Good afternoon,
There are 670 citations in today’s scan. 361 were considered primary research or review literature.
Highlights today include:
CANADA
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Dewar et al. sought to explore Canadian physicians' preparedness and attitudes regarding resource
allocation decisions. This rapidly implemented survey suggests that a sample of Canadian physicians feel underprepared to make resource allocation decisions, and desire both more emotional support and clear, transparent, evidence-based policy.
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Edjoc et al. a mathematical tool and time-dependent reproduction number (Rt) estimates to assess the COVID-19 pandemic progression in a Canadian context.
For Canada as a whole, the testing graphs had a slightly concave profile and a coincident decrease in Rt estimates. Saskatchewan more recently had a convex profile with a gradual shift to a concave profile and also demonstrated a gradual decline in Rt estimates.
Curves and Rt estimates for Alberta, British Columbia, Manitoba, Nova Scotia, Ontario and Quebec displayed a gradual shift towards concavity over time and an overall decrease in Rt estimates, which is suggestive of a positive impact of public health interventions
implemented federally and provincially.
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Pierce et al conducted an ecological study using data from Canada’s national influenza surveillance system to investigate whether
social distancing measures to control COVID-19 reduced the incidence of seasonal influenza. Our results indicate a premature end to the 2019-20 influenza season, with a significantly fewer number of cases and outbreaks being recorded following the enactment
of many COVID-19 social distancing polices. The incidence of influenza strains A (H3N2), A (unsubtyped), and B were all significantly lower at the tail-end of the 2019-20 influenza season, compared with preceding seasons.
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Siu, et al.
conducted an online cross-sectional survey of Ontario LTC Clinicians working in LTC homes to provide the clinician perspective on the preparedness and engagement of the LTC sector during the COVID-19 pandemic. The overall response rate was 54% (160/294).
LTC homes implemented a wide range of important interventions. This study highlights the communication and implementation of recommendations in the Ontario LTC sector, despite some concerns regarding feasibility.
PUBLIC HEALTH INTERVENTION
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Cai et al.
evaluate the safety of reopening universities and colleges using a combined strategy in China. The returning to school was guided by a combined strategy including use of personal protective equipment, management of transportation,
serological and nucleic acid tests for COVID-19, quarantine, and restrictions in and out of campus. Among 13,116 participants, 4067 tested for SARS-CoV-2 nucleic acid and no positive
results were identified. Using a combined strategy for COVID-19 prevention and control, safely reopening of universities and colleges in low-risk regions is possible and laboratory screening for SARS-CoV-2 infection
may not be necessary.
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Klimek-Tulwin & Tulwin
assess the effect of school closures on the COVID-19 pandemic and epidemic trajectories. Their data indicate that there was a strong correlation between the day of educational facilities closure and the incidence rate in the following days. Early closure
of schools in analyzed countries is statistically significantly correlated with lower incidence rates further on during the different phases of the epidemic.
TRANSMISSION
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Brito et al.
report an outbreak in 24 members of a family cluster during a period of social distancing. All patients had mild symptoms, requiring no hospitalization, and none of them died. The frequency of symptomatic, laboratory-confirmed
patients was higher among adults (94%) than among children (50%); the paediatric age group also had a higher frequency of exposed individuals who remained negative for infection.
EPIDEMIOLOGY
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Kociolek et al
look at the distribution of upper respiratory viral loads (VL) in asymptomatic children infected with SARS-CoV-2 vs symptomatic children infected with SARSS-CoV-2. They find that Children with asymptomatic SARS-CoV-2 infection had lower levels of virus
in the nasopharynx/oropharynx than symptomatic children, but timing of infection relative to diagnosis likely impacted levels in asymptomatic children.
SEROLOGY
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Harris et al.
undertook prospective serosurveillance in a cohort of healthy adults in England. Two thousand two hundred forty-seven individuals were recruited, and 2014 (90%) had 3-5 monthly antibody tests. Over the study period, SARS-CoV-2 seropositivity was 8-10%
overall and up to 21% in clinical healthcare workers. In seropositive individuals, nucleoprotein and spike protein IgG antibodies declined with time after infection, and 50% are predicted to fall below the positive test threshold after six months.
CLINICAL DATA
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Kaya et al
evaluate the presence of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) virus in tears and conjunctival secretion of patients with COVID-19. A prospective interventional case series study was performed, and 32 patients with COVID-19 were
selected at the Pamukkale University Hospital from 15 to 22 May 2020. Five of 32 patients (16 %) without conjunctivitis or any eye symptoms had viral RNA in their tear-conjunctival samples.
VACCINE RESEARCH
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Kurup et al
show the rapid development of a novel, highly efficient, and safe COVID-19 vaccine using a rabies virus-based vector that has proven to be an efficient vaccine against several emerging infectious diseases. Their study reports that both a live and an
inactivated rabies virus containing the SARS-CoV-2 spike S1 protein induces potent virus-neutralizing antibodies at much higher levels than seen in the sera of convalescent patients.
THERAPEUTICS
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Unni et al.
find the molecule, Bisoxatin may be a promising repurposable drug molecule to develop new chemical libraries for inhibiting SARS-CoV-2 entry into host cells. Bisoxatin (DB09219), which is used for the treatment of constipation and preparation of the
colon for surgical procedures.
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Rocco et al. performed a multicenter, randomized, double-blind, placebo-controlled trial to investigate the therapeutic effect of the antiparasitic drug
nitazoxanide on SARS-CoV-2 infection. In patients with mild Covid-19, symptom resolution did not differ between the nitazoxanide and placebo groups after 5 days of therapy. However, early nitazoxanide therapy was safe and reduced viral load significantly.
DIAGNOSTICS
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Fellous et al
test serum samples of RT-PCR SARS-CoV-2 positive patients (n=2594) for IgM/IgG/IgA against the virus using 31 commercial assays. Contrasted performances were observed among the evaluated commercial assays. Rapid tests for qualitative detection of anti-SARS-CoV-2
antibodies (RDTs) achieved 77.4-100%, and ELISA/CLIA (ELISA) assays 58.8-100% for SARS-CoV-2-specific total antibodies (TAb) specificity. From 15 days after onset of symptoms, 13/18 RDT and 8/13 ELISA reached sensitivity > 90%. Contrasted performances were
observed among the 31 commercial assays we evaluated.
PUBLIC HEALTH RESPONSE
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Paul et al
estimate predictors of negative attitudes towards vaccines and identify groups most at risk of uncertainty and unwillingness to receive a COVID-19 vaccine in a large sample of UK adults. 16% of respondents displayed high levels of mistrust or misinformation
about vaccines across one or more domains. Overall, 14% of respondents reported unwillingness to receive a vaccine for COVID-19, whilst 22% were unsure. The largest predictors of both COVID-19 vaccine uncertainty and refusal were low income, having not received
a flu vaccine last year, poor adherence to COVID-19 government guidelines, female gender, and living with children. Amongst vaccine attitudes, intermediate to high levels of vaccine benefit mistrust and concerns about future unforeseen side effects were the
most important determinants of both uncertainty and unwillingness to vaccinate against COVID-19.
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Schulman, et al.
conducted an electronic survey in October, 2020 among individuals primarily age 60 and older regarding their degree of confidence of deriving personal protection from 8 different anti‐COVID interventions – social isolation, lockdowns, avoiding restaurants,
taking MMR vaccine, wearing masks when indoors with others, avoiding hotels, avoiding commercial air travel, and using the first future specific anti‐COVID vaccine. Responses were received from 135 persons from many different U.S. regions and 5 foreign countries.
None were strongly supported by a majority of respondents, but those receiving the largest proportions of strong support were social isolation (41%), wearing masks indoors (41%), and using the first anti‐COVID vaccine (41%).
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura
Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Alex Gilbert, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak, David Knox
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
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AbdulRahman, A, AlAli, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study was undertaken to see if COVID-19 infection increased disease severity in patients with sickle cell disease (SCD) mutation. A total of 38,092
Bahraini people were tested for COVID-19 during this period; 378 (1%) were SCD patients. Six patients with SCD had COVID-19 (1.6%): three remained asymptomatic, two had mild symptoms and one required oxygen therapy. The SCD patients had a similar average length
of stay when compared with non-SCD COVID-19 patients (10.7 days). |
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Abrahão, JS, Sacchetto, et al |
Science of the Total Environment |
Epidemiology| Épidémiologie |
This study investigated the presence of SARS-CoV-2 RNA on public surfaces in a densely populated urban area in Brazil. Forty-nine of 933 samples tested
positive (5.25%) for SARS-CoV-2 RNA, including samples collected from distinct material surfaces, including metal and concrete, and distinct places, mainly around hospital care units and public squares. The data indicated the contamination of public surfaces
by SARS-CoV-2, suggesting the circulation of infected patients and the risk of infection for the population. |
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Adamik, Barbara, Bawiec, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Transmission |
This study analysed 16115 Polish surveillance records to obtain key figures of the COVID-19 pandemic. By maximum likelihood estimates, the total number
of COVID-19 cases in Poland as of July 22nd, 2020, is at most around 13 times larger and at least 1.6 times larger than the recorded number. The lower bound on the severeness rate ranges between 0.2% for the 0--39 year-old to 5.7 % for older than 80, while
the upper bound is between 2.6% and 34.1%. The lower bound on the death rate is between 0.04% for the age group 40--59 to 1.34% for the oldest. Overall, the severeness and death rates grows exponentially with age. The in-household attack ratio is 8.18% for
the youngest group and 16.88% for the oldest. |
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Decrease in Hospitalizations for COVID-19 after Mask Mandates in
1083 U.S. Counties |
Adjodah, Dhaval, Dinakar, et al |
medRxiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study determined if facial mask mandates instituted in U.S. counties over the spring and summer of 2020 were associated with declining severity of
infection as measured by the number of hospitalizations for COVID-19. Using data from 1083 counties (34% of U.S. counties, 82% of U.S. population) from 49 states, we found a statistically significant drop in hospitalization rates due to COVID-19 up to 12 weeks
following county mask mandates of 7.13 (95%CI: -4.19, -10.1) percentage points, after controlling for age categories by county, testing access, numbers of cases, and population mobility. Facial masking may decrease COVID-19 severity by decreasing the viral
inoculum to which individuals are exposed. |
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33020114; Association of smoking status with outcomes in hospitalised patients with COVID-19 |
Adrish, M, Chilimuri, et al |
BMJ Open Respiratory Research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This single-centre retrospective study examined if smoking was associated with development of critical illness and
higher likelihood of death. 1173 patients met the study criteria. Patients in smokers group were more likely to be male and had higher incidence of underlying chronic obstructive pulmonary disease (19% vs 6%, p<0.001), HIV infection (11% vs 5%,p<0.001), cancer
(11% vs 6%, p=0.005), congestive heart failure (15% vs 8%, p<0.001), coronary artery disease (15% vs 9%, p=0.3), chronic kidney disease (11% vs 8%, p=0.037) and end-stage renal disease (10% vs 6%, p=0.009) compared with non-smokers. Outcome analysis showed
that smokers were more likely to develop critical illness requiring mechanical ventilation (47% vs 37% p=0.005). Univariate Cox model for survival analysis by smoking status showed that among smokers only current smokers had higher risk of death compared with
never smokers (HR 1.61, 95% CI 1.22 to 2.12, p<0.001). |
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A Visual Analytics Based Decision Making Environment for COVID-19 Modeling and Visualization |
Afzal, Shehzad, Ghani, et al |
arXiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique Healthcare Response | Réponse des soins de santé |
This study developed a visual analytics environment that enables public health officials to model, simulate, and explore
the spread of COVID-19 by supplying county-level information such as population, demographics, and hospital beds. This environment facilitates users to explore spatiotemporal model simulation data relevant to COVID-19 through a geospatial map with linked statistical
views, apply different decision measures at different points in time, and understand their potential impact. Users can drill-down to county-level details such as the number of sicknesses, deaths, needs for hospitalization, and variations in these statistics
over time. |
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Agarwal, A, Mukherjee, et al |
Bmj |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
This study investigated the effectiveness of using convalescent plasma to treat moderate coronavirus disease 2019
(covid-19) in adults in India. Progression to severe disease or all cause mortality at 28 days after enrolment occurred in 44 (19%) participants in the intervention arm and 41 (18%) in the control arm (risk difference 0.008 (95% confidence interval -0.062
to 0.078); risk ratio 1.04, 95% confidence interval 0.71 to 1.54). Convalescent plasma was not associated with a reduction in progression to severe covid-19 or all cause mortality |
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Agarwal, S, Conway, et al |
AJNR Am J Neuroradiol |
Clinical data| Données cliniques |
This study described the clinical and imaging features of acute disseminated leukoencephalopathy in critically ill
patients with COVID-19 and the imaging evolution during a short-term follow-up. All patients demonstrated multiple areas of white matter changes in both cerebral hemispheres; 87.5% (7/8) of patients had a posterior predilection. Four patients (50%) had short-term
follow-up imaging within a median of 17 days after the first MR imaging; they developed brain atrophy, and their white matter lesions evolved into necrotizing cystic cavitations. All (8/8) patients had inflammatory cytokine release syndrome as demonstrated
by elevated interleukin-6, D-dimer, lactate dehydrogenase, erythrocyte sedimentation rate, C-reactive protein, and ferritin levels. Most (7/8; 87.5%) patients were on prolonged ventilator support (median, 44.5 days; interquartile range, 20.5 days). These patients
had poor functional outcomes (6/8 75%] patients were discharged with mRS 5) and high mortality (2/8, 25%). |
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Machine learning models for the prediction the necessity
of resorting to icu of covid-19 patients |
Agieb, RS |
International Journal of Advanced Trends in Computer Science and Engineering |
Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins
de santé |
This research tries to find models to predict the patient's need to enter ICU or not. The prediction models depend
on Machine Learning (ML). Three models will be built to predict the state at which the patient needs to enter the ICU or not. The proposed predictor models based on three types of Supervised machine learning Naive Bayes, K-nearest neighbor (K-NN), and Support
Vector Machine (SVM) according to the scarce datasets. Predictor model trained based on Extracted features from patients’ X-ray images. |
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The COVID-19 pandemic and the antecedants for the impulse buying behavior of US citizens |
Ahmed, RR, Streimikiene, et al |
Journal of Competitiveness |
Public Health response| Interventions de santé publique |
In an analysis based on the theory of Fear, this study examines impulse purchase patterns during the COVID-19 Pandemic
across major US urban centers. The results confirmed that Fear of a complete lockdown, peers buying, scarcity of essential products on shelves, US stimulus checks, the limited supply of essential goods, and panic buying have had a compelling and affirmative
influence on the sharp swings of impulse buying patterns. The findings further confirm that Fear Appeal and social media fake news have had a strong positive impact on impulse buying as mediating factors. Finally, it was concluded that COVID-19 is a significant
moderating factor influencing the impulse buying behavior of US citizens. |
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Genetic variations among SARS-CoV-2 strains isolated in China |
Ahmed-Abakur, E, Alnour, et al |
Gene Reports |
Coronavirology| Coronavirologie |
This study aimed to determine genetic variations among SARS-CoV-2 strains isolated in China. Sixty six complete genome
sequences of the virus were retrieved from NCBI, the sequence of original Wuhan strain accession number NC 045512 was used as the reference sequence. The collected sequences showed 10 different variants. One hundred and thirty four mutations were identified
among the variants of SARS-CoV-2; most of them 52.2% (70/134) were missense point mutation, majority of the mutations 65.7% (88/134) occurred in the open reading frame a/b (ORFab), few mutations occurred in the structural viral genome, each of spike (S) gene
and nucleocapsid (N) gene showed 4 mutations; 2 silent point mutations and 2 missense point mutations occurred in each gene whereas membrane (M) gene showed silent point mutation and no mutation observed in the envelope E gene. The remarkable observation showed
by Yunnan variant accession number MT226610 which exhibited high incidence of mutations, it displayed 28 different point mutations; only 3(10.7%) of them were silent mutations while the rest were missense mutations. |
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Alabbadi, H, Al-Masaeed, et al |
Journal of Theoretical and Applied Information Technology |
Public Health response| Interventions de santé publique |
This research identifies the impact of the ICT dimensions (readiness of ICT infrastructure, human resource skills and
knowledge, and financial capabilities) in managing the coronavirus crisis. The research results show a presence of a statistically significant effect of ICT in the management of the coronavirus crisis in addition to other interesting results about areas that
need improvements and attention in crises management centers. |
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Ali, M, Ahsan, et al |
BMC Res Notes |
Public Health response| Interventions de santé publique |
This study evaluated the immediate impacts of COVID-19 stay-at-home orders on the mental well-being of Bangladeshi
adults. The overall mean score for well-being was 42.4, indicating that 51.9% of adults suffered from poor mental health. And within that 48% of males and 57% of females were depressed. The mean scores for government workers, unemployed workers, and business
employees were 45.1, 39.6, and 39.5, respectively. Confounding adjustments in multivariable linear regression models revealed that married women, unemployed and business communities, and individuals returning to villages were heavily depressed. Stay-at-home
orders had significant repercussions on mental health and created a gender disparity in depression among adults. |
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Fear from COVID-19 and technology adoption: the impact of Google Meet during Coronavirus pandemic |
Al-Maroof, R, Salloum, et al |
Interactive Learning Environments |
Public Health response| Interventions de santé publique |
This study explored the effect of fear emotion on students' and teachers' technology adoption during COVID-19 pandemic.
The study has made use of Google Meet© as an educational social platform in private higher education institutes. During the Coronavirus pandemic, fear due to family lockdown situation, fear of education failure and fear of losing social relationships are the
most common types of threat that may face students and teachers/educators. These types of fears are connected with two important factors within TAM theory, which are: perceived ease of use (PEOU) and perceived usefulness (PU), and with another external factor
of TAM, which is subjective norm (SN). The results revealed that both data analysis techniques have successfully provided support to all the hypothesized relationships of the research model. |
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Behavioral practices of patients with multiple sclerosis during Covid-19 pandemic |
Alnajashi, H, Jabbad, et al |
PLoS One |
Public Health response| Interventions de santé publique |
This study examined the behavioral practices related to Covid-19 among patients with multiple sclerosis (MS). A total
of 176 MS patients diagnosed at least one year before the survey were conveniently sampled online in Saudi Arabia. Overall, more than 80% of participants had good knowledge and attitudes towards Covid-19. However, this did not correlate well with the impact
on healthcare (r = 0.06). The study revealed that 46% of participants were anxious about taking their medication, and 32% of participants missed their hospital appointments. Furthermore, 15% of the participants had a relapse but did not go to the hospital
because of the pandemic, 15.9% stopped their DMTs, and 35.2% missed drug infusions or refills. |
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Al-Sejari, M, Al-Ma'Seb, et al |
Soc Work Public Health |
Public Health response| Interventions de santé publique |
This study examined the associations between precautionary health behaviors (eating vitamins, washing hands continuously,
eating healthy food, putting on masks, wearing gloves, and maintaining a safe distance) and illness attitudes (worry about illness, concern about pain, hypochondriacal beliefs, thanatophobia, and treatment experience). The findings show that there are significant
associations between the illness attitudes of participants and the precautionary health behaviors they adopted during the COVID-19 pandemic in Kuwait. Illness attitudes toward COVID-19 significantly affect the health behaviors of individuals. The health behaviors
become precautionary measures aimed at preventing infection from COVID-19. |
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Associations between Affect, Physical Activity, and Anxiety Among
US Children During COVID-19 |
Alves, JasminM, Yunker, et al |
medRxiv |
Public Health response| Interventions de santé publique |
This study investigated how emotional responses (positive and negative affect), physical activity (PA), and sedentary
behaviors related to anxiety among US children during the COVID 19 pandemic. Sixty four typically developing children (63% girls) age 9 to 15 years old completed two virtual visits during height of stay at home measures between April 22 to July 29, 2020.
Children completed 24 hour PA recalls, state portion of State-Trait Anxiety Inventory for Children (STAIC), and the shortened 10 item Positive and Negative Affect Schedule for Children (PANAS C). Children reported state anxiety scores that were more than 5
standard deviations greater than values from healthy pediatric populations prior to the pandemic. Children with higher positive affect and who reported more time in PA reported less state anxiety. Sedentary and leisure screen time were positively correlated
with negative affect. |
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Second layer data governance for permissioned blockchains: the privacy management challenge |
Alves, Paulo Henrique, Frajhof, et al |
arXiv |
Healthcare Response | Réponse des soins de santé |
This regulation model aims to protect users' data from misusage and leakage and allow users to request an explanation
from companies when needed. In pandemic situations, such as the COVID-19 and Ebola outbreak, the action related to sharing health data between different organizations is crucial. However, the data subject, i.e., the users, should have the right to request
the purpose of data use, anonymization, and data deletion. In this sense, permissioned blockchain technology emerges to empower users to get their rights providing data ownership, transparency, and security through an immutable, unified, and distributed database
ruled by smart contracts. The governance model discussed in blockchain applications is usually regarding the first layer governance, i.e., public and permissioned models. However, this does not cover compliance with the data regulations. In order to organize
the relationship between data owners and the stakeholders, i.e., companies and governmental entities, this study developed a second layer data governance model for permissioned blockchains based on the Governance Analytical Framework principles applied in
pandemic situations preserving the users' privacy and their duties. |
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Anyayo, Lucas Goodgame, Kabunga, et al |
medRxiv |
Public Health response| Interventions de santé publique |
This study estimated the prevalence of and associated demographic factors during COVID-19 pandemic. Results revealed
that the majority of respondents were female (53%) and 47% had a depressive disorder. There was no statistical relationship between demographics (gender, age and marital status) and depressive disorders. Findings indicate that depressive disorders are prevalent
among refugees in Nakivale settlement and it is important to identify refugees affected mentally and given proper treatment. |
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COVID-19 in 3 patients treated with immune checkpoint inhibitors for advanced melanoma |
Arenbergerova, M, Gkalpakiotis, et al |
J Dermatolog Treat |
Clinical data| Données cliniques |
Abstract and full text not available. |
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Ashiru-Oredope, D, Chan, et al |
J Pharm Policy Pract |
Healthcare Response | Réponse des soins de santé |
This study aimed to identify and explore the issues currently facing pharmacy teams across Commonwealth countries during
the COVID-19 pandemic. The study also evaluates pharmacy professionals' understanding of key knowledge areas from the COVID-19 webinar hosted by the Commonwealth Pharmacists' Association (CPA). Our study confirms pharmacy professionals' concerns about practice
during a pandemic and provides preliminary data on the challenges and learning needs of the profession. The CPA has since acted on these findings, providing ongoing opportunities to develop and refine resources for the profession as the pandemic evolves. Pharmacy
professionals have also demonstrated improved knowledge on the management of COVID-19 and resources available for professionals. |
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Aslam, A, Singh, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The study was conducted at a tertiary care cancer center in NYC. From March 22 until August 22, 2020, 11,540 unique
patients underwent 14,233 tests before surgeries or procedures at MSKCC. Overall, 65 patients were positive, with a peak rate of 4.3% that fell below 0.3 % after April 2020. For the 65 positive cases, three were pre-symptomatic, and 38 were asymptomatic. Among
asymptomatic test-positive patients, 76 % had PCR cycle threshold (Ct) > 30 at first detection. Five patients tested newly positive in the immediate post-operative period, exposing 82 employees with one case of probable transmission (1.2%). |
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Azwar, MK, Setiati, et al |
Acta medica Indonesiana |
Clinical data| Données cliniques |
Article in Indonesian. This descriptive study used complete data on elderly patients with COVID-19 who were hospitalized
at the Cipto Mangunkusumo National Central General Hospital (RSUPN Cipto Mangunkusumo) from April to the end of August 2020. In the elderly patient population (n = 44), the majority were aged between 60-69 years (68%), were male (66%), and had no prior history
of close contact with COVID-19 patients ( 86%). The most common symptoms are fever, cough, and shortness of breath which are typical symptoms of COVID-19, while the most common chronic diseases are diabetes mellitus, hypertension, and malignancy. Multimorbidity
was found in only 14% of elderly patients, and these patients survived infection with the SARS-CoV-2 virus. The mortality rate for elderly patients hospitalized with COVID-19 in this study was 23%, and 90% of the deaths were male. |
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Early Changes in Kidney Transplant Immunosuppression Regimens During the COVID-19 Pandemic |
Bae, S, McAdams-DeMarco, et al |
Transplantation |
Healthcare Response | Réponse des soins de santé |
We conducted a nationwide study to characterize immunosuppression use and subsequent clinical outcomes during the first
5 months of COVID-19 pandemic in the United States. METHODS: Using data from the Scientific Registry of Transplant Recipients, we studied all kidney-only recipients in the United States from 1/1/2017 to 3/12/2020 ("prepandemic" era; n=64 849) and from 3/13/2020
to 7/31/2020 ("pandemic" era; n=5035). RESULTS: Recipients in the pandemic era were substantially less likely to receive lymphocyte-depleting induction agents compared to their prepandemic counterparts; similar trends were found across subgroups of state-level
COVID-19 incidence, donor type, and recipient age. |
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Baildya, N, Khan, et al |
Journal of Molecular Structure |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The present work examines the inhibitory activity of Neem extracts on Papain like protease (PLpro) of the novel coronavirus
SARS-CoV-2. The activity is analysed by molecular docking study along with molecular dynamics simulation. All the studied Neem compounds showed decent level of inhibitory activity against PLpro of SARS-CoV-2. Among them, desacetylgedunin (DCG) found in Neem
seed showed the highest binding affinity towards PLpro. Furthermore, MD-simulation studies supported by standard analysis (e.g. root mean square deviation and fluctuation (RMSD, RMSF), radius of gyration, solvent accessible surface area (SASA)) showed large
impact on the structure of PLpro by DCG. We believe that the significant effect of DCG on PLpro may help in therapeutic efforts against SARS-CoV-2. |
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Balaphas, A, Gkoufa, et al |
Journal of hepatology |
Clinical data| Données cliniques |
Herein, we report the cases of 2 patients who developed COVID-19 presenting as an acute acalculous cholecystitis. |
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Baldi, E, Sechi, et al |
PLoS One |
Healthcare Response | Réponse des soins de santé |
We performed an analysis of the Lombardia Cardiac Arrest Registry comparing all the OHCAs occurred in the Provinces
of Lodi, Cremona, Pavia and Mantua (northern Italy) in the first 100 days of the epidemic with those occurred in the same period in 2019. Compared to 2019, during the 2020 COVID-19 outbreak we observed a lower attitude of laypeople to start CPR, while resuscitation
attempts by BLS and ALS staff were not influenced by suspected/confirmed infection, even at univariable analysis. |
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Bandara, S, Kennedy-Hendricks, et al |
Journal of addiction medicine |
Public Health response| Interventions de santé publique |
OBJECTIVES: To describe how the novel coronavirus (COVID-19) pandemic has affected opioid agonist treatment (OAT) programs
in jails and prisons. METHODS: In May 2020, we conducted an online survey of 19 carceral systems that provided methadone and/or buprenorphine treatment for incarcerated populations before COVID-19. Eleven survey items examined challenges and changes to these
programs as a result of the pandemic. Sixteen of 19 programs (84%) responded to the survey. RESULTS: Ten out of 16 systems reported downsizing their OAT programs. Seven of 16 systems made changes to medication dispensation processes. Half of systems report
challenges implementing physical distancing (n = 8), and/or obtaining personal protective equipment (n = 8). In 13 out of 16 systems some OAT program participants were released early due to COVID-19 infection risk. |
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Bankole, TO, Omoyeni, et al |
Journal of Public Health (Germany) |
Epidemiology| Épidémiologie |
This study examines the growth trends in the COVID-19 pandemic and fatalities arising from its complications among
tested patients in West Africa. Results showed that the trends in growth patterns of COVID-19 for Senegal, Nigeria, Ghana, Republic of Niger, and West Africa generally followed the same fluctuating curves. The COVID-19 pandemic accounted for 92.3%, 97.8%,
90.3%, 65%, 90.4%, 93.6%, and 97% of complications that led to deaths of patients in Burkina Faso, Nigeria, Senegal, Ghana, Niger Republic, Ivory Coast, and West Africa, respectively. Also, the results established that there was a significant positive association
between increased incidence of COVID-19 and percentage increase in fatalities arising from its complications in West Africa (ß = 0.032; t = 12.70; p < 0.001). |
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Bansal, A, Jain, et al |
International Journal of Academic Medicine |
Healthcare Response | Réponse des soins de santé |
This study aims to assess the psychosocial impact of COVID-19 pandemic on health-care workers (HCW) using Screening
Questionnaire for Disaster Mental Health (SQD). 5.67% HCW were suffering from severe posttraumatic stress disorder and similar 5.67% had severe depression due to COVID-19. Results analyzed by t-test found that, overall, HCWs were mildly affected by COVID-19
in terms of posttraumatic stress disorder (mean value 2.16; 95% confidence interval CI] = 1.80-2.53, P = 0.000) and depression (mean value 1.27; 95% CI = 0.97-1.57, P = 0.000) as per SQD scale. |
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Barry, IS, Baldé, et al |
Annales de Cardiologie et d'Angeiologie |
Healthcare Response | Réponse des soins de santé |
Article in French. The objective of this study was to assess the impact of the COVID-19 pandemic on the activities
of the cardiology department of the Ignace Deen National Hospital at the Conakry University Hospital. The study consisted of assessing the impact of the pandemic on patient use of the service during the first weeks of the pandemic. During this study from March
to April 2020, we identified 130 patients in consultation against 450 patients for the two months preceding the official declaration of the pandemic in Guinea, a drop of 71.1% (320 patients). The same remark was made in hospitalisation with a drop of 75% (35
patients against 140 for the two months preceding the pandemic). At the start of the COVID-19 pandemic in Guinea, it is clear that there has been a rapid and significant drop in the effective use of the cardiology service. |
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An Empirical Inference of the Severity of Resurgence of COVID-19
in Europe |
Baruah, Hemanta Kumar |
medRxiv |
Epidemiology| Épidémiologie |
In this article, we are going to analyze the current COVID-19 spread patterns in Italy, the UK, Germany, Russia, Spain
and France. We have found that the current spread has perhaps been underestimated as just the second wave. As per our analysis, as on 7 October the resurgence is much more vigorous than the first wave of spread of the disease. It is going to be most serious
in Russia, followed by Italy, Germany and the UK, while in Spain and France the patterns are yet to take inferable shapes. |
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Schnellnachweis von SARS-CoV-2 mit recombinase polymerase amplification |
Behrmann, O, Bachmann, et al |
BioSpektrum |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Article in German. The COVID-19 pandemic highlights the need for fast and simple assays for nucleic acid detection.
As an isothermal alternative to RT-qPCR, we outline the development of a detection scheme for SARS-CoV-2 RNA based on reverse transcription recombinase polymerase amplification (RT-RPA) technology. RPA uses recombination proteins in combination with a DNA
polymerase for rapid amplification of target DNA at a constant temperature (39–42 °C) within 10 to 20 minutes and can be monitored in real-time with fluorescent probes. |
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32918932; Accuracy of a RT-qPCR SARS-CoV-2 detection assay without prior RNA extraction |
Beltrán-Pavez, C, Alonso-Palomares, et al |
Journal of virological methods |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We sought to evaluate different RT-qPCR kits and protocols to evaluate the best approach to be used omitting an RNA
extraction step. We have investigated the sensitivity and performance of different commercially available RT-qPCR kits in detecting SARS-CoV-2 using 80 extracted RNA and NSS from COVID-19 diagnosed patients. We evaluated the ability of each kit to detect viral
RNA from both kit-extracted or directly from a pre-boiled NSS observing that direct RNA detection is possible when Ct values are lower than 30 with the three kits tested. Since SARS-CoV-2 testing in most locations occurs once COVID-19 symptoms are evident
and, therefore, viral loads are expected to be high, our protocol will be useful in supporting SARS-CoV-2 diagnosis, especially in America where COVID-19 cases have exploded in the recent weeks as well as in low- and middle-income countries, which would not
have massive access to kit-based diagnosis. |
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Mathematical Analysis of COVID-19 Transmission Dynamics. A Case
Study with Nigeria |
Benedict, Agbata Celestine, Emmanuel, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
In this article, we formulated a mathematical model for the spread of the COVID-19 disease and we introduced quarantined
and isolated compartments. The next generation matrix method was adopted to compute the basic reproduction number in order to assess the transmission dynamics of the COVID-19 deadly disease. Stability analysis of the disease free equilibrium is investigated
based on the basic reproduction number and the result shows that it is locally and asymptotically stable for less than 1. Numerical calculation of the basic reproduction number revealed that which means that the disease can be eradicated from Nigeria. The
study shows that isolation, quarantine and other government policies like social distancing and lockdown are the best approaches to control the pernicious nature of COVID-19 pandemic. |
|
Bennett, D, De Vita, et al |
Ultrasound in Medicine and Biology |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The aim of the present study was to evaluate the possibilities of a portable pocket-sized ultrasound scanner in the
evaluation of lung involvement in patients with COVID-19 pneumonia. We conducted 437 paired readings in 34 LUS evaluations of hospitalized individuals with COVID-19. Fourteen scans were performed on individuals with severe cases, 11 on individuals with moderate
cases and nine on individuals with mild cases. No difference was observed between groups in days since onset of symptoms (23.29 ± 10.07, 22.91 ± 8.91 and 28.56 ± 11.13 d, respectively; p = 0.38). No significant differences were found between LUS scores obtained
with the high-end and the portable pocket-sized ultrasound scanner. LUS scores in individuals with mild respiratory impairment were significantly lower than in those with moderate and severe cases. |
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Time-related changes in sex distribution of COVID-19 incidence proportion in Italy |
Bianconi, V, Mannarino, et al |
Heliyon |
Epidemiology| Épidémiologie |
This study aimed to analyse time-related variation of sex-disaggregated COVID-19 incidence proportion (IP) in Italy
since March 9th to May 11th 2020, and to test its association with the frequency of swab testing for SARS-CoV-2. COVID-19 IP increased progressively in both sexes. Sex prevalence of COVID-19 IP reversed over time, with the M/F ratio of COVID-19 IP having passed
from 1,73 to 0,91. The mean number of daily swabs for RT-PCR SARS-CoV-2 test increased progressively until reaching a plateau in the last three weeks of the study period. The M/F ratio of COVID-19 IP inversely correlated with the number of daily swabs for
RT-PCR SARS-CoV-2 test (r = -0,87, p < 0.001), even after adjusting for the median age of COVID-19 cases (β = -0,66, p < 0,001). Time-related changes of sex distribution of COVID-19 IP in Italy are strongly influenced by the number of swabs testing for SARS-CoV-2. |
|
Biccard, Bruce, Miller, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objectives of this study were to determine resources, patient comorbidities and critical care interventions associated
with mortality in critically ill COVID-19 African patients. 1243 patients from 38 hospitals in six countries participated. The hospitals had a median of 2 (IQR 1-4) intensivists, with a nurse to patient ratio of 1:2 (IQR 1:3 to 1:1). Pulse oximetry was available
to all patients in 29/35 (82·9%) sites, and 21/35 (60%) of sites could provide dialysis or proning. The 30-day mortality following critical care admission was 54·7% (95% CI 51·9-57·6). Factors independently associated with mortality were an increasing age
(OR 1·04, 95% CI 1·02-1·05, p<0·001), a quick SOFA score of 3 (OR 3·61, 95% CI 1·41-9·24, p=0·01), increasing respiratory support defined as the need for continuous positive airway pressure (OR 5·86, 95% CI 1·47-23·35, p=0·01), invasive mechanical ventilation
(OR 16·42, 95% CI 4·52-59·65, p<0·001), three organ systems requiring support at admission (OR 5·52, 95% CI 1·13-27·01, p=0·04), cardiorespiratory arrest within 24 hours prior to admission (OR 4·43, 95% CI 1·01-19·54, p=0·05) and vasopressor requirements (OR
2·73, 95% CI 1·71-4·36, p<0·001). Human immunodeficiency virus was not associated with mortality (OR 1·84, 95% CI 0·99-3·40, p=0·05). |
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Early intervention is the key to success in COVID-19 control |
Binny, RachelleN, Baker, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
Here, we use a stochastic branching process model of COVID-19 transmission and control to simulate the epidemic trajectory
in New Zealand and the effect of its interventions during its COVID-19 outbreak in March-April 2020. We use the model to calculate key outcomes, including the peak load on the contact tracing system, the total number of reported COVID-19 cases and deaths,
and the probability of elimination within a specified time frame. We investigate the sensitivity of these outcomes to variations in the timing of the interventions. We find that a delay to the introduction of Alert Level 4 controls results in considerably
worse outcomes. Changes in the timing of border measures have a smaller effect. We conclude that the rapid response in introducing stay-at-home orders was crucial in reducing the number of cases and deaths and increasing the probability of elimination. |
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Agricultural workforce crisis in light of the COVID-19 pandemic |
Bochtis, D, Benos, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
The present study aims at assessing the COVID-19 pandemic impacts on agricultural labor and suggesting strategies to
mitigate them. The individual tasks associated with each occupation in agricultural production were evaluated on the basis of potential COVID-19 infection risk. The higher risk occupations within the sector were identified, which facilitates the allocation
of worker protection resources to the occupations where they are most needed. In particular, the results demonstrated that 50% of the agricultural workforce and 54% of the workers’ annual income are at moderate to high risk. |
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Bojadzic, Damir, Alcazar, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, we report the identification of SMIs of this PPI by screening our compound-library that is focused on the chemical
space of organic dyes. Among promising candidates identified, several dyes (Congo red, direct violet 1, Evans blue) and novel drug-like compounds (DRI-C23041, DRI-C91005) inhibited the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV
with low micromolar activity in our cell-free ELISA-type assays. Protein thermal shift assays indicated that the SMIs identified here bind SARS-CoV-2-S and not ACE2. Selected promising compounds inhibited the entry of a SARS-CoV-2-S expressing pseudovirus
into ACE2-expressing cells in concentration-dependent manner with low micromolar IC50s (6-30 μM). This provides proof-of-principle evidence for the feasibility of small-molecule inhibition of PPIs critical for coronavirus attachment/entry and serves as a first
guide in the search for SMI-based alternative antiviral therapies for the prevention and treatment of diseases caused by coronaviruses in general and COVID-19 in particular. |
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Clinical and Epidemiologic Analysis of COVID-19 Children Cases in Colombia PEDIACOVID |
Bolaños-Almeida, CE, Espitia Segura, et al |
Pediatr Infect Dis J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
OBJECTIVE: The COVID pandemic has affected Colombia with a high number of cases and deceases; however, no studies have
been published regarding pediatric population. An epidemiologic analysis of the nationwide COVID register, therefore, is necessary to outline and describe the impact in such population. METHODS: A retrospective analysis was made of the characteristics of a
cohort of 5062 patients <18 years of age, until June 16, 2020, reported at the National Institute of Health-INS through the national public access database, with all subjects confirmed with COVID-19 or severe acute respiratory syndrome-CoV-2. RESULTS: There
was a statistically significant difference between groups; age was statistically significantly higher in the asymptomatic, compared with: deceased, severe and moderate cases; moreover, age was statistically significantly higher in the mild, compared with:
deceased, severe and moderate. Post hoc analysis reveals significant differences between groups, the age of patients at home (9.39 years) and those recovered (9.3 years) being significantly higher than those in intensive care unit (4.9 years), in hospital
(6.1 years), or than the deceased (2.9 years). |
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Bordi, L, Sberna, et al |
Viruses |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Oral fluid (OF) is an alternate clinical sample, easy and safer to collect and could be useful for COVID-19 diagnosis,
monitoring viral load and shedding. METHODS: Optimal assay conditions and analytical sensitivity were established for the commercial Simplexa™ COVID-19 Direct assay adapted to OF matrix. The assay was used to test 337 OF and NPS specimens collected in parallel
from 164 hospitalized patients; 50 bronchoalveolar lavage (BAL) specimens from a subgroup of severe COVID-19 cases were also analysed. RESULTS: Using Simplexa™ COVID-19 Direct on OF matrix, 100% analytical detection down to 1 TCID50/mL were observed. No crossreaction
with other viruses transmitted through the respiratory toute was observed. Parallel testing of 337 OF and NPS samples showed highly concordant results, and high correlation of Ct values. Prolonged viral RNA shedding was observed up to 100 days from symptoms
onset (DSO), with 32% and 29% positivity observed in OF and NPS samples, respectively, collected between 60 and 100 DSO. |
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Borquaye, LS, Gasu, et al |
BioMed research international |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study, alkaloids from Cryptolepis sanguinolenta have been investigated for their ability to inhibit two of
the main proteins in SARS-CoV-2, the main protease and the RNA-dependent RNA polymerase, using in silico methods. Molecular docking was used to assess binding potential of the alkaloids to the viral proteins whereas molecular dynamics was used to evaluate
stability of the binding event. The results of the study indicate that all 13 alkaloids bind strongly to the main protease and RNA-dependent RNA polymerase. In particular, cryptomisrine, cryptospirolepine, cryptoquindoline, and biscryptolepine exhibited very
strong inhibitory potential towards both proteins. |
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Borroni, B, Gazzina, et al |
Neurol Sci |
Clinical data| Données cliniques |
In the present report, we described two Italian patients diagnosed with diaphragmatic myoclonus after COVID-19. In
both cases, mild lymphocytosis at cerebrospinal fluid analysis and no structural brain changes were reported. |
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Brito, CAA, Brito, et al |
Journal of infection in developing countries |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
We report an outbreak in 24 members of a family cluster during a period of social distancing. METHODOLOGY: We carried
out an observational descriptive study of a family cluster infected with SARS-CoV-2 in Pernambuco, Northeast Brazil. Laboratory confirmation included RT-PCR of nasopharyngeal samples or IgM or IgG serology. REULTS: The time of spread was 17 days from the first
case. All patients had mild symptoms, requiring no hospitalization, and none of them died. The frequency of symptomatic, laboratory-confirmed patients was higher among adults (94%) than among children (50%); the paediatric age group also had a higher frequency
of exposed individuals who remained negative for infection. This study highlights a high risk of intrahousehold transmission from an index case. |
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Smart technology for physical activity and health assessment during COVID-19 lockdown |
Buoite Stella, A, Ajčević, et al |
J Sports Med Phys Fitness |
Public Health response| Interventions de santé publique |
Assessment of physical activity levels should be encouraged to monitor and identify those at a higher risk of inactivity.
Smart technology is a promising tool to assess physical activity and health, and may be particularly useful during a period of general lockdown. METHODS: An online survey was developed and shared among the Italian general population to collect data about physical
activity and daily routine changes between January 2020 and the lockdown period from 23rd to 29th of March. Participants were asked to provide data such as daily step count (Steps) or heart rate (HR) measured and collected by their smart technology devices.
RESULTS: Four hundred participants were included in the final analysis. During the lockdown, the number of steps dropped from 8,284±4,390 to 3,294±3,994 steps (p< 0.001), while mean peak HR decreased from 61.3±18.2% to 55.9±17.3% (p< 0.001). |
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Burhan, E, Agustin, et al |
Acta medica Indonesiana |
Clinical data| Données cliniques |
Male, 55 years-old, with pneumonia caused by COVID-19. Discordance was found between patient's clinical status and
CXR lesion. On the 7th day of symptoms, patient was clinically well despite severe lesion shown on CXR. |
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Burke, KE, Kochar, et al |
Inflamm Bowel Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
We aimed to define the effect of targeted biologic and immunomodulator therapy on risk of COVID-19 in a multi-institutional
cohort of patients with inflammatory bowel disease (IBD). METHODS: We identified patients 18 years and older who received care for IBD at Partners Healthcare between January 2019 and April 2020. The primary outcome was development of COVID-19 defined as a
positive polymerase chain reaction test for severe acute respiratory syndrome coronavirus 2. Multivariable regression models were used to examine the effect of immunosuppression on risk of COVID-19 and its outcomes. RESULTS: In a cohort of 5302 IBD patients,
39 (0.7%) developed COVID-19. There was no difference in age, sex, or race between IBD patients with and without COVID-19. After adjusting for age, sex, race, and comorbidities, use of immunosuppressive therapy was not associated with an increased risk of
COVID-19. |
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C, SK, Kumar, et al |
Toxicology Reports |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The study aimed to validate the proficiency of nicotine binding with the soluble angiotensin-converting enzyme II receptor
(sACE2) with or without SARS-CoV-2 in the context of its binding affinity. Nicotine showed a profound binding affinity for the sACE2-INS1 complex than the sACE2 alone paving for the clinical trials to validate its therapeutic efficacy as a bitter compound
against the SARS-CoV-2 virulence. |
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Databiology Lab CORONAHACK: Collection of Public COVID-19 Data |
Caballero Perez, Juan, de Blas Perez, et al |
bioRxiv |
Public Health response| Interventions de santé publique |
To support and enable a collaborative response from the global research communities, we created a data collection for
different public sources for anonymized patient clinical data, imaging datasets, molecular data as nucleotide and protein sequences for the SARS-CoV-2 virus, reports of count of cases and deaths per city/country, and other economic indicators in Databiology
Lab. where researchers could access these data assets and use the hundreds of available open source bioinformatic applications to analyze them. |
|
Cai, Guoqi, Luo, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques Public health interventions*|
Interventions de santé publique |
This study aimed to evaluate the safety of reopening universities and colleges using a combined strategy in China.
Methods: This cross-sectional study included 13,116 staffs and postgraduate students who have returned to the four campuses of the University of Science and Technology of China from 17 February (students returned from 12 May) to 2 July 2020. The returning
to school was guided by a combined strategy including use of personal protective equipment, management of transportation, serological and nucleic acid tests for COVID-19, quarantine, and restrictions in and out of campus. . Findings: Among 13,116 participants,
4067 tested for SARS-CoV-2 nucleic acid and no positive results were identified. Of 9049 participants who chose to conduct antibody tests, 28 (0.3%) tested positive but no one was confirmed by the additional viral nucleic acid tests. High-risk exposures and
COVID-19 related symptoms were reported in 8.3% and 7.4% of participants, respectively. Comorbidities (hypertension, diabetes, chronic pulmonary disease, and chronic kidney disease) were rare (0.2%-1.5%). Interpretation: Using a combined strategy for COVID-19
prevention and control, safely reopening of universities and colleges in low-risk regions is possible and laboratory screening for SARS-CoV-2 infection may not be necessary. |
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Bacterial infections associated with COVID-19 in patients of the intensive
care unit |
Calzadilla, YA, Morales, et al |
Revista Cubana de Medicina Militar |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective: To describe the bacterial infections associated with COVID-19, in patients in an intensive care unit. Methods:
A descriptive study was carried out in the period from March 24 to May 24, 2020, in the intensive care unit of the Military Hospital "Comandante Manuel Fajardo Rivero". The study population consisted of 13 patients from 49 to 91 years. Results: 61.5% of the
patients were female, the mean age was 78.8 years, 61.5% died, and among these, 44.4% had coinfection. 66.7% and 55.6% of those with high blood pressure and ischemic heart disease, respectively, developed a coinfection. Escherichia coli was the most frequently
isolated microorganism. |
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Caplan, M, Goutay, et al |
Crit Care Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The present study assessed the effect of almitrine, a selective pulmonary vasoconstrictor, on arterial oxygenation
in severe acute respiratory syndrome coronavirus 2-induced acute respiratory distress syndrome. DESIGN: Single-center retrospective observational study. SETTING: ICU of Lille Teaching Hospital, France, from February 27, 2020, to April 14, 2020. PATIENTS: Patients
with coronavirus disease 2019 pneumonia confirmed by positive reverse transcriptase-polymerase chain reaction for severe acute respiratory syndrome-coronavirus 2 and acute respiratory distress syndrome according to Berlin definition. RESULTS: hirty-two patients
with acute respiratory distress syndrome received an almitrine infusion trial. In most cases, almitrine was infused in combination with inhaled nitric oxide (75%). Twenty-one patients (66%) were responders. The median PaO2/FIO2 ratio improvement was 39% and
differs significantly between the responders and nonresponders. The 28-day mortality rates were 47.6% and 63.6% for the responders and nonresponders, respectively. |
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32905639; Thrombolysis and bridging therapy in patients with acute ischaemic stroke and Covid-19 |
Cappellari, M, Zini, et al |
European Journal of Neurology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
We aimed to assess the 1-month outcome in ischaemic stroke patients with Covid-19 infection who received IVT alone
or before thrombectomy (bridging therapy). Methods: As a collaboration initiative promoted by the Italian Stroke Organization, all Italian stroke units (n = 190) were contacted and invited to participate in data collection on stroke patients with Covid-19
who received IVT. Results: Thirty patients received IVT alone and 17 received bridging therapy between 21 February 2020 and 30 April 2020 in 20 centers. t 1 month, 14 (30.4%) patients died and 20 (62.5%) survivors had a modified Rankin Scale (mRS) score of
3 to 5. At 24 to 36 hours, asymptomatic intracerebral hemorrhage (ICH) was reported in eight (17.4%) patients and symptomatic ICH (sICH) in two (4.3%) patients. Causes of death were severe ischaemic stroke (n = 8), a new ischaemic stroke (n = 2), acute respiratory
failure (n = 1), acute renal failure (n = 1), acute myocardial infarction (n = 1), and endocarditis (n = 1). In survivors with a 1‐month mRS score of 3 to 5, baseline glucose level was higher, whereas endovascular procedure time in cases of bridging therapy
was longer. |
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Cates, J, Lucero-Obusan, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To assess complications of COVID-19 and influenza, electronic health records (EHRs) from 3,948 hospitalized patients
with COVID-19 (March 1-May 31, 2020) and 5,453 hospitalized patients with influenza (October 1, 2018-February 1, 2020) from the national Veterans Health Administration (VHA), the largest integrated health care system in the United States,* were analyzed. Patients
with COVID-19 had almost 19 times the risk for acute respiratory distress syndrome (ARDS) than did patients with influenza, and more than twice the risk for myocarditis, deep vein thrombosis, pulmonary embolism, intracranial hemorrhage, acute hepatitis/liver
failure, bacteremia, and pressure ulcers. The percentage of COVID-19 patients who died while hospitalized (21.0%) was more than five times that of influenza patients (3.8%), and the duration of hospitalization was almost three times longer for COVID-19 patients. |
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Covid-19 forecasting in morocco using fbprophet facebook's framework in python |
Chafiq, T, Ouadoud, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study gives an indication of forecasting the spread of COVID-19 in the coming 4 months by Facebook Framework (FBprophet)
using in python. This study provides a trend mechanism as seen by FBprophet of pandemics of coronavirus (COVID-19) spread from 23th September 2020 to 21st January 2021, which can provide valuable insight for the national competent authorities |
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Serologic Responses in Healthy Adult with SARS-CoV-2 Reinfection, Hong Kong, August 2020 |
Chan, PKS, Lui, et al |
Emerg Infect Dis |
Clinical data| Données cliniques |
In March 2020, mild signs and symptoms of coronavirus disease developed in a healthy 33-year-old man in Hong Kong.
His first infection did not produce virus neutralizing antibodies. In August, he had asymptomatic reinfection, suggesting that persons without a robust neutralizing antibody response might be at risk for reinfection. |
|
Chávarri-Guerra, Y, Ramos-López, et al |
Oncologist |
Healthcare Response | Réponse des soins de santé |
We report the results of a multidisciplinary patient-navigator-led telemedicine supportive care program in Mexico City.
One-hundred sixty-three telemedicine interventions were provided to 45 patients (median age 68, 57% female). A quarter of the patients had less than or equal to elementary school education, and 15% lived in a rural area. The most common interventions were
psychological care (33%), pain and symptom control (25%), and nutritional counseling (13%). Half of the interventions were provided by video conferencing. The most common patient-reported barrier was limited experience using communication technology (). Our
results demonstrate the feasibility of providing supportive and palliative care interventions using telemedicine in resource-limited settings. |
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|
Chen, Chaolei, Li, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated whether pre-admission treatments for CMD may have impact on clinical outcomes in hospitalized COVID-19
patients. We conducted a retrospective cohort study of 1,525 COVID-19 patients admitted to two designated hospitals in Wuhan, China from January 21, 2020 to March 14, 2020. All medical records were reviewed to determine history of CMD and medications. The
primary endpoint was critical illness comprised of admission to ICU, mechanical ventilation, and use of extracorporeal membrane oxygenation (ECMO). Confirmed secondary endpoint was all-cause mortality. Compared with patients without CMD, those with CMD but
without treatment had a 3-fold increased risk of critical illness (OR, 3.13), and a 3-fold greater risk of death (HR, 3.08). Among those with CMD comorbidities, the pre-admission treatment for CMD was associated with significantly lower risk of developing
critical illness (OR, 0.28) and death (HR, 0.25). These findings were most salient in older patients (> 65 y). |
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Risk Factors and Predictive Scoring System Development for COVID-19 Death |
Chen, L, Chen, et al |
Chinese General Practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
This study aimed to investigate risk factors for COVID-19 death, and based on this, to develop a COVID-19 death predictive
scoring system. Two hundred and forty-five cases were included in the study and were divided into recovery group (n=212) and death group (n=33). Older age, lower SpO2, higher levels of BUN and PCT were independent risk factors for COVID-19 death, and the ASBP
scoring system developed based these factors might be available for the assessment of death risk of COVID-19. |
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Clinical Characteristics of COVID-19 Deaths in Wuhan:an Analysis of 2 231 Cases |
Cheng, L, Jiang, et al |
Chinese General Practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to analyze the clinical characteristics of 2 231 COVID-19 deaths in Wuhan, so as to provide information
for developing diagnostic and therapeutic projects and research of COVID-19. During January 9 to March 8, 2020, we collected the essential information and summary of medical records of 2 231 COVID-19 deaths from 66 hospitals in Wuhanwor15 districts. Data includes:
symptom onset time, first visit time, admission time, diagnosis time, death time, past history, clinical symptoms and treatment measures. Among the findings: Death cases mostly occurred in February.The average interval between the first symptom onset and
the first medical visit was(4.3±5.5)days, between the first symptom onset and hospitalization was(9.2±7.5)days, and between the first medical visit and confirmed diagnosis was(6.9±7.6)days. Of the 2 231 deaths, 65.67% were men. Underlying diseases were prevalent
in 76.56%) among which the top seven were hypertension, diabetes, heart disease, respiratory disease, cerebrovascular disease, chronic kidney disease, and malignant tumor. 52.58% were mechanically ventilated. 13.54% received renal replacement therapy. 12.68%
abandoned rescue. |
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First 100 Persons with COVID-19 - Zambia, March 18-April 28, 2020 |
Chipimo, PJ, Barradas, et al |
MMWR Morb Mortal Wkly Rep |
Clinical data| Données cliniques |
This article describes the detection of the first 100 COVID-19 cases in Zambia, through point-of-entry surveillance,
follow-up of suspect cases during quarantine, and contact-tracing. Persons with suspected COVID-19 were identified through various mechanisms, including port-of-entry surveillance, contact tracing, health care worker (HCW) testing, facility-based inpatient
screening, community-based screening, and calls from the public into a national hotline administered by the Disaster Management and Mitigation Unit and ZNPHI. |
|
Choi, E, Lee, et al |
Death studies |
Public Health response| Interventions de santé publique |
In response to the current COVID-19 pandemic, the Obsession with COVID-19 scale (OCS) and the Coronavirus Anxiety Scale
(CAS) were developed as screening tools for dysfunctional anxiety associated with the coronavirus. These scales have not yet been validated in the East Asia. The present study examined the validity of the OCS and the CAS with a sample of 329 Korean adults.
We found that the OCS-Korean and CAS-Korean showed good psychometric properties and construct validity. Developing such valid screening tools across different cultures is vital for health practitioners and scholars alike during global infectious disease outbreaks.
© 2020 Taylor & Francis Group, LLC. |
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Chow, JH, Khanna, et al |
Anesth Analg |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to evaluate whether aspirin use is associated with reduced risk of mechanical ventilation, ICU admission,
and in-hospital mortality. A retrospective, observational cohort study of adult patients admitted with COVID-19 to multiple hospitals in the United States between March 2020 and July 2020 was performed (n=412). Three hundred fourteen patients (76.3%) did not
receive aspirin, while 98 patients (23.7%) received aspirin within 24 hours of admission or 7 days prior to admission. After adjusting for 8 confounding variables, aspirin use was independently associated with decreased risk of mechanical ventilation (adjusted
HR 0.56), ICU admission (adjusted HR 0.57), and in-hospital mortality (adjusted HR 0.53). There were no differences in major bleeding (p=0.69) or overt thrombosis (p=0.82) between aspirin users and non-aspirin users. |
|
|
Chudasama, YoginiV, Zaccardi, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to use a multimorbidity index developed specifically for COVID-19 to investigate the association between multimorbidity
and risk of severe SARS-CoV-2 infection. We used data from the UK Biobank linked to laboratory confirmed test results for SARS-CoV-2 infection and mortality data from Public Health England between March 16 and July 26, 2020. By reviewing the current literature
on COVID-19 we derived a multimorbidity index including: 1) angina; 2) asthma; 3) atrial fibrillation; 4) cancer; 5) chronic kidney disease; 6) chronic obstructive pulmonary disease; 7) diabetes mellitus; 8) heart failure; 9) hypertension; 10) myocardial infarction;
11) peripheral vascular disease; 12) stroke. Potential effect modifiers of the association were assessed. Among 360,283 participants, the median age was 68 years, most were White (94.5%), and 1,706 had severe SARS-CoV-2 infection. The prevalence of multimorbidity
was more than double in those with severe SARS-CoV-2 infection (25%) compared to those without (11%), and clusters of several multimorbidities were more common in those with severe SARS-CoV-2 infection. The most common clusters with severe SARS-CoV-2 infection
were stroke with hypertension; diabetes and hypertension; and chronic kidney disease and hypertension. Multimorbidity was independently associated with a greater risk of severe SARS-CoV-2 infection (adjusted odds ratio 1.91) compared to no multimorbidity.
The risk remained consistent across potential effect modifiers, except for greater risk among men. |
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Supervised self-collected SARS-CoV-2 testing in indoor summer camps
to inform school reopening |
Cooch, PeterB, Watson, et al |
medRxiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
We hypothesized that supervised serial self-collected non-nasopharyngeal testing in summer camp settings would be acceptable
and feasible. Methods: We performed a cohort study at two urban day camps in San Francisco, for kindergarten-8th graders in June and July 2020. Eligible participants were campers, up to two adult household contacts, and camp staff. We assessed participation
rates for providing, at two time points, supervised, self-collected anterior nares samples for reverse transcription polymerase chain reaction (RT-PCR) and saliva samples for antibody testing. We qualitatively assessed testing feasibility and adherence to
stated camp infection mitigation strategies. Results: 76% (186/246) of eligible participants consented. The cohort completing both rounds of testing (n=163) comprised 67 campers, 76 household contacts, and 20 staff. Among those present, 100% of campers and
staff completed test collection at both time points. Testing was feasible to implement, including staff participation supervising camper test collection. No virus was detected by RT-PCR; seven participants had antibodies. Observed adherence to stated camp
mitigation policies for masking, physical distancing, and stable cohorting was generally high. |
|
SARS-CoV-2 antibodies in the Southern Region of New Zealand, 2020 |
Craigie, Alyson, McGregor, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Objectives: To evaluate the Abbott SARS-CoV-2 IgG nucleocapsid assay, alongside spike-based assays, and to determine
the frequency of antibodies among PCR-confirmed and probable cases, contacts, and higher risk individuals in the Southern Region of NZ.Results: The median time from infection onset to serum collection for PCR-confirmed cases was 14 weeks (range 11-17 weeks).
The Abbott assay demonstrated a specificity of 99.7% (95% CI, 98.2%-99.99%) and a sensitivity of 76.9% (95% CI, 66.0%-85.7%). Spike-based assays demonstrated superior sensitivity ranging 89.7-94.9%. Nine previously undiagnosed sero-positive individuals were
identified, and all had epidemiological risk factors. |
|
Cuong, HQ, Hai, et al |
BioMed research international |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We compared the ability to screen SARS-CoV-2 among three primer-probe sets in two different master mixes, Invitrogen™
SuperScript™ III One-Step RT-PCR and LightCycler Multiplex RNA Virus Master. Results: The assay with TIB-Molbiol, IDT, and Phu Sa sets for LightCycler Multiplex RNA Virus Master or Invitrogen™ SuperScript™ III One-Step RT-PCR showed positive results from a
single reaction of triplicate in the three days of 4.8 copies per reaction. R squared and amplification efficiency were 0.97 and ranged from 107 to 108%, respectively. Conclusions: Our findings indicated that TIB-Molbiol, IDT, and Phu Sa primer-probe sets
could be beneficial for the laboratory screening of SARS-CoV-2 by RT-qPCR assay of E gene. There is a need to consider the combination of these reagent sets as a new strategy to increase the testing capacity of screening programs for COVID-19. |
|
|
Dahab, MA, Hegazy, et al |
Nat Prod Bioprospect |
Therapeutics| Thérapeutique |
Total 40 natural compounds were selected to perform the molecular docking studies to screen and identify the potent
antiviral agents specifically for SARS-CoV-2. The key targets of COVID-19, protease (PDBID: 7BQY) and RNA polymerase (PDBID: 7bV2) were used to dock our target compounds by Molecular Operating Environment (MOE) version 2014.09. We used 3 different conformations
of protease target (6M0K, 6Y2F and 7BQY) and two different score functions to strengthen the probability of inhibitors discovery. After an extensive screening analysis, 20 compounds exhibit good binding affinities to one or both COVID-19 targets. 7 out of
20 compounds were predicted to overcome the activity of both targets. The top 7 hits are, flacourticin (3), sagerinic acid (16), hordatine A (23), hordatine B (24), N-feruloyl tyramine dimer (25), bisavenanthramides B-5 (29) and vulnibactins (40). According
to our results, all these top hits was found to have a better binding scores than remdesivir, the native ligand in RNA polymerase target (PDBID: 7bV2). |
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Danchin, Antoine, Pagani-Azizi, et al |
medRxiv |
Coronavirology| Coronavirologie Immunology | Immunologie |
The interplay between the virus, infected cells and the immune ressponses to SARS-CoV-2 is still under debate. Extending
the basic model of viral dynamics we propose here a formal approach to describe the neutralizing versus non-neutralizing scenarios and compare with the possible effects of antibody-dependent enhancement (ADE). The theoretical model is consistent with data
available from the literature and conclusions show that, while both non-neutralizing scenarios and ADE give rise to similar final virus clearance, the non-neutralizing antibodies can induce permanent high levels of antibody production with documented unfavorable
impact on the disease progression and outcome. We also discuss the implications on secondary infections. |
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|
Daniel, Pinto, Cirnes, et al |
BioMed research international |
Healthcare Response | Réponse des soins de santé |
This article describes the workflow changes that were implemented to a molecular pathology laboratory, a national reference
center, to maximize safety and productivity. We assess the impact this situation had on our caseload and what conclusions can be drawn about the wider impact of the pandemic in oncological therapy in Portugal. We reviewed our database for all oncological molecular
tests requested between March and April of 2019 and 2020. For each case, we recorded age, sex, region of the country, requesting institution, sample type, testing method, and turnaround time (TAT). A comparison between years was made. Conclusions: Case reduction
was observed at hospitals that have mostly been involved in the treatment of COVID-19 and in the north of the country, the region worst-hit by the pandemic. Similar to other studies, our TAT decreased, even with a similar number of routine cases. |
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|
Darnindro, N, Nurdewati, et al |
Acta medica Indonesiana |
Clinical data| Données cliniques |
The present case report describes a patient who came with a complaint of diarrhea without fever and she was later confirmed
to be positive for COVID-19 during hospitalization. The presence of unspecified initial symptoms calls for greater vigilance from health workers in establishing diagnosis patients with COVID-19. |
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|
Dasgupta, S, Bowen, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie |
County-level data on COVID-19 cases during June 1-July 25, 2020 and from the 2018 CDC social vulnerability index (SVI)
were analyzed to examine associations between social vulnerability and hotspot detection and to describe incidence after hotspot detection. Areas with greater social vulnerabilities, particularly those related to higher representation of racial and ethnic
minority residents (RR = 5.3; 95% CI = 4.4-6.4), density of housing units per structure (RR = 3.1; 95% CI = 2.7-3.6), and crowded housing units (i.e., more persons than rooms) (RR = 2.0; 95% CI = 1.8-2.3), were more likely to become hotspots, especially in
less urban areas. Among hotspot counties, those with greater social vulnerability had higher COVID-19 incidence during the 14 days after detection (212-234 cases per 100,000 persons for highest SVI quartile versus 35-131 cases per 100,000 persons for other
quartiles). |
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|
Davico, C, Marcotulli, et al |
Seizure |
Healthcare Response | Réponse des soins de santé |
This study evaluated trends in emergency department (ED) access for seizure-related reasons in the first 8 weeks of
lockdown in Italy. During the COVID-19 lockdown period (February 23-April 21, 2020), there was a 72 % decrease in all pediatric ED accesses over the corresponding 2019 period (n = 3,395 vs n = 12,128), with a 38 % decrease in seizure-related accesses (n =
41 vs n = 66). The observed decrease of seizure-related ED accesses was not accompanied by significant changes in age, sex, type of seizure, or hospitalization rate after the ED visit. |
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|
Davidson, N, Evans, et al |
Pathology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study examined the performance of three laboratory based serological assays, EUROIMMUN Anti-SARS-CoV-2 IgA/IgG,
MAGLUMI 2000 Plus 2019-nCov IgM/IgG and EDI Novel Coronavirus (COVID-19) IgM/IgG immunoassays. We evaluated 138 samples from a reference non-infected population and 71 samples from a cohort of 37 patients with SARS-CoV-2 confirmed positive by RT-PCR. The samples
were collected at various intervals of 0–45 days post symptoms onset (PSO). Among the findings: Specificity and sensitivity of these assays was 60.9%/71.4% (IgA) and 94.2%/63.3% (IgG) for EUROIMMUN; 98.5%/18.4% (IgM) and 97.8%/53.1% (IgG) for MAGLUMI; and
94.9%/22.5% (IgM) and 93.5%/57.1% (IgG) for EDI, respectively. When samples collected ≥14 days PSO were considered, the sensitivities were 100.0 and 100.0%; 31.0 and 82.8%; 34.5 and 57.1%, respectively. When samples collected ≥14 days PSO were considered,
the sensitivities were 100.0 and 100.0%; 31.0 and 82.8%; 34.5 and 57.1%, respectively. Using estimated population prevalence of 0.1, 1, and 10%, the positive predictive value of all assays remained low. |
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Modeling and optimal control analysis of transmission dynamics of COVID-19: The case of Ethiopia |
Deressa, CT, Duressa, et al |
Alexandria Engineering Journal |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
A mathematical model to estimate transmission dynamics of COVID-19 is developed. A real data of confirmed cases for
Ethiopia is used for parameter estimation via model fitting. Results showed that, the diseases free and endemic equilibrium points are found to be locally and globally asymptotically stable for Ro 1 respectively. The basic reproduction number is Ro = 1.5085.
Optimal control analysis also showed that, combination of optimal preventive strategies such as public health education, personal protective measures and treatment of hospitalized cases are effective to significantly decrease the number of COVID-19 cases in
different compartments of the model. © 2020 Faculty of Engineering, Alexandria University |
|
Clinical correlations of SARS-CoV-2 antibody responses in patients with COVID-19
infection |
DeSimone, Mia, Simmons, et al |
medRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
This study was an observational cohort study to evaluate antibody responses in individuals with PCR-confirmed COVID-19,
including 48 hospitalized patients diagnosed with COVID-19 by real-time polymerase chain reaction (RT-PCR) at a large tertiary care medical center. Antibody production reflects the virus-specific immune response, which is important for immunity but also drives
pathology, and antibody levels may be important for guiding treatment of individuals with COVID-19. |
|
Dewar, B, Anderson, et al |
PLoS One |
Healthcare Response | Réponse des soins de santé |
Authors sought to explore Canadian physicians' preparedness and attitudes regarding resource allocation decisions.
This rapidly implemented survey suggests that a sample of Canadian physicians feel underprepared to make resource allocation decisions, and desire both more emotional support and clear, transparent, evidence-based policy. |
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Dhanalaxmi, Sirigireddy, Agarwal, et al |
arXiv |
Public Health response| Interventions de santé publique |
Social media such as Twitter is a hotspot of user-generated information. In this ongoing Covid-19 pandemic, there has
been an abundance of data on social media which can be classified as informative and uninformative content. In this paper, we present our work to detect informative Covid-19 English tweets using RoBERTa model as a part of the W-NUT workshop 2020. We show the
efficacy of our model on a public dataset with an F1-score of 0.89 on the validation dataset and 0.87 on the leaderboard. |
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33027455; Is the COVID-19 disease associated with de novo nephritic syndrome? |
Dheir, H, Sipahi, et al |
Revista da Associacao Medica Brasileira (1992) |
Clinical data| Données cliniques |
This study aims to determine the incidence of de novo nephritic syndrome (NS) in COVID-19 patients and identify its
associated factors. COVID-19-induced de novo nephritic syndrome may occur mainly due to tubulointerstitial involvement and often results in spontaneous remission. |
|
Dimeglio, C, Herin, et al |
Journal of Infection |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé Immunology
| Immunologie |
In this letter to the editor, authors aimed to determine the serological status of HCW after the first wave of the
epidemic, and the extent of their protective immunity. Transmission could be reduced by enhancing infection prevention training and communication within hospitals, particularly in units with little or no exposure to the virus and by introducing audits of hygiene
practices. |
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|
Do, C, Vu, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study aims to investigate an automated approach using Convolutional Neural Network (CNN) to efficiently classify
COVID-19 cases vs healthy cases using chest CT images. Authors concluded that a CNN approach can detect COVID-19 using CT features, and DenseNet201is the highest performing model. |
|
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Dutta, K, Mukherjee, et al |
Biological Rhythm Research |
Public Health response| Interventions de santé publique |
An online survey was conducted to comprehend the effect of lockdown on sleep behavior and screen exposure time on school
children. These baseline data on sleep parameters and duration of exposure to the screen will help us in devising approaches to mitigate the evident disruption this unprecedented phase has brought about. |
|
|
Edjoc, R, Atchessi, et al |
Can J Public Health |
Epidemiology| Épidémiologie |
The objective of this study was to compare a mathematical tool and time-dependent reproduction number (Rt) estimates
to assess the COVID-19 pandemic progression in a Canadian context. This analyses compared a mathematical tool to R(t) estimates to ascertain the status of the pandemic in Canada. |
|
|
Elena, AM, Silvia, et al |
Lupus |
Clinical data| Données cliniques |
In this letter to the editor authors discuss the case of a young female with a history of systemic lupus erythematosus
(SLE) and antiphospholipid antibodies (aPL) who developed pulmonary thromboembolism coinciding with COVID-19. |
|
|
Fagiolo, Giorgio |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
A mathematical tool and time-dependent reproduction number (Rt) estimates to assess the COVID-19 pandemic progression
in a Canadian context. For Canada as a whole, the testing graphs had a slightly concave profile and a coincident decrease in Rt estimates. Saskatchewan more recently had a convex profile with a gradual shift to a concave profile and also demonstrated a gradual
decline in Rt estimates. Curves and Rt estimates for Alberta, British Columbia, Manitoba, Nova Scotia, Ontario and Quebec displayed a gradual shift towards concavity over time and an overall decrease in Rt estimates, which is suggestive of a positive impact
of public health interventions implemented federally and provincially. |
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Promoting Social Distancing in a Pandemic: Beyond the Good
Intentions |
Falco, Paolo, Zaccagni, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
Authors conducted a randomised trial with a large sample of Danish residents to test different versions of a reminder
to stay home at the peak of the crisis. Findings show that reminders can be useful to protect groups at risk by increasing their own compliance with social distancing. |
|
Faucher, Samuel, Lundberg, et al |
arXiv |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Authors introduce a new virucidal face mask concept based on a reverse-flow reactor driven by the oscillatory flow
of human breath. This study is the first quantitative analysis of virucidal thermal inactivation within a protective face mask and addresses a pressing need for new approaches for personal protective equipment during a global pandemic. |
|
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Implementation of online learning during the covid-19 pandemic on Madura Island, Indonesia |
Febrianto, PT, Mas'udah, et al |
International Journal of Learning, Teaching and Educational Research |
Public Health response| Interventions de santé publique |
This study aimed to determine the online learning process and the associated obstacles experienced by students. The
availability of supporting facilities and infrastructure as well as the facilitated internet access among rural communities, financial assistance and the socialisation of the importance of online learning is necessary. |
|
Clinical characterization of obstetric patients with suspected covid-19 |
Fernández, ABS, Cid, et al |
Revista Cubana de Medicina Militar |
Clinical data| Données cliniques |
The objective of this study was to clinically characterize obstetric patients with suspected COVID-19. COVID-19 occurred
more frequently in pregnant women during the first trimester, the mild form of the disease prevailed, with no COVID-19 pneumonia or deaths from this disease. |
|
Fieldhouse, JK, Bailey, et al |
Tropical Diseases, Travel Medicine and Vaccines |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The study team sought to compare real-time assay results with panspecies conventional molecular diagnostics to compare
sensitivities and learn if novel viruses had been missed. The observed differences in the two modes of amplification suggest that where a problem with sensitivity is suspected, real-time assay results might be supplemented with panspecies conventional PCR/RT-PCR
assays. |
|
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33032685; Cutaneous Manifestations of COVID-19: A Report from the United Arab Emirates |
Galadari, I, Marzooqi, et al |
Skinmed |
Clinical data| Données cliniques |
A retrospective case series based on history and clinical findings was performed across six hospitals in the UAE, including
two field hospitals. The occurrence of other cutaneous manifestations with an underlying autoimmune pathogenesis should raise the possibility of such conditions in those with COVID-19. |
|
Gale, J, Clark, et al |
Canadian Journal of Kidney Health and Disease |
Clinical data| Données cliniques |
The objective of this study was to describe the clinical characteristics, symptom burden, and COVID-19 status in a
cross-section of hemodialysis patients residing in areas with evidence of community spread. In this study of hemodialysis patients residing in areas with community spread who otherwise did not meet symptom criteria for being “at-risk,” we did not identify
any individual who tested positive for SARS-CoV-2. |
|
|
Gao, Wayne, Sanna, et al |
SSRN- Lancet prepublication |
Public health interventions*| Interventions de santé publique Public Health response|
Interventions de santé publique |
Taiwan has successfully contained the COVID-19 outbreak, the authors' goal was to assess whether non-pharmaceutical
interventions and behavioral changes affected all- and other causes of death. COVID-19 interventions may have prevented the spread of other respiratory infectious diseases and resulted in fewer than expected deaths in Taiwan. |
|
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Cardiac Tamponade in a Patient With Myocardial Infarction and COVID-19: Electron Microscopy |
García-Cruz, E, Manzur-Sandoval, et al |
JACC: Case Reports |
Clinical data| Données cliniques |
We present the case of a patient with myocardial infarction and COVID-19 disease who developed hemorrhagic pericardial
effusion and cardiac tamponade. The differential diagnosis included post-infarction pericarditis and mechanical complications, thrombolysis, Dressler syndrome, and viral pericarditis. The histopathologic examination of the pericardial tissue sample and electron
microscopic examination established the diagnosis. (Level of Difficulty: Advanced.) © 2020 The Authors |
|
Fetal Transient Skin Edema in Two Pregnant Women With Coronavirus Disease 2019 (COVID-19) |
Garcia-Manau, P, Garcia-Ruiz, et al |
Obstet Gynecol |
Clinical data| Données cliniques |
Authors discuss 2 patients where fetal skin edema was observed on ultrasound examination while maternal SARS-COV-2
RT-PCR test results were positive and resolved when maternal SARS-COV-2 RT-PCR test results became negative. Transient fetal skin edema noted in these two patients with COVID-19 in the second trimester may represent results of fetal infection or altered fetal
physiology due to maternal disease or may be unrelated to the maternal illness. |
|
Race, Ethnicity, and Age Trends in Persons Who Died from COVID-19 -
United States, May-August 2020 |
Gold, JAW, Rossen, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Surveillance |
Analysis of 114,411 COVID-19–associated deaths reported to National Vital Statistics System during May–August 2020,
found that 51.3% of decedents were non-Hispanic White, 24.2% were Hispanic or Latino (Hispanic), and 18.7% were non-Hispanic Black. The percentage of Hispanic decedents increased from 16.3% in May to 26.4% in August. |
|
González-Díaz, A, Abad-López, et al |
Actas Urologicas Espanolas |
Healthcare Response | Réponse des soins de santé |
Our objective is to describe the outcomes presented by patients undergoing surgery in the urology department of a tertiary
hospital, across the pandemic phases. 103 urological surgeries were performed, and 11 patients were diagnosed with COVID-19. The diagnosis was already known in 1 patient, while the other 10 developed the disease in an average of 25 days after the intervention
and 16,6 days after discharge. Of seven transplant patients, four got the infection. Three deaths were recorded due to the disease. |
|
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Adaptive Mesh Refinement and Coarsening for Diffusion-Reaction Epidemiological Models |
Grave, Malú, Coutinho, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Transmission |
In this work, we extend the formulation of SEIRD compartmental models to diffusion-reaction systems of partial differential
equations to capture the continuous spatio-temporal dynamics of COVID-19. Since the virus spread is not only through diffusion, we introduce a source term to the equation system, representing exposed people who return from travel. We also add the possibility
of anisotropic non-homogeneous diffusion. We implement the whole model in \texttt{libMesh}, an open finite element library that provides a framework for multiphysics, considering adaptive mesh refinement and coarsening. Therefore, the model can represent several
spatial scales, adapting the resolution to the disease dynamics. We verify our model with standard SEIRD models and show several examples highlighting the present model's new capabilities. |
|
Grewal, VS, Sharma, et al |
Medical Journal Armed Forces India |
Public Health response| Interventions de santé publique |
This study was conducted to assess knowledge, attitudes, practices, and behavior regarding COVID-19 among serving soldiers.
A total of 1231 serving personnel participated in an online survey. The prevalence of correct knowledge was more than 80%. A statistically significant association was found with increasing age and education. 81.38% thought that the response measures were
adequate. In the affective domain, increased perception of anxiousness, worriedness, and not feeling relaxed was found in the responses. |
|
|
Grippo, Francesco, Navarra, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie |
Aim of the present study was to examine death certificates of persons who tested positive for severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). A total of 5,311 death certificates of persons dying in March through May 2020 were analysed. COVID-19 was the underlying cause of death in 88% of cases. Pneumonia and respiratory failure were the most common complications,
being identified in 78% and 54% of certificates, respectively. Comorbidities were reported in 72% of certificates, with little variation by age and gender. The most common comorbidities were hypertensive heart disease, diabetes, ischaemic heart disease, and
neoplasms. |
|
|
Multisystem inflammatory syndrome in SARS-CoV-2 infection
mimicking acute appendicitis in children |
Guanà, R, Pagliara, et al |
Pediatrics and Neonatology |
Clinical data| Données cliniques |
A 7 years old boy with no known comorbidities was presented to our attention with complaints of low-grade fever and
conjunctivitis for 5 days. Time Reverse Transcription Polymerase Chain Reaction (RT-PCR) test for SARS-CoV-2 infection was negative. During the first night as inpatient, he underwent sudden hypoxia (oxygen saturation <85%) and hypotension, with a systolic
blood pressure of 80 mmHg. He was transferred to the Intensive Care Unit. The specialist (endocrinologist) suggested a multisystem inflammatory syndrome in children (MIS-C). Due to the atypical features, he underwent two SARS-Cov-2 tests (RT-PCR) (both negative)
and one dosage of seric Immunoglobulin G (IgG) for SARS-Cov-2 (positive). |
|
Guo, J, Xie, et al |
Disaster Med Public Health Prep |
Healthcare Response | Réponse des soins de santé |
METHODS: In this paper, we outline several measures designed to prevent COVID-19 in dental treatments, such as three-level
pre-examination triage and two-body temperature tests, three-level protection for medical personnel, gargle before oral treatment, implement the four-hand operation, suctioning saliva during oral treatment, use a rubber dam, strict enforcement of hand hygiene.
RESULTS: The epidemic has been brought under control and routine oral examination and treatments have gradually been resumed from March 9, 2020, in Hunan province, China. From January 24, 2020, to March 8, 2020, a total of 4,272 patients received oral therapy
during the COVID-19 epidemic in our hospital. |
|
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A profile of a retrospective cohort of 22 patients of COVID-19
with active/treated tuberculosis |
Gupta, N, Ish, et al |
Eur Respir J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
According to the authors, this study describes the first-ever cohort of current or treated TB patients co-infected
with COVID-19 from a high TB burden country, recruited by a tertiary care hospital in India. |
|
Gupta, S, Kaushik, et al |
Monaldi Archives for Chest Disease |
Epidemiology| Épidémiologie |
We report our experience of management and outcomes of hospitalized patients with COVID-19 at a large tertiary-care
center in Midwestern United States. Of 658 patients presenting to our tertiary care center, 217 needed hospitalization, majority (77%) of whom were severely sick requiring admission to the intensive care unit (ICU). All received corticosteroids, and 78% of
the patients received tocilizumab. More than two-thirds of the patients received anticoagulation and 80% of patients in the ICU had prone-positioning. The median duration of hospitalization was 12 days (interquartile range, 8 to16), median duration of intensive
care unit stay was 7 days (interquartile range, 5 to 9) and requirement of mechanical ventilation was 6 days (interquartile range, 5 to 8) in our cohort. Of the 217 patients, 27 died (12% mortality). |
|
|
Gyebi, GA, Adegunloye, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Hence, 97 alkaloids from African medicinal plants with reported antiviral activity were evaluated for this purpose
via in silico studies. These alkaloids were docked for their interactions with SARS-CoV-2 spike glycoprotein, ACE2, and TMPRSS2. Top 20 alkaloids with highest binding affinities were further screened for their interactions with spike glycoprotein of SARS-CoV
and MERS-CoV, and with ACE2-SARS-CoV-2 receptor-binding domain complex (ACE2-RBD). Results revealed that more than 15 alkaloids interacted better than the reference compounds. 10–Hydroxyusambarensine and Cryptospirolepine were docked in a similar binding
pattern to the S1-specificy pocket of TMPRSS2 as camostat. The strong binding affinities, stability of the alkaloid-protein complexes and amino acid interactions displayed by cryptospirolepine, 10-hydroxyusambarensine, and cryptoquindoline with important binding
hotspots of the proteins suggest these alkaloids have the potential of altering the capacity of SARS-CoV-2 membrane mediated host cell entry. |
|
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‘When will I be free’: Lessons from COVID-19 for Child Protection in South Africa |
Haffejee, S, Levine, et al |
Child Abuse and Neglect |
Public Health response| Interventions de santé publique |
Objective: The aim of this study was to explore the experiences and impact of the pandemic and the resulting social
isolation on the wellbeing and protection of children living in a residential care facility. Methods and participants: We used qualitative, participatory approaches – specifically draw-and-write methods – to engage with 32 children (average age = 13.5 years)
living in a residential care facility in Gauteng. Findings: Children in care demonstrated an awareness of the socio-economic difficulties facing communities in South Africa, and shared deep concerns about the safety, well-being and welfare of parents and siblings.
Although they expressed frustration at the lack of contact with family members, they acknowledged the resources they had access to in a residential care facility, which enabled them to cope and which ensured their safety. |
|
Haji Esmaeil Memar, E, Mamishi, et al |
Archives de Pediatrie |
Clinical data| Données cliniques |
We report a pediatric case of fulminant hepatic failure associated with COVID-19. Although the patient was treated
for acute fulminant hepatic failure in the context of COVID-19, he died following the progression of the disease to stage 4 hepatic failure with encephalopathy and brain death. |
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|
Hansen, EF, Bech, et al |
European Clinical Respiratory Journal |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We aimed to determine if closed-loop control of oxygen was feasible in patients with COVID-19 and could maintain SpO2
in the specified interval. Fifteen patients (six women, nine men) participated in the study. he average stay on the ward was 3.2 days and O2matic was used on average for 66 hours, providing 987 hours of observation. O2matic maintained SpO2 in the desired interval
for 82.9% of the time. Time with SpO2 > 2% below interval was 5.1% and time with SpO2 > 2% above interval was 0.6%. Closed-loop control of oxygen to patients with COVID-19 is feasible and can maintain SpO2 in the specified interval in the majority of time.
Closed-loop automated control could be of particular benefit for patients in isolation with decreased visibility, surveillance and monitoring. |
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|
Harris, RossJ, Whitaker, et al |
medRxiv |
Epidemiology| Épidémiologie Immunology | Immunologie |
We undertook prospective serosurveillance in a large cohort of healthy adults from the start of the epidemic in England.
In total, 2247 individuals were recruited and 2014 (90%) had 3-5 monthly antibody tests. Over the study period SARS-CoV-2 seropositivity was 8-10% overall and up to 21% in clinical healthcare workers. In seropositive individuals, nucleoprotein and spike protein
IgG antibodies declined with time after infection and 50% are predicted to fall below the positive test threshold after 6 months. |
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Article Current Status of Nosocomial COVID-19 Cases in Delivery Facilities in Japan |
Hasegawa, Junichi, Arakaki, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé |
We aimed to identify the characteristics of and measures taken by Japanese medical facilities providing maternity services
that have recorded cases of nosocomial infection with SARS-CoV-2. A case-control study was conducted by including medical facilities with (Cases) and without (Control) nosocomial COVID-19. Responses from 1,418 medical facilities were assessed (65% of all
delivery facilities in Japan). Seventy-five COVID-19-positive pregnant women were treated in 48 facilities. Nosocomial infection was reported in 4.1% of the facilities. Nine patients developed a nosocomial infection in the maternity ward or obstetric department.
Variables that contributed to nosocomial COVID-19 were chest CT on admission, PCR test for SARS-CoV-2 before delivery, transfer of pregnant women with fever to another hospital, and private clinics. |
|
Hashemi, SA, Golab Behbahan, et al |
Biosensors and Bioelectronics |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Fast transferable pathogens requiring practical diagnostic setups to control their transfer chain and stop sever outbreaks
in early stages of their appearance. Herein, we have addressed this urgent demand by designing a rapid electrochemical diagnostic kit composed of fixed/screen printed electrodes that can detect pathogenic viruses such as SARS-CoV-2 and/or animal viruses through
the differentiable fingerprint of their viral glycoproteins at different voltage positions. The method do not require any extraction and/or biomarkers for detection of target viruses and can identify trace of different pathogenic viruses in about 1 min. The
nanosensor also demonstrated superior limit of detection (LOD) and sensitivity of 1.68 × 10−22 μg mL−1 and 0.0048 μAμg.mL−1. cm−2, respectively, toward detection of SARS-CoV-2 in biological media, while blind clinical evaluations of 100 suspected samples furtherly
confirmed the superior sensitivity/specificity of developed nanosystem toward rapid identification of ill people even at incubation and prodromal periods of illness. |
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|
Hassaniazad, M, Inchehsablagh, et al |
Trials |
RCT |
Objectives: To investigates the effectiveness of curcumin-containing Nanomicelles as a therapeutic supplement in the
treatment of patients with COVID-19 and its effect on immune responses balance changes following treatment. |
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Hernández-Vásquez, A, Gamboa-Unsihuay, et al |
Medwave |
Epidemiology| Épidémiologie |
Objective: To compare excess mortality by district quintiles according to the Human Development Index (HDI) in Metropolitan
Lima, the capital of Peru, and analyze the socioeconomic factors associated with excess mortality within the context of COVID-19. An excess of 20 093 non-violent deaths and 2,979 confirmed deaths from COVID-19 were registered in Metropolitan Lima during the
study period. The increase was observed primarily in men and adults aged 60 and over. Residents in the districts belonging to the fifth quintile, according to HDI, presented, in most cases, the lowest rates. Multivariate analysis revealed that a higher HDI
level (p = 0.009) and a higher proportion of inhabitants living in extreme poverty (p = 0.014) decreased the excess mortality. |
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|
Hidayat, R, Aini, et al |
Acta medica Indonesiana |
Public health interventions*| Interventions de santé publique Healthcare Response |
Réponse des soins de santé |
This study aimed to evaluate the 3T (test, trace, and treatment) strategy to control COVID-19 infection in a COVID-19
Referral Hospital in Depok, West Java, Indonesia. The study was conducted in June 2020 with 742 participants (staff members) using secondary data from polymerase chain reaction (PCR) test results. the PCR test results were positive in 83 (11.1%) participants,
with a case-per-tracing ratio of 1:24 and 1:2 in the first and third phases of tracing, respectively. The COVID-19 case graph for the participants decreased along with the implementation of the 3T strategy. The positivity rate in the first phase of tracing
was 20% and decreased to 5% in the third phase of tracing. Staff with confirmed positive test results were advised to isolate themselves (hospital or self-isolation). Hospital isolation was found to be associated with the duration of PCR test conversion (p<0.001). |
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32618968; Early comprehensive testing for COVID-19 is essential to protect trauma centers |
Hu, P, Jansen, et al |
Journal of Trauma and Acute Care Surgery |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
We discuss the impact that SARS-CoV-2 has had in our trauma center and our steps to limit the potential exposures.
Over the 14-day evaluation period, we tested 85 trauma patients for SARS-CoV-2 infection, and 21 (25%) were found to be positive. Sixty percent of the patients in the trauma/burn intensive care unit were infected with SARS-CoV-2. Positive verbal screen results,
presence of ground glass opacities on admission chest CT, and presence of clinical symptoms were not significantly different in patients with or without SARS-CoV-2 infection (p > 0.05). Many infected patients were without clinical symptoms (9/21, 43%) or radiological
signs on admission (18/21, 86%) of COVID-19. |
|
Hukic, M, Ponjavic, et al |
Bosn J Basic Med Sci |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Demographic and clinical information on all the cases along with exposure and contact information was collected using
a standardized case report form. In suspected SARS-CoV-2 cases, respiratory specimens were collected and tested by real-time reverse-transcriptase polymerase chain reaction (rRT-PCR) assay. The dynamic of the outbreak was summarized using epidemiological
curves, instantaneous reproduction number Rt and interactive choropleth maps for geographical distribution and spread. The rate of hospitalization was 14.0 % (790/5646) in Federation of Bosnia and Herzegovina (FBH) and 6.2 % (267/4299) in Republic of Srpska
(RS). The death rate was 2.2% (122/5646) in FBH and 3.6% in the RS (155/4299). After the authorities lifted mandatory quarantine restrictions, the basic reproduction number increased from 1.13 on May, the 20th to 1.72 on May the 31st. The outbreak concerns
both entities, Federation of Bosnia and Herzegovina and Republika Srpska, and it is more pronounced in those aged 20-44 years. |
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Stochastic mathematical model for the spread and control of Corona virus |
Hussain, S, Zeb, et al |
Advances in Difference Equations |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
To understand the spread and control of corona virus in a better way, we first study the stability of the corresponding
deterministic model, investigate the unique nonnegative strong solution and an inequality managing of which leads to control of the virus. After this, we pass to the stochastic model and show the existence of a unique strong solution. Next, we use the supermartingale
approach to investigate a bound managing of which also leads to decrease of the number of infected individuals. Finally, we use the data of the COVOD-19 in USA to calculate the intensity of Poisson processes and verify our results. |
|
A Biomarker Based Severity Progression Indicator for COVID-19: The Kuwait Prognosis Indicator
Score |
Jamal, MH, Doi, et al |
Biomarkers |
Modelling/ prediction| Modélisation/prédiction Clinical data| Données cliniques |
We developed and validated a simple score calculated at time of diagnosis that can predict patients with severe COVID-19.
The KPI score calculator is now available online. |
|
James, MK, Kishore, et al |
J Community Health |
Epidemiology| Épidémiologie |
The aim of this study is to describe the demographics and socioeconomic factors in relation to geolocation of COVID-19
patients. COVID-19 disproportionately affected minorities and males. |
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|
Jia, Hong-Ling, Li, et al |
SSRN- Lancet prepublication |
Transmission Coronavirology| Coronavirologie |
In China viral variants in overseas travelers were usually shared within households but not among passengers on the
same flight. From 109 imported cases we found diverse viral variants distributing in the global viral phylogeny, which were usually shared within households but not among passengers on the same flight. Local transmission was predominately attributed to two
specific variants imported from Africa, including the local cases who reported no direct/indirect contact with imported cases. |
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Jin, Z, Zhao, et al |
Frontiers in Public Health |
Public Health response| Interventions de santé publique |
Chinese survey of adults of high-risk and low-rick areas to measure adoption of preventive behaviors, appraisal of
risk communication, anxiety level, and susceptibility to emotional contagion. The results demonstrated reciprocal negative associations between anxiety and risk communication and between the appraisal of risk communication and the adoption of preventive behaviors. |
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Seroprevalence of SARS-CoV-2 IgG antibodies in two regions of Estonia
(KoroSero-EST-1) |
Jogi, Piia, Soeorg, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Seroprevalence of SARS-CoV-2 in Estonia was low even in the hotspot region. IgG concentrations were higher if fever,
difficulty breathing, shortness of breath, chest pain or diarrhea was present, or hospitalization required. A total of 3608 individual were invited and 1960 recruited From May 8 to July 31, 2020. Seroprevalence was 1.5% (95% CI 0.9-2.5) and 6.3% (95% CI 5.0-7.9),
infection fatality rate 0.1% (95% CI 0.0-0.2) and 1.3% (95% CI 0.4-2.1) in Tallinn and Saaremaa, respectively. Of seropositive subjects 19.2% (14/73) had acute respiratory illness. |
|
Jourdes, A, Lafaurie, et al |
Revue de Medecine Interne |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of our study was to describe the clinical characteristics and outcome of hospitalized patients with SARS-CoV-2
pneumonia at the Toulouse university hospital, France (March 7, 2020 to April 20, 2020). Outcomes for all 263 Covid patients were detailed |
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The Spread of COVID-19 in London: Network Effects and Optimal Lockdowns |
Julliard, Christian, Shi, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique Economics | Économie |
We find that the UK lockdown measure reduced total propagation by 57%, with more than one third of the effect coming
from the reduction in network externalities. Counterfactual analyses suggest that: i) the lockdown was somehow late, but further delay would have had more extreme consequences; ii) a targeted lockdown of a small number of highly connected geographic regions
would have been equally effective, arguably with significantly lower economic costs; iii) targeted lockdowns based on threshold number of cases are not effective, since they fail to account for network externalities. |
|
Kahamba, TrishR, Noble, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Testing found that not all swabs are created equal. However, the swabs were not tested upon patients so any conclusion
as to their relative performance in practice is doubtful. |
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TeX-Graph: Coupled tensor-matrix knowledge-graph embedding for COVID-19 drug repurposing |
Kanatsoulis, CharilaosI, Sidiropoulos, et al |
arXiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this paper we propose a novel coupled tensor-matrix framework for KG embedding. We leverage tensor factorization
tools to learn concise representations of entities and relations in knowledge bases and employ these representations to perform drug repurposing for COVID-19. Our proposed framework is principled, elegant, and achieves 100% improvement over the best baseline
in the COVID-19 drug repurposing task using a recently developed biological KG. |
|
Kane, AD, Paterson, et al |
Anaesthesia |
Healthcare Response | Réponse des soins de santé |
In this study, we establish if implementation of a bespoke peri-operative care bundle for urgent elective surgery during
a pandemic surge period can deliver a low COVID-19-associated complication profile. We present a single-centre retrospective cohort study from a tertiary care hospital of patients planned for urgent elective surgery during the initial COVID-19 surge in the
UK between 29 March and 12 June 2020. Out of 557 patients referred for surgery 535 patients (96%) had COVID-19 screening, of which 13 were positive (2.4%, 95%CI 1.4-4.1%). Out of 512 patients subsequently undergoing surgery, 7 (1.4%) developed COVID-19 positive
status (1.4%, 95%CI 0.7-2.8%) with one COVID-19-related death (0.2%, 95%CI 0.0-1.1%) within 30 days. Low rates of COVID-19 infection and mortality in the elective surgical population can be achieved within a targeted care bundle. |
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Karmaker, CL, Ahmed, et al |
Sustain Prod Consum |
Public Health response| Interventions de santé publique |
This study reveals the influential relationships and indispensable links between the drivers using fuzzy TISM to improve
the SCS in the context of COVID-19. Findings also reveal that financial support from the government as well as from the supply chain partners is required to tackle the immediate shock on SCS due to COVID-19. |
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COVID-19's Impact on the 2020-2021 Resident Match: A Survey of Otolaryngology Program Directors |
Kasle, DA, Torabi, et al |
Ann Otol Rhinol Laryngol |
Healthcare Response | Réponse des soins de santé |
The objective of this study is to determine the impact coronavirus disease of 2019 (COVID-19) will have on the 2020-2021
otolaryngology (OTO-HNS) resident application cycle. A cross-sectional survey targeting OTO-HNS program directors (PD) was created and disseminated via email to PDs on May 28th 2020. Twenty-nine of 123 solicited PDs (23.6%) completed the survey. Sixteen (55.2%)
PDs stated that virtual interviews would impact their ability to properly gauge candidates and 12 (41.4%) were unsure. Eight PDs (27.6%) stated their evaluation of candidates will likely change, with a shift toward an increased reliance on letters of recommendation,
research involvement, and clerkship grades. Virtual interviews and engagement activities will mostly supplant sub-Is and AR for the 2020-2021 OTO-HNS application cycle. |
|
Katz, M, Newmark, et al |
Contraception |
Public Health response| Interventions de santé publique |
The objective of this study is to describe the implementation and results of a proactive patient outreach project to
offer self-administered, depot medroxyprogesterone (DMPA) subcutaneous (SC) to interested patients at a California safety-net clinic following expanded state Medicaid coverage. We conducted initial outreach in May, 2020 and recorded appointment attendance
and completed injections through August, 2020. Of 90 eligible patients (age 17–54), we successfully contacted and discussed DMPA-SC with 70 (78%). Twenty-six (37%) patients expressed interest in DMPA-SC and scheduled telehealth appointments to learn to self-administer
the medication. Fifteen (58%) of those interested (21% of the total) successfully self-injected DMPA-SC. There is interest in and successful initiation of self-administered DMPA-SC among patients at an urban safety net hospital-based primary care clinic who
have used DMPA-IM in the last year. |
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Kaur, Navchetan, Oskotsky, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we developed GENEVA (GENe Expression Variance Analysis), a semi-automated framework for exploring massive
amounts of RNA-seq datasets. We applied GENEVA to 28,6650 publicly available RNA-seq samples to identify any previously studied experimental conditions that could directly or indirectly modulate ACE2 expression. We identified multiple drugs, genetic perturbations,
and diseases that modulate the expression of ACE2, including cardiomyopathy, HNF1A overexpression, and drug treatments with RAD140 and Itraconazole. Our unbiased meta-analysis of seven datasets confirms ACE2 up-regulation in all cardiomyopathy categories.
Using electronic health records data from 3936 COVID19 patients, we demonstrate that patients with pre-existing cardiomyopathy have an increased mortality risk than age-matched patients with other cardiovascular conditions. |
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Kaya, H, Çalışkan, et al |
Journal of infection in developing countries |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
The study aims to evaluate the presence of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) virus in tears
and conjunctival secretion of patients with COVID-19. A prospective interventional case series study was performed, and 32 patients with COVID-19 were selected at the Pamukkale University Hospital from 15 to 22 May 2020. By the time of the first collection
of conjunctival-tear samples, the mean time of the onset of complaints was 6.84 ± 6.81 (1-35) days. Tear-conjunctival samples from 5 patients (16%) without conjunctivitis yielded positive PCR results, 3 of whom had positive and 2 negative nasopharyngeal PCR
results. Five of 32 patients (16 %) without conjunctivitis or any eye symptoms had viral RNA in their tear-conjunctival samples. The possibility of transmission via tears and conjunctival secretions should be recognized even in the absence of conjunctivitis
or other ocular manifestations. |
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32816764; Imaging features of acute encephalopathy in patients with COVID-19: A case series |
Kihira, S, Delman, et al |
American Journal of Neuroradiology |
Clinical data| Données cliniques |
In this study we encounter MR findings of encephalopathy among 5 patients with COVID-19 during the surge of disease
in New York City from late March to late April 2020. The 5 cases presented illustrate varying imaging presentations of acute encephalopathy in patients with COVID-19. Three of 5 patients demonstrated large confluent and symmetric diffusion restriction in the
cerebral WM, with sparing of subcortical U-fibers. Given the clinically significant hypoxia encountered in patients with COVID-19, we believe that the MR findings in some cases are multifactorial, with a likely frequent component of post–hypoxic leukoencephalopathy. |
|
Viral dynamics of SARS-CoV-2 infection and the predictive value
of repeat testing |
Kissler, StephenM, Fauver, et al |
medRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
In this study we report the viral RNA trajectories for 68 individuals using quantitative PCR testing. On average, symptomatic
and asymptomatic individuals reached similar peak viral RNA concentrations (22.2 Ct, 95% credible interval [19.1, 25.1] vs. 22.4 Ct [20.2, 24.5]) within similar amounts of time (2.9 days [0.7, 4.7] vs. 3.0 days [1.3, 4.3]), but acute shedding lasted longer
for symptomatic individuals (10.5 days [6.5, 14.0] vs. 6.7 days [3.2, 9.2]). A second test within 2 days after an initial positive PCR result reliably indicated whether viral RNA concentration was increasing, decreasing, or in a low-level persistent phase.
Quantitative viral RNA assessment, informed by viral trajectory, can improve algorithms for clinical and public health management. |
|
Kitano, T, Piché-Renaud, et al |
J Pediatric Infect Dis Soc |
Public Health response| Interventions de santé publique |
Visitor restriction policies in pediatric wards during the novel coronavirus (COVID-19) outbreak are variable. Among
36 hospitals that responded to our survey, 97% allowed at least one visitor, with 67% restricting to one caregiver. 69% required the visitor to wear personal protective equipment and only 19% allowed non-household visitors. |
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Early school closures can reduce the first-wave of the COVID-19 pandemic development |
Klimek-Tulwin, M, Tulwin, et al |
Journal of Public Health (Germany) |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study aimed to assess the effect of school closures on the COVID-19 pandemic and epidemic trajectories in selected
countries. Information on the number of cases and population in each country were taken from official government reports. Dates of educational institutions closure were taken from the UNESCO database. Statistical analyses were performed using Statistica.
Most of the European countries closed schools in the period of 11–20 of March 2020. The data indicate that there was a strong correlation between the day of educational facilities closure and the incidence rate in the following days (16th, 30th, and 60th days
since the 100th confirmed case in each country). Early closure of schools in analyzed countries is statistically significantly correlated with lower incidence rates further on during the different phases of the epidemic. The available data suggest that school
closures can potentially reduce transmission during the pandemic, although more research is needed on the effectiveness of these practices. |
|
Kociolek, LK, Muller, et al |
J Clin Microbiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study assessed PCR cycle threshold (Ct) values and estimated VL in infected asymptomatic children diagnosed in
nine pediatric hospital testing programs. Records for asymptomatic and symptomatic patients with positive clinical SARS-CoV-2 tests were reviewed. The median adjusted Ct value in asymptomatic children was 10.3 cycles higher than for symptomatic children (p<
0.0001), and VL 3-4 logs lower (p<0.0001); differences were consistent (p<0.0001) across all four age brackets. Children with asymptomatic SARS-CoV-2 infection had lower levels of virus in the nasopharynx/oropharynx than symptomatic children, but timing of
infection relative to diagnosis likely impacted levels in asymptomatic children. |
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COVID-19 Self-Reported Symptom Tracking Programs in the United States: Framework Synthesis |
Koehlmoos, TP, Janvrin, et al |
J Med Internet Res |
Surveillance |
This study uses a framework synthesis to evaluate existing self-reported symptom tracking programs in the United States
for COVID-19 as an early-warning tool for probable clusters of infection. Programs were identified through keyword searches and snowball sampling, then screened for inclusion. A best fit framework was constructed for all programs that met the inclusion criteria
by collating information collected from each into a table for easy comparison. We screened 8 programs; 6 were included in our final framework synthesis. Dissimilarities included collection of data regarding smoking status, mental well-being, and suspected
exposure to COVID-19. Several programs currently exist that track COVID-19 symptoms from participants on a semiregular basis. |
|
Koya, ShaffiF, Ebrahim, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie |
This study finds a shorter time interval from onset of symptoms to death in India than that was reported in the USA
and China. Young adults without co-morbidities had shorter survival from the time of onset of symptoms irrespective of their timing of hospitalization. Hypothyroidism as a COVID-19 associated co-morbidity. As COVID-19 infection rates are accelerating rapidly
in India, it is crucial to sensitize young adults while protecting the elderly and other vulnerable populations. Case control studies are needed to further assess the thyroid-COVID-19 link. |
|
|
Kumar, A, Misra, et al |
PLoS One |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study explored the global impact of environmental temperature and neonatal Bacillus Calmette-Guérin (BCG) vaccination
coverage on transmissibility and fatality rate of COVID-19. The COVID-19 data for reported cases, deaths and global temperature were collected from 31st December 2020 to 3rd April 2020 for 67 countries. For the minimum temperature category, 28% statistically
significant lower incidence was noted for new cases from the countries falling in the second quartile (2°C to 6°C) compared with countries falling in the first quartile (-26°C to 1°C) (incidence rate ratio IRR] 0.72, 95% confidence interval CI] 0.57 to 0.93).
Countries with BCG vaccination policy had 58% less mortality as compared with countries without BCG coverage (IRR 0.42; 95% CI 0.18 to 0.95). Our exploratory study provides evidence that high temperature might not be associated with low transmissibility and
countries having neonatal BCG vaccination policy had a low fatality rate of COVID-19. |
|
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32949718; SARS-CoV-2 antibodies in healthcare workers in a large university hospital, Kerala,
India |
Kumar, A, Sathyapalan, et al |
Clinical Microbiology and Infection |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé Immunology
| Immunologie |
The ‘Kerala model’ of response to the COVID-19 pandemic was to trace, quarantine, test, isolate and treat all travellers
from foreign countries as well as neighbouring states, coupled with lockdown. This paper hypothesizes that, because of this practice, the state has succeeded in preventing community spread in the last 5 months. This is evidenced by the fact that there has
been no surge in hospital admissions due to influenza-like illness or COVID-19 clusters or outbreaks in occupational settings. Between 11th and 24th July 2020, healthcare workers in a 1200-bed university teaching hospital were recruited in this prospective,
cross-sectional, monocentric study.Serum samples from consenting HCWs were tested for SARS-CoV-2 IgG/total antibodies. Overall, 635 HCWs consented to participate in the study. Overall, the seroprevalence of SARS-CoV-2 antibody was found to be 0%. The main
limitation of our study is that it was done in a single private centre, which was a designated non-COVID-19 hospital with a manageable patient load, good infrastructure and robust infection control practices. |
|
Kurup, D, Wirblich, et al |
npj Vaccines |
Vaccine Research| Recherche sur les vaccins |
The recently emerged coronavirus SARS-CoV-2, the causative agent of COVID-19, is rapidly spreading in the world. The
exponentially expanding threat of SARS-CoV-2 to global health highlights the urgent need for a vaccine. Herein we show the rapid development of a novel, highly efficient, and safe COVID-19 vaccine using a rabies virus-based vector that has proven to be an
efficient vaccine against several emerging infectious diseases. This study reports that both a live and an inactivated rabies virus containing the SARS-CoV-2 spike S1 protein induces potent virus-neutralizing antibodies at much higher levels than seen in the
sera of convalescent patients. In summary, the results provided here warrant further development of this safe and established vaccine platform against COVID-19. © 2020, The Author(s). |
|
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Antibody kinetics and serologic profiles of SARS-CoV-2 infection using two serologic assays |
Kweon, OJ, Lim, et al |
PLoS One |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
This study aims to assess the serologic profiles and time kinetics of antibodies against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) in patients with COVID-19 using two immunoassays. A total of 97 samples serially collected from 17 patients with COVID-19 and 137 negative control samples were analyzed for IgM and IgG against SARS-CoV-2 using the AFIAS COVID-19
Ab and the EDI™ Novel Coronavirus COVID-19 ELISA Kit. With both assays, IgM and IgG rapidly increased after 7 days post symptom onset (PSO). IgM antibody levels reached a peak at 15-35 d PSO and gradually decreased. IgG levels gradually increased and remained
at similar levels after 22-35 d. Among 137 negative controls, 12 samples (8.8%) showed positive or indeterminate results. The antibody kinetics against SARS-CoV-2 are similar to common findings of acute viral infectious diseases. |
|
Lai, YH, Huang, et al |
|
Public Health response| Interventions de santé publique |
This study intends to construct a research model which based on the Technology Acceptance Model (TAM) in the context
of using the face mask ordering system to buy face masks. The research factors in the study include measurements of perceived usefulness of online face mask ordering system, perceived ease of use of online face mask ordering system, and the users' behavioral
intention to use online face mask ordering system. Responses from a total of 120 users of the face mask ordering system were collected. After all, this study has identified important factors in perceived usefulness and perceived ease of use of this mask distribution
system. |
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Larson, N, Slaughter-Acey, et al |
Public Health Nutr |
Public Health response| Interventions de santé publique |
The aim of this study is to examine how food insecurity is related to emerging adults' food behaviors and experiences
of neighborhood safety and discrimination, and identify resources needed to support their health during the COVID-19 outbreak. Participants completed the 6-item U.S. Household Food Security Survey Module, a brief measure of food insufficiency, and measures
of food behaviors, neighborhood safety, and discrimination. Open-ended questions were used to assess changes in eating behaviors during COVID-19 and needed resources. A total of 218 emerging adults (mean age=24.6±2.0 years, 70.2% female) completed a survey
in April-May 2020 during a stay-at-home order in Minnesota. The past year prevalence of food insecurity was 28.4%. Among food insecure respondents, 41.0% reported both eating less and experiencing hunger due to lack of money in the past month. Food insecure
adults reported changes including eating more food prepared at home, eating more take-out restaurant meals, and purchasing more energy-dense snacks as a result of events related to COVID-19. |
|
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Larzábal, FJ, Vilela, et al |
Medicina (Argentina) |
Clinical data| Données cliniques |
This paper present the case of a middle-aged woman with Raynaud’s syndrome who was admitted with pneumonia. During
hospitalization she was simultaneously diagnosed with infection by HIV, COVID-19 and P. jirovecci. The patient evolved favorably upon empirical treatment without requiring invasive maneuvers or ventilatory support. Outpatient follow-up after hospital discharge
was uneventful. |
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Lassen, MCH, Skaarup, et al |
ESC Heart Fail |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The present study had two aims: (i) compare echocardiographic parameters in COVID-19 patients with matched controls
and (2) assess the prognostic value of measures of left (LV) and right ventricular (RV) function in relation to COVID-19 related death. In this prospective multicentre cohort study, 214 consecutive hospitalized COVID-19 patients underwent an echocardiographic
examination (by pre-determined research protocol). All participants were successfully matched 1:1 with controls from the general population on age, sex, and hypertension. LV and RV systolic function was significantly reduced in COVID-19 cases as assessed by
global longitudinal strain (GLS) (16.4% ± 4.3 vs. 18.5% ± 3.0, P < 0.001), tricuspid annular plane systolic excursion (TAPSE) (2.0 ± 0.4 vs. 2.6 ± 0.5, P < 0.001), and RV strain (19.8 ± 5.9 vs. 24.2 ± 6.5, P = 0.004). In multivariable Cox regression reduced
TAPSE hazard ratio (HR) = 1.18, 95% confidence interval (CI) 1.07-1.31], P = 0.002, per 1 mm decrease], RV strain (HR = 1.64, 95%CI1.02;2.66], P = 0.043, per 1% decrease) and GLS (HR = 1.20, 95%CI1.07-1.35], P = 0.002, per 1% decrease) were significantly associated
with COVID-19-related death. RV and LV function are significantly impaired in hospitalized COVID-19 patients compared with matched controls. |
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33027443; Gastrointestinal emergency care during
the COVID-19 pandemic: rapid communication |
Leite, C, Trindade, et al |
Revista da Associacao Medica Brasileira (1992) |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to evaluate the frequency of consultations for severe gastrointestinal emergencies during
and before the months of the pandemic. This was a transversal study. The inclusion criteria were cases of consultation in the emergency department for gastrointestinal diseases that required hospitalization, from January to April, from 2015 to 2020. The pediatric
population (under age 12) was excluded. A total of 2,457 cases of cases was included. The number of emergency hospitalizations for gastrointestinal cases decreased during the first four months of 2020: 108, 112, 82, and 77, respectively. Comparing April of
2020 with previous years, there was a lower than expected number of cases during the social distancing period (P=0.002). This study reports a pronounced decrease in consultations for severe gastrointestinal emergencies during the pandemic. |
|
Li, Hanmo, Gu, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We propose a robust approach to estimate the heterogeneous progression of SARS-CoV-2 at all US counties having no less
than 2 COVID-19 associated deaths, and we develop the daily probability of contracting (PoC) SARS-CoV-2 for a susceptible individual to quantify the risk of SARS-CoV-2 transmission in community. We found that shortening only 5% of the infectious period of
SARS-CoV-2 can reduce around 39% (or 78K, 95% CI: 66K ,89K ]) of the COVID-19 associated deaths in the US as of 20 September 2020. Our findings also indicate that the reduction of infection and deaths by shortened infectious period is more pronounced for areas
with the effective reproduction number close to 1, suggesting that testing should be used along with other mitigation measures, such as social distancing and facial mask wearing, to reduce the transmission rate. |
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Li, L, Li, et al |
JAMA network open |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to evaluate the association between having any prior psychiatric diagnosis and COVID-19–related
mortality of hospitalized patients with COVID-19. A total of 1685 patients were hospitalized with COVID-19 during the study period (mean [SD] age, 65.2 [18.4] years; 887 [52.6%] were male). Of the 1685 patients, 473 (28%) received psychiatric diagnoses prior
to hospitalization. Patients with psychiatric diagnoses were significantly older and more likely to be female, white, and non-Hispanic and have medical comorbidities. Overall, 318 patients (18.9%) died. Patients with a psychiatric diagnosis had a higher mortality
rate compared with those with no psychiatric diagnosis. Patients with a prior psychiatric diagnosis while hospitalized for COVID-19 had a higher mortality rate compared those without a psychiatric condition. |
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Li, L, Zhang, et al |
Clin Cardiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of the study was to understand the possible risk factors that lead to death in critical inpatients with
COVID-19. In this single-center, retrospective study, we enrolled 113 critical patients with COVID-19 from Renmin Hospital of Wuhan University between February 1, 2020 and March 15, 2020. Patients who survived or died were compared. A total of 113 critical
patients with COVID-19 were recruited; 50 (44.3%) died, and 63 (55.7%) recovered. The proportion of patients with ventricular arrhythmia was higher in the death group than in the recovery group (P = .021) and was higher among patients with myocardial damage
than patients without myocardial damage (P = .013). Multivariate analysis confirmed independent predictors of mortality from COVID-19: age > 70 years (HR 1.84, 95% CI 1.03-3.28), initial neutrophil count over 6.5 × 10(9) /L (HR 3.43, 95% CI 1.84-6.40), C-reactive
protein greater than 100 mg/L (HR 1.93, 95% CI 1.04-3.59), and lactate dehydrogenase over 300 U/L (HR 2.90, 95% CI 1.26-6.67). Immunoglobulin treatment (HR 0.39, 95% CI 0.21-0.73) can reduce the risk of death. Sinus tachycardia (HR 2.94, 95% CI 1.16-7.46)
and ventricular arrhythmia (HR 2.79, 95% CI 1.11-7.04) were independent ECG risk factors for mortality from COVID-19. Old age (>70 years), neutrophilia, C-reactive protein greater than 100 mg/L and lactate dehydrogenase over 300 U/L are high-risk factors for
mortality in critical patients with COVID-19. Sinus tachycardia and ventricular arrhythmia are independent ECG risk factors for mortality from COVID-19. |
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Li, M, Gitarts, et al |
Journal of Pharmacy Practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The primary objective was to compare the incidence of thromboembolic events in adult patients with COVID-19 treated
with an unfractionated heparin (UFH) infusion versus prophylactic dose anticoagulation. Secondary objectives included exploration of the efficacy and safety of an UFH infusion through the evaluation of organ function and incidence of minor and major bleeding.
Retrospective observational cohort study with propensity score matching of COVID-19 patients who received an UFH infusion targeting an aPTT between 40 and 60 seconds. Fifty-six patients were included in this study. There was no difference in the composite
of thromboembolic events comprised of venous thromboembolism, arterial thrombosis, and catheter-related thrombosis between the UFH and control group (17.9% vs. 3.6%, P = 0.19). There was a significant increase in median D-dimer concentrations from day 1 to
day 7 in the control group (475 ng/mL 291-999] vs. 10820 ng/mL 606-21033], P = 0.04). Patients treated with UFH had a higher incidence of minor bleeding (35.7% vs. 0%, P < 0.005) and required more units of packed red blood cell transfusion (0.8 units ± 1.6
vs. 0 units, P = 0.01). Continuous infusion of UFH for patients with COVID-19 infection did not decrease the overall incidence of thromboembolic complications. UFH was associated with stabilization of D-dimer concentrations and increased rates of minor bleeding
and transfusions. |
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Li, M, Wang, et al |
Journal of infection in developing countries |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
In this study, the treatments and outcomes in 40 pediatric patients diagnosed with COVID-19 and treated with different
drugs were evaluated. All cases were diagnosed with COVID-19 nucleic acid positive by using RT-PCR or clinical manifestations, imaging specific characteristics and epidemiological clinical diagnosis. The biological information and first symptom of all cases
were collect. A variety of treatments were employed and the outcomes were evaluated by Cox regression analysis. Multivariable analysis was performed to evaluate cure rate at 14 days with different drug treatment. The average length of hospital stay was 10.4
days. The cure rate was increased with the treatment time extended and 90% of pediatric patients were cured and discharged after 14 days' treatment. And multivariable analysis results proved that none of the covariates were related to the cure rate at 14 days
with different drug treatment since p values were over 0.05. Multivariable analysis suggested that the present drug treatments cannot significantly shorten the clinical cure time and improve the cure rate of children with COVID-19. |
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Li, YutingI, Turk, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Epidemiological forecasts are beset by uncertainties in the generative model for the disease, and the surveillance
process through which data are acquired. We present a Bayesian inference methodology that quantifies these uncertainties, for epidemics that are modelled by (possibly) non-stationary, continuous-time, Markov population processes. The efficiency of the method
derives from a functional central limit theorem approximation of the likelihood, valid for large populations. We demonstrate the methodology by analysing the early stages of the COVID-19 pandemic in the UK, based on age-structured data for the number of deaths.
This includes maximum a posteriori estimates, MCMC sampling of the posterior, computation of the model evidence, and the determination of parameter sensitivities via the Fisher information matrix. Our methodology is implemented in PyRoss, an open-source platform
for analysis of epidemiological compartment models. |
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Response of an oncology unit in the midst of the COVID-19 outbreak |
Liontos, M, Kastritis, et al |
J Oncol Pharm Pract |
Healthcare Response | Réponse des soins de santé |
We report here measures taken by a major oncology Unit in Greece to continue operation of the department while ensuring
safety of the patients and health care professionals. The efficacy of these measures could serve as guidance for Oncology departments in view of a second wave of COVID-19 cases. |
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Lisker, G, Narasimhan, et al |
Home Health Care Management and Practice |
Healthcare Response | Réponse des soins de santé |
Many hospitalized patients were treated with therapies that could be administered in a home setting under proper monitoring.
We designed the CROWN Program, a Home-Care based ambulatory protocol to evaluate, monitor, and treat moderate to high risk COVID-19 patients in their homes, with escalation to hospital care when necessary. Patients were evaluated with telehealth visits with
a Pulmonologist, and a Home-Care protocol, including RN visit, pulse-oximetry, and oxygen, lab-work, intravenous fluids, medication if needed patient data, comorbidities, and symptoms were collected. Labs, including COVID-19 PCR, D Dimer, CRP, Ferritin, Procalcitonin,
CBC, and metabolic panel were measured, as were homecare, home oxygen, and intravenous fluids orders, radiographic studies and initiation of an anticoagulant. Emergency Department visits and need for hospital admission during the study period were recorded.
A total of 182 patients were enrolled between the start date of April 27th and June 1st, and fell into two categories: not-admitted (101) and post-discharge (81). Two patients were referred for hospital admission, seven were treated and released from the ED,
and one was referred to home hospice. There were no unexpected admissions or deaths. The CROWN program has demonstrated the feasibility and apparent safety of a specialized, Home-Care based protocol for the ambulatory management of moderate to high risk COVID-19
patients. |
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Liu, J, Hao, et al |
Natural Hazards |
Public Health response| Interventions de santé publique |
The purpose of this study is to uncover and optimize the structure and performance of the collaborative network that
emerged in response to COVID-19 in Hubei Province, China. This study reconstructed the Hubei Public Health Emergency Response Network as the actual collaborative network and built COVID-19 Collaborative Emergency Network as a planned task-oriented collaborative
network. Based on the data sets of the inter-organizational collaboration collected from the content analysis, this study explored the core tasks of the participating actors and their relationships during the COVID-19 emergency response, and built six sub-networks
to accomplish six core tasks. Network analysis was used with the Pajek software to compare the structural characteristics and performance of the planned network with the actual one and six sub-networks, and identified the central actors, key bridges, and brokers
in networks and sub-networks separately. Findings suggested that COVID-19 Collaborative Emergency Network had a more tightly, central, and connective structure than Hubei Public Health Emergency Response Network, because it had more participating actors (i.e.,
databases and AI systems), more powerful and strong collaborative relationships with research institutions and non-profit organizations. |
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Liu, J, Liu, et al |
Clin Respir J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of the study is to delineate clinical features of COVID-19 patients with different severities and prognoses
and clarify the risk factors for disease progression and death at an early stage. Medical history, laboratory findings, treatment, and outcome data from 214 hospitalized patients with COVID-19 pneumonia admitted to Eastern Campus of Renmin Hospital, Wuhan
University in China were collected from January 30, 2020 to February 20, 2020, and risk factors associated with clinical deterioration and death were analyzed. The final date of follow-up was March 21, 2020. Age, comorbidities, higher neutrophil cell counts,
lower lymphocyte counts and subsets, impairment of liver, renal, heart, coagulation systems, systematic inflammation and clinical scores at admission were significantly associated with disease severity. Ten (16.1%) moderate and 45 (47.9%) severe patients experienced
deterioration after admission, and median time from illness onset to clinical deterioration was 14.7 (IQR 11.3-18.5) and 14.5 days (IQR 11.8-20.0) respectively. Multivariate analysis showed increased Hazards Ratio of disease progression associated with older
age, lymphocyte count 9.5mmol/L, lactate dehydrogenase > 250 U/L and procalcitonin > 0.1 ng/mL at admission. These factors were also associated with risk of death except for BUN. Prediction models in terms of nomogram for clinical deterioration and death were
established to illustrate the probability. These findings provide insights for early detection and management of patients at risk of disease progression or even death, especially older patients and those with comorbidities. |
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Liu, Y, Liu, et al |
Chinese General Practice |
Healthcare Response | Réponse des soins de santé |
The objective was to summarize and analyze the main problems in long-term development of community public health (CPH)
teams and community-based COVID-19 containment, to develop strategies for improving long-term construction of CPH teams amid COVID-19. We collected the data during February to April 2020 by reviewing the contents of Essential Information of Community Health
Professionals in Beijing legally reported to Beijing Municipal Health Commission. We analyzed the trend of changes in the quantity, structure, post attraction and distribution inequality (using Gini coefficient) of incumbent CPH professionals during 10 consecutive
years(2010-2019) using descriptive analysis. The annual growth rate of the number of CPH professionals was 5.58% (from 2 139 in 2010 to 3 488 in 2019), which was higher than that of community staff (3.25%) and health professionals (3.26%) in the same period.
The proportion of young people(under 30 years old) decreased compared to 2010. The percentage of Beijing natives decreased from 74.10% to 70.99%. The percentage of officially budgeted decreased from 82.89% to 78.21%. Except those retired normally, a total
of 1 327 cases flowed out. Local government-led community health system can ensure a high level of equity in the distribution of CPH professionals based on population and ensure the effective implementation of epidemic containment and other community public
health services. However, there has been a gradual increase in the average age of CPH professionals, and decreased post attraction, which should be taken into consideration for further optimizing the long-term mechanism of developing the CPH team. |
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Lu, QB, Zhang, et al |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
Our objective was to estimate epidemiological parameters of COVID-19 and assess the relative infectivity of the incubation
period. The median incubation period was 7.2 (95% CI: 6.9‒7.5) days. The median serial and generation intervals were similar, 4.7 (95%CI: 4.2‒5.3) and 4.6 (95% CI: 4.2‒5.1) days, respectively. Paediatric cases < 18 years had a longer incubation period than
adult age groups (p = 0.007). The median incubation period increased from 4.4 days before 25 January to 11.5 days after 31 January (p < 0.001), whereas the median serial (generation) interval contracted from 5.9 (4.8) days before 25 January to 3.4 (3.7) days
after. The median time from symptom onset to discharge was also shortened from 18.3 before 22 January to 14.1 days after. Peak infectivity occurred 1 day before symptom onset on average, and the incubation period accounted for 70% of transmission. The high
infectivity during the incubation period led to short generation and serial intervals, necessitating aggressive control measures such as early case finding and quarantine of close contacts. |
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COVID-19 prevalence estimation: Four most affected African
countries |
Lukman, AF, Rauf, et al |
Infectious Disease Modelling |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We adopted the ARIMA model to forecast the trend of COVID-19 prevalence in the aforementioned African countries. The
datasets examined in this analysis spanned from February 21, 2020, to June 16, 2020, and was extracted from the World Health Organization website. ARIMA models with minimum Akaike information criterion correction (AICc) and statistically significant parameters
were selected as the best models. Accordingly, the ARIMA (0,2,3), ARIMA (0,1,1), ARIMA (3,1,0) and ARIMA (0,1,2) models were chosen as the best models for SA, Nigeria, and Ghana and Egypt, respectively. Forecasting was made based on the best models. It is
noteworthy to claim that the ARIMA models are appropriate for predicting the prevalence of COVID-19. We noticed a form of exponential growth in the trend of this virus in Africa in the days to come. Thus, the government and health authorities should pay attention
to the pattern of COVID-19 in Africa. Necessary plans and precautions should be put in place to curb this pandemic in Africa. |
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Macchiagodena, M, Pagliai, et al |
J Chem Theory Comput |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We implemented a combination of Hamiltonian replica exchange (HREM) and a novel nonequilibrium alchemical methodology,
called virtual double-system single-box, with increased accuracy, precision, and efficiency with respect to the standard nonequilibrium approaches. The method has been applied for the determination of absolute binding free energies of 16 newly designed noncovalent
ligands of the main protease (3CL(pro)) of SARS-CoV-2. The core structures of 3CL(pro) ligands were previously identified using a multimodal structure-based ligand design in combination with docking techniques. The calculated binding free energies for four
additional ligands with known activity (either for SARS-CoV or SARS-CoV-2 main protease) are also reported. The nature of binding in the 3CL(pro) active site and the involved residues besides the CYS-HYS catalytic dyad have been thoroughly characterized by
enhanced sampling simulations of the bound state. We have identified several noncongeneric compounds with predicted low micromolar activity for 3CL(pro) inhibition, which may constitute possible lead compounds for the development of antiviral agents in Covid-19
treatment. |
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COVID-19-Associated Systemic Thromboembolism: A Case Report and Review of the Literature |
Mahajan, P, Dass, et al |
Cardiorenal Med |
Clinical data| Données cliniques |
Elevated D-dimer levels have been observed in people with serious COVID-19 illness, and this could be helpful in guiding
treatment with anticoagulation in these patients. To analyze the role of anticoagulation as a treatment modality for COVID-19. We present the unique case of a COVID-19 patient who developed sepsis, ARDS, acute kidney injury, and deep-vein thrombosis (DVT),
who was deteriorating clinically. She was treated with anticoagulation. There was rapid recovery after treatment with systemic anticoagulation. Systemic anticoagulation could prove to be essential in the treatment of CO-VID-19. Further studies are required
to assess its role in improving long-term morbidity and mortality in these patients. |
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Malta, DC, Szwarcwald, et al |
Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil |
Public Health response| Interventions de santé publique |
To describe lifestyle changes with regard to consumption of tobacco and alcohol, food intake and physical activity,
in the period of social restriction resulting from the COVID-19 pandemic. This is a cross-sectional study conducted in Brazil with data from the ConVid online health behavior survey. The data were collected via an online questionnaire answered by the survey
participants. Post-stratification procedures were used to calculate prevalence rates and 95% confidence intervals. 45,161 individuals aged 18 years or more participated. During the period of social restriction participants reported a decrease in practicing
physical activity and an increase in time spent using computers or tablets or watching TV, intake of ultra-processed foods, number of cigarettes smoked and alcoholic beverage consumption. Differences were observed according to sex and age group. The results
indicate a worsening of lifestyles and an increase in health risk behaviors. |
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Mansoor, E, Khoudari, et al |
The American Journal of Gastroenterology |
Clinical data| Données cliniques |
This case report describes a 60-year old patient with ileocolonic Crohn's disease on azathioprine (AZA) who was diagnosed
with COVID-19 and found to have acute diarrhea leading to severe hypovolemic hyponatremia. |
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Analysis of SARS-CoV-2 ORF3a structure reveals chloride binding sites |
Marquez-Miranda, Valeria, Rojas, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We modeled the tetramer following the arrangement suggested by the low-resolution tetramer cryoEM map. Molecular dynamics
simulations of the tetramer embedded in a membrane and solvated with 0.5 M of KCl were performed. Our simulations show the cytosolic cavity is quickly populated by both K+ and Cl-, yet with different dynamics. K+ ions moved relatively free inside the cavity
without forming proper coordination sites. In contrast, Cl- ions enter the cavity, and three of them can become stably coordinated near the intracellular entrance of the potential permeation pathway by an inter-subunit network of positively charged amino acids.
Consequently, the central cavity's electrostatic potential changed from being entirely positive at the beginning of the simulation to more electronegative at the end. |
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Martin, TA, Wan, et al |
The American Journal of Gastroenterology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of the study is to characterize the risk and type of gastrointestinal bleeding (GIB) in patients with COVID-19.
This is a matched case-control (1:2) study with 41 cases of GIB (31 upper and 10 lower) in patients with COVID-19 and 82 matched controls of patients with COVID-19 without GIB. The primary objective was to characterize bleeding etiologies, and our secondary
aim was to discuss outcomes and therapeutic approaches. There was no difference in the presenting symptoms of the cases and controls, and no difference in severity of COVID-19 manifestations (P > 0.05) was observed. Ten (32%) patients with upper GIB underwent
esophagogastroduodenoscopy and 5 (50%) patients with lower GIBs underwent flexible sigmoidoscopy or colonoscopy. The most common upper and lower GIB etiologies were gastric or duodenal ulcers (80%) and rectal ulcers related to rectal tubes (60%), respectively.
Four of the esophagogastroduodenoscopies resulted in therapeutic interventions, and the 3 patients with rectal ulcers were referred to colorectal surgery for rectal packing. Successful hemostasis was achieved in all 7 cases that required interventions. Transfusion
requirements between patients who underwent endoscopic therapy and those who were conservatively managed were not significantly different. Anticoagulation and rectal tube usage trended toward being a risk factor for GIB, although it did not reach statistical
significance. In COVID-19 patients with GIB, compared with matched controls of COVID-19 patients without GIB, there seemed to be no difference in initial presenting symptoms. Of those with upper and lower GIB, the most common etiology was peptic ulcer disease
and rectal ulcers from rectal tubes, respectively. |
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Mbachu, CNP, Azubuike, et al |
Journal of infection in developing countries |
Healthcare Response | Réponse des soins de santé |
Determined the level of knowledge, attitude, practices, and impact of COVID-19 infection on healthcare workers (HCWs)
working in a South-Eastern Nigerian state. A total of 403 health care workers participated in the study. Majority of participants (88.59%) had good knowledge and good preventive practices (81.39%) of COVID-19. A significant proportion of respondents had a
poor attitude to work (25.06%) and an attitude of indifference (57.82%). Almost half (48.64%) of participants had been negatively affected by COVID-19. Knowledge significantly influenced practice. Lack of Personal protective equipment, fear of dying and going
to common places, had a significant impact on the attitude of workers. |
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Mehta, B, Jannat-Khah, et al |
RMD Open |
Healthcare Response | Réponse des soins de santé |
Examined the practice changes among rheumatologists and what they perceive the impact to be on their most vulnerable
patients. 548 rheumatologists responded from 64 countries and shared concerns of food insecurity, low health literacy, poverty and factors that preclude social distancing such as working and dense housing conditions among their patients. Although 82% of rheumatologists
had switched to telehealth video, 17% of respondents estimated that about a quarter of their patients did not have access to telehealth video, especially those from below the poverty line. The majority of respondents believed these vulnerable patients, from
racial/ethnic minorities and from low socioeconomic status groups, would do worse, in terms of morbidity and mortality, during the pandemic. |
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33031085; Nitazoxanide against COVID-19 in three explorative scenarios |
Meneses Calderón, J, Figueroa Flores, et al |
Journal of infection in developing countries |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Describe the results of treating COVID-19 positive patients with nitazoxanide in three clinical settings: pregnancy/puerperium,
hospitalized patients in an Internal Medicine Service and in an ambulatory setting. The experience with a first group of 20 women, pregnant (17) or in immediate puerperium (3) was successful in 18 cases with two unfortunate deaths. The five cases treated in
an Internal Medicine service showed a positive outcome with two patients weaned from mechanical ventilation. Of the remaining 16 patients treated in an ambulatory setting, all got cured. Nitazoxanide seems to be useful against SARS-CoV-2, not only in an early
intervention but also in critical condition as well as in pregnancy without undesired effects for the babies. As an adjunctive therapy budesonide was used that seems to contribute to the clinical improvement. |
|
Mergen, V, Kobe, et al |
European Journal of Radiology Open |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Demonstrate the first experience of a deep learning-based algorithm for automatic quantification of lung parenchymal
abnormalities in chest CT of COVID-19 patients and to correlate quantitative results with clinical and laboratory parameters. Automatic CT analysis of the lung was feasible in all patients (n = 60). The median time to accomplish automatic evaluation was 120
s. In four cases (7 %), manual corrections were necessary. Patients with need for mechanical ventilation had a significantly higher Percentage of opacity (PO, ground-glass and consolidations) (median 44 %, versus 13 %) and percentage of high opacity (PHO)
(median: 11 %, versus 3%) compared to those without. The PO and PHO moderately correlated with c-reactive protein (r = 0.49−0.60) and leucocyte count (r = 0.30−0.40). PO had a negative correlation with SO2 (r=−0.50). |
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Merino-Mateo, L, Tordable Ojeda, et al |
Actas Urologicas Espanolas |
Healthcare Response | Réponse des soins de santé |
We analyzed the impact of the COVID-19 pandemic on surgical activity in a Pediatric Urology division, as well as surgical
complications according to the Clavien-Dindo classification. Materials and methods: A systematic review of epidemiological, clinical and surgical data was carried out, including complications and readmissions of all patients operated on in the division of
Pediatric Urology within the duration of the state of alarm. Five time periods have been created according to the de-escalation phases. Results: Forty-nine surgical procedures were carried out on 45 patients (8 prior to the implementation of the de-escalation
phases). High priority pathologies were the most frequent in the first phases, being the ureteropelvic junction (UPJ) obstruction the most prevalent. Four complications were recorded (8.8%), none of them were respiratory. |
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Mikolai, J, Keenan, et al |
SSM - Population Health |
Public Health response| Interventions de santé publique |
Investigated how COVID-19-related health- and socio-economic vulnerabilities co-occur at the household level, and how
they are distributed across household types and geographical areas in the United Kingdom. Our analysis highlights four key findings. First, although COVID-19-related health risks are concentrated in retirement-age households, a substantial proportion of working-age
households also face these risks. Second, different types of households exhibit different vulnerabilities, with working-age households more likely to face financial and housing precarities, and retirement-age households health and digital vulnerabilities.
Third, there are area-level differences in the distribution of household-level vulnerabilities across England and the constituent countries of the United Kingdom. Fourth, in many households, different dimensions of vulnerabilities intersect; this is especially
prevalent among working-age households. The findings imply that the short- and long-term consequences of the COVID-19 crisis are likely to significantly vary by household type. |
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Abortion regulation in Europe in the era of COVID-19: a spectrum of policy responses |
Moreau, C, Shankar, et al |
BMJ Sex Reprod Health |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
METHODS: We collected information from 46 countries/regions: 31 for which country-experts completed a survey and 15
for which we conducted a desk review. We describe abortion regulations and changes to regulations and practice during the pandemic. RESULTS: During COVID-19, abortions were banned in six countries and suspended in one. Surgical abortion was less available
due to COVID-19 in 12 countries/regions and services were not available or delayed for women with COVID-19 symptoms in eleven. No country expanded its gestational limit for abortion. Changes during COVID-19, mostly designed to reduce in-person consultations,
occurred in 13 countries/regions. |
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Moreno-P, O, Leon-Ramirez, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Investigated whether hypokalemia acts as a biomarker of severity in coronavirus disease 2019 (COVID-19) pneumonia and
is associated with major clinical outcomes. Three hundred and six patients were enrolled. Ninety-four patients had hypokalemia and these patients showed significantly higher comorbidity (Charlson comorbidity index ≥3, 30.0% vs 16.3%) and CURB65 scores (median:
1.5 vs 1.0), as well as higher levels of some inflammatory parameters at baseline. After adjustment for confounders, hypokalemia was independently associated with requiring IMV during the admission (OR 8.98). Mortality was 15.0% and was not influenced by low
K+. Hypokalemia was associated with longer hospital and ICU stays. |
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Mort, DO, Limbu, et al |
Acute medicine |
Clinical data| Données cliniques |
COVID-19 pneumonia produces a heterogeneous array of clinical, biochemical, and radiological findings. Over the last
few months of global hurry to optimize a testing strategy, it has been suggested that bedside point-of-care lung ultrasound may have a diagnostic role. We present 3 patients with RT-PCR nasopharyngeal swab-confirmed COVID-19 pneumonia, who had an admission
plain chest film reported to be normal by a consultant radiologist, but with significant sonographic abnormalities on bedside ultrasound performed within 24 hours of the chest radiograph. Lung ultrasound may better correlate with the oxygen requirement and
overall condition of the patient than chest radiographs - a pertinent consideration given the imminent advance of the pandemic into resource-poor zones where timely access to roentgenological imaging may be sparse. |
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Mostafa, A, Kandil, et al |
Int J Epidemiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
Universal (non-symptom-based) screening of HCWs was piloted to determine the proportion of SARS-CoV-2 infection and
the associated epidemiological and clinical risk factors at a large public health care facility in Egypt. Of the 4040 HCWs screened, 170 tested positive for SARS-CoV-2 by either of the three tests (i.e. infected); 73.5% tested PCR-positive. Most infected HCWs
were nurses (57.5%). Median age of infected HCWs was 31.5 years. Of infected HCWs, 45.9% reported contact with a suspected case and 27.6% reported face-to-face contact within 2 m with a confirmed case. The proportion of infection among symptomatic HCWs was
8.8%; 11.1% had fever ≥38°C and 13.0% reported severe symptoms. Most infected HCWs were asymptomatic (68.2%). The proportion of infection among asymptomatic HCWs was 3.4%. |
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Murillo-Zamora, E, Guzmán-Esquivel, et al |
Journal of infection in developing countries |
Public health interventions*| Interventions de santé publique |
Evaluate the impact of physical distancing on the incidence of influenza as a proxy of the impact on SARS-CoV-2 contagion.
Greater decreasing trends (APCs -8.8, 95% CI: -12.5, -4.5; vs. -6.0, 95% CI: -9.9, -2.0; p = 0.026) were documented in the states with earlier school closures and across age groups, suggesting that earlier implementation of physical distance results in reduced
SARS-CoV-2 spread. |
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Murphy, Mairead, Scott, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
Investigated the rapid implementation of remote consulting and explore impact over the initial months of the COVID-19
pandemic. There was universal consensus that remote consulting was necessary. This drove a rapid change to 90% remote GP consulting (46% for nurses) by April 2020. Consultation rates reduced in April-July 2020 compared to 2019; GPs/nurses maintained a focus
on older patients, shielding patients and patients with poor mental health. Telephone consulting was sufficient for many patient problems, video consulting was used more rarely, and was less essential as lockdown eased. SMS-messaging increased more than three-fold.
GPs were concerned about increased clinical risk and some had difficulties setting thresholds for seeing patients face-to-face as lockdown eased. |
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Nabulsi, Zaid, Sellergren, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Chest radiography (CXR) is the most widely-used thoracic clinical imaging modality and is crucial for guiding the management
of cardiothoracic conditions. The detection of specific CXR findings has been the main focus of several artificial intelligence (AI) systems. However, the wide range of possible CXR abnormalities makes it impractical to build specific systems to detect every
possible condition. In this work, we developed and evaluated an AI system to classify CXRs as normal or abnormal. For development, we used a de-identified dataset of 248,445 patients from a multi-city hospital network in India. To assess generalizability,
we evaluated our system using 6 international datasets from India, China, and the United States. Of these datasets, 4 focused on diseases that the AI was not trained to detect: 2 datasets with tuberculosis and 2 datasets with coronavirus disease 2019. Our
results suggest that the AI system generalizes to new patient populations and abnormalities. In a simulated workflow where the AI system prioritized abnormal cases, the turnaround time for abnormal cases reduced by 7-28%. These results represent an important
step towards evaluating whether AI can be safely used to flag cases in a general setting where previously unseen abnormalities exist. |
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Nakanishi, H, Suzuki, et al |
The Tohoku journal of experimental medicine |
Clinical data| Données cliniques |
Coronavirus disease 2019 (COVID-19) is associated with various symptoms and changes in hematological and biochemical
variables. However, clinical features, which can differentiate COVID-19 from non-COVID-19, are not clear. We therefore examined the key clinical features of COVID-19 and non-COVID-19 patients. This study included 60 COVID-19 patients and 100 non-COVID-19 patients,
diagnosed by PCR, and no significant differences in the age and sex were seen between the two groups. The frequencies of fatigue, loose stool, diarrhea, nasal obstruction, olfactory dysfunction, taste dysfunction, underlying hyperlipidemia, and the prescription
of angiotensin II receptor blocker (ARB) were significantly higher in COVID-19 patients than those in non-COVID-19 patients. The counts of leucocytes, neutrophils, lymphocytes, eosinophils, monocytes, and basophils and the levels of chloride and calcium in
blood of COVID-19 patients were significantly lower than those of non-COVID-19 patients. The frequencies of atypical lymphocytes and the levels of lactate dehydrogenase (LDH) and potassium were significantly higher in COVID-19 than those in non-COVID-19. The
C-reactive protein (CRP) level in COVID-19 patients was significantly lower than that in non-COVID-19 patients, when we compared CRP levels among patients with elevated CRP. This study is the first to indicate that electrolyte levels and the frequency of atypical
lymphocytes in COVID-19 are significantly different from those in non-COVID-19. Fatigue, loose stool, diarrhea, nasal obstruction, olfactory dysfunction, and taste dysfunction were the key symptoms of COVID-19. Furthermore, hyperlipidemia and ARB may be risk
factors of COVID-19. In conclusion, leucocytes, leucocyte fractions, CRP, LDH, and electrolytes are useful indicators for COVID-19 diagnosis. |
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Tocilizumab and Remdesivir in a Pregnant Patient With Coronavirus Disease 2019 (COVID-19) |
Naqvi, M, Zakowski, et al |
Obstet Gynecol |
Clinical data| Données cliniques |
A 35-year-old primigravid patient at 22 weeks of gestation presented with 7 days of fever, cough, anosmia, and dyspnea.
Nasopharyngeal swab was positive for the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and a chest X-ray demonstrated bilateral patchy infiltrates. Laboratory evaluation was notable for marked elevation of interleukin-6 and
C-reactive protein concentrations. On hospital day 3, owing to increased dyspnea and oxygen requirement, the patient was treated with tocilizumab followed by 5 days of remdesivir. She responded well, recovered to room air, and was discharged home after a 9-day
hospitalization. |
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COVID-19 knowledge-based system for diagnosis in Iraq using IoT environment |
Nema, BM, Mohialden, et al |
Indonesian Journal of Electrical Engineering and Computer Science |
Healthcare Response | Réponse des soins de santé |
The importance and benefits of healthcare mobile applications is increasing rapidly, especially when such applications
are connected to the internet of things (IoT). This paper describes a smart knowledge-based system (KBS) that helps patients showing symptoms of Influenza verify being infected with Coronavirus, commonly known as COVID-19. In addition to the systems’ diagnostic
functionality, it helps these patients get medical assistance fast by notifying medical authorities using the IoT. This system displays patient’s location, phone number, date and time of examination. During the applications’ development, the developers used
Twilio, short message service (SMS), WhatsApp, and Google map applications. © 2021 Institute of Advanced Engineering and Science. All rights reserved. |
|
Nepomuceno, TCC, Silva, et al |
Journal of healthcare engineering |
Healthcare Response | Réponse des soins de santé |
Data envelopment analysis (DEA) is a powerful nonparametric engineering tool for estimating technical efficiency and
production capacity of service units. Assuming an equally proportional change in the output/input ratio, we can estimate how many additional medical resource health service units would be required if the number of hospitalizations was expected to increase
during an epidemic outbreak. This assessment proposes a two-step methodology for hospital beds vacancy and reallocation during the COVID-19 pandemic. The framework determines the production capacity of hospitals through data envelopment analysis and incorporates
the complexity of needs in two categories for the reallocation of beds throughout the medical specialties. As a result, we have a set of inefficient healthcare units presenting less complex bed slacks to be reduced, that is, to be allocated for patients presenting
with more severe conditions. The first results in this work, in collaboration with state and municipal administrations in Brazil, report 3772 beds feasible to be evacuated by 64% of the analyzed health units, of which more than 82% are moderate complexity
evacuations. The proposed assessment and methodology can provide a direction for governments and policymakers to develop strategies based on a robust quantitative production capacity measure. Copyright © 2020 Thyago C. C. Nepomuceno et al. |
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Ng, KYY, Zhou, et al |
JCO global oncology |
Healthcare Response | Réponse des soins de santé |
Evaluate the psychological effect of COVID-19 on patients with cancer, their caregivers, and health care workers and
the prevalence of burnout among HCWs. A total of 624 patients, 408 caregivers, and 421 HCWs participated in the study, with a response rate of 84%, 88%, and 92% respectively. Sixty-six percent of patients, 72.8% of caregivers, and 41.6% of HCWs reported a
high level of fear from COVID-19. The top concern of patients was the wide community spread of COVID-19. Caregivers were primarily worried about patients dying alone. HCWs were most worried about the relatively mild symptoms of COVID-19. The prevalence of
anxiety was 19.1%, 22.5%, and 14.0% for patients, caregivers, and HCWs, respectively. Patients who were nongraduates and married, and caregivers who were married were more anxious. The prevalence of burnout in HCWs was 43.5%, with more anxious and fearful
HCWs reporting higher burnout rates. |
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Low prevalence of SARS-CoV-2 in plasma of COVID-19 patients presenting to the emergency department |
Nijhuis, RHT, Russcher, et al |
Journal of Clinical Virology |
Epidemiology| Épidémiologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Correct and reliable identification of SARS-CoV-2 in COVID-19 suspected patients is essential for diagnosis. Respiratory
samples should always be tested with real-time PCR for SARS-CoV-2. In addition, blood samples have been tested, but without consistent results and therefore the added value of this sample type is unknown. The aim of this study was to determine the prevalence
of SARS-CoV-2 by real-time PCR in blood samples obtained from PCR-proven COVID-19 patients and in addition to elaborate on the potential use of blood for diagnostics. In this single center study, blood samples drawn from patients at the emergency department
with proven COVID-19 infection based on a positive SARS-CoV-2 PCR in respiratory samples were tested for the presence of SARS-CoV-2. Samples from 118 patients were selected, of which 102 could be included in the study (median age was 65 (IQR 10), 65.7 % men).
In six (5.9 %) of the tested samples, SARS-CoV-2 was identified by real-time PCR. In conclusion, SARS-CoV-2 can be detected by real-time PCR in plasma samples from patients with proven COVID-19, but only in a minority of the patients. Plasma should therefore
not be used as primary sample in an acute phase setting to identify SARS-CoV-2 infection. These findings are important to complete the knowledge on possible sample types to test to diagnose COVID-19. © 2020 Elsevier B.V. |
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Exploration of surface glycoprotein to design multi-epitope vaccine for the prevention of Covid-19 |
Oladipo, EK, Ajayi, et al |
Informatics in Medicine Unlocked |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
Stimulation and generation of T and B cell-mediated long-term immune response are essential for the curbing of a deadly
virus such as SAR-CoV-2 (Severe Acute Respiratory Corona Virus 2). Immunoinformatics approach in vaccine design takes advantage of antigenic and non-allergenic epitopes present on the spike glycoprotein of SARS-CoV-2 to elicit immune responses. T cells and
B cells epitopes were predicted, and the selected residues were subjected to allergenicity, antigenicity and toxicity screening which were linked by appropriate linkers to form a multi-epitope subunit vaccine. The physiochemical properties of the vaccine construct
were analyzed, and the molecular weight, molecular formula, theoretical isoelectric point value, half-life, solubility score, instability index, aliphatic index and GRAVY were predicted. The vaccine structure was constructed, refined, validated, and disulfide
engineered to get the best model. Molecular binding simulation and molecular dynamics simulation were carried out to predict the stability and binding affinity of the vaccine construct with TLRs. Codon acclimatization and in silico cloning were performed to
confirm the vaccine expression and potency. Results obtained indicated that this novel vaccine candidate is non-toxic, capable of initiating the immunogenic response and will not induce an allergic reaction. The highest binding energy was observed in TLR4
(Toll-like Receptor 4) (−1398.1), and the least is TLR 2 (−1479.6). The steady rise in Th (T-helper) cell population with memory development was noticed, and IFN-g (Interferon gamma) was provoked after simulation. At this point, the vaccine candidate awaits
animal trial to validate its efficacy and safety for use in the prevention of the novel COVID-19 (Coronavirus Disease 2019) infections. © 2020 The Author(s) |
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Social inequalities in the progression of COVID-19 in the Mexican population |
Ortiz-Hernández, L, Pérez-Sastré, et al |
Revista Panamericana de Salud Publica/Pan American Journal of Public Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To determine if there are disparities associated with socioeconomic stratification, ethnicity, medical services, and
geographic region in the progression of coronavirus disease (COVID-19) in Mexican adults infected with SARS-CoV-2. We analyzed data registered by the General Direction of Epidemiology of the Ministry of Health of the Federal Government of Mexico regarding
the confirmed cases of SARS-CoV-2 infection. The analysis was limited to data from adults 20 years and older recorded up to July 10, 2020 (n=234 870). People who lived in municipalities with greater marginalization were at greater risk of presenting the four
indicators of severe forms of COVID-19 (PR=1.05 or 1.06). Indigenous people were at greater risk of pneumonia (PR=1.22), hospitalization (PR=1.14) and death (PR=1.23). Among the cases treated in the private health sector, the risk of death was lower (PR=0.40),
but the use of intubation or admission to the intensive care unit was higher (PR=4.45). The trends observed indicate that the effects of COVID-19 are not only related to the biological characteristics of SARS-CoV-2, but also to the resources (or lack thereof)
to deal with it, which are distributed by social processes. |
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Pandey, D, Bansal, et al |
PLoS One |
Public Health response| Interventions de santé publique |
The aim of this study is to explore the degree of psychological distress in terms of-Depression, Anxiety and Stress
among the adult population in India during the strict 21 days mandatory lockdown. A cross sectional survey design was adopted to assess the psychological state of general population in India, during the COVID-19 mandatory lockdown period, with the help of
a validated questionnaire. The reported prevalence of depression was around 30.5%, which was the highest among the variables of psychological health. Anxiety was reported by 22.4%, followed by stress which was seen in 10.8% of respondents. In the third week
the incidence of depression (37.8% versus 23.4%; p<0.001), anxiety (26.6% versus 18.2%; p<0.001) and stress (12.2% versus 9.3%; p<0.045) was reported to be significantly higher as compared to second week. Our results suggest a progressively detrimental impact
of lockdown on various aspects of psychological health. |
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Papa, A, Gasbarrini, et al |
The American Journal of Gastroenterology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We reviewed data on the prevalence and clinical outcomes of COVID-19 in patients with inflammatory bowel disease (IBD).
COVID-19 prevalence in patients with IBD was comparable with that in the general population. Therapies using antitumor necrosis factor-α agents have been associated with better clinical outcomes. Management and treatments provided by gastroenterologists were
effective in reducing COVID-19 risk. Antitumor necrosis factor-α agents seem to mitigate the course of COVID-19. |
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Park, Hyung Jun, Chae, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique
Public Health response| Interventions de santé publique |
We conducted time-series cross-sectional regressions with lagged dependent variables, regional fixed effects, regional
time-trends, and cluster-robust standard errors using England’s data on confirmed COVID-19 cases from 1 March to 30 June. We examined the effects of government disapproval on the time-dependent reproduction number, Rt. Disapproval was interacted with a lockdown
dummy to assess whether citizens’ support for the government still affected the Rt under harsh interventions like lockdowns. As sensitivity tests, we used different lags (four, five, six, and seven days) on the main variables, ran the analysis without the
interaction term, and used an alternative dependent variable. A percent point increase in disapproval resulted in a 0·012 (95% CI 0·005 to 0·019; P=0·014) increase in the time-dependent reproduction number (Rt). Under lockdown, a percent point rise in disapproval
increased the Rt by 0·008. : Non-pharmaceutical interventions are more effective when governments are popular. Because governments both design and execute these interventions, people are less likely to abide by the restrictions designed by the government when
they do not believe the government is doing a good job. |
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Prediction of the infection of COVID-19 in Bangladesh by classical
SIR model |
Parvez, Sofi Mahmud, Tabassum, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The first patient of COVID-19 was officially reported on March 8, 2020, in Bangladesh. Using the epidemiological data
up to October 17, 2020, we try to estimate the infectious size. In this paper, we used Classical SIR (Susceptible- Infected-Recovered), model. The necessary reproduction number Ro of Bangladesh is 1.92. The primary data was collected from the COVID-19 Dashboard.
In our analysis, the statistical parameters specify the best import to provide the predicted result. We projected that the epidemic curve pulling down in Bangladesh will start from the first week of November (November 4, 2020) and may end in the last week
of July (July 24, 2021). It is also estimated that the start of acceleration on May 24, 2020, in 53 days, and the start of steady growth on September 10, 2020, in 109 days. The start of the ending phase of the epidemic may appear in the first week of November
2020, and the epidemic is expected to be finished by the last week of July 2021. However, these approximations may become invalid if a large variety of data occurs in upcoming days. |
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Paul, Elise, Steptoe, et al |
medRxiv |
Public Health response| Interventions de santé publique |
We estimate predictors of four domains of negative attitudes towards vaccines and identify groups most at risk of uncertainty
and unwillingness to receive a COVID-19 vaccine in a large sample of UK adults. Data were from 32,361 adults in the UCL COVID-19 Social Study. 16% of respondents displayed high levels of mistrust or misinformation about vaccines across one or more domains.
Distrustful attitudes towards vaccination were higher amongst individuals from ethnic minority backgrounds, with lower levels of education, lower annual income, poor knowledge of COVID-19, and poor compliance with government COVID-19 guidelines. Overall, 14%
of respondents reported unwillingness to receive a vaccine for COVID-19, whilst 22% were unsure. The largest predictors of both COVID-19 vaccine uncertainty and refusal were low income (< 30,000 GBP a year), having not received a flu vaccine last year, poor
adherence to COVID-19 government guidelines, female gender, and living with children. Amongst vaccine attitudes, intermediate to high levels of vaccine benefit mistrust and concerns about future unforeseen side effects were the most important determinants
of both uncertainty and unwillingness to vaccinate against COVID-19. Negative attitudes towards vaccines are major public health concerns in the UK. |
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Pellegrini, José Augusto Santos, Rech, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to investigate the incidence of VTE among mechanically ventilated adults with COVID-19 pneumonia,
relative to among patients with respiratory failure related to other causes. Between June 2, 2020 and August 11, 2020, this prospective study enrolled critically ill adults with suspected COVID-19 pneumonia who required mechanical ventilation within 24 h after
hospital admission. The patients were followed until death or hospital discharge. Sequential ultrasonography screening of the lower extremities and catheter insertion sites, as well as testing for plasma biochemical markers, were performed at the intensive
care unit admission, day 3, day 7, and day 14. The primary outcome was a composite of deep venous thrombosis, pulmonary embolism, and thrombosis at the central catheter insertion sites. We enrolled 70 patients, including 57 patients with COVID-19 and 13 patients
without COVID-19, and all patients completed follow-up. The incidence of the primary outcome was higher among patients with COVID-19 than among patients with respiratory failure related to other etiologies (36·8% vs. 0%, p=0·023). Multivariate regression analysis
revealed that VTE was independently associated with a COVID-19 diagnosis (odds ratio: 6·28, 95% confidence interval: 1·19–68·07) and D-dimer concentration (1-ng/mL increase, odds ratio: 1·15, 95% confidence interval: 1·05–1·30). |
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Pellicciaro, M, Granai, et al |
International Journal of Surgery Case Reports |
Clinical data| Données cliniques |
We reported a case of a 53-years-old women with early breast cancer and simultaneous asymptomatic SARS-CoV-2 infection.
According to COVID-19 breast cancer recommendations she underwent hormone neoadjuvant treatment as a bridging therapy for surgery. Six months from the diagnosis, after virus eradication, patient underwent breast surgery. No SARS-CoV-2 RNA was found both in
the surgical specimen and sentinel lymph node but micrometastasis were reported. During the last follow-up, the patient was in good clinical condition and started the adjuvant chemotherapy. Upfront awake surgery should be preferred especially in asymptomatic
COVID-19 patient with early breast cancer when monitoring of tumor response is not feasible. |
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Peña, VH, Espinosa, et al |
Medwave |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Healthcare
Response | Réponse des soins de santé |
This study proposes a methodology to estimate the saturation moment of hospital intensive care beds and determine the
number of units required to compensate for this saturation. A total of 22,016 patients with diagnostic confirmation for COVID-19 caused by SARS-CoV-2 were analyzed between March 4 and May 5, 2020, nationwide. Based on information from the Chilean Ministry
of Health and ministerial announcements in the media, the overall availability of critical care beds was estimated at 1,900 to 2,000. The Gompertz function was used to estimate the expected number of COVID-19 patients and to assess their exposure to the available
supply of intensive care beds in various possible scenarios, taking into account the supply of total critical care beds, the average occupational index, and the demand for COVID-19 patients who would require an intensive care bed. A 100% occupancy of critical
care beds could be reached between May 11 and May 27. This condition could be extended for around 48 days, depending on how the expected over-demand is managed. A simple, easily interpretable, and applicable to all levels (nationwide, regionwide, municipalities,
and hospitals) model is offered as a contribution to managing the expected demand for the coming weeks and helping reduce the adverse effects of the COVID-19 pandemic. |
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Perone, Gaetano |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this article, I analysed several time series forecasting methods to predict the spread of COVID-19 second wave in
Italy, over the period after October 13, 2020. I used an autoregressive model (ARIMA), an exponential smoothing state space model (ETS), a neural network autoregression model (NNAR), and the following hybrid combinations of them: ARIMA-ETS, ARIMA-NNAR, ETS-NNAR,
and ARIMA-ETS-NNAR. About the data, I forecasted the number of patients hospitalized with mild symptoms, and in intensive care units (ICU). The data refer to the period February 21, 2020-October 13, 2020 and are extracted from the website of the Italian Ministry
of Health (this http URL). The results show that i) the hybrid models, except for ARIMA-ETS, are better at capturing the linear and non-linear epidemic patterns, by outperforming the respective single models; and ii) the number of COVID-19-related hospitalized
with mild symptoms and in ICU will rapidly increase in the next weeks, by reaching the peak in about 50-60 days, i.e. in mid-December 2020, at least. To tackle the upcoming COVID-19 second wave, on one hand, it is necessary to hire healthcare workers and implement
sufficient hospital facilities, protective equipment, and ordinary and intensive care beds; and on the other hand, it may be useful to enhance social distancing by improving public transport and adopting the double-shifts schooling system. |
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Haemoptysis as the first presentation of COVID-19: a case report |
Peys, E, Stevens, et al |
BMC Pulm Med |
Clinical data| Données cliniques |
Case Report: A 58-year-old man presented at the emergency department with acute onset haemoptysis. On the fifth day
after admission, he developed massive haemoptysis. Computed tomography (CT) angiography of the chest revealed alveolar haemorrhage, more prominent in the left lung. Flexible bronchoscopy confirmed bleeding from the left upper lobe, confirmed by a bronchial
arteriography, which was successfully embolized. Nasopharyngeal swabs (NPS) tested for SARS-CoV-2 using real-time polymerase chain reaction (RT-PCR) repeatedly returned negative. Surprisingly, SARS-CoV-2 was eventually detected in bronchoalveolar lavage (BAL)
fluid. |
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Picone, M, Inoue, et al |
Population Health Management |
Public Health response| Interventions de santé publique |
In a pilot study, the authors used social listening to quickly extract information from social media channels to explore
what people with COVID-19 are talking about regarding symptoms and disease progression. The goal was to determine whether, by amplifying patient voices, new information could be identified that might have been missed through other sources. Two data sets from
social media groups of people with or presumed to have COVID-19 were analyzed: a Facebook group poll, and conversation data from a Reddit group including detailed disease natural history-like posts. Content analysis and a customized analytics engine that incorporates
machine learning and natural language processing were used to quickly identify symptoms mentioned. Key findings include more than 20 symptoms in the data sets that were not listed in online lists of symptoms from 4 respected medical information sources. The
disease natural history-like posts revealed that people can experience symptoms for many weeks and that some symptoms change over time. This study demonstrates that social media can offer novel insights into patient experiences as a source of real-world data.
This inductive research approach can quickly generate descriptive information that can be used to develop hypotheses and new research questions. |
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Pierce, Andrew, Haworth-Brockman, et al |
Research Square prepub |
Public health interventions*| Interventions de santé publique |
We conducted an ecological study using data from Canada’s national influenza surveillance system to investigate whether
social distancing measures to control COVID-19 reduced the incidence of seasonal influenza. Data taken from three separate time frames facilitated analysis of the 2019-20 influenza season prior to, during, and following the implementation of COVID-19 related
measures and enabled comparisons to the same time periods during three preceding flu seasons. The incidence of specific influenza strains was of primary focus. Further analysis was performed to determine the number of new laboratory-confirmed influenza or
influenza like illness outbreaks. Our results indicate a premature end to the 2019-20 influenza season, with a significantly fewer number of cases and outbreaks being recorded following the enactment of many COVID-19 social distancing polices. The incidence
of influenza strains A (H3N2), A (unsubtyped), and B were all significantly lower at the tail-end of the 2019-20 influenza season, compared with preceding seasons. |
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32980842; Management of COVID-19 Coagulopathy in a Patient with Severe Haemophilia A |
Pinto Pereira, J, Hantson, et al |
Acta Haematologica |
Clinical data| Données cliniques |
A 54-year-old man with a long history of severe haemophilia A treated prophylactically with efmoroctocog alpha (3,000
IU twice weekly) was diagnosed with COVID-19 infection. He had multiple risk factors for COVID-19 severity including obesity, diabetes mellitus and hypertension. He required prolonged intensive care unit (ICU) stay due to the severity of respiratory failure
until his death on day 24. During his ICU stay, he received a continuous infusion of efmoroctocog alpha in order to maintain factor VIII activity between 80 and 100%, together with therapeutic doses of low-molecular-weight heparin targeting anti-Xa activity
above 0.5 IU/mol. He tolerated numerous invasive procedures without bleeding. At post-mortem examination, there was no evidence for thrombosis or haemorrhage in the different organs. © 2020 |
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Pohl, MarieO, Busnadiego, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, we characterized 14 different low-passage replication-competent human SARS-CoV-2 isolates representing all the
major European clades observed during the first pandemic wave in early 2020. By integrating viral sequencing data from patient material, viral stocks and passaging experiments, with kinetic virus replication data from non-human Vero-CCL81 cells and primary
differentiated human bronchial epithelial cells (BEpCs), we observed several SARS-CoV-2 sequence features that associate with distinct phenotypes. Notably, naturally-occurring substitutions in Orf3a (Q57H) and nsp2 (T85I) were associated with poor replication
in Vero-CCL81 cells but not in BEpCs, while SARS-CoV-2 isolates expressing the Spike D614G substitution generally exhibited enhanced replication abilities in BEpCs. Strikingly, low-passage Vero-derived stock preparation of 3 SARS-CoV-2 isolates selected for
substitutions at positions 5/6 of E, and were highly attenuated in BEpCs, revealing a key cell-specific function to this region. Rare isolate-specific deletions were also observed in the Spike furin-cleavage site during Vero-CCL81 passage, but these were rapidly
selected against in BEpCs, underscoring the importance of this site for SARS-CoV-2 replication in primary human respiratory cells. Overall, our study uncovers natural sequence features in the SARS-CoV-2 genome that determine efficient virus replication and
tropism for the human respiratory epithelium. |
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Physical distancing in schools for SARS-CoV-2 and the resurgence of rhinovirus |
Poole, Stephen, Brendish, et al |
The Lancet Respiratory Medicine |
Public health interventions*| Interventions de santé publique |
In Southampton, UK, we tested adult medical patients admitted to hospital using point-of-care multiplexed PCR testing
for a wide range of respiratory viruses, including SARS-CoV-2, from the height of the pandemic. We compared the rate of respiratory virus detection in 2020 with the same period in 2019. 3898 adult patients were tested between March 23 and Sept 20, 2020, and
1898 adults during the same period in 2019. There was a drop in the rate of detection of all respiratory viruses including rhinovirus following the nationwide lockdown on March 23, 2020. Detection of rhinovirus remained low after the easing of national lockdown
on the May 10, 2020, compared with the previous year. Around 2 weeks after the concurrent re-opening of state primary and secondary schools in early September, there was a sharp increase in the number of detections similar to that seen in 2019. Our data support
previous reports that children are a major reservoir for rhinovirus infection, and a key driver of transmission to adults. Furthermore, our data suggests that current physical distancing measures adopted by schools do not effectively prevent rhinovirus transmission.
These findings might have important implications for circulation of both influenza and SARS-CoV-2 in the coming winter months. |
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Intersectional Disparities Among Hispanic Groups in COVID-19 Outcomes |
Poulson, M, Neufeld, et al |
J Immigr Minor Health |
Epidemiology| Épidémiologie |
Using data from the Centers for Disease Control and Prevention, we performed multivariate Poisson regression assessing
risk of hospitalization and death in Hispanic White (HW), Hispanic Black (HB), and Hispanic Multiracial/Other (HM) groups compared to non-Hispanic Whites (NHW). The relative risk of hospitalization was 1.35, 1.58, and 1.50 (p < 0.001) for HW, HB, and HM individuals
respectively when compared to NHW. Relative risk of death was 1.36, 1.72, 1.68 (p < 0.001) times higher in HW, HB, and HM compared to NHW. HW, HB, and HM individuals also had significantly increased risk of requiring mechanical ventilation and ICU admission
when compared to NHW. |
|
Prentiss, MaraG, Chu, et al |
medRxiv |
Transmission |
We study transmission of COVID-19 using five well-documented case studies : a Washington state church choir, a Korean
call center, a Korean exercise class, and two different Chinese bus trips. In all cases the likely index patients were pre-symptomatic or mildly symptomatic. An estimate of N 0 , the characteristic number of COVID-19 virions needed to induce infection in each
case, is found using a simple physical model of airborne transmission. We find that the N 0 values are similar for five COVID-19 superspreading cases (~300-2,000 viral copies) and of the same order as influenza A. Consistent with the recent results of Goyal
et al , these results suggest that viral loads relevant to infection from presymptomatic or mildly symptomatic individuals may fall into a narrow range, and that exceptionally high viral loads are not required to induce a superspreading event. Rather, the
accumulation of infective aerosols exhaled by a typical pre-symptomatic or mildly symptomatic patient in a confined, crowded space (amplified by poor ventilation, particularly activity like exercise or singing, or lack of masks) for exposure times as short
as one hour are sufficient. We calculate that talking and breathing release ~460 N 0 and ~10 N 0 (quanta)/hour, respectively, providing a basis to estimate the risks of everyday activities. Finally, we provide a calculation which motivates the observation
that fomites appear to account for a small percentage of total COVID-19 infection events. |
|
|
Punjani, N, Ha, et al |
Journal of drugs in dermatology : JDD |
Epidemiology| Épidémiologie |
Outcomes from 911,310 individuals tested for COVID-19 in metropolitan NYC between Feb. 29 - June 12., 2020 were evaluated
for sex disparity. 434,273 (47.65%) were male and 477,037 (52.35%) were female. Men represented the majority of positive cases (n=106,275, 51.36%), a majority of hospitalizations (n=29,847, 56.44%), and a majority of deaths (n=13,054, 59.23%). Following population
level adjustments for age and sex, testing rates of men and women were equivalent. The majority of positive cases and hospitalizations occurred in men for all age groups except age >75 years, and death was more likely in men of all age groups. Men were at
a statistically significant greater relative risk of case positivity, hospitalization, and death across all age groups except those <18 years of age. |
|
|
Qasim, Z, Sjoholm, et al |
Journal of Trauma and Acute Care Surgery |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
For this report, we examined the volume, acuity, and mechanisms of presenting trauma patients and the number and acuity
of COVID-19 admissions at Level 1 trauma centers in Philadelphia during the pandemic. We also assessed the geospatial relationship between firearm incidents and COVID-19 case density. Over the first 6 weeks of the pandemic, trauma contacts totaled 1,058 patients
across all centers representing a 20% decrease compared with the same time last year. However, the number of penetrating trauma cases increased with a significant correlation between shooting locations and high-density COVID areas. During this time, Philadelphia
trauma centers admitted a total of 1,413 confirmed COVID-19 patients, and 23% required mechanical ventilation. Divert status was activated for only 1.6% of available hours, and five of six centers remained open to all trauma transfers over the entire study
period. Thus, through deliberate efforts to adapt ACS-COT guidelines and share lessons learned, the Level I trauma centers in Philadelphia maintained trauma access while simultaneously responding to the high-acuity infectious pandemic. |
|
|
Comparative Effectiveness of Lopinavir/Ritonavir-Based Regimens in COVID-19 |
Qu, J, Li, et al |
Clin Exp Pharmacol Physiol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Here we evaluated the efficacy of the Lopinavir/Ritonavir (LPV/r) and its combination with other drugs in the treatment
of COVID-19. We included 170 confirmed COVID-19 patients who had been cured and discharged. Their antiviral therapies were LPV/r alone or combinations with Interferon (IFN), Novaferon and Arbidol. We evaluated the medications efficacy by comparing the time
of the negative nucleic acid conversion and the length of hospitalization mainly. The LPV/r+Novaferon 6.00(4.00-8.00) &7.50(5.00-10.00) days] had shorter time of the negative nucleic acid conversion (P=0.0036) and shorter time of hospitalization(P<0.001) compared
with LPV/r alone 9.00(5.00-12.00) &12.00(11.00-15.00) days] and LPV/r+ IFN 9.00(7.25-11.00) &12.00(10.00-13.50) days]. On the contrary, LPV/r+IFN 9.00(7.25-11.00) & 12.00(10.00-13.50) days] had shorter time of the negative nucleic acid conversion (P=0.031)
and shorter time of hospitalization (P<0.001) compared with LPV/r+IFN+Novaferon 10.00(8.00-11.25) & 13.50(11.50-17.00) days] and LPV/r+IFN+Arbidol 14.00(9.75-19.00) & 19.50(13.25-24.00) days]. In conclusion, the combination of LPV/r and Novaferon may have
better efficacy against COVID-19. However, adding IFN based on LPV/r+Novaferon or adding Arbidol based on LPV/r+IFN may not improve the efficacy. |
|
Qu, Yuanke, Cheung, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We would like to present an agent-based model (ABM-HK) to predict the effectiveness of the upcoming Hong Kong population
SARS-CoV-2 screening in early September. We realize that to ensure safety of school reopening on September 23rd, the universal community testing programme needs to have a participation rate of at least 70%. However, a 50% participated programme can be matched
by a partial compulsory follow-up programme targeting high groups to ensure safety of school reopening. Finally, ABM-HK expects a rise in the daily confirmed cases toward the end of the year regardless of the participation rate of the upcoming programme. Therefore,
active testing programmes targeting students and other young cohorts should be seriously considered and implemented by latest November. |
|
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Trends in suicide rates during the COVID-19 pandemic restrictions
in a major German city |
Radeloff, Daniel, Papsdorf, et al |
medRxiv |
Public Health response| Interventions de santé publique |
In this study, we compared data on suicide events in a major city in Germany before and during periods of 2020 with
social restrictions. To avoid distortions due to seasonal fluctuations in suicide risk, data from 2020 were compared to data from 2010 to 2019. A total of 333 suicides were registered and 2,791,131 life years (LY) were spent between 2010 and 2020. Of these,
42 suicides and 300,834 LY accounted for the year 2020. In 2020, suicide rates (SR, suicides per 100,000 LY) were lower in periods with moderate (SR = 8.5, X^2 = 4.374, p = 0.037) or severe COVID-19 restrictions (SR = 7.0, X^2 = 3.999, p = 0.046) compared
with periods without restrictions (SR = 18.0). A comparison with preceding years showed that differences cannot be attributed to seasonal variations. No age- or gender differences were found. |
|
Ramírez-Correa, P, Ramírez-Rivas, et al |
Symmetry |
Public Health response| Interventions de santé publique |
The objective of this study is to determine which model, the Theory of Planned Behavior or the Technology Acceptance
Model, provides greater explanatory power for the adoption of telemedicine addressing outlier-associated bias. We carried out an online survey of patients. The data obtained through the survey were analyzed using both consistent partial least squares path
modeling (PLSc) and robust PLSc. The latter used a robust estimator designed for elliptically symmetric unimodal distribution. Both estimation techniques led to similar results, without inconsistencies in interpretation. In short, the results indicate that
the Theory of Planned Behavior Model provides a significant explanatory power. Furthermore, the findings show that attitude has the most substantial direct effect on behavioral intention to use telemedicine systems. |
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|
Rani, Geeta, Oza, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Coronavirology| Coronavirologie |
The objective of this research is to design and develop a deep learning model for finding the degree of similarity
of the genome of the Severe Acute Respiratory Syndrome-Coronavirus 2 (‘SARS-CoV-2’) with a given genome. This research also aims at detecting the genome of ‘SARS-CoV-2’ in the host human beings. The experimental results on the dataset publicly available at
National Centre for Biotechnology Information, show that the model is effective in predicting the similarity score of the genomic sequence of ‘SARS-CoV-2’ and other prevalent viruses such as Severe Acute Respiratory Syndrome-Coronavirus, Middle East Respiratory
Syndrome Coronavirus, Human Immunodeficiency Virus, and Human T- cell Leukaemia Virus. This is successful in detecting the genome of ‘SARS-CoV-2’ in the host genome with an accuracy of 99.27%. It may prove a useful tool for doctors to quickly classify the
infected and non-infected genomes. It can also be useful in finding the most effective drug from the available drugs for the treatment of ‘COVID-19’. |
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Early use of nitazoxanide in mild Covid-19 disease: randomized,
placebo-controlled trial |
Rocco, Patricia Rieken Macedo, Silva, et al |
medRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
This multicenter, randomized, double-blind, placebo-controlled trial, investigated therapeutic effect of the antiparasitic
drug nitazoxanide on SARS-CoV-2 infection. |
|
Reaction to a Pandemic: Social Distancing and Driving Among Older Adults During COVID-19 |
Roe, CM, Rosnick, et al |
Journal of Applied Gerontology |
Public Health response| Interventions de santé publique |
A cohort study of driving behavior from January 1, 2019, to April 25, 2019, and January 1, 2020, to April 25, 2020,
was conducted to determine if older adults would modify their movements after COVID-19 case acceleration. Data from 214 adults aged 66.5 to 92.8 years were used. Women comprised 47.6% of the sample and 15.4% were African American. Participants reduced the
proportion of days driven during the pandemic (.673 vs.382 p <.001]) compared with same period the year before (.695 vs.749). Trips/day showed a similar decline (p <.001). Participants also took shorter trips (p =.02), drove slower (p <.001), had fewer speeding
incidents (p <.001), and had different trip destinations (p <.001). These results indicate that older adults reduce their driving behavior when faced with a pandemic. |
|
Rogers, NT, Waterlow, et al |
Frontiers in Public Health |
Public Health response| Interventions de santé publique |
We assessed whether lockdown had a disproportionate impact on physical activity behavior in groups who were, or who
perceived themselves to be, at heightened risk from COVID-19. Physical activity intensity (none, mild, moderate, or vigorous) before and during the UK COVID-19 lockdown was self-reported by 9,190 adults between 2020-04-06 and 2020-04-22. Most (63.9%) participants
maintained their normal physical activity intensity during lockdown, 25.0% changed toward less intensive activity and 11.1% were doing more. |
|
|
Rojas-Ocaña, MJ, Araujo-Hernández, et al |
Sustainability (Switzerland) |
Healthcare Response | Réponse des soins de santé |
The objective of the present study was to describe the perceptions and lived experiences of primary care nurses in
Spain during the COVID-19 health emergency. A qualitative study taking a phenomenological approach was carried out, triangulating data collected through non-participant observations, eight in-depth interviews, and two discussion groups with community nurses
and case managers. A total sample of 20 key informants was obtained during the month of May, 2020. The key informants expressed strong positive perceptions of the recognition received from service users and satisfaction when acknowledging that they have been
an important source of emotional support. Informants identify the importance of their work in sustaining the system, particularly outlining team cohesion and communication, whilst also evaluating the empowering position in which service users and society itself
has put them. |
|
|
Rosenke, K, Jarvis, et al |
JCI Insight |
Therapeutics| Thérapeutique Animal model | Modèle animal |
Here we assessed the prophylactic/therapeutic efficacy of hydroxychloroquine (HCQ), a drug of interest for COVID-19
management, in two animal disease models. The standard human malaria HCQ prophylaxis (6.5 mg/kg given weekly) and treatment (6.5 mg/kg) did not significantly benefit clinical outcome nor reduce SARS-CoV-2 replication/shedding in the upper and lower respiratory
tract in the rhesus macaque disease model. Similarly, when used for prophylaxis or treatment neither the standard human malaria dose (6.5 mg/kg) nor a high dose (50 mg/kg) of HCQ had any beneficial effect on clinical disease or SARS-CoV-2 kinetics (replication/shedding)
in the Syrian hamster disease model. Results from these two preclinical animal models may prove helpful in guiding clinical use of HCQ for prophylaxis/treatment of COVID-19. |
|
|
Rossen, LM, Branum, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie |
As of October 15, 216,025 deaths from COVID-19 have been reported in the United States; however, this might underestimate
the total impact of the pandemic on mortality. Overall, an estimated 299,028 excess deaths occurred from late January through October 3, 2020, with 198,081 (66%) excess deaths attributed to COVID-19. The largest percentage increases were seen among adults
aged 25–44 years and among Hispanic or Latino persons. These results inform efforts to prevent mortality directly or indirectly associated with the COVID-19 pandemic, such as efforts to minimize disruptions to health care. |
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|
Rothgang, H, Domhoff, et al |
Pflege |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
Article in German. The study aims to describe the extent to which nursing homes are affected, the human and material
resources of nursing homes, the organizational handling of the situation, and their requests for public support. More than 7,000 nursing homes were invited to participate in an online survey with quantitative and qualitative elements. Data analysis applies
descriptive statistics. 824 nursing homes participated in the survey. One in five nursing homes has at least one confirmed case of SARS-CoV-2 among its residents and / or employees. As about half of all deceased people with COVID-19 have been living in nursing
homes, the support of nursing homes in their attempt to restrict the pandemic requires highest attention. |
|
|
Rozaliyani, A, Savitri, et al |
Acta medica Indonesiana |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This is an analysis using data from the ongoing recapitulation of Epidemiological Surveillance (ES) by the Provincial
Health Office of Jakarta from March 2nd to April 27th 2020. We evaluated demographic and clinical characteristics of all confirmed cases in association with death. of the 4,052 patients, 381 (9.4%) patients were deceased. Multivariable analysis showed that
death was associated with older age (odds ratio OR] 1.03; 95% confidence interval CI] 1.02, 1.05, per year increase; p<0.001), dyspnea (OR 4.83; 95% CI 3.20, 7.29; p<0.001), pneumonia (OR 2.46; 95%CI 1.56, 3.88; p<0.001), and pre-existing hypertension (OR
1.86; 95% CI 1.24, 2.78; p=0.003). Death was highest in the week of April 6th 2020 and declined in the subsequent weeks, after a large-scale social restriction commenced. |
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|
Rumain, BarbaraT, Schneiderman, et al |
medRxiv |
Epidemiology| Épidémiologie |
A number of studies have reported that adolescents are significantly less susceptible than older adults. We examined
data from six U.S. states experiencing surges in the number of cases to determine prevalence of COVID-19, and two other measures, related to prevalence in adolescents and youth as compared to older adults. Prevalence of COVID-19 for adolescents and for youth
was significantly greater than for older adults (p<.00001), as was percentage observed ÷ percentage expected (p<.005). results are contrary to previous findings that adolescents are less susceptible than older adults. |
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|
Russo, V, Cardillo, et al |
Journal of cardiovascular pharmacology |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The incidence of pulmonary embolism, deep venous thrombosis, major bleeding (MB), clinically relevant non-MB, acute
respiratory distress syndrome, and in-hospital mortality was compared between patients on fondaparinux versus enoxaparin therapy. The 2 groups were homogeneous for demographic, laboratory, and clinical characteristics. In a median follow-up of 28 (IQR: 12–45)
days, no statistically significant difference in venous thromboembolism (14.5% vs. 5.3%; P = 0.20), MB and clinically relevant non-MB (3.2% vs. 5.3%, P = 0.76), ARDS (17.7% vs. 15.8%; P = 0.83), and in-hospital mortality (9.7% vs. 10.5%; P = 0.97) has been
shown between the enoxaparin group versus the fondaparinux group. Our preliminary results support the hypothesis of a safe and effective use of fondaparinux among patients with COVID-19 hospitalized in internal medicine units. |
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Arrhythmogenic syncope leading to cardiac rhythm management procedures during COVID-19 lockdown |
Russo, V, Pafundi, et al |
Expert Rev Med Devices |
Healthcare Response | Réponse des soins de santé |
Data were sourced from 14 referral hospitals in Campania from 10th March to 4th May 2020 (lockdown period) and during
the same period in 2019. Among consecutive patients hospitalized for CRM procedures during the two observational periods, we retrospectively evaluated those admitted for arrhythmogenic syncope. Admission rate and the type of hospital admission between the
two observational periods were compared.The hospitalization for arrhythmogenic syncope leading to CRM procedures increased during COVID-19 lockdown. |
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SARS-CoV-2 M(pro) inhibitors and activity-based probes for patient-sample imaging |
Rut, W, Groborz, et al |
Nat Chem Biol |
Coronavirology| Coronavirologie |
We have synthesized a combinatorial library of fluorogenic substrates with glutamine in the P1 position. We used it
to determine the substrate preferences of the SARS-CoV and SARS-CoV-2 main proteases. On the basis of these findings, we designed and synthesized a potent SARS-CoV-2 inhibitor (Ac-Abu-dTyr-Leu-Gln-VS, half-maximal effective concentration of 3.7 µM) and two
activity-based probes, for one of which we determined the crystal structure of its complex with the SARS-CoV-2 Mpro. |
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COVID-19 detection for chest X-ray images using local binary pattern |
Sabri, N, Hamzah, et al |
International Journal of Emerging Trends in Engineering Research |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The automatic feature CT analysis can help physicians more precisely in the treatment and diagnosis of diseases. In
this research, Local Binary Pattern (LBP) texture features algorithm has been proposed to automate the current manual approach. To prove the accuracy of LBP, a simple classifier k-Nearest Neighbour (k-NN) has been implement to classify the chest x-ray images
into normal, bacterial and pneumonia class. The 10-fold cross validation has been used to validate the chest x-ray images. From the evaluation, 96% accuracy can be achieved by using LBP as a feature extraction feature. It shows that LBP is a powerful texture
features to detect COVID-19 from the x-ray images. |
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32757981; In silico Potential of Approved Antimalarial Drugs for Repurposing Against COVID-19 |
Sachdeva, C, Wadhwa, et al |
Omics : a journal of integrative biology |
Therapeutics| Thérapeutique |
Authors report here new findings on the in silico potential of several antimalarial drugs for repurposing against COVID-19.
We conducted analyses by docking the compounds against two SARS-CoV-2–specific targets: (1) the receptor binding domain spike protein and (2) the main protease of the virus (MPro) using the Schrödinger software. Importantly, the docking analysis revealed that
doxycycline (DOX) showed the most effective binding to the spike protein of SARS-CoV-2, whereas halofantrine and mefloquine bound effectively with the main protease among the antimalarial drugs evaluated in the present study. The in silico approach reported
here suggested that DOX could potentially be a good candidate for repurposing for COVID-19. |
|
Sada, M, Saraya, et al |
Microorganisms |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Authors performed in silico studies to elucidate detailed molecular interactions between favipiravir and the SARS-CoV-2,
SARS-CoV, MERS-CoV, and influenza virus RNA-dependent RNA polymerases (RdRp). As a result, no interactions between favipiravir ribofuranosyl-5′-triphosphate (F-RTP), the active form of favipiravir, and the active sites of RdRps (PB1 proteins) from influenza
A (H1N1)pdm09 virus were found, yet the agent bound to the tunnel of the replication genome of PB1 protein leading to the inhibition of replicated RNA passage. In contrast, F-RTP bound to the active sites of coronavirus RdRp in the presence of the agent and
RdRp. Further, the agent bound to the replicated RNA terminus in the presence of agent, magnesium ions, nucleotide triphosphate, and RdRp proteins. These results suggest that favipiravir exhibits distinct mechanisms of action against influenza virus and various
coronaviruses. |
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Statin Use and In-Hospital Mortality in Diabetics with COVID-19 |
Saeed, O, Castagna, et al |
J Am Heart Assoc |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
An observational study of all consecutive adult patients with COVID‐19 admitted to a single‐center located in Bronx,
New York. Patients were grouped as those that did and did not receive a statin and in‐hospital mortality was compared by competing events regression. A total of 4,252 patients were admitted with COVID‐19. Patient with diabetes on a statin (n=983) were older
(69±11 vs. 67±14 years, p<0.01), had lower inflammatory markers (C‐reactive protein: 10.2, IQR: 4.5‐18.4 vs. 12.9, IQR: 5.9‐21.4 mg/dl, p<0.01) and reduced cumulative in‐hospital mortality (24% vs. 39%, p<0.01) than those not on a statin (n=1,283). Statin
use was associated with reduced in‐hospital mortality from COVID‐19 in patients with diabetes. |
|
Saeedi Saravi, SS, Barbagallo, et al |
Eur Heart J |
Clinical data| Données cliniques |
This is a case study of an 81-year-old gentleman presented with fever (39.1°C), cough, dysuria, and urinary tract infection,
which warranted antibiotic therapy. The patient was intubated and required mechanical ventilation for severe respiratory failure 6 days after hospitalization. SARS-CoV-2 polymerase chain reaction (PCR) test on nasopharyngeal swabs was positive and chest computed
tomography (CT) illustrated bilateral ground-glass opacities Laboratory tests showed a remarkable increase in the inflammatory cytokine interleukin-6. Kidney function compromised. The patient remained in the intensive care unit until recovery of pulmonary
function, but dialysis continued for 24 days to be prepared for discharge. Although causes of kidney disfuction are multifactorial, common mechanisms such as the proinflammatory cytokine storm, endothelial injury, hypercoagulability, and direct infection of
both endothelial and epithelial cells. |
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Perceived stress, parental stress, and parenting during covid-19 lockdown: A preliminary
study |
Sahithya, BR, Kashyap, et al |
Journal of Indian Association for Child and Adolescent Mental Health |
Public Health response| Interventions de santé publique |
The present study examined the stress experienced by parents during COVID-19 lockdown. Majority of the parents reported
moderate (63%) to high (4%) perceived stress since the COVID-19 lockdown, 37% reported feeling more stressed as a parent after the lockdown, and 8% of the parents said they needed to talk to a counsellor/psychologist. Mothers, parent of children with developmental
disorders, and parents who had interpersonal difficulties with spouse and children had significantly higher perceived stress and parental stress compared to parents without these difficulties. Both perceived stress and parental stress were significantly associated
with shouting, yelling or screaming, spanking or slapping the child, preoccupation with worries, and difficulty in focusing on parenting and disciplining the child, and excessive time on TV or video games in children. |
|
Salam, S, Mallat, et al |
Respiratory Medicine Case Reports |
Clinical data| Données cliniques |
While there are ongoing trials to demonstrate the efficacy of intermediate dosing against standard DVT prophylaxis
in the prevention of VTE, we present a 36-year-old male admitted with COVID-19 pneumonia who developed acute high-risk pulmonary embolism (PE) requiring emergent thrombolytic therapy despite intermediate dosing DVT prophylaxis. |
|
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Tocilizumab in nonventilated patients hospitalized with Covid-19
pneumonia |
Salama, Carlos, Han, et al |
medRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
Safety and efficacy of the anti-interleukin-6 receptor antibody tocilizumab was evaluated in patients hospitalized
with Covid-19 pneumonia. Nonventilated patients hospitalized with Covid-19 pneumonia were randomized (2:1) to tocilizumab (8 mg/kg intravenous) or placebo plus standard care. Of 389 randomized patients, 249 patients received tocilizumab and 128 received placebo
in the modified intent-to-treat population (Hispanic/Latino, 56.0%; Black/African American, 14.9%; American Indian/Alaska Native, 12.7%; White, 12.7%; other/unknown, 3.7%). The cumulative proportion (95% confidence interval [CI]) of patients requiring mechanical
ventilation or who had died by Day 28 was 12.0% (8.52% to 16.86%) and 19.3 % (13.34% to 27.36%) for the tocilizumab and placebo arms, respectively (log-rank P=0.0360; hazard ratio, 0.56 [95% CI, 0.33 to 0.97]). Median time to clinical failure up to Day 28
favored tocilizumab over placebo This trial demonstrated the efficacy and safety of tocilizumab over placebo in reducing the likelihood of progression to requiring mechanical ventilation or death in nonventilated patients hospitalized with Covid-19 pneumonia. |
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Detection of covid-19 in computed tomography (Ct) scan images using deep learning |
Saleh, AY, Ilango, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this article, a model of deep learning is being trained for the COVID-19 detection in CT Scan images. To build and
train the Convolution Neural Network (CNN) model, Python Deep Learning libraries such as Keras and TensorFlow 2.0 have been utilized. As for the dataset, the open source dataset of COVID-19 chest computed tomography (CT) images were used. There were total
of 745 images belonging to two classes were sampled. 348 positive (+) COVID-19 images and 397 negative (-) COVID-19 images. Based on the training process, the model was able to detect 79 per cent accuracy on the test set. Findings from the research proves
that Convolution Neural Network are reliable by producing higher accuracy rate of 79% while Logistic Regression produce a rate of 54%. |
|
Covid-19 in children: is there any correlation with renal function
and severity of the disease? |
Sambas, Dedi Rachmadi, Widiasta, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Kidney manifestations are life-threatening conditions, such as end-stage renal disease (ESRD), especially when attributed
to viral infections. This study aims to analyse the correlation between kidney manifestations with the renal function of pediatric patients suffering from COVID-19. An observational analytic study was conducted in Indonesia and The demographic data, clinical
signs, laboratory results, and notable kidney function were analysed, while the disease was classified as severe and nonsevere based on its clinical appearance. The median eGFR value in the severe group was lower (49.59 ml / minute / 1.73m2) compared to the
nonsevere (113 ml / minute / 1.73m2), however, not statistically significant (p = 0.521). A severe SARS-CoV-2 infection tends to affect the kidney, which is manifested as decreased glomerular filtration rate (GFR). |
|
32769803; Nurses' Mental Health During the Covid-19 Outbreak: A Cross-Sectional Study |
Sampaio, F, Sequeira, et al |
Journal of occupational and environmental medicine |
Healthcare Response | Réponse des soins de santé |
We describe nurses’ mental health status during the Covid-19 outbreak and to explore the factors that might accentuate
the negative consequences on their mental health. Our results suggest that nurses’ mental health status seems to be particularly affected by the Covid-19 outbreak and that some modifiable elements might accentuate the impacts on their mental health. |
|
Spine Patient Satisfaction With Telemedicine During the COVID-19 Pandemic: A Cross-Sectional Study |
Satin, AM, Shenoy, et al |
Global Spine J |
Healthcare Response | Réponse des soins de santé |
We evaluate patient satisfaction with spine care delivered via telemedicine. Identify patient- and visit-based factors
associated with increased satisfaction and visit preference. |
|
Savi, PV, Savi, et al |
Computational and mathematical methods in medicine |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This paper deals with the mathematical modeling and numerical simulations related to the coronavirus dynamics with
data from China, Italy, Iran, and Brazil. A description is developed based on the framework of the susceptible-exposed-infectious-removed model. Numerical simulations are performed in order to analyze different scenarios of COVID-19 in Brazil. Results show
the importance of the governmental and individual actions to control the number and the period of the critical situations related to the pandemic. |
|
|
Schulman, JosephD, Cooper, et al |
medRxiv |
Public Health response| Interventions de santé publique |
An electronic survey was conducted in October, 2020 among individuals primarily age 60 and older regarding their degree
of confidence of deriving personal protection from 8 different anti‐COVID interventions – social isolation, lockdowns, avoiding restaurants, taking MMR vaccine, wearing masks when indoors with others, avoiding hotels, avoiding commercial air travel, and using
the first future specific anti‐COVID vaccine. Responses were received from 135 persons from many different U.S. regions and 5 foreign countries. None were strongly supported by a majority of respondents, but those receiving the largest proportions of strong
support were social isolation (41%), wearing masks indoors (41%), and using the first anti‐COVID vaccine (41%). |
|
|
Sehanobish, Esha, Barbi, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study we examined factors associated with anosmia and ageusia and the recovery from these symptoms in an ethnically
diverse cohort. Among 486 COVID-19 patients, 33% and 50% reported anosmia and ageusia, respectively. Systemic symptoms (fever, body aches, fatigue, headache) respiratory symptoms (cough, sore throat), and diarrhea were each reported significantly more frequently
among patients who also had anosmia and/or ageusia. |
|
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Shah, P, Smith, et al |
Crit Care Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We describe the characteristics and outcomes of in-hospital cardiac arrest in coronavirus disease 2019 patients in
rural Southwest Georgia. Out of 1,094 patients hospitalized for coronavirus disease 2019 during the study period, 63 patients suffered from in-hospital cardiac arrest with attempted resuscitation and were included in this study. In our study, coronavirus disease
2019 patients suffering from in-hospital cardiac arrest had 100% in-hospital mortality regardless of the baseline comorbidities, presenting illness severity, and location of arrest. |
|
|
Shan, W, Hong, et al |
Computational and mathematical methods in medicine |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Out of 1,094 patients hospitalized for coronavirus disease 2019 during the study period, 63 patients suffered from
in-hospital cardiac arrest with attempted resuscitation and were included in this study. A total of 55 safety signals were detected from the top 250 adverse event reactions in 2200 reports, but 19 signals were not included in the drug labels. |
|
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Computer-aided drug design against spike glycoprotein of SARS-CoV-2 to aid COVID-19 treatment |
Shehroz, M, Zaheer, et al |
Heliyon |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The current study was conducted to explore drugs against Receptor Binding Domain (RBD) of SARS-CoV-2 using in silico
pharmacophore modelling and virtual screening approach to combat COVID-19. The Receptor Binding Motif (RBM) region of S interacts with Angiotensin Converting Enzyme 2 (ACE2) receptor and Glucose Regulated Protein 78 (GRP78) to mediate viral entry. |
|
Shrivastava, P, Prashar, et al |
Transplantation |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We report our experience with a predominantly African American (AA) cohort (79%) of kidney transplant recipients (KTRs)
with COVID-19 infections in the Detroit Metropolitan area. Final analysis of acute kidney injury (AKI) in KTRs with proven COVID-19 was done on 38 patients of which 30 were AA (79%). AKI occurred in 71.1% of COVID-19 KTRs (n=27), of whom 6 (22.2%) patients
required HD. |
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Shukla, Meenakshi, Pandey, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
Here we report on experiences of coronavirus and its’ impact on negative emotions and worries in Indian adolescents.
Three-hundred-and-ten young people from North India (51% male, 12-18 years) were recruited to a longitudinal online survey. Indian adolescents report significant impact of the pandemic on various aspects of their life and are particularly worried about academic
attainments, social and recreational activities and physical health. |
|
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No lockdown policy for COVID-19 epidemic in Bangladesh: Good, bad
or ugly? |
Siam, Zakaria Shams, Arifuzzaman, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this study, we assess the impact of lift of flexible lockdown on the COVID-19 dynamics in Bangladesh. Our analysis
demonstrates that the country might experience second infection peak in 6-7 months after the withdrawal of current lockdown. Moreover, a prolonged restriction until January, 2021 will shift the infection peak towards August, 2021 and will reduce approximately
20 % COVID-19 cases in Bangladesh. |
|
Sii, SSZ, Chean, et al |
Eye (Lond) |
Public Health response| Interventions de santé publique |
The aim of this survey is to determine patients’ perceptions while waiting for cataract surgery during the pandemic
and their willingness to have their operation following the easing of lockdown. Our survey showed that the current pandemic did not affect patients’ decision to attend hospital for cataract surgery as 83.3% indicated their willingness to come for cataract
surgery. Our survey showed that patients who reported worse VRQoL and higher level of concern regarding delay were more likely to have a MAWT <3 months, which is statistically significant (p < 0.05). |
|
|
Silies, K, Schley, et al |
Pflege |
Healthcare Response | Réponse des soins de santé |
AIM: The aim of this study was to explore how acute inpatient care was influenced by the pandemic and which implications
may result for the future from nursing managers' and hygiene specialists' point of view. METHODS: Qualitative study based on semi-structured interviews with five nursing managers and three hygiene specialists in four German acute care hospitals. Interviews
were interpreted by using content analysis. RESULTS: Interviewees described how everyday routines in their hospitals were adapted to the prioritized care for COVID-19 patients. Main challenges were uncertainty and anxiety among staff, relative scarcity of
equipment and workforce resources and rapid implementation of new requirements for treatment capacities. |
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33031083; Forecasting daily confirmed COVID-19 cases in Malaysia using ARIMA models |
Singh, S, Murali Sundram, et al |
Journal of infection in developing countries |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The aim of this study is firstly to develop a prediction model for daily confirmed COVID-19 cases based on several
covariates, and secondly, to select the best prediction model based on a subset of these covariates. This study was conducted using daily confirmed cases of COVID-19 collected from the official Ministry of Health, Malaysia (MOH) and John Hopkins University
websites. This study finds that ARIMA models with optimally selected covariates are useful tools for monitoring and predicting trends of COVID-19 cases in Malaysia. |
|
Siu, HY, Kristof, et al |
BMC Geriatr |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
An online cross-sectional survey of Ontario LTC Clinicians working in LTC homes in Ontario Canada was conducted to
provide the clinician perspective on the preparedness and engagement of the LTC sector during the COVID-19 pandemic. The overall response rate was 54% (160/294). LTC homes implemented a wide range of important interventions (e.g. instituting established respiratory
isolation protocols, active screening of new LTC admissions, increasing education on infection control processes, encouraging sick staff to take time off, etc). This study highlights the communication and implementation of recommendations in the Ontario LTC
sector, despite some concerns regarding feasibility. |
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|
Skorin, I, Carrillo, et al |
Seizure |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Our objective is to describe the most prevalent electroencephalographic findings in COVID-19 hospitalized patients,
and to determine possible predictors of mortality including EEG and clinical variables. We observed that the most prevalent EEG finding in this cohort was generalized continuous slow-wave activity, while epileptic activity was observed in less than 20 % of
the cases. Mortality risk factors were comorbidity with cancer and requiring an EEG during the third week of evolution, possibly related to the hyperinflammatory state. |
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Induction of Labor in an Intubated Patient With Coronavirus Disease 2019 (COVID-19) |
Slayton-Milam, S, Sheffels, et al |
Obstet Gynecol |
Clinical data| Données cliniques |
A 27-year-old pregnant woman was admitted to a 166-bed community hospital at 33 weeks of gestation with acute hypoxemic
respiratory failure secondary to COVID-19. She underwent mechanical ventilation for 9 days. While ventilated, she underwent induction of labor, resulting in a successful forceps assisted-vaginal birth. She was extubated on postpartum day 5 and discharged on
postpartum day 10. The neonate was intubated for 24 hours but was otherwise healthy and discharged home at 36 2/7 weeks postmenstrual age. |
|
Soeroto, AY, Hartantri, et al |
Acta medica Indonesiana |
Clinical data| Données cliniques |
This case series report two confirmed COVID-19 patients who had met criteria of intubation and mechanical ventilation,
but not performed to them. Both patients experienced clinical improvement and recovery. Probably this is due to differences of COVID-19 ARDS (CARDS) with typical or classic ARDS. |
|
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The role of lung ultrasound as a frontline diagnostic tool in the era of COVID-19 outbreak |
Sorlini, C, Femia, et al |
Intern Emerg Med |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In the present study, we evaluated the diagnostic accuracy of lung point-of-care ultrasound (POCUS) for SARS-CoV-2
pneumonia in a cohort of symptomatic patients admitted to one emergency department (ED) in a high-prevalence setting. Of the 444 symptomatic patients who were admitted to the ED in the study period, the result of the lung POCUS test was available for 384 (86.5%).
The sensitivity of the test was 92.0% (95% CI 88.2–94.9%), and the specificity was 64.9% (95% CI 54.6–74.4%). Lung POCUS is a sensitive first-line screening tool for ED patients presenting with symptoms suggestive of SARS-CoV-2 infection. |
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COVID-19 and financial toxicity in patients with renal cell carcinoma |
Staehler, MD, Battle, et al |
World J Urol |
Public Health response| Interventions de santé publique Economics | Économie |
We ascertain renal cell carcinoma (RCC) financial toxicity on COVID-19 during the COVID-19 crisis as patients are struggling
with therapeutic and financial implications. Five-hundred-and-thirty-nine patients (39%:58% male:female) from 14 countries responded. 23% of the patients did not feel in control of their financial situation but 8% reported being very satisfied with their finances.
Our data highlight severe financial impact of COVID-19. Acknowledging financial hardship and thorough counseling of cancer patients should be part of the conversation during the pandemic. |
|
Šterbenc, A, Premru Sršen, et al |
J Perinat Med |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We retrospectively reviewed the Ljubljana Maternity Hospital database and searched for pregnant women, who were admitted
to the hospital between March 15 and May 16, 2020, for a planned procedure or hospitalization. Their medical records were examined and SARS-CoV-2 test results were retrieved. We assessed the usefulness of screen-and-test strategies of pregnant women for SARS-CoV-2.
In a population with a low SARS-CoV-2 burden, usefulness of universal testing of pregnant women before admission to the hospital is limited. We recommend that obstetric units in regions with low SARS-CoV-2 burden enforce rational use of personal protective
equipment and diligent screening protocols using targeted questionnaires. |
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Strang, P, Fürst, et al |
Upsala journal of medical sciences |
Epidemiology| Épidémiologie |
We aimed to study excess deaths (all death causes, but also COVID-19-related deaths) during the COVID-19 pandemic regarding
age, socio-economic status, the situation in nursing homes, and place of death for nursing home residents. Compared with 2016–2019, there were excess deaths in March–May 2020 (p < 0.0001), mainly explained by COVID-19, but in April there were also unexplained
excess deaths. Individuals dying from COVID-19 were older than patients dying from other causes (p < 0.0001). |
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Epidemiology of COVID-19 in Mexico: from the 27th of February to the 30th of April 2020 |
Suárez, V, Suarez Quezada, et al |
Revista clinica espanola |
Epidemiology| Épidémiologie |
In response to this global outbreak, we summarize the current state of our understanding regarding COVID-19 in Mexico.
In Mexico, most cases of COVID-19 were located in Mexico City. The mean age of the patients was 46 years. Of the 12 656 confirmed cases, most infected individuals were between the ages of 30 and 59 years (65.85%), and there was a higher incidence rate in men
(58.18%) than in women (41.82%). The patients who died had one or more comorbidities, mainly hypertension (45.53%), diabetes (39.39%) and obesity (30.4%). In the first 64 days of the epidemic, China had reported 80 304 cases with a mortality rate of 3.66%. |
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Managing cancer during COVID pandemic – Experience of a tertiary cancer care center |
Subbiah, S, Hussain, et al |
European Journal of Surgical Oncology |
Healthcare Response | Réponse des soins de santé |
Experience of evolving “COVID 19 PROTOCOL” devised in an Oncology department in Mexico with a limited budget. |
|
Swargiary, A, Mahmud, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Investigates the binding affinity of phytocompounds with 3-Chymotrypsin-like (3CLpro) and Papain-like proteases (PLpro)
of SARS-CoV2 using in-silico techniques. The study suggests Amentoflavone and Gallocatechin gallate may be potential inhibitors of 3CLpro and PLpro proteins and effective drug candidates for SARS-CoV2. |
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Evidence for secondary thrombotic microangiopathy in COVID-19 |
Sweeney, Joseph, Barouqa, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Investigate the relationship between markers of endothelial activation, intravascular hemolysis, coagulation, and organ
damage in COVID-19 patients and association with disease severity and mortality (n=181). Patients who died had significantly lower ADAMTS13 activity, significantly higher LDH, schistocytes and von Willebrand Factor levels compared to patients discharged alive.
Only 30% of patients with an initial ADAMTS13 activity <43% survived vs. 60% with ADAMTS13 >43% who survived. |
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Tantrakarnapa, K, Bhopdhornangkul, et al |
One Health |
Epidemiology| Épidémiologie |
The spread of the disease in Thailand was associated with social activities, the enforcement by regulation and partnership
among the organization are the key roles for spreading control. |
|
|
Tariq, S, Tariq, et al |
Disaster Med Public Health Prep |
Public Health response| Interventions de santé publique |
Survey findings suggest knowledge score among our study population was not up to the mark. However, a positive correlation
between the correct knowledge and appropriate attitude and practice was found among study participants. Older age groups and the group of high income were associated with adequate knowledge scores. |
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|
Teofili, L, Landolfi, et al |
Trials |
RCT |
The primary objective is to demonstrate that COVID-19 convalescent plasma (CCP) prevents progression to severe pneumonia
in elderly COVID-19 pneumonia patients with chronic comorbidities. |
|
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Time-lapse sentinel surveillance of SARS-CoV-2 spread in India |
Thakur, M, Singh, et al |
PLoS One |
Coronavirology| Coronavirologie |
Analysed 112 complete genomes of SARS-CoV-2 in a time-lapse manner and found 72 distinct SARS-CoV-2 haplotypes, defined
by 143 polymorphic sites and high haplotype diversity, suggesting the virus possesses a high evolutionary potential. |
|
Tramarin, Andrea, Gennaro, et al |
medRxiv |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
The investigators estimate of the impact of COVID-19 on Long-term Care Facilities (LTCFs) by combining retrospective
data and a prospective cohort in Italy, An age-gradient in all variables explored was identified and an observed mortality 60% greater than 2019 was identified among sites reporting COVID-19 cases. The findings suggest the need to adopt and maintain strict
mitigation measures in LTCFs in the future dynamics of the epidemic |
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Turan, TN, Meschia, et al |
Journal of Stroke and Cerebrovascular Diseases |
Healthcare Response | Réponse des soins de santé RCT |
Performed a study to evaluate the feasibility of a home-based program for testing blood pressure (BP) and low-density
lipoprotein (LDL) in CREST2 trial participants. CREST2 is comparing intensive medical management alone versus intensive medical management plus revascularization with endarterectomy or stenting. |
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Uddin, MN, Amin, et al |
Applied Organometallic Chemistry |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Molecular docking revealed that tested Schiff base possessed high binding affinity with the receptor protein of SARS
CoV‐2 compared with hydroxychloroquine (HCQ). The ADMET analysis showed that ligand is non‐carcinogenic and less toxic than standard HCQ. Schiff bases acting as dibasic tetra‐dentate ligands formed titanium (IV) complexes of the type [TiL(H2O)2Cl2] or [TiL(H2O)2]Cl2
being coordinated through ONNO donor atoms. |
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32971109; Elevated plasma sTIM-3 levels in patients with severe COVID-19 |
Ueland, T, Heggelund, et al |
Journal of Allergy and Clinical Immunology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Examined the parameters of activation of different leukocyte subsets in COVID-19–infected patients in relation to disease
severity. Findings include : (1) severe clinical outcome (ICU treatment) was associated with high plasma levels of sTIM-3 and myeloperoxidase, suggesting activated and potentially exhausted T cells and activated neutrophils, respectively; (2) in contrast,
sCD14 and sCD163 showed no association with need for ICU treatment; and (3) levels of sCD25, sTIM-3, and myeloperoxidase were inversely correlated with degree of respiratory failure, as assessed by the ratio of Pao2 to fraction of inspired oxygen, and were
positively correlated with the cardiac marker N-terminal pro-B–type natriuretic peptide. |
|
Unni, S, Aouti, et al |
Journal of Biosciences |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The study identified a laxative drug, Bisoxatin (DB09219), which is used for the treatment of constipation and preparation
of the colon for surgical procedures. It binds nicely at the S-protein–ACE2 interface by making substantial π-π interactions with Tyr505 in the ‘Site 1’ hook region of RBD and hydrophilic interactions with Glu406, Ser494, and Thr500. Bisoxatin consistently
binds to the protein throughout the 100 ns simulation. the discovered molecule, Bisoxatin may be a promising repurposable drug molecule to develop new chemical libraries for inhibiting SARS-CoV-2 entry into the host. |
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Vauloup Fellous, Christelle, Maylin, et al |
SSRN- Lancet prepublication |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Serum samples of RT-PCR SARS-CoV-2 positive patients (n=2594) were tested for IgM/IgG/IgA against the virus using 31
commercial assays. Rapid tests for qualitative detection of anti-SARS-CoV-2 antibodies (RDTs) achieved 77.4-100%, and ELISA/CLIA (ELISA) assays 58.8-100% for SARS-CoV-2-specific total antibodies (TAb) specificity. From 15 days after onset of symptoms, 13/18
RDT and 8/13 ELISA reached sensitivity > 90%. Contrasted performances were observed among the commercial assays evaluated. |
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Coding-Complete Genome Sequences of 23 SARS-CoV-2 Samples from the Philippines |
Velasco, JM, Chinnawirotpisan, et al |
Microbiol Resour Announc |
Coronavirology| Coronavirologie |
Report the coding-complete genome sequences of 23 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) samples
from the Philippines. |
|
Immunogenicity of a new gorilla adenovirus vaccine candidate for
COVID-19 |
Vitelli, Alessandra, Capone, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins |
Report the generation and the preclinical evaluation of a novel replication-defective gorilla adenovirus-vectored vaccine
encoding the pre-fusion stabilized Spike (S) protein of SARS-CoV2 (GRAd-COV2). Reports GRAd-COV2, is highly immunogenic both in mice and macaques, eliciting both functional antibodies which neutralize SARS-CoV-2 infection and block Spike protein binding to
the ACE2 receptor, and a robust, Th1-dominated cellular response in the periphery and in the lung. |
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Socioeconomic status and well-being during COVID-19: A resource-based examination |
Wanberg, CR, Csillag, et al |
J Appl Psychol |
Public Health response| Interventions de santé publique |
Assess overall and within-person changes in psychological well-being (i.e., depressive symptoms and life satisfaction)
from before to during the COVID-19 pandemic using data from two surveys (n=1143) conducted in spring 2019 and 2020. Depressive symptoms during the pandemic were higher than population norms before the pandemic. Depressive symptoms increased from before to
during COVID-19 and life satisfaction decreased. Individuals with higher education experienced a greater increase in depressive symptoms and a greater decrease in life satisfaction from before to during COVID-19 in comparison to those with lower education.
Individuals at the highest levels of income experienced a greater decrease in life satisfaction from before to during COVID-19 than individuals with lower levels of income |
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Decoding COVID-19 pneumonia: comparison of deep learning and radiomics CT image signatures |
Wang, H, Wang, et al |
Eur J Nucl Med Mol Imaging |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Compare feature engineering and deep learning methods to gain insights into the image features that drive CT-based
for COVID-19 pneumonia prediction, and uncover CT image features significant for COVID-19 pneumonia from deep learning and radiomics framework. |
|
Wang, J, Zhang, et al |
Chinese General Practice |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The objective of this study was to develop a PCR-Time-of-flight mass spectrometry method (TOFMS) for detecting SARS-CoV-2
nucleic acid based on Clin-ToF-II TOFMS system using matrix-assisted laser desorption/ionization(MALDI) principle, and evaluate its practical application value. The combination of PCR and TOFMS technology makes the detection of SARS-CoV-2 target fragment
expand exponentially, thereby improving the detection sensitivity of samples.In addition, MALDI-TOF MS technology has high accuracy and specificity through the detection and analysis of ion molecular weight, which also confirms that sputum sample is better
than throat swab sample for detection. |
|
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Lessons from a patient with severe aplastic anemia complicated with COVID-19 |
Wang, Y, Lu, et al |
Asian Journal of Surgery |
Clinical data| Données cliniques |
A 53-year-old female patient was admitted to the hospital and diagnosed with COVID-19, accompanied with sepsis and
severe aplastic anemia. However, the patient died within 24 h after shock occurred. This case report reminds us that atypical or even asymptomatic manifestations of COVID-19 may be disguised by inherent diseases. |
|
Widhani, A, Rengganis, et al |
Acta medica Indonesiana |
Public Health response| Interventions de santé publique |
This study aimed to know autoimmune patients' knowledge, perception, and practices regarding COVID-19. Almost all respondents
had good knowledge and practices regarding COVID-19. Adequacy of information, autoimmune treatment, work from home, educational background, area of living, and health care facilities contributed to perception regarding COVID-19 pandemic. |
|
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Wildgruber, D, Frey, et al |
Pflege |
Healthcare Response | Réponse des soins de santé |
With a cross-sectional design, German health professionals were asked about their stress experience, health concerns
and work commitment. The evaluation shows that health professionals in direct contact with COVID-19 patients show higher stress levels than participants with no contact and that their main concern is about the health of relatives, friends and family. In addition,
it was found that the participants' work commitment decreased parallel to the increase in pandemic-related stress. |
|
|
Willforss, Jakob, Siino, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Visual exploration of gene product behavior across multiple omic datasets can pinpoint technical limitations in data
and reveal biological trends. The OmicLoupe software was developed to facilitate such exploration and provides more than 15 interactive cross-dataset visualizations for omic data. The usage of OmicLoupe is demonstrated in three diverse studies, including
an analysis of SARS-CoV-2 infection across omic layers, based on previously published proteomics and transcriptomics studies. |
|
|
Wolf-Ostermann, K, Schmidt, et al |
Pflege |
Healthcare Response | Réponse des soins de santé |
AIM: The study aims to illustrate (I) to what extent home care services and semi-residential care facilities are affected
by COVID-19. METHODS: More than 12,000 home-care nursing services and semi-residential care facilities were invited to participate in an online survey with quantitative and qualitative elements, 701 nursing services (response rate 7,3 %) and 96 semi-residential
facilities (response rate 3,5 %) took part. RESULTS: Almost a third (30,1 %, 189 / 627) of the nursing services surveyed are affected by confirmed or suspected cases of COVID-19 among clients. |
|
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Broadly-targeted autoreactivity is common in severe SARS-CoV-2
Infection |
Woodruff, Matthew, Ramonell, et al |
medRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
We retrospectively collected data from 31 critically ill patients with COVID-19 and no known history of autoimmunity
undergoing treatment between June 1st and July 2nd, 2020 in two academic intensive care units in Atlanta, Georgia, USA. We identify autoreactive antibodies as a common feature of severe COVID-19, identifying biomarkers of tolerance breaks that may indicate
aggressive immunomodulation. |
|
Xiong, S, Liu, et al |
BMC Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study analyses cardiovascular implications of COVID-19 patients. In this single-centered, retrospective, observational
study in Wuhan, China, we found that the infection of SARS-CoV-2 was more likely to occur in middle and aged population with cardiovascular comorbidities. Cardiovascular complications, including new onset hypertension and heart injury were common in severe
patients with COVID-19. |
|
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Non-compulsory measures sufficiently reduced human mobility in Tokyo during the COVID-19 epidemic |
Yabe, T, Tsubouchi, et al |
Sci Rep |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
We analyze the temporal changes in human mobility behavior, social contact rates, and their correlations with the transmissibility
of COVID-19, using mobility data collected from more than 200K anonymized mobile phone users in Tokyo. The analysis concludes that by April 15th, human mobility behavior decreased by around 50%, resulting in a 70% reduction of social contacts in Tokyo, showing
the strong relationships with non-compulsory measures. Furthermore, the reduction in data-driven human mobility metrics showed correlation with the decrease in estimated effective reproduction number of COVID-19 in Tokyo. |
|
Yamamura, E, Tsutsui, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique Economics | Économie |
The 2020 Tokyo Olympics have been postponed due to the novel coronavirus (COVID-19) pandemic. Postponement of the sporting
event is likely to have a significant impact on their happiness level and expected income. We independently collected individual-level panel data from March to April 2020. We found that the happiness level of workers in the tourism and restaurant sectors declined
drastically after the announcement of the postponement. Only two weeks later, their happiness level did not alter from the pre-announcement level. However, workers engaged in the tourism and restaurant sectors did not predict a decrease in their income even
after the postponement. |
|
|
Broad transcriptional dysregulation of brain and choroid plexus cell
types with COVID-19 |
Yang, Andrew Chris, Kern, et al |
bioRxiv |
Clinical data| Données cliniques |
We profile 47,678 droplet-based single-nucleus transcriptomes from the frontal cortex and choroid plexus across 10
non-viral, 4 COVID-19, and 1 influenza patient. We complement transcriptomic data with immunohistochemical staining for the presence of SARS-CoV-2. We find that all major cortex parenchymal and choroid plexus cell types are affected transcriptionally with
COVID-19. |
|
Uncovering two phases of early intercontinental COVID-19 transmission dynamics |
Yang, J, Li, et al |
J Travel Med |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Coronavirology|
Coronavirologie |
We performed two independent analyses, travel network-based epidemiological modelling and Bayesian phylogeographic
inference, to investigate the intercontinental spread of COVID-19. In the first phase, COVID-19 largely circulated in China during mid- to late January, 2020, and was interrupted by containment measures in China. In the second and predominant phase extending
from late February to mid-March, unrestricted movements between countries outside of China facilitated intercontinental spread, with Europe as a major source. Phylogenetic analyses also revealed that the dominant strains circulating in the United States of
America were introduced from Europe. However, stringent restrictions on international travel across the world since late March have substantially reduced intercontinental transmission. |
|
32912875; Clinical and neuroimaging correlation in patients with COVID-19 |
Yoon, BC, Buch, et al |
American Journal of Neuroradiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective study performed at a large academic hospital in the United States, they examined the frequency
of acute intracranial abnormalities seen on CT and/or MR imaging in patients with COVID-19 and investigated possible associations between these findings and clinical parameters. A spectrum of acute neuroimaging abnormalities was seen in the cohort of patients
with coronavirus disease 2019, including hemorrhage, infarction, and leukoencephalopathy. Significant associations between abnormal neuroimaging studies and markers of disease severity (intensive care unit admission, intubation, and acute kidney injury) suggest
that patients with severe forms of coronavirus disease 2019 may have higher rates of neuroimaging abnormalities. |
|
Covidom, a Telesurveillance Solution for Home Monitoring Patients With COVID-19 |
Yordanov, Y, Dechartres, et al |
J Med Internet Res |
Healthcare Response | Réponse des soins de santé |
This study presents a telesurveillance solution-Covidom-deployed in the greater Paris area to monitor patients with
COVID-19 in their homes. The Covidom solution combines an easy-to-use and free web application for patients (through which patients fill out short questionnaires on their health status) with a regional control center that monitors and manages alerts (triggered
by questionnaire responses) from patients whose health may be deteriorating. During follow-up, patients triggered 21,873 red alerts and 211,160 orange alerts. As of May 19, 72.0% (34,767/48,290) of patients had their follow-up terminated, 1.1% (544/48,290)
had been hospitalized or rehospitalized, and 0.1% had died (39/48,290) |
|
Exposing Empirical Links between COVID-19 Situation Report and Available Data: The Case of Nigeria |
Zakariya, YF |
Diseases |
Epidemiology| Épidémiologie |
This cross-sectional study explores the Nigerian COVID-19 report to expose some links between the number of confirmed
cases, testing, and some environmental conditions. The findings reveal that there is no state in Nigeria which has up to 12 confirmed cases per 10,000 population. On the flip side, it was revealed that the proportion of samples tested for COVID-19 is low compared
to the population. There is a substantial correlation between the confirmed cases and testing. |
|
Zhang, Kexin, Yang, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
We compared the differences of healthcare workers infection (HWI) during the COVID-19 epidemic in two countries, Italy
and South Korea. The results indicated that HWI presented a same trend with total infection in both Italy and South Korea, meanwhile, Italy had a higher proportion of HWI among the general population. And the intensity approach to assess the healthcare pressure
was correlated with cumulative HWI (both number and rate) and the magnitude approach performed correlation with increased cases only in Italy. |
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Zhang, Y, Cao, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
Based on data envelopment analysis (DEA), this article used community worker data to evaluate the matching of service
supply and demand during the epidemic period and used co-word analysis to analyze the content and the residents' demands for community service from the threshold period to the normal period of the epidemic. -According to the results of the DEA model, early
in the epidemic, 13 of the 15 districts' DEA values were invalid, indicating that there was a shortage in community workers in Wuhan. The results of public opinion analysis showed that the emphasis on community service gradually transformed from epidemic prevention
to an integrated service. |
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Clinical Characteristics of Overseas Imported and Local COVID-19 Cases in Hebei Province |
Zhao, L, Qin, et al |
Chinese General Practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective was to study the clinical characteristics of overseas imported and local COVID-19 cases in Hebei Province,
to provide a reference for developing targeted programs to prevent the recurrence of the pandemic. In Hebei Province, the imported COVID-19 cases showed milder symptoms, lower Ct values of SARS-CoV-2 N gene and ORF1ab gene and higher SARS-CoV-2 viral nucleic
acids from nasopharyngeal swabs, which indicate that the virus from imported cases may be more contagious. |
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Single-cell analysis identified lung progenitor cells in COVID-19 patients |
Zhao, Z, Zhao, et al |
Cell Prolif |
Clinical data| Données cliniques |
We focused on crucial roles of lung progenitor cells in alveolar cell regeneration and epithelial barrier re‐establishment
and aimed to uncover a possible mechanism of lung repair after severe SARS‐CoV‐2 infection. In severe (or critical) COVID-19 patients, there is a remarkable expansion of TM4SF1+ and KRT5+ lung progenitor cells. The two distinct populations of progenitor cells
could play crucial roles in alveolar cell regeneration and epithelial barrier re-establishment, respectively. |
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Zhou, Xianlong, Liu, et al |
SSRN- Lancet prepublication |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In the present study, the retrospective data of COVID-19 and influenza patients from two large teaching hospitals in
Wuhan, China were input to a machine learning based-modeling approach to develop a tool devoted to distinguishing between these two diseases. In the training and testing sets, the model achieved good performance in identifying COVID-19 from influenza with
an accuracy of 0.968 and 0.960, respectively. Our decision tree suggested that older age (>16 years), higher hsCRP and lower monocyte drive the prediction towards COVID-19. In addition, the external test determined a COVID-19 prediction accuracy of 0.839 |
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Aki, ÖE |
Turk Geriatri Dergisi |
Review Literature| Revue de littérature |
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Alothaid, H, Aldughaim, et al |
Channels (Austin) |
Review Literature| Revue de littérature |
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Alsulaiman, JW, Khasawneh, et al |
Journal of infection in developing countries |
Review Literature| Revue de littérature |
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Effect of awake prone positioning in COVID-19 patients- A systematic review |
Anand, S, Baishya, et al |
Trends in Anaesthesia and Critical Care |
Review Literature| Revue de littérature |
SR: systematic search of 2 medical databases (PubMed, Google Scholar) was performed until July 5, 2020. Awake prone
positioning demonstrated an improvement in oxygenation of the patients suffering from COVID-19 related respiratory disease. Need for intubation was observed in less than 30% of the patients.
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Anastassopoulou, C, Gkizarioti, et al |
Hum Genomics |
Review Literature| Revue de littérature |
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32716648; The Novel Insight of SARS-CoV-2 Molecular Biology and Pathogenesis and Therapeutic Options |
Asghari, A, Naseri, et al |
DNA and cell biology |
Review Literature| Revue de littérature |
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Batista, RCS, Arruda, et al |
TheScientificWorldJournal |
Review Literature| Revue de littérature |
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Bloom, K, van den Berg, et al |
Gene Ther |
Review Literature| Revue de littérature |
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Brandi, ML, Giustina, et al |
Trends in Endocrinology and Metabolism |
Review Literature| Revue de littérature |
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Brewster, RK, Sundermann, et al |
Toxicology and industrial health |
Review Literature| Revue de littérature |
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Bwire, GM, Njiro, et al |
J Med Virol |
Review Literature| Revue de littérature |
SR: searched evidence from PubMed/ MEDLINE and Google Scholar. In conclusion, the current evidence revealed a low
possibility of vertical transmission of COVID-19 and antibodies against SARS-CoV-2 were detected among vertically exposed but negative infants. |
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Byambasuren, Oyungerel, Dobler, et al |
medRxiv |
Review Literature| Revue de littérature |
SR: searched PubMed, Embase, the Cochrane COVID-19 trials, and Europe-PMC for published studies and pre-prints that
reported anti-SARS-CoV-2 IgG, IgM and/or IgA antibodies for serosurveys of the general community from 1 Jan to 12 Aug 2020. The findings show SARS-CoV-2 seroprevalence is well below herd immunity in all countries studied. The estimated number of infections,
however, were much greater than the number of reported cases and deaths in almost all locations. |
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Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2 |
Carrouel, F, Gonçalves, et al |
J Dent Res |
Review Literature| Revue de littérature |
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Impacts of COVID-19 on a transitioning energy system, society, and international cooperation |
Chapman, A, Tsuji, et al |
Sustainability (Switzerland) |
Review Literature| Revue de littérature |
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Alternative clinical specimens for the detection of SARS-CoV-2: A rapid review |
Comber, L, Walsh, et al |
Rev Med Virol |
Review Literature| Revue de littérature |
Rapid Review: Searches were conducted in PubMed, Embase, Europe PMC and NHS evidence from December 2019 to 20 July
2020. The results indicate an inconsistency in the detection of SARS-CoV-2 RNA in the specimen types included, often with neither the index nor the reference of interest detecting all known cases. Depending on the test environment, these clinical specimens
may offer a viable alternative to standard. However, at present the evidence is limited, of variable quality, and relatively inconsistent. |
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da Silva, LCN, Mendonça, et al |
Glycobiology |
Review Literature| Revue de littérature |
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Airborne spread of infectious SARS-CoV-2: Moving forward using lessons from SARS-CoV and
MERS-CoV |
da Silva, PG, Nascimento, et al |
Science of the Total Environment |
Review Literature| Revue de littérature |
SR: literature review was performed on PubMed/MEDLINE, Web of Science and Scopus. Higher temperatures and high relative
humidity can have a modest effect on SARS-CoV-2 viability in the environment, as reported in previous studies to this date. However, these studies are experimental, and do not support the fact that the virus has efficiently spread in the tropical regions of
the globe, with other transmission routes such as the contact and droplet ones probably being responsible for the majority of cases reported in these regions, along with other factors such as human mobility patterns and contact rates.
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Daiute, C |
Journal of Humanistic Psychology |
Review Literature| Revue de littérature |
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COVID-19: Intensive Care Acquired Weakness, A Possible Challenge in Patient Recovery? |
David, Oyeneyin Babatunde, Idowu, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
SR |
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Acute chloroquine and hydroxychloroquine toxicity: A review for emergency clinicians |
Della Porta, A, Bornstein, et al |
American Journal of Emergency Medicine |
Review Literature| Revue de littérature |
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Gungor, B, Atici, et al |
American Journal of Emergency Medicine |
Review Literature| Revue de littérature |
SR-MA: searched the electronic databases including Medline, Google Scholar, and Scopus between December 12, 2019 and
April 25, 2020. ncreased levels of D-dimer levels measured on admission are significantly correlated with the severity of COVID-19 pneumonia and may predict mortality in hospitalized patients.
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Stabilizing Cellular Barriers: Raising the Shields Against COVID-19 |
Hanchard, J, Capó-Vélez, et al |
Frontiers in Endocrinology |
Review Literature| Revue de littérature |
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Hobbs, EC, Reid, et al |
Transbound Emerg Dis |
Review Literature| Revue de littérature |
ScR: In domestic settings, viral transmission is self-limiting, however in high density animal environments there can
be sustained between-animal transmission. To date, two potential cases of animal-to-human transmission are being investigated, on infected mink farms. Given the millions of COVID-19 cases worldwide and ongoing potential for further zoonotic and anthroponotic
viral transmission, further research and surveillance activities are needed to definitively determine the role of animals in community transmission of SARS-CoV-2. |
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Kellerborg, K, Brouwer, et al |
Eur J Health Econ |
Review Literature| Revue de littérature |
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Advancing Visual Health Communication Research to Improve Infodemic Response |
King, AJ, Lazard, et al |
Health Commun |
Review Literature| Revue de littérature |
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Are eyes the windows to COVID-19? Systematic review and meta-Analysis |
La Distia Nora, R, Putera, et al |
BMJ Open Ophthalmology |
Review Literature| Revue de littérature |
SR-MA: Literature search was conducted from 4 to 9 June 2020 using three electronic databases: PubMed, ScienceDirect
and Google Scholar. After carefully reviewing the available literature, we found that ocular manifestation can be the first presenting symptom of COVID-19. Eye infection of SARS-CoV-2 could potentially lead to systemic manifestation, although its evidence
needs further investigation. |
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Lemos, GA, Araújo, et al |
Annals of Anatomy |
Review Literature| Revue de littérature |
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COVID-19 in cancer patients: risk, clinical features, and management |
Liu, C, Zhao, et al |
Cancer Biology and Medicine |
Review Literature| Revue de littérature |
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Luan, B, Huynh, et al |
J Proteome Res |
Review Literature| Revue de littérature |
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COVID-19 Effects on Livestock Production: A One Welfare Issue |
Marchant-Forde, J, Boyle, et al |
Frontiers in Veterinary Science |
Review Literature| Revue de littérature |
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Melekhina, ЕV, Muzyka, et al |
Voprosy Prakticheskoi Pediatrii |
Review Literature| Revue de littérature |
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Mendez, J, Villasanti, et al |
American Journal of Dentistry |
Review Literature| Revue de littérature |
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Mendoza, Luis |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
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Michelson, JD |
Clin Orthop Relat Res |
Review Literature| Revue de littérature |
SR |
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COVID-19 AMONG PATIENTS WITH HEPATITIS B OR HEPATITIS C: A SYSTEMATIC
REVIEW |
Mirzaie, Hossein, Vahidi, et al |
medRxiv |
Review Literature| Revue de littérature |
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Moradi, F, Enjezab, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Review Literature| Revue de littérature |
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Murphy, EP, Fenelon, et al |
Clin Orthop Relat Res |
Review Literature| Revue de littérature |
SR: PubMed, MEDLINE, and Embase databases was conducted from database inception to March 2020. Virtual fracture clinics
may provide a means to treat patients remotely, using agreed-upon protocols. They have an important role in the current COVID-19 pandemic, due to the possibility to provide ongoing care in an otherwise challenging setting. |
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Mustafa, MI, Abdelmoneim, et al |
Mediators of inflammation |
Review Literature| Revue de littérature |
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Pal, A, Squitti, et al |
Biol Trace Elem Res |
Review Literature| Revue de littérature |
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Parsons, Nicholas, Outsikas, et al |
medRxiv |
Review Literature| Revue de littérature |
SR: The location of neurological events is consistent with commonly identified neurological symptoms including alterations
in conscious state among COVID-19 patients that require brain imaging. Given the prevalence and severity of these manifestations, clinicians should carefully monitor neurological symptoms within COVID-19 patients and their potential long-term sequelae. |
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Pechmajou, L, Marijon, et al |
Annales de Cardiologie et d'Angeiologie |
Review Literature| Revue de littérature |
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Potential Neurological Manifestations of COVID-19: A Narrative Review |
Pergolizzi, JV, J, et al |
Postgrad Med |
Review Literature| Revue de littérature |
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Raskin, S |
Jornal de pediatria |
Review Literature| Revue de littérature |
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Roberts, L, Hassan, et al |
Business Strategy and the Environment |
Review Literature| Revue de littérature |
SR |
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Rumende, CM, Susanto, et al |
Acta medica Indonesiana |
Review Literature| Revue de littérature |
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Santos-Sánchez, NF, Salas-Coronado, et al |
Medwave |
Review Literature| Revue de littérature |
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33026746; Systemic Medications of Dermatological Importance in COVID-19 |
Schwartz, RA, Sharma, et al |
Journal of drugs in dermatology : JDD |
Review Literature| Revue de littérature |
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Telemedicine and the rural dementia population: A systematic review |
Sekhon, H, Sekhon, et al |
Maturitas |
Review Literature| Revue de littérature |
SR: review was completed using Ovid Medline, Web of Science and ACM Digital Libraries. The testing conditions and the
accessibility of telemedicine yield inconclusive results as to whether telemedicine can improve the management of dementia in geriatric individuals. |
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Setiati, S, Harimurti, et al |
Acta medica Indonesiana |
Review Literature| Revue de littérature |
SR: utilised PubMed, Scopus, ProQuest, Wiley Online Library, ScienceDirect and MedRxiv to search for studies, with
additional hand-searched journals. Age >60 years, hypertension, DM, and coronary heart disease are the risk factors for severe illness of COVID-19. Laboratory test results associated with severe illness are serum LDH 250-500 U/L, LDH >500 U/L, and lymphopenia,
whereas test results associated with mortality are CD3+CD8+ cell count ≤ 75 cell/μl, AKI stage 2 and 3, proteinuria ≥1+, hematuria ≥1+, D-dimer > 1 mg/L, peak serum creatinine > 13.26 μmol/L. |
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Recent advances in ai based automated personalized nutrition system: Future need of healthcare |
Sharma, D, Patel, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Review Literature| Revue de littérature |
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Urology Virtual Education Programs During the COVID-19 Pandemic |
Smigelski, M, Movassaghi, et al |
Curr Urol Rep |
Review Literature| Revue de littérature |
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The role of Chinese medicine in COVID-19 pneumonia: A systematic review and meta-analysis |
Sun, CY, Sun, et al |
American Journal of Emergency Medicine |
Review Literature| Revue de littérature |
SR-MA: Cochrane Central Register of Controlled Trials, PubMed, EMBASE, Chinese National Knowledge Infrastructure, Chinese
Biomedical Database, Wanfang Database and VIP Information Database were seached. ccording to the allocated data, CM has demonstrated clinical efficacy and safety on COVID-19 pneumonia, which need to be confirmed by high quality, multiple-center, large sample
randomized controlled trials. |
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Taj, RM, Mouden, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Review Literature| Revue de littérature |
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Heparin-binding Peptides as Novel Therapies to Stop SARS-CoV-2 Cellular Entry and Infection |
Tavassoly, O, Safavi, et al |
Mol Pharmacol |
Review Literature| Revue de littérature |
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Tizaoui, K, Zidi, et al |
International Journal of Biological Sciences |
Review Literature| Revue de littérature |
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33027461; Ocular manifestations of COVID-19: a literature review |
Torres, BRS, Cunha, et al |
Revista da Associacao Medica Brasileira (1992) |
Review Literature| Revue de littérature |
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Dental risks and precautions during COVID-19 pandemic: A systematic review |
Turkistani, K, Turkistani, et al |
Journal of International Society of Preventive and Community Dentistry |
Review Literature| Revue de littérature |
SR: MEDLINE via PubMed, Cochrane library, Google Scholar and ScienceDirect databases. Dental team need to follow
strict infection control measures and minimize aerosol generation during COVID-19 outbreak. It is the responsibility of dental care workers to keep themselves informed and ensure safety and control transmission within dental facilities.
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Varikasuvu, Seshadri Reddy, Dutt, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
SR-MA: we searched electronic databases like PubMed and Web of Science, research repositories such as LitCovid, CDC,
and WHO along with major journals. Our study showed that higher D-dimer levels provide prognostic information useful for clinicians to early assess COVID-19 patients at risk for disease progression and mortality outcomes. This study, recommending for rapid
assessment of this coagulation marker, also support the ISTH guidelines for accurate D-dimer reporting in COVID-19. |
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A comprehensive study of sars-cov-2: From 2019-ncov to covid-19 outbreak |
Waris, A, Ali, et al |
Microbiology and Biotechnology Letters |
Review Literature| Revue de littérature |
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Wen, J, Cheng, et al |
International Journal of Infectious Diseases |
Review Literature| Revue de littérature |
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Convalescent plasma therapy for pandemics, COVID-19 as example: A mini review |
Yaro, A, Phiri, et al |
Annals of Tropical Medicine and Public Health |
Review Literature| Revue de littérature |
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Yee, J, Kim, et al |
Sci Rep |
Review Literature| Revue de littérature |
SR-MA: searched for qualified studies in PubMed, Embase, and Web of Science. In conclusion, the current review will
serve as an ideal basis for future considerations in the treatment and management of COVID-19 in pregnant women. |
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Clinical characteristics of covid-19 with cardiac injury: a systematic review and meta-analysis |
Zeng, L, Wang, et al |
Epidemiol Infect |
Review Literature| Revue de littérature |
SR-MA: search of literature published between December1, 2019 and May 2, 2020 on the Pubmed, Embase, EuropePMC, medRxiv,
SSRN and CNKI databases. Age, male gender, co-existing diseases and the inflammation index are risk factors for cardiac injury complicated COVID-19 infection. When a patient meets these criteria, cardiac injured biomarkers, such as cardiac troponin and CK-MB,
should be monitored. COVID-19 patients with cardiac injury are usually at higher risk for clinical complications, mechanical ventilation and death, suggesting intensive care may be required for those patients. |
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Zhang, A, Leng, et al |
International Journal of Infectious Diseases |
Review Literature| Revue de littérature |
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Zhao, J, Cui, et al |
Frontiers in Microbiology |
Review Literature| Revue de littérature |
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Reply to: “Can the 2019 Novel Coronavirus Cause Parkinson's Disease?” |
Achbani, A, Sine, et al |
Movement Disorders |
Commentary/Editorial| Commentaire/Éditorial |
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33026745; The Impact of COVID-19 on the Faces of Frontline Healthcare Workers |
Aguilera, SB, De La Pena, et al |
Journal of drugs in dermatology : JDD |
Commentary/Editorial| Commentaire/Éditorial |
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Primed for global coronavirus pandemic: Emerging research and clinical outcome |
Ahamad, S, Branch, et al |
European journal of medicinal chemistry |
Commentary/Editorial| Commentaire/Éditorial |
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Letter to the Editor: The Coronavirus Disease 2019 Impact on Oncofertility Services in Malaysia |
Ahmad, MF, Abu, et al |
J Adolesc Young Adult Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in Children With Cancers and Post-Hematopoietic Stem Cell Transplantation (HSCT) in
Oman |
Al Yazidi, LS, Al Rawas, et al |
J Pediatr Hematol Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Alker, JC, Kenney, et al |
Health affairs (Project Hope) |
Commentary/Editorial| Commentaire/Éditorial |
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Neuraxial anaesthesia in the context of bacterial meningitis and COVID-19 |
Allen, MB, Neal, et al |
British journal of anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Álvarez-López, DI, Espinoza-Molina, et al |
Salud publica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Amirav, I, Newhouse, et al |
Journal of Asthma and Allergy |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 as a Capability Crisis: Using the Capability Framework to Understand Policy Challenges |
Anand, P, Ferrer, et al |
Journal of Human Development and Capabilities |
Commentary/Editorial| Commentaire/Éditorial |
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Starting Out: Beginning Practice as Hospital Social Worker Under COVID-19 |
Anastasi, P |
Australian Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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Challenges for hazardous waste management related to covid-19 pandemic at train station |
Ardiana, N, Suryawan, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Commentary/Editorial| Commentaire/Éditorial |
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Ariawan, I, Jusril, et al |
Acta medica Indonesiana |
Commentary/Editorial| Commentaire/Éditorial |
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Asmar, S, Kulvatunyou, et al |
Journal of Trauma and Acute Care Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Paramedics in pandemics: protecting the mental wellness of those behind enemy lines |
Awais, SB, Martins, et al |
Br J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Bacq, S, Lumpkin, et al |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Badrfam, R, Zandifar, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Digging our own grave: A Marxian consideration of formal education as a destructive enterprise |
Bainbridge, A |
International Review of Education |
Commentary/Editorial| Commentaire/Éditorial |
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Baker, JR, Moshiree, et al |
The American Journal of Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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Understanding and Addressing Latinx COVID-19 Disparities in Washington State |
Baquero, B, Gonzalez, et al |
Health Education and Behavior |
Commentary/Editorial| Commentaire/Éditorial |
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33008700; Risk of self-contamination among healthcare workers in the COVID-19 pandemic |
Barycka, K, Torlinski, et al |
American Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Bauch, ChrisT |
The Lancet Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Beck, DB, Aksentijevich, et al |
Science |
Commentary/Editorial| Commentaire/Éditorial |
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Trotz Covid-19: 15 Ärztinnen und Ärzte erhalten Zertifikat âžPhytotherapie für Ärzte |
Beer, AM |
Zeitschrift fur Phytotherapie |
Commentary/Editorial| Commentaire/Éditorial |
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Bekker, M, Ivankovic, et al |
European journal of public health |
Commentary/Editorial| Commentaire/Éditorial |
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Bell, BP, Romero, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
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Bellan, M, Sainaghi, et al |
Minerva medica |
Commentary/Editorial| Commentaire/Éditorial |
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33023286; A Social Shift: COVID-19 Disparities Prompt Emphasis on Value-Based Care |
Berlin, J |
Texas medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Disinformation and Epidemics: Anticipating the Next Phase of Biowarfare |
Bernard, R, Bowsher, et al |
Health Secur |
Commentary/Editorial| Commentaire/Éditorial |
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Higher Education Amidst COVID-19: Challenges and Silver Lining |
Bhagat, S, Kim, et al |
Information Systems Management |
Commentary/Editorial| Commentaire/Éditorial |
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Modeling U.S. monetary policy during the global financial crisis and lessons for Covid-19 |
Bhar, R, Malliaris, et al |
Journal of Policy Modeling |
Commentary/Editorial| Commentaire/Éditorial |
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Bility, MT, Agarwal, et al |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
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33024331; Plan now to speed vaccine supply for future pandemics |
Bingham, K |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Misuse of SARS-CoV-2 testing in symptomatic health-care staff in the UK – Authors' reply |
Black, JamesRM, Bailey, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Childcare-policy responses in the COVID-19 pandemic: unpacking cross-country variation |
Blum, S, Dobrotić, et al |
European Societies |
Commentary/Editorial| Commentaire/Éditorial |
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Changing the Game: College Dance Training for Well-Being and Resilience Amidst the COVID-19 Crisis |
Bohn, J, Hogue, et al |
Health Promotion Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Boschilia, B, Moraes, et al |
Soccer and Society |
Commentary/Editorial| Commentaire/Éditorial |
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Bradley, VJ |
Intellectual and developmental disabilities |
Commentary/Editorial| Commentaire/Éditorial |
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A short note on coronavirus
disease 2019 (COVID-19) outbreak |
Briggs, DS |
Journal of Public Health and Development |
Commentary/Editorial| Commentaire/Éditorial |
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Editorial overview: Membrane traffic in the time of COVID-19 |
Brodsky, FM, Stow, et al |
Current opinion in cell biology |
Commentary/Editorial| Commentaire/Éditorial |
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Burki, Talha Khan |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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33017239; How COVID-19 Threatens The Safety Net For US Children |
Bylander, J |
Health affairs (Project Hope) |
Commentary/Editorial| Commentaire/Éditorial |
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Challenges in Teaching Palliative Care Module Virtually during COVID-19 Era |
Cassum, S, Mansoor, et al |
Asia-Pacific Journal of Oncology Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Cavicchi, C, Vagnoni, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Diabetes, D-dimer and COVID-19: The possible role of glucose control |
Ceriello, A |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Chakraborty, S |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Addressing opioid overdose deaths: The vision for the HEALing communities study |
Chandler, RK, Villani, et al |
Drug and alcohol dependence |
Commentary/Editorial| Commentaire/Éditorial |
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No one notices the creaky software systems that run the world - Until they fail |
Charette, RN |
IEEE Spectrum |
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Older Black Americans During COVID-19: Race and Age Double Jeopardy |
Chatters, LM, Taylor, et al |
Health Educ Behav |
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Chayama, KL, Ng, et al |
Journal of addiction medicine |
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Chekkal, M, Deba, et al |
Transfusion Clinique et Biologique |
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Chen, DI, Bougie, et al |
Journal of Obstetrics and Gynaecology Canada |
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Chen, I, Bougie, et al |
Journal of Obstetrics and Gynaecology Canada |
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Chen, W, Zhu, et al |
Engineering |
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Chew, Peter |
SSRN- Lancet prepublication |
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Coelho da Maia, ME, Dreer, et al |
Acta Med Port |
Commentary/Editorial| Commentaire/Éditorial |
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33010489; ICU re-organisation to face the first COVID-19 epidemic wave in a tertiary hospital |
Collange, O, Sammour, et al |
Anaesthesia Critical Care and Pain Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Collett, M |
British journal of community nursing |
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The Impact of the COVID-19 Pandemic on Information Systems Management |
Conger, S |
Information Systems Management |
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A gendered lens on COVID-19 employment and social policies in Europe |
Cook, R, Grimshaw, et al |
European Societies |
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Anaesthesia research capacity: time for a rethink in light of the COVID-19 pandemic |
Cook, TM, Kelly, et al |
Anaesthesia |
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Costanzi, A, Mari, et al |
Journal of Trauma and Acute Care Surgery |
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Experts criticise Australia's aged care failings over COVID-19 |
Cousins, Sophie |
The Lancet |
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Crane, A, Matten, et al |
Journal of Management Studies |
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Crooks, CL, Hogg, et al |
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33000610; Covid-19 and cardiac involvement in childhood: state of the art |
Cuppari, C, Ceravolo, et al |
Journal of Biological Regulators and Homeostatic Agents |
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Curtis, M, Bhumbra, et al |
Pediatrics |
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Datta, SS, Mukherjee, et al |
JCO global oncology |
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Personal protective equipment: Suggested best practices for pharmacies during the COVID-19 pandemic |
Dattani, S, Mohr, et al |
Canadian Pharmacists Journal |
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Daughety, MM, Morgan, et al |
Thrombosis research |
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Response to Letter to the Editor: Taste and Smell Dysfunction in COVID-19 Patients |
de Souza, SM, Panichelli, et al |
Annals of Otology, Rhinology and Laryngology |
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de Vincenzo, D |
Documenti Geografici |
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Impacts and challenges to education in academic international medicine during a global pandemic |
De Wulf, A, Bloem, et al |
International Journal of Academic Medicine |
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Laser spectroscopic technique for direct identification of a single virus I: FASTER CARS |
Deckert, V, Deckert-Gaudig, et al |
Proc Natl Acad Sci U S A |
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Hypocalcemia: the quest for the cause of a major biochemical feature of COVID-19 |
di Filippo, L, Formenti, et al |
Endocrine |
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Di Lorenzo, E, Sibillo, et al |
Sustainability (Switzerland) |
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Dicks, AP, Morra, et al |
Journal of chemical education |
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Attempts, Successes, and Failures of Distance Learning in the Time of COVID-19 |
Dietrich, N, Kentheswaran, et al |
Journal of chemical education |
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Dietz, A, Meyer, et al |
Chirurg |
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Drake, C, Yu, et al |
Journal of addiction medicine |
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Response to case comparisons and a new definition of disease-free status |
Duggan, NM, Wilcox, et al |
American Journal of Emergency Medicine |
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33009760; Compassionate Drug Use - Time Arising for a New Law in Bulgaria in the Era of COVID-19 |
Dzhafer, N, Papathanasiou, et al |
Folia medica |
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El Hangouche, AJ, Amekran, et al |
J Sports Med Phys Fitness |
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32897158; If Aviation Were in Control of the COVID-19 Response |
Ephrat, E |
Population Health Management |
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33010994; Pediatric emergency department volumes and throughput during the COVID-19 pandemic |
Even, L, Lipshaw, et al |
American Journal of Emergency Medicine |
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Fard, D, Huguet, et al |
Annales de Cardiologie et d'Angeiologie |
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Fazal, TM |
International Organization |
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33030009; Surgical care during the new coronavirus (Covid-19) pandemic |
Fedorov, AV, Kurganov, et al |
Khirurgiia |
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Fedson, DS |
American Journal of Cardiology |
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33019992; Shortage of anesthetics: Think of inhaled sedation! |
Ferrière, N, Bodenes, et al |
Journal of critical care |
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Managing appendicitis during the COVID-19 pandemic—What do we need to know from the evidence? |
Findlay, JM |
International journal of clinical practice |
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Fransvea, P, Sganga, et al |
Journal of Trauma and Acute Care Surgery |
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Misuse of SARS-CoV-2 testing in symptomatic health-care staff in the UK |
Freudenthal, Bernard |
The Lancet |
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Independent Oncology Practices in the COVID-19 Era-Does US Cancer Care Need a Bailout? |
Frosch, ZAK, Shulman, et al |
JAMA Oncol |
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#StayCentred: Maintaining Personal Education at Centre College during COVID-19 |
Fulfer, KD, Wachter, et al |
Journal of chemical education |
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Furtado, P |
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Gabay, M |
Hospital pharmacy |
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Has COVID-19 Accelerated Digital Transformation? Initial Lessons Learned for Public Administrations |
Gabryelczyk, R |
Information Systems Management |
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Factors Associated with Increased Risk of SARS-CoV-2 Infections in Diabetics |
Gao, J, Gao, et al |
Chinese General Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Adapting a Federal Disaster Medical Assistance Team to Operate during a Pandemic |
Garrett, AL |
Disaster Med Public Health Prep |
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Gavish, R, Krause, et al |
Pediatr Infect Dis J |
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Gentil, P, de Lira, et al |
BioMed research international |
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33030369; Collaboration between a tertiary pain centre and community teams during the pandemic |
George, JM, Xu, et al |
British journal of community nursing |
Commentary/Editorial| Commentaire/Éditorial |
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‘15 Days to Slow the Spread’: Covid-19 and Collective Resilience |
Glynn, MA |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Gómez Balaguer, M, Modrego Pardo, et al |
Endocrinologia, Diabetes y Nutricion |
Commentary/Editorial| Commentaire/Éditorial |
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González-Melado, FJ, Di Pietro, et al |
Enfermedades infecciosas y microbiologia clinica |
Commentary/Editorial| Commentaire/Éditorial |
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Perspective on Proteomics for Virus Detection in Clinical Samples |
Grossegesse, M, Hartkopf, et al |
J Proteome Res |
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Guerrini, CJ, Storch, et al |
Journal of occupational health |
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A Survey of Parents on the Effects of COVID-19 Pandemic on Children Receiving Antileukemic
Therapy |
Gurlek Gokcebay, D, Akcabelen, et al |
J Pediatr Hematol Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Hakim, R, Motreff, et al |
Annales de Cardiologie et d'Angeiologie |
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COVID-19 and biologics in severe asthma: data from the Belgian Severe Asthma Registry |
Hanon, S, Brusselle, et al |
Eur Respir J |
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Hasan, SS |
Anaesthesia, Pain and Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 as a novel etiology of portal vein thrombosis: change in the current management concepts |
Hassan, W, Ramadan, et al |
Infect Dis (Lond) |
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Healy, EF, Blade, et al |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2 risk misclassification explains poor COVID-19 management |
Hernández, Juan Martínez |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Hills, Thomas, Kearns, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Rapid Adaptation of HIV Treatment Programs in Response to COVID-19 - Namibia, 2020 |
Hong, SY, Ashipala, et al |
MMWR Morb Mortal Wkly Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Honore, PM, Barreto Gutierrez, et al |
Crit Care |
Commentary/Editorial| Commentaire/Éditorial |
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Horton, Richard |
The Lancet |
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Iessi, E, Cittadini, et al |
Acta Physiol (Oxf) |
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Imbriaco, G, Monesi, et al |
Journal of Infection Prevention |
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33030322; Viral transmission in COVID-19: the role of the aerosol |
In 't Veen, JCCM, de Hond, et al |
Nederlands tijdschrift voor geneeskunde |
Commentary/Editorial| Commentaire/Éditorial |
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Inzitari, M, Risco, et al |
Journal of Nutrition, Health and Aging |
Commentary/Editorial| Commentaire/Éditorial |
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Ivanova, GE, Melnikova, et al |
Zhurnal nevrologii i psikhiatrii imeni S.S.Korsakova |
Commentary/Editorial| Commentaire/Éditorial |
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Dying in Hospital during COVID-19: Isolation, Despair, and Moral Distress |
John, S, Booth, et al |
Australian Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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Joyce, JA |
James Baldwin Review |
Commentary/Editorial| Commentaire/Éditorial |
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China's mental health support in response to COVID-19: progression, challenges and reflection |
Ju, Y, Zhang, et al |
Global Health |
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Kanitkar, T, Mahalingam, et al |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Managing blood disorders during the Covid-19 pandemic: current pharmacological insights |
Karunakaran, P, Nampoothiri, et al |
Expert Rev Clin Pharmacol |
Commentary/Editorial| Commentaire/Éditorial |
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Protocol for Medicine and Technology for COVID-19 - A Mini Review |
Kashyap, Arjun, GK, et al |
SSRN- Lancet prepublication |
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Katz, C, Cohen, et al |
Child Abuse and Neglect |
Commentary/Editorial| Commentaire/Éditorial |
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Kaufer, AM, Theis, et al |
Pathology |
Commentary/Editorial| Commentaire/Éditorial |
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Kellum, JA, van Till, et al |
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association |
Commentary/Editorial| Commentaire/Éditorial |
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Khanna, N, Klyushnenkova, et al |
Journal of Primary Care and Community Health |
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Killeit, U |
Deutsche Lebensmittel-Rundschau |
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32971100; Managing the Rehabilitation Wave: Rehabilitation Services for COVID-19 Survivors |
Kim, SY, Kumble, et al |
Archives of Physical Medicine and Rehabilitation |
Commentary/Editorial| Commentaire/Éditorial |
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Klein, DE, Libman, et al |
Journal of Stroke and Cerebrovascular Diseases |
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Klimek, L, Huppertz, et al |
World Allergy Organization Journal |
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COVID-19 and the importance of space in entrepreneurship research and policy |
Korsgaard, S, Hunt, et al |
International Small Business Journal: Researching Entrepreneurship |
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The use of antiplatelet agents for arterial thromboprophylaxis in COVID-19 |
Kow, CS, Hasan, et al |
Revista espanola de cardiologia |
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US racial and ethnic data for COVID-19 cases: still missing in action |
Krieger, Nancy, Testa, et al |
The Lancet |
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33024391; COVID-19 pandemic and challenges in pediatric gastroenterology practice |
Kriem, J, Rahhal, et al |
World Journal of Gastroenterology |
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33027854; Notificación empática de muerte remota en el contexto de Covid-19 |
Landa-Ramírez, E, Domínguez-Vieyra, et al |
Salud publica de Mexico |
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Lara, LADS, Marino, et al |
Sexual Medicine |
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Lê, MP, Peiffer-Smadja, et al |
J Antimicrob Chemother |
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Lee, EC, Wada, et al |
Science |
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Nation branding in the COVID-19 era: South Korea’s pandemic public diplomacy |
Lee, ST, Kim, et al |
Place Branding and Public Diplomacy |
Commentary/Editorial| Commentaire/Éditorial |
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Lefèvre, H, Stheneur, et al |
Journal of pain and symptom management |
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Information system security risk management e-learning using fmea in university |
Leonard, A, Anggito, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
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Li, X, Wang, et al |
Engineering |
Commentary/Editorial| Commentaire/Éditorial |
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Lipworth, BJ, Chan, et al |
Lancet Rheumatol |
Commentary/Editorial| Commentaire/Éditorial |
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Llau, JV, Ferrandis, et al |
Medicina Intensiva |
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Emerging from the first COVID-19 wave: Archetyping the new NHS ophthalmic waiting room |
Loh, GK, Bhalla, et al |
BMJ Innovations |
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All that glitters is not gold. The rise of gaming in the COVID-19 pandemic |
López-Cabarcos, MÁ, Ribeiro-Soriano, et al |
Journal of Innovation and Knowledge |
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Lorch, M, Fuchs, et al |
Child and Youth Services |
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Lundstrom, K |
Viruses |
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Randomized Controlled Trials vs Real-World Data in the COVID-19 Era: A False Narrative |
Lyman, GH, Kuderer, et al |
Cancer Invest |
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Value of clinical engagement in the NSW Health response to COVID-19 |
Lyons, N, Cox, et al |
Aust Health Rev |
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Madan, M, Madan, et al |
Archivos de Bronconeumologia |
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Maeckelberghe, E, Schröder-Bäck, et al |
European journal of public health |
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COVID-19 telehealth challenges for patients with schizophrenia and other psychoses |
Maguire, PA, Looi, et al |
Aust N Z J Psychiatry |
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Covid-19: Human challenge studies will see people purposefully infected with virus |
Mahase, E |
Bmj |
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Mahase, E |
Bmj |
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32992042; Reply to “Does asthma affect outcomes of patients with COVID-19 infections?” |
Mahdavinia, M, Codispoti, et al |
Journal of Allergy and Clinical Immunology: In Practice |
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Perceptions of Families of Individuals with Autism Spectrum Disorder during the COVID-19 Crisis |
Manning, J, Billian, et al |
J Autism Dev Disord |
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33027439; Should ethanol be considered a treatment for COVID-19? |
Manning, TJ, Thomas-Richardson, et al |
Revista da Associacao Medica Brasileira (1992) |
Commentary/Editorial| Commentaire/Éditorial |
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Need for psychological support in health professionals before COVID-19 |
Martínez-Pizarro, S |
Psiquiatria Biologica |
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Martins, Tgds |
Acta Med Port |
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Mason, J, West, et al |
Journal of Plastic, Reconstructive and Aesthetic Surgery |
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Impact of COVID-19 pandemic on the management of cutaneous lymphomas |
Mateeva, V, Vassileva, et al |
Clinics in dermatology |
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Protecting Our Own: Equity for Employees as Hospitals Battle COVID-19 |
Maurer, LR, Perez, et al |
Health Equity |
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33027853; Exposición laboral a Covid-19 en personal de salud |
Medina-Guillen, L |
Salud publica de Mexico |
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Medley, GrahamF |
The Lancet |
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Clinical Endpoints for Evaluating Efficacy in COVID-19 Vaccine Trials |
Mehrotra, DV, Janes, et al |
Ann Intern Med |
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Meiksin, A |
Epidemiol Infect |
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Mendenhall, Emily |
The Lancet |
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We Need to Talk about Racism - In All of Its Forms - In Understand COVID-19 Disparities |
Milner, A, Franz, et al |
Health Equity |
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Integrating risk assessment with aviation cybersecurity framework |
Mirchandani, S, Adhikari, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Engaging with local communities: Five key lessons that businesses can learn from universities |
Misra, D, Pinheiro, et al |
Industry and Higher Education |
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Mittal, VA, Firth, et al |
Journal of the American Academy of Child and Adolescent Psychiatry |
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India's Response to the COVID-19 Pandemic: A Frontal Assault on the "Historically Dispossessed" |
Mohan, M, Mishra, et al |
Int J Health Serv |
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The COVID-19 pandemic and its impact on the banking industry - a case of national bank
Ltd |
Mohania, S, Mainrai, et al |
Indian Journal of Finance |
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Strategies for prevention of SARS-CoV-2 infection in a rural Emergency Department |
Monti, M, L’Angiocola, et al |
Hong Kong Journal of Emergency Medicine |
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Why meaning-making matters: the case of the UK Government’s COVID-19 response |
Morgan, M |
American Journal of Cultural Sociology |
Commentary/Editorial| Commentaire/Éditorial |
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The Role of Health Economics and Outcomes Research in Addressing Coronavirus Disease 2019 (COVID-19) |
Mullins, CD, Drummond, et al |
Value in Health |
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Impact of covid 19 lockdown: A move towards sustainable environment |
Munmun, B, Garima, et al |
Research Journal of Chemistry and Environment |
Commentary/Editorial| Commentaire/Éditorial |
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Mitigating a COVID-19 Outbreak Among Major League Baseball Players - United States, 2020 |
Murray, MT, Riggs, et al |
MMWR Morb Mortal Wkly Rep |
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Smartphone ophthalmoscopy: A potential way forward for non-ophthalmology medics in the COVID-19
era |
Nagra, M, Konstantopoulos, et al |
BMJ Innovations |
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Ngamije, J, Yadufashije, et al |
Heliyon |
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Minimize Online Cheating for Online Assessments during COVID-19 Pandemic |
Nguyen, JG, Keuseman, et al |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
|
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Nilson, J, Bugaev, et al |
BMJ open respiratory research |
Commentary/Editorial| Commentaire/Éditorial |
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33002667; Guidelines: Anaesthesia in the context of COVID-19 pandemic |
Niño, MC, De La Hoz, et al |
Anaesthesia Critical Care and Pain Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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33024330; COVID-19 vaccines: how to ensure Africa has access |
Nkengasong, JN, Ndembi, et al |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pneumomediastinum: An Uncommon Complication of COVID-19 Pneumonia |
Nobre Pereira, M, Blanco, et al |
Archivos de Bronconeumologia |
Commentary/Editorial| Commentaire/Éditorial |
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Nugraha, B, Wahyuni, et al |
Acta medica Indonesiana |
Commentary/Editorial| Commentaire/Éditorial |
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Afterword: a critical reckoning with the ‘Asian Century’ in the shadow of the anthropocene |
Oakes, T |
Tourism Geographies |
Commentary/Editorial| Commentaire/Éditorial |
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Oldoni, E, van Gool, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Olivieri, J |
Australian Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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How much of an impact did COVID-19 self-isolation measures have on mental health? |
Omiya, Y, Tokuno, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Library Services during COVID-19 Period: Federal University of Agriculture, Abeokuta Experience |
Onifade, FN |
International Information and Library Review |
Commentary/Editorial| Commentaire/Éditorial |
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Understanding protection from SARS-CoV-2 by studying reinfection |
Overbaugh, J |
Nat Med |
Commentary/Editorial| Commentaire/Éditorial |
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Criminal liability for contagion risks of Covid-19 in healthcare facilities |
Pagani, D |
Archivio Penale |
Commentary/Editorial| Commentaire/Éditorial |
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Pang, DSJ, Pang, et al |
The Canadian veterinary journal = La revue veterinaire canadienne |
Commentary/Editorial| Commentaire/Éditorial |
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Inclusive Biomedical Innovation during the COVID-19 Pandemic |
Pannu, J |
Global Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Papadamou, Kostantinos, Zannettou, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Parigi, TL, Bonifacio, et al |
Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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32618961; Authors' response: Laparoscopy and COVID-19: An off-key song? |
Pata, F, Cuccurullo, et al |
Journal of Trauma and Acute Care Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Pathak, EB |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 pandemic: An
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Journal of Indian Association for Child and Adolescent Mental Health |
Commentary/Editorial| Commentaire/Éditorial |
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33020826; COVID-19 and human rights-why should the public health community be concerned? |
Patterson, D, Paget, et al |
European journal of public health |
Commentary/Editorial| Commentaire/Éditorial |
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The Role of Micronutrients in Support of the Immune Response against Viral Infections |
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Nutrients |
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Peeples, L |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
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33017241; Principles And Policies To Strengthen Child And Adolescent Health And Well-Being |
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33023280; An Unfortunate Legacy: COVID-19 Reveals Long-Standing Health Inequities |
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What life in favelas can teach us about the COVID-19 pandemic and beyond: Lessons from Dona Josefa |
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33020330;
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Acta medica Indonesiana |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and international travel restrictions: the geopolitics of health and tourism |
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Tourism Geographies |
Commentary/Editorial| Commentaire/Éditorial |
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Shahrjerdi, P, Bhaiji, et al |
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Shaw, KS, Karagounis, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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32857015; A Simple Algorithm for Return to Workplace Employer Antibody Testing |
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Population Health Management |
Commentary/Editorial| Commentaire/Éditorial |
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Silva Filho, E, Xavier, et al |
Revista da Associacao Medica Brasileira (1992) |
Commentary/Editorial| Commentaire/Éditorial |
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Commentary/Editorial| Commentaire/Éditorial |
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The Infectious Diseases Act and Resource Allocation during the COVID-19 Pandemic in Bangladesh |
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PMC7361899; Proteinase-activated receptor 1: A target for repurposing in the treatment of COVID-19? |
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Commentary/Editorial| Commentaire/Éditorial |
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Data and cooperation required for Venezuela's refugee crisis during COVID-19 |
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Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Considerations on requirements to recommend herbal preparations |
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COVID-19-associated Multisystem Inflammatory Syndrome in Children Presenting as Acute Pancreatitis |
Stevens, JP, Brownell, et al |
J Pediatr Gastroenterol Nutr |
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Girls and women in the educational system: The curricular challenge |
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Commentary/Editorial| Commentaire/Éditorial |
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A gender-sensitive approach to U.S. crisis communication for COVID-19 and beyond |
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Commentary/Editorial| Commentaire/Éditorial |
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33031087; Air pollution and other risk factors might buffer COVID-19 severity in Mozambique |
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Tale, N, Johari, et al |
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Tan, AL, Farrow, et al |
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Covid 19: Patients have many more complications than flu patients, finds US study |
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Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Taylor, K |
mSphere |
Commentary/Editorial| Commentaire/Éditorial |
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Teekens, T, Giardini, et al |
European Societies |
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The, Lancet |
The Lancet |
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Challenges and recommendations for cancer care in the COVID-19 pandemic |
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Cancer Biology and Medicine |
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33030819; Vacunas contra el SARS-CoV-2: ¿son una realidad para América Latina? |
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Biomedica : revista del Instituto Nacional de Salud |
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Annales de Cardiologie et d'Angeiologie |
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The American Journal of Gastroenterology |
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Are aerosol-generating procedures safer in an airborne infection isolation room or operating room? |
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Covid-19: Factors for
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Ujjan, ID |
Journal of the Liaquat University of Medical and Health Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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32857014; The Essential Role of Technology in the Public Health Battle against COVID-19 |
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Population Health Management |
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Ursin, RL, Shapiro, et al |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives