Good afternoon,

There are 343 citations in today’s scan. 190 were considered primary research or review literature.

Highlights today include:

CANADA

· Asgary et al developed an agent-based model and simulation tool to analyze the outcomes and effectiveness of different testing strategies and scenarios in schools with various number of classrooms and class sizes in Ontario. The findings show that testing can be an effective method in controlling the SARS-CoV-2 infection in schools if taken frequently, with expedited test results and self-isolation of infected students at home. Also, show that while testing cannot eliminate the risk and has its own challenges, it can significantly control outbreaks when combined with other measures, such as masks and other protective measures.

· Gross et al. studied WCB-Alberta's transition to remote rehabilitation service delivery to suppress the outbreak of COVID-19. Workers undergoing remote assessments were significantly more likely to work in health care or trades, did not require an interpreter, and were less likely to be working or judged as ready to return to work.  Number of completed rehabilitation programs also reduced from 125.6 to 40.8 per week, with most (67.1%) remote programs being functional restoration.

TRANSMISSION

· Murphy et al. describe an outbreak of 59 cases of COVID-19 in Ireland linked to air travel. The outbreak originated with 13 cases linked by a 7h, 17% occupancy flight into Ireland in summer 2020. The flight-associated attack rate was 9.8-17.8%. Asymptomatic/pre-symptomatic transmission in-flight from a point source is implicated by 99% homology across the virus genome in five cases travelling from three different continents.

EPIDEMIOLOGY

· Miyake et al aimed to explore the rate of SARS-CoV-2 positivity in saliva and gastric and intestinal fluids to which endoscopy medical staff are exposed. Asymptomatic patients, even those with no detectable virus in their saliva, had SARS-CoV-2 in their gastrointestinal tract. Endoscopy medical staff should be aware of infection when performing procedures.

CLINICAL DATA

· Torres et al report the case of a Brazilian doctor who, after presenting a mild clinical episode of COVID-19 with molecular confirmation by RT-PCR in March 2020, appeared with a new acute infection by SARS-CoV-2 three months later. There is a strong probability that these two episodes of infection were caused by different viral strains and that each genetic variation is related to specific clinical manifestations.

· Shuwa et al. describe the phenotypic and functional characteristics of B and T cells in healthy individuals and individuals with acute or convalescent COVID-19. The authors report the long-term alterations in B and T cell function of previously hospitalized COVID-19 patients and propose that alterations could impact long-term immunity and contribute to persistent symptoms observed in convalescent COVID-19 patients.

VACCINE RESEARCH

· Polak et al applied technology in natural extracellular vesicles (EVs) engineering, to express the S proteins of SARS-CoV-2 embedded in the EVs, which mimic the virus with its fully native spikes. They develop CoVEVax the “prototype of vaccines”, where the sole exchange of the envelope proteins on EVs leads to the generation of new vaccine candidates against emerging viruses.

· Turan et al optimized an inactivated virus vaccine. We showed that the vaccinated mice showed lowered SARS-CoV-2 viral copy number in oropharyngeal specimens along with humoral and cellular immune responses against the SARS-CoV-2, including the neutralizing antibodies similar to those shown in Balb/c mice without substantial toxicity.

IMMUNOLOGY – ANIMAL MODEL

· Kandeil et al. tested whether BCG, Pneumococcal, Rotavirus, Diphtheria, Tetanus, Pertussis, Hepatitis B, Haemophilus influenzae, Hepatitis B, Meningococcal, Measles, Mumps, and Rubella vaccines provide cross-reactive neutralizing antibodies against SARS-CoV-2 in BALB/c mice. Results indicated none of these vaccines provided antibodies capable of neutralizing SARS-CoV-2 up to seven weeks post-vaccination.

PUBLIC HEALTH RESPONSE

· Marcec et al collected public opinion survey results about attitudes towards SARS-CoV-2 vaccination in 26 European countries. On average only 58% (n=24,970) of responders across Europe were willing to get a SARS-CoV-2 vaccine once it becomes available, 16% were neutral, and 26% were not planning to vaccinate against SARS-CoV-2.

· Bokemper et al explored vaccine hesitancy through randomized survey. A potential driver of hesitancy in the United States is the politicization of a potential vaccine, including when one might be approved with respect to the presidential election and which public figures are endorsing its safety and efficacy. This survey showed that announcing approval of a COVID-19 vaccine one week before the election compared to one week after considerably reduces both beliefs about its safety and efficacy and willingness to receive it. However, endorsement by Dr. Fauci increased uptake and confidence in safety even if a vaccine receives pre-election approval.

Regards,

Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox

Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics, Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news

Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics / Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI, Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux

PUBLICATIONS	AUTHORS / AUTEURS	SOURCE	FOCI / DOMAINE	SUMMARY / SOMMAIRE
Identification of Covid-19 suspect cases through a digital triage: a multicenter Italian-Iranian study on	Abbadessa,  Gianmarco,  Sparaco, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	This study used digital triage monitoring to explore the frequency of demographic and clinical characteristics suggestive for COVID-19 among two large samples of people with Multiple Sclerosis (pwMS) and to evaluate the association between demographic and clinical characteristics of pwMS and the likelihood of being identified as COVID-19 suspect. A Google Forms triage was e-mailed to 3500 pwMS. pwMS suspects for having COVID-19 were: A) patients who reported recent contact with a patient with suspicion or diagnosis of COVID-19 and the presence of at least one symptom suggestive of COVID-19; B) pwMS with at least two symptoms suggestive of COVID-19. 1035/1500 questionnaires were fulfilled by Italian pwMS and 1346/2000 by Iranian patients. 4.9% of Iranian and 1,5% of Italian pwMS met our criteria for the COVID-19-suspect case. Only diabetes and heart disease (OR: 5,374, 95%CI: 2,470 – 11,985, p-value<0.001) were independently associated with the likelihood of being suspect for COVID-19.
An Epidemiological Study of Cut Throat Injury During COVID-19 Pandemic in a Tertiary Care Centre	Acharya,  S,  Dash, et al	Indian Journal of Otolaryngology and Head and Neck Surgery	Healthcare Response | Réponse des soins de santé	To find out incidence, prevalence, various modes and pattern of cutthroat injury during COVID-19 pandemic and compare with prior non pandemic period. It is a retrospective study of cutthroat patients who were managed in ENT Dept. VIMSAR, Burla, Sambalur, Odisha, India from 1st September 2019 to 31st August 2020. Total cases were divided into group-A (prior to COVID-19 pandemic) and group-B (during COVID-19 pandemic) and analysed. Total 24 cutthroat injury cases were treated over 1 year, which was 0.054% of total cases attended at casualty and 2.371% of total IPD patients treated. In GROUP-A, total 10 cases with M:F = 9:1,suicidal 4 cases (40%), homicidal 6 cases (60%), and no accidental cases were recorded. While in GROUP-B, total 14 case with M:F = 14:0, suicidal 9 cases (64.28%), homicidal 3 cases (21.42%) and accidental 2 (14.28%) cases were recorded. In our study majority of cases were male with M:F = 23:1. Common age group belongs to 20–30 years with LSES and farmer by occupation. Zone II injury had incidence of 70.83%. Homicide cases proportionally high during non-COVID period while suicide cases high during COVID-19 pandemic. Association of COVID-19 pandemic with suicidal cut throat injury is seems to be significant. Among predisposing risk factors for suicidal, depression during COVID-19 pandemic had seen in 53.84% of total suicidal cases.
Impact of the COVID-19 Pandemic on Surgical Residency Training: Perspective from a Low-Middle Income Country	Adesunkanmi,  AO,  Ubom, et al	World J Surg	Healthcare Response | Réponse des soins de santé	A cross-sectional survey of surgical residents in Nigeria was conducted between 27 July 2020 and 14 August 2020. A structured questionnaire designed using the free software Google Forms(®) was utilised for the study. The questionnaire was electronically distributed randomly to 250 surgical residents via emails and social media platforms including WhatsApp and Telegram. At the end of the study period, 207 surgical residents completed and submitted the questionnaire, giving a response rate of 82.8%. The majority of respondents reported a reduction (164, 79.2%) or cancellation (11, 5.3%) of postgraduate programmes in their institutions. Of those who had academic programmes, meetings were done using virtual technology in all instances. The majority of respondents reported seeing fewer patients in the outpatient clinics (173, 83.6%), as well as a reduction in the number of emergency and elective operations (58.5% and 90.8%, respectively). About a third of the respondents (70, 33.8%) were contemplating emigrating from the country.
Emergency department crowding and hospital transformation during COVID-19, a retrospective, descriptive study of a university hospital in Stockholm, Sweden	Af Ugglas,  B,  Skyttberg, et al	Scand J Trauma Resusc Emerg Med	Healthcare Response | Réponse des soins de santé	The aim of this study is to describe the Karolinska university Hospital (KH; Stockholm, Sweden) response to the COVID-19 crisis, and how ED crowding, and important input, throughput and output factors for ED crowding developed at KH during a 30-day baseline period followed by the first 60 days of the COVID-19 outbreak in Stockholm Region. As new working methods were introduced between phase 2 and 3, ED length of stay (LOS) declined from mean (95% CI) 386 (373-399) minutes to 307 (297-317). Imaging proportion was reduced from 29 to 18% and admission rate increased from 34 to 43%. Correlation (95% CI) between emergency ward occupancy and ED LOS by phase was 0.94 (0.55-0.99).
Within-Host Diversity of SARS-CoV-2 in COVID-19 Patients With Variable Disease Severities	Al Khatib,  HA,  Benslimane, et al	Frontiers in Cellular and Infection Microbiology	Clinical data| Données cliniques Coronavirology| Coronavirologie	Here, we investigated the within-host virus diversity in COVID-19 patients with different clinical manifestations. We compared SARS-COV-2 genetic diversity in 19 mild and 27 severe cases. Viral RNA was extracted from nasopharyngeal samples and sequenced using the Illumina MiSeq platform. This was followed by deep-sequencing analyses of SARS-CoV-2 genomes at both consensus and sub-consensus sequence levels. Consensus sequences of all viruses were very similar, showing more than 99.8% sequence identity regardless of the disease severity. However, the sub-consensus analysis revealed significant differences in within-host diversity between mild and severe cases. Patients with severe symptoms exhibited a significantly (p-value 0.001) higher number of variants in coding and non-coding regions compared to mild cases. Analysis also revealed higher prevalence of some variants among severe cases. Most importantly, severe cases exhibited significantly higher within-host diversity (mean = 13) compared to mild cases (mean = 6). Further, higher within-host diversity was observed in patients above the age of 60 compared to the younger age group. These observations provided evidence that within-host diversity might play a role in the development of severe disease outcomes in COVID-19 patients; however, further investigations are required to elucidate this association.
The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase	Alhammad,  YousefMO,  Kashipathy, et al	bioRxiv	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	SARS-CoV-2 and other SARS-like-CoVs encode 3 tandem macrodomains within non-structural protein 3 (nsp3). The first macrodomain, Mac1, is conserved throughout CoVs, and binds to and hydrolyzes mono-ADP-ribose (MAR) from target proteins. Mac1 is essential for pathogenesis in multiple animal models of CoV infection. Here we report the crystal structure of SARS-CoV-2 Mac1 in complex with ADP-ribose. SARS-CoV-2, SARS-CoV and MERS-CoV Mac1 exhibit similar structural folds and all 3 proteins bound to ADP-ribose with low μM affinities. Importantly, using ADP-ribose detecting binding reagents in both a gel-based assay and novel ELISA assays, we demonstrated de-MARylating activity for all 3 CoV Mac1 proteins, with the SARS-CoV-2 Mac1 protein leading to a more rapid loss of substrate compared to the others. In addition, none of these enzymes could hydrolyze poly-ADP-ribose. We conclude that the SARS-CoV-2 and other CoV Mac1 proteins are MAR-hydrolases with similar functions, indicating that compounds targeting CoV Mac1 proteins may have broad anti-CoV activity.
The Psychological Impact of COVID-19 Pandemic and Lockdown on Caregivers of People with Dementia	Altieri,  Manuela,  Santangelo, et al	SSRN- Lancet prepublication	Public Health response| Interventions de santé publique	We performed a study to measure the change of psychological symptoms during quarantine/self-isolation for COVID-19 in a sample of Italian caregivers of people with dementia (pwD). Eighty-four caregivers of pwD completed an online survey including questionnaires assessing depressive symptomatology and anxiety before and during the lockdown, caregiver burden and levels of resilience. The MANOVA revealed an effect of time (before and during the lockdown) in the whole group on depression scores; a significant interaction between time and resilience was found on anxiety scores, revealing that caregivers with high resilience showed a more significant increase of anxiety levels during lockdown than caregivers with low resilience. Moreover, the regression analysis revealed that caregiver burden was associated negatively with resilience scores, and positively with higher functional dependence.
The Impact of the COVID-19 Pandemic on Invasive Pneumococcal Disease and the Risk of Pneumococcal Coinfection with SARS-CoV-2: Prospective National Cohort Surveillance, England	Amin-Chowdhury,  Zahin	SSRN- Lancet prepublication	Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	Public Health England conducts invasive pneumococcal disease (IPD) and COVID-19 surveillance in England. IPD trends from 2000/01 to 2019/20 were analysed and cases between 01 February and 30 June 2020 were linked with laboratory-confirmed SARS-CoV-2 infections. IPD incidence in 2019/20 (7.6/100,000; 3,964 cases) was 30% (IRR 0.70, 95%CI, 0.18-2.67) lower compared to 2018/19 (10.9/100,000, 3,964 cases) with large reductions observed across all age-groups during March-June 2020. The serotypes responsible for IPD during 2019/20 were similar to previous years. There were 160,886 SARS-CoV-2 infections and 1,159 IPD cases between February and June 2020, including 40 IPD/SARS-CoV-2 coinfections (0.025% 95%CI, 0.018-0.034] of SARS-CoV-2 infections; 3.5% 95%CI, 2.5-4.8] of IPD cases), 21 with COVID-19 diagnosed 3-28 days after IPD and 27 who developed COVID-19 >28 days after IPD. Case fatality was 63.2% (25/40) in the coinfection group compared to 47.6% (10/21) in those who developed COVID-19 3-14 days after IPD, and 33.3% (9/27) in patients who developed IPD and COVID-19 more than 28 days apart (p<0.001).
Is crowdsourcing a reliable method for mass data acquisition? The case of COVID-19 spread in greece during spring 2020	Antoniou,  V,  Vassilakis, et al	ISPRS International Journal of Geo-Information	Public Health response| Interventions de santé publique	This study  presents a GIS-based crowdsourcing application that was launched soon after the first COVID-19 cases had been recorded in Greece, motivated by the need for fast, location-wise data acquisition regarding COVID-19 disease spread during spring 2020, due to limited testing. A single question was posted through a web App, to which the anonymous participants subjectively answered whether or not they had experienced any COVID-19 disease symptoms. It was found that the application was rapidly disseminated to the entire Greek territory via social media, having, thus, a great public reception. The higher percentages of participants experiencing symptoms coincided geographically with the highly populated urban areas, having also increased numbers of confirmed cases, while temporal variations were detected that accorded with the restrictions of activities.
Ozone as Adjuvant Support in the Treatment of COVID-19: A Preliminary Report of Probiozovid Trial	Araimo,  F,  Imperiale, et al	J Med Virol	Clinical data| Données cliniques Therapeutics| Thérapeutique	This study evaluated the adjuvant use of systemic oxygen-ozone administration in the early control of disease progression in patients with COVID-19 pneumonia. No differences in the characteristics between groups were observed at baseline. As a preliminary report it was observed that one patient for each group needed intubation and was transferred to ITU. No deaths were observed at 7-14 days of follow up. Thirty-day mortality was 8,3% for ozone group and 10% for controls. Ozone therapy didn't significantly influence inflammation markers, haematology profile and lymphocyte subpopulations of patients treated.
Clinical Characteristic of Pregnant Women with COVID-19: A Nationwide Questionnaire Survey in Japan	Arakaki,  Tatsuya,  Hasegawa, et al	SSRN- Lancet prepublication	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study describes the clinical characteristics and outcomes of pregnant women with COVID-19 in Japan. Seventy-two pregnant women were reported to be diagnosed with COVID-19 between January and June 2020. The positive rate of the universal screening test for SARS-CoV-2 for asymptomatic pregnant women was 0·03% (2/7428). The most common route of infection was familial (57%). Fifty-eight pregnant women with COVID-19 were symptomatic, of which 5 (8·6%) had a severe infection. There was one death, a tourist. Severe respiratory symptoms, oxygen administration, and pneumonia were frequently reported in the 3rd trimester and postpartum period compared to early pregnancy (22·2% vs. 2·5% (p=0·03), 38·9% vs. 7·5% (p=0·01), and 50·0% vs. 7·5% (p<0·01), respectively). All pregnant women with COVID-19 delivered by cesarean section, regardless of symptoms. There was no SARS-Cov-2 transmission to the newborns.
COVID-19 in Spain and India: Comparing Policy Implications by Analyzing Epidemiological and Social Media Data	Asawa,  Parth,  Gaur, et al	arXiv	Epidemiology| Épidémiologie Public Health response| Interventions de santé publique	This study proposed data-driven investigation into effective public health policies to allow public health experts in other nations to decide future courses of action to control the outbreaks of disease and epidemics.  Chose Spain and India to present the analysis on regions that were similar in terms of certain factors: (1) population density, (2) unemployment rate, (3) tourism, and (4) quality of living. The authors assumed that citizen ideology obtainable from twitter conversations can provide insights into conformity to policy and suitably reflect on future case predictions. A milestone when the curves show the number of new cases diverging from each other is used to define a time period to extract policy-related tweets while the concepts from a causality network of policy-dependent sub-events are used to generate concept clouds. The number of new cases is predicted using sentiment scores in a regression model. Found that the new case predictions reflects twitter sentiment, meaningfully tied to a trigger sub-event that enables policy-related findings for Spain and India to be effectively compared.
Simulating Preventative Testing of SARS-CoV-2 in Schools: Policy Implications	Asgary,  Ali,  Gabriela Cojocaru, et al	SSRN- Lancet prepublication	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	This study developed an agent-based model and simulation tool that can be used to analyze the outcomes and effectiveness of different testing strategies and scenarios in schools with various number of classrooms and class sizes in Ontario. Applied a modified version of a standard SEIR disease transmission model that includes symptomatic and asymptomatic infectious populations, and that incorporates feasible public health measures. The findings show that testing can be an effective method in controlling the SARS-CoV-2 infection in schools if taken frequently, with expedited test results and self-isolation of infected students at home. Findings show that while testing cannot eliminate the risk and has its own challenges, it can significantly control outbreaks when combined with other measures, such as masks and other protective measures.
Characterizing Human Mobility Patterns During COVID-19 using Cellular Network Data	Ayan,  NecatiA,  Damasceno, et al	arXiv	Public Health response| Interventions de santé publique	This paper analyzed and compared cellular network usage data from pre-lockdown, during lockdown, and post-lockdown phases surrounding the COVID-19 pandemic to understand and model human mobility patterns during the pandemic, and evaluate the effect of lockdowns on mobility. Analysis reveals that the total number of cellular connections decreases to 78% during the lockdown phase and then increases to 85% of the pre-COVID era as the lockdown eases. Observed that as more people work remotely, there is a shift in the antennas incurring top 10% of the total traffic, with the number of connections made to antennas in downtown Rio reducing drastically and antennas at other locations taking their place. Also, observed that while nearly 40-45% users connected to only 1 antenna each day during the lockdown phase indicating no mobility, there are around 4% users (i.e., 80K users) who connected to more than 10 antennas, indicating very high mobility.
[COVID-19, neoliberalism and health systems in 30 european countries: relationship to deceases.]	Barrera-Algarín,  E,  Estepa-Maestre, et al	Rev Esp Salud Publica	Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	This study analyzed the relationship between the number of deaths from COVID-19 in the global pandemic declared since December 2019 and health policies and investment in European countries.  Five countries were found, which gave values above 300 deaths per million (data from April 27, 2020): United Kingdom; (305.39), France (350.16), Italy (440.67), Spain (495.99) and Belgium (612.1). Precisely, in the countries that recorded the most deaths (United Kingdom, France, Italy, Spain and Belgium) on April 27, did not find high values of TEST performance. The analysis found that the lower the investment of public spending in health (per capita), the higher the number of deaths per COVID-19 per million inhabitants, the lower the coverage of hospital beds, and the lower the number of doctors. Also, found that the lower the expenditure on public health, the higher the GINI coefficient (thus greater social inequality).
Interaction Energies of the Human ACE2 Molecular Recognition by SARS-CoV-2	Batista Júnior,  João	SSRN- Lancet prepublication	Coronavirology| Coronavirologie	This study presents a comprehensive and quantitative analysis of interaction energies of the human ACE2 molecular recognition by CoVs that may contribute to further understand the higher infectivity and transmissibility of SARS-CoV-2 compared to SARS-CoV and HCoV-NL63, furthermore, this could help explain why SARS-CoV-2 has an enhanced ability for pathogenicity.
Country-level pandemic risk and preparedness classification based on COVID-19 data: A machine learning approach	Bird,  JJ,  Barnes, et al	PLoS One	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	This study presents a three-stage Machine Learning strategy to country-level risk classification based on countries that are reporting COVID-19 information.  A K% binning discretisation (K = 25) is used to create four risk groups of countries based on the risk of transmission (coronavirus cases per million population), risk of mortality (coronavirus deaths per million population), and risk of inability to test (coronavirus tests per million population). The four risk groups produced by K% binning are labelled as 'low', 'medium-low', 'medium-high', and 'high'. Coronavirus-related data are then removed and the attributes for prediction of the three types of risk are given as the geopolitical and demographic data describing each country. Thus, the calculation of class label is based on coronavirus data but the input attributes are country-level information regardless of coronavirus data.
Persuasive Messaging to Encourage COVID-19 Risk Reduction	Bokemper,  Scott,  Huber, et al	Research Square prepub	Public Health response| Interventions de santé publique	This study examined the types of public health messages that are effective at changing people’s beliefs and intentions to practice social distancing to slow the spread of COVID-19. Using both a convenience sample and a nationally representative sample of Americans, found that a message that reframes bravery as recklessness and a message that highlights the need for everyone to take action to protect others are the most effective at increasing beliefs and intentions related to social distancing.
Timing of COVID-19 Vaccine Approval and Endorsement by Public Figures	Bokemper,  ScottE,  Huber, et al	Research Square prepub	Public Health response| Interventions de santé publique	This study explored vaccine hesitancy through randomized survey. A potential driver of hesitancy in the United States is the politicization of a potential vaccine, including when one might be approved with respect to the presidential election and which public figures are endorsing its safety and efficacy. This survey showed that announcing approval of a COVID-19 vaccine one week before the election compared to one week after considerably reduces both beliefs about its safety and efficacy and willingness to receive it. However, endorsement by Dr. Fauci increased uptake and confidence in safety even if a vaccine receives pre-election approval.
A genome-wide CRISPR/Cas9 knock-out screen identifies the DEAD box RNA helicase DDX42 as a broad antiviral inhibitor	Bonaventure,  Boris,  Rebendenne, et al	bioRxiv	Clinical data| Données cliniques Immunology | Immunologie	With the aim of identifying new cellular inhibitors of HIV-1, this study developed a strategy to see the ability of type 1 interferon (IFN) to potently inhibit HIV-1 infection, in order to create a cellular environment hostile to viral replication. This approach led to the identification of the DEAD-box RNA helicase DDX42 as an intrinsic inhibitor of HIV-1. Depletion of endogenous DDX42 using siRNA or CRISPR/Cas9 knock-out increased HIV-1 infection, both in model cell lines and in physiological targets of HIV-1, primary CD4+ T cells and monocyte-derived macrophages (MDMs), and irrespectively of the IFN treatment. Similarly, the overexpression of a dominant-negative mutant of DDX42 positively impacted HIV-1 infection, whereas wild-type DDX42 overexpression potently inhibited HIV-1 infection. The positive impact of endogenous DDX42 depletion on HIV-1 infection was directly correlated to an increase in viral DNA accumulation. Also revealed that DDX42 potently inhibits other pathogenic viruses, including Chikungunya virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Long-term persistence of neutralizing memory B cells in SARS-CoV-2	Bull,  Rowena,  Abayasingam, et al	Research Square prepub	Clinical data| Données cliniques Immunology | Immunologie	Here we monitored antibody responses against SARS-CoV-2 receptor binding domain (RBD) for up to six months after infection. While antibody titres were maintained, half of the cohort’s neutralising responses had returned to background. However, encouragingly in a selected subset of 13 participants, 12 had detectable RBD-specific memory B cells and these generally increased out to 6 months. Furthermore, we were able to generate monoclonal antibodies with SARS-CoV-2 neutralising capacity from these memory B cells. Overall our study suggests that the loss of neutralising antibodies in plasma may be countered by the maintenance of neutralising capacity in the memory B cell repertoire.
Inpatient Diabetes Care during the COVID-19 Pandemic: A Diabetes UK rapid review of health care professionals' experiences using semi-structured interviews	Burr,  O,  Berry, et al	Diabet Med	Healthcare Response | Réponse des soins de santé	he COVID-19 pandemic has impacted the way care is delivered across the UK. We interviewed 28 health care professionals and hospital teams from across the UK to find out about their experiences of delivering inpatient diabetes care during the first peak of the COVID-19 pandemic. We found that disruption to inpatient diabetes services created positive environments and opportunities for new ways of working, but in the minority, impacted on the quality of care clinicians felt they were able to deliver.
SARS-CoV-2 infection in a patient with propionic acidemia	Caciotti,  A,  Procopio, et al	Orphanet J Rare Dis	Clinical data| Données cliniques	We describe a 14-month-old boy, with a previous diagnosis of propionic acidemia (PA) by expanded newborn screening, who, admitted for a suspected metabolic crisis, tested positive for SARS-CoV-2.
The 120-Day COVID-19 Epidemic in the Metropolitan Area of Turin, Italy	Candela,  Filippo,  Mulassano, et al	SSRN- Lancet prepublication	Public Health response| Interventions de santé publique	This research aimed at study the impact of covid-19 epidemic on several aspects of the metropolitan area of Turin, a large city located in the north-west of Italy. The rise of covid-19 epidemic and the subsequent lockdown was significant associated with all the variables considered excluding the grants requested to a philanthropic foundation. While the epidemic was growing, there were a significant change in the trend of stock values of two important companies of the area. Citizens increased their use of internet and there was a growing interest in the pandemic identified by Google research. Electricity consumption, traffic and particulate matter decreased.
Knowledge, Attitudes and Practices Towards COVID-19: A Cross-Sectional Study in the Resident Cape-Verdean Population	Carvalho-Alves,  Maria	SSRN- Lancet prepublication	Public Health response| Interventions de santé publique	The present study aimed at assessing the knowledge, attitudes and practices of the Cape Verdean resident population towards COVID-19. The overall correct answer rate related to the knowledge about COVID-19 was 82% (9.0251 / 11 * 100), 1970 (98.70%) of the participants declared they had stayed at home in recent days, 1926 (96.49%) had not attended parties, funerals or crowded places and 1860 (93.19%) confirmed changes in daily routines due to COVID-19. The majority 1797 (90.26%) of the participants prefered receiving information about COVID-19 in Portuguese and trusted information transmitted by health professionals. Furthermore, television, radio and newspapers were the preferred means of transmitting information about COVID-19. The level of knowledge of the participants does not fully explain the prevention and control practices and attitudes towards COVID-19 (R2 = 0.012; EP = 0.860; F (1.1995) = 24083; P-value = 0.000).
Z-uncertain probabilistic linguistic variables and its application in emergency decision making for treatment of COVID-19 patients	Chai,  J,  Xian, et al	International Journal of Intelligent Systems	Healthcare Response | Réponse des soins de santé	In this paper, we first consider the credibility of the information and propose the concept of Z-uncertain probabilistic linguistic variables (Z-UPLVs). Subsequently, the operational rules, normalization, distance and similarity measures, and comparison method of Z-UPLVs are introduced. Then, a probability calculation method based on credibility, an extended TOPSIS method, and some operators are proposed, which can be applied to emergency decision making in the Z-uncertain probabilistic linguistic (Z-UPL) environment. Finally, an emergency decision-making case of COVID-19 patients and comparative analysis illustrate the necessity and effectiveness of this method.
33061826; Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients	Chen,  D,  Sun, et al	Mediators of inflammation	Clinical data| Données cliniques	This study aimed at determining the relationship between baseline cystatin C levels and COVID-19 and investigating the potential prognostic value of serum cystatin C in adult patients with COVID-19. The highest cystatin C level was significantly related to more severe inflammatory conditions, worse organ dysfunction, and worse outcomes among patients with COVID-19 (P values < 0.05). In the adjusted logistic regression analyses, the highest cystatin C level and ln-transformed cystatin C levels were independently associated with the risks of developing critically ill COVID-19 and all-cause death either in overall patients or in patients without chronic kidney disease (P values < 0.05). As a potential inflammatory marker, increasing baseline levels of serum cystatin C might independently predict adverse outcomes for COVID-19 patients. Serum cystatin C could be routinely monitored during hospitalization, which showed clinical importance in prognosticating for adult patients with COVID-19.
SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway	Chen,  Da-Yuan,  Khan, et al	bioRxiv	Coronavirology| Coronavirologie	Here, we performed global proteomic analysis of the virus-host interface in a newly established panel of phenotypically diverse, SARS-CoV-2-infectable human cell lines representing different body organs. This revealed universal inhibition of interferon signaling across cell types following SARS-CoV-2 infection. We performed systematic analyses of the JAK-STAT pathway in a broad range of cellular systems, including immortalized cell lines and primary-like cardiomyocytes, and found that several pathway components were targeted by SARS-CoV-2 leading to cellular desensitization to interferon. These findings indicate that the suppression of interferon signaling is a mechanism widely used by SARS-CoV-2 in diverse tissues to evade antiviral innate immunity, and that targeting the viral mediators of immune evasion may help block virus replication in patients with COVID-19.
SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19	Chen,  P,  Nirula, et al	N Engl J Med	Clinical data| Données cliniques Therapeutics| Thérapeutique	In this ongoing phase 2 trial involving outpatients with recently diagnosed mild or moderate Covid-19, we randomly assigned 452 patients to receive a single intravenous infusion of neutralizing antibody LY-CoV555 in one of three doses (700 mg, 2800 mg, or 7000 mg) or placebo and evaluated the quantitative virologic end points and clinical outcomes. In this interim analysis of a phase 2 trial, one of three doses of neutralizing antibody LY-CoV555 appeared to accelerate the natural decline in viral load over time, whereas the other doses had not by day 11.
Laboratory markers associated with COVID-19 progression in patients with or without comorbidity: A retrospective study	Chen,  Z,  Zhang, et al	J Clin Lab Anal	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study aimed to investigate laboratory markers for COVID-19 progression in patients with different medical conditions. We performed a multicenter retrospective study of 836 cases in Hubei. Lactate dehydrogenase was a reliable predictor associated with COVID-19 severity and mortality in patients with different medical conditions. Laboratory biomarkers for mortality risk were not identical in patients with comorbidities, suggesting multiple pathophysiological mechanisms following COVID-19 infection.
How Emergency Care Congestion Increases Covid-19 Mortality: Evidence from Lombardy, Italy	Ciminelli,  Gabriele,  Garcia-Mandico, et al	medRxiv	Epidemiology| Épidémiologie	This paper quantifies how much system congestion may have increased mortality rates, using distance to the ICU as a proxy for access to emergency care. We match daily death registry data for almost 1,500 municipalities in Lombardy, Italy, to data on geographical location of all ICU beds in the region. We find that Covid-19 mortality is up to 60% higher in the average municipality -- which is 15 minutes driving away from the closest ICU -- than in a municipality with an ICU in town. This difference is larger in areas and in days characterized by an abnormal number of calls to the emergency line.
Use PROSEVA study criteria not COVID-19 phenotype to guide proning treatment decisions	Craven,  TH,  Young, et al	Journal of the Intensive Care Society	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	We analysed the cohort of 47 patients invasively ventilated with COVID-19 pneumonia admitted to two general intensive care units in the city of Edinburgh, UK between 11 March and 19 April 2020. The positive relationship between pre-proning dynamic lung compliance and change in PF ratio implies those with higher compliance will have a better improvement in oxygenation after proning. We cautiously conclude that the proposed separation into sub-phenotypes based on respiratory system compliance is not supported, especially with regard to effect on clinical practice.
Sub-national longitudinal and geospatial analysis of COVID-19 tweets	Cuomo,  RE,  Purushothaman, et al	PLoS One	Public Health response| Interventions de santé publique	METHODS: In an effort to better understand the impacts of COVID-19, we concurrently assessed the geospatial and longitudinal distributions of Twitter messages about COVID-19 which were posted between March 3rd and April 13th and compared these results with the number of confirmed cases reported for sub-national levels of the United States. Geospatial hot spot analysis was also conducted to detect geographic areas that might be at elevated risk of spread based on both volume of tweets and number of reported cases. RESULTS: Statistically significant aberrations of high numbers of tweets were detected in approximately one-third of US states, most of which had relatively high proportions of rural inhabitants. Geospatial trends toward becoming hotspots for tweets related to COVID-19 were observed for specific rural states in the United States.
SARS-CoV-2 evades immune detection in alveolar macrophages	Dalskov,  L,  Møhlenberg, et al	EMBO Rep	Clinical data| Données cliniques Coronavirology| Coronavirologie	n this study, AMs from non-infectious donors are challenged with SARS-CoV-2. We demonstrate that challenged AMs are incapable of sensing SARS-CoV-2 and of producing an IFN response in contrast to other respiratory viruses, like influenza A virus and Sendai virus, which trigger a robust IFN response. The absence of IFN production in AMs upon challenge with SARS-CoV-2 could explain the initial asymptotic phase observed during COVID-19 and argues against AMs being the sources of pro-inflammatory cytokines later during infection.
Computed Tomography-based determinants for predicting death and ICU requirement in patients suffering COVID-19	Dehgan,  Marzie,  Khalesi, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques	The present study aimed to determine main lung CT-related correlates of disease severity (Intensive Care Units (ICU) requiring) as well as death in COVID -19 patients. Methods: This cross-sectional study was performed on 515 consecutive patients with definitive diagnosis of COVID-19 admitted to one of the COVID -19 referral hospitals in Tehran. Results: The mean follow-up of patients from the time of admission was 10.85±6.11 days.  During this period, a total of 29.1% were admitted to the ICU. Also, the mortality rate of patients was equal to 28.2%. According to multivariable logistic regression model with the presence of death-related correlates, crazy paving pattern, diffuse distribution of lesions, CT Severity Score (CTSS) score >12, the presence of plural effusion or emphysema were the main determinants of COVID -19 related death and should be considered for presenting new scoring system for predicting death following COVID -19 disease. In similar model, CTSS score >12 along with the presence of plural effusion, emphysema, or pulmonary hypertension were the main determinants of requiring ICU admission.
33054129; No evidence of hemoglobin damage by SARS-CoV-2 infection	DeMartino,  AW,  Rose, et al	Haematologica	Epidemiology| Épidémiologie Clinical data| Données cliniques	We compared clinical data from 21 critically ill COVID-19 patients to 21 non-COVID-19 ARDS patient controls, generating hemoglobin-oxygen dissociation curves from venous blood gases. This curve generated from the COVID-19 cohort matched the idealized oxygen-hemoglobin dissociation curve well. We further analyzed hemoglobin, total bilirubin, lactate dehydrogenase, iron, ferritin, and haptoglobin levels. For all analyzed parameters, patients with COVID-19 had similar levels compared to patients with ARDS without COVID-19. These results indicate that patients with COVID-19 do not exhibit any hemolytic anemia or a shift in the normal hemoglobin-oxygen dissociation curve. We therefore conclude that COVID-19 does not impact oxygen delivery through a mechanism involving red cell hemolysis and subsequent removal of iron from the heme prosthetic group in hemoglobin.
Initial impact of COVID-19's stay-at-home order on motor vehicle traffic and crash patterns in Connecticut: an interrupted time series analysis	Doucette,  ML,  Tucker, et al	Inj Prev	Public Health response| Interventions de santé publique	This study sought to examine the impact of COVID-19's stay-at-home order on daily vehicle miles travelled (VMT) and MVCs in Connecticut. METHODS: Using an interrupted time series design, we analysed daily VMT and MVCs stratified by crash severity and number of vehicles involved from 1 January to 30 April 2017, 2018, 2019 and 2020. MVC data were collected from the Connecticut Crash Data Repository; daily VMT estimates were obtained from StreetLight Insight's database. RESULTS: The mean daily VMT significantly decreased 43% in the post stay-at-home period in 2020. While the mean daily counts of crashes decreased in 2020 after the stay-at-home order was enacted, several types of crash rates increased after accounting for the VMT reductions. Single vehicle crash rates significantly increased 2.29 times, and specifically single vehicle fatal crash rates significantly increased 4.10 times when comparing the pre-stay-at-home and post-stay-at-home periods.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies at Delivery in Women, Partners, and Newborns	Egerup,  P,  Fich Olsen, et al	Obstet Gynecol	Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie	OBJECTIVE: To investigate the frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in parturient women, their partners, and their newborns and the association of such antibodies with obstetric and neonatal outcomes. METHODS: From April 4 to July 3, 2020, in a single university hospital in Denmark, all parturient women and their partners were invited to participate in the study, along with their newborns. Participating women and partners had a pharyngeal swab and a blood sample taken at admission; immediately after delivery, a blood sample was drawn from the umbilical cord. The swabs were analyzed for SARS-CoV-2 RNA by polymerase chain reaction, and the blood samples were analyzed for SARS-CoV-2 antibodies. Full medical history and obstetric and neonatal information were available. RESULTS:  The adjusted serologic prevalence was 2.6% in women and 3.5% in partners. Seventeen newborns had SARS-CoV-2 immunoglobulin G (IgG) antibodies, and none had immunoglobulin M antibodies. No associations between SARS-CoV-2 antibodies and obstetric or neonatal complications were found. Full serologic data from 1,051 families showed an absolute risk of maternal infection of 39% if the partner had antibodies.
33070482; Characteristics and Outcomes of Patients Infected with SARS-CoV-2 in Israel: Correlation between Laboratory Findings on Admission to Emergency Department and Subsequent Respiratory Failure	Elhadad,  D,  Bronstein, et al	The Israel Medical Association journal : IMAJ	Epidemiology| Épidémiologie Clinical data| Données cliniques	OBJECTIVES: To describe the characteristics, outcomes, and potential associations of hospitalized COVID-19 patients in Israel. METHODS: We conducted a single-center, retrospective study of 58 consecutive laboratory-confirmed COVID-19 patients admitted to Laniado Hospital, Israel, between 14 March 2020 and 14 May 2020. Demographic, clinical, and laboratory data on admission were collected and analyzed, and the association to subsequent respiratory failure was assessed. RESULTS: Mean age of patients was 70.7 ± 16.9 years; 74% had at least one co-morbidity.  During hospitalization 15 patients Sephardi descent developed respiratory failure rates of 60% occurring on average 10.6 days following intubation. Laboratory tests at admission displayed a significant increase in C-reactive protein (CRP) and creatine kinase (CK) and a decrease in absolute lymphocyte count (ALC) in patients who eventually developed respiratory failure. Multivariate logistic analysis revealed an integrated parameter of CRP, CK, and ALC highly correlated with respiratory failure.
Safety and Efficacy of Imatinib for Hospitalized Adults with COVID-19: A structured summary of a study protocol for a randomised controlled trial	Emadi,  A,  Chua, et al	Trials	RCT	RCT protocol to evaluate the efficacy and safety of oral administration of imatinib combined with the Best Conventional Care (BCC) versus placebo plus BCC in hospitalized patients with COVID-19. DESIGN: This is an individual patient-level randomized, double-blind, placebo-controlled, two-parallel arm phase 3 study to evaluate the safety and efficacy of imatinib for the treatment of hospitalized adults with COVID-19. Participants will be followed for up to 60 days from the start of study drug administration.
Utility of Apical Lung Assessment on Computed Tomography Angiography as a COVID-19 Screen in Acute Stroke	Esenwa,  C,  Lee, et al	Stroke	Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	PURPOSE: Evaluation of the lung apices using computed tomography angiography of the head and neck during acute ischemic stroke (AIS) can provide the first objective opportunity to screen for coronavirus disease 2019 (COVID-19). METHODS: We performed an analysis assessing the utility of apical lung exam on computed tomography angiography for COVID-19-specific lung findings in 57 patients presenting with AIS. We measured the diagnostic accuracy of apical lung assessment alone and in combination with patient-reported symptoms and incorporate both to propose a COVID-19 era AIS algorithm. RESULTS: Apical lung assessment when used in isolation, yielded a sensitivity of 0.67, specificity of 0.93, positive predictive value of 0.19, negative predictive value of 0.99, and accuracy of 0.92 for the diagnosis of COVID-19, in patients presenting to the hospital for AIS.
Induced pulmonary comorbidities render CD-1 mice sensitive to SARS-CoV-2	Falach,  Reut,  Bar-On, et al	bioRxiv	Clinical data| Données cliniques Animal model | Modèle animal	Here we report that mild pulmonary injury induced by administration of acute-lung-injury stimulants, renders outbred CD-1 mice to be sensitive to SARS-CoV-2. Following intranasal pretreatment of mice with low doses of ricin or bleomycin, SARS-CoV-2 infection caused a severe disease manifested by sustained body loss and mortality rates of >50%. Low-dose-ricin pretreated mice displayed markedly higher levels of viral RNA than mice not pretreated with ricin, not only in the nasal turbinate, trachea and lungs but also in the serum and heart. The deleterious effects of SARS-CoV-2 infection in ricin-pretreated mice were effectively alleviated by passive transfer of polyclonal and monoclonal antibodies generated against SARS-CoV-2 or SARS-CoV-2 RBD.
In silico Investigation of Saponins and Tannins as Potential Inhibitors of SARS-CoV-2 main Protease (Mpro)	Falade,  Victoria Adeola,  Adelusi, et al	Research Square prepub	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Isolated saponins and tannins were evaluated for antiviral activity against SARS-CoV-2 Mpro via Molecular Docking and it was observed that a handsome number of the phytochemicals had binding affinity much better than Remdesivir, Dexamethasone, and N3 inhibitor which were used as the standard in this study. Further Investigation of drug-likeness, ADMET profile, and bioactivity of these phytochemicals revealed that binding affinity alone is not enough in the drug discovery process and that 4 hit compounds were identified as potential inhibitors of SARS-CoV-2Mpro. This preliminary study furnishes Ellagic acid, Arjunic acid, Theasapogenol B, and Euscaphic acid as potential inhibitors of SARS-CoV-2 Mpro with better pharmacokinetics and bioavailability compared to Remdesivir which is currently used compassionately.
Isolated maculopapular eruption localized to head and neck: A cutaneous sign of COVID-19 infection	Farabi,  B,  Atak, et al	Dermatol Ther	Clinical data| Données cliniques	Case report of a 55 year old female with COVID-19  who developed an asymptomatic, nonspecific rash on the chin and vesicular rashes in the upper lip.
Prognostic Factors for 30-Day Mortality in Critically Ill Patients With Coronavirus Disease 2019: An Observational Cohort Study	Ferrando-Vivas,  P,  Doidge, et al	Crit Care Med	Epidemiology| Épidémiologie Clinical data| Données cliniques	The objective of this study was to identify characteristics that predict 30-day mortality among patients critically ill with coronavirus disease 2019 in England, Wales, and Northern Ireland. Authors identified patient characteristics that predict an increased likelihood of death within 30 days of the start of critical care for patients with coronavirus disease 2019.
Bilateral Central Retinal Vein Occlusion in a 40-Year-Old Man with Severe Coronavirus Disease 2019 (COVID-19) Pneumonia	Gaba,  WH,  Ahmed, et al	Am J Case Rep	Clinical data| Données cliniques	Authors present the case of a 40-year-old man who presented with a 3-day history of shortness of breath, cough, and fever.  Early full-dose anticoagulation should be considered in high-risk patients with severe COVID-19 infection.
A comparison between manual and artificial intelligence-based automatic positioning in CT imaging for COVID-19 patients	Gang,  Yadong,  Chen, et al	Research Square prepub	Clinical data| Données cliniques	The objective of this study was to analyze and compare the imaging workflow, radiation dose and image quality for COVID-19 patients examined using either the conventional manual positioning (MP) method or an AI-based automatic positioning (AP) method. The AI-based automatic positioning and centering in CT imaging is a promising new technique for reducing radiation dose, optimizing imaging workflow and image quality in imaging the chest.
Acute hemolytic reaction in patients with novel coronavirus pneumonia induced by high-dose ribavirin injection: report of 2 cases	Gao,  J,  Qiao, et al	Adverse Drug Reactions Journal	Clinical data| Données cliniques	Authors discuss two female patients who received IV infusion of ribavirin injection, oral 2 lopinavir and ritonavir tablets twice daily, and aerosol inhalation of recombinant human interferon α2b for injection for novel coronavirus pneumonia. On the basis of continued use of the other 2 drugs, both of them were treated with ursodeoxycholic acid. The Hb and bilirubin level of the 2 patients gradually returned to normal.
Public acceptance of Covid-19 lockdown scenarios	Gollwitzer,  M,  Platzer, et al	Int J Psychol	Public Health response| Interventions de santé publique	This study aimed to illuminate how the general public in Germany reacted to the prospect of increasing the length, the intensity and/or the flexibility of distancing rules implied by different lockdown scenarios. Authors argue that policy-makers and political communicators should take the public's endorsement of and compliance with such scenarios into account, as should simulations predicting the effects of different lockdown scenarios.
An Overall Trend of Headache Remission during COVID-19 Pandemic for Chinese Patients with Pre-existing Headache Highlights the Role of Family Supports	Gong,  Qiaoyu,  Liu, et al	Research Square prepub	Public Health response| Interventions de santé publique	This study investigated the impact of COVID-19 pandemic on headache patients in China. Participants presented an overall trend of headache remission during COVID-19. Family supports played an important role in headache remission.
PMC7592182; [Interdisciplinary COVID board for patients with SARS-CoV-2-triggered hyperferritinemic Inflammation]	Graf La Rosée,  P,  Bremer, et al	Med Klin Intensivmed Notfmed	Clinical data| Données cliniques	Authors discuss the issue of patients with severe COVID-19 develop hyperferritinemic inflammation, a rare sepsis-like immune dysregulation syndrome.  Severe COVID-19 pneumonia with hyperferritinemic inflammation is related to macrophage activation syndrome-like sepsis.
A Descriptive Study of the Implementation of Remote Occupational Rehabilitation Services Due to the COVID-19 Pandemic Within a Workers' Compensation Context	Gross,  DP,  Asante, et al	J Occup Rehabil	Public Health response| Interventions de santé publique Healthcare Response | Réponse des soins de santé	Authors studied WCB-Alberta's transition to remote rehabilitation service delivery to suppress the outbreak of COVID-19. They describe the transition to completely remote delivery of occupational rehabilitation due to COVID-19 physical distancing restrictions in one Canadian compensation jurisdiction.
High Prevalence of Gastrointestinal Manifestations of COVID-19 Infection in Hospitalized Patients With Cancer	Grover,  S,  Redd, et al	J Clin Gastroenterol	Clinical data| Données cliniques	Authors sought to characterize the gastrointestinal (GI) manifestations of coronavirus disease-19 (COVID-19) in oncology patients.  Acute GI symptoms associated with COVID-19 are highly prevalent in hospitalized cancer patients and can occur as a presenting symptom without respiratory symptoms.
Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids	Han,  Y,  Duan, et al	Nature	Clinical data| Données cliniques	Authors developed a lung organoid model using human pluripotent stem cells (hPSC-LOs). Together, these data demonstrate that hPSC-LOs and hPSC-COs infected by SARS-CoV-2 can serve as disease models to study SARS-CoV-2 infection and provide a valuable resource for drug screening to identify candidate COVID-19 therapeutics.
Management of a COVID-19 Patient during ECMO: Paying Attention to Acquired von Willebrand Syndrome	Hayakawa,  M,  Takano, et al	J Atheroscler Thromb	Clinical data| Données cliniques	Authors report a COVID-19 patient who experienced bleeding from AVWS in addition to disseminated intravascular coagulation (DIC) during ECMO.   The patient was successfully treated with cryoprecipitate in bleeding during ECMO without a reduction in heparin, which might have induced thromboembolism.
Controlling COVID-19: Labor structure is more important than lockdown policy	Heroy,  Samuel,  Loaiza, et al	arXiv	Economics | Économie	Countries and cities around the world have resorted to unprecedented mobility restrictions to combat COVID 19-transmission. Here we exploit a natural experiment whereby Colombian cities implemented varied lockdown policies based on ID number and gender to analyse the impact of these policies on urban mobility. Using mobile phone data, we find that the severity of local lockdown rules, measured in the number of days citizens are allowed to go out, does not correlate with mobility reduction. Instead, we find that larger, wealthier cities with a more formalized and complex industrial structure experienced greater reductions in mobility. Commuters are more likely to stay home when their work is located in wealthy or commercially/industrially formalized neighbourhoods. Hence, our results indicate that cities' employment characteristics and workfrom home capabilities are the primary determinants of mobility reduction.
Emergence and spread of a SARS-CoV-2 variant through Europe in the summer of 2020	Hodcroft,  EmmaB,  Zuber, et al	medRxiv	Epidemiology| Épidémiologie	A variant of SARS-CoV-2 emerged in early summer 2020, presumably in Spain, and has since spread to multiple European countries. The variant was first observed in Spain in June and has been at frequencies above 40% since July. Outside of Spain, the frequency of this variant has increased from very low values prior to 15th July to 40-70% in Switzerland, Ireland, and the United Kingdom in September. It is also prevalent in Norway, Latvia, the Netherlands, and France. Little can be said about other European countries because few recent sequences are available. Sequences in this cluster (20A.EU1) differ from ancestral sequences at 6 or more positions, including the mutation A222V in the spike protein and A220V in the nucleoprotein. We show that this variant was exported from Spain to other European countries multiple times and that much of the diversity of this cluster in Spain is observed across Europe. It is currently unclear whether this variant is spreading because of a transmission advantage of the virus or whether high incidence in Spain followed by dissemination through tourists is sufficient to explain the rapid rise in multiple countries.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis work was supported by the SNF through grant numbers 31CA30_196046 (to RAN, EBH) and 31CA30_196267 and core funding by the University of Basel. SeqCOVID-SPAIN is funded by the Instituto de Salud Carlos III project COV20/00140, Spanish National Research Council and ERC StG 638553 to IC.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This is an analysis of publicly available data and no IRB approval is needed.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll sequence data is available on GISAID (gisaid.org), and the code for the analyses performed is available on Github and linked in the manuscript text.https://nextstrain.org/groups/neherlab/ncov/20A.EU1
Loneliness, Mental Health, and Substance Use among US Young Adults during COVID-19	Horigian,  VE,  Schmidt, et al	J Psychoactive Drugs	Public Health response| Interventions de santé publique	This cross-sectional study evaluated relationships of loneliness with depression, anxiety, alcohol use, and drug use during COVID-19, and assessed perceived increases in these symptoms in young adults. Forty-nine percent of respondents reported loneliness scores above 50; 80% reported significant depressive symptoms; 61% reported moderate to severe anxiety; 30% disclosed harmful levels of drinking. While only 22% of the population reported using drugs, 38% reported severe drug use. Loneliness was associated with higher levels of mental health symptomatology. Participants reported significant increases across mental health and substance use symptoms since COVID-19. While direct impacts of COVID-19 could only be calculated with pre-pandemic assessments of these symptoms, estimates indicate elevated psychosocial symptomatology and suggest that symptoms could have worsened since the pandemic. Findings underscore the importance of prevention and intervention to address these public health problems.
PMC7591692; Multidimensional Analysis of Risk Factors for the Severity and Mortality of Patients with COVID-19 and Diabetes	Huang,  J,  Zhu, et al	Infect Dis Ther	Epidemiology| Épidémiologie Clinical data| Données cliniques	In this retrospective study involving 1443 patients with COVID-19, we analyzed the clinical and laboratory characteristics and risk factors associated with disease severity in patients with COVID-19 with and without diabetes. Of the 1443 patients with COVID-19, 256 (17.7%) had diabetes, had a median age of 66.0 [IQR 58.0–73.8] years, and were more likely to develop severe (41.8% vs. 35.6%) and critical disease (34.0% vs. 14.9%), followed by higher mortality (21.1% vs. 7.0%), than those without diabetes. Higher levels of leukocytes (> 5.37 × 109/L), older age, and comorbid cerebrovascular disease and chronic renal disease independently contributed to in-hospital death of patients with COVID-19 and diabetes. Leukocytes > 5.37 × 109/L and the application of immunoglobulin were associated with shorter survival duration and lower mortality, respectively, in critical patients with COVID-19 and diabetes.
Postinfectious Onset of Myasthenia Gravis in a COVID-19 Patient	Huber,  M,  Rogozinski, et al	Frontiers in Neurology	Clinical data| Données cliniques	We report the case of a 21 yr old woman with post-infectious onset of myasthenia gravis after COVID-19 with mild respiratory symptoms and anosmia/ageusia 1 month before admission to our neurological department.
SARS-CoV-2 Positivity Rates among Children of Racial and Ethnic Minority Groups in Mississippi	Inagaki,  K,  Garg, et al	Pediatrics	Epidemiology| Épidémiologie	In this study, we aimed to characterize the positivity rates for severe acute respiratory syndrome coronavirus 2 (SARS86 CoV-2) among children from different racial/ethnic groups in Mississippi.  Minority  children had higher positivity rates (non-Hispanic Black: 15.8%, Hispanic: 24.6%) than in non-Hispanic white children (5.9%) (Table). In multivariable analysis, the risk of non-white race/ethnicity remained substantial.   Rates in Hispanic and other race  children were erratic. Positivity rates in Black and white children increased over time. The rate  of Black children was consistently and considerably higher than that of white children.  Notably, positivity rates in the last 7-8 weeks of the study period (July-August, 2020) were around 20% among non-Hispanic Black children. These data are reflected in the state-wide data  reported to the American Academy of Pediatrics, which has shown that Mississippi is amongst the top in cumulative cases per 100,000 as of the most recent report.
Impact of SARS-Cov-2 Pandemic and Strategies for Resumption of Activities: A Report from Eight Paediatric Hospitals from the ECHO Network	Indolfi,  Giuseppe,  Stivala, et al	SSRN- Lancet prepublication	Healthcare Response | Réponse des soins de santé	The aims of this study were to evaluate the preparedness for the pandemic among a European network of children’s hospitals and to explore the strategies used to restart paediatric health care services. Significant reductions were observed in accesses to the emergency departments (41·7%), outpatient visits (35·7%), intensive and non-intensive care unit inpatient admissions (16·4% and 13%, respectively) between February 1 and April 30, 2020 as compared with the same period of 2019. Overall, 93 children with SARS CoV-2 infection were admitted to inpatient wards. All the hospitals created a multidisciplinary planning committee that developed written SARS-CoV-2 infection preparedness plans for the evaluation, diagnosis and management of confirmed or suspected infected patients. Routine activities were re-scheduled or cancelled. Four hospitals shared their own staff with adult units, two designated bed spaces for adults and only one admitted adults to inpatient wards. The three main components of the strategic planning process for the resumption of clinical activities were testing, source control, and reorganization of spaces and flows of patients. Telemedicine and telehealth services were used before the SARS-CoV-2 pandemic by three hospitals and by all the hospitals during it.
Are meteorological factors enhancing COVID-19 transmission in Bangladesh? Novel findings from a compound Poisson generalized linear modeling approach	Islam,  Armt,  Hasanuzzaman, et al	Environ Sci Pollut Res Int	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	A compound Poisson generalized linear modeling (CPGLM), along with a Monte-Carlo method and random forest (RF) model, was employed to explore how meteorological factors affecting the COVID-19 transmission in Bangladesh. Results showed that subtropical climate (mean temperature about 26.6 °C, mean relative humidity (MRH) 64%, and rainfall approximately 3 mm) enhanced COVD-19 onset. The CPGLM model revealed that every 1 mm increase in rainfall elevated by 30.99% (95% CI 77.18%, − 15.20%) COVID-19 cases, while an increase of 1 °C of diurnal temperature (TDN) declined the confirmed cases by − 14.2% (95% CI 9.73%, − 38.13%) on the lag 1 and lag 2, respectively. In addition, NRH and MRH had the highest increase (17.98% (95% CI 22.5%, 13.42%) and 19.92% (95% CI: 25.71%, 14.13%)) of COVID-19 cased in lag 4. The results of the RF model indicated that TDN and AH (absolute humidity) influence the COVID-19 cases most. In the Dhaka division, MRH is the most vital meteorological factor that affects COVID-19 deaths. This study indicates the humidity and rainfall are crucial factors affecting the COVID-19 case, which is contrary to many previous studies in other countries.
Risk factors associated with morbidity and mortality outcomes of COVID-19 patients on the 28(th) day of the disease course: a retrospective cohort study in Bangladesh	Islam,  MZ,  Riaz, et al	Epidemiol Infect	Epidemiology| Épidémiologie Clinical data| Données cliniques	We conducted this retrospective cohort study with a cohort of  1016 COVID-19 patients diagnosed in May 2020 to identify the risk factors associated with morbidity and mortality outcomes. . Morbidity risk factors included elderly (AOR=2.56, 95% CI=1.31-4.99), having comorbidity (AOR=1.43, 95% CI=0.83-2.47), and smokeless tobacco (SLT) use (AOR=2.17, 95% CI=0.84-5.61). The morbidity risk was higher with COPD (RR=2.68), chronic kidney disease (CKD) (RR=3.33), and chronic liver disease (CLD) (RR=3.99). Mortality risk factors included elderly (AOR=7.56, 95% CI=3.19-17.92), having comorbidity (AOR=5.27, 95% CI=1.88-14.79) and SLT use (AOR=1.93, 95% CI=0.50-7.46). The mortality risk was higher with COPD (RR=7.30), DM (RR=2.63), CHD (RR=4.65), HTN (RR=3.38), CKD (RR=9.03), CLD (RR=10.52), and Malignant diseases (RR=9.73).
In silico analysis of the interactions of certain flavonoids with the receptor-binding domain of 2019 novel coronavirus and cellular proteases and their pharmacokinetic properties	Istifli,  ES,  Netz, et al	J Biomol Struct Dyn	Therapeutics| Thérapeutique	The aim of this study was to investigate the interactions of twenty-three phytochemicals belonging to different flavonoid subgroups with the receptor binding domain (RBD) of the spike glycoprotein of 2019-nCoV, and cellular proteases [transmembrane serine protease 2 (TMPRSS2), cathepsin B and L (CatB/L)]. The compounds interacted more strongly with CatB and CatL than with the other proteins.   As a result of RBCI (relative binding capacity index) analysis conducted to rank flavonoids in terms of their interactions with the target proteins, (-)-epicatechin gallate interacted strongly with all the proteins studied. Although this molecule is not capable of crossing the blood-brain barrier (BBB), it was concluded that (-)-epicatechin gallate can be evaluated as a candidate molecule in drug development studies against 2019-nCoV since it was not the substrate of P-gp (P-glycoprotein), did not inhibit any of the cytochrome Ps, and did not show AMES toxicity or hepatotoxicity on eukaryotic cells.
Deciphering underlying mechanism of Sars-CoV-2 infection in humans and revealing the therapeutic potential of bioactive constituents from Nigella sativa to combat COVID19: in-silico study	Jakhmola Mani,  R,  Sehgal, et al	J Biomol Struct Dyn	Therapeutics| Thérapeutique	The current study deciphered the mechanism of action of Nigella sativa bioactive constituents by protein interaction and docking studies as well as proven their binding efficiency with ACE2 receptor and now this can be studied further in wet lab and be formulated as the medicine to combat the deadly disease COVID-19.
The COVID-19 Own Risk Appraisal Scale (CORAS): Development and validation in two samples from the United Kingdom	Jaspal,  R,  Fino, et al	J Health Psychol	Public Health response| Interventions de santé publique	Perceived risk is an important determinant of the adoption of preventive behaviours. In this article, the psychometric properties of the COVID-19 Own Risk Appraisal Scale (CORAS), including its development and validation in two samples in the United Kingdom, are described. The CORAS is a measure of perceived personal risk of contracting the disease, incorporating primarily intuitive with some analytic risk estimates. Exploratory and confirmatory factor analyses were performed on data from 470 participants in the United Kingdom who completed the CORAS, the Fear of COVID-19 Scale and the COVID-19 Preventive Behaviours Index. Results showed that a unidimensional, six-item model fits the data well, with satisfactory fit indices, internal consistency and high item loadings onto the factor. We found no statistically significant differences by age, gender or ethnicity. The CORAS correlated positively with the Fear of COVID-19 Scale and the COVID-19 Preventive Behaviours Index, suggesting good concurrent validity.
33070483; Three Cases of COVID-19-related First Onset Brief Reactive Psychosis	Jaworowski,  S,  Weiser, et al	The Israel Medical Association journal : IMAJ	Clinical data| Données cliniques	We present three cases of first onset, transient psychosis in male patients diagnosed with coronavirus disease-19 (COVID-19). In all cases the psychosis resolved over the course of 2 days with parenteral neuroleptic medication. There was no pre-existing history of mental illness in any of the patients. To the best of our knowledge, this is the first report of first onset psychosis associated with COVID-19.
Chronic diseases: An added burden to income and expenses of chronically-ill people in Sri Lanka	Jayathilaka,  R,  Joachim, et al	PLoS One	Epidemiology| Épidémiologie	This paper investigates the differences in the level of income and expenditure between chronically-ill people and non-chronic population in Sri Lanka. the study discovered that married females who do not engage in any type of economic activity (being unemployed due to the disability associated with the respective chronic illness), in the age category of 40–65, having an educational level of tertiary education or below and living in the urban sector have a higher likelihood of suffering from chronic diseases. If workforce population is compelled to lose jobs, it can lead to income insecurity and impair their quality of lives. Under above findings, it is reasonable to assume that most health care expenses are out of pocket. Furthermore, the study infers that chronic illnesses have a statistically proven significant differences towards the income and expenditure level. This has caused due to the interaction of demographic and socio-economic characteristics associated with chronic illnesses.
CoVID-19: Parent and caregiver concerns about reopening New Zealand schools	Jeffs,  E,  Lucas, et al	J Paediatr Child Health	Public Health response| Interventions de santé publique	The aims of this study were to investigate parents' and caregivers' knowledge of CoVID‐19 in children, to understand their levels of concern and to identify their most trusted sources of information. Of the 1191 study participants, 721 (60%) expressed some level of worry (14.5% very or extremely worried) that their child would catch CoVID‐19 at school. A high proportion (79%, 941) thought it likely or very likely that their child would catch CoVID‐19 at school if there were to be widespread community transmission. Fear scores for CoVID‐19 were generally high, and 828 (80%) of participants said they would vaccinate their child if a newly developed vaccine were available.
Evaluation of the Abbott Architect, Roche Elecsys and Virtus S1 SARS-CoV-2 antibody tests in community-managed COVID-19 cases	Johnston,  SebastianL,  McKay, et al	medRxiv	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	Virtus Respiratory Research Ltd (Virtus) has developed its own quantitative IgM and IgG SARS CoV-2 antibody assay. We report its validation and performance characteristics and compare its performance with the Abbott Architect and Roche Elecsys assays in community COVID cases. The Abbott and Roche tests had sensitives of 68% and 69% respectively in this community set of COVID-19 sera, while the Virtus test had sensitivities of 87% and 91% in the same sample sets. The strong positive correlation with virus neutralization suggests a positive Virtus quantitative antibody test is likely predictive of protective against recurrent COVID-19.
Common childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2	Kandeil,  A,  Gomaa, et al	PLoS One	Immunology | Immunologie Animal model | Modèle animal	Here, we tested whether BCG, Pneumococcal, Rotavirus, Diphtheria, Tetanus, Pertussis, Hepatitis B, Haemophilus influenzae, Hepatitis B, Meningococcal, Measles, Mumps, and Rubella vaccines provide cross-reactive neutralizing antibodies against SARS-CoV-2 in BALB/c mice. Results indicated that none of these vaccines provided antibodies capable of neutralizing SARS-CoV-2 up to seven weeks post vaccination.
33070499; The Effects of Border Shutdowns on the Spread of COVID-19	Kang,  N,  Kim, et al	Journal of preventive medicine and public health = Yebang Uihakhoe chi	Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	We sought to identify the effects of border shutdowns on the spread of the COVID-19 outbreak. The border shutdowns in early February significantly reduced the spread of the virus.
Knowledge and attitude of pakistani dentists regarding COVID-19	Khan,  AM,  Riaz, et al	Medical Forum Monthly	Healthcare Response | Réponse des soins de santé	The objective of the study was to examine the knowledge, and attitude of Pakistani dentists, regarding novel COVID-19 disease.  A total of 306 dentists responded. Pakistani dentists have exhibited adequate awareness about general symptoms, transmission mode, cross-infection control and dental practice management in perspective of the COVID-19 outbreak. However, their understanding to protect dental professionals from this highly contagious disease during specialized dental procedures was unsatisfactory.
Mechanism of SARS-CoV-2 polymerase inhibition by remdesivir	Kokic,  Goran,  Hillen, et al	bioRxiv	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Here we use synthetic RNA chemistry, biochemistry and cryo-electron microscopy to establish the molecular mechanism of remdesivir-induced RdRp stalling. We show that addition of the fourth nucleotide following remdesivir incorporation into the RNA product is impaired by a barrier to further RNA translocation. This translocation barrier causes retention of the RNA 3'-nucleotide in the substrate-binding site of the RdRp and interferes with entry of the next nucleoside triphosphate, thereby stalling RdRp. In the structure of the remdesivir-stalled state, the 3'-nucleotide of the RNA product is matched with the template base, and this may prevent proofreading by the viral 3'-exonuclease that recognizes mismatches.
Corona-Independent Excess Mortality Due to Reduced Use of Emergency Medical Care in the Corona Pandemic: A Population-Based Observational Study	Kortuem,  StefanO,  Frey, et al	medRxiv	Healthcare Response | Réponse des soins de santé	The present study investigates changes in the use of preclinical and clinical emergency care and effects on overall mortality in a rural area. Overall, the number of patients in clinical and preclinical emergency care declined significantly during the investigation period. This concerned in particular emergency inpatient treatment of patients with exacerbations or complications of severe chronic diseases. At the same time, excess mortality occurred in April 2020, which was still highly significant even after excluding deaths on or with COVID-19.
33055326; MASKS - PROTECTION OR DANGER? ANALYSIS OF SOCIAL ATTITUDES TOWARDS THE ORDER TO COVER MOUTH AND NOSE DURING THE COVID-19 PANDEMIC [ARTICLE IN POLISH]	Krzyżak,  K,  Kościelecka, et al	Wiadomosci lekarskie (Warsaw, Poland : 1960)	Public Health response| Interventions de santé publique	The aim: To analyze social behaviour towards the order to cover the nose and mouth during the SARS-CoV-2 pandemic. The study involved a group of 2512 respondents from all over Poland. 76.1% of the respondents declare that they always obey the current order. 83% use a material mask and 26.9% wear a surgical mask. 35.2% of respondents think that the order to cover their nose and mouth is not justified.
33055329; RETROSPECTIVE ANALYSIS OF INTERVENTIONS PERFORMED BY EMERGENCY MEDICAL TEAMS IN POLAND BEFORE AND DURING THE SARS COV-2 PANDEMIC	Kucap,  M,  Nadolny, et al	Wiadomosci lekarskie (Warsaw, Poland : 1960)	Healthcare Response | Réponse des soins de santé	The aim: To analyze interventions of emergency medical teams during the SAR-CoV-2 pandemic, and to compare obtained data with the same periods in 2018-2019. Authors observed the decline in the number of interventions performed by emergency medical teams during the pandemic in relation to earlier years by approximately 25%. The big decline concerned interventions that were the reason for calls to public places, such as "traffic accident" and "collapse". In the case of diagnoses made by the head of the emergency medical team, the diagnoses regarding stroke or sudden cardiac arrest remained at the similar level. Others showed a marked decline.
Generalized exanthema due to hydroxychloroquine as a popular drug during COVID-19 prophylaxis	Kutlu,  O,  Özdemir Çetinkaya, et al	Int J Clin Pract	Clinical data| Données cliniques	Herein, we reported generalized exanthema after a single dose of using HCQ. A 58-year-old male patient presented with resistant rashes on his upper extremities and neck region. Rashes appeared all over the body along with severe pruritus just a day after receiving a single 200 mg dose of oral hydroxychloroquine for COVID-19 prophylaxis.
Explaining factors affecting telework adoption in South African organisations pre-COVID-19	Lebopo,  CM,  Seymour, et al		Public Health response| Interventions de santé publique	This study is an empirical investigation of telework adoption, using a set of factors identified in the literature in organisations in a South African context. These factors in prior studies were found to enable or prevent an organisation from adopting telework. The question thus asked in this study was "Which factors enable or prevent the adoption of telework within South African organisations?"A survey with 104 valid responses was analysed using Statistica. The theoretical contribution of the study is a validated model of factors influencing the adoption of telework.
ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs	Lee,  IT,  Nakayama, et al	Nat Commun	Clinical data| Données cliniques	We investigate the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of human donors using a diverse panel of banked tissues. Here, we report our discovery that the ACE2 receptor protein robustly localizes within the motile cilia of airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during host respiratory transmission. We further determine whether ciliary ACE2 expression in the upper airway is influenced by patient demographics, clinical characteristics, comorbidities, or medication use, and show the first mechanistic evidence that the use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARBs) does not increase susceptibility to SARS-CoV-2 infection through enhancing the expression of ciliary ACE2 receptor.
Characteristics and outcome profile of Hospitalized African COVID-19 patients: The Ethiopian Context	Leulseged,  TigistW,  Hassen, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques	Aim: To assess the characteristics and outcome of COVID-19 patients and to identify determinants of the disease outcome among patients admitted to Millennium COVID-19 Care Center in Ethiopia. The average duration of time to clinical improvement was 14 days and 89.4 % of the patients achieved clinical improvement. The mortality rate of the studied population is lower than reports from other countries including those in Africa. Having severe COVID-19 disease severity and presenting with cough were found to be associated with delayed clinical improvement ofthe disease. On the other hand, being hyperthermic is associated with shorter disease duration (faster time to clinical improvement). In addition, lower oxygen saturation and subjective complaint of shortness of breath and being diabetic were associated with unfavorable disease outcome.
Impact of Pre-symptomatic Transmission on Epidemic Spreading in Contact Networks	Li,  Bo,  Saad, et al	arXiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	This framework provides a good estimate of the probabilistic evolution of the spread on both static and contact networks at a low computational cost compared to numerical simulation. Our studies show quantitatively the deficiency of using the reproduction number as a measure for predicting the spreading rate in some topologies, how effective isolation reduces the need in strict social distancing measures, and the importance of mass testing in scenarios with long asymptomatic exposure since isolation of symptomatic individuals is insufficient to mitigate the spread.
Impact of Lifestyle Alteration on Non-COVID Deaths by Prevention Measures in the Region with a Low COVID-19 Transmission Rate	Li,  Chengzong,  Wang, et al	SSRN- Lancet prepublication	Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	The increase of all-cause mortality in the areas with high COVID-19 transmission rate due to COVID-19 deaths and the collateral damage to other healthcare problems is well-known. However, the COVID-19 mortality is low in the regions with a low transmission rate and sufficient medical resources. Our results show that control strategies in the region of low SARS-CoV-2 transmission rate during the COVID-19 outbreak alter the lifestyles of people and further exert an impact on non-COVID deaths, which could have a practical value in guiding clinical work and future management of chronic diseases.
Ethacridine inhibits SARS-CoV-2 by inactivating viral particles in cellular models	Li,  Xiaoquan,  Lidsky, et al	bioRxiv	Therapeutics| Thérapeutique	Here we report that ethacridine, a safe and potent antiseptic use in humans, effectively inhibits SARS-CoV-2, at very low concentrations (EC50 ~ 0.08 μM). Ethacridine was identified through a high-throughput screening of an FDA-approved drug library in living cells using a fluorescent assay. Interestingly, the main mode of action of ethacridine is to inactivate virus particles, preventing binding to the host cells. Thus, our work has identified a potent drug with a distinct mode of action against SARS-CoV-2.
The Association of Incidence of Face-Touching Behaviors with Masks Wearing Rates During the Coronavirus Disease 2019 Pandemic	Li,  Xing,  Li, et al	SSRN- Lancet prepublication	Public Health response| Interventions de santé publique	Videos displaying mask-wearing and face-touching behaviors of general population in public areas were analyzed. The incidence of face touching behaviors of general population in public areas was negatively associated with mask wearing rates. However, Mandatory mask wearing polices were risky in population with low adherence to masks, among whom, the face touching behaviors in public areas might increase with mask wearing rates rise.
Aglycone polyether ionophores as broad-spectrum agents inhibit multiple enveloped viruses including SARS-CoV-2 in vitro and successfully cure JEV infected mice	Liu,  Tiangang,  Li, et al	bioRxiv	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Here, we show that the maduramycin and CP-80,219 aglycone polyether ionophores exhibit effective broad-spectrum antiviral activity, against various viruses, including Japanese encephalitis virus (JEV), Dengue virus (DENV), Zika virus (ZIKV), and Chikungunya virus (CHIKV), while also exhibiting promising activity against PR8 influenza virus and SARS-CoV-2.
Multivariate mortality analyses in COVID-19: Comparing patients with cancer and patients without cancer in Louisiana	Lunski,  MJ,  Burton, et al	Cancer	Epidemiology| Épidémiologie	The objective was to assess COVID‐19 mortality rates in patients with cancer versus patients without cancer and uncover possible statistically significant characteristics contributing to mortality. Patients with cancer have increased mortality in the setting of infection with SARS‐CoV‐2 in comparison with patients without cancer. Patients with cancer who are 65 years of age or older and those with certain comorbidities have the greatest risk of death.
Will vaccination refusal prolong the war on SARS-CoV-2?	Marcec,  R,  Majta, et al	Postgrad Med J	Public Health response| Interventions de santé publique	We collected public opinion survey results about attitudes towards SARS-CoV-2 vaccination conducted in 2020 in 26 European countries. The pooled surveys were conducted on a total of 24 970 participants; on average only 58% (n=14 365/24 970) of responders across Europe were willing to get a SARS-CoV-2 vaccine once it becomes available, 16% (n=3998/24 970) were neutral, and 26% (n=6607/24 970) were not planning to vaccinate against SARS-CoV-2. Such a low vaccination response could make it exceedingly difficult to reach the herd immunity threshold for SARS-CoV-2 through vaccination.
Optimal Strategies to Screen Health Care Workers for COVID-19 in the US with SARS-CoV-2 PCR and IgG Antibody Assays	Maya,  Sigal,  Padda, et al	SSRN- Lancet prepublication	Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins de santé	We undertook a cost-effectiveness analysis to determine optimal testing strategies for screening HCWs to inform strategic decision-making in health care settings. PCR testing is a beneficial strategy to identify infected HCWs and reduce transmission of SARS-CoV-2 in health care settings. Utility of IgG testing depends on the time when the test is administered and immunity characteristics.
33055355; A SINGLE NEGATIVE SARS-COV2 RT-PCR TEST DOES NOT EXCLUDE COVID-19 IN PATIENT WITH SEVERE ARDS, CASE STUDY	Mendrala,  K,  Skoczyński, et al	Wiadomosci lekarskie (Warsaw, Poland : 1960)	Clinical data| Données cliniques	The aim of this case study is to demonstrate that singular negative RT-PCR test for SARS-CoV-2 in symptomatic patient, should not be considered as conclusive.
SARS-CoV-2 Prevalence in Saliva and Gastric and Intestinal Fluid in Patients Undergoing Gastrointestinal Endoscopy in COVID-19 Endemic Areas: Prospective Cross-Sectional Study in Japan	Miyake,  Shigeta,  Ashikari, et al	SSRN- Lancet prepublication	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study aimed to explore the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positivity in saliva and gastric and intestinal fluids to which endoscopy medical staff are exposed. The primary outcome was the positive rate of SARS-CoV-2 in saliva and gastric and intestinal fluids. We also analyzed serum-specific antibodies for SARS-CoV-2 and patients’ background information. Asymptomatic patients, even those with no detectable virus in their saliva, had SARS-CoV-2 in their gastrointestinal tract. Endoscopy medical staff should be aware of infection when performing procedures.
Parents and Children During the COVID-19 Lockdown: The Influence of Parenting Distress and Parenting Self-Efficacy on Children’s Emotional Well-Being	Morelli,  M,  Cattelino, et al	Frontiers in Psychology	Public Health response| Interventions de santé publique	The present study aimed to investigate parental correlates of children’s emotion regulation during the COVID-19 lockdown. Results suggested how parents’ beliefs to be competent in managing parental tasks might be a protective factor for their children’s emotional well-being.
Telemedicine, Patient Satisfaction, and Chronic Rhinosinusitis Care in the Era of COVID-19	Morisada,  MV,  Hwang, et al	Am J Rhinol Allergy	Healthcare Response | Réponse des soins de santé	This study compares patient satisfaction scores between in-person clinic visits and telemedicine video visits in patients with chronic rhinosinusitis (CRS). Patient satisfaction with telemedicine in the COVID-19 pandemic parallels that of traditional in-person visits. Video visits can serve as a viable alternative to clinic visits, while still maintaining high satisfaction.
Comparison of Two Commercial Surrogate Elisas to Detect a Neutralizing Antibody Response to SARS-CoV-2	Müller,  Katharina,  Girl, et al	SSRN- Lancet prepublication	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	In this study, we investigated two commercial sELISA kits (GenScript, AdipoGen) designed for the detection of SARS-CoV-2 NAbs. Both sELISA were able to qualitatively detect NAbs in plasma samples. Sensitivity and specificity differed between sELISA with GenScript superior in sensitivity and AdipoGen superior in specificity. Both sELISA were unable to quantify NAbs, thus neither of them can completely replace conventional NTs.
A large national outbreak of COVID-19 linked to air travel, Ireland, summer 2020	Murphy,  N,  Boland, et al	Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin	Epidemiology| Épidémiologie Transmission Coronavirology| Coronavirologie	An outbreak of 59 cases of coronavirus disease (COVID-19) originated with 13 cases linked by a 7h, 17% occupancy flight into Ireland, summer 2020. The flight-associated attack rate was 9.8-17.8%. Spread to on-flight cases occurred country-wide. Asymptomatic/pre-symptomatic transmission in-flight from a point source is implicated by 99% homology across the virus genome in five cases travelling from three different continents. Restriction of movement on arrival and robust contact tracing can limit propagation post-flight.
Encephalopathy associated with COVID-19 in a patient with multiple sclerosis	Naser Moghadasi,  A	J Neurovirol	Clinical data| Données cliniques	Although various reports are published on affliction of multiple sclerosis (MS) patients with SARS-CoV-2, no report has been published on brain involvement by this virus in MS patients so far. Herein, a 34-year-old patient with MS who experienced the decreased level of consciousness and encephalopathy following COVID-19 involvement has been reported.
Pro- and Anti-Inflammatory Responses in Severe COVID-19-Induced Acute Respiratory Distress Syndrome—An Observational Pilot Study	Notz,  Q,  Schmalzing, et al	Frontiers in Immunology	Epidemiology| Épidémiologie Clinical data| Données cliniques	In the current study we characterized the immune responses in patients suffering from severe COVID-19-induced acute respiratory distress syndrome (ARDS). All patients suffered from severe ARDS, 30.8% died. Massively elevated levels of IL-6 and a delayed cytotoxic immune defense characterized severe COVID-19-induced ARDS. The B cell response and antibody production were largely unimpeded. No obvious imbalance of pro- and anti-inflammatory mechanisms was observed, with elevated GDF-15 levels suggesting increased tissue resilience.
Modelling the Spread of COVID-19 in New York City	Olmo,  Jose,  Sanso-Navarro, et al	SSRN- Lancet prepublication	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	This paper proposes a methodology to predict the increase in the number of confirmed COVID-19 cases in the city of New York at the zip code level.  To do this, we propose a Poisson regression model for count data that includes a large set of covariates reflecting socioeconomic conditions at neighbourhood level and spatial effects. Our pointwise forecasts display reasonable mean square prediction errors and the associated interval forecasts accurate empirical coverage probabilities suggesting the suitability of the methodology for prediction of the number of infections.
Occupational dermatoses during the Covid-19 pandemic: a multicentre audit in the UK and Ireland	O'Neill,  H,  Narang, et al	Br J Dermatol	Healthcare Response | Réponse des soins de santé	The British Society of Cutaneous Allergy has conducted the first UK-wide prospective audit of occupational dermatoses in HCWs during the Covid-19 pandemic. Eleven centres in the UK and Ireland set up dedicated occupational skin disease clinics to treat PPE-related. Our data support reports of increased cutaneous morbidity in HCWs during the Covid-19 pandemic, and identify trends which may aid preventive strategies in workforce planning and skin protection measures.
33060148; Impact of COVID-19 outbreak on cancer immunotherapy in Italy: A survey of young oncologists	Ottaviano,  M,  Curvietto, et al	Journal for ImmunoTherapy of Cancer	Healthcare Response | Réponse des soins de santé	Data regarding the impact of COVID-19 on cancer patients (CPs) undergoing or candidate for immune checkpoint inhibitors (ICIs) are lacking. We depicted the practice and adaptations in the management of patients with solid tumors eligible or receiving ICIs during the COVID-19 pandemic, with a special focus on Campania region of Italy. The COVID-19 pandemic seemed not to affect the standard practice in the prescription and delivery of ICIs in Italy. Telemedicine was widely used. There was high consensus to interrupt immunotherapy in SARS-CoV-2-positive patients and to adopt ICIs with longer schedule interval.
Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multi-national cohort	Papadopoulos,  NikolaosG,  Mathioudakis, et al	medRxiv	Public Health response| Interventions de santé publique	We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes. Childhood asthma outcomes, including control, were improved during the first wave of the COVID-19 pandemic, probably because of reduced exposure to asthma triggers and increased treatment adherence. The decreased frequency of acute episodes does not support the notion that childhood asthma may be a risk factor for COVID-19. Furthermore, the potential for improving childhood asthma outcomes through environmental control becomes apparent.
Investigating the association between ethnicity and health outcomes in SARS-CoV-2 in a London secondary care population	Patel,  A,  Abdulaal, et al	PLoS One	Epidemiology| Épidémiologie Clinical data| Données cliniques	We investigated the relationship between ethnicity and health outcomes in SARS-CoV-2. We conducted a retrospective, observational analysis of SARS-CoV-2 patients across two London teaching hospitals during March 1 -April 30, 2020.   Black, Asian and minority ethnic (BAME) patients were more likely to be admitted younger, and to die at a younger age with SARS-CoV-2. Within the BAME cohort, Asian patients were more likely to die but despite this, there was no difference in rates of admission to ICU.
Barriers and Facilitators to Mood and Confidence in Pregnancy and Early Parenthood During COVID-19: A Mixed-Methods Synthesis Survey	Perez,  Alejandra,  Panagiotopoulou, et al	SSRN- Lancet prepublication	Public Health response| Interventions de santé publique	We examined how COVID-19 and associated restrictions influence mood and parenting confidence of expectant parents and those in early parenthood, identifying barriers and facilitators.  A decrease in mood and parenting confidence were found. Barriers included practical difficulties (finding essentials, reliable health information), social difficulties (loss of physical contact, decreased support), and uncertainty during pregnancy.
Impacts of reopening strategies for COVID-19 epidemic: a modeling study in Piedmont region	Pernice,  S,  Castagno, et al	BMC Infect Dis	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	This study presents an extended version of the Susceptible-Exposed-Infected-Removed-Susceptible (SEIRS) model accounting for population age structure. The proposed model allows us to investigate different scenarios of the COVID-19 spread in Piedmont and the implementation of different infection-control measures and testing approaches. The results show that the implemented control measures have proven effective in containing the epidemic, mitigating the potential dangerous impact of a large proportion of undetected cases. We also forecast the optimal combination of individual-level measures and community surveillance to contain the new wave of COVID-19 spread after the re-opening work and social activities.
Early Tocilizumab Dosing is Associated with Improved Survival In Critically Ill Patients Infected With Sars-CoV-2	Petrak,  Russell,  Van Hise, et al	medRxiv	Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique	We studied 118 patients who required mechanical ventilation. Eighty-one (81) received tocilizumab, compared to 37 who were untreated. Early tocilizumab therapy was associated with a statistically significant decrease in mortality as compared to patients who were untreated (p=0.003). Dosing tocilizumab late was associated with an increased mortality compared to the untreated group (p=0.006).
Extracellular vesicle-based vaccine platform displaying native viral envelope proteins elicits a robust anti-SARS-CoV-2 response in mice	Polak,  Katarzyna,  Greze, et al	bioRxiv	Vaccine Research| Recherche sur les vaccins	In this study, we applied our technology in natural sxtracellular vesicles (EV's) engineering, to express the S proteins of SARS-CoV-2 embedded in the EVs, which mimic the virus with its fully native spikes. Immunizations with a two component CoVEVax vaccine, comprising DNA vector (DNAS-EV) primes, allowing in situ production of Spike harbouring EVs, and a boost using S-EVs produced in mammalian cells, trigger potent neutralizing and cellular responses in mice, in the absence of any adjuvants. CoVEVax would be the prototype of vaccines, where the sole exchange of the envelope proteins on EVs leads to the generation of new vaccine candidates against emerging viruses.
33062702; Protecting Healthcare Professionals during the COVID-19 Pandemic	Qi,  B,  Peng, et al	BioMed research international	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	The aim of this study is to understand how to implement proactive prevention measures among healthcare professionals for preventing potential nosocomial infection. 91 healthcare professionals confirmed with the COVID-19 infection were collected, and clinical characteristics and epidemiological data were evaluated. 73 of a total of 91 cases (80.2%) with a median incubation period of 3 days (IQR, 2 to 6) reported close contact history with patients with the COVID-19 infection. In the early stage, the most common route of exposure to COVID-19 was via direct care in the absence of any invasive procedure. By contrast, 37 healthcare professionals infected with COVID-19 in the late stage were confirmed to have been exposed via aerosol-generating procedures. Identification of the asymptomatic individuals in healthcare settings and prompt response when a suspicious case is considered may render effective control of the nosocomial infection during this pandemic.
Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against COVID-19: Jacalin-RBD COVID-19 interaction	Rajendaran,  S,  Jothi, et al	Royal Society Open Science	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	In silico analysis revealed that a lectin, jacalin from jackfruit seeds, recognizes a glycosylated region of the receptor-binding domain (RBD) of SARS-CoV2. Jacalin binding induces conformational changes in RBD and significantly affects its interaction with human angiotensin-converting enzyme 2. The result may open up exploration of lectin-based strategies against COVID-19. © 2020 The Authors.
Stoic or Dread? Exploring Reactions to the COVID-19 Pandemic	Rao Seshadri,  Shreelata,  Seshadri, et al	SSRN- Lancet prepublication	Public Health response| Interventions de santé publique	This exploratory study seeks to capture the response of people to the several extraordinary measures taken by the government in the wake of the COVID-19 pandemic. Data was collected through a online survey and analyzed respondents’ self-report of feelings along a spectrum – named the ‘Dread-Stoic Index’ – based on their (a) affective response to actions taken by the government; and (b) understanding of drivers of government pandemic policy. We found that more Stoic respondents were more likely to see government action as necessary, based on good science, and fair and equitable. Those who were more Dread not only felt significantly differently on the above dimensions, they (in addition) felt that the government was acting in response to global pressure rather than in consultation with national/local entities. Our findings show that India cannot continue to rely on a 125-year old Epidemic Diseases Act. We need a legal architecture that not only spells out the conditions under which the State can intervene in a public health emergency, but that also safeguards citizen’s ‘liberty, movement, privacy and property’.
SARS-CoV-2 replication triggers an MDA-5-dependent interferon production which is unable to efficiently control replication	Rebendenne,  Antoine,  Chaves Valadão, et al	bioRxiv	Coronavirology| Coronavirologie Immunology | Immunologie	In this study we further characterized the host cell antiviral response against SARS-CoV-2 by using primary human airway epithelia and immortalized model cell lines. We mainly focused on the type I and III interferon (IFN) responses, which lead to the establishment of an antiviral state through the expression of IFN-stimulated genes (ISGs). Our results demonstrate that both primary airway epithelial cells and model cell lines elicit a robust immune response characterized by a strong induction of type I and III IFN through the detection of viral pathogen molecular patterns (PAMPs) by melanoma differentiation associated gene (MDA)-5. However, despite the high levels of type I and III IFNs produced in response to SARS-CoV-2 infection, the IFN response was unable to control viral replication, whereas IFN pre-treatment strongly inhibited viral replication and de novo production of infectious virions. Taken together, these results highlight the complex and ambiguous interplay between viral replication and the timing of IFN responses.
Performance of a Severity Score on Admission Chest Radiograph in Predicting Clinical Outcomes in Hospitalized Patients with Coronavirus Disease (COVID-19)	Reeves,  RA,  Pomeranz, et al	AJR Am J Roentgenol	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	The aim of this study is to assess the performance of a severity scoring system on admission chest radiograph (CXR) in predicting hospital outcomes in patients admitted with COVID-19. This retrospective study included 240 patients admitted to the hospital from 3/16/2020 to 4/30/2020 with COVID-19 confirmed by real-time reverse transcriptase-polymerase chain reaction and who underwent CXR within 24 hours of admission. Three chest radiologists and three radiology residents independently scored patients' admission CXR using a 0 to 24-point composite scale. Interrater reliability of the CXR scores ranged from 0.687 to 0.737 for attendings, 0.653 to 0.762 for residents, and 0.575 to 0.666 for all readers combined. For patients admitted with COVID-19, a simple admission CXR severity score may help predict hospital mortality, intubation, and CRRT.
Predictive modeling of virus inactivation by UV	Rockey,  NicoleC,  Chin, et al	bioRxiv	Modelling/ prediction| Modélisation/prédiction Coronavirology| Coronavirologie	This study conducted a rapid systematic literature review to collect high-quality inactivation rate constants for a wide range of viruses. using these data they developed and evaluated four different model classes, including linear and non-linear approaches, to find the top performing prediction model for kinetics of virus inactivation by UV254. We tested the models by predicting and measuring inactivation rate constants for two viruses that were not identified in our systematic review, including a (+) ssRNA mouse coronavirus and a dsDNA marine bacteriophage; the predicted rate constants were within 7% and 71% of the experimental rate constants, respectively. Our models will be valuable for predicting inactivation kinetics of emerging or difficult-to-culture viruses.
"Goodness and kindness": Long distance caregiving through volunteers during the COVID-19 lockdown in India	Roy,  S,  Ayalon, et al	J Gerontol B Psychol Sci Soc Sci	Public Health response| Interventions de santé publique	A pan-India group of volunteers was formed during the lockdown on a popular social media website to connect people of all ages in need of help with those able to offer assistance. A sample of 242 messages pertaining to older adults was extracted for quantitative content analysis.  All but two requests were placed by adult relatives of older adults. Requests covered a number of needs, some of which were directly tied to the pandemic and lockdown, while others were general in nature but were greatly exacerbated by recent events. The use of social media to encourage acts of kindness at a time of crisis was an innovative attempt to meet the immediate needs of older adults. The lockdown, however, exposed the lack of dedicated supports and services for older adults in India.
Biophysical analysis of SARS-CoV-2 transmission and theranostic development via N protein computational characterization	Sabbih,  GO,  Korsah, et al	Biotechnol Prog	Coronavirology| Coronavirologie	This article describes the development of an intrinsic model to describe the incubation characteristics of the virus under varying environmental factors. It also discusses on the evaluation of SARS-CoV-2 structural nucleocapsid protein properties via computational approaches to generate high-affinity binding probes for effective diagnosis and targeted treatment applications by specific targeting of viruses. In addition, this article provides useful insights on the transmission behavior of the virus and create new opportunities for theranostics development.
5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro	Sakurai,  Yasuteru,  Tun, et al	bioRxiv	Therapeutics| Thérapeutique	In this study, we demonstrated that 5-amino levulinic acid (5-ALA) treatment potently inhibited infection of SARS-CoV-2, a causative agent of COVID-19. The antiviral effects could be detected in both human and non-human cells, without significant cytotoxicity. Therefore, 5-ALA is a candidate as an oral antiviral drug for COVID-19.
Implications of COVID-19-induced nationwide lockdown on children's behaviour in Punjab, India	Sama,  BK,  Kaur, et al	Child: Care, Health and Development	Public Health response| Interventions de santé publique	In this study, efforts were to understand the impacts of lockdown on the mental status of the children of India and their specific causes. A web-based questionnaire was prepared, and 400 parents from four districts of Punjab, India, namely, Ludhiana, Sahibzada Ajit Singh (SAS) Nagar, Sangrur and Ferozepur, were telephonically interviewed. dings from this study revealed that 73.15% and 51.25% of the children were having signs of increased irritation and anger, respectively; 18.7% and 17.6% of the parents also mentioned the symptoms of depression and anxiety, respectively, among their children, which were also augmented by the changes in their diet, sleep, weight and more usage of the electronic equipment. This study made it evident that the mental health of the children residing in Punjab, India, was compromised during the lockdown period induced by the COVID-19 pandemic.
Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-α with in-vitro effective drug ivermectin	Sen Gupta,  PS,  Biswal, et al	J Biomol Struct Dyn	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	Among 12 different COVID-19 targets along with Importin-α studied here, the RNA dependent RNA polymerase (RdRp) with RNA and Helicase NCB site show the strongest affinity to Ivermectin amounting -10.4 kcal/mol and -9.6 kcal/mol, respectively, followed by Importin-α with -9.0 kcal/mol. Molecular dynamics of corresponding protein-drug complexes reveals that the drug bound state of RdRp with RNA has better structural stability than the Helicase NCB site and Importin-α, with MM/PBSA free energy of -187.3 kJ/mol, almost twice that of Helicase (-94.6 kJ/mol) and even lower than that of Importin-α (-156.7 kJ/mol). The selectivity of Ivermectin to RdRp is triggered by a cooperative interaction of RNA-RdRp by ternary complex formation. Identification of the target and its interaction profile with Ivermectin can lead to more powerful drug designs for COVID-19 and experimental exploration.
Risk of hospital admission with coronavirus disease 2019 in healthcare workers and their households: nationwide linkage cohort study	Shah,  ASV,  Wood, et al	Bmj	Epidemiology| Épidémiologie	The aim of the study is to assess the risk of hospital admission for coronavirus disease 2019 (covid-19) among patient facing and non-patient facing healthcare workers and their household members. This nationwide linkage cohort study was conducted in Scotland, UK between March 1, 2020 to June 6, 2020. The cohort comprised 158 445 healthcare workers, most of them (90 733; 57.3%) being patient facing, and 229 905 household members. Healthcare workers and their households contributed a sixth of covid-19 cases admitted to hospital. Although the absolute risk of admission was low overall, patient facing healthcare workers and their household members had threefold and twofold increased risks of admission with covid-19.
Experience repatriation of citizens from epicentre using commercial flights during COVID-19 pandemic	Shaikh Abdul Karim,  S,  Md Tahir, et al	Int J Emerg Med	Epidemiology| Épidémiologie Public Health response| Interventions de santé publique	Between February and April 2020, the Government of Malaysia directed repatriation of its citizens from China, Iran, Italy and Indonesia. We describe the preparation and execution of the repatriation mission using chartered commercial aircraft. The mission objectives were to repatriate as many citizens based on aircraft capacity and prevent onboard transmission of the disease to flight personnel. Five repatriation missions performed was led by the National Agency for Disaster Management (NADMA) with the Ministry of Health providing technical expertise. A total of 432 citizens were repatriated from the missions. There were 82 positive cases detected among the repatriated citizens. There was a single positive case of a healthcare worker involved in the mission, based on the sample taken on arrival of the flight. There were no infections involving flight team members.
Pustular psoriasis exacerbated by COVID-19 in a patient with the history of psoriasis	Shakoei,  S,  Ghanadan, et al	Dermatol Ther	Clinical data| Données cliniques	This is a case study of a 47-year old woman presenting with pustular lesions and who tested positive for COVID-19. She was treated with hydroxychloroquine (400 mg twice on the first day and then 200 mg twice for the next four days). However, she had continued the use of hydroxychloroquine (200 mg) daily for five weeks. The woman was diagnosed with pustular psoriasis four years ago and was treated with methotrexate for one year. The lesions had developed three weeks after the emergence of COVID-19 symptoms and had gradually progressed. This was the first reported case of pustular psoriasis, exacerbated by  COVID-19. Although the patient had used hydroxychloroquine, she had a history of hydroxychloroquine use without exacerbation of psoriasis; therefore, it seems that COVID-19 led to the psoriasis flare-up.
Long-Lasting Alterations in T and B Cell Function in Convalescent COVID-19 Patients	Shuwa,  Halima Ali,  Shaw, et al	SSRN- Lancet prepublication	Clinical data| Données cliniques Immunology | Immunologie	The long-term immune response in COVID-19 patients presently remains ill-defined. This article describes the phenotypic and functional characteristics of B and T cells in healthy individuals and individuals with acute or convalescent COVID-19. The authors report that the alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients. In contrast, T cells from convalescent patients displayed long-term alterations with persistence of a cytotoxic programme evident in CD8+ T cells as well as elevated production of type-1 cytokines and IL-17. B cells from patients with acute COVID-19 displayed an IL-6/ IL-10 cytokine imbalance in response to toll-like receptor activation, skewed towards a pro-inflammatory phenotype. Whereas the frequency of IL-10+ B cells was restored in a subset of convalescent patients, IL-6 production remained elevated. This data is the first to define long-term alterations in the lymphocyte compartment of previously hospitalized COVID-19 patients, at up to 19 weeks of convalescence, and identify 3 subgroups of convalescent patients based on distinct lymphocyte phenotypes. The authors propose that alterations in B and T cell function following hospitalisation with COVID-19 could impact long-term immunity and contribute to some persistent symptoms observed in convalescent COVID-19 patients.
Impact of COVID-19 in the attendance of blood donors and production on a Brazilian Blood Centres	Silva-Malta,  M,  Rodrigues, et al	Transfus Med	Healthcare Response | Réponse des soins de santé	The objective was to determine the impact of the COVID-19 pandemic on the blood donor's attendance and production of blood components in Fundação Hemominas, a Brazilian public institution. A cross-sectional study was conducted from January to June 2020. Data collected were compared to a historical series from 2016 to 2019. The study showed a reduction in the attendance of blood donors, whole blood collections and blood component production from March 2020, when the first case of COVID-19 was notified in Minas Gerais, Brazil. The results evidenced that Hemominas Blood Centres were affected in a very distinct way by the pandemic with a general mean reduction around 17% in attendance of blood donors and in production of blood components in the period of March to June. On the other hand, the return of blood donors rate increased. The reduction in blood donation during the pandemic period was significant, despite the measures adopted.
Anger and confrontation during the COVID-19 pandemic: a national cross-sectional survey in the UK	Smith,  LE,  Duffy, et al	J R Soc Med	Public Health response| Interventions de santé publique	The aim of the study was to investigate factors associated with anger or confronting others due to COVID-19. An online cross-sectional survey was conducted iwht 2237 participants living in the UK aged 16-75 years. Data were collected between July 17-20, 2020. Most participants reported having had arguments, feeling angry or fallen out with others because of COVID-19 (56%, n = 1255). Twenty-two percent (n = 500) of participants reported that they had confronted or reported someone. Fourteen percent (n = 304) of participants reported that they had been confronted or reported by someone. Confronting someone, having been confronted and feeling angry or having had arguments were strongly associated with each other. Anger and confrontation were associated with younger age, greater likelihood of experiencing significant financial difficulties due to the pandemic, greater perceived risk of COVID-19 and getting information about COVID-19 from social media.
Designing a Network Proximity-Based Drug Repurposing Strategy for COVID-19	Stolfi,  P,  Manni, et al	Frontiers in Cell and Developmental Biology	Coronavirology| Coronavirologie Therapeutics| Thérapeutique	A comprehensive molecular framework of the disease is needed to better understand its pathological mechanisms, and to design successful treatments able to slow down and stop the impressive pace of the outbreak and harsh clinical symptomatology, possibly via the use of readily available, off-the-shelf drugs. This work engages in providing a wider picture of the human molecular landscape of the SARS-CoV-2 infection via a network medicine approach as the ground for a drug repurposing strategy. The normalization and the aggregation of the different scores allowed to define a preliminary, restricted list of genes candidates as pharmacological targets for drug repurposing, with the aim of contrasting different phases of the virus infection and viral replication cycle.
[Needs of long-term nursing in the COVID-19 pandemic]	Stolle,  C,  Schmidt, et al	Z Gerontol Geriatr	Healthcare Response | Réponse des soins de santé	In a nationwide cross-sectional study the situation and needs of inpatient and outpatient long-term care facilities during the SARS-CoV‑2 pandemic were assessed and analyzed using an online survey. Participants from 531 institutions postulated the need for uniform recommendations for action on SARS-CoV‑2, adequate and affordable protective and hygiene materials, serial tests in the institutions, well-founded advice on the implementation of interventions, a specific pandemic plan and supporting public relations work by the media. This calls for higher nursing remuneration, better staffing levels and greater appreciation of the nursing profession.
33072200; Mental Health Disorders During the COVID-19 Outbreak in Cyprus	Stylianou,  N,  Samouti, et al	Journal of medicine and life	Public Health response| Interventions de santé publique	We aimed to assess the mental health burden of the Cypriot population during the outbreak and to explore the potential influence factors. Using a web-based cross-sectional survey, we collected data from 216 volunteers regarding demographic data, COVID-19-related knowledge, generalized anxiety disorder (GAD), and major depressive symptoms. The overall prevalence of GAD and major depressive symptoms of the public were 13.89% and 8.33%, respectively. No demographic had shown any statistical significance with GAD. The younger age group of the study showed a statistically significant association with major depressive symptoms when compared to the adult population in both univariate and multivariable analyses. Our study identified a mental health burden of the Cypriot population, especially the younger age groups.
A survey of preparedness against COVID-19 in hospitals in Tokyo, Japan with healthcare personnel with COVID-19 and in-facility transmission	Tagashira,  Y,  Takamatsu, et al	Infect Control Hosp Epidemiol	Transmission Healthcare Response | Réponse des soins de santé	A questionnaire was distributed to hospitals in Tokyo (N=38) asking about their preparedness against, and in-facility transmission of, COVID-19. As of May 31, 2020, 284 HCP contracted COVID-19, and in-facility COVID-19 transmission occurred at 13 hospitals, negatively impacting hospital functions and patient care.
An artificial intelligence nanopore platform for SARS-CoV-2 virus detection	Taniguchi,  Masateru,  Minami, et al	Research Square prepub	Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes	We report a method for detecting novel coronaviruses with high sensitivity using artificial intelligent nanopores utilizing a simple procedure that does not require RNA extraction. Artificial intelligent nanopore platform consists of machine learning software on the servers, portable high-speed and high-precision current measuring instrument, and scalable, cost-effective semiconducting nanopore modules. Here we show that the artificial intelligent nanopores are successful in accurate identification of four types of coronaviruses, HCoV-229E, SARS-CoV, MERS-CoV, and SARS-CoV-2, which are usually extremely difficult to detect. The positive/negative diagnostics of the new coronavirus is achieved with a sensitivity of 95 % and specificity of 92 % with a 5-minute diagnosis. The platform enables high throughput diagnostics with low false negatives for the novel coronavirus.
33054122; Real-time national survey of COVID-19 in hemoglobinopathy and rare inherited anemia patients	Telfer,  P,  De la Fuente, et al	Haematologica	Healthcare Response | Réponse des soins de santé	In order to evaluate the impact of these measures and inform guidance on the clinical management of COVID-19 and public health policy, a real-time survey of confirmed and suspected cases of COVID-19 in hemoglobinopathy and rare inherited anemia patients was initiated on behalf of the NHP and National Health Service (NHS) England Clinical Reference Group for Hemoglobinopathies. Data were submitted weekly by the 14 Hemoglobinopathy Coordinating Centers (HCC) in England, providing national coverage. Our survey raises concern that an unintended consequence of shielding could be the delayed presentation of life-threatening complications in hemoglobinopathy and rare anemia patients.
Clinical features of patients undergoing hemodialysis with COVID-19	Tian,  M,  Li, et al	Semin Dial	Epidemiology| Épidémiologie Clinical data| Données cliniques	Hemodialysis patients are susceptible to coronavirus disease 2019 (COVID-19). The aim of this study was to describe the epidemiological, clinical characteristics, and mortality-related risk factors for those who undergoing hemodialysis with COVID-19. We conducted a retrospective study. A total of 49 hemodialysis patients with COVID-19 (Group 1) and 74 uninfected patients (Group 2) were included. For patients in Group 1, we found the median age was 62 years (36-89 years), 59.3% were male, and the median dialysis vintage was 26 months. Twenty-eight patients (57%) had three or more comorbidities and two patients (4%) died. The most common symptoms were fever (32.7%) and dry cough (46.9%), while nine patients (18.4%) were asymptomatic. Blood routine tests indicated lymphocytopenia, the proportion of lymphocyte subsets was generally reduced, and chest CT scans showed ground-glass opacity (45.8%) and patchy shadowing (35.4%). However, these findings were not specific to hemodialysis patients with COVID-19, and similar manifestations could be found in patients without SARS-CoV-2 infection. In conclusion, for hemodialysis patients with COVID-19, lymphocytopenia and ground-glass opacities or patchy opacities were common but not specific to them, early active treatment and interventions against nosocomial infection can significantly reduce the mortality and the risk of SARS-CoV-2 infection.
Reinfection of COVID-19 after 3 months with a distinct and more aggressive clinical presentation: case report	Torres,  DA,  Ribeiro, et al	J Med Virol	Clinical data| Données cliniques	We report the case of a Brazilian doctor who, after presenting a mild clinical episode of COVID-19 with molecular confirmation by RT-PCR in March 2020, appeared with a new acute infection by SARS-CoV-2 three months later. In middle of June, she had significant and very specific symptoms of COVID-19 with tomographic and serological confirmation of reinfection. There is a strong probability that these two episodes of infection were caused by different viral strains and that each genetic variation is related to specific clinical manifestations. We observed that, in addition to the different symptoms presented in the reinfections' episode, there was a more intense organic inflammatory response to the virus, with clinical repercussion. This clinical case should be an alert regarding the maintenance of individual protection among health cares, even in individuals who have already had COVID-19, since there is still no guarantee of prolonged immunity.
Gamma-irradiated SARS-CoV-2 vaccine candidate, OZG-38.61.3, confers protection from SARS-CoV-2 challenge in human ACEII-transgenic mice	Turan,  Raife Dilek,  Tastan, et al	bioRxiv	Vaccine Research| Recherche sur les vaccins Animal model | Modèle animal	We optimized an inactivated virus vaccine which includes the gamma irradiation process for the inactivation as an alternative to classical chemical inactivation methods so that there is no extra purification required. Also, we applied the vaccine candidate (OZG-38.61.3) using the intradermal route in mice which decreased the requirement of a higher concentration of inactivated virus for proper immunization unlike most of the classical inactivated vaccine treatments. Thus, the novelty of our vaccine candidate (OZG-38.61.3) is a non-adjuvant added, gamma-irradiated, and intradermally applied inactive viral vaccine. We first determined the efficiency and safety dose (either 1013 or 1014 viral copy per dose) of the OZG-38.61.3 in Balb/c mice. Next, to test the immunogenicity and protective efficacy of the OZG-38.61.3, we immunized human ACE2-encoding transgenic mice and infected them with a dose of infective SARS-CoV-2 virus for the challenge test. We showed that the vaccinated mice showed lowered SARS-CoV-2 viral copy number in oropharyngeal specimens along with humoral and cellular immune responses against the SARS-CoV-2, including the neutralizing antibodies similar to those shown in Balb/c mice without substantial toxicity. This study encouraged us towards a new promising strategy for inactivated vaccine development (OZG-38.61.3) and the Phase 1 clinical trial for the COVID-19 pandemic.
33070481; The Challenge of Treating Kidney Transplant Recipients Infected with COVID-19: Report of the First Cases in Israel	Tzukert,  K,  Abel, et al	The Israel Medical Association journal : IMAJ	Clinical data| Données cliniques	We describe treatment and outcome of the first two kidney transplant recipients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Israel.
COVID-19 Associated Acute Necrotizing Encephalopathy in a Hospitalized Cohort in Oregon	Vanni,  Holly,  Jou, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques	Aim to study COVID-19 related acute necrotizing encephalopathy. Observational study of COVID-19 patients admitted to two hospitals of a large metropolitan health maintenance organization serving over 600,000 members using retrospective electronic and radiographic medical record evaluation across 4 months (March – June of 2020) after multiple cases of acute necrotizing encephalopathy were diagnosed.  During this time frame 216 patients were diagnosed with COVID-19, 106 (49%) required hospitalization, 21 (20%) required admission to the intensive care unit (ICU) and 18 (17%) required intubation. Of the 18, 4 (22%) had clinicoradiologic evidence of acute necrotizing encephalopathy (ANE) diagnosed, two with associated areas of hemorrhage.  We identified a high percentage of COVID-19 patients with clinicoradiologic evidence of acute necrotizing encephalopathy in our cohort. To our knowledge, ANE has not been reported in patients with SARS or MERS.
Socioeconomic determinants of COVID-19 in Asian countries: An empirical analysis	Varkey,  RS,  Joy, et al	Journal of Public Affairs	Epidemiology| Épidémiologie	The paper is an attempt to empirically examine the socioeconomic determinants of the occurrence of COVID in Asian countries considering the data as of June 18, 2020, for 42 Asian countries. The findings of the study show a positive significant association of per capita gross national income and net migration with the incidence of total COVID-19 cases and daily new cases. The size of net migration emerged to be a potential factor and positive in determining the total and new cases of COVID. Social capital as measured by voters' turnout ratio (VTR) in order to indicate the people's participation is found to be significant and negative for daily new cases per million population. People's participation has played a very important role in checking the incidence of COVID cases and its spread. In alternate models, countries having high incidence of poverty are also having higher cases of COVID. Though the countries having higher percentage of aged populations are more prone to be affected by the spread of virus, but the sign of the coefficient of this variable for Asian country is not in the expected line. Previous year health expenditure and diabetic prevalence rate are not significant in the analysis.
33007154; Pigs are not susceptible to SARS-CoV-2 infection but are a model for viral immunogenicity studies	Vergara-Alert,  J,  Rodon, et al	Transboundary and Emerging Diseases	Immunology | Immunologie Animal model | Modèle animal	Conventional piglets were inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through different routes, including intranasal, intratracheal, intramuscular and intravenous ones. Although piglets were not susceptible to SARS-CoV-2 and lacked lesions or viral RNA in tissues/swabs, seroconversion was observed in pigs inoculated parenterally
PMC7592145; Effects of the COVID-19 lockdown on criteria air pollutants in the city of Daegu, the epicenter of South Korea's outbreak	Vuong,  QT,  Thang, et al	Environ Sci Pollut Res Int	Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique	This study investigates the association of meteorology and the new daily COVID-19 confirmed cases and the effects of the city lockdown on the variation in criteria air pollutants (CAPs) in Daegu. Ambient temperature and relative humidity were negatively correlated to the new daily cases and played an important role in the spread of COVID-19. Wind speed could enhance the virus transmission through the inhalation of aerosols and/or droplets and contact with fomites. The lockdown has directly decreased the concentrations of CAPs. In particular, reductions of 3.75% (PM(10)), 30.9% (PM(2.5)), 36.7% (NO(2)), 43.7% (CO), and 21.3% (SO(2)) between the period before and during the outbreak were observed over the entire city. An increase in O(3) (71.1%) was affected by natural processes and photochemical formation other than the lockdown effects. The three central districts were the areas most affected by the virus and showed the highest reductions in CAPs (except for O(3)) during the outbreak. Apart from the influence of the lockdown, the decreasing trend in CAPs may be a result of the actions taken by the government to mitigate air pollutants nationwide since 2019.
Robust neutralizing antibodies to SARS-CoV-2 infection persist for months	Wajnberg,  A,  Amanat, et al	Science	Clinical data| Données cliniques Immunology | Immunologie	Here we report that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust IgG antibody responses against the viral spike protein, based on a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City. We also show that titers are relatively stable for at least a period approximating 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2. Our data suggests that more than 90% of seroconverters make detectible neutralizing antibody responses. These titers remain relatively stable for several months after infection.
The unexpected spectacular 2020 October COVID-19 boost in European countries correlated with the latitude, but not with the temperature	Walrand,  Stephan	medRxiv	Epidemiology| Épidémiologie Surveillance	The present study shows no correlation between the country COVID-19 boost date and its 2 weeks preceding temperature, but shows an impressive correlation with the country latitude. As the daily UV insolation earlier decreases in autumn for higher latitudes, this is an additional observation supporting the impact of low vitamin blood D level on the respiratory impairment in COVID-19 disease.
Optimal COVID-19 quarantine and testing strategies	Wells,  ChadR,  Townsend, et al	medRxiv	Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de santé publique	We developed a mathematical model to quantify the probability of post-quarantine transmission that varied across a range of possible quarantine durations, timings of molecular testing, and estimated incubation periods. We found that a 13-day quarantine with testing on entry, a nine-day quarantine with testing on exit, and an eight-day quarantine with testing on both entry and exit each provide equivalent or lower probability of post-quarantine transmission compared to a 14-day quarantine with no testing. We found that testing on exit from quarantine is more effective in reducing probability of post-quarantine transmission than testing upon entry. When conducting a single test, testing on exit was most effective for quarantines of six days or shorter, while testing on day six or seven is optimal for longer quarantines. Optimal timing of testing during quarantine will reduce the probability of post-quarantine transmission, as false-positive results become less likely, enabling case isolation. Based on 4,040 SARS CoV-2 RT-PCR tests, an exit test 96 hours after the start of quarantine for an offshore oil rig population was demonstrated to identify all known asymptomatic cases that previously tested negative at entry, and-moreover-successfully prevented an expected seven or more offshore transmission events, each a serious concern for initiating rapid spread and a disabling outbreak in the close quarters of an offshore rig. This successful outcome highlights the importance of context-specific guidelines for the duration of quarantine and timing of testing that can minimize economic impacts, disruptions to operational integrity, and COVID-related public health risks.
PMC7592188; [Risk stratification of emergencies during the COVID-19 pandemic within the emergency department]	Wieckenberg,  M,  Meier, et al	Med Klin Intensivmed Notfmed	Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé	In this study a model of risk stratification for suspected SARS-CoV‑2 and COVID-19 cases was developed on the basis of epidemiologic criteria of the Robert-Koch Institute including five risk categories (RC). The model was implemented in a hospital of basic and regular care level. By combination of risk categories with specific isolation, hygienic and personal protection procedures all areas of the ED were restructured. In a retrospective study all inpatient cases (n = 491) were re-evaluated during a 4-week interval (26 March-26 April 2020).  In the study population 25 SARS-CoV‑2 positive cases (5.2%) were identified. These cases were categorized according to the risk stratification model as follows: RC I-confirmed SARS-CoV‑2 infection 36% (n = 9), RC II-reasonable suspected cases 32% (n = 8), RC III-differential diagnostic cases 12% (n = 3), RC IV-low probability 8% (n = 2) and RC V-no evidence 12% (n = 3). No viral transmission was detected during the whole period within medical staff and patients of the ED. Introduction of COVID-19 risk categories within the ED permits central control of important hygienic processes with respect to SARS-CoV‑2 infection probability.
Changes in risk perception and self-reported protective behaviour during the first week of the COVID-19 pandemic in the United States: COVID-19 risk perception and behavior	Wise,  T,  Zbozinek, et al	Royal Society Open Science	Public Health response| Interventions de santé publique	We investigated risk perception and self-reported engagement in protective behaviours in 1591 United States-based individuals cross-sectionally and longitudinally over the first week of the pandemic. Subjects demonstrated growing awareness of risk and reported engaging in protective behaviours with increasing frequency but underestimated their risk of infection relative to the average person in the country. Social distancing and hand washing were most strongly predicted by the perceived probability of personally being infected. However, a subgroup of individuals perceived low risk and did not engage in these behaviours. Our results highlight the importance of risk perception in early interventions during large-scale pandemics.
Identification of SARS-CoV-2 entry inhibitors among already approved drugs	Yang,  L,  Pei, et al	Acta Pharmacol Sin	Therapeutics| Thérapeutique	An approved drug library of 1800 small molecular drugs was screened for SARS2 entry inhibitors. 7 of these drugs (clemastine, amiodarone, trimeprazine, bosutinib, toremifene, flupenthixol, and azelastine) significantly inhibited SARS2 replication in Vero E6 cells.
A Machine Learning Model to Predict Death Outcome in Severe COVID-19 Patients	Yang,  Qiao,  Li, et al	Research Square prepub	Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	A total of 2,169 adult COVID-19 patients were enrolled from Wuhan, China between February 10th and April 15th, 2020. Difference analyses of medical records were performed between severe and non-severe groups as well as between survivors and non-survivors. A machine learning model was developed to predict death outcome in severe patients. The decision tree classifier included three biomarkers, neutrophil-to-lymphocyte ratio, C-reactive protein and lactic dehydrogenase.
Warning 'Don't spread' versus 'Don't be a spreader' to prevent the COVID-19 pandemic: Preventing messages in COVID-19 pandemic	Yonemitsu,  F,  Ikeda, et al	Royal Society Open Science	Public Health response| Interventions de santé publique	The present study investigated whether reminders that highlight self-identity would be effective in changing intention and behaviour related to the COVID-19 outbreak. Those who read reminders highlighting self-identity (Don't be a spreader) showed no significant improvement in infection-prevention behaviours as compared to those who read 'Don't spread'. Participants marked their responses to IP intentions and actual behaviours each week based on the Japanese Ministry of Health, Labour and Welfare guidelines.
A case of urgent colonoscopic hemostasis of a cecal hemorrhagic ulceration in a patient receiving heparin for COVID-19 coagulopathy	Yoshida,  N,  Hirose, et al	JGH Open	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	Here, we present a case of colonoscopic hemostasis of a cecal hemorrhagic ulceration in a patient on heparin for COVID-19 coagulopathy. We also share various management methods for the prevention of COVID-19 contamination.
Molecular docking reveals the potential of: Cleome amblyocarpa isolated compounds to inhibit COVID-19 virus main protease	Zaki,  AA,  Al-Karmalawy, et al	New Journal of Chemistry	Therapeutics| Thérapeutique	Nine flavonoids and one saponin were isolated from the aerial parts of Cleome amblyocarpa. Molecular docking of isolated compounds on COVID-19 virus main protease showed variable binding affinities with scores ranging from -8.63 to -6.08 compared to N3 inhibitor.
33061829; Distinguishable Immunologic Characteristics of COVID-19 Patients with Comorbid Type 2 Diabetes Compared with Nondiabetic Individuals	Zhao,  R,  Sun, et al	Mediators of inflammation	Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie	Here, we make efforts to examine whether comorbidity with type 2 diabetes (T2D) affects the immunological response in COVID-19 patients. The COVID-19 patients comorbid with T2D demonstrated distinguishable immunological parameters which may represent risk factors of COVID-19 severity.
A COVID-19 descriptive study of life after lockdown in Wuhan, China: Descriptive study of life after lockdown	Zhou,  T,  Nguyen, et al	Royal Society Open Science	Public Health response| Interventions de santé publique	The aim of this research was to track longitudinal changes in motivation for self-isolating, life-structured, indicators of well-being and mental health after lockdown was lifted in Wuhan, the epicentre of the COVID-19 pandemic. Generally, our study found that: (i) a majority of people still continue to value self-isolation after lockdown was lifted; (ii) by the end of lockdown, people perceived gradual return to normality and restored structure of everyday life; (iii) the psychological well-being slightly improved after lockdown was lifted; (iv) people who used problem solving and help-seeking as coping strategies during lockdown had better well-being and mental health by the end of the lockdown; (v) those who experienced more disruptions in daily life during lockdown would display more indicators of psychological ill-being by the end of the lockdown.
33062712; Clinical Features of COVID-19 Patients with Diabetes and Secondary Hyperglycemia	Zhou,  W,  Ye, et al	Journal of diabetes research	Epidemiology| Épidémiologie Clinical data| Données cliniques	This study aims to investigate the clinical characteristics of COVID-19 patients with diabetes and secondary hyperglycemia. Severity of COVID-19 was defined based on the diagnostic and treatment guideline for SARS-CoV-2 issued by Chinese National Health Committee. Diabetes is a risk factor for influence of the progression and prognosis of COVID-19 due to ongoing inflammation and impaired immune response.
Intravenous thrombolysis for acute ischaemic stroke during COVID-19 pandemic in Wuhan, China: a multicentre, retrospective cohort study	Zhou,  Y,  Hong, et al	J Neurol Neurosurg Psychiatry	Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé	Here, we report intravenous thrombolytic therapy for patients with acute ischaemic stroke (AIS) at four stroke centres in the epicentre of Wuhan, Hubei during the epidemic, and compare the treatment provided during the same period in 2019. Ultraearly intravenous thrombolysis for patients with acute ischaemic stroke (AIS) is highly time-sensitive. The time to the administration of intravenous tPA was nearly doubled duing the epidemic. Such delay could be due to: shortage of stroke team members, slow down of evaluations, practising precautionary procedures and obeying the mandatory traffic restriction.
Correlates of Health-Protective Behavior During the Initial Days of the COVID-19 Outbreak in Norway	Zickfeld,  JH,  Schubert, et al	Frontiers in Psychology	Public Health response| Interventions de santé publique	We investigated psychological and demographic factors predicting the adoption and engagement in health-protective behavior. Engagement in health protective behaviour was associated with increased media exposure, perceiving measures as effective and perceiving the outbreak as serious. Contrary to previous studies, we found no or only small positive predictions by confidence in authorities, knowledge about the outbreak, and perceived individual risk.
An Optimal Control Approach to Learning in SIDARTHE Epidemic model	Zugarini,  Andrea,  Meloni, et al	arXiv	Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie	In this paper we propose a general approach for learning time-variant parameters of dynamic compartmental models from epidemic data. Results indicate that the model provides reliable forecasts of the epidemic evolution in Italy and France
PMC7592143; Overview of the possible role of vitamin C in management of COVID-19	Abobaker,  A,  Alzwi, et al	Pharmacol Rep	Review Literature| Revue de littérature
COVID-19: Evidence review of an evolving pandemic	Acuña,  MP,  Arancibia, et al	Revista Chilena de Anestesia	Review Literature| Revue de littérature
National Responses for Persons Deprived of Liberty during the COVID-19 Pandemic in the Philippines	Cahapay,  MB	Victims and Offenders	Review Literature| Revue de littérature
Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease	Cardozo,  T,  Veazey, et al	Int J Clin Pract	Review Literature| Revue de littérature
Evidence-Based Management of the Critically Ill Adult With SARS-CoV-2 Infection	Chivukula,  RR,  Maley, et al	J Intensive Care Med	Review Literature| Revue de littérature
Mechanisms and potential therapeutic targets of hyperinflammatory responses in SARS-CoV2	Chukwuma,  IF,  Apeh, et al	Acta Virol	Review Literature| Revue de littérature
Recurrence of SARS-CoV-2 viral RNA in recovered COVID-19 patients: a narrative review	Dao,  TL,  Hoang, et al	Eur J Clin Microbiol Infect Dis	Review Literature| Revue de littérature
Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients	DeKosky,  ST,  Kochanek, et al	J Neurotrauma	Review Literature| Revue de littérature
33070543; SARS-CoV-2 infection in patients with diabetes mellitus and hypertension: a systematic review	Deravi,  N,  Fathi, et al	Reviews in cardiovascular medicine	Review Literature| Revue de littérature	SR: searched the electronic databases of Pubmed, Google Scholar, Excerpta Media Database (EMBASE), Web of Science and ResearchGate from January 1st 2003 until March 30th 2020. Diabetes may downregulate the humoral and innate immune systems through reducing the functions of neutrophils and T cells, which may result in secondary infections.
The Prevalence of Gastrointestinal Symptoms, Abnormal Liver Function, Digestive System Disease and Liver Disease in COVID-19 Infection: A Systematic Review and Meta-Analysis	Dong,  ZY,  Xiang, et al	J Clin Gastroenterol	Review Literature| Revue de littérature	SR-MA: searched PubMed, Ovid Embase, Medline, and 2 Chinese databases. The most significant GI symptoms were anorexia and diarrhea. The most significant abnormal liver function was increased ALT. Severe patients were more likely to have GI symptoms and abnormal liver function.
Cutaneous lymphomas and COVID-19: What is known so far?	Elmasry,  MF,  Youssef, et al	Dermatol Ther	Review Literature| Revue de littérature
33058134; The Cutaneous Manifestations of COVID-19: A Review of Emerging Literature	Enitan,  AO,  Olasode, et al	West African journal of medicine	Review Literature| Revue de littérature
COVID-19, varying genetic resistance to viral disease, and immune tolerance checkpoints	Goodnow,  CC	Immunol Cell Biol	Review Literature| Revue de littérature
33070542; Current targets and drug candidates for prevention and treatment of SARS-CoV-2 (COVID-19) infection	Goyal,  RK,  Majeed, et al	Reviews in cardiovascular medicine	Review Literature| Revue de littérature
Guillain-Barré syndrome associated with SARS-CoV-2 infection: a systematic review and individual participant data meta-analysis	Hasan,  I,  Saif-Ur-Rahman, et al	J Peripher Nerv Syst	Review Literature| Revue de littérature	SR:  searched the PubMed (Medline), Web of Science and Cochrane databases for articles published between January 1(st) and August 5(th) 2020. SARS-CoV-2-associated GBS mostly resembles the classical presentations of GBS that respond to standard treatments. Extensive surveillance is required in low- and lower-middle-income countries to identify and report similar cases/series. Further large-scale case-control studies are warranted to strengthen the current evidence.
33070500; The Evolving Policy Debate on Border Closure in Korea	Kang,  S,  Moon, et al	Journal of preventive medicine and public health = Yebang Uihakhoe chi	Review Literature| Revue de littérature
BCG vaccination provides protection against COVID 19: A Systematic review and meta-analysis	Khera,  Daisy,  Chugh, et al	Research Square prepub	Review Literature| Revue de littérature	SR-MA:  PubMed, Cochrane database and clinicaltrials.gov were searched. The evidence of BCG vaccination for protection against COVID-19 can’t be ruled out as evidence from many studies support the hypothesis but the evidence of well conducted RCTs and observational studies can strengthen the evidence.
Virtual adaptation of traditional healthcare quality improvement training in response to COVID-19: a rapid narrative review	Khurshid,  Z,  De Brún, et al	Hum Resour Health	Review Literature| Revue de littérature
A Comprehensive Review of Neurologic Manifestations of COVID-19 and Management of Pre-existing Neurologic Disorders in Children	Kim,  Y,  Walser, et al	J Child Neurol	Review Literature| Revue de littérature
33070544; Cardiovascular system and COVID-19: manifestations and therapeutics	Mahenthiran,  AK,  Mahenthiran, et al	Reviews in cardiovascular medicine	Review Literature| Revue de littérature
Molecular diversity of coronavirus host cell entry receptors	Millet,  JK,  Jaimes, et al	FEMS Microbiol Rev	Review Literature| Revue de littérature
Prevalence and outcomes of co-infection and super-infection with SARS-CoV-2 and other pathogens: A Systematic Review and Meta-analysis	Musuuza,  Jackson Ssentalo,  Watson, et al	medRxiv	Review Literature| Revue de littérature	SR-MA:  searched literature databases for studies published from October 1, 2019, through June 11, 2020.Conclusions: Our study showed that as many as 14% of patients with COVID-19 have super-infections and 12% have co-infections. Poor outcomes were associated with super-infections. Our findings have implications for diagnostic testing and therapeutics, particularly in the upcoming respiratory virus season in the Northern Hemisphere.
Assessing the Effects of COVID-19 in Prisons in the Northern Triangle of Central America	Pitts,  WJ,  Inkpen, et al	Victims and Offenders	Review Literature| Revue de littérature
Literature review on Virus and Host Response Proteins in COVID-19: Pathobiology, Management, Diagnosis and Treatment	Rajaraman,  R,  Yedida, et al	Acta Virol	Review Literature| Revue de littérature
Characteristics of invasive mechanical ventilation in COVID-19 for non-specialist medical	Rozas,  BA,  Jocelyn Vargas Urra, et al	Revista Chilena de Anestesia	Review Literature| Revue de littérature
Biodiversity and epidemic potential of Chiropteran coronaviruses (Nidovirales: Coronaviridae)	Shestopalov,  AM,  Kononova, et al	South of Russia: Ecology, Development	Review Literature| Revue de littérature
Targeting Crucial Host Factors of SARS-CoV-2	Tharappel,  AM,  Samrat, et al	ACS Infect Dis	Review Literature| Revue de littérature
33070547; Critical complications of COVID-19: A descriptive meta-analysis study	Vakili,  K,  Fathi, et al	Reviews in cardiovascular medicine	Review Literature| Revue de littérature	MA: All relevant studies on the clinical complications of COVID-19 have been identified by searching two web databases (i.e., PubMed and Scopus).  In this study, we assessed the prevalence of the main clinical complications of COVID-19, and found that following respiratory complications, cardiac and renal complications are the most common clinical complications of COVID-19.
Outcomes of patients with hematologic malignancies and COVID-19: A systematic review and meta-analysis of 3377 patients	Vijenthira,  A,  Gong, et al	Blood	Review Literature| Revue de littérature	SR-MA: searched Pubmed and EMBASE up to August 20, 2020.  Patients aged >60 years had a significantly higher risk of death than patients 60 years have significantly higher mortality, and pediatric patients appear to be relatively spared. Recent cancer treatment does not appear to significantly increase the risk of death.
Coronavirus biology and replication: implications for SARS-CoV-2	V'Kovski,  P,  Kratzel, et al	Nat Rev Microbiol	Review Literature| Revue de littérature
The Response to the COVID19 Crisis by the Pennsylvania Department of Corrections	Wetzel,  JE,  Davis, et al	Victims and Offenders	Review Literature| Revue de littérature
Capsule endoscopy - Recent developments and future directions	Zammit Chetcuti,  S,  Sidhu, et al	Expert Rev Gastroenterol Hepatol	Review Literature| Revue de littérature
33070539; Vitamin D deficiency in association with endothelial dysfunction: Implications for patients with COVID-19	Zhang,  J,  McCullough, et al	Reviews in cardiovascular medicine	Review Literature| Revue de littérature
33070537; Endothelial dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy	Zhang,  J,  Tecson, et al	Reviews in cardiovascular medicine	Review Literature| Revue de littérature
SARS-CoV-2 and Health Care Worker Protection in Low-Risk Settings: a Review of Modes of Transmission and a Novel Airborne Model Involving Inhalable Particles	Zhang,  XS,  Duchaine, et al	Clin Microbiol Rev	Review Literature| Revue de littérature
33070540; Usefulness of machine learning in COVID-19 for the detection and prognosis of cardiovascular complications	Zimmerman,  A,  Kalra, et al	Reviews in cardiovascular medicine	Review Literature| Revue de littérature
ACE2, COVID-19 Infection, Inflammation, and Coagulopathy: Missing Pieces in the Puzzle	Abassi,  Z,  Higazi, et al	Frontiers in Physiology	Commentary/Editorial| Commentaire/Éditorial
Mishandling of the recent COVID-19 pandemics in the world	Adil,  MI	Medical Forum Monthly	Commentary/Editorial| Commentaire/Éditorial
Is amiloride a promising cardiovascular medication to persist in the COVID-19 crisis?	Adil,  MS,  Narayanan, et al	Drug Discov Ther	Commentary/Editorial| Commentaire/Éditorial
32876489; Exergaming as a Supportive Tool for Home-Based Rehabilitation in the COVID-19 Pandemic Era	Ambrosino,  P,  Fuschillo, et al	Games for health journal	Commentary/Editorial| Commentaire/Éditorial
Treating multidrug-resistant psoriasis with brodalumab, apremilast, methotrexate and prednisone combination therapy in the COVID-19 pandemic	Armesto,  S,  González Vela, et al	Dermatol Ther	Commentary/Editorial| Commentaire/Éditorial
Pandemic India: Coronavirus and the uses of history	Arnold,  D	Journal of Asian Studies	Commentary/Editorial| Commentaire/Éditorial
Evidence for increased circulating procoagulant phospholipids in patients with COVID-19 pneumonia and their prognostic role	Assimakopoulos,  SF,  Emmanuil, et al	Clin Chem Lab Med	Commentary/Editorial| Commentaire/Éditorial
Will covid-19 cause a war? Understanding the case of the U.S. And China	Bapat,  N	Peace Economics, Peace Science and Public Policy	Commentary/Editorial| Commentaire/Éditorial
Introduction: Ethnography in and of the age of Covid-19	Bassetti,  C,  Fine, et al	Etnografia e Ricerca Qualitativa	Commentary/Editorial| Commentaire/Éditorial
The allergist/immunologist, the Janus gatekeeper of inflammation, COVID-19 and beyond	Bellanti,  JA,  Settipane, et al	Allergy Asthma Proc	Commentary/Editorial| Commentaire/Éditorial
Displacement ventilation: A viable ventilation strategy for makeshift hospitals and public buildings to contain COVID-19 and other airborne diseases: Ventilation strategy for COVID-19	Bhagat,  RK,  Linden, et al	Royal Society Open Science	Commentary/Editorial| Commentaire/Éditorial
Towards consensus on correct interpretation of protein binding in plasma and other biological matrices for COVID-19 therapeutic development	Boffito,  M,  Back, et al	Clin Pharmacol Ther	Commentary/Editorial| Commentaire/Éditorial
Why do SARS-COV vaccines not exist? The pharma scientific intelligence and business model must be revisited!	Boudjelal,  M,  Nehdi, et al	Expert Opin Drug Discov	Commentary/Editorial| Commentaire/Éditorial
Viral reflections: Placing China in global health histories	Brazelton,  MA	Journal of Asian Studies	Commentary/Editorial| Commentaire/Éditorial
Developing new models of care at speed: learning from healthcare redesign for children with COVID-related multisystem inflammation	Cheung,  CR,  Finnemore, et al	Arch Dis Child	Commentary/Editorial| Commentaire/Éditorial
Post-COVID-19 challenges in the indian IT industry	Chinchwadkar,  R,  Kathuria, et al	Economic and Political Weekly	Commentary/Editorial| Commentaire/Éditorial
From crisis to opportunity?: innovations in Australian social work field education during the COVID-19 global pandemic	Clarke,  J,  Morley, et al	Social Work Education	Commentary/Editorial| Commentaire/Éditorial
A Case Study of the Westchester County New York’s Jail Response to COVID-19: Controlling COVID while Balancing Service Needs for the Incarcerated-A National Model for Jails	Collica-Cox,  K,  Molina, et al	Victims and Offenders	Commentary/Editorial| Commentaire/Éditorial
COVID-19 pandemic: A paradigm shift in the West?	Conti,  M,  Bellucci, et al	Revista Chilena de Anestesia	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and the water sector: understanding impact, preparedness and resilience in the UK through a sector-wide survey	Cotterill,  S,  Bunney, et al	Water and Environment Journal	Commentary/Editorial| Commentaire/Éditorial
PMC7462829; Should air pollution health effects assumptions be tested? Fine particulate matter and COVID-19 mortality as an example	Cox,  LA,  J, et al	Glob Epidemiol	Commentary/Editorial| Commentaire/Éditorial
COVID-19: Reflections from Entomologists Who Rose to the Occasion	Coyle,  D,  Brosius, et al	American Entomologist	Commentary/Editorial| Commentaire/Éditorial
Rapid deployment of SARS-CoV-2 testing: The CLIAHUB	Crawford,  ED,  Acosta, et al	PLoS Pathog	Commentary/Editorial| Commentaire/Éditorial
COVID-19 at Biblioteca Utopía, Buenos Aires, Argentina	D'Amico,  PB	International Information and Library Review	Commentary/Editorial| Commentaire/Éditorial
Caution warranted for low-dose radiation therapy for Covid-19	Das,  IJ,  Kalapurakal, et al	Br J Radiol	Commentary/Editorial| Commentaire/Éditorial
Impact of the SARS-CoV-2 (COVID-19) pandemic in the field of reproductive medicine and its treatments	de Bilbao,  GM	Gaceta Medica de Bilbao	Commentary/Editorial| Commentaire/Éditorial
COVID-19. Update in full pandemic	de Bilbao,  GM	Gaceta Medica de Bilbao	Commentary/Editorial| Commentaire/Éditorial
Contributions of respiratory physiotherapy as adjuvant therapy in patients with COVID-19 admitted to the ICU; a development opportunity	de Bilbao,  GM	Gaceta Medica de Bilbao	Commentary/Editorial| Commentaire/Éditorial
33031513; Long-term Health Consequences of COVID-19	Del Rio,  C,  Collins, et al	JAMA - Journal of the American Medical Association	Commentary/Editorial| Commentaire/Éditorial
33058628; Covid-19 or the great disarmament	Deleuze,  J	La Revue du praticien	Commentary/Editorial| Commentaire/Éditorial
Is there a role for childhood vaccination against COVID-19?	Eberhardt,  CS,  Siegrist, et al	Pediatr Allergy Immunol	Commentary/Editorial| Commentaire/Éditorial
Outpatient services post-COVID-19: A paradigm drift or shift?	Edwards,  L,  Millington, et al	British Journal of Health Care Management	Commentary/Editorial| Commentaire/Éditorial
Adapting to the Coronavirus Pandemic: Building and Incorporating a Diagnostic Pipeline in a Shared Resource Laboratory	Emma,  R,  Ana, et al	Cytometry A	Commentary/Editorial| Commentaire/Éditorial
33058115; Antibiotics - Self Medication, BCG Scar and the On-Going Challenge of Covid-19	Erhabor,  GE	West African journal of medicine	Commentary/Editorial| Commentaire/Éditorial
A Biomarker-Centric Approach to Drug Discovery and Development: Lessons Learned from the COVID-19 Pandemic	Fader,  KA,  Zhang, et al	J Pharmacol Exp Ther	Commentary/Editorial| Commentaire/Éditorial
Cardiac Involvement After Recovering From COVID-19	Filippetti,  L,  Pace, et al	JAMA Cardiol	Commentary/Editorial| Commentaire/Éditorial
COVID-19 in Afrika Afrika scheint sicherer als Europa	Fischer-Fels,  J	Deutsches Arzteblatt International	Commentary/Editorial| Commentaire/Éditorial
Lockdown, public good and equality during COVID-19	Frith,  L	J Med Ethics	Commentary/Editorial| Commentaire/Éditorial
Striving for Inclusive Excellence in the Recruitment of Diverse Surgical Residents During COVID-19	Gerull,  KM,  Enata, et al	Acad Med	Commentary/Editorial| Commentaire/Éditorial
Catecholamine physiology and its implications in patients with COVID-19	Gubbi,  Sriram,  Nazari, et al	The Lancet Diabetes & Endocrinology	Commentary/Editorial| Commentaire/Éditorial
No-Fault Compensation for Vaccine Injury - The Other Side of Equitable Access to Covid-19 Vaccines	Halabi,  S,  Heinrich, et al	N Engl J Med	Commentary/Editorial| Commentaire/Éditorial
32515324; CT-fund gav mistanke om COVID-19-infektion	Hansen,  IV,  Andersen, et al	Ugeskrift for laeger	Commentary/Editorial| Commentaire/Éditorial
“Responding to an epidemic requires a compassionate state”: How has the Indian state been doing in the time of Covid-19?	Harriss,  J	Journal of Asian Studies	Commentary/Editorial| Commentaire/Éditorial
33054139; SARS-CoV-2 severity in african americans - A role for Duffy Null?	Hebbel,  RP,  Vercellotti, et al	Haematologica	Commentary/Editorial| Commentaire/Éditorial
Death sentencing by Zoom: An actor-network theory analysis	Heinsch,  M,  Sourdin, et al	Alternative Law Journal	Commentary/Editorial| Commentaire/Éditorial
Open knowledge commons versus privatized gain in a fractured information ecology: Lessons from COVID-19 for the future of sustainability	Hensher,  M,  Kish, et al	Global Sustainability	Commentary/Editorial| Commentaire/Éditorial
Coping with the New Normal Imposed by the COVID-19 Pandemic: Lessons for Technology Management and Governance	Herath,  T,  Herath, et al	Information Systems Management	Commentary/Editorial| Commentaire/Éditorial
Coping with COVID-19 Challenges: Experiences of a Solo Librarian in Ireland	Hornung,  E	International Information and Library Review	Commentary/Editorial| Commentaire/Éditorial
One Biosecurity: a unified concept to integrate human, animal, plant, and environmental health	Hulme,  PE	Emerg Top Life Sci	Commentary/Editorial| Commentaire/Éditorial
33058404; Responding to the COVID-19 pandemic: The role of occupational health services in a tertiary hospital in Singapore	Hwang,  J,  Yong, et al	Journal of occupational health	Commentary/Editorial| Commentaire/Éditorial
E-learning of medical residents during COVID-19: perspective from a developing nation	Ish,  P,  Sakthivel, et al	Postgrad Med J	Commentary/Editorial| Commentaire/Éditorial
The Lab Must Go On	Jackson,  BR,  Genzen, et al	Am J Clin Pathol	Commentary/Editorial| Commentaire/Éditorial
Misoprostol in the era of COVID-19: a love letter to the original medical abortion pill	Jayaweera,  RT,  Moseson, et al	Sex Reprod Health Matters	Commentary/Editorial| Commentaire/Éditorial
33070502; Fighting an Infodemic in the Time of the COVID-19 Pandemic in India: Leveraging Technology and Social Media	Jindal,  S,  Anand, et al	Journal of preventive medicine and public health = Yebang Uihakhoe chi	Commentary/Editorial| Commentaire/Éditorial
Editorial: Social media use in children and adolescents - on the good or the bad side of the force?	Kaess,  M	Child Adolesc Ment Health	Commentary/Editorial| Commentaire/Éditorial
Coronaphobia - An Emerging Mental Disorder Super-Spreading Globally by Communication	Kalk,  Andreas,  Van Damme, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
The media spectacle of a techno-city: Covid-19 and the South Korean experience of the state of emergency	Kang,  J	Journal of Asian Studies	Commentary/Editorial| Commentaire/Éditorial
Covid-19: risks to healthcare workers and their families	Karlsson,  U,  Fraenkel, et al	Bmj	Commentary/Editorial| Commentaire/Éditorial
Wisdom to make communication resilient to the crisis: Learning from a Japanese community and social worker	Kawamura,  Y	Asia Pacific Journal of Social Work and Development	Commentary/Editorial| Commentaire/Éditorial
Stabilizing mast cells by commonly used drugs: a novel therapeutic target to relieve post-COVID syndrome?	Kazama,  I	Drug Discov Ther	Commentary/Editorial| Commentaire/Éditorial
Effectively Caring for Individuals With Behavioral and Psychological Symptoms of Dementia During the COVID-19 Pandemic	Keng,  A,  Brown, et al	Frontiers in Psychiatry	Commentary/Editorial| Commentaire/Éditorial
The 3C's: COVID-19, Children, and Cardiac Surgery - Do we know enough?	Khanna,  S	Braz J Cardiovasc Surg	Commentary/Editorial| Commentaire/Éditorial
The beneficial and pathogenic roles of complement in COVID-19	Kim,  AHJ,  Wu, et al	Cleve Clin J Med	Commentary/Editorial| Commentaire/Éditorial
Meeting the need: Creation of an online infection prevention course by the Golisano Institute for Developmental Disability Nursing for direct support professionals during COVID-19	Kiss,  EA,  Redlo, et al	J Intellect Disabil	Commentary/Editorial| Commentaire/Éditorial
33069186; Beyond Genomes and the Covid-19 Pandemic	Kostrouch,  Z	Folia biologica	Commentary/Editorial| Commentaire/Éditorial
Angiotensin-II receptor blockers or angiotensin converting enzyme inhibitors for the treatment of hypertension amid COVID-19 pandemic	Kow,  CS,  Hasan, et al	Expert Rev Cardiovasc Ther	Commentary/Editorial| Commentaire/Éditorial
Telehealth in an acute ophthalmic setting during COVID-19 lock-down	Lam,  D,  Downie, et al	Clin Exp Ophthalmol	Commentary/Editorial| Commentaire/Éditorial
Spectacle as a response the COVID-19 pandemic	Latief,  F,  Haque, et al	Economic and Political Weekly	Commentary/Editorial| Commentaire/Éditorial
Community rehabilitation teams and COVID-19: Rehabilitation demand and innovation in delivery	Lavin,  N,  Farrar, et al	British Journal of Health Care Management	Commentary/Editorial| Commentaire/Éditorial
Consensus Statement on Coronary Intervention during the Coronavirus Disease 2019 (COVID-19) Pandemic: from the Korean Society of Interventional Cardiology (KSIC)	Lee,  KY,  Lee, et al	Korean Circ J	Commentary/Editorial| Commentaire/Éditorial
Potential drawbacks of frequent asymptomatic COVID-19 testing	Lippi,  G,  Henry, et al	Infect Control Hosp Epidemiol	Commentary/Editorial| Commentaire/Éditorial
Covid-19: Is a second wave hitting Europe?	Looi,  MK	Bmj	Commentary/Editorial| Commentaire/Éditorial
T-cell immunobiology and cytokine storm of COVID-19	Luo,  XH,  Zhu, et al	Scand J Immunol	Commentary/Editorial| Commentaire/Éditorial
To mask or not to mask amid the COVID-19 pandemic: how Chinese students in America experience and cope with stigma	Ma,  Y,  Zhan, et al	Chinese Sociological Review	Commentary/Editorial| Commentaire/Éditorial
How pharmacist prescribers can help meet the mental health consequences of COVID-19	Macdonald,  O,  Smith, et al	Evid Based Ment Health	Commentary/Editorial| Commentaire/Éditorial
Covid-19: UK deaths near 60 000 as leaders call for realism about what NHS can handle	Mahase,  E	Bmj	Commentary/Editorial| Commentaire/Éditorial
Covid-19: Antibody prevalence in England fell from 6.0% to 4.4% over three months, study finds	Mahase,  E	Bmj	Commentary/Editorial| Commentaire/Éditorial
Cardiac Involvement After Recovering From COVID-19	Malek,  LA	JAMA Cardiol	Commentary/Editorial| Commentaire/Éditorial
Newly formed empowered 'Technology group' and COVID-19	Mani,  S,  Nabar, et al	Economic and Political Weekly	Commentary/Editorial| Commentaire/Éditorial
Pandemic Tech Utopias and Capitalist Surveillance Cultures: The Case of Privacy-Preserving Contact-Tracing Apps	Mann,  Monique,  Mitchell, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Response to the COVID-19 pandemic among people experiencing homelessness in congregant living settings in San Diego, CA	Marquez,  H,  Ramers, et al	Clin Infect Dis	Commentary/Editorial| Commentaire/Éditorial
Adaptive, diverse and de-centralized diagnostics are key to the future of outbreak response	Matthews,  Q,  da Silva, et al	BMC Biol	Commentary/Editorial| Commentaire/Éditorial
Improving the primary care learning experience for medical students in the wake of COVID-19	McCance,  A	Educ Prim Care	Commentary/Editorial| Commentaire/Éditorial
Olympic recoveries	McDonald,  K	Journal of Asian Studies	Commentary/Editorial| Commentaire/Éditorial
Death anxiety, loss, and grief in the time of covid-19	Menzies,  RE,  Neimeyer, et al	Behaviour Change	Commentary/Editorial| Commentaire/Éditorial
COVID-19 Beteiligung der Neuroglia könnte häufige neurologische Symptome erklären	Meyer,  R	Deutsches Arzteblatt International	Commentary/Editorial| Commentaire/Éditorial
Stellungnahme der DeGIR zur Problematik der Verschiebung interventioneller Eingriffe während der COVID-19-Pandemie	Minko,  P,  Bücker, et al	Rofo	Commentary/Editorial| Commentaire/Éditorial
PMC7463152; Iran's success in controlling the COVID-19 pandemic	Mohammadzadeh,  N,  Shahriary, et al	Infect Control Hosp Epidemiol	Commentary/Editorial| Commentaire/Éditorial
Remote consultations in primary care during the COVID-19 pandemic: student perspectives	Mulvihill,  C,  Cooper, et al	Postgrad Med J	Commentary/Editorial| Commentaire/Éditorial
PMC7592037; Cardiac injury as prognostic value in COVID-19: more remains to be clarified	Mumoli,  N,  Cei, et al	Intern Emerg Med	Commentary/Editorial| Commentaire/Éditorial
British Columbia Provincial Corrections’ Response to the COVID-19 Pandemic: A Case Study of Correctional Policy and Practice	Murdoch,  DJ	Victims and Offenders	Commentary/Editorial| Commentaire/Éditorial
Medical and health informatics services during and after the COVID-19 pandemic should be virtual, tailored, responsive and interactive: a case study in Belgium	N,  SP,  De Meulemeester, et al	Health Info Libr J	Commentary/Editorial| Commentaire/Éditorial
33062123; COVID-19, gram-negative sepsis and a pleuro-peritoneal leak	Naidoo,  P,  Naidoo, et al	The Pan African medical journal	Commentary/Editorial| Commentaire/Éditorial
(Mis)communicating about COVID-19: Insights from Health and Crisis Communication	Noar,  SM,  Austin, et al	Health Commun	Commentary/Editorial| Commentaire/Éditorial
33070501; Beyond SARS-CoV-2: Lessons That African Governments Can Apply in Preparation for Possible Future Epidemics	Oboh,  MA,  Omoleke, et al	Journal of preventive medicine and public health = Yebang Uihakhoe chi	Commentary/Editorial| Commentaire/Éditorial
The Covid-19 Era: The View From Nigeria	Oleribe,  OO,  Oskouipour, et al	Qjm	Commentary/Editorial| Commentaire/Éditorial
COVID-19: The older adult and the importance of Vitamin D sufficiency	O'Shea,  PM,  Griffin, et al	Journal of Nutritional Science	Commentary/Editorial| Commentaire/Éditorial
COVID-19 Disease Map, a computational knowledge repository of SARS-CoV-2 virus-host interaction mechanisms	Ostaszewski,  Marek,  Niarakis, et al	bioRxiv	Commentary/Editorial| Commentaire/Éditorial
The Impact of COVID-19 and its Policy Responses on Local Economy and Health Conditions	Öztekin,  Özde	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Safety Risks of Urban Spatial Agglomeration and Their Prevention and Control: Based on the Prevention and Control of Coronavirus (COVID-19) Pandemic	Pan,  J	Chinese Journal of Urban and Environmental Studies	Commentary/Editorial| Commentaire/Éditorial
Escalation and de-escalation of the radiology response to COVID-19 in a tertiary hospital in South London: The King's College Hospital experience	Panayiotou,  A,  Rafailidis, et al	Br J Radiol	Commentary/Editorial| Commentaire/Éditorial
A Scientist and Servant-Leader to Heal COVID-19	Pandikattu,  Kuruvilla	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Contamination of surroundings by coronavirus SARS-CoV-2: Where are the "hot spots" in the patient's room?	Panknin,  HT,  Trautmann, et al	Hygiene + Medizin	Commentary/Editorial| Commentaire/Éditorial
Fears of COVID-19 Contagion and the Italian Prison System Response	Pattavina,  A,  Palmieri, et al	Victims and Offenders	Commentary/Editorial| Commentaire/Éditorial
The challenge of environmental sustainability in radiology training and potential solutions	Peters,  S,  Burrows, et al	Postgrad Med J	Commentary/Editorial| Commentaire/Éditorial
COVID-19 and Interstitial Lung Disease: Keep Them Separate	Podolanczuk,  AJ,  Richeldi, et al	Am J Respir Crit Care Med	Commentary/Editorial| Commentaire/Éditorial
33022035; Risk of COVID-19 during Air Travel	Pombal,  R,  Hosegood, et al	JAMA - Journal of the American Medical Association	Commentary/Editorial| Commentaire/Éditorial
Afterword: Lives interrupted, trends continued?	Pomeranz,  K	Journal of Asian Studies	Commentary/Editorial| Commentaire/Éditorial
33054266; Turnaround times - the Achilles' heel of community screening and testing in Cape Town, South Africa: A short report	Porter,  JD,  Mash, et al	African journal of primary health care & family medicine	Commentary/Editorial| Commentaire/Éditorial
33058643; SARS-CoV-2 infection: do not neglect neurological symptoms!	Pouga,  L	La Revue du praticien	Commentary/Editorial| Commentaire/Éditorial
Editorial Comment to Nosocomial SARS-CoV-2 infection in urology departments: Results of a prospective multicentric study	Puliatti,  S,  Eissa, et al	Int J Urol	Commentary/Editorial| Commentaire/Éditorial
Cardiac Involvement After Recovering From COVID-19-Reply	Puntmann,  V,  Nagel, et al	JAMA Cardiol	Commentary/Editorial| Commentaire/Éditorial
Diagnosis of Coronavirus Disease (COVID-19) Pneumonia: Is Lung Ultrasound the Better Choice?	Quarato,  CMI,  Venuti, et al	AJR Am J Roentgenol	Commentary/Editorial| Commentaire/Éditorial
A fiber optic-nanophotonic approach to the detection of antibodies and viral particles of COVID-19	Rajil,  N,  Sokolov, et al	Nanophotonics	Commentary/Editorial| Commentaire/Éditorial
Covid-19: More must be done to protect ethnic minority communities in the second wave, review says	Rimmer,  A	Bmj	Commentary/Editorial| Commentaire/Éditorial
Maternal request caesareans and COVID-19: the virus does not diminish the importance of choice in childbirth	Romanis,  EC,  Nelson, et al	J Med Ethics	Commentary/Editorial| Commentaire/Éditorial
Myocardial Revascularization Surgery in COVID-19: Choosing the Most Opportune Moment for Intervention	Rosado,  ADR,  Mesacasa, et al	Braz J Cardiovasc Surg	Commentary/Editorial| Commentaire/Éditorial
Audio Interview: A New Monoclonal Antibody for Covid-19	Rubin,  EJ,  Baden, et al	N Engl J Med	Commentary/Editorial| Commentaire/Éditorial
Education crisis: Neoliberal constructivism. Notes in pandemic contexts	Rubio-Gaviria,  D	Praxis Educativa	Commentary/Editorial| Commentaire/Éditorial
New data on soluble ACE2 in patients with atrial fibrillation reveal potential value for treatment of patients with COVID-19 and cardiovascular disease	Sama,  IE,  Voors, et al	Eur Heart J	Commentary/Editorial| Commentaire/Éditorial
Moving teaching online during the COVID-19 pandemic	Sands,  D,  Kormos, et al	Europhysics News	Commentary/Editorial| Commentaire/Éditorial
Can AI help in the fight against COVID-19?	Scott,  IA,  Coiera, et al	Med J Aust	Commentary/Editorial| Commentaire/Éditorial
The Role of Dentists in COVID-19 Is Beyond Dentistry: Voluntary Medical Engagements and Future Preparedness	Seneviratne,  CJ,  Lau, et al	Frontiers in Medicine	Commentary/Editorial| Commentaire/Éditorial
Psychotherapy in the time of COVID-19 (psychotherapy changes shape and steps forward)	Shadbolt,  C	Psychotherapy and Politics International	Commentary/Editorial| Commentaire/Éditorial
From Crubbing Pollution to Restoring Spaces	Sharma,  Alka,  Sharma, et al	SSRN- Lancet prepublication	Commentary/Editorial| Commentaire/Éditorial
Physical education role during coronavirus disease 2019 (COVID-19) pandemic Physical education and COVID-19	Silva-Filho,  E,  Teixeira, et al	Motriz.Revista de Educacao Fisica	Commentary/Editorial| Commentaire/Éditorial
Coronary Artery Bypass Graft During the COVID-19 Pandemic	Silveira,  Lmvd,  Guerreiro, et al	Braz J Cardiovasc Surg	Commentary/Editorial| Commentaire/Éditorial
33059878; La pandémie de COVID-19 ne sera pas la dernière (ni la pire) : Il est temps d'intégrer la résilience à nos objectifs d'élimination du cancer du col de l'utérus	Steben,  M,  Norris, et al	Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC	Commentary/Editorial| Commentaire/Éditorial
Researchers Continue Quest to Contain Spread of COVID-19	Tibbetts,  JH	Bioscience	Commentary/Editorial| Commentaire/Éditorial
From the Quarantine to the General Strike: On Bataille’s Political Economy1	Timofeeva,  O	Stasis	Commentary/Editorial| Commentaire/Éditorial
PMC7591691; The microscope drape method to reduce aerosolisation during endoscopic sinus and skull base surgery in the COVID era. How i do it	Tsagkovits,  A,  Ioannidis, et al	Eur Arch Otorhinolaryngol	Commentary/Editorial| Commentaire/Éditorial
Covid-19: Medicijn per inhaler mogelijk beter	Van Den Houdt,  F	Pharmaceutisch weekblad	Commentary/Editorial| Commentaire/Éditorial
The COVID-19 pandemic and the crisis of the social sciences	Visvanathan,  S	Economic and Political Weekly	Commentary/Editorial| Commentaire/Éditorial
33069187; Transfer Factor as an Option for Managing the COVID-19 Pandemic	Viza,  D,  Pizza, et al	Folia biologica	Commentary/Editorial| Commentaire/Éditorial
Optimal Questionnaires for Screening of Strategic Agents	Vora,  AnujS,  Kulkarni, et al	arXiv	Commentary/Editorial| Commentaire/Éditorial
COVID-19-Associated Acute Kidney Injury: Learning from the First Wave	Wald,  R,  Bagshaw, et al	J Am Soc Nephrol	Commentary/Editorial| Commentaire/Éditorial
Commentary on 'Will vaccination refusal prolong the war on SARS-CoV-2?'	Welsby,  PD	Postgrad Med J	Commentary/Editorial| Commentaire/Éditorial
33057226; How anti-ageing drugs could boost COVID vaccines in older people	Willyard,  C	Nature	Commentary/Editorial| Commentaire/Éditorial
Thinking differently: Lessons learned by international public health specialists while supporting the Integrated Disease Surveillance and Response system in Pakistan	Wilson,  A,  Cartwright, et al	BMJ Global Health	Commentary/Editorial| Commentaire/Éditorial
Covid-19: Official data on England are patchy, say researchers behind new evaluation dashboard	Wise,  J	Bmj	Commentary/Editorial| Commentaire/Éditorial
Elective Surgery during the Covid-19 Pandemic	Wu,  K,  Smith, et al	N Engl J Med	Commentary/Editorial| Commentaire/Éditorial
COVID-19, the Anthropocene, and the Imperative of US-China Cooperation	Wu,  T	Ecohealth	Commentary/Editorial| Commentaire/Éditorial
Reply to "Diagnosis of Coronavirus Disease (COVID-19) Pneumonia: Is Lung Ultrasound the Better Choice?"	Xue,  H,  Cui, et al	AJR Am J Roentgenol	Commentary/Editorial| Commentaire/Éditorial
Isolation or De-isolation: Measuring the Infectivity of SARS-CoV-2?	Yang,  HC	Clin Infect Dis	Commentary/Editorial| Commentaire/Éditorial
33070480; Inhalation Sedation During the COVID-19 Outbreak: An Expert Opinion	Yanko,  R,  Klitinich, et al	The Israel Medical Association journal : IMAJ	Commentary/Editorial| Commentaire/Éditorial
Is it wise to open up America again now? Learning from government responses to COVID-19 and economy reopen points in three Asia-Pacific countries	Yu,  J,  Pang, et al	British Journal of Health Care Management	Commentary/Editorial| Commentaire/Éditorial
Ending COVID-19: progress and gaps in research-highlights of the July 2020 GloPID-R COVID-19 Research Synergies Meetings		BMC Med	Commentary/Editorial| Commentaire/Éditorial
COVID research updates: A fur-farm animal can spread the coronavirus		Nature	Commentary/Editorial| Commentaire/Éditorial
Assigning OR staff members to assist anesthesia professionals during the COVID-19 pandemic		Aorn j	Commentary/Editorial| Commentaire/Éditorial
Patient Management and Clinical Recommendations during the Coronavirus (COVID-19) Pandemic (as of March 17, 2020)		Obstetrical and Gynecological Survey	Commentary/Editorial| Commentaire/Éditorial
33060225; Latest Covid-19 survey provides good news		The Veterinary record	Commentary/Editorial| Commentaire/Éditorial
HealthRecSys 2020 - Proceedings of the 5th International Workshop on Health Recommender Systems, co-located with the 14th ACM Conference on Recommender Systems 2020, RecSys 2020			Commentary/Editorial| Commentaire/Éditorial
WiNTECH 2020 - Proceedings of the 14th ACM Workshop on Wireless Network Testbeds, Experimental evaluation and CHaracterization, Part of ACM MobiCom 2020			Commentary/Editorial| Commentaire/Éditorial

Appendix: Process and definitions. 

A daily search for new publications is conducted in PubMed, Scopus, BioRxiv and MedRxiv, SSRN, Research Square, arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2 OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database.  The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google.  Publishers include Lancet, Elsevier, The New England Journal of Medicine, BMJ, Wiley, Springer Nature, ChinaCDCweekly. Additionally the database is cross-referenced with other literature scans and activities by collaborators.  Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa Waddell for additional information: Lisa.Waddell@canada.ca.  References are compiled in a reworks database that has citations since the beginning of the outbreak.  All references can be accessed at this link and by the categories listed below.  The daily scan has also been compiled in an excel sheet and copies can be provided upon request or accessed here.

Category Definitions:

Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely to influence future results.

Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro, attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*

Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.

Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well as clinical profiles of patients; presenting symptoms, symptoms over course of illness, sequelae, comorbidities.* 

Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data.  Surveillance data will likely be number of cases suspected/confirmed, number of deaths, number recovered. *

Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses

Diagnostics / Pathogen detection:  All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.

Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.

Vaccine Research:  Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.

Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.

Public Health interventions*: Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).

Public Health response: These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.

Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC

Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to:  set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.

Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.

Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)

Animal Model: An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the added risk of harming an actual human.

Zoonotic: all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.

Review Literature:  All articles that summarize the published literature can be tagged as a review.  This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*

Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary category.

News articles that have not scientific information.

*Lists are not exhaustive

Annexe: Processus et définitions. 

Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus, BioRxiv and MedRxiv, SSRN, Research Square, arXiv pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV).  La saisie renvoie à des annonces de publication sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google.  Parmi les éditeurs figurent Lancet, Elsevier, The New England Journal of Medicine, BMJ, Wiley, Springer Nature, ChinaCDCweekly.  En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.  Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au : Lisa.Waddell@canada.ca.  Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie.  Toutes les références sont accessibles à partir de ce lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées ici.

Définitions des catégories :

Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats. Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.

Épidémiologie : Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque, le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.

Transmission : Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.

Données cliniques des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.* 

Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.  Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *

Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.

Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes, etc.

Thérapeutique : Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.

Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.

Priorités de santé publique : Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.

Interventions de santé publique* : Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).

Réponse de la santé publique : Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.

Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) : Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.

Réponse des soins de santé : Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment :  mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux / stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.

Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)

Modèle animal: Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.

Zoonotic: all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.

Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19

Revue de la documentation :  Tous les articles qui résument les documents publiés peuvent être marqués comme une revue.  Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.

Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.

journaux Articles de presse qui n'ont pas d'informations scientifiques.

* Les listes ne sont pas exhaustives