Good afternoon,
There are 895 citations in today’s scan. 467 were considered primary research or review literature.
Highlights today include:
CANADA
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Good and Hawkes, developed a system of ordinary differential equations to describe SARS-CoV-2 epidemic with waning immunity for the province of Alberta. They show how immunity
may work with current social practices to limit the spread of the virus. The number of deaths after 3 years was predicted to be 51,000 with rapidly waning immunity, compared to 11,000 if immunity waned more slowly over 1 year, and 6,300 if permanent immunity
was assumed. They further show that a vaccine that is 50% effective and taken by 50% of the population will prevent further loss of life, providing that social distancing is still practiced and that immunity does not wane quickly.
·
Leigh et al.
assessed self-reported public perceptions, knowledge, and behaviours related to COVID-19 to understand perspectives in Canada using a cross-sectional survey of 1,996 Canadians. There was high compliance with distancing
measures (80% reported self-isolating or always physical distancing) and 75.8% of respondents reported that they would get vaccinated for the virus when a vaccine became available.
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Moyles et al.
presented a mathematical model where the decision to increase or decrease social distancing is modelled dynamically as a function of the measured active and total cases and the perceived cost of isolating. The results are compared to case data in Ontario,
Canada, from March to August 2020. The authors observed that minimum costs are not always associated with increased spending and increased vigilance, which is due to the desire for people not to distance and the fatigue they experience.
PUBLIC HEALTH INTERVENTION
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Garrido et al., present a mathematical SEIR model focused on analysing the transmission dynamics of COVID-19, the patients circulating in the hospitals
and evaluating the effects of health policies and vaccination on the control of the pandemic. The results show that: 1) infected will increase until 5.6% - 7.4% of the total population over next 3-4 months, 2) vaccination seems not to be enough to face the
pandemic and other strategies should be used; 3) we also support the claim of the WHO about the effectiveness of the vaccine, that should be, at least, of 50% to represent a substantial progress against the COVID-19; 4) after the 2nd wave, the return to normal
life should be controlled and gradual to avoid a 3rd wave.
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Hernández-Orallo et al.,.This
paper evaluates the effectiveness of recently developed contact tracing smartphone applications for COVID-19 that rely on Bluetooth to detect contacts. Results show that smartphone contact tracing can only be effective when combined with other mild measures
that can slightly reduce the reproductive number (R0) (for example, social distancing).
TRANSMISSION
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Prentiss, et al
study transmission of COVID-19 using five well-documented case studies: a Washington state church choir, a Korean call center, a Korean exercise class, and two different Chinese bus trips. An estimate of N 0, the characteristic number of COVID-19 virions
needed to induce infection in each case, is found using a simple physical model of airborne transmission. We find that the N 0 values are similar for five COVID-19 superspreading cases (~300-2,000 viral copies) and of the same order as influenza A.
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Aydin et al.
studied the falling dynamics and velocity in calm air of SARS-CoV-2 with or without a respiratory water droplet of 1 to 2000 micrometers (µm) in diameter from an infected person of 0.5 to 2.6 m in height. The horizontal distance travelled by SARS-CoV-2
in free fall from 1.7 m was 0.88 m due to breathing or talking and 2.94 m due to sneezing or coughing. Large droplets > 100 µm reached the ground from 1.7 m in less than 1.6 s, while the droplets ≥ 30 µm fell within 4.42 s regardless of the human height.
IMMUNOLOGY
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Bilich et al
shows the longitudinal analysis of SARS-CoV-2 immunity in convalescents up to six months post-infection. They revealed decreasing and stable spike and nucleocapsid antibody responses, respectively. In contrast, T cell responses remained robust and even
increased in frequency and intensity. Single epitope mapping of T cell diversity over time identified ORF-independent, dominant T cell epitopes mediating long-term SARS-CoV-2 T cell responses and may be fundamental for vaccine design.
EPIDEMIOLOGY
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Zhou et al investigated the association between ambient air pollutants, meteorological factors and their interaction on confirmed case counts of COVID-19
in 120 Chinese cities. Positive associations were found between the number of confirmed cases of COVID-19 and carbon monoxide, aerodynamic particulate matter with aerodynamic diameter ≤2.5 µm, relative humidity and ozone, with and without migration scale index
(MSI)-adjustment. Negative associations were also found for sulfur dioxide and wind velocity both with and without controlling for population migration. In addition, air pollutants and meteorological factors had interactive effects on COVID-19 after controlling
for MSI.
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Roy et al.
use datasets on US states to create an integrated dataset of potential factors leading to the pandemic spread; and carry out regression analysis to pinpoint the key pre-lockdown factors that affect post-lockdown infection and mortality. Population density,
testing numbers and airport traffic emerge as the most discriminatory factors, followed by higher age groups (above 40 and specifically 60+). Post-lockdown infected and death rates are highly influenced by their pre-lockdown counterparts, followed by population
density and airport traffic. Mortality rate seems to be driven by individual physiology, preexisting condition, age etc., rather than gender, healthcare facility or ethnic predisposition.
CLINICAL DATA
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Viola et al
studied the prevalence of subjective tinnitus and dizziness in a sample of COVID-19 patients in Italy. Thirty-four patients (18.4%) reported equilibrium disorders after COVID-19 diagnosis. Of these, 32 patients reported dizziness (94.1%) and 2 (5.9%)
reported acute vertigo attacks. Forty-three patients (23.2%) reported tinnitus; 14 (7.6%) reported both tinnitus and equilibrium disorders.
VACCINE RESEARCH
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Rauch, et al
show preclinical data for our clinical candidate CVnCoV, a lipid nanoparticle (LNP) encapsulated non-modified mRNA vaccine that encodes the full length, pre-fusion stabilised SARS-CoV-2 Spike (S) protein. Immunisation with CVnCoV induced strong humoral
responses with high titres of virus neutralizing antibodies in mice and hamsters and robust CD4+ and CD8+ T cell responses in mice. Most importantly, vaccination with CVnCoV fully protected hamster lungs from challenge with wild type SARS-CoV-2.
CORONAVIROLOGY
·
Rahman et al.
explored 61,485 sequences of the nucleocapsid (N) protein, a potent diagnostic and prophylactic target, for identifying the mutations to review their roles in real‐timePCR based diagnosis and observe consequent impacts. The N protein of SARS‐CoV‐2 comprises
an average of 1.2 mutations per strain compared to 4.4 and 0.4 in MERS‐CoV and SARS‐CoV, respectively. The high frequency (67.94% of mutated sequences) co‐occuring mutations destabilized and decreased overall structural flexibility of the N-protein.
DIAGNOSTICS
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Majeed et al aimed to determine the diagnostic accuracy in terms of sensitivity and specificity of CT chest in diagnosing and confirming COVID-19 infection in patients presenting
with acute surgical and medical pathologies a UK hospital. Sensitivity of CT scan to diagnose COVID-19 infection was found to be 58% whilst specificity was 73% with a negative predictive value of 77.69%. With a negative predictive value of up to 82.4%, CT
thorax can play an important role to help surgeons in their decision making for asymptomatic suspected cases of COVID-19.
·
Tan et al
evaluated and compared six SARS-CoV-2 serology kits including the Abbott SARS-CoV-2 IgG assay, Beckman Access SARS-CoV-2 IgG assay, OCD Vitros OCD Anti-SARS-CoV-2 Total antibody assay, Roche Elecsys Anti SARS-CoV-2 assay, Siemens SARS-CoV-2 Total assay,
and cPass surrogate viral neutralising antibody assay. All assays exhibited excellent specificity and total antibody assays with spike protein configurations generally outperformed nucleocapsid configurations and IgG assays in terms of diagnostic sensitivity.
HEALTHCARE RESPONSE
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Lieu et al. used a quasi-experimental (before and after) intervention strategy, with 151 first-line nurses in Wuhan, China to assess
the effectiveness of diaphragmatic breathing relaxation training for improving sleep quality among nursing staff during the COVID-19 outbreak. Participant nurses achieved significant reductions in global sleep quality, subjective sleep quality, sleep latency,
sleep duration, sleep disturbance, habitual sleep efficiency, daytime dysfunction, and anxiety.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura
Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Bronchoalveolar lavage-based COVID-19 testing in patients with cancer |
Abid, MB, Chhabra, et al |
Hematology/ Oncology and Stem Cell Therapy |
Clinical data| Données cliniques |
Three of five immunocompromised patients, identified as COVID-19 positive at the Medical College of Wisconsin, were
not detected by nasopharyngeal swab sampling. Due to high clinical suspicion for COVID-19 three underwent bronchoalveolar lavage specimen testing and returned positive results. Two patients had better outcomes that could be attributed to earlier BAL specimen
testing resulting in timely medical intervention. |
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33007327; Severe SARS-CoV-2 disease in the context of a NF-κB2 loss-of-function pathogenic variant |
Abraham, RS, Marshall, et al |
Journal of Allergy and Clinical Immunology |
Clinical data| Données cliniques Immunology | Immunologie |
Described is the clinical management of SARS-CoV-2 infection in a 17 year old male with a novel nuclear factor kB2 loss of function variant. He recovered
from the infection after receiving biologic therapies to avert potentially fatal acute respiratory distress syndrome and treat hyperinflammatory responses. |
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The Impact of the COVID-19 Outbreak on the Socio-Economic Issues of the Black Sea Region Countries |
Abuselidze, G, Mamaladze, et al |
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Economics | Économie |
The aim of the research is to study the impact of the current pandemic situation on the socio-economic issues of the Black Sea Region countries. The results
presented in the study and the recommendations developed based on the research have a practical purpose in eliminating the Pandeconomic crisis |
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Oral covid-19 disclosing test: A novel rapid technique in infection diagnosis |
Addi, RA, Benksim, et al |
Open Public Health Journal |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Propose a new test technique based on the use of oral gel, mouthwash, or tablets that color the area where the virus is localized in mouth, to diagnose
the COVID-19 infection. |
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Afrasiabi, Ali, Alinejad-Rokny, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We analyzed the sequences of a wide range of viruses using both alignment-based and alignment free approaches to investigate the origin of SARS-CoV-2 genome.
Our analyses revealed a high level of similarity between the ACE@-binding domain and the 5UTR of SARS-CoV-2 and that of a Guangdong pangolin coronavirus. In addition, the low CpG abundance in SARS-CoV-2 is not related to an evolutionary pressure exerted by
the host antiviral protein ZAP. |
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Agbata, BC, Emmanuel, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions de santé publique |
In this article, we formulated a mathematical model for the spread of the COVID-19 disease in Nigeria. The study shows
that isolation, quarantine and other government policies like social distancing and lockdown are the best approaches to control the pernicious nature of COVID-19 pandemic. |
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Ahmadi, Amirhossein, Moradi, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
The aim of this study is to analyze if enoxacin can exert anti-SARS-CoV-2 effects. We exploit multiple computational
tools and databases to examine (i) whether the RNAi mechanism, as the target pathway of enoxacin, could act on the SARS-CoV-2 genome, and (ii) microRNAs induced by enoxacin might directly silence viral components as well as the host cell proteins mediating
the viral entry and replication. We find that the RNA genome of SARS-CoV-2 is a suitable substrate for DICER activity. We also highlight several enoxacin-enhanced microRNAs which could target SARS-CoV-2 components, pro-inflammatory cytokines, host cell components
facilitating viral replication, and transcription factors enriched in lung stem cells, thereby promoting their differentiation and lung regeneration. Finally, our analyses identify several enoxacin-targeted regulatory modules that were critically associated
with exacerbation of the SARS-CoV-2 infection. Overall, our analysis suggests that enoxacin could be a promising candidate for COVID-19 treatment through enhancing the RNAi pathway. |
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Alamdari, NM, Rahimi, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to assess the impact of MetS (metabolic syndrome) on morbidity and mortality among COVID-19 patients in Shahid
Modarres Hospital in Tehran. MetS components waist circumference (OR=8.31;p-value<0.0001) and fasting blood sugar (OR=2.4588;p-value=0.0245) were independent prognostic factors for mortality. The findings suggest a strong relationship between having MetS
and increased risk of severe complications and mortality among COVID-19 ICU-admitted patients. |
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Al-Ghafry, M, Aygun, et al |
Pediatr Blood Cancer |
Clinical data| Données cliniques |
The hypercoagulable state in adults, correlated with elevations in maximum clot firmness (MCF) abd rotational thromboelastometry
(ROTEM), is a strong predictor of mortality. We report our experience in children infected with SARS-CoV-2, with noted elevations in D-dimer and MCF on ROTEM (indicating hypercoagulability). Exploration of viscoelastic testing to provide additional laboratory-based
evidence for pediatric-specific risk assessment for thromboprophylaxis in SARS-CoV-2 is warranted. |
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Alhashash, M, Elsebaiy, et al |
Eur Spine J |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The current COVID-19 pandemic requires an extra-ordinary organization of the medical and surgical care of the patients.
It is possible to manage an infected or a potentially infected patient surgically, but a multidisciplinary plan is necessary to protect other patients and the medical staff. |
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Chronic Lymphocytic Leukemia Concomitant with COVID 19: A Case Report |
Ali, E, Badawi, et al |
Am J Case Rep |
Clinical data| Données cliniques |
A 49-year-old man with no significant previous illnesses presented with a moderate COVID-19 infection, fever and mild
shortness of breath. A complete blood count showed a high white blood cell count with absolute lymphocytosis. Flow cytometry revealed the clonality of the lymphocytes confirming the diagnosis of CLL. Lymphocytosis is an unexpected finding in patients diagnosed
with COVID-19 infection. |
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Alpalhão, M, Gaibino, et al |
Int J Dermatol |
Clinical data| Données cliniques |
A 63‐year‐old Caucasian male, Fitzpatrick III phototype, who was admitted to the Intensive Care Unit (ICU) due to a
severe coronavirus disease 2019 (COVID‐19) pneumonia. At day 33, the patient developed a nonpruriginous erythematosquamous dermatosis localized in the face, affecting the forehead, supraciliary regions, and nasolabial folds, with outward extension to both
cheeks . |
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Altalhi, TA, Alswat, et al |
Journal of Molecular Structure |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, we investigate the possible binding mechanism of ClQ and ClQOH with sialic acid both in the gas phase and in
water using density functional theory (DFT). We investigated the binding of the neutral, monoprotonated and diprotonated ClQs and ClQOHs to sialic acid to simulate the pH effect on the cellular receptor binding. DFT results reveals that monoprotonated ClQ+
and ClQOH+, which account for more than 66% in the solution, possess high reactivity and binding towards sialic acid. The Neu5Ac-ClQ and the analogues Neu5Ac-ClQOH adducts were stabilized in water than in the gas phase. The molecular complexes stabilize by
strong hydrogen bonding and π - π stacking forces. In addition, proton-transfer in Neu5Ac-ClQOH+ provides more stabilizing power and cellular recognition binding forces. These results shed light on possible recognition mechanism and help future breakthroughs
for COVID-19 inhibitors. |
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Álvarez Fernández, M, Armando Meléndez, et al |
Medicina Intensiva |
Clinical data| Données cliniques |
Article in Italian. Patient presents with symptoms compatible with SAR CoV-2. Some radiography is done. |
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Álvarez Nonay, A, Cabia Fernández, et al |
Medicina clinica |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
A retrospective descriptive study of in-hospital drugs dispensed and administered to patients with SARS-CoV-2 infection
in Aragon, Spain. Data from 1,482 patients admitted with confirmed infection (60% of hospitalized COVID-19 patients) were analyzed: 813 (54.9%) men and 669 (45.1%) women, with a median age of 75 years IQR (62 -85). 456 different active ingredients were prescribed,
with a median of 13 active ingredients per patient (IQR 9-19). 73% (1,093) of patients received hydroxychloroquine, lopinavir / ritonavir, or azithromycin. 48% of patients received an immunosuppressive treatment. with 84% of these patients receiving methylprednisolone
and 8.7% dexamethasone. |
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Ansari, MA, Jamal, et al |
Arabian Journal of Chemistry |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The current study focuses on the molecular docking analysis of TAT-peptide47–57 (GRKKRRQRRRP)-conjugated repurposed
drugs (i.e., lopinavir, ritonavir, favipiravir, and hydroxychloroquine) with SARS-CoV-2 main protease (3CLpro) to discover potential efficacy of TAT-peptide (TP) - conjugated repurposing drugs against SARS-CoV-2. The molecular docking results validated that
TP-conjugated ritonavir, lopinavir, favipiravir, and hydroxychloroquine have superior and significantly enhanced interactions with the target SARS-CoV-2 main protease. In-silico approach employed in this study suggests that the combination of the drug with
TP is an excellent alternative to develop a novel drug for the treatment of SARS-CoV-2 infected patients. |
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Apostolou, M, Kagialis, et al |
Mankind Quarterly |
Public Health response| Interventions de santé publique |
The current research examines the impact of the coronavirus disease outbreak on emotional welfare and the moderating
impact of relationship status in the Greek cultural context. We found that participants were more likely to experience severe and extremely severe instances of depression, anxiety and stress after than before the outbreak. We also found that the COVID-19 outbreak
was associated with lower life satisfaction. However, the effects were small. With respect to relationship status, we found that participants who were involuntarily single experienced more negative emotions and lower life satisfaction than those who preferred
to be single, those who were between relationships, and those who were in an intimate relationship. No significant interaction between the COVID-19 outbreak and relationship status was found, suggesting that the impact of the outbreak on emotional well-being
was similar in those who were single and in those who were in a relationship. |
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Applebaum, JW, Tomlinson, et al |
Animals |
Public Health response| Interventions de santé publique |
We conducted a large-scale survey of U.S. pet owners (n = 2254) in spring and summer 2020 to assess the ways that relationships
with pets impacted life during COVID-19. We used thematic analysis to analyze 3671 open-ended responses to three prompts. Reported concerns fell into three major categories: (1) pet-focused (meeting needs of pets; procuring supplies; accessing veterinary care;
new and emerging behavioral issues; fate of the pet if owner becomes ill; general safety and well-being), (2) human-focused (issues with working from home; well-being and mental health; balancing responsibilities), and (3) household-focused (disease spread;
economic issues). Quantitative analyses showed that the owner’s strength of attachment to their pet, economic resources, and relationship status were associated with the types of concerns expressed. Results from this study indicate that pet owners experienced
unique hardships related to changes in everyday life from the COVID-19 pandemic. These hardships should be considered alongside the potential benefits found in other studies in order to manage pet owner expectations, prevent pet relinquishment, and more fully
understand multifaceted human-companion animal relationships. |
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32987040; Type 1 diabetes and COVID-19: The “lockdown effect” |
Aragona, M, Rodia, et al |
Diabetes research and clinical practice |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
The aim of this study was to evaluate the effect the lockdown imposed during COVID-19 outbreak on the glycemic control
of people with Type 1 diabetes (T1D) using Continuous (CGM) or Flash Glucose Monitoring (FGM). We retrospectively analyzed glucose reading obtained by FGM or CGM in T1D subjects. Sensor data from 2 weeks before the lockdown (Period 0, P0), 2 weeks immediately
after the lockdown (period 1, P1), in mid-lockdown (Period 2, P2) and immediately after end of lockdown (Period 3, P3) were analyzed. The study included 63 T1D patients, (FGM: 52, 82%; CGM:11, 18%). Sensor use (91%) were slightly reduced. Despite this reduction,
Time in Range increased in P1 (62%), P2 (61%) and P3 (62%) as compared to P0 (58%, all p < 0.05 or less) with concomitant reduction in the Time Above Range (P0: 38%; P1: 34%, P2: 34%, P3: 32%, all p < 0.05 or less vs. P0). In T1D subjects with good glycemic
control on CGM or FGM, the lockdown had no negative impact. Rather a modest but significant improvement in glycemic control has been recorded, most likely reflecting more regular daily life activities and reduces work-related distress |
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A spatial-temporal model for the evolution of the COVID-19 pandemic in spain including mobility |
Aràndiga, F, Baeza, et al |
Mathematics |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
In this work, a model for the simulation of infectious disease outbreaks including mobility data is presented. The
model is based on the SAIR compartmental model and includes mobility data terms that model the flow of people between different regions. The aim of the model is to analyze the influence of mobility on the evolution of a disease after a lockdown period and
to study the appearance of small epidemic outbreaks due to the so-called imported cases. We apply the model to the simulation of the COVID-19 in the various areas of Spain, for which the authorities made available mobility data based on the position of cell
phones. We also introduce a method for the estimation of incomplete mobility data. Some numerical experiments show the importance of data completion and indicate that the model is able to qualitatively simulate the spread tendencies of small outbreaks. |
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Ardabili, Sina, Mosavi, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The present study aims to engage an artificial neural network-integrated by grey wolf optimizer for COVID-19 outbreak
predictions by employing the Global dataset. Training and testing processes have been performed by time-series data related to January 22 to September 15, 2020 and validation has been performed by time-series data related to September 16 to October 15, 2020.
Results have been evaluated by employing mean absolute percentage error (MAPE) and correlation coefficient (r) values. ANN-GWO provided a MAPE of 6.23, 13.15 and 11.4% for training, testing and validating phases, respectively. According to the results, the
developed model could successfully cope with the prediction task. |
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Impact of lockdown on particulate matter concentrations in Colombia during the COVID-19
pandemic |
Arregocés, HA, Rojano, et al |
Science of the Total Environment |
Public health interventions*| Interventions de santé publique |
The objective of this study is to evaluate the impact of the lockdown due to the COVID-19 pandemic on PM2.5 concentrations
at 5 monitoring stations in Columbia and aerosol optical depth values of the Terra/MODIS satellite. We analyzed and compared the weekly and monthly concentrations of PM2.5 before and during the lockdown between the week of January 6 to June 22, 2020, and compared
the daily values obtained from the Terra/MODIS satellite for the months of January–June during the years 2018–2020 to elucidate the effects of the lockdown. Similar to other monitored sites in the world, we observed substantial reductions in weekly PM2.5 concentrations,
from 41 to 84% (Bogotá), from 13 to 66% (Funza), from 17 to 57% (Boyacá), from 35 to 86% (Valledupar) and 31 at 60% (Risaralda). Unlike other studies, the aerosol optical depth values increased up to 59% during the months of lockdown compared to previous years
and up to 70% of the weekly mean when compared to before the lockdown. These spatiotemporal behaviors of PM2.5 and the aerosol optical depth in Colombia are influenced by reductions in vehicular flow during quarantine, regional rainfall, and height of the
planetary boundary layer. Emissions from economic activities affect pollutant levels in the area. The analysis of the levels of pollutants during the lockdown provides a baseline for regulatory agencies to establish mitigation plans. |
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Asadzandi, M, Abolghasemi, et al |
Journal of Military Medicine |
Public Health response| Interventions de santé publique |
The aim of this study was to comparatively evaluate the spiritual health behaviors of the Iranian Muslim in the COVID-19
pandemic with religious evidence. This study was conducted in the period from March 1, 2020, to the end of May 2020 in Tehran, Iran. Without intervening in the research samples, the researchers observed, recorded, examined and compared their individual and
social behaviors with religious evidence. Data collection methods were semi-structured interviews, observation, taking notes from published papers, website surveys and social networks. Religious beliefs, as a moral motivating factor, had a positive effect
on the health behaviors and spiritual health of people in the biological crisis of the COVID-19 pandemic. |
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Ashoor, Dana, Ben Khalaf, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We herein report a computational study on the implications of SARS-CoV-2 RBD mutations and the Angiotensin Converting
Enzyme 2 (ACE2) receptor genetic variations on the stability of the virus-host association. In silico analysis of the complex between the virus mutated forms and ACE2 isoform 1 showed that out of 351 RBD point mutations, 83% destabilizes the complex, while
17% have mild stabilizing effect. Study of the complex SARS-CoV-2 Wuhan strain RBD region /ACE2 isoform 1, 6LZG PDB 3D model revealed 18 contact residues. Interestingly, mutations occurring in 15 out of these residues show variations in the patterns of polar
and hydrophobic interactions as compared to the original complex. Similarly, comparison of the effect on the complex stability of different ACE2 variants showed that the pattern of molecular interactions and the virus-receptor complex stability varies also
according to ACE2 polymorphism. This could explain the large inter-individual variation of disease susceptibility and/or severity. The observation of a high variability in the interactions patterns highlights the complexity of the molecular interplay between
SARS-CoV-2 and the ACE2 receptor. We infer that it is important to consider both ACE2 genetic variants and SARS-CoV-2 RBD mutations to assess the stability of the virus-receptor association and evaluate the infectivity of circulating SARS-CoV-2. |
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Health Vulnerability versus Economic Resilience to the COVID-19 pandemic: Global Evidence |
Asongu, Simplice, Diop, et al |
SSRN- Lancet prepublication |
Economics | Économie |
The purpose of this study is to understand how countries have leveraged on their economic resilience to fight the COVID-19
pandemic. The focus is on a global sample of 150 countries divided into four main regions, namely: Africa, Asia-Pacific and the Middle East, America and Europe. The study develops a health vulnerability index (HVI) and leverages on an existing economic resilience
index (ERI) to provide four main scenarios from which to understand the problem statement, namely: ‘low HVI-low ERI’, ‘high HVI-low ERI’, ‘high HVI-high ERI’ and ‘low HVI-high ERI’ quadrants. It is assumed that countries that have robustly fought the pandemic
are those in the ‘low HVI-high ERI’ quadrant and to a less extent, countries in the ‘low HVI-low ERI’ quadrant. Most European countries, one African country (i.e. Rwanda), four Asian countries (Japan, China, South Korea and Thailand) and six American countries
(USA, Canada, Uruguay, Panama, Argentina and Costa Rica) are apparent in the ideal quadrant. |
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Atay, S, Cura, et al |
Wound management & prevention |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to further examine PPE-related physical problems experienced by nurses as well as the
role of wear time on these problems. Using a descriptive cross-sectional design, a survey was conducted among nurses working for state or university hospitals across Turkey who actively cared for patients with COVID-19. Three hundred and seven (307) nurses
completed the survey. The most commonly reported problems were sweating when wearing a surgical (50.9%) or N95 (64.2%) mask, dry hands from wearing gloves (73.9%), perspiration when wearing overalls/gowns (84.1%), and vision problems when wearing goggles/face
shields (47.9%). The results of this study show that physical problems related to the use of PPE are common and increase when PPE is worn for more than 4 hours. |
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Falling Dynamics of SARS-CoV-2 as a Function of Respiratory Droplet Size and Human Height |
Aydin, M, Evrendilek, et al |
Journal of Medical and Biological Engineering |
Transmission Coronavirology| Coronavirologie |
The purpose of this study is to quantify the motion dynamics of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2). Three physical models of Newton’s and Stokes’s laws with(out) air resistance in the calm air are used to determine the falling time and velocity regimes of SARS-CoV-2 with(out) a respiratory water droplet of 1 to 2000 micrometers (µm) in diameter
of an infected person of 0.5 to 2.6 m in height. The horizontal distance travelled by SARS-CoV-2 in free fall from 1.7 m was 0.88 m due to breathing or talking and 2.94 m due to sneezing or coughing. According to Newton’s laws of motion with air resistance,
its falling velocity and time from 1.7 m were estimated at 3.95 × 10−2 m s−1 and 43 s, respectively. Large droplets > 100 µm reached the ground from 1.7 m in less than 1.6 s, while the droplets ≥ 30 µm fell within 4.42 s regardless of the human height. Based
on Stokes’s law, the falling time of the droplets encapsulating SARS-CoV-2 ranged from 4.26 × 10−3 to 8.83 × 104 s as a function of the droplet size and height. The spread dynamics of the COVID-19 pandemic is closely coupled to the falling dynamics of SARS-CoV-2
for which Newton’s and Stokes’s laws appeared to be applicable mostly to the respiratory droplet size ≥ 237.5 µm and ≤ 237.5 µm, respectively. |
|
Azmy, V, Benson, et al |
Ann Allergy Asthma Immunol |
Clinical data| Données cliniques |
We present a case of suspected idiopathic nonhistaminergic acquired angioedema (InH-AAE) in a young woman with COVID-19.
She had normal C4, C1 esterase inhibitor protein level and function, C1q, and no response to antihistamines or corticosteroids. With normal laboratory results and lack of family history, hereditary angioedema was effectively ruled out. She did not have urticaria
or other features of immediate hypersensitivity reactions, such as an elevated tryptase. Drug reactions were considered, but delayed hypersensitivity reactions to hydroxychloroquine involving urticaria and angioedema are quite rare and would likely improve
with antihistamines and corticosteroids. It is possible that InH-AAE is another manifestation of the hyperimmune response to SARS-CoV-2 and should be considered in patients who receive a diagnosis of angioedema without urticaria, which is nonresponsive to
antihistamines or corticosteroids. |
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SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses |
Banerjee, AK, Blanco, et al |
Cell |
Coronavirology| Coronavirologie |
We comprehensively define the interactions between SARS-CoV-2 proteins and human RNAs. NSP16 binds to the mRNA recognition
domains of the U1 and U2 splicing RNAs and acts to suppress global mRNA splicing upon SARS-CoV-2 infection. NSP1 binds to 18S ribosomal RNA in the mRNA entry channel of the ribosome and leads to global inhibition of mRNA translation upon infection. Finally,
NSP8 and NSP9 bind to the 7SL RNA in the signal recognition particle and interfere with protein trafficking to the cell membrane upon infection. Disruption of each of these essential cellular functions acts to suppress the interferon response to viral infection.
Our results uncover a multipronged strategy utilized by SARS-CoV-2 to antagonize essential cellular processes to suppress host defenses. |
|
Banke-Thomas, A, Chigozie Makwe, et al |
Int J Gynaecol Obstet |
Public Health response| Interventions de santé publique Economics | Économie |
To estimate utilization cost of spontaneous vaginal delivery (SVD) and caesarean delivery (CD) for pregnant women with
Coronavirus Disease (COVID-19) at the largest teaching hospital in Lagos, the pandemic's epicenter in Nigeria. We collected facility-based and household costs of all nine pregnant women with COVID-19 managed at the hospital. We compared their mean facility-based
costs with those paid by pregnant women pre-COVID-19, identifying cost-drivers. We also estimated what would have been paid without subsidies, testing assumptions with a sensitivity analysis. Total utilization cost ranged from US$494 for SVD with mild COVID-19
to US$4,553 for emergency CD with severe COVID-19. Though 32-66% of facility-based cost were subsidized, cost of SVD and CD during the pandemic have doubled and tripled respectively compared to those paid pre-COVID. Despite cost exemptions and donations, utilization
costs remain prohibitive. Regulation of PPE and medical oxygen supply chains and expansion of advocacy for health insurance enrolments are needed to minimize catastrophic health expenditure. |
|
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Barattucci, M, Chirico, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
This study investigated the mechanisms underlying online health information-seeking behavior and people’s complaints
toward the government’s restrictions (GR) during a COVID-19 emergency in the Italian population. Sociodemographic and cognitive factors predicted the participants’ affect and anxiety, which, in turn, motivated and fully mediated both information search behavior
and complaint toward GR. This research can offer useful suggestions for policy-makers during the COVID-19 emergency, and it advanced the knowledge on the risk–emotion link in emergency situations. |
|
|
Bartoli, M, Palermo, et al |
Frontiers in Psychology |
Clinical data| Données cliniques |
We present an unusual case of a woman affected by a combined polar and paramedian bilateral thalamic infarction. The
patient underwent an extensive neuropsychological evaluation to assess cognitive, behavioral, and functional domains, with a focus on executive functions. She was assessed clinically in the acute phase and after 6 months from the stroke, both clinically and
by magnetic resonance imaging. The patient developed a cognitive impairment, characterised by prevalent executive dysfunction associated with reduced self-awareness and mood changes, in terms of apathy and depression. Such condition persisted after 6 months.
In May 2020, the patient underwent the serology test in chemiluminescence to detect IgG antibodies against SARS-CoV-2. The result of the quantitative test highlighted a high probability of previous contact with the virus. We suggest that reduced self-awareness
related to executive dysfunction and behavioral changes may be due to combined polar and paramedian bilateral thalamic lesion. Metacognitive–executive dysfunction affecting the instrumental abilities of everyday life might make people less able to take appropriate
precautions, facilitating the risk of SARS-CoV-2 contagion. |
|
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Barwais, FA |
Open Public Health Journal |
Public Health response| Interventions de santé publique |
This study aimed to assess levels of physical activity among Saudi participants before and during the COVID-19 pandemic.
The study included 244 young and middle-aged Saudi adults (154 males, 90 females), (mean age ± SD, 33.8 ± 7.7 years). All subjects completed an online self-report questionnaire to determine their physical activity levels over the last 7 days. A significant
decrease (57.1%) in the time spent performing physical activity before and during the COVID-19 lockdown was observed. No significant difference in total MET-min/week of physical activity before and during the lockdown was observed for the participants who
participated in physical activity with a personal trainer (before = 2207 ± 389.3 MET-min/week; during = 2077 ± 201.5 MET-min/week). However, results indicated significant decreases in physical activity for participants who performed physical activity alone
(59%), with family (61.6%), with friends (62%), or with groups (61.3%). |
|
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Reversible splenial lesion syndrome associated with SARS-CoV-2 infection in two children |
Bektaş, G, Akçay, et al |
Brain and Development |
Clinical data| Données cliniques |
We report two children with multisystem inflammatory syndrome-children related to SARS-CoV-2 who developed reversible
splenial lesion syndrome (RESLES) during the disease course. Encephalopathy was the main central nervous system symptom. Both of the children showed a rapid recovery, and brain magnetic resonance imaging revealed complete resolution of the splenial lesion
within 1 week. The complete resolution of the splenial lesion and rapid recovery from encephalopathy in RESLES associated with SARS CoV-2 were similar to observed in MERS. |
|
Belenguer Muncharaz, A, Hernández-Garcés, et al |
Medicina Intensiva |
Clinical data| Données cliniques |
Article in Spanish. We present our series of 27 patients admitted to the Intensive Medicine Service (ICS) between March-May
2020: 21 received NIV, five received IMV, and one patient received ONAF (no IMV required). |
|
|
Bengio, Yoshua, Gupta, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
In this paper, we use a recently-proposed COVID-19 epidemiological simulator to develop and test methods that can be
deployed to a smartphone to locally and proactively predict an individual's infectiousness (risk of infecting others) based on their contact history and other information, while respecting strong privacy constraints. Predictions are used to provide personalized
recommendations to the individual via an app, as well as to send anonymized messages to the individual's contacts, who use this information to better predict their own infectiousness, an approach we call proactive contact tracing (PCT). We find a deep-learning
based PCT method which improves over binary contact tracing (BCT) for equivalent average mobility, suggesting PCT could help in safe re-opening and second-wave prevention. |
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How societal responses to COVID-19 could contribute to child neglect |
Bérubé, A, Clément, et al |
Child Abuse and Neglect |
Public Health response| Interventions de santé publique |
Objective: The purpose of this study is to examine parents’ reports on the response their children received to their
needs during the COVID-19 crisis. Methods: During the period of the spring 2020 lockdown, 414 parents in the province of Quebec, Canada, completed an online questionnaire about the impact of the crisis on the response their children received to their needs.
Results: Compared to parents of younger children, parents of older children reported less fulfillment of their child's needs in three measured domains, namely cognitive and affective, security, and basic care needs. |
|
Bich-Ngoc, N, Teller, et al |
Water (Switzerland) |
Public Health response| Interventions de santé publique |
Using Liège as a case study, this study aims to address the potential effect of outbound tourism on water consumption
and how the current COVID-19 pandemic might affect the total water demand. Statistical models were developed and validated using the total daily volume of 23 municipalities in the Liège conurbation, the monthly total number of outbound trips, and other meteorological
data. Results suggest significantly lower water demand in the months with high numbers of outbound travel activities. Though the projected risk of increased water needs due to fewer people traveling is moderate, the threat becomes much higher during long periods
of dry and hot weather. |
|
|
Bilal, Usama, Barber, et al |
medRxiv |
Epidemiology| Épidémiologie |
We explored the emergence of spatial inequities in COVID-19 testing, positivity, incidence, and mortality in New York
City, Philadelphia, and Chicago during the first six months of the pandemic. Ecological, observational study at the zip code tabulation area (ZCTA) level from March to August 2020. We found spatial clusters of high and low positivity, incidence and mortality,
co-located with clusters of low and high social vulnerability. We also found evidence for the existence of spatial inequities in testing, positivity, incidence and mortality for the three cities. Specifically, neighborhoods with higher social vulnerability
had lower testing rates, higher positivity ratios, incidence rates and mortality rates. Inequities in testing and incidence changed over time in the three cities, and inequities in positivity stayed consistent over time. ZCTAs are imperfect and heterogeneous
geographical units of analysis. We rely on surveillance data, which may be incomplete. |
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Bilich, Tatjana, Nelde, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques Immunology | Immunologie |
This study shows the longitudinal analysis of SARS-CoV-2 immunity in convalescents up to six months post-infection.
They revealed decreasing and stable spike and nucleocapsid antibody responses, respectively. In contrast, T cell responses remained robust and even increased in frequency and intensity. Single epitope mapping of T cell diversity over time identified ORF-independent,
dominant T cell epitopes mediating long-term SARS-CoV-2 T cell responses and may be fundamental for vaccine design. |
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Bolaño-Ortiz, TR, Pascual-Flores, et al |
Atmosphere |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique
Surveillance |
This work studied the spread of COVID-19, the meteorological conditions and the air quality in a megacity from two
viewpoints: (1) the correlation between meteorological and air quality (PM10 and NO2) variables with infections and deaths due COVID-19, and (2) the improvement in air quality. Our findings showed a significant correlation of meteorological and air quality
variables with COVID-19 cases. The highest temperature correlation occurred before the confirmation day of new cases. PM10 presented the highest correlation within 13 to 15 days lag, while NO2 within 3 to 6 days lag. Also, reductions in PM10 and NO2 were observed.
This study shows that exposure to air pollution was significantly correlated with an increased risk of becoming infected and dying due to COVID-19. |
|
|
Incidence of thrombotic outcomes for patients hospitalized and discharged after COVID-19
infection |
Bourguignon, A, Beaulieu, et al |
Thrombosis research |
Clinical data| Données cliniques |
We have evaluated the rates of in-hospital thrombotic events as well as rates of thrombosis after discharge. We first
did a retrospective cohort study of every adult patient hospitalized with a confirmed COVID-19 infection at the Centre Hospitalier Universitaire de Montréal from March 2020 until June 27th 2020. COVID-19 cases received systematic low-dose thromboprophylaxis
although our ICU protocol allowed for intermediate-dose prophylaxis and full anti-coagulation in selected high-risk as of April 7th 2020 based on emerging literature on this subject. The dose increase was suggested for patients with BMI > 30, for ICU patients
and those with a personal history of VTE not currently on anticoagulation. Of the 454 patients hospitalized with COVID-19 infection, 285 were admitted exclusively on the ward and another 78 were admitted in the ICU at some point in their stay. A distinct group
of 91 patients were admitted to a COVID-19 rehabilitation ward from various institutions in the city. Thromboprophylaxis was administered to 91,2% of the ward population, 96,2% of the ICU population and 88% of the rehabilitation ward population. Failure to
receive prophylaxis was related to high bleeding risk in most cases or dying within a very short period. |
|
Bretschger, L, Grieg, et al |
International Economics and Economic Policy |
Epidemiology| Épidémiologie Surveillance |
This paper presents empirical results on coronavirus infection and fatality rates from cross-country regressions for
OECD economies and a sample of middle- and high-income countries. We find a significant positive impact of local air pollution on infection rates in the whole sample and on fatality rates for OECD countries. Obesity rates have a positive effect on cases and
deaths across the different estimation equations. The strategy of aiming to achieve herd immunity has a significant positive effect on infections as well as on death rates. The first affected countries have significantly higher mortality rates, revealing the
lack of experience and medical capacity to deal with the pandemic in an initial phase. |
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|
Bridge, J, Meng, et al |
IEEE journal of biomedical and health informatics |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study proposes new methods to traditional deep learning to overcome data dis-balancing challenges when developing
automatic diagnosis algorithms. A novel activation function based on the generalized extreme value (GEV) distribution from extreme value theory is proposed which improves performance over the traditional sigmoid activation function. Demonstrated the proposed
activation function on a publicly available dataset and externally validated on a dataset consisting of 1,909 healthy chest X-rays and 84 COVID-19 X-rays. The proposed method achieved an improved area under the receiver operating characteristic (DeLong's p-value
< 0.05) compared to the sigmoid activation. Also achieved improved sensitivity on a dataset of healthy and pneumonia vs. COVID-19 X-rays and a set of computerized tomography image. |
|
|
Briggs, D, Ellis, et al |
International Journal of Sociology and Social Policy |
Public Health response| Interventions de santé publique Economics | Économie |
The purpose of this paper is to consider the implications of both the Covid-19 pandemic and UK lockdown for the social,
political and economic future of the UK. The findings suggest that while the lockdown suspended daily routines and provoked participants to reflect upon their consumption habits and the possibility of an alternative future, many of the respondents remained
strongly attached to elements of pre-lockdown normality. Furthermore, the individual impetus for change was not matched by the structures and mechanisms holding up neoliberalism, as governments and commercial enterprises merely encouraged people to get back
to the shops to spend. |
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The Geography of Travel Behavior in the Early Phase of the Covid-19 Pandemic |
Brinkman, Jeffrey, Mangum, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
This study uses a panel of county-level location data derived from cellular devices in the U.S. to track travel behavior
and its relationship with COVID-19 cases in the early stages of the outbreak. And found that travel activity dropped significantly as case counts rose locally. People traveled less overall, and they specifically avoided areas with relatively larger outbreaks,
independent of government restrictions on mobility. The drop in activity limited exposure to out-of-county virus cases, which was important because such case exposure generated new cases inside a county. This suggests the outbreak would have spread faster
and to a greater degree had travel activity not dropped accordingly. |
|
Brüggemann, RAG, Spaetgens, et al |
Thrombosis research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study investigated how often pulmonary embolism (PE)was present in individuals with COVID-19 and respiratory
deterioration in different settings, and whether or not disease severity as measured by CT-severity score (CTSS) was related to the occurrence of PE. A total of 24 (24/60: 40% (95% CI: 28–54%)) patients were diagnosed with PE, of whom 6 were in the ED (6/23:
26% (95%CI: 10–46%)), 8 in the regular ward (8/24: 33% (95%CI: 16–55%)), and 10 in the ICU (10/13: 77% (95% |
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Burks, JD, Luther, et al |
World Neurosurgery |
Healthcare Response | Réponse des soins de santé |
This study examined how neurosurgical residents have been affected, and analyzed the operative experience in the months
leading up to and during the pandemic. The case totals for all levels of training were lower when restrictions were placed on elective surgeries. An average of 11 cases was logged in April 2020, a decrease from 26 cases in April 2019 (95% confidence interval,
8.7–22; P < 0.01). An average of 20 cases was logged in May 2020, a decrease from 25 cases in May 2019 (95% confidence interval, 1.2–8.8; P = 0.01). In April and May 2020, 299 (66%) and 148 (50%) fewer cases had been performed at our institution compared with
April and May 2109. |
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Caffo, O, Gasparro, et al |
European journal of cancer |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This multi-centre cohort study investigated the incidence and outcomes of SARS-CoV-2 infection in patients with metastatic
castration-resistant prostrate cancer (mCRPC). Thirty-four of the 1433 patients with mCRPC attending the participating centres (2.3%) developed SARS-CoV-2 infection, 22 (64.7%) of whom were hospitalised. Most of the patients were symptomatic, the most frequent
symptoms being fever (70.6%), dyspnoea (61.8%), cough (52.9%) and fatigue (38.2%). After a median follow-up of 21 days (interquartile range: 13–41), 13 patients had died (38.2%), 17 recovered (50.0%) and four (11.7%) were still infected. The number of treatments
previously administered for mCRPC had a significant impact on mortality (p = 0.004). |
|
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Campedelli, GM, Aziani, et al |
American Journal of Criminal Justice |
Public Health response| Interventions de santé publique |
This work investigates whether and how COVID-19 containment policies had an immediate impact on crime trends in Los
Angeles. In Los Angeles, overall crime has significantly decreased, as well as robbery, shoplifting, theft, and battery. No significant effect has been detected for vehicle theft, burglary, assault with a deadly weapon, intimate partner assault, and homicide. |
|
|
Cao, Z, Tang, et al |
J Med Internet Res |
Epidemiology| Épidémiologie |
This study objective was to systematically reveal factors and their contribution to the control of COVID-19 in China,
both at the national and city level. Many factors contributed to the outbreak outcome of COVID-19 in China. Travel-related population movement was the main driving factor with strong lag effect, and population movement from non-Wuhan regions is a non-ignorable
hidden variable. For the growth rate, more factors were involved, including the socioeconomic ones that contributed more than a quarter. |
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Automatic Pleural Line Extraction and COVID-19 Scoring From Lung Ultrasound Data |
Carrer, L, Donini, et al |
IEEE Trans Ultrason Ferroelectr Freq Control |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This paper proposes an automatic and unsupervised method for the detection and localization of the pleural line in
lung ultrasound (LUS) data based on the hidden Markov model and Viterbi Algorithm. The experiments performed on a variety of LUS data acquired in Italian hospitals with both linear and convex probes highlight the effectiveness of the proposed method. The
average overall accuracy in detecting the pleura is 84% and 94% for convex and linear probes, respectively. The accuracy of the support vector machine (SVM) classification in correctly evaluating the severity of COVID-19 related pleural line alterations is
about 88% and 94% for convex and linear probes, respectively. |
|
Chakraborti, S, Maiti, et al |
Science of the Total Environment |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study explores the functional capabilities of Machine Learning (ML) models in epidemiological research, especially
for COVID-19. And adopted two advanced ML models, viz. Random Forest (RF) and Gradient Boosted Machine (GBM), to perform the regression modelling and provide subsequent interpretation. Five successive steps were followed to carry out the analysis: (1) identification
of relevant key explanatory variables; (2) application of data dimensionality reduction for eliminating redundant information; (3) utilizing ML models for measuring relative influence (RI) of the explanatory variables; (4) evaluating interconnections between
and among the key explanatory variables and COVID-19 case and death counts; (5) time series analysis for examining the rate of incidences of COVID-19 cases and deaths. Among the explanatory variables considered in this study, air pollution, migration, economy,
and demographic factor were found to be the most significant controlling factors. |
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Topics, Trends, and Sentiments of Tweets About the COVID-19 Pandemic: Temporal Infoveillance Study |
Chandrasekaran, R, Mehta, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
This study examined key themes and topics of English-language COVID-19-related tweets posted by individuals and to
explore the trends and variations in how the COVID-19-related tweets, key topics, and associated sentiments changed over a period of time from before to after the disease was declared a pandemic. Of the 13,937,906 examined tweets, 2,858,316 (20.51%) were about
the impact of COVID-19 on the economy and markets, followed by spread and growth in cases (2,154,065, 15.45%), treatment and recovery (1,831,339, 13.14%), impact on the health care sector (1,588,499, 11.40%), and governments response (1,559,591, 11.19%). Average
compound sentiment scores were found to be negative throughout the examined time period for the topics of spread and growth of cases, symptoms, racism, source of the outbreak, and political impact of COVID-19. In contrast, saw a reversal of sentiments from
negative to positive for prevention, impact on the economy and markets, government response, impact on the health care industry, and treatment and recovery. |
|
Chapagain, K, Rauniyar, et al |
Journal of the Nepal Medical Association |
Public Health response| Interventions de santé publique |
This study was conducted to find out the extent of information general people of Eastern Nepal have regarding COVID-19
and their attitude and practice towards preventing its spread. Among 1069 respondents, the correct answer on the COVID-19 related knowledge questionnaire was 958 (89.61%), 487 (93.11%) were health professionals, and 471 (86.26%) non-health professionals. Preventive
measures were strictly followed by 1044 (97.66%) participants. A wrong perception about the disease was present in 390 (36.48%). Health ministry website 356 (33.30%) followed by news media 309 (29%) was the major source of information among the people. |
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Social connections with COVID-19-affected areas increase compliance with mobility restrictions |
Charoenwong, B, Kwan, et al |
Sci Adv |
Public Health response| Interventions de santé publique |
This research studied the role of social connections in U.S. households' compliance with mobility restrictions imposed
in response to the COVID-19 pandemic, using aggregated and anonymized Facebook data on social connections and mobile phone data for measuring social distancing at the county level. Results are not driven by traveler risk, as areas at higher risk from COVID-19
generally comply with restrictions more and are less affected by social connections. Social connections with counties with a less educated population, higher Trump vote share, and higher fraction of climate change deniers are associated with increased effects
of mobility restrictions. |
|
Chen, S, Chen, et al |
Engineering |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study explored the impact of the timing and duration of outbreak-control holidays on the coronavirus disease 2019
(COVID-19) epidemic spread during the early stage in China. Results show that the outbreak-control holiday in China likely stalled the spread of COVID-19 for several days. The base case outbreak-control holiday (21 d for Hubei province and 10 days for all
other provinces) delayed the time to reach 100 000 confirmed infections by 7.54 d. A longer outbreak-control holiday would have had stronger effects. A nationwide outbreak-control holiday of 21 d would have delayed the time to 100 000 confirmed infections
by nearly 10 d. |
|
|
Chen, Shi, Li, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This research developed a travel-network-based susceptible-exposed-infectious-removed (SEIR) mathematical compartmental
model system that characterizes infections by state and incorporates inflows and outflows of interstate travelers. Modeling reveals that curbing interstate travel when the disease is already widespread will make little difference. Meanwhile, increased testing
capacity (facilitating early identification of infected people and quick isolation) and strict social-distancing and self-quarantine rules are most effective in abating the outbreak. The modeling has also produced state-specific information. For example, for
New York and Michigan, isolation of persons exposed to the virus needs to be imposed within 2 days to prevent a broad outbreak, whereas for other states this period can be 3.6 days. |
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Association between Risk of Venous Thromboembolism and Mortality in Patients with COVID-19 |
Chen, Shujing, Wang, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study investigated the association between risk of venous thromboembolism (VTE) with 30-day mortality in COVID-19
patients. Thirty-day mortality increased progressively from 2% in patients at low risk of VTE to 63% in those at high risk of VTE defined by PPS ≥ 4. Similar findings were also observed for risk of VTE defined by IMPROVE score ³ 2 and Caprini score ³ 5. Progressive
increases in VTE risk also were associated with higher SOFA score. Findings showed that the presence of high risk of VTE was independently associated with 30-day mortality regardless of adjusted gender, smoking status and some comorbidities with hazard ratios
of 29.19 (95% CI 15.76 - 54.05), 37.37 (95% CI 18.43 - 75.78), 20.60 (95% CI 11.41 - 37.19) for PPS, IMPROVE RAM and Caprini RAM, respectively (P < 0.001 for all comparisons). Predictive accuracy of PPS, IMPROVE RAM or Caprini RAM as the risk of 30-day mortality
was markedly well. |
|
Reducing False Negatives in COVID-19 Testing by Using Microneedle-Based Oropharyngeal Swabs |
Chen, W, Cai, et al |
Matter |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This research engineered regular swabs by using a microneedle (MN) patch to significantly improve the quality and quantity
of virus collection. The combination of MNs with different crosslinking levels endows the patches with dual capability of mucus penetration and virus extraction. Moreover, the antibody (Ab) against viral spike protein was integrated into the patch, conferring
MNs with an active virus capture potential. The authors believe that the designed MN/Ab swabs could serve as a promising tool to improve current sampling efficiency with fewer false negatives, contributing to the containment of the COVID-19 pandemic. |
|
Tocilizumab use in patients with moderate to severe COVID-19: A retrospective cohort study |
Chilimuri, S, Sun, et al |
J Clin Pharm Ther |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
This single-centre retrospective cohort study examined the association between tocilizumab use and intubation or death
at a community hospital in New York City. The study involved 1225 hospitalized patients with SARS-CoV-2 infection, the probability to respiratory failure, which was measured as intubation or death, was less frequent in patients who received tocilizumab. |
|
Antiviral Peptides as Promising Therapeutics against SARS-CoV-2 |
Chowdhury, SM, Talukder, et al |
J Phys Chem B |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study examined peptides known to inhibit SARS-CoV-1. These were computationally screened against the receptor-binding
domain (RBD) of the spike protein of SARS-CoV-2. Based on the binding affinity and interaction, 15 peptides were selected, which showed higher affinity compared to the α-helix of the human ACE2 receptor. Molecular dynamics simulation demonstrated that two
peptides, S2P25 and S2P26, were the most promising candidates, which could potentially block the entry of SARS-CoV-2. Tyr489 and Tyr505 residues present in the "finger-like" projections of the RBD were found to be critical for peptide interaction. Hydrogen
bonding and hydrophobic interactions played important roles in prompting peptide-protein binding and interaction. Structure-activity relationship indicated that peptides containing aromatic (Tyr and Phe), nonpolar (Pro, Gly, Leu, and Ala), and polar (Asn,
Gln, and Cys) residues were the most significant contributors. |
|
Impact of health risk perception on avoidance of international travel in the wake of a pandemic |
Chua, BL, Al-Ansi, et al |
Current Issues in Tourism |
Public Health response| Interventions de santé publique |
This study examined the role of negative affect, perceived health risk, perceived uncertainty, and mental wellbeing
in forming travel attitudes and temporal avoidance behaviour to global destinations seriously-hit by the COVID-19 pandemic from a U.S. tourist perspective. The cross-sectional online survey showed that negative affect as a result of COVID-19 significantly
influenced perceived health risk, which in turn induced mental wellbeing and perceived uncertainty. While mental wellbeing significantly predicted attitudes towards international travel and temporal avoidance behaviour, perceived uncertainty significantly
predicted short-term avoidance behaviour. |
|
Çinier, G, Hayıroğlu, et al |
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir |
Healthcare Response | Réponse des soins de santé |
This study investigated the access to primary percutaneous coronary intervention (PPCI) for patients diagnosed with
ST-segment myocardial infarction (STEMI) during the pandemic. There was a significant reduction in the number of STEMI cases during the COVID-19 crisis period. Furthermore, these patients had a prolonged ischemic time; they were more likely to have a longer
pain-to-balloon (Odds ratio OR]: 2.0, 95% confidence interval CI]: 1.1-10.2) and door-to-balloon time (OR: 5.4, 95%CI: 3.1-22.8). Patients diagnosed with STEMI during the pandemic experienced a significant delay between the onset of symptoms and PPCI. |
|
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Cobre, AF, Böger, et al |
Journal of Public Health (Germany) |
Epidemiology| Épidémiologie |
This study investigated the risk factors associated with death from COVID-19 in four countries: The USA, Italy, Spain,
and Germany. Among the evaluated countries, Italy presented greater need for ICU beds/day (≤ 98; OR = 2315.122; CI 95% 334.767–16,503.502]; p < 0.001) and daily ventilation devices (≤ 118; OR = 1784.168; CI 95% 250.217–12,721.995]; p < 0.001). It is expected
that both Italy and Spain have a higher ICU admission rate due to COVID-19 (n = 14/day). Spain will need more beds/day (≤ 357; OR = 146.838; CI 95% 113.242–190.402]; p < 0.001) and probably will have a higher number of daily hospital admissions (n = 48/day).
All the above-mentioned factors have an important impact on patients’ mortality due to COVID-19 in all four countries. |
|
|
Coll, E, Fernández-Ruiz, et al |
Am J Transplant |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study reports the Spanish experience with solid organ transplant (SOT) and hematopoietic stem cell transplant
(HSCT) recipients diagnosed with coronavirus disease 2019 (COVID-19) until 13 July 2020. The incidence of COVID-19 in SOT recipients was two-fold higher compared to the Spanish general population. The median interval from transplantation was 59 months (IQR:
18-131). Infection was hospital-acquired in 13% of cases. No donor-derived COVID-19 was suspected. Most patients (89%) were admitted to the hospital. Adjustment of immunosuppression was performed in 85% of patients. At the time of analysis, complete follow-up
was available from 652 patients. Acute respiratory distress syndrome occurred in 35% of patients. Ultimately, 174 (27%) patients died. In univariate analysis, risk factors for death were lung transplantation (odds ratio OR]: 2.5; 95%CI: 1.4-4.6), age >60 years
(OR: 3.7; 95%CI: 2.5-5.5), and hospital-acquired COVID-19 (OR: 3.0; 95%CI: 1.9-4.9). |
|
|
Colombi, D, Petrini, et al |
European Journal of Radiology |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study compared the diagnostic performance of admission chest computed tomography (CT) and lung ultrasound (LUS)
for the diagnosis of COVID-19. The study included 486 patients (males 61 %; median age, 70 years): 247 patients in high prevalence group (HP)(COVID-19 prevalence 94 %) and 239 patients in moderate prevalence group (MP) (COVID-19 prevalence 45 %). In HP and
MP respectively, sensitivity, specificity, PPV, and NPV were 90–95 %, 43–69 %, 96−72 %, 20–95 % for CT and 94−93 %, 7–31 %, 94−52 %, 7–83 % for LUS. CT demonstrated better performance than LUS in diagnosis of COVID-19, both in HP (AUC 0.75 vs 0.51; P < 0.001)
and MP (AUC 0.85 vs 0.62; P < 0.001). |
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Constant, A, Conserve, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
The study assessed changes in lifestyles in the general population in response to coronavirus disease 2019 (COVID-19)
lockdown and the influence of COVID-19 perceptions, as assessed by the Extended Parallel Process Model (EPPM), on these changes. More than 8 in 10 respondents reported unhealthy changes in lifestyle since the lockdown, mostly in relation to physical activity.
The unhealthy changes were positively associated with male sex , living urban density, having a garden, financial difficulties because of COVID-19 , and lack of fear control and negatively with cognitive avoidance. Less than 4 in 10 respondents reported healthy
changes over the same period, mostly in relation to better eating habits. They were positively associated with living with more than two persons, having a terrace, and perceived efficacy and negatively with being aged 40 or higher. Alcohol consumption overall
declined in regular drinkers, while a slight increase in tobacco use was observed in regular smokers. |
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The use of facemasks during the COVID-19 pandemic by the Brazilian population |
Cotrin, P, Bahls, et al |
Journal of Multidisciplinary Healthcare |
Public Health response| Interventions de santé publique |
This study evaluated the use of facemasks by the Brazilian population during the COVID19 pandemic. A total of 1277
answered the questionnaire, and most participants were female (81.8%). Almost all the participants (99.1%) reported wearing facemasks, and 34.2% are wearing just because it is mandatory; 65.8% would continue to wear masks even if it was not mandatory. Most
subjects (50.4%) believe that masks’ use effectively prevents infection by the novel coronavirus. Reusable fabric facemasks are the most used by the participants (49.5%). Almost all subjects were wearing masks to go to crowded and public places. Most respondents
(67.3%) are bothered with the use of facemasks, and the most cited reason for the discomfort was feeling trapped or suffocated (58.9%). |
|
Early evidence of the impacts of COVID-19 on minority unemployment |
Couch, KA, Fairlie, et al |
Journal of Public Economics |
Economics | Économie |
This paper provides early evidence of the impacts of the COVID-19 pandemic on minority unemployment in the United States.
In the first month following March adoptions of social distancing measures by states, unemployment rose to 14.5% but a much higher 24.4% when we correct for potential data misclassification noted by the BLS. Using the official definition, unemployment in April
2020 among African-Americans rose by less than what would have been anticipated (to 16.6%) based on previous recessions, and the long-term ordering of unemployment across racial/ethnic groups was altered with Latinx unemployment (18.2%) rising for the first
time to the highest among major groups. Difference-in-difference estimates confirm that the initial gap in unemployment between whites and blacks in April was not different than in periods prior to the pandemic; however, the racial gap expanded as unemployment
for whites declined in the next two months but was largely stagnant for blacks. |
|
A preliminary impact assessment of social distancing on food systems and greenhouse gas emissions |
Dada, O, Ogunyiola, et al |
Journal of Human Behavior in the Social Environment |
Public Health response| Interventions de santé publique Economics | Économie |
This study explored the implications of policies such as social distance, lockdown, and curfews implemented by various
national governments on food systems and greenhouse emissions. Using data from International Food and Policy Research, the authors identified limited transportation, lockdown, ban of public gathering, and closure of schools and religious institutions as prominent
measures in mitigating the effects of COVID-19 by many countries. And observed that these policies have unintended consequences for food systems and greenhouse gas emissions, mainly CO2. Implementing these policies show that CO2 emission reduced, and existing
challenges of food systems are further aggravated with these policies. |
|
Dakay, K, Kaur, et al |
Journal of Stroke and Cerebrovascular Diseases |
Clinical data| Données cliniques |
This report presents the case of a very rapid neurologic and radiographic decline of a patient with an acute ischemic
stroke who developed rapid fulminant cerebral edema leading to herniation in the setting of hypercarbic respiratory failure attributed to SARS-CoV-2 infection. |
|
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33053015; Quantitative analysis in COVID-19: report of an initial experience |
Dalprá, FAR, Fonseca, et al |
Einstein (Sao Paulo, Brazil) |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Healthcare
Response | Réponse des soins de santé |
The present case demonstrates the use of the 3DSlicer tool for the quantification of pulmonary tomographic changes,
applied in the clinical monitoring of the patient, enabling an objective estimation of the involvement percentage and the progression rate of the disease. The 3DSlicer software is a free tool available online |
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Love Thy Neighbor? Perceived Community Abidance and Private Compliance to COVID-19 Norms in India |
Das, Upasak, Sarkhel, et al |
arXiv |
Public Health response| Interventions de santé publique |
This study assessed if changes in perceived community compliance can predict changes in individual compliance behavior
while controlling for the potential confounders. Observed statistically significant and positive relationship between the two, even after accounting for omitted variable bias, plausibly allowing us to view the results from a plausible causal lens. Further,
with subsequent lockdowns had a detrimental effect on individual compliance though the gains from higher perceived community compliance seems to offset this loss. Also found that sensitization through community can be particularly effective for people with
pre-existing co-morbidities. |
|
Datta, NR, Datta, et al |
Advances in Radiation Oncology |
Healthcare Response | Réponse des soins de santé |
This study examined the alternative strategies needed to improve the existing radiation therapy (RT) accessibility
without significant cost escalation. In 46 countries, 4617 TRT units are available. The mean percent of RT accessibility is 62.4% in 43 countries (TRT units = 4491) where the information on cancer incidence was also available, and these would need an additional
6474 TRT units for achieving 100% RT accessibility. By adopting HFRT alone, increasing the working hours by 25% alone, 25% with HFRT, 50% alone, and 50% with HFRT, the percent of RT access could improve to 74.9%, 78%, 90.5%, 93.7%, and 106.1%, respectively.
Correspondingly, the need for additional TRT units would progressively decrease to 4646, 4284, 3073, 2820, and 1958 units. |
|
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Davis, NR, Doughty, et al |
BMJ Simulation and Technology Enhanced Learning |
Healthcare Response | Réponse des soins de santé |
This study performed a simulation exercise by using Simulation-based clinical systems testing (SbCST) simulation to
test preoccupancy spaces and identify new processes. Texas Children's Hospital (TCH) redeployed their mobile paediatric emergency response teams to alternative care sites (ACS) during surge event. Within a 2-week period, participants from 20 different departments
identified 109 latent safety threats (LSTs) across the four activities, with 71 identified as being very high or high priority items. Very high and high priority threats were prioritised in mitigation efforts by hospital leadership. |
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Trend of Allergic Rhinitis Post COVID-19 Pandemic: A Retrospective Observational Study |
Dayal, AK, Sinha, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Public Health response| Interventions de santé publique |
To study, compare and analyse the trend of allergic rhinitis incidence post COVID-19 pandemic in a tertiary care hospital
in Patna Bihar. This is a retrospective observational study done at Patna medical college from January to June 2020. The number of patients with signs and symptoms of allergic rhinitis post pandemic (March–July2020) were compared to preceding three months
(Jan 2020–March2020). Chi square test was employed to know and infer whether the change in trend of incidence is statistically significant. There is decrease in trend of allergic rhinitis in our study at our centre. P <.01. Decrease in pollution due to lockdown
and increased use of mask and increase indoor activities may be the reason for decreasing trend of allergic rhinitis. |
|
Dayer, Mohammad Reza |
arXiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In the present work, the inhibitory properties of different analgesic drugs on these targets are studied to assess
their ability for clinical application from different points of view. Our docking results indicated that naproxen, methadone, and amitriptyline considering their higher binding energy, lower energy variance, and higher hydrophobicity, seem to express more
inhibitory effects on Janus kinase enzymes than thats for approved inhibitors i.e. baricitinib and ruxolitinib. Accordingly, we suggest our wide list of candidate drugs including indomethacin, etodolac, buprenorphine, rofecoxib, duloxetine, valdecoxib, naproxen,
methadone, and amitriptilin for clinical assessments for their usefulness in COVID-19 treatment, especially taking into account that up to now, there is no approved cure for this disease. |
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Prevalence and prognostic value of cardiac troponin in elderly patients hospitalized
for COVID-19 |
De Marzo, Vincenzo, Di Biagio, et al |
Research Square prepub |
Clinical data| Données cliniques |
From a registry of consecutive patients with COVID-19 admitted to a hub hospital in Italy from 25/02/2020 to 03/07/2020,
we selected those ≥60 year-old and with cTnI measured within 3 days from the molecular diagnosis of SARS-CoV-2 infection. Of 343 included patients (median age 75.0 (68.0-83.0) years, 34.7% men), 88 (25.7%) had cTnI above the upper-reference limit (0.046 µg/L).
Patients with increased cTnI had more comorbidities, greater impaired respiratory exchange and higher inflammatory markers on admission than those with normal cTnI. Furthermore, they died more (73.9% vs. 37.3%, p<0.001) over 15 (6-25) days of hospitalization.
The association of elevated cTnI with mortality was confirmed by the adjusted Cox regression model (HR: 1.61, 95% CI: 1.06-2.52, p=0.039) and was linear until 0.3 µg/L, with a subsequent plateau. Of 191 (55.7%) patients with a second cTnI measurement, 49 (25.7%)
had an increasing trend, which was not associated with mortality (univariate HR 1.39, 95%CI 0.87-2.22, p=0.265). |
|
Delorme, Cécile, Houot, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to describe the spectrum of neurological and psychiatric complications in patients with Covid-19 seen
in a multidisciplinary center over six months. 245 patients were included in the analysis. One-hundred fourteen patients (47%) were admitted to the intensive care unit (ICU) and 10 (4%) died. The most frequently reported neuropsychiatric symptoms were motor
deficit (41%), cognitive disturbance (35%), impaired consciousness (26%), psychiatric disturbance (24%), headache (20%) and behavioral disturbance (18%). The most frequent syndromes diagnosed were encephalopathy (43%), critical illness polyneuropathy and myopathy
(26%), isolated psychiatric disturbance (18%), and cerebrovascular disorders (16%). No patients showed evidence of SARS-CoV-2 in their CSF. Encephalopathy was associated with greater age and higher risk of death. Critical illness neuromyopathy was associated
with an extended stay in the ICU. |
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Flattening the COVID-19 Curve: The “Greek” case in the Global Pandemic |
Demertzis, Konstantinos, Magafas, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Focusing on the peculiarities of the disease spreading in Greece, both in epidemiological and in implementation terms,
this paper applies an exploratory analysis of COVID-19 temporal spread in Greece and proposes a methodological approach for the modelling and prediction of the disease based on the Regression Splines algorithm and the change rate of the total infections. Also,
it proposes a hybrid spline regression and complex network model of social distance measures evaluating and interpreting the spread of the disease. |
|
Demetriou, Loucia, Drakontaides, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
Our study aims to explore the effects of psychological resilience, hope, and adaptability when people experience real
or perceived possible danger. We administered the instruments to 205 Greek and Cypriot men and women in age groups of 18 years or older. Our findings showed that high scores in hope could predict higher levels of psychological resilience and the ability to
adapt in the face of adversity. We have also found a significant positive relationship between age and level of education with psychological resiliency. Older participants and participants with higher levels of education showed higher levels of psychological
resiliency and adaptation in comparison with the younger and less educated subjects. At the same time, findings indicated that although people adapted and complied with extreme social isolation measures, neither did they actually trust the relevant state policies,
nor did they rely on mass media for information regarding the pandemic. |
|
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32996993; Neuropsychiatric changes during the COVID-19 pandemic in multiple sclerosis patients |
Demir, CF, Bilek, et al |
Arquivos de Neuro-Psiquiatria |
Public Health response| Interventions de santé publique |
The aim of this cross-sectional study was to investigate the neuropsychiatric effects of the COVID-19 pandemic in MS
patients and to analyze the risk factors contributing to psychological stress. Fifty patients were included in the study. BDI scores, PSQI and FSI measurements, cognitive and social subscale scores and total FIS score, MSQOL-54 measurements, physical and mental
subscale scores, and total MSQOL-54 score at PSO were significantly different than those at ESO. The body mass index values of the patients increased significantly at PSO compared to those measured at ESO. The results provide a basis for the development of
psychological interventions that could minimize the prevalence of sleep disorders and depression and could improve patients’ quality of life during the outbreak. |
|
Deng, X, Shao, et al |
CMES - Computer Modeling in Engineering and Sciences |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
One of the most effective and critical steps in the fight against COVID-19, is to examine the patient’s lungs based
on the Chest X-ray and CT generated by radiation imaging. In this paper, five keras-related deep learning models: ResNet50, InceptionResNetV2, Xception, transfer learning and pre-trained VGGNet16 is applied to formulate an classification–detection approaches
of COVID-19. Two benchmark methods SVM (Support Vector Machine), CNN (Conventional Neural Networks) are provided to compare with the classification–detection approaches based on the performance indicators, i.e., precision, recall, F1 scores, confusion matrix,
classification accuracy and three types of AUC (Area Under Curve). The highest classification accuracy derived by classification–detection based on 5857 Chest X-rays and 767 Chest CTs are respectively 84% and 75%, which shows that the keras-related deep learning
approaches facilitate accurate and effective COVID-19-assisted detection. |
|
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Dhiman, S, Sahu, et al |
Research in developmental disabilities |
Healthcare Response | Réponse des soins de santé |
The objectives of this study were to describe the mental health status and the change in perceived strain among caregivers
during the COVID-19 outbreak. The prevalence of depression, anxiety and stress symptoms were found to be 62.5 %, 20.5 % and 36.4 % respectively. A significant difference in caregiver strain (p < 0.001, effect size = 0.93) was observed during the outbreak compared
to levels pre-outbreak (pre-outbreak strain was measured retrospectively). Caregivers not using tele-rehabilitation along with a perception of it being a poor medium for rehabilitation were at greater risks for poor mental health whereas a negative perception
on homecare therapy were strongly associated with higher psychological symptoms and strain. |
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Psychological Impact of Coronavirus Disease 2019 Among Italians During the First Week of Lockdown |
Di Giuseppe, M, Zilcha-Mano, et al |
Frontiers in Psychiatry |
Public Health response| Interventions de santé publique |
In this cross-sectional study, 5,683 Italians responded to an online survey assessing socio-demographics, overall psychological
distress, post-traumatic symptoms, and defense mechanisms. Results showed that younger age and female gender were associated with increased psychological distress. Having positive cases nearby, more days on lockdown, and having to relocate were also associated
with greater distress. The psychological impact of COVID-19 among Italians during the early weeks of government lockdown has been significant. |
|
Di Monte, C, Monaco, et al |
Frontiers in Psychology |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to explore the relationships between dimensions of burnout and various psychological features
among Italian GPs during the COVID-19 emergency. Cluster analysis highlighted four distinct burnout risk profiles: Low Burnout, Medium Risk, High Risk, and High Burnout. The High Burnout group showed both lower Resilience and lower CISS Task-oriented coping
strategy than the Medium Risk group and higher IU Prospective than the Low Burnout group. Results of a linear regression analysis confirmed that CISS Emotion-oriented style positively predicted MBI Emotional Exhaustion, CISS Task-oriented and Emotion-oriented
emerged as significant predictors (negatively and positively, respectively) of MBI Depersonalization, and Resilience positively predicted MBI Personal Accomplishment. In conclusion, the results showed that the COVID-19 emergency had a significant impact on
GPs’ work management. |
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Hospital staff well-being during the first wave of COVID-19: Staff perspectives |
Digby, R, Winton-Brown, et al |
Int J Ment Health Nurs |
Healthcare Response | Réponse des soins de santé |
The purpose of this research is to determine the impact of working during the early stage of the COVID-19 pandemic
on the well-being of staff at one 600-bed acute hospital in metropolitan Melbourne, Australia. Respondents reported anxiety, fear and uncertainty related to the pandemic, from the perspectives of work, home, family and community. They reported feeling confused
by inconsistent messages received from government, hospital executive, managers and media. Seven themes were identified: (i) worrying about patient care, (ii) changed working conditions, (iii) working in the changed hospital environment, (iv) impact of the
pandemic, (v) personal isolation and uncertainty, (vi) leadership and management and (vii) additional support needed for staff. Despite the pandemic being comparatively well-controlled in Australia, all disciplines reported a high degree of anticipatory anxiety. |
|
Duan, J, Liang, et al |
Therapeutic Advances in Respiratory Disease |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Healthcare
Response | Réponse des soins de santé |
We aimed to develop a screening score to help the physicians to allocate the suspected patients at fever clinics, and,
further, to use this screening score to identify confirmed or probable cases in isolation wards. We enrolled 76 and 40 patients for internal and external validation, respectively. In the internal validation cohort, the area under the curve of receiver operating
characteristics (AUC) was 0.96 95% CI: 0.89–0.99] for the diagnosis of moderate to high probability of cases among all the suspected patients. Using 60 as cut-off value, the sensitivity and specificity were 88% and 93%, respectively. In the isolation ward,
the AUC was 0.94 (95% CI: 0.83–0.99) for the diagnosis of confirmed and probable cases. Using 90 as cut-off value, the sensitivity and specificity were 78% and 100%, respectively. These results were confirmed in the validation cohort. |
|
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The effect of COVID-19 on critical care research: A prospective
longitudinal multinational survey |
Duffett, Mark, Cook, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
This study aimed to determine the effect of the first wave of the COVID-19 pandemic on critical care clinical research.
126 centers (56% pediatric) from 23 countries participated. 95 (75%) of centers suspended recruitment in at least some studies and 37 (29%) suspended recruitment in all studies on at least one month. The proportion of centers reporting recruitment in all studies
increased over time (OR per month 1.3, 95% CI 1.1 to 1.5, p = 0.007), controlling for hospitalized patients with COVID-19 and type of ICU (pediatric vs. other). The five factors most frequently identified as having a large or very large effect on clinical
research were: local prioritization of COVID-19 specific research (68, 54%), infection control policies limiting access to patients with COVID-19 (61, 49%), infection control policies limiting access to the ICU (52, 41.6%), increased workload of clinical staff
(38, 30%), and safety concerns of research staff (36, 29%). |
|
Dzien, C, Halder, et al |
Wien Klin Wochenschr |
Public health interventions*| Interventions de santé publique |
Body temperature control is a frequently used screening test for infectious diseases, such as Covid-19 (Sars-CoV-2).
We used this procedure to test the body temperature of staff members in a hospital in Tyrol (Austria), where the Covid-19 disease occurred in March 2020. Complete data of body temperature were available for 46 female and 46 male study participants. Our results
indicate that forehead infrared temperature control is not an appropriate tool to screen for infectious disease directly at the entrance of a building, at least during early spring season with cold outdoor temperatures. |
|
|
Eannucci, EF, Hazel, et al |
HSS Journal |
Public Health response| Interventions de santé publique |
We sought to compare patient satisfaction with in-person and telehealth PT and to determine the factors—such as age,
gender, or insurance payer—that contributed to patient satisfaction scores. We included completed surveys from 1147 patients in the analysis. The question of satisfaction was answered by 1074 patients. No statistical difference in satisfaction was seen in
age or gender groups. Satisfaction differed by insurance type, but when analysis excluded patients with international insurance, there was no difference between groups. In-person PT patients reported higher satisfaction in achieving treatment goals, as rated
on a 1-to-5 scale (4.7 ± 0.6), than telehealth PT patients (4.6 ± 0.6), although it is unclear if this result is clinically meaningful. There was no significant difference in the remaining follow-up questions. |
|
|
Eken, S |
Soft Computing |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper, real-time data are filtered and forwarded to the right processing node by using the proposed topic-based
hierarchical publish/subscribe messaging middleware in the distributed scalable network of collaborating computation nodes instead of classical approaches of centralized computation. This enables processing streaming medical data in near real time and makes
a warning system possible. End users have the capability of filtering/searching. The returned search results can be images (COVID-19 or non-COVID-19) and their meta-data are gender and age. Here, COVID-19 is detected using a novel capsule network-based model
from chest X-ray images. This middleware allows for a smaller search space as well as shorter times for obtaining search results. |
|
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Spatial autocorrelation and the dynamics of the mean center of
COVID-19 infections in Lebanon |
El Deeb, Omar |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper we study the spatial spread of the COVID-19 infection in Lebanon. We inspect the spreading of the daily
new infections across the 26 administrative districts of the country, and implement Moran's I statistics in order to analyze the tempo-spatial clustering of the infection in relation to various variables parameterized by adjacency, proximity, population, population
density, poverty rate and poverty density, and we find out that except for the poverty rate, the spread of the infection is clustered and associated to those parameters with varying magnitude for the time span between July (geographic adjacency and proximity)
or August (population, population density and poverty density) through October. We also determine the temporal dynamics of geographic location of the mean center of new and cumulative infections since late March. |
|
El-Gabalawy, Osama, Kim, et al |
medRxiv |
Public Health response| Interventions de santé publique |
To better understand how medical institutions have engaged with the social media discourse on BLM and COVID-19, we
examined psychiatry residency programs' tweets in response to George Floyd's murder and during the first 6 months of the COVID-19 pandemic in the U.S. Only 14% of the 249 evaluated psychiatry residency programs had Twitter accounts (we included programs with
their own account or their affiliated psychiatry department account) indicating a substantial absence on social media. Of those programs, 78% tweeted at least once about COVID-19 (1,153 tweets) and 56% tweeted at least once about the BLM movement (117 tweets).
The top three purposes of tweets were sharing media, posting about an event, and sharing a resource. |
|
|
Elgyoum, AMA, Zidan, et al |
Archives of the Balkan Medical Union |
Healthcare Response | Réponse des soins de santé |
This study aimed to evaluate the knowledge and practice of standard measures of IPCs among the staff of the radiology
departments in Sudan. A total of 68.3% of the study group knew the guidelines established by WHO to deal with COVID-19 patients or suspected cases. 65% of the respondents had previous training in hand hygiene and about 75% of them had sufficient knowledge
in hand hygiene, observed during their routine clinical practices. 69.2% of respondents used portable imaging equipment to limit the transportation of COVID-19 patients and 69.2% were aware that the patients were wearing a surgical mask when entering and leaving
the radiology department. |
|
|
COVID-19 Related Mortality During Management of a Hepatic Abscess |
Elliott, R, Ohene Baah, et al |
Journal of Radiology Nursing |
Clinical data| Données cliniques |
This article uses a patient case to highlight the importance of infection control during the height of the SARS-CoV-2
surge at a Level I affiliated community hospital in Western New York. |
|
Elzupir, AO |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study investigates the inhibitory effect of SARS-CoV-2 3-chymotrypsin-like protease (3CL(pro)) using caffeine
and caffeine-containing pharmaceuticals (3CPs) based on molecular dynamics simulations and free energy calculations by means of molecular mechanics-Poisson-Boltzmann surface area (MMPBSA) and molecular mechanics-generalized-Born surface area (MMGBSA). Of these
3CPs, seven drugs approved by the US-Food and Drug Administration have shown a good binding affinity to the catalytic residues of 3CL(pro) of His(41) and Cys(145): caffeine, theophylline, dyphylline, pentoxifylline, linagliptin, bromotheophylline and istradefylline.
Their binding affinity score ranged from -4.9 to -8.6 kcal/mol. The molecular dynamic simulation in an aqueous solution of docked complexes demonstrated that the 3CPs conformations bound to the active sites of 3CL(pro) during 200 ns molecular dynamics simulations.
The free energy of binding also confirms the stability of the 3CPs-3CL(pro) complexes. |
|
|
Eren, F, Demir, et al |
Turk Noroloji Dergisi |
Clinical data| Données cliniques |
This case report describes a 89-year-old female patient was admitted to the emergency department with the symptom of
impaired consciousness for 3 days. The COVID-19 test result was positive. |
|
|
Errecalde, Jorge, Lifschitz, et al |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
The safety and pharmacokinetic performance of a new Nasal IVM spray (NIVM) spray formulation in a piglet model were
assessed. Crossbred piglets (10/12 kg) were treated with either one or two (12 h apart) doses of N IVM spray (2 mg, 1 puff/nostril) or orally (0.2 mg/kg). The overall safety of NIVM-spray was assessed (clinical, haematological, serum biochemical determinations),
and histopathology evaluation of the application site tissues performed. Significant increases in IVM concentration profiles in both NPtissue and lungs were observed after the 2 dose nasal administrations. The nasal/oral IVM concentration ratios in NP and
lung tissues (at 6 h postdose) markedely increased by repeating the spray application. The fast attainment of high and persistent IVM concentrations in NP tissue is the main advantage of the nasal over the oral route. |
|
|
Escamilla-Fajardo, P, Núñez-Pomar, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
The aim of this study is to determine the impact of the crisis derived from COVID-19 on sports entrepreneurship and
whether there are differences in the prediction of entrepreneurship on service quality in non-profit sports clubs. The results obtained show that risk-taking and innovation are significantly higher after the appearance of COVID-19, while proactivity has not
undergone significant changes. Finally, the relationship between sports entrepreneurship and service quality is positive and significant in both stages but stronger before the crisis. |
|
|
Faasse, K, Newby, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
The aim of the current study was to examine the role of these factors in predicting recommended health-protective behaviors
early in the pandemic. Results revealed that two-thirds of respondents were at least moderately worried about a widespread COVID-19 outbreak. Worry about the outbreak and closely following media coverage were consistent predictors of greater engagement with
health-protective behaviors and higher vaccination intentions. Uncertainty and misconceptions about COVID-19 were common, including uncertainty about whether people are likely to have natural or existing immunity to the virus. There was also uncertainty around
whether specific home remedies (e.g., vitamins and saline rinses) would offer protection and whether the virus was human-made and deliberately released. |
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Fabiani, L, Saroglia, et al |
Biosensors and Bioelectronics |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Herein, we developed an electrochemical immunoassay for rapid and smart detection of SARS-CoV-2 coronavirus in saliva.
The analytical features of the electrochemical immunoassay were evaluated using the standard solution of S and N protein in buffer solution and untreated saliva with a detection limit equal to 19 ng/mL and 8 ng/mL in untreated saliva, respectively for S and
N protein. Its effectiveness was assessed using cultured virus in biosafety level 3 and in saliva clinical samples comparing the data using the nasopharyngeal swab specimens tested with Real-Time PCR. The agreement of the data, the low detection limit achieved,
the rapid analysis (30 min), the miniaturization, and portability of the instrument combined with the easiness to use and no-invasive sampling, confer to this analytical tool high potentiality for market entry as the first highly sensitive electrochemical
immunoassay for SARS-CoV-2 detection in untreated saliva. |
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Fan, BE, Ng, et al |
J Thromb Thrombolysis |
Clinical data| Données cliniques |
Overlapping syndromes of COVID-19 associated coagulopathy with consumptive coagulopathy and microangiopathy can be
seen in critically ill patients as well. Blood was collected from 12 Intensive Care Unit (ICU) patients with severe COVID-19 who were on either mechanical ventilation or on high flow oxygen with a PaO2/FiO2 ratio of <300 mmHg. A lupus anticoagulant was present
in 50% of patients. Our laboratory findings further support the view that severe SARS-CoV-2 infection is associated with a state of hypercoagulability. |
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Fang, Y, Zhou, et al |
American Journal of Emergency Medicine |
Clinical data| Données cliniques |
This study aimed to investigate chest computed tomography (CT) findings associated with severe COVID-19 pneumonia in
the early recovery period. Fibrous stripes and GGO are common CT signs in critically ill patients with COVID-19 pneumonia in the early recovery period. Signs of pulmonary fibrosis in survivors should be carefully monitored. |
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Farias, DLC, Prats, et al |
Revista Brasileira de terapia intensiva |
RCT |
INTRODUCTION: Pro-inflammatory markers play a significant role in the disease severity of patients with COVID-19. Thus,
anti-inflammatory therapies are attractive agents for potentially combating the uncontrolled inflammatory cascade in these patients. We designed a trial testing tocilizumab versus standard of care intending to improve the outcomes by inhibiting interleukin-6,
an important inflammatory mediator in COVID-19. METHODS AND ANALYSIS: This open-label multicentre randomized controlled trial will compare clinical outcomes of tocilizumab plus standard of care versus standard of care alone in patients with moderate to severe
COVID-19. Two of the following four criteria are required for protocol enrolment: D-dimer > 1,000ng/mL; C reactive protein > 5mg/dL, ferritin > 300mg/dL, and lactate dehydrogenase > upper limit of normal. The primary objective will be to compare the clinical
status on day 15, as measured by a 7-point ordinal scale applied in COVID-19 trials worldwide. The primary endpoint will be assessed by an ordinal logistic regression assuming proportional odds ratios adjusted for stratification variables (age and sex). ETHICS
AND DISSEMINATION: The TOCIBRAS protocol was approved by local and central (national) ethical committees in Brazil following current national and international guidelines/directives. Each participating center had the study protocol approved by their institutional
review boards before initiating protocol enrolment. The data derived from this trial will be published regardless of the results. If proven active, this strategy could alleviate the consequences of the inflammatory response in COVID-19 patients and improve
their clinical outcomes. INTRODUçÃO: Os marcadores pró-inflamatórios desempenham papel importante na severidade de pacientes com COVID-19. Assim,
terapêuticas anti-inflamatórias são agentes interessantes para potencialmente combater a cascata inflamatória descontrolada em tais pacientes. Delineamos um ensaio para testar tocilizumabe em comparação com o tratamento padrão, tendo como objetivo melhorar
os desfechos por meio da inibição da interleucina 6, um importante mediador inflamatório na COVID-19. MÉTODOS E ANÁLISES: Este será um estudo aberto multicêntrico, randomizado e controlado, que comparará os desfechos de pacientes tratados com tocilizumabe
mais tratamento padrão com o tratamento padrão isoladamente em pacientes com COVID-19 moderada a grave. Como critérios de inclusão, serão exigidos dois dos quatro critérios a seguir: dosagens de dímero D acima de 1.000ng/mL, proteína C-reativa acima de 5mg/dL,
ferritina acima de 300mg/dL e desidrogenase lática acima do limite superior do normal. O objetivo primário será comparar a condição clínica no dia 15, conforme avaliação por meio de escala ordinal de 7 pontos aplicada nos estudos de COVID-19 em todo o mundo.
O desfecho primário será avaliado por regressão logística ordinal assumindo razões de propensão proporcionais ajustadas pelas variáveis de estratificação (idade e sexo). ÉTICA E DISSEMINAçÃO: O TOCIBRAS foi aprovado pelos comitês de ética locais e central
(nacional) do Brasil em conformidade com as atuais diretrizes e orientações nacionais e internacionais. Cada centro participante obteve aprovação do estudo por parte de seu comitê de ética em pesquisa, antes de iniciar as inscrições no protocolo. Os dados
derivados deste ensaio serão publicados independentemente de seus resultados. Se tiver sua efetividade comprovada, esta estratégia terapêutica poderá aliviar as consequências da resposta inflamatória na COVID-19 e melhorar os resultados clínicos. |
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Mortality among Adults Ages 25-44 in the United States During the
COVID-19 Pandemic |
Faust, JeremyS, Krumholz, et al |
medRxiv |
Epidemiology| Épidémiologie |
We performed an observational cohort study using public data from the National Center for Health Statistics at the
CDC, and CDC Wonder. As of September 6, 2020, 74,027 all-cause deaths occurred among persons ages 25-44 years during the period from March 1st to July 31st, 2020, 14,155 more than during the same period of 2019, a 23% relative increase (incident rate ratio
1.23; 95% CI 1.21-1.24), with a peak of 30% occurring in May (IRR 1.30; 95% CI 1.27-1.33). In HHS Region 2 (New York, New Jersey), HHS Region 6 (Arkansas, Louisiana, New Mexico, Oklahoma, Texas), and HHS Region 9 (Arizona, California, Hawaii, Nevada), COVID-19
deaths exceeded 2018 unintentional opioid overdose deaths during at least one month. Combined, 2,450 COVID-19 deaths were recorded in these three regions during the pandemic period, compared to 2,445 opioid deaths during the same period of 2018. |
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Fauzi, MFM, Yusoff, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
This study aims to estimate the level of doctors’ fatigue, recovery, depression, anxiety, and stress, and exploring
their association with work demands and recovery experiences. This was a cross-sectional study among all medical doctors working at all government health facilities in Selangor, Malaysia. Data were collected in May 2020 immediately following the COVID-19 contagion
peak in Malaysia by using self-reported questionnaires through an online medium. The highest magnitude of work demands was mental demand while the lowest magnitude of recovery experiences was detachment. Participants reported a higher acute fatigue level than
chronic fatigue and intershift recovery. The majority of them had no depression (69.0%), no anxiety (70.3%), and no stress (76.5%). Higher work demands and lower recovery experiences were generally associated with adverse mental health. |
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Fernando, E, Surjandy, et al |
Advances in Science, Technology and Engineering Systems |
Public Health response| Interventions de santé publique |
This study aims to analyze a person's intention in using self-service technology (SST) services during the pandemic
COVID-19. The research framework of this research consists of several factors and indicators, namely efficiency (4 indicators), Reliability (4 indicators), security (3 indicators), Convenience (3 indicators), Ease of use (4 indicators). This study uses an
online survey with google form for users of self-service technology services in 5 major cities in Indonesia. Dissemination of the survey for three months, and the obtained were 100 respondents valid. The results of this study found two factors that influence
perceived usefulness, namely: efficiency and reliability, and found three factors that did not have an impact, namely Security factors, Convenience Factors, Perceived Ease of use, and Service Trust do not have an impact on perceived usefulness. This result
is a very interesting finding because during the period pandemic COVID-19. |
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SARS-CoV-2 induces inflammasome-dependent pyroptosis and downmodulation
of HLA-DR in human monocytes |
Ferreira, AndréC, Soares, et al |
medRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
Here, we show that SARS-CoV-2 induces inflammasome activation and cell death by pyroptosis in human monocytes, experimentally
infected and from patients under intensive care. Pyroptosis was dependent on caspase-1 engagement, prior to IL-1b production and inflammatory cell death. Monocytes exposed to SARS-CoV-2 downregulate HLA-DR, suggesting a potential limitation to orchestrate
the immune response. Our results originally describe mechanisms by which monocytes, a central cellular component recruited from peripheral blood to respiratory tract, succumb to control severe 2019 coronavirus disease (COVID-19). |
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Fowler, VeronicaL, Armson, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study describes the validation of a new rapid SARS-CoV-2 RT-LAMP assay for use on extracted RNA or directly from
swab offering an alternative diagnostic pathway that does not rely on traditional reagents that are often in short supply during a pandemic. Analytical specificity (ASp) of this new RT-LAMP assay was 100% and analytical sensitivity (ASe) was between 1x101
and 1x102 copies per reaction when using a synthetic DNA target. The overall diagnostic sensitivity (DSe) and specificity (DSp) of RNA RT-LAMP was 97% and 99% respectively, relative to the standard of care rRT-PCR. |
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SARS-CoV-2 seroprevalence in healthcare workers at a frontline hospital in Tokyo |
Fukuda, Hiroshi, Seyama, et al |
Research Square prepub |
Epidemiology| Épidémiologie Immunology | Immunologie |
The aim of this study was to assess the seroprevalence of SARS-CoV-2 in HCWs working in a frontline hospital in Tokyo,
Japan. In this observational cohort study, screening was offered to agreed HCWs, including medical, nursing, and others, as part of a mandatory health checkup. The screening test results and clinical characteristics of the participants were recorded. The antibody
seroprevalence among the 4,147 participants screened from July 6 to August 21 2020, was 0.34 % (14/4,147). There was no significant difference in seroprevalence between frontline HCWs with a high exposure risk and HCWs in other settings with a low exposure
risk. Of those seropositive for SARS-CoV-2, 64% (9/14) were not aware of any symptoms and had not previously been diagnosed with COVID-19. |
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Gagiannis, D, Steinestel, et al |
Frontiers in Immunology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Since we observed similarities between COVID-19 and interstitial lung disease in connective tissue disease (CTD-ILD),
we investigated features of autoimmunity in SARS-CoV-2-associated respiratory failure. Methods: We prospectively enrolled 22 patients with RT-PCR-confirmed SARS-CoV-2 infection and 10 patients with non-COVID-19-associated pneumonia. Full laboratory testing
was performed including autoantibody (AAB; ANA/ENA) screening using indirect immunofluorescence and immunoblot. Results: Thirteen (59.1%) patients developed acute respiratory distress syndrome (ARDS), and five patients (22.7%) died from the disease. ENA immunoblots
were detected in 11/13 COVID-19 patients with ARDS, in 1/9 COVID-19 patients without ARDS and in 4/10 patients with non-COVID-19-associated pneumonias. Our findings indicate that autoimmune mechanisms determine both clinical course and long-term sequelae
after SARS-CoV-2 infection, and the presence of autoantibodies might predict adverse clinical course in COVID-19 patients. |
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Gallioli, A, Albo, et al |
Urology |
Healthcare Response | Réponse des soins de santé |
Objective: To quantify and characterize the burden of urological patients admitted to emergency department (ED) in
Lombardy during Italian COVID-19 outbreak, comparing it to a reference population from 2019. Methods: We retrospectively analysed all consecutive admissions to ED from 1 January to 9 April in both 2019 and 2020. Results: The number of urological diagnoses
in ED was inversely associated to COVID-19 diagnoses. The average access per day was significantly lower after 10 March 2020, compared to reference period. From 11 March 2020, the inappropriate admissions to ED were reduced. |
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Gao, W, Chen, et al |
Virol J |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
OBJECTIVE: We aimed to describe the features of 220 nonemergency (mild or common type) COVID-19 patients from a shelter
hospital, as well as evaluate the efficiency of antiviral drug, Arbidol in their disease progressions. METHODS: Basic clinical characteristics were described and the efficacy of Arbidol was evaluated based on gender, age, maximum body temperature of the patients.
RESULTS: Basically, males had a higher risk of fever and more onset symptoms than females. Arbidol could accelerate fever recovery and viral clearance in respiratory specimens, particularly in males. Arbidol also contributed to shorter hospital stay without
obvious adverse reactions. |
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Drug-induced QT prolongation in COVID-19 pneumonia: influence on in-hospital survival |
García-Rodríguez, D, Remior, et al |
Revista espanola de cardiologia |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
Our objective was to know the evolution of the QT interval at the beginning of admission and its relationship with
the drug combinations used in the treatment of COVID-19 pneumonia. All patients admitted to our center for COVID-19 pneumonia at the beginning of the pandemic (March 2020) were retrospectively included with a baseline electrocardiogram (ECG) and 48 h after
the start of treatment. 226 patients were enrolled between March 1 and 20, 2020. The most widely used specific therapeutic regimen was double treatment with HCQ and lopinavir -ritonavir (LPV-r) (n = 111, 68.9%), followed by triple treatment with HCQ, LPV /
r and azithromycin or a quinolone (n = 30, 18.6%). In general, the QTc interval at 48 h was significantly longer than at admission. No significant differences were found in iQTc or QTc at 48 h between the different drug combinations. At one month of follow-up,
survival was similar between the highest-risk patients and those with a non-prolonged QT interval. There were no differences in the need for admission to the intensive care unit. This series is consistent with previous ones and shows a prolongation of the
QT interval in patients treated with HCQ and azithromycin for COVID-19 pneumonia. |
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Garrido, JoséM, Martínez-Rodríguez, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this article, we present a mathematical SEIR model focused on analysing the transmission dynamics of COVID-19, the
patients circulating in the hospitals and evaluating the effects of health policies and vaccination on the control of the pandemic. We tested the model using registered cases and population data from the province of Granada (Spain), that represents a population
size near 1 million citizens with low density of population and low prevalence. After calibrating the model with the data obtained from 15 March to 22 September 2020, we simulate different vaccination scenarios - including effectiveness and availability date
- in order to study the possible evolution of the disease. The results show that: 1) infected will increase until 5.6\% - 7.4\% of the total population over next 3-4 months, 2) vaccination seems not to be enough to face the pandemic and other strategies should
be used; 3) we also support the claim of the WHO about the effectiveness of the vaccine, that should be, at least, of 50\% to represent a substantial progress against the COVID-19; 4) after the 2nd wave, the return to normal life should be controlled and gradual
to avoid a 3rd wave. |
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Généreux, Mélissa, Schluter, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
Objective: To examine how the psychological response to the pandemic varies across countries and identify which risk/protective
factors contribute to this response. Methods : An online survey was conducted from May 29-June 12, 2020, among a multinational sample of 8,806 adults from eight countries/regions (Canada, United States, England, Switzerland, Belgium, Hong Kong, Philippines,
New Zealand). Probable generalized anxiety disorder (GAD) and major depression episode (MDE) were assessed. Findings: Probable GAD and MDE were indicated by 21.0% and 25.5% of the respondents, respectively, with an important variation according to countries/regions.
Several factors were positively associated with a probable GAD or MDE, including (in descending order of importance) weak sense of coherence (SOC), lower age, false beliefs, isolation, threat perceived for oneself/family, mistrust in authorities, stigma, threat
perceived for country/world, financial losses, being a female, and having high level of information about COVID-19. Having a weak SOC yielded the highest adjusted odds ratio for probable GAD or MDE |
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Geretti, AM, Stockdale, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We compared the presentation characteristics and outcomes of adults with and without HIV who were hospitalized with
COVID-19 at 207 centers across the United Kingdom and whose data were prospectively captured by the ISARIC WHO CCP study. METHODS: We used Kaplan-Meier methods and Cox regression to describe the association between HIV status and day-28 mortality, after separate
adjustment for sex, ethnicity, age, hospital acquisition of COVID-19 (definite hospital acquisition excluded), presentation date, ten individual comorbidities, and disease severity at presentation (as defined by hypoxia or oxygen therapy). RESULTS: At presentation,
HIV-positive people were younger (median 56 versus 74 years; p<0.001) and had fewer comorbidities, more systemic symptoms and higher lymphocyte counts and C-reactive protein levels. The cumulative day-28 mortality was similar in the HIV-positive vs. HIV-negative
groups, but in those under 60 years of age HIV-positive status was associated with increased mortality. HIV-positive status was associated with an increased risk of day-28 mortality among patients hospitalized for COVID-19. |
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Ghandour, R, Ghanayem, et al |
Annals of Global Health |
Public Health response| Interventions de santé publique |
Objectives: To assess the prevalence and predictors of distress and insecurity among Birzeit University’s community
during the COVID-19 pandemic and lockdown. Methods: An online survey completed in March-April 2020 using standardized and previously validated distress and insecurity scales. The survey was placed on the University portal accessed by students, faculty and
employees, and was sent by email to faculty and employees. Data were weighted to reflect the University community’s distribution. Findings: Prevalence of moderate/high distress and insecurity were 40% and 48% respec-tively. Multiple logistic regression revealed
that women, those under 35 years old and those with worse reported income, had significantly higher odds of distress and insecurity compared to their counterparts. Undergraduate students or living with a person at home with high risk of illness with COVID-19
were associated with higher odds of distress compared to their counterparts. A COVID-19 worry score was significantly associated with higher odds of distress and insecurity. |
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Ghimire, C, Acharya, et al |
Journal of the Nepal Medical Association |
Public Health response| Interventions de santé publique |
Methods: This is a descriptive cross-sectional, questionnaire-based, online survey by convenience sampling. The prevalence
of different types of interpersonal violence with socio-demographic factors, substance use, and overall mental wellbeing was assessed by using descriptive statistical tests. Results: There were 100 (18.0%) participants who reported being a victim of interpersonal
violence and 101 (18.2%) participants who reported being a perpetrator during the lockdown. The victims of violence were more likely to be living with their spouse alone. The victims and perpetrators were also more likely to have increased alcohol and tobacco
use. More number of victims and perpetrators had lower mental wellbeing scores on the WHO wellbeing index. |
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Ghosh, R, Chakraborty, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study, we have adopted computational approaches to understand these aspects. Six well-known corticosteroids
(cortisone, hydrocortisone, prednisolone, methylprednisolone, betamethasone and dexamethasone) and two repurposed drugs (darunavir and lopinavir) against COVID-19 were subjected for molecular docking studies. Two of them (betamethasone and dexamethasone) were
selected by comparing their binding affinities with selected repurposed drugs toward Mpro. Betamethasone and dexamethasone interacted with both the catalytic residues of Mpro (His41 and Cys145). Molecular dynamics studies further revealed that these two Mpro-corticosteroid
complexes are more stable, experience less conformational fluctuations and more compact than Mpro-darunavir/lopinavir complexes. These findings were additionally validated by MM-GBSA analysis. This study provides corroboration for execution of anti-COVID-19
activity of dexamethasone. |
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Characterization of Myocardial Injury in Patients With COVID-19 |
Giustino, G, Croft, et al |
Journal of the American College of Cardiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objectives: This study sought to characterize the echocardiographic abnormalities associated with myocardial injury
and their prognostic impact in patients with COVID-19. Methods: We conducted an international, multicenter cohort study including 7 hospitals in New York City and Milan of hospitalized patients with laboratory-confirmed COVID-19 who had undergone transthoracic
echocardiographic (TTE) and electrocardiographic evaluation during their index hospitalization. Myocardial injury was defined as any elevation in cardiac troponin at the time of clinical presentation or during the hospitalization. Results: Overall, myocardial
injury was observed in 190 patients (62.3%). Compared with patients without myocardial injury, those with myocardial injury had more electrocardiographic abnormalities, higher inflammatory biomarkers and an increased prevalence of major echocardiographic abnormalities
that included left ventricular wall motion abnormalities, global left ventricular dysfunction, left ventricular diastolic dysfunction grade II or III, right ventricular dysfunction and pericardial effusions. |
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Goh, Yun Shan, Chavatte, et al |
SSRN- Lancet prepublication |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
Here, we developed a flow cytometry-based assay to detect SARS-CoV-2 Spike protein (S protein) antibodies in COVID-19
patients. The assay detected specific IgM and IgG in COVID-19 patients and also the acquisition of all IgG subclasses, with IgG1 being the most dominant. The antibody response was significantly higher at a later stage of the infection. Furthermore, asymptomatic
COVID-19 patients also developed specific IgM and IgG, with IgG1 as the most dominant subclass. Although the antibody levels were lower in asymptomatic infections, the assay was highly sensitive and detected 97% of asymptomatic infections. |
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Gonçalves, TJM, Gonçalves, et al |
Clinical Nutrition ESPEN |
Clinical data| Données cliniques |
Background & aim: Verify the prevalence of hypovitaminosis D and obesity in elderly patients infected by new coronavirus.
The patients developed severe symptoms and were admitted in intensive care unit (ICU) to receive invasive ventilation due to diagnosis of acute respiratory distress syndrome (ARDS). Methods: A cross-sectional descriptive study composed of elderly (age ≥ 60
years) admitted to the ICU. Results: The most prevalent comorbidities were hypertension (72.2%) and diabetes (40.9%). Prevalence of hypovitaminosis D with values of 25 OHD <30 ng/mL, < 20 ng/mL and <10 ng/mL was 93.8%, 65.9% and 21% respectively. The prevalence
of hypovitaminosis D (<30 ng/mL) in obese elderly was 94.2%. Hypovitaminosis D and obesity in elderly have a high prevalence in critically ill patients in ICU infected by the new coronavirus. |
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Good, MF, Hawkes, et al |
mBio |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
A mathematical model accounting for nonpermanent immunity and reinfection may provide additional insights into the
predicted behavior of the epidemic. On the basis of the SIRS model, we developed a system of ordinary differential equations to describe SARS-CoV-2 epidemic with waning immunity. We used the province of Alberta, Canada (population 4.3 million), with its vital
statistics as an example population, in which COVID-19 is introduced at time t = 0. Incorporating waning immunity into the model while holding all other conditions and parameters constant, we obtained quantitatively different estimates of the number of deaths
and the proportion of immune individuals. We show how immunity, depending on its durability, may work with current social practices to limit the spread of the virus. The number of deaths after 3 years was predicted to be 51,000 with rapidly waning immunity,
compared to 11,000 if immunity waned more slowly over 1 year, and 6,300 if permanent immunity was assumed. We further show that a vaccine that is 50% effective and taken by 50% of the population will prevent further loss of life, providing that social distancing
is still practiced and that immunity does not wane quickly. |
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Govil, N, Raol, et al |
International journal of pediatric otorhinolaryngology |
Healthcare Response | Réponse des soins de santé |
Objective: To describe the implementation of telemedicine in a pediatric otolaryngology practice during the coronavirus
disease 2019 (COVID-19) global pandemic. Methods: A descriptive paper documenting the development and application of telemedicine in a tertiary academic pediatric otolaryngology practice. Results: A total of 51 established patients were seen via telemedicine
within the first 2 weeks of telemedicine implementation. Seven (7) patients were no shows to the appointment. The median patient age was 5 years old, with 55% male patients. Common diagnoses for the visits included sleep disordered breathing/obstructive sleep
apnea (25%) and hearing loss (19.64%). Over half (50.98%) of visits were billed at level 4 visit code. |
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Greene, Talya, Harju-Seppanen, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
Objectives: The objectives of this study were to identify demographic, work-related and other predictors for clinically
significant psychological distress, including PTSD, depression, and/or anxiety during the COVID-19 pandemic in UK frontline health and social care workers (HSCWs), and to compare rates of PTSD, depression and anxiety across different groups of HCSWs. Design:
An online survey was conducted in the weeks following the initial peak in cases (27 May to 23 July 2020). ain outcome measures: PTSD was assessed using the PTSD subscale of the International Trauma Questionnaire (ITQ); Depression assessed using the Patient
Health Questionnaire-9 (PHQ-9); Anxiety was assessed using the Generalized Anxiety Disorder Scale (GAD-7). Results: Over 57% of respondents met the threshold for clinically significant PTSD, anxiety or depression, and symptom levels were reasonably high and
comparable across occupational groups. Participants who were more concerned about infecting others, who felt they could not talk with their managers, who reported feeling stigmatised due to their role and who had not had reliable access to personal protective
equipment (PPE) were more likely to meet criteria for a clinically significant mental disorder. Being redeployed during the pandemic, and having had COVID were associated with a higher likelihood of meeting criteria for PTSD. |
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Grenache, DG, Ye, et al |
J Appl Lab Med |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
We sought to correlate the antibodies detected by an automated chemiluminescent immunoassay with NAbs. METHODS: Residual
serum samples from 35 patients that had a positive antibody test using the LIAISON® SARS-CoV-2 S1/S2 IgG chemiluminescent immunoassay and two antibody-negative control sera were tested for NAbs using a plaque reduction neutralization test (PRNT). RESULTS:
NAbs were detected in 66% (23/35) of the antibody-positive samples. An immunoassay signal cutoff of > 41 AU/mL was 91% sensitive and 92% specific for the detection of NAbs. |
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Gubler, DA, Makowski, et al |
Journal of Happiness Studies |
Public Health response| Interventions de santé publique |
The present study examined how neuroticism, extraversion, and emotion regulation were related to loneliness and well-being
during 6 weeks of major public life restrictions in the Covid-19 pandemic in Switzerland. Cross-sectional results from 466 participants showed that neuroticism and emotion regulation strategies were associated with higher loneliness and lower well-being. .
For introverts, maladaptive cognitive strategies such as rumination or catastrophizing were related to higher levels of loneliness. For extraverts, emotion suppression was related to lower levels of affective well-being. Individuals with low maladaptive regulation
reported higher well-being the longer the public life restrictions were in place at the time of study participation. |
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Guglielmi, S, Dotti Sani, et al |
International Journal of Sociology and Social Policy |
Public Health response| Interventions de santé publique |
Design/methodology/approach: The article relies on structural equation models (SEMs) based on data from ResPOnsE COVID-19,
a rolling cross-section (RCS) survey carried out in Italy from April to June 2020. Findings: The authors’ findings show the existence of multiple pathways of confidence at the national and local level. Confidence in the institutions is positively associated
with support for the performance of the Prime Minister and that of the regional institutions in the North West, which in turn, raises the likelihood of following the restrictive measures. However, in the same regions, a good appraisal of the regional system's
performance also had a direct positive effect on the perception of being safe from the virus, decreasing adherence to the restrictive measures. Finally, the direct effect of confidence in the institutions on compliance is negative. |
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33036676; Can COVID-19 Mortality be Predicted in the Emergency Room? |
Güneysu, F, Guner, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
OBJECTIVE: To investigate the association of white blood cell (WBC) counts, neutrophil, platelets, lymphocyte counts,
C-reactive protein (CRP), neutrophil / lymphocyte ratio (NLR), derived NLR ratio (d-NLR), and platelet / lymphocyte ratio (PLR) at the time of first admission for mortality caused by COVID-19. STUDY DESIGN: Descritive, analytical study. PLACE AND DURATION
OF STUDY: Department of Emergency Medicine, Sakarya University Training and Research Hospital, Turkey from March 2020 to May 2020. METHODOLOGY: One hundred and sixty-nine patients with the diagnosis of Covid-19 were retrospectively reviewed. Patients were
divided into two groups as survivors and non-survivors. RESULTS: There was a statistically significant association between neutrophil, lymphocyte, CRP, NLR, d-NLR and PLR values with mortality status of patients. |
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Hadjicharalambous, Demetris, Athanasiadi-Charchanti, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
The purpose of this study is to examine how working mothers reacted during the COVID-19 pandemic and how the state
imposed quarantine affected their quality of life, their health, and their resilience. We designed and carried out a web based survey in Cyprus with 208 participants, all working mothers. We administered two questionnaires. The participants answered the questionnaires
on the Internet platform Enklikanketa, from May 20 to May 30, 2020. The results showed that the state-imposed measures of social isolation in the form of quarantine had a negative impact on the psychological resilience and the quality of life of younger working
mothers, of single working mothers, and of those working mothers who were residing in rural areas at the time. Working mothers who belonged to older age groups, those who continued to pursue activities and hobbies during the quarantine, and mothers who maintained
a higher quality of life were affected less by social isolation measures. |
|
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SARS-CoV-2 presence in the saliva, tears and cerumen of COVID-19 patients |
Hanege, FM, Kocoglu, et al |
Laryngoscope |
Clinical data| Données cliniques |
The aim of this study was to evaluate the presence of the virus in different bodily secretions as a potential source
of viral spread among patients infected with SARS-CoV-2. METHODS: The study included 38 COVID-19 patients with a positive real time polymerase chain reaction (RT-PCR) test result for SARS-CoV-2, obtained from the combined nasopharyngeal-oropharyngeal swab
samples. Saliva, tear and cerumen samples were taken from the patients within 72 hours of the first RT-PCR test. SARS-CoV-2 N1 and N2 gene regions were studied with single-step RT-PCR in all samples. RESULTS: Among the studied samples, the highest positivity
rate was in saliva (76.3%) followed by tears (55.3%) and cerumen (39.5%). Viral load in saliva was also significantly higher compared to tears and cerumen, while there was no significant difference between tears and cerumen. |
|
Haraszti, S, Sendil, et al |
Am J Case Rep |
Clinical data| Données cliniques |
This report describes an unusual presentation of AGEP following treatment with cefepime for a urinary tract infection
in a 78-year-old man who was found to be positive for SARS-CoV-2 infection, but was not treated with hydroxychloroquine. |
|
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DenseNet Convolutional Neural Networks Application for Predicting COVID-19 Using CT Image |
Hasan, Najmul, Bao, et al |
Research Square prepub |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This paper presents a promising technique of predicting COVID-19 patients from the CT image using convolutional neural
networks (CNN). The results outperformed 92% accuracy, with 95% recall showing good performance for the identification of COVID-19. |
|
Case Series of COVID-19 Asymptomatic Newborns With Possible Intrapartum Transmission of SARS-CoV-2 |
Hascoët, JM, Jellimann, et al |
Frontiers in Pediatrics |
Transmission Clinical data| Données cliniques |
This report aimed to bring new information about presentation that could modify precautionary measures for infants
born of mothers with a remote history of COVID-19. We report two infants with possible maternofetal transmission, and four mothers without immunologic reactions. These observations raise concerns regarding contamination risk by asymptomatic newborns and the
efficacy of immunologic reactions in pregnant mothers, questioning the reliability of antibody testing during pregnancy. |
|
Early estimates of the impact of the COVID-19 pandemic on GDP: a case study of Saudi Arabia |
Havrlant, D, Darandary, et al |
Applied Economics |
Economics | Économie |
Authors discuss how Saudi Arabian government’s discretionary measures to contain the COVID-19 infection, and how will
suffer more than others. The study shows how to accommodate a qualitative shift in economic conditions given the still-evolving pandemic. The negative impact on headline GDP in 2020 is estimated to range from −4.8% to −9.8% compared to the baseline level,
while the government’s fiscal countermeasures result in a positive effect of some 2.5% in real GDP. We consider the potential situation of a second wave of the infection that would enforce a protracted lockdown and imply second-round effects. |
|
“Floating egg” appearance of para-pneumonic effusion in a COVID-19 patient |
Haynes, S, Chan, et al |
Indian Journal of Anaesthesia |
Clinical data| Données cliniques |
In this letter to the editor, authors present a previously unreported finding in a coronavirus disease 2019 (COVID-19)
patient with para-pneumonic effusion. This report highlights the presence of a prominent coagulum with appearance resembling a floating egg in an exudative para-pneumonic pleural effusion caused by COVID-19. |
|
Hectors, SJ, Riyahi, et al |
Abdom Radiol (NY) |
Modelling/ prediction| Modélisation/prédiction Clinical data| Données cliniques |
The purpose of this study was to develop and externally validate a multivariate prediction model for the prediction
of acute kidney injury (AKI) in COVID-19, based on baseline renal perfusion from contrast-enhanced CT together with clinical and laboratory parameters. Results show diminished renal perfusion preceding AKI and a promising role of CAEI, combined with laboratory
and demographic markers, for prediction of AKI in COVID-19. |
|
|
Hegde, S, Khan, et al |
Open Heart |
Clinical data| Données cliniques |
Authors discuss the clinical characteristics and outcomes of patients with COVID-19 complicated by secondary Takotsubo
cardiomyopathy (TC). Early identification of patients with COVID-19 who are at higher risk for developing secondary TC is important for the prevention of complications, and thus improved outcomes. |
|
|
Heidinger, T, Richter, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
This study provides a direct comparison of reported loneliness before and during the pandemic using 1:1 propensity
score matching (PSM) on a pre- and a peri-pandemic sample of elderly (60+ years) individuals from Lower Austria, a county of Austria (Europe). Although the reported loneliness remained rather low, this result illustrated the effect of the “new normal” under
COVID-19. |
|
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Evaluating the effectiveness of COVID-19 bluetooth-based smartphone contact tracing applications |
Hernández-Orallo, E, Calafate, et al |
Applied Sciences (Switzerland) |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This paper evaluates the effectiveness of recently developed contact tracing smartphone applications for COVID-19 that
rely on Bluetooth to detect contacts. Results show that smartphone contact tracing can only be effective when combined with other mild measures that can slightly reduce the reproductive number (R0) (for example, social distancing). |
|
Heuts, S, Ubben, et al |
Journal of cardiothoracic and vascular anesthesia |
Clinical data| Données cliniques |
Patients with coronavirus disease 2019 (COVID-19) are prone to pulmonary artery hypertension (PAH) and right ventricular
pressure overload due to severe bilateral infiltrates, high ventilation pressures, persistent hypoxemia, pulmonary fibrosis, and/or pulmonary embolism. In patients on extracorporeal membrane oxygenation (ECMO), this potentially leads to increased recirculation.
In the current report, the authors present a case in which continuous inhaled nitric oxide (iNO)-enriched ventilation was effective in terms of PAH and recirculation reduction in a COVID-19 patient on veno-venous ECMO. © 2020 The Authors |
|
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Older age groups and country-specific case fatality rates of COVID-19 in Europe, USA and Canada |
Hoffmann, C, Wolf, et al |
Infection |
Epidemiology| Épidémiologie |
The purpose of this study was to evaluate the association between the percentages of older age groups among confirmed
SARS-CoV-2 infections and the country-specific case fatality rate (CFR). Data from 20 European countries and the USA and Canada showed that the variance of crude CFR of COVID-19 is predominantly (80-96%) determined by the proportion of older individuals who
are diagnosed with SARS-CoV-2. |
|
32750974; COVID-19 Optimizer Algorithm, Modeling and Controlling of Coronavirus Distribution Process |
Hosseini, E, Ghafoor, et al |
IEEE journal of biomedical and health informatics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This article first proposes a novel COVID-19 optimizer Algorithm (CVA) to cover almost all feasible regions of the
optimization problems. Extensive simulations using several optimization schemes show that the CVA technique performs best with up to 15%, 37%, 53% and 59% increase compared with Volcano Eruption Algorithm (VEA), Gray Wolf Optimizer (GWO), Particle Swarm Optimization
(PSO) and Genetic Algorithm (GA), respectively. |
|
Hübner, M, Zingg, et al |
PLoS One |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to illustrate the timeline of actions taken and to measure and analyze their impact on surgical
patients. While allowing for maximal care of Covid-19 patients during the pandemic, the shift of resources limited the access to elective surgical care, with less impact on cancer care. |
|
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Dental practice during COVID-19 in Nepal: A descriptive cross-sectional study |
Humagain, M, Humagain, et al |
Journal of the Nepal Medical Association |
Healthcare Response | Réponse des soins de santé |
This research was done to find out the impact of COVID-19 on dentists, patients, and dental practice in Nepal. Dentists,
patients, and dental practice are severely affected by the COVID-19. |
|
Ibrahim, MutasimE, Al-Aklobi, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Authors investigated the epidemiologic, clinical, and laboratory findings of COVID-19 infected patients to identify
the effective indicators correlated with the disease. The common symptoms found in this study could be useful for identifying potential COVID-19 patients. |
|
|
Iglesias, Nestor Gabriel, Gebhard, et al |
medRxiv |
Epidemiology| Épidémiologie Surveillance |
In this study we measured SARS-CoV-2 RNA from a surface water source in a low-income settlement. Authors observe for
this community that measurements of SARS-CoV-2 concentrations in surface water contaminated by sewage can be considered as an estimation of changes in COVID-19 prevalence on a population level. |
|
|
Irawan, MZ, Rizki, et al |
Transportation Research Interdisciplinary Perspectives |
Public Health response| Interventions de santé publique |
This study will be the first to examine the participation intention of physical activities if new normal conditions
are implemented in Indonesia. Excluding non-grocery shopping, there was also no significant difference in activity participation intention between people living in the Greater Jakarta as epicentrum of COVID-19 in Indonesia and people living outside the Greater
Jakarta. |
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Implementation of Convolutional Neural Network Approach for COVID-19 Disease Detection |
Irmak, E |
Physiol Genomics |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper two novel, powerful and robust Convolutional Neural Network (CNN) architectures are designed and proposed
for two different classification tasks using publicly available datasets. This study is the first study to detect COVID-19 disease from given chest X-ray images, using CNN whose hyper parameters are automatically determined by the Grid Search. |
|
Jaman, JH, Abdulrohman, et al |
Advances in Science, Technology and Engineering Systems |
Public Health response| Interventions de santé publique |
In this paper, authors aim to analyze the experience of online transportation consumers using Support Vector Machine.
The highest accuracy results occurred in the normal era with a ratio of 10% as test data and 90% as its training data on linear and sigmoid kernels of 0.8060 while the COVID-19 era only got the highest accuracy of 0.59 in linear kernels with a ratio of 60:40. |
|
|
Jangra, Sonia, De Vrieze, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins |
The search for vaccines that protect from severe morbidity and mortality as a result of infection with severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19) is a race against the clock and the virus. Results underscore the potential use of IMDQ-PEG-CHOL as an adjuvant to achieve protection after single immunization
with recombinant protein and inactivated virus vaccines against respiratory viruses, such as SARS-CoV-2 and influenza viruses. |
|
|
Analysis of covid-19 burden, epidemiology and mitigation strategies in muslim majority countries |
Jardine, R, Wright, et al |
Eastern Mediterranean Health Journal |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study aimed to analyse COVID-19 burden, epidemiology and mitigation strategies in Muslim-majority countries. The
analysis indicates wide diversity in the COVID-19 response across Muslim majority countries with clear indication that functional democracies were able to contain the epidemic significantly better than nondemocratic regimes. |
|
Jechow, A, Hölker, et al |
Remote Sensing |
Public health interventions*| Interventions de santé publique |
In this work, authors investigated the impact of the lockdown caused by the COVID-19 pandemic on the urban skyglow
of Berlin, Germany. This is the first reported impact of COVID-19 on artificial skyglow and authors conclude that air pollution should shift more into the focus of light pollution research. |
|
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Mental Health During the COVID-19 Pandemic in the United States: Online Survey |
Jewell, JS, Farewell, et al |
JMIR Form Res |
Public Health response| Interventions de santé publique |
This research focused on assessing the mental health status of adults in the United States during the early weeks of
an unfolding pandemic. Findings suggest that many US residents are experiencing high stress, depressive, and anxiety symptomatology, especially those who are underinsured, uninsured, or unemployed. |
|
How maternal and neonatal services at the community level during the COVID-19 pandemic
in Indonesia? |
Johariyah, Zubaedah, DSN, et al |
Systematic Reviews in Pharmacy |
Healthcare Response | Réponse des soins de santé |
Objectives: This study aimed to analyze and describe the implementation of maternal and neonatal care in Indonesian
communities during the COVID-19 pandemic. Methods: The study used a cross-sectional design. A sample of 132 midwives was enrolled with snowball sampling technique. Data analysis with frequency and percentage used univariate analysis. Results: Maternal and
neonatal care in the community during the COVID-19 period was done well (53%). |
|
John-Henderson, N |
Sleep Health |
Public Health response| Interventions de santé publique |
The objective of this study was to investigate whether childhood trauma predicts changes in sleep quality following
onset of the pandemic and test whether pandemic stress contributes to changes in sleep. In American Indians childhood trauma predicts greater declines in sleep quality associated with the onset of the COVID-19 pandemic, in part because greater psychological
stress related to COVID-19. |
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|
Joubert, Antoine, Andry, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Authors performed a cohort study to identify predictors of COVID-19 and dengue fever. Although prone to potential biases,
these data suggest that dengue may be more symptomatic than COVID-19 in a co-epidemic setting with higher dengue attack rates. |
|
|
Jutzi, CA, Willardt, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
People around the world have reacted to the COVID-19 threats in seemingly unrelated ways: From stockpiling yeast and
toilet paper to favoring nationalist ideas or endorsing conspiratorial beliefs. Authors hypothesized increased perceived COVID-19 threat to lead to a proximal threat response in the form of heightened behavioral inhibition. The results of this research hint
toward a common mechanism through which the seemingly unrelated reactions to COVID-19 can be explained. |
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Kabiraj, S, Gavli, et al |
Aerosol Science and Engineering |
Public health interventions*| Interventions de santé publique |
Authors tried to estimate the air quality improvement during the pre-lockdown period (January 1–March 23, 2020) by
comparing the lockdown period (March 24–May 31, 2020). This reduced level of air pollutants may help in the modification of all the environmental policies for better air quality in future. |
|
|
Kanoore Edul, VS, Caminos Eguillor, et al |
Journal of critical care |
Clinical data| Données cliniques |
The objective of this study was to assess the presence of sublingual microcirculatory and skin perfusion alterations
in COVID-19 pneumonia. COVID-19 patients showed an altered tissue perfusion. |
|
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Karna, ST, Panda, et al |
Indian Journal of Surgery |
Clinical data| Données cliniques |
This report describes the unusual progression of COVID-19 disease from pneumonia to a procoagulant state leading to
superior mesenteric artery thrombosis and subsequent gut ischemia necessitating emergency laparotomy. In the management of any patient with COVID-19 disease, authors advocate a comprehensive integrated approach with early recognition of digestive symptoms
and their timely intervention which should run parallel to the respiratory management. |
|
|
Khalifa, NEM, Taha, et al |
Journal of Nanoparticle Research |
Therapeutics| Thérapeutique |
In this paper, a deep learning model and machine learning methods for the classification of potential coronavirus treatments
on a single human cell is presented. The performance metrics strengthen the obtained results from the conducted experiments for the accuracy of treatment classification and treatment concentration level prediction. |
|
|
An evaluation of dermatology patients shielding during the COVID-19 outbreak |
Khan, SS, Marshall, et al |
Clin Exp Dermatol |
Healthcare Response | Réponse des soins de santé |
In order to understand the experience of our dermatology patients, in Greater Manchester, UK, who were advised to shield
we conducted a telephone questionnaire. Retrospective analysis of patient records/pharmacy lists revealed 1071 patients that met the British Association of Dermatologist’s criteria for shielding. |
|
The impact of social distancing on box-office revenue: Evidence from the COVID-19 pandemic |
Kim, IK |
Quantitative Marketing and Economics |
Economics | Économie |
In this paper, I study the short-run effect of social distancing due to the COVID-19 outbreak on movie demand and box-office
revenue. Using longitudinal data on the Korean movie theater industry, I first estimate a nested logit model of movie demand, and then quantify the revenue loss in the industry. Estimation results reveal that the revenue loss due to the decrease in underlying
movie demand is approximately 52 million dollars nationwide during the first five weeks after the outbreak, implying a 34 percent decrease in sales. The results also suggest an additional 42 million dollars were lost as the delay of some major movies lowered
the overall quality of available movies in the market. © 2020, Springer Science+Business Media, LLC, part of Springer Nature. |
|
Kimura, KS, Freeman, et al |
International Forum of Allergy and Rhinology |
Therapeutics| Thérapeutique RCT |
Authors started an open‐label randomized controlled trial (RCT) to evaluate the effect of nasal irrigation with hypertonic
saline (HTS) or saline with surfactant on upper respiratory symptoms and viral load. The interim analysis included the first 45 patients with completed symptom questionnaires, which included 17 patients in the on-intervention group, and 14 each in the nasal
irrigation with hypertonic saline groups (HTS and HTSS). Although the current study provides evidence to suggest that topical saline irrigation can reduce symptom burden in patients with COVID‐19, authors are not yet able to determine whether irrigations
affect viral load and/or shedding. |
|
|
Kline, A, Putnam, et al |
Diagnostic microbiology and infectious disease |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Nasopharyngeal flocked swabs placed in viral transport media (VTM) are the preferred collection methodology for respiratory
virus testing. Due to the rapid depletion of available reagents and swabs, we have validated an alternative swab placed in phosphate-buffered saline (PBS) for use in respiratory virus testing in a SARS-CoV-2 real-time polymerase chain reaction assay and a
multiplexed respiratory virus panel. We collected nasopharyngeal (NP) swabs and oropharyngeal (OP) swabs from 10 healthy volunteers. Flocked swabs were placed in VTM and alternative swabs in PBS. In this feasibility study, we show that NP collection is better
for detection of human material than OP collection, as measured by significantly lower RNase P gene cycle threshold values, and that a Dacron polyester swab in PBS shows equivalent detection of SARS-CoV-2 and RSV to a flocked swab in VTM in contrived specimens.
Diluted SARS-CoV-2–positive patient specimens are detectable for up to 72 h at 4 °C. © 2020 |
|
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33054033; Lymphocytic myocarditis in patients with COVID-19 (4 autopsy cases) |
Kogan, EA, Berezovsky, et al |
Arkhiv Patologii |
Clinical data| Données cliniques |
The paper describes 4 autopsy cases of myocarditis in elderly patients with confirmed coronavirus infection. It gives
the data of a morphological study of heart specimens and a detailed characterization of a myocardial infiltrate. An immunohistochemical study with cellular infiltrate typing was performed. The fact that lymphocytic viral myocarditis can develop in COVID-19
was morphologically and immunohistochemically confirmed. The features of myocarditis in COVID-19 are the development of the former in the presence of coronaritis and the possibility of its concurrence with lymphocytic endo- and pericarditis |
|
Konstantinou, Corina, Andrianou, et al |
medRxiv |
Public Health response| Interventions de santé publique |
We aimed to study changes in the environment, diet, behavior, personal hygiene, contacts, lifestyle choices and the
degree of compliance to NPI measures by primary school children in Cyprus at school and at home for two periods, i.e., before lockdown and during the school re-opening using the methodological context of the human exposome. A total of 1509 children from more
than 180 primary schools (out of 330 schools) in Cyprus were included. Median number of contacts per day at home, school and other places during weekdays was lower (p<0.001) in the post-lockdown period compared to the pre-lockdown period (5 vs 12, 10 vs 29
and 6 vs 14, respectively). Vulnerable contacts with children also decreased from 2[1, 3] in the pre-lockdown to 1[0, 2] in the post-lockdown period (p<0.001). Differences in sugary and ready-made food consumption, physical activity, screen time, digital communication
and hand hygiene were noted between the two periods. More than 72% of children complied with the NPI measures, with the exception of the decrease in number of vulnerable contact(s) indicator (48%). Eating meat more frequently post-lockdown and doing less physical
activity during school break post-lockdown were positively associated with increased time spent at home post-lockdown. Furthermore, the odds of compliance, as indicated by the time spent at home post-lockdown were lower with days elapsing from school re-opening,
living in smaller town and using antiseptic more frequently pre-lockdown. |
|
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Korkmaz, S, Aslan, et al |
Progress in Nutrition |
Public Health response| Interventions de santé publique |
The purpose of this study was to examine the changes in the selected physical and physiological properties of football
players in the long-term detraining stage during the pandemic period. Comparing the pretest-posttest results of the participants; the difference between the two measurements was statistically insignificant in terms of body weight, BMI, 30 m speed, and fatigue
index properties, while the difference in terms of body muscle mass, fat mass, fat ratio, waist-hip ratio, peak power, average power, minimum power and flexibility properties was significant. |
|
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Bilateral pulmonary emboli in a teenager with positive SARS-CoV-2 antibody |
Kotula, JJ, Balakumar, et al |
Pediatr Pulmonol |
Clinical data| Données cliniques |
Thromboembolic phenomena, particularly pulmonary emboli, have been described in adult patients with SARS-CoV-2 infection,
but have been less evident in children. We describe a case of a teenager with bilateral pulmonary emboli leading to cardiovascular collapse in the setting ofa positiveSARS-CoV-2 IgM antibody. |
|
The COVID-19 outbreak and approaches to performing EEG in Europe |
Krysl, D, Beniczky, et al |
Epileptic Disord |
Healthcare Response | Réponse des soins de santé |
Our objective was to outline the current situation regarding EEG-based investigations across Europe. A web-based survey
was distributed to centres within the European Reference Network on rare and complex epilepsies (ERN EpiCARE). At the time of completing the survey, inpatient video-EEGs had been stopped or restricted in most centres (61.7% vs. 36.2% for adults, and 38.3%
vs. 53.2% for children). Invasive investigations and epilepsy surgery were similarly affected. Acute EEGs continued to be performed, while indications for outpatient EEGs were limited and COVID-19 triage put in place. The strictness of measures varied according
to extent of the outbreak in a given country. The results indicate a profound impact of COVID-19 on neurophysiological diagnostics, especially inpatient video-EEGs, invasive investigations, and epilepsy surgery. |
|
Kushtanina, V, Vinel, et al |
European Societies |
Public Health response| Interventions de santé publique |
During the Covid-19 crisis, the residents of France were invited to stay at their homes. This representation of family
as a shelter in case of difficulties has been prevailing within French family policies since the 1980s. In this paper, we question this integrating role family played during the lockdown through an on-line survey carried out during the shutdown. A sample of
4300 persons sheds light on the experience of this exceptional period. Four main results are presented in the article. Firstly, the residents of France of our sample tended to join their partner or family members. Secondly, the regrouping was gender-related:
women were more often locked-downed with their relatives. Thirdly, this regrouping is linked to age–young people were more often welcomed in the households of their relatives than older adults or the elderly. And fourthly, the education level is also a relevant
factor of family reunification for the lockdown. © 2020 European Sociological Association. |
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|
Lalli, MA, Langmade, et al |
Clin Chem |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We developed a rapid colorimetric assay using reverse-transcription loop-mediated isothermal amplification (RT-LAMP)
optimized on human saliva samples without an RNA purification step. The optimized saliva pretreatment protocol enabled analytically sensitive extraction-free detection of SARS-CoV-2 from saliva by colorimetric RT-LAMP or RT-qPCR. In simulated samples, the
optimized RT-LAMP assay had a limit of detection of 59 (95% confidence interval: 44-104) particle copies per reaction. We highlighted the flexibility of LAMP assay implementation using three readouts: naked-eye colorimetry, spectrophotometry, and real-time
fluorescence. In a set of 30 clinical saliva samples, colorimetric RT-LAMP and RT-qPCR assays performed directly on pretreated saliva samples without RNA extraction had accuracies greater than 90%. |
|
|
33010487; Impact of the COVID-19 Outbreak on the management of patients with gynecological cancers |
Lamblin, G, Golfier, et al |
Gynecologie Obstetrique Fertilite et Senologie |
Healthcare Response | Réponse des soins de santé |
The main objective is to estimate the proportion of patients with treatment modifications. This is a multicenter prospective
study conducted in 3 university gynecological cancer departments (HCLyon, France) during the period of confinement (March 16 to May 11, 2020). Two hundred and five consecutive patients were included, average age 60.5 ± 1.0. 7 patients (3.4%) had SARS-Cov-2
infection, 2 patients died. One hundred and twenty-two patients (59.5%) had a treatment maintained, 72 patients (35.1%) postponed, 11 patients (5.4%) cancelled. Of the 115 (56.1%) planned surgeries, 40 (34.8%) postponed, 7 cancelled (6.1%). 9 patients (7.8%)
had a surgical modification. Of the 59 (28.8%) radiotherapy treatments scheduled, 24 (40.7%) postponed and 2 (3.4%) cancelled. Of the 56 (27.3%) chemotherapy treatment planned, 8 (14.3%) postponed and 2 (3.6%) cancelled. One hundred and forty-five patients
(70.7%) have been discussed in multidisciplinary meeting. One hundred and fifty-eight patients (77%) had a teleconsultation system. |
|
Lange, M, Joo, et al |
Annales Pharmaceutiques Francaises |
Healthcare Response | Réponse des soins de santé |
We carried out a postal-based survey to assess the psychological impact of COVID-19 in French owner community pharmacists
based on three validated self-report questionnaires: Perceived Stress scale, Impact of Event Scale-revised and Maslach Burnout Inventory. The sample consists of 135 community pharmacists. Twenty-three pharmacists reported significant post-traumatic stress
symptoms (17%). High burnout symptoms were found in 33 (25%), 46 (34.9%) and 4 (3%) participants. Females scored higher than males for all questionnaires (P = 0.01). |
|
|
Lanza, GA, De Vita, et al |
Europace |
Clinical data| Données cliniques |
We studied 324 consecutive patients admitted to our Emergency Department with a confirmed diagnosis of SARS-CoV-2 infection.
Standard 12-lead ECG recorded on admission was assessed for cardiac rhythm and rate, atrioventricular and intraventricular conduction, abnormal Q/QS wave, ST segment and T wave changes, corrected QT interval, and tachyarrhythmias. At a mean follow-up of 31
± 11 days, 44 deaths occurred (13.6%). Most ECG variables were significantly associated with mortality, including atrial fibrillation (P = 0.002), increasing heart rate (P = 0.002), presence of left bundle branch block (LBBB; P < 0.001), QRS duration (P <0
.001), a QRS duration of ≥110 ms (P < 0.001), ST segment depression (P < 0.001), abnormal Q/QS wave (P = 0.034), premature ventricular complexes (PVCs; P = 0.051), and presence of any ECG abnormality hazard ratio (HR) 4.58; 95% confidence interval (CI) 2.40-8.76;
P < 0.001]. At multivariable analysis, QRS duration (P = 0.002), QRS duration ≥110 ms (P = 0.03), LBBB (P = 0.014) and presence of any ECG abnormality (P = 0.04) maintained a significant independent association with mortality. |
|
|
Lau, YL, Ismail, et al |
Am J Trop Med Hyg |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
A simple and rapid reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay was developed for the
detection of SARS-CoV-2. The RT-LAMP assay was highly specific for SARS-CoV-2 and was able to detect one copy of transcribed SARS-CoV-2 RNA within 24 minutes. Assay validation performed using 50 positive and 32 negative clinical samples showed 100% sensitivity
and specificity. The RT-LAMP would be valuable for clinical diagnosis and epidemiological surveillance of SARS-CoV-2 infection in resource-limited areas as it does not require the use of sophisticated and costly equipment. |
|
|
Law, Kian Boon, Peariasamy, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Transmission |
The study aimed to reveal the real spreading pattern of COVID-19 by excluding incarcerated clusters in the modelling.
We extended the susceptible-infectious-removed (SIR) model to include an additional class for non-isolated active cases, which was assumed to impel the transmission of COVID-19 in the community. The presence of incarcerated clusters shadowed the dynamics of
transmission of COVID-19 with a lower reproduction number of 2.0. The proportion of non-isolated active cases increased slowly from 49.4% on 1 September 2020 to 60.3% on 8 October 2020. In the absence of incarcerated clusters, the dynamics of transmission
of COVID-19 appeared differently with a higher reproduction number of 2.3. The proportion of non-isolated active cases increased tremendously from 22.1% on 1 September 2020 to 63.7% on 8 October 2020. The tremendous increase of non-isolated active cases impelled
the dynamics of transmission of COVID-19 in the community following the Sabah state by-election campaigns and more inter-state travels. |
|
|
Transcriptomics-based drug repositioning pipeline identifies therapeutic
candidates for COVID-19 |
Le, BrianL, Andreoletti, et al |
bioRxiv |
Therapeutics| Thérapeutique |
The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug
repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We utilized three independent published studies to acquire or generate lists of differentially expressed genes between control and SARS-CoV-2-infected
samples. Using a rank-based pattern matching strategy based on the Kolmogorov-Smirnov Statistic, the signatures were queried against drug profiles from Connectivity Map (CMap). We validated sixteen of our top predicted hits in live SARS-CoV-2 antiviral assays
in either Calu-3 or 293T-ACE2 cells. Validation experiments in human cell lines showed that 11 of the 16 compounds tested to date (including clofazimine, haloperidol and others) had measurable antiviral activity against SARS-CoV-2. These initial results are
encouraging as we continue to work towards a further analysis of these predicted drugs as potential therapeutics for the treatment of COVID-19. |
|
Lee, S, Rozybakieva, et al |
Archives of the Balkan Medical Union |
Healthcare Response | Réponse des soins de santé RCT |
The study aimed at validating the effectiveness of Asimov’s coping strategy among a group of primary care physicians
in reducing emotional burnout. The assessment of the emotional burnout showed a high level of emotional burnout in both groups (p>0.05). After 6 months, emotional exhaustion (EE) (p=0.019) and depersonalization (DP) (p=0.028) indicators in the IG group were
reduced, in contrast to the CG group, except for the lack of personal achievement (PA) (p=0.067). However, after 12 months, indicators of EE and DP were decreased, at the same time the PA indicator was elevated in the IG group (p <0.05). The data of the study
based on the Lazarus questionnaire (12 months) showed the effectiveness of this method (p <0.05). |
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Lee, YR, Kang, et al |
Clinical and Molecular Hepatology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A total of 1,005 patients who were admitted to five tertiary hospitals in South Korea with laboratory-confirmed COVID-19
were included in this study. Clinical outcomes in COVID-19 patients with coexisting liver disease as well as the predictors of disease severity and mortality of COVID-19 were assessed. Of the 47 patients (4.7%) who had liver-related comorbidities, 14 patients
(1.4%) had liver cirrhosis. Liver cirrhosis was more common in COVID-19 patients with severe pneumonia than in those with non-severe pneumonia (4.5% vs. 0.9%, P=0.006). Compared to patients without liver cirrhosis, a higher proportion of patients with liver
cirrhosis required oxygen therapy; were admitted to the intensive care unit; had septic shock, acute respiratory distress syndrome, or acute kidney injury; and died (P<0.05). The overall survival rate was significantly lower in patients with liver cirrhosis
than in those without liver cirrhosis (log-rank test, P=0.003). Along with old age and diabetes, the presence of liver cirrhosis was found to be an independent predictor of severe disease (odds ratio, 4.52; 95% confidence interval CI], 1.20–17.02; P=0.026)
and death (hazard ratio, 2.86; 95% CI, 1.04–9.30; P=0.042) in COVID-19 patients. |
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|
Lenza, MP, Oyenarte, et al |
Angewandte Chemie - International Edition |
Coronavirology| Coronavirologie |
The glycan structures of the receptor binding domain of the SARS-CoV2 spike glycoprotein expressed in human HEK293F
cells have been studied by using NMR. The different possible interacting epitopes have been deeply analysed and characterized, providing evidence of the presence of glycan structures not found in previous MS-based analyses. The interaction of the RBD 13C-labelled
glycans with different human lectins, which are expressed in different organs and tissues that may be affected during the infection process, has also been evaluated by NMR. In particular, 15N-labelled galectins (galectins-3, -7 and -8 N-terminal), Siglecs
(Siglec-8, Siglec-10), and C-type lectins (DC-SIGN, MGL) have been employed. Complementary experiments from the glycoprotein perspective or from the lectin's point of view have permitted to disentangle the specific interacting epitopes in each case. Based
on these findings, 3D models of the interacting complexes have been proposed. © 2020 Wiley-VCH GmbH |
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Li, G, Zhou, et al |
Clinical Nutrition |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
This study aimed to evaluate the nutritional risk and therapy in severe and critical patients with COVID-19. Severe
and critical patients with COVID-19 have a high risk of malnutrition. Low BMI and protein levels were significantly associated with adverse events. Early nutritional risk screening and therapy for patients with COVID-19 are necessary. |
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|
Li, IWS, Fan, et al |
Public health |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
This study aims to investigate the filtration efficiency (FE) of home-made masks that could be used as alternatives
for community mitigation of COVID-19. The home-made masks in this study, which were made of one piece of tissue paper and two pieces of kitchen towels, layered from face to external, had an FE at 6–200 nm non-inferior to that of medical mask materials, which
had a certified FE of ≥95% at 3 μm. In the current COVID-19 pandemic with the shortage of medical masks, these home-made masks combined with an external plastic shield could be used as an alternative to medical masks for community mitigation. In addition,
one piece of tissue paper could be placed adjacent to the inner surface of a medical mask to prolong effective lifespan of the medical mask. |
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Early predictors for mechanical ventilation in COVID-19 patients |
Li, W, Lin, et al |
Therapeutic Advances in Respiratory Disease |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to identify potential predictors for invasive and non-invasive mechanical ventilation in coronavirus
disease 2019 (COVID-19) patients. Glucocorticoid, increased neutrophil and LDH were predictive indicators for IMV, whereas glucocorticoid, increased neutrophil and PCT were predictive indicators for NIMV. In addition, the above-mentioned mediators had the
most predictive meaning for mechanical ventilation when combined. |
|
Li, X, Li, et al |
Journal of psychosomatic research |
Healthcare Response | Réponse des soins de santé |
This study aims to examine the incidence of mental health symptoms and predictors of Post-Traumatic Stress Disorders
(PTSD) symptoms among the reserve medics working in Wuhan, the capital city of Hubei Province. During the stay in Wuhan, the medics experienced high levels of depression (46.7%), anxiety (35.6%) and stress symptoms (16.0%). Upon returning home, the overall
prevalence of clinically concerned PTSD symptoms was as high as 31.6%. Further analyses revealed that PTSD symptoms and its subscales were significantly associated with age, collegial relationship and mental health status during their service. |
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Individual-Level Fatality Prediction of COVID-19 Patients Using AI Methods |
Li, Y, Horowitz, et al |
Frontiers in Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We adopted a deep learning model to predict fatality of individuals tested positive given the patient's underlying
health conditions, age, sex, and other factors. As the allocation of resources toward a vulnerable patient could mean the difference between life and death, a fatality prediction model serves as a valuable tool to healthcare workers in prioritizing resources
and hospital space. The models adopted were evaluated and refined using the metrics of accuracy, specificity, and sensitivity. After data preprocessing and training, our model is able to predict whether a covid-19 confirmed patient is likely to be dead or
not, given their information and disposition. The metrics between the different models are compared. Results indicate that the deep learning model outperforms other machine learning models to solve this rare event prediction problem. |
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32830642; Case report: Disseminated strongyloidiasis in a patient with COVID-19 |
Lier, AJ, Tuan, et al |
American Journal of Tropical Medicine and Hygiene |
Clinical data| Données cliniques |
We report a case of a COVID-19 patient who developed disseminated strongyloidiasis following treatment with high-dose
corticosteroids and tocilizumab. Screening for Strongyloides infection should be pursued in individuals with COVID-19 who originate from endemic regions before initiating immunosuppressive therapy. |
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32800857; The costs of an expanded screening criteria for COVID-19: A modelling study |
Lim, JT, Dickens, et al |
International Journal of Infectious Diseases |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique Healthcare Response | Réponse des soins de santé |
We aimed to assess the cost and health outcomes of an extended screening strategy, implemented in Singapore on 07 February
2020, which maximizes case identification in the public healthcare system. In the base case analysis, an R0 of 2.5 and incubation period of 4 days, an estimated 239 (95% CI: 201–287) cases could be averted over 150 days within the hospital setting through
ESC. A corresponding $2.36 (2–2.85) million USD in costs could be averted with net cost savings of $124,000 (95% CI: −334,000 to 516,000). In the sensitivity analyses, when positive identification rates (PIR) were above 7%, regardless of R0 and incubation
period, all scenarios were cost-saving. |
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33053075; Functional development of swallowing in ICU patients with COVID-19 |
Lima, MS, Sassi, et al |
CoDAS |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
PURPOSE: to describe de functional development of swallowing in Intensive Care Unit (ICU) patients with COVID-19, who
were submitted to a swallowing intervention. |
|
Liu, R, Chen, et al |
Medical Science Monitor |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The aim of our work was to evaluate the correlation between the quantitative parameters of the peak lesion to 25% improvement
time (PIT25) and the prognosis of new COVID-19 patients by analyzing the changes of chest CT imaging. In the peak time, the most common images of CT were ground-glass opacities (94.1%), consolidation (85.3%) and reticulation (88.2%), multifocal (97.1%), center
and subpleural (54.4%), subpleural distribution (45.6%), and pleural thickening (79.4%). The PIT25 with the prognosis (r=0.53, p=0.00) was significantly relevant. PIT25 was 4.3±0.7 days for the obvious absorption group and 6.8±1.4 days for the non-obvious
absorption group. |
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Liu, X, Wang, et al |
|
Clinical data| Données cliniques |
We propose a three-stage framework, called KISEG (Key and Intermediate frame of Segmentation), to enhance performance
on serial CT image segmentation with multi-level acceleration. We first take a policy to divide frames of serial CT into two groups, key frames and intermediate frames. Then KISEG employs a main model (accurate but cumbersome) for key frame segmentation. And
third, an auxiliary model was employed for intermediate frame segmentation with incorporating the information of key frames during the fusion module. Moreover, we propose a Gaussian Kernel Dropout for data augmentation. Experiments on our dataset demonstrate
that our proposed KISEG achieves comparable accuracy with state-of-the-art methods and fewer GFLOPs, speeding up from 2.88× to 9.16×. This dataset has been made public for further research of COVID-19 for AI community, released on http://ncov-ai.big.ac.cn/download. |
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|
Liu, Y, Jiang, et al |
Sleep Medicine: X |
Healthcare Response | Réponse des soins de santé |
This study used a quasi-experimental (before and after) intervention strategy, with 151 first-line nurses from four
wards in Leishenshan hospital. A total of 140 nurses completed the DBRT sessions. First-line nurses achieved significant reductions in global sleep quality (p < 0.01), subjective sleep quality (p < 0.001), sleep latency (p < 0.01), sleep duration (p < 0.001),
sleep disturbances (p < 0.001), habitual sleep efficiency (p = 0.015), daytime dysfunction (p = 0.001), and anxiety (p = 0.001). There were no significant reductions in the use of sleeping medication (p = 0.134) and depression (p = 0.359). |
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Mental health status of healthcare workers in China for COVID-19 epidemic |
Liu, Z, Wu, et al |
Annals of Global Health |
Healthcare Response | Réponse des soins de santé |
This study aimed to understand the psychological health status of healthcare workers during the COVID-19 outbreak and
decline, and to provide a theoretical reference for the future establishment of a psychological crisis intervention system. After six weeks, the post-test GSI score; SCL-90 total score; and PST, PSDI, O-C, I-S, DEP, ANX, PHOB, PAR, PSY, and HOS scores were
significantly lower than the corresponding pretest scores (p < 0.05). The results by occupational category showed that the scores of nursing staff decreased significantly for 12 indexes and that the scores of the doctors and other hospital staff also significantly
decreased. There was a significant difference between the pretest (50.78 ± 28.18) and post-test (45.00 ± 28.49) scores for the degree of worry about the epidemic. Healthcare workers believed that the top three aspects of life affected by the epidemic were
economic problems (816 people), interpersonal communication problems (731 people), and mental health (728 people). |
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Adverse Events in Italian Nursing Homes During the COVID-19 Epidemic:
A National Survey |
Lombardo, FL, Salvi, et al |
Frontiers in Psychiatry |
Healthcare Response | Réponse des soins de santé |
The objective of our study was to report the frequency of adverse events (AEs) that occurred during the months when
SARS-CoV-2 spreading rate was at its highest in the Italian nursing homes (NHs) and to identify which conditions and attributes were most associated with the occurrence of AEs by means of multivariate regression logistic analysis. In this study, we observed
that one third of the included facilities (33.3%) reported at least one AE, with a total of 2,000 events. Overall, 29.0% of the NHs reported at least one laboratory-confirmed case of COVID-19 among residents and staff members. |
|
An Augmented Multilingual Twitter Dataset for Studying the COVID-19 Infodemic |
Lopez, ChristianE, Gallemore, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
We present an openly available dataset to facilitate researchers’ exploration of popular discourse about the COVID-19
pandemic. To facilitate access for other researchers, the English-language tweet data has been augmented by state-of-the-art Twitter sentiment and named entity recognition algorithms. The dataset and the summary files we provide allow researchers to avoid
some computationally intensive analyses, facilitating more widespread use of social media data to gain insights on issues such as (mis)information diffusion, semantic networks, sentiment, and the evolution of COVID-19 discussions. |
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The impact of social distancing policy on small and medium-sized enterprises (SMEs) in Indonesia |
Lutfi, M, Buntuang, et al |
Problems and Perspectives in Management |
Public Health response| Interventions de santé publique |
This study aims to investigate the impact of social distancing policies on small and medium-sized enterprises (SMEs)
in Indonesia. It used a quantitative method with a survey design. The result showed that social distancing policies affect SMEs during the COVID-19 pandemic. This is indicated by the decreasing income and demand for SMEs products, and even some have no income
(mean values of 2.40) due to the social distancing policies. Besides, the policy’s impact is also shown in the increasing cost of raw materials and production costs due to supply chain problems (mean values of 4.79). |
|
Lyonnais, Sebastien, Henaut, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, single SARS-CoV-2 viruses were analyze by atomic force microscopy (AFM) operating directly in a level 3 biosafety
(BSL3) facility, which appeared as a fast and powerful method to assess infectious virus morphology in its native conformation, or upon inactivation treatments, at the nanoscale level and in 3D. High resolution AFM reveals structurally intact infectious and
inactivated SARS-CoV-2 upon low concentration of formaldehyde treatment Overall, we illustrate how adapted BSL3-atomic force microscopy is a remarkable toolbox for rapid and direct virus identification and characterization. |
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|
M S, US, R, et al |
International Journal of Pervasive Computing and Communications |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Risk- and symptom-based measurements are imposed to deliver a symptom subsiding diagnosis plan. Monitoring and tracking
down the symptoms inflicted areas, social distancing and its outcomes, treatments, planning and delivery of healthy food intake, immunity improvement measures are other areas of potential guidelines to mitigate the disease. |
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Impact of COVID-19 on Stroke Caseload in a Major Hyperacute Stroke Unit |
Mag Uidhir, F, Bathula, et al |
Journal of Stroke and Cerebrovascular Diseases |
Healthcare Response | Réponse des soins de santé |
Admissions to the stroke unit of Northwick Park Hospital in London, United Kingdom (UK) were analyzed to determine
changes during the peak of COVID-19. Compared with the previous year, mean 96 patients were admitted with suspected stroke during April and May 2020 compared with mean 116 per month in non-COVID periods, ratio 0.82, P = 0.01. This reduction involved both strokes
and mimics and was unlikely to have occurred by chance. Numbers of patients thrombolysed and of patients referred for thrombectomy decreased dramatically during this time. |
|
Mahanty, C, Kumar, et al |
Quality and Quantity |
Public Health response| Interventions de santé publique |
This study aimed to evaluate the impact of COVID-19 on sexual, mental and physical health in India though a questionnaire.
Frequency of sexual intercourse, frequency of watching porn, sexual hygiene, frequency of physical activity, depression, desire for parenthood in female respondents have more significant R2 (0.903, 0.976, 0.973, 0.989, 0.985, 0.862) value respectively as compared
to male respondents. Financial anxiety, smoking and drinking habits in male respondents have more significant R2 (0.917, 0.964) value respectively as compared to female respondents. |
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Congenital Inner Ear Abnormalities and COVID-19-Related Ear Infections |
Maharaj, S, Hari, et al |
Ear Nose Throat J |
Clinical data| Données cliniques |
Case report of a 44 year-old man that was admitted to hospital after experiencing an acute onset of spontaneous vertigo
with nausea/vomiting and associated right-sided nonpulsatile tinnitus and was diagnosed with COVID-19. In our patient, the acute symptoms of vertigo and tinnitus coincided with the diagnosis of COVID-19. It is unlikely that the symptomatology was related to
the acute infection, even in the face of the underlying congenital abnormality. |
|
Mahmoud, HK, Asghar, et al |
Bioorganic chemistry |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We utilized the docking approach to examine the potential of nanosized-formazan analogues to inhibit SARS-CoV-2 3CLpro.
The results were very promising verifying these formazan analogues as a hopeful antiviral agents. |
|
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Management Trends in the Cath Lab During the COVID-19 Period, an Egyptian Survey |
Mahmoud, SED, Etriby, et al |
Current problems in cardiology |
Healthcare Response | Réponse des soins de santé |
The objectives of this study were to analyze and assess the impact of COVID 19 pandemic on the: (1) volume, type of
patients, and the different procedures performed. (2) The changes in management trends of cardiologists in the cath labs. Results find that only 63.3% of surveyed centers were well equipped to deal with COVID-19 active patients and full personal protective
equipment was worn in only 6.7% of patients. A decrease in the volume of new acute coronary syndrome (ACS) patients, ST-elevation myocardial infarction patients and primary percutaneous coronary intervention (PCI) was recorded in 80%, 83%, and 80% of the surveyed
centers respectively. Overall, there was a decrease in the volume of patients receiving elective procedures in 83.3% of cath labs. |
|
Majeed, T, Ali, et al |
Indian Journal of Surgery |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Our aim was to determine the diagnostic accuracy in terms of sensitivity and specificity of CT chest in diagnosing
and confirming COVID-19 infection in patients presenting with acute surgical and medical pathologies a UK hospital. There were 207 patients with high clinical suspicion of COVID-19. Of those 207 patients, 77 patients had CT thorax with radiographic features
consistent with COVID-19 pneumonia. However, only 40 patients had a positive RT-PCR result. CT thorax was normal in 130 patients, out of which 29 patients were found to have COVID-19 diagnosis after swab test. Sensitivity of CT scan to diagnose COVID-19 infection
was found to be 58% (95% CI; 45.48% to 69.76%) whilst specificity was 73% (95% CI; 64.99% to 80.37%) with a negative predictive value of 77.69% (95% CI; 72.17% to 82.39%). With a negative predictive value of up to 82.4%, CT thorax can play an important role
to help surgeons in their decision making for asymptomatic suspected cases of COVID-19. |
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Malekzadeh, R, Abedini, et al |
International immunopharmacology |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This multicenter, prospective, open-label, uncontrolled study aimed to assess the use of subcutaneous tocilizumab in
adult patients with severe and critical COVID-19. Tocilizumab was added to the standard care of therapy at a dose of 324 mg (<100 kg bodyweight) or 486 mg (≥100 kg bodyweight). The study endpoints were all-cause mortality rate, changes in oxygen-support level,
oxygen saturation, body temperature, respiratory rate, and laboratory variables during the study, and drug safety. Outcomes concerning three additional endpoints (oral temperature, oxygen saturation, and respiratory rate) were significantly improved as early
as three days after tocilizumab administration in both groups of subjects, more considerably in severe patients. No tocilizumab-related serious adverse event occurred in this study. |
|
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Reconfiguring and ramping-up ventilator production in the face of COVID-19: Can robots help? |
Malik, AA, Masood, et al |
Journal of Manufacturing Systems |
Public Health Priorities| Priorités de santé publique |
The study explores the rationale of human-robot teams to ramp up production of ventilators using advantages of both
the ease of integration and maintaining social distancing. The paper presents a model for faster integration of collaborative robots and design guidelines for workstations. |
|
Mandour, YM, Zlotos, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We describe a multi-stage virtual screening protocol including pharmacophore screening, molecular docking and protein-ligand
interaction fingerprints (PLIF) post-docking filtration for efficient enrichment of potent SARS-CoV-2 Mpro inhibitors. Five FDA-approved drugs showed promising binding modes. The identified compounds belong to different pharmaceutical classes, including several
protease inhibitors, antineoplastic agents and a natural flavonoid. |
|
|
Mansour, MA, Aboulmagd, et al |
RSC Advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This in-silico study provides an insight into the potential bindings between quinazoline-Schiff base conjugates and
SARS-CoV-2 proteins, including spike glycoprotein (SGp), main protease (Mpro) and RNA-dependent RNA polymerase (RdRp), to offer an opportunity to find an effective therapy. |
|
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Stroke in a feverish patient with covid-19 infection and unknown endocarditis |
Mantero, V, Rigamonti, et al |
Journal of Clinical Neurology (Korea) |
Clinical data| Données cliniques |
Case report of a 59-year-old male with a biological prosthetic aortic valve that had been placed 5 years previously.
He was admitted to the emergency department due to sudden-onset aphasia and right facial deficit. Low-grade fever over the previous 20 days and moderate dry cough were reported, and the patient had been treated with azithromycin and hydroxychloroquine. The
present case emphasizes the need for echocardiography in urgent practice to ensure the correct differential diagnosis on etiologies when deciding whether a patient with ischemic stroke should be subjected to thrombolytic therapy. |
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The burden of anxiety among people living with HIV during the COVID-19 pandemic in Pune, India |
Marbaniang, I, Sangle, et al |
BMC Public Health |
Public Health response| Interventions de santé publique |
We sought to quantify the prevalence of anxiety symptoms, and the sources of anxiety among people living with HIV (PLHIV)
in Pune, India during the COVID-19 pandemic. Among 167 PLHIV, prevalence of generalized anxiety was 25% (n = 41). PLHIV with GAD-7 score ≥ 10 had fewer remaining doses of ART than those with lower GAD-7 scores (p = 0.05). Thematic analysis indicated that concerns
were both health related and unrelated, and stated temporally. Present concerns were often also projected as future concerns. |
|
Markandeya, Verma, PK, et al |
Environ Sci Pollut Res Int |
Public health interventions*| Interventions de santé publique |
The present work aims to investigate seasonal variations in air pollution levels in Lucknow and assess the ambient
air quality of the city together with highlighting the health impacts of major pollutants like PM10, PM2.5, SO2, NO2, Pb, Ni and aerosols from 2010 to 2019 and additional analyses for the period of the COVID-19 lockdown. During the lockdown, PM2.5 levels
reduced by 65% (at Gomti Nagar), 23% (at central school), 79% (at Lalbagh) and 35% (at Talkatora), due to which, air quality index of Gomti Nagar came down to 43, well below 50 which falls in the healthy range. NO2 levels also came down. However, levels of
SO2 did not show significant reduction. |
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|
Risk Factors Associated with Increased Antibiotic Use in COVID-19
Hospitalized Patients |
Martin, AlysaJ, Pillinger, et al |
medRxiv |
Clinical data| Données cliniques |
This retrospective, multi-center, observational study sought to determine antibiotic prescribing rates and risk factors
for antibiotic prescribing in hospitalized patients in New York. A total of 208 encounters (198 patients) were included in the final analysis. Eighty-three percent of patients received at least one course of antibiotics, despite low rates of microbiologically
confirmed infection (12%). Almost one-third of patients (30%) received more than one course of antibiotics. There was a low rate of respiratory cultures obtained (32%). Risk factors identified in a univariate analysis for both antibiotic prescribing and receiving
more than one course of antibiotics were more serious illness, increased hospital length of stay, ICU admission, mechanical ventilation, and ARDS. |
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Influenza vaccination and risk of sars-cov-2 infection in a cohort of health workers |
Martínez-Baz, I, Trobajo-Sanmartín, et al |
Vaccines |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study aims to evaluate if influenza vaccination in the 2019–2020 season had any effect on the risk of SARS-CoV-2
confirmed infection in a cohort of health workers in Spain. A cohort of 11,201 health workers was highly tested by RT-qPCR and/or rapid antibody test when the infection was suspected. Later in June, 8665 of them were tested for total antibodies in serum. A
total of 890 (7.9%) health workers were laboratory-confirmed for SARS-CoV-2 infection by any type of test, while no case of influenza was detected. The adjusted odds ratio between 2019–2020 influenza vaccination and SARS-CoV-2 confirmed infection was the same
(1.07; 95% CI, 0.92–1.24) in both comparisons of positive testers with all others (cohort design) and with negative testers (test-negative design). Among symptomatic patients tested by RT-qPCR, the comparison of positive cases and negative controls showed
an adjusted odds ratio of 0.86 (95% CI, 0.68–1.08). These results suggest that influenza vaccination does not significantly modify the risk of SARS-CoV-2 infection. |
|
Massad, I, Al-Taher, et al |
Eastern Mediterranean Health Journal |
Public Health response| Interventions de santé publique |
In this study, we aimed to estimate the prevalence of quarantine-related anxiety and its socioeconomic correlates.
An online questionnaire was utilized to collect information about quarantine-related anxiety and related factors from a non-representative sample of Jordanian population (n= 5274) in March 2020 to this end. The prevalence of mild, moderate, and severe anxiety
was 21.5%, 10.9%, and 6%, respectively. Female gender (β= 0.47, 95% CI: 0.34 to 0.59) and more members of the household (β= 0.04, 95% CI: 0.00 to 0.07) were correlated with a higher degree of anxiety, while older age (β= -0.27, 95% CI: -0.33 to -0.20), having
larger social network (β= -0.17, 95% CI -0.22 to -0.13), social support (β= -0.28, 95% CI: -0.32 to -0.23), and higher income (>2000 Jordanian Dinars vs reference, β= -0.52, 95% CI: -0.71 to -0.33) were correlated with lower BAI scores. |
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|
Matsuda, EM, Santos, et al |
Brazilian Journal of Infectious Diseases |
Clinical data| Données cliniques |
Herein we report a case of SARS-CoV-2 related MIS-C observed at end of April 2020. A previously healthy 10-year-old
male child was admitted to the pediatric department with a seven-day history of fever, abdominal pain and diarrhea. On physical examination, he was afebrile, dehydrated, prostrated and with conjunctival erythema. On the following day the patient had high fever
(39.6 °C), which persisted at a lower level (37.8–38 °C) until the seventh day. |
|
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More than Just Pneumonia: Acute Pulmonary Embolism in Two Middle-Aged Patients with COVID-19 |
Mazo, J, Singh, et al |
Case Reports in Medicine |
Clinical data| Données cliniques |
In this report, we present two patients, both under the age of 40 with known risk factors for venous thromboembolism,
who presented with respiratory distress. Both patients were diagnosed with SARS-CoV-2 pneumonia and pulmonary embolism requiring management with anticoagulation. We suspect that a prothrombotic inflammatory response provoked by coronavirus disease could be
the culprit, acting as an additive effect on middle-aged patients with known risk factors for venous thromboembolism. |
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State-wise prevalence of COVID 19 in India by using machine learning approaches |
Meghana, BSK, Kakulapati, et al |
International Journal of Pharmaceutical Research |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this work, polynomial regression analysis methods employ to to forecast the number of COVID 19 corona patients.
In this, we described a decision tree, polynomial and random forest classification of disease in COVID 19 incidences modelling and forecasting in India and a predicted prevalence of high level of confidence. |
|
Covid19, 2020 - On the number of infected cases and the effective
reproduction rate |
Meilijson, Isaac |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The purpose of the current report is to propose techniques to read and interpret the pertinent data, from the point
of view of the SIR model and roughly by the equation driving new affected cases of COVID-19. The number of recovered cases is calibrated in time, and the number of infected cases is derived by a linear regression equation. Emphasis is placed on the adaptive
assessment of the effective reproduction rate R0, especially in countries with under-reported recovered cases. |
|
A cysteine protease inhibitor blocks SARS-CoV-2 infection of human
and monkey cells |
Mellott, Drake, Tseng, et al |
bioRxiv |
Therapeutics| Thérapeutique |
We confirm that a cysteine protease inhibitor (K777 a di-peptide analog ), approved by the FDA as a clinical-stage
compound, inhibits SARS-CoV-2 infection of several human and monkey cell lines with notable (nanomolar) efficacy. |
|
Meraviglia, C, Dudka, et al |
International Journal of Sociology |
Public Health response| Interventions de santé publique |
This study examines whether and how the lockdown due to the Covid-19 epidemic affected the division of household activities
between partners in a sample of dual-earner heterosexual couples in Italy. We conducted an online survey, which one partner per couple has been asked to answer (N = 934 cases, 613 of which are workers of the University of Milan). Our results show that the
division of household and care activities remains highly gendered for the more unpleasant tasks, while some others, such as cooking, are less gender sensitive. Women have still a greater burden of house chores and childcare, no matter whether they had their
income or suffered some loss, and no matter whether they or their partner worked at home or the workplace. |
|
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Miller, J, Cantor, et al |
Gastroenterology |
Clinical data| Données cliniques |
We conducted a retrospective chart review of the 44 patients who were hospitalized with a diagnosis of MIS-C at the
Children’s Hospital at Columbia University Irving Medical Center in order to examine the relationship between gastrointestinal (GI) symptoms and MIS-C. 84.1% of children presented with at least one GI symptom suggesting that GI signs and symptoms appear prominently
as presenting features of MIS-C.4,5,8 These data suggest that the vast majority of patients who develop this condition present with GI symptoms mimicking GI infection or even inflammatory bowel disease. |
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SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling |
Miorin, L, Kehrer, et al |
Proc Natl Acad Sci U S A |
Coronavirology| Coronavirologie Immunology | Immunologie |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease
2019 (COVID-19) pandemic that is a serious global health problem. Evasion of IFN-mediated antiviral signaling is a common defense strategy that pathogenic viruses use to replicate and propagate in their host. In this study, we show that SARS-CoV-2 is able
to efficiently block STAT1 and STAT2 nuclear translocation in order to impair transcriptional induction of IFN-stimulated genes (ISGs). Our results demonstrate that the viral accessory protein Orf6 exerts this anti-IFN activity. We found that SARS-CoV-2 Orf6
localizes at the nuclear pore complex (NPC) and directly interacts with Nup98-Rae1 via its C-terminal domain to impair docking of cargo-receptor (karyopherin/importin) complex and disrupt nuclear import. In addition, we show that a methionine-to-arginine substitution
at residue 58 impairs Orf6 binding to the Nup98-Rae1 complex and abolishes its IFN antagonistic function. All together our data unravel a mechanism of viral antagonism in which a virus hijacks the Nup98-Rae1 complex to overcome the antiviral action of IFN. |
|
Mittal, R, Meneveau, et al |
Physics of Fluids |
Modelling/ prediction| Modélisation/prédiction Transmission |
A mathematical model for estimating the risk of airborne transmission of a respiratory infection such as COVID-19 is
presented. The model employs basic concepts from fluid dynamics and incorporates the known scope of factors involved in the airborne transmission of such diseases. The model is used to assess the protection from transmission afforded by face coverings made
from a variety of fabrics. The reduction in the transmission risk associated with increased physical distance between the host and susceptible is also quantified by coupling the model with available and new large eddy simulation data on scalar dispersion in
canonical flows. Finally, the effect of the level of physical activity (or exercise intensity) of the host and the susceptible in enhancing the transmission risk is also assessed. |
|
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Relationship between weather variables and new daily covid-19 cases in Dhaka, Bangladesh |
Mofijur, M, Rizwanul Fattah, et al |
Sustainability (Switzerland) |
Epidemiology| Épidémiologie |
The present study investigated the relationship between the transmission of COVID-19 infections and climate indicators
in Dhaka, Bangladesh, using coronavirus infections data available from the Institute of Epidemiology, Disease Control and Research (IEDCR), Bangladesh. The Spearman rank correlation test was carried out to study the association of seven climate indicators,
including humidity, air quality, minimum temperature, precipitation, maximum temperature, mean temperature, and wind speed with the COVID-19 outbreak in Dhaka, Bangladesh. The study found that, among the seven indicators, only two indicators (minimum temperature
and average temperature) had a significant relationship with new COVID-19 cases. The study also found that air quality index (AQI) had a strong negative correlation with cumulative cases of COVID-19 in Dhaka city. |
|
The papain-like protease of coronaviruses cleaves ULK1 to disrupt
host autophagy |
Mohamud, Yasir, Chao Xue, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Our study identified a new mechanism by which PLpro of betacoronaviruses induces viral pathogenesis by targeting cellular
autophagic pathway. |
|
Möhring, K, Naumann, et al |
European Societies |
Public Health response| Interventions de santé publique |
This paper provides a timely evaluation of whether the main COVID-19 lockdown policies–remote work, short-time work
and closure of schools and childcare–have an immediate effect on the German population in terms of changes in satisfaction with work and family life. We conclude that while the lockdown circumstances generally have a negative effect on the satisfaction with
work and family of individuals in Germany, effects differ between childless persons, mothers, and fathers with the latter being least negatively affected. |
|
|
Moyles, IainR, Heffernan, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique Economics | Économie |
A mathematical model of COVID-19 is presented where the decision to increase or decrease social distancing is modelled
dynamically as a function of the measured active and total cases as well as the perceived cost of isolating. We observe that minimum costs are not always associated with increased spending and increased vigilance which is due to the desire for people to not
distance and the fatigue they experience when they do. We demonstrate that an increased in the number of lock-downs, each of shorter duration can lead to minimal costs. Our results are compared to case data in Ontario, Canada from March to August 2020. |
|
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Müller, JanisA, Groß, et al |
Research Square prepub |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
Here, we (i) defined ACE2 and TMPRSS2 expression patterns in human pancreatic endocrine and exocrine cell types, (ii)
employed human pancreatic islet cultures to demonstrate susceptibility to SARS-CoV-2 infection and to viral replication in β-cells, (iii) showed that SARS-CoV-2 attenuates glucose-stimulated insulin secretion, and (iv) tested remdesivir as eventually effective
to prevent β-cell failure. In addition, we (v) visualized viral particles replicating in endocrine pancreatic cells and define their subcellular localization patterns via transmission electron microscopy, and finally (vi) present examples of cell type specific
pancreatic infection patterns of COVID-19 deceased patients. Overall, our data demonstrate that SARS-CoV-2 can infect both the exocrine and endocrine compartments of the pancreas and can perturb β-cell integrity, which might lead to an increased risk for diabetes. |
|
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Muntean, PE, Mihai, et al |
Archives of the Balkan Medical Union |
Clinical data| Données cliniques |
A 36-year-old man, chronic smoker, treated successfully, complains of seven days of persistent muscle pain, sore throat,
cough with intermittent mucopurulent expectoration, right-sided chest pain, chills, high-grade fever, difficulty of breathing and weight loss. He was visited at home by his family physician and assessed with chromatographic immunoassay for the qualitative
detection of IgG & IgM antibody of COVID-19. The rapid test was non-reactive. Nasopharyngeal and oropharyngeal swabs tested positive for SARS-CoV-2 RT-PCR. |
|
|
Nabeel-Shah, Syed, Lee, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Starting from a functional proteomics workflow, we initially catalogued the protein-protein interactions of 21 SARS-CoV-2
proteins in HEK293 cells, finding that the stress granule resident proteins G3BP1 and G3BP2 co-purify with N with high specificity. We demonstrate that N protein expression of in human cells sequesters G3BP1 and G3BP2 through its physical interaction with
these proteins, attenuating stress granule (SG) formation. The ectopic expression of G3BP1 in N-expressing cells was sufficient to reverse this phenotype. Since N is an RNA-binding protein, we performed iCLIP- sequencing experiments in cells, with or without
exposure to oxidative stress, to identify the host RNAs targeted by N. Our results indicate that SARS-CoV-2 N protein binds directly to thousands of host mRNAs under both conditions. Like the G3BPs stress granule proteins, N was found to predominantly bind
its target mRNAs in their 3UTRs. RNA sequencing experiments indicated that expression of N results in wide-spread gene expression changes in both unstressed and oxidatively stressed cells. We suggest that N regulates host gene expression by both attenuating
stress granules and binding directly to target mRNAs. |
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Physical therapy for a patient with SARS-COV-2 infection: A case study |
Narita, J, Akiyama, et al |
Rigakuryoho Kagaku |
Clinical data| Données cliniques |
This paper reports a patient with a worsened breathing condition due to SARS-CoV-2 infection, treated with extracorporeal
membrane oxygenation (ECMO) for life-saving support and physical therapy for disuse syndrome prevention. |
|
Negrini, F, Ferrario, et al |
Archives of Physical Medicine and Rehabilitation |
Clinical data| Données cliniques |
Results indicate that some patients with COVID-19 might also benefit from neuropsychological rehabilitation, given
their possible global cognitive decay. The link between neuropsychological functioning and the length of stay in the ICU suggests that neurocognitive rehabilitative treatments should be directed explicitly toward patients who treated in the ICU, rather than
toward every patient who experienced acute respiratory distress syndrome owing to COVID-19. |
|
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Newcomb, Kenneth, Smith, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We present the development of a data-driven iterative modelling tool based on publicly-available data and an extended
SEIR model for forecasting SARS-CoV-2 at the county level in the United States, and demonstrate, using data from the state of Florida, how this tool can be used to explore the outcomes of the social measures proposed for containing the course of the pandemic
as a result of easing the initially imposed lockdown in the state. We provide comprehensive results showing the use of the locally identified models for accessing the impacts and societal tradeoffs of using specific strategies involving movement restriction,
social distancing and mass testing, and conclude that while it is absolutely vital to continue with these measures over the near-term and likely to the end of March 2021 in all counties for containing the ongoing pandemic before less socially-disruptive vaccination
strategies come into play, it could be possible to lift the more disruptive movement restriction/social distancing measures by end of December 2020 if these are accompanied by widespread testing and contact tracing. Our findings further show that such intensified
social interventions could potentially also bring about the control of the epidemic in low and some medium incidence counties first, supporting the development and deployment of a geographically-phased approach to reopening the economy of Florida. |
|
|
Spike glycoprotein and host cell determinants of SARS-CoV-2 entry
and cytopathic effects |
Nguyen, HanhT, Zhang, et al |
bioRxiv |
Coronavirology| Coronavirologie |
The SARS-CoV-2 spike (S) glycoprotein trimer mediates virus entry into host cells and cytopathic effects. We studied
the contribution of several S glycoprotein features to these functions, focusing on those that differ among related coronaviruses. Acquisition of the furin cleavage site by the SARS-CoV-2 S glycoprotein decreased virus stability and infectivity, but greatly
enhanced the ability to form lethal syncytia. Notably, the D614G change found in globally predominant SARS-CoV-2 strains restored infectivity, modestly enhanced responsiveness to the ACE2 receptor and susceptibility to neutralizing sera, and tightened association
of the S1 subunit with the trimer. Apparently, two unique features of the SARS-CoV-2 S glycoprotein, the furin cleavage site and D614G, have evolved to balance virus infectivity, stability, cytopathicity and antibody vulnerability. Although the endodomain
(cytoplasmic tail) of the S2 subunit was not absolutely required for virus entry or syncytium formation, alteration of palmitoylated cysteine residues in the cytoplasmic tail decreased the efficiency of these processes. As proteolytic cleavage contributes
to the activation of the SARS-CoV-2 S glycoprotein, we evaluated the ability of protease inhibitors to suppress S glycoprotein function. Matrix metalloprotease inhibitors suppressed S-mediated cell-cell fusion, but not virus entry. Synergy between inhibitors
of matrix metalloproteases and TMPRSS2 suggest that both proteases can activate the S glycoprotein during the process of syncytium formation. |
|
Niu, X, Li, et al |
Frontiers in Immunology |
Immunology | Immunologie |
We applied a novel dimer avoidance multiplexed polymerase chain reaction next-generation sequencing assay to analyze
T (TCR) and B cell receptor (BCR) repertoires. Surprisingly, TCR repertoires were markedly diminished during the early onset of severe disease but recovered during the convalescent stage. Panoramic concurrent assessment of BCR repertoires demonstrated isotype
switching and a transient but dramatic early IgA expansion. Dominant B cell clonal expansion with decreased diversity occurred following recovery from infection. |
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Air-pollutant mass concentration changes during COVID-19 pandemic in Shanghai, China |
Niu, Z, Hu, et al |
Air Quality, Atmosphere and Health |
Public health interventions*| Interventions de santé publique |
This study aims to investigate air pollutant mass concentration changes during the lockdown in Shanghai. The data was
classified in three periods: P1 (pre-lockdown: 10 days before the Spring Festival), P2 (the first 10 days after lockdown: during the Spring Festival celebration), and P3 (the second 10 days after lockdown: after the Spring Festival). The results indicate that
the Spring Festival holiday in 2019 resulted in a reduction in energy consumption, which led to a decrease in PM2.5 (26.4%) and NO2 (43.41%) mass concentration, but an increase in ozone mass concentration (31.39%) in P2 compared with P1. The integrated effect
of the Spring Festival holiday and lockdown in 2020 resulted in a decrease in PM2.5 (36.5%) and NO2 (51.9%) mass concentrations, but an increase in ozone mass concentration (43.8%) in P2 compared with P1. After the Spring Festival, the mass concentrations
of PM2.5, SO2, and NO2 increased by 74.41%, 5.52%, and 53.28%, respectively in P3 compared with P2 in 2019. However, PM2.5 and SO2 concentrations in 2020 continued to decrease, by 14.74% and 4.61%, respectively, while NO2 mass concentration increased by 7.82%
in P3 compared with P2. We also found that PM2.5 mass concentration is susceptible to regional transmission from the surrounding cities. PM2.5 and other gaseous pollutants show different correlations in different periods, while NO2 and O3 always show a strong
negative correlation. The principal components before the Spring Festival in 2019 were O3 and NO2, and after the Spring Festival, they were PM2.5 and CO, while the principal components before the lockdown in 2020 were PM2.5 and CO, and during lockdown they
were O3 and NO2. |
|
Nørgård, BM, Nielsen, et al |
Br J Clin Pharmacol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
In the Danish population, we examined whether patients treated with thiopurines, methotrexate, systemic corticosteroids,
anti‐TNF‐α agents, anti‐interleukin therapeutic agents, selective immunosuppressive agents, and cyclosporine/tacrolimus had an increased risk of hospitalization for COVID‐ 19. Patients treated with systemic corticosteroids and cyclosporine/tacrolimus had a
significantly increased risk of being hospitalized for COVID‐19. Our study does not uncover whether the increased risk is related to the drug itself, the underlying condition for which the patient is treated, or other factors. |
|
|
Norton, EJ, Georgiou, et al |
J Public Health (Oxf) |
Healthcare Response | Réponse des soins de santé |
Participants reported that they received insufficient PPE information (43%) and IPC training (56%). Significantly,
fewer participants identifying as women or BAME/mixed ethnicity reported receiving sufficient PPE information, compared with those identifying as men and White British/White Other, respectively. COVID-19-related anxiety was significantly higher in those without
sufficient reported PPE or IPC training, in women compared with men, and in FiY1 doctors compared with medical students. |
|
|
Ojeda, Diego, Gonzalez Lopez Ledesma, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
We report the emergency development and application of a robust serologic test to evaluate acute and convalescent antibody
responses to SARS-CoV-2 in Argentina. Analysis of antibody levels and longitudinal studies of symptomatic and asymptomatic SARS-CoV-2 infections in over one thousand patient samples provided insightful information about IgM and IgG seroconversion time and
kinetics, and IgM waning profiles. At least 35% of patients showed seroconversion within 7 days, and 95% within 45 days of symptoms onset, with simultaneous or close sequential IgM and IgG detection. |
|
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Omae, Yuto, Toyotani, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
As of 2020, COVID-19 is spreading in the world. In Japan, the Ministry of Health, Labor and Welfare developed COVID-19
Contact-Confirming Application (COCOA). The researches to examine the effect of COCOA are still not sufficient. We develop a mathematical model to examine the effect of COCOA and show examined result. |
|
|
Ooi, MWX, Rajai, et al |
European Journal of Radiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objectives: To define the prevalence of pulmonary thromboembolic (PTE) disease diagnosed on CT pulmonary angiography
(CTPA) in COVID-19 patients. To assess distribution of PTE and to evaluate for association between severity of COVID-19 disease, D-dimer values and incidence of PTE. A total of 974 patients presented across five hospital sites with COVID-19 infection. Eighty-four
(n = 84) COVID-19 patients underwent CTPA. Of these, 38 % (32/84) had PTE. PTE was seen in small vessels in 75 % (24/32) and in lungs demonstrating COVID-19 changes in 72 % (23/32). 84 % (27/32) of PTE positive patients had disease severity of moderate or
higher score (p = 0.005). D-dimer values were significantly higher (p ≤ 0.001) in PTE patients, median value in PTE group was 6441mcg/L (range 219-90925). A D-dimer cut off value of 2247mcg/L provides sensitivity of 0.72 and specificity of 0.74. |
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O'Reilly, GM, Mitchell, et al |
EMA - Emergency Medicine Australasia |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of the present study was to describe the epidemiology and clinical features of patients presenting to the ED
with suspected and confirmed COVID-19. In the period 1 July to 31 July 2020, there were 30 378 presentations to the participating EDs and 2917 (9.6%; 95% confidence interval 9.3–9.9) underwent testing for SARS-CoV-2. Of these, 50 (2%) patients returned a positive
result. Among positive cases, two (4%) received mechanical ventilation during their hospital admission compared to 45 (2%) of the SARS-CoV-2 negative patients (odds ratio 1.7, 95% confidence interval 0.4–7.3; P = 0.47). Two (4%) SARS-CoV-2 positive patients
died in hospital compared to 46 (2%) of the SARS-CoV-2 negative patients (odds ratio 1.7, 95% confidence interval 0.4–7.1; P = 0.49). Strong clinical predictors of a positive SARS-CoV-2 result included self-reported fever, non-smoking status, bilateral infiltrates
on chest X-ray and absence of a leucocytosis on first ED blood tests (P < 0.05). |
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Orosa, JA, Nematchoua, et al |
Applied Sciences (Switzerland) |
Public health interventions*| Interventions de santé publique |
The present paper aims to show a mathematical understanding of the effect of ventilation rate over building energy
consumption. Moreover, as a case study to show this methodology, a proposal was analyzed of modifying the teaching period to reach a maximum increase of air changes in school buildings, to allow adherence to the COVID-19 pandemic requirements in the Galicia
region, with lower energy consumption. the main results showed a reduction of energy consumption at a higher ventilation rate in the summer season. As a consequence, the necessity of modifying teachings periods, as an adequate procedure to prevent more COVID
infections, is concluded. |
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Paganini, N, Adinata, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
This participatory research examines local small-scale farmers’ challenges as farmers but also as consumers and their
coping strategies during the month of April and one week in June 2020. A common observation across regions is that the measures imposed in response to COVID-19 highlighted and partly exacerbated existing socio-economic inequalities among food system actors.
Strict lockdowns in Cape Town, South Africa, and Masvingo, Zimbabwe, significantly restricted the production capacity of small-scale farmers in the informal economy and created more food insecurity for them. In Maputo, Mozambique, and Toraja and Java, Indonesia,
local food systems continued to operate and were even strengthened by higher social capital and adaptive capacities. |
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|
Palacios, R, Patiño, et al |
Trials |
RCT |
This is a Phase III, randomized, multicenter, endpoint driven, double-blind, placebo-controlled clinical trial to assess
the efficacy and safety of the adsorbed vaccine COVID-19 (inactivated) produced by Sinovac. (a protocol) |
|
|
Palladino, F, Merolla, et al |
Neurol Sci |
Healthcare Response | Réponse des soins de santé |
We investigate prevalence of admission for seizures at our emergency department (ED), during Italian lockdown, comparing
with that of the same period of the previous year (2019), and the relationship with some lifestyle changes. Fifty-seven patients were included. Considering only paediatric medical emergencies, the prevalence of accesses for seizures was 2.6% (CI 95% 0.020–0.034),
while the incidence was 0.94% (CI 95% 0.006–0.0149). There was a statistically significant difference with prevalence of previous years, χ2 102.21 (p = 0.0001). We also reported a difference in daily screen time (DST) (p = 0.001) and total sleep time (TST)
(p = 0.045), in all population, between period pre- and during lockdown. A negative correlation between DST and seizures latency (Spearman’s ρ -0.426, p = 0.038) was found. In the two groups, the results were partially overlapping. |
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Changes in Sexuality and Quality of Couple Relationship During the COVID-19 Lockdown |
Panzeri, M, Ferrucci, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
The present preliminary research aimed to understand if the Italian population’s sexuality has changed, and if so,
how it had changed since the spread of COVID-19, and which variables were influencing couples’ relationship quality during the COVID-19 lockdown. Of the 124 respondents who completed the online survey, 73% were females. Despite the pandemic’s psychological
consequences, when asked directly, most couples responded that they did not perceive any differences in their sexuality. However, some female participants did report a decrease in pleasure, satisfaction, desire, and arousal. The main reasons behind the changes
in sexuality in women, therefore, appear to be worry, lack of privacy, and stress. |
|
Park, HH, Park, et al |
Advanced Science |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Herein, it is reported that DNase-I-coated melanin-like nanospheres (DNase-I pMNSs) mitigate sepsis-associated NETosis
dysregulation, thereby preventing further progression of the disease. Recombinant DNase-I and poly(ethylene glycol) (PEG) are used as coatings to promote the lengthy circulation and dissolution of NET structure. The data indicate that the application of bioinspired
DNase-I pMNSs reduce neutrophil counts and NETosis-related factors in the plasma of SARS-CoV-2 sepsis patients, alleviates systemic inflammation, and attenuates mortality in a septic mouse model. Altogether, the findings suggest that these nanoparticles have
potential applications in the treatment of SARS-CoV-2-related illnesses and other beta-CoV-related diseases. |
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Mental Health Through the COVID-19 Quarantine: A Growth Curve Analysis on Italian Young Adults |
Parola, A, Rossi, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
This study aimed to assess and monitor Italian young adults’ mental health status during the first 4 weeks of lockdown
through the use of a longitudinal panel design. The results showed an increase in anxiety/depression, withdrawal, somatic complaints, aggressive behavior, rule-breaking behavior, and internalizing and externalizing problems and a decrease in intrusive behavior
and personal strengths. |
|
Parsons Leigh, J, Fiest, et al |
PLoS One |
Public Health response| Interventions de santé publique |
We assessed self-reported public perceptions related to COVID-19 including, beliefs (e.g., severity, concerns, health),
knowledge (e.g., transmission, information sources), and behaviors (e.g., physical distancing) to understand perspectives in Canada and to inform future public health initiatives. We collected 1,996 eligible questionnaires between April 26th and May 1st, 2020.
One-fifth (20%) of respondents knew someone diagnosed with COVID-19, but few had tested positive themselves (0.6%). Negative impacts of pandemic conditions were evidenced in several areas, including concerns about healthcare (e.g. sufficient equipment, 52%),
pandemic stress (45%), and worsening social (49%) and mental/emotional (39%) health. Most respondents (88%) felt they had good to excellent knowledge of virus transmission, and predominantly accessed (74%) and trusted (60%) Canadian news television, newspapers/magazines,
or non-government news websites for COVID-19 information. We found high compliance with distancing measures (80% reported self-isolating or always physical distancing). We identified associations between region and self-reported beliefs, knowledge, and behaviors
related to COVID-19. |
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33034578; COVID-19 hastasının nadir bir prezentasyonu: Kardiyak tamponat |
Parsova, KE, Pay, et al |
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir |
Clinical data| Données cliniques |
A 58-year-old female had been hospitalized 2 weeks prior to the currently described presentation due to atypical pneumonia.
A nasopharyngeal swab specimen was positive for COVID-19. The hospitalization was uncomplicated and she was discharged after a week. She presented at our emergency department with symptoms of shortness of breath and swelling in both legs. A bedside transthoracic
echocardiography showed globally depressed left ventricular contraction with an ejection fraction of 30% and there was significant pericardial effusion, which surrounded the entire heart and restricted diastolic filling. The patient was admitted to the coronary
intensive care unit with the diagnosis of pericardial tamponade. Bedside pericardiocentesis was performed and serohemorrhagic fluid was drained. |
|
Patil, N, Ingole, et al |
International Journal of Performability Engineering |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this study, we have proposed a model to identify pulmonary diseases such as COVID-19, pneumonia, and tuberculosis
from X-ray images. Application of deep convolutional neural networks coupled with radiological imaging can be beneficial for the accurate diagnosis of these diseases, and it can also be assistive to overcome the problem of shortage of healthcare experts in
remote villages. |
|
|
Pendyala, B, Patras, et al |
Frontiers in Microbiology |
Coronavirology| Coronavirologie Public Health Priorities| Priorités de santé publique |
In this study, we developed a pyrimidine dinucleotide frequency based genomic model to predict the sensitivity of select
enveloped and non-enveloped viruses to UV-C treatments in order to identify potential SARS-CoV-2 and human norovirus surrogates. The predicted UV-C sensitivity (D90 – dose for 90% inactivation) for SARS-CoV-2 and MERS-CoV was found to be 21.5 and 28 J/m2,
respectively, suggesting that coronaviruses are highly sensitive to UV-C light compared to other ssRNA viruses. This study provides useful insights for the identification of potential non-pathogenic (to humans) surrogates to understand inactivation kinetics
and their use in experimental validation of UV-C disinfection systems. |
|
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Pandemic Dreams: Network Analysis of Dream Content During the COVID-19 Lockdown |
Pesonen, AK, Lipsanen, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
Over the course of 1 week, 4,275 respondents (mean age 43, SD = 14 years) assessed their sleep, and 811 reported their
dream content. Overall, respondents slept substantially more (54.2%) but reported an average increase of awakenings (28.6%) and nightmares (26%) from the pre-pandemic situation. |
|
Registry of Arterial and Venous Thromboembolic Complications in Patients With COVID-19 |
Piazza, G, Campia, et al |
Journal of the American College of Cardiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We assess the frequency of arterial and venous thromboembolic disease, risk factors, prevention and management patterns,
and outcomes in patients with COVID-19. We analyzed a retrospective cohort of 1,114 patients with COVID-19 diagnosed through our Mass General Brigham integrated health network. |
|
Platero, RL, López-Sáez, et al |
Journal of Children's Services |
Public Health response| Interventions de santé publique |
The purpose of this study is to examine the situation of lesbians, gays, bisexuals, transgender, queer and asexual
(LGBTQA+) youth in Spain, pre-examining the links between the people they live with, their support networks and their perception of being a burden. This study’s data highlight the connections between places of cohabitation, support and vulnerability in a crisis
situation. |
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Plotnikow, GA, Matesa, et al |
Revista Brasileira de terapia intensiva |
Clinical data| Données cliniques |
The objective of this case series study is to describe the clinical characteristics of patients with confirmed coronavirus
disease (COVID-19) admitted to different intensive care units in Argentina for mechanical ventilation. At the end of the study, 29 patients died, 8 were discharged, and 10 remained hospitalized. Patients with COVID-19 and on mechanical ventilation in this
series presented clinical variables similar to those described to date in other international reports. Our findings provide data that may predict outcomes. |
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Prado-Gascó, V, Gómez-Domínguez, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
The aim of this study was to analyze the perception of COVID-19 and the psychosocial risks of non-university teachers
comparing Spain and Mexico during the state of alarm caused by COVID-19. Data analysis suggests that inequity is the most important risk, followed by work overload. |
|
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Prentiss, Mara, Chu, et al |
medRxiv |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
We study transmission of COVID-19 using five well-documented case studies : a Washington state church choir, a Korean
call center, a Korean exercise class, and two different Chinese bus trips. An estimate of N 0 , the characteristic number of COVID-19 virions needed to induce infection in each case, is found using a simple physical model of airborne transmission. We find
that the N 0 values are similar for five COVID-19 superspreading cases (~300-2,000 viral copies) and of the same order as influenza A. |
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Probst, T, Humer, et al |
Frontiers in Psychology |
Healthcare Response | Réponse des soins de santé |
This study investigated stress-level, degree of job-related anxiety, and fear of coronavirus disease (COVID-19) infection
in psychotherapists in the early weeks of the COVID-19 lockdown in Austria. |
|
|
Probst, TM, Lee, et al |
Journal of Applied Psychology |
Public Health response| Interventions de santé publique Economics | Économie |
The purpose of this study was to examine whether the economic stressors of perceived job insecurity and perceived financial
insecurity are related to employee self-reports of enacting recommended preventative health behaviors for Americans. We found that both job insecurity and financial insecurity were negatively related to the enactment of the CDC-recommended guidelines. However,
the state-level variables acted as cross-level moderators, such that the negative relationship between job insecurity and compliance with the CDC guidelines was attenuated within states that have a more robust unemployment system. |
|
|
Procopio, G, Cancelliere, et al |
Therapeutic Advances in Respiratory Disease |
Clinical data| Données cliniques |
Herein we describe our experience of five patients with COVID-19, who were treated with high-flow nasal cannula (HFNC)
after failure of CPAP or NIV, and discuss the role of HFNC in COVID-19 patients. Our findings suggest that HFNC can be used successfully in selected patients with COVID-19-related ARDS. |
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Pulido, L, Solís-Aramayo, et al |
Medicina |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This is a retrospective and observational study of patients with virological confirmation of coronavirus treated during
the months of March to May in a private third-level university hospital in Buenos Aires. |
|
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Underdetection of COVID-19 cases in France in the exit phase following
lockdown |
Pullano, Giulia, Di Domenico, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
20,777 virologically-confirmed cases were notified in mainland France from May 13, 2020 to June 28. Accounting for
missing data, positive tests before symptom onset, and the delay from symptom onset to test, this corresponds to 14,061 cases, a likely underestimation of the real number. Using age-stratified transmission models parameterized to behavioral data and calibrated
to regional hospital admissions, we estimated that 103,907 COVID-19 symptomatic cases occurred, suggesting that 9 out of 10 cases with symptoms were not ascertained. |
|
Quisi, A, Alıcı, et al |
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir |
Clinical data| Données cliniques |
The aim of this study was to evaluate the relationship between the CHA2DS2-VASc score and in-hospital mortality in
patients with COVID-19, regardless of AFib. The CHA2DS2-VASc score was significantly higher in non-survivor COVID-19 patients than in survivor COVID-19 patients (p<0.001). The CHA2DS2-VASc score predicted in-hospital mortality in patients with COVID-19, regardless
of AFib. |
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Ramachandra, C, Sugoor, et al |
Indian Journal of Surgical Oncology |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We report cancer surgery outcomes taking into account the acuity of the COVID-19 situation. A prospectively maintained
database of the Department of Surgical Oncology was analysed from 1st May to 30th June, 2020, to evaluate the perioperative outcomes, morbidity and mortality following major surgical procedures. A total of 359, preoperatively, tested negative for COVID-19
underwent surgery. Postoperatively, repeat COVID 19 testing in 2 suspected patients were negative. Our study showed that after screening, triaging and prioritisation, asymptomatic cases may undergo cancer surgeries without increased morbidity during COVID-19
pandemic. |
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|
Ramakrishna, JM, Libertin, et al |
Rom J Intern Med |
Clinical data| Données cliniques |
We present a case of an encephalopathic patient infected with SARS-CoV-2 with no pulmonary symptoms. We propose a three-tier
risk stratification for CNS COVID-19 aiming to help clinicians to decide which patients should undergo CSF analysis. |
|
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Virological and Serological Discordant Profiles in COVID-19 Pneumonia: Two Atypical Clinical Cases |
Ranzenigo, M, Pastori, et al |
Frontiers in Immunology |
Clinical data| Données cliniques |
We describe two moderate coronavirus disease 2019 (COVID-19) patients with WHO score 4/5 at the time of hospitalization,
pneumonia, and oxygen saturation <94% and with a strong discrepancy between viral RNA and antibodies to SARS-CoV-2. One patient was positive for viral RNA but completely negative for binding and neutralizing antibodies, whereas the second patient was negative
for viral RNA but with high levels of both neutralizing and binding antibodies. |
|
Virtual WIL clinics in medicine: Overcoming the COVID-19 challenge |
Rasalam, R, Bandaranaike, et al |
International Journal of Work-Integrated Learning |
Healthcare Response | Réponse des soins de santé |
This paper aims to demonstrate how virtual WIL clinics (virtual simulated general practice clinics), provide an authentic
clinical experience and to ascertain whether these virtual clinics allow the practice of generic WIL competencies. The clinics provide students with WIL experience without the face-to-face contact of a physical clinic via telehealth. Students surveyed (N=66)
expressed a high level of motivation to engage, reflect and learn through this medium. The survey also highlighted some possible areas of improvement. |
|
Rastogi, A, Hiteshi, et al |
International Journal of Diabetes in Developing Countries |
Public Health response| Interventions de santé publique |
We studied the physical activity and glycemic control during lockdown in comparison to pre-lockdown parameters in individuals
with long-standing type 2 diabetes. A total of 422 out of 750 participants (nest) responded. The median (IQR) for age was 58 (52 to 64) years, duration of diabetes 11 (6 to 16) years. The improvement of glycemic control was observed in either gender and independent
of the presence of foot complications or increase in physical activity. |
|
|
Rauch, Susanne, Roth, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins Animal model | Modèle animal |
Here, we show preclinical data for our clinical candidate CVnCoV, a lipid nanoparticle (LNP) encapsulated non-modified
mRNA vaccine that encodes the full length, pre-fusion stabilised SARS-CoV-2 Spike (S) protein. Immunisation with CVnCoV induced strong humoral responses with high titres of virus neutralizing antibodies in mice and hamsters and robust CD4+ and CD8+ T cell
responses in mice. Most importantly, vaccination with CVnCoV fully protected hamster lungs from challenge with wild type SARS-CoV-2. |
|
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Social work during the covid-19 crisis: Responding to urgent social needs |
Redondo-Sama, G, Matulic, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
This study analyzes the immediate responses in social work to vulnerable groups in the first 15 days of the pandemic
in Barcelona, one of the most affected areas worldwide by COVID-19. The sample for this qualitative study includes 23 semi-structured interviews with social workers from different fields of intervention, from general approaches (primary care) to specific ones
(health, ageing, homeless, and justice). |
|
Positive Postmortem Test for SARS-CoV-2 Following Embalming in Confirmed COVID-19 Autopsy |
Rodic, N, Tahir, et al |
Am J Clin Pathol |
Clinical data| Données cliniques |
We report a case of an 82-year-old man who, at 1 to 2 days antemortem, developed the clinical symptoms of cough, fever,
and low oxygenation while in a nursing home facility. Before onset, the patient was hospitalized approximately 2 months antemortem for attempted left lower leg arteriograms. A lung-only private medical autopsy with coronavirus disease 2019 (COVID-19) precautions
was performed following embalming on day 1 postmortem; the interval from embalming to autopsy was 1 day. |
|
Rodriguez, JorgeH, Gupta, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
We have uniquely identified dominant molecular-level interactions, some attractive and some repulsive, between the
receptor binding domain of SARS-CoV-1 spike proteins (S-RBD) and hACE2. Two hACE2 fragments which include residues (GLU37, ASP38, TYR41, GLN42) and (GLU329, LYS353, GLY354), respectively, as well as three S-RBD fragments which include residues (TYR436), (ARG426)
and (THR487, GLY488, TYR491), respectively, have been identified as primary attractors at the hACE2...S-RBD interface. |
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Acute mesenteric thrombosis in two patients with COVID-19. Two cases report and literature review |
Rodriguez-Nakamura, R, Gonzalez-Calatayud, et al |
International Journal of Surgery Case Reports |
Clinical data| Données cliniques |
We report 2 cases of COVID-19 with acute mesenteric thrombosis. The first patient is 45 years-old who has been exposed
to SARS CoV-2; and the second one is 42 years-old and has comorbidities. Despite the fact that knowledge of the disease is rapidly advancing, all available treatments are still nonspecific to SARS-CoV-2 and the optimal management of COVID-19 remains unclear. |
|
Rolnik, DL, Korman, et al |
Women and Birth |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigate the rate of positive tests among pregnant women in Melbourne, Australia. We performed a cross-sectional
prevalence study at three maternity hospitals. SARS-CoV-2 testing was performed in 350 women, of whom 19 had symptoms of possible COVID-19. In a two-week period of low disease prevalence, the rate of asymptomatic coronavirus infection among pregnant women
in Australia during the study period was negligible, reflecting low levels of community transmission. |
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Transcatheter aortic valve replacement during the COVID-19 pandemic—A Dutch single-center analysis |
Rooijakkers, MJP, Li, et al |
Journal of cardiac surgery |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study is to evaluate the safety and feasibility of patients undergoing TAVR during the COVID‐19 pandemic
in our center, with specific emphasis on COVID‐19 related outcomes. A total of 71 patients have undergone TAVR during the study period. After TAVR, 30% involved admission to the ICU, and 94% were ultimately discharged to the cardiac care unit on the same day.
Two patients (3%) had confirmed COVID‐19 a few days after TAVR, and both died of COVID‐19 pneumonia within 2 weeks after hospital discharge. |
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Factors affecting COVID-19 infected and death rates inform lockdown-related policymaking |
Roy, S, Ghosh, et al |
PLoS One |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
We use datasets on US states to create an integrated dataset of potential factors leading to the pandemic spread; and
carry out regression analysis to pinpoint the key pre-lockdown factors that affect post-lockdown infection and mortality. Population density, testing numbers and airport traffic emerge as the most discriminatory factors, followed by higher age groups (above
40 and specifically 60+). Post-lockdown infected and death rates are highly influenced by their pre-lockdown counterparts, followed by population density and airport traffic. Mortality rate seems to be driven by individual physiology, preexisting condition,
age etc., rather than gender, healthcare facility or ethnic predisposition. |
|
Ruiz Estrada, Mario Arturo |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Economics | Économie |
This paper presents a new methodology for studying trade closedness from a global pandemic such as COVID-19. The mission
of this model is to offer policy-makers and researchers' a new analytical tool to study the impact of COVID-19 in world trade from a new perspective. We propose a new model entitled "The Global Trade Closedness Model (GTC-Model)," a simple and flexible model. |
|
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Use of exhaled breath condensate (EBC) in the diagnosis of SARS-COV-2 (COVID-19) |
Ryan, DJ, Toomey, et al |
Thorax |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
False negatives from nasopharyngeal swabs (NPS) using reverse transcriptase PCR (RT-PCR) in SARS-CoV-2 are high. Exhaled
breath condensate (EBC) contains lower respiratory droplets that may improve detection. We performed EBC RT-PCR for SARS-CoV-2 genes (E, S, N, ORF1ab) on NPS-positive (n=16) and NPS-negative/clinically positive COVID-19 patients (n=15) using two commercial
assays. |
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Anatomical pathology of novel coronavirus (Covid-19) infection. First impressions |
Rybakova, MG, Karev, et al |
Arkhiv Patologii |
Clinical data| Données cliniques |
The aim of the study is to analyze the thanatogenetic significance of the new coronavirus infection COVID-19 in different
age and gender groups and to describe its main pathomorphological manifestations in various organs. A comprehensive analysis of 700 autopsies for the new coronavirus infection COVID-19 was performed, including the study of macroscopic changes reflected in
the protocols of pathological and anatomical autopsies and forensic medical reports, as well as microscopic changes, organs identified during histological examination. |
|
Safavi, A, Kefayat, et al |
Vaccine |
Vaccine Research| Recherche sur les vaccins |
In this study, a novel multi-epitope vaccine against SARS-CoV-2 was designed to provoke both innate and adaptive immune
responses. The immunodominant regions of six non-structural proteins (nsp7, nsp8, nsp9, nsp10, nsp12 and nsp14) of SARS-CoV-2 were selected by multiple immunoinformatic tools to provoke T cell immune response. The designed vaccine exhibited high efficacy in
silico, further experimental validation is necessary. |
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Sah, GS, Shrestha, et al |
Cancer Management and Research |
Public Health response| Interventions de santé publique |
This study assesses the knowledge, attitudes, and practices (KAP) towards COVID-19 among the admitted cancer patients
in Nepal and is first of its kind. The overall correct response rate of the knowledge component of the questionnaire was 79.4%. Most of the participants (89.7%) had a positive attitude towards accepting isolation if they had the COVID-19 infection. Only 4.5%
reported that they had visited the crowded places recently. |
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Acceptance of e-consult for Substance Use Disorders during the COVID 19 pandemic: A study from
India |
Sahu, P, Mathur, et al |
Asian Journal of Psychiatry |
Healthcare Response | Réponse des soins de santé |
During COVID 19 pandemic lockdown in India, e-consult was an acceptable tool in managing SUDs. The majority of HCPs
could discuss their cases with addiction experts. There is a need to expand this further in other mental health conditions. |
|
Sainz-Amo, R, Baena-Álvarez, et al |
J Neurol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Institutionalization and oncologic comorbidity, rather than Parkinson’s disease (PD) related variables, increased the
risk of developing COVID-19, and impacted on its severity. These findings suggest that epidemiologic factors and frailty are key factors for COVID-19 morbidity/mortality in PD. Appropriate preventive strategies should be implemented in institutionalized patients
to prevent infection and improve prognosis. |
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Sakr, Y, Giovini, et al |
Journal of critical care |
Clinical data| Données cliniques |
A case series of five patients, representing the clinical spectrum of COVID-19 associated pulmonary thromboembolism
(PTE). The onset of PTE varies from 2 to 4 weeks after the occurrence of the initial symptoms. PTE may occur in patients without past history of risk factors for venous thromboembolism and in those receiving standard prophylactic anticoagulation. Intermediate
therapeutic dose of anticoagulants and extend thromboprophylaxis are necessary in these patients after meticulous risk-benefit assessment. |
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Santana, FelipeM, Lopes, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Conducted a prospective study with ARD patients on different synthetic or biologic DMARDs (sDMARDs or bDMARDs) and
control patients without DMARDs. All positive rRT-PCR patients showed seroconversion for anti-SARS-CoV-2 IgG. A borderline significant association was found for bDMARD use in IgG positive patients (42.9% vs. 19.8%, p=0.056). On the other hand, none of the
patients on non-antimalarial sDMARD had detectable anti-SARS-CoV-2 IgG as compared to 35.4% of the remainder sample, reaching borderline statistical significance (0.0% vs. 35.4%, p=0.050). |
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Santoro, F, Monitillo, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
After 7 days of hospitalization, 14% of patients with Covid-19 developed pQTc; age, basal heart rate and dual antiviral
therapy were found as independent predictor of pQTc. Life threatening arrhythmias have an incidence of 3.6% and were associated with poor outcome. |
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32865267; Clinical characteristics and outcomes in patients with COVID-19 and leprosy |
Santos, VS, Quintans-Júnior, et al |
Journal of the European Academy of Dermatology and Venereology |
Clinical data| Données cliniques |
This study describes the clinical characteristics and outcomes in patients with COVID‐19 and leprosy (n=4) hospitalized
in Aracaju, Sergipe state. |
|
Saravanan, M, S, et al |
Energy Sources, Part A: Recovery, Utilization and Environmental Effects |
Public health interventions*| Interventions de santé publique |
The impacts COVID-19 on the environment during lockdown conditions have been compared without lockdown conditions with
respect to variable time duration and meteorological conditions. Particulate matter concentration of Chennai, Bangalore, Delhi, and Melbourne were assessed during the lockdown period. The mitigation measures taken by governments resulted in improved air quality
particularly PM2.5 due to decreased road traffic. |
|
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Savino, M, Casula, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Describe the features and mortality of patients on ICHD in England and Wales who had laboratory-confirmed COVID-19.
Overall unadjusted survival at 1 week after date of positive COVID-19 test was 87.5% (95% CI 86.1–88.8%); mortality increased with age, treatment vintage and there was borderline evidence of Asian ethnicity (HR 1.16, 95% CI 0.94–1.44) being associated with
higher mortality. Compared to the general population, the relative risk of mortality for ICHD patients with COVID-19 was 45.4 and highest in younger adults. |
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Scharmer, C, Martinez, et al |
Int J Eat Disord |
Public Health response| Interventions de santé publique |
COVID‐19 anxiety may increase risk for eating disorder (ED) pathology and may be specifically important in determining
risk for ED pathology and compulsive exercise among individuals with lower intolerance of uncertainty. |
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Objective evaluation of odor loss in COVID-19 and other suspected cases |
Seden, N, Yiğit, et al |
American Journal of Otolaryngology - Head and Neck Medicine and Surgery |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Odor dysfunction in COVID-19 patients was objectively assessed. Patients with an odor threshold score < 5 were classified
as “Smell-Impaired Group”, patients with an odor threshold score ≥ 5 were placed in “Smell Intact Group”. The incidence of female patients in smell-impaired group was significantly higher (p ˂ 0.05). The proportion of patients who were PCR-positive for COVID-19
in smell-impaired group was significantly higher (p ˂ 0.05) than in smell intact group. Among patients with an odor threshold score from 0 to 1 (anosmic; n = 15), 12 (80%) demonstrated PCR positivity (p < 0.0001). |
|
Serin, I, Sari, et al |
Journal of Infection and Public Health |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Studies based on radiological findings have demonstrated that CT involvement has higher sensitivity in COVID-19 diagnosis.
LDH/Lymphocyte ratio was analyzed in terms of COVID-19 diagnosis and mortality with using specific CT involvement as gold standard method. This was found to be a more sensitive due to PCR false negativity; 0.06 and 0.21 were obtained as cut off values for
diagnosis and mortality. |
|
|
Serrao, Shannon, Deng, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Employ individual-based Monte Carlo computer simulations of a stochastic SEIR model variant on a two-dimensional Newman--Watts
small-world network to investigate the control of epidemic outbreaks through periodic testing and isolation of infectious individuals, and subsequent quarantine of their immediate contacts. |
|
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Reduction in heart failure hospitalization rate during coronavirus disease 19 pandemic outbreak |
Severino, P, D'Amato, et al |
ESC Heart Fail |
Healthcare Response | Réponse des soins de santé |
Investigate the rate of hospital admissions for heart failure (HF) during the early days of the COVID‐19 outbreak in
Italy, compared with a corresponding period during the previous year and an earlier period during the same year. Admissions for HF were significantly reduced during the lockdown due to the COVID‐19 pandemic in Italy. |
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Evolutionary dynamics of SARS-CoV-2 nucleocapsid (N) protein and its consequences |
Shaminur Rahman, M, Rafiul Islam, et al |
J Med Virol |
Coronavirology| Coronavirologie |
Explored 61,485 sequences of the nucleocapsid (N) protein, a potent diagnostic and prophylactic target, for identifying
the mutations to review their roles in real‐timePCR based diagnosis and observe consequent impacts. Compared to the Wuhan reference strain, a total of 1034 unique nucleotide mutations were identified in the mutant strains (49.15%, n=30,221) globally. Of these
mutations, 367 occupy primer binding sites including 3'‐end mismatch to primer‐pair of 11 well characterized primer sets. Noteworthy, CDC (USA) recommended N2 primer set contained lower mismatch than the other primer sets. 684 amino acid (aa) substitutions
located across 317 (75.66% of total aa) unique positions including 82, 21, and 83 of those in RNA binding N‐terminal domain (NTD), SR‐rich region, and C‐terminal dimerization domain (CTD), respectively. 11 in‐frame deletions, mostly (n =10) within the highly
flexible linker region, were revealed and the rest within the NTD region. predicted the possible consequence of high‐frequency mutations (≥ 20) and deletions on the tertiary structure of the N protein. Remarkably, we observed that high frequency (67.94% of
mutated sequences) co‐occuring mutations (R203K and G204R) destabilized and decreased overall structural flexibility. The N protein of SARS‐CoV‐2 comprises an average of 1.2 mutations per strain compared to 4.4 and 0.4 in MERS‐CoV and SARS‐CoV, respectively. |
|
Sheehan, StephanieA, Hamilton, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
Report that Maackia amurensis seed lectin targets the ACE2 receptor, decreases ACE2 expression and glycosylation, suppresses
binding of the SARS-CoV-2 spike protein, and decreases expression of inflammatory mediators by oral epithelial cells that cause ARDS in COVID-19 patients. |
|
|
Shi, C, Zhu, et al |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
Explore perceived barriers among type 2 diabetes patients during isolation following their recovery from COVID-19.
Barriers to diabetes self-management identified by patients with diabetes during isolation were categorized into five major themes: inadequate knowledge and behavioral beliefs, shortage of resources, suffering from health problems, negative emotions, and lack
of support. |
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Shi, P, Gao, et al |
Sustainable Cities and Society |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Analyzed data on 69 infections in Wuxi to describe the disease's characteristics, to analyze factors of cases clinical
outcome and to evaluate the prevention and control measures. The clinical severity of cases was mostly mild and normal (75.36 %). Aging (relative risk [RR] = 1.04, 95 % confidence interval [CI]: 1.001–1.08) and fever (RR = 10.33, 95 %CI: 2.75–38.78) were risk
factors for disease severity. The mean incubation period was estimated to be 4.77 days (95 % CI: 3.61–5.94), with a mean serial interval of 6.31 days (95 % CI: 5.12–7.50). The controlled reproduction number was estimated to be 1.12 (95 %CI: 0.71–1.69). |
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Shrestha, A, Shrestha, et al |
Open Access Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
Develop and implement COVID-19 ED triage and protected intubation protocols for COVID-19 patients with in-situ simulation
(ISS) training. There was a significant improvement in triage knowledge score after ISS [5.5/10 (IQR 4–6) versus 8.5/10 (IQR 8–9), p<0.001]. There was a desirable proportion of correct responses (>75%) following the ISS for triage case scenarios. A pre-designed
checklist was used during protective intubation simulations. Some important LSTs were missing medications, lack of mechanism to deliver patient samples to lab and faulty airway maneuvers. The participants’ feedback on ISS showed increased skills and confidence
level on triaging and protected intubation (p<0.001). They found the protocols easy to follow and they recommended for more such modules in future. |
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Shrestha, C, Ghimire, et al |
Journal of the Nepal Medical Association |
Public Health response| Interventions de santé publique |
Poor Mental wellbeing was more prevalent among participants less than 30 years of age, female gender, never married,
diagnosed mental disorder, living alone and those using informal sources for COVID-19 related information. More participants with lower sleep quality score and higher perceived stress score reported poor Mental wellbeing |
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Using Benford's law to assess the quality of COVID-19 register data in Brazil |
Silva, L, Figueiredo Filho, et al |
J Public Health (Oxf) |
Epidemiology| Épidémiologie |
Employ Newcomb–Benford law (NBL) to evaluate the reliability of COVID-19 figures in Brazil. Using official data from
February 25 to September 15, apply a first digit test for a national aggregate dataset of total cases and cumulative deaths. We find strong evidence that Brazilian reports do not conform to the NBL theoretical expectations. These results are robust to different
goodness of fit (chi-square, mean absolute deviation and distortion factor) and data sources (John Hopkins University and Our World in Data). Despite the growing appreciation for evidence-based-policymaking, which requires valid and reliable data, we show
that the Brazilian epidemiological surveillance system fails to provide trustful data under the NBL assumption on the COVID-19 epidemic. |
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Gout management and outcomes during the COVID-19 pandemic: a cross-sectional internet survey |
Singh, JA, Edwards, et al |
Therapeutic Advances in Musculoskeletal Disease |
Healthcare Response | Réponse des soins de santé |
Assessed medication use, healthcare utilization, gout-specific health-related quality of life (HRQoL) on the Gout Impact
Scale (GIS), psychological distress using the patient health questionnaire-4 (PHQ-4), and resilience in people with self-reported physician-diagnosed gout during the COVID-19 pandemic in a cross-sectional Internet survey. Healthcare gaps, psychological distress,
and HRQoL deficits were commonly reported by people with gout during the COVID-19 pandemic. Interventions to address these challenges for people with gout during the COVID-19 pandemic are needed. |
|
Singh, O, Bhardwaj, et al |
Environment, Development and Sustainability |
Epidemiology| Épidémiologie |
Examine the linkage between climatic variables and COVID-19 particularly in National Capital Territory of Delhi (NCT
of Delhi), India. |
|
|
Siracusano, G, Corte, et al |
Sustainability (Switzerland) |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Show how to improve the sensitivity of chest X-ray via a nonlinear post-processing tool, named PACE (Pipeline for Advanced
Contrast Enhancement), combining properly Fast and Adaptive Bidimensional Empirical Mode Decomposition (FABEMD) and Contrast Limited Adaptive Histogram Equalization (CLAHE). The results show an enhancement of the image contrast as confirmed by three widely
used metrics: (i) contrast improvement index, (ii) entropy, and (iii) measure of enhancement. This improvement gives rise to a detectability of more lung lesions as identified by two radiologists, who evaluated the images separately, and confirmed by CT-scans. |
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Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis |
Smatti, MK, Al-Sarraj, et al |
Frontiers in Genetics |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Explore the frequency of a set of genetic polymorphisms that could affect SARS-CoV-2 susceptibility or severity, including
those that were previously associated with SARS-CoV-1. A total of 74 SNPs, located in 10 genes: ICAM3, IFN-γ, CCL2, CCL5, AHSG, MBL, Furin, TMPRSS2, IL4, and CD209 promoter, were identified. Analysis of Qatari genomes revealed significantly lower AF of risk
variants linked to SARS-CoV-1 severity (CCL2, MBL, CCL5, AHSG, and IL4) compared to that of 1000Genome and/or the EAS population (up to 25-fold change). Conversely, SNPs in TMPRSS2, IFN-γ, ICAM3, and Furin were more common among Qataris (average 2-fold change).
Inter-population analysis showed that the distribution of risk alleles among Europeans differs substantially from Africans and EASs. Remarkably, Africans seem to carry extremely lower frequencies of SARS-CoV-1 susceptibility alleles, reaching to 32-fold decrease
compared to other populations. |
|
Outcome of SARS-CoV-2 and immune thrombocytopenia in a pediatric patient |
Soares, ACCV, Loggetto, et al |
Hematology, Transfusion and Cell Therapy |
Clinical data| Données cliniques |
Report the case of a previously healthy child infected with SARS-CoV-2 who developed thrombocytopenia at two different
times: during the acute infection and later, as immune thrombocytopenia (ITP), with complete response to intravenous immunoglobulin (IVIG). |
|
Soliman, MAR, Elbaroody, et al |
Surgical Neurology International |
Healthcare Response | Réponse des soins de santé |
Cross-sectional analytical survey was distributed among neurosurgeons who performed emergency surgeries during the
COVID-19 pandemic in Cairo, Egypt. The study finds, in developing countries with limited resources, preoperative screening using chest examination, CBC, and CT chest might be sufficient to replace Reverse transcription polymerase chain reaction. Developing
countries require adequate support with screening tests, PPE, and critical care equipment such as ventilators. |
|
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Solorio-Pineda, S, Almendárez-Sánchez, et al |
Surgical Neurology International |
Clinical data| Données cliniques |
Report on a 27-year-old male patient case with progressive decrease in visual acuity, associated with respiratory symptoms
and intense headache, who was later confirmed to have a SARS-Cov2 infection. |
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Stanojevic, Slavoljub Grozdan, Ponjavic, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission |
In order to better understand the epidemic dynamics and predict possible outcomes, we have developed a mathematical
model SEIRDS (S-susceptible, E-exposed, I-infected, R-recovered, D-dead due to COVID19 infection, S-susceptible). The findings from various simulation scenarios have shown that, with implementation of strict measures of contact reduction, it is possible to
control COVID19 and reduce number of deaths. The findings also show that limiting effective contacts within the most susceptible population strata merits a special attention. However, the findings also show that the disease has a potential to remain in the
population for a long time, likely with a seasonal pattern. If a vaccine, with efficacy equal or higher than 65%, becomes available it could help to significantly slow down or completely stop circulation of the virus in human population. The effects of vaccination
depend primarily on: 1. Efficacy of available vaccine(s), 2. Prioritization of the population categories for vaccination, and 3. Overall vaccination coverage of the population, assuming that the vaccine(s) develop solid immunity in vaccinated individuals.
With expected basic reproduction number of Ro=2.46 and vaccine efficacy of 68%, an 87%- coverage would be sufficient to stop the virus circulation. |
|
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Sun, H, Guo, et al |
Medical Science Monitor |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study enrolled 68 patients with novel coronavirus pneumonia. IL-6 concentrations were significantly higher in
patients with more severe than less severe COVID-19 pneumonia. Eight of 40 patients with severe COVID-19 pneumonia became critically ill and required ICU admission. IL-6 concentrations were significantly higher in patients with severe COVID-19 pneumonia who
were than who were not treated in the ICU. The area under the receiver operating characteristic (ROC) curve (AUC) was 0.816 (P<0.01), indicating that IL-6 was prognostic of disease severity in patients with COVID-19 pneumonia. |
|
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CoVA: An Acuity Score for Outpatient Screening that Predicts COVID-19 Prognosis |
Sun, H, Jain, et al |
J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
Develop an automatable score to predict hospitalization, critical illness, or death for patients at risk for COVID-19
presenting for urgent care (n=2205), COVID-19 Acuity Score (CoVA). CoVA showed excellent performance in prospective validation for hospitalization (expected-to-observed ratio (E/O): 1.01, AUC: 0.76); for critical illness (E/O 1.03, AUC: 0.79); and for death
(E/O: 1.63, AUC=0.93). Among 30 predictors, the top five were age, diastolic blood pressure, blood oxygen saturation, COVID-19 testing status, and respiratory rate. |
|
IgA Vasculitis With Nephritis (Henoch−Schönlein Purpura) in a COVID-19 Patient |
Suso, AS, Mon, et al |
Kidney International Reports |
Clinical data| Données cliniques |
We report a patient who developed systemic symptoms and renal involvement after being hospitalized because of a COVID-19
infection. A mesangial proliferation and IgA deposits in the glomeruli were seen on the kidney biopsy specimen. |
|
Suwantika, AA, Zakiyah, et al |
Data |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique Economics | Économie |
Focusing on the use of administrative and secondary data, this study aimed to estimate the costs and effects of alternative
strategies for mitigating the COVID-19 pandemic in Jakarta, Indonesia, by comparing the baseline (no intervention) with school closures (SC) + work closures (WC) for 2, 4, and 8 weeks as respective scenarios. A modified Susceptible-Exposed-Infected-Recovered
(SEIR) compartmental model accounting for the spread of infection during the latent period was applied by taking into account a 1-year time horizon. It can be concluded that all the mitigation scenarios were considered to be cost-saving, and increasing the
duration of SC and WC would increase both the savings and the number of averted deaths. |
|
|
Modelling elevator traffic with social distancing in a university classroom building |
Swinarski, D |
Building Services Engineering Research and Technology |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
We describe a model and use it to predict the elevator traffic under social distancing in a university classroom building,
and study the effects of four interventions aimed at improving this traffic. Discrete event-based simulation is used to study whether the lift group meets the forecasted demand when the car capacity is restricted far below its ordinary value to accommodate
social distancing. |
|
Taboada, M, Rama, et al |
Revista espanola de anestesiologia y reanimacion |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study is to describe the clinical ICU course, treatments used, complications and outcomes, of critically
ill COVID-19 patients admitted in seven ICU in Galicia region of Spain during the 2020 March-April pandemic peak. A high proportion of our critically ill COVID-19 patients required mechanical ventilation, prone positioning, antiviral medication, corticosteroids,
and anticoagulants. ICU complications were frequent, mainly infections and thrombotic events. We had a relatively low mortality of 15.5%. |
|
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33040779; Interleukin-6 role in the severity of COVID-19 and intensive care unit stay length |
Taher Al Barzin, RMG, Ghafour Raheem, et al |
Cellular and molecular biology (Noisy-le-Grand, France) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study examines the level of interleukin 6 as a pre-inflammatory cytokine along with other related factors to better
understand the pathogenesis of COVID-19. ICU admitted patients had higher IL6 levels. The mean interleukin 6 level was significantly higher in patients hospitalized for more than 7 days. There was no significant difference in terms of nutritional status and
albumin level between ICU admitted and ward admitted patients. Our study shows that there may be possible associations of IL6 and disease severity and ICU stay length. |
|
Talaat, F, Ramadan, et al |
Multiple Sclerosis and Related Disorders |
Public Health response| Interventions de santé publique |
The objective of this study was to evaluate whether the psychological state and behaviours of multiple sclerosis (MS)
patients and their caregivers were different from the non-MS population or not during the pandemic. In this cohort, MS patients were more anxious, stressed and depressed during the COVID-19 pandemic than their caregivers and the non-MS population, but they
were not more motivated to follow the basic preventive measures against infection. |
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Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age |
Tamanna, S, Clifton, et al |
Frontiers in Physiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study investigates whether an imbalance in angiotensin (Ang) peptides could contribute to the pathophysiology
of preeclampsia (PE) and poor fetal growth. Plasma ACE, ACE2, and Ang-(1-7) levels, and ACE2 activity were significantly higher in normal pregnant women compared with non-pregnant women; neprilysin (NEP) levels were not changed. In small of gestational age
(SGA) pregnancies, ACE and ACE2 levels were higher in early-mid pregnancy compared with normal pregnant women. In women with PE, plasma ACE, ACE2, NEP, and Ang-(1-7) levels and ACE2 activity were lower than levels in normal pregnant women. |
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32950458; SARS-CoV-2 viremia may predict rapid deterioration of COVID-19 patients |
Tan, C, Li, et al |
Brazilian Journal of Infectious Diseases |
Clinical data| Données cliniques |
We present four COVID-19 patients with positive SARS-CoV-2 nucleic acid test in blood, accounting for 12.12% of 33
detected cases. Rapid deterioration of these cases with septic shock, accompanying with lung CT images enlarged rapidly, decrease of blood oxygen, heart rate drop (with asynchrony of hypoxemia) accompanied with SARS-CoV-2 viremia. It indicates that massive
replication and releasing into blood of SARS-CoV-2 and secondary inflammation storm may lead to injury of multiple organs and poor prognosis. |
|
Head-to-head evaluation on diagnostic accuracies of six SARS-CoV-2 serological assays |
Tan, SS, Saw, et al |
Pathology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In this study, we evaluated and compared six SARS-CoV-2 serology kits including the Abbott SARS-CoV-2 IgG assay, Beckman
Access SARS-CoV-2 IgG assay, OCD Vitros OCD Anti-SARS-CoV-2 Total antibody assay, Roche Elecsys Anti SARS-CoV-2 assay, Siemens SARS-CoV-2 Total assay, and cPass surrogate viral neutralising antibody assay. All assays exhibited excellent specificity and total
antibody assays with spike protein configurations generally outperformed nucleocapsid configurations and IgG assays in terms of diagnostic sensitivity. |
|
Inferring the Trend of COVID-19 Epidemic with Close Contacts Counting |
Tan, SY, Cao, et al |
Dianzi Keji Daxue Xuebao/Journal of the University of Electronic Science and Technology of China |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
In Beijing, the proportion of close contact cases in newly confirmed cases had increased from about 50% at the end
of January to nearly 100% in mid-February, indicating that contact tracing and quarantine measures are effective non-pharmaceutical interventions for containing the epidemic. In addition, we show at the national level that the cumulative number of close contacts
was stabilized at about eight times as much as infected individuals, and the growth rate of daily close contacts was consistent with that of daily confirmed cases 5~6 days later. |
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Transferrin receptor is another receptor for SARS-CoV-2 entry |
Tang, Xiaopeng, Yang, et al |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
Here we show that ACE2 knockout dose not completely block virus entry, while TfR directly interacts with virus Spike
protein to mediate virus entry and SARS-CoV-2 can infect mice with over-expressed humanized transferrin receptor (TfR) and without humanized ACE2. Anti-TfR antibody (EC50 16.6 nM) shows promising anti-viral effects in mouse model. Collectively, this report
indicates that TfR is another receptor for SARS-CoV-2 entry and a promising anti-COVID-19 target. |
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Thelwall, M, Thelwall, et al |
Aslib Journal of Information Management |
Public Health response| Interventions de santé publique |
This article investigates important issues reflected on Twitter in the early stages of the public reaction to COVID-19.
The main themes identified for the 87 qualifying tweets accounting for 14 million retweets were: lockdown life; attitude towards social restrictions; politics; safety messages; people with COVID-19; support for key workers; work; and COVID-19 facts/news. |
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Tomisti, Luca, Pulizzi, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this retrospective case-control study was to assess and compare the serum 25OH-vitamin D levels in
three cohorts of patients hospitalized due to acute illness, either related or not to a SARS-COV-2 infection. Our data do not show lower 25OH-vitamin D levels in the patients with SARS- COV-2 pneumonia compared to patients hospitalized for other acute illnesses.
In the COVID-19 group the 25OH-vitamin D levels did not show significant correlation with a worse outcome. |
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Traneva, V, Mavrov, et al |
|
Epidemiology| Épidémiologie |
In this paper we apply an intuitionistic fuzzy two-factor ANOVA (2-D IFANOVA), based on the concepts of intuitionistic
fuzzy sets (IFSs) and index matrices (IMs), over a unique dataset of daily COVID-19 cases up to 24 June 2020 to explore how the number of COVID-19 cases depends on the "density"and "climate zone"factors for the continent of Europe. |
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Traugott, Marianna, Hoepler, et al |
Research Square prepub |
Clinical data| Données cliniques |
We report the case of a patient with severe neurogenic post-extubation dysphagia due to prolonged intubation and severe
general muscle weakness related to COVID-19, which was successfully treated using Pharyngeal Electrical Stimulation. |
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Single-cell analyses reveal SARS-CoV-2 interference with intrinsic
immune response in the human gut |
Triana, Sergio, Metz Zumaran, et al |
bioRxiv |
Clinical data| Données cliniques |
Despite the mounting evidence about SARS-CoV-2 infecting the human gut, little is known about the antiviral programs
triggered in this organ. To address this gap, we performed single-cell transcriptomics of SARS-CoV-2-infected intestinal organoids. We identified a subpopulation of enterocytes as the prime target of SARS-CoV-2 and, interestingly, found the lack of positive
correlation between susceptibility to infection and the expression of ACE2. Findings reveal that SARS-CoV-2 curtails the immune response and highlights the gut as a proinflammatory reservoir that should be considered to fully understand SARS-CoV-2 pathogenesis. |
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Equation for epidemic spread with the quarantine measures: Application to COVID-19 |
Trigger, SA, Czerniawski, et al |
Physica Scripta |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this study, a new equation for infection spread in a finite population is found. The developed model for a free
epidemic based on four natural parameters: the size of population, the number of dangerous contacts of one infected person per day, the probability to obtain infection due to dangerous contact and the duration of the disease. |
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Physical activity, night eating, and mood state profiles of athletes during the COVID-19 pandemic |
Turgut, M, Soylu, et al |
Progress in Nutrition |
Public Health response| Interventions de santé publique |
The aim of this study was to examine the effect of COVID-19 Pandemic physical activity, night eating, and mood in athletes.
During the COVID-19 pandemic, athletes could remain physically active, but because of the negative effects of staying home in daily life, it had negative effects on night-time eating behaviour and mood. |
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Decentralized COVID-19 measures in Brazil were ineffective to protect people with diabetes |
Ugliara Barone, MT, Harnik, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Healthcare Response | Réponse des soins de santé |
During the pandemic, interventions recommended globally for people with diabetes were to keep blood glucose on target
whilst staying at home to curb the spread of the virus. In Brazil, similar measures were proposed. The aim of our observational study was to assess whether these measures achieved their objectives. 22.51% of the individuals with diabetes benefited from the
distribution of medicines and supplies enough for 3 months. 50.08% experienced increase or higher glycemic variability during the COVID-19 pandemic. Measures to protect individuals with diabetes during the COVID-19 pandemic were not effective for most of this
population. |
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Usman, E, Nindrea, et al |
Systematic Reviews in Pharmacy |
Public Health response| Interventions de santé publique |
This study conducted correlation of google trends as an alternative information source in the early stages of COVID-19
outbreak in Indonesia. Moving average analysis showed a linear time series pattern between COVID-19 search trends and the official COVID-19 report. Time lag correlation inference COVID-19 search trends data could possibly be utilized for an early identification
of public reaction against the increasing cases of COVID-19. |
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PMC7582442; Tinnitus and equilibrium disorders in COVID-19 patients: preliminary results |
Viola, P, Ralli, et al |
Eur Arch Otorhinolaryngol |
Clinical data| Données cliniques |
The aim of this study was to study the prevalence of subjective tinnitus and dizziness in a sample of COVID-19 patients
using an online 10-item close-ended questionnaire in Italy. Thirty-four patients (18.4%) reported equilibrium disorders after COVID-19 diagnosis. Of these, 32 patients reported dizziness (94.1%) and 2 (5.9%) reported acute vertigo attacks. Forty-three patients
(23.2%) reported tinnitus; 14 (7.6%) reported both tinnitus and equilibrium disorders. |
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Wai, KC, Xu, et al |
Head Neck |
Healthcare Response | Réponse des soins de santé |
In this study, we aim to understand how the surgical care of head and neck cancer patients was affected by COVID-19.
During COVID-19, perioperative outcomes were similar, operative time increased, and there were no recorded transmissions to staff or patients. |
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Wang, Bin, An, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We conducted a retrospective combined cohort study to analyze the associations between the number of prenatal examinations
(NPE), delivery gestational week (DGW), the risk of caesarean section (CS), stillbirth, neonatal weight, preterm birth, macrosomia, small for gestational age (SGA), large for gestational age (LGA) and the COVID-19 in two time-periods, the pre-pandemic period
and the pandemic period. The CS and preterm birth rates increased slightly in areas that were more affected by the pandemic than other areas among uninfected pregnant women. NPEs were not significantly interrupted and most maternal and neonatal clinical characteristics
were within the normal ranges. |
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Wei, J, Wang, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission
Public health interventions*| Interventions de santé publique |
In this paper, the interaction strategies and the evolutionary game analysis of the actions taken by the government
and the public in the early days of the epidemic are incorporated into the natural transmission mechanism model of the epidemic, and then the transmission frequency equations of COVID-19 epidemic is established. The analysis result shows that the emergency
response strategy adopted by the government in the early days of the epidemic can effectively control the spread of the epidemic. |
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Westgard, BC, Morgan, et al |
Ann Emerg Med |
Healthcare Response | Réponse des soins de santé |
We conducted an observational study, examining demographics, visit characteristics, and diagnoses for all emergency
department (ED) patient visits to an urban level 1 trauma center before and after a state emergency declaration and comparing them with a similar period in 2019. After the state declaration, there was a 49.3% decline in ED visits overall. Disproportionate
declines were seen in visits by pediatric and older patients, women, and Medicare recipients, as well as for presentations of syncope, cerebrovascular accidents, urolithiasis, and abdominal and back pain. Significant proportional increases were seen in ED
visits for upper respiratory infections, shortness of breath, and chest pain. |
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Wijngaards, I, Sisouw de Zilwa, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
This study tested the hypothesis that extraversion moderates the relationship between the stringency of COVID-19 protective
measures and depressive symptoms. Findings demonstrate that extraversion moderates the relationship between measure stringency in the early days of the pandemic and depressive symptoms. For introverts, measure stringency has a negative effect on depressive
symptoms, while for extraverts, it has a positive, but non-significant effect on depressive symptoms. |
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Benefits and barriers to pediatric tele-urology during the COVID-19 pandemic |
Winkelman, AJ, Beller, et al |
Journal of Pediatric Urology |
Healthcare Response | Réponse des soins de santé |
Describe our experience in rapidly introducing video visits in a tertiary academic pediatric urology practice, serving
primarily rural patients during the COVID-19 pandemic. Out of 116 attempted visits, 81% were successful. The top two reasons for failure were “no-show” (64%) and inability to connect (14%). Success versus failure of visit was similar for patient age, sex,
type of visit (initial vs. established), and socioeconomic status. After adjusting for race, socioeconomic status, and type of provider, having public insurance remained a significant predictor of failure. Successful visits were conducted on multiple common
pediatric urologic problems (excluding visits requiring palpation on exam), and video was sufficient for physical exams in most cases. A median of 2.25 h of travel time was saved. |
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COVID-19 rehabilitation delivered via a telehealth pulmonary rehabilitation model: a case series |
Wootton, SL, King, et al |
Respirology Case Reports |
Healthcare Response | Réponse des soins de santé |
International statements have suggested the pulmonary rehabilitation (PR) model as an appropriate rehabilitation option
for people recovering from coronavirus disease 2019 (COVID-19). In this case series, we present our COVID-19 telehealth rehabilitation programme, delivered within a PR setting, and discuss the management of our first three cases. All patients were male, with
a median age of 73 years. Following hospital discharge, the patients presented with persistent limitations and/or symptoms (e.g. breathlessness, fatigue, and reduced exercise capacity) which warranted community-based rehabilitation. Patients were assessed
and provided with an initial six-week rehabilitation programme supported via telehealth using a treatable traits approach. Patients demonstrated improvements in exercise capacity and breathlessness; however, fatigue levels worsened in two cases and this was
attributed to the difficulties of managing returning to work and/or carer responsibilities whilst trying to recover from a severe illness. We found that PR clinicians were well prepared and able to provide an individualized rehabilitation programme for people
recovering from COVID-19. © 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. |
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Wu, Dandan, Yang, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
Patients with coronavirus disease 2019 (COVID-19) predominantly have a respiratory tract infection with various symptoms
and high mortality is associated with respiratory failure second to severe disease. The risk factors leading to severe disease remain unclear. Here, we reanalyzed a published single-cell RNA-Seq (scRNA-Seq) dataset and found that bronchoalveolar lavage fluid
(BALF) of patients with severe disease compared to those with mild disease contained decreased TH17 type cells, decreased IFNA1 expressing cells with lower expression of toll-like receptor 7 (TLR7) and TLR8, increased IgA expressing B cells, and increased
hyperactive epithelial cells (and/or macrophages) expressing matrix metalloproteinases (MMPs), Hyaluronan synthase 2 (HAS2), and Plasminogen activator inhibitor-1 (PAI-1), which may together contribute to the pulmonary pathology in severe COVID-19. We propose
IFN-I (and TLR7/TLR8) and PAI-1 as potential biomarkers to predict the susceptibility to severe COVID19.Competing Interest StatementThe authors have declared no competing interest. |
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Wu, Y, Kwakkenbos, et al |
Journal of psychosomatic research |
Public Health response| Interventions de santé publique |
Developed and validated the COVID-19 Fears Questionnaire for Chronic Medical Conditions. 787 participants completed
baseline measures; 563 of them completed the follow-up assessment. Ten of 15 initial items were included in the final questionnaire. EFA suggested that a single dimension explained the data reasonably well. There were no indications of floor or ceiling effects.
Cronbach's alpha was 0.91. Correlations between the COVID-19 Fears Questionnaire and measures of anxiety (r = 0.53), depressive symptoms (r = 0.44), and perceived stress (r = 0.50) supported construct validity. CFA supported the single-factor structure (χ2(35)
= 311.2, p < 0.001, Tucker-Lewis Index = 0.97, Comparative Fit Index = 0.96, Root Mean Square Error of Approximation = 0.12). The COVID-19 Fears Questionnaire for Chronic Medical Conditions can be used to assess fear among people at risk due to pre-existing
medical conditions during the COVID-19 pandemic. |
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Xian, Hongxu, Liu, et al |
SSRN- Lancet prepublication |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We show that metformin inhibits IL-6 and IL-1β secretion from LPS or SARS-CoV-2 Spike protein primed macrophages undergoing
NLRP3 inflammasome activation, a key to ARDS initiation. Reduced IL-6 production correlates with blunted NFAT and C/EBPβ/NFIL-6 activation, whereas inhibition of IL-1β secretion reflects interference with NLRP3 inflammasome activation. By targeting electron
transfer chain complex 1, but independently of AMPK and mitophagy, metformin inhibits ATP-dependent mitochondrial DNA synthesis and blocks generation of oxidized mitochondrial DNA, a trigger of inflammasome assembly. Correspondingly, short-term metformin treatment
abrogates LPS-induced ARDS, lung macrophage recruitment, damage and mortality. We suggest that metformin, a cheap and safe drug, can be used to prevent ARDS onset in COVID-19 patients. |
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Xian, M, Carey, et al |
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Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Testing and early diagnostic play vital parts in control and prevention for COVID-19 and cardiac diseases. We hereby
demonstrate an electrochemical detection system for SARS-CoV-2 and cardiac troponin I with field effect transistor (FET) based biosensor hardware with low cost and disposable sensor unit. © 2020 IEEE. |
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Xiong, Q, Xu, et al |
Clinical Microbiology and Infection |
Clinical data| Données cliniques |
Describe the prevalence, nature and risk factors for the main clinical sequelae in coronavirus disease 2019 (COVID-19)
survivors who have been discharged from the hospital for more than 3 months. Among 538 survivors (54.5% female), the median age was 52.0 years, and the time from discharge from hospital to first follow-up was 97.0 days. Clinical sequelae were common, including
general symptoms (49.6%), respiratory symptoms (39%), cardiovascular-related symptoms (13%), psychosocial symptoms (22.7%) and alopecia (28.6%). We found that physical decline/fatigue, postactivity polypnoea and alopecia were more common in female than in
male subjects. Dyspnoea during hospitalization was associated with subsequent physical decline/fatigue, postactivity polypnoea and resting heart rate increases but not specifically with alopecia. A history of asthma during hospitalization was associated with
subsequent postactivity polypnoea sequela. A history of pulse ≥90 bpm during hospitalization was associated with resting heart rate increase in convalescence. The duration of virus shedding after COVID-19 onset and hospital length of stay were longer in survivors
with physical decline/fatigue or postactivity polypnoea than in those without. |
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Investigation of the discomforts of the medical staff in COVID-19 isolation room |
Xu, L, Liu, et al |
Journal of Shanghai Jiaotong University (Medical Science) |
Healthcare Response | Réponse des soins de santé |
Investigated the occurrence of medical staff leaving the COVID-19 isolation room due to discomforts and to provide
reference for clinical prevention and treatment. Among the 227 medical staff working in Leishenshan Hospital in Wuhan, Hubei Province, who were assisted by Shanghai, 69 (30.4%) staff left earlier due to discomforts while working in the isolation room. Two
of them had syncope, and sixty-seven of them had symptoms and signs related to presyncope. Symptoms of presyncope include headache, nausea, sweating, dyspnea, and palpitations, etc. Univariate analysis revealed statistically significant differences in occupation
(P=0.002), gender (P=0.006), and standing time (P=0.002). Logistic regression analysis showed that occupation (P=0.000), standing time (P=0.025), and hunger (P=0.029) were statistically significant. |
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Xu, Xiuying, Li, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
Examined the prevalence of insomnia symptoms and its association with quality of life (QOL) in clinically stable older
psychiatric patients during the COVID-19 outbreak. A total of 941 patients were recruited. The prevalence of insomnia symptoms was 57.1%. Analysis of covariance revealed that QOL was significantly lower in patients with insomnia symptoms compared to those
without them (P<0.01). Multivariate logistic regression analysis showed that insomnia symptoms were positively and independently associated with more severe depressive symptoms (P<0.01). Compared to patients with major depressive disorder, those with other
psychiatric diagnoses had significantly higher prevalence of insomnia symptoms (P=0.03). |
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Xu, Z, Yang, et al |
Frontiers in Molecular Biosciences |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The outbreak of 2019 novel coronavirus (COVID-19) has caused serious threat to public health. Discovery of new anti-COVID-19
drugs is urgently needed. Fortunately, the crystal structure of COVID-19 3CL proteinase was recently resolved. The proteinase has been identified as a promising target for drug discovery in this crisis. Here, a dataset including 2030 natural compounds was
screened and refined based on the machine learning and molecular docking. The performance of six machine learning (ML) methods of predicting active coronavirus inhibitors had achieved satisfactory accuracy, especially, the AUC (Area Under ROC Curve) scores
with fivefold cross-validation of Logistic Regression (LR) reached up to 0.976. Comprehensive ML prediction and molecular docking results accounted for the compound Rutin, which was approved by NMPA (National Medical Products Administration), exhibited the
best AUC and the most promising binding affinity compared to other compounds. Therefore, Rutin might be a promising agent in anti-COVID-19 drugs development. © Copyright © 2020 Xu, Yang, Zhang, Zhang, Yang, Liu, Wei and Liu. |
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Yakubu, Saidu Yusuf |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
Determined the level of preparedness and fears of anaesthesia staff regarding the management of COVID-19 patients in
a low resource tertiary hospital in Zaria, Nigeria. Data reported was from the survey of consenting anaesthesia staff at the Ahmadu Bello University Teaching Hospital Zaria. Information obtained include age, gender, marital status, professional role, level
of preparedness, availability of working materials/equipment, fear of COVID-19, level of stress, stigmatization and the willingness or otherwise to volunteer in the management of COVID-19 patients. All 45 respondents stated that they do not have a life insurance.
Forty four (97.8%) lack access to COVID-19 testing while 36 (80%) have not received any training on COVID-19 and the use of personal protective equipment. Twenty eight of 43 staff said that they were not willing or prepared to participate in the management
of COVID-19 patients. |
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Yang, CJ, Liu, et al |
Journal of International Pharmaceutical Research |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Compared and analyzed 7 new coronavirus nucleic acid detection kits and 5 nucleic acid extraction methods. The brand
A nucleic acid extraction kit had the highest positive rate and the lowest rate of missed detection; comparison of nucleic acid extraction methods showed that the manual column extraction method had the highest positive rate, followed by the magnetic bead
extraction method, and the one-step extraction method had the highest missed detection rate. The detection capabilities of the SARS-CoV-2 detection kits are uneven, so evaluation work needs to be done before the selection of the kit. The manual column extraction
method showed best extraction efficiency but took a long time. Because of the possible combination with the automatic nucleic acid extraction instrument, the magnetic bead extraction method had a high extraction efficacy, which might be suitable for use in
the ex- traction of large batches of samples. Although the one-step extraction method was easily operable, the method had a high missed detection rate, so this method was not recommended for clinical use. |
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Yao, M, Wang, et al |
Nonlinear Dynamics |
Therapeutics| Thérapeutique |
The 2019-nCoV is ravaging the world, taking lots of lives, and it is emergent to find a solution to deal with this
novel pneumonia. This paper provides a potential treatment for COVID-19 utilizing resonance to destroy the infection ability of 2019-nCoV. Firstly, the geometry size of 2019-nCoV is scaled up by 10,000 times. The additional mass is used to represent the effect
of the fluid around a spike protein. The finite element analysis (FEA) is used to study the modal characteristics of the tuned 2019-nCoV model and mistuned 2019-nCoV model in blood, respectively. Based on FEA, the lumped parameter mechanical model of 2019-nCoV
is established. Then, the dynamic responses of mistuned 2019-nCoV are investigated through harmonic response and dynamical analysis. Finally, a potential method utilizing 360° sweep excitation to cure COVID-19 is put forward. © 2020, Springer Nature B.V. |
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Ye, Y, Hou, et al |
IEEE journal of biomedical and health informatics |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Propose and develop an AI-driven system (named α-Satellite), as an initial offering, to provide dynamic COVID-19 risk
assessment in the United States. More specifically, given a point of interest (POI), the system will automatically provide risk indices associated with it in a hierarchical manner (e.g., state, county, POI) to enable people to select appropriate actions for
protection while minimizing disruptions to daily life. As of June 18, 2020, α-Satellite has had 56,980 users. Based on the feedback from its large-scale users, we perform further analysis and have three key findings: i) people from more severe regions (i.e.,
with larger numbers of COVID-19 cases) have stronger interests using our system to assist with actionable information; ii) users are more concerned about their nearby areas in terms of COVID-19 risks; iii) the user feedback about their perceptions towards
COVID-19 risks of their query POIs indicate the challenge of public concerns about the safety versus its negative effects on society and the economy. |
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On the study of full transmission dynamics of COVID-19 in Wuhan |
You, Chong, Gai, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
The current outbreak of coronavirus disease 2019 (COVID-19) has quickly spread across countries and become a global
crisis. Understanding the transmission mechanism and effects of interventions is critical to the prevention and control of the COVID-19 pandemic. A recent study by Hao et al (2020) provided an interesting perspective on the transmission dynamics of COVID-19
in Wuhan and inferred that 87% of the infections before 8 March 2020 were not laboratory-confirmed. However we believe that there are a few major issues due to the vagueness in the definitions of compartments and inconsistence in the settings of parameters.
In this paper, we clarify the definitions of the model compartments and raise questions in regard to the underlying homogenous assumption within compartments and settings of the parameters in the dynamic model by Hao et al (2020), and furthermore offer a modified
model to resolve these potential limitations. Compared with the model in Hao et al (2020), the active virus carriers were predicted to persist for a longer period in our model which is well consistent with the active virus carriers detected in Wuhan in mid-May.
Our model suggests that control measures cannot be easily lifted while continuous efforts are needed to contain the spread of the pandemic; a universal PT-PCR screening is essential to detect hidden cases before lifting control measure. In addition, we also
provide a possible solution to solve the problem of heterogeneity transmission rate in disease courses. |
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Youssef, N, Mostafa, et al |
Eastern Mediterranean Health Journal |
Healthcare Response | Réponse des soins de santé |
Evaluate and compare perceived adverse psychological symptoms (stress, anxiety, depression), and insomnia by health-care
professionals working in quarantine and non-quarantine hospitals during the COVID-19 pandemic in Egypt, and to explore associated factors with adverse psychological symptoms and insomnia. Five hundred and forty health-care professionals participated; 10.2%
worked in quarantine hospitals. Younger age, being not ready/sure of readiness to work in quarantine hospital, and insomnia significantly predicted stress, depression and anxiety, respectively. Being female could also significantly predict stress and anxiety. |
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CGNet: A graph-knowledge embedded convolutional neural network for detection of pneumonia |
Yu, X, Wang, et al |
Information Processing and Management |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Developed a deep learning framework for a binary classification task that classifies chest X-ray images into normal
and pneumonia based on our proposed CGNet. In our CGNet, there are three components including feature extraction, graph-based feature reconstruction and classification. Our model achieved the best accuracy at 0.9872, sensitivity at 1 and specificity at 0.9795
on a public pneumonia dataset that includes 5,856 chest X-ray images. To evaluate the performance of our proposed method on detection of pneumonia caused by COVID-19, we also tested the proposed method on a public COVID-19 CT dataset, where we achieved the
highest performance at the accuracy of 0.99, specificity at 1 and sensitivity at 0.98, respectively. |
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Yu, Z, Kan, et al |
Food Chemistry |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The present study aimed to identify potential SARS-CoV-2 inhibitory peptides from tuna protein by virtual screening.
The molecular docking was performed to elicit the interaction mechanism between targets (Mpro and ACE2) and peptides. As a result, a potential antiviral peptide EEAGGATAAQIEM (E-M) was identified. Molecular docking analysis revealed that E-M could interact
with residues Thr190, Thr25, Thr26, Ala191, Leu50, Met165, Gln189, Glu166, His164, His41, Cys145, Gly143, and Asn119 of Mpro via 11 conventional hydrogen bonds, 9 carbon hydrogen bonds, and one alkyl interaction. The formation of hydrogen bonds between peptide
E-M and the residues Gly143 and Gln189 of Mpro may play important roles in inhibiting the activity of Mpro. Besides, E-M could bind with the residues His34, Phe28, Thr27, Ala36, Asp355, Glu37, Gln24, Ser19, Tyr83, and Tyr41 of ACE2. Hydrogen bonds and electrostatic
interactions may play vital roles in blocking the receptor ACE2 binding with SARS-CoV-2. © 2020 Elsevier Ltd |
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Zaigham, Mehreen, Holmberg, et al |
Research Square prepub |
Transmission Clinical data| Données cliniques |
Demonstrate a confirmed case of transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in
the third trimester. Comprehensive virological, pathological and genetic investigations establish that intrauterine SARS-CoV-2 transmission occurred via the following chain of events; I) maternal viremia in a seemingly mildly symptomatic patient, II) high
viral load in the placenta with massive perivillous fibrin deposition, acute intervillositis in areas with strong positivity for SARS-CoV-2 and chorangiosis in the areas less affected by infection and inflammation, III) intrauterine fetal distress with pathological
cardiotocography and acidemia in validated umbilical cord blood gases and IV) mild neonatal COVID-19. Whole genome sequencing of isolates from the mother and placenta revealed a single variant of the virus. Interestingly, the neonate displayed a mixed SARS-CoV-2
population, harboring both an identical strain to the mother as well as a population with one single-nucleotide polymorphism difference, indicating intrapatient genetic drift. |
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Proteomic characteristics of bronchoalveolar lavage fluid in critical COVID-19 patients |
Zeng, HL, Di, et al |
Febs j |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
Performed a quantitative proteomic analysis of the bronchoalveolar lavage fluid (BALF) from patients with critical
COVID-19 and from non-COVID-19 controls. Our study identified 358 differentially expressed BALF proteins (p < 0.05), among which 41 were significantly changed after using the Benjamini-Hochberg correction (q < 0.05). The up-regulated signaling was found to
be mainly involved in inflammatory signaling and response to oxidative stress. A series of increased extracellular factors including Tenascin-C (TNC), Mucin-1 (KL-6 or MUC1), Lipocalin-2 (LCN2), periostin (POSTN), Chitinase 3-like 1 (CHI3L1 or YKL40), S100A12,
as well as the antigens including lymphocyte antigen 6D /E48 antigen (LY6D), CD9 antigen, CD177 antigen, prostate stem cell antigen (PSCA) were identified. Among which, the pro-inflammatory factor TNC and KL-6, that were further validated in serum of another
thirty-nine COVID-19 patients and healthy controls, showing high potentials of being biomarkers or therapeutic candidates for COVID-19. |
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Impact of COVID-19 pandemic on radiographers in the Republic of Cyprus. A questionnaire survey |
Zervides, C, Sassi, et al |
Radiography |
Healthcare Response | Réponse des soins de santé |
Assessed the insight of radiographers on how the COVID-19 pandemic has affected their work routine and if protective
measures are applied. Out of 350 registered radiographers, 101 responses were received. The results showed that there are statistically significant differences regarding the working hours, the feeling of stress, the work effectiveness, the average examination
time, the presence of a protocol used among the different workplaces of the participants; a private radiology centre, a private hospital or a public hospital. Also, statistically significant differences were observed in the decontamination methods used for
equipment, for air and when decontamination takes place among the different workplaces of the participants. Nonetheless, the majority of radiographers believe that their workplace is sufficiently provided with PPE, cleaning supplies, equipment, and with cleaning
personnel and are optimistic regarding the adequacy of these provisions in the next three months. |
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Zhang, Changhui, Li, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
The pandemic outbreak of coronavirus disease 2019 (COVID-19) across the world has led to millions of infection cases
and caused a global public health crisis. Current research suggests that SARS-CoV-2 is a highly contagious coronavirus that spreads rapidly through communities. To understand the mechanisms of viral replication, it is imperative to observe coronavirus viral
replicase, a huge protein complex comprising up to 16 viral nonstructural and associated host proteins, which is the most promising antiviral target for inhibiting viral genome replication and transcription. Recently, several components of the viral replicase
complex in SARS-CoV-2 have been solved to provide a basis for the design of new antiviral therapeutics. Here, we report the crystal structure of the SARS-CoV2 nsp7-8 tetramer, which comprises two copies of each protein representing nsp7’s full-length and the
C-terminus of nsp8 owing to N-terminus proteolysis during the process of crystallization. We also identified a long helical extension and highly flexible N-terminal domain of nsp8, which is preferred for interacting with single-stranded nucleic acids. |
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Zhang, Chiyu, Forsdyke, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The energetics of the folding of a single-stranded nucleic acid into a stem-loop structure depend on both the composition
and order of its bases. Composition tends to reflect genome-wide evolutionary pressures. Order better reflects local pressures. Base order is likely to be conserved when encoding a function critical for survival. The base order-dependent component of the folding
energy has shown that a highly conserved region in HIV-1 genomes associates with an RNA structure. This corresponds to a packaging signal that is specifically recognized by the nucleocapsid domain of the Gag polyprotein. Long viewed as a potential HIV-1 "Achilles
heel," the signal can be targeted by a recently described antiviral compound (NSC 260594) or by synthetic oligonucleotides. Thus, a conserved base-order-rich region of HIV-1 may facilitate therapeutic attack. Although SARS-CoV-2 differs in many respects from
HIV-1, the same technology displays regions with a high base order-dependent folding energy component, which are also highly conserved. This indicates structural invariance (SI) sustained by natural selection. While the regions are often also protein-encoding
(e.g. NSP3, ORF3a), we suggest that their nucleic acid level functions, such as the ribosomal frameshifting element (FSE) that facilitates differential expression of 1a and 1ab polyproteins, can be considered potential "Achilles heels" for SARS-CoV-2 that
should be susceptible to therapies like those envisaged for AIDS. The region of the FSE scored well, but higher SI scores were obtained in other regions, including those encoding NSP13 and the nucleocapsid (N) protein.Competing Interest StatementThe authors
have declared no competing interest. |
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Zhang, W, Govindavari, et al |
JAMA network open |
Transmission Coronavirology| Coronavirologie |
Determined the transmission routes of SARS-CoV-2 to Southern California and elucidate local community spread within
the Los Angeles metropolitan area. The cohort included 192 patients (median age 59.5 years; 57.3% men). The genetic characterization of SARS-CoV-2 isolates in the Los Angeles population pinpointed community transmission of 13 patients within a 3.81 km2 radius.
Variation landscapes of this case series also revealed a cluster of 10 patients that contained 5 residents at a skilled nursing facility, 1 resident of a nearby skilled nursing facility, 3 health care workers, and a family member of a resident of one of the
skilled nursing facilities. Person-to-person transmission was detected in a cluster of 5 patients who shared the same single-nucleotide variation in their SARS-CoV-2 genomes. High viral genomic diversity was identified: 20 Los Angeles isolates (15.0%) resembled
SARS-CoV-2 genomes from Asia, while 109 Los Angeles isolates (82.0%) were similar to isolates originating from Europe. Analysis of other common respiratory viral pathogens did not reveal coinfection in the cohort. |
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Zhang, X, Pellegrino, et al |
Applied Energy |
Public health interventions*| Interventions de santé publique |
Investigated the impact of the confined measures due to COVID-19 outbreak on energy demand of a building mix in a district.
Three levels of confinement for occupant schedules are proposed based on a new district design in Sweden. By comparing with the base case (normal life without confinement measures), the average delivered electricity demand of the entire district increases
in a range of 14.3% to 18.7% under the three confinement scenarios. However, the mean system energy demands (sum of heating, cooling, and domestic hot water) decreases in a range of 7.1% to 12.0%. These two variation nearly cancel each other out, leaving the
total energy demand almost unaffected. The result also shows that the delivered electricity demands in all cases have a relatively smooth variation across a year, while the system energy demands follow the principle trends for all the cases, which have peak
demands in winter and much lower demands in transit seasons and summer. |
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Zhang, X, Xue, et al |
Journal of Integrative Medicine |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Investigated the clinical efficacy of Tanreqing Capsule (TRQC) in the treatment of COVID-19. The treatment group was
given TRQC orally three times a day, three pills each time, in addition to conventional Western medicine treatments which were also administered to the control group. COVID-19 patients in the treatment group, compared to the control group, had a shorter negative
conversion time of fecal nucleic acid (4 vs. 9 days) and a shorter interval of negative conversion of pharyngeal-fecal nucleic acid (0 vs. 2 days). The level of CD3+ T cells increased in the treatment group compared to the control group (317.09 ± 274.39 vs.
175.02 ± 239.95 counts/μL). No statistically significant differences were detected in the median improvement in levels of CD4+ T cells (173 vs. 107 counts/μL) and CD45+ T cells (366 vs. 141 counts/μL) between the treatment and control groups. |
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Zhao, Y, Shang, et al |
Signal Transduct Target Ther |
Clinical data| Données cliniques |
Investigated whether breastmilk production is affected by COVID-19 and whether breastfeeding is still a safe or recommended
operation for COVID-19 puerperant women. Proteomics and metabolomics uncovered the significant alternations of numerous breastmilk proteins and metabolites associated with COVID-19. Notably, differentially expressed proteins in breastmilk of COVID-19 patients
mainly enriched in immune responses. Microbial metabolites derived from aromatic amino acids via the bacterial pathways in breastmilk of COVID-19 patients were also significantly altered. Overall, this work suggests that breastfeeding of such breastmilk with
deficiency of immune-related components may not be conducive to neonates for establishing immune defense in their early life. |
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Zhou, Jiandong, Lee, et al |
medRxiv |
Clinical data| Données cliniques |
Developed a simple risk score for severe COVID-19 disease using territory-wide healthcare data based on simple clinical
and laboratory variables. COVID-19 testing was performed in 237493 patients and 4445 patients (median age 44.8 years; 50% male) were tested positive. Of these, 212 patients met the primary outcome. A risk score including the following components was derived
from Cox regression: gender, age, hypertension, stroke, diabetes mellitus, ischemic heart disease/heart failure, respiratory disease, renal disease, increases in neutrophil count, monocyte count, sodium, potassium, urea, alanine transaminase, alkaline phosphatase,
high sensitive troponin-I, prothrombin time, activated partial thromboplastin time, D-dimer and C-reactive protein, as well as decreases in lymphocyte count, base excess and bicarbonate levels. The model based on test results taken on the day of admission
demonstrated an excellent predictive value. Incorporation of test results on successive time points did not further improve risk prediction. |
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Zhou, Jianli, Qin, et al |
medRxiv |
Epidemiology| Épidémiologie Transmission |
Investigated the association between ambient air pollutants, meteorological factors and their interaction on confirmed
case counts of COVID-19 in 120 Chinese cities. We modeled total confirmed cases of COVID-19 with meteorological factors, air pollutants and their interactions. Positive associations were found between the number of confirmed cases of COVID-19 and carbon monoxide,
aerodynamic particulate matter with aerodynamic diameter ≤2.5 µm, relative humidity and ozone, with and without migration scale index (MSI)-adjustment. Negative associations were also found for sulfur dioxide and wind velocity both with and without controlling
for population migration. In addition, air pollutants and meteorological factors had interactive effects on COVID-19 after controlling for MSI. |
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Zhou, L, Yao, et al |
Journal of Aerosol Science |
Epidemiology| Épidémiologie Surveillance |
The COVID-19 pandemic has brought an unprecedented crisis to the global health sector. When discharging COVID-19 patients
in accordance with throat or nasal swab protocols using RT-PCR, the potential risk of reintroducing the infection source to humans and the environment must be resolved. Here, 14 patients including 10 COVID-19 subjects were recruited; exhaled breath condensate
(EBC), air samples and surface swabs were collected and analyzed for SARS-CoV-2 using reverse transcription-polymerase chain reaction (RT-PCR) in four hospitals with applied natural ventilation and disinfection practices in Wuhan. Here we discovered that 22.2%
of COVID-19 patients (n = 9), who were ready for hospital discharge based on current guidelines, had SARS-CoV-2 in their exhaled breath (~105 RNA copies/m3). Although fewer surface swabs (3.1%, n = 318) tested positive, medical equipment such as face shield
frequently contacted/used by healthcare workers and the work shift floor were contaminated by SARS-CoV-2 (3–8 viruses/cm2). Three of the air samples (n = 44) including those collected using a robot-assisted sampler were detected positive by a digital PCR with
a concentration level of 9–219 viruses/m3. RT-PCR diagnosis using throat swab specimens had a failure rate of more than 22% in safely discharging COVID-19 patients who were otherwise still exhaling the SARS-CoV-2 by a rate of estimated ~1400 RNA copies per
minute into the air. Direct surface contact might not represent a major transmission route, and lower positive rate of air sample (6.8%) was likely due to natural ventilation (1.6–3.3 m/s) and regular disinfection practices. While there is a critical need
for strengthening hospital discharge standards in preventing re-emergence of COVID-19 spread, use of breath sample as a supplement specimen could further guard the hospital discharge to ensure the safety of the public and minimize the pandemic re-emergence
risk. © 2020 Elsevier Ltd |
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Zieleskiewicz, L, Duclos, et al |
Anaesthesia, critical care & pain medicine |
Clinical data| Données cliniques |
Report two cases of confirmed COVID-19 patients are described at early and late stages of the disease. We compared
the CT scan and ultrasound features performed at the same time. Underline the potential of LUS for COVID-19 pneumonia assessment at different stages of the disease. When the clinical context is evocative, LUS may therefore help physicians to identify COVID-19
patients. After a proper validation of LUS against chest CT scan, one can believe that LUS could serve as a diagnostic and a triage tool detecting at risk patients |
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First responders and social distancing during the COVID-19 pandemic |
Zolnikov, TR, Furio, et al |
Journal of Human Behavior in the Social Environment |
Healthcare Response | Réponse des soins de santé |
Social distancing is the practice of physically distancing (e.g., 6 feet away) from other people. Social distancing
has been implemented as the primary intervention against the COVID-19 pandemic to reduce transmission of the virus between people. While this is beneficial, there are effects that could result from the lack of social interaction. This study reviewed the effects
of social distancing on first responders—an at-risk population who were the most exposed to COVID-19 and suffered from increased adverse mental health outcomes as a result of their position in the first line of defense. By using a phenomenological qualitative
study, 31 participants were interviewed to understand if social distancing affected their lives in any significant way. The results of this study determined that social distancing occurred within families and friends, which was difficult for a population that
heavily relied and needed support during this challenging time. Additionally, social distancing occurred in the workplace and that affected first responder’s ability to work effectively in their occupation and with patients. Both these situations caused anxiety
and stress in first responders. Overall, distancing may be contributing to some of the poor mental health outcomes that are currently researched in first responders during the COVID-19 pandemic. © 2020 Taylor & Francis Group, LLC. |
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Zuo, T, Zhan, et al |
Gastroenterology |
Clinical data| Données cliniques |
Investigated changes in the fecal fungal microbiomes (mycobiome) of patients with SARS-CoV-2 infection during hospitalization
and on recovery. Patients with COVID-19 had significant alterations in their fecal mycobiomes compared with controls, characterized by enrichment of Candia albicans and a highly heterogeneous mycobiome configuration, at time of hospitalization. Although fecal
mycobiomes of 22 patients with COVID-19 did not differ significantly from those of controls during times of hospitalization, 8 of 30 patients with COVID-19 had continued significant differences in fecal mycobiome composition, through the last sample collected.
The diversity of the fecal mycobiome of the last sample collected from patients with COVID-19 was 2.5-fold higher than that of controls. Samples collected at all timepoints from patients with COVID-19 had increased proportions of opportunistic fungal pathogens,
Candida albicans, Candida auris, and Aspergillus flavus compared with controls. Two respiratory-associated fungal pathogens, A. flavus and Aspergillus niger, were detected in fecal samples from a subset of patients with COVID-19, even after clearance of SARS-CoV-2
from nasopharyngeal samples and resolution of respiratory symptoms. |
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Nat Med |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Using a deterministic SEIR (susceptible, exposed, infectious and recovered) compartmental framework to model possible
trajectories of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections we find that universal mask use could save an additional 129,574 (85,284-170,867) lives across the United States from September 22, 2020 through the end of February 2021. |
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32935873; Invited Review: The spectrum of neuropathology in COVID-19 |
Al-Sarraj, S, Troakes, et al |
Neuropathology and applied neurobiology |
Review Literature| Revue de littérature |
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Alves, GS, Casali, et al |
Frontiers in Psychiatry |
Review Literature| Revue de littérature |
SR: MEDLINE, LILACS, Cochrane and SCOPUS were searched for articles between January 2010 to March 2020. Evidence from
the last few years suggest that low-cost techniques, tailored to the dyad well-being, with increasing use of technology through friendly online platforms and application robots, can be an alternative to conventional assistance during COVID-19 Pandemic.
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Alzahrani, FA, Saadeldin, et al |
Stem Cells International |
Review Literature| Revue de littérature |
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Amjad, M, Chavez, et al |
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Review Literature| Revue de littérature |
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Bailey, D, Konforte, et al |
Clinical biochemistry |
Review Literature| Revue de littérature |
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Hydroxychloroquine: A comprehensive review and its controversial role in coronavirus disease
2019 |
Bansal, P, Goyal, et al |
Ann Med |
Review Literature| Revue de littérature |
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Nutrition Support During Prone Positioning: An Old Technique Reawakened by COVID-19 |
Behrens, S, Kozeniecki, et al |
Nutr Clin Pract |
Review Literature| Revue de littérature |
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State of Science: The future of work - Ergonomics and Human Factors contributions to the field |
Bentley, T, Green, et al |
Ergonomics |
Review Literature| Revue de littérature |
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Virtual
internships and work-integrated learning in hospitality and tourism in a post-COVID-19 world |
Bilsland, C, Nagy, et al |
International Journal of Work-Integrated Learning |
Review Literature| Revue de littérature |
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Bolt, SR, van der Steen, et al |
International journal of nursing studies |
Review Literature| Revue de littérature |
ScR: searched the bibliographic databases of PubMed, CINAHL and PsycINFO for academic publications. We searched for
grey literature using the search engine Google. Moreover, we included relevant letters and editorials, guidelines, web articles and policy papers. There is a particular need for grief and bereavement support and we must acknowledge grief and moral distress
among nursing staff. This review exposes practice and knowledge gaps in the response to COVID-19 that reflect the longstanding neglect and weaknesses of palliative care in the long-term care sector. Nursing leadership is needed to safeguard the quality of
palliative care, interprofessional collaboration and peer support among nursing staff. |
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Brisse, M, Vrba, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Brouwers, L, Herrmann, et al |
Social Sciences |
Review Literature| Revue de littérature |
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Suicide and the Elderly During the COVID-19 Pandemic: An Overview of Different Suicide Theories |
Chou, HC, Tzeng, et al |
Prim Care Companion CNS Disord |
Review Literature| Revue de littérature |
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Da Silva Terres, M, Rohden, et al |
Revista Brasileira de Marketing |
Review Literature| Revue de littérature |
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Ding, Chunyan |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
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Progress and Pitfalls in the Quest for Effective SARS-CoV-2 (COVID-19) Vaccines |
Flanagan, KL, Best, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Franca, RA, Ugga, et al |
Apmis |
Review Literature| Revue de littérature |
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Gao, Q, Liu, et al |
Journal of the Nepal Medical Association |
Review Literature| Revue de littérature |
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Gilbert, C, Siepser, et al |
Psychology of Sexual Orientation and Gender Diversity |
Review Literature| Revue de littérature |
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Gupta, P |
Indian Journal of Tuberculosis |
Review Literature| Revue de littérature |
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Hardy, M, Douxfils, et al |
Annales de Biologie Clinique |
Review Literature| Revue de littérature |
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Hasan, MA, Carmel Mary Esther, et al |
Surface Engineering |
Review Literature| Revue de littérature |
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The worldwide clinical trial research response to the COVID-19 pandemic - the first 100 days |
Hemkens, LG, Janiaud, et al |
F1000Research |
Review Literature| Revue de littérature |
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Hörcher, Daniel, Singh, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
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Dental patient management in the context of the covid-19 pandemic: Current literature mini-review |
Horzov, L, Goncharuk-Khomyn, et al |
Open Public Health Journal |
Review Literature| Revue de littérature |
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Iacobucci, G |
Bmj |
Review Literature| Revue de littérature |
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An Overview of the Crystallized Structures of the SARS-CoV-2 |
Ionescu, MI |
Protein J |
Review Literature| Revue de littérature |
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33040021; Classification of aerosol-generating procedures: A rapid systematic review |
Jackson, T, Deibert, et al |
BMJ Open Respiratory Research |
Review Literature| Revue de littérature |
SR: systematically searched two medical databases (medline, cochrane central) and one public search engine (google)
in march and april 2020. There is sufficient evidence of agreement across different international guidelines to classify certain procedure groups as aerosol generating. |
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Prevalence of underlying diseases in died cases of COVID-19: A systematic review and meta-analysis |
Javanmardi, F, Keshavarzi, et al |
PLoS One |
Review Literature| Revue de littérature |
SR-MA: International database including PubMed, Scopus, Web of Science, Cochrane and google scholar were searched for
relevant studies up to 1 June. In summary, underlying disease have a critical role in poor outcomes, severity of disease and high mortality rate of COVID-19 cases. Patients with hypertension, cardiovascular disease and diabetes should be carefully monitored
and be aware of health protocols. |
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Kefale, B, Tegegne, et al |
Clinical and Applied Thrombosis/Hemostasis |
Review Literature| Revue de littérature |
SR-MA: PubMed, Cumulative Index to Nursing and Allied Health Literature, EMBASE, and Cochrane library were searched.
The pooled prevalence of thrombotic events in COVID-19 patients was 33%. The prevalence of thrombotic event is variables on the basis of study design and study centers. Several risk factors such as, elevated D-dimer, hospitalized in the intensive care unit
and being under mechanical ventilation, were the most frequently reported risk factors identified. Therefore, healthcare professionals should consider these risk factors to optimally manage thromboembolism in COVID-19 patients.
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Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma |
Kempuraj, D, Thangavel, et al |
Biofactors |
Review Literature| Revue de littérature |
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A systematic review of non-contact sensing for developing a platform to contain covid-19 |
Khan, MB, Zhang, et al |
Micromachines |
Review Literature| Revue de littérature |
SR: This systematic review presents the data collection technology, data preprocessing, data preparation, features
extraction, classification algorithms and performance achieved by the various non-contact sensing platforms. This study proposes a non-contact sensing platform for the early diagnosis of COVID-19 symptoms and monitoring of the human activities and health during
the isolation or quarantine period. |
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Kichloo, A, Dettloff, et al |
Clinical and Applied Thrombosis/Hemostasis |
Review Literature| Revue de littérature |
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Macrophages in diabetes mellitus (DM) and COVID-19: do they trigger DM? |
Kloc, M, Ghobrial, et al |
Journal of Diabetes and Metabolic Disorders |
Review Literature| Revue de littérature |
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Optimizing Effective Communication While Wearing a Mask During the COVID-19 Pandemic |
Knollman-Porter, K, Burshnic, et al |
J Gerontol Nurs |
Review Literature| Revue de littérature |
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Kumar, V |
International immunopharmacology |
Review Literature| Revue de littérature |
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Kwee, TC, Kwee, et al |
Radiographics |
Review Literature| Revue de littérature |
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Antivirals for COVID-19 in Solid Organ Transplant Recipients |
Laracy, JC, Verna, et al |
Current Transplantation Reports |
Review Literature| Revue de littérature |
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Levi, Adi, Kessler, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
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Li, Z, Niu, et al |
Cell Prolif |
Review Literature| Revue de littérature |
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Seeing the invisible hand: Underlying effects of COVID-19 on tourists’ behavioral patterns |
Li, Z, Zhang, et al |
Journal of Destination Marketing and Management |
Review Literature| Revue de littérature |
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Liu, M |
Side Effects of Drugs Annual |
Review Literature| Revue de littérature |
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Loker, A |
Journal of Agricultural and Food Industrial Organization |
Review Literature| Revue de littérature |
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MacLean, A, Ashton, et al |
BMJ Paediatrics Open |
Review Literature| Revue de littérature |
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Majumder, J, Das, et al |
Asian Journal of Chemistry |
Review Literature| Revue de littérature |
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Impact of COVID-19 on Medium-Term Export Prospects for Soybeans, Corn, Beef, Pork, and Poultry |
Mallory, ML |
Applied Economic Perspectives and Policy |
Review Literature| Revue de littérature |
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Mechanick, JI, Carbone, et al |
JPEN J Parenter Enteral Nutr |
Review Literature| Revue de littérature |
ScR: In conclusion, this ASPEN scoping review has identified multiple critical areas for urgent nutrition research,
particularly using RCT design, to improve nutritional care for patients before, during, and after COVID-19.
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Mostafa, T |
Sexual Medicine Reviews |
Review Literature| Revue de littérature |
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Preprint manuscripts and servers in the era of coronavirus disease 2019 |
Nabavi Nouri, S, Cohen, et al |
J Eval Clin Pract |
Review Literature| Revue de littérature |
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Cyber Security Threats in the Era of COVID-19 Pandemic: A Case Study of Nigeria System |
Omodunbi, BA, O |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
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Challenges and future directions of potential natural products leads against 2019-nCoV outbreak |
Ospanov, M, León, et al |
Current Plant Biology |
Review Literature| Revue de littérature |
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Parikh, P, Kumar, et al |
Medicinal Plants |
Review Literature| Revue de littérature |
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Emotional, Behavioral, and Psychological Impact of the COVID-19 Pandemic |
Pedrosa, AL, Bitencourt, et al |
Frontiers in Psychology |
Review Literature| Revue de littérature |
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Thermal comfort applied in hospital environments: A literature review |
Pereira, PFDC, Broday, et al |
Applied Sciences (Switzerland) |
Review Literature| Revue de littérature |
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Pirjani, R, Rabiei, et al |
International Journal of Fertility and Sterility |
Review Literature| Revue de littérature |
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Rahimi, A, Mirzazadeh, et al |
Genomics |
Review Literature| Revue de littérature |
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Sentiment Analysis of User Feedback on the HSE Contact Tracing App |
Rekanar, Kaavya, Buckley, et al |
Research Square prepub |
Review Literature| Revue de littérature |
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COVID-19 impacts and recovery strategies: The case of the hospitality industry in Spain |
Rodríguez-Antón, JM, Alonso-Almeida, et al |
Sustainability (Switzerland) |
Review Literature| Revue de littérature |
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Roshandel, MR, Nateqi, et al |
Cellular and molecular biology (Noisy-le-Grand, France) |
Review Literature| Revue de littérature |
SR-MA: performed a literature search of clinical trials, cohorts, and case series using PubMed/MEDLINE, Google Scholar,
and Cochrane library, and downloadable database of CDC. Our review concludes that not only the SARS-CoV-2 can be excreted in the urine in eight percent of patients but also its incidence may have associations with the severity of the systemic disease, ICU
admission, and fatality rates. Moreover, the findings in our review suggest that a larger population size may reveal more positive urinary cases possibly by minimizing biases. |
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32920079; Magnetic particle targeting for diagnosis and therapy of lung cancers |
Saadat, M, Manshadi, et al |
Journal of Controlled Release |
Review Literature| Revue de littérature |
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Working remotely: Innovative allied health placements in response to COVID-19 |
Salter, C, Oates, et al |
International Journal of Work-Integrated Learning |
Review Literature| Revue de littérature |
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Preparing for an Era of Episode-Based Care in Total Joint Arthroplasty |
Sambare, TD, Bozic, et al |
Journal of Arthroplasty |
Review Literature| Revue de littérature |
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ACE2 in the Era of SARS-CoV-2: Controversies and Novel Perspectives |
Saponaro, F, Rutigliano, et al |
Frontiers in Molecular Biosciences |
Review Literature| Revue de littérature |
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The Role of Type I Interferons in the Pathogenesis and Treatment of COVID-19 |
Schreiber, G |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Schulman, S, Hu, et al |
Thromb Haemost |
Review Literature| Revue de littérature |
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The burden of type 2 diabetes pre-and during the COVID-19 pandemic – a review |
Sciberras, J, Camilleri, et al |
Journal of Diabetes and Metabolic Disorders |
Review Literature| Revue de littérature |
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Scott, M, Unsworth, et al |
SAGE Open Nursing |
Review Literature| Revue de littérature |
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Simonetti, A, Pais, et al |
Frontiers in Psychiatry |
Review Literature| Revue de littérature |
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33046185; The importance of transparency in building simulation models of the COVID-19 spread |
Sørup, CM |
Ugeskrift for laeger |
Review Literature| Revue de littérature |
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Utility of Proteomics in Emerging and Re-Emerging Infectious Diseases Caused by RNA Viruses |
Sperk, M, van Domselaar, et al |
J Proteome Res |
Review Literature| Revue de littérature |
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Sultan, K, Mone, et al |
World Journal of Gastroenterology |
Review Literature| Revue de littérature |
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Surber, RS |
Ethics and Information Technology |
Review Literature| Revue de littérature |
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Artificial lungs--Where are we going with the lung replacement therapy? |
Swol, J, Shigemura, et al |
Artif Organs |
Review Literature| Revue de littérature |
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Taefehshokr, N, Taefehshokr, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Ayurveda and Allopathic Therapeutic Strategies in Coronavirus Pandemic Treatment 2020 |
Talwar, S, Sood, et al |
Current Pharmacology Reports |
Review Literature| Revue de littérature |
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Tandon, Medha, Mehta, et al |
Research Square prepub |
Review Literature| Revue de littérature |
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Coronavirus disease 2019 (COVID-19) and ageism: a narrative review of the literature |
Tarazona-Santabalbina, F, de la Cámara de las Heras, et al |
Revista Espanola de Geriatria y Gerontologia |
Review Literature| Revue de littérature |
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Tysiąc-Miśta, M, Bulanda, et al |
Med Pr |
Review Literature| Revue de littérature |
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Immunopathology of galectin-3: An increasingly promising target in COVID-19 |
Velpula, KK, Caniglia, et al |
F1000Research |
Review Literature| Revue de littérature |
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Wang, Y, Chen, et al |
J Med Virol |
Review Literature| Revue de littérature |
SR-MA: search of PubMed, Embase, Cochrane Library databases, medRxiv and bioRxiv for data published through Oct 12,
2020. In conclusion, these results suggest that ACEI/ARB medications should not be discontinued for hypertensive patients in the context of COVID-19 pandemic.
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Awake prone positioning for COVID-19 hypoxemic respiratory failure: A rapid review |
Weatherald, J, Solverson, et al |
Journal of critical care |
Review Literature| Revue de littérature |
Rapid Review: search was conducted on May 19, 2020 and was updated on August 7, 2020 with no restrictions on publication
language or date. Databases and grey literature sources searched included: MEDLINE (Ovid), PubMed, Trip PRO, Cochrane Library, LitCOVID, WHO COVID-19 Research Database, Centre for Evidence-Based Medicine (CEBM), National Institute for Health and Care Excellence
(NICE), medRxiv, BMJ Best Practice, Cambridge Coronavirus Free Access Collection, and Google Scholar. In summary, although awake prone positioning may be a promising therapy for patients with hypoxemic respiratory failure (including those with COVID-19), the
supporting evidence is limited to case reports and cohort studies. |
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Williams, Vijai, Dash, et al |
medRxiv |
Review Literature| Revue de littérature |
SR-MA: Articles published in PubMed, Web of Science, Scopus, Google Scholar, and WHO COVID-19 research database, CDC
database, and Cochrane COVID-19 study register between 1st December 2019 to 10th July 2020. Conclusion: Fever, gastrointestinal and mucocutaneous symptoms, cardiac dysfunction, shock, and hyperinflammation are common manifestations of PIMS-TS or MIS-C. The
short-term outcome is good with supportive intensive care and immunomodulatory treatment. |
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Wood, YI, Zegwaard, et al |
International Journal of Work-Integrated Learning |
Review Literature| Revue de littérature |
MA: a meta-analysis was conducted of these WIL models, to provide a complied synthesis of existing practice from within
the WIL field specifically focused on two books, the International Journal of Work-Integrated Learning, and three national WIL association conference publications. The trends and qualities that emerge from the meta-analysis of existing practice can inform
the redevelopment across the different modes of conventional, remote, virtual, and simulated WIL experiences.
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All Surfaces Are Not Equal in Contact Transmission of SARS-CoV-2 |
Xue, X, Ball, et al |
Matter |
Review Literature| Revue de littérature |
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Understanding the role of neutrophils in acute respiratory distress syndrome |
Yang, SC, Tsai, et al |
Biomedical Journal |
Review Literature| Revue de littérature |
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33038418; Targeting pivotal inflammatory pathways in COVID-19: A mechanistic review |
Yarmohammadi, A, Yarmohammadi, et al |
European journal of pharmacology |
Review Literature| Revue de littérature |
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Yi, ZM, Hu, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
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A study on the transformation of accounting based on new technologies: Evidence from korea |
Yoon, S |
Sustainability (Switzerland) |
Review Literature| Revue de littérature |
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Younger, DS |
Brain Pathol |
Review Literature| Revue de littérature |
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Zhou, Z, Price, et al |
Expert Opin Investig Drugs |
Review Literature| Revue de littérature |
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“COVID-19 risks among people who inject drugs in Puerto Rico” |
Abadie, R, Gelpi-Acosta, et al |
International Journal of Drug Policy |
Commentary/Editorial| Commentaire/Éditorial |
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The potential use of ABO blood group system for risk stratification of COVID-19 |
AbdelMassih, AF, Mahrous, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Abouleish, M, El-Keblawy, et al |
Current Topics in Medicinal Chemistry |
Commentary/Editorial| Commentaire/Éditorial |
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Judicious use of personal protective equipment to prevent the spread of COVID-19 in maternity
units |
Adam, S, Maswime, et al |
South African Journal of Obstetrics and Gynaecology |
Commentary/Editorial| Commentaire/Éditorial |
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Adekoya, OB, Oliyide, et al |
Resources Policy |
Commentary/Editorial| Commentaire/Éditorial |
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"Mask tinea": tinea faciei possibly potentiated by prolonged mask usage during the COVID-19 pandemic |
Agarwal, A, Hassanandani, et al |
Clin Exp Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Alacio García, RY |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Response to COVID-19 Pandemic: Where Do Public Libraries Stand? |
Alajmi, BM, Albudaiwi, et al |
Public Library Quarterly |
Commentary/Editorial| Commentaire/Éditorial |
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Alanson, ER, Alanson, et al |
International Journal of Work-Integrated Learning |
Commentary/Editorial| Commentaire/Éditorial |
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Practices of the state of emergency: Consequences of COVID-19 to the political system of Italy |
Alekseenkova, E |
Sovremennaya Evropa |
Commentary/Editorial| Commentaire/Éditorial |
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Amato, A, Cozzolino, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Anderson, PO |
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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University teaching and learning in a time of social distancing: A sociocultural perspective |
Ando, S |
Journal of Human Behavior in the Social Environment |
Commentary/Editorial| Commentaire/Éditorial |
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Andrews, J, Ramji, et al |
International Journal of Work-Integrated Learning |
Commentary/Editorial| Commentaire/Éditorial |
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Andrist, E, Clarke, et al |
Pediatric Critical Care Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Ángeles López-Cabarcos, M, López-Carballeira, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Angelini, S, Pinto, et al |
Frontiers in Endocrinology |
Commentary/Editorial| Commentaire/Éditorial |
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Angulo, E, Negrón, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Anile, A, Castiglione, et al |
Anesth Analg |
Commentary/Editorial| Commentaire/Éditorial |
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Leading through social distancing: The future of work, corporations and leadership from home |
Antonacopoulou, EP, Georgiadou, et al |
Gender, Work and Organization |
Commentary/Editorial| Commentaire/Éditorial |
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Anupama, S |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
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33053020; Temporal evolution of tomographic findings of pulmonary infection in COVID-19 |
Araujo-Filho, J, Sawamura, et al |
Einstein (Sao Paulo, Brazil) |
Commentary/Editorial| Commentaire/Éditorial |
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‘POLIDON’ Approach—A Novel Solution for the ENT & Skull Base Surgeons in COVID-19 era |
Arefin, MK, Arafat, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Touting traditional knowledge and herbal medicine to combat and prevent covid-19 |
Arokiaraj, S, Vincent, et al |
Current Pharmaceutical Biotechnology |
Commentary/Editorial| Commentaire/Éditorial |
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Arvesen, KB, Penninga, et al |
Forum for Nordic Dermato-Venerology |
Commentary/Editorial| Commentaire/Éditorial |
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Ashfaq, M, Bashir, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
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Ashton, J |
Journal of the Royal Society of Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Avila Hernandez, FM, De Los Santos Olivo, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Azevedo, R, Constantinescu, et al |
Ultraschall in der Medizin |
Commentary/Editorial| Commentaire/Éditorial |
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Azzolino, D, Cesari, et al |
Frontiers in Endocrinology |
Commentary/Editorial| Commentaire/Éditorial |
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Baig, AM |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
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Editing from the dungeons of the pandemic; an editor’s agonisingly painful battle with COVID-19 |
Bajwa, SJS |
Indian Journal of Anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Balaji, SM |
Annals of Maxillofacial Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Reactions to the Pandemic in Latin America and Brazil: Are Religions Essential Services? |
Bandeira, O, Carranza, et al |
International Journal of Latin American Religions |
Commentary/Editorial| Commentaire/Éditorial |
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“A Plague upon Your Howling”: art and culture in the viral emergency |
Banks, M, O’Connor, et al |
Cultural Trends |
Commentary/Editorial| Commentaire/Éditorial |
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Incidence of covid-19 pandemic in the colombian state economy |
Baquero Suárez, TM, Liñan Solorzano, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Barbieri, A, Robinson, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Barguil, Y, Chiaradia, et al |
Annales de Biologie Clinique |
Commentary/Editorial| Commentaire/Éditorial |
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Challenges faced by rohingya refugees in the covid-19 pandemic |
Barua, A, Karia, et al |
Annals of Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Bauer, B |
VOEB-Mitteilungen |
Commentary/Editorial| Commentaire/Éditorial |
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Interoperable medical data: the missing link for understanding COVID-19 |
Bauer, DC, Metke-Jimenez, et al |
Transbound Emerg Dis |
Commentary/Editorial| Commentaire/Éditorial |
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The organization of primary care teams from the COVID-19 pandemic |
Bayona Huguet, X |
Atencion Primaria Practica |
Commentary/Editorial| Commentaire/Éditorial |
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Beaune, C |
Politique Etrangere |
Commentary/Editorial| Commentaire/Éditorial |
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Belhadi, A, Kamble, et al |
Environ Manage |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus: The medical act from legal and human rights in colombia |
BeltrÁN De La Rosa, E, Araque Barboza, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Psychological effects of covid-19 and its measures in nepalese medical students |
Bhandari, A, Bhatta, et al |
Journal of the Nepal Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Bianco, C, Baselli, et al |
Liver Int |
Commentary/Editorial| Commentaire/Éditorial |
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Borrell, J |
Politique Etrangere |
Commentary/Editorial| Commentaire/Éditorial |
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Botta, Michela, Tsonas, et al |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Work-integrated learning placements and remote working: Experiential learning online |
Bowen, T |
International Journal of Work-Integrated Learning |
Commentary/Editorial| Commentaire/Éditorial |
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Brenna, OV, Torretta, et al |
International Journal of Immunopathology and Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Have a Heart: Addressing the Gradient of Social Determinants of Health During the COVID-19
Era |
Brewer, LC, Hayes, et al |
JACC: Case Reports |
Commentary/Editorial| Commentaire/Éditorial |
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Briant, S, Crowther, et al |
International Journal of Work-Integrated Learning |
Commentary/Editorial| Commentaire/Éditorial |
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Behavioral medicine challenges in the shadow of a global pandemic |
Brooks, AT, Allen, et al |
Transl Behav Med |
Commentary/Editorial| Commentaire/Éditorial |
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Brosseau, LM, Roy, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
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Mental health rescue effects of women's outdoor tourism: A role in COVID-19 recovery |
Buckley, R, Westaway, et al |
Annals of Tourism Research |
Commentary/Editorial| Commentaire/Éditorial |
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Surgery and emergency gastrointestinal endoscopy during the Covid-19 pandemic |
Bujanda, L, Arratibel, et al |
Gastroenterologia y hepatologia |
Commentary/Editorial| Commentaire/Éditorial |
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Burlacu, A, Artene, et al |
Clinical and Applied Thrombosis/Hemostasis |
Commentary/Editorial| Commentaire/Éditorial |
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Platform and data co-operatives amidst European pandemic citizenship |
Calzada, I |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Much ado about nothing: Paradoxes of immigrant regularization sprang from pandemic |
Campomori, F, Marchetti, et al |
Politiche Sociali |
Commentary/Editorial| Commentaire/Éditorial |
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Cañas, CA |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Carmody, C, Duffy, et al |
International Journal of Work-Integrated Learning |
Commentary/Editorial| Commentaire/Éditorial |
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Introduction to the special issue 'Reflections on the post COVID-19 World' |
Caruso, R, Kibris, et al |
Peace Economics, Peace Science and Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Challenges of health emergency in the face of research training |
Casanova Romero, I, Canquiz Rincon, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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The Italian response to the economic and health crises: a budgetary comparison |
Cepiku, D, Marchese, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
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Cevik, M, Kuppalli, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Çevikelli Yakut, ZA, Şakarcan, et al |
Journal of Research in Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
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Democratic interpretation of the colombian constitution in times of crisis (COVID-19 pandemic) |
Chacín Fuenmayor, R, Villa-Villa, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Chammas, D |
Journal of pain and symptom management |
Commentary/Editorial| Commentaire/Éditorial |
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Chan, HY |
Liverpool Law Review |
Commentary/Editorial| Commentaire/Éditorial |
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Chansanam, Wirapong, Suttipapa, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Transport-related experiences in China in response to the Coronavirus (COVID-19) |
Chen, Q, Pan, et al |
Transportation Research Interdisciplinary Perspectives |
Commentary/Editorial| Commentaire/Éditorial |
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Chene, G, Bouvet, et al |
European Journal of Obstetrics and Gynecology and Reproductive Biology |
Commentary/Editorial| Commentaire/Éditorial |
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Chithra, NK, Kandasamy, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Chong, S, Huang, et al |
Journal of Applied Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Conflict in the Time of (Post-) Corona: Some Assessments from Behavioral Economics |
Chowdhury, SM |
Peace Economics, Peace Science and Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Recent advances in technology, strategy and application of sustainable energy systems |
Chu, W, Calise, et al |
Energies |
Commentary/Editorial| Commentaire/Éditorial |
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Assessing clinical competency without patients during COVID-19 pandemic |
Chung, PHY, Tsang, et al |
Surgical Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Ciner, C |
Finance Research Letters |
Commentary/Editorial| Commentaire/Éditorial |
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Claytor, B |
Aesthet Surg J |
Commentary/Editorial| Commentaire/Éditorial |
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Cohen, E |
Politique Etrangere |
Commentary/Editorial| Commentaire/Éditorial |
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Cohen, EL |
Science Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Collins, T, Akselrod, et al |
Annals of Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Colpitts, BDF, Smith, et al |
Interactive Technology and Smart Education |
Commentary/Editorial| Commentaire/Éditorial |
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Cooke, FL, Dickmann, et al |
International Journal of Human Resource Management |
Commentary/Editorial| Commentaire/Éditorial |
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Governance and life project: (re) thinking the post-pandemic society |
Córdova Jaimes, E |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Córdova Jaimes, E |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Cota-Sánchez, JH |
Revista Brasileira de Botanica |
Commentary/Editorial| Commentaire/Éditorial |
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Coudeville, L, Gomez, et al |
Vaccine |
Commentary/Editorial| Commentaire/Éditorial |
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Crawford, M |
Biomedical instrumentation & technology |
Commentary/Editorial| Commentaire/Éditorial |
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Crimi, C, Carlucci, et al |
Pulmonology |
Commentary/Editorial| Commentaire/Éditorial |
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Croasdell, G |
Drugs of the Future |
Commentary/Editorial| Commentaire/Éditorial |
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da Silva, MAD, Walmsley, et al |
Dental update |
Commentary/Editorial| Commentaire/Éditorial |
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Damiani, E, Carsetti, et al |
Ann Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
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Danchin, M |
Australian journal of general practice |
Commentary/Editorial| Commentaire/Éditorial |
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32892181; COVID-19 in obstetrics 2020: The experience at a New York City medical center |
Dayal, AK, Razavi, et al |
Journal of perinatal medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Labour Migrants During the Pandemic: A Comparative Perspective |
de Haan, A |
Indian Journal of Labour Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Reshaping work-integrated learning in a post-COVID-19 world of work |
Dean, BA, Campbell, et al |
International Journal of Work-Integrated Learning |
Commentary/Editorial| Commentaire/Éditorial |
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Defarges, PM |
Politique Etrangere |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and systemic sclerosis: Rising to the challenge of a pandemic |
Denton, CP, Campochiaro, et al |
Journal of Scleroderma and Related Disorders |
Commentary/Editorial| Commentaire/Éditorial |
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Di Martino, D, Chiaffarino, et al |
Int J Gynaecol Obstet |
Commentary/Editorial| Commentaire/Éditorial |
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Diaconu, CC |
Archives of the Balkan Medical Union |
Commentary/Editorial| Commentaire/Éditorial |
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Diop, Samba, Asongu, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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33034574; COVID-19 pnömonisi ile enfekte genç bir erkekte pulmoner emboli |
Doğan, AC, Güner, et al |
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 paediatric caries management: The Newcastle ‘Hall’ Approach |
Donnell, CC, Dixon, et al |
Dental update |
Commentary/Editorial| Commentaire/Éditorial |
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Doraiswamy, S, Mamtani, et al |
Age Ageing |
Commentary/Editorial| Commentaire/Éditorial |
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Anti-inflammatory substances from onions could be an option for treatment of COVID-19—a hypothesis |
Dorsch, W, Ring, et al |
Allergo Journal International |
Commentary/Editorial| Commentaire/Éditorial |
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The Data Science of COVID-19 Spread: Some Troubling Current and Future Trends |
Douglass, RW, Scherer, et al |
Peace Economics, Peace Science and Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Aftermath of COVID-19: Wither postgraduate teaching and research? |
Dubey, PK, Ranjan, et al |
Indian Journal of Anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Dwyer, PD, Minnegal, et al |
Asia and the Pacific Policy Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 pandemic highlights need for us policies that increase supply chain resilience |
Dyatkin, B |
MRS Bulletin |
Commentary/Editorial| Commentaire/Éditorial |
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Eaton, J, Rahman, et al |
Eastern Mediterranean Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Eboibi, FE, Robert, et al |
Commonwealth Law Bulletin |
Commentary/Editorial| Commentaire/Éditorial |
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Editors, Plos One |
PloS one |
Commentary/Editorial| Commentaire/Éditorial |
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Ekman, A |
Politique Etrangere |
Commentary/Editorial| Commentaire/Éditorial |
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Managing Patients With ST-Elevation Myocardial Infarction at the Epicenter of the COVID-19
Pandemic |
Elbaum, L, Rashed, et al |
Current problems in cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Egyptian budgetary responses to COVID-19 and their social and economic consequences |
Elkhashen, EM, Sarhan, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Commentary/Editorial| Commentaire/Éditorial |
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Entin, M |
Sovremennaya Evropa |
Commentary/Editorial| Commentaire/Éditorial |
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Espinosa Castro, T |
Intercultural Education |
Commentary/Editorial| Commentaire/Éditorial |
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Virtual distinguished lectures during COVID-19 [Distinguished Lecturers] |
Esselle, KP |
IEEE Antennas and Propagation Magazine |
Commentary/Editorial| Commentaire/Éditorial |
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Evans, G |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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Some health departments,
hospitals ignore CDC COVID-19 testing changes |
Evans, G |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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OSHA fines facility $28,000
for failure to protect workers from COVID-19 |
Evans, G |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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Ezirigwe, J, Ojike, et al |
Law and Development Review |
Commentary/Editorial| Commentaire/Éditorial |
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Faggiano, A, Carugo, et al |
Int J Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
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Felbermayr, G, Görg, et al |
Perspektiven der Wirtschaftspolitik |
Commentary/Editorial| Commentaire/Éditorial |
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Feldman, Mitra, Vernaeve, et al |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
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How 'Monetization' Really Works—Examples from Nations’ Policy Responses to COVID-19 |
Felipe, Jesus, Fullwiler, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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“Trust me, I’m your neighbour” How to improve epidemic risk containment through community trust |
Felletti, S |
Mind and Society |
Commentary/Editorial| Commentaire/Éditorial |
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American chemical society (ACS) 260thnational meeting and exposition |
Fernández-Llamazares, AI |
Drugs of the Future |
Commentary/Editorial| Commentaire/Éditorial |
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Should We Be Worried About Clostridioides difficile During the SARS-CoV2 Pandemic? |
Ferreira, EDO, Penna, et al |
Frontiers in Microbiology |
Commentary/Editorial| Commentaire/Éditorial |
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Management of Breast Cancer Patients during the COVID-19 Pandemic in Northern Italy |
Ferro, A, Cristofolini, et al |
Breast Care |
Commentary/Editorial| Commentaire/Éditorial |
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Fiorina, L, Younsi, et al |
Annales de Cardiologie et d'Angeiologie |
Commentary/Editorial| Commentaire/Éditorial |
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33043877; Foreword to special COVID-19 edition for Irish Journal of Psychological Medicine |
Flannery, W |
Irish Journal of Psychological Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Forde, JJ, Goldberg, et al |
Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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The Impact of the Covid-19 Pandemic on Firms’ Organizational Designs |
Foss, NJ |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Diabetes begünstigt Nierenversagen bei COVID-19-Patienten: Corona-Pandemie -- Autor: E. Fritschka |
Fritschka, E |
MMW-Fortschritte der Medizin |
Commentary/Editorial| Commentaire/Éditorial |
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Fuentes, R, Galeotti, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Type I IFN-dependent antibody response at the basis of sex dimorphism in the outcome of COVID-19 |
Gabriele, L, Fragale, et al |
Cytokine and Growth Factor Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Innovating
to mitigate adverse financial implications of covid-19's effects on higher education |
Gaeta, C |
Journal of health care finance |
Commentary/Editorial| Commentaire/Éditorial |
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Gaillard, N |
Politique Etrangere |
Commentary/Editorial| Commentaire/Éditorial |
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Social doctrine, justice and peace in times of pandemic. The case of Colombia and el Salvador |
Gálvez Valega, JA, Vega Lugo, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Gandhi, M, Rutherford, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
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García Otero, R, Hernández Palma, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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García-Peñalvo, FJ, Casado-Lumbreras, et al |
Applied Sciences (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Gargaglioni, LH, Marques, et al |
J Appl Physiol (1985) |
Commentary/Editorial| Commentaire/Éditorial |
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Mental health: The forgotten aspect of the COVID-19 pandemic |
Garrusi, B, Amirkafi, et al |
Eastern Mediterranean Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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33052791; COVID-19: pressure ulcers, pain and the cytokine storm |
Gefen, A, Ousey, et al |
Journal of wound care |
Commentary/Editorial| Commentaire/Éditorial |
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Marshall McLuhan and the therapeutic importance of the telephone |
Geller, JD |
Counselling Psychology Quarterly |
Commentary/Editorial| Commentaire/Éditorial |
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Glasmacher, SA, Larraz, et al |
Journal of neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Goessler, KF, Nicoletti, et al |
Obesity |
Commentary/Editorial| Commentaire/Éditorial |
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Supporting individuals with Autism Spectrum Disorder in medical settings during COVID-19 |
Goh, TJ, Lim, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Gomart, T |
Politique Etrangere |
Commentary/Editorial| Commentaire/Éditorial |
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Gomella, LG |
The Canadian journal of urology |
Commentary/Editorial| Commentaire/Éditorial |
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Gómez de Pablos Romero, M, Sánchez Martín, et al |
Pediatria Integral |
Commentary/Editorial| Commentaire/Éditorial |
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Gómez-Ochoa, SA, Van Poll, et al |
Case Reports in Women's Health |
Commentary/Editorial| Commentaire/Éditorial |
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Confluence of obesity and MAFLD during Covid-19 pandemic in a developing country |
Gonzáles Yovera, JG, Concepción-Zavaleta, et al |
Endocrinology, Diabetes and Metabolism |
Commentary/Editorial| Commentaire/Éditorial |
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González, VL |
Textiles Panamericanos |
Commentary/Editorial| Commentaire/Éditorial |
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Gooding, R, Myers, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
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Gopalkrishnan, M, Krishna, et al |
Journal of the Indian Institute of Science |
Commentary/Editorial| Commentaire/Éditorial |
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Górski, A, Borysowski, et al |
Pathogens |
Commentary/Editorial| Commentaire/Éditorial |
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Götz, FM, Gvirtz, et al |
American Psychologist |
Commentary/Editorial| Commentaire/Éditorial |
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33034891; Erratum: Unterbrochene Übertragungskette bei pädiatrischem COVID19-Fall |
Grauthoff, S |
Klinische Padiatrie |
Commentary/Editorial| Commentaire/Éditorial |
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From the editors COVID-19: Learning to hope and hoping to learn |
Greenberg, D, Hibbert, et al |
Academy of Management Learning and Education |
Commentary/Editorial| Commentaire/Éditorial |
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Greene, A |
European Human Rights Law Review |
Commentary/Editorial| Commentaire/Éditorial |
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Consequences of COVID-19 for cancer care - a CRUK perspective |
Greenwood, E, Swanton, et al |
Nat Rev Clin Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Guedes, IsabellaA, Costa, et al |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
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Guetto, R, Vignoli, et al |
European Societies |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in children: Considerations for returning to school |
Guimarães, AC, Mau, et al |
Brazilian Journal of Otorhinolaryngology |
Commentary/Editorial| Commentaire/Éditorial |
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Gupta, T, Ghosh-Laskar, et al |
Oral oncology |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Related Cerebrovascular Thromboembolic Complications in Three Young Patients |
Haroon, KH, Muhammad, et al |
Case Reports in Neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Commentary: Assessing the Global Impact of the Covid-19 Pandemic on Prison Populations |
Heard, C |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
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32965790; Hot Off the Press: SGEM#299—Learning to Test for COVID-19 |
Heitz, C, Morgenstern, et al |
Academic Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Hekimian, G, Frere, et al |
Annales de Cardiologie et d'Angeiologie |
Commentary/Editorial| Commentaire/Éditorial |
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Digital era in times of pandemic: Education, color, knowledge and communication |
Hernández, J, Torres Ardila, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Hidayat, S, Halid, et al |
Journal of Engineering and Technological Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 pandemic: Early implications for north european manufacturing and logistics |
Hilmola, OP, Lähdeaho, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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33046925; Emergency management at the health and security interface |
Hoile, R |
Revue scientifique et technique (International Office of Epizootics) |
Commentary/Editorial| Commentaire/Éditorial |
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Hole, R, Stainton, et al |
Child and Youth Services |
Commentary/Editorial| Commentaire/Éditorial |
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GoodWIL
placements: How COVID-19 shifts the conversation about unpaid placements |
Hoskyn, K, Eady, et al |
International Journal of Work-Integrated Learning |
Commentary/Editorial| Commentaire/Éditorial |
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La coopération sanitaire internationale à l’épreuve du
COVID-19 |
Houssin, D |
Politique Etrangere |
Commentary/Editorial| Commentaire/Éditorial |
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Grand Challenges, Covid-19 and the Future of Organizational Scholarship |
Howard-Grenville, J |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Importance of Flow for Lonely Nursing Home Residents During the COVID-19 Pandemic |
Huang, FH, Chang, et al |
J Gerontol Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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All-of-government response to the COVID-19 pandemic: The case of Vietnam |
Huynh, D, Tosun, et al |
Public Administration and Development |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Government shelves plans to invest £100bn in mass testing |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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33043325; Guest Editorial: COVID-19 and the risk of delayed diagnosis of oral cancer |
Ianculovici, C, Kaplan, et al |
Quintessence international (Berlin, Germany : 1985) |
Commentary/Editorial| Commentaire/Éditorial |
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Ikewaki, N, Iwasaki, et al |
Journal of Diabetes and Metabolic Disorders |
Commentary/Editorial| Commentaire/Éditorial |
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Inciarte González, A, Paredes-Chacín, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Iribarren, GF |
Textiles Panamericanos |
Commentary/Editorial| Commentaire/Éditorial |
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Jablonski, BBR, Casnovsky, et al |
Applied Economic Perspectives and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Sex differences in COVID-19 course and outcome: progesterone should not be neglected |
Jakovac, H |
J Appl Physiol (1985) |
Commentary/Editorial| Commentaire/Éditorial |
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Jevitt, CM |
Child and Youth Services |
Commentary/Editorial| Commentaire/Éditorial |
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Toward a Health Silk Road: China's Proposal for Global Health Cooperation |
Jiahan, C |
China Quarterly of International Strategic Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Kampf, G |
Hygiene + Medizin |
Commentary/Editorial| Commentaire/Éditorial |
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Kamran, M, Jafri, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Commentary/Editorial| Commentaire/Éditorial |
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33021326; Tidiga erfarenheter av steroidbehandling vid covid-19 |
Kan, B, Ahl, et al |
Lakartidningen |
Commentary/Editorial| Commentaire/Éditorial |
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Suicides cases among nurses in India due to COVID-19 and possible prevention strategies |
Kapilan, N |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Kárason, S, Runólfsdóttir, et al |
Laeknabladid |
Commentary/Editorial| Commentaire/Éditorial |
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Karnama, A, Vinuesa, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Kassem, DH, Kamal, et al |
Frontiers in Cell and Developmental Biology |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 crises: Global economic shocks vs Pakistan economic shocks |
Katper, NK, Tunio, et al |
Advances in Science, Technology and Engineering Systems |
Commentary/Editorial| Commentaire/Éditorial |
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Kault, D |
Med J Aust |
Commentary/Editorial| Commentaire/Éditorial |
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Two institutional responses to work-integrated learning in a time of COVID-19: Canada
and Australia |
Kay, J, McRae, et al |
International Journal of Work-Integrated Learning |
Commentary/Editorial| Commentaire/Éditorial |
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Kheiralla, OAM, Tajaldeen, et al |
European Journal of Radiology Open |
Commentary/Editorial| Commentaire/Éditorial |
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Blockade of an innate immune amplifier to fight immune hyperactivation in COVID-19? |
Kiemer, AK |
EBioMedicine |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19-Pandemie
– Überlegungen zum Führungsverhalten in Einrichtungen des Gesundheitswesens |
Kienbaum, T |
Hygiene + Medizin |
Commentary/Editorial| Commentaire/Éditorial |
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Author's reply to heart transplantation to fulminant myocarditis during COVID-19 outbreak |
Kim, IC, Hwang, et al |
Korean Circulation Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Products of oxidative guanine damage form base pairs with guanine |
Kino, K, Kawada, et al |
International Journal of Molecular Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Klinova, M |
Sovremennaya Evropa |
Commentary/Editorial| Commentaire/Éditorial |
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Kolesnikova, M |
Sovremennaya Evropa |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 and its impact on informal sector workers: a case study of Thailand |
Komin, W, Thepparp, et al |
Asia Pacific Journal of Social Work and Development |
Commentary/Editorial| Commentaire/Éditorial |
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Kronenfeld, JP, Penedo, et al |
Transl Behav Med |
Commentary/Editorial| Commentaire/Éditorial |
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Kufel, T, Kufel, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Lam, K, McClelland, et al |
Med J Aust |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7581497; In reply to: "A COVID-19 screening tool for oncology telephone triage" |
Lasagna, A, Monaco, et al |
Support Care Cancer |
Commentary/Editorial| Commentaire/Éditorial |
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Laufer, M |
Interciencia |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 pandemic and the prospects of education in South Africa |
Le Grange, L |
Prospects |
Commentary/Editorial| Commentaire/Éditorial |
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Leal Orozco, G |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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The race to make COVID antibody therapies cheaper and more potent |
Ledford, H |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Lee, D, Kirkpatrick, et al |
Textiles Panamericanos |
Commentary/Editorial| Commentaire/Éditorial |
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The Role of COVID-19 in Transitioning to a Better Pediatric Payment Model |
Lee, MA, Sprecher, et al |
Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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Leitmeyer, K, Felton, et al |
International journal of pediatric otorhinolaryngology |
Commentary/Editorial| Commentaire/Éditorial |
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Li Marzi, V, Campi, et al |
Actas Urologicas Espanolas |
Commentary/Editorial| Commentaire/Éditorial |
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Li, C, Tang, et al |
Risk Management and Healthcare Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Precautions in dentistry against the outbreak of corona virus disease 2019 |
Li, G, Chang, et al |
Journal of Infection and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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The Danger of Sedentary Lifestyle in Diabetic and Obese People During the COVID-19 Pandemic |
Lim, MA, Pranata, et al |
Clinical Medicine Insights: Endocrinology and Diabetes |
Commentary/Editorial| Commentaire/Éditorial |
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Personal Protective Equipment-Conserving Chest Radiography Setting During the COVID-19
Pandemic |
Lin, HJ, Hsu, et al |
Ann Emerg Med |
Commentary/Editorial| Commentaire/Éditorial |
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Beyond pandemic management: How WHO can address post-COVID-19 futures |
Lin, V |
Global Social Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Lipscomb, AE, Ashley, et al |
Smith College Studies in Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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Lipworth, B, Chan, et al |
Ann Allergy Asthma Immunol |
Commentary/Editorial| Commentaire/Éditorial |
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33035666; Virus-, host-, immune-based targets for COVID-19 therapy |
Liu, W, Zhu, et al |
Drug discovery today |
Commentary/Editorial| Commentaire/Éditorial |
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33047544; How COVID-19 has Been Transforming the Notion of Care |
López López, MV |
Investigacion y educacion en enfermeria |
Commentary/Editorial| Commentaire/Éditorial |
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32549118; The role of speech in the transmission of SARSCoV-2: recommendations for confined spaces |
López Olmedo, N, Barrientos-Gutiérrez, et al |
Salud publica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Social economy and covid-19: Contributions and perspectives in colombia |
Lora Ochoa, C, Anaya Narváez, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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33051193; Clinical research disruption in the post-COVID-19 era: will the pandemic lead to
change? |
Lorusso, D, Ray-Coquard, et al |
ESMO open |
Commentary/Editorial| Commentaire/Éditorial |
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Luiz, TDSC, Silva Filho, et al |
Revista Brasileira de terapia intensiva |
Commentary/Editorial| Commentaire/Éditorial |
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Academic Library Services during COVID-19: The Experience of CUHK Library |
Ma, LFH |
International Information and Library Review |
Commentary/Editorial| Commentaire/Éditorial |
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Splendid Isolation: A practical guide to the use of rubber dam part 2 |
Mackenzie, L, Bonsor, et al |
Dental update |
Commentary/Editorial| Commentaire/Éditorial |
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A novel distance measure for intuitionistic fuzzy sets with diverse applications |
Mahanta, J, Panda, et al |
International Journal of Intelligent Systems |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 mediated by basigin can affect male and female fertility |
Mahdian, S, Shahhoseini, et al |
International Journal of Fertility and Sterility |
Commentary/Editorial| Commentaire/Éditorial |
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Malta, M |
EClinicalMedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Marino, LV, Valla, et al |
Clinical Nutrition |
Commentary/Editorial| Commentaire/Éditorial |
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Markey, K, Ventura, et al |
J Nurs Manag |
Commentary/Editorial| Commentaire/Éditorial |
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Martínez-Lourido, E, Otero, et al |
Allergy |
Commentary/Editorial| Commentaire/Éditorial |
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Martin-Khan, M, Bail, et al |
Australasian journal on ageing |
Commentary/Editorial| Commentaire/Éditorial |
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Maslova, E, Savino, et al |
Sovremennaya Evropa |
Commentary/Editorial| Commentaire/Éditorial |
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Crisis and extended realities: remote presence in the time of COVID-19 |
Matthews, B, See, et al |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
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Airway Alert Bracelets: Enhancing Safety in the COVID-19 Era |
Matthews, LJ, OʼConnor, et al |
Anesth Analg |
Commentary/Editorial| Commentaire/Éditorial |
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McEachan, RRC, Dickerson, et al |
Wellcome Open Research |
Commentary/Editorial| Commentaire/Éditorial |
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McGregor, TB, Sener, et al |
Canadian journal of surgery.Journal canadien de chirurgie |
Commentary/Editorial| Commentaire/Éditorial |
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McMahon, JM |
Journal of health care finance |
Commentary/Editorial| Commentaire/Éditorial |
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Medina-Walpole, A |
J Gerontol Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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Rule of law and constitutional model against the 2020 pandemic |
Mendieta, D, Algarin Herrera, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Role of media in preventing gender-based violence and crimes during the COVID-19 pandemic |
Menon, V, Pattnaik, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19, the WHO Ottawa charter and the Red Cross-Red Crescent Movement |
Mercado, SP |
Global Social Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Milder, TY, Stocker, et al |
Drug Saf |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 in Ländern mit niedrigem oder mittlerem Einkommen: Das Beispiel Indien |
Mittal, N, Viswanath, et al |
Perspektiven der Wirtschaftspolitik |
Commentary/Editorial| Commentaire/Éditorial |
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Moraveji, S, Thaker, et al |
Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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Schooling in confinement: Natural experiment and stress test |
Moreno, JM, Gortazar, et al |
Profesorado |
Commentary/Editorial| Commentaire/Éditorial |
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In recovery mode: manufacturers try to bounce back after COVID-19 disruptions |
Moutray, C |
Business Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Quality of life and quality of environment in Czechia in the period of the COVID-19 pandemic |
Murgaš, F, Petrovič, et al |
Geograficky Casopis |
Commentary/Editorial| Commentaire/Éditorial |
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Murphy, AA, Karyczak, et al |
Community Ment Health J |
Commentary/Editorial| Commentaire/Éditorial |
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Nacul, MP, Azevedo, et al |
Revista do Colegio Brasileiro de Cirurgioes |
Commentary/Editorial| Commentaire/Éditorial |
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Approach of a Word2Vec Based Tourist Spot Collection Method Considering COVID-19 |
Nagai, Y, Saito, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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33026735; COVID-19: Dépister grâce à l’olfaction de chiens entraînés |
Nau, JY |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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Neff, LM |
Am J Clin Nutr |
Commentary/Editorial| Commentaire/Éditorial |
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Niedenthal, T |
Zeitschrift fur Phytotherapie |
Commentary/Editorial| Commentaire/Éditorial |
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Confronting the Covid-19 Epidemic and Control: Reports and Reflections from China |
Ning, W |
European Review |
Commentary/Editorial| Commentaire/Éditorial |
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Nkhata, SG, Ngoma, et al |
Human Ecology |
Commentary/Editorial| Commentaire/Éditorial |
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Odier, A |
Politique Etrangere |
Commentary/Editorial| Commentaire/Éditorial |
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Would Repurposing Minocycline Alleviate Neurologic Manifestations of COVID-19? |
Oliveira, AC, Richards, et al |
Frontiers in Neuroscience |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of COVID-19 on orthopaedic clinical service, education and research in a university hospital |
Ong, MTY, Ling, et al |
Journal of Orthopaedic Translation |
Commentary/Editorial| Commentaire/Éditorial |
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Opiłowska, E |
European Societies |
Commentary/Editorial| Commentaire/Éditorial |
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Flattening the Curve: Why the Law Should Allow for Compulsory Testing in a Pandemic |
O'Shea, Bill, Taffe, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Oude Munnink, BB, Nieuwenhuijse, et al |
Nature medicine |
Commentary/Editorial| Commentaire/Éditorial |
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The impact of COVID-19 on children from poor families in Ghana and the role of welfare institutions |
Owusu, LD, Frimpong-Manso, et al |
Journal of Children's Services |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Impacts on Bank Stability in a Liquidity-Backed Environment |
Ozsoy, SM |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Fire, pestilence and the extractive economy: cultural policy after cultural policy |
Pacella, J, Luckman, et al |
Cultural Trends |
Commentary/Editorial| Commentaire/Éditorial |
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Pagano, MT, Peruzzu, et al |
Frontiers in Endocrinology |
Commentary/Editorial| Commentaire/Éditorial |
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Palmer, S, Martin, et al |
European Human Rights Law Review |
Commentary/Editorial| Commentaire/Éditorial |
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Pan, D, Yang, et al |
PLoS One |
Commentary/Editorial| Commentaire/Éditorial |
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Global Research Status and Development of COVID-19 in 2020: A Bibliometric Analysis |
Pan, Xiaobin, Lin, et al |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
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Panknin, HT, Trautmann, et al |
Hygiene + Medizin |
Commentary/Editorial| Commentaire/Éditorial |
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Emotional Response of US Breast Cancer Survivors During the COVID-19 Pandemic |
Papautsky, EL, Hamlish, et al |
Cancer Invest |
Commentary/Editorial| Commentaire/Éditorial |
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Australian universities in a pandemic world: transforming a broken business model? |
Parker, LD |
Journal of Accounting and Organizational Change |
Commentary/Editorial| Commentaire/Éditorial |
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Tenecteplase (and common sense) in short supply during the COVID-19 pandemic |
Parsons, M, Churilov, et al |
Med J Aust |
Commentary/Editorial| Commentaire/Éditorial |
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Patel, KB, Fong, et al |
Dental update |
Commentary/Editorial| Commentaire/Éditorial |
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Towards Safety and Sustainability: Designing Local Recommendations for Post-pandemic World |
Patro, GK, Chakraborty, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Penninga, L, Arvesen, et al |
Forum for Nordic Dermato-Venerology |
Commentary/Editorial| Commentaire/Éditorial |
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Penninga, L, Arvesen, et al |
Forum for Nordic Dermato-Venerology |
Commentary/Editorial| Commentaire/Éditorial |
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Petersen, SB, Arvesen, et al |
Forum for Nordic Dermato-Venerology |
Commentary/Editorial| Commentaire/Éditorial |
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Pezzuto, Ivo |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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The Impact of Science-Unbased Measures Against COVID-19 in Clinical Decision-Making Process |
Pimentel, JVC, TDOS, et al |
AAPS PharmSciTech |
Commentary/Editorial| Commentaire/Éditorial |
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Pinnig, J |
Hygiene + Medizin |
Commentary/Editorial| Commentaire/Éditorial |
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Platton, S, Bowles, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
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Polo, SMT |
Peace Economics, Peace Science and Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Pothiawala, S |
Qatar Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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CD147 inhibitors as a treatment for melanoma: promising agents against SARS-CoV-2 infection |
Pourani, MR, Nekooghadam, et al |
Dermatol Ther |
Commentary/Editorial| Commentaire/Éditorial |
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Special Issue: Communicating Risk and Uncertainty in the Face of COVID-19 |
Priest, S, Myrick, et al |
Science Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Provenzi, L, Grumi, et al |
Acta Paediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Radhakrishnan, VS, Sukumaran Nair, et al |
ecancermedicalscience |
Commentary/Editorial| Commentaire/Éditorial |
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Alopecia and Gray Hair Are Associated with COVID-19 Severity |
Ramos, PM, Ianhez, et al |
Exp Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Novel MEC based Approaches for Smart Hospitals to Combat COVID-19 Pandemic |
Ranaweera, PS, Liyanage, et al |
IEEE Consumer Electronics Magazine |
Commentary/Editorial| Commentaire/Éditorial |
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Ranisch, R, Nijsingh, et al |
Ethics and Information Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Ransing, R, Kar, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Rasmussen, AL, Escandón, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
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Rebeiro, PF, Duda, et al |
Journal of the International AIDS Society |
Commentary/Editorial| Commentaire/Éditorial |
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Rempe, C |
Deutsche Lebensmittel-Rundschau |
Commentary/Editorial| Commentaire/Éditorial |
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The role of Interleukin-4 in COVID-19 associated male infertility – A hypothesis |
Renu, K, Subramaniam, et al |
Journal of reproductive immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Disruption of healthcare amid covid-19 pandemic in bangladesh |
Reza, HM, Sultana, et al |
Open Public Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Ridley, W, Devadoss, et al |
Applied Economic Perspectives and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Guiding documents for disaster risk reduction and management in health care system of Nepal |
Rijal, S, Adhikari, et al |
Journal of the Nepal Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Rodrigues, M, Gelabert, et al |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
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33053021; Reply to: Temporal evolution of tomographic findings of pulmonary infection
in COVID-19 |
Rosa, MEE, Matos, et al |
Einstein (Sao Paulo, Brazil) |
Commentary/Editorial| Commentaire/Éditorial |
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Persistent symptoms after acute COVID-19 infection: importance of follow-up |
Rosales-Castillo, A, García de los Ríos, et al |
Medicina clinica |
Commentary/Editorial| Commentaire/Éditorial |
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Rubin, EJ, Baden, et al |
The New England journal of medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of Senior Government Policies on the Renewal of Built Capital for Rural Non-Profits |
Ryser, L, Halseth, et al |
Community Development |
Commentary/Editorial| Commentaire/Éditorial |
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Sá, MJ, Serpa, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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A do-it–yourself video laryngoscope for endotracheal intubation of COVID-19 positive patient |
Saha, S |
Indian Journal of Anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Saha, S, Tan, et al |
Clinical orthopaedics and related research |
Commentary/Editorial| Commentaire/Éditorial |
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Fifth International Workshop on Health Recommender Systems (HealthRecSys 2020) |
Said, A, Schäfer, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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How has the relationship between oil and the US stock market changed after the Covid-19 crisis? |
Sakurai, Y, Kurosaki, et al |
Finance Research Letters |
Commentary/Editorial| Commentaire/Éditorial |
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The Psychological and Social Impact of Covid-19: New Perspectives of Well-Being |
Saladino, V, Algeri, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Chemosensory dysfunction in Coronavirus disease 2019 (COVID-19) |
Samaranayake, L, Fakhruddin, et al |
Dental update |
Commentary/Editorial| Commentaire/Éditorial |
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Samaranayake, L, Shun Li, et al |
Dental update |
Commentary/Editorial| Commentaire/Éditorial |
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Lurking Reduction at School Through Virtual Communities of Practice: The Binario 9 ¾ Project |
Sartori, F, Maga, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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32828138; Healthcare crisis in Bangladesh during the COVID-19 pandemic |
Sayeed Al-Zaman, M |
American Journal of Tropical Medicine and Hygiene |
Commentary/Editorial| Commentaire/Éditorial |
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Schimmel, P |
Enzymes |
Commentary/Editorial| Commentaire/Éditorial |
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For the Greater Good? The Devastating Ripple Effects of the Covid-19 Crisis |
Schippers, MC |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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The economic effects of covid-19 on the producers of ethanol, corn, gasoline, and oil |
Schmitz, A, Moss, et al |
Journal of Agricultural and Food Industrial Organization |
Commentary/Editorial| Commentaire/Éditorial |
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A Luta Continua1: Next Steps for Racism Research Among Black American Youth |
Seaton, EK |
Child Development Perspectives |
Commentary/Editorial| Commentaire/Éditorial |
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Segal, JP, Smith, et al |
Gastrointestinal endoscopy |
Commentary/Editorial| Commentaire/Éditorial |
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Letter to the Editor: Electroencephalography at the time of COVID-19 pandemic in Italy |
Selioutski, O, Sinha, et al |
Neurol Sci |
Commentary/Editorial| Commentaire/Éditorial |
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33034579; COVID-19 ve RAAS blokerleri: Aliskiren uygun bir seçenek olabilir mi? |
Şen, S, Üresin, et al |
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir |
Commentary/Editorial| Commentaire/Éditorial |
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Hyperbaric oxygen therapy: Can it be a novel supportive therapy in COVID-19? |
Senniappan, K, Jeyabalan, et al |
Indian Journal of Anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Seo, H, Britton, et al |
New Media and Society |
Commentary/Editorial| Commentaire/Éditorial |
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32697900; Telemedicina y humanización de la atención médica en la pandemia Covid-19 |
Sevilla-Fuente, S, Hernández-Medel, et al |
Salud publica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Compounding education disengagement: COVID-19 lockdown, the digital divide and wrap-around services |
Seymour, K, Skattebol, et al |
Journal of Children's Services |
Commentary/Editorial| Commentaire/Éditorial |
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Shapiro, MA |
Acad Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Shi, DK, Hu, et al |
Journal of Shanghai Jiaotong University (Medical Science) |
Commentary/Editorial| Commentaire/Éditorial |
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Shirzad, F, Hadi, et al |
Prim Care Companion CNS Disord |
Commentary/Editorial| Commentaire/Éditorial |
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Shrivastva, N, Devi, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Shruti, VC, Pérez-Guevara, et al |
Marine pollution bulletin |
Commentary/Editorial| Commentaire/Éditorial |
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Health digital technology in COVID-19 pandemic: Experience from China |
Shu, M, Li, et al |
BMJ Innovations |
Commentary/Editorial| Commentaire/Éditorial |
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33040728; Fungal infections in covid-19-positive patients: A lack of optimal treatment
options |
Silva, LN, de Mello, et al |
Current Topics in Medicinal Chemistry |
Commentary/Editorial| Commentaire/Éditorial |
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Urban wildlife in times of COVID-19: What can we infer from novel carnivore records in urban
areas? |
Silva-Rodríguez, EA, Gálvez, et al |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
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Facemasks as a COVID-19 barrier: a window into the overlooked experience of chronic dyspnoea? |
Similowski, Thomas, Moricot, et al |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Şimşek Yavuz, S |
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir |
Commentary/Editorial| Commentaire/Éditorial |
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Singh, AK, Rathod, et al |
Skinmed |
Commentary/Editorial| Commentaire/Éditorial |
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32875611; SARS-CoV-2 and Trojan horse phenomenon–caveat in vaccine quest? |
Singh, M, Pawar, et al |
Scandinavian Journal of Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Head and neck cancer in times of COVID-19: Emotion-based medicine |
Sistiaga Suárez, JA, López Álvarez, et al |
Acta Otorrinolaringologica Espanola |
Commentary/Editorial| Commentaire/Éditorial |
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Religious Leaders in Politics: Rio de Janeiro Under the Mayor-Bishop in the Times of the Pandemic |
Siuda-Ambroziak, R, Bahia, et al |
International Journal of Latin American Religions |
Commentary/Editorial| Commentaire/Éditorial |
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What Coronavirus Disease 2019 Has Taught Us about Modern Electrophysiology Practice |
Sohinki, D, Berman, et al |
Journal of Innovations in Cardiac Rhythm Management |
Commentary/Editorial| Commentaire/Éditorial |
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Severity of dizziness increased in dizzy patients during Covid-19 process |
Soylemez, E, Ertugrul, et al |
Hearing, Balance and Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Spicer, A |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Srinivasan, S, Sundaram, et al |
Gastroenterology and Hepatology |
Commentary/Editorial| Commentaire/Éditorial |
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Stallmach, A, Sturm, et al |
Zeitschrift fur Gastroenterologie |
Commentary/Editorial| Commentaire/Éditorial |
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Steffens, F |
Biometric Technology Today |
Commentary/Editorial| Commentaire/Éditorial |
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Stricker, RB, Fesler, et al |
Infection and Drug Resistance |
Commentary/Editorial| Commentaire/Éditorial |
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Suyadi, Nuryana, Z, et al |
International Journal of Disaster Risk Reduction |
Commentary/Editorial| Commentaire/Éditorial |
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Suzumura, EA, Zazula, et al |
Revista Brasileira de terapia intensiva |
Commentary/Editorial| Commentaire/Éditorial |
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Sviridov, D, Miller, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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A Service Response to the Pandemic: Open Circle and Restorative Justice During COVID-19 |
Swida, A |
Australian Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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Swogger, SE |
Journal of Electronic Resources in Medical Libraries |
Commentary/Editorial| Commentaire/Éditorial |
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Mining Hidden Topics from Newspaper Quotations: The COVID-19 Pandemic |
Ta, TH, Rahman, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Tabah, A, Ramanan, et al |
Journal of critical care |
Commentary/Editorial| Commentaire/Éditorial |
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Taleb, NN, Bar-Yam, et al |
International Journal of Forecasting |
Commentary/Editorial| Commentaire/Éditorial |
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Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19 |
Talukdar, J, Bhadra, et al |
Biomedicine and Pharmacotherapy |
Commentary/Editorial| Commentaire/Éditorial |
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Organizational agility assessment of a moroccan healthcare organization in times of COVID-19 |
Tamtam, F, Tourabi, et al |
Advances in Science, Technology and Engineering Systems |
Commentary/Editorial| Commentaire/Éditorial |
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Adapting to post-COVID19 research in Parkinson's disease: Lessons from a multinational
experience |
Tan, EK, Albanese, et al |
Parkinsonism and Related Disorders |
Commentary/Editorial| Commentaire/Éditorial |
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Tanboon, J, Nishino, et al |
Muscle Nerve |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 pandemic – Impact on elderly and is there a gender bias? |
Tandon, VR, Meeta, et al |
Journal of Mid-Life Health |
Commentary/Editorial| Commentaire/Éditorial |
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Tanzer, M, Racaniello, et al |
Canadian journal of surgery.Journal canadien de chirurgie |
Commentary/Editorial| Commentaire/Éditorial |
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Public Engagement With Science Among Religious Minorities: Lessons From COVID-19 |
Taragin-Zeller, L, Rozenblum, et al |
Science Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Teixeira da Silva, JA |
Online Information Review |
Commentary/Editorial| Commentaire/Éditorial |
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Téral, S, Bosco, et al |
Optics and Photonics News |
Commentary/Editorial| Commentaire/Éditorial |
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Thakkar, S |
Dental update |
Commentary/Editorial| Commentaire/Éditorial |
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The Khoa, D, Wang, et al |
Service Industries Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Tian, M, Sun, et al |
Journal of Chinese Institute of Food Science and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Tienken, CH |
Kappa Delta Pi Record |
Commentary/Editorial| Commentaire/Éditorial |
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33050993; Thalidomide Should Be Tested as a Therapeutic Option in COVID-19 Pneumonia |
Tiscornia, JE, Poggio, et al |
Skinmed |
Commentary/Editorial| Commentaire/Éditorial |
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Early impact of covid-19 outbreak on the availability of cornea donors: Warnings and recommendations |
Toro, M, Choragiewicz, et al |
Clinical Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
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Travis, CR |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Trede, F, Flowers, et al |
International Journal of Work-Integrated Learning |
Commentary/Editorial| Commentaire/Éditorial |
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Tregoning, J |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Ontological implications in the learning of social distancing of covid-19 pandemic |
Trejos-Gil, C, Castro-Escobar, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Tretter, F, Tretter, et al |
GAIA |
Commentary/Editorial| Commentaire/Éditorial |
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Unprecedented but not Unpredictable: Effects of the COVID-19 Crisis on Commodity-Dependent Countries |
Tröster, B, Küblböck, et al |
European Journal of Development Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Truman, A, Forbes-Haley, et al |
Dental update |
Commentary/Editorial| Commentaire/Éditorial |
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Trzupek, B |
Computer Fraud and Security |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Response and Lessons Learned on Dengue Control in Bhutan |
Tsheten, T, Wangchuk, et al |
J Med Entomol |
Commentary/Editorial| Commentaire/Éditorial |
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Tele-operative Robotic Lung Ultrasound Scanning Platform for Triage of COVID-19 Patients |
Tsumura, Ryosuke, Hardin, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
|
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Tung, LT |
Asia Pacific Journal of Social Work and Development |
Commentary/Editorial| Commentaire/Éditorial |
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De Novo ANCA-Associated Vasculitis With Glomerulonephritis in COVID-19 |
Uppal, NN, Kello, et al |
Kidney International Reports |
Commentary/Editorial| Commentaire/Éditorial |
|
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Potential Challenges for Coronavirus (SARS-CoV-2) Vaccines Under Trial |
Usmani, SS, Raghava, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Cochlear Implant Surgery During the Covid Pandemic Lockdown—The KEM Hospital, Pune Experience |
Vaid, N, Vaze, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
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van der Elst, LA, Gokce Kurtoglu, et al |
Advanced Engineering Materials |
Commentary/Editorial| Commentaire/Éditorial |
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Vanin, AF |
Biophysics (Russian Federation) |
Commentary/Editorial| Commentaire/Éditorial |
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Vasudevan, RS, Bin Thani, et al |
European heart journal |
Commentary/Editorial| Commentaire/Éditorial |
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Dexamethasone and remdesivir: finding method in the COVID-19 madness |
Vetter, Pauline, Kaiser, et al |
The Lancet Microbe |
Commentary/Editorial| Commentaire/Éditorial |
|
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Vinson, V |
Science |
Commentary/Editorial| Commentaire/Éditorial |
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Vinson, V |
Science |
Commentary/Editorial| Commentaire/Éditorial |
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Vroegindewey, G |
Revue scientifique et technique (International Office of Epizootics) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wang, HC, Wang, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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When the Open Source Community Meets COVID-19: Characterizing COVID-19 themed GitHub Repositories |
Wang, Liu, Li, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Wannous, C |
Revue scientifique et technique (International Office of Epizootics) |
Commentary/Editorial| Commentaire/Éditorial |
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Infographic. Stay physically active during COVID-19 with exercise as medicine |
Wedig, IJ, Duelge, et al |
Br J Sports Med |
Commentary/Editorial| Commentaire/Éditorial |
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Weine, S, Bunn, et al |
Intervention |
Commentary/Editorial| Commentaire/Éditorial |
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Welz, A, Breś-Targowska, et al |
Acta Poloniae Pharmaceutica - Drug Research |
Commentary/Editorial| Commentaire/Éditorial |
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West, EA, Anker, et al |
Int J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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White, C |
Contemporary Psychoanalysis |
Commentary/Editorial| Commentaire/Éditorial |
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Rapid Rise of COVID-19 second wave in Myanmar and Implications for the Western Pacific Region |
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Qjm |
Commentary/Editorial| Commentaire/Éditorial |
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Dilemma in Handling Corpse with COVID-19 Protocol at Hospital in Padang, West Sumatera
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Windasari, Noverika, Manela, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Heart transplantation to fulminant myocarditis during COVID-19 outbreak |
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Commentary/Editorial| Commentaire/Éditorial |
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Wiwanitkit, V |
Journal of Laparoendoscopic and Advanced Surgical Techniques |
Commentary/Editorial| Commentaire/Éditorial |
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Maintaining medical team communication using video conferencing during the COVID-19 lockdown |
Wotherspoon, RJ, Mannion, et al |
British Journal of Oral and Maxillofacial Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Wu, HC, Wang, et al |
Mathematics |
Commentary/Editorial| Commentaire/Éditorial |
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Wu, T |
Front Med |
Commentary/Editorial| Commentaire/Éditorial |
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Yang, F, Yuan, et al |
Ann Emerg Med |
Commentary/Editorial| Commentaire/Éditorial |
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Yeh, YYA |
Acad Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Zabaniotou, A, Syrgiannis, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Responding to an international crisis: The adaptability of the practice of work-integrated
learning |
Zegwaard, KE, Judene Pretti, et al |
International Journal of Work-Integrated Learning |
Commentary/Editorial| Commentaire/Éditorial |
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Ziritt Trejo, G, Moreno Freites, et al |
Utopia y Praxis Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Psychol Health Med |
Commentary/Editorial| Commentaire/Éditorial |
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British dental journal |
Commentary/Editorial| Commentaire/Éditorial |
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33043635; Risk Variant for Severe COVID-19 Inherited from Neanderthals |
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American journal of medical genetics.Part A |
Commentary/Editorial| Commentaire/Éditorial |
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33037379; Measures undertaken by the dental profession have aided post-COVID-19 recovery |
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British dental journal |
Commentary/Editorial| Commentaire/Éditorial |
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Welcome to the Ninth World Congress of Veterinary Dermatology! |
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Veterinary dermatology |
Commentary/Editorial| Commentaire/Éditorial |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives