools confirmed model accuracy, topology and stereochemical plausibility. The results revealed eight potential drug candidates, namely nafamostat,
meloxicam, ganodermanontriol, columbin, myricetin, proanthocyanidin A2, jatrorrhizine and baicalein, which were further studied for ADME/T properties |
|
|
Maizlin, NN, Ohorodnyk, et al |
Journal of Medical Imaging and Radiation Sciences |
Healthcare Response | Réponse des soins de santé |
A questionnaire was created and distributed to the managers of eighteen outpatient DI clinics in London, Hamilton,
and Halton, Ontario, Canada. Findings show 50% percent of the DI clinics surveyed (9/18) closed as a result of COVID-19, and those that remained open had decreased hours of operation. The clinics that closed indicated decreased referrals as the primary reason
for closure, followed by staff shortage, concerns for safety, and suspension of elective imaging. Chest radiography and obstetric ultrasound were the most commonly conducted examinations. Clinics that were in close geographical proximity were able to redistribute
imaging examinations amongst themselves. All DI clinics had suspended BMD examinations and elective breast screening, and some transitioned to booked appointments only. |
|
|
ARIMA models for predicting the end of COVID-19 pandemic and the risk of second
rebound |
Malki, Z, Atlam, et al |
Neural Computing and Applications |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
In this work, we developed a predictive model that can estimate the expected period that the virus can be stopped and
the risk of the second rebound of COVID-19 pandemic. Based on the experimental results and simulation, the most striking finding is that the proposed algorithm shows the expected COVID-19 infections for the top countries of the highest number of confirmed
cases will be manifested between Dec-2020 and Apr-2021. Moreover, our study forecasts that there may be a second rebound of the pandemic in a year time if the currently taken precautions are eased completely. |
|
Mallow, PeterJ |
medRxiv |
Economics | Économie |
The economic burden of mortality due to the novel coronavirus (COVID-19) was estimated for the State of Ohio. Data
from the Ohio Department of Public Health and Social Security Administration was used to estimate the years of potential life lost, 56,518, and economic value of those lost lives, $13.60 billion. |
|
|
Stochastic Filtrate of Essential Workers to Reactivate the World Economy Safely |
Manjarrez, E, Olmos, et al |
Frontiers in Physics |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
Because there is a rapidly emerging risk that essential supply chains could collapse during the COVID-19 pandemic,
new strategies are urgently needed by governments to protect workers regardless of whether or not they have symptoms. We propose a “stochastic filtrate” of such workers to reduce the risk of physical interactions with workers infected with SARS-CoV-2. Here,
we suggest the random real-time-RT-PCR test of SARS-CoV-2 as a filtrating agent, although other more useful tests developed in the future to detect SARS-CoV-2 could also be used instead. Such a focused strategy, when combined with other preventive measures,
could be successfully replicated in many countries to reactivate the world's economy safely. Our stochastic filtrate concept includes a mathematical framework and conceptual model. The simulations of this stochastic filtrate process support its viability.
© Copyright © 2020 Manjarrez, Olmos, Cedillo and Salazar-Ibarguen. |
|
New ct finding (The target sign) in three patients
with covid-19 pneumonia |
Martins, RR, Santana, et al |
Jornal Brasileiro de Pneumologia |
Clinical data| Données cliniques |
In three RT-PCR–confirmed COVID-19 patients undergoing HRCT at our facility, ground-glass opacities or peripheral curvilinear
consolidative opacities were found |
|
Mastrangelo, A, Germinario, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We compared the incidence and characteristics of candidemia in a prospective cohort of patients with SARS-CoV-2 infection
to those of a historical cohort of nonCOVID-19 controls. Incidence rate of candidemia was significantly higher in patients with COVID-19 (10.97 [6.79 – 16.76] vs. 1.48 [1.10 – 1.95] cases per 10.000-PDFU. P-value <0.001). We found no imbalance in several predisposing
risk factors for candidemia, with the notable exception of a higher proportion of subjects in ICU and on immunosuppressive agents in the COVID-19 cohort |
|
|
Mayfield, CA, Sparling, et al |
J Community Health |
Public health interventions*| Interventions de sant&eacute; publique Public Health
response| Interventions de santé publique |
The purpose of our study was to describe and evaluate a Patient Engagement Messaging campaign (PEM campaign) promoting
health care seeking behaviors among community and rural clinic patients in North Carolina. Successful delivery was lower among Black patients and higher among patients with moderate health-risk comorbidities. Among the sample, 7.4% called the ROC-line, with
higher odds of calling among minority patients (vs. White) and among Medicaid and uninsured (vs. private insurance). Calling the ROC-line was associated with higher odds of scheduling any health care appointment (OR: 4.14; 95% CI 2.93–5.80) and receiving a
COVID-19 test (OR: 2.39; 95% CI 1.64–3.39). Messaging campaigns may help disconnected patients access health care resources and reduce disparities, but are likely still limited by existing barriers. |
|
|
PRAK-03202: A triple antigen VLP vaccine candidate
against SARS CoV-2 |
Mazumder, Saumyabrata, Rastogi, et al |
bioRxiv |
Clinical data| Données cliniques Vaccine Research| Recherche sur les vaccins Immunology
| Immunologie Animal model | Modèle animal |
This research developed PRAK−03202, the world′s first triple antigen VLP vaccine candidate in a highly characterized
S. cerevisiae−based D−Crypt™ platform, which induced SARS CoV−2 specific neutralizing antibodies in BALB/c mice. Immunizations using three different doses of PRAK−03202 induces antigen specific (Spike, envelope and membrane proteins) humoral response and neutralizing
potential. PBMCs from convalescent patients, when exposed to PRAK−03202, showed lymphocyte proliferation and elevated IFN-γ levels suggestive of conservation of epitopes and induction of T helper 1 (Th1)−biased cellular immune responses. These data support
the clinical development and testing of PRAK−03202 for use in humans. |
|
Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19 |
Meckiff, BJ, Ramírez-Suástegui, et al |
Cell |
Clinical data| Données cliniques Immunology | Immunologie |
Here, we present single-cell transcriptomic analysis of >100,000 viral antigen-reactive CD4+ T cells from 40 COVID-19
patients. In hospitalized patients compared to non-hospitalized patients, we found increased proportions of cytotoxic follicular helper cells and cytotoxic T helper (TH) cells (CD4-CTLs) responding to SARS-CoV-2 and reduced proportion of SARS-CoV-2-reactive
regulatory T cells (TREG). Importantly, in hospitalized COVID-19 patients, a strong cytotoxic TFH response was observed early in the illness, which correlated negatively with antibody levels to SARS-CoV-2 spike protein. Polyfunctional TH1 and TH17 cell subsets
were underrepresented in the repertoire of SARS-CoV-2-reactive CD4+ T cells compared to influenza-reactive CD4+ T cells. Together, our analyses provide insights into the gene expression patterns of SARS-CoV-2-reactive CD4+ T cells in distinct disease severities.
Analyses of CD4+ T cells from 40 COVID-19 patients show that hospitalization is associated with increased cytotoxic follicular helper cells and cytotoxic T helper cells and a reduction in regulatory T cells. |
|
Statistical Literacy Affects Risk Perceptions and Behaviors during
the COVID-19 Pandemic |
Metzger, Daniel, Paaso, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
Statistical literacy affects the interpretations of COVID-19-related information, assessments of infection risk, and
hence the compliance with mobility restrictions. Using a large-scale panel survey of about 4,000 Dutch households, we find that more statistically literate people assess the health risks related to the virus differently. Their estimates of the probability
of infection are significantly more sensitive to the current number of confirmed COVID-19 cases in their home province, both cross-sectionally at a given point in time as well as within the same individual over time. This evidence suggests that more statistically
literate people adjust their risk estimates more strongly to the actual infection risk. Similar to risk estimates, the social distancing behavior of more statistically literate people is more sensitive to the local situation. They are also generally more likely
to socially distance, less concerned about their own infection risk, and more concerned about infecting others, especially vulnerable populations such as the elderly. Using historical survey answers, we find that more statistically literate people generally
consider flu shot more important, potentially suggesting a more positive attitude toward vaccines. |
|
Meybodi, KT, Habibi, et al |
Childs Nerv Syst |
Healthcare Response | Réponse des soins de santé |
We report our practice experience in pediatric neurosurgery in a tertiary hospital during pandemic, and the effects
of pandemic on educational issues. COVID-19 pandemic changed all scopes of medical practice and training. Considering the limitation in the available resources, the number of educational cases may decrease in subspecialized disciplines like pediatric neurosurgery.
If pandemic continues, alternative measures should be taken to compensate for the shortcoming in technical and practical training. |
|
|
Mi, T, Yang, et al |
AIDS Behav |
Mental Health |
|
HIV healthcare providers might be vulnerable to mental health problems during the COVID-19 pandemic. Guided by the
stress and coping paradigm, the current study aimed at examining the interactive effects of COVID-19-related stressors and coping on mental health problems. A cross-sectional online survey was conducted among 1029 HIV healthcare providers in Guangxi, China.
The prevalence of depression and anxiety in the current study was 13.31% and 6.61%, respectively. Results from path analyses revealed that the main effects of COVID-19-related stressors and coping were significant on both depression and anxiety. The interaction
of coping and COVID-19-related stressors had significant effects on depression and anxiety. Simple slope tests revealed that more coping behaviors buffered against the negative effect of COVID-19-related stressors on mental health problems. Coping acted as
a protective factor that alleviated the harm of COVID-19-related stressors on mental health. Intervention targeting coping management might benefit the mental health of HIV healthcare providers. |
|
|
Micarelli, A, Granito, et al |
Journal of International Medical Research |
Clinical data| Données cliniques Mental Health |
|
This study aims to survey perceived general and ear-nose-throat (ENT) symptoms of COVID-19 in relation to psychological
impact, mental health, perception of information and demographic characteristics in quarantined subjects during a lockdown period in Italy. Participants reported different prevalences of perceived ENT and general symptoms. Coryza, cough, sore throat and tinnitus
were the most common symptoms, and there was a low prevalence of anxiety, depression and stress compared with the psychological impact of the symptom. Comparison of the two symptom groups demonstrated a common need for updates, their relationship with the
media and correct information about the route of transmission. |
|
|
Miersch, Shane, Li, et al |
bioRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique Immunology | Immunologie |
This study describes the use of advanced protein engineering and modular design principles to develop tetravalent synthetic
nAbs that mimic the multi-valency exhibited by IgA molecules, which are especially effective natural inhibitors of viral disease. And show that highly specific tetravalent nAbs can be produced at large scale and possess stability and specificity comparable
to approved antibody drugs. Moreover, structural studies reveal that the best nAb targets the host receptor binding site of the virus spike protein, and thus, its tetravalent version can block virus infection with a potency that exceeds that of the bivalent
IgG by an order of magnitude. |
|
|
COVID-19 and Indigenous peoples in Chile: vulnerability to contagion and mortality |
Millalen, P, Nahuelpan, et al |
AlterNative |
Epidemiology| Épidémiologie |
This research investigates whether Indigenous Populations are disproportionately vulnerable to COVID-19 infection and
deaths in Chile. To answer this question, we use a regression model to analyze data from the Chilean government. Our analysis indicates that municipalities with a higher proportion of Indigenous people evinced higher rates of infection and deaths to COVID-19.
Indigenous groups were not only highly affected at the beginning of the coronavirus outbreak; their rate of infection and mortality has increased as the virus has spread to the general population. We argue that the COVID-19 pandemic can have devastating effects
on Indigenous communities, mainly because it increases the historically accumulated inequalities and structural racism linked to colonization, neoliberalism, and neo-extractivism in Chile. |
|
Miscio, Leonardo, Olivieri, et al |
Research Square prepub |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The diagnostic accuracy of the point-of-care rapid test "bKIT Virus Finder COVID-19" (Hyris Ltd) is evaluated by a
retrospective and a prospective analysis on SARS CoV-2 samples previously assessed with an FDA “authorized for the emergency use - EUA” reference method. The analysis conclude, the Hyris kit represents a promising tool to improve the health surveillance and
to increase the capacity of SARS-CoV-2 testing. |
|
|
Mishra, S |
Royal Society Open Science |
Coronavirology| Coronavirologie Immunology | Immunologie |
In this study, attempts have been made to find globally conserved epitopes from the entire set of SARS-CoV-2 proteins.
Using diverse computational tools, a ranked list of probable immunogenic, promiscuous epitopes generated through all the three main stages of antigen processing and presentation pathways has been prioritized. One of the most important insights is that all
of the proteins in this pathogen present unique epitopes, so that the targeting of a few specific viral proteins is not likely to result in an effective immune response in humans. Due to the presence of these unique epitopes in all of the SARS-CoV-2 proteins,
stronger immune responses generated by T cell hyperactivation may lead to cytokine storm and immunopathology and consequently, remote chances of human survival. |
|
|
Mistry, J, Chuguransky, et al |
Nucleic Acids Res |
Coronavirology| Coronavirologie |
The Pfam database is a widely used resource for classifying protein sequences into families and domains. To facilitate
research on COVID-19, we have revised the Pfam entries that cover the SARS-CoV-2 proteome, and built new entries for regions that were not covered by Pfam. |
|
|
Moiseev, S, Avdeev, et al |
Ann Rheum Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The objective of our retrospective study was to assess the efficacy of earlier and late intravenous tocilizumab (TCZ),
prior to and after initiation of mechanical ventilation, respectively, in reducing mortality in a cohort of patients with severe COVID-19 pneumonia who required support in ICU. Between 16 March and 5 May 2020, we received medical records of 2066 patients with
a diagnosis of COVID-19 who were admitted to the ICUs for worsening oxygenation. In this sample, 328 patients (57.0% males, median age of 59 years) were considered eligible for TCZ administration. One hundred and fifty-nine of 328 patients received at least
one 400 mg flat dosing of TCZ (21 patients received two infusions with an interval of around 24 hours), whereas the remaining 169 patients were not treated with IL-6 inhibitor usually due to the shortage of medication. TCZ was administered to 83 (60.1%) of
137 patients who needed oxygen therapy or non-invasive ventilation at the point of infusion or submission of medical record by the local hospital (earlier TCZ cohort) and to 76 (39.8%) of 191 intubated patients (late TCZ cohort). In the total population, the
mortality rates did not differ between patients who received TCZ infusion and those who were not treated with IL-6 inhibitor (46.5% and 50.3%, respectively, p=0.509). In both groups, the most common causes of death were acute respiratory distress syndrome
(91.9% and 77.6%, respectively), cardiovascular complications (5.4% and 12.9%) and pulmonary embolism (1.4% and 2.4%). In the earlier TCZ cohort, the mortality rate was twofold lower than in the late TCZ cohort (32.5% and 61.8%, p<0.001). However, neither
earlier nor late TCZ administration resulted in a lower risk of death compared with patients who did not receive TCZ infusion. Age and gender adjusted ORs of death in patients treated with earlier and late TCZ were 2.370 (95% CI 0.969 to 5798; р=0.059) and
0.996 (95% CI 0.539 to 1.839; р=0.989), respectively, compared with untreated patients. Moreover, the earlier TCZ infusion was associated with a higher requirement for mechanical ventilation that retained statistical significance after adjustment for age and
gender (OR 2.507; 95% CI 1.184 to 5.310; р=0.016). This finding could be partly explained by a higher prevalence, although insignificant, of several comorbidities impairing prognosis, that is, coronary artery disease, stroke and type 2 diabetes, in the TCZ
group |
|
|
Moore, TR, Cannaday, et al |
Journal of the Acoustical Society of America |
Transmission |
Brass wind instruments with long sections of cylindrical pipe, such as trumpets and trombones, sound "brassy"when played
at a fortissimo level due to the generation of a shock front in the instrument. It has been suggested that these shock fronts may increase the spread of COVID-19 by propelling respiratory particles containing the SARS-CoV-2 virus several meters due to particle
entrainment in the low pressure area behind the shocks. To determine the likelihood of this occurring, fluorescent particles, ranging in size from 10-50 μm, were dropped into the shock regions produced by a trombone, a trumpet, and a shock tube. Preliminary
results indicate that propagation of small airborne particles by the shock fronts radiating from brass wind instruments is unlikely. © 2020 Acoustical Society of America. |
|
|
Demographic predictors of hospitalization and mortality in U.S. children
with COVID-19 |
Moreira, Alvaro, Chorath, et al |
Research Square prepub |
Epidemiology| Épidémiologie |
Link pediatric population-based data from the United States’ Center for Disease Control and Prevention to COVID-19
hospitalization and in-hospital death. demonstrate that African American [OR 2.28 (95% CI: 1.93, 2.70)] or mixed race [OR 2.95 (95% CI: 2.28, 3.82)] and an underlying medical condition [OR 3.55 (95% CI: 3.14, 4.01)] are strong predictors for hospitalization.
Death occurred in 39 (0.19%) of 20,096 hospitalized children; children with a prior medical condition had an increased odd for death [OR 8.8 (95% CI: 3.7, 21.1)]. |
|
Prediction of lethal outcomes in COVID-19 cases based on the results chest
computed tomography |
Morozov, SP, Gombolevskiy, et al |
Tuberculosis and Lung Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Assessed lethal outcomes in patients with COVID-19 based on the result of chest computed tomography (chest CT) using
a semi-quantitative visual scale of the pulmonary parenchyma lesion. Data of 13,003 patients from the Unified Radiological Information Service were retrospectively included in the study according to inclusion and exclusion criteria. The test aimed to detect
a trend of directional changes in the proportion of deceased patients among various categories using CT 0-4 score demonstrated a statistically significant result. The chance of a lethal outcome increases directionally from CT-0 to CT-4. Analysis of overall
survival using the Cox regression model showed that the assessed factors (age and CT 0-4 score) were statistically significantly associated with the time to death from COVID-19. The risk of death increased with age, on average, 8.6% for every 5 years. When
transferring from one category of CT to the next one, the risk increased by 38% on the average. There was no statistically significant association of gender factor with overall survival. |
|
Parkinson's Disease Remote Patient Monitoring During the COVID-19 Lockdown |
Motolese, F, Magliozzi, et al |
Frontiers in Neurology |
Healthcare Response | Réponse des soins de santé |
Objective: To evaluate the feasibility of a smartphone remote patient monitoring approach in a real-life Parkinson's
disease (PD) cohort during the Italian COVID-19 lockdown. Methods: Fifty-four non-demented PD patients who were supposed to attend the outpatient March clinic were recruited for a prospective study. Results: Forty-five patients (83.3%) ran the app at least
once; Twenty-nine (53.7%) subjects were half-compliant, while 16 (29.6%) were fully compliant. Adherence was hindered by technical issues or digital illiteracy (38.7%), demotivation (24%) and health-related issues (7.4%). Ten patients (18.5%) underwent PD
therapy changes. |
|
Hematologic predictors of mortality in hospitalized patients with COVID-19:
a comparative study |
Mousavi, SA, Rad, et al |
Hematology |
Clinical data| Données cliniques |
Authors aimed to clarify the clinical significance of hematologic parameters alteration in COVID-19. Hematologic laboratory
parameters have always been a crucial component of diagnostic and therapeutic strategies in infectious disease. |
|
Exploring a rural Latino community's perception of the COVID-19 pandemic |
Moyce, S, Velazquez, et al |
Ethn Health |
Public Health response| Interventions de santé publique |
The purpose of our study was to understand the perception of the Latino community in a rural state regarding COVID-19.
DESIGN: Respondents were recruited using snowball sampling as part of a previous effort to establish an academic-community partnership with Latinos in the area. In April 2020, we conducted 14 semi-structured interviews in Spanish with participants over the
phone. RESULTS: Common themes were a wariness of news appearing on social media, generalized worry, and the use of natural medicines to maintain health. Respondents followed recommended guidelines to protect their own health, though expressed concern that
members of their community were not. |
|
Naeem, KB, Hachim, et al |
Saudi Med J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to evaluate acute cardiac injury in COVID-19 patients and its association with adverse
outcomes including mortality in the United Arab Emirates (UAE) population. During the study period, 203 patients were included, of which, 44 (21.7%) had evidence of acute cardiac injury. These patients present with higher comorbidities, have high inflammatory
markers and have greater risk for in-hospital multi-organ damage, need for mechanical ventilation, and death. |
|
|
Nalumansi, A, Lutalo, et al |
Int J Infect Dis |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The aim of this study was to evaluate a low cost, easy-to-use rapid antigen test for diagnosing COVID-19 at the point-of-care.
Sensitivity and specificity of the antigen test were 70.0% (95% CI: 60 - 79) and 92% (95% CI: 87 - 96) respectively; diagnostic accuracy was 84% (95% CI: 79 - 88). The antigen test was more likely to be positive in samples with qRT-PCR Ct values ≤29 reaching
a sensitivity of 92%. |
|
|
Transfusion Reactions Associated with COVID-19 Convalescent Plasma Therapy for SARS-CoV-2 |
Nguyen, FT, van den Akker, et al |
Transfusion |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Retrospectively examined 427 adult inpatient CP transfusions to determine incidence and types of reactions, as well
as clinical parameters and risk factors associated with transfusion reactions. Fifty-five reactions from 427 transfusions were identified (12.9%), and thirteen were attributed to transfusion (3.1%). Reactions were classified as underlying COVID-19 (76%), febrile
non-hemolytic (10.9%), transfusion-associated circulatory overload (9.1%), allergic (1.8%), and hypotensive (1.8%) reactions. Statistical analysis identified increased transfusion reaction risk for ABO blood group B or Sequential Organ Failure Assessment scores
of 12-13, and decreased risk within the age group of 80-89 years. |
|
Communications in the Coronavirus Crisis: Lessons for the Second
Wave |
Nielsen, Rasmus Kleis, Fletcher, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
The coronavirus pandemic is a communications crisis in addition to being a public health emergency. In this report,
based on the results of ten online panel surveys of UK respondents fielded from mid-April to mid-August 2020, we find that: (i) most people are relatively informed but large minority do not feel news media or the government have explained what they can do
in response to the pandemic (ii) information inequality is growing as the crisis continues, and (iii) the ‘infodemically vulnerable’ are a small but significant and growing part of the UK public. |
|
Nikolovska, M, Johnson, et al |
Crime Science |
Public Health response| Interventions de santé publique |
In this paper, we study the use of Twitter for crime mitigation and reduction by UK police (and associated) agencies
in the early stages of the Covid-19 pandemic. Our findings suggest that whilst most of the tweets from our sample concerned issues that were not specifically about crime, especially during the first stages of the pandemic, there was a significant increase
in tweets about fraud, cybercrime and domestic abuse. |
|
|
Niu, B, Liang, et al |
Transbound Emerg Dis |
Epidemiology| Épidémiologie Transmission |
The distribution characteristics and spreading of COVID-19 in various regions of Italy were analyzed by heat maps.
The results showed that the Italian epidemic has a temporal trend and spatial aggregation. The epidemic was concentrated in northern Italy and gradually spread to other regions. Finally, the Google trends index of the COVID-19 epidemic was further employed
to build a prediction model combined with machine learning algorithms. Using the Adaboost algorithm for single-factor modeling. It shows that these six features (Mask, Pneumonia, Thermometer, ISS, Disinfection, Disposable gloves) of the AUC values are all
greater than 0.9, indicating that these features have a large contribution to the prediction model. It's also implied that the public's attention to the epidemic is increasing as well as the awareness of the need for protective measures. |
|
|
Corpus driven analysis of news reports about covid-19 in a malaysian online newspaper |
Nor, NFM, Zulcafli, et al |
GEMA Online Journal of Language Studies |
Mental Health |
|
The present study aims to contribute to research in linguistics about Covid-19, by employing corpus-driven approach
for data analysis. Online newspaper reports about Covid-19 were downloaded from the Star online from March 1st to March 31st, 2020. A total of 1018 news reports were processed and analysed, with 140 themes being identified. The collocates reflect fear, anxiety
and uncertainty that majority of Malaysians feel. It also shows how the virus is taking a toll on Malaysia and Malaysians with regards to economy and social life. On the other hand, some of the collocates portrayed the government to be in total control of
the situation, despite the threat to health and economic situations in the country. Suggestions for future research about Covid-19 include comparison of several newspaper reports from English newspapers in Malaysia, analysis of news report during extended
movement control order (ECMO) in Malaysia or discourse analysis of crisis communication by political leaders in ASEAN. |
|
Provoking tweets by indonesia media twitter in the initial month of coronavirus
disease hit |
Nurlaila, I, Rahutomo, et al |
|
Public Health response| Interventions de santé publique |
In order to assess how likely the COVID-19-containing news being forwarded to reach more readers we crawled data from
Twitter. provoking headline add likelihood for the tweets to be moving forward. |
|
Psychological symptoms of the outbreak of the COVID-19 confinement in Spain |
Odriozola-González, P, Planchuelo-Gómez, et al |
J Health Psychol |
Mental Health |
|
We studied the short-term psychological effects of the COVID-19 crisis and the quarantine on 3550 adults from the Spanish
population in a cross-sectional survey. Symptoms of anxiety, depression, and stress were analyzed using the 21-item version of the Depression Anxiety Stress Scale. Symptoms of posttraumatic stress disorder were analyzed using the Impact of Event Scale. Symptomatic
scores of anxiety, depression, and stress were observed in 20% to 30% of respondents. Symptomatic scores indicating psychological stress were found in 47.5% of respondents. Similar to the findings of other multiple studies, confinement has been found to have
significant emotional impact in the Spanish population. |
|
Olagoke, AA, Olagoke, et al |
J Relig Health |
Public Health response| Interventions de santé publique |
The objective of this study was to examine the role of health locus of control (HLOC) in the relationship between religiosity
and COVID-19 vaccination intention. In a cross-sectional survey (N = 501), we found a significantly negative association between religiosity and COVID-19 vaccination intention. This relationship was partially mediated by external HLOC. Collaborative efforts
with religious institutions may influence COVID-19 vaccine uptake. |
|
|
Olivieri, A, Palù, et al |
Int J Infect Dis |
Epidemiology| Épidémiologie |
The present work aims to reveal correlation between parameters such as COVID-19 incidence, ICU bed occupancy, ICU excess
area and mortality in Italian regions. The analysis could define two separate groups of Italian regions. The examined variables considered within these groups were interlinked and dependent one on each other. The regions of the two groups shared the same kind
of model (linear) explaining mortality as a function of cumulative incidence, but with higher value of the constant in one group, so characterized by a high intrinsic “strength” of the pandemic, certainly playing a major role in the generation of a large number
of severe and life-threatening cases. Other factors can be conditioning mortality and be linked to incidence, such as ICU saturation and excess. |
|
|
Orsucci, G, Rocchi, et al |
Recenti progressi in medicina |
Epidemiology| Épidémiologie Transmission |
Retrospective study of a COVID-19 outbreak that developed in February during a dinner in the municipality of Capannori,
Italy. Of the 47 dinner guests included in the study. 26 people (55.3%) were diagnosed to be infected after the dinner, and developed one or more symptoms, the most frequently encountered symptom was fever. 24 people (76.9% ) with a positive diagnosis were
symptomatic. Attack rate and reproduction number are higher than others in the literature, this is probably due to the conditions in which the dinner took place (i.e. not ventilated environment, absence of safety distances, absence of personal protective equipment). |
|
|
Ortiz-Gomez, Elias |
Research Square prepub |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Chest CT scans are useful for detecting SARS-CoV-2 in patients undergoing bariatric and metabolic surgery (BMS), and
enable healthcare and surgical teams to perform surgeries safely during this COVID-19 pandemic |
|
|
Pala, L, Conforti, et al |
Cancer Invest |
Clinical data| Données cliniques |
We report the case of a patient with metastatic melanoma, long responder to anti PD-1 blockade who got infected with
Sars CoV-2, recovering without sequelae. A critical review of literature was performed. Limited data available in literature support the possibility to continue the immunotherapy in patients with cancer under control. |
|
|
Pan, Y, Li, et al |
Clinical Microbiology and Infection |
Epidemiology| Épidémiologie Immunology | Immunologie |
This study aimed to describe the screening results of 61,437 community members in Wuchang District, Wuhan. A total
of 1470 (2.39%, 95% CI 2.27–2.52) individuals were detected positive for at least one antiviral antibody. Among the positive individuals, 324 (0.53%, 95% CI 0.47–0.59) and 1200 (1.95%, 95% CI 1.85–2.07) were positive for immunoglobulin IgM and IgG, respectively,
and 54 (0.08%, 95% CI 0.07–0.12) were positive for both antibodies. The positive rate of female carriers of antibodies was higher than those of male counterparts (male-to-female ratio of 0.75), especially in elderly citizens (ratio of 0.18 in 90+ age subgroup),
indicating a sexual discrepancy in seroprevalence. In addition, viral nucleic acid detection using real-time PCR had showed 8 (0.013%, 95% CI 0.006–0.026) asymptomatic virus carriers. |
|
|
Pan, Y, Li, et al |
Biomedical Reports |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study identified the risk factors associated with prolonged shedding in patients with coronavirus disease 2019
(COVID-19), and evaluated the effects of current clinical and clinicopathological factors on viral shedding in patients. The median duration of viral shedding in the 186 COVID-19 patients was 13 days. The median duration of viral shedding was 12 days in non-severe
patients, and 17 days in severe patients, and there was a significant difference between the two groups (P<0.001). Multi-factor regression analysis suggested that the onset-hospitalization interval odds ratio (OR), 1.27; 95% confidence interval (CI), 1.15-1.41;
P<0.001] and comorbidity with a chronic disease (OR, 2.43; 95% CI, 1.14-5.17; P=0.021) were independent risk factors for prolonged viral shedding, whereas lopinavir/ritonavir (LPV/r) was an independent protective factor (OR, 0.28; 95% CI, 0.11-0.75; P=0.011).
Umifenovir, and low and short courses of glucocorticoids were not associated with prolonged viral shedding. The prolonged viral shedding was the initial causative factor of persistent aggravation of the patient's conditions. |
|
|
Pang, J, Gao, et al |
Structural Chemistry |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
COVID-19 is spreading in a global pandemic that is endangering human life and health. Therefore, there is an urgent
need to target COVID-19 to find effective treatments for this emerging acute respiratory infection. Viral Papain-Like cysteine protease (PLpro), similar to papain and the cysteine deubiquitinase enzyme, has been a popular target for coronavirus inhibitors,
as an indispensable enzyme in the process of coronavirus replication and infection of the host. Combined structure-based virtual screening, molecular dynamics (MD) simulation, and molecular mechanics/Generalized Born surface area (MM/GBSA) free energy calculation
approaches were utilized for identification of PLpro inhibitors. Four compounds (F403_0159, F112_0109, G805_0497, D754_0006) with diverse chemical scaffolds were retrieved as hits based on docking score and clustering analysis. Molecular dynamics simulations
indicated that the contribution of van der Waals interaction dominated the binding free energies of these compounds, which may be attributed to the hydrophobicity of active site of PLpro from COVID-19. Moreover, all four compounds formed conservative hydrogen
bonds with the residues Asp164, Gln269, and Tyr273. We hoped that these four compounds might represent the promising chemical scaffolds for further development of novel PLpro inhibitors against COVID-19. © 2020, Springer Science+Business Media, LLC, part of
Springer Nature. |
|
|
Paolini, D, Maricchiolo, et al |
Current Psychology |
Mental Health |
|
The lockdown impact on the economy as well as on social and psychological processes is relevant, we conducted an exploratory
study to examine which social factors are associated with the psychological reactions of Italians during the COVID-19 lockdown. Participants (n = 690) self-reported their social identification on three levels (i.e., Italians, Europeans and humankind), their
trust toward social and political actors, and their level of welbeing, interdependent-happiness, and distress. Results showed that the relation between trust and the level of wellbeing and distress was mediated by identification with Italians and humankind,
only the identification with humankind mediated the relationship between trust and the level of interdependent-happiness. |
|
|
Paradiso, AV, De Summa, et al |
J Med Internet Res |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The objective of our study was to compare the results of the rapid serological VivaDiag test for SARS-CoV-2–related
IgM/IgG detection with those of the standard RT-PCR laboratory test for identifying SARS-CoV-2 nucleic acid. The rapid serological test analyzed in this study seems limited in terms of usefulness when diagnosing SARS-CoV-2 infection. However, it may be useful
for providing relevant information on people’s immunoreaction to COVID-19 exposure. |
|
|
Partha’s COVID 19 protocol – a preliminary pilot study in Indian patients |
Parthasarathy, S, Chandramohan, et al |
International Journal of Research in Pharmaceutical Sciences |
Healthcare Response | Réponse des soins de santé |
This study proposes a guideline or a protocol (Partha’s protocol) to categorize and recommend treatments for four categories
of patients and contacts. Results find that there was minimal need for supplemented oxygen and no mortality among the 19 positive cases and their contacts. |
|
From 5Vs to 6Cs: Operationalizing Epidemic Data Management
with COVID-19 Surveillance |
Peddireddy, Akhil Sai, Xie, et al |
medRxiv |
Epidemiology| Épidémiologie Surveillance |
In this paper, we describe our work developing our own COVID-19 Surveillance Dashboard, available at https://nssac.bii.virginia.edu/covid-19/dashboard/,
which offers a universal view of the pandemic while also allowing users to focus on the details that interest them. |
|
Penrod, Y, Garcia, et al |
J Med Virol |
Healthcare Response | Réponse des soins de santé |
Five common transport media (four commercial and one in‐house) were evaluated for their suitability in the collection
of nasopharyngeal swab specimens for subsequent molecular detection of severe acute respiratory syndrome‐associated coronavirus 2 (SARS‐CoV‐2). Results suggest that these transport media provide dependable temporal stability of the SARS‐CoV‐2 virus without
significant analytical interference of molecular assays. These findings are important for addressing critical laboratory supply chain shortages of transport media in the current COVID‐19 health crisis but also for future pandemic planning, when again supplies
of choice commercially‐available transport media likely will be depleted. |
|
|
Petrescu, NB, Aghiorghiesei, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
This study aimed to assess dental care needs in Cluj region (Romania) during the State of Emergency, declared due to
the COVID-19 pandemic, compared to the same period of the year 2019. A descriptive retrospective analysis was conducted, which retrieved patients seeking emergency dental services at the Emergency Department of County General Hospital and “Iuliu Hațieganu”
University of Medicine and Pharmacy. Compared to 2019 (724 patients) in 2020 there were only 160 patients were treated in the same facility. The number of patients with acute apical periodontitis, abscess, and acute pulpitis was significantly higher in 2020.
The percentage of patients receiving sedative filling for the treatment of acute pulpitis in 2020 was significantly higher than in 2019, while the proportion of patients receiving pulpectomy was higher in 2019. |
|
|
Piralla, A, Ricchi, et al |
Int J Infect Dis |
Clinical data| Données cliniques |
In this prospective multicenter study, virus isolation was prospectively attempted in 387 nasal swabs from clinically
recovered patients yet showing low viral load (>30 quantification cycle). The median Cq value was 37.0 (range 30.0 to 39.4). Overall, cytopathic effect was detected in 9 samples corresponding to 2.3% (9/387) of culture positivity rate. |
|
|
FLANNEL: Focal Loss Based Neural Network Ensemble for COVID-19 Detection |
Qiao, Z, Bae, et al |
J Am Med Inform Assoc |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The aim of this study was to test the possibility of differentiating chest x-ray images of COVID-19 against other pneumonia
and healthy patients using deep neural networks. Focal Loss Based Neural Ensemble Network (FLANNEL) consistently outperforms baseline models on COVID-19 identification task in all metrics. Compared with the best baseline, FLANNEL shows a higher macro-F1 score
with 6% relative increase on Covid-19 identification task where it achieves 0.7833± 0.07 in Precision, 0.8609± 0.03 in Recall, and 0.8168± 0.03 F1 score. |
|
Qin, C, Minghan, et al |
Food Science and Nutrition |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To observe lipid profiles and their alterations in hospitalized patients with COVID-19 pneumonia (NCP) and evaluate
the value of lipids for the prediction of the length of hospital stay (LOS), a total of 248 patients aged 18 years or older were enrolled in this retrospective study. Compared with common cases (n = 174), severe cases (n = 74) exhibited higher TG and HDL-C,
and lower LDL-C. Levels of TC and LDL-C were negatively correlated with LOS. In 68 severe cases, serum lipids were followed up during hospitalization, and the median LOS was 29 days. The average levels of serum lipids were lowest at admission and gradually
increased during hospitalization. |
|
|
Qjidaa, M, Ben-Fares, et al |
2020 International Conference on Intelligent Systems and Computer Vision, ISCV 2020 |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this article, we propose a clinical decision support system for the early detection of COVID 19 using deep learning
based on chest radiographic images. For this we will develop an in-depth learning method which could extract the graphical characteristics of COVID-19 in order to provide a clinical diagnosis before the test of the pathogen. For this, we collected 100 images
of cases of COVID-19 confirmed by pathogens, 100 images diagnosed with typical viral pneumonia and 100 images of normal cases. The proposed model achieved an accuracy of 92.5% in internal validation and 87.5% in external validation. For the AUC criterion
we obtained a value of 97% in internal validation and 95% in external validation. Regarding the sensitivity criterion, we obtained a value of 92% in internal validation and 87% in external validation. The results obtained by our model in the test phase show
that our model is very effective in detecting COVID-19 and can be offered to health communities as a precise, rapid and effective clinical decision support system in COVID-19 detection. |
|
|
Early detection of COVID19 by deep learning transfer Model for populations
in isolated rural areas |
Qjidaa, M, Mechbal, et al |
2020 International Conference on Intelligent Systems and Computer Vision, ISCV 2020 |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
To combat the spread of COVID 19, the World Health Organization suggests a large-scale implementation of COVID 19 tests.
Unfortunately, these tests are expensive and cannot be provided and available for people in rural and remote areas. To remedy this problem, we will develop an intelligent clinical decision support system (SADC) for the early diagnosis of COVID 19 from chest
X-rays which are more accessible for people in rural areas. Thus, we collected a total of 566 radiological images classified into 3 classes: a class of COVID19 type, a Class of Pneumonia type and a class of Normal type. In the experimental analysis, 70% of
the data set was used as training set and 30% was used as the test set. After preprocessing process, we use some augmentation using a rotation, a horizontal flip, a channel shift and rescale. Our finale classifier achieved the best performance with test accuracy
of 99%, f1score 98%, precision of 98.60% and sensitivity 98.30%. |
|
Qu, Gaojing, Huang, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective: To characterize C-reactive protein (CRP) changes features from patients with coronavirus disease 2019 (COVID-19)
and to quantify the correlation between CRP value and clinical classification. CRP showed different distribution feature and existed differences in various ages, clinical types and outcomes of COVID-19 patients. The features corresponded with disease progression. |
|
|
Psychological and social impact of COVID-19 in Pakistan:
Need for Gender Responsive Policies |
Rabbani, Dr Fauziah, Khan, et al |
medRxiv |
Mental Health |
|
This study attempted to assess how gender impacts risk perceptions, anxiety levels behavioral responses to the COVID
19 pandemic in Pakistan in order to recommend gender responsive health policies. Of the 1390 respondents, 478 were women, and 913 were men. Women considered their chances of survival to be relatively lower than men (59 % women vs 73% men). They were also more
anxious (62% women vs 50% men), and more likely to adopt precautionary behavior, such as avoiding going to the hospital (78% women vs. 71% men), not going to work (72% women and 57% men), and using disinfectants (93% women and 86% men). Men were more likely
to trust friends, family and social media as reliable sources of COVID-19 information, while women were more likely to trust doctors. |
|
Radnitz, Scott, Hsiao, et al |
SSRN- Lancet prepublication |
Mental Health |
|
Our study addresses support for conspiratorial candidates by highlighting the role of anxiety. In particular, we draw
attention to the distinction between general anxiety, which results from individual disposition and long-term structural forces; and situational anxiety, which arises from unexpected events that produce sudden shocks. We test the effects of general versus
situational anxiety by leveraging the occurrence of the COVID-19 pandemic. Using two survey experiments, one pre-COVIDand the other during the pandemic, we show that situational anxiety but not general anxiety is related to support for conspiratorial candidates.
We also find that the effect of situational anxiety is not limited to conspiracy theories related to COVID-19, but generalizes to other types of conspiracy theory as well. We further find that people who support conspiratorial candidates do not view them as
better equipped to solve the problem than non-conspiratorial ones. |
|
|
Ramalho, Sofia, Trovisqueira, et al |
Research Square prepub |
Mental Health |
|
This study aims to explore associations between disordered eating behaviors in adults during the COVID-19 lockdown
period, and the experienced psychosocial impact of the COVID-19 pandemic, depressive symptomatology, anxiety/stress levels. Participants reported the presence of meal skipping (52.8%), grazing eating behavior (80.9%), overeating (81.0%), loss of control over
eating (47.2%), and binge eating episodes (39.2%) during lockdown. Uncontrolled and emotional eating were significantly correlated with the psychosocial impact of COVID-19 pandemic, depression, anxiety, and stress levels. |
|
|
Ramaswamy, A, Nayak, et al |
Cancer Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This was an observational study, conducted between 12 April and 10 June 2020 at Tata Memorial centre, Mumbai, in cancer
patients undergoing systemic therapy with laboratory confirmed COVID-19. The objectives were to evaluate cumulative 30-day all-cause mortality, COVID-19 attributable mortality, factors predicting mortality, and time to viral negativity after initial diagnosis.
The mortality rates in cancer patients with COVID-19 who are receiving systemic anti-cancer therapy in LMICSs are marginally higher than that reported in unselected COVID-19 cohorts with prolonged time to viral negativity in a substantial number of patients.
The pediatric cancer patients tended to have favorable outcomes. |
|
|
Ramos, G, Vieites, et al |
Revista de Administracao Publica |
Public Health response| Interventions de santé publique |
Despite the medical consensus, many citizens have resisted adhering to and/or supporting social distancing practices.
In a study conducted in Brazil, we examine whether and how support for social distancing varies according to self-identified political orientation and personal economic vulnerability. Results show that while economic vulnerability does not influence support
for social distancing, conservatives are systematically less supportive of these practices than liberals. |
|
|
Rantanen, T, Eronen, et al |
J Gerontol A Biol Sci Med Sci |
Public Health response| Interventions de santé publique |
Potentially, reduced out-of-home mobility and lower activity levels among older people may lower their quality of life
(QOL). We studied cross-sectional and longitudinal associations of and changes in life-space mobility, active ageing and QOL during COVID-19 social distancing compared to two years before. The observed declines indicate compliance with social distancing recommendation,
but underline the importance of participation in meaningful life situations as a factor underlying good QOL also during COVID-19 pandemic. |
|
|
Rav-Acha, M, Orlev, et al |
Int J Clin Pract |
Clinical data| Données cliniques |
Authors describe a single center cohort of hospitalized patients with a positive nasopharyngeal swab for COVID-19 during
the initial Israeli outbreak. Arrhythmia prevalence is associated with age, disease severity, heart failure (CHF), and troponin levels. |
|
|
Reiner, RC, J, et al |
Nature medicine |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
Using our SEIR model, and projections of critical driving covariates (pneumonia seasonality, mobility, testing rates
and mask use per capita), we assessed scenarios of social distancing mandates and levels of mask use. We find that achieving universal mask use (95% mask use in public) could be sufficient to ameliorate the worst effects of epidemic resurgences in many states.
Universal mask use could save an additional 129,574 (85,284–170,867) lives from September 22, 2020 through the end of February 2021. |
|
|
The Manifestation of Oral Mucositis in COVID-19 Patients: A case-series |
Riad, A, Kassem, et al |
Dermatol Ther |
Clinical data| Données cliniques |
Hereby we demonstrate the characteristics of thirteen laboratory-confirmed coronavirus disease (COVID-19) patients
with oral mucositis according to the CARE guidelines. The mean onset of mucositis emergence was 0.85 ± 0.8 (0-2) days calculated since the day of PCR testing, while its mean duration was 8.62 ± 3.07 (7-14) days. |
|
Riello, M, Purgato, et al |
Royal Society Open Science |
Mental Health |
|
In this survey-based epidemiological study, we test the prevalence of anxiety and post-traumatic symptomatology in
residential nursing and care home workers during the COVID-19 pandemic. We do this by focusing on the North of Italy, the most affected region during the first COVID-19 outbreak in Italy. Using a single-stage cluster design, our study returns an estimate
for the prevalence of moderate-to-severe anxiety and/or post-traumatic symptomatology of 43%, with an 18% prevalence of comorbidity among workers. Women and workers who had recently been in contact with COVID-19-positive patients/colleagues are more likely
to report moderate-to-severe symptoms. |
|
|
Riley, H, Stabile, et al |
R I Med J (2013) |
Healthcare Response | Réponse des soins de santé |
This study sought to implement a transitional home-based treatment plan (HBTP) to patients. Of the 129 patients that
received a HBTP, 115 (89%) participated in follow-up correspondence (63±12 years, 83% white, 66% male, 81% enrolled in cardiac rehab). Nearly 70% of patients continued to participate in regular exercise and upon re-opening, 69 (60%) of patients returned to
center-based care. Psychosocial factors appeared to inhibit treatment adherence. |
|
|
Rinzivillo, Calogero, Conte, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Study a new fractal model for prediction of contagions of CoViD-19 (Sarbeco Betavirus SARS-CoV-2) from August 24, 2020
to July 31, 20201 in Apulia, Italy. The model analysis suggests the time of the peak is estimated to be at December 7, 2020 and the number of contagions to be about 575 cases. |
|
|
Variables protecting mental health in the Spanish population affected by the COVID-19
pandemic |
Robles-Bello, M, Sánchez-Teruel, et al |
Current Psychology |
Public Health response| Interventions de santé publique |
The aim of this study is to identify whether psychosocial and socio-demographic variables that act as protective factors
in adverse situations play a role in the level of resilience achieved by individuals in a sample affected by the COVID-19 pandemic. 1227 homebound people (863–70.3% women), aged 18–73 years (M = 28.10; SD = 12.88) reported on sociodemographic and psychological
variables such as optimism, hope, self-efficacy and post-traumatic growth. Having a higher academic level (β =.47; CI (95%) =.11–.34; p <.01), being autonomous (β =.29; CI (95%) = 0.1–.09; p <.01), along with self-efficacy (β =.42; CI (95%) =.71–92; p <.01)
and to a lesser extent optimism (β =.31; CI (95%) =.63–.84; p <.01) would be the predictive variables of a resilient outcome. A high level of statistical power (1-β = 1) and effect size (f2 = 19.2) is observed. The Spanish population exposed to confinement
presents high levels of resilience, but no relevant post-traumatic growth has taken place. |
|
Are there pulmonary sequelae in patients recovering from COVID-19? |
Rogliani, P, Calzetta, et al |
Respir Res |
Long-Term Sequelae |
|
It has been recently hypothesized that infection by SARS-CoV-2 may lead to fibrotic sequelae in patients recovering
from COVID-19. In this observational study, hospitalized patients with COVID-19 had a high-resolution computed tomography of the chest performed to detect the extension of fibrotic abnormalities. At follow-up, the lung density significantly improved in both
lungs and in each lobe of all patients, being in the normal range. This study provides preliminary evidence that hospitalized patients with mild-to-moderate forms of COVID-19 are not at risk of developing pulmonary fibrosis. |
|
T-wave inversion as a manifestation of COVID-19 infection: a case series |
Romero, J, Alviz, et al |
J Interv Card Electrophysiol |
Clinical data| Données cliniques |
We conducted an observational, retrospective study of confirmed COVID-19 cases with at least one electrocardiogram
(ECG) in a large hospital in New York City (March 23, 2020–April 23, 2020). Patients with new T-wave inversion (TWI) or pseudonormalization were further analyzed. Our study demonstrates that new TWI is a relatively common finding in COVID-19 patients. Importantly,
our findings suggest that new TWI or T-wave pseudonormalization, particularly with elevated troponin, was associated with higher rates of mechanical ventilation and in-hospital mortality. |
|
Rosenberg, AR, Weaver, et al |
Journal of pain and symptom management |
Mental Health |
|
We aimed to describe the pandemic's impact on pediatric palliative care clinicians' personal and professional well-being.
Respondents described burdens more commonly than they did benefits (67% vs. 33% of comments, respectively). Personal burdens related to increased fear and uncertainty, fear of bringing the virus home, and a sense of collective grief. Professional burdens included
a sense of exhaustion, a challenge with work-life balance, personal experiences with colleagues infected with the virus, and considerations of leaving health care altogether. Personal benefits included lessons learned, an evolving sense of what matters, and
improved work-life balance. Professional benefits included opportunities for professional development and a sense of professional purpose. |
|
|
Roth, Catharina, Breckner, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
The present study aimed to assess the beliefs and practices of primary care physicians who either led a SARS-CoV-2
contact point or a primary care practice in Baden-Wuerttemberg during the first wave of the COVID-19 pandemic. About half participants of both groups did not fear an own infection with the novel virus (between 50.8% and 65.2%), however about 75 % feared financial
loss. SARS-CoV-2 contact points treated on average more patients with (suspected) COVID-19 than primary care practices. |
|
|
Runkel, S, Kowalzik, et al |
Clinical laboratory |
Epidemiology| Épidémiologie Immunology | Immunologie |
The presence of SARS-CoV-2 IgG-positive antibodies in the sera of 673 blood donors residing in south-western Germany
before and 3,880 donors after the advent of the COVID-19 pandemic was determined and confirmed using two highly sensitive serological tests. Approximately 0.40% of the donors assessed during the COVID-19 pandemic possessed SARS-CoV-2 IgG-positive antibodies,
decidedly fewer than the percentage of SARS-CoV-2-infected individuals determined by real-time RT-PCR nationwide. |
|
|
Rut, W, Lv, et al |
Science Advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Viral papain-like cysteine protease (PLpro, NSP3) is essential for SARS-CoV-2 replication and represents a promising
target for the development of antiviral drugs. Here, we used a combinatorial substrate library and performed comprehensive activity profiling of SARS-CoV-2 PLpro. On the scaffold of the best hits from positional scanning, we designed optimal fluorogenic substrates
and irreversible inhibitors with a high degree of selectivity for SARS PLpro. |
|
|
Use of remdesivir in the presence of elevated LFTs for the treatment of severe COVID-19
infection |
Sabers, AJ, Williams, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
An 82-year-old man with an extensive medical history presented to the emergency room with complaints of generalised
weakness and cough. He tested positive for COVID-19 10 days prior to presenting to the emergency room. Although his symptoms started a week prior to diagnosis, his weakness increased, warranting emergency response. A comprehensive metabolic panel was drawn
from the patient on admission, indicating markedly high liver function tests (LFTs) ≥20 times above the upper limit of normal. On day 1 of admission, the decision was still made to start remdesivir (5-day course) due to decompensated acute respiratory failure
as well as dexamethasone. The patient's LFTs significantly improved throughout his hospital stay. The patient made a full recovery and was discharged on day 10 of hospitalisation. |
|
A mathematical analysis of ongoing outbreak COVID-19 in India through nonsingular derivative |
Safare, KM, Betageri, et al |
Numerical Methods for Partial Differential Equations |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The pivotal aim of the present investigation is to analyze and examine the evolution of COVID‐19 in India with the
available data in two cases first from the beginning to 31st March and beginning to 23rd April in order to show its exponential growth in the crucial period. |
|
Sahin, D, Tanacan, et al |
Int J Gynaecol Obstet |
Clinical data| Données cliniques |
The objective of this study was to investigate the clinical course and impact of coronavirus disease 2019 (COVID-19)
infection on pregnant women. The course of COVID-19 was mild in the majority of cases. However, increased rates of pregnancy complications and cesarean delivery were observed. |
|
|
Saracoglu, KT, Simsek, et al |
Clin Psychopharmacol Neurosci |
Mental Health |
|
We aimed to analyse the risk for healthcare providers during COVID-19 pandemic in a university hospital. The data of
208 participants were analyzed. Mean age was 29 ± 7.748 years, 72.1% were male, 67.3% were nurses, 62% were working in intensive care units, 38% were in hospital wards, 62% of all participants were living alone. Moderate depression was the most frequently
detected outcome (n = 90, 43.3%). Mean The Fear of COVID-19 Scale for all participants was 18.56 ± 7.731. The mean PSQI of patients was 6.18 ± 4.356 with a 45.7% rate of poor sleep quality. PSQI was found significantly higher in nurses (7.1 ± 4.7, p = 0.000).
Nurses were the group with the highest deterioration in sleep quality (53.6%, p = 0.003). The rate of moderate-to-severe depressive symptoms was significantly higher in intensive care unit nurses and physicians (p = 0.018). PSQI score was found significantly
higher in intensive care unit nurses and physicians than hospital ward co-workers (7.02 ± 4.59 vs. 4.81 ± 3.57 respectively, p = 0.001). A significant positive correlation was observed between PSQI and The Fear of COVID-19 Scale total score in all patients
(p < 0.005). |
|
|
Seetulsingh, P, Kannangara, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
This report presents a case of a man in his late 50s, brought to the hospital following a cardiac arrest and prolonged
unsuccessful resuscitation. The history was typical for COVID-19 with fever for 10 days and worsening shortness of breath. His throat and nasal swabs (after death) were negative for SARS-CoV-2. A limited diagnostic autopsy was performed after 27 days, and
lung swabs confirmed presence of SARS-CoV-2. This case highlights the importance of lung swabs when initial upper respiratory tract swabs are negative and proves that the virus can be detected from dead human tissue almost a month later. |
|
|
Evaluation of Olfactory Acuity in Patients with Coronavirus Disease 2019 (COVID-19) |
Shah, NN, Hussain, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Clinical data| Données cliniques |
The objective of this study was to describe the prevalence and characteristics of olfactory dysfunction (OD) in patients
with laboratory-confirmed COVID-19 infection. The early recognition of olfactory dysfunction should help to screen, identify and thereby quickly isolate mildly symptomatic COVID-19 patients from the general population and the existence of these dysfunctions
may well be a prognostic factor in the course of the disease. |
|
Compositional diversity and evolutionary pattern of coronavirus accessory proteins |
Shang, J, Han, et al |
Brief Bioinform |
Coronavirology| Coronavirologie |
Here, we developed a standardized genome annotation tool for coronavirus (CoroAnnoter) by combining open reading frame
prediction, transcription regulatory sequence recognition and homologous alignment. Using CoroAnnoter, we annotated 39 representative coronavirus strains to form a compositional profile for all of the accessary proteins. Large variations were observed in the
number of accessory proteins of 1-10 for different coronaviruses, with SARS-CoV-2 and SARS-CoV having the most (9 and 10, respectively). The variation between SARS-CoV and SARS-CoV-2 accessory proteins could be traced back to related coronaviruses in other
hosts. The genomic distribution of accessory proteins had significant intra-genus conservation and inter-genus diversity and could be grouped into 1, 4, 2 and 1 types for alpha-, beta-, gamma-, and delta-coronaviruses, respectively. Evolutionary analysis suggested
that accessory proteins are more conservative locating before the N-terminal of proteins E and M (E-M), while they are more diverse after these proteins. Furthermore, comparison of virus-host interaction networks of SARS-CoV-2 and SARS-CoV accessory proteins
showed that they share multiple antiviral signaling pathways, those involved in the apoptotic process, viral life cycle and response to oxidative stress. |
|
Shatla, MM, Khafagy, et al |
Clinical laboratory |
Mental Health |
|
This study aimed to address public concerns, and assess mental health changes, and the factors associated with mental
health burden in response to the COVID-19 outbreak in Saudi Arabia after the full lockdown is widely employed. A total of 1,921 responded to the questionnaire. Of them, 1,429 (74.5%) were ≤ 45 years old, and 967 (50.3%) were males. Reported public concerns
included disturbed lifestyle, getting self or family member infected, loss job or part of income, difficult access to routine health care, and 55.8% reported negative impact on their mental health. Hospital anxiety and depression scale revealed high rates
of depression 717 (37.3%)], and anxiety 508 (26.4%)]. Binary logistic regression revealed that female gender, working for the private sector, smokers, and people with chronic diseases were at increased risk of mental illnesses (p < 0.05). |
|
|
The effect of eviction moratoriums on the transmission
of SARS-CoV-2 |
Sheen, Justin, Nande, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de sant&eacute; publique |
Here we model the effect of evictions on SARS-CoV-2 epidemics, simulating viral transmission within and among households
in a theoretical metropolitan area. We find, across scenarios, that evictions lead to significant increase in infections. Applying our model to Philadelphia using locally-specific parameters shows that the increase is especially profound in models that consider
realistically heterogenous cities in which both evictions and contacts occur more frequently in poorer neighborhoods. |
|
The usual suspects: do risk tolerance, altruism, and health predict the response
to COVID-19? |
Sheth, K, Wright, et al |
Review of Economics of the Household |
Public Health response| Interventions de santé publique |
We survey college students during California’s stay-at-home order to test whether compliance with social distancing
requirements depends on primary preferences and characteristics that affect their marginal benefit from doing so. We find a quarter of students violated the order. Yet, neither risk preference, altruism, nor preexisting health conditions were predictive of
compliance. Our findings raise doubt about the efficiency of minimally enforced social distancing policies, as well as commonly assumed motivations for compliance. |
|
End-point RT-PCR: a potential alternative for diagnosing coronavirus disease
2019 (COVID-19) |
Silva Júnior, JVJ, Merchioratto, et al |
J Virol Methods |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We described a one-step end-point RT-PCR for molecular detection of the SARS-CoV-2 E gene. The analytical sensitivity
of the RT-PCR was about 7.15-9 copies of vRNA/μL. The RT-PCR was able to detect SARS-CoV-2 infection in asymptomatic individuals. Nonspecific amplifications were not observed in SARS-CoV-2 negative samples. |
|
Silva, GABE, Saraiva, et al |
Revista de Administracao Publica |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We calculated the Structure Efficiency Index (IEE) of the states’ 92 municipalities and positioned them on the pandemic
curve. It was possible to verify that the government of the State of Rio de Janeiro needs to start acting to suppress COVID-19, maintaining the policy of providing more hospital beds, and purchasing equipment. |
|
|
Expanding Access to COVID-19 Tests through US Postal Service Facilities |
Singh, B, Risanger, et al |
Med Decis Making |
Public health interventions*| Interventions de sant&eacute; publique |
We make a case for provisioning COVID-19 tests through the United States Postal Service (USPS) facilities and demonstrate
a simple method for selecting locations to improve access. We provide quantitative evidence that even a subset of USPS facilities could provide broad access, particularly in remote and at-risk communities with limited access to health care. we estimate that
more than 94% of the US population would be willing to travel to an existing USPS facility if warranted. For half of the US population, this would require traveling less than 2.5 miles from home; for 90%, the distance would be less than 7 miles. We also discuss
the option of distributing test-at-home kits via USPS instead of private carriers. |
|
Skaarup, KG, Lassen, et al |
JACC: Cardiovascular Imaging |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to assess the prevalence and value of assessing myocardial impairment using echocardiography and cardiac biomarkers
in hospitalized patients with COVID-19. In this multi-center study, we found that myocardial impairment is a common finding in hospitalized patients with COVID-19 and that it is associated with a higher risk of developing ARDS. We do not propose that impaired
systolic function due to COVID-19 infection is a causal agent of ARDS development. Although we found that a combination of cardiac biomarkers and echocardiographic measures could rule out patients at high risk of developing ARDS, the results were based on
a low number of events, which are reflected in the low specificity and positive predictive value. |
|
|
Sofian, FA |
|
Public Health response| Interventions de santé publique |
This study analyzes YouTube video content created by five individual Indonesian YouTubers who have the most subscribers.
The study results show that YouTubers use credible speakers on the ethos aspect to convey information to their audience. The pathos aspect appears in serious nonverbal messages to influence the emotions of the audience. The logos aspect is verbal messages
(arguments and pieces of evidence) that contains information about the characteristics of COVID-19, health protocols during a pandemic, critics to government decision making, and socio-economic impacts of coronavirus pandemic. |
|
|
Søvik, S, Bådstøløkken, et al |
Acta Anaesthesiol Scand |
Clinical data| Données cliniques |
This prospective study from a tertiary hospital evaluated the mortality rates in COVID-19 patients with mechanical
ventilation. Consecutive SARS-CoV-2 positive adult patients admitted to the ICU for mechanical ventilation 10.03.20-04.05.20 were included. Of the 1484 persons in the hospital catchment area testing positive for SARS-CoV-2, 201 (13.5%) were hospitalized. Thirty-eight
(19%) patients were mechanically ventilated, of whom five (13%) died. Of 163 patients treated with supplemental oxygen, eight (5%) died. In ventilated patients (75% males, age 61 (53-70) years), severe, moderate, and mild ARDS was present in 25%, 70%, and
5%. Tidal volume ≤8 mL/kg ideal bodyweight was achieved in 34 (94%) of patients. Proning and neuromuscular blockers were used in 19 (54%) and 20 (61%). Duration of ventilation was 12 days (8-23). D-dimer peaked 3.8 mg/L (2.1-5.3), maximum dalteparin dose was
15,000 IU/24h (10,000-15,000). Despite organizational changes a high degree of adherence to treatment protocols was achieved. |
|
|
Sriram, K, Insel, et al |
Physiol Rev |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We present a framework for mechanisms of thrombosis in COVID-19 that initially derive from interaction of SARS-CoV-2
with ACE2, resulting in dysregulation of angiotensin signaling and subsequent inflammation and tissue injury. Inhibitors of thrombin and purinergic receptors may thus have therapeutic effects by blunting platelet-mediated thromboinflammation and dysfunction
in other cell types. Such inhibitors include agents (e.g., anti-platelet drugs) approved for other indications and that could be repurposed to treat, and potentially improve the outcome of, COVID-19 patients. |
|
|
Stevens, BruceR |
bioRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
This study explored the the roles of B0AT1 relating to COVID-19 manifestations assigned to intestinal and renal epithelial
cells and cardiomyocytes and hypothesized that B0AT1 steers the organ-related interplay amongst ACE2, TMPRSS2, ADAM17, and SARS-CoV-2 RBD. The study employed molecular docking modeling that indicated active site catalytic pocket residues of TMPRSS2 and ADAM17
each formed bonds ≤ 2 Å with monomer ACE2 specific residues within a span R652-D713 involved in cleaving sACE2 soluble ectodomain release. These bonds are consistent with competitive binding interactions of experimental anti-SARS-CoV-2 drug small molecules
including Camostat and Nafamostat. Without B0AT1, ACE2 residues K657 and N699 dominated docking bonding with TMPRSS2 or ADAM17 active sites, with ACE2 R710 and R709 contributing electrostatic attractions, but notably ACE2 S708 never closer than 16-44 Å. The
results implicate B0AT1−and in particular the 2ACE2:2B0AT1 complex−as a major player in the landscape of COVID-19 pathophysiology engaging TMPRSS2 and ADAM17, consistent with experimental evidence in the literature and in clinical reports. |
|
|
Clinical Practice During the COVID-19 Pandemic: A Cross-Sectional Survey of Attending Dermatologists |
Stewart, CR, Lipner, et al |
Dermatol Ther |
Healthcare Response | Réponse des soins de santé |
An anonymous 31-question survey was emailed to attending dermatologists at our institution who were encouraged to distribute
the survey to dermatology colleagues. Surveys were collected from 5/26/20 to 6/25/20 and there were 113 respondents. There was a significant increase in telemedicine utilization across the country during the study period. Only 25.0% of dermatologists reported
utilizing telemedicine prior to the COVID-19 pandemic, and 93.2% reported use during the study period, a 272.7% increase. |
|
Strasburg, VJ, Hammes, et al |
Scientia Medica |
Healthcare Response | Réponse des soins de santé |
Publicize the actions related to the development of a contingency plan and the provision of meals to workers at a public
university hospital in southern Brazil during the coronavirus pandemic. The hospital cafeteria served, on average, more than 2,500 lunches before the COVID-19 pandemic began in Brazil. Actions developed by the hospital administration allowed remote work by
workers. However, an average of 1,500 lunches is still served daily. In this study, the actions are presented in order to guarantee an adequate environment that does not transmit outbreaks to workers in the hospital environment. Among some actions are issues
of menu pattern, guidance, and mandatory handwashing by all users, visual signage on-site, and the internal website, among others. The actions have been effective since there are no records of a COVID-19 outbreak among hospital workers. |
|
|
Strasser, EF, Steininger, et al |
Transfusion |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Validated commercially available PCR systems for the frequency of SARS-CoV-2 RNAemia in blood donors .The validation
of the SARS-CoV-2 RT-PCR assay for blood demonstrated high sensitivity, specificity, intra- and inter-assay precision and efficiency. The LOD95 for SARS-CoV-2 RNA was 5.0 genome copies/mL (95% CI, 3.3-12 copies/ml) for target 1 and 4.3 genome copies/mL (95%
CI, 2.9-10 copies/ml) for target 2. In a cohort of 39 CCP donors with 66 CCP donations no SARS-CoV-2 RNA in plasma was detected. Screening of 25 blood samples of 19 ICU COVID-19 patients showed six positive results for SARS-CoV-2 RNA in at least one target
of the assay. |
|
|
Sumida, TomokazuS, Dulberg, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study shows that IFN-I regulates co-inhibitory receptors expression on human T cells, inducing PD-1/TIM-3/LAG-3
while surprisingly inhibiting TIGIT expression. High-temporal-resolution mRNA profiling of IFN-I responses enabled the construction of dynamic transcriptional regulatory networks uncovering three temporal transcriptional waves. The study found that the dynamic
IFN-I response in vitro closely mirrored T cell features with acute IFN-I linked viral infection, with high LAG3 and decreased TIGIT expression. The gene regulatory network identified SP140 as a key regulator for differential LAG3 and TIGIT expression. The
construction of co-inhibitory regulatory networks induced by IFN-I with identification of unique transcription factors controlling their expression may provide targets for enhancement of immunotherapy in cancer, infectious diseases, and autoimmunity. |
|
|
Blood Test Results of Pregnant COVID-19 Patients: An Updated Case-Control Study |
Sun, G, Zhang, et al |
Frontiers in Cellular and Infection Microbiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Methods: A case-control study was carried out based on clinical blood test results. Pregnant COVID-19 patients, pregnant
COVID-19 patients with diabetes, and pregnant COVID-19 patients with hypertension, were assessed in this study. Also, 120 controls were matched. . Results: Between January 24 and March 14, 2020, 60 pregnant COVID-19 patients delivered at the Maternal and Child
Health Hospital of Hubei Province. In total, 21.67% (13/60) were diagnosed with diabetes and 18.33% (11/60) were diagnosed with hypertension during pregnancy. Compared to controls, pregnant COVID-19 patients showed significantly lower numbers of blood lymphocytes
and higher numbers of neutrophils, as well as higher levels of C-reactive protein and total bilirubin. Among the three groups, pregnant COVID-19 patients with diabetes had significantly higher levels of neutrophils and lower levels of total protein. |
|
Sun, Jialei |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study expressed and purified the RNA-dependent RNA polymerase (RdRp) nsp12 of SARS-CoV and developed a primer
extension assay for the evaluation of nsp12 activity. Found that nsp12 could efficiently extend single-stranded RNA, while having low activity towards double-stranded RNA. Nsp12 required a catalytic metal (Mg2+ or Mn2+) for polymerase activity and the activity
was also K+-dependent, while Na+ promoted pyrophosphorylation, the reverse process of polymerization. To identify antivirals against nsp12, a competitive assay was developed containing 4 natural rNTPs and a nucleotide analog, and the inhibitory effects of
24 FDA-approved nucleotide analogs were evaluated in their corresponding active triphosphate forms. Ten of the analogs, including 2 HIV NRTIs, could inhibit the RNA extension of nsp12 by more than 40% and showed dose-dependent inhibition. In addition, the
24 nucleotide analogs were screened on SARS-CoV primase nsp8 which revealed stavudine and remdesivir were specific inhibitors to nsp12. Furthermore, the 2 HIV NRTIs were evaluated on 2019-nCoV nsp12 which showed inhibition as well. Then expanded the evaluation
to all 8 FDA-approved HIV NRTIs and discovered 5 of them, tenofovir, stavudine, abacavir, zidovudine and zalcitabine, could inhibit the RNA extension by nsp12 of SARS-CoV and 2019-nCoV. |
|
|
Sun, Qing, Li, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The studies demonstrated that the QuantiVirus™ SARS-CoV-2 multiplex test has a limit of detection (LOD) of 200 copies/mL
in contrived saliva samples. The clinical performance of saliva-based testing is comparable to that of NPS-based testing. Pooling of saliva specimens for SARS-CoV-2 detection is feasible. |
|
|
Tabery, P, Pilnacek, et al |
European Societies |
Public Health response| Interventions de santé publique |
The aim of our study is to examine the relationship between different types of trust during the coronavirus crisis.
Using a sample representative of the adult population of the Czech Republic, our text discusses what the network structure of trust is like during the current pandemic. We find that the institutions or actors that are directly involved in resolving the crisis,
such as security institutions and medical professionals, are located at the centre of the network of trust. |
|
|
Myeloid cell dynamics correlate with clinical outcomes of severe coronavirus
disease 2019 |
Takano, Tomohiro, Matsumura, et al |
Research Square prepub |
Clinical data| Données cliniques Immunology | Immunologie |
We tracked cellular dynamics of myeloid-derived suppressor cell (MDSC) subsets and examined whether any of them correlate
with disease severity and prognosis by flow cytometric analysis of blood samples from COVID-19 patients. We observed that polymorphonuclear (PMN)-MDSCs, rather than other MDSC subsets, transiently expanded in severe cases but not in mild or moderate cases. |
|
Blood ozonization in patients with mild to moderate COVID-19 pneumonia: a single
centre experience |
Tascini, C, Sermann, et al |
Intern Emerg Med |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We performed a case–control study involving hospitalized adult patients with confirmed COVID-19 with mild to moderate
pneumonia to ascertain to effectiveness of auto-hemotherapy treated with an oxygen/ozone (O2/O3) gaseous mixture as adjuvant therapy. A decrease of SIMEU (Società Italiana di Medicina di Emergenza-Urgenza) clinical phenotypes was observed (2.70 ± 0.67 vs.
2.35 ± 0.88, p = 0.002) in all patients during hospitalization but this clinical improvement was statistically significant only in O3-treated patients (2.87 ± 0.78 vs. 2.27 ± 0.83, p < 0.001), differently to the control group (2.53 ± 0.51 vs. 2.43 ± 0.93,
p = 0.522). No adverse events were observed associated with the application of O2/O3 gaseous mixture. O2/O3 therapy as adjuvant therapy could be useful in mild to moderate pneumonia due to SARS-CoV-2. |
|
Temkin, E, Schwaber, et al |
Clinical Microbiology and Infection |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
We aimed to compare the prevalence of asymptomatic COVID-19 among clinical staff in designated COVID-19 units versus
that among staff in similar units with no known or suspected COVID-19 patients. We conducted a cross-sectional survey of healthcare workers (HCWs) in eight Israeli general hospitals. There were 522 participants: 291 from COVID-19 units and 231 from comparison
units. Only one participant (0.2%, 95% CI: 0.005–1.1%)—an asymptomatic nurse on a COVID-19 unit—tested positive for SARS-CoV-2. In participating COVID-19 units there were two symptomatic HCWs with confirmed COVID-19 in the 2 weeks before the survey; both were
infected by contact with a co-worker outside of the COVID-19 unit. |
|
|
Sensitivity and specificity of SARS-CoV-2 S1 subunit in COVID-19 serology assays |
Tian, Y, Lian, et al |
Cell Discovery |
Coronavirology| Coronavirologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Our aim is to determine which components or forms of the S protein is more sensitive and specific in ELISA assays to
detect and differentiate anti-SARS-CoV-2-specific antibodies from antibodies elicited by the widely circulating CoVs. Here, we report that the S1 subunit of the SARS-CoV-2 S protein has superiority over the receptor-binding domain (RBD) and the native state
S trimer in terms of sensitivity and specificity, respectively, in measuring anti-SARS-CoV-2 antibodies from COVID-19 convalescent patients. Our results show that the S1 subunit protein of SARS-CoV-2 is both sensitive and specific in distinguishing COVID-19
antibodies, suggesting its potential implication in large-scale serological testing, especially in determining the efficacy of SARS-CoV-2 vaccine. |
|
An open toolbox for generating map of actively confirmed sars-cov-2 or covid-19 cases
in vietnam |
Tran, DC |
Bulletin of Electrical Engineering and Informatics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This work presents an open toolbox for generating map of actively “Confirmed” cases in a country, i.e., Vietnam, given
a dataset containing their statuses and current locations, detail down to provincial-or state-, city-level. The newly released algorithm reduced approximately 24.41% of processing time of the preceding one. In addition, the algorithm can be easily extended
for supporting other countries given suitable datasets. |
|
Tree, JA, Turnbull, et al |
Br J Pharmacol |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Seven different heparin preparations including unfractionated heparin (UFH) and low molecular weight heparins (LMWH)
of porcine or bovine origin were screened for antiviral activity against live SARS-CoV-2 (Australia/VIC01/2020) using a plaque inhibition assay with Vero E6 cells. Interaction of heparin with spike protein RBD was studied using differential scanning fluorimetry,
and the inhibition of RBD binding to human ACE2 protein using ELISA assays was examined. This comparison of clinically relevant heparins shows UFH has significantly stronger SARS-CoV-2 antiviral activity compared to LMWHs. UFH acts to directly inhibit binding
of spike protein to the human ACE2 protein receptor. Overall the data strongly support further clinical investigation of UFH as a potential treatment for patients with COVID-19. |
|
|
Trudeau, JM, Alicea-Planas, et al |
Economics and Human Biology |
Public Health response| Interventions de santé publique |
We distributed a web-based, contingent valuation survey to social-media users in 16 Latin American countries to evaluate
regional attitudes towards the emerging COVID-19 outbreak and WTP for COVID-19 testing. We observe that the cost of the test and household income are important determinants of testing intentions. We find higher WTP among those reporting greater concern relative
to the average respondent. Accounting for uncertainty, our results indicate a WTP of approximately $45 dollars or 4.2 % of monthly income among respondents. |
|
|
Investigation of the importance of climatic factors in COVID-19 worldwide intensity |
Tzampoglou, P, Loukidis, et al |
International Journal of Environmental Research and Public Health |
Epidemiology| Épidémiologie |
This study aimed to investigate the correlation of COVID-19 case and death rates with possible causal climatological
and sociodemographic factors for the March to May 2020 (first wave) period in a worldwide scale by statistically processing data for over one hundred countries. The weather parameters considered herein were air temperature, relative humidity, cumulative precipitation,
and cloud cover, while sociodemographic factors included population density, median age, and government measures in response to the pandemic. The results of this study indicate that there is a statistically significant correlation between average atmospheric
temperature and the COVID-19 case and death rates, with chi-square test p-values in the 0.001–0.02 range. Regarding sociodemographic factors, there is an even stronger dependence of the case and death rates on the population median age (p = 0.0006–0.0012).
Multivariate linear regression analysis using Lasso and the forward stepwise approach revealed that the median age ranks first in importance among the examined variables, followed by the temperature and the delays in taking first governmental measures or issuing
stay-at-home orders. |
|
Uccelli, M, Cesana, et al |
Obes Surg |
Epidemiology| Épidémiologie |
The purpose of this study was to investigate the incidence of SARS-CoV-2 infection and its severity in patients who
have undergone bariatric surgery. A total of 2145 patients (313 male; 1832 female) replied to the questionnaire. Mean presurgical BMI: 44.5 ± 6.8 kg/m2. Mean age: 44.0 ± 10.0 year. Mean BMI after surgery: 29.3 ± 5.5 kg/m2 (p < 0.05). Although the reported
rates of symptoms and fever were high, only 0.6% of patients tested positive for COVID-19. Among more than 2000 patients who underwent bariatric surgery analyzed in this study, only 0.1% needed ICU admission. |
|
|
Umucu, E, Tansey, et al |
Rehabilitation Counseling Bulletin |
Mental Health |
|
Explored the potential protective role of character strengths and virtues in moderating the negative effects of COVID-19
on stress and well-being. A higher degree of multiple character strengths significantly and independently moderated the relationship between COVID-19-related stress and well-being. Findings suggested the importance of promoting more character strengths overall
in people with chronic conditions and disabilities to help them better manage COVID-19-related stress and enhance well-being. |
|
|
Structural Entropy of Daily Number of COVID-19 Related
Fatalities |
Unlu, Eren |
medRxiv |
Economics | Économie |
A recently proposed temporal correlation-based network framework applied on financial markets called Structural Entropy
has prompted us to utilize it as a means of analysis for COVID-19 fatalities across countries. Our observation on the resemblance of volatility of fluctuations of daily novel coronavirus related number of deaths to the daily stock exchange returns suggests
the applicability of this approach.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo fundingAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee
approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:NaNAll necessary patient/participant consent has been obtained and the appropriate institutional forms have
been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered
and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research
reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData are public coronavirus statistics |
|
van Hensbergen, Mitch, den Heijer, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques Coronavirology| Coronavirologie |
In this report, we describe the first known COVID-19 outbreak in a Dutch long-term care facility (LTCF). Since the
start of the outbreak, nineteen (19%) residents tested positive for COVID-19. Eleven samples were sequenced, along with three random samples from COVID-19 patients hospitalized in the regional hospital at the time of the LTCF outbreak. All samples were linked
to COVID-19 cases from the cross-border region of Heinsberg, Germany. Symptoms were reported only in about two third of the cases, and tended to be generally mild. |
|
|
Varela Barca, L, Torralba Cloquell, et al |
Interact Cardiovasc Thorac Surg |
Clinical data| Données cliniques |
We present a case report of fatal respiratory failure after cardiac surgery in the early stages of the coronavirus
disease 2019 outbreak. Although not supported by epidemiological data nor clinical course, coronavirus disease 2019 infection was revealed post-mortem by immunohistochemical detection of the severe acute respiratory syndrome coronavirus 2 spike protein in
lung tissue. |
|
|
Vogelzang, EH, Loeff, et al |
J Immunol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
We developed a sensitive total Ab bridging assay to detect SARS-CoV-2 Abs. The developed bridging assays reliably
detect SARS-CoV-2 Abs in hospitalized and nonhospitalized patients and are therefore well suited to conduct seroprevalence studies. |
|
|
von der Thüsen, JH, van Bommel, et al |
Journal of Hematopathology |
Clinical data| Données cliniques |
n this paper, we describe the co-occurrence of hemophagocytic lymphohistiocytosis and extensive pulmonary microvascular
damage with thrombosis and its sequelae in a patient with fatal COVID-19. We believe these response patterns may be linked by common mechanisms involving hypercytokinemia and require further investigation as a fatal constellation in COVID-19, to generate appropriate
treatment in patients who display these combined features. |
|
|
Wacharapluesadee, S, Buathong, et al |
Frontiers in Public Health |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study reports the efficacy of family-wide polymerase chain reaction (PCR) in screening, detecting, and identifying
initial cases of the novel SARS-CoV-2 in Thailand. Combining family-wide PCR, as a rapid screening tool, with NGS, for full genome characterization, could facilitate early detection and confirmation of a novel pathogen and enable early containment of a disease
outbreak. |
|
|
Wagner, L, Corona, et al |
J Autism Dev Disord |
Healthcare Response | Réponse des soins de santé |
The present study describes a model of tele-assessment for autism spectrum disorder (ASD) in young children, implemented
in direct response to disruptions in care caused by the COVID-19 pandemic. We present preliminary data on the outcomes and provider perceptions of tele-assessments, together with several lessons learned during the period of initial implementation. Results
indicated that child age and TELE-ASD-PEDS scores linearly related to provider diagnostic certainty and providers reported feeling comfortable completing tele-assessments, making diagnoses of ASD following tele-assessment, and providing feedback and recommendations
to families via telemedicine. |
|
|
Features of creatine-kinase in COVID-19 patients
within various specific periods: A cohort study |
Wan, Shanshan, Qu, et al |
medRxiv |
Clinical data| Données cliniques |
All cases underwent 504 tests of CK since symptom onset and the median value was 51.7 (35.0-91.5) U/L. The first median
value on the day 8 from exposure onset was 78.1 (69.1-85.8) U/L then showed an upward trend from the day 8 to the day 12 (reaching a peak of 279.3 U/L), finally showed a fluctuation decline after the day 12. The CK median value in critical cases reached the
peak (625.5 U/L) on the transforming date, and then decreased rapidly to the normal range. Before death, the CK median value in dead cases firstly increased until the day −14 with a peak as 470.0 U/L, then decreased with fluctuation until day −2, and finally
increased again on the day 0. |
|
Wan, Shanshan, Qu, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objectives To study the features of creatine-kinase (CK) in COVID-19 patients with different ages, clinical types and
outcomes and quantify the relationship between CK value and clinical type. The peak median value of CK in cases aged ≥ 71 years old (appeared at T2) was higher than that in cases aged ≤ 70 years old. There was statistical difference between the two groups
(P=0.001). Similarly, the peak in critical cases (appeared at T2) was higher than moderate and severe types, and significant difference were existed among moderate, severe, and critical types (P=0.000). Moreover, the peak value in death group (appeared at
T2) was higher than those in survival group. Significant difference was also found between them (P=0.000). According to the optimal scale regression model, the CK value (P=0.000) and age (P=0.000) were associated with the clinical type. |
|
|
Wang, L, Lv, et al |
PeerJ |
Epidemiology| Épidémiologie |
The aim of this study was to evaluate the prognositc accuracy of the Modified Early Warning Score (MEWS) for in-hospital
mortality in older adults with COVID-19. Among the 235 patients included in this study, 37 (15.74%) died and 131 (55.74%) were male, with an average age of 70.61 years (SD 8.02). We found MEWS is an efficient tool for rapid assessment of elderly COVID-19 patients.
MEWS has promising performance in predicting in-hospital mortality and identifying the high-risk group in elderly patients with COVID-19. |
|
|
Wang, Qianqian, Li, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We performed a retrospective study of 65 patients with COVID-19 from Wuhan Huoshenshan Hospital, of which 13 patients
were diagnosed with lung cancer. During treatment, lung cancer survivors infected with SARS-CoV-2 had a shorter median time from symptom onset to hospitalization and longer clinical symptom remission time than non-cancer individuals. No differences were observed
among indicators such as time from symptom onset to hospitalization and symptom remission time between long-term and short-term survivors. The expression of ACE2 and TMPRSS2 was elevated in lung cancer survivors as compared with that in non-cancer individuals. |
|
|
Modeling the load of SARS-CoV-2 virus in human expelled particles during coughing
and speaking |
Wang, Y, Xu, et al |
PLoS One |
Transmission Infection Prevention and Control/ Prévention et contrôle des infections
(IPAC/PCI) |
In this study, using a set of differential equations describing the evolution of respiratory droplets and by using
the SARS-CoV-2 virus as an example, the authors investigated the distribution of airborne virus in human expelled particles from coughing and speaking. From a single cough, a person with a high viral load in respiratory fluid (2.35 × 109 copies per ml) may
generate as many as 1.23 × 105 copies of viruses that can remain airborne after 10 seconds, compared to 386 copies of a normal patient (7.00 × 106 copies per ml). Masking, however, can effectively block around 94% of the viruses that may otherwise remain airborne
after 10 seconds. The study also found that no clear size boundary exists between particles that can settle and can remain airborne. |
|
Warren, ReneL, Birol, et al |
medRxiv |
Epidemiology| Épidémiologie |
Here, we report on HLA-I and HLA-II alleles, along with their associated risk significance in one such cohort of 126
patients, including COVID-19 positive (n=100) and negative patients (n=26). While enrichment of these alleles falls below statistical significance after Bonferroni correction, COVID-19 patients with the latter three alleles tend to fare worse overall. |
|
|
A model for pH coupling of the SARS-CoV-2 spike protein
open/closed equilibrium |
Warwicker, Jim |
bioRxiv |
Coronavirology| Coronavirologie |
SARS-CoV-2 is thought to release its RNA genome at either the cell surface or within endosomes, the balance being dependent
on spike protein stability, and the complement of receptors, co-receptors and proteases. This research investigated possible mediators of pH-dependence, pKa calculations were made on a set of structures for spike protein ectodomain and fragments from SARS-CoV-2
and other coronaviruses. Dominating a heat map of the aggregated predictions, 3 histidine residues in S2 are consistently predicted as destabilising in pre-fusion (all 3) and post-fusion (2 of 3) structures. Other predicted features include the more moderate
energetics of surface salt-bridge interactions, and sidechain-mainchain interactions. Two aspartic acid residues in partially buried salt-bridges have pKas that are calculated to be elevated and destabilising. Notably, the degree of destabilisation is predicted
to vary between open and closed receptor binding domain conformations. It is therefore suggested that these groups contribute to a pH-dependence of the open/closed equilibrium. |
|
Wegner, RE, Horne, et al |
Journal of Radiosurgery and SBRT |
Healthcare Response | Réponse des soins de santé |
In early March 2020 we rapidly implemented suggested changes according to ASTRO and other consensus guidelines as they
relate to stereotactic radiosurgery in the COVID-19 era. We reviewed the GK Icon schedule at our institution between January 01 and April 30, 2020. Seventy-seven patients were treated on the GK Icon over that period, for a total of 231 fractions. The number
of unique patients varied from 18 (April) to 22 (January). Of the 77 patients only 5 were treated using a frame. The number of fractions per month decreased significantly over time, from 70 in January to 36 in April. Likewise, the percentage of single fraction
cases increased from 4.5% per month in January to 67% in April. |
|
|
Wehenkel, C |
PeerJ |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
The aim of this study was to analyze the association between COVID-19 related deaths and influenza vaccination rate
(IVR) in elderly people worldwide. To accurately estimate the influence of IVR on COVID-19 deaths and mitigate effects of confounding variables, a sophisticated ranking of the importance of different variables was performed, including as predictor variables
IVR and some potentially important geographical and socioeconomic variables as well as variables related to non-pharmaceutical intervention. The results showed a positive association between COVID-19 deaths and IVR of people ≥65 years-old. |
|
|
Epidemic Guard: A COVID-19 Detection System for Elderly People |
Wei, W, Wang, et al |
|
Healthcare Response | Réponse des soins de santé |
In this paper, we propose a real-time robot-based COVID-19 detection system: Epidemic Guard. It combines speech recognition,
keyword detection, cough classification, and medical services to convert real-time audio into structured data to record the user’s real condition. |
|
Weng, Ying Li, Naik, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Recent scientific evidences have suggested that the main protease (Mpro) enzyme in SARS-CoV-2 can be an ideal drug
target due to its crucial role in the viral replication and transcription processes. Therefore, there are ongoing research efforts to identify drug candidates against SARS-CoV-2 Mpro that resulted in hundreds of X-ray crystal structures of ligand bound Mpro
complexes in the protein data bank (PDB) that describe structural details of different chemotypes of fragments binding within different sites in Mpro. This study performed rigorous molecular dynamics (MD) simulation of 62 reversible ligand-Mpro complexes in
the PDB to gain mechanistic insights about their interactions at atomic level. Using a total of ~2.25 microseconds long MD trajectories, identified and characterized different pockets and their conformational dynamics in the apo Mpro structure. |
|
|
Wong, MCS, Ng, et al |
BMJ Global Health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de sant&eacute;
publique |
This study examined epidemiological features of patients with COVID-19 in the context of containment policies between
the first and second waves in Hong Kong. The incidence and mortality (135.5 and 0.5 per 1 000 000 population) was among the lowest in the world. Aggressive escalation of border control correlated with reductions in R t from 1.35 to 0.57 and 0.92 to 0.18,
and aversions of 450 and 1650 local infections during the first and second waves, respectively. Implementing COVID-19 tests for overseas returners correlated with an upsurge of asymptomatic case detection, and shortened containment delay in the second wave.
Medium-sized cluster events in the first wave were family gatherings, whereas those in the second wave were leisure activities among youngsters. Containment delay was associated with older age (adjusted OR (AOR)=1.01, 95% CI 1.00 to 1.02, p=0.040), male gender
(AOR=1.41, 95% CI 1.02 to 1.96, p=0.039) and local cases (AOR=11.18, 95% CI 7.43 to 16.83, p<0.001), and with significant improvement in the second wave compared with the first wave (average: 6.8 vs 3.7 days). A higher incidence rate was observed for males,
raising possibility of gender predilection in susceptibility of developing symptoms. |
|
|
Xie, SL, Huang, et al |
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Analyzed the epidemiological characteristics of cases of asymptomatic infection of the new coronavirus pneumonia (COVID-19)
reported in Guangdong Province. A total of 325 asymptomatic cases of COVID-19 were reported from January 14 to March 31, 2020. The epidemic curve is similar to that of confirmed cases, and there are two peaks, respectively, from January 27 to February 5 and
March 17-26. Among the 325 cases, 56.6% were subsequently converted to confirmed cases and were asymptomatic infections in the incubation period. Their median age was 40 years old. 93.5% of the asymptomatic infections in the incubation period were tested for
nucleic acid in the first sample. Symptoms appeared within 3 days of positive; 43.4% remained asymptomatic and belonged to recessive infections, accounting for 8.6% of reported new coronavirus infections during the same period. Their median age was 27 years
old. The median time from the first sample test positive to discharge from the hospital was 14 days, and 90.8% of the recessively infected persons were discharged from the hospital within 28 days and transferred to centralized isolation and observation. The
longest time interval from the first sample test positive to the last sample test positive 73 d. The positive rate of close contacts associated with hidden infections was 0.3%, and the positive rate of close contacts associated with asymptomatic infections
during the incubation period was 2.2%. There were statistically significant differences in the age and source of infection between asymptomatic infections and hidden infections during the incubation period. The high-age group is the risk factor for the first
time reported as "asymptomatic infection of COVID-19" to become a confirmed case. Compared with the 0-19-year-old group, 40-59 years old and ≥60 years old are the risk factors of asymptomatic infection being converted Factors, OR values were 2.730 and 5.302,
respectively. Asymptomatic infections in China are more likely to be converted to confirmed cases ( OR = 7.121). |
|
|
Xiong, Lian, Yan, et al |
Research Square prepub |
Mental Health |
|
This study aimed to study the psychological impact of COVID-19 on Chinese residents outside the Hubei province and
the relationship among impact of event, self-regulated fatigue and self-control. We found that the residents suffered a psychological impact during the outbreak of COVID-19 .The more self-controlled they were, the more self-regulated fatigue and psychological
impact they suffered, and self-control could not only had an direct influence on psychological impact but also had affected it indirectly through self-regulated fatigue. |
|
|
Yang, H, Hu, et al |
Journal of Public Health (Germany) |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This study aims to investigate the association between population migration and the number of confirmed COVID-19 cases
in China while investigating its measures for pandemic prevention and control using a SEIRD model. Empirical results revealed that an increase of 1000 persons migrating from Wuhan raised the number of confirmed cases by 4.82 persons. |
|
|
Yang, H, Hu, et al |
Journal of Public Health (Germany) |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de sant&eacute; publique |
This study aims to investigate the association between population migration and the number of confirmed COVID-19 cases
in China. This study confirmed the positive association between population migration and the number of confirmed COVID-19 cases. |
|
|
Yang, J, Liao, et al |
American Journal of Emergency Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to investigate whether the elevated cardiac biomarkers could become effective prognostic predictors
for COVID-19 patients. After 28-day follow-up, overall 357 patients were divided into death group (n = 25) and survival group (n = 332), or non-recovery group (n = 43) and recovery group (n = 314). The LASSO regression analysis showed elevated CK-MB and myoglobin
were independent risk predictors for in-hospital death, and CK-MB and myoglobin were also independent risk predictors for non-recovery. The AUC of CK-MB and myoglobin for in-hospital death were 0.862 (95% CL: 0.804–0.920, p < 0.001) and 0.838 respectively
(95% CL: 0.729–0.947, p < 0.001). The AUC of CK-MB and myoglobin for non-recovery were 0.839 (95% CL: 0.786–0.892, p < 0.001) and 0.841 (95% CL: 0.765–0.918, p < 0.001) respectively. We also found AUC of combined use of CK-MB and myoglobin for in-hospital
death and non-recovery were 0.883 (95 CL: 0.813–0.952, p < 0.001), and 0.873 (95% CL: 0.817–0.930, p < 0.001) respectively. In patients with COVID-19, elevated CK-MB and myoglobin on admission may be effective predictors for adverse outcomes, and combined
use of CK-MB and myoglobin had a better performance for prediction. |
|
|
Yepes-Pérez, AF, Herrera-Calderon, et al |
Evidence-based Complementary and Alternative Medicine |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The druggability of Mpro could be used for discovering drugs to treat COVID-19. A multilevel computational study was
carried out to evaluate the potential antiviral properties of the components of the medicinal herb Uncaria tomentosa (Cat's claw), focusing on the inhibition of Mpro. The in silico approach starts with protein-ligand docking of 26 Cat's claw key components,
followed by ligand pathway calculations, molecular dynamics simulations, and MM-GBSA calculation of the free energy of binding for the best docked candidates. Our findings suggest the potential effectiveness of Cat's claw as complementary and/or alternative
medicine for COVID-19 treatment. |
|
|
Yu, X, Wang, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
To help radiologists interpret images, we developed an automatic CT image-based detection system, which achieved high
accuracy on the detection of COVID-19. |
|
|
Zakout, YM, Khatoon, et al |
Saudi Med J |
Public Health response| Interventions de santé publique |
The objective of this study was to assess the role of the COVID-19 pandemic in improving personal hygiene in Saudi
Arabia. The percentages of respondents who always washed their hands after coming back home, used soap to wash their hands, used a hand sanitizer outside, wore a face masks while outside and washed their hands before preparing and/or eating food increased
during the pandemic. The percentage of respondents who never shake hands with people they know increased from 0% before the pandemic to 62.6% during the pandemic. The mean duration of washing hands with soap significantly increased from 13.31 seconds before
the pandemic to 28.01 seconds during the pandemic |
|
|
Mental Health Outcomes in Perinatal Women During the Remission Phase of COVID-19
in China |
Zeng, X, Li, et al |
Frontiers in Psychiatry |
Mental Health |
|
The aim of this study was to assess the symptoms of anxiety, depression, insomnia and quality of life (QOL) in perinatal
women and to identify potential risk factors associated with these symptoms. Coping strategies that relieve psychological stress during the COVID-19 outbreak should be provided to prevent adverse outcomes for women and their infants. |
|
Comparison of spatiotemporal characteristics of the COVID-19 and SARS outbreaks
in mainland China |
Zhang, X, Rao, et al |
BMC Infect Dis |
Epidemiology| Épidémiologie |
This study investigated whether COVID-19 and SARS exhibited similar spatial and temporal features at provincial level
in mainland China. Compared to SARS, COVID-19 had a higher overall incidence. Identified 3 clusters (predominantly located in south-central China; the highest RR = 135.08, 95% CI: 128.36-142.08) for COVID-19 and 4 clusters (mainly in Northern China; the highest
RR = 423.51, 95%CI: 240.96-722.32) for SARS. Fewer secondary clusters were identified after the "Wuhan lockdown". The LISA cluster map detected a significantly high-low (Hubei) and low-high spatial clustering (Anhui, Hunan, and Jiangxi, in Central China) for
COVID-19. Two significant high-high (Beijing and Tianjin) and low-high (Hebei) clusters were detected for SARS. |
|
Mean platelet volume/platelet count ratio predicts severe pneumonia of COVID-19 |
Zhong, Q, Peng, et al |
J Clin Lab Anal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective study, 85 patients with confirmed COVID‐19 were enrolled and divided into low and high platelet
mean volume/platelet count ratio (MPR) group in order to assess the relationship between MPR and disease severity. Results indicate that high MPR level is an independent risk factor for severe pneumonia in patients with COVID‐19. |
|
Zhu, Haoming, Qu, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We collected all included patients' general information, clinical type, hydroxybutyrate dehydrogenase (α-HBDH) value
and outcome, and analyzed α-HBDH values within different initial time and different periods. α-HBDH value increases in some COVID-19 patients, obviously in severe type, critical type and death patients, and mainly in 18 days after exposure onset and 10 days
after symptom onset. In brief, α-HBDH is an important indicator to judge the severity and prognosis of COVID-19. |
|
|
Using social media data to assess the impact of COVID-19 on mental health
in China |
Zhu, Yongjian, Xie, et al |
Research Square prepub |
Mental Health |
|
To assess the causal impact of COVID-19 on psychological changes in China, we constructed a city-level panel data set
based on the expressed sentiment in the contents of 13 million geotagged tweets on Sina Weibo. We found a significant deterioration in mental health status after the occurrence of COVID-19. We also observed that this psychological effect faded out over time
during our study period and was more pronounced among women, teenagers and older adults. The mental health impact was more likely to be observed in cities with low levels of initial mental health status, economic development, medical resources, and social
security. |
|
A stochastic time-delayed model for the effectiveness of Moroccan COVID-19 deconfinement
strategy |
Zine, Houssine, Boukhouima, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de sant&eacute; publique |
In this paper, we propose a delayed stochastic mathematical model to predict the epidemiological trend of COVID-19
in Morocco after the deconfinement. Numerical simulations are performed in order to test the efficiency of the deconfinement strategies chosen by the Moroccan authorities to help the policy makers and public health administration to make suitable decisions
in the near future. |
|
Zou, R, Wu, et al |
Frontiers in Endocrinology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, the thyroid function of COVID-19 patients was assessed and factors associated with outcomes were analyzed
to determine the potential predictive value of ESS. Methods: Clinical and laboratory data of COVID-19 patients with or without ESS in Changsha, China, were collected and analyzed on admission. Results: Forty-one (27.52%) cases of COVID-19 patients diagnosed
with ESS. ESS patients had higher proportions of fever, shortness of breath, hypertension, diabetes, and severe events than those of non-ESS patients. The regression analysis showed that ESS was significantly associated with the disease severity of COVID-19. |
|
|
Pediatric COVID-19 and the factors that may mitigate its clinical course |
Abdel-Aziz, M, Abdel-Aziz, et al |
Journal of Child Science |
Review Literature| Revue de littérature |
|
|
COVID-19 Genetic and Environmental Risk Factors: A Look at the Evidence |
Abdelzaher, H, Saleh, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
|
|
33073946; Covid-19 Pandemic: Through the Lens of Science, a Painstaking Review |
Alsrhani, A, Junaid, et al |
Clinical laboratory |
Review Literature| Revue de littérature |
|
|
Ashwini, K, Anjali, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
|
|
|
Babayeva, M, Loewy, et al |
Pharmacogenomics and Personalized Medicine |
Review Literature| Revue de littérature |
|
|
|
Barrett, JS |
Br J Clin Pharmacol |
Review Literature| Revue de littérature |
|
|
|
Monocyte HLA-DR measurement by flow cytometry in COVID-19 patients: an interim review |
Benlyamani, I, Venet, et al |
Cytometry A |
Review Literature| Revue de littérature |
|
|
From Influenza Virus to Novel Corona Virus (SARS-CoV-2)–The Contribution of Obesity |
Bhattacharya, I, Ghayor, et al |
Frontiers in Endocrinology |
Review Literature| Revue de littérature |
|
|
Bhattacharyya, A, Kumar, et al |
Indian Journal of Pharmacology |
Review Literature| Revue de littérature |
SR-MA:In our study, no difference was seen between the L/R combination and the SOC arm in terms of “progression to
more severe state,” “mortality,” and virological cure on days 7–10;” however, some benefits in terms of “duration of hospital stay” and “time to virological cure” were seen. No significant difference in efficacy was seen when L/R was compared to arbidol and
HCQ monotherapy. Except for the occurrence of diarrhea, which was higher in the L/R group, safety profile of L/R is comparable to SOC. |
|
|
Boregowda, U, Gandhi, et al |
Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine |
Review Literature| Revue de littérature |
|
|
|
Brandão-de-Resende, C, Diniz-Filho, et al |
Clin Exp Ophthalmol |
Review Literature| Revue de littérature |
|
|
|
Cagnazzo, F, Arquizan, et al |
J Neurol |
Review Literature| Revue de littérature |
SR: review was conducted on PubMed, EMBASE, and SCOPUS. This updated review of literature, shows that headache, skeletal
muscle injury, psychiatric disorders, impaired consciousness, and gustatory/olfactory dysfunction were the most common neurological symptoms of COVID-19 patients. Impaired consciousness and acute cerebrovascular events were significantly higher among patients
with a severe infection. AIS patients required ICU admission in 63% of cases, while intra-hospital mortality rate was close to 23%. |
|
|
Cawood, AL, Walters, et al |
Nutrients |
Review Literature| Revue de littérature |
|
|
|
Cervantes-Pérez, E, Cervantes-Guevara, et al |
Curr Nutr Rep |
Review Literature| Revue de littérature |
|
|
|
Can mesenchymal stem cells be used to treat COVID-19-induced pneumonia? (review) |
Çetin, İ, Topçul, et al |
Biomedical Reports |
Review Literature| Revue de littérature |
|
|
Chakole, S, Jaiswal, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
|
|
|
Clinical linkage of covid-19 with hypertension, diabetes and cardiovascular disease |
Chhajer, B, Singh, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
|
|
Chisale, MasterRO, Ramazanu, et al |
Research Square prepub |
Review Literature| Revue de littérature |
SR: PubMed, EMBASE, PsycINFO, AMED, CINAHL, DOAJ, Medline and Google Scholar for articles published from December 2019
to August 2020. his systematic review has identified the community-based interventions implemented in LMICs to prevent COVID-19 during the pandemic and key factors affecting the level of KAP among the population.
|
|
|
Cioca, G, Skowron, et al |
Systematic Reviews in Pharmacy |
Review Literature| Revue de littérature |
|
|
|
D’Errico, S, Zanon, et al |
Microorganisms |
Review Literature| Revue de littérature |
SR: The post-mortem investigation highlighted that acute respiratory distress syndrome (ARDS) and multiple organ failure
represent the main clinical features of COVID-19 disease, often leading to pulmonary thromboembolism and superimposed bronchopneumonia. The discussed data showed a strict relationship among the inflammatory processes, diffuse alveolar, and endothelial damage. |
|
|
Dagys, J |
Problemos |
Review Literature| Revue de littérature |
|
|
|
De Cieri, H, Lazarova, et al |
Human Resource Management Review |
Review Literature| Revue de littérature |
|
|
|
Lung ultrasound: The future ahead and the lessons learned from COVID-19 |
Demi, L |
Journal of the Acoustical Society of America |
Review Literature| Revue de littérature |
|
|
Lymphopenia as a marker for disease severity in COVID-19 patients: A meta-analysis |
Devanandan, P, Puvvada, et al |
Asian Pacific Journal of Tropical Medicine |
Review Literature| Revue de littérature |
MA: An extensive literature search is carried out in PubMed, Scopus and Google Scholar for articles published between
1st January 2020 and 20th March 2020. In conclusion, there is a 4-fold higher risk of disease severity either ICU care or death in patients who have a low lymphocyte count at the baseline. Low lymphocyte count may affect drug selection.
|
|
Dhamad, AE, Abdal Rhida, et al |
PeerJ |
Review Literature| Revue de littérature |
|
|
|
Di Castelnuovo, A, Costanzo, et al |
Vascular Pharmacology |
Review Literature| Revue de littérature |
MA: analyzed 4069 unselected patients with laboratory-confirmed SARS-CoV-2 infection and hospitalized in 34 clinical
centers in Italy from February 19, 2020 to May 23, 2020. In this observational study and meta-analysis of the literature, ACE-I or ARB use was not associated with severity or in-hospital mortality in COVID−19 patients.
|
|
|
Central Nervous System Manifestations Associated with COVID-19 |
Divani, AA, Andalib, et al |
Curr Neurol Neurosci Rep |
Review Literature| Revue de littérature |
|
|
Duan, L, Zheng, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
|
|
|
Insights into the use of mesenchymal stem cells in COVID-19 mediated acute respiratory
failure |
Durand, N, Mallea, et al |
npj Regenerative Medicine |
Review Literature| Revue de littérature |
|
|
Elsawah, HK, Elsokary, et al |
Rev Med Virol |
Review Literature| Revue de littérature |
SR-MA: Several electronic databases were searched for candidate studies up to 12 October 2020. Remdesivir reduced serious
adverse effects by absolute 6% and no significant Grade 3 or 4 adverse effects were reported. At this early stage of the pandemic, there is evidence that remdesivir can be safely administered for hospitalized Covid-19 patients. It improves the recovery rate
in both moderate and severe patients but, the optimal effect is achieved for those who are severely affected but not mechanically ventilated. |
|
|
Fabre, JB, Grelot, et al |
BMJ Open Sport and Exercise Medicine |
Review Literature| Revue de littérature |
|
|
|
Fatima, S, Haider, et al |
Drug Metab Pers Ther |
Review Literature| Revue de littérature |
|
|
|
Immunomodulatory Therapies for COVID-19 in Solid Organ Transplant Recipients |
Fernández-Ruiz, M, Aguado, et al |
Current Transplantation Reports |
Review Literature| Revue de littérature |
|
|
Rethinking Urban and Food Policies to Improve Citizens Safety After COVID-19 Pandemic |
Galimberti, A, Cena, et al |
Frontiers in Nutrition |
Review Literature| Revue de littérature |
|
|
Role of renin-angiotensin system in acute lung injury caused by viral infection |
Gao, YL, Du, et al |
Infection and Drug Resistance |
Review Literature| Revue de littérature |
|
|
García-Salido, A, Antón, et al |
An Pediatr (Barc) |
Review Literature| Revue de littérature |
|
|
|
Gavriatopoulou, M, Ntanasis-Stathopoulos, et al |
Clin Exp Med |
Review Literature| Revue de littérature |
|
|
|
Gosavi, S, Shrivastav, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
|
|
|
The Impact of COVID-19 Social Restrictions on Trauma Presentations in South Australia |
Harris, D, Ellis, et al |
Emerg Med Australas |
Review Literature| Revue de littérature |
|
|
Roadmap to the Bioanalytical Testing of COVID-19: From Sample Collection to Disease
Surveillance |
Hosseini, A, Pandey, et al |
ACS Sens |
Review Literature| Revue de littérature |
|
|
Ingole, SS, Bhutada, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
|
|
|
Joshi, S, Parkar, et al |
Int J Infect Dis |
Review Literature| Revue de littérature |
|
|
|
Kamboj, S, Kamboj, et al |
Letters in Drug Design and Discovery |
Review Literature| Revue de littérature |
|
|
|
mRNA technology for the development of vaccines against infectious diseases |
Ke, Z, Wang, et al |
Chinese Journal of Microbiology and Immunology (China) |
Review Literature| Revue de littérature |
|
|
Kolcun, JPG, Ryu, et al |
J Neurosurg Spine |
Review Literature| Revue de littérature |
SR: Using PubMed, Scopus, and the Cochrane Library, the authors performed a systematic review. The current increase
in TM adoption due to the COVID-19 crisis presents an opportunity to further develop and validate this technology. Early evidence in the literature supports the use of TM as an adjunct to traditional in-person clinical encounters for certain perioperative
tasks such as supplemental patient education and postoperative surveys. |
|
|
Lazarus, Gilbert, Budiman, et al |
Research Square prepub |
Review Literature| Revue de littérature |
SR-MA: Eligible studies published up to 14 September 2020 were included. Our findings indicated that ICI treatment
should not be adjourned nor terminated during the current pandemic. |
|
|
Stroke and Novel Coronavirus Infection in Humans: A Systematic Review and Meta-Analysis |
Lee, KW, Yusof Khan, et al |
Frontiers in Neurology |
Review Literature| Revue de littérature |
SR-MA: searched Medline, Cinahl, and PubMed for studies related to stroke and COVID-19 from inception up to June 4,
2020. The occurrence of stroke in patients with COVID-19 infection is uncommon, but it may pose as an important prognostic marker and indicator of severity of infection, by causing large vessels occlusion and exhibiting a thrombo-inflammatory vascular picture. |
|
Lengen, JC, Kordsmeyer, et al |
Zentralblatt fur Arbeitsmedizin, Arbeitsschutz und Ergonomie |
Review Literature| Revue de littérature |
|
|
|
Medicinal chemistry strategies in seeking coronavirus inhibitors |
Li, J, Jiang, et al |
Yaoxue Xuebao |
Review Literature| Revue de littérature |
|
|
Lim, L, Matalanis, et al |
J Card Surg |
Review Literature| Revue de littérature |
|
|
|
Loades, ME, Chatburn, et al |
J Am Acad Child Adolesc Psychiatry |
Review Literature| Revue de littérature |
SR: searched MEDLINE, PsycInfo, and Web of Science for articles published between January 1, 1946, and March 29, 2020.
Children and adolescents are probably more likely to experience high rates of depression and most likely anxiety during and after enforced isolation ends. This may increase as enforced isolation continues. |
|
|
Lu, Y, Xiang, et al |
Chinese Journal of Microbiology and Immunology (China) |
Review Literature| Revue de littérature |
|
|
|
Ma, NL, Peng, et al |
Environ Res |
Review Literature| Revue de littérature |
|
|
|
Role of Information Technology for Successful Responses to Covid-19 Pandemic |
Manalu, EPS, Muditomo, et al |
|
Review Literature| Revue de littérature |
|
|
How Useful is COVID-19 Antibody Testing – A Current Assessment for Oncologists |
Maple, PAC, Sikora, et al |
Clinical oncology |
Review Literature| Revue de littérature |
|
|
Police institutions in the face of the pandemic: Sensemaking, leadership, and discretion |
Matarazzo, G, Fernandes, et al |
Revista de Administracao Publica |
Review Literature| Revue de littérature |
|
|
Computerized monitoring of COVID-19 trials, studies and registries in ClinicalTrials.gov
registry |
Mayer, CS, Huser, et al |
PeerJ |
Review Literature| Revue de littérature |
|
|
McStay, R, Johnstone, et al |
Clinical radiology |
Review Literature| Revue de littérature |
|
|
|
Progress of artificial intelligence diagnosis and prognosis technology for COVID-19 medical
imaging |
Meng, L, Li, et al |
Journal of Image and Graphics |
Review Literature| Revue de littérature |
|
|
Meng, X, Lou, et al |
European journal of pharmacology |
Review Literature| Revue de littérature |
|
|
|
Mohammed, AH, Blebil, et al |
AIDS Reviews |
Review Literature| Revue de littérature |
|
|
|
Muralidharan, G, Rao, et al |
Biomedical and Pharmacology Journal |
Review Literature| Revue de littérature |
|
|
|
Pagliari, F, Marafioti, et al |
Frontiers in Molecular Biosciences |
Review Literature| Revue de littérature |
|
|
|
D-dimer concentrations and covid-19 severity: A systematic review and meta-analysis |
Paliogiannis, P, Mangoni, et al |
Frontiers in Public Health |
Review Literature| Revue de littérature |
SR-MA: search in Medline (PubMed), Scopus and Web of Science was performed with no language restrictions. In conclusion,
our systematic review and meta-analysis showed that serum D-dimer concentrations in patients with severe COVID-19 are significantly higher when compared to those with non-severe forms. |
|
Animal Models for SARS-CoV-2 research: A Comprehensive Literature Review |
Pandey, K, Acharya, et al |
Transbound Emerg Dis |
Review Literature| Revue de littérature |
|
|
Park, R, Lee, et al |
Acta Oncol |
Review Literature| Revue de littérature |
SR-MA: search of databases (PubMed, Embase) was conducted for studies published from inception to July 1, 2020. Active
chemotherapy appears to be associated with higher risk of death in cancer patients with COVID-19.
|
|
|
Patra, Sinjini, Saxena, et al |
Research Square prepub |
Review Literature| Revue de littérature |
MA: Our study therefore offers probiotics mediated novel preventive and therapeutic strategy for COVID-19-warfare. |
|
|
COVID-19 and Corrections in Australia: A Summary Review of the Available Data
and Literature |
Payne, JL, Hanley, et al |
Victims and Offenders |
Review Literature| Revue de littérature |
|
|
Petrikov, SS, Kholmogorova, et al |
Counseling Psychology and Psychotherapy |
Review Literature| Revue de littérature |
|
|
|
Tracheotomy in the age of the COVID-19 pandemic: Up-to-date review |
Piatkowski, J, Klecha, et al |
Polish Otorhinolaryngology Review |
Review Literature| Revue de littérature |
|
|
Pieretti, JC, Rubilar, et al |
Virus research |
Review Literature| Revue de littérature |
|
|
|
Pietreanu, CV, Zaharia, et al |
INCAS Bulletin |
Review Literature| Revue de littérature |
|
|
|
Qureshi, RO, Kokkirala, et al |
R I Med J (2013) |
Review Literature| Revue de littérature |
|
|
|
Comorbidities and severity of coronavirus disease 2019 patients |
Radwan, NM, Mahmoud, et al |
Saudi Med J |
Review Literature| Revue de littérature |
|
|
Rahman, S, Singh, et al |
Therapeutics and Clinical Risk Management |
Review Literature| Revue de littérature |
|
|
|
Saberiyan, M, Safi, et al |
Clinical laboratory |
Review Literature| Revue de littérature |
|
|
|
Analyzing
the implications of COVID-19 on supply chain quality management |
Salimi, M, Sampaio, et al |
|
Review Literature| Revue de littérature |
|
|
Effects of COVID-19 pandemic on out-of-hospital cardiac arrests: A systematic
review |
Scquizzato, T, Landoni, et al |
Resuscitation |
Review Literature| Revue de littérature |
SR: searched PubMed, BioMedCentral, Embase and the Cochrane Central Register of Controlled Trials. ut-of-hospital
cardiac arrests had worse short-term outcomes during the pandemic than a non-pandemic period suggesting direct effects of COVID-19 infection and indirect effects from lockdown and disruption of healthcare systems. Patients at high risk of deterioration should
be identified outside the hospital to promptly initiate treatment and reduce fatalities. |
|
Blockchain technology and its applications to combat COVID-19 pandemic |
Sharma, A, Bahl, et al |
Research on Biomedical Engineering |
Review Literature| Revue de littérature |
|
|
Sieswerda, E, de Boer, et al |
Clinical Microbiology and Infection |
Review Literature| Revue de littérature |
|
|
|
Singh, N, Rai, et al |
Journal of chemical neuroanatomy |
Review Literature| Revue de littérature |
|
|
|
A Review of Domestic Violence against Women in India during Lockdown |
Singh, Suman, Bhattacharyya, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
|
|
Coronavirus disease and diabetes – interplay of two pandemics |
Subhadarsanee, C, Dhadse, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
|
|
Taanya, I, Abilasha, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
|
|
|
Tao, Z, Liu, et al |
Chinese Journal of Microbiology and Immunology (China) |
Review Literature| Revue de littérature |
|
|
|
State of fragility fractures management during the covid-19 pandemic |
Tarantino, U, Cariati, et al |
International Journal of Environmental Research and Public Health |
Review Literature| Revue de littérature |
|
|
Thute, PP, Bakane, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
|
|
|
Tokazhanov, G, Tleuken, et al |
Sustainability (Switzerland) |
Review Literature| Revue de littérature |
|
|
|
Trubin, PA, Azar, et al |
Current Transplantation Reports |
Review Literature| Revue de littérature |
|
|
|
On the whereabouts of SARS-CoV-2 in the human body: A systematic review |
Trypsteen, W, Van Cleemput, et al |
PLoS Pathog |
Review Literature| Revue de littérature |
SR: search on SARS-CoV-2 detection studies using the online databases PubMed, Web of Science and bioRxiv/medRxiv for
the time period January 1st 2020 until June 23rd 2020. The main SARS-CoV-2 entry receptor, ACE2, is expressed at different levels in multiple tissues throughout the human body, but its expression levels do not always correspond with SARS-CoV-2 detection, indicating
that there is a complex interplay between virus and host. |
|
Tsang, VHM, Gild, et al |
Endocr Relat Cancer |
Review Literature| Revue de littérature |
|
|
|
Udomsinprasert, W, Jittikoon, et al |
J Clin Immunol |
Review Literature| Revue de littérature |
SR-MA: PubMed, Scopus, and Cochrane Library and in a hand searching of reference lists from inception to July 31,
2020. Circulating levels of IL-6 and IL-10 might have great potential as biomarkers for the disease severity and mortality in COVID-19 patients. |
|
|
Surgical masks vs respirators for the protection against coronavirus infection: state
of the art |
Violante, T, Violante, et al |
Med Lav |
Review Literature| Revue de littérature |
|
|
The mental health of healthcare workers in the COVID-19 pandemic: A systematic
review |
Vizheh, M, Qorbani, et al |
Journal of Diabetes and Metabolic Disorders |
Review Literature| Revue de littérature |
SR: search conducted through e-databases, including PubMed, EMBASE, Scopus, and Web of Science (WoS) from December
2019 up to April 12th 2020. During SARS-CoV-2 outbreak, the health care workers face aggravated psychological pressure and even mental illness. It would be recommended to the policymakers and managers to adopt the supportive, encouragement & motivational,
protective, and training & educational interventions, especially through information and communication platform. |
|
Walsh, M |
Systematic Reviews in Pharmacy |
Review Literature| Revue de littérature |
SR: researcher extracted 64 articles, only 8 of which were reviews and all others were original clinical researches,
from medical databases including Pub Med, NIH and other clinical and scientific reports. The study can be concluded as suggesting that the herbal medicine is quite effective in helping to treat, prevent and cure viral infections and widespread viral diseases.
|
|
|
Wan, J, Wang, et al |
JGH Open |
Review Literature| Revue de littérature |
SR-MA: PubMed, Embase, Ovid, Wanfang data, and CNKI were searched until 24 April 2020. COVID-19 patients had a high
rate of digestive symptoms and liver injury. Patients with digestive symptoms had a trend to develop severe/critical illness. |
|
|
Communication Chaos from Discrepancies in Personal Protective Equipment and Preoperative
Guidelines |
Wang, N, Xu, et al |
Laryngoscope |
Review Literature| Revue de littérature |
|
|
The relationship between severe or dead COVID-19 and asthma: a meta-analysis |
Wang, Y, Ao, et al |
Clin Exp Allergy |
Review Literature| Revue de littérature |
SR-MA: systematically searched relevant studies in Pubmed, Cochrane library, Embase, Web of 42 Science, VIP Database
of Chinese periodicals, China National Knowledge Infrastructure (CNKI), from their inception up to September 1st, 2020 |
|
The use of social media and online communications in times of pandemic COVID-19 |
Wong, A, Ho, et al |
Journal of the Intensive Care Society |
Review Literature| Revue de littérature |
|
|
Yazhlini, P, Anjali, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
|
|
|
The roles of nausea and vomiting in COVID-19: did we miss something? |
Zhang, T, Liu, et al |
Journal of Microbiology, Immunology and Infection |
Review Literature| Revue de littérature |
|
|
Zheng, H, Hébert, et al |
British journal of anaesthesia |
Review Literature| Revue de littérature |
|
|
|
ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19 |
Zipeto, D, Palmeira, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
|
|
Zortea, TC, Brenna, et al |
Crisis |
Review Literature| Revue de littérature |
SR: searched MEDLINE, EMBASE, PsycInfo, CINAHL, Scopus, Web of Science, PsyArXiv, medRxiv, and bioRxiv from inception
to May 13-16, 2020. Findings support an association between previous epidemics and increased risk of suicide-related outcomes. |
|
|
Abba Ahmed, Bello |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Abdelfattah, D |
Prim Care Companion CNS Disord |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Abdelhamid, K, ElHawary, et al |
AEM Education and Training |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 and WHO: Global institutions in the context of shifting multilateral and
regional dynamics |
Agartan, TI, Cook, et al |
Global Social Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 pandemic preparedness: A practical guide from clinical pharmacists' perspective |
Ahuja, T, Merchan, et al |
American Journal of Health-System Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
What is the long-term clinical significance of anti-SARS-CoV-2-specific IgG? |
Alberca, GGF, Alberca, et al |
Influenza Other Respir Viruses |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Aldinhas Ferreira, MI |
Intelligent Systems, Control and Automation: Science and Engineering |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Aldinhas Ferreira, MI |
Intelligent Systems, Control and Automation: Science and Engineering |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Smart City: The Exponent of a Civilization Transition in the Context of a
Global Crisis |
Aldinhas Ferreira, MI |
Intelligent Systems, Control and Automation: Science and Engineering |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 pandemic and total mortality in the first six months of 2020 in Italy |
Alicandro, G, Remuzzi, et al |
Med Lav |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Alter, G, Seder, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Alves, MA, da Costa, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Implications of the covid-19 pandemic on funding basic education |
Alves, T, Farenzena, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
An, Y |
Educational Technology Research and Development |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Anderton, CH |
Peace Economics, Peace Science and Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Civil society mobilization in coping with the effects of covid-19 in Brazil |
Andion, C |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 and antimalarials. Have we been doing it wrong all along? |
Andrei, CC, Laurentiu, et al |
Eur J Pharmacol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Araujo-Filho, J, Normando, et al |
Jornal Brasileiro de Pneumologia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Changes
in patient behavior during COVID-19: What I've observed |
Arbuck, D |
Current Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Multisystem Inflammatory Syndrome in Children in the United States |
Arditi, M, Bahar, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lessons learned from COVID-19: the radiologist's point of view |
Arenas-Jiménez, JJ, Gorospe Sarasúa, et al |
Radiologia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Argento, D, Kaarbøe, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32916249; Integrated control of COVID-19 in resource-poor countries |
Aziz, AB, Raqib, et al |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Azzi, L, Maurino, et al |
J Dent Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Quality insight: Exponential decay of quality learning curves during COVID-19 lockdown |
Badiru, A |
International Journal of Quality Engineering and Technology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Baik, CH |
International Bulletin of Mission Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Baker, A, Brogan, et al |
Review of Industrial Organization |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33078764; Use of protective partition during extubation in the COVID-19 pandemic |
Bakshi, SG, Trivedi, et al |
Indian journal of cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Balocco, C, Leoncini, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bao, Y, Shen, et al |
Nonprofit and Voluntary Sector Quarterly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Barry, K, McCarthy, et al |
R I Med J (2013) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Haematological manifestations of COVID 19 and their prognostic significance-a
cross-sectional study |
Bawiskar, N, Andhale, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bekker-Nielsen Dunbar, M, Held, et al |
Revstat Statistical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ben Zayed, S, Gani, et al |
Studies in Systems, Decision and Control |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 in men: With or without virus in semen, spermatogenesis may be impaired |
Bendayan, M, Robin, et al |
Andrologia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bernabe-Ramirez, C, Velazquez, et al |
Cancer Cell |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A historical insight into an announced tragedy: COVID-19 pandemic |
Bestetti, RB, Freitas, et al |
Int J Clin Pract |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Between Crisis and Convention: How Should We Address Contingency? |
Bibler, T |
Hastings Center Report |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Blanchet, K, Alwan, et al |
BMJ Global Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
At TDAG-2020, let's seize the momentum to build
back better after COVID-19 |
Bogdan-Martin, D |
ITU News |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bonora, BM, Morieri, et al |
Diabetes care |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Booz, GW, Zouein, et al |
Eur J Pharmacol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Boštíková, V, Pejchalová, et al |
Vakcinologie |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Botti, F, Mazza, et al |
Digestive and Liver Disease |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The COVID-19 pandemic presents an opportunity to develop more sustainable health
workforces |
Bourgeault, IL, Maier, et al |
Hum Resour Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bove, V, Di Leo, et al |
Peace Economics, Peace Science and Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Emerging threats linking tropical deforestation and the COVID-19 pandemic |
Brancalion, PHS, Broadbent, et al |
Perspectives in Ecology and Conservation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Responses Taken to Mitigate COVID-19 in Prisons in England and Wales |
Brennan, PK |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Brion, LP, Chan, et al |
Am J Obstet Gynecol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33077985; The use of facial masks: updated information after Covid-19 |
Brugnolli, A, Prosperi, et al |
Assistenza Infermieristica e Ricerca : AIR |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bruni, T, Lalvani, et al |
American journal of respiratory and critical care medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Burkett, E, Carpenter, et al |
Emerg Med Australas |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33078004; Bureaucracy gives way to science. What good the pandemic has left |
Cagnazzo, C, Fagioli, et al |
Recenti progressi in medicina |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Exams tested by Covid-19: An opportunity to rethink standardized senior secondary
examinations |
Cairns, R |
Prospects |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pediatric Eye Care: We Cannot Lose Sight of Its Importance despite the COVID-19
Pandemic |
Camhi, SS, Shah, et al |
J Binocul Vis Ocul Motil |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Paramedic delivery of bad news: a novel dilemma during the COVID-19 crisis |
Campbell, I |
J Med Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Capodeferro, MW, Smiderle, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Stigma-discrimination: Significant collateral damage of COVID-19 |
Cassiani-Miranda, C, Campo-Arias, et al |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Castaldi, M, Latifi, et al |
Am Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 and the potential consequences for social stability |
Censolo, R, Morelli, et al |
Peace Economics, Peace Science and Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Černá Pařízková, R, Dostál, et al |
Anesteziologie a Intenzivni Medicina |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chahal, K |
Current Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Outcomes of Patients on Maintenance Dialysis Hospitalized with COVID-19 |
Chan, L, Jaladanki, et al |
Clin J Am Soc Nephrol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pandemic COVID-19: Current status and challenges of antiviral therapies |
Chan, W, He, et al |
Genes and Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gendering COVID-19: Impact of the Pandemic on Women’s Burden of Unpaid Work in
India |
Chauhan, P |
Gender Issues |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Chen, M, Mu, et al |
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chen, SCA, Rawlinson, et al |
Pathology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chlíbek, R |
Vakcinologie |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Optimizing teledermatology: looking beyond the COVID-19 pandemic |
Choi, E, Mak, et al |
Int J Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Choolayil, AC, Putran, et al |
South Asia Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chotpitayasunondh, T, Fischer, et al |
Influenza Other Respir Viruses |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chou, WS, Budenz, et al |
Health Commun |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Infodemics during COVID-19: resources and recommendations to combat it |
Cifuentes-Faura, J |
Online Information Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Clark, JL |
Hearing Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Clement, KD, Zimmermann, et al |
BMJ Innovations |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The public administration’s ‘engine room’ in the fight against covid-19 |
Coelho, FS, Corrêa, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Comba, JLD |
Computing in Science and Engineering |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cordon-Cardo, C, Pujadas, et al |
Cancer Cell |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Corradini, P, Gobbi, et al |
HemaSphere |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Correia, PMAR, Mendes, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Costa, SDS |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cote, MP, Donne, et al |
Medical reference services quarterly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cotton, SA, Roche, et al |
Am J Crit Care |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Employee Assistance Program response and evolution in light of COVID-19 pandemic |
Couser, GP, Nation, et al |
Journal of Workplace Behavioral Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cram, F |
MAI Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Say what?! Ableist logic used in misguided attempt to combat ageism during COVID-19 |
Cruise, C, Lashewicz, et al |
J Am Geriatr Soc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cueto, M |
Historia, Ciencias, Saude - Manguinhos |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Čupić, Milan |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Czeisler, MÉ, Garcia-Williams, et al |
Morbidity and Mortality Weekly Report |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The art of the possible in approaching efficacy trials for COVID19 convalescent
plasma |
Daniele, F, Albert, et al |
Int J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Accelerated research for COVID-19: Methodological ruminations
for internet-based research |
Das, A |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Das, D, Lall, et al |
AEM Education and Training |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
de Amorim, ALB, Ribeiro Junior, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Increase of stillbirth and decrease of late preterm infants during the COVID-19
pandemic lockdown |
De Curtis, M, Villani, et al |
Arch Dis Child Fetal Neonatal Ed |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Prioritizing COVID-19 vaccination for people with severe mental illness |
De Hert, M, Mazereel, et al |
World Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
De Stefano, L, Bobbio-Pallavicini, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
de Wijs, LEM, Joustra, et al |
J Eur Acad Dermatol Venereol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Degerman, D, Flinders, et al |
Critical Review of International Social and Political Philosophy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19 and the Apocalypse: Religious and Secular Perspectives |
Dein, S |
J Relig Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Non-infectious status indicated by detectable IgG antibody to SARS-CoV-2 |
Denning, DW, Kilcoyne, et al |
British dental journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
DeSarbo, JR, DeSarbo, et al |
Current Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Deshmukh, AS, Rathi, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Dhandapani, M, Kaur, et al |
Infect Dis (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
HVAC systems for environmental control to minimize the COVID-19 infection |
Ding, J, Yu, et al |
Indoor and Built Environment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Diwambuena, Josue, Musimwa, et al |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Doan, BT, Yang, et al |
Journal of Contemporary Psychotherapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Maintaining critical infrastructure safety during the Covid-19 pandemic |
Doherty, M |
Proceedings of the Institution of Civil Engineers: Civil Engineering |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Prepandemic Preparedness under the Spotlight at ASGCT's COVID-19 Symposium |
Dolgin, E |
Molecular Therapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
33084496; COVID-19 and the Case for Medical Management and Primary Care |
Dominguez, LW, Willis, et al |
Journal of Primary Care and Community Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Building on innovation and lessons learnt during the COVID-19 pandemic |
Dooley, M |
Journal of Pharmacy Practice and Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Antivirale middelen
mogelijk in vroeger stadium COVID-19 toepassen |
Dorlo, TPC, Heine, et al |
Pharmaceutisch weekblad |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ebrahim, SH, Gozzer, et al |
Int J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Eichfelder, S, Hoke, et al |
Wirtschaftsdienst |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ekezie, W, Czyznikowska, et al |
J Public Health (Oxf) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19: Reflecting on the role of the WHO in knowledge exchange between the Global
North and South |
Ekpenyong, A, Pacheco, et al |
Global Social Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
How the COVID-19 Pandemic Will Make Us Better Future Physicians |
ElHawary, H, Salimi, et al |
AEM Education and Training |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Enari, D, Matapo, et al |
MAI Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Adapting the EU Economic Governance to New Macroeconomic and Political Realities |
Fargnoli, R |
Intereconomics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Multisystem Inflammatory Syndrome in Children in the United States. Reply |
Feldstein, LR, Rose, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Fernandes, GAAL, Pereira, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ferreira, E, Alves, et al |
Arquivos Brasileiros de Cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Care goes viral: Care theory and research confront the global covid-19 pandemic |
Fine, M, Tronto, et al |
International Journal of Care and Caring |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Fatality and risk factors for severe courses of COVID-19 pneumonia |
Flick, H |
Pneumologe |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19: a potential driver of immune-mediated breast cancer recurrence? |
Francescangeli, F, De Angelis, et al |
Breast Cancer Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Besides the
expansion of telemedicine, how has the COVID-19 pandemic affected your practice? |
Freedman, S, Kuhr, et al |
Urology Times |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Freites Nuñez, DD, Leon, et al |
Ann Rheum Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33077943; All eyes on a hurdle race for a SARS-CoV-2 vaccine |
Gaebler, C, Nussenzweig, et al |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ignorance is not bliss: managing uncertainty in acute stroke treatment in the COVID-19
era |
Ganesh, A, Ospel, et al |
Neuroradiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sensitive mass spectrometric determination of kinin-kallikrein system peptides
in light of COVID-19 |
Gangnus, Tanja, Burckhardt, et al |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
|
|
García Clemente, M, Madrid Carbajal, et al |
Archivos de Bronconeumologia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7597579; Cardiology and COVID-19: do we have sufficient information? |
Garg, N, McClafferty, et al |
Future Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A Survey on how computer vision can response to urgent need to contribute in
COVID-19 pandemics |
Gazzah, S, Bencharef, et al |
2020 International Conference on Intelligent Systems and Computer Vision, ISCV 2020 |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gennaro, N, Marrari, et al |
Clinical imaging |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Sincerest Form of Flattery: Nationalist Emulation during the COVID-19 Pandemic |
Givens, JW, Mistur, et al |
Journal of Chinese Political Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Obduktionen bei COVID-19 Pathologische Veränderungen und Organmanifestationen |
Goebels, H, Edler, et al |
Klinikarzt |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The European economic constitution after the PSPP judgment: Towards integrative liberalism? |
Goldmann, M |
German Law Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gomes, MGM |
Revstat Statistical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Digital complementary currencies and public policies during the covid-19 pandemic |
Gonzalez, L, Cernev, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gosselin, JulieS, Godbout, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Noncoding RNAs implication in cardiovascular diseases in the COVID-19 era |
Greco, S, Madè, et al |
J Transl Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Comments on psychological impact of COVID-19 lockdown: An online
survey from India |
Grover, S, Sahoo, et al |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Grover, S, Sinha, et al |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Guerra, S, Salinas, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Gulrandhe, P, Sahu, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Gupta, R |
Crit Care |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Let's build the psychological immunity to fight against COVID-19 |
Gupta, T, Nebhinani, et al |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gutmann, EJ |
Cancer Cytopathol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rethinking democratic theories of justice in the economy after COVID-19 |
Haagh, L |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The U.S. High-Performance Computing Consortium in the Fight against COVID-19 |
Hack, JJ, Papka, et al |
Computing in Science and Engineering |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19: Large-scale collective action, government intervention, and the importance
of trust |
Harring, N, Jagers, et al |
World Development |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Innovation in wastewater near-source tracking for rapid identification of COVID-19
in schools |
Hassard, Francis, Lundy, et al |
The Lancet Microbe |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Reflections on the Stability and Growth Pact’s Preventive Arm in Light of the COVID-19
Crisis |
Hauptmeier, S, Leiner-Killinger, et al |
Intereconomics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hawkes, S, Buse, et al |
Canadian Journal of Development Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19: a fork in the road ahead for general practice or a knife severing the road behind? |
Heer-Stavert, S |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Heinz, FX, Stiasny, et al |
Wien Klin Wochenschr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Herrero, TV |
AMA Journal of Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Heymann, WR |
J Am Acad Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hightower, S, Ellis, et al |
Thromb Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Is it time for dermatologists to review our professional consumer-brand relationships? |
Ho, B, Mansoor, et al |
J Cosmet Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Online Activities of Croatian Public Libraries During COVID-19 Spring Lockdown |
Holcer, D |
International Information and Library Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
An exploration of online Christian faith nurture for children, using UK churches
as a case study |
Holmes, SE |
International Journal of Christianity and Education |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Role of vitamin D in pathogenesis and severity of COVID-19 infection |
Honardoost, M, Ghavideldarestani, et al |
Arch Physiol Biochem |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Honorato, BEF, Oliveira, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A Postcard from the COVID-19 Crisis Response: Lessons and Opportunities for Remediation |
Horst, J, Welty, et al |
Groundwater Monitoring and Remediation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Horton, R |
Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Self-care strategies in response to nurses' moral injury during COVID-19 pandemic |
Hossain, F, Clatty, et al |
Nurs Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hosseini, A, Bahramnezhad, et al |
Sao Paulo Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hrabok, M, Nwachukwu, et al |
Can J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nurses’ Sleep Quality of “Fangcang” Hospital in China during the COVID-19 Pandemic |
Huang, L, Lei, et al |
International Journal of Mental Health and Addiction |
Commentary/Editorial| Commentaire/Éditorial |
|
|
United States Bureau of Prisons’ Response to the COVID-19 Pandemic |
Hummer, D |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ismail, AM, Elfiky, et al |
Signal Transduct Target Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ito, NC, Pongeluppe, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Specificity and cross-reactivity of a test for anti-SARS-CoV-2 antibodies –
Authors' reply |
Iversen, Kasper, Bundgaard, et al |
The Lancet Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Far apart, yet close together: Cooperative learning in online education |
Ivone, FM, Jacobs, et al |
Studies in English Language and Education |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Adult education in times of the COVID-19 pandemic: Inequalities, changes, and
resilience |
James, N, Thériault, et al |
Studies in the Education of Adults |
Commentary/Editorial| Commentaire/Éditorial |
|
|
James, RI, Kumar, et al |
Journal of South India Medicolegal Association |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Jameson, JM, Stegenga, et al |
Rural Special Education Quarterly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Jeevan, J, Mohd Salleh, et al |
Australian Journal of Maritime and Ocean Affairs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Proclamation of Charles H. Long in the Time of Black Live Matter, Standing Rock, and
COVID-19 |
Jefferson-Tatum, E |
Dialog |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ji, D, Cheng, et al |
J Hepatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Jia, YP, Cao, et al |
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Jian, Y, Yu, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33076589; World Health Organization's response mechanisms for COVID-19 |
Jing, WZ, Liu, et al |
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Johnson, AR, McDonald, et al |
J Foot Ankle Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33073939; COVID-19 PCR Test, Cluster of False Positive and Importance of Quality
Control |
Joob, B, Wiwantikit, et al |
Clinical laboratory |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Joshi, KG |
Current Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shifting baselines and political expediency in New Zealand's freshwater management |
Joy, MK, Canning, et al |
Marine and Freshwater Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Trustworthy COVID-19 Mapping: Geo-spatial Data Literacy Aspects of Choropleth Maps |
Juergens, C |
KN - Journal of Cartography and Geographic Information |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kameno, Y, Hanada, et al |
Psychiatry Clin Neurosci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Post-mortem ultrasonography: a safer alternative to autopsies in COVID-19 deaths |
Kanchan, T, Shrestha, et al |
J Ultrasound |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kar, SK, Menon, et al |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hydroxychloroquine for coronavirus: how not to repurpose a drug during a pandemic |
Karunajeewa, H |
Intern Med J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Intricate interplay between Covid-19 and cardiovascular diseases |
Keri, VC, Hooda, et al |
Rev Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Building resilience in the COVID-19 era: Three paths in the bhagavad
gita |
Keshavan, MS |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
SARS-CoV-2: Pathogenesis, and Advancements in Diagnostics and Treatment |
Khalaf, K, Papp, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ivermectin Treatment May Improve the Prognosis of Patients With COVID-19 |
Khan, MSI, Khan, et al |
Archivos de Bronconeumologia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Khurana, A |
Indian Journal of Research in Homoeopathy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Artificial intelligence in medicine and the disclosure of risks |
Kiener, M |
AI and Society |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kiesewetter, H |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kim, CNH, Hutcheon, et al |
Am J Obstet Gynecol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33077454; Managing type 2 diabetes in primary care during COVID-19 |
Kiran, T, Moonen, et al |
Canadian family physician Medecin de famille canadien |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kirby, Tony |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kishi, T, Mizuno, et al |
Circulation Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kittel, B, Kritzinger, et al |
European Political Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Klein, F |
Pneumologie |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The toll of noninfected CRS patients to the COVID-19 pandemic |
Klimek, L, Hagemann, et al |
Rhinology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
US election: How covid-19 pushed doctors into the political arena like never before |
Knight, V |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kniss, DA |
Am J Obstet Gynecol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19 as a potential accelerator. A euro-centric perspective |
Kollias, C, Zouboulakis, et al |
Peace Economics, Peace Science and Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Krome, S |
Pneumologie |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Management
of a "suspected ward" in a COVID-19 designated hospital in Wuhan |
Kuang, M, Zheng, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kuitunen, I, Haapanen, et al |
Acta Paediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33078765; Barrier devices for aerosol-generating procedure during COVID-19 pandemic |
Kumar, V, Gupta, et al |
Indian journal of cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Intensive care unit‐acquired weakness: Not just another muscle atrophying condition |
Lad, H, Saumur, et al |
International Journal of Molecular Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19:
How the telecoms industry can help keep everyone connected: Opinion |
Lamanauskas, T |
ITU News |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Role of An Academic Emergency Department in Advancing Equity and Justice |
Landry, AM, Brown, et al |
Acad Emerg Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lavigne, SE |
Canadian Journal of Dental Hygiene |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33078024; Case reports of first psychiatric presentations during CoViD-19 pandemic |
Lazzari, C, Nusair, et al |
Rivista di psichiatria |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lazzarini, SG, Musacchio, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Leal, CIS |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
More Than Inconvenienced: The Unique Needs of U.S. College Students During the COVID-19
Pandemic |
Lederer, AM, Hoban, et al |
Health Educ Behav |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lee, TC, Butler-Laporte, et al |
Clinical Microbiology and Infection |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
CoviD-19: Public access to information – Legal and institutional frameworks |
Lee, YS, Mun, et al |
Law and Development Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 response exposes deep flaws in global health governance |
Legge, DG |
Global Social Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 Research: Women Are Changing the Face of the Pandemic |
Lemieux, JP |
Genetic Engineering and Biotechnology News |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Leone, D, Borghi, et al |
Recenti progressi in medicina |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Multisystem Inflammatory Syndrome in Children in the United States. Reply |
Levin, M |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Levine, P |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Preparing a deployed role 3 medical treatment facility for COVID-19 in Afghanistan |
Lewin, IJS, Krasucki, et al |
BMJ Mil Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Li, M |
European Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Li, W |
Qualitative Inquiry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Liao, S, Zhan, et al |
Signal Transduct Target Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Incomplete contracts for bus service during the covid-19 pandemic |
Lima, GCLS, de Carvalho, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Auswirkungen der Pandemie: Gesundheitskrise, Ökonomie und Ungleichheit |
Linden, M |
Geographica Helvetica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lippi, G, Sanchis-Gomar, et al |
J Diabetes |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lipscy, PY |
International Organization |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Liu, A |
Rambam Maimonides Med J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lobzin, YV, Cherkashina, et al |
Voprosy Prakticheskoi Pediatrii |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
López-Díaz, Á, Ayesa-Arriola, et al |
Biol Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Luka, ME |
Qualitative Inquiry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7252030; The Topic of COVID-19-Related Liver Injury Needs More Rigorous Research |
Lv, XH, Yang, et al |
Clin Gastroenterol Hepatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Macioce, F |
Actualidad Juridica Iberoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Magaço, A, Munguambe, et al |
Glob Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Magoon, R |
J Anesth |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 and Supply Chain Disruption: Evidence from Food Markets in India† |
Mahajan, K, Tomar, et al |
American Journal of Agricultural Economics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mahalmani, VM, Semwal, et al |
Indian Journal of Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mahase, E |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Precarious Sovereignty in a Post-liberal Europe: The COVID-19 Emergency in Estonia
and Finland |
Makarychev, A, Romashko, et al |
Chinese Political Science Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Manickam, S, Slingsby, et al |
R I Med J (2013) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
May SARS-CoV-2 Diffusion be favored by Alkaline Aerosols and Ammonia Emissions? |
Manigrasso, M, Protano, et al |
Atmosphere |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7443159; A Novel Protocol for Very Early Hospital Discharge After STEMI |
Marbach, JA, Alhassani, et al |
Can J Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A Simple Method for Safer Flexible Fiberoptic Laryngoscopy in the Era of COVID-19 |
Maroun, CA, Faddoul, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Marshall, S, Duryea, et al |
Am J Orthod Dentofacial Orthop |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
First, Do No Harm: Caution Against Use of Tocilizumab in COVID-19 |
Mastroianni, F |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Masurkar, D, Jaiswal, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Neuropathologische Veränderungen bei COVID-19 Aktuelle Erkenntnisse |
Matschke, J, Hagel, et al |
Klinikarzt |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Maurya, SP, Das, et al |
Indian Journal of Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Severe acute respiratory distress syndrome secondary to coronavirus 2 (SARS-CoV-2) |
Maveddat, A, Mallah, et al |
International Journal of Occupational and Environmental Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gendered experiences of leading and managing through COVID-19: patriarchy and precarity |
Mavin, S, Yusupova, et al |
Gender in Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Resourcing primary care to tackle covid-19: cooperation, not competition |
McAnea, TC |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 Test Result Turnaround Time for Residents and Staff in US Nursing
Homes |
McGarry, BE, SteelFisher, et al |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
McKiever, ME, Cleary, et al |
Am J Obstet Gynecol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
An Indigenous self-determination social movement response to COVID-19 |
McMeeking, S, Leahy, et al |
AlterNative |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Medeiros, BP, Goldoni, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mehta, CK, Malaisrie, et al |
Asian Cardiovasc Thorac Ann |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Melo, C, Cabral, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Menapace, LA, Thein, et al |
Haematologica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mendoza, E |
Phlebologie |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 pandemic and implications for graduate medical training |
Menon, V, Padhy, et al |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Michie, J |
International Review of Applied Economics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Michie, S, West, et al |
Br J Health Psychol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A virtual community health field project during the COVID-19 pandemic |
Miller, CE, Benton, et al |
J Dent Educ |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mills, G |
Veterinary Record |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
In the response to COVID-19, children
are key and part of the solution |
M'Jid, M |
ITU News |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Monchalin, R |
Women's Health Issues |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Morando, JM |
ITU News |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Moscara, M, Mattei, et al |
Recenti progressi in medicina |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sports Medicine Australia and COVID-19: Providing 'virtual' support to the sports
community |
Mosler, AB, West, et al |
British journal of sports medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Moudgalya, KM |
Lecture Notes in Educational Technology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mrityunjaya, M, Pavithra, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Murphy, K |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Muzio, D, Doh, et al |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nallamothu, BK |
Circ Cardiovasc Qual Outcomes |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Educational concerns of children with disabilities during COVID-19
pandemic |
Narvekar, HN |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cardiac troponin as a predictor of myocardial injury and mortality from COVID-19 |
Nascimento, JHP, Gomes, et al |
Arquivos Brasileiros de Cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ndlovu-Gatsheni, S |
Journal of Developing Societies |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nesrallah, G, Gilmour, et al |
Canadian Journal of Kidney Health and Disease |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7282779; Potential challenges in managing obstetrical patients with coronavirus
disease 2019 |
Ng Yin, K, Lee, et al |
Am J Obstet Gynecol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ng, MY, Ferreira, et al |
JACC: Cardiovascular Imaging |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Diversifying the biomedical workforce during the COVID-19 pandemic |
Nguyen, LH, Tan-McGrory, et al |
Nat Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hiv, COVID-19, and civil society: Lessons from venezuela’s humanitarian crisis |
Nieves, A, Safreed-Harmon, et al |
AIDS Reviews |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Institutional Responses to the COVID-19 Pandemic in American Prisons |
Novisky, MA, Narvey, et al |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nunes, B, Caetano, et al |
Revstat Statistical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 pandemic: Euphemism and dysphemism in jordanian arabic |
Olimat, SN |
GEMA Online Journal of Language Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Why effective disaster management needs enabling policy environments:
Lessons from COVID-19 |
Oloyede, A |
ITU News |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Contextual reflections on COVID-19 and informal workers in Nigeria |
Omobowale, AO, Oyelade, et al |
International Journal of Sociology and Social Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Panizzon, M, da Costa, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Papa, A, Papa, et al |
Therapeutic Advances in Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Insights for air quality management from modeling and record studies in Cuenca, Ecuador |
Parra, R, Espinoza, et al |
Atmosphere |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Parthasarathy, S |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pata, F, Khan, et al |
J Trauma Acute Care Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Patel, R, DeWaters, et al |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Patel, VV, Beil, et al |
AIDS Reviews |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7518168; Rising to the Challenge: Otolaryngologists in the COVID-19 Pandemic |
Patel, ZM |
Otolaryngol Clin North Am |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pearlman, A, Troesch, et al |
Urology Times |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The response of the brazilian public administration to the challenges of the covid-19
pandemic |
Peci, A |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Penninger, JM, Grant, et al |
Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Fear of death and polarization: Political consequences of the covid-19 pandemic |
Pereira, C, Medeiros, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Perez de Tudela, EM |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
SARS-CoV-2 spike protein: flexibility as a new target for fighting infection |
Pierri, CL |
Signal Transduct Target Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Letter to the Editor Re: Global perspective of COVID-19 epidemiology for a full-cycle pandemic |
Pilz, S |
Eur J Clin Invest |
Commentary/Editorial| Commentaire/Éditorial |
|
|
33085949; Compassionate Computing in the Time of COVID-19: Interview with Laurie
N. Taylor |
Pomputius, A |
Medical reference services quarterly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Prainsack, B |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Prentice, RE, Al-Ani, et al |
Digestive and Liver Disease |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Will COVID-19 be the coming of age for point-of-care testing? |
Price, CP, St John, et al |
BMJ Innovations |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Qian, X |
International Social Security Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Quazi, AA, Patil, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation |
Rahikainen, R, Rijal, et al |
Angewandte Chemie - International Edition |
Commentary/Editorial| Commentaire/Éditorial |
|
|
33078758; Metronomic chemotherapy for scheduling oral cancer surgery during the COVID-19
pandemic |
Rajan, S, Kumar, et al |
Indian journal of cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
‘A Long Battle Ahead’: Malaysian and Singaporean Prime Ministers Employ War Metaphors
for COVID-19 |
Rajandran, K |
GEMA Online Journal of Language Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ramirez, AV |
AMA Journal of Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ramiro, S, Landewé, et al |
Ann Rheum Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Art of medicine indigenous apocalypse and transgenerational trauma |
Ramos, S |
AMA Journal of Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rana, RE, Khan, et al |
Int J Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Destinations Matter: Social Policy and Migrant Workers in the Times of Covid |
Rao, N, Narain, et al |
European Journal of Development Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19 and entrepreneurship education: Implications for advancing research and
practice |
Ratten, V, Jones, et al |
International Journal of Management Education |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Entrepreneurship and management education: Exploring trends and gaps |
Ratten, V, Jones, et al |
International Journal of Management Education |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Raveh, Y, Simkins, et al |
Am J Transplant |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ravi, SanjanaJ, Warmbrod, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Reilly, P |
Genetic Engineering and Biotechnology News |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Competitive Sports, the Coronavirus Disease 2019 Pandemic, and Big Ten Athletics |
Rink, LD, Daniels, et al |
Circ Cardiovasc Qual Outcomes |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Roberts, G |
Clin Exp Allergy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pandemic responses in vulnerable communities: A simulationoriented approach |
Rodrigues, VP, de Oliveira, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Intensivmedizin und COVID-19 Beatmung, Organversagen und Stellenwert von Obduktionen |
Roedl, K, Kluge, et al |
Klinikarzt |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rohner, D |
Peace Economics, Peace Science and Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Babies and boomers intergenerational democracy and the political epidemiology of COVID-19 |
Rollo, T |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rossella, E, Giuseppe, et al |
J Plast Reconstr Aesthet Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rothschild, E, Baruch, et al |
JACC: Cardiovascular Imaging |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19 and Our Understanding of Risk, Emergencies, and Crises |
Rouleau, L, Hällgren, et al |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rousseau, C, Miconi, et al |
J Am Acad Child Adolesc Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Gender, leadership and representative democracy: The differential impacts of the global
pandemic |
Rubenstein, K, Bergin, et al |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ruiy, W, Hsu, et al |
J Formos Med Assoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Saadh, MJ, Bashar Haj Rashid, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Precedent of Good Enough Therapy During Unprecedented Times |
Saidipour, P |
Clinical Social Work Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The food acquisition program (Paa) as a strategy to face the challenges of covid-19 |
Sambuichi, RHR, de Almeida, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Samouh, Y, Benider, et al |
Medecine Therapeutique |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ranting during the pandemic: Online contributions to our online world |
Samuels, A |
Psychotherapy and Politics International |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Moral dilemmas of the Brazilian public management in the face of the covid-19 pandemic |
Santos, LS |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sapiro, A, Antonello, et al |
Scientia Medica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Scauso, MS, FitzGerald, et al |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Children and COVID-19: addressing the mental health impact of the pandemic |
Schiavo, R |
Journal of Communication in Healthcare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Schinkel, M, Virk, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Schmidt, Harald, Unver, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Scholz, JR, Lopes, et al |
Arquivos Brasileiros de Cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Schulze-Koops, H, Skapenko, et al |
Ann Rheum Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Scott-Sheldon, L, Gathright, et al |
R I Med J (2013) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Establishing clinical pharmacist telehealth services during the COVID-19 pandemic |
Segal, EM, Alwan, et al |
American Journal of Health-System Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cardiac Involvement in the COVID-19 Pandemic: Hazy Lessons From Cardiac Imaging? |
Sengupta, PP, Chandrashekhar, et al |
JACC: Cardiovascular Imaging |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Shah, S, Yang, et al |
Neurosurg Focus |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sharma, N, Soni, et al |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
ITU-WHO-UNICEF initiative delivers
vital information on COVID-19 |
Sharma, S |
ITU News |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sharrma, A, Baqir, et al |
ITU News |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shenoi, S, Hayward, et al |
Pediatr Rheumatol Online J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Conflicting Impact of COVID-19’s Health and Economic Crises on Helping |
Shoss, MK, Horan, et al |
Group and Organization Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Psychological impact of COVID-19 lockdown: An online survey from
India: Few concerns |
Shukla, A |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Comment on psychological impact of COVID-19 lockdown: An online
survey from India |
Singh, GP |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The need for routine psychiatric assessment of COVID-19
survivors |
Singh, OP |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Siu, JY |
Health Soc Care Community |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Developing inclusive and resilient systems: COVID-19 and assistive technology |
Smith, EM, MacLachlan, et al |
Disability and Society |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sommer, AP, Försterling, et al |
Drug Res (Stuttg) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sorscher, SM |
Cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Trauma-informed pedagogy for the religious and theological higher education classroom |
Stephens, DW |
Religions |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19:
Deloitte's revised key tech, media and telecom predictions 2020 |
Stewart, D |
ITU News |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sugalski, J, Franco, et al |
J Natl Compr Canc Netw |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Multi-dimensional effects of the COVID-19 pandemic considering the WHO's ecological
approach |
Tabari, P, Amini, et al |
Glob Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tavabie, OliverD, Abeysekera, et al |
The Lancet Gastroenterology & Hepatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ace2 expression and risk factors for covid-19 severity in patients with advanced age |
Tavares, CAM, Avelino-Silva, et al |
Arquivos Brasileiros de Cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32813847; Trends in peruvian scientific publications on COVID-19: A bibliometric
analysis |
Tellez, VA, Tellez, et al |
Sao Paulo Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tewari, Naveen, Kumar, et al |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Thakre, P, Naqvi, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Lancet Respiratory, Medicine |
Lancet Respir Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33078759; Impact of COVID-19 on cancer screening by Non-Government Organizations and
the way forward |
Thirthahalli, C, Shetty, et al |
Indian journal of cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Thornton, M, Reid, et al |
Anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Thwaites, RS |
Clin Exp Immunol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33077984; When, how, why and whom for there will be an "after" Covid-19? |
Tognoni, G |
Assistenza Infermieristica e Ricerca : AIR |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tralongo, AC, Extermann, et al |
J Geriatr Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Safeguarding cancer research funding by European charities amidst the COVID-19 pandemic |
Tsagakis, I, Papatriantafyllou, et al |
Mol Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Van Der Gronde, T, Pieters, et al |
Pharmaceutisch weekblad |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Immunoassays for anti-SARS-CoV-2 antibodies: recent insights |
Van Elslande, Jan, André, et al |
The Lancet Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
van Kruijsdijk, RC, de Jong, et al |
BMJ Case Rep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Vasavda, C, Ho, et al |
Medical Science Educator |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Photoinactivation of the Coronavirus Surrogate phi6 by Visible Light |
Vatter, P, Hoenes, et al |
Photochem Photobiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
An enhanced,
contactless, IoT based operation of power appliances for Covid -19 isolation zone |
Venusamyand, K, Basha, et al |
Journal of Green Engineering |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Adaptations to COVID-19 in Community Corrections Agencies across the United
States |
Viglione, J, Alward, et al |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Vivas, EX |
Otolaryngol Clin North Am |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Wagner, J, Ambrosy, et al |
Eur J Heart Fail |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Letter in Reply: Toward a COVID-19 Vaccine Strategy for Pemphigus Patients on Rituximab |
Waldman, RA, Creed, et al |
J Am Acad Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wasilewska-Ostrowska, K |
International Social Work |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 and liver transplantation: the jury is still out – Authors' reply |
Webb, GwilymJ, Marjot, et al |
The Lancet Gastroenterology & Hepatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Weeks, A, Houk, et al |
Medical reference services quarterly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Weinstein, RS, Holcomb, et al |
Telemed J E Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Werlein, C, Braubach, et al |
Klinikarzt |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Westermann, D, Lindner, et al |
Klinikarzt |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Westgren, M, Acharya, et al |
Am J Obstet Gynecol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Wiech, T, Sperhake, et al |
Klinikarzt |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Privatized Public Health Insurance and the Goals of Progressive Health Reform |
Wiley, Lindsay Freeman |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wiwanitkit, V |
Endoscopy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Wolf, A |
Wirtschaftsdienst |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7567519; A call for Essays: stories from the frontline during the COVID-19
pandemic |
Woolven, S |
Lancet Respir Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wormser, GP |
Wien Klin Wochenschr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Incorporating teleoncology practices in the undergraduate medical curriculum |
Wozniak, AM, Rallis, et al |
Future Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Potential
of blockchain technology for supply chain and purchasing |
Wurstbauer, P, Lang, et al |
Fabriksoftware |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wysocki, PJ, Kwinta, et al |
Nowotwory |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Fighting COVID-19 and helping economy reopen by using blockchain technology |
Xin, W |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Yan, L |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yang, Y, Chen, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Blood purification methods in complex treatment of patients with a new coronavirus
infection |
Yaroustovsky, MB, Shukevich, et al |
Russian Journal of Anesthesiology and Reanimatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Yingling, ME |
Journal of Human Rights and Social Work |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Younes, C |
Digestive and Liver Disease |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zaeh, SandraE, Page, et al |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zhang, Y, Han, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zingone, F, Buda, et al |
Digestive and Liver Disease |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
2020 International
Conference on Intelligent Systems and Computer Vision, ISCV 2020 |
|
2020 International Conference on Intelligent Systems and Computer Vision, ISCV 2020 |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chung-kuo Tsao Chih/China Pulp and Paper |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
European Journal of International Law |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
[Confined community health: Reflections and experiences from the local public health.] |
|
Rev Esp Salud Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Vet Rec |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Vet Rec |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
[Expert consensus on special blood purification technics in patients
with corona virus disease 2019] |
|
Zhonghua Nei Ke Za Zhi |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
16th International
Conference on Intelligent Computing, ICIC 2020 |
|
|
Commentary/Editorial| Commentaire/Éditorial |
|
Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, comorbidities.*
Long-term Sequelae: Data or Studies that describe the long-term effects of COVID-19 from lingering symptoms to severe conditions that persiste after acute infection has resolved.
Mental Health: All studies on mental health impacts or consequences of the pandemic for both general population and healthcare workers.
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
Articles in this category include: COVID-19 AND substance abuse, domestic violence, social media analysis, adherence to public health measures and knowledge, attitudes and beliefs studies related to the pandemic.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Séquelles à long terme:
Données ou études décrivant les effets à long terme du COVID-19, des symptômes persistants aux affections graves qui persistent après la résolution de l'infection aiguë.
Santé mentale:
Toutes les études sur les impacts ou les conséquences de la pandémie sur la santé mentale tant pour la population générale que pour les travailleurs de la santé.
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Les articles de cette catégorie comprennent: COVID-19 ET toxicomanie, violence domestique, analyse des médias sociaux, respect des mesures de santé publique et études sur les connaissances, les attitudes et les croyances liées
à la pandémie.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives