Good afternoon,
There are 538 citations in today’s scan. 261 were considered primary research or review literature.
Highlights today include:
CANADA
·
Paul et al
(PHO [preprint]) conducted a study aimed at identifying characteristics associated with higher household transmission of SARS-CoV-2 in Ontario, Canada. Between January and July, 2020, there were 26,152 cases of COVID-19 residing in 21,226 households.
Longer testing and male sex were associated with greater odds of household secondary transmission, while being a healthcare worker was associated with lower odds of transmission. Neighbourhoods with larger average economic family size and a higher proportion
of households with multiple persons per room were also associated with greater odds of transmission
·
Shoukat et al., designed an agent-based model integrating age, and parameterized it according to the age structure of each province
and the first estimates of the characteristics of COVID-19 for all provinces in Canada. The number of intensive care beds in the provinces varies between 0.63 and 1.85 per 10,000 inhabitants. Assuming an occupancy rate of 80%, we calculated that the number
of beds available to treat patients with COVID-19 varied between 0.13 and 0.37 per 10,000 population. The average number of additional beds needed would then be 31 per 10,000 inhabitants, or 24.4% less than in the absence of voluntary isolation.
PUBLIC HEALTH INTERVENTIONS
·
Coccia M.
conducted a comparative analysis of some European countries with a longer and shorter national lockdown period during the first wave of COVID-19. Findings suggest that: a) countries with a shorter period of lockdown have a variation of confirmed cases/population
(%) higher than countries with a longer period of lockdown; b) countries with a shorter period of lockdown have an average fatality rate (5.45%) lower than countries with a longer period of lockdown (12.70%), whereas the variation of fatality rate from August
to March 2020 suggests a higher reduction in countries with a longer period of lockdown.
TRANSMISSION
·
Rebello
et al report the first newborn in whom SARS-CoV-2 was isolated from umbilical cord blood and two samples of a skin swab by real-time polymerase chain reaction (RT-PCR) immediately after birth, suggesting the occurrence of vertical transmission.
·
Mossong et al
studied the role of school-age children and school settings in SARS-CoV-2 transmission in Luxembourg. While SARS-CoV-2 incidence was much higher in adults aged 20 and above than in children aged 0 to 19 during the first wave in
spring, no significant difference was found during the second wave in early summer. Of the 424 confirmed COVID-19 cases in school-age children and teachers, we estimate that 179 index cases caused 49 secondary transmissions in schools. While some small clusters
of mainly student-to-student transmission within the same class were identified, we did not observe any large outbreaks with multiple generations of infection.
IMMUNOLOGY
·
Seow et al
use sequential serum samples collected up to 94 d post onset of symptoms (POS) from 65 individuals with real-time quantitative PCR-confirmed SARS-CoV-2 infection, we show seroconversion (immunoglobulin (Ig)M, IgA, IgG) in >95% of cases and neutralizing
antibody responses when sampled beyond 8 d POS. We show that the kinetics of the neutralizing antibody response is typical of an acute viral infection, with declining neutralizing antibody titres observed after an initial peak, and that the magnitude of this
peak is dependent on disease severity.
VACCINE RESEARCH
·
Rahmani et al.
To construct a trivalent subunit vaccine against SARS, MERS and COVID-19, CTL, HTL, MHC I, and IFN-γ epitopes were predicted. Based on the predicted epitopes, a trivalent multi-epitope vaccine with a molecular weight of 74.8 kDa as a strong antigen,
a non-allergenic, and soluble protein was constructed. The predicted epitopes demonstrated strong potential to stimulate T and B-cell mediated immune responses. Furthermore, codon optimization and in silico cloning guaranteed increased expression.
THERAPEUTICS
·
Chan et al.
reported the discovery and development of SC31, a potent SARS-CoV-2 neutralizing IgG1 antibody, originally isolated from a convalescent patient on day 27 after the onset of symptoms. Therapeutic efficacy was confirmed in SARS-CoV-2-infected hamsters,
where SC31 significantly reduced viral load, decreased lung lesions and inhibited progression to severe disease manifestations.
·
Steinhauer et al. In this study antiseptic mouthwashes based on the actives chlorhexidine (CHX) and octenidine (OCT) were investigated regarding their
efficacy against SARS-CoV-2. The OCT-based formulation was effective within only 15 seconds against SARS-CoV-2, and thus constitutes an interesting candidate for future clinical studies to prove its effectiveness in a potential prevention of SARS-CoV-2 transmission
by aerosols.
CORONAVIROLOGY
·
Plante et al, demonstrate D614G, SARS-CoV-2 spike protein mutation, enhances replication on human lung epithelial cells and primary human airway tissues through an
improved infectivity of SARS-CoV-2 virions. The work underscores the importance of this mutation in viral spread, vaccine efficacy, and antibody therapy
ANIMAL MODEL - CORONAVIROLOGY
·
Bouricha et al.
used an in silico approach to predict the animals with high susceptibility to SARS-CoV-2 infection by modelling and studying the Spike–ACE2 interaction of 22 domestic and wild animals. All studied animals were potentially susceptible to infection with
slight differences in binding affinity and stability of their ACE2-RBD complexes.
·
Ul-Rahman et al
conducted an in silico analysis of all the coding gene sequences of SARS-CoV-2 strains originating from a range of non-human mammalian species, including pangolin, bat, dog, cat, tiger, mink, mouse, and the environmental samples such as wastewater, air
and surface samples from the door handle and seafood market. Compared to the reference SARS-CoV-2 strain (MN908947; Wuhan-Hu-1), phylogenetic and comparative residue analysis revealed the circulation of three variants, including hCoV-19 virus from humans and
two hCoV-19-related precursors from bats and pangolins. A lack of obvious differences as well as a maximum genetic homology among dog-, cat-, tiger-, mink-, mouse-, bat- and pangolin-derived SARS-CoV-2 sequences suggested a likely evolution of these strains
from a common ancestor
PUBLIC HEALTH RESPONSE
·
Loomba et al.
(preprint) measured the impact of exposure to COVID-19 vaccine misinformation on vaccine intent in the UK and US. We show that recent misinformation around a COVID-19 vaccine induces a fall in vaccination intent among those who would otherwise 'definitely'
vaccinate by 6.4% in the UK and 2.4% in the US. We find evidence that socio-econo-demographic, political, and trust factors are associated with low intent to vaccinate and susceptibility to misinformation. We find evidence that scientific-sounding misinformation
relating to COVID-19 and vaccines lowers vaccination intent, while corresponding factual information does not. These findings reveal how recent COVID-19 misinformation can impact vaccination rates and suggest pathways to robust messaging campaigns.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura
Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
|
PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Manufactured Maladies: Lives and Livelihoods of Migrant Workers During COVID-19 Lockdown in India |
Adhikari, A, Goregaonkar, et al |
Indian Journal of Labour Economics |
Public Health response| Interventions de santé publique |
In this article, we draw on the work of Stranded Workers Action Network (SWAN) with more analysis and perspective.
SWAN was a spontaneous relief effort that emerged soon after the lockdown was announced in March 2020. In addition to providing relief, SWAN concurrently documented the experiences of over 36,000 workers through the lockdown. We highlight the inadequacy of
the government and judicial response to the migrant worker crisis. We present quantitative data elaborating the profile of workers that reached out to SWAN, the extent of hunger, loss of livelihoods and income. We also present qualitative insights based on
interactions with workers and discuss multiple, non-exhaustive, dimensions of vulnerability to which migrant workers were exposed. |
|
Agha, S |
Ethics Med Public Health |
Public Health response| Interventions de santé publique |
Investigated the link between the four-factor structure model of coping and mental health among those living in lockdown. Overall, the results showed
high levels of stress, anxiety and depression among participants. These findings revealed a significant association between active avoidance and religious/denial coping strategies and mental health problems. However, problem-focused and positive coping strategies
were found to be insignificant for all three mental health problems. Other social and personal factors, such as being away from family (90%), having problems sleeping (86%), worrying about the future (85%), experiencing anger (83%), lacking emotional support
(79%) and having fear of receiving bad news (72%), were reported often by participants. |
|
|
Alagoz, O, Sethi, et al |
Ann Intern Med |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health interventions*| Interventions
de santé publique |
Determined the effect of social distancing measures in specific regions with varying population demographic characteristics and different levels of adherence
to social distancing. The timing of and adherence to social distancing had a major effect on COVID-19 occurrence. In NYC, implementing social distancing measures 1 week earlier would have reduced the total number of confirmed cases from 203 261 to 41 366 as
of 31 May 2020, whereas a 1-week delay could have increased the number of confirmed cases to 1 407 600. A delay in implementation had a differential effect on the number of cases in the Milwaukee metro area versus Dane County, indicating that the effect of
social distancing measures varies even within the same state. |
|
|
Alavi Darazam, I, Hatami, et al |
Trials |
RCT |
Clinical trial proposal. Will investigate the effectiveness of high dose Interferon Beta 1a, compared to low dose Interferon Beta 1a (the base therapeutic
regimen) in COVID-19 Confirmed Cases (Either RT-PCR or CT Scan Confirmed) with moderate to severe disease. COVID- 19 confirmed patients (using the RT-PCR test or CT scan) will be randomly assigned to one of two groups. The intervention group (Arms1) will be
treated with lopinavir / ritonavir (Kaletra) + high dose Interferon-β 1a (Recigen) and the control group will be treated with lopinavir / ritonavir (Kaletra) + low dose Interferon-β 1a (Recigen) (the base therapeutic regimen). Both groups will receive standard
care consisting of the necessary oxygen support, non-invasive, or invasive mechanical ventilation. Time to clinical improvement is our primary outcome measure. |
|
|
Increasing SARS-CoV-2 RT-qPCR testing capacity by
sample pooling |
Alcoba-Florez, Julia, Gil-Campesino, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here we investigated the potential of using pooling of samples followed by one-step retrotranscription and quantitative PCR (RT-qPCR) to increase SARS-CoV-2
testing capacity. We found that pools of five samples combined with RT-qPCR solutions helped to increase SARS-CoV-2 testing capacity with minimal loss of sensitivity compared to that resulting from testing the samples independently. |
|
Aldila, D |
Chaos Solitons Fractals |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de santé publique |
Proposed a deterministic model governed by a system of nonlinear differential equations which consider the intervention
of media campaign to increase human awareness, and rapid testing to track the undetected cases in the field. Analysis of the autonomous model shows the existence of transcritical bifurcation at a basic reproduction number equal to one. We estimate our parameter
using the incidence data from East Java, Indonesia. Using these parameters, we analyze the sensitivity of the parameters in determining the size of the basic reproduction number. An optimal control problem which transforms media campaign and rapid testing
as a time-dependent control was conducted also in this article. Cost-effectiveness analysis using the Infection averted ratio (IAR) and the Average cost-effectiveness ratio (ACER) conducted to analyze the best strategies to eradicate COVID-19 spread. |
|
|
Almadani, M, Shiferson, et al |
J Vasc Surg Cases Innov Tech |
Clinical data| Données cliniques |
Coronavirus disease 2019 (COVID-19) is an infectious disease typically manifested as a respiratory infection with a
range of symptoms from a mild viral illness to a severe acute respiratory syndrome with multiorgan failure and death. We report a case of a young man presenting with compartment syndrome secondary to COVID-19 viral myositis, with a protracted hospital course
further complicated by extensive venous and arterial thrombosis. As the coronavirus pandemic evolves, our understanding of the virus continues to improve; however, a host of unanswered questions remain about atypical presentation and management and treatment
options. |
|
|
Bots as active news promoters: A digital analysis
of covid-19 tweets |
Al-Rawi, A, Shukla, et al |
Information (Switzerland) |
Public Health response| Interventions de santé publique |
In this study, we examined the activities of automated social media accounts or bots that tweet or retweet referencing
#COVID-19 and #COVID19. From a total sample of over 50 million tweets, we used a mixed method to extract more than 185,000 messages posted by 127 bots. Our findings show that the majority of these bots tweet, retweet and mention mainstream media outlets, promote
health protection and telemedicine, and disseminate breaking news on the number of casualties and deaths caused by COVID-19. We argue that some of these bots are motivated by financial incentives, while other bots actively support the survivalist movement
by emphasizing the need to prepare for the pandemic and learn survival skills. We only found a few bots that showed some suspicious activity probably due to the fact that our dataset was limited to two hashtags often used by official health bodies and academic
communities. |
|
Alshareef, Reem, Al Zahrani, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
The novel COVID-19 pandemic has affected the performance and well-being of the medical staff working during the pandemic.
This study aims to evaluate the negative effect of the COVID-19 pandemic on the medical training and psychological well-being of resident doctors practicing in the western region in Saudi Arabia by a survey. Of 121 residents that responded to this survey,
71.1% were junior residents, 66.9% had a medical specialty; and 33% were family medicine doctors, followed by 17% from general surgery. In regards to work amid the pandemic, 36.1% were in contact with confirmed COVID-19 patients, and 35.5% had to work overtime
during the pandemic. Of the respondents, 44% described their training as extremely affected, and 32% strongly agreed and 53% agreed that their psychological well-being was negatively affected. There was a non-significant difference detected between the residents
regarding the factors negatively affecting their psychological well-being. |
|
|
Amann, Julia, Sleigh, et al |
medRxiv |
Public Health response| Interventions de santé publique |
The present paper explores how the national daily newspapers in Germany, Austria, and Switzerland reported on the development
and adoption of digital contact-tracing apps during early and after stages of the lockdown. We conducted thematic analysis on news coverage published between January and May 2020 in high-circulation national daily newspapers (print) from Germany, Austria,
and Switzerland. A total of 148 newspaper articles were included in the final analysis. From our analysis emerged six core themes of the development and adoption of digital contact tracing apps: 1) data governance; 2) role of IT giants; 3) scientific rigor;
4) voluntariness; 5) functional efficacy; 6) role of the app. These results shed light on the different facets of discussion regarding digital contact tracing as portrayed in German-speaking media. As news coverage can serve as a proxy for public perception,
this study complements emerging survey data on public perceptions of digital contact tracing apps by identifying potential issues of public concern. |
|
|
Ameh Yaro, C, Udama Eneche, et al |
Int J Environ Health Res |
Modelling/ prediction| Modélisation/prédiction Transmission |
This study evaluated the effect of demographic and environmental variables on the transmission of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) in Nigeria. Daily data on confirmed cases on SARS-CoV-2 were obtained, data layers for environmental and demographic factors were acquired. Using epidemiological, environmental and demographic datasets obtained, the MaxEnt
tool was used to identify the risk areas of SARS-CoV-2 while Getis-Ord Gi* statistics on ArcMap 10.7 was used to identify hotspots for SARS-CoV-2. Southern Nigeria and some states in North-West, North-East and North-Central fell within the high risk and hotspots
zone for SARS-CoV-2 transmission. Literacy level, dependency ratio, population density, age structure, temperature and precipitation were factors that significantly influenced the transmission of SARS-CoV-2 in Nigeria. SARS-CoV-2 infection had a higher in
the Southern than in Northern Nigeria. There is need for the application of an integrative approach to curb the virus. |
|
|
Automated triage of COVID-19 from various lung abnormalities using chest CT features |
Amran, Dor, Frid-Adar, et al |
arXiv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The outbreak of COVID-19 has lead to a global effort to decelerate the pandemic spread. For this purpose chest computed-tomography
(CT) based screening and diagnosis of COVID-19 suspected patients is utilized, either as a support or replacement to reverse transcription-polymerase chain reaction (RT-PCR) test. In this paper, we propose a fully automated AI based system that takes as input
chest CT scans and triages COVID-19 cases. More specifically, we produce multiple descriptive features, including lung and infections statistics, texture, shape and location, to train a machine learning based classifier that distinguishes between COVID-19
and other lung abnormalities (including community acquired pneumonia). We evaluated our system on a dataset of 2191 CT cases and demonstrated a robust solution with 90.8% sensitivity at 85.4% specificity with 94.0% ROC-AUC. In addition, we present an elaborated
feature analysis and ablation study to explore the importance of each feature. |
|
Impacts of the COVID-19 pandemic on life of higher education students: A global perspective |
Aristovnik, A, Keržič, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
The paper presents the most comprehensive and large-scale study to date on how students perceive the impacts of the
first wave of COVID-19 crisis in early 2020 on various aspects of their lives on a global level. The findings also show that students with certain socio-demographic characteristics (male, part-time, first-level, applied sciences, a lower living standard, from
Africa or Asia) were significantly less satisfied with their academic work/life during the crisis, whereas female, full-time, first-level students and students faced with financial problems were generally affected more by the pandemic in terms of their emotional
life and personal circumstances. Key factors influencing students’ satisfaction with the role of their university are also identified. |
|
Early dynamics of transmission and projections of COVID-19 in some West African
countries |
Assob-Nguedia, J, Dongo, et al |
Infectious Disease Modelling |
Modelling/ prediction| Modélisation/prédiction Transmission |
This study analyzes the transmission dynamics of the outbreak in West Africa nearly 5 months after the effective onset.
Policy implications for the effectiveness of control measures and for assessing the potential impact on public health in West Africa are discussed. |
|
Awad, IE, Abu-Saleh, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, we apply an in silico approach to investigate more than 3800 FDA approved drugs on the viral RBD S(1)-ACE2 interface
as a target. The compounds were investigated through flexible ligand docking, ADME property calculations and protein-ligand interaction maps. Molecular dynamics (MD) simulations were also performed on eleven compounds to study the stability and the interactions
of the protein-ligand complexes. The MD simulations show that bagrosin, chidamide, ebastine, indacaterol, regorafenib, salazosulfadimidine, silodosin and tasosartan are relatively stable near the C terminal domain (CTD1) of the S(1) subunit of the viral S
protein. The relative MMGBSA binding energies show that silodosin has the best binding to the target. The constant velocity steered molecular dynamics (SMD) simulations show that silodosin preferentially interacts with the RBD S(1) and has potential to act
as an interfering compound between viral spike-host ACE2 interactions. |
|
|
Baek, YJ, Lee, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Transmission Healthcare Response | Réponse
des soins de santé |
A mathematical model was developed for the COVID-19 transmission within a 2500-bed tertiary hospital of South Korea.
The SEIR (susceptible-exposed-infectious-recovered) model with a compartment of doctor, nurse, patient, and caregiver was constructed. The effects of different intervention strategies such as front door screening, quarantine unit for newly admitted patients,
early testing of suspected infected people, and personal protective equipment for both medical staff and visitors were evaluated. The model suggested that the early testing (within eight hours) of infected cases and monitoring the quarantine ward for newly
hospitalized patients are effective measures for decreasing the incidence of COVID-19 within a hospital (81.3% and 70% decrease of number of incident cases, respectively, during 60 days). Front door screening for detecting suspected cases had only 42% effectiveness.
Screening for prohibiting the admission of COVID-19 patients was more effective than the measures for patients before emergency room or outpatient clinic. This model suggests that under the assumed conditions, some effective measures have a great influence
on the incidence of COVID-19 within a hospital. The implementation of the preventive measures could reduce the size of a hospital outbreak. |
|
|
State anxiety levels of nurses providing care to patients with COVID-19 in Turkey |
Bahadir-Yilmaz, E, Yüksel, et al |
Perspect Psychiatr Care |
Healthcare Response | Réponse des soins de santé |
Investigated the state anxiety levels of nurses providing care to patients with coronavirus disease-2019 (COVID-19)
in Turkey. Nurses' state anxiety levels were high (51.51 ± 9.94). Participants evaluated for state anxiety were female; who were married; worked in intensive care units; were service nurses, having more professional experiences; and experienced hand irritation
(p < 0.05). |
|
PMC7568491; Validation of the Pandemic Emotional Impact Scale |
Ballou, S, Gray, et al |
Brain Behav Immun Health |
Public Health response| Interventions de santé publique |
Validated a questionnaires to comprehensively measure the multi-faceted psychological effects attributable to this
health crisis. The Pandemic Emotional Impact Scale (PEIS) demonstrated excellent internal consistency (Cronbach's α = 0.94) and Guttman split-half reliability (0.95). Exploratory factor analysis suggested two sub-scales -emotional impact and pragmatic worries
- but these were highly correlated with the overall scale score suggesting that the total score can be used in most cases. The PEIS demonstrated good concurrent validity via robust positive correlations with anxiety, depression and stress, and negative correlations
with quality of life and happiness. Criterion validity was supported by the finding that individuals who reported employment loss or loss of income due to the pandemic, had experienced COVID-19 infection in their household, or knew somebody personally who
died from the pandemic, had elevated scores on the PEIS. |
|
Bannur, Nayana, Maheshwari, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In the current work, we propose a novel model-agnostic Bayesian optimization approach for learning model parameters
from observed data that generalizes to multiple application-specific fidelity criteria. Empirical results demonstrate the efficacy of the proposed approach with SEIR-like compartmental models on COVID-19 case forecasting tasks. A city-level forecasting system
based on this approach is being used for COVID-19 response in a few highly impacted Indian cities. |
|
|
Alcohol Consumption in Response to the COVID-19 Pandemic in the United States |
Barbosa, C, Cowell, et al |
J Addict Med |
Public Health response| Interventions de santé publique |
Assessesed differences in alcohol drinking patterns before and after the enactment of stay-at-home orders. Compared
to February, respondents reported consuming more drinks per day in April (+29%), and a greater proportion reported exceeding recommended drinking limits (+20%) and binge drinking (+21%) in April. These differences were found for all sociodemographic subgroups
assessed. February to April differences in the proportion exceeding drinking limits were larger for women than men and for Black, non-Hispanic people than White, non-Hispanic people. |
|
Becker, Daniel, Albery, et al |
bioRxiv |
zoonoses |
Here, we generate an ensemble of seven network- and trait-based statistical models that predict mammal-virus associations,
and we use model predictions to develop a set of priority recommendations for sampling potential bat reservoirs and intermediate hosts for SARS-CoV-2 and related betacoronaviruses. We find nearly 300 bat species globally could be undetected hosts of betacoronaviruses.
Although over a dozen species of Asian horseshoe bats (Rhinolophus spp.) are known to harbor SARS-like viruses, we find at least two thirds of betacoronavirus reservoirs in this bat genus might still be undetected. several civet and pangolin species were
highlighted as high-priority species for viral sampling. |
|
|
Bekelis, K, Missios, et al |
Stroke |
Clinical data| Données cliniques |
To investigate the association between COVID-19 and stroke, we performed a cross-sectional study involving patients
discharged from a healthcare system in New York State, from January to April 2020. Among 24 808 discharges, 2513 (10.1%) were diagnosed with COVID-19, and 566 (0.2%) presented with acute ischemic stroke. Patients diagnosed with COVID-19 were at one-quarter
the odds of stroke compared with other patients (odds ratio, 0.25 95% CI, 0.16-0.40]). This association was consistent in all age groups. Our results were robust in sensitivity analyses, including propensity score-weighted regression models. In patients presenting
with stroke, concurrent infection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) was associated with higher case-fatality (odds ratio,10.50 95% CI, 3.54-31.18]) and a trend towards increased occurrence of discharge to rehabilitation (odds
ratio, 2.45 95% CI, 0.81-1.25]). Using a comprehensive cross-section of patients from a large NY-based healthcare system, we did not identify a positive association between ischemic stroke and COVID-19. However, patients with stroke with COVID-19 had worse
outcomes compared with those without, with over a 9-fold increase in mortality. Although no definitive conclusions can be reached from our observational study, our data do not support the concerns for an epidemic of stroke in young adults with COVID-19. |
|
|
Bezuidenhout, MC, Wiese, et al |
Ann Clin Biochem |
Clinical data| Données cliniques |
Assessed the arterial blood gas (ABG) and acid-base patterns, blood pressure (BP) findings and their association with
the outcomes of COVID-19 patients admitted to an intensive care unit (ICU). A total of 56 ICU patients had admission ABG performed at the time of ICU admission. An alkalaemia (pH > 7.45) was observed in 36 patients. A higher arterial pH median 7.48 (vs. 7.46)
and partial pressure of oxygen in arterial blood PaO2; median 7.9kPa (vs. 6.5kPa) were significantly associated with survival. Survivors also tended to have a higher systolic BP median: 144mmHg (vs. 139mmHg) and higher arterial HCO3 median: 28.0mmol/L (vs.
26.3mmol/L). |
|
|
Structural basis of ribosomal frameshifting during
translation of the SARS-CoV-2 RNA genome |
Bhatt, PramodR, Scaiola, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here we present the cryo-EM structure of the mammalian ribosome in the process of translating viral RNA paused in a
conformation primed for frameshifting. A compound previously shown to reduce frameshifting is able to inhibit SARS-CoV-2 replication in infected cells, establishing coronavirus frameshifting as target for antiviral intervention. |
|
Bolaño-Ortiz, TR, Puliafito, et al |
Sustainability (Switzerland) |
Public health interventions*| Interventions de santé publique |
This work studied the emission changes and their economic effects during the Argentina’s COVID-19 pandemic lockdown.
The results show emissions reduction up to 37% for PM10, PM2.5, and BC, consistent with observed from satellite images and up to 160% for NOx, CO, NMVOC, and SOx. However, the residential sector has increased their emissions by 8% for the same period. As a
consequence, 3337 Gg of CO2eq of GHG emissions were reduced, corresponding to a 20% reduction compared to the same period in 2019. Besides, a 26% reduction in gross domestic product (GDP) was observed due to the COVID-19 pandemic. Our results show that each
Tg of GHG reduction was associated to a 0.16% reduction of the GDP from the analyzed sectors. |
|
|
Bolsover, Gillian |
SSRN- Lancet prepublication |
Economics | Économie |
Analysis of election related tweets in two week-long periods in late May and early July. In the May period, there was
much evidence of conspiracy-style and misinformative content, largely attacking the Democrats, the seriousness of COVID and postal-voting. . In the July period tweets about COVID and the election were dominated by the influence of a new anti-Trump Political
Action Committee's viral videos. Conclusion: the issue of COVID in the US is highly politicised. |
|
|
PMC7566849; Dynamics of a stochastic coronavirus (COVID-19) epidemic model with
Markovian switching |
Boukanjime, B, Caraballo, et al |
Chaos Solitons Fractals |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, we analyze a stochastic coronavirus (COVID-19) epidemic model which is perturbed by both white noise
and telegraph noise incorporating general incidence rate. Firstly, we investigate the existence and uniqueness of a global positive solution. Then, we establish the stochastic threshold for the extinction and the persistence of the disease. The data from Indian
states, are used to confirm the results established along this paper. |
|
Bouricha, EM, Hakmi, et al |
3 Biotech |
Coronavirology| Coronavirologie zoonoses |
The binding capacity of SARS-CoV-2 spike protein to ACE2 is the critical determinant of viral host range and cross-species
infection. Here, we used an in silico approach to predict the potential animals range with high susceptibility to SARS-CoV-2 by modelling and studying the Spike-ACE2 interaction of 22 domestic and wild animals. Our results showed that all studied animals are
potentially susceptible to SARS-CoV-2 infection with a slight difference in the binding affinity and stability of their ACE2-RBD complexes. Furthermore, we identified a specific substitution of tyrosine to histidine at position 41 in ACE2 that likely reduces
the affinity to SARS-CoV-2 in horses and greater horseshoe bats. |
|
|
SARS-CoV-2
IgG Results Among Healthcare Workers in a Rural Upstate New York Hospital System |
Brunner, W, Hirabayashi, et al |
Infect Control Hosp Epidemiol |
Epidemiology| Épidémiologie Immunology | Immunologie |
This letter to the editor describes the results from a study aimed to understand the effectiveness of occupational
infection control measures during the COVID-19 pandemic. Employees of Bassett Healthcare Network were surveyed and tested for SARS-CoV-2 IgG antibodies over May 4, 2020 to May 29, 2020. Among 764 employees tested, 15 were positive for SARS-CoV-2 IgG antibodies
for a seroprevalence of 2.0%, compared to 4.5% for patients (34 seropositives among 762 tested). Of the 764 employees tested, 601 (78.7%) completed the study questionnaire. Seroprevalence among all study participants was 2.0% (12/601) and 3.1% (4/130) in the
random sample. The mean IgG level was 4.93 (range: 2.10-8.14) among seropositives and 0.06 (range: 0.01-1.17) among seronegatives. One-third of seropositives reported a positive PCR test, 8.3% reported a negative PCR test, and 58.3% had no PCR test. Of the
589 seronegative employees, 47 reported having a PCR test (all negative). The findings suggest that employees in a rural healthcare network show that direct patient care was not associated with increased likelihood of COVID-19 infection and that seropositivity
was more likely associated with non-work exposures. |
|
Extending the range of symptoms in a Bayesian Network
for the Predictive Diagnosis of COVID-19 |
Butcher, Rachel, Fenton, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This paper extends a previous Bayesian network designed to predict the probability of COVID-19 infection, based on
a patient's profile. The structure and prior probabilities have been amalgamated from the knowledge of peer-reviewed articles. The network accounts for demographics, behaviours and symptoms, and can mathematically identify multivariate combinations with the
highest risk. Potential applications include patient triage in healthcare systems or embedded software for contact-tracing apps. Specifically, this paper extends the set of symptoms that are a marker for COVID-19 infection and the differential diagnosis of
other conditions with similar presentations. |
|
Clinical manifestations and pathogen characteristics in children admitted for suspected
COVID-19 |
Cai, X, Jiang, et al |
Front Med |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We retrospectively analyzed the clinical data of 97 children with probable COVID-19. A total of 13 (13.4%) patients
were confirmed positive for SARS-CoV-2 infection by nucleic acid RT-PCR testing, and 41 (42.3%) patients were found to be infected with other pathogens that caused pneumonia. Notably, no pathogen was detected in 43 (44.3%) patients. Among all patients, 25
(25.8%) had familial cluster exposure history, and 52 (53.6%) had one or more coexisting conditions. Fifteen (15.5%) patients were admitted or transferred to the PICU. In the 11 confirmed COVID-19 cases, 5 (45.5%) and 7 (63.6%) were positive for IgM and IgG
against SARS-CoV-2, respectively. In 22 patients with suspected COVID-19, 1 (4.5%) was positive for IgG but negative for IgM. The most frequently detected pathogen was Mycoplasma pneumonia (29, 29.9%). One patient with confirmed COVID-19 died. Our results
strongly indicated that the detection of asymptomatic COVID-19 or coexisting conditions must be strengthened in pediatric patients. These cases may be difficult to diagnose as COVID-19 unless etiologic analysis is conducted. A serologic test can be a useful
adjunctive diagnostic tool in cases where SARS-CoV-2 infection is highly suspected but the nucleic acid test is negative. |
|
Cao, Wei, Liu, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
A multi-center retrospective study was conducted to evaluate the effectiveness of IVIg administered within two weeks
of disease onset. High-dose IVIg administered in severe COVID-19 patients within 14 days of onset was linked to reduced 28-day mortality, more prominent with those having no comorbidities or treated at earlier stage. |
|
|
Carriero, Andrea, Clark, et al |
SSRN- Lancet prepublication |
Economics | Économie |
Model the effects of the COVID-19 outbreak on macroeconomic and financial uncertainty. The estimates we obtain yield
very large increases in macroeconomic and financial uncertainty over the course of the COVID-19 period. These increases have contributed to the downturn in economic and financial conditions. |
|
|
Age Advantages in Emotional Experience Persist Even Under Threat From the COVID-19
Pandemic |
Carstensen, LL, Shavit, et al |
Psychol Sci |
Public Health response| Interventions de santé publique |
To address important theoretical questions about age differences in emotional experience in times of crisis, we surveyed
a representative sample of 945 Americans between the ages of 18 and 76 years and assessed the frequency and intensity of a range of positive and negative emotions. We also assessed perceived risk of contagion and complications from the virus, as well as personality,
health, and demographic characteristics. Age was associated with relatively greater emotional well-being both when analyses did and did not control for perceived risk and other covariates. |
|
Casagrande, Marco, Conti, et al |
arXiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
To evaluate the feasibility of both the relay attack and our novel defence mechanism, we developed a proof of concept
against the Italian contact tracing app (i.e., Immuni). The design of our defence allows it to be integrated into any contact tracing app. |
|
|
Pre-endoscopy SARS-CoV-2 testing strategy during
COVID-19 pandemic: The care must go on |
Casper, Markus, Reichert, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
Retrospectively we analysed the gastrointestinal endoscopies performed at the Central Endoscopy Unit of Saarland University
Medical Center during seven weeks from 23 March to 10 May 2020 and present our real-world single-center experience with an individualized rtPCR-based pre-endoscopy SARS-CoV-2 testing ("PECo") strategy. Altogether 359 gastrointestinal endoscopies were performed.
The PECo strategy enabled us to conservatively handle endoscopy program reduction (44% reduction as compared 2019). The results of COVID-19 rtPCR from nasopharyngeal swabs were available in 89% of patients prior to endoscopies. Apart from six patients with
known COVID-19, all other tested patients were negative. The frequencies of endoscopic therapies and clinically significant findings did not differ between patients with or without SARS-CoV-2 tests. |
|
Castoldi, Laura, Solbiati, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
Observational study was performed assessing the volume of emergency surgeries and of the attendances in the ED during
the course of the pandemic (Milan, Lombardy). Reductions in health care utilization categorized. To be determined if untreated patients due to COVID-19 pandemic will result in unwanted consequences on population health. |
|
|
Chan, ConradEZ, Seah, et al |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
We report the discovery and development of SC31, a potent SARS-CoV-2 neutralizing IgG1 antibody, originally isolated
from a convalescent patient at day 27 after the onset of symptoms. We report the discovery and development of SC31, a potent SARS-CoV-2 neutralizing IgG1 antibody, originally isolated from a convalescent patient at day 27 after the onset of symptoms. Therapeutic
efficacy was confirmed in SARS-CoV-2-infected hamsters, where SC31 significantly reduced viral load, decreased lung lesions and inhibited progression to severe disease manifestations. |
|
|
Chen, H, Paris, et al |
Sci Rep |
Public Health response| Interventions de santé publique |
This study examines publicly available online search data in China to investigate the spread of public awareness of
the 2019 novel coronavirus (SARS-CoV-2) outbreak. We found that cities that had previously suffered from SARS (in 2003-04) and have greater migration ties to Wuhan had earlier, stronger and more durable public awareness of the outbreak. Our data indicate that
48 such cities developed awareness up to 19 days earlier than 255 comparable cities, giving them an opportunity to better prepare. |
|
|
Impact of COVID-19 on urology residency in India - Results of a nationwide survey |
Cheriyan, A, Kumar, et al |
Indian Journal of Urology |
Healthcare Response | Réponse des soins de santé |
We conducted a nationwide, cross-sectional, anonymous, online survey among urology residents in India for 3 weeks from
June 21, 2020, to July 11, 2020, to study the impact of COVID-19. Disruption due to COVID-19-related restrictions, fear of infecting family members, nonavailability of adequate PPE, and lack of job opportunities are an added source of anxiety and stress, which
was reported by more than two-thirds of our respondents. |
|
Choi, SE, Yang, et al |
J Gerontol B Psychol Sci Soc Sci |
Epidemiology| Épidémiologie |
OBJECTIVES: This study examines how areas with older populations are affected by COVID-19 and whether urban and rural
counties face different challenges. METHODS: Applying negative binomial regression to a dataset of U.S. counties (N = 3,042), we estimated the relationship between older population ratios and the number of confirmed COVID-19 cases, and how this relationship
changes over time in urban and rural counties, respectively. RESULTS: Although low-ratio counties show the highest number of confirmed cases of COVID-19 at the beginning of the pandemic, confirmed cases in high-ratio counties (more than 25% of the total population
is 65 and older) increase exponentially with time in urban areas. High-ratio rural counties hit their peak later and recover more slowly compared to low- and medium-ratio rural counties. DISCUSSION: Both urban and rural counties with larger older populations
are more vulnerable and their disadvantages in COVID-19 infections are more rapidly exacerbated over time in urban areas. This underscores the importance of early action in those counties for effective intervention and prevention. |
|
|
Chowdhury, FR, Hoque, et al |
Trials |
RCT |
This is a protocol of a multicentre, multi-arm phase II randomised controlled trial. The objective is to assess the
safety, efficacy and dose response of convalescent plasma (CP) transfusion in severe COVID-19 patients. Age and sex matched COVID-19 positive (by RT-PCR) severe cases will be enrolled in this trial. Severe case is defined by the World Health Organization (W.H.O)
clinical case definition. This RCT consists of three arms, a. standard care, b. standard care and 200 ml CP and c. standard care and 400 ml CP. Patients will receive plasma as a single transfusion. Intervention arms will be compared to the standard care arm.
The primary outcome will be time to clinical improvement within seven days of treatment or until discharge whichever is later and in-hospital mortality. The secondary outcome would be improvement of laboratory parameters after therapy (neutrophil, lymphocyte
ratio, CRP, serum ferritin, SGPT, SGOT, serum creatinine and radiology), length of hospital stay, length of ICU stay, reduction in proportion of deaths, requirement of ventilator and duration of oxygen and ventilator support. The protocol is registered on
Clinicaltrials.gov, ID: NCT04403477. |
|
|
Chrulski, T |
Polityka Energetyczna |
Public Health response| Interventions de santé publique Economics | Économie |
The analyzed research problem concerned, in particular, two areas: gas consumption and its prices, in selected European
countries in the aspect of the spread of the COVID-19 epidemic with reference to historical data from 2016-2019. The countries are presented in order or consumption: Germany, the United Kingdom, Italy, France, the Netherlands, Spain, Poland. In the United
Kingdom the level was 11% lower than this time last year. The lowest point was the seven-day period ending April 14 – the Tuesday after the Easter weekend around the height of Covid-19 deaths and the peak of the crisis. In France, a 11 percent-decrease in
natural gas consumption was reported in distribution and 12 percent in final consumers compared to last year. With the ease in lockdown measures in the Netherlands, the economic activity is rebounding with a growing demand for fuel. The Netherlands oil and
gas demand is expected to return to 2019 levels only after 2023 or 2024. The Spanish gas market hit by coronavirus impacted the natural gas demand. The Spanish lockdown squashed front month energy prices. |
|
|
Coccia, Mario |
medRxiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
The main goal of this study is a comparative analysis of some European countries with a longer and shorter period of
national lockdown during the first wave of COVID-19 from March to August 2020. Findings suggests that: a) countries with shorter period of lockdown have a variation of confirmed cases/population (%) higher than countries with longer period of lockdown; b)
countries with shorter period of lockdown have average fatality rate (5.45%) lower than countries with longer period of lockdown (12.70%), whereas variation of fatality rate from August to March 2020 suggests a higher reduction in countries with longer period
of lockdown (-1.9% vs 0.72%). However, Independent Samples Test and the Mann-Whitney test reveal that the effectiveness of longer period of lockdown versus shorter one on public health is not significant. In addition, the COVID-19 pandemic associated with
longer period of lockdown has a higher negative impact on economic growth with consequential social issues in countries. |
|
|
Cole, J, Barnard, et al |
American Journal of Infection Control |
Healthcare Response | Réponse des soins de santé |
This retrospective, cross-sectional study was conducted in four community hospitals in Los Angeles County, California.
The assumption of this study was, coronavirus disease-19 (COVID-19) contributed to the increase in healthcare workers compliance with infection prevention measures. IP initiatives fostered among HCWs have increased awareness of effective hand washing, cleaning
equipment after use and appropriate personal protective equipment use which has subsequently decreased healthcare acquired infections with multidrug-resistant organisms. |
|
|
Corcillo, A, Cohen, et al |
Nephrology (Carlton) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
End stage renal disease (ESRD) is associated with a high mortality rate among patient hospitalised with COVID-19. To
our knowledge, there is limited data on the clinical features, ethnicity, inpatient glycaemic control and outcomes in patients with diabetes related ESRD in the literature. We report the clinical features and outcomes of 39 consecutive ESRD patients 28 on
haemodialysis (HD) and 11 with renal transplant] secondary to diabetic kidney disease admitted to a university hospital with COVID-19. We observed a high prevalence of patients of Afro-Caribbean ethnicity hospitalised with COVID-19 with a 73% and 54% prevalence
in renal transplant and HD groups respectively. . The mortality rate of our cohort was high at 36%. Nearly a one third of HD patients and one fifth of transplant patients had hypoglycaemic events during COVID-19 hospitalisation. Adjustment of diabetes treatment
was also frequently required. Our data highlights the importance of integrated multidisciplinary care of patients with diabetes related ESRD hospitalised with COVID-19. |
|
|
D'Ambrosi, F, Rossi, et al |
Int J Gynaecol Obstet |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This is a retrospective study analysing all pregnant women with gestational diabetes and a concomitant COVID-19 infection
admitted to an institution for antenatal care between March 1(st) and April 30(th) 2020. Among pregnant women with GD and a concomitant COVID-19 infection, the mean age was 32,9 (SD 5,6) years. Two patients (33%) were of Caucasian ethnicity while four (67%)
were non-Caucasian. All patients were diagnosed with COVID-19 during the third trimester of pregnancy. Two women were asymptomatic while four were symptomatic. Only two patients (33,3%) received treatment with insulin. None of the patients required intensive
care or mechanical ventilation. No complications were found among the newborns. |
|
|
D'Anna, L, Sheikh, et al |
BMJ Open |
Healthcare Response | Réponse des soins de santé |
The aim of the study was to investigate whether COVID-19 has resulted in a decreased number of referrals to the transient
ischaemic attack (TIA) clinics across the North West London region. All the TIA clinical leads of the North West London region received an invitation by email to participate in an online survey in May 2020. The survey questionnaire aimed to assess the number
of patients with suspected TIA consecutively referred to each of the TIA clinics of the North West London region between 1 March and 30 April 2020, the COVID-19 period, and between 1 March and 30 April 2019. We had a response rate of 100%. During the COVID-19
period, the TIA clinics of the North West London region received 440 referrals compared with 616 referrals received between 1 March and 30 April 2019 with a fall in the number of the referrals by 28.6%. In April 2020 compared with April 2019, the number of
the referrals declined by 40.1%. This multicentre analysis documented a significant reduction in the number of patients referred with suspected TIA to the specialised rapid access outpatient clinics in the North West London region during the COVID-19 pandemic. |
|
|
Cancer inpatients with COVID-19: A report from the
Brazilian National Cancer Institute |
de Melo, AC, Thuler, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to describe the demographic and clinical characteristics of cancer inpatients with COVID-19 exploring
clinical outcomes. A retrospective search in the electronic medical records of cancer inpatients admitted to the Brazilian National Cancer Institute from April 30, 2020 to May 26, 2020 granted identification of 181 patients with COVID-19 confirmed by RT-PCR.
The mean age was 55.3 years (SD ± 21.1). Comorbidities were present in 110 (60.8%) cases. The most prevalent solid tumors were breast (40 22.1%]), gastrointestinal (24 13.3%]), and gynecological (22 12.2%]). Among hematological malignancies, lymphoma (20 11%])
and leukemia (10 5.5%]) predominated. Metastatic disease accounted for 90 (49.7%) cases. In total, 63 (34.8%) had recently received cytotoxic chemotherapy. The most common complications were respiratory failure (70 38.7%]), septic shock (40 22.1%]) and acute
kidney injury (33 18.2%]). A total of 60 (33.1%) patients died due to COVID-19 complications. For solid tumors, the COVID-19-specific mortality rate was 37.7% (52 out of 138 patients) and for hematological malignancies, 23.5% (8 out of 34). According to the
univariate analysis COVID-19-specific mortality was significantly associated with age over 75 years (P = .002), metastatic cancer (p <0.001), two or more sites of metastases (P < .001), the presence of lung (P < .001) or bone metastases (P = .001), non-curative
treatment or best supportive care intent (P < .001), higher C-reactive protein levels (P = .002), admission due to COVID-19 (P = .009), and antibiotics use (P = .02). After multivariate analysis, cases with admission due to symptoms of COVID-19 (P = .027)
and with two or more metastatic sites (P < .001) showed a higher risk of COVID-19-specific death. |
|
Pulmonary thromboembolism with multiple right heart mural thrombus in a patient
with COVID-19 |
Dehghan, H, Soleimani, et al |
J Echocardiogr |
Clinical data| Données cliniques |
Herein we present a 40-year-old hypertensive otherwise healthy male who was admitted with complaints of myalgia, low
grade fever, dry cough, leg swelling, and exacerbating dyspnea in the last two weeks with history of recent recovery from COVID-19 in his wife. This patient presented with pulmonary thromboembolism accompanied by multiple large right heart thrombus represents
a unique serious form of cardiopulmonary injury during COVID-19 disease. |
|
Dennis, JM, McGovern, et al |
Crit Care Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to measure temporal trends in survival over time in people with severe COVID-19 requiring
critical care management, and to assess whether temporal variation in mortality was explained by changes in patient demographics and comorbidity burden over time. Twenty-one thousand eighty-two critical care patients (high dependency unit n = 15,367; ICU n
= 5,715) were included. Unadjusted survival at 30 days was lowest for people admitted in late March in both high dependency unit (71.6% survival) and ICU (58.0% survival). By the end of June, survival had improved to 92.7% in high dependency unit and 80.4%
in ICU. Improvements in survival remained after adjustment for patient characteristics (age, sex, ethnicity, and major comorbidities) and geographical region. There has been a substantial improvement in survival amongst people admitted to critical care with
coronavirus disease 2019 in England, with markedly higher survival rates in people admitted in May and June compared with those admitted in March and April. |
|
|
Derrick, KM, Mazori, et al |
Br J Dermatol |
Clinical data| Données cliniques |
This letter to the editor describes a 15‐year‐old female patient who presented with 2 weeks of a pruritic, hyperpigmented,
reticulated eruption on the trunk (a–c), polydipsia, polyuria, and unintentional 20‐lb weight loss. Skin biopsy was consistent with prurigo pigmentosa (PP). Laboratory investigations revealed new‐onset type 1 diabetes coincident with a positive test for SARS‐CoV‐2
IgG. This case raises the possibility that PP and new‐onset type 1 diabetes may be delayed manifestations of COVID‐19. |
|
|
Nowcasting COVID-19 incidence indicators during the Italian first outbreak |
Di Loro, Pierfrancesco Alaimo, Divino, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
A novel parametric regression model is proposed to fit incidence data typically collected during epidemics. The proposal
is motivated by real-time monitoring and short-term forecasting of the main epidemiological indicators within the first outbreak of COVID-19 in Italy. Accurate short-term predictions, including the potential effect of exogenous or external variables are provided;
this ensures to accurately predict important characteristics of the epidemic (e.g., peak time and height), allowing for a better allocation of health resources over time. Parameters estimation is carried out in a maximum likelihood framework. All computational
details required to reproduce the approach and replicate the results are provided. |
|
Personal consumption in the United States during the COVID-19 crisis |
Dong, D, Gozgor, et al |
Applied Economics |
Public Health response| Interventions de santé publique |
Using daily credit/debit card spending data for personal consumption expenditures for the period from 24 January 2020
to 10 June 2020, this paper shows that personal consumption expenditures in the United States have been significantly affected by the economic shocks in the COVID-19 era. The evidence is valid when we consider the data both at the national and state levels.
The evidence is also valid when we use the data for consumers at different income levels and consumption within different sectors. The only exception is consumption in grocery and food stores since the effect is dampened at the national level and in 31 of
51 states. |
|
dos Santos, RP, Şahin Bülbül, et al |
Acta Scientiae |
Public Health response| Interventions de santé publique |
This study investigated the impact of the increasing home and mobile Internet access on the existing educational inequalities.
Results suggest that the Brazilian school system is failing to cultivate in their students the more productive use of Internet access and therefore contributing to the widening of the existing second-level digital divide between regions and social classes.
This digital divide was critically exacerbated by the arrival of the ongoing COVID-19 pandemic and the suspension of present classes. |
|
|
Droste, MichaelC, Stock, et al |
medRxiv |
Economics | Économie |
We assess the economic value of screening testing programs as a policy response to the ongoing COVID-19 pandemic. We
find that the fiscal, macroeconomic, and health benefits of rapid SARS-CoV-2 screening testing programs far exceed their costs, with the ratio of economic benefits to costs typically in the range of 4-15 (depending on program details), not counting the monetized
value of lives saved. Unless the screening test is highly specific, however, the signal value of the screening test alone is low, leading to concerns about adherence. Confirmatory testing increases the net economic benefits of screening tests by reducing the
number of healthy workers in quarantine and by increasing adherence to quarantine measures. The analysis is undertaken using a behavioral SIR model for the United States with 5 age groups, 66 economic sectors, screening and diagnostic testing, and partial
adherence to instructions to quarantine or to isolate. |
|
|
A
nonlinear heuristic model for estimation of covid-19 impact to world population |
Ershkov, SV, Christianto, et al |
Romanian Reports in Physics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
we present a heuristic mathematical model for the outcome of outbreak, which differs from most of the existing theories
for describing of the evolution of the viruses in human society (mainly, from those which are based on dynamics by modelling with help of ordinary differential equations or well-known stochastic methods). By the way, during its spatial evolving, K-virus (Covid-19)
seems to be lost its mortal potential due to mutations. So, we hope its spreading will not be dangerous at the end of 1st year. For this reason, we do not think that eventually more than 35 millions will die from over the World |
|
ARIMA
models forecasting the SARS-COV-2 in the Islamic Republic of Iran |
Esmaeilzadeh, N, Shakeri, et al |
Asian Pacific Journal of Tropical Medicine |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This ARIMA model was used as a predictive tool for public health planning for better understanding of the dynamics
of COVID-19 in a resource-constrained context with |
|
Risk Factors for testing positive for SARS-CoV-2
in a national US healthcare system |
Fan, VS, Dominitz, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this observational study is to identify factors associated with positive SARS-CoV-2 PCR tests between March
1, 2020 and May 14, 2020. Of 88,747 persons tested, 10,131 (11.4%) were SARS-CoV-2 PCR positive. Positivity was associated with older age (≥80 vs. <50 years: aOR 2.16, 95% CI 1.97-2.37), male sex (aOR 1.45, 95% CI 1.34-1.57), regional SARS-CoV-2 burden (≥2,000
vs. <400 cases/million: aOR 5.43, 95% CI 4.97-5.93), urban residence (aOR 1.78, 95% CI 1.70-1.87), Black (aOR 2.15, 95% CI 2.05-2.26) or American Indian/Alaska Native/Pacific Islander (aOR 1.26, 95% CI 1.05-1.52) vs. White race, and Hispanic ethnicity (aOR
1.52, 95% CI 1.40-1.65). Obesity and diabetes were the only two medical conditions associated with testing positive. Documented fevers, chills, cough, and diarrhea were also associated with testing positive. The population attributable fraction of positive
tests was highest for regional SARS-CoV-2 burden (35.3%), followed by demographic variables (27.2%), symptoms (12.0%), obesity (10.5%), and diabetes (0.4%). Of 88,747 persons tested, 10,131 (11.4%) were SARS-CoV-2 PCR positive. Positivity was associated with
older age (≥80 vs. <50 years: aOR 2.16, 95% CI 1.97-2.37), male sex (aOR 1.45, 95% CI 1.34-1.57), regional SARS-CoV-2 burden (≥2,000 vs. <400 cases/million: aOR 5.43, 95% CI 4.97-5.93), urban residence (aOR 1.78, 95% CI 1.70-1.87), Black (aOR 2.15, 95% CI
2.05-2.26) or American Indian/Alaska Native/Pacific Islander (aOR 1.26, 95% CI 1.05-1.52) vs. White race, and Hispanic ethnicity (aOR 1.52, 95% CI 1.40-1.65). Obesity and diabetes were the only two medical conditions associated with testing positive. Documented
fevers, chills, cough, and diarrhea were also associated with testing positive. The population attributable fraction of positive tests was highest for regional SARS-CoV-2 burden (35.3%), followed by demographic variables (27.2%), symptoms (12.0%), obesity
(10.5%), and diabetes (0.4%). |
|
Ferraresi, M, Kotsogiannis, et al |
Econ Lett |
Public Health response| Interventions de santé publique |
Since COVID-19 was declared a pandemic, countries on the same pandemic trajectory have adopted very different lockdown
strategies. Using data for over 132 countries, and employing an event-study design, this paper identifies the role of political, economic and institutional factors in explaining the differential timing and intensity of stringency measures undertaken. |
|
|
Ferreras, Cristina, Pascual-Miguel, et al |
bioRxiv |
Therapeutics| Thérapeutique Immunology | Immunologie |
We report the existence of a SARS-CoV-2 specific T cell population within the CD45RA- T memory cells of the blood
from the convalescent donors. These cells can be easily, effectively, and rapidly isolated following a donor selection strategy based on the expression of IFN-g after exposure with SARS-CoV-2 specific peptides and HLA antigen expression. This way we can obtain
clinical-grade CD45RA- memory T lymphocytes from the blood of convalescent donors, biobanking, thawing, and using them as a treatment for moderate/severe cases of COVID-19. These so-called “living drugs” retain memory against SARS-CoV-2 and other pathogens
they have encountered previously. Unlike plasma where the concentration decreases after infusion, memory T cells expand and proliferate, so we hypothesize that will have a more lasting effect. |
|
|
Mental health of people in Australia in the first month of COVID-19
restrictions: a national survey |
Fisher, JR, Tran, et al |
Med J Aust |
Public Health response| Interventions de santé publique |
The objectives were to estimate the population prevalence of clinically significant symptoms of depression, generalised
anxiety, thoughts of being better off dead, irritability, and high optimism about the future, and of direct experience of COVID-19, loss of employment caused by COVID-19 restrictions, worry about contracting COVID-19, or major disadvantage because of the restrictions;
to examine the relationship between these experiences and reporting mental symptoms. An anonymous survey was sent to adult Australian residents from April 3, 2020 to May 2, 2020. A total of 13 829 respondents completed the survey. The estimated prevalence
of clinically significant symptoms of depression (PHQ-9 ≥ 10) was 27.6% (95% CI, 26.1-29.1%) and of clinically significant symptoms of anxiety (GAD-7 ≥ 10) 21.0% (95% CI, 19.6-22.4%); 14.6% of respondents (95% CI, 13.5-16.0%) reported thoughts of being better
off dead or self-harm (PHQ-9, item 9) on at least some days and 59.2% (95% CI, 57.6-60.7%) that they were more irritable (GAD-7, item 6). An estimated 28.3% of respondents (95% CI, 27.1-29.6%) reported great optimism about the future (score ≥ 8). People who
had lost jobs, were worried about contracting COVID-19, or for whom the restrictions had a highly adverse impact on daily life were more likely to report symptoms of depression or anxiety, and less likely to report high optimism than people without these experiences.
Mental health problems were widespread among Australians during the first month of the stage two COVID-19 restrictions; in addition, about one-quarter of respondents reported mild to moderate symptoms of depression or anxiety. |
|
Froidure, A, Mahieu, et al |
Aging (Albany NY) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The main risk factor for mortality of COVID-19 is older age, but outcome is very heterogeneous among individuals of
the same age group. Therefore, we hypothesized that telomere length (TL) influences COVID-19-related outcomes. In a prospective study, we measured TL by Flow-FISH in 70 hospitalized COVID-19 patients and compared TL distribution with our reference cohort of
491 healthy volunteers. We also correlated TL with baseline clinical and biological parameters. We stained autopsy lung tissue from six non-survivor COVID-19 patients to detect senescence-associated β-galactosidase activity, a marker of cellular aging. We
found a significantly higher proportion of patients with short telomeres (<10(th) percentile) in the COVID-19 patients as compared to the reference cohort (P<0.001). Short telomeres were associated with a higher risk of critical disease, defined as admission
to intensive care unit (ICU) or death without ICU. TL was negatively correlated with C-reactive protein and neutrophil-to-lymphocyte ratio. Finally, lung tissue from patients with very short telomeres exhibit signs of senescence in structural and immune cells.
Our results suggest that TL influences the severity of the disease. |
|
|
Diversity of ACE2 and its interaction with SARS-CoV-2
receptor binding domain |
Gan, JessieL, Huang, et al |
bioRxiv |
Coronavirology| Coronavirologie Animal model | Modèle animal |
We analyzed the binding surface of ACE2 from several important animal species to begin to understand the parameters
for the ACE2 recognition by the SARS-CoV-2 spike protein receptor binding domain (RBD). We employed Shannon entropy analysis to determine the variability of ACE2 across its sequence and particularly in its RBD interacting region, and assessed differences between
various species ACE2 and human ACE2. As cattle are a known reservoir for coronaviruses with previous human zoonotic transfer, and has a relatively divergent ACE2 sequence, we compared the binding kinetics of bovine and human ACE2 to SARS-CoV-2 RBD. This revealed
a nanomolar binding affinity for bovine ACE2 but an approximate ten-fold reduction of binding compared to human ACE2. |
|
Gąsior, M, Gierlotka, et al |
Kardiol Pol |
Healthcare Response | Réponse des soins de santé |
The aim of this retrospective study was to use population data or data from selected regions of Poland to confirm the
trend of a decrease in the number of patients treated for both ST-segment elevation myocardial infarction (STEMI) and non–ST-segment elevation myocardial infarction (NSTEMI) in the first weeks of the epidemic (before April 14, 2020). Data of the Polish National
Health Fund (Narodowy Fundusz Zdrowia [NFZ]) and State Emergency Medical Services (Państwowe Ratownictwo Medyczne [PRM]) as well as on administrative and epidemiological data, were used in the analysis. In the analyzed provinces, before April 26, 2020, 2599
infections were reported with the highest number in the Silesia Province, 1867 infections, and with 363 and 369 infections in the Opole and Podlasie Provinces, respectively. In all provinces, there was a decline in the number of PRM calls due to chest pain
by a mean of 11.7%. The number of AMI diagnoses made by the head of the PRM dropped by 22.3%. In the destination department, a similar percentage of patients with AMI were treated in 2019 and 2020. However, the total number of hospitalizations for AMI dropped
on average by 43.6%. The COVID-19 pandemic caused a significant reduction in the number of treated patients with myocardial infarction in Poland. |
|
|
Gavelli, F, Castello, et al |
Minerva Med |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The aim of the study was to evaluate the prognostic role of the Novara-COVID. We retrospectively collected data of
COVID patients admitted to our ED between March 16th and April 22nd, 2020. The Novara-COVID score was systematically applied to all COVID patients since its introduction in clinical practice and adopted to decide patients' destination. The ability of the Novara-COVID
score to predict in-hospital clinical stability and in-hospital mortality were evaluated through multivariable logistic regression and Cox Regression Hazard models, respectively. Among the 480 COVID patients admitted to the ED, 338 were hospitalized: the Novara-COVID
score was 0-1 in 49.7%, 2 in 24.6%, 3 in 15.4% and 4-5 in 10.3% of patients. Novara-COVID score values of 3 and 4-5 were associated with lower clinical stability with adjusted odds ratios of 0.28 0.13-0.59] and 0.03 0.01-0.12], respectively. When in-hospital
mortality was evaluated, a significant difference emerged between scores of 0-1 and 2 vs. 3 and 4-5. In particular, the death adjusted Hazard Ratio for Novara-COVID scores of 3 and 4-5 were 2.6 1.4-4.8] and 8.4 4.7-15.2], respectively. The Novara-COVID score
reliably predicts in-hospital clinical instability and mortality of COVID patients at ED presentation. This tool allows the Emergency Physician to detect patients at higher risk of clinical deterioration, suggesting a more aggressive therapeutic management
from the beginning. |
|
|
Unforeseen covid-19 on oncologic bone scan with spect/ct in a high prevalence
area |
Gill, SM, Hassan, et al |
Molecular Imaging and Radionuclide Therapy |
Clinical data| Données cliniques |
A 65-year-old woman with known diabetes and hypertension underwent a technetium methylene diphosphonate (Tc-99m MDP)
bone scan with single photon emission computed tomography/computed tomography (SPECT/CT) for shoulder pain. SPECT/CT showed MDP nonavid and scattered pulmonary ground-glass opacities bilaterally along with rounded nodular densities. Another 56-year-old patient
who was newly diagnosed with right breast invasive ductal carcinoma underwent a bone scan with SPECT/CT, which revealed bilateral pulmonary infiltrates. Both patients later tested positive for COVID-19. Therefore, nuclear physicians should be watchful of findings
related to COVID-19 on SPECT/CT thorax as this is becoming the new normal. |
|
Gniazdowski, V, Morris, et al |
Clin Infect Dis |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study aimed to quantify the association between positive COVID-19 molecular tests and infectious virus. In two
months, 29,686 specimens were tested and 2,194 patients received repeated testing. Virus recovery in cell culture was noted in specimens with SARS-CoV-2 target genes' Ct value average of 18.8 ± 3.4. Prolonged viral RNA shedding was associated with positive
virus growth in culture in specimens collected up to 20 days after the first positive result but mostly in individuals symptomatic at time of sample collection. Whole genome sequencing provided evidence the same virus was carried over time. Positive tests
following negative tests had Ct values higher than 29.5 and were not associated with virus culture. |
|
|
Perceived Stress in Primary School Children During the COVID-19 Outbreak |
Gokkaya, Berna, Kargul, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
This is the first study that was to assess the effect of the COVID-19 outbreak on perceived stress in primary school
children as measured through a Perceived Stress Scale in Children as user-friendly format. A moderate level of stress over the last month (Mean score 11.46±5.83; Range 0-26) was observed. Factors such as age, mother job, father job, confirmed/suspected cases
in family and knowledge of COVID-19 did not significantly affect PSS-C. High total perceived stress in female (ß= -0,148, P=0.011) were important related factors for PSS-C score in children. |
|
Gong, Yuanchao, Sun, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
The current longitudinal study made a preliminary exploration of the relationship between public risk perception of
the pandemic and climate change. The results show that pandemic risk perception has positive predictive effect on climate change concern mediated by negative emotions, but public attention to climate change is not impaired by increased concern for the pandemic. |
|
|
Severity of COVID-19 at elevated exposure to perfluorinated
alkylates |
Grandjean, Philippe, Timmermann, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Study of the effect of exposure to perfluorinated alkylate substances (PFASs) on COVID-19 severity. From Danish biobanks,
we obtained plasma samples from 323 subjects aged 30-70 years with known SARS-CoV-2 infection. The PFAS concentrations measured at the background exposures included five PFASs known to be immunotoxic. Plasma-PFAS concentrations were higher in males, in subjects
with Western European background, and tended to increase with age, but were not associated with the presence of chronic disease. Of the study population, 33%)had not been hospitalized, and of those hospitalized, 16% had been in ICU or were deceased. Among
the five PFASs considered, perfluorobutanoic acid (PFBA) showed an OR of 2.19 for increasing severity of disease, although the OR decreased to 1.77 after adjustment for age, sex, sampling site and interval between blood sampling and diagnosis. |
|
Coronavirus disease in a renal allograft recipient: A case report |
Gulati, Y, Prasad, et al |
Indian Journal of Transplantation |
Clinical data| Données cliniques |
A 57-year-old male kidney transplant recipient had a fever, headache, weakness, and positive severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection. |
|
Gündüç, S, Eryiğit, et al |
Physica A |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The scale of destruction of the most recent pandemic, COVID-19, has yet to be seen. This work aims to introduce intervention
methodology for the prevention of global scale spread of infectious diseases. The proposed method combines time-dependent infection spreading data with the social connectivity structure of the society. SIR model simulations provided the dynamic of contamination
spread in different sets of network data. |
|
|
Gusarov, S, Stoyanov, et al |
J Phys Chem Lett |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We propose novel descriptors based on a COSMO-RS (short for conductor-like screening model for real solvents) σ-profiles
for enhanced drug screening enabled by machine learning (ML). The descriptors' performance is hereby illustrated for nucleotide analogue drugs that inhibit the ribonucleic acid-dependent ribonucleic acid polymerase, key to viral transcription and genome replication.
The COSMO-RS-based descriptors account for both chemical reactivity and structure, and are more effective for ML-based screening than fingerprints based on molecular structure and simple physical/chemical properties. The descriptors are evaluated using principal
component analysis, an unsupervised ML technique. Our results correlate with the active monophosphate forms of the leading drug remdesivir and the prospective drug EIDD-2801 with nucleotides, followed by other promising drugs, and are superior to those from
molecular structure-based descriptors and molecular docking. The COSMO-RS-based descriptors could help accelerate drug discovery for the treatment of emerging diseases. |
|
|
H, KM, Brooks, et al |
Gynecol Oncol Rep |
Healthcare Response | Réponse des soins de santé |
While guidelines for oncology care delivery during the pandemic have been established, there is a paucity of data examining
patient experiences of cancer care during the COVID pandemic. This qualitative study captured the perspectives of women undergoing active treatment for gynecologic malignancy at an academic medical center. Hour-long semi-structured interviews were conducted
via video-conference and transcribed verbatim. Focused coding was conducted to identify all data related to COVID-19. These data were then categorized into themes that emerged inductively. Seven women (N = 7) were interviewed. Several themes arose under two
main categories: 1) Impact of COVID-19 on cancer care delivery and interactions and 2) Intersection of cancer and COVID-19 outside of the healthcare setting. Under category 1, themes included: going to treatment alone; variable access to care and information.
Under category 2, themes included: unavailability of cancer-specific social support; mask wearing; COVID-19 & life outlook; adapting coping strategies. Participants' perceptions of having cancer during the COVID-19 pandemic varied and were not always negative.
Healthcare systems can draw on our findings to inform interventions to ensure optimal patient care. |
|
|
Haddar, C, Verhoeven, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study aimed to compare five open one step RT-qPCR reagents to the SuperScript™ III Platinum™ One-Step qRT-PCR
kit (Invitrogen) considered as the reference one in France at the beginning of the pandemic for detection of SARS-CoV-2 in respiratory specimens by using a laboratory-developed assay targeting the viral RNA dependant RNA polymerase (RdRp) gene. The percentages
of concordance were all above 95 %. When comparing the CT values of the 48 extracts exhibiting CT values < 35 obtained with the reference reagent, the results were similar between the reagents although the differences of CT values were quite dispersed. All
five reagents can be considered as alternative reagents to the reference for detecting SARS-CoV-2 RNA. |
|
|
Haftom, M, Petrucka, et al |
Infection and Drug Resistance |
Public Health response| Interventions de santé publique |
The aim of this study was to determine knowledge, attitudes, and practices towards COVID-19 pandemic among quarantined
adults in Tigrai region, Ethiopia. Knowledge score was statistically significantly associated with gender, age, and educational status of the study participants, whereas attitude and practices were significantly associated with educational status and knowledge
of participants. |
|
|
Han, H, Lee, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique Economics | Économie |
Due to this tourism crisis, this research attempted to uncover the possible influence of the corporate social responsibility
efforts of the international tourism businesses and of the knowledge of COVID-19 on the US travelers’ decision formation for international tourism products. The findings revealed that corporate social responsibility improves travelers’ attitudes and behavioral
intentions. In addition, the travelers’ knowledge perception of COVID-19 was significantly associated with their psychological distress. Decreasing this psychological distress related to overseas tourism was of importance to boost a positive attitude toward
international traveling, which directly leads to increased behavioral intentions. Testing for the metric invariance revealed that an association between the corporate social responsibility and intentions was only significant when the travelers strongly felt
an ascription of responsibility for the COVID-19 outbreak and the pandemic. |
|
|
PMC7556807; Corona COVID-19 spread - a nonlinear
modeling and simulation |
Harb, AM, Harb, et al |
Comput Electr Eng |
Modelling/ prediction| Modélisation/prédiction Transmission |
This paper presents a non-linear model to simulate and predict the spreading of the newly discovered disease caused
by a new series of a Novel Coronavirus (COVID-19). The mathematical modeling in this study is based on the Susceptible Infected Recovery (SIR) model, where key controlling parameters are considered, namely: human contact factor b, transmit factor (a), health
medication factor (m) and initial infected (I0). The simulation results show the effect of these parameters, and their role in spreading the COVID-19. The results also show that by keeping a high medication factor and a low contact factor, the spreading of
COVID-19 will slow down. The medication health factor depends on the infrastructure of a country, and it is difficult to improve it instantly. On the other hand, the contact factor can be easily controlled. Enforcing the physical social distancing, drastically
decreases the contact factor. Hence, slow down the spreading of the virus. Also, the effect of medication factor on the number deaths caused by COVID-19 is studied. The results show that as medication factor increases the number of deaths decreases. |
|
Harley, K, Gunsolus, et al |
J Clin Microbiol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Three commercially available SARS-CoV-2 serologic assays with widespread distribution capabilities are compared. A
total of 667 specimens, 103 from patients with confirmed SARS-CoV-2 infections and 564 collected prior to the emergence of SARS-CoV-2, were analyzed in parallel using the Roche Elecsys SARS-CoV-2 Total Antibody and Abbott Alinity SARS-CoV-2 IgG assays; a subset
of 55 samples from patients with confirmed SARS-CoV-2 infections was additionally evaluated using the Abbott Architect SARS-CoV-2 IgM assay. Diagnostic sensitivities increased for all three assays with increasing time since the onset of symptoms. Among 51
patients with confirmed SARS-CoV-2 infections, 23 (45.1%), 24 (47.1%), and 22 (43.1%) were reactive by the Abbott IgG, Roche total antibody, and Abbott IgM assays, respectively, with sampling times 0-56 days post-positive PCR (median/mean 2/6.2 days). Combining
IgG and IgM screening identified 4/55 additional samples with detectable antibodies that would not have been observed using the assays independently. Notably, one immunocompromised patient with confirmed SARS-CoV-2 infection showed no detectable antibodies
using any of the three assays 43 days after onset of symptoms. |
|
|
Social Network Analysis for the Identification of Key Spreaders During COVID-19 |
Hasan, A, Kamal, et al |
Studies in Computational Intelligence |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this chapter, a method CovidKeySpreader has been proposed that integrates both local and global insight and adopts
a random walk algorithm to determine key spreaders in a patient interaction network related to India’s different states. For implementation, a state-wise network is constructed where nodes represent an individual patient and edges show interaction link between
them. Each node of the network is assigned to associated communities. Further, communities are analyzed by exploiting both node and community scores. Finally, a random walk algorithm is applied to the weighted network to iteratively rank nodes. The efficacy
of the proposed method is established using Susceptible-Infected-Recovered (SIR) spreading model and simulate the process of spreading on networks. Experiments conducted on four state-wise networks. The evaluation metric shows that the key spreaders identified
by our proposed algorithm are more significant in comparison to other basic centrality measures. |
|
Hedima, Erick Wesley, Michael, et al |
medRxiv |
Public Health response| Interventions de santé publique |
Objective: To assess the knowledge, preventive measures and risk perception of adult Nigerians regarding COVID-19 Methods:
online cross-sectional survey (n= 510). The questionnaire is divided in to four sections: 1) socio-demographic characteristics; 2) assessment of knowledge; 3) risk perception; and 4) preventive measures. Results: Of the 510 respondents, 95.9% claimed knowledge
of COVID-19, through the traditional media (55.3%), and social media (41%), while only 3.7% got informed through health officials. Level of education (P=0.0001), income status (P<0.00001) and being a healthcare worker (P=0.002) were significantly associated
with a good knowledge of COVID-19. Overall Risk perception was high (median score of 4 out of 5). Risk perception was significantly high among the female participants (P=0.04), young adult (P=0.039) and healthcare providers (P=0.001), while knowledge of preventive
measures like avoiding to eat outside the home (P=0.001), traveling to high risk areas (P=0.017), wearing face mask (P=0.01) and eating balanced diet (P=0.014) were significant across gender. |
|
|
Helle, Kristina Barbara, Sadiku, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We extend the simulation model underlying the pandemic preparedness web interface CovidSim 1.1 to study the hypothetical
effect of increased morbidity and mortality due to 'multi infections', either acquired by successive infective contacts during the course of one infection or by a single infective contact with a multi-infected individual. We study the hypothetical effects
of varying enhancements in morbidity and mortality, different likelihoods of multi-infected individuals to spread multi infections and different susceptibility to multi infectious in different disease phases. It is demonstrated that multi infections lead
to a slight reduction in the number of infections, as these are more likely to get isolated due to their higher morbidity. However, the latter substantially increases the number of deaths. Furthermore, simulations indicate that a potential second lockdown
can substantially decrease the epidemic peak, the number of multi-infections and deaths. |
|
|
Hennein, R, Lowe, et al |
PLoS One |
Healthcare Response | Réponse des soins de santé |
THis study aims to assess rates of probable major depression, generalized anxiety disorder, post-traumatic stress disorder,
and alcohol use disorder in health workers. In May 2020, an online survey was distributed to health workers across 25 medical centers throughout the United States. Of the 1,132 participants who completed the survey, 14.0% had probable major depression, 15.8%
probable generalized anxiety disorder, 23.1% probable post-traumatic stress disorder, and 42.6% probable alcohol use disorder. Our findings provide insights into novel factors that have impacted health workers' wellbeing during the COVID-19 pandemic. |
|
|
Iradukunda, PG, Pierre, et al |
J Community Health |
Public Health response| Interventions de santé publique |
This study underscores the need to enhance the knowledge, attitudes, and practice of people living with HIV (PLWH)
to protect this population against COVID-19. An institution-based cross-sectional study was conducted from August 31 to September 18, 2020 among 376 participants who were selected by a simple random sampling technique. A pretested and structured self-administered
questionnaire was used to collect data. Of the 376 participants, 363 (97%) obtained a high knowledge score, while more than a quarter of the participants (26%) had a poor attitude score, and the majority (90%) having a high practice score. Employment status
and duration on antiretroviral treatment (ART) were significantly associated with attitude scores (p = 0.004 and p = 0.013, respectively). Gender and duration on ART were significantly associated with practice scores (p = 0.02 and p = 0.012, respectively).
There was a moderate positive correlation (r = 0.57) between knowledge and attitude scores, and knowledge and practice scores (r = 0.55). There was a strong positive correlation (r = 0.67) between attitude scores and practice scores. Health education programs
tailored for PLWH and aimed at mobilizing and improving COVID-19-related knowledge, attitude, and practice should be prioritized in the Rwandan COVID-19 response. |
|
|
Mathematical modeling the epicenters of coronavirus disease-2019 (COVID-19) pandemic |
Jamshidi, B, Rezaei, et al |
Epidemiologic Methods |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper is an attempt to model epicenters mathematically. We present an algorithm to find new epicenters. Applying
our model for the data related to COVID-19 pandemic, we obtain epicenters in China, South Korea, Iran, Italy, France, Germany, Spain, the USA, and Switzerland, on the days 1, 35, 42, 42, 49, 50, 50, 50, and 56, respectively. Although the number of these epicenters
is less than 5% of all contaminated countries across the globe, as of March 22, 2020, they make up 74% of new cases and over 80% of total confirmed cases. Finally, we conclude that we expect to face three new epicenters between March 22 and April 1, 2020. |
|
Jani, VishalkumarJ, Mavalankar, et al |
medRxiv |
Epidemiology| Épidémiologie |
The paper aims to understand if different socioeconomic factors have a role to play in determining the intensity of
COVID-19 impact. Methods: The study uses a country-wise number of corona cases and deaths and analyse them in a cross-country multivariate regression framework. It uses gross domestic product per capita, average temperature, population density, and median
age as independent variables. The study uses testing data as a control variable. Results: In absence of the testing variable, higher-income countries have experienced a higher number of COVID cases. The population density, median age, climate do not have significant
impact. The countries with higher population density have lower deaths. Each region shows different patterns of correlation between socioeconomic factors and COVID intensity. |
|
|
Public perception of police behaviors in the disaster COVID-19 – The case of Serbia |
Janković, B, Cvetković, et al |
Policing |
Public Health response| Interventions de santé publique |
The aim of the study is to determine the perception of general public on the Serbian police behaviors in combating
COVID-19 pandemic, as well as the perception of the citizens how successful the police units were in fulfilling their tasks. Design/methodology/approach: Due to the state of emergency declared due to COVID-19 pandemic, in particular the restriction of movement
and the need for social distance, the data collection for this study had to be conducted via the online survey platform (Google.doc). The study was conducted during March–April 2020, only four weeks after the state of emergency was declared. Findings: Considering
the fact that police officers are not sufficiently prepared and trained to respond in these specific circumstances, it is necessary to improve their engagement in the future by conducting appropriate training, procuring adequate resources, implementing adequate
planning activities, etc. The results of the multivariate regressions of public perception preparedness subscale show that the most important predictor is gender and it explains 23.6% of the variance in preparedness subscale. The remaining variables did not
have significant effects on preparedness. |
|
Javaid, Amar, Swindin, et al |
Research Square prepub |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This article illustrates the response of Nottingham University Hospitals NHS Trust critical care department to the
COVID-19 crisis during the first pandemic wave. Patients admitted to critical care whom tested positive for SARS-CoV-2 between March-May 2020 were identified for retrospective case review as part of service evaluation. Clinical, laboratory and radiological
data was collected. A retrospective case review showed 109 patients admitted to critical care with COVID-19. 88 (80.7%) of the 109 patients received mechanical ventilation, 21 (19.3%) patients received renal replacement therapy. Critical care mortality was
26 (23.9%) patients and hospital mortality was 27 (24.8%) of the 109 patients. This mortality rate was an unexpected finding. |
|
|
Jin, Xiaoyong, Wang, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
COVID-19 pandemic has an unprecedented impact all over the world since early 2020. During this public health crisis,
reliable forecasting of the disease becomes critical for resource allocation and administrative planning. With more and more COVID-19 data becoming available, we observed that as COVID-19 spreads at different speed and scale in different geographic regions,
it is highly likely that similar progression patterns are shared among these regions within different time periods. This intuition lead us to develop a new neural forecasting model, called Attention Crossing Time Series (\textbf{ACTS}), that makes forecasts
via comparing patterns across time series obtained from multiple regions. |
|
|
Junqueira-Kipnis, A, Dos Anjos, et al |
Trials |
RCT |
A summary of a study protocol, recruitment in process for RCT of Vaccine. |
|
|
Mortality in Norway and Sweden Before and After the COVID-19
Outbreak |
Juul, Frederik Emil, Jodal, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Norway implemented extensive measures such as school closures and lock-downs, while Sweden has been criticised for
relaxed measures against Covid-19. We compared the effect of the different national strategies on all-cause and Covid-19 associated mortality. Covid-19 associated mortality rates were 0·2 per 100,000 (95% CI 0·1-0·4) in Norway and 2·9 (95% CI 1·9-3·9) in
Sweden. |
|
Kamal, AF, Widodo, et al |
Ann Med Surg (Lond) |
Healthcare Response | Réponse des soins de santé |
This study aims to investigate whether elective orthopaedic surgery will increase the risk of developing COVID-19.
This was a combined retrospective and prospective studies performed at a national tertiary hospital in Jakarta, Indonesia. Subjects were patients who underwent elective orthopaedic surgeries at our institution from April to May 2020. total of 35 subjects
(mean age 32.89 ± 17.42) were recruited. None of the patients developed symptoms suggestive of COVID-19 infection. We found that elective orthopaedic surgery may not be associated with increased cases of COVID-19 cases. However, our study was limited by short
duration of follow-up. |
|
|
Karami, Z, Knoop, et al |
Infect Dis (Lond) |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
This Study aimed to determine the incidence of bacterial co-infections, antibiotic use and application of antimicrobial
stewardship principles in hospitalized patients with COVID-19. A retrospective observational study in four hospitals (1 university, 2 non-university teaching, 1 non-teaching hospital) in the Netherlands from March to May 2020 including consecutive patients
with PCR-confirmed COVID-19 was preformed. Twelve (1.2%) of the 925 patients included had a documented bacterial co-infection (75.0% pneumonia) within the first week. On presentation 556 (60.1%; range 33.3-73.4%) patients received antibiotics for a median
duration of 2 days (IQR 1-4). Mean adherence to the local guideline on empiric antibiotic therapy on day 1 was on average 60.3% (range 45.3%-74.7%). On presentation to the hospital bacterial co-infections are rare, while empiric antibiotic use is abundant.
This implies that in patients with COVID-19 empiric antibiotic should be withheld. |
|
|
Keller, MD, Harris, et al |
Blood |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique Immunology | Immunologie |
In this report, we demonstrate that SARS-CoV-2-specific T-cells can be expanded from convalescent donors, and recognize
immunodominant viral epitopes in conserved regions of membrane, spike, and nucleocapsid. Following in vitro expansion using a GMP-compliant methodology (designed to allow the rapid translation of this novel SARS-CoV-2 T-cell therapy to the clinic), membrane,
spike, and nucleocapsid peptides elicited IFN-γ production, in 27 (59%), 12 (26%), and 10 (22%) convalescent donors (respectively), as well as in 2 of 15 unexposed controls. We identified multiple polyfunctional CD4-restricted T-cell epitopes within a highly
conserved region of membrane protein, which induced polyfunctional T cell responses, which may be critical for the development of effective vaccine and T cell therapies. Hence, our study shows that SARS-CoV-2 directed T-cell immunotherapy targeting structural
proteins, most importantly membrane protein, should be feasible for the prevention or early treatment of SARS-CoV-2 infection in immunocompromised patients with blood disorders or after bone marrow transplantation to achieve anti-viral control while mitigating
uncontrolled inflammation. |
|
|
PMC7543758; COVID-19 and the decline in Asian American employment |
Kim, AT, Kim, et al |
Res Soc Stratif Mobil |
Economics | Économie |
Thus study examines the negative effect of the lockdown on employment among Asian Americans. The empirical results
uncover that Asian Americans are more negatively affected by the lockdown than any other racial group, net of education, immigration status, and other covariates. Regardless of gender, less-educated Asian Americans are substantially more likely to lose employment
than equally educated Whites and are not more likely to regain employment during the reopening months. Other less-educated racial minorities do not experience more reduction in At-work status than Whites, net of covariates. |
|
Effectiveness of steroid treatment for SARS-CoV-2 pneumonia with COP-like reaction: a
case report |
Kim, T, Son, et al |
Disaster Med Public Health Prep |
Clinical data| Données cliniques |
We report a case of severe acute respiratory syndrome coronavirus-2 pneumonia manifesting as a cryptogenic organizing
pneumonia-like reaction and discuss its treatment, clinical course, and favorable outcomes after steroid administration. |
|
Lockdown related travel behavior undermines the containment
of SARS-CoV-2 |
Kishore, Nishant, Kahn, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Here, we measure the impact of the announcement and implementation of lockdowns on human mobility patterns by analyzing
aggregated mobility data from mobile phones. We find that following the announcement of lockdowns, both local and long distance movement increased. To examine how these behavioral responses to lockdown policies may contribute to epidemic spread, we developed
a simple agent-based spatial model. We find that travel surges following announcements of lockdowns can increase seeding of the epidemic in rural areas, undermining the goal of the lockdown of preventing disease spread. |
|
Kobayashi, T, Trannel, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We implemented serial COVID-19 testing for inpatients with a negative test on admission. The conversion rate (negative
to positive) on repeat testing was one percent. We identified patients during their incubation period and hospital-onset cases, rapidly isolated them, and potentially reduced exposures. Serial testing and infectiousness determination were resource intensive. |
|
|
Kokkoris, MD, Stavrova, et al |
Pers Individ Dif |
Public Health response| Interventions de santé publique |
In an online study (N = 271), we measured trait self-control, goal progress, continued engagement in pre-pandemic goal-directed
behaviors, development of new goal-directed behaviors and turning these new behaviors into habits. Results showed that during lockdown, people with higher (vs. lower) trait self-control were not only more likely to continue engaging in pre-pandemic goal-directed
behaviors, but also found it easier to develop new goal-directed behaviors and were more likely to turn these behaviors into habits. High self-control people's ability to continue performing pre-pandemic goal-directed behaviors and to turn new behaviors into
habits explained their success at goal attainment despite the major disruptions caused by the pandemic. |
|
|
Caring for COVID’s most vulnerable victims: a safety-net hospital responds |
Komaromy, Miriam, Harris, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
To respond to surge in people experiencing homelessness in pandemic Boston Medical Center opened decommissioned hospital.
Care was provided by physician volunteers and furloughed staff. This hospital-based COVID Recuperation Unit was rapidly deployed, provided safe isolation for 226 patients over 8 weeks, treated frequent SUD and mental illness, and helped prevent the hospital’s
acute-care bed capacity from being overwhelmed during the peak of the COVID-19 epidemic. |
|
Kubota-Koketsu, R, Terada, et al |
Transfusion |
Immunology | Immunologie |
The aim of this study was to determine whether normal intravenous immunoglobulin (N-IVIG) manufactured before the start
of the COVID-19 pandemic contained IgG antibodies against the circulating human coronaviruses (HCoVs) that cross-react with the highly pathogenic coronaviruses SARS-CoV-1, Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-2. The neutralizing
and binding activities of N-IVIG against SARS-CoV-1, MERS-CoV, SARS-CoV-2, HCoV 229E, and HCoV OC43 were evaluated. Nine N-IVIG lots manufactured between 2000 and 2018, derived from donors in Japan, were tested. None of the N-IVIG lots tested displayed neutralizing
or binding activity against SARS-CoV-1, MERS-CoV, or SARS-CoV-2. However, they displayed substantial neutralizing and binding activity against HCoV OC43 and weak neutralizing and substantial binding activity against HCoV 229E. |
|
|
Kumar, N, Sood, et al |
RSC Advances |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
This study employed an immunoinformatics framework to design a robust vaccine. The pathogenic sequence with cryptic
epitope taken from patients in Wuhan, China, was harnessed to design a promiscuous cytotoxic T-lymphocyte, helper T-lymphocyte, and B-cell epitope based subunit vaccine, engineered with adjuvants and conformational linkers. The reported vaccine has high antigenicity
and immunogenicity profiles with potential TAP affinity, which ensures elevated antigen processing capability. It has strong binding with major histocompatibility complex (MHC) receptors (MHC-1 and MHC-2) and virus-specific membrane receptor TLR-2, with scores
of -1010.7, -1035.7, and -1076.3 kcal mol-1, respectively. Molecular dynamics simulation analysis was used to assess the stable binding with TLR-2 with minimal atomic motions through a deformation plot, covariance matrix, and elastic network. And an in silico
immunization assay showed the reliable elicitation of key players in terms of immune cells together with memory cells to evoke adaptive immune responses upon administration of the construct. |
|
|
Non Linear Tensor Diffusion Based Unsharp Masking for Filtering of COVID-19 CT
Images |
Kumar, SN, Lenin Fred, et al |
Studies in Computational Intelligence |
Healthcare Response | Réponse des soins de santé |
This study proposes a novel filtering technique, Non Linear Tensor Diffusion based Unsharp Masking for CT images. The
performance validation was done by performance metrics like Just Noticeable Distortion (JND), Discrete Entropy (DE) and average mean brightness error (AMBE) for comparative analysis, classical filtering algorithms are used. The filtering algorithms are implemented
in Matlab2015b and tested on real time CT images of COVID-19. |
|
Forecasting the spread of COVID-19 pandemic in Bangladesh
using ARIMA model |
Kundu, Lakshmi Rani, Ferdous, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study aim to forecast the expected number of daily total confirmed cases, total confirmed new cases, total deaths
and total new deaths of COVID-19 in Bangladesh for Oct. 17 to Nov 15, 2020. Data from 8 March 2020 to 16 October, 2020 were collected to fit an Autoregressive Integrated Moving Average (ARIMA) model to forecast the spread of COVID-19 in Bangladesh. The results
showed an upward trend for the total confirmed cases and total deaths, while total confirmed new cases and total new death, will become stable if prevention measures are strictly followed to limit the spread of COVID-19. |
|
Lanzoni, Giacomo, Linetsky, et al |
SSRN- Lancet prepublication |
Therapeutics| Thérapeutique RCT |
The aim of this study was to determine safety and explore efficacy of Umbilical Cord (UC)-MSC infusions in COVID-19
ARDS. UC-MSC infusions in COVID-19 subjects with ARDS were safe and associated with fewer SAEs (severe adverse events), compared to control. Further, exploratory efficacy analyses provide preliminary evidence of reduction in mortality and time to recovery. |
|
|
Lee, CM, Cadigan, et al |
J Adolesc Health |
Public Health response| Interventions de santé publique |
PURPOSE: Young adults are at high risk for increases in loneliness and mental health problems during the COVID-19 pandemic.
The present study examined increases in loneliness in a young adult sample, for whom increases were greater, and association with increases in depression and anxiety. METHOD: Data from 564 young adults (ages 22-29, 60.7% women) were collected in January 2020
(pre-pandemic) and April/May 2020 (during pandemic). RESULTS: Loneliness increased from January to April/May and changes in loneliness were greater for females, those with higher perceived social support in January, and those with greater concerns about the
pandemic's social impacts. Depression (but not anxiety) increased during this time with changes in loneliness accounting for much of the increase in depression. CONCLUSIONS: Intervention strategies with young adults need to address loneliness and feelings
of reduced social support during this time, especially for those who may have had greater disruption in their social lives. |
|
|
Lelonek, M, Książczyk, et al |
Kardiol Pol |
Healthcare Response | Réponse des soins de santé |
This study aimed to obtain data on the care of patients with HF in Polish medical centers during the COVID-19 pandemic.
A survey was sent by email in June 2020 to most Polish medical centers that provide HF treatment. The number of hospitalizations due to HF in academic, provincial, or district centers was lower during the pandemic than earlier, while in regional centers somewhat
similar to that noted before the pandemic. A teleconsultation for new patients with HF as the only form of medical visit was provided in 33% of the centers. In 92% of the centers, e-prescriptions were issued. Following the national lockdown and social distancing
restrictions, a lower access to healthcare and highly specialized procedures in patients with HF and a decrease in the number of hospitalizations due to acute HF might have an impact on HF prognosis. |
|
|
Lack of association between ABO blood groups and susceptibility to SARS-CoV-2 infection |
Levi, JE, Telles, et al |
Vox Sang |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We sought to evaluate the relationship between blood group types and SARS‐CoV‐2 laboratory results from our database.
Among patients submitted to SARS‐CoV‐2 testing, we identified 6457 who had a concomitant ABO blood group typing result, being 4353 tested by RT‐PCR and 2275 for COVID‐19 antibodies, while 171 did both. Our data failed to reproduce the skewed frequency of ABO
blood group types previously reports. Though we do find a trend for a higher frequency of A and lower of O type comparing SARS‐CoV‐2 patients with the general population attended by the laboratory, these differences are quite small and did not reach statistical
significance. |
|
Li, A, Wang, et al |
Pers Individ Dif |
Public Health response| Interventions de santé publique |
This study investigated the relationship between self-compassion and life-satisfaction among Chinese self-quarantined
residents during the COVID-19 pandemic. Participants consist of 337 self-quarantined residents (129 men, 208 women) from a community in China. The results revealed that self-compassion was positively linked with life-satisfaction. Moreover, positive coping
partially mediated the relationship between self-compassion and life-satisfaction for males and not females. In the female group, self-compassion was positively linked with positive coping and life-satisfaction; however, positive coping and life-satisfaction
were not significantly linked. These findings indicated that intervention focus on self-compassion could increase life-satisfaction in self-quarantined people during the COVID-19. |
|
|
Exploring the N95 and Surgical Mask Supply in U.S. Nursing Homes During COVID-19 |
Li, Y, Fang, et al |
J Appl Gerontol |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
This project examined the factors that were associated with nursing homes' N95 and surgical mask supply. We analyzed
data from the Nursing Home COVID-19 Public File and conducted a multivariate logistic regression estimating the association between nursing home characteristics and county-level demographic parameters with mask supply. We found that a high number of resident
COVID-19 cases contributed to the supply of N95, but not surgical masks, whereas a high number of staff cases did not lead to an adequate supply of either N95 or surgical masks. Compared with not-for-profit (NFP) facilities, for-profit (FP) nursing homes were
less likely to get enough masks. |
|
Effects of space sizes on the dispersion of cough-generated droplets from a walking person |
Li, Zhaobin, Wang, et al |
arXiv |
Transmission |
The dispersion of viral droplets plays a key role in the transmission of COVID-19. In this work, we analyze the dispersion
of cough-generated droplets in the wake of a walking person for different space sizes. The air flow is simulated by solving the Reynolds-Averaged Navier-Stokes equations, and the droplets are modelled as passive Lagrangian particles. Simulation results show
that the cloud of droplets locates around and below the waist height of the manikin after two seconds from coughing, which indicates that kids walking behind an infectious patient are exposed to higher transmission risk than adults. More importantly, two distinct
droplet dispersion modes occupying significantly different contamination regions are discovered. A slight change of space size is found being able to trigger the transition of dispersion modes even though the flow patterns are still similar. This shows the
importance of accurately simulating the air flow in predicting the dispersion of viral droplets and implies the necessity to set different safe-distancing guidelines for different environments. |
|
Liu, L, Zheng, et al |
Int J Lab Hematol |
Clinical data| Données cliniques |
This study aimed to identify the critical predictors that can effectively assess the disease conditions of patients
with COVID-19 by analyzing the clinical characteristics and laboratory findings of patients with SARS-CoV-2 infection. All consecutive patients (n = 294) with confirmed SARS-CoV-2 infection admitted to the General Hospital of Central Theater Command of the
PLA from February 6 to February 21, 2020, were enrolled. The median neutrophil-to-lymphocyte ratio (NLR) value of the severe patients was dramatically higher than that of the nonsevere patients (10.4 vs 2.6; P .05). Neutrophil-to-lymphocyte ratio is a critical
predictor for assessment of disease severity in patients with COVID-19, and it has a close relation with the laboratory indicators related to disease conditions. |
|
|
Lobos, P, Lobos, et al |
JAAD Case Rep |
Clinical data| Données cliniques |
A 22-year-old healthy man presented with a 2-day history of an acute-onset petechial rash on his lower extremities.
He was strictly following government COVID-19 quarantine directions. A day before the petechial eruption, he reported gingival bleeding and a buccal hematoma occurring after a dental procedure. Suspecting a COVID-19–related acute platelet disarrangement, he
was immediately instructed to stop any physical activity, and a full laboratory workup was requested. Findings were in the normal ranges except for the platelet count which was severely decreased:1000/μL (reference range, 150,000-400,000/μL). An oropharyngeal
swab for SARS-Cov-2 testing was positive. He remained in good health, presenting only on the fifth day with a mild episode of headache, which resolved with acetaminophen. Laboratory findings showed a progressive increase in the platelet count (83,000/μL),
and the purpuric lesions began to disappear, so he was discharged on the sixth day. |
|
|
Loomba, Sahil, de Figueiredo, et al |
medRxiv |
Public Health response| Interventions de santé publique |
To help inform successful COVID-19 vaccination campaigns in the UK and US, we conducted a survey in the US and UK,
in Sept. 2020, to quantify how online misinformation impacts COVID-19 vaccine uptake intent and identify socio-economic groups that are most at-risk of non-vaccination and most susceptible to online misinformation. We show that recent misinformation around
a COVID-19 vaccine induces a fall in vaccination intent among those who would otherwise 'definitely' vaccinate by 6.4 percentages points in the UK and 2.4 in the US, with larger decreases found in intent to vaccinate to protect others. We find evidence that
socio-econo-demographic, political, and trust factors are associated with low intent to vaccinate and susceptibility to misinformation: notably, older age groups in the US are more susceptible to misinformation. We find evidence that scientific-sounding misinformation
relating to COVID-19 and vaccines COVID-19 vaccine misinformation lowers vaccination intent, while corresponding factual information does not. These findings reveal how recent COVID-19 misinformation can impact vaccination rates and suggest pathways to robust
messaging campaigns. |
|
|
Pathophysiology of multi-organ damage in SARS-CoV-2 infection |
López-Pérez, GT, de Lourdes Patricia Ramírez-Sandoval, et al |
Acta Pediatrica de Mexico |
Coronavirology| Coronavirologie |
Authors discuss how SARS-CoV-2 glycoprotein S binds to the host cell receptors of the enzyme, the conversion of angiotensin
2 (ACE2), which is a critical step for virus entry. Understanding the pathophysiology of SARS-CoV-2 infection is the cornerstone to provide timely diagnosis and implement appropriate treatment for patients, limiting the spread of the virus and ultimately
eliminating the presence of the virus in humanity. |
|
Lorenz, G, Moog, et al |
Sci Rep |
Clinical data| Données cliniques |
This study examines subgroups of Covid-19 patients; secondary hemophagocytic lymphohistiocytosis (sHLH) or cytokine
release syndrome (CRS) with features of macrophage activation syndrome to determin if these fators drive severe disease trajectories. 19 consecutive confirmed severe COVID-19-patients admitted to our intensive-care-unit were tested for presence of sHLH by
two independent experts. HScores and 2004-HLH diagnostic criteria were assessed. The median HScore at admission was 157 (IQR: 98;180), without the key clinical triad of HLH, i.e. progressive cytopenia, persistent fever and organomegaly. Independent expert
chart review revealed the absence of sHLH in all cases. No patient reached more than 3/6 of modified HLH 2004 criteria. Our study rules out virus induced sHLH as the leading cause of most severe-COVID-19 trajectories. |
|
|
Lou, LL, Xie, et al |
Chinese Journal of Contemporary Pediatrics |
Clinical data| Données cliniques Animal model | Modèle animal |
This research studied the expression of angiotensin-converting enzyme 2 (ACE2) and other key molecules of the RAS pathway
in normal mice at different developmental stages, and provided ideas for understanding the infection mechanism of coronavirus disease 2019 (COVID-19) as well as the diagnosis and treatment of children with COVID-19. The expression of ACE2 in the lungs showed
changes from embryonic stage to adult stage. It increased gradually after birth, reached a peak on day 3 after birth, and reached a nadir on day 14 after birth (P<0.05). The expression of AGT reached a peak on days 0 and 7 after birth and reached a nadir on
day 21 after birth (P<0.05). The expression of ACE increased rapidly after birth and reached a peak on day 21 after birth (P<0.05). Agtr1a expression reached a peak on day 21 after birth (P<0.05). Agtr2 expression gradually decreased to a low level after birth.
Renin, Agtr1b, and Mas1 showed low expression in lung tissues at all developmental stages. At different developmental stages of mice, ACE2 has dynamic expression changes, with high expression in early neonatal and adult mice. |
|
|
Outcomes of coronavirus disease 2019 in patients with neuromyelitis optica and associated
disorders |
Louapre, C, Maillart, et al |
Eur J Neurol |
Clinical data| Données cliniques |
Outcomes of coronavirus disease 2019 (COVID‐19) in patients with neuromyelitis optica spectrum disorders (NMOSD) or
myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), often treated with immunosuppressive therapies, are presented. |
|
Lü, M, Qiu, et al |
Aging (Albany NY) |
Transmission Clinical data| Données cliniques |
We performed single-cell transcriptomic analysis of placenta and other tissues from fetuses in comparison with those
from adults using public-available datasets. Our analysis revealed that a very small proportion of trophoblast cells expressed the Angiotensin I Converting Enzyme 2 (ACE2) gene, suggesting a low possibility of vertical transmission of SARS-CoV-2 from mother
to fetus during pregnancy. We found that the fetal adrenal gland, heart, kidney and stomach were susceptible to SARS-CoV-2 infection, because these organs contained cell clusters that expressed high levels of the ACE2 gene. In particular, a higher proportion
of ACE2-expressing cell clusters in the adrenal gland and kidney also expressed the Transmembrane Serine Protease 2 (TMPRSS2) gene compared with other organs. Surprisingly, ACE2-expressing type II alveolar (AT2) equivalent cells were absent in fetal lungs.
This is in sharp contrast to adult lungs. As ACE2 expression is regulated by various conditions, including oxygen concentration, inflammation and smoking, caution is warranted to avoid triggering potential ACE2 expression in fetal and placental tissue. |
|
|
Luo, Ruibang, Wong, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Motivation: Danchin et al. have pointed out that cytosine drives the evolution of SARS-CoV-2. A depletion of cytosine
might lead to the attenuation of SARS-CoV-2. Results: We built a website to track the composition change of mono-, di-, and tri-nucleotide of SARS- CoV-2 over time. The website downloads new strains available from GISAID and updates its results daily. Our
analysis suggests that the composition of cytosine in coronaviruses is related to their reported mortality. Using 137,315 SARS-CoV-2 strains collected in ten months, we observed cytosine depletion at a rate of about one cytosine loss per month from the whole
genome. Availability: The website is available at http://www.bio8.cs.hku.hk/sarscov2/.Competing Interest StatementThe authors have declared no competing interest. |
|
|
Lyu, X, Chen, et al |
|
Public Health response| Interventions de santé publique |
The aim of the authors was to analyze the sentiments and their evolution of people in the face of this public health
crisis based on Chinese Weibo, a largest social media platform in China. They developed a real-time visualization system to display the trend of the user’s sentiment and hot searched hashtags based on Weibo during the pandemic. |
|
|
Ma, Qianqian, Liu, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We consider several different models of epidemic spread over networks, including SIS/SIR/SEIR models as well as a new
model of COVID-19 transmissions with symptomatic and asymptomatic individuals. We provide two efficient algorithms which can efficiently compute the optimal lockdown, with one of our algorithms having a running time which explicitly scales only linearly in
the number of edges in the network and is applicable to the vast majority of epidemic models we have tested. We use publicly available data on inter-county travel frequencies to analyze a model of COVID-19 spread in the 62 counties of New York State; we compute
that an optimal stabilizing shutdown based on the state of the epidemic in April 2020 would have reduced activity more stringently outside of New York City compared to within it, even though the epidemic was much more prevalent in New York City at that point. |
|
|
Maher, JP, Hevel, et al |
Psychol Sport Exerc |
Public Health response| Interventions de santé publique |
Determine associations between physical activity (PA) and affect before and during COVID-19 stay-at-home orders and
how change in PA predicted change in affect during this time. Physical activity and positive affect decreased during the COVID-19 pandemic, Negative affect increased during the COVID-19 pandemic. Majority of participants experienced clinically meaningful levels
of stressful life events during the pandemic. Physical activity was associated with positive affect before and during the pandemic. |
|
|
A Case of a Newborn Baby Girl Infected with SARS-CoV-2 Due to Transplacental Viral Transmission |
Majachani, N, Francois, et al |
Am J Case Rep |
Transmission Clinical data| Données cliniques |
We present a case of neonatal SARS-CoV-2 likely due to transplacental transmission. CASE REPORT 31-year-old Hispanic
woman in the final week of pregnancy developed mild respiratory symptoms of COVID-19 pneumonia and tested positive for SARS-CoV-2 infection. She had a history of Human immunodeficiency virus (HIV) infection and gestational diabetes. Two days later, she gave
birth to a baby girl who tested positive for SARS-CoV-2 on the first day after birth. She was delivered via elective cesarean section adhering to a strict infection control protocol. |
|
Mak, JonathanKL, Kuja-Halkola, et al |
medRxiv |
Epidemiology| Épidémiologie |
Using data from the UK Biobank, we assessed whether frailty and comorbidity predict COVID-19 mortality in the overall
community population (n=437,555) and in a selected COVID-19 positive sample (n=2,059). Frailty was assessed using the Rockwood Frailty Index (FI) and the Hospital Frailty Risk Score (HFRS). Comorbidity was assessed by the Charlson Comorbidity Index (CCI).
Overall, 408 individuals died of COVID-19. In the full sample, HFRS (OR 1.07) and CCI (OR 1.14) were associated with increased risk of COVID-19 mortality, while FI was not statistically significantly different from null in the multivariable logistic regression
model. Adding HFRS or CCI to a model with only age and sex resulted in significantly larger areas under the receiver operating characteristic curves. Nevertheless, when restricting the analyses to COVID-19 positive cases, neither of the frailty measures or
CCI added meaningful predictive accuracy on top of age and sex. Besides, we observed stronger associations between HFRS categories and COVID-19 mortality in relatively younger (<75 years) than older individuals (≥75 years). |
|
|
Mallongi, A |
Medico-Legal Update |
Epidemiology| Épidémiologie |
The method in this research is a qualitative method with a case study approach model. The approach model focuses on
gathering various information from several sources such as documents, field surveys, observations, interviews, and detailed recordings. Data collection was carried out based on the number of cases infected in 3 major cities of Indonesia (Jakarta, Surabaya
and Makassar).The results showed COVID-19 cases in Jakarta, Surabaya and Makassar continued to experience an increase in cases every day. As of March 3-April 19, 2020 confirmed 3033 cases in Jakarta, in Makassar City as many as 453 confirmed cases from March
3-April 25 2020. In Surabaya City there were 392 confirmed cases from March 23-April 28, 2020. Increasing the number of positive cases, in three big cities Makassar, Surabaya and Jakarta because there are still many people who do not follow government regulations
related to social distancing. The COVID-19 transmission pathways are breathing and contact, therefore proper use of PPE will be able to prevent the transmission of Cov-2 SARS. |
|
|
Lockdown Measures and Air Quality: Evidence
from Italian Provinces |
Malpede, Maurizio, Percoco, et al |
SSRN- Lancet prepublication |
Public health interventions*| Interventions de santé publique |
The aim of this short communication is to estimate the effects of the implementation of more restrictive lockdown measures
on pollution levels in Italy. Using a time series of weekly concentrations of PM 10 , PM 2.5 and NO 2 for the period 2016–2020 across 71 provinces, we find that the introduction of lockdown measures reduced the air concentration levels of PM 10 and NO 2 by
17–18%, while their effect on PM 2.5 remains unclear. These results indicate that the lockdown yielded a double dividend in terms of lives saved and improved air quality. |
|
Malsy, J, Veletzky, et al |
Clin Infect Dis |
Clinical data| Données cliniques |
Provide detailed clinical, virological and immunological data of a B-cell depleted patient treated with obinutuzumab
for follicular lymphoma with protracted COVID-19 and viremia. A sustained response was achieved after two courses of remdesivir and subsequent convalescent plasma therapy. Immunocompromised patients might require combined and prolonged antiviral treatment
regimens |
|
|
Mao, X, Yang, et al |
J Nurs Manag |
Healthcare Response | Réponse des soins de santé |
The study reports on the actions and incident management of the advanced practice nurses of a disaster operation team
who were deployed in response to the COVID‐19 outbreak. The response teams of advanced practice nurses in the study clearly demonstrated their competencies in disaster rescue, which fulfilled most of the core competencies set forth by the International Council
of Nurses. |
|
|
Masud, MA, Islam, et al |
Mathematics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this study, the authors consider the case of Bangladesh, and fit a simple compartmental model holding a feature
to distinguish between identified infected and infectious with time series data using least square fitting as well as the likelihood approach. The performance of the likelihood approach was found to be more promising . The study demonstrates that the parameters
defining the infectious and quarantine rates change with time as a consequence of the change in lock-down strategies and expansion of testing facilities. And the value of the basic reproduction number R0 was shown to be between 1.5 and 12. The analysis reveals
that the projected time and amplitude of the peak vary following the change in infectious and quarantine rates obtained through different lock-down strategies and expansion of testing facilities. The identification rate determines whether the observed peak
shows the true prevalence. Found that by restricting the spread through quick identification and quarantine, or by implementing lock-down to reduce overall contact rate, the peak could be delayed, and the amplitude of the peak could be reduced. This study
could also infer the unidentified COVID cases besides estimating the officially confirmed COVID cases. |
|
|
An ultra-sensitive, ultra-fast whole blood monocyte
CD169 assay for COVID-19 screening |
Michel, Moise, Malergue, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Monocyte CD169 upregulation has been reported as a marker of viral infections, we evaluated a flow cytometry three-color
rapid assay of whole blood monocyte CD169 for CoVID-19 screening. Outpatients (n=177) with confirmed CoVID-19 infection, comprising 80 early-stage, 71 late-stage, and 26 asymptomatic patients received whole blood CD169 testing in parallel with SARS-CoV-2 RT-PCR.
Upregulation of monocyte CD169 without polymorphonuclear neutrophil CD64 changes was the primary endpoint. Sensitivity was 98% and 100% in early-stage and asymptomatic patients respectively, specificity was 50% and 84%. Rapid whole blood monocyte CD169 evaluation
was highly sensitive when compared with RT-PCR, especially in early-stage, asymptomatic patients whose RT-PCR tests were not yet positive. |
|
Minten, B, Mohammed, et al |
European Journal of Development Research |
Public Health response| Interventions de santé publique |
To understand transformation processes in this commercial cluster and the disruption to the cluster caused by the COVID-19
crisis, two rounds of surveys were implemented. In the first round done in late January and in February 2020, 810 farmers were interviewed. The second-round survey done in May 2020 was a phone survey, in which we sought to understand the impact of the COVID-19
crisis on these vegetable farmers. The majority of farmers indicated that they have avoided hiring workers and going to labor markets to hire workers. They have also avoided going to agro-dealers out of fear of getting infected and have reduced their contacts
with extension agents, other farmers, and traders. To assess the impacts of COVID-19 disruptions on their vegetable production activities, we asked qualitative questions on the effects on access to inputs and services, access to labor markets, output market
functioning, and plans for the future. We note that all factor prices have significantly increased over the three-month period, this suggests that production cost increases for vegetable production have been substantial since the start of the COVID-19 pandemic. |
|
|
Impact of immunosuppression on mortality in critically ill COVID-19 patients |
Mirouse, A, Darmon, et al |
Br J Haematol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In a prospective single‐centre cohort of 100 critically ill COVID‐19 patients 26 were immunocompromised. Day‐28 mortality
was 29% overall, 20.5% in non‐immunocompromised patients and 50% in immunocompromised patients. By multivariable analysis, age, immunocompromised status, and Sequential Organ Failure Assessment (SOFA3) at day 1 per quartile were associated with day‐28 mortality.
After matching 26 immunocompromised patients to 26 non‐immunocompromised patients based on age, comorbidities, body mass index, and SOFA, immunocompromised status was not associated with day‐28 mortality |
|
Misra, Pratibha, Mukherjee, et al |
medRxiv |
Clinical data| Données cliniques |
The study aimed to quantify promoter methylation of ACE2 and TMPRSS2 along with its mRNA expression in saliva samples
of COVID-19 patients in order to understand the regulatory mechanism of these genes in SARS-CoV-2 infection. Saliva samples were collected from thirty male patients with SARS-CoV-2 infection and thirty age-matched healthy control male subjects. Q MS PCR and
qRT PCR was performed to quantify the promoter DNA methylation and mRNA expression of ACE2 and TMPRSS2 respectively. The study did not find any significant difference between methylation and expression of these two genes in cases compared to control subjects.
However there was significant positive correlation between DNA methylation of ACE2 and its gene expression. Among cases, the sample collected ≥ 7 days after appearance of symptoms showed higher amount of methylation in both ACE2 and TMPRSS2 genes when compared
to sample collected before 7 days. |
|
|
SARS-CoV-2 Transmission in Educational Settings During an Early
Summer Epidemic Wave in Luxembourg |
Mossong, Joël, Mombaerts, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Transmission Public Health response| Interventions de santé
publique |
We compared the incidence in school-age children, teachers and the general working population in Luxembourg, and estimated
the number of secondary transmissions occurring at schools using contact tracing data. Based on a total of 424 reported confirmed COVID-19 cases in school-age children and teachers, we estimate that 179 index cases caused 49 secondary transmissions in schools.
While some small clusters of mainly student-to-student transmission within the same class were identified, we did not observe any large outbreaks with multiple generations of infection. Precautionary measures including physical distancing as well as easy access
to testing, systematic contact tracing appears to have been successful in mitigating transmission within educational settings. |
|
Interpreting Uncertainty in Model Predictions For COVID-19 Diagnosis |
Murugamoorthy, Gayathiri, Khan, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
There have been several works so far in predicting COVID positive cases with chest X-Rays. However, not much has been
explored on quantifying the uncertainty of these predictions, interpreting uncertainty, and decomposing this to model or data uncertainty. To address these needs, we develop a visualization framework to address interpretability of uncertainty and its components,
with uncertainty in predictions computed with a Bayesian Convolutional Neural Network. This framework aims to understand the contribution of individual features in the Chest-X-Ray images to predictive uncertainty. Providing this as an assistive tool can help
the radiologist understand why the model came up with a prediction and whether the regions of interest captured by the model for the specific prediction are of significance in diagnosis. |
|
Mutlu, E, Anıl Yağcıoğlu, et al |
Eur Arch Psychiatry Clin Neurosci |
Public Health response| Interventions de santé publique |
Our CMHC had been closed between 23 March and 13 April 2020 because the team was initially assigned to Etimesgut State
Hospital for the outbreak until mid-April. Once reopened, telepsychiatry monitoring at CMHC was initiated once/twice a week or biweekly according to the patient’s clinical status. From a number of total 188 patients, 155 could be contacted. The relapse rate
of the patients in the first trimester of COVID-19 outbreak was 11% (bipolar disorder n = 2, schizophrenia n = 15). Most of the patients who experienced relapse reported discontinuation of antipsychotics (59%). In addition, 2 patients were hospitalized, 4
were admitted to the ER, 2 had new onset of suicidal thoughts/suicide attempt, and 3 showed self-harm or violent behavior. |
|
|
Nascimento, BR, Brant, et al |
J Telemed Telecare |
Healthcare Response | Réponse des soins de santé |
Assess the impact of a large-scale COVID-19 telemedicine system on emergency department (ED) visits and all-cause and
cardiovascular hospital admissions in Brazil. Telemedicine resulted in low rates of ED visits and hospital admissions, suggesting positive impacts on healthcare utilization. Cardiovascular admissions were remarkably rare. |
|
|
Naser, AY, Al-Hadithi, et al |
Int J Soc Psychiatry |
Public Health response| Interventions de santé publique |
Evaluate the effects of social distancing on the social relationships of the Jordanian population. |
|
|
Delayed acute myocarditis and COVID-19-related multisystem inflammatory syndrome |
Nicol, M, Cacoub, et al |
ESC Heart Fail |
Clinical data| Données cliniques |
We describe clinical presentation and diagnostic workup of acute myocarditis in a patient who had developed COVID-19
syndrome 1 month earlier. A healthy 40-year-old man suffered from typical COVID-19 symptoms. Four weeks later, he was admitted because of fever and tonsillitis. Blood tests showed major inflammation. Thoracic computed tomography was normal, and RT-PCR for
SARS-CoV-2 on nasopharyngeal swab was negative. Because of haemodynamic worsening with both an increase in cardiac troponin and B-type natriuretic peptide levels and normal electrocardiogram, acute myocarditis was suspected. Cardiac echographic examination
showed left ventricular ejection fraction at 45%. Exhaustive diagnostic workup included RT-PCR and serologies for infectious agents and autoimmune blood tests as well as cardiac magnetic resonance imaging and endomyocardial biopsies. Cardiac magnetic resonance
with T2 mapping sequences showed evidence of myocardial inflammation and focal lateral subepicardial late gadolinium enhancement. Pathological analysis exhibited interstitial oedema, small foci of necrosis, and infiltrates composed of plasmocytes, T-lymphocytes,
and mainly CD163(+) macrophages. These findings led to the diagnosis of acute lympho-plasmo-histiocytic myocarditis. There was no evidence of viral RNA within myocardium. The only positive viral serology was for SARS-CoV-2. The patient and his cardiac function
recovered in the next few days without use of anti-inflammatory or antiviral drugs. |
|
Nie, D, Shen, et al |
Atmos Res |
Public health interventions*| Interventions de santé publique Economics | Économie |
Conducted a timely investigation on the changes of air quality, associated health burden and economic loss during the
COVID-19 pandemic in China. |
|
|
Nishimura, Yoshito, Ochi, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
This study aimed to provide details on how medical students had been affected by the pandemic, and in relation to the
nation-wide state of emergency (SOE). In this cross-sectional study, 473 medical students participated in the web-based survey. Among the findings, 29.8% reported concerns about the shift toward online education; participant's subjective mental health status
significantly worsened after the SOE was lifted; those who had concerns about a shift toward online education had higher odds of having generalized anxiety and being depressed (OR 1.97), as did those who requested food aid and mental health care resources
(OR 1.99 and OR 3.56 respectively). |
|
|
Nitschke, JP, Forbes, et al |
Br J Health Psychol |
Public Health response| Interventions de santé publique |
Examined the relationship between individuals’ levels of social connectedness during lockdown and self‐reported stress,
worry, and fatigue. Results demonstrate that greater social connectedness during the lockdown period was associated with lower levels of perceived stress and general and COVID‐19‐specific worries. Found a negative relationship between fatigue and social connectedness,
which was mediated by feelings of stress, general worries, and COVID‐19‐specific worries—respectively, indicating that individuals with smaller network sizes, who were highly distressed during the pandemic, were also likely to report feeling more fatigued |
|
|
O'Brien, CM, Jung, et al |
Journal of the American College of Radiology |
Healthcare Response | Réponse des soins de santé |
This study determined differences in the types of presenting illnesses, severity, and rate of resultant surgical intervention
during the pandemic. In all, 733 patients were included in the 2019 cohort, and 422 patients were included in the 2020 cohort. In 2019, 32.7% had positive CT findings, increasing to 50.5% in 2020. The number of complications increased from 7.9% to 19.7%. The
rate requiring surgical intervention increased from 26.3% to 47.6% in 2020. |
|
|
Ogidigo, JO, Iwuchukwu, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Herein, we identified potent phytocompounds from two antiviral plants Momordica charantia L. and Azadirachta indica
used locally for the treatment of viral and parasitic infections. Structure-based virtual screening and molecular dynamics (MD) simulation have been employed to study their inhibitory potential against the main protease (M(pro)) SARS-CoV-2. A total of 86 compounds
from M. charantia L. and A. indica were identified. The top six phytocompounds; momordicine, deacetylnimninene, margolonone, momordiciode F2, nimbandiol, 17-hydroxyazadiradione were examined and when compared with three FDA reference drugs (remdesivir, hydroxychloroquine
and ribavirin). The top six ranked compounds and FDA drugs were then subjected to MD simulation and pharmacokinetic studies. These phytocompounds showed strong and stable interactions with the active site amino acid residues of SARS-CoV-2 Mpro similar to the
reference compound. Results obtained from this study showed that momordicine and momordiciode F2 exhibited good inhibition potential (best MMGBA-binding energies; -41.1 and -43.4 kcal/mol) against the M(pro) of SARS-CoV-2 when compared with FDA reference anti-viral
drugs (Ribavirin, remdesivir and hydroxychloroquine). Per-residue analysis, root mean square deviation and solvent-accessible surface area revealed that compounds interacted with key amino acid residues at the active site of the enzyme and showed good system
stability. The results obtained in this study show that these phytocompounds could emerge as promising therapeutic inhibitors for the M(pro) of SARS-CoV-2. |
|
|
Pachar L, , JV, et al |
Revista Espanola de Medicina Legal |
Clinical data| Données cliniques |
We share the findings of the microscopic study of lung samples from a COVID-19 positive patient who died unexpectedly
at home in quarantine. Our observations confirm endothelialitis, thrombosis and angiogenesis as microscopic hallmarks of the lung pathology of this new disease. These findings have clinical and therapeutic implications. |
|
|
Pandey, HC, Coshic, et al |
Vox Sang |
Healthcare Response | Réponse des soins de santé |
The present study had tried to understand the impact of SARS-CoV-2 pandemic on blood collection and demand as well
as the impact of disaster planning in maintaining an adequate inventory. Data related to blood supply and demand were collected retrospectively using blood bank management software for pre-COVID-19 and COVID-19 time period and compared. Strategies adopted
and effects of changes in existing disaster plans to maintain an adequate inventory were studied. A drastic fall in the red cell inventory was observed as compared to pre-COVID-19 time period was observed due to disproportionate decrease in blood collection
(1/6 to 1/9 of the previous collection) and demand (1/2 of the previous demand). The buffer stock fell gradually over a period of three weeks with cancellation of planned blood donation drives. A buffer stock equivalent to 2-week inventory led to adequate
inventory in the initial lockdown periods. Similar fall was observed in the platelet inventory with reduction in the blood collection but almost a proportionate reduction in the platelet demand led to adequate inventory. No increase in wastage was observed
for both red cells and platelets during this period. |
|
|
Park, C, Hwang, et al |
J Korean Med Sci |
Healthcare Response | Réponse des soins de santé |
In this cross-sectional study conducted from April 2 to 10, 2020, university hospital workers were administered self-reported
questionnaires that covered general characteristics and included the Patient Health Questionnaire, Generalized Anxiety Disorder scale, and a visual analog scale. At-risk groups for depression and anxiety were identified, and the odds ratios for depression
and anxiety were analyzed after adjusting for age, gender, education, marital status, and duration of employment. The COVID-19 outbreak is correlated with healthcare workers' emotional stress, and specific types of jobs and duties involving close contact with
these patients can be risk factors. Even low-exposure groups reported significant depression and anxiety as a result of social stigma and uncertainty. |
|
|
Computational Intelligence Approach for Prediction of COVID-19 Using Particle
Swarm Optimization |
Patibandla, RSML, Narayana, et al |
Studies in Computational Intelligence |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Computational Intelligence methods are effectively utilized in various real-life applications during a diversity of
commercial and medical problems. This study introduced a standard rule detection process reinforced swarm intelligence to advert the eminence creation of rules and smear the rule pruning appliance to condense the rule. The predictable technique usages COVID-19
and Mammographic Corpus Statistics. This procedure, while smeared on COVID-19, initiate to be extra precise associated with the prevailing Classification procedures explicitly Classification using Decision Trees. This performance analysis has been achieved
with slightly more balanced trees using entropy-based Information gain measures. |
|
Characteristics associated with household transmission
of SARS-CoV-2 in Ontario, Canada |
Paul, LaurenA, Daneman, et al |
medRxiv |
Epidemiology| Épidémiologie Transmission |
This study aimed to identify characteristics associated with higher household transmission of SARS-CoV-2. Using address
matching, a cohort was assembled of all laboratory-confirmed cases of COVID-19 residing in private households in Ontario. Descriptive analyses were performed to compare characteristics of cases in households that experienced secondary transmission versus those
that did not. Logistic regression models were fit to determine index case characteristics and neighbourhood characteristics associated with transmission. Between January and July, 2020, there were 26,152 cases of COVID-19 residing in 21,226 households. Longer
testing delays (≥5 days versus 0 days OR=3.02) and male sex (OR=1.28) were associated with greater odds of household secondary transmission, while being a healthcare worker (OR=0.56) was associated with lower odds of transmission. Neighbourhoods with larger
average economic family size and a higher proportion of households with multiple persons per room were also associated with greater odds of transmission. |
|
Pavan Kumar, Nathella, Padmapriyadarsini, et al |
medRxiv |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
Authors investigated the impact of BCG vaccination on the frequencies of T cell, B cell, monocyte and dendritic cell
subsets as well as total antibody levels in a group of healthy elderly individuals (age 60-80 years) at one month post vaccination as part of their clinical study to examine the effect of BCG on COVID-19. BCG vaccination was associated with enhanced innate
and adaptive memory cell subsets, as well as total antibody levels in elderly individuals, suggesting its potential utility in SARS-Cov2 infection by enhancing heterologous immunity. |
|
|
Pedersen, OB, Nissen, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Immunology | Immunologie |
We assessed SARS-CoV-2 seroprevalence among retired blood donors and combined it with national COVID-19 survey data
to provide reliable population-based infection fatality rate (IFR) estimates for the age group 70 years and older. Of the 60926 identified retired blood donors age 70 years or older in the rosters of three region-wide Danish blood banks, 24861 responded to
a questionnaire on COVID-19 symptoms. Randomly selected, 1,201 (37.5%) individuals were tested for SARS-CoV-2 antibodies (Wantai) and compared to 1,110 active blood donors age 17-69 years. Among retired (age 70 years or older) and active (age 17-69 years)
blood donors, adjusted seroprevalences were 1.4% (95% CI: 0.3%-2.5%) and 2.5% (95% CI: 1.3%-3.8%), respectively. Using available population data on COVID-19 related fatalities, IFRs for patients age 70 years or older and for 17-69 years were estimated at 5.4%
(95% CI: 2.7%-6.4%) and 0.083% (95% CI: 0.054%-0.18%), respectively. Only 52.4% of SARS-CoV-2 seropositive retired blood donors reported having been sick since the start of the pandemic. |
|
|
Perisetti, Abhilash, Goyal, et al |
SSRN- Lancet prepublication |
Healthcare Response | Réponse des soins de santé |
In this study the data about the rates of utilization of endoscopy and outcomes among patients with upper gastrointestinal
bleeding from January 1, 2020, to September 1, 2020, from the TriNetX multicenter research network database, were analyzed. In hospitalized adult COVID-19 patients endoscopy utilization was associated with a significantly lower risk of mortality (37%) and
acute respiratory distress syndrome (61%). |
|
|
Plante, JA, Liu, et al |
Nature |
Coronavirology| Coronavirologie Immunology | Immunologie |
D614G, SARS-CoV-2 spike protein mutation enhances replication on human lung epithelial cells and primary human airway
tissues through an improved infectivity of virions. Hamsters infected with the G614 variant produced higher infectious titers in the nasal washes and trachea, but not lungs, confirming clinical evidence that the D614G mutation enhances viral loads in the upper
respiratory tract of COVID-19 patients and may increases transmission. |
|
|
Porto, Luis Cristovao, Costa, et al |
medRxiv |
Clinical data| Données cliniques |
This study aimed to identify the symptoms associated with early-stage COVID-19 infections in healthcare professionals
(HCP) using both clinical and laboratory data. Anosmia/hyposmia (p 9%) were common among patients with a confirmed COVID-19 diagnosis. |
|
|
Quadros, CA, Leal, et al |
Expert Rev Med Devices |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
Aerosolized markers were successfully contained within a novel isolation system for aerosol transmitted infections
in all experimental simulations, offering occupational and environmental protection against the dissemination of aerosolized microparticles under some medical procedures or therapy conditions indicated for patients with acute respiratory infections. |
|
|
Qutob, Nouar, Salah, et al |
bioRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Authors report the first SARS-CoV-2 genomes from Palestine sampled from early March, when the first cases were observed,
through to August of 2020. The work highlights the value of ongoing genomic surveillance and monitoring to reconstruct the epidemiology of COVID-19 at both local and global scales. |
|
|
Rahmani, Abolfazl, Baee, et al |
Research Square prepub |
Vaccine Research| Recherche sur les vaccins Immunology | Immunologie |
To construct a trivalent subunit vaccine against SARS, MERS and COVID-19, CTL, HTL, MHC I, and IFN-γ epitopes were
predicted. To stimulate strong helper T lymphocytes (HTLs) responses, Pan HLA DR-binding epitope (PADRE) was used. For boosting immune response, β-defensin 2 was added to the construct as an adjuvant. Based on the predicted epitopes, a trivalent multi-epitope
vaccine with a molecular weight of 74.8 kDa as a strong antigen, a non-allergenic, and soluble protein was constructed. The predicted epitopes demonstrated strong potential to stimulate T and B-cell mediated immune responses. Furthermore, codon optimization
and in silico cloning guaranteed increased expression. |
|
|
Raitio, A, Ahonen, et al |
Scand J Surg |
Healthcare Response | Réponse des soins de santé |
A great decrease in the need of trauma operations related to fractures, appendicitis, and acute scrotum in children
was observed during the peak of COVID-19 pandemic in Finland. |
|
|
Rajan, Shiv, Tripathi, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique Economics | Économie |
A cross-sectional survey was conducted from June 9, 2020, to July 29, 2020, using a self-designed questionnaire on
310 cancer patients planned for surgery. The maximum impact in the access to health care was seen in patients of age group 31-50 years, those coming from rural areas, daily wagers, patients with annual income INR <35K, and those with education below secondary
school. |
|
|
Ramirez-Sandoval, J, Gaytan-Arocha, et al |
Blood Purif |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Describe the tolerability and security of prolonged intermittent renal replacement therapy (PIRRT) in COVID-19 patients
with acute respiratory distress syndrome (ARDS) who required mechanical ventilation and developed severe acute kidney injury (AKI), a Mexican hospital sample. PIRRT was found to be feasible in the majority of COVID-19 patients with ARDS and severe AKI, despite
frequent transitory intradialytic hypotensive episodes. PIRRT may represent an acceptable alternative of renal replacement therapy during the COVID-19 outbreak. |
|
|
Ramos-Rincon, J, Buonaiuto, et al |
J Gerontol A Biol Sci Med Sci |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Conducted a nationwide, multicenter, retrospective, observational study in patients ≥80 years hospitalized with COVID-19
in 150 Spanish hospitals. The cohort of very old inpatients with COVID-19 shows that age, male sex, and poor pre-admission functional status—not comorbidities—are independently associated with in-hospital mortality. Severe COVID-19 at admission is related
to poor prognosis. |
|
|
Pediatric Teleneuropsychology: Feasibility and Recommendations |
Ransom, DM, Butt, et al |
Arch Clin Neuropsychol |
Healthcare Response | Réponse des soins de santé |
Aimed to demonstrate the feasibility of Teleneuropsychology (TeleNP) during the COVID pandemic in a pediatric clinical
population and disseminate clinical decision-making procedures to guide best practices. TeleNP was an accessible option for most patients and families, with no differences in demographic variables in patient appointment attendance, whether testing was conducted,
and whether the patient was referred for face-to-face follow-up. Patients using laptops/desktops were more likely to undergo remote test administration in comparison with patients using phones/tablets (χ2 = 23.83, p < .002). Sixty-three percent of the sample
were referred for a face-to-face follow-up assessment. |
|
Rebello, CM, Fascina, et al |
Pediatr Res |
Transmission Clinical data| Données cliniques |
We report the first newborn in whom SARS-CoV-2 was isolated from umbilical cord blood and two samples of a skin swab
by real-time polymerase chain reaction (RT-PCR) immediately after birth, suggesting the occurrence of vertical transmission. |
|
|
Reji Kumar, K |
Studies in Computational Intelligence |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This research studied the situation in Kerala after the outbreak of COVOD-19 and analyzed the effect of the control
strategies. The main focus is on a comparative study of the predictions of the SIR model and the actual performance made by the state in controlling the disease. |
|
|
Rivera, Javier, Castrejón, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
The objective of this prospective study was to determine whether severity of FM increases because of confinement due
to the COVID-19 pandemic through two questionnaires. A total of 93 patients received a phone consultation, (95.5% females), mean (SD) age of 48.23 (8.38) years. Following confinement, 25 (49%) patients got worse (group worse) and 26 (51%) patients experienced
no change or improved (group stable). Passive coping was significantly different in group worse in pre-confinement evaluation. The perceived worsening among FM patients relies primarily on how patients cope with their disease, without a real impact on clinical
manifestations. |
|
|
Impact of the COVID-19 pandemic on obstructive sleep apnea: recommendations for symptom
management |
Rizzo, D, Libman, et al |
J Clin Sleep Med |
Healthcare Response | Réponse des soins de santé |
we address the following important questions: (1) How can patients be identified for possible obstructive sleep apnea
(OSA) while sleep clinic testing is temporarily unavailable or limited? and (2) What measures can be suggested to improve sleep health until proper diagnosis and treatment become safe and available again? Our findings suggest that family practitioners can
effectively pre-screen patients for possible OSA by inquiring about 5 items that form the SSC Sleep Disorders subscale. If OSA is suspected, there are a range of behavioral techniques which we recommend to improve symptoms. |
|
Characteristics of Pediatric Inflammatory Multisystem Syndrome Associated
with COVID-19 |
Rosenberg, K |
Am J Nurs |
Clinical data| Données cliniques |
According to this study the pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory
syndrome coronavirus 2 has a wide range of presenting signs and symptoms and disease severity; and this syndrome appears to differ from other inflammatory disorders seen in children. |
|
Rosenfeld, Ronit, Noy-Porat, et al |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
Authors characterized and further evaluated the recently identified human monoclonal MD65 antibody for its ability
to provide protection against a lethal SARS-CoV-2 infection of K18-hACE2 transgenic mice. The data unprecedentedly demonstrate, the therapeutic value of human monoclonal antibodies as a life-saving treatment of severe COVID-19 infection. |
|
|
Phase 3 Trial of Coronavir (Favipiravir) in Patients with Mild to Moderate COVID-19 |
Ruzhentsova, Tatiana, Chukhliaev, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The aim of this study was to evaluate the efficacy and safety of favipiravir for treatment of mild to moderate coronavirus
disease (COVID-19). The statistically significant difference in the median time to viral clearance was observed only in the hospitalized cohort of patients: 3·0 (IQR 3·0; 3·0) vs. 5·0 (IQR 4·5; 5·5), respectively (HR 2·11; 95% CI 1·04-4·31; p = 0·038). |
|
Sagaon-Teyssier, L, Kamissoko, et al |
Health Policy Open |
Healthcare Response | Réponse des soins de santé |
This study aimed to identify individual and structural factors associated with mental health disorders (MHD) in the
NGO’s healthcare workers (HCW) in the early stage of the COVID-19 outbreak. Symptoms of depression, anxiety and insomnia were declared by 71.9, 73.3, and 77% participants, respectively. Women were at greater risk of MHD. A lack of personal protection equipment
and human resources, especially nurses, was associated with a high risk of MHD. |
|
|
Clinical characteristics of Severe Acute Respiratory
Syndrome by COVID-19 in Indigenous of Brazil |
Sardinha, Daniele Melo, Lima, et al |
medRxiv |
Clinical data| Données cliniques |
The objective of this study is to investigate the clinical characteristics of severe acute respiratory syndrome by
COVID-19 in indigenous peoples of Brazil. The public and health policies of Brazil should be directed to control the dissemination of COVID-19 in this population, that COVID-19 evolves in the same intensity, however, the indigenous have vulnerabilities that
can enhance the impact of the pandemic in this population. |
|
Scarpazza, Cristina, Musumeci, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
To avoid the spreading of the virus, mathematical models predicting the course of infection spread1 become the basis
to plan stringent countermeasures. This study results suggest that human beings are not passive victims, but active fighters able to change the course of the infection creating adaptive strategies against the infection spread. |
|
|
A theoretical analysis of the putative ORF10 protein
in SARS-CoV-2 |
Schuster, Noah Avery |
bioRxiv |
Coronavirology| Coronavirologie |
This study uses multiple bioinformatic programs to theoretically characterize and construct the ORF10 protein in SARS-CoV-2.
This study does present theoretical examinations that can serve as platforms to drive additional experimental work that assess the biological relevance of this hypothetical protein in SARS-CoV-2. |
|
Seow, J, Graham, et al |
Nat Microbiol |
Clinical data| Données cliniques Immunology | Immunologie |
Using sequential serum samples collected up to 94 d post onset of symptoms (POS) from 65 individuals with real-time
quantitative PCR-confirmed SARS-CoV-2 infection, we show seroconversion (immunoglobulin (Ig)M, IgA, IgG) in >95% of cases and neutralizing antibody responses when sampled beyond 8 d POS. We show that the kinetics of the neutralizing antibody response is typical
of an acute viral infection, with declining neutralizing antibody titres observed after an initial peak, and that the magnitude of this peak is dependent on disease severity. |
|
|
Chronic pain in the time of COVID-19: Stress aftermath and central sensitization |
Serrano-Ibáñez, ER, Esteve, et al |
Br J Health Psychol |
Public Health response| Interventions de santé publique |
This study investigated the contribution of life changes due to the coronavirus to emotional distress in individuals
with a diagnosis of chronic central sensitization pain and tested whether the associations between level of pain and sensitization were independent of or mediated by emotional distress. Due to the COVID‐19 situation, individuals with central sensitization
pain syndromes may be at higher risk of developing psychological distress. Interdisciplinary interventions involving psychologists are urgently needed. |
|
PMC7567668; Dynamics of respiratory droplets carrying SARS-CoV-2 virus in closed
atmosphere |
Shadloo-Jahromi, A, Bavi, et al |
Results Phys |
Modelling/ prediction| Modélisation/prédiction Transmission |
In this study, the vertical traveling of a wide range (100 nm-10 μm) of representative carrier droplets is studied
in three ambient temperatures of 258, 298, and 318 K using all-atom molecular dynamics simulation. Our obtained results confirm that by increasing the room temperature, the suspending time of aerosol (suspended droplets carrying virus particles) increases
due to the higher dynamics of air and evaporated water molecules in room space. In fact, by increasing the indoor temperature, the collision rate of aerosol and ambient atmosphere molecules increases significantly. Our result shows this higher rate of collision
could have a dual effect on the lifetime of aerosol considering the fact of faster deposition of larger (heavier) droplet due to the gravitational force. On one hand, in higher temperatures, the higher collision can split the droplets to smaller ones with
a semi-permanent suspension period. On the other hand, the higher dynamics of ambient molecules can lead to meet and coalesce of smaller cough/sneeze droplets making larger (heavier) droplets with faster sediment times. So, the role of indoor humidity to fuel
the probability of coalescence phenomenon and lifetime of droplets becomes more determinant in the warmer spaces. |
|
Modeling the Impact of Delaying Bariatric Surgery due to COVID-19: a Decision Analysis |
Shipe, ME, Beeghly-Fadiel, et al |
Obes Surg |
Healthcare Response | Réponse des soins de santé |
We developed a decision analysis model to evaluate risks and benefits of delaying scheduled bariatric surgery during
the novel coronavirus disease (COVID-19) pandemic. Our base case was a 45-year-old female with diabetes and a body mass index of 45 kg/m2. We compared immediate with delayed surgery after 6 months to allow for COVID-19 prevalence to decrease. We found that
immediate and delayed bariatric surgeries after 6 months resulted in similar 20-year overall survival. When the probability of COVID-19 infection exceeded 4%, then delayed surgery improved survival. |
|
Projection de la demande de lits de soins intensifs durant l’épidémie de COVID-19 au
Canada |
Shoukat, A, Wells, et al |
Cmaj |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We designed an agent-based model integrating age, and parameterized it according to the age structure of each province
and the first estimates of the characteristics of COVID-19. In our scenario an.alyzes, we considered voluntary isolation of mild cases as a control measure and assessed its effect on the epidemic curve and intensive care needs. Then we did simulations by assigning
the average number of secondary cases, also called the basic reproduction rate ( R 0 ), the value of 2 and 2.5. or each province, we stratified the population into 5 age groups - 0–4 years, 5–19 years, 20–49 years, 50–64 years and ≥ 65 years - using data from
the last census of Canada. The number of intensive care beds in the provinces varies between 0.63 and 1.85 per 10,000 inhabitants. Assuming an occupancy rate of 80%, we calculated that the number of beds available to treat patients with COVID-19 varied between
0.13 and 0.37 per 10,000 population. The average number of additional beds needed would then be 31 per 10,000 inhabitants, or 24.4% less than in the absence of voluntary isolation. |
|
Singh, PK, Pathania, et al |
SAR QSAR Environ Res |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study the authors have attempted to utilize the remdesivir-RdRp complex - RdRp (RNA-dependent RNA polymerase)
being the putative target for remdesivir - to screen a library of the already reported RdRp inhibitor database. Further clustering on the basis of structural features and scoring refinement was performed to filter out false positive hits. Finally, molecular
dynamics simulation was carried out to validate the identification of hits as RdRp inhibitors against novel coronavirus 2019-nCoV. The results yielded two putative hits which can inhibit RdRp with better potency than remdesivir, subject to further biological
evaluation. |
|
|
Singh, S, Foster, et al |
Am J Case Rep |
Clinical data| Données cliniques |
In this report, we present the case of a young patient in New York City who presented to our hospital with coronavirus
disease 2019-induced diabetic ketoacidosis (DKA) that progressed to ARDS and subsequent death. |
|
|
Staub, MB, Beaulieu, et al |
Infect Control Hosp Epidemiol |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We evaluate changes in antimicrobial use (AU) during COVID-19 and after implementation of a multispecialty COVID-19
clinical guidance team compared to pre-COVID-19 AU. In the initial COVID-19 period, compared to the pre-COVID-19 period, IM and MICU teams increased weekly AU by 145.3 [95% CI 35.1 to 255.5] and 204.0 [95% CI -16.9 to 424.8] DOT, respectively compared to non
COVID-19 teams. AU initially increased for COVID-19 patient care teams compared to pre-COVID-19 levels, but significantly decreased after implementation of a multispecialty clinical guidance team, which may be an effective strategy to reduce unnecessary AU. |
|
|
Steinhauer, Katrin, Meister, et al |
bioRxiv |
Therapeutics| Thérapeutique |
In this study antiseptic mouthwashes based on the actives chlorhexidine (CHX) and octenidine (OCT) were investigated
regarding their efficacy against SARS-CoV-2. The OCT-based formulation was effective within only 15 seconds against SARS-CoV-2, and thus constitutes an interesting candidate for future clinical studies to prove its effectiveness in a potential prevention of
SARS-CoV-2 transmission by aerosols. |
|
|
Strauss, AT, Boyarsky, et al |
Am J Transplant |
Healthcare Response | Réponse des soins de santé |
COVID‐19 has profoundly affected the American health care system; its effect on the liver transplant (LT) waitlist
based on COVID‐19 incidence has not been characterized. Using SRTR data, we compared observed LT waitlist registrations, waitlist mortality, deceased donor LTs (DDLT), and living donor LTs (LDLT) 3/15/2020‐8/31/2020 to expected values based on historical trends
1/2016‐1/2020, stratified by statewide COVID‐19 incidence. Overall, from 3/15‐4/30 new listings were 11% fewer than expected (IRR=0.84 0.89 0.93), LDLTs were 49% fewer (IRR=0.37 0.51 0.72), and DDLTs were 9% fewer (IRR=0.85 0.91 0.97). In May, new listings
were 21% fewer (IRR=0.74 0.79 0.84), LDLTs were 42% fewer (IRR=0.39 0.58 0.85) and DDLTs were 13% more (IRR=1.07 1.15 1.23). Centers in states with the highest incidence 3/15‐4/30 had 59% more waitlist deaths (IRR=1.09 1.59 2.32) and 34% fewer DDLTs (IRR=0.50
0.66 0.86). By August, waitlist outcomes were occurring at expected rates, except for DDLT (13% more across all incidences). While the early COVID‐affected states endured major transplant practice changes, later in the pandemic the newly COVID‐affected areas
were not impacted to the same extent. |
|
|
Sulisworo, D, Fitrianawati, et al |
Data Brief |
Public Health response| Interventions de santé publique |
This article presents data that explore the profiles of self-regulated learning in 1st-grade to 12th-grade students.
The sample consisted of 6571 students. The questionnaire was distributed to 61 schools (37 primary schools, 12 junior high schools, and 12 senior high schools) with an online survey in Yogyakarta, Indonesia. |
|
|
Sümen, A, Adibelli, et al |
Perspect Psychiatr Care |
Public Health response| Interventions de santé publique |
Regarding the coronavirus outbreak, it was found that 84.9% of the participants are afraid/anxious. Domestic violence
cases have increased due to the outbreak. The coronavirus outbreak causes fear and anxiety in society. This triggers so many psychological symptoms. |
|
|
Thomas, T, Stefanoni, et al |
J Proteome Res |
Clinical data| Données cliniques |
The present study combines state-of-the-art metabolomics, proteomics, and lipidomics approaches to investigate the
impact of COVID-19 on RBCs from 23 healthy subjects and 29 molecularly diagnosed COVID-19 patients. RBCs from COVID-19 patients had increased levels of glycolytic intermediates, accompanied by oxidation and fragmentation of ankyrin, spectrin beta, and the
N-terminal cytosolic domain of band 3 (AE1). Significantly altered lipid metabolism was also observed, in particular, short- and medium-chain saturated fatty acids, acyl-carnitines, and sphingolipids. Nonetheless, there were no alterations of clinical hematological
parameters, such as RBC count, hematocrit, or mean corpuscular hemoglobin concentration, with only minor increases in mean corpuscular volume. Taken together, these results suggest a significant impact of SARS-CoV-2 infection on RBC structural membrane homeostasis
at the protein and lipid levels. Increases in RBC glycolytic metabolites are consistent with a theoretically improved capacity of hemoglobin to off-load oxygen as a function of allosteric modulation by high-energy phosphate compounds, perhaps to counteract
COVID-19-induced hypoxia. Conversely, because the N-terminus of AE1 stabilizes deoxyhemoglobin and finely tunes oxygen off-loading and metabolic rewiring toward the hexose monophosphate shunt, RBCs from COVID-19 patients may be less capable of responding to
environmental variations in hemoglobin oxygen saturation/oxidant stress when traveling from the lungs to peripheral capillaries and vice versa. |
|
|
PMC7441972; Acute limb ischemia as sole initial manifestation of SARS-CoV-2 infection |
Thompson, O, Pierce, et al |
J Vasc Surg Cases Innov Tech |
Clinical data| Données cliniques |
We present the case of a patient with acute upper limb ischemia as the sole initial manifestation of severe acute respiratory
syndrome associated with coronavirus disease 2 infection, without concomitant respiratory symptoms or pneumonia. Viral infection presumably precipitated the patient's thromboembolic event, causing multifocal vascular occlusions. This case illustrates that
coronavirus disease-19 must be considered in the differential diagnosis of patients presenting with signs or symptoms of coagulopathy, even in the absence of respiratory symptoms. We believe that an awareness of the variety of clinical presentations in patients
with coronavirus disease-19, particularly extrapulmonary manifestations, is critical for optimal patient management as well as implementation of appropriate infection prevention measures. |
|
Tracewski, P, Ludwikowska, et al |
Kardiol Pol |
Clinical data| Données cliniques |
On May 3, 2020, a 2-year-old boy in good condition, with no significant medical history, was admitted to our hospital
on the 10th day of fever (body temperature of up to 40 °C) after ineffective oral empiric antibiotic therapy with amoxicillin with clavulanic acid. The polymerase chain reaction (PCR) nasopharyngeal swab test for severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) yielded negative results twice. The result of the Anti-SARS-CoV-2 ELISA test (Euroimmun, Lübeck, Germany) was positive for immunoglobulin G, and negative for immunoglobulin M. Kawasaki disease–specific treatment was administered. |
|
|
Trovato, CM, Montuori, et al |
Eur J Gastroenterol Hepatol |
Healthcare Response | Réponse des soins de santé |
Because elective pediatric endoscopy has been substantially shouted down during COVID-19, many children remained undiagnosed
– and therefore untreated – for celiac disease for a long time. We aimed to analyze the feasibility and accuracy of a biopsy-free approach in suspected celiac disease children with TGA-IgA values <10 ULN to facilitate the diagnostic process by avoiding endoscopy.
During the COVID-19 outbreak, a temporarily reduction of the TGA-IgA threshold for biopsy-sparing approach seems feasible in EMA positive children with TGA-IgA between 5 and 10 ULN. |
|
|
Ugolini, F, Massetti, et al |
Urban For Urban Green |
Public Health response| Interventions de santé publique |
This study aims to identify the drivers that normally attract visitors to Urban green space (UGS), and to assess the
effects of social isolation on the usage and perception of UGS during the COVID-19 pandemic. Results showed that urban residents normally have a need for accessible UGS, mainly for physical exercise, relaxing and observing nature. The reduction in UGS visitation
during the containment period was related to distinct changes in the motivations of those who did visit, with a relative increase in "necessary activities" such as taking the dog out, and a reduction in activities that could be considered non-essential or
high-risk such as meeting people or observing nature. Behavioral changes related to proximity were also observed, with an increase in people walking to small urban gardens nearby (e.g. in Italy) or tree-lined streets (e.g. in Spain, Israel), and people traveling
by car to green areas outside the city (e.g. in Lithuania). What the respondents missed the most about UGS during the pandemic was "spending time outdoors" and "meeting other people" – highlighting that during the COVID-19 isolation, UGS was important for
providing places of solace and respite, and for allowing exercise and relaxation. Respondents expressed the need for urban greenery even when legally mandated access was limited |
|
|
Ul-Rahman, A, Shabbir, et al |
Mol Biol Rep |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie zoonoses |
We conducted an in silico analysis of all the coding gene sequences of SARS-CoV-2 strains (n = 39) originating from
a range of non-human mammalian species, including pangolin, bat, dog, cat, tiger, mink, mouse, and the environmental samples such as wastewater, air and surface samples from the door handle and seafood market. Compared to the reference SARS-CoV-2 strain (MN908947;
Wuhan-Hu-1), phylogenetic and comparative residue analysis revealed the circulation of three variants, including hCoV-19 virus from humans and two hCoV-19-related precursors from bats and pangolins. A lack of obvious differences as well as a maximum genetic
homology among dog-, cat-, tiger-, mink-, mouse-, bat- and pangolin-derived SARS-CoV-2 sequences suggested a likely evolution of these strains from a common ancestor. Several residue substitutions were observed in the receptor-binding domain (RBD) of the spike
protein, concluding a promiscuous nature of the virus for host species where genomic alternations may be required for the adaptation to novel host/s. However, such speculation needs in vitro investigations to unleash the influence of substitutions towards
species-jump and disease pathogenesis. |
|
|
Uyaroğlu, OA, Başaran, et al |
Int J Qual Health Care |
Clinical data| Données cliniques |
In this study, we aimed to find out the 30-day readmission rate of mild and moderate severity COVID-19 patients discharged
from a tertiary care university hospital. From March 26 to May 1, there were 154 mild or moderate severity (non-critical) COVID-19 patients discharged from COVID-19 wards, of which 11 (7.1%) were readmitted. Malignancy (18.7% vs 2.1%, P = 0.04) and hypertension
(45.5% vs 14%, P = 0.02) were more common in those who were readmitted. |
|
|
Clinical impact of COVID-19 on people with substance use disorders |
Vallecillo, G, Perelló, et al |
J Public Health (Oxf) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The study aimed to describe the clinical characteristics and outcomes of COVID-19 on people with substance use disorders.
Among 2078 patients admitted, 27 (1.3%) were people with substance use disorders: 23(85.2%) were men with a median age of 56.1 + 10.3 years and. The main SUD were alcohol in 18(66.7%) patients, heroine in 6(22.2%) and cocaine in 3(11.1%) and 24(88.8%) patients
were on ongoing substance use disorder treatment. During a median length of stay of 10 days (IQR:7-19), severe pneumonia developed in 7(25.9%) patients, acute respiratory distress syndrome in 5 (18.5%) and none died. |
|
van Walraven, C, Manuel, et al |
J Gen Intern Med |
Modelling/ prediction| Modélisation/prédiction Transmission |
Derived and assessed a model to predict risk of SARS-CoV-2 in community-based people. A total of 9172 consecutive people
were studied. Overall infection rate was 6.2% but this varied during the study period. SARS-CoV-2 infection likelihood was primarily influenced by contact with a COVID-19 case, fever symptoms, and recent case detection rates. Internal validation found that
the SARS-CoV-2 Risk Prediction Score (SCRiPS) performed well with good discrimination (c-statistic 0.736) and very good calibration (integrated calibration index 0.0083). Focusing testing on people whose expected SARS-CoV-2 risk equaled or exceeded the recent
case detection rate would increase the number of identified SARS-CoV-2 cases by 63.1% (95%CI 54.5-72.3). |
|
|
Varghese, C, Xu, et al |
Infect Dis Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
The Australian and New Zealand governments both initiated strict social distancing measures in response to the COVID-19
pandemic in late March. It remains difficult to quantify the impact this had in reducing the spread of the virus. Our models predict these strict social distancing measures caused a 79% and 61% reduction in the daily cases of COVID-19 across Australia and
New Zealand respectively. |
|
|
Diagnostic value of cutaneous manifestation of SARS-CoV-2
infection |
Visconti, Alessia, Bataille, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The aim of this study was to assess the diagnostic value of new skin rashes in SARS-CoV-2 infection. Skin rashes cluster
with other COVID-19 symptoms, are predictive of a positive swab test and occur in a significant number of cases, either alone or before other symptoms. |
|
Wang, GY, Tang, et al |
Infect Dis Poverty |
Public Health response| Interventions de santé publique |
The present study aims to investigate the perceived psychosocial health and its sociodemographic correlates among Chinese
community-dwelling residents during the COVID-19 pandemic. More than one-third of the participants reported worsening in the experience of hopelessness and loneliness, with more than two-fifth of worsening depression during the pandemic compared with before
the outbreak. Several socioeconomic and lifestyle factors were found to be associated with the outcome variables, most notably participants' marital status, household income, smoking, alcohol drinking, existing chronic conditions. |
|
|
Wang, Hongping, Li, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Transmission |
Coronavirus disease 2019 (COVID-19) has become a global pandemic infectious respiratory disease with high mortality
and infectiousness. This paper investigates respiratory droplet transmission, which is critical to understanding, modeling and controlling epidemics. In the present work, we implemented flow visualization, particle image velocimetry (PIV) and particle shadow
tracking velocimetry (PSTV) to measure the velocity of the airflow and droplets involved in coughing and then constructed a physical model considering the evaporation effect to predict the motion of droplets under different weather conditions. The experimental
results indicate that the convection velocity of cough airflow presents the relationship t−0.7 with time; hence, the distance from the cougher increases by t0.3 in the range of our measurement domain. Substituting these experimental results into the physical
model reveals that the small droplets (initial diameter D≤ 100 μm) evaporate to droplet nuclei and that the large droplets with D≥ 500 μm and initial velocity u0≥ 5 m/s travel more than 2 m. Winter conditions of low temperature and high relative humidity can
cause more droplets to settle to the ground, which may be a possible driver of a second pandemic wave in the autumn and winter seasons. |
|
|
Wang, M, Chen, et al |
J Clin Lab Anal |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Evaluated the analytical performance of five commercial RT-PCR kits (Genekey, Daan, BioGerm, Liferiver, and Yaneng)
commonly used in China. The positive detection rate was 100% for Genekey, Daan, and BioGerm,and 90% for Liferiver and Yaneng in 20 clinical SARS-CoV-2 infection. The coincidence rate of five kits in 10 negative samples was 100%. The detection rate of target
genes for Daan, BioGerm, Liferiver, and Yaneng was 100% from Level 1 to Level 3. In Level 4, only Daan detection rate was 100%. In Level 5, five kits presented poor positive rate. The limit of detection declared by each manufacturer was verified. The repeatability
for target genes was less than 5% and so did the total imprecision. There is no cross-reactivity of five kits with six human coronaviruses and four respiratory pathogens for ORF1ab and N gene. Five RT-PCR kits assessed in this study showed acceptable analytical
performance characteristics. |
|
|
Wang, S, Green, et al |
Environ Sci Process Impacts |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
Wastewater entering sewer networks represents a unique source of pooled epidemiological information. In this study,
we coupled online solid-phase extraction with liquid chromatography-high resolution mass spectrometry to achieve high-throughput analysis of health and lifestyle-related substances in untreated municipal wastewater during the coronavirus disease 2019 (COVID-19)
pandemic. Twenty-six substances were identified and quantified in influent samples collected from six wastewater treatment plants during the COVID-19 pandemic in central New York. Over a 12 week sampling period, the mean summed consumption rate of six major
substance groups (i.e., antidepressants, antiepileptics, antihistamines, antihypertensives, synthetic opioids, and central nervous system stimulants) correlated with disparities in household income, marital status, and age of the contributing populations as
well as the detection frequency of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in wastewater and the COVID-19 test positivity in the studied sewersheds. Nontarget screening revealed the covariation of piperine, a nontarget substance, with
SARS-CoV-2 RNA in wastewater collected from one of the sewersheds. Overall, this proof-of-the-concept study demonstrated the utility of high-throughput wastewater analysis for assessing the population-level substance use patterns during a public health crisis
such as COVID-19. |
|
|
Wang, Y, Zhang, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
The objective of this study is to determine if there was any change in daily steps, an important component of daily
physical activity, and examine risk factors for frequent low daily steps during the COVID-19 epidemic. Daily steps of Changsha residents aged ≥40 years dropped significantly during the COVID-19 period, especially among older adults and females. Our findings
of an increase in the prevalence of frequent low daily steps raise concerns about unintended effects on physical activity. |
|
|
Wang, Yuke, Siesel, et al |
medRxiv |
Transmission Public health interventions*| Interventions de santé publique |
In this study, we examined the COVID-19 transmission in the state of Georgia, United States. Methods During February
1-July 13, 2020, we identified 4080 transmission pairs using contact information from reports of COVID-19 cases from the Georgia Department of Public Health. We examined how various transmission characteristics were affected by disease symptoms, demographics
(age, gender, and race), and time period (during shelter-in-place and after reopening). Over this period, the serial interval appeared to decrease from 5.97 days in February-April to 4.40 days in June-July. The shelter-in-place was not long enough to sufficiently
suppress COVID-19 transmission in densely populated urban areas connected by major transportation links. |
|
|
Wong, CK, Luk, et al |
Circ J |
Coronavirology| Coronavirologie |
SARS-CoV-2 infection is associated with myocardial injury, but there is a paucity of experimental platforms for the
condition. Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) infected by SARS-CoV-2 for 3 days ceased beating and exhibited cytopathogenic changes with reduced viability. Active viral replication was evidenced by an increase in supernatant
SARS-CoV-2 and the presence of SARS-CoV-2 nucleocaspid protein within hiPSC-CMs. Expressions of BNP, CXCL1, CXCL2, IL-6, IL-8 and TNF-α were upregulated, while ACE2 was downregulated. Our hiPSC-CM-based in-vitro SARS-CoV-2 myocarditis model recapitulated the
cytopathogenic effects and cytokine/chemokine response. It could be exploited as a drug screening platform. |
|
|
First case of COVID-19 infused with hESC derived immunity- and matrix-regulatory
cells |
Wu, J, Hu, et al |
Cell Prolif |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
we pilot‐tested GMP‐grade immunity‐ and matrix‐regulatory cells (IMRCs) transfusion as a compassionate treatment in
a severely ill COVID‐19 patient who was diagnosed with Acute lung injury (ALI). No severe adverse events were observed one month after IMRC infusion. |
|
Phase 1 trial for treatment of COVID-19 patients with pulmonary fibrosis
using hESC-IMRCs |
Wu, J, Zhou, et al |
Cell Prolif |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
we describe a Phase 1 clinical trial where we treated COVID‐19 patients with pulmonary fibrosis using human embryonic
stem cell–derived immunity‐ and matrix‐regulatory cells (hESC‐IMRCs) during the SARS‐CoV‐2 outbreak in Wuhan City. In this Phase 1 trial, we have demonstrated that hESC‐IMRCs are safe for intravenous infusion in the medium term, and our preliminary results
showed efficacy for pulmonary fibrosis in COVID‐19 patients. |
|
Analysis of college students' psychological anxiety and its causes under COVID-19 |
Wu, M, Zhao, et al |
|
Public Health response| Interventions de santé publique |
In this paper, SAS(Self-Rating Anxiety Scale) was used to evaluate and analyze students' anxiety in one of the Top
20 universities in China. A total of 3, 611 valid questionnaires from 34 provincial administrative regions and Taiwan in China were collected. The results show that the average scores of the forward scoring items were relatively high. For the anxious samples,
there were fewer arms and legs tingling, arms and legs trembling and syncope. The main causes of anxiety among college students included online learning and epidemic diseases. |
|
Anxiety and depression in frontline health care workers during the outbreak of Covid-19 |
Xing, LQ, Xu, et al |
Int J Soc Psychiatry |
Healthcare Response | Réponse des soins de santé |
We aim to assess the psychological impact of Covid-19 on frontline health care workers (HCWs), including anxiety, depression
and stress of threat of the disease. Among the 309 participants, there were 88 (28.5%) with anxiety and 172 (56.0%) with depression. Age ⩽ 30 years,
age > 30 to 45 years, working in confirmed case isolation wards, and worrying about disinfection measures being not sufficient were independently associated with anxiety. Age ⩽ 30 years,
age > 30 to 45 years, nurse and worrying about disinfection measure being not sufficient were independently associated with depression |
|
Xu, J, Wang, et al |
J Neurol |
Healthcare Response | Réponse des soins de santé |
Deep brain stimulation (DBS) is an effective treatment for patients with Parkinson's disease (PD). On time follow-up
and timely programing of symptoms are important measures to maintain the effectiveness of DBS. With the help of Internet technologies, we continued to provide motor and non-motor symptom assessment and remote programming services for postsurgical PD-DBS patients
during 2019-nCoV lockdown. Of the 36 patients engaged in the remote programming, 32 patients met the inclusion criteria. Four of the 32 patients set initiated stimulation parameters, and the other 28 patients had significant improvement in UPDRS-III. Nearly
all the 28 patients were satisfied with the effect of the remote programming. Most of the patients were willing to use remote programming again. |
|
|
Early Warning of COVID-19 Hotspots using Mobility of High Risk Users from Web Search Queries |
Yabe, Takahiro, Tsubouchi, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Web search queries have been shown to be good predictors of the disease spread. In this study, we utilize a unique
dataset of human mobility trajectories (GPS traces) and web search queries with common user identifiers (> 450K users), to predict COVID-19 hotspot locations beforehand. More specifically, web search query analysis is conducted to identify users with high
risk of COVID-19 contraction, and social contact analysis was further performed on the mobility patterns of these users to quantify the risk of an outbreak. We show that by integrating COVID-19 related web search query analytics with social contact networks,
we are able to predict COVID-19 hotspot locations 1-2 weeks beforehand, compared to just using social contact indexes or web search data analysis. This study proposes a novel method that can be used in early warning systems for disease outbreak hotspots, which
can assist government agencies to prepare effective strategies to prevent further disease spread. |
|
Yammine, H, Ballast, et al |
J Vasc Surg Cases Innov Tech |
Clinical data| Données cliniques |
In this report, we present the case of a COVID-19-positive patient whose symptomatic inflammatory abdominal aortic
aneurysm was successfully treated with endovascular aortic repair at our institution. We discuss the reasoning behind the type of therapy used and the various lessons learned. Based on our experience with this patient, we recommend an endovascular approach
for similar COVID-19 patients and suggest a prophylactic dose of enoxaparin (Lovenox; 40 mg daily) postoperatively for 14 days. |
|
|
Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration |
Yang, Q, Hughes, et al |
Elife |
Coronavirology| Coronavirologie |
We expressed different glycoforms of the Spike-protein and ACE2 in CRISPR-Cas9 glycoengineered cells, and developed
corresponding SARS-CoV-2 pseudovirus. Blocking N-glycan biosynthesis at the oligomannose stage using both genetic approaches and the small molecule kifunensine dramatically reduced viral entry into ACE2 expressing HEK293T cells. Blocking O-glycan elaboration
also partially blocked viral entry. Mechanistic studies suggest multiple roles for glycans during viral entry. Among them, inhibition of N-glycan biosynthesis enhanced Spike-protein proteolysis. This could reduce RBD presentation on virus, lowering binding
to host ACE2 and decreasing viral entry. |
|
Yörük, S, Güler, et al |
Perspect Psychiatr Care |
Healthcare Response | Réponse des soins de santé |
This study aims to determine the relationship between psychological resilience, burnout, stress, and sociodemographic
factors with depression in nurses and midwives during the COVID-19 pandemic in Turkey. The prevalence of depression in midwives and nurses in our sample was 31.8%. The risk of depression in midwives was 1.92 times higher than that of nurses. A high perceived
stress score increased the risk of depression by 1.16 times, and a high emotional exhaustion score increased the risk of depression by 1.11 times. A high psychological resilience score was found to be protective against depression |
|
|
Yu, W, Wu, et al |
Comb Chem High Throughput Screen |
Coronavirology| Coronavirologie |
Molecular dynamics (MD) simulation combined with MM/PBSA and CAS methods were performed to investigate the binding
mechanism of binding of CR3022 against SARS-CoV-RBD and HCoV-19-RBD in order to determine their holographic dynamic information. It was found that the CR3022-SARS-CoV-RBD complex was more stable during 100ns MD run than that of the CR3022-HCoV19-RBD system.
There were common conservative amino acids on the β2 sheet of RBD, including Tyr369, Phe377, Lys378, Tyr380, Gly381, Lys386, Leu390 and others. These conservative amino acids play significant roles in the binding process of CR3022 antibody against SARS-CoV-RBD
and HCoV-19-RBD. It was also found that the binding mode of CR3022 to its native target SARS-CoV-RBD is more comprehensive and uniform. Moreover, the β2 sheet residue Thr385 and non-β2 sheet residues Arg408 and Asp428 of the CR3022- SARS-CoV-RBD system were
found to be crucial for their binding affinities, thus forming a special conformational epitope. However, these key amino acids are not present in the CR3022-HCoV-19-RBD system. The binding mode of CR3022 and HCoV-19-RBD is similar to that of SARS-CoV-RBD,
but the deficiency of crucial hydrogen-bonds and salt-bridges. Therefore, the binding of CR3022 and HCoV19-RBD only draws on the partial mode of the binding of CR3022 and SARS-CoV-RBD, so there is a loss of affinity. |
|
|
Yu, Wenhua, Xu, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie |
We aimed to assess whether the association between cold temperature and all-cause mortality in the pandemic period
has changed or not compared to the non-COVID-19 period (2015-2019) in Italy. The findings suggest that the COVID-19 pandemic enhanced the risk of cold temperature on mortality in Italy, particularly among the elderly people. |
|
|
Global to local impacts on atmospheric CO2 caused by COVID-19 lockdown |
Zeng, Ning, Han, et al |
arXiv |
Public health interventions*| Interventions de santé publique |
We used a state-of-the-art atmospheric transport model to simulate CO2, driven by a new daily fossil fuel emissions
dataset and hourly biospheric fluxes from a carbon cycle model forced with observed climate variability. Our results show a 0.13 ppm decrease in atmospheric column CO2 anomaly averaged over 50S-50N for the period February-April 2020 relative to a 10-year climatology.Using
model sensitivity experiments, we further found that COVID, the biosphere and weather contributed 54%, 23%, and 23% respectively.The ability of our current carbon monitoring systems in detecting the small and short-lasting COVID signal on the background of
fossil fuel CO2 accumulated over the last two centuries is encouraging. |
|
Prediction and control of COVID-19 infection based
on a hybrid intelligent model |
Zhang, Gengpei, Liu, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this study, a hybrid intelligent model is proposed to simulate the spreading dynamics of COVID-19. First, considering
the control measures, such as government investment, media publicity, medical treatment and law enforcement. This study provide a reliable model to predict cases of infection and death, and reasonable suggestion to control COVID-19. |
|
Zhang, L, Fan, et al |
Aging (Albany NY) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study compared clinical characteristics between COVID-19 patients ≥ 70 and those < 70. Clinical data of consecutive
222 patients hospitalized in Wuhan were used. Higher proportions of dyspnoea, expectoration, chronic cardiovascular disease, diabetes, organ complications, severe-to-critical cases, a higher death rate, a longer hospital stay and decreased immune status were
observed in the over-70 group patients compared with their younger counterparts. The risk factors for death included dyspnoea, muscle ache, elevated myocardial enzymes, elevated C3 in over-70 patients and dyspnoea, pharyngalgia, chronic cardiac disease, increased
C-reactive protein, IgA, decreased platelets in under-70 patients. |
|
|
COUGH: A Challenge Dataset and Models for COVID-19 FAQ Retrieval |
Zhang, Xinliang Frederick, Sun, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We present a large challenging dataset, COUGH, for COVID-19 FAQ retrieval. Specifically, similar to a standard FAQ
dataset, COUGH consists of three parts: FAQ Bank, User Query Bank and Annotated Relevance Set. FAQ Bank contains ~16K FAQ items scraped from 55 credible websites (e.g., CDC and WHO). For evaluation, we introduce User Query Bank and Annotated Relevance Set,
where the former contains 1201 human-paraphrased queries while the latter contains ~32 human-annotated FAQ items for each query. We analyze COUGH by testing different FAQ retrieval models built on top of BM25 and BERT, among which the best model achieves 0.29
under P@5, indicating that the dataset presents a great challenge for future research. Our dataset is freely available at this https URL. |
|
Media trust and infection mitigating behaviours during the COVID-19 pandemic in
the USA |
Zhao, E, Wu, et al |
BMJ Global Health |
Public Health response| Interventions de santé publique |
This study determined if COVID-related behaviors (preventive and risky behaviors) differed according to trust in left-leaning
or right-leaning media and how differences changed over the first several months of the pandemic. Results showed that compared with those who trust CNN more than Fox news, people who trust Fox News more than CNN engaged in fewer preventive behaviours and more
risky behaviours related to COVID-19. Out of five preventive and five risky behaviours examined, people who trust Fox News more than CNN practised an average of 3.41 preventive behaviours and 1.25 risky behaviours, while those who trust CNN more than Fox News
engaged in an average of 3.85 preventive and 0.94 risky behaviours, from late March to June. The difference between these two groups widened in the month of May (p≤0.01), even after controlling for access to professional information and overall diversity of
information sources. |
|
Zhao, F, Liu, et al |
Science of the Total Environment |
Public health interventions*| Interventions de santé publique |
This paper presents ozone profiles and tropospheric ozone columns from ultraviolet radiances detected by TROPOospheric
Monitoring Instrument (TROPOMI) onboard Sentinel 5 Precursor (S–5P) satellite based on the principle of optimal estimation method. Although NO2 TVCD decreased by 63%, the retrieved TOC over east China increase by 10% from the 20-day averaged before the lockdown
on January 23, 2020 to 20-day averaged after it. Because the production of ozone in winter is controlled by volatile organic compounds (VOCs) indicated by monitored HCHO, which did not present evident change during the lockdown, the production of ozone did
not decrease significantly. Besides, the decrease of NOx emission weakened the titration of ozone, causing an increase of ozone. |
|
|
Zhou, N, Zhang, et al |
Disaster Med Public Health Prep |
Epidemiology| Épidémiologie |
Based on the public data from the health departments of Tianjin and Shenzhen, we conducted a comparative analysis of
the corona virus disease 2019 (COVID-19) epidemic situation between these two cities. The aim of this study was to evaluate the role of public data in epidemic prevention and control of COVID-19, providing a scientific advice for the subsequent mitigation
and containment of COVID-19 prevalence. |
|
|
Ziaei, A, Davoodian, et al |
Trials |
RCT |
OBJECTIVES: We will evaluate the efficacy and safety of Melatonin, compared to the standard therapeutic regimen on
clinical symptoms and serum inflammatory parameters in patients with confirmed COVID-19, who are moderately ill. TRIAL DESIGN: This is a single-center, randomized, double-blind, placebo-controlled clinical trial with a parallel-group design conducted at Shahid
Mohammadi Hospital, Bandar Abbas, Iran. PARTICIPANTS: All patients admitted to Severe Acute Respiratory Syndrome Departments of Shahid Mohammadi Hospital, Bandar Abbas, Iran will be screened for the following criteria. INCLUSION CRITERIA: 1. Age ≥20 years
2. Confirmed SARS-CoV-2 diagnosis (positive polymerase chain reaction). 3. Moderate COVID-19 pneumonia (via computed tomography and or X-ray imaging), requiring hospitalization. 4. Hospitalized ≤48 hours. 5. Signing informed consent and willingness of the
participant to accept randomization to any assigned treatment arm. EXCLUSION CRITERIA: 1. Underlying diseases, including chronic hypertension, diabetes mellitus, seizure, depression, chronic hepatitis, cirrhosis, and cholestatic liver diseases. 2. Severe and
critical COVID-19 pneumonia. 3. Use of warfarin, corticosteroids, hormonal drugs, alcohol, other antiviral and investigational medicines, and illegal drugs (during the last 30 days). 4. History of known allergy to Melatonin. 5. Pregnancy and breastfeeding.
INTERVENTION AND COMPARATOR: Intervention group: The standard treatment regimen for COVID-19, according to the Iranian Ministry of Health and Medical Education's protocol, along with Melatonin capsules at a dose of 50 mg daily for a period of seven days. CONTROL
GROUP: The standard therapeutic regimen for COVID-19 along with Melatonin-like placebo capsules at a dose of one capsule daily for a period of seven days. Both Melatonin and placebo capsules were prepared at the Faculty of Pharmacy and Pharmaceutical Sciences,
Hormozgan University of Medical Sciences, Bandar Abbas, Iran. MAIN OUTCOMES: The primary outcomes are the recovery rate of clinical symptoms and oxygen saturation as well as improvement of serum inflammatory parameters, including C-reactive protein, tumor
necrosis factor-alpha (TNF-ɑ), interleukin-1β (IL-1β), and IL-6 within seven days of randomization. The secondary outcomes are the time to improve clinical and paraclinical features along with the incidence of serious adverse drug reactions within seven days
of randomization. RANDOMIZATION: Included patients will be allocated to one of the study arms using block randomization in a 1:1 ratio (each block consists of 10 patients). This randomization method ensures a balanced allocation between the arms during the
study. A web-based system will generate random numbers for the allocation sequence and concealment of participants. Each number relates to one of the study arms. BLINDING (MASKING): All study participants, clinicians, nurses, research coordinators, and those
analyzing the data are blinded to the group assignment. NUMBERS TO BE RANDOMIZED (SAMPLE SIZE): A total of 60 patients randomized into two groups (30 in each group). TRIAL STATUS: The trial protocol is Version 1.0, August 14, 2020. Recruitment began August
22, 2020, and is anticipated to be completed by November 30, 2020. TRIAL REGISTRATION: The trial protocol has been registered in the Iranian Registry of Clinical Trials (IRCT). The registration number is " IRCT20200506047323N5 ". The registration date was
14 August 2020. FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting the dissemination of this material, the familiar formatting has been eliminated; this
Letter serves as a summary of the key elements of the full protocol. |
|
|
Agba, AMO, Ocheni, et al |
Journal of Educational and Social Research |
Review Literature| Revue de littérature |
|
|
|
Novel Coronavirus SARS-CoV-2 (COVID-19) and Pregnancy: A hypothetical view |
Ahmed, Rg |
Endocr Metab Immune Disord Drug Targets |
Review Literature| Revue de littérature |
|
|
Albulescu, R, Dima, et al |
Exp Ther Med |
Review Literature| Revue de littérature |
|
|
|
Computational Intelligence in Vaccine Design Against COVID-19 |
Bharadwaj, KK, Srivastava, et al |
Studies in Computational Intelligence |
Review Literature| Revue de littérature |
|
|
Are patients with asthma and COPD preferred targets of COVID-19? |
Bouazza, B, Hadj-Said, et al |
Tuberc Respir Dis (Seoul) |
Review Literature| Revue de littérature |
|
|
Cognitive Assessment via Telephone: A Scoping Review of Instruments |
Carlew, AR, Fatima, et al |
Arch Clin Neuropsychol |
Review Literature| Revue de littérature |
ScR: searching of the PubMed and EBSCO databases. Overall, literature suggests that TBCA is a viable modality for
identifying cognitive impairment in various populations. However, the mode of assessment selected clinically should reflect an understanding of the purpose, evidence, and limitations for various tests and populations. Most identified measures were developed
for research application to support gross cognitive characterization and to help determine when more comprehensive testing was needed. While TBCA is not meant to replace gold-standard, face-to-face evaluation, if appropriately utilized, it can expand scope
of practice, particularly when barriers to standard neuropsychological assessment occur. |
|
Chen, HX, Chen, et al |
Sheng Li Xue Bao |
Review Literature| Revue de littérature |
|
|
|
Low serum vitamin D level and COVID-19 infection
and outcomes, a multivariate meta-analysis |
chen, jie, xie, et al |
medRxiv |
Review Literature| Revue de littérature |
MA: PubMed, Embase, and medRxiv databases from December 2019 to October 1, 2020 were searched.Low serum vitamin D is
associated with an increased risk of COVID-19 infection and hospitalization. In-hospital death showed a tendency to be increased in COVID-19 patients with low vitamin D levels. The ongoing clinical trials for evaluation of vitamin D supplementation will be
key to the validation of this adjunctive treatment for COVID-19 patients. |
|
Comber, L, E, et al |
Rev Med Virol |
Review Literature| Revue de littérature |
SR: Systematic literature searches were conducted in PubMed, Embase, Europe PMC and National Health Service UK evidence
up to 27 July 2020. Epidemiological studies suggest possible transmission, with contextual factors noted. Viral particles have been detected in air sampling studies with some evidence of clinical infectivity, and virological studies indicate these particles
may represent live virus, adding further plausibility. |
|
|
An overview of potential therapeutic agents to treat COVID-19 |
Dong, X, Tian, et al |
Biosci Trends |
Review Literature| Revue de littérature |
|
|
Douthit, BJ |
Int J Health Plann Manage |
Review Literature| Revue de littérature |
|
|
|
Fang, FC, Benson, et al |
Clin Infect Dis |
Review Literature| Revue de littérature |
|
|
|
Gmehlin, C, Munoz-Price, et al |
Infect Control Hosp Epidemiol |
Review Literature| Revue de littérature |
|
|
|
The First-Three-Month Review of Research on Covid-19: A Scientometrics
Analysis |
Harsanto, B |
|
Review Literature| Revue de littérature |
|
|
Prognosis and Treatment of Liver Transplant Recipients in the COVID-19 Era: A Literature
Review |
Imam, A, Abukhalaf, et al |
Ann Transplant |
Review Literature| Revue de littérature |
|
|
Khan, FN, Khanam, et al |
Studies in Computational Intelligence |
Review Literature| Revue de littérature |
|
|
|
Kumar, R, Kumar Srivastava, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
|
|
|
Li, SD, Liu, et al |
Victims and Offenders |
Review Literature| Revue de littérature |
|
|
|
M, R, S, et al |
Immunopharmacol Immunotoxicol |
Review Literature| Revue de littérature |
SR: This review aims to show the host-viral interaction along with immune response, antiviral mechanism and effectiveness
of oral low dose cytokines against virus as a therapeutic approach. |
|
|
Responding to COVID-19 in an African university: the case the National University
of Lesotho library |
Mbambo-Thata, B |
Digital Library Perspectives |
Review Literature| Revue de littérature |
|
|
Mohandas, S, Vairappan, et al |
J Dig Dis |
Review Literature| Revue de littérature |
|
|
|
Mohapatra, S, Menon, et al |
Science of the Total Environment |
Review Literature| Revue de littérature |
|
|
|
Evidence and the main adverse effects regarding drug therapies in the war
against COVID-19 |
Mora-Ramírez, M, Melgoza-Hernández, et al |
Curr Med Chem |
Review Literature| Revue de littérature |
|
|
EXPRESS: Stroke in COVID-19: a systematic review and meta-analysis |
Nannoni, S, de Groot, et al |
Int J Stroke |
Review Literature| Revue de littérature |
SR-MA: Three medical databases were systematically reviewed for published articles on acute CVD in COVID-19 (December
2019-September 2020). Acute CVD is not uncommon in COVID-19, especially in those whom are severely infected and have pre-existing vascular risk factors.
|
|
Convalescent plasma: A potential therapeutic option for COVID-19 patients |
Ng, SL, Soon, et al |
Asian Pacific Journal of Tropical Medicine |
Review Literature| Revue de littérature |
|
|
Ortega, JT, Zambrano, et al |
Intervirology |
Review Literature| Revue de littérature |
|
|
|
Patel, M, Chaubey, et al |
Science of the Total Environment |
Review Literature| Revue de littérature |
|
|
|
Pinedo-Torres, I, Flores-Fernández, et al |
Clinical Medicine Insights: Endocrinology and Diabetes |
Review Literature| Revue de littérature |
SR-MA: review of literature in Pubmed/Medline, Scopus, Web of Science, Cochrane, and Scielo until April of 2020. The
prevalence of DM in patients with acute respiratory syndrome due to coronaviruses is high, predominantly with MERS-Cov infection. The unfavorable health outcomes are frequent in this subset of patients. Well-powered and population-based studies are needed,
including detailed DM clinical profile (such as glycemic control, DM complications, and treatment regimens), comorbidities, and SARS-Cov-2 evolution to reevaluate the worldwide prevalence of this comorbidity and to typify clinical phenotypes with differential
risk within the subpopulation of DM patients. |
|
|
Piscoya, Alejandro, Ng-Sueng, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
SR-MA: We searched five engines until September 8, 2020. n comparison to SOC, CP did not reduce all-cause mortality
in RCTs of moderate or severe COVID-19, but did reduce it in cohorts. CP did not increase clinical improvement or reduce invasive ventilation. Adverse events were scarce. |
|
|
Prasad, Bhupendra |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
|
|
|
Covid-19: Considerations in the management of airway in pediatric patients |
Sánchez-Hernández, E, Rodríguez-Arias, et al |
Acta Pediatrica de Mexico |
Review Literature| Revue de littérature |
|
|
Sanghvi, AR |
Int J Dermatol |
Review Literature| Revue de littérature |
|
|
|
Shukla, Govind, Kanade, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
|
|
|
Role of Oxidative Stress on SARS-CoV (SARS) and SARS-CoV-2 (COVID-19) Infection:
A Review |
Suhail, S, Zajac, et al |
Protein J |
Review Literature| Revue de littérature |
|
|
Sun, TT, Zhu, et al |
Curr Med Chem |
Review Literature| Revue de littérature |
|
|
|
Wijaya, I, Andhika, et al |
Clinical and Applied Thrombosis/Hemostasis |
Review Literature| Revue de littérature |
SR: search was carried out using the electronic databases of PubMed, EuropePMC, and the Cochrane Central Database.
Although it is too soon to draw any conclusions, this systematic review draws attention to current evidence regarding the association between therapeutic-dose anticoagulation and its effect on mortality in patients with COVID-19.
|
|
|
Wilcha, RJ |
JMIR Med Educ |
Review Literature| Revue de littérature |
|
|
|
Abbara, A, Ekzayez, et al |
Lancet Glob Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7547825; Role of micronutrients in the management of coronavirus disease 2019 |
AbdAllah, M, Ez Elarab, et al |
New Microbes New Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19: Topical Agents and Therapeutic Prevention of Nasal Viral Acquisition |
Abdelhadi, S, Ruszczak, et al |
Dermatol Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cutaneous manifestation of COVID-19 reporting from Middle-Eastern countries: A point of
view! |
Abdelmaksoud, A, Shakshouk, et al |
Int J Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19: a user's guide, status of the art, and an original proposal to terminate
viral recurrence |
Actis, GC, Ribaldone, et al |
Minerva Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
What the Regions Can Do to Overcome Stagnation and Rekindle Significant Socioeconomic
Growth |
Aganbegyan, AG |
Regional Research of Russia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Agarwal, A, Vishnu, et al |
Stroke |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Digital Image Analysis Is a Silver Bullet to COVID-19 Pandemic |
Aggarwal, S, Singh, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
How the Coronavirus Lockdown Impacts the Impoverished in India |
Agoramoorthy, G, Hsu, et al |
J Racial Ethn Health Disparities |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Aguilar, MS |
Educacion Matematica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ahluwalia, InduB, Myers, et al |
The Lancet Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mobile Technology Solution for COVID-19: Surveillance and Prevention |
Ahmad, S, Chitkara, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Computational Intelligence Methods for the Diagnosis of COVID-19 |
Akermi, S, Sinha, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Alaszewski, A |
British Journal of Midwifery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Management of hematological malignancies during the COVID-19 pandemic |
Aleem, A, Altowairqi, et al |
Journal of Applied Hematology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7267800; Improved Safety of Endoscopic Vessel Harvesting During the COVID-19
Pandemic |
Ali Hassan, SM, Palacios, et al |
Ann Thorac Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
"It's Pure Panic": The Portrayal of Residential Care in American Newspapers During
COVID-19 |
Allen, LD, Ayalon, et al |
Gerontologist |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Alsaif, HI, Aldhayan, et al |
International Journal of General Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Editorial:
COVID-19 and ornithology: will 2020 be a sad gap in our data? |
Ambrosini, R |
Avocetta |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Amit, AriannaMaeverL, Pepito, et al |
medRxiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 and preventative medicine for HIV infected children |
Anderson, L, Caniza, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Why Pandemics, Such as COVID-19, Require a
Metropolitan Response |
Angel, Shlomo, Blei, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Annweiler, C, Lagarce, et al |
Clin Teach |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32997045; Virtual meetings and social isolation in covid-19 times: Transposable
barriers |
Antonello, VS, Panzenhagen, et al |
Trends in Psychiatry and Psychotherapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32703771; Confronting and mitigating the risk of COVID-19 associated pulmonary
aspergillosis |
Armstrong-James, D, Youngs, et al |
European Respiratory Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Atallah, J, Shah, et al |
Clinical imaging |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7543775; Challenges and accurate estimates of mortality and case-fatality rates
due to COVID-19 |
Azizi, H, Esmaeili, et al |
New Microbes New Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7568490; The challenge of producing an EQA for the COVID-19 pandemic |
Badrick, T, Wienholt, et al |
Pract Lab Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Addressing the intersection between COVID-19 and young people vaping: timely resources
needed |
Bandara, NA, Herath, et al |
Cmaj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Can Cytokine Blocking Prevent Depression in COVID-19 Survivors? |
Benedetti, F, Mazza, et al |
J Neuroimmune Pharmacol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Benson, MD, Buxbaum, et al |
Amyloid |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Atypical lymphocytes in bronchoalveolar lavage fluid from patients with COVID-19
ARDS |
Berg, RMG, Ronit, et al |
Pathology Research and Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The COVID-19, migration and livelihood in India: Challenges and policy issues |
Bhagat, RB, Reshmi, et al |
Migration Letters |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hospital Volumes of 5 Medical Emergencies in the COVID-19 Pandemic in 2 US
Medical Centers |
Bhambhvani, HP, Rodrigues, et al |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Revisited COVID-19 Mortality and Recovery Rates: Are we Missing Recovery Time Period? |
Bhapkar, HR, Mahalle, et al |
J Med Syst |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 and the Lebanese Crisis: Will the Phoenix Manage to Rise Once Again? |
Bizri, AR, Alam, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
This Time is Different? - On the Use of Emergency Measures During the Corona Pandemic |
Bjørnskov, Christian, Voigt, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hospitalizations for Chronic Disease and Acute Conditions in the Time of COVID-19 |
Blecker, S, Jones, et al |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Borsellino, V, Kaliji, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 Highlights the Need for More Effective Wildlife Trade Legislation |
Borzée, A, McNeely, et al |
Trends in Ecology and Evolution |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bromley, J |
British Journal of Health Care Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Co-spread of Misinformation and Fact-Checking Content During the Covid-19 Pandemic |
Burel, G, Farrell, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Origin of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and COVID-19 |
Byard, RW, Hunsaker, et al |
Forensic Sci Med Pathol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Health services in northern Australia depend on student placements post COVID-19 |
Campbell, N, Stothers, et al |
Aust N Z J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Additional Concerns Regarding Children With Coronavirus Disease 2019-Reply |
Castagnoli, R, Licari, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cervera-Ubierna, A |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Healthcare Personnel Absenteeism, Presenteeism, and Staffing Challenges During Epidemics |
Challener, DW, Breeher, et al |
Infect Control Hosp Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Chan, Y, Angel, et al |
J Otolaryngol Head Neck Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Caring for Blind and Vision Impaired Dermatological Patients During the COVID-19 Pandemic |
Chang, MJ, Lipner, et al |
Dermatol Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Charlton, D, Castillo, et al |
Applied Economic Perspectives and Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chen, LL |
Nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Additional Concerns Regarding Children With Coronavirus Disease 2019 |
Chen, YC, Chiu, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cheung, ATM, Parent, et al |
J Med Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chou, R, Dana, et al |
Ann Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Impact of COVID-19 on Inpatient Psychiatry Resident Supervision |
Coe, WH, Millard, et al |
Acad Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Social distancing as a critical test of the micro-sociology of solidarity |
Collins, R |
American Journal of Cultural Sociology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cardiopulmonary resuscitation in the pediatric patient with suspicion or
carrier of COVID-19 |
Correa-Flores, M, Menéndez-Suso, et al |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Craig, CA |
Annals of Tourism Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cucchiari, D, Guillen, et al |
Clin Transplant |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Darvall, JaiN, Bellomo, et al |
The Lancet Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
David, J, Sibikova, et al |
Klin Padiatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
De Grazia, F, Marconi, et al |
Endoscopy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Radiographic evaluation of the pediatric patient with COVID-19 |
de Uña-Flores, A |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
[Patient satisfaction during the COVID-19 pandemic in an emergency department] |
Deák, A, Fusz, et al |
Orv Hetil |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Deferral of Care for Serious Non-COVID-19 Conditions: A Hidden Harm of COVID-19 |
DeJong, C, Katz, et al |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Delap, N |
British Journal of Midwifery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Díaz-Jiménez, IV |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Diegoli, H, Magalhães, et al |
Stroke |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lock Unlock: The Impact of COVID-19 on Health Security in Pakistani and Indian
Prisons |
Dmello, JR, Ranjan, et al |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Donatelli, F, Miceli, et al |
Interact Cardiovasc Thorac Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Dorofeev, VP, Lebedev, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19: How
to switch from twice-daily to once-daily basal insulin |
Down, S |
Journal of Diabetes Nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
D'Souza, K, Huynh, et al |
J Trauma Acute Care Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Duck, W, Rawls, et al |
Etnografia e Ricerca Qualitativa |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Impact of Covid-19 on Prisons and Penal Policy in Germany |
Dünkel, F |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Precautions in neonatal care in the delivery room with a mother suspected
or positive for COVID 19 |
Durán-Colosio, MP, Rodríguez-Weber, et al |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Durmaz, B, Abdulmajed, et al |
Medeniyet Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7482609; Indirect effects of COVID-19 on OHCA in a low prevalence region |
Elmer, J, Okubo, et al |
Resuscitation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Eren, ME, Solovyev, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 and the risk to black, Asian and minority ethnic women during pregnancy |
Esegbona-Adeigbe, S |
British Journal of Midwifery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Espinosa-Rosales, F |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rapid Computer Diagnosis for the Deadly Zoonotic COVID-19 Infection |
Etaware, PM |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Advances in Intelligent Based Internet of Medical Things (IoMT) for COVID-19:
Olfactory Disorders |
Evelyn Brindha, V, Anitha Mary, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Farrer, J |
Etnografia e Ricerca Qualitativa |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ethnography in the time of Covid-19: Vectors and the vulnerable |
Fine, GA, Abramson, et al |
Etnografia e Ricerca Qualitativa |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Smart city visions: pathways to participatory planning in two American cities |
Fletcher, AL |
Foresight |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ford, P |
Lancet Glob Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Response to 'Impact of immunosuppression on mortality in critically ill COVID-19 patients' |
Fox, TA, Troy-Barnes, et al |
Br J Haematol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Eosinophilic esophagitis: is the Th2 inflammation protective against the severe
form of COVID-19? |
Franceschini, L, Macchiarelli, et al |
Eur J Gastroenterol Hepatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Exploring Negative Emotions to Preserve Social Distance in a Pandemic Emergency |
Franzoni, V, Biondi, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Fuller, S, Vaporciyan, et al |
Ann Thorac Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Fusco, FM, Sangiovanni, et al |
Aids |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The time is now for public health to lead the way on addressing financial strain
in Canada |
Glenn, NM, Nykiforuk, et al |
Can J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Goggin, M, Vote, et al |
Clin Exp Ophthalmol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
González-Torres, T, Rodríguéz-Sánchez, et al |
Int J Hosp Manag |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Psychological impact of isolation due to COVID-19 among young and fit dormitory
residents |
Gosavi, TD, Koh, et al |
Psychol Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Berlin principles on one health – Bridging global health and conservation |
Gruetzmacher, K, Karesh, et al |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Guharoy, R, Krenzelok, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Oscillometry-A reasonable option to monitor lung functions in the era of COVID-19 pandemic |
Gupta, N, Sachdev, et al |
Pediatr Pulmonol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gurumurthy, CB, Quadros, et al |
Nat Protoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hage, R, Schuurmans, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hajdu, SD, Marto, et al |
Stroke |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Halpern, LW |
Am J Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
In response to: Laparoscopy may improve postoperative outcomes of COVID-19 patients |
Hamid, HKS |
J Trauma Acute Care Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Coronavirus Disease 2019 Autopsies and Personal Protective Equipment |
Han, B, Bhalla, et al |
Arch Pathol Lab Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hanaei, S, Takian, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Real versus fictitious the pandemic closing in on
the world of finance |
Harilal, KN |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Dementia is a predictor for mortality outcome from coronavirus disease 2019 (COVID-19)
infection |
Hariyanto, TI, Putri, et al |
Eur Arch Psychiatry Clin Neurosci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Remember the law: Managing patients who decline two-week rule appointments because
of COVID-19 |
Hayes, T |
British Journal of Health Care Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Additional Concerns Regarding Children With Coronavirus Disease 2019 |
He, D, Zhang, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7305762; Skin manifestations of COVID-19 resembling acute limb ischemia |
Heald, M, Fish, et al |
J Vasc Surg Cases Innov Tech |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Editorial: Foreign seasonal migrants in agriculture and COVID-19 |
Heikkilä, E |
Migration Letters |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hernández-Orozco, HG, Arias-De la Garza, et al |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hidalgo, A, Khan, et al |
Etnografia e Ricerca Qualitativa |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Digital Phenotyping to Enhance Substance Use Treatment During the COVID-19 Pandemic |
Hsu, M, Ahern, et al |
JMIR Ment Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Huda, T, Alexander, et al |
J Trauma Acute Care Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hyde, Z |
Med J Aust |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ierardi, AM, Carnevale, et al |
Journal of Endovascular Resuscitation and Trauma Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Does the COVID-19 pandemic provide an opportunity to eliminate the tobacco industry? |
Ioannidis, JohnPA, Jha, et al |
The Lancet Global Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Scientific petitions and open letters in the era of covid-19 |
Ioannidis, JP |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Computational Intelligence Methods in Medical Image-Based Diagnosis of COVID-19
Infections |
Isa, A |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Response by Ishida et al Regarding Article, "SARS-CoV-2 and Stroke in a New York
Healthcare System" |
Ishida, K, Torres, et al |
Stroke |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Iwata, K, Yoshimura, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Social distancing and promoting psychological well being during COVID-19 pandemic |
Jakhar, J, Kharya, et al |
Int J Soc Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pandemic-induced
constraints on rapid transformation to digital education |
Jesionkowska, J, Wild, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
The New “Essential”; Rethinking Social Goods in the Wake of Covid-19 |
Johnson, OlatundeC |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Animal-Assisted Support: Actionable Intervention for Burnout |
Jones-Schenk, J |
J Contin Educ Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Jung, J |
J Korean Med Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 and myeloproliferative neoplasms: some considerations |
Kamaz, B, Mullally, et al |
Leukemia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Karobari, MI, Marya, et al |
Asia Pac J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A Geographical Review: Novel Coronavirus (COVID-19) Pandemic |
Karthick, R, M |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
N95 Respirators for Dermatologic Surgery and Laser Procedures During COVID-19
and Beyond |
Kashlan, R, Lyons, et al |
Dermatol Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kasi, SG, Dhir, et al |
Indian Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kaur, S, Hasija, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
While U.S. nurses fight covid-19 in hospitals they also
fight burnout |
Kealy, A |
Journal of health care finance |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kessel, B, Sheffer, et al |
Journal of Endovascular Resuscitation and Trauma Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kim, JH, Levine, et al |
JAMA Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kim, JS |
Eighteenth-Century Fiction |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kishi, T, Mizuno, et al |
Circ J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Live under the same roof and pass down tacit
knowledge for NTT WEST to become a social ICT pioneer |
Kishimoto, T |
NTT Technical Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Klitzman, RL |
Am J Bioeth |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kwan, J, Lobotesis, et al |
Stroke |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Failures of energy policy in Ukraine in the context of energy security priorities |
Kytaiev, A, Chala, et al |
Polityka Energetyczna |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A flare up of idiopathic hypereosinophilic syndrome due to COVID-19 |
Laleh Far, V, Najafizadeh, et al |
Eur Heart J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lamplot, JD, Pinnamaneni, et al |
Orthopaedic Journal of Sports Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lane-Fall, M, Atkins, et al |
Anesthesiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Laurent, MichaëlR |
The Lancet Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Laxe, S, Ferri, et al |
Brain Inj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Innovation Strategies of Mature Resilient Businesses during the Covid-19
crisis |
Lecossier, A, Pallot, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lee, D, Heo, et al |
Am J Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lee, ES, Lee, et al |
JMIR Res Protoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Harvest of Tropical Wildlife
for Bushmeat and Traditional Medicine |
Lee, Tien Ming, Sigouin, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Leonini, L |
Polis (Italy) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
León-Lara, X, Otero-Mendoza, et al |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Preventing the Spread of SARS-CoV-2 With Masks and Other "Low-tech" Interventions |
Lerner, AM, Folkers, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Proportion of Adult Americans at Risk of Severe COVID-19 Illness |
Li, HL, Cheung, et al |
J Gen Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Li, J, Li, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Li, P, Huang, et al |
Pharmaceutical Care and Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A study on legal policy of public health emergency and COVID-19 |
Lin, CCC |
Taiwan Journal of Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Liu, H, Wang, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
López-Mejía, L, Núñez-Barrera, et al |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Reflections on collective insecurity and virtual resistance in the times of COVID-19
in Malaysia |
Lumayag, LA, del Rosario, et al |
Migration Letters |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Luo, Y |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lv, XH, Yang, et al |
Am J Gastroenterol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Management of the suspicious and infected neonate in the NICU |
Macías-Avilés, HA |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Applying Best Practices from Health Communication to Support a University's
Response to COVID-19 |
Mackert, M, Table, et al |
Health Commun |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mackey, K, Kansagara, et al |
Ann Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19: Why are age and obesity risk factors for serious disease? |
Mahase, E |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Medicine and Grief During the COVID-19 Era: The Art of Losing |
Maitra, A |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
ORF3a mutation associated higher mortality rate in SARS-CoV-2 infection |
Majumdar, P, Niyogi, et al |
Epidemiol Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Frequency of COVID-19 Symptoms in Healthcare Workers in a Large Health System |
Malenfant, JH, Newhouse, et al |
Infect Control Hosp Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Decreasing access to cancer diagnosis and treatment during the COVID-19 pandemic
in Poland |
Maluchnik, M, Podwójcic, et al |
Acta Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Manderson, Desmond |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pandemics and PSAs: Rapidly Changing Information in a New Media Landscape |
Manganello, J, Bleakley, et al |
Health Commun |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32844977; Mental health consequences of COVID-19: The next global pandemic |
Mari, JJ, Oquendo, et al |
Trends in Psychiatry and Psychotherapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cultural leisure in the time of COVID-19: impressions from the Netherlands |
Marques, L, Giolo, et al |
World Leisure Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Marzano, M |
Etnografia e Ricerca Qualitativa |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Frailty and mortality in patients with COVID-19 – Authors' reply |
McCarthy, Kathryn, Hewitt, et al |
The Lancet Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mental health and COVID-19: are we really all in this together? |
McGorry, P |
Med J Aust |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Extra corporeal membrane oxygenation (Ecmo) for patients with covid-19 |
McGreevy, DT, Seilitz, et al |
Journal of Endovascular Resuscitation and Trauma Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Michard, F, Shelley, et al |
Journal of clinical monitoring and computing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mocan, B, Fulea, et al |
Mechanisms and Machine Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Role of Internet of Things (IoT) in the Containment and Spread of the Novel
COVID-19 Pandemic |
Mohammed, IB, Isa, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Montopoli, M, Zumerle, et al |
Annals of Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Morelli, N, Immovilli, et al |
Stroke |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mudd, PA, Remy, et al |
J Clin Invest |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mughal, W, Mohammed, et al |
Rev Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Muñoz-Fernández, SI, Molina-Valdespino, et al |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nandi, S, Sarkis, et al |
Sustain Prod Consum |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Agile application of digital health interventions during the covid-19 refugee response |
Narla, NP, Surmeli, et al |
Annals of Global Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
May the new locally-acquired cases of COVID-19 have been linked to illegal entry into
Vietnam? |
Nguyen, THD |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nicotra, I, Petri, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Niemiec, E |
EMBO Rep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nyashanu, M, Pfende, et al |
Health Soc Care Community |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19: Adjustments for in the scientific research work in Mexico |
Ortega-Rubio, A, Murillo-Amador, et al |
Terra Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7455791; TikTok and Its Role in COVID-19 Information Propagation |
Ostrovsky, AM, Chen, et al |
J Adolesc Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pan, Daniel, Sze, et al |
The Lancet Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Quality of life and education in time of pandemic: A reflection
from the human movement sciences |
Penabad-Camacho, M, Márquez-Barquero, et al |
Revista Electronica Educare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pery, M, Lemoine, et al |
Resuscitation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Petrie, JR, Boyle, et al |
Diabet Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Fifteen-minute consultation: Does this child have COVID-19 (and does it matter)? |
Ponmani, C, Roland, et al |
Arch Dis Child Educ Pract Ed |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Premachandran, KP, Senthur Nambi, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
From phase transitions to Modern Monetary Theory: A framework for analyzing the pandemic
of 2020 |
Putnam, BH |
Review of Financial Economics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Qaseem, A, Etxeandia-Ikobaltzeta, et al |
Ann Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Using Computational Intelligence for Tracking COVID-19 Outbreak in Online Social
Networks |
Qazi, S, Ahmad, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rajagopal, N |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rajendram, R, Mahmood, et al |
Stroke |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ramiro-Mendoza, M |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Raza, K, Maryam, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Reynés-Manzur, JN, Vázquez-Rivera, et al |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rhee, C, Kanjilal, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rhee, P |
J Trauma Acute Care Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Richard, SA, Kampo, et al |
Journal of Immunology Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ricketts, H |
International Journal of Sociology and Social Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19: Tackling health inequalities is more urgent than ever, says new alliance |
Rimmer, A |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The reality of virtual care: Implications for cancer care beyond the pandemic |
Rodin, D, Lovas, et al |
Healthcare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 in LMICs: The Need to Place Stigma Front and Centre to Its Response |
Roelen, K, Ackley, et al |
European Journal of Development Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rohatgi, S, Karishma, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Roush, K |
Am J Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sacchetto, D, Raviolo, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin? |
Saeedi-Boroujeni, A, Mahmoudian-Sani, et al |
Basic Clin Pharmacol Toxicol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19: Hard Road to Find Integrated Computational Drug and Repurposing Pipeline |
Sahu, A, Qazi, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The secondary effects of a pandemic: «social distancing» and digital activism |
Saitta, P |
Etnografia e Ricerca Qualitativa |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Letter by Sajeev et al Regarding Article, "SARS-CoV-2 and Stroke in a New York
Healthcare System" |
Sajeev, JK, Burrell, et al |
Stroke |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Additional Concerns Regarding Children With Coronavirus Disease 2019 |
Salvatore, S, Marinoni, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Protipush Protein Powder: Effective Supplementation for Strengthen Your Immune System |
Sampoorna, M, M |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sansavini, A, Trombini, et al |
Psicologia Clinica dello Sviluppo |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Breaking isolation: Reflections on oral history and distance interviews |
Santhiago, R, de Magalhães, et al |
Anos 90 |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Hiker's Guide to the RIME Supplement: Choosing Directions in Research |
Sewell, JL, Leep Hunderfund, et al |
Acad Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Shallal, A, Kenney, et al |
Infect Control Hosp Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sharma, D, Nawab, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Dual disorders and suicide during and following the COVID-19 pandemic |
Sher, L |
Acta Neuropsychiatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Shutt, J, Liddle, et al |
Local Economy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
IoMT Potential Impact in COVID-19: Combating a Pandemic with Innovation |
Siddiqui, MF |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Simpson, Amelia |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mechanistic basis and therapeutic relevance of hypocalcemia during severe COVID-19
infection |
Singh, VP, Khatua, et al |
Endocrine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sivanandan, S, Chawla, et al |
Indian Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Online portal-based system for improving patient-generated photographs for teledermatology |
Su, MY, Trefrey, et al |
Dermatol Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Alcohol and COVID-19: How Do We Respond to This Growing Public Health Crisis? |
Sugarman, DE, Greenfield, et al |
J Gen Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Suh, EH, Bodnar, et al |
Emerg Med J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Best Practices for COVID-19-Positive or Exposed Mothers-Breastfeeding and
Pumping Milk |
Sullivan, SE, Thompson, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
No Community Left Behind: A Call for Action During the COVID-19 Pandemic |
Sullivan, SR, Bell, et al |
Psychiatr Serv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Treating COVID-19: are we missing out the window of opportunity? |
Sundararaj Stanleyraj, J, Sethuraman, et al |
J Antimicrob Chemother |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Another Look at Privacy-Preserving Automated Contact Tracing |
Tang, Qiang |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 Vaccines on Clinical Trials and their Mode of Action for Immunity
against the Virus |
Tavakol, S, Alavijeh, et al |
Curr Pharm Des |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 Insightful Data Visualization and Forecasting Using Elasticsearch |
Tewtia, HK, Singh, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Thompson, AD, Lindstrom, et al |
Journal of Digital Learning in Teacher Education |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Health Product Promotional Violations During the COVID-19 Pandemic: Return of Snake Oil
Medicine |
Tran, Allan, Sheikhan, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tripathi, MK, Sharma, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Udelson, JE, Curtis, et al |
JAMA Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Umeda-Raffa, S, Pergolizzi, et al |
J Clin Pharm Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Valensisi, G |
European Journal of Development Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
van der Vegt, I, Kleinberg, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Verma, S, Gazara, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Viswanath, K, Lee, et al |
Health Commun |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Australian university and medical school life during the 1919 influenza pandemic |
Waghorne, J |
History of Education Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wenzel, K, Fishman, et al |
Journal of substance abuse treatment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Winstanley, EL, Lander, et al |
J Addict Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Positive outcomes of COVID-19 research-related gender
policy changes |
Witteman, HollyO, Haverfield, et al |
bioRxiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wiwanitkit, V |
Urol Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Que peuvent apprendre les pays de la réponse de Hong Kong à la pandémie de COVID-19? |
Wong, SYS, Kwok, et al |
Cmaj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wu, C, Glass, et al |
Infect Control Hosp Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Wu, K |
Etnografia e Ricerca Qualitativa |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ye, S, Kronish, et al |
J Gen Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yu, X |
Acta Paediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7577862; Energy access and pandemic-resilient livelihoods: The role of solar
energy safety nets |
Zaman, R, van Vliet, et al |
Energy Res Soc Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19: Spatial Dynamics and Diffusion Factors across Russian Regions |
Zemtsov, SP, Baburin, et al |
Regional Research of Russia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zhan, MJ, Huang, et al |
Forensic Sci Med Pathol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The development of a quarantine strategy is an important path to a normalized response
to COVID-19 |
Zhu, H, Lu, et al |
Biosci Trends |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Additional Concerns Regarding Children With Coronavirus Disease 2019 |
Zimmermann, P, Goetzinger, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
2020 Transnational
Engineering Education using Technology, TREET 2020 |
|
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Am J Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Am J Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
NewsCAP: New U.S. cancer diagnoses plummeted with the onset of COVID-19 |
|
Am J Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Am J Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
12th International Conference on Social
Informatics, SocInfo 2020 |
|
|
Commentary/Editorial| Commentaire/Éditorial |
|
Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives