Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-10-23
Good afternoon,
There are 817 citations in today’s scan. 428 were considered primary research or review literature.
Highlights today include:
CANADA
·
Lemieux, et al.
examine the association between the frequency of news media use during the COVID-19 pandemic and the extent of psychological distress in pregnant women, considering the known deleterious impacts of this distress on fetal development. The more pregnant
women consult the news media during the COVID-19 pandemic, the more prone they are to exhibit psychological distress. The results offer one of the first empirical support for the recommendations of the World Health Organization, the Government of Canada and
psychiatric associations encouraging the population to limit their consultation of the news media during the COVID-19 pandemic.
·
Madhu et al
compared cardiac catheterization procedures for ST-elevation myocardial infarction (STEMI) between January 1 and May 10, 2020 to the same time frame in 2019. Their study concludes that STEMI cases across Ontario have
been substantially affected during the COVID-19 pandemic.
TRANSMISSION
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Harrichandra et al model airborne infection transmission risk in five realistic exposure scenarios using previously estimated outdoor airflow rates for 12 New York City nail
salons. The risk of airborne infection transmission across all salons and all exposure scenarios when not wearing face masks ranged from <0.015% to 99.25%, with an average airborne infection transmission risk of 24.77%. Wearing
face masks reduced airborne infection transmission risk to between <0.01% and 51.96%, depending on the salon, with an average airborne infection transmission risk of 7.30% across all salons. Increased outdoor airflow rates in nail salons were generally strongly
correlated with decreased average airborne infection transmission risk.
·
Vouga et al
enrolled pregnant women at any stage during gestation tested for SARS-CoV-2 infection and recorded maternal, obstetrical and neonatal outcomes. Pregnant women, particularly those with associated comorbidities, seem to be at higher risk of severe complications
of SARS-CoV-2 infection. A positive neonatal SARS-CoV-2 test was observed in 2.9% (n=11/384) of newborns.
·
Tupper and Colijn
use stochastic individual-based simulations to explore the implications of transmission clusters in classrooms and consider heterogeneity in individual variation in infectiousness and effectiveness of a particular environment/activity combination is
for transmitting COVID-19. The modeled analysis finds even small heterogeneities in these variables result in highly variable transmission cluster sizes in the classroom setting. None of the modelled mitigation protocols initiated by a positive test in a symptomatic
individual could effectively prevent large transmission cluster
EPIDEMIOLOGY
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Peng, et al.
investigated the chest CT findings in children with COVID-19, and explored the differences in these findings between symptomatic patients and asymptomatic patients. Symptomatic patients were mainly young children ≤3 years old (54/63, 86%),while asymptomatic
patients were mainly children ≥ 6 years old (51/111, 46%). Fever (41%) and cough (41%) were the most common symptoms. Overall, 119/201 (59%) patients had chest CT findings, and symptomatic patients accounted for 82% (98/119). The lung lesions of most patients
were absorbed and improved in about 9 days.
·
Miyani et al
isolate viruses from wastewater using electropositive NanoCeram column filters from the Great Lakes Water Authority (GLWA) Water Resource Recovery Facility (WRRF) located in southeast Michigan between April 8 and May 26, 2020. Viruses were eluted and
concentrated and SARS-CoV-2 concentrations were quantified with RT-qPCR. SARS-CoV-2 was detected in 100% of samples, and measured concentrations were in the range of 104–105 genomic copies/L.
MOLECULAR EPIDEMIOLOGY
·
Yellapu et al
Evolutionary analysis of 540 genomes spanning 20 different countries/territories was conducted and revealed an increase in the genomic divergence across successive generations. The ancestor of the phylogeny was found to be the isolate from the 2019/2020
Wuhan outbreak. Its transmission was outlined across 20 countries/territories as per genomic similarity. Our results demonstrate faster evolving variations in the genomic structure of SARS-CoV-2 when compared to the isolates from early stages of the pandemic.
Genomic alterations were predominantly located and mapped onto the reported vaccine candidates of structural genes, which are the main targets for vaccine candidates. Potential target regions for vaccines would be ideally chosen from the structural regions
of the genome that lack high variation.
CLINICAL DATA
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Mattos et al
report a case of hematuria in which SARS‐CoV‐2 was detected by RT‐PCR in the urine of an asymptomatic patient.
VACCINE RESEARCH
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Hayashi et al.
In this study, authors designed plasmid DNA vaccine targeting the SARS-CoV-2 Spike glycoprotein (S protein) as pandemic vaccine, and the humoral, cellular, and functional immune responses were characterized to support proceeding
to initial human clinical trials. In conclusion, DNA vaccine targeting the spike glycoprotein of SARS-CoV-2 might be an effective and safe approach to combat the COVID-19 pandemic.
CORONAVIROLOGY
·
Sakanashi, et al.
investigated suitability of saliva as a non-invasively obtained specimen for molecular detection of SARS-CoV-2 RNA in Japanese patients with COVID-19. In total, 28 paired clinical specimens of saliva and nasopharyngeal swabs were collected from 12 patients
at various time points after symptom onset. The saliva and nasopharyngeal swab specimens showed 19 and 15 positive results, respectively. Three convalescent patients presented saliva-positive results, whereas their nasopharyngeal swabs were negative at four
different time points, suggesting that saliva may be superior to nasopharyngeal swabs in terms of obtaining stable assay result of SARS-CoV-2.
PUBLIC HEALTH RESPONSE
·
Simonsen et al.,
examine the occurrence and point prevalence of hand eczema as a consequence of more intensive hand hygiene among Danish children attending daycare during the pandemic. Among 6858 children, 12.1% suffered from hand
eczema before reopening of daycare centers, whereas 38.3% reported hand eczema after the children returned to daycare.
·
Rieger
conducted a survey among 250 subjects recruited at a German university and predominantly university students, we elicit opinions about social distancing, i. e., the necessity to keep away from other people to slow down the speed of the ongoing SARS-CoV-2
epidemics. The good news is that most students are supportive to it. A certain degree of mistrust to media is widespread (around a third of the subjects). To improve positive attitudes to social distancing and thus to improve compliance we recommend therefore
to emphasize relations of persons to elderly people in health communications more.
·
Goldman et al. This study determined
the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19). Less than half of caregivers in this worldwide sample were willing to accept abbreviated COVID-19
vaccine testing.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura
Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Alex Gilbert, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
32999264; Clinical Features and Liver Injury in Patients with COVID-19 in the Japanese Population |
Abe, K, Yamamoto, et al |
Internal medicine (Tokyo, Japan) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study clarified the clinical features and liver injury in Japanese patients with COVID-19. Twenty-two patients
with COVID-19 (median age, 47 years old; men/women, 13/9) were enrolled. Two patients had underlying liver diseases, and two were diagnosed as having COVID-19 without any symptoms. Elevated ALT and GGT levels were found in 12 and 12 patients, respectively,
and liver injury was observed in 15 patients (68.2%). Compared with the patients without liver injury, those with liver injury had a significantly higher fever during the clinical course (median, 37.5°C vs. 38.8°C, p=0.006). A significant correlation was found
between the highest serum liver values and the highest body temperature in each patient. Among the 22 patients, 4 required artificial respiratory support, and 2 died thereafter. Liver injury was not associated with the severity or mortality of COVID-19. |
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Afrin, LB, Weinstock, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This paper describes a novel conjecture explaining how mast cells activation syndrome (MCAS) might cause a propensity for severe acute Covid-19 infection
and chronic post-Covid-19 illnesses. The prevalence of MCAS is similar to in agreement with that of severe cases within the Covid-19-infected population. Much of Covid-19’s hyperinflammation is concordant with manners of inflammation which MC activation can
drive. Drugs with activity against MCs or their mediators have preliminarily been observed to be helpful in Covid-19 patients. None of the authors treated MCAS patients with Covid-19 suffered severe infection, let alone mortality. |
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Agley, Jon, Xiao, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
This was a cross-sectional, online survey (n=660) asked the participants about the believability of five selected COVID-19 narratives, their political
orientation, their religious commitment, and their trust in science (a 21-item scale), along with sociodemographic items. For the full sample, believability of the narratives varied, from a low of 1.94 (SD=1.72) for the 5G narrative to a high of 4.56 (SD=1.64)
for the zoonotic (scientific consensus) narrative. Four distinct belief profiles emerged, with the preponderance (70%) of the sample falling into Profile 1, which believed the scientifically accepted narrative (zoonotic origin) but not the misinformed or conspiratorial
narratives. Other profiles did not disbelieve the zoonotic explanation, but rather believed additional misinformation to varying degrees. Controlling for sociodemographics, political orientation and religious commitment were marginally, and typically non-significantly,
associated with COVID-19 belief profile membership. However, trust in science was a strong, significant predictor of profile membership, with lower trust being substantively associated with belonging to Profiles 2 through 4. |
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Death due to COVID-19 in an Infant with Combined Immunodeficiencies |
Ahanchian, H, Moazzen, et al |
Endocr Metab Immune Disord Drug Targets |
Clinical data| Données cliniques |
Novel coronavirus disease 2019 (COVID-19) has affected millions of people, which led to death especially in older cases with underlying diseases. Meanwhile
pediatric patients with inherited defects of T cell should potentially be prone to viral diseases. Herein, we report an infant with combined immunodeficiency who died because of COVID-19. |
|
Al Mahmoud, RH, Omar, et al |
Journal of Computer Science |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study used Artificial Intelligence (AI) driven methods to predict the parameters, risks and effects of such an epidemic. And introduced two datasets,
each of which consists of 25 country-level factors and covers 137 countries summarizing different domains. COVID-19STC aims to detect the increase of the total cases, whereas COVID-19STD aimed for total death detection. For each data set, three feature selection
algorithms (vis. correlation coefficient, information gain and gain ratio) were applied. Also applied feature selection by the Wrapper methods using four classifiers, namely, NaiveBayes, SMO, J48 and Random Forest. The GDP, GDP Per Capital, E-Government Index
and Smoking Habit factors found to be the main factors for the total cases detection with accuracy of 73% using the J48 classifier. The GDP and E-Government Index are found to be the main factors for total deaths detection with accuracy of 71% using J48 classifier. |
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Alabed, AAA, Elengoe, et al |
Journal of Public Health (Germany) |
Public Health response| Interventions de santé publique |
This study assessed the knowledge, attitude and practice regarding COVID-19 and its transmission, causes and prevention
among people living in Malaysia. Out of 520 respondents, the mean age was 36.9 ± 14.9, between 19 and 67 years with the majority being female. Most respondents had good knowledge, attitude and practice towards COVID-19 with mean ± sd 18.2 ± 1.7, 5.2 ± 1.1
and 4.1 ± 1.4, respectively. In addition, the majority had good knowledge regarding cause, mode of transmission, signs and symptoms, prevention and treatment and quarantine measures after answering 21 questions. |
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Alghounaim, M, Almazeedi, et al |
J Clin Microbiol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
A prospective study was conducted to compare inexpensive and easily sourced 3-dimensionally (3D)-printed polylactic
acid and polyester nasopharyngeal swabs to commercially manufactured swabs for the detection of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Overall concordance between the prototype and control swabs was 80.8% (Cohen's kappa coefficient,
0.61). Most discrepant results were due to prototype-positive control-negative results. When considering all positive results to be true positives, the prototype swab had a higher sensitivity (90.6% versus 80.8%; 95% confidence interval CI], 85.7% to 94.0%
and 74.7% to 85.7%, respectively; P < 0.015). The cost to produce the prototype swab was estimated to be $0.05 per swab. Polylactic acid 3D-printed polyester-tipped swabs were shown to be effective for nasopharyngeal sample collection. |
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Screening of Potential Inhibitors of
Covid-19 with Repurposing Approach Via Molecular Docking |
Alizadehmohajer, Negin, Sadeghi, et al |
Research Square prepub |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study used repurposing approach to previously approved drugs to shorten the dwell-time. Designed and evaluated
a bacterial biosensor expressing a luciferase to assess several available small-molecule; Abl kinase inhibitors, Janus kinase inhibitor, Dipeptidyl peptidase 4 inhibitors, RNA-dependent RNA polymerase inhibitors, and Papin-like Protease inhibitors, using binding
simulation with proteins that might prove to be effective in inhibiting COVID-19 infection. Strong ligand-protein interactions were predicted among some of these drugs, such as Imatinib, Remdesivir, and Telaprevir, and this may render these compounds promising
candidates. Some candidate drugs might be efficient in disease control (directly and indirectly) or in viral proteins attenuation. It is worth to highlight the powerful immunomodulatory role of Abivertinib that inhibits pro-inflammatory cytokine production
that are associated with cytokine release syndrome (CRS) or cytokine storm and progression of COVID-19 infection. |
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Sleep disturbances among physicians during
COVID-19 pandemic |
Alnofaiey, YH, Alshehri, et al |
BMC Res Notes |
Healthcare Response | Réponse des soins de santé |
This study assessed the prevalence and related factors of sleep disturbances among Saudi physicians during COVID-19
pandemic. Prevalence of sleep disorders was 43.9%, doctors in the age group of 31-40 years, associate consultants had a significant higher prevalence of sleep disorders. Medical interns and laboratory/pathology/ |
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Catheter-Directed Thrombolysis of Iliocaval
Thrombosis in Patients With COVID-19 Infection |
Al-Otaibi, M, Iftikhar, et al |
JACC: Case Reports |
Clinical data| Données cliniques |
We present the characteristics and outcomes of the first 2 cases of catheter-directed thrombolysis performed in patients
presenting with coronavirus disease-2019 (COVID-19)-related iliocaval thrombosis. (Level of Difficulty: Beginner.) © 2020 The Authors |
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Ammor, O, Ait Brik, et al |
REC: CardioClinics |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study evaluated the safety of chloroquine or hydroxychloroquine in association with azithromycin as first-line
treatment against COVID-19. A total of 87 patients were treated with the above regimen. On admission, 96.5% of patients were in sinus rhythm, 3 patients presented atrial fibrillation; the baseline heart rate was 83 ± 15 bpm. PR interval was 148 ± 24 ms; QRS
duration was normal (88.6 ± 12.6 ms) with right bundle block in 15 individuals, and left bundle branch block in 2. The mean QTc duration at baseline was 410 ± 31 ms. During treatment, mean QRS increased from 88 ms at baseline to 94 ms on day 2, and to 97 ms
at the end of treatment, with a mean delta QRS (QRS max − initial QRS) at 11 ms. Mean QTc increased from 410 ms to 428 ms on day 2, and 457 ms at the end of treatment, with a mean delta QTc (QTc Max − initial QTc) at 31 ms. Four patients extended their QTc
above 500 ms. A total of 32 patients (36.7%) lengthened their QTc, including 20 women and 12 men (34.5% and 41.4% respectively). This treatment was associated with QTc prolongation in one third of patients, but no major events were noted. |
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Suspected COVID-19-related reticulated purpura of the soles in an infant |
Andina, D, Colmenero, et al |
Pediatr Dermatol |
Clinical data| Données cliniques |
A growing number of skin lesions during the COVID-19 pandemic are being recognized. Acral ischemic lesions identical
to chilblains are most typical in children and young adults. We report an infant girl, aged 1 month and 29 days, with a peculiar reticulated purpuric eruption on her soles, with positive immunohistochemistry for SARS-CoV-2 in the endothelia of dermal blood
vessels. The patient had an excellent outcome without specific therapy. |
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Andreini, D, Conte, et al |
International journal of cardiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study assessed if the presence of high cardiovascular risk, left ventricle systolic dysfunction or elevated BNP
or Troponin are able to independently predict the outcome of patients with known cardiac disease and COVID-19 pneumonia. From March 7th to April 28th, forty consecutive patients with known cardiac disease (chronic coronary artery disease, n=38; atrial fibrillation,
n = 7; valvular disease, n = 13) referred to the emergency department for symptoms of suspected COVID-19, laboratory diagnosis of COVID-19 and typical signs of viral pneumonia at chest CT were enrolled in the study. The only predictor of the composite end-point
(all cause of death + invasive ventilation + thromboembolic event) was the lung involvement % at chest CT (OR: 1.06; 95%CI: 1.01–1.11, P = 0.02). In the multivariate analysis, the lung involvement % at chest CT was the only independent predictor of the composite
end-point (OR: 1.06; 95%CI: 1.01–1.11, P = 0.034). |
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How pets factor into healthcare decisions for COVID-19: A One Health perspective |
Applebaum, JW, Adams, et al |
One Health |
Public Health response| Interventions de santé publique |
The study objective was to understand pet owners' consideration of their pets' welfare when making personal healthcare
decisions specific to COVID-19. Multinomial logistic regression models showed that attachment to pets and socioeconomic resources were important factors in pet owners' hypothetical decisions regarding testing and treatment for COVID-19. Qualitative analysis
of responses to the follow-up question revealed explanations across three themes: (1) the need to find pet accommodation prior to seeking healthcare; (2) pet-related concerns; and, (3) human-related concerns. Pet owners often cited concern for their pets'
welfare as a factor contributing to their decision making; participants' lack of a concrete plan for pet care was most commonly cited as the reason for their delay in seeking healthcare. |
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Arifur Rahman, M, Golzar Hossain, et al |
Journal of Pure and Applied Microbiology |
Epidemiology| Épidémiologie |
This study analyzed the effect of temperature and relative humidity (RH) on the spreading of the SARS-CoV-2 infection.
Among 29 of 31 provinces of China the overall correlation coeffient of the relationship between temperature and viral spread was negative -R(s)] whereas in 15 provinces the correlation was at significant level (p<0.05). Furthermore, there was a significant
negative relationship observed between the SARS-CoV-2 spreading and air temperature throughout the 274 provinces and/or countries of the world. However, there was no significant co-relationship between humidity and COVID-19 spreading either in China or among
countries and/ or various regions of the world. |
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Arun Kishore, RN, Gayathri, et al |
International Journal of Pharmaceutical Research |
Public Health response| Interventions de santé publique |
This survey evaluated the awareness of the self care practices taken by the urban population of Chennai to prevent
COVID 19 infection. 72.44% of the respondents were aware of self care practises to be taken to avoid COVID 19 infection. Majority of the participants were aware of symptoms and precautions to be taken if affected by COVID-19 and also found that both male and
female participants were equally aware of the self care practices(p-value>0.05). |
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33003833; Changes in noise levels in the city of Madrid during COVID-19 lockdown in 2020 |
Asensio, C, Pavón, et al |
The Journal of the Acoustical Society of America |
Public Health response| Interventions de santé publique |
In this article, an analysis has been carried out to describe the reduction in noise pollution that has occurred and
to analyze the changes in the temporal patterns of noise, which are strongly correlated with the adaptation of the population's activity and behavior to the new circumstances. The reduction in the sound level ranged from 4 to 6 dBA for the indicators Ld, Le,
and Ln, and this is connected to a significant variation in the daily time patterns, especially during weekends, when the activity started earlier in the morning and lasted longer at midday, decreasing significantly in the afternoon. |
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A correlation study between weather and atmosphere with COVID-19 pandemic in Islamabad,
Pakistan |
Aslam, B, Khalil, et al |
Spatial Information Research |
Epidemiology| Épidémiologie |
This research study investigated the association between weather and the recent COVID-19 pandemic in Islamabad, Pakistan.
This research also analyzed how different weather situations favor or refrain the spread of the virus and the alterations in the quality of air due to the effects of imposed lockdown in the country. Maximum temperature (r = 0.332; p = 005), and normal temperature
(r = 0.254; p = 0.019) were absolutely and expressively correlated with COVID-19 among the seven weather variables. On the contrary, there was a negative and meaningful association between the precipitation and the COVID-19. Due to the less consumption of
resources, environmental pollution decreased during the quarantine period as people prefer to stay inside. The air quality is indicated by the concentration of NO2 present in the air. The data was extracted for the two consecutive years to have a comparison.
The intensity of NO2 was measured from 1 of February to the 30 of July for both 2019 and 2020. The comparison reveals that there is a substantial decline in the intensity of NO2 in the air, specifically for the month of May when the country was experiencing
a lockdown, thus increase in the quality of the air. |
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Atawneh, SH, Ghaleb, et al |
Journal of Computer Science |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this study, the most accurate time series forecasting model, namely, the Autoregressive Integrated Moving Average
(ARIMA) model is used to forecast the expected cumulative number of confirmed and critical cases in Saudi Arabia for the upcoming months. The main finding is that the number of cumulative confirmed cases is expected to increase at a high rate in the upcoming
two months, while the number of critical cases is forecasted to increase at a smaller rate compared to the total number of cases. To evaluate the performance of the adopted model, different statistical matrices as the R Squared, Mean Squarer Error, Root Mean
Square Error and Mean Absolute Error are used in this research. It is found to be proven from the findings that the proposed model generates an accurate prediction of the expected number of cumulative confirmed and critical cases in the upcoming months. |
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Noninvasive ventilation for acute hypoxemic respiratory failure in patients with
COVID-19 |
Avdeev, SN, Yaroshetskiy, et al |
American Journal of Emergency Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study assessed the outcomes of Noninvasive ventilation (NIV) application in COVID-19 patients with acute hypoxemic
respiratory failure (AHRF). Between April 8 and June 10, 2020, 61 patients were enrolled into the final cohort. NIV was successful in 44 out of 61 patients (72.1%), 17 patients who failed NIV therapy were intubated, and among them 15 died. Overall mortality
rate was 24.6%. Patients who failed NIV were older, and had higher respiratory rate, PaCO2, D-dimer levels before NIV and higher minute ventilation and ventilatory ratio on the 1-st day of NIV. No healthcare workers were infected with SARS-CoV-2 during the
study period. |
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Shorter Androgen Receptor PolyQ Alleles Protect Against Life-Threatening COVID-19 Disease
in Males |
Baldassarri, Margherita, Picchiotti, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
This study developed a synthetic approach to genetic data representation using machine learning methods to investigate
complementary genetic variability in COVID-19 infected patients that might explain disease severity due to rare variants and poly-amino acids repeat polymorphisms. Polymorphisms/rare variants in certain genes, including short polyQ (≤22) of the androgen receptor
( AR ), conferred protection against severe forms of COVID-19. We then demonstrated that testosterone was higher in males with AR long-polyQ (≥23), confirming receptor resistance (p=0.004 Mann-Whitney U test). Finally, long-polyQ (≥23) correlates with increased
inflammation markers (p=0.021) and fibrinogen consumption (p=0.039), confirming the anti-inflammatory role of testosterone. |
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Barboza, GE, Schiamberg, et al |
Child Abuse and Neglect |
Public Health response| Interventions de santé publique |
This study provides unique insights into the spatial and temporal distribution of child abuse and neglect (CAN) in
relation to COVID-19 outcomes and identify areas where CAN has increased or decreased during the pandemic. There was a statistically significant decline in reports of CAN during the COVID-19 pandemic but no significant trends following the implementation
of social distancing measures (e.g. safer at home orders, school closures). Compared to consecutive cold spots, severe housing burden, the number of assets children have at birth, poverty, school absenteeism and labor force participation were significantly
associated with new and intensifying hotspots of CAN during the COVID-19 pandemic. |
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The effect of the severity COVID-19 infection on electrocardiography |
Barman, HA, Atici, et al |
American Journal of Emergency Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to investigate the relationship between electrocardiographic findings and the indicators
of the severity of COVID-19 detected on electrocardiography (ECG). Mean age was 65.2 ± 13.8 years in the severe group and was 57.9 ± 16.0 years in the non-severe group. ST depression (28% vs. 14%), T-wave inversion (29% vs. 16%), ST-T changes (36% vs. 21%),
and the presence of fragmented QRS (fQRS) (17% vs. 7%) were more frequent in the severe group compared to the non-severe group. Multivariate analysis revealed that hypertension (odds ratio OR]: 2.42, 95% confidence interval CI]:1.03–5.67; p = 0.041), the severity
of COVID-19 infection (OR: 1.87, 95%CI: 1.09–2.65; p = 0.026), presence of cardiac injury (OR: 3.32, 95%CI: 1.45–7.60; p = 0.004), and d-dimer (OR: 3.60, 95%CI: 1.29–10.06; p = 0.014) were independent predictors of ST-T changes on ECG. |
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Bartoletti, M, Marconi, et al |
Clinical Microbiology and Infection |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study assessed the efficacy of corticosteroids in patients with coronavirus disease 2019 (COVID-19). Of 1717 patients
with COVID-19 evaluated, 513 were included in the study, and of these, 170 (33%) were treated with corticosteroids. During hospitalization, 166 patients (34%) met the criteria of the primary outcome (60/170, 35% in the corticosteroid group and 106/343, 31%
in the noncorticosteroid group). At multivariable analysis corticosteroid treatment was not associated with lower 30-day mortality rate (adjusted odds ratio, 0.59; 95% confidence interval (CI), 0.20–1.74; p 0.33). After inverse probability of treatment weighting,
corticosteroids were not associated with lower 30-day mortality (average treatment effect, 0.05; 95% CI, −0.02 to 0.09; p 0.12). However, subgroup analysis revealed that in patients with PO2/FiO2 < 200 mm Hg at admission (135 patients, 52 (38%) treated with
corticosteroids), corticosteroid treatment was associated with a lower risk of 30-day mortality (23/52, 44% vs. 45/83, 54%; adjusted odds ratio, 0.20; 95% CI, 0.04–0.90; p 0.036). |
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Bassi, F, Arbia, et al |
Science of the Total Environment |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper proposes to estimate the prevalence of Covid-19 in Italy by reweighting the available official data published
by the Istituto Superiore di Sanità so as to obtain a more representative sample of the Italian population. The authors used post-stratification of the official data, in order to derive the weights necessary for reweighting the sample results, using age and
gender as post-stratification variables, thus obtaining more reliable estimation of prevalence and lethality. Specifically, for Italy, obtained a prevalence of 9%. The proposed methodology represents a reasonable approximation while waiting for more reliable
data obtained with a properly designed national sample survey and that it could be further improved if more data were made available. |
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Bates, A, Ottaway, et al |
Journal of the Intensive Care Society |
Healthcare Response | Réponse des soins de santé |
This study reports concerning levels of anxiety and post-traumatic stress symptomology among intensive care staff during
the Covid-19 crisis, significantly impacting job-related well-being. Seventy-seven per cent reported normal/high level of resilience. Thirty-two staff (35%) reported anxiety of a level at which formal psychological assessment is recommended. Sixteen (14%)
staff members reported symptomology suggestive of post-traumatic stress disorder (PTSD). Multiple regression analysis revealed a significant relationship between job-related well-being, anxiety (p = 0.003) and PTSD (p = 0.005). Nurses were seven times more
likely than doctors to score higher anxiety (OR = 6.8; p = 0.01). Preferred supportive interventions were adequate personal protective equipment, rest facilities and regular breaks. In the subgroup with high anxiety, psychological support was perceived as
significantly more useful, with significant reductions reported for rest facilities and PPE. |
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Batu, ED, Lamot, et al |
Seminars in arthritis and rheumatism |
Healthcare Response | Réponse des soins de santé |
The EMERGE (EMErging RheumatoloGists and rEsearchers) group of PReS (Pediatric Rheumatology European Society) analyzed
how the pandemic has affected pediatric rheumatology practice. From 70 countries, 493 pediatric rheumatologists (80.3% in pediatric rheumatology practice for ≥5 years) responded to the survey. Around 70% disagreed that the pandemic led to reduced prescription
of nonsteroidal anti-inflammatory drugs, conventional synthetic and biologic disease-modifying antirheumatic drugs. Almost half were more likely to taper corticosteroids faster. One-fifth hesitated to switch the major immunosuppressant during a flare. Patients
encountering difficulties obtaining hydroxychloroquine and tocilizumab due to shortages were noted by 192 (38.9%) and 44 (8.9%), respectively. Twenty to 30% indicated that their patients had experienced a flare or delay in diagnosis/intervention due to postponed
appointments.53% mentioned use of phone calls/smartphone applications while 47% shifted towards video consultations for patient care. Respondents indicated an increased number of patients with Kawasaki disease (30%), macrophage activation syndrome (15.6%),
unusual vasculitic rashes (31.4%), and hyperinflammation (33.5%) during the pandemic. |
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Bayramoglu, Z, Canıpek, et al |
Academic Radiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective study reveals the imaging features of COVID-19 in children. Sixty-nine chest radiographs and 37
chest CT examinations of 74 children (36 male; median (interquartile range) age:11 (6.25–15) years, 38 female; median (interquartile range) age: 12 (5.75–16) years) with positive PCR results between March 10 and May 31, 2020 were evaluated. The rate of ground-glass
opacities with or without consolidation (17/37, 45.94%) was higher than consolidation alone (6/37, 16.2%). Feeding vessel sign (16/37, 43.2%), halo sign (9/37, 24.3%), pleural thickening (6/37, 16.2%), interlobular interstitial thickening (5/37, 13.5%), and
lymphadenopathy (3/37, 8.1%) were other imaging findings. |
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Benyounes, N, Van Der Vynckt, et al |
Cardiology Research and Practice |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study explored echocardiography's impact on the management of COVID-19 patients. A total of 56 echocardiographies
in 42 patients with highly suspected or confirmed COVID-19 were included in the final analyses. The median age was 66 (IQR 60.5-74). Echocardiography induced a treatment change in 9 cases (16%). The analyzed clinical data were not associated with any treatment
change induced by echocardiography. D-dimer and Troponin levels were the only biological predictors of the induced treatment change. On echocardiography, higher systolic pulmonary arterial pressure and documented cardiac thrombi were associated with treatment
changes in these patients. |
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Testing Olfactory and Gustatory Dysfunctions among Quarantine COVID-19 Suspects |
Bidkar, V, Mishra, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study investigated the percentage of positive COVID-19 who had associated loss of sensation as detected by psychophysical
testing. The responses in positive and negative individuals presented as age-adjusted odds ratio with 95% CI. Seventy six (9.1%) 95% CI: 7.4%–11.3%] of 832 suspects were tested positive for COVID-19. Paediatric cases of age between 2 and 10 years could not
reply appropriately, hence OD in 134 and GD in 118 could not be tested. Anosmia or hyposmia was present in 62 (81.6%) and ageusia in 64 (84.2%) of the total 76 confirmed cases. The OD and GD dysfunctions were significantly higher among confirmed COVID-19 cases
compared to negative subjects Adj OR (95% CI): Smell 3.22 (1.77–5.88); taste 3.05 (1.61–5.76), p < 0.001]. |
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Results of COVID-Minimal Surgical Pathway During Surge-Phase of COVID-19 Pandemic |
Boffa, DJ, Judson, et al |
Ann Surg |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study evaluated the outcomes of patients treated on the COVID-minimal pathway during a period of surging COVID-19
hospital admissions, to determine the safety of continuing to perform urgent operations during the pandemic. Following implementation, pathway screening processes excluded 7 COVID-19-positive people from interacting with pathway (4 staff and 3 patients).
Overall, 122 patients underwent 125 procedures on pathway, yielding 83 admissions (42 outpatient procedures). The median age was 64 (56-79) and 57% of patients were female. The most common surgical indications were cancer affecting the uterus, genitourinary
tract, colon, lung or head and neck. The median length of admission was 3 days (1-6). Repeat COVID-19 testing performed on 27 patients (all negative), including 9 patients evaluated in an emergency room and 8 readmitted patients. In the post-operative period,
no patient developed a COVID-19 infection. |
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Bonilla-Arcaute, L, Pons-Taracena, et al |
Dermatologia Revista Mexicana |
Clinical data| Données cliniques |
This article is in Spanish. Presents case reports of COVID-19 suspected patients with cutaneous manifestations. |
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COVID-19 associated invasive aspergillosis: data from the UK National Mycology Reference
Laboratory |
Borman, AM, Palmer, et al |
J Clin Microbiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study highlights the challenges in biomarker-driven diagnosis of COVID-19 associated pulmonary aspergillosis (CAPA).
Between 11(th) March and 14(th) July 2020, the UK National Mycology Reference Laboratory received 1267 serum and respiratory samples from 719 critically ill UK patients with COVID-19 and suspected pulmonary aspergillosis. The laboratory also received 46 isolates
of Aspergillus fumigatus from COVID-19 patients (including three that exhibited environmental triazole resistance). Diagnostic tests performed included 1000 (1-3)-β-d-glucan and 516 galactomannan tests on serum samples. For a subset of 61 patients, respiratory
specimens (bronchoalveolar lavages, tracheal aspirates, sputum samples) in addition to serum samples were submitted and subjected to galactomannan testing, Aspergillus-specific PCR and microscopy and culture. The incidence of probable/proven and possible CAPA
in this subset of patients was approximately 5% and 15%, respectively. |
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Brandt, JS, Hill, et al |
American Journal of Obstetrics and Gynecology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to quantify the associations of COVID-19 with adverse maternal and neonatal outcomes in pregnancy
and to characterize the epidemiology and risk factors. We performed a matched case-control study of pregnant patients with confirmed cases who delivered between 16 and 41 weeks’ gestation from March 11 to June 11, 2020. A total of 61 confirmed cases were enrolled
during the study period (mild disease, n=54 88.5%]; severe disease, n=6 9.8%]; critical disease, n=1 1.6%]). The odds of adverse composite maternal outcome were 3.4 times higher among cases than controls (18.0% vs 8.2%; adjusted odds ratio, 3.4; 95% confidence
interval, 1.2–13.4). The odds of adverse composite neonatal outcome were 1.7 times higher in the case group than to the control group (18.0% vs 13.9%; adjusted odds ratio, 1.7; 95% confidence interval, 0.8–4.8). Stratified analyses by disease severity indicated
that the morbidity associated with COVID-19 in pregnancy was largely driven by the severe or critical disease phenotype. Major risk factors for associated morbidity were black and Hispanic race, advanced maternal age, medical comorbidities, and antepartum
admissions related to coronavirus disease 2019. |
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The role of ESG performance during times of financial crisis: Evidence from COVID-19
in China |
Broadstock, DC, Chan, et al |
Finance Research Letters |
Economics | Économie |
We examine the role of ESG performance during market-wide financial crisis, triggered in response to the COVID-19 global
pandemic. The unique circumstances create an inimitable opportunity to question if investors interpret ESG performance as a signal of future stock performance and/or risk mitigation. Using a novel dataset covering China's CSI300 constituents, we show (i) high-ESG
portfolios generally outperform low-ESG portfolios (ii) ESG performance mitigates financial risk during financial crisis and (iii) the role of ESG performance is attenuated in ‘normal’ times, confirming its incremental importance during crisis. We phrase the
results in the context of ESG investment practices. © 2020 Elsevier Inc. |
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Brown, AM, Ardila-Gatas, et al |
Ann Surg |
Healthcare Response | Réponse des soins de santé |
This study aims to show how full-time telemedicine adoption has impacted patient visit volume and attendance in a comprehensive
metabolic and weight loss center. There were a total of 506 visits (162 new patient visits, and 344 follow-ups) in the pre-telehealth period, versus 413 visits (77 new patient visits, and 336 follow-ups) during the post-telehealth period. After telehealth
implementation, new visits for surgeons decreased by 75%. Although follow-up visits decreased by 55.06% for surgeons, there was an increase by 27.36% for advanced practitioners. When surgeons were separated from other practitioners, their follow-up visit rate
decrease by 55.06%, compared to a 16.08% increase for the group of all other practitioners (P < 0.0001). Dietitians experienced higher rates of absenteeism with new patient visits (10.00% vs 31.42%, P = 0.0128), whereas bariatricians experienced a decrease
in follow-up visit absenteeism (33.33% vs 0%, P = 0.0093). |
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COVID-19 financial support to small businesses in Switzerland: evaluation and outlook |
Brülhart, M, Lalive, et al |
Swiss Journal of Economics and Statistics |
Economics | Économie |
We analyse small businesses’ recourse to public support measures during the COVID-19 crisis using a survey of 1011
self-employed workers and small business owners in Switzerland. We find that “objective” measures of lockdown affectedness and economic structure explain fairly well how businesses availed of support measures to cover labour costs. Recourse to government-backed
corona loans, however, appears to be driven to a larger extent by behavioural idiosyncrasies across firms. Specifically, previously indebted businesses took out corona loans more readily than those who had been debt-free before the pandemic. Since uptake is
not well in line with firm fundamentals, we propose making loan repayments contingent on future profits. This will more effectively target and sustain businesses that are in trouble today but would be viable in the absence COVID-19. |
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33007463; Psychological Impact of COVID-19 on ICU Caregivers |
Caillet, A, Coste, et al |
Anaesthesia Critical Care and Pain Medicine |
Public Health response| Interventions de santé publique |
The present study aimed at assessing the psychological impact of COVID-19 on the caregivers at the peak of the “crisis
period”. The incidence of anxiety and depression were 48% and 16%, respectively. PTSD symptoms were present in 27% of respondents. The independent risk factors for developing anxiety syndrome were being assigned in COVID-19 + ICU (OR = 2.081 95% confident
interval (CI), 1.035-4.184)], and not be trained in intensive care medicine, OR = 2.570 95% CI, 1.344-4.901]. The independent risk factors for PTSD are having a history of burn-out (OR = 4.591 95% CI, 1.464-14.397] and not being trained in ICU, (OR = 2.155
95% CI, 1.047-4.440]). |
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Caméléna, F, Moy, et al |
Diagnostic microbiology and infectious disease |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We performed a prospective single-center study in 43 critically ill patients with COVID-19 in which we performed 96
FA-PP tests and cultures of blind bronchoalveolar lavage (BBAL). FA-PP detected 1 or more pathogens in 32% (31/96 of samples), whereas culture methods detected at least 1 pathogen in 35% (34/96 of samples). The most prevalent bacteria detected were Pseudomonas
aeruginosa (n = 14) and Staphylococcus aureus (n = 11) on both FA-PP and culture. The FA-PP results from BBAL in critically ill patients with COVID-19 were consistent with bacterial culture findings for bacteria present in the FA-PP panel, showing sensitivity,
specificity, and positive and negative predictive value of 95%, 99%, 82%, and 100%, respectively. Median turnaround time for FA-PP was 5.5 h, which was significantly shorter than for standard culture (26 h) and antimicrobial susceptibility testing results
(57 h). |
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Campi, R, Tellini, et al |
Urology |
Public Health response| Interventions de santé publique |
This study aimed to explore the perspective of urological patients on the possibility to defer elective surgery due
to the fear of contracting COVID-19. Overall, 332 patients were included (51.5% and 48.5% in the oncology and benign groups, respectively). Of these, 47.9% patients would have deferred the planned intervention (33.3% vs 63.4%; P <.001), while the proportion
of patients who would have preferred to delay surgery for more than 6 months was comparable between the groups (87% vs 80%). These answers were influenced by patient age and American Society of Anesthesiologists score (in the Oncology group) and by the underlying
urological condition (in the benign group). Finally, 182 (54.8%) patients considered the risk of COVID-19 potentially more harmful than the risk of delaying surgery (37% vs 73%; P <.001). This answer was driven by patient age and the underlying disease in
both groups. |
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Genomic Variations in SARS-CoV-2 Strains at the Target Sequences of Nucleic
Acid Amplification Tests |
Cao, Canhui, Yu, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
Herein, we demonstrated genomic variations at the target sequences for the tests and the geographical distribution
of the variations across countries by analyzing the whole-genome sequencing data of SARS-CoV-2 strains from the 2019 Novel Coronavirus Resource (2019nCoVR) database. Among the 21 pairs of primer sequences in regions ORF1ab, S, E, and N, the total length of
primer and probe target sequences was 938bp, with 131(13.97%) variant loci in 2415 (38.96%) isolates. Primer targets in the N region contained the most variations that were distributed among the most isolates, and the E region contained the least. Single nucleotide
polymorphisms were the most frequent variation, with C to T transitions being detected in the most variant loci. G to A transitions and G to C transversions were the most common and had the highest isolate density. Genomic variations at the three mutation
sites N: 28881, N: 28882, and N: 28883 were the most commonly detected, including in 608 SARS-CoV-2 strains from 33 countries, especially in the United Kingdom, Portugal, and Belgium. |
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Coronavirus disease 2019 (COVID-19) in the heart transplant population: a single-centre
experience |
Caraffa, R, Bagozzi, et al |
Eur J Cardiothorac Surg |
Clinical data| Données cliniques |
We report our experience with 6 patients hospitalized in Northern Italy during the outbreak. All patients were symptomatic
and had positive results from a nasopharyngeal swab test for SARS-CoV-2. Of the 6 patients, 5 were hospitalized and 1 remained self-quarantined at home. Two patients died and 3 were discharged home. Two patients were admittted to the intensive care unit .
Immunosuppressive therapy was modified with a median reduction comprising doses that were 50% cyclosporine and 50% mycophenolate. All patients received a medium-dose of corticosteroids as a bolus medication in addition to their therapy. All hospitalized patients
received hydroxychloroquine; 2 patients received ritonavir/lopinavir. Broad-spectrum antibiotics for prophylaxis were administered to all. One patient had an ischaemic stroke and died of sepsis. |
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Carvajal-Miranda, C, Mañas-Viniegra, et al |
Social Sciences |
Public Health response| Interventions de santé publique |
This research analysed the role of the social media platform Weibo and the Internet search browser Baidu, in a government
controlled online media environment, during the COVID-19 pandemic. In order to undertake this study, we applied the use of content and sentiment analysis to the discourse identified through the topics published during the investigation period, which encompassed
15 December 2019 until 15 March 2020. From the findings of this study, we concluded that, during the pre- and post-COVID-19 period, there was an important presence of social and lifestyle topic categories dominating the online discourse, which dramatically
changed in correlation to the increasing spread of the disease. Additionally, there was a marked absence of topics in relation to economic and political information, and there was a notable absence of an official Government "voice" generating topics. |
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Castillo Álvarez, F, López Pérez, et al |
Med Clin (Engl Ed) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A descriptive study has been designed by reviewing the medical records of all patients diagnosed with MS in the autonomous
community of La Rioja, collecting clinical and epidemiological data. The incidence of COVID-19 cases among the population with MS was 27.27/1000 inhabitants, compared to 12.76/1000 inhabitants in La Rioja (OR 2.17; 95% CI 1.12–4.21). Our results show that
patients with MS have experienced a COVID-19 incidence that is more than double that of the general population and this cannot be attributed to having undergone more PCR studies. |
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Castro, JEF, Hernández, et al |
Revista Cubana de Medicina Militar |
Clinical data| Données cliniques |
This is a 49-year-old patient, hypertensive, affected by COVID-19, treated at the Dr. “Joaquín Castillo Duany” Military
Hospital, who during his stay in the intensive care unit, suffered serious complications such as: Acute respiratory distress syndrome, pneumonia associated with mechanical artificial ventilation, and pulmonary thromboembolism. The delay in going to the hospital,
arterial hypertension, and previous treatment with angiotensin-converting enzyme inhibitors, were among the variables present in this patient, which possibly had a negative impact on his evolution. |
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Chen, Gongyu, Fei, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
In this paper, we present a mixed-integer programming model for redesigning routes and bus schedules for the University
of Michigan (UM)'s campus bus system, to prepare for students' return in the 2020 Fall semester. To ensure less than 15-minute travel time for all routes and to enforce social distancing among passengers, we propose a hub-and-spoke design and utilize real
data of student activities to identify hub locations and reduce the number of bus stops used in the new routes. The new bus routes, although using only 50% or even fewer seats in each bus, can still satisfy peak-hour demand in regular semesters at UM. We sample
a variety of scenarios that cover variations of peak demand, social-distancing requirements, broken-down buses or no-shows of drivers, to demonstrate the system resiliency of the new routes and schedules via simulation. Our approach can be generalized to redesign
public transit systems with social distancing requirement during the pandemic, to reduce passengers' infection risk. |
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Chen, IS |
International Journal of Contemporary Hospitality Management |
Public Health response| Interventions de santé publique |
This paper aims to examine whether individuals’ growth need strength influences the impact of home boredom on online
leisure crafting. The respondents’ experience of home boredom had a time-lagged effect on their thriving at home and career self-management via online leisure crafting. Additionally, their growth need strength amplified the positive impact of home boredom
on online leisure crafting |
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Chen, LQ, Burdowski, et al |
Clinical cardiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to assess cardiac function among COVID-19 patients with and without biomarkers of cardiac
injury and to determine the mortality risk associated with reduced cardiac function. This retrospective cohort study analyzed 143 consecutive COVID-19 patients who had an echocardiogram during hospitalization between March 1, 2020 and May 5, 2020. The mean
age was 67 ± 16 years. Cardiac troponin-I was available in 131 patients and an increased value (>0.03 ng/dL) was found in 59 patients (45%). Reduced cardiac function, which included reduced left or right ventricular systolic function, was found in 40 patients
(28%). Reduced cardiac function was found in 18% of patients without troponin-I elevation, 42% with mild troponin increase (0.04-5.00 ng/dL) and 67% with significant troponin increase (>5 ng/dL). Reduced cardiac function was also present in more than half
of the patients on mechanical ventilation or those deceased. The in-hospital mortality of this cohort was 28% (N = 40). Using logistic regression analysis, we found that reduced cardiac function was associated with increased mortality with adjusted odds ratio
(95% confidence interval) of 2.65 (1.18 to 5.96). |
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Chen, S, Si, et al |
Frontiers in Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Here, we report the epidemiological and clinical characteristics of a family cluster with SARS-CoV-2 infection. In
the family cluster, a 32-year-old male (case 1) and a 53-year-old female (case 2, the mother-in-law of case 1) exhibited clinical symptoms of COVID-19, while case 1's 32-year-old wife (case 3) and their 11-month-old daughter (case 4) were both asymptomatic.
Notably, case 4's nasopharyngeal swab samples was negative for nearly 80 days, and her immune system has been boosted for at least 57 days, but the fecal samples have tested positive for 100 days (May 13, 2020), suggesting SARS-CoV-2 may invade enterocytes
and may exist in individuals with low antiviral immunity for a long term. |
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Chen, Y, Ke, et al |
J Med Virol |
Clinical data| Données cliniques Immunology | Immunologie |
A total of 1578 patients admitted into a newly built hospital specialized for COVID-19 treatment in Wuhan, China, were
enrolled. Clinical features and the levels of SARS-CoV-2 IgM and IgG were analyzed. Symptomatic patients produced more antibodies than asymptomatic patients. The patients who had SARS-CoV-2 RNA shedding after developing IgG were more likely to be sicker patients. |
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Cheng, S, Wu, et al |
Respir Res |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aim to identify independent risk factors to serve as prediction markers for critical illness of SARS-CoV-2 infection.
Age older than 60 years, dyspnea, respiratory rate > 24 breaths per min, leukocytosis > 9.5 × 10(9)/L, neutrophilia > 6.3 × 10(9)/L, lymphopenia 3.53, fibrinogen > 4 g/L, d-dimer > 0.55 μg/mL, blood urea nitrogen > 7.1 mM, elevated aspartate transaminase,
elevated alanine aminotransferase, total bilirubin > 21 μM, and Sequential Organ Failure Assessment (SOFA) score ≥ 2 were identified as risk factors for critical illness. LASSO logistic regression identified the best combination of risk factors as SOFA score,
age, dyspnea, and leukocytosis. The Area Under the Receiver-Operator Curve values for the risk factors in predicting critical illness were 0.921 for SOFA score, 0.776 for age, 0.764 for dyspnea, 0.658 for leukocytosis, and 0.960 for the combination of the
four risk factors. |
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Cherif, EK, Vodopivec, et al |
Water (Switzerland) |
Public health interventions*| Interventions de santé publique |
With the aim of determining the COVID-19 pandemic consequences on the Tangier coastal environment, a linear model using
Sentinel 3 water surface temperature (WST) has been tested in several locations. Data from April 2019 and April 2020, before and during the COVID-19 pandemic related emergency status in Morocco, were compared. The results from April 2019 showed high WST values
and consequently, the poorest water quality in the sites closest to the Boukhalef river mouth. On the other hand, the results from April 2020 showed normal WST values and high water quality in the same study area. The study shows the positive impact of the
COVID-19 pandemic consequences on the coastal environment quality in the study area and indicates the importance of decreasing the industrial discharge on the west coast of Tangier. |
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Chew, SY, Lee, et al |
Annals of the Academy of Medicine, Singapore |
Clinical data| Données cliniques |
A case series of COVID-19 patients admitted to our ICU for respiratory failure from 7 February, with data censoring
at 30 June 2020, was performed from a review of medical records. Twenty-two COVID-19 patients were admitted to our ICU for respiratory failure. The median age was 54.5 years (IQR 30-45.5), 72.7% were male and had at least one comorbidity. The Sequential Organ
Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II scores were 2.5 (IQR 1.25-7) and 10 (8.25-12) respectively. Thirteen patients required invasive mechanical ventilation (IMV) and had a median PaO2/FiO2 ratio of 194 mmHg
(IQR 173-213) after intubation. The 28-day survival was 100%, with 2 patients demising subsequently. The overall ICU mortality rate was 9.1% at the time of data censoring. In IMV survivors, length of IMV and ICU stay were 11 days (IQR 9-17.75) and 16 days
(IQR 12-32) respectively. |
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Use of a smartwatch for assessment of the QT interval in outpatients with coronavirus
disease 2019 |
Chinitz, JS, Goyal, et al |
Journal of Innovations in Cardiac Rhythm Management |
Healthcare Response | Réponse des soins de santé |
The coronavirus disease 2019 (COVID-19) pandemic has necessitated rapid implementation of innovative strategies to
manage patients remotely to help reduce the risk of community and nosocomial transmission. This case demonstrates the use of an Apple Watch (Apple, Cupertino, CA, USA) to monitor for arrhythmias and QT prolongation in a patient with COVID-19 during home isolation.
© 2020 Innovations in Cardiac Rhythm Management |
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Chiumello, D, Busana, et al |
Intensive Care Med |
Clinical data| Données cliniques |
The aim of this study was to investigate whether COVID-19-ARDS differs from all-cause ARDS. COVID-19-ARDS is a subset
of ARDS characterized overall by higher compliance and lung gas volume for a given PaO(2)/FiO(2), at least when considered within the timeframe of our study. |
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Online gaming and urban school children during lockdown-a survey |
Chockalingam, S, Gayathri, et al |
International Journal of Pharmaceutical Research |
Public Health response| Interventions de santé publique |
The aim of the study is to assess the time spent on online gaming and gaming motives of school children during lockdown.
From the survey, it was evident that the amount of time spent on online games by adolescents has increased during the lockdown, where 29.70% of the respondents played for 3-6 hours, 17.82% played for 6-10 hours and 4.95% played for more than 10 hours a day
.The primary motive for the majority of the participants(52%) to choose online games (massively multiplayer online games) was to interact with their friends. From the survey it was also evident that both male and female adolescents had the same primary motive
and spent more time on online games(p-value>0.05).It was found that the children preferred to play games of their choice when given the opportunity. From the survey it was evident that both male and female adolescents had the same primary motive of interacting
with their friends by playing massive multiplayer online games and spent more time on online games. Getting engaged with multiplayer online games was the important reason for not giving proper attention towards the online classes conducted by their schools. |
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Chow, KW, Kelly, et al |
JPEN J Parenter Enteral Nutr |
Clinical data| Données cliniques |
We assessed the use of real-time continuous glucose monitoring (rtCGM) data (Dexcom G6) in a 58-year-old male admitted
to the ICU for severe COVID-19 infection, who developed TPN-induced hyperglycemia with markedly elevated total daily insulin requirements as high as 128 units. rtCGM was used to safely titrate insulin infusion and monitor glucose levels. No episodes of hypoglycemia
were observed despite an extremely aggressive insulin regimen. This case demonstrates the potential utility of rtCGM in the critical care setting and highlights its potential to help conserve personal protective equipment and minimize unnecessary staff exposure
in the setting of COVID-19. |
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Chowdhury, JF, Moores, et al |
N Engl J Med |
Clinical data| Données cliniques |
This case report describes a 78-year-old man with hypertension and hyperlipidemia who was brought to the emergency
department 48 hours ago with a 2-day history of shortness of breath and fever (temperature up to 38.5°C). |
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Chowdhury, MA, Shah, et al |
Advances in Fuzzy Systems |
Epidemiology| Épidémiologie |
In this research, an artificial intelligence (AI) system has been adopted to assess the effective role of various environmental
conditions in the spread of COVID-19. Temperature, relative humidity (RH), and UV index (UVI) of some affected countries were considered as input parameters while the total number of infected people is taken as the output variable. After plotting all available
data as linguistic variables, a relationship is established between temperature, RH, UVI, and the number of infected people. From the surface graph, it can be stated that in addition to UVI, temperature and RH have a significant impact on the number of affected
people. The maximum and minimum temperatures as well as other parameters are considered on the basis of mean values. |
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COVID-19 Mortality Risk in Down Syndrome: Results From a Cohort Study Of 8 Million Adults |
Clift, AK, Coupland, et al |
Ann Intern Med |
Epidemiology| Épidémiologie |
This study aimed to evaluate Down syndrome as a risk factor for death from COVID-19 through a comprehensive analysis
of individual-level data in a cohort study of 8.26 million adults (aged >19 years), as part of a wider COVID-19 risk prediction project commissioned by the U.K. government. Adjusted for age and sex, the HR for COVID-19–related death in adults with versus without
Down syndrome was 24.94 (95% CI, 17.08 to 36.44). After adjustment for age, sex, ethnicity, BMI, dementia diagnosis, care home residency, congenital heart disease, and a range of other comorbid conditions and treatments (Table), the HR for COVID-19–related
death was 10.39 (CI, 7.08 to 15.23); for hospitalization, it was 4.94 (CI, 3.63 to 6.73) (Figure). There was no evidence of interactions between Down syndrome and age, sex, or BMI. |
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Conzelmann, C, Groß, et al |
Pediatrics |
Transmission Coronavirology| Coronavirologie |
We here explored the inactivation of SARS-CoV-2 spiked into human milk by holder pasteurization to reduce the risk
of a possible virus transmission while preserving the milk’s beneficial properties. We explored the efficiency of holder pasteurization against SARS-CoV-2 in 5 milk samples and found that infectivity of all 5 tested SARS-CoV-2 isolates is completely eliminated
by this treatment. Thus, despite no infectious virus having been detected in milk so far, holder pasteurization provides safety for the infant and in milk banks, and reassurance for the mother, who might consider discontinuing breastfeeding and substituting
for infant formula milk that lacks many of the human milk’s important components. |
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Cravero, AL, Kim, et al |
Postgrad Med J |
Healthcare Response | Réponse des soins de santé |
This study aimed to determine how self-reported level of exposure to patients with COVID-19 affected the perceived
safety, training and well-being of residents and fellows. Surveys were completed by 1420 trainees (73% residents, 27% fellows), most commonly from the USA (n=670), China (n=150), Saudi Arabia (n=76) and Taiwan (n=75). Trainees who cared for a greater number
of patients with COVID-19 were more likely to report limited access to PPE and COVID-19 testing and more likely to test positive for COVID-19. Compared with trainees who did not take care of patients with COVID-19 , those who took care of 1-30 patients (adjusted
OR AOR] 1.80, 95% CI 1.29 to 2.51), 31-60 patients (AOR 3.30, 95% CI 1.86 to 5.88) and >60 patients (AOR 4.03, 95% CI 2.12 to 7.63) were increasingly more likely to report burnout. Trainees were very concerned about the negative effects on training opportunities
and professional development irrespective of the number of patients with COVID-19 they cared for. |
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Dai, SP, Zhao, et al |
Journal of Nutrition, Health and Aging |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study was supposed to describe the clinical characteristics of elderly patients with COVID-19 infection from Sichuan
province and the effects of comorbidity. Elderly patients with COVID-19 indicated relatively higher proportion of comorbidities, and the most common were atherosclerotic cardiovascular disease (56.5%), hypertension (43.5%) and chronic pulmonary disease (21.7%).
The proportion of severe cases was higher in elderly group than that in non-elderly group (73.9% and 42.2%, respectively, P=0.012). During hospitalization, elderly patients indicated relatively higher proportion of complications, such as shock (21.7%), respiratory
failure (21.7%). The proportion of patients with a decreased number of CD8+ lymphocytes (82.6%) and B lymphocytes (77.8%) in elderly patients was significantly higher than that in non-elderly group (48.9% and 44.8%, respectively). All 3 deaths were elderly
patients with comorbidities and the cell counts of T lymphocyte subsets, B and NK cells of them were significantly decreased at admission. |
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Dai, YJ, Zhang, et al |
International Journal of Biological Sciences |
Clinical data| Données cliniques |
Here we profiled two SARS-CoV-2 infection related genes, the transmembrane serine protease 2 (TMPRSS2) and the interferon-inducible
transmembrane protein 3 (IFITM3), in human tissues and organs. Consistent with the expression and distribution of ACE2, TMPRSS2 was also highly expressed in digestive, urinary and reproductive systems, but low expressed in lung. Notably, the anti-virus protein
IFITM3 also expressed much lower in lung than other tissues, which might be related to the severe lung symptoms of COVID-19. In addition, the low expression of IFITM3 in immune cells suggested that SARS-CoV-2 might attack lymphocytes and induce the cytokine
release syndrome (CRS). Furthermore, cancer patients were considered as more susceptible to SARS-CoV-2 infection. Our data supposed that fourteen types of tumors might have different susceptibility to the virus according to ACE2, TMPRSS2 and IFITM3 expression
patterns. Interestingly the prognosis of six types of cancers including breast carcinoma (BRCA), lung adenocarcinoma (LUAD), uterine corpus endometrial carcinoma (UCEC), renal clear cell carcinoma (KIRC), prostate adenocarcinoma (PRAD), and hepatocellular
carcinoma (LIHC) were closely related to these gene expressions. |
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Danayiyen, A, Kavsur, et al |
Journal of Public Health (Germany) |
Public Health response| Interventions de santé publique |
This cross-sectional study was conducted in the early stages of the outbreak in Turkey. SEM analysis indicates that
fit indices (χ2 = 4.108 df = 2; χ2/df = 2.05; RMSEA = 0.04; CFI = 0.99; GFI = 0.99; PCLOSE = 0.545) were good model fits. The structural analysis indicated that the comprehensibility of information, perceived effects and controllability of the disease, and
social solidarity had a statistically significant direct positive effect on protective behavior (β = 0.133, p < 0.001; β = 0.399, p < 0.001; β = 0.084, p < 0.001; β = 0.171, p < 0.001, respectively). |
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Das, M, Das, et al |
Stochastic Environmental Research and Risk Assessment |
Public health interventions*| Interventions de santé publique |
The present study aims to assess concentration of PM2.5 across 12 cities located in different spatial segments Indo-Gangetic
Plain (IGP). The result showed that there was substantial decrease of PM2.5 concentrations across the cities located in IGP after implementation of lockdown. Before 30 days of lockdown, average PM2.5 across cities was 65.77 µg/m3 that reached to 42.72 µg/m3
during lockdown periods (decreased by 35%). Maximum decrease of PM2.5 concentrations has been documented in Lower Gangetic Plain (LGP) cities (57%) followed by Middle Gangetic Plain (MGP) cities (34%) and Upper Gangetic Plain (UGP) cities (27%) respectively.
Among all the cities of IGP, maximum decrease of PM2.5 concentrations was recorded in Kolkata (64%) (LGP) followed by Muzaffarpur (53%) (MGP), Asansol (51%) (LGP), Patna (43%) (MGP) and Varanasi (33%) (MGP).Therefore, this study has an immense potentiality
to understand the impact of lockdown on a physical region (Ganga River Basin) and it may be also helpful for planners and policy makers to implement effective measures at regional level to control air pollution. |
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Davies, Patrick, Lillie, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques |
This is a multicentre observational study of children (<18 years) admitted to UK PICUs between 1 April and 10 May 2020,
fulfilling the case definition of PIMS-TS. Over the six week study period: 59/78 (76%) children received IVIG, 57/78 (73%) steroids, and 17/78 (22%) a biologic agent. We found no evidence of a difference in response in clinical markers of inflammation between
patients with PIMS-TS who were treated with IVIG, steroids or biologics, compared to those who were not. Despite a progression to near universal treatment with immunomodulators, the proportion of patients with coronary artery abnormalities increased. Guidelines
universally advised or considered the use of IVIG, steroids, and biologics. |
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Delgado-Gallegos, J, Montemayor-Garza, et al |
Int J Environ Res Public Health |
Healthcare Response | Réponse des soins de santé |
Through an adaptation of the original COVID-stress scales, we developed a remote, fast test designed for healthcare
professionals in the northeastern part of Mexico, an important part of the country with economic and cultural ties to the United States. Our results showed four key correlations as highly dependent: work area-xenophobia (p < 0.045), work with COVID patients-traumatic
stress (p < 0.001), total number of COVID patients per day-traumatic stress (p < 0.027), and total number of COVID patients-compulsive checking and reassurance. Overall, we concluded that normal levels of stress have increased (mild-moderate). Additionally,
we determine that the fear of being an asymptomatic patient (potential to spread without knowing) continues being a concern. |
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Deriba, BS, Geleta, et al |
Patient Preference and Adherence |
Public Health response| Interventions de santé publique |
This study aimed to assess patient satisfaction and associated factors among chronic patients who had a follow-up in
North Shoa healthcare facilities. The overall level of patient satisfaction was 44.6%. The presence of sign and direction indicators (AOR=3.26, 95% CI=1.1, 9.92), obtaining some ordered drugs (AOR=3.7, 95% CI=1.1, 12.54), getting alcohol for hand cleaning
(AOR=2.66, 95% CI=1.1,6.65), obtaining sanitizer for hand cleaning (AOR=4.45, 95% CI=1.72,11.52), and maintaining social distancing (AOR=2.63, 95% CI=1.21, 5.70) were factors associated with patient’s satisfaction. |
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NOx Emissions Reduction and Rebound in China Due to the COVID-19 Crisis |
Ding, J, van der A, et al |
Geophysical Research Letters |
Public health interventions*| Interventions de santé publique |
We have analyzed the NOx emission reductions calculated with an inverse algorithm applied to daily NO2 observations
from TROPOMI onboard the Copernicus Sentinel-5P satellite. This method allows the quantification of emission reductions per city and the analysis of emissions of maritime transport and of the energy sector separately. The reductions we found are 20–50% for
cities, about 40% for power plants, and 15–40% for maritime transport depending on the region. The reduction in both emissions and concentrations shows a similar timeline consisting of a sharp reduction (34–50%) around the Spring festival and a slow recovery
from mid-February to mid-March. |
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32721439; Clinical Outcomes of Acute Pancreatitis in Patients With Coronavirus
Disease 2019 |
Dirweesh, A, Li, et al |
Gastroenterology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We report the clinical outcomes of these patients from 7 hospitals in Minnesota during a 4-month period. A retrospective
analysis of all patients managed within the MHealth Fairview System between March 1 and June 30, 2020, was performed for the occurrence of AP. The primary outcome assessed was index admission mortality. Secondary outcomes included organ failure, multiorgan
failure (MOF), persistent organ failure (POF), length of stay, intensive care unit stay, need for mechanical ventilation, and pancreatitis-related outcomes. Patients with AP and COVID-19 had higher Charlson Comorbidity Index and BISAP scores on presentation.
Alcoholic and idiopathic AP were the predominant diagnoses among the COVID-19–negative and –positive cohorts, respectively. Mortality was significantly higher in patients with AP and coexisting COVID-19 . This cohort also showed a significantly higher incidence
of MOF and POF. However, there were no significant differences in AP pattern, incidence of infected necrosis, splanchnic venous thrombosis, or acute endocrine insufficiency between the 2 cohorts. |
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Do, C, Vu, et al |
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Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
As control measures lift, life and businesses start going to open, the coronavirus pandemic continues to grow. In this
research, we propose a Deep Learning model that recognizes COVID-19 cases using X-ray images (DeepCOVID-19). The model would help physicians to be more confident by having a second opinion in assessing patients. An implementation of the model would help countries
where there is shortage of test kits, while X-ray devices are widely available. © 2020 COPYRIGHT SPIE. |
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Dolgushina, NV, Krechetova, et al |
Akusherstvo i Ginekologiya (Russian Federation) |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Aim. To investigate the impact of patient immune status on the severity of COVID-19. Materials and methods. The prospective
study included 63 employees of the V.I. Kulakov NMRC for OG&P of Minzdrav of Russia with confirmed COVID-19. The patients were stratified into three groups based on the disease severity, including asymptomatic (group 1, n=17), mild (group 2, n=29), and moderate
(group 3, n=17) form of COVID-19. On days 3–7 from the onset of the disease, peripheral venous blood samples were collected from the study subjects and tested for serum levels of anti-SARS-CoV-2 IgG antibodies and immune profile by ELISA. After day 20+, testing
for serum levels of anti-SARS-CoV-2 IgG antibodies was repeated using ELISA. Results. Patients who had a higher BMI, blood group A(II), lower leukocyte and lymphocyte counts, higher relative monocyte count, changes in the immune profile in the form of a lower
number of CD3+, CD3+ CD8+, СD19+, CD19+ CD5+, and phagocytic activity of neutrophils, developed more severe forms of COVID-19. They had severe clinical manifestations of the disease, and 100% of them developed antiviral immunity. |
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COVID-19 treatment resource disparities and social disadvantage in New York City |
Douglas, JA, Subica, et al |
Preventive medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The current study accordingly examined racial and ethnic differences in (1) April 2020 COVID-19 total and positive
viral test rates across 177 New York City (NYC) ZIP Code Tabulation Areas (ZCTA); and (2) November 2019–April 2020 licensed and intensive care unit (ICU) hospital bed access across 194 NYC ZCTAs. Pairwise analyses indicated higher COVID-19 total and positive
test rates per 1000 persons in majority Black and Hispanic vs. majority White ZCTAs. Multiple linear regression analyses indicated that higher percentage of Black and Hispanic residents predicted more total COVID-19 tests per 1000 persons. In contrast, majority
Black and Hispanic ZCTAs had fewer licensed and ICU beds, with social disadvantage predicting lower licensed and ICU bed access per 1000 persons. |
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Doyle, AJ, Thomas, et al |
Thrombosis research |
Clinical data| Données cliniques |
It has not yet been established whether the risk of VTE following COVID-19 pneumonia also persists to 90 days. We
conducted an observational study of our previous cohorts with a minimum of 90 days follow-up from their critical care admission at our centres. Our methods have previously been described and approval was obtained from the Research and Development departments
at both Trusts. The composite endpoint was image-proven pulmonary embolism (PE) and deep vein thrombosis (DVT) including catheter-associated thrombi. The index date was admission to critical and censorship data was 17th July 2020. In total, 129 patients with
COVID-19 infection confirmed by polymerase chain reaction on nasopharyngeal swab or bronchoalveolar lavage were included. 24/129 (19%) patients developed 26 VTE events. The estimated cumulative incidence of VTE over a minimum of 90 days following critical
care admission was 18.6%. When segmental/sub-segmental pulmonary embolism was excluded, the cumulative incidence of VTE was 4.1%. There was no statistical difference in Clauss fibrinogen levels at the time of imaging in those with and without VTE. Given
the absence of VTE following discharge, our data does not support the use of extended thromboprophylaxis post-hospitalisation for patients with COVID-19 following critical care admission. |
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Specific re-distribution of SARS-CoV-2 variants in the respiratory system and intestinal
tract |
Du, P, Song, et al |
Clin Infect Dis |
Coronavirology| Coronavirologie |
Here, by using deep sequencing, we identified two distinct SARS-CoV-2 variants in a COVID-19 patient distinguished
by three genetically linked mutations and |
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Immuno-Inflammatory Characteristics in Low Severity COVID-19 Patients with Digestive
Symptoms |
Duan, C, Zhang, et al |
Gastroenterology Research and Practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this article, we describe the immuno-inflammatory characteristics of low severity COVID-19 patients with digestive
symptoms. Methods. Patients with mild symptoms of COVID-19 were split into three groups based on the patients' symptoms. The first group displayed digestive symptoms only, the second group displayed respiratory symptoms only, and the last group displayed both
digestive and respiratory symptoms. Patients were discharged based on negative results of rRT-PCR testing for SARS-CoV-2 from at least two sequential respiratory tract specimens collected ≥24 hours apart. Results. Mild liver damage and activation of the immuno-inflammatory
system were the most common abnormalities observed in patients with mild COVID-19 symptoms but no significant differences were found (P>0.05). Patients with digestive symptoms were more likely to have slightly higher and later peak values of inflammatory cytokines
during the subsequent course of disease (P<0.05). In addition, a significant correlation between IL-2 and TNF level was found in the first group which included patients with digestive symptoms only (P<0.05). |
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Duan, J, Chen, et al |
American Journal of Emergency Medicine |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The use of high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) in patients with COVID-19 is debated. Methods:
This study was performed in four hospitals of China from January to March 2020. We retrospectively enrolled 23 and 13 COVID-19 patients who used HFNC and NIV as first-line therapy, respectively. Results: Among the 23 patients who used HFNC as first-line therapy,
10 experienced HFNC failure and used NIV as rescue therapy. Among the 13 patients who used NIV as first-line therapy, one (8%) used HFNC as rescue therapy due to NIV intolerance. The duration of HFNC + NIV, intubation rate and mortality did not differ between
patients who used HFNC and NIV as first-line therapy |
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COVID-19-related stigma profiles and risk factors among people who are at
high risk of contagion |
Duan, W, Bu, et al |
Social Science and Medicine |
Public Health response| Interventions de santé publique |
Objective: The current study aims to reveal different patterns of perceived courtesy and affiliate stigma among people
who are at high risk of contagion of COVID-19, and to examine the possible risk factors. Method: A sample including 2813 adults who located in Hubei Province, China (female: n = 2,184, 77.64%; male: n = 629, 22.36%; mean age = 37.85 years, SD = 6.61 years,
range = 18–63 years) were employed in the current study, using latent profile analysis for searching stigma profiles. Results: Three profiles of stigma were found: the “Denier” (35.98%), “Confused moderate” (48.13%) and “Perceiver” (15.89%) displaying the
low, moderate and high level of perceived courtesy and affiliate stigma, respectively. Multinomial logistic regression analyses revealed that generally people with a high level of education, perceived threats, anxiety symptoms, and familiarity with quarantined
cases have a high likelihood to be distributed into the “Perceiver”. |
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Elansary, I, Hamdy, et al |
Journal of System and Management Sciences |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this context, deep learning-based architectures can be considered for predicting drug-target interactions accurately.
In this paper, Recurrent Neural Network (RNN) is used to build drug-target interaction prediction model to predict drug-target interactions. Bat Algorithm (BA) is used in this paper to optimize the model parameters of RNN (RNN-BA) and then using the corona
virus as a target. The drug with the best binding affinity will be a potential cure for the virus. The proposed model consists of different four phases; data preparation phase, hyper-parameters optimizing phase, learning phase and fine-tuning for specific
ligand subsets. The used dataset in this paper to train and evaluate the proposed model is selected from a total of 677,044 SMILES. The experimental results of the proposed model showed high level of performance in comparison with the related approaches. |
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Allosteric Inhibition of the SARS-CoV-2 Main Protease: Insights from Mass Spectrometry
Based Assays |
El-Baba, T, Lutomski, et al |
Angewandte Chemie - International Edition |
Coronavirology| Coronavirologie |
Here, we used native mass spectrometry to characterize the functional unit of Mpro. Analysis of the monomer/dimer equilibria
reveals a dissociation constant of Kd=0.14±0.03 μM, indicating MPro has a strong preference to dimerize in solution. We characterized substrate turnover rates by following temporal changes in the enzyme-substrate complexes, and screened small molecules, that
bind distant from the active site, for their ability to modulate activity. These compounds, including one proposed to disrupt the dimer, slow the rate of substrate processing by ≈35 %. This information, together with analysis of the x-ray crystal structures,
provides a starting point for the development of more potent molecules that allosterically regulate MPro activity. |
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Elezi, F, Tafani, et al |
Indian Journal of Psychiatry |
Public Health response| Interventions de santé publique |
This study aims to investigate the impact of these immediate changes on the mental well-being of the population. Methodology:
Respondents (N = 1678) aged 18-60 years were selected through a convenient sampling method. A questionnaire was administered online for 26 days, where respondents reported the time spent daily in the COVID-19 topic and filled in their generalities, the Patient
Health Questionnaire-9 and Generalized Anxiety Disorder-7. Results: Findings suggest a significant negative correlation between age and anxiety scoring and between age and depression scoring, shown also on the ANOVA test for age and anxiety, where younger
populations had higher anxiety levels, as well as age and depression, where older populations had higher levels of depression. Differences on the level of education resulted in a lower score of anxiety and depression on respondents with higher education. Those
who found themselves jobless from the pandemic scored higher on anxiety and depression. |
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The exponentiated power Lomax distribution and its applications |
El-Monsef, M, Sweilam, et al |
Quality and Reliability Engineering International |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, a new extension of Lomax distribution called the exponentiated power Lomax (EPOLO) distribution is proposed.
The proposed model accommodates monotonically increasing, decreasing, and unimodal hazard rates. A full study of the proposed model parameters using four techniques is introduced and a simulation study is performed to examine the performance of the four methods
of estimation for both complete and censored data. EPOLO distribution is utilized to fit the confirmed total deaths of the COVID-19 in Egypt. |
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32979575; National case fatality rates of the COVID-19 pandemic |
Ergönül, Ö, Akyol, et al |
Clinical Microbiology and Infection |
Epidemiology| Épidémiologie |
We aimed to describe the associations between health indicators and the national CFRs of COVID-19. Methods: We identified
for each country health indicators potentially associated with the national CFRs of COVID-19. We extracted data for 18 variables from international administrative data sources for 34 member countries of the Organization for Economic Cooperation and Development
(OECD). We followed the Guideline for Accurate and Transparent Health Estimates Reporting (GATHER). Results: In multivariable analysis, the variables significantly associated with the increased CFRs were percentage of obesity in ages >18 years, tuberculosis
incidence, duration (days) since first death due to COVID-19, and median age. The COVID-19 test rate, hospital bed density, and rural population ratio decreased the CFR. |
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COVID-19 effect on herding behaviour in European capital markets |
Espinosa-Méndez, C, Arias, et al |
Finance Research Letters |
Public Health response| Interventions de santé publique Economics | Économie |
This article investigates whether COVID-19 pandemic had an effect on herding behaviour in Europe. Using a sample from
the stock exchanges of France (Paris), Germany (Frankfurt), Italy (Milan), United Kingdom (London) and Spain (Madrid), over the period from January 03, 2000 to June 19, 2020, we found robust evidence that COVID-19 pandemic increased herding behaviour in the
capital markets of Europe. |
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Faíco-Filho, KS, Carvalho, et al |
Brazilian Journal of Infectious Diseases |
Epidemiology| Épidémiologie |
Out of a total of 466 HCW of Hospital São Paulo with influenza-like illnesses or any clinical suspicion of COVID-19
were tested for COVID-19 by RT-PCR for SARS-CoV-2 169 (36%) turned out positive and were analyzed by type of exposure and hospital occupation. Data of HCW household locations were also obtained. Logistic workers had the highest positivity rate for SARS-CoV-2
(p = 0.002), while nurse technicians had the highest rate among those reporting routine contacts with patients (p = 0.001). Physicians presented the lowest rate of infection, although living in most affected districts (p < 0.001). Policies and adequate training
for all hospital employees may improve prevention of COVID-19 among all health care service categories. |
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Intracranial hemorrhage in critically ill patients hospitalized for COVID-19 |
Fayed, I, Pivazyan, et al |
Journal of Clinical Neuroscience |
Clinical data| Données cliniques |
We report three cases of spontaneous intracranial hemorrhage in patients who were initially hospitalized at our tertiary
care center in Washington, DC with symptoms of COVID-19. |
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Collective Narcissism, In-Group Satisfaction, and Solidarity in the Face of COVID-19 |
Federico, CM, de Zavala, et al |
Social Psychological and Personality Science |
Public Health response| Interventions de santé publique |
The present study explored the antecedents of solidarity amid the COVID-19 pandemic. Given that solidarity during mass
emergencies involves the development of a social identity encompassing those facing a common fate, we examined how national in-group satisfaction (IS, a belief that the national in-group and one’s membership in it are of high value) versus national collective
narcissism (CN, a belief that the national in-group is exceptional and entitled to privileged treatment but not sufficiently recognized by others) predicted solidarity with those affected by the pandemic in Poland. The results of cross-sectional and dynamic
analyses from a panel study on a representative sample of Polish adults indicate that IS predicted greater COVID-19 solidarity, whereas CN predicted reduced COVID-19 solidarity. |
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The psychological impact of COVID-19 on the families of first-line
rescuers |
Feng, Z, Xu, et al |
Indian Journal of Psychiatry |
Public Health response| Interventions de santé publique |
We aim to understand the extent of their psychological distress in this epidemic and whether they have received sufficient
support. Thus targeted to provide support for them and indirectly reduce the concerns of the rescue workers. From February 27 to March 1, 2020, we used the scales of Perceived Stress Scale, 10-items Connor-Davidson Resilience Scale, Generalized Anxiety Disorder-7,
Patient Health Questionnaire-2, and primary care-posttraumatic stress disorder (PTSD) to evaluate the mental health level of the family members of front-line rescue workers online. Results: Among them, 55% of the family members reported sleep problems, 49.0%
of the family members had mild, and above anxiety symptoms, 12.2% of the family members reported clinically significant depression symptoms, and 10.4% of the family members may have PTSD, 8.3% of family members had thoughts of self-injury or suicide. |
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Figueiredo, R, Tavares, et al |
J Perinat Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The purpose of the study was to estimate the SARS-CoV-2 infection rate in our obstetric population admitted for delivery.
Mathods Between 19th March and May 4th, 184 pregnant women were screened for SARS-CoV-2 infection upon admission. Results Eleven women were positive for SARS-CoV-2, corresponding to a global prevalence of 6.0%. Of these, only two reported symptoms at admission.
The prevalence of asymptomatic infection was 4.9%. We report a lower rate of positive cass than other studies. Eighty-two percent of our cases had no symptoms at admission. |
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Finell, E, Vainio, et al |
Int J Environ Res Public Health |
Healthcare Response | Réponse des soins de santé |
We examined the combined effect of perceived risk associated with COVID-19 infection at work and work community identification
on psychosocial well-being (i.e., frequency of stress symptoms) among health care and social sector workers in Finland. Data were collected via an online questionnaire in June 2020 and analyses of covariance were conducted. Perceived COVID-19 infection risk
at work was classified into high, medium and low risk. In total, 41% of participants reported a high risk. After all background variables were included, participants who reported high perceived infection risk and low work community identification reported
stress symptoms more often than those who reported high perceived risk and high identification. Similarly, the former differed significantly from all other comparison groups (medium and low risk, p < 0.001), being the most stressed. We found that perceived
infection risk and work community identification were not related to each other. |
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Firew, T, Sano, et al |
BMJ Open |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Our study sought to assess factors contributing to HCW infection and psychological distress during the COVID-19 pandemic
in the USA. DESIGN: We conducted a cross sectional survey of HCWs (physicians, nurses, emergency medical technicians (EMTs), non-clinical staff) during May 2020. Participants completed a 42-item survey assessing disease transmission risk (clinical role, work
environment, availability of personal protective equipment) and mental health (anxiety, depression and burn-out). OUTCOME: Prevalence of self-reported COVID-19 infection, in addition to burn-out, depression and anxiety symptoms. RESULTS: Twenty-nine per
cent of respondents met the criteria for being a probable case due to reported COVID-19 symptoms or a positive test. HCWs in the emergency department (31.64%) were more likely to contract COVID-19 compared with HCWs in the ICU (23.17%) and inpatient settings
(25.53%). HCWs that contracted COVID-19 also reported higher levels of depressive symptoms, anxiety symptoms and burn-out. |
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Firstenberg, MS, Libby, et al |
International Journal of Critical Illness and Injury Science |
Clinical data| Données cliniques |
We illustrate a case of a previously healthy male, who was supported on ECMO for severe COVID-19 who demonstrated what
appears to be a complete subjective and objective pulmonary recovery within a short time postdischarge. Our case provides some optimisms that critically-ill COVID-19 patients might recover completely and be able to return to functional lives. |
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Fisher, L, Polonsky, et al |
Journal of diabetes and its complications |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
Aims: To describe the effects of the COVID-19 pandemic on adults with T1D or T2D in the U.S. Methods: Participants,
recruited from the Taking Control of Your Diabetes Research Registry, were ≥19 years old and diagnosed with either T1D or T2D for ≥12 months. Participants completed an online survey on a HIPAA-protected platform. Results: About 40% of respondents reported
that all of their diabetes healthcare appointments at the time were cancelled or postponed, 40% reported a switch to telehealth appointments and almost half reported lower overall satisfaction with these visits (compared to pre-pandemic). There were widespread
increases in general and diabetes-related stress and social isolation, and negative effects on disease management. |
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Flesia, L, Monaro, et al |
J Clin Med |
Public Health response| Interventions de santé publique |
In the present study, we assessed the effect of the pandemic on stress levels in N = 2053 Italian adults, and characterized
more vulnerable individuals on the basis of sociodemographic features and stable psychological traits. A set of 18 psycho-social variables, generalized regressions, and predictive machine learning approaches were leveraged. We identified higher levels of perceived
stress in the study sample relative to Italian normative values. Higher levels of distress were found in women, participants with lower income, and participants living with others. Higher rates of emotional stability and self-control, as well as a positive
coping style and internal locus of control, emerged as protective factors. |
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Fong, Siew-Wai, Yeo, et al |
SSRN- Lancet prepublication |
Coronavirology| Coronavirologie Immunology | Immunologie |
Here, RNA-sequencing was performed to elucidate whole blood transcriptomic profiles and identify contrasting immune
signatures between patients infected with wildtype or Δ382 variant of SARS-CoV-2. Interestingly, immune landscape of Δ382 SARS-CoV-2 infected patients featured an increased T cell response, evidenced by enrichment of genes related to T cell functionality that
correlated with up-regulation of T cell-associated cytokines, under-expression of neutrophil activation-associated genes, lowered systemic inflammation and effective antibody response. |
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33015160; Effects of Short-Term Low-Dose Glucocorticoids for Patients with Mild COVID-19 |
Fu, HY, Luo, et al |
BioMed research international |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Objectives: To evaluate the role of short-term low-dose glucocorticoids in mild COVID-19 patients. Methods: We conducted
a retrospective, cross-sectional, single-center study in Kunming, China. A total of 33 mild COVID-19 cases were divided into two treatment groups (with and without glucocorticoids, methylprednisolone, were used in this setting), and the absolute value of peripheral
blood lymphocyte count; CD3+, CD4+, and CD8+ T cell counts; and the time to achieve negative transformation of a nucleic acid pharyngeal swab were recorded. Results: The mean cumulative time for the 50% negative conversion rate of the nucleic acid in the pharyngeal
swab was 17.7 ± 5.1 days and 13.9 ± 5.4 days in the glucocorticoid group and the nonglucocorticoid group, respectively. There was no significant difference between the nonglucocorticoid group and the healthy group for absolute peripheral blood lymphocyte and
CD8+ T cells; moreover, CD3+ T cells and CD4+ T cells were lower in the nonglucocorticoid group than those in the healthy group from the day of admission to the 18th day and returned to normal at the period of 19-21 days. This study found that the use of
short-term, low-dose glucocorticoids does not negatively influence the clinical outcome, without affecting the final clearance of viral nucleic acid in mild COVID-19 patients. |
|
Fu, X, Jiang, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Similar to SARS, COVID-19 has an incubation period. Once a patient recovers, he or she will not be re-infected or infect
others in a short time, so SEIR model is adopted. The data sets released by Johns Hopkins CSSE include globally reported epidemic numbers started from Jan 22nd. The data sets are divided according to different countries and regions. The data set roughly consists
of three parts: daily number of confirmed cases in each country or region, daily number of fatalities in each country or region, and daily number of recovered cases in each country or region. |
|
|
Garcia, LP, Traebert, et al |
Revista Brasileira de Epidemiologia |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Objective: To analyze the association between the transmission potential of SARS-CoV-2 and the decisions made by the
municipal government of Florianópolis (Brazil) regarding social distancing. Methods: We analyzed new cases of COVID-19 identified in Florianópolis residents between February 1 and July 14, 2020, using a nowcasting approach. . Results: A total of 5,374 cases
of COVID-19 and 26 decrees were analyzed. Nine decrees increased social distancing measures, nine maintained them, and eight loosened them. Of the 26 actions, 9 were consonant and 17 dissonant with the tendency indicated by the Rt. Dissonance was observed
in all of the decrees that maintained the distance measures or loosened them. The fastest expansion in the number of new cases and the greatest amount of dissonant decrees was found in the last two months analyzed. Conclusion: There was an important divergence
between municipal measures of social distancing with epidemiological indicators at the time of each political decision. |
|
|
García-Iriepa, C, Hognon, et al |
J Phys Chem Lett |
Coronavirology| Coronavirologie |
Here, by means of a state-of-the-art computational approach, we propose a rational evaluation of the molecular mechanisms
behind the formation of the protein complex. Moreover, the free energy of binding between ACE2 and the active receptor binding domain of the SARS-CoV-2 spike protein is evaluated quantitatively, providing for the first time the thermodynamics of virus-receptor
recognition. Furthermore, the action of different ACE2 ligands is also examined in particular in their capacity to disrupt SARS-CoV-2 recognition, also providing via a free energy profile the quantification of the ligand-induced decreased affinity. These results
improve our knowledge on molecular grounds of the SARS-CoV-2 infection and allow us to suggest rationales that could be useful for the subsequent wise molecular design for the treatment of COVID-19 cases. |
|
|
Molecular docking analysis of selected phytochemicals against SARS-CoV-2 Mpro receptor |
Garg, S, Anand, et al |
Vegetos |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The present study aims to screen 38 bioactive compounds from 5 selected plants viz., Azadirachta indica, Curcuma longa,
Zingiber officinale, Ocimum basilicum and Panax ginseng against SARS-CoV-2. Shortlisted compounds were subjected to molecular docking study with Mpro receptor present in SARS-CoV-2. The study identified that gedunin, epoxyazadiradione, nimbin and ginsenosides
have potential to inhibit Mpro activity. |
|
Gasparini, M, Khan, et al |
Anaesthesia |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We examined the association between acute and chronic kidney disease with clinical outcomes in 372 patients with coronavirus
disease-19 admitted to four regional intensive care units between 10 March 2020 and 31 July 2020. A total of 216 (58%) patients presented with COVID-19 and renal impairment. Acute kidney injury and/or chronic kidney disease was associated with greater in-hospital
mortality compared with patients with preserved renal function . Mortality was greatest in patients with renal transplants. Mortality rates increased in patients with worsening renal injury according to the Kidney Disease. Survivors were less likely to require
renal replacement therapy compared with non-survivors. |
|
|
Georger, F, Dos Santos, et al |
Annales de Cardiologie et d'Angeiologie |
Healthcare Response | Réponse des soins de santé |
The COV IMPACT study is an early assessment survey conducted for 2 weeks in May 2020, of the perception by all hospital
workers of the changes induced in their professional activity by the pandemic. The study was carried out by a survey sent to the hospital staff of Béziers and Montfermeil. The readjusted working conditions were source of increased physical fatigue for 62 %
of the respondents. Moral exhaustion was reported by 36 %. It was related to the stress of contracting the infection (72 %) but above all of transmitting it to relatives (89 %) with a broad perception of a vital risk (41 %). This stress affected all socio-professional
categories (CSP) and was independent of exposure to COVID. |
|
|
Gerell, M, Kardell, et al |
Crime Science |
Public Health response| Interventions de santé publique |
The first major interventions in Sweden were implemented in the end of week 11 (March 12th) in the year 2020, and we
analyze police reported crimes through week 21 (ending May 24th). Descriptive statistics are provided relative to expected levels with 95% confidence intervals for eight crime types. We find that total crime, assaults, pickpocketing and burglary have decreased
significantly, personal robberies and narcotics crime are unchanged. Vandalism possibly increased somewhat but is hard to draw any firm conclusions on. The reductions are fairly small for most crime types, in the 5-20% range, with pickpocketing being the biggest
exception noting a 59% drop relative to expected levels. |
|
|
Gharamti, AmalA, Mei, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The objective of this study was to determine if the Ferritin-to-Procalcitonin ratio (F/P) can be used to differentiate
COVID-19 from bacterial pneumonia. An F/P greater than or equal to 877 increases the likelihood of COVID-19 pneumonia compared to bacterial pneumonia. |
|
|
Gharebaghi, N, Nejadrahim, et al |
BMC Infect Dis |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
The objective of this study was to evaluate the efficacy of intravenous immunoglobulin (IVIg) in patients with severe
COVID-19 infection. The study demonstrated that the administration of IVIg in patients with severe COVID-19 infection who did not respond to initial treatment could improve their clinical outcome and significantly reduce mortality rate. |
|
|
Knowledge, attitude, and practice regarding coronavirus disease-19: Population-based
study in iraq |
Ghazi, HF, Taher, et al |
Open Access Macedonian Journal of Medical Sciences |
Public Health response| Interventions de santé publique |
The aim of this study was to assess knowledge, attitude, and practice (KAP) of Iraqi population toward COVID-19. The
overall knowledge, practice of respondents was good regarding COVID-19. |
|
Ghorbani, Elaheh, Molavian, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique Economics | Économie |
In this study authors propose a model to minimize the economic impact of Covid-19 for businesses and organizations
that have implemented social distancing measures as well as health impact of Covid-19 for their customers and employees. The model could be implemented to other social setups such as sports events, theaters, medical centers, etc. |
|
|
Ghoreishi, A, Arsang-Jang, et al |
Journal of Stroke and Cerebrovascular Diseases |
Healthcare Response | Réponse des soins de santé |
This study examines the changes in stroke epidemiology and care during the COVID-19 pandemic in Zanjan Province, Iran.
The results of this research will contribute to a similar analysis of the larger CASCADE dataset in order to confirm findings at a global scale and improve measures to ensure the best quality of care for stroke patients during the COVID-19 pandemic. |
|
|
Goldman, RD, Marneni, et al |
Clinical therapeutics |
Healthcare Response | Réponse des soins de santé |
This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the
development of vaccines against coronavirus disease 2019 (COVID-19). Less than half of caregivers in this worldwide sample were willing to accept abbreviated COVID-19 vaccine testing. |
|
|
Gollust, SE, Vogel, et al |
Preventive medicine |
Public Health response| Interventions de santé publique |
The objective of this study was to describe public perceptions of disparities in mortality from COVID-19 and examine
correlates of those perceptions. Information about age- and health condition-related disparities in COVID-19 was well known by the U.S. public, while information about social disparities was less recognized and varied along socioeconomic and partisan lines. |
|
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Convalescent plasma therapy in covid-19 patients, in the province of Buenos Aires |
González, SE, Regairaz, et al |
Medicina (Argentina) |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The objectives of this study were to analyze mortality and its independent risk factors, and to assess the occurrence
of a favorable evolution, defined as hospital discharge, or stay at the ward, or transfer from ICU to ward. Severity of illness on admission, age, weight and heart rate were independently associated with evolution. No major adverse effects were recorded. |
|
González, TM, De Mendoza Amat, et al |
Revista Cubana de Medicina Militar |
Healthcare Response | Réponse des soins de santé |
The purpose of the authors is to show the experiences in the preparation and realization of the autopsies in the confrontation
with the COVID-19 in a hospital of attention to patients with suspicion and confirmed in the epidemic. Carrying out autopsies of deceased suspects or confirmed COVID-19 patients, even under special conditions, in the context of the pandemic has provided important
results for the analysis of mortality in the country. |
|
|
González-Valero, G, Zurita-Ortega, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
This study aims to investigate adolescents' self-concept before and during a lockdown period in relation to gender
and type/amount of physical activity or sports. The findings reveal that physical activity was positively correlated to self-concept before and during the COVID-19 lockdown. |
|
|
Gray, N, Calleja, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This analysis uses a modified SIR model to understand the implication and magnitude of misdiagnosis in the context
of ending lockdown measures. The results indicate that increased testing capacity alone will not provide a solution to lockdown measures. The progression of the epidemic and peak infections is shown to depend heavily on test characteristics, test targeting,
and prevalence of the infection. |
|
|
Green, MS, Peer, et al |
PLoS One |
Epidemiology| Épidémiologie |
Authors examined how the age distribution of the cases is responsible for the COVID-19 crude case-fatality rates (CFR)
differences between countries. The age structure of the cases explains much of differences in the crude CFRs between countries and adjusting for age substantially reduces this variation. |
|
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Grima, S, Kizilkaya, et al |
Risk Management and Healthcare Policy |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The purpose of this study is to develop a Pandemic Risk Exposure Measurement (PREM) model to determine the factors
that affect a country’s prospective vulnerability to a pandemic risk exposure also considering the current COVID-19 pandemic. The developed PREM model shows that monitoring of Demographic Features, Country’s Activity Features, Economic Exposure and Societal
Vulnerability can help a country to identify the possible impact of pandemic risk exposure and develop policies, strategies, regulations, etc., to help a country strengthen its capacity to meet the economic, social and in turn healthcare demands due to pandemic
hazards such as COVID-19. |
|
|
The impact of COVID-19 related school shutdown on sleep in adolescents: a natural
experiment |
Gruber, R, Saha, et al |
Sleep medicine |
Public Health response| Interventions de santé publique |
The aim of this study was to describe how the COVID-19 related school shutdown impacted the sleep behaviors of typically
developing adolescents. This strategy offers a practical means to reduce school density and the number of interactions between students which are needed to reduce the potential transmission of COVID-19 in schools, while improving adolescents sleep health. |
|
Guan, X, Guan, et al |
Chinese Journal of Endocrinology and Metabolism |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to investigate the correlation between concomitant diabetes mellitus and clinical features
in patients with COVID-19. Prolonged duration of positive virus-PCR result and average days of hospitalization in patients with COVID-19 may be associated with diabetes mellitus. |
|
|
Extremely wicked, shockingly evil and undoubtedly COVID-19: the silent
serial killer |
Guha, Anasuya, Plzak, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
Authors in Czech Republic designed a national survey to address the significant personal, professional, financial and
economic recession globally due to COVID-19. With the lack of drastic measures in improving the support system for healthcare workers, the healthcare systems will fail quickly. Adequate support should be made mandatory by health authorities. |
|
The mncp-spi score predicting risk of severe covid-19 among mild-pneumonia patients on
admission |
Guo, L, Xiong, et al |
Infection and Drug Resistance |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to predict the risk of developing severe pneumonia among mild novel coronavirus pneumonia
(mNCP) patients on admission. Authors designed a clinical predictive tool for risk of severe pneumonia among mNCP patients to provided guidance for medicines. |
|
33000117; Two Cases of Inadvertent Dental Aerosol Exposure to COVID-19
Patients |
Guo, W, Chan, et al |
Annals of the Academy of Medicine, Singapore |
Transmission Clinical data| Données cliniques |
In this letter to the editor, authors discuss the cases of two inadvertent Dental Aerosol Exposure to COVID-19 Patients.
Authors postulate that the |
|
Hadad, Z, Bartram, et al |
Ugeskrift for laeger |
Clinical data| Données cliniques |
Article in Danish. Pulmonary etbollus in a patient with COVID-19. Authors discuss the incidence of pulmonary etbollus
(PE) in patients with COVID-19. They would like to draw attention to this study by clinically suspecting PE, which may not have been verified by CT angiography. |
|
|
Awareness level of doctors regarding corona virus infection disease
(COVID-19) |
Haider, I, Badshah, et al |
Journal of Medical Sciences (Peshawar) |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to assess the awareness level of medical doctors regarding COVID-19 in Pakistan. Doctor’s
community is aware of different aspects of COVID-19 including epidemiology, clinical manifestations, diagnostics, complications and preventive measures effective against COVID-19. |
|
Haldar, R, Kannaujia, et al |
Indian Journal of Anaesthesia |
Healthcare Response | Réponse des soins de santé |
An electronic survey to assess the effect of the measures taken by hospitals due to COVID-19 on anesthesiology postgraduate
teaching was undertaken using a validated questionnaire. Teaching and training schedules of anesthesiology postgraduate students have undergone major modifications following the COVID 19 pandemic. |
|
|
Hao, Y, Li, et al |
Journal of Inflammation Research |
Clinical data| Données cliniques |
Authors conducted this retrospective study to clarify the clinical features and possible risk predictors of “re-positive”
in discharged COVID-19 patients. The results indicated that albumin/globulin ratio (AGR) may potentially have a predictive effect in “re-positive” discharged COVID-19 patients. Further definitive largescale clinical studies are feasible and needed. |
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When to Relax Social Distancing Measures? An ARIMA Based Forecasting Study |
Hariharan, Ramya |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
The spread of the novel coronavirus across various countries is wide and rapid. The number of confirmed cases and the
reproduction number are some of the epidemiological parameters utilized in scientific studies for the analysis and prediction of the viral transmission. The positive rate, an indicator on the extent of testing the population, aids in understanding the severity
of the infection in a given geographic location. The positive rate for selected countries has been considered in this study to construct ARIMA based statistical models. The goodness of fit of the models are verified by the investigation of residuals, Box-Luang
test and the forecast error values. The positive rates forecasted by the ARIMA models are utilized to investigate the scope for implementation of relaxations in social distancing measures in some countries and the necessity to tighten the rules further in
some other countries. |
|
A Neurochaos Learning Architecture for Genome Classification |
Harikrishnan, NB, P |
arXiv |
Coronavirology| Coronavirologie |
Authors propose a Neurochaos Learning (NL) architecture, where the neurons used to extract features from data are 1D
chaotic maps. They consider the problem of classification of genome sequences of SARS-CoV-2 from other coronaviruses (SARS-CoV-1, MERS-CoV and others). |
|
An estimation of airborne SARS-CoV-2 infection transmission risk in New York City
nail salons |
Harrichandra, A, Ierardi, et al |
Toxicol Ind Health |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
Authors sought to model airborne infection transmission risk assuming five realistic exposure scenarios using previously
estimated outdoor airflow rates for 12 New York City nail salons. The results of this study indicate that increased outdoor airflow rates and the use of face masks by both employees and customers could substantially reduce SARS-CoV-2 transmission in New York
City nail salons. |
|
Antiviral Nanostructured Surfaces Reduce the Viability of SARS-CoV-2 |
Hasan, J, Pyke, et al |
ACS Biomaterials Science and Engineering |
Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
In this letter, we report the ability of the nanostructured aluminum Al 6063 alloy surfaces to inactivate the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Such nanostructured surfaces have the potential to be used in healthcare environment such as hospitals and public spaces to reduce the surface transmission of SARS-CoV-2 and combat COVID-19. |
|
Hayashi, Hiroki, Sun, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins |
In this study, authors designed plasmid DNA vaccine targeting the SARS-CoV-2 Spike glycoprotein (S protein) as pandemic
vaccine, and the humoral, cellular, and functional immune responses were characterized to support proceeding to initial human clinical trials. In conclusion, DNA vaccine targeting the spike glycoprotein of SARS-CoV-2 might be an effective and safe approach
to combat the COVID-19 pandemic. |
|
|
He, Y, Dong, et al |
Disaster Med Public Health Prep |
Clinical data| Données cliniques |
In this paper, authors look at the clinical characteristics, possible causes, pathogenesis, and infectivity of re-detectable
positive patients and provide up-to-date information to public health policy planners and clinicians. It can't be completely ruled out that the re-detectable positive patients are infectious. |
|
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Diagnostic Value of Lung Ultrasonography in Children with COVID-19 |
Hizal, M, Aykac, et al |
Pediatr Pulmonol |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The objective of this study was to determine the diagnostic value of lung ultrasound (LUS) in the evaluation of children
with COVID-19. LUS might be a useful tool in the diagnostic steps of children with COVID-19. |
|
Holst, H, Fessler, et al |
European Societies |
Public Health response| Interventions de santé publique Economics | Économie |
This study analyses inequalities in how German employees experience corona-related health and economic risks at the
workplace. Perceived health risks are highest for the classes based on the interpersonal work logic, whereas the independent classes and the technical classes experience higher economic risks. |
|
|
Hourdel, V, Kwasiborski, et al |
Frontiers in Microbiology |
Coronavirology| Coronavirologie |
Authors implemented an amplicon-based sequencing approach combined with easily deployable next-generation sequencers,
the small and hand-held MinION sequencer and the latest most compact Illumina sequencer, the iSeq100TM system. The results highlighted the great potential of the amplicon-based approach to obtain consensus genomes of SARS-CoV-2 from clinical samples in just
a few hours. |
|
|
Hoyos Mejía, L, Romero Román, et al |
Eur J Cardiothorac Surg |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Authors reviewed the incidence of coronavirus disease 2019 cases and the postoperative outcomes of patients who had
thoracic surgery during the beginning and at the highest point of transmission in our community. The results indicate that, in properly selected cases, with short preoperative in-hospital stays, strict isolation and infection control protocols, managed by
a dedicated multidisciplinary team, a surgical procedure could be performed with a relatively low risk for the patient. |
|
|
Lower Circulating Interferon-Gamma Is a Risk Factor for Lung Fibrosis in COVID-19
Patients |
Hu, ZJ, Xu, et al |
Frontiers in Immunology |
Clinical data| Données cliniques |
Authors investigated the effect of inflammatory molecules to identify any marker that is related to lung fibrosis in
COVID-19. In conclusion, the data indicate that decreased circulating IFN-γ is a risk factor of lung fibrosis in COVID-19. |
|
Huang, Q, Hu, et al |
European review for medical and pharmacological sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aim to describe the characteristics, screening methods, and outcomes of cancer patients with asymptomatic COVID-19
infection and to further explore anti-tumour treatment for this population. A total of 16 cancer patients with asymptomatic COVID-19 infection were confirmed. The most common cancer type was breast cancer. The blood cell counts of most patients were in the
normal range. Lymphocytes of 100% of asymptomatic carriers were in the normal range. Thirteen (81.3%) patients were positive for virus-specific IgM antibodies, and three (18.8%) were positive by PCR; only one (6.3%) patient showed novel coronavirus pneumonia
features on CT. Three (18.3%) patients died, and the cause of death was considered malignancy caused by delaying anti-tumour treatment. This result indicates that the host immunity of asymptomatic carriers is not significantly disrupted by COVID-19. Single
PCR detection is not sufficient to screen among asymptomatic individuals, and a combination of PCR tests, serological tests and CT is of great importance. |
|
|
Ibarra-Armenta, Cristina |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Through an Ordinal Probit, Cross Section and Panel data models for 71 countries, it is shown that the nations applying
more tests per million inhabitants are also those reporting more cases and deaths, yet greater testing helped to reduce CFR; while, health infrastructure and population health indicators could not be confirmed as drivers for CFR. The Stringency Index showed
a negative correlation with the number of deaths. Our main finding is that, the pandemic concentration on developed nations is highly related with their ability and resources for tracking the pandemic. Three additional conclusions are drawn: first, the true
CFR and its drivers at national levels cannot be estimated without increasing the number of tests per million inhabitants; second, there is an under-identification of cases and/or deaths and the countries applying more tests, are most clearly identifying the
reality of the pandemic, while countries with less cases, are actually still walking in the dark; third lockdown measures have been effective at reducing the number of deaths. |
|
|
Analysis of a Covid-19 model: Optimal control, stability and simulations |
İğret Araz, S |
Alexandria Engineering Journal |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this paper, we analyzed a mathematical model for the spread of COVID-19, we first start with stability analysis,
present the optimal control for the system. The model was extended to the concept of non-local operators for each case, we presented the positiveness of the system solutions. We presented numerical solutions are presented for different scenarios. |
|
Imaeda, T, Hattori, et al |
American Journal of Emergency Medicine |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We report the first case of a COVID-19 patient on veno-venous extracorporeal membrane oxygenation (V-V ECMO), transferred
to our ECMO center by helicopter. A 45-year-old man with rheumatoid arthritis history, treated with immunosuppressants, presented with fever and sore throat. He was diagnosed with COVID-19 following a positive severe acute respiratory syndrome coronavirus
2 polymerase chain reaction test result and was subsequently prescribed favipiravir. However, his respiratory failure progressively worsened. On day 10 of hospitalization at the previous hospital, he was intubated, and we received a request for ECMO transport
on the next day. The ECMO team, who wore personal protective equipment (N95 respirators, gloves, gowns, and face shields), initiated V-V ECMO in the referring hospital and safely transported the patient by helicopter. The flight time was 7 min. He was admitted
to the intensive care unit of our hospital and received tocilizumab. He was discharged on hospital day 31 with no significant sequelae. |
|
|
Scarlett letter: A study based on experience of stigma by COVID-19 patients in quarantine |
Imran, N, Afzal, et al |
Pakistan Journal of Medical Sciences |
Public Health response| Interventions de santé publique |
The aim of the current study was to explore the stigma experienced by hospitalized patients with COVID-19 illness in
Lahore, Pakistan. One hundred and fourteen patients were interviewed with 53.5% being males. Widespread experience of stigma was reported by patients particularly for concerns about public attitudes & disclosure. Main themes which emerged from the qualitative
responses were social stigma and rejection, humiliating behavior of others, breach of confidentiality, loss of trust/ respect, and impact of COVID-19 diagnosis on their business. |
|
Detection of COVID-19 through the analysis of vocal fold oscillations |
Ismail, Mahmoud Al, Deshmukh, et al |
arXiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Since most symptomatic cases of COVID-19 present with moderate to severe impairment of respiratory functions, we hypothesize
that signatures of COVID-19 may be observable by examining the vibrations of the vocal folds. Our goal is to validate this hypothesis, and to quantitatively characterize the changes observed to enable the detection of COVID-19 from voice. For this, we use
a dynamical system model for the oscillation of the vocal folds, and solve it using our recently developed ADLES algorithm to yield vocal fold oscillation patterns directly from recorded speech. Experimental results on a clinically curated dataset of COVID-19
positive and negative subjects reveal characteristic patterns of vocal fold oscillations that are correlated with COVID-19. We show that these are prominent and discriminative enough that even simple classifiers such as logistic regression yields high detection
accuracies using just the recordings of isolated extended vowels. |
|
Itrat, A, Jagadheesan, et al |
Indian Journal of Psychiatry |
Healthcare Response | Réponse des soins de santé |
This study aims to describe (1) the characteristics of patients who accessed inpatient treatment, (2) the length of
inpatient stay and readmissions, and (3) the quality and safety of care as indicated by the type of admission (voluntary/compulsory) and seclusion use during the lockdown period. The study and control groups included 104 and 109 patients, respectively. Compared
to the control group, the study group had significantly more patients with separated relationship status, a lower number of severe mental illnesses (SMIs), a higher number of substance use disorders, and lower readmissions. A subanalysis within the lockdown
period showed more voluntary admissions in the initial phase whereas more compulsory admissions in the later phase at trend significance. |
|
|
Ivbijaro, G, Brooks, et al |
Indian Journal of Psychiatry |
Public Health response| Interventions de santé publique |
Aims: To understand the impact of the coronavirus pandemic on mental health, well-being, and dignity, what has helped
and what lessons can be learned to support coping in future. Narrative responses were analyzed using the Gioia approach, a systematic inductive approach to develop concepts that help make sense of socially constructed worlds. Visual ethnographic data was used
to give insight into the participant's socio-cultural context. |
|
|
What mental health experts in Slovakia are learning from COVID-19
pandemic? |
Izakova, L, Breznoscakova, et al |
Indian Journal of Psychiatry |
Healthcare Response | Réponse des soins de santé |
Authors evaluated the psychosocial impact of COVID-19 pandemic on mental health experts and their clinical practice
in Slovakia. Materials and Methods: A total of 157 mental health experts (79% women) submitted their responses via online questionnaire. Results: The most frequent occupation categories were 38.2% outpatient psychiatrists, 26.1% inpatient psychiatrists and
20.4% psychologists. The mental health experts felt maximum of stress during the peak of Slovak COVID-19 crisis, which was identified as the situation just after the declaring the state of emergency by Slovak government. Mental health experts felt mainly personal
stress, then general and working stress. They identified also pathological effect of COVID-19 pandemic on the mental status of their patients, especially with anxiety and affective disorders and advantages of use of telemedicine. |
|
Deep learning based detection and analysis of COVID-19 on chest X-ray images |
Jain, R, Gupta, et al |
Applied Intelligence |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this work, we have taken the PA view of chest x-ray scans for covid-19 affected patients as well as healthy patients.
After cleaning up the images and applying data augmentation, we have used deep learning-based CNN models and compared their performance. We have compared Inception V3, Xception, and ResNeXt models and examined their accuracy. To analyze the model performance,
6432 chest x-ray scans samples have been collected from the Kaggle repository, out of which 5467 were used for training and 965 for validation. In result analysis, the Xception model gives the highest accuracy (i.e., 97.97%) for detecting Chest X-rays images
as compared to other models. |
|
Jamshidi, B, Rezaei, et al |
Disaster Medicine and Public Health Preparedness |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The present paper addresses the modeling and forecasting of the outbreak of COVID-19 in the UK. This modeling has be
accomplished through a two-part time series model to study the number of confirmed cases and deaths. The period we aim at forecast is a 46-day from 15 April to 30 May, 2020. According to the obtained model, we expect that the cumulative number of confirmed
cases reaches 282000 with 80% confidence interval [242000 316500]) on 30th May, from 93873 on 14th April. In addition, it is expected that over this period, the number of daily new confirmed cases falls to the interval 1330 to 6450 with the probability of
0.80 by the point estimation around 3100. Regarding death, our model establishes that the real case fatality rate of the pandemic in the UK approaches 11% (80% confidence interval; 8% - 15%). Accordingly, we forecast that the total death in the UK rises to
35000 (28000-50000 with the probability of 80%). |
|
|
PTSD symptoms among health workers and public service
providers during the COVID-19 outbreak |
Johnson, SU, Ebrahimi, et al |
PLoS One |
Healthcare Response | Réponse des soins de santé |
This cross-sectional, survey-based study collected data from 1773 healthcare workers and public service providers throughout
Norway between March 31, 2020 and April 7, 2020, which encompasses a timeframe where all non-pharmacological interventions (NPIs) were held constant. Post-traumatic stress disorder (PTSD), anxiety and depression were assessed by the Norwegian version of the
PTSD checklist (PCL-5), General Anxiety Disorder –7, and Patient Health Questionnaire-9 (PHQ-9), respectively. Health anxiety and specific predictors were assessed with specific items. Multiple regression analysis was used for predictor analysis. A total of
28.9% of the sample had clinical or subclinical symptoms of PTSD, and 21.2% and 20.5% were above the established cut-offs for anxiety and depression. Those working directly in contrast to indirectly with COVID-19 patients had significantly higher PTSD symptoms.
Worries about job and economy, negative metacognitions, burnout, health anxiety and emotional support were significantly associated with PTSD symptoms, after controlling for demographic variables and psychological symptoms. |
|
Jones, HAS, Salib, et al |
Laryngoscope |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
We evaluated a simple negative-pressure mask technique to reduce viral exposure. The use of a negative-pressure mask
technique resulted in 98% reduction in the fine particulate aerosol simulation and eliminated larger respiratory droplet spread during simulated endoscopic sinus surgery (ESS), including during external drill activation. |
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Jovic, J, Pantovic-Stefanovic, et al |
Indian Journal of Psychiatry |
Public Health response| Interventions de santé publique |
The aim of this study was to explore the use of various Internet contents depending on sociodemographics and on psychiatric
history of participants. A total of 1275 participants across Serbia were recruited. About two-thirds of the sample reported using Internet more during the pandemic. All of the tested regression models, apart from models predicting browsing religion and travel/tourism,
were significant, explaining from about 2% (for the contents specific for COVID-19) up to 34.4% (for the sexual content) of variance of use. Reporting a previously diagnosed psychiatric disorder was a significant predictor of greater Instagram use and browsing
sexual and sport-related content since the pandemic. |
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Kalantari, H, Tabrizi, et al |
Gene Rep |
Epidemiology| Épidémiologie |
We decided to examine suspected samples of pneumonia outbreak caused by the new coronavirus SARS-CoV-2 and provide
information about the mortality rate due to this infection in different age groups in Iran.a total of 784 samples of naso/oropharyngeal swabs of suspected patients with COVID-19 symptoms were examined by RT-PCR method. The highest incidence of the disease
was within the age group of 50–59 years, while the lowest rate was in the 0–9 years age group. The highest rate of positive samples in terms of COVID-19 among suspected individuals was for patients >80 years of age (89%) and the highest mortality rate was
in the age range of 70–79 years (31%) and >80 years (30), respectively. In terms of recovery, the highest rate was in the 30–39 years age group (65.2%). Statistical analysis showed that mortality significantly increased in the age group of >60 years old and
in fact, mortality was significantly associated with older ages. |
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32890736; Developing a pediatric ophthalmology telemedicine program in the COVID-19
crisis |
Kapoor, S, Eldib, et al |
Journal of AAPOS |
Healthcare Response | Réponse des soins de santé |
Purpose: To describe our methodology for implementing synchronous telemedicine during the 2019 novel coronavirus (COVID-19)
pandemic. A total of 237 virtual ophthalmology consult visits were offered during the study period: 212 were scheduled, and 206 were completed, of which 43 were with new patients and 163 with returning patients. Following the initial virtual visit, another
was required on average in 4 weeks by 21 patients; in-person follow-up was required for 170 patients on average 4.6 months after the initial virtual visit. None needed review within 72 hours. The pediatric on-demand service completed 290 visits, of which 25
had eye complaints. |
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Self-Proning in COVID-19 Patients on Low-Flow Oxygen Therapy: A Cluster Randomised Controlled
Trial |
Kharat, Aileen, Dupuis-Lozeron, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé RCT |
Objectives: To test the hypothesis that a simple incentive to self-prone for a maximum of 12 h per day would decrease
oxygen needs in patients admitted to the ward for COVID-19 pneumonia on low-flow oxygen therapy. Twenty-seven patients with confirmed COVID-19 pneumonia admitted to Geneva University Hospitals were included in the study. Ten patients were randomised to self-prone
positioning and 17 to usual care. Self-prone positioning in patients with COVID-19 pneumonia requiring low-flow oxygen therapy resulted in a clinically meaningful reduction of oxygen flow, but without reaching statistical significance. |
|
Pulmonary embolism in COVID-19: Clinical characteristics and cardiac implications |
Kho, J, Ioannou, et al |
American Journal of Emergency Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aim to assess the characteristics of COVID-19 patients diagnosed with pulmonary embolism (PE). We identified 15
COVID-19 patients diagnosed with PE. 2 died (13%), both male patients >70 years. Most common symptoms were dyspnoea (N = 10, 67%) and fever (N = 7, 47%). 12 (80%) reported 7 days or more of non-resolving symptoms prior to admission. 7 (47%) required continuous
positive airway pressure (CPAP), 2 (13%) of which were subsequently intubated. All patients had significantly raised D-dimer levels, lactate dehydrogenase (LDH), C-reactive protein (CRP), ferritin and prothrombin times. The distribution of PEs correlated with
the pattern of consolidation observed on CTPA in 9 (60%) patients; the majority being peripheral or subsegmental (N = 14, 93%) and only 1 central PE. 10 (67%) had an abnormal resting electrocardiogram (ECG), the commonest finding being sinus tachycardia. 6
(40%) who underwent transthoracic echocardiography (TTE) had structurally and functionally normal right hearts. |
|
Kim, J, Volodarskiy, et al |
Journal of the American College of Cardiology |
Clinical data| Données cliniques |
The purpose of this study was to test whether adverse right ventricular (RV) remodeling (dysfunction/dilation) predicts
COVID-19 prognosis independent of clinical and biomarker risk stratification. Adverse RV remodeling predicts mortality in COVID-19 independent of standard clinical and biomarker-based assessment. |
|
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COVID-19 Pneumonia Resembling an Acute
Exacerbation of Interstitial Pneumonia |
Kitayama, T, Kitamura, et al |
Intern Med |
Clinical data| Données cliniques |
An 84-year-old man was admitted with hypoxemia and ground-glass opacities with traction bronchiectasis in both lungs
and mild fibrosis on computed tomography. We first suspected that he had acute exacerbation of interstitial pneumonia and initiated methylprednisolone pulse therapy. On day 4, he was diagnosed with COVID-19 pneumonia. Although the ground-glass opacities were
improved with corticosteroid treatment alone, the hypoxemia persisted, and the plasma D-dimer level increased. Anticoagulant therapy was initiated, and the hypoxemia was improved. |
|
Košir, K, Dugonik, et al |
Educational Studies |
Public Health response| Interventions de santé publique |
The present study aimed to investigate the predictors of work stress in elementary and upper-secondary school teachers
and school counsellors in the initial period of online education in schools during the COVID-19 pandemic. A total of 964 school professionals (90.7% teachers; 9.3% school counsellors) participated in the study. The results indicated that school professionals
who reported higher ICT self-efficacy, had more positive attitudes towards distance education and perceived higher level of supervisor support experienced less stress. In addition, the participants that reported taking care of their own preschool or younger
school children during the schools’ closure reported higher levels of stress. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
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Alpha coma EEG pattern in patients with severe COVID-19 related encephalopathy |
Koutroumanidis, M, Gratwicke, et al |
Clinical Neurophysiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We analysed the electroencephalograms (EEGs) of 19 consecutive patients with laboratory-confirmed COVID-19, performed
at peak disease severity as part of their clinical management. Severe encephalopathy was confirmed in 13 patients, all with severe COVID-19; 10 remained comatose off sedation, and five of them had alpha coma (AC). Disease severity, sedation, immune and metabolic
dysfunction were not different between those with AC and those without. |
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Krati, K, Rizkou, et al |
Pan African Medical Journal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study explains the importance of differential diagnosis between COVID-19 and other lung diseases. we analyzed
in this study, the demographic features, clinical presentations, laboratory data and radiologic findings of the COVID-19 patients in comparison to those with other respiratory infections or diseases. the mean age of all patients was 38.04 years; 35 patients
were later confirmed to be positive for SARS-CoV-2 infection. The most common symptoms reported by both groups included nonproductive cough and myalgia. Two of the non- COVID-19 patients were having below 92% oxygen saturation and low systolic blood pressure.
The patients shared relatively similar laboratory findings except 3% of the non-COVID-19 patients who had lympho-neutropenia and 22.6% had high levels of C-reactive protein. Pulmonary tuberculosis and autoimmune disease respiratory disorder were suspected
in 2 of the non-COVID-19 patients respectively. |
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Kukreja, HemapriyaL, Tigga, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
his study evaluates the knowledge, attitude and practice of various personal safety measures used by the healthcare
professionals. Materials and Methods: After institution ethical committee approval, we conducted an online survey with a preformatted questionnaire consisting of multiple choice questions which assessed the knowledge, attitude and practices adopted by the
various healthcare professionals. The survey was done between 1st - 30th of June 2020 and a total of 536 responses were analyzed. Results: Of the 536 respondents, 90.1% practiced bathing immediately after returning home and 86.8% sanitized their accessories.
86.9% of the professionals used frequent sanitization with use of mask and gloves whereas only 12.3% used full personal protective equipment. 58% of females had used Hydroxychloroquine as prophylaxis whereas only 41% of males used it. Healthcare workers in
younger age group ( 23-40 years ) were more likely to maintain distance with family members and government doctors were significantly more likely to do so ( p< 0.001 ) as compared to private practitioners. |
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Kumar, Durgesh, Kumari, et al |
Research Square prepub |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Herein, the authors have selected the antiviral drug, acyclovir for the inhibition of protease of the SARS-CoV-2. Herein,
simulations method were used to calculate relative change in binding free energy under the influence of Amber force field through MM-GBSA. The structural behavior of complex system with acyclovir and its derivatives were observed in term of RMSD and RMSF for
all residues. Authors observed that complex of CMPD3 with the protease is stable and has less fluctuation than the native protease. Further, CMPD3 follow the creteria of all drug likeness term and it showed good activity against SARS-CoV-2. It was suggested
that CMPD3 may be used as a inhibitor for coronavirus activity. |
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The analysis of a time delay fractional COVID-19 model via Caputo type fractional derivative |
Kumar, P, Suat Erturk, et al |
Mathematical Methods in the Applied Sciences |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, we solved a time delay fractional COVID-19 SEIR epidemic model via Caputo fractional derivatives using
a predictor–corrector method. We provided numerical simulations to show the nature of the diseases for different classes. We derived existence of unique global solutions to the given time delay fractional differential equations (DFDEs) under a mild Lipschitz
condition using properties of a weighted norm, Mittag–Leffler functions and the Banach fixed point theorem. For the graphical simulations, we used real numerical data based on a case study of Wuhan, China, to show the nature of the projected model with respect
to time variable. We performed various plots for different values of time delay and fractional order. We observed that the proposed scheme is highly emphatic and easy to implementation for the system of DFDEs. |
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Kuroyedov, AV, Zavadski, et al |
Oftalmologiya |
Healthcare Response | Réponse des soins de santé |
Purpose. To study the influence of personal protective equipment (PPE) of the respiratory and visual systems on the
development and progression of dry eye syndrome (DES) and its relationship with other risk factors for medical workers. The data of 243 people (male - 22.2 %, female - 77.8 %) were analyzed as part of a multi-center analytical scientific one-step study. The
negative influence of various PPE of the respiratory system and eye on the total tear production was established. The decrease in the results of the Schirmer I test by the end of the working day was 20-25 % of the basic level, regardless of the presence of
traditional risk factors for DES. The severity of changes depended on the type of PPE used. The data obtained are particularly relevant during the new COVID-19 coronavirus pandemic and justify the need to establish specific prophylactic measures. |
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Lefrant, Jean-Yves, Fischer, et al |
SSRN- Lancet prepublication |
Healthcare Response | Réponse des soins de santé |
The present study reports how the French Health Care system created temporary ICU beds to avoid being overwhelmed.
Methods: All French ICUs were contacted for answering a questionnaire focusing on the available beds and health care providers before and during the outbreak. Results: During the outbreak, 4,806 new ICU beds (+95% increase) were created from Acute Care Unit
(ACU, 2,283), Post Anesthetic Care Unit and Operating Theatre (PACU & OT, 1,522), Other Units (374) or real build-up of new ICU beds (627), respectively. At the peak of the outbreak, 9,860, 1,982 and 3,089 ICU, ACU and PACU beds were made available. Before
the outbreak, 3,548 physicians, 1,785 residents, 11,023 nurses and 6,763 nursing auxiliaries worked in established ICUs. During the outbreak, 2,524 physicians, 715 residents, 7,722 nurses and 3,043 nursing auxiliaries supplemented the usual staff in all ICUs.
3,212 new ventilators were added to the 5,997 initially available in ICU. |
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Li, JB, Yang, et al |
BMC Public Health |
Public Health response| Interventions de santé publique |
This study examined three cognitive appraisals (i.e., perceived severity, perceived controllability, and knowledge
of COVID-19) and their associations with a wide range of emotional and behavioral outcomes among the Chinese public. Participants were 4607 citizens (age range: 17–90 years, Mage = 23.71 years) from 31 provinces in China and they took part in a cross-sectional
survey online. The results showed that the public’s emotional and behavioral reactions were slightly affected by the outbreak of COVID-19. Moreover, the public had limited participation in the events regarding COVID-19 but actively engaged in precautionary
behavior. In addition, results of structural equation model with latent variables revealed that the three appraisals were differentially related to the outcome variables (i.e., negative emotion, positive emotion, sleep problems, aggression, substance use,
mobile phone use, social participation, and precautionary behavior). |
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Li, Jianying, Zhao, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
This study aimed to investigate the knowledge and needs of physical fitness and breathing training, and to explore
the impact of physical fitness and breathing training on COVID-19 patients. According to a 5-point Likert scale, the 133 COVID-19 patients had only an "not really" and "uncertain" knowledge of physical fitness and breathing training (2.47±1.17). 86.98% of
the patients expected to receive guidance of physical fitness and breathing training through video teaching. Differences were observed in fatigue, General fatigue component (15.0(8.0) vs. 19.0(10.0), P<0.01); Functional ability component (4.0 (3.0) vs. 7.0(4.0),
P<0.01); Psychological component (6.0(5.0) vs.7.0 (5.0), P<0.01), after the intervention, Moderate degree (36.09% vs. 28.57%) alleviated to mild degree (51.12% vs. 66.91%). SpO2-% 86 ((75, 89) vs. 92(89, 98), P<0.001), and Oxygen flow-L/min (2(0,4) vs. 8(3,9),
P<0.001). In our study, 130 healthcare professionals took part in this program. None of the participants reported covid-19 related symptoms. When the participants returned home, they all tested negative for SARSCoV- 2 specific nucleic acids and IgM or IgG
antibodies (95% confidence interval 0.0 to 0.7%). |
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Analysis of viral nucleic acid and cytokines in 12 children with 2019-nCoV
infection |
Li, X, Fang, et al |
Chinese Journal of Microbiology and Immunology (China) |
Clinical data| Données cliniques |
Objective: To analyze the viral nucleic acid and cytokines in 12 children with 2019-nCoV infection. A total of 12 children
were enrolled in this study. There were two asymptomatic, five mild and five common cases. No severe or critical cases were involved. The overall levels of serum cytokines IL-17A, IL -4 and IL-5 in different stages of the disease (early, intermediate and convalescence
stage) were statistically different (Z or F, P values were 8.33, 0.016; 5.36, 0.010 and 6.56, 0.004, respectively), and a significant increase was observed in the intermediate stage of infection. IL-17F, IL-2 and IL-22 were all increased during the infection,
but there was no significant statistical difference among the three stages (P>0.05). |
|
Liang, Y, Chang, et al |
International Journal of COPD |
Clinical data| Données cliniques |
We aimed to investigate the change of respiratory symptoms, pharmacological treatment and healthcare utilization of
COPD patients during the epidemic in Beijing, China. A total of 153 patients were enrolled for analysis. During the COVID-19 epidemic in Beijing, most of our COPD patients maintained their long-term pharmacological treatment and had mild-to-moderate symptoms.
Approximately, 30.0% of the patients experienced worsening of respiratory symptoms, but most of them did not seek medical care in the hospital due to concerns about cross-infection. |
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Lin, CH, Lin, et al |
Cost Eff Resour Alloc |
Public Health response| Interventions de santé publique |
The objective of this study was to foster equality and cost-effectiveness in the distribution and sale of masks to
all Taiwanese citizens, in response to the COVID-19 pandemic. All 6336 special community pharmacies participating in the NHI (National Health Insurance) served as mask-selling sites. Implementing the program has provided equal access to masks for all citizens
across Taiwan. It has stabilized the pricing of masks and mitigated the public’s anxiety of a perceived likely market shortage. The community pharmacy-based approach to the distribution of prevention face masks to citizens represents a new and innovative engagement
of pharmacists in public health promotion and protection initiatives. |
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Lin, CH, Yang, et al |
Biomedicines |
Coronavirology| Coronavirologie |
bovine coronavirus (BCoV), which is in the same genus as SARS-CoV-2, was used as a test model and the findings were
as follows. With the treatment of antiviral remdesivir, the selected BCoV variant with an altered genome structure developed resistance, but its pathogenicity was not increased in comparison to that of wild type (wt) BCoV. Under the selection pressure of innate
immunity, the genome structure was also altered; however, neither resistance developed nor pathogenicity increased for the selected BCoV variant. Furthermore, both selected BCoV variants showed a better efficiency in adapting to alternative host cells than
wt BCoV. In addition, the previously unidentified feature that the spike protein was a common target for mutations under different antiviral treatments might pose a problem for vaccine development because spike protein is a common target for antibody and vaccine
designs. |
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Lindner, P, Forsström, et al |
Frontiers in Public Health |
Public Health response| Interventions de santé publique |
Total gambling activity decreased by 13.29% during the first phase of the outbreak compared to forecast. Analyses of
online gambling data revealed that although betting decreased substantially in synchrony with a slight increase in online casino gambling, there was no increase in likely problematic, high-intensity gambling and neither did total online gambling increase. |
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Liu, Ye, Lu, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated whether diabetes, particularly undiagnosed diabetes, was associated with an increased risk of death
from COVID-19. Of 373 patients, 233 were included in the final analysis, among whom 80 (34.3%) had diabetes: 44 (55.0%) reported a diabetes history, and 36 (45.0%) were newly defined as having undiagnosed diabetes by HbA1c testing at admission. Compared with
the non-diabetes group, the overall diabetes group had a significantly increased mortality rate (22.5% vs 5.9%, p <0.001). Moreover, the overall, diagnosed, and undiagnosed diabetes groups displayed lower survival probability in the Kaplan-Meier survival analysis
(all p <0.01). Using multivariate Cox regression, diabetes, age, quick sequential organ failure assessment score, and D-dimer ≥ 1.0 mg/mL were identified as independent risk factors for in-hospital death in patients with COVID-19. |
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Factors Predicting Willingness to Share COVID-19 Misinformation |
Lobato, EJC, Powell, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
We conducted a preregistered exploratory survey to assess whether patterns of individual differences in political orientation,
social dominance orientation (SDO), traditionalism, conspiracy ideation, or attitudes about science predict willingness to share different kinds of misinformation regarding the COVID-19 pandemic online. Analyses revealed two orthogonal models of individual
differences predicting the willingness to share misinformation over social media platforms. Both models suggest a sizable role of different aspects of political belief, particularly SDO, in predicting tendencies to share different kinds of misinformation,
predominantly conspiracy theories. Although exploratory, results from this study can contribute to the formulation of a socio-cognitive profile of individuals who act as vectors for the spread of scientific misinformation online, and can be useful for computationally
modeling misinformation diffusion. |
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Ma, Shuang, Li, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The aim of this stud is to assess the associations of key built environment factors, which create spaces for activities
— “inferred activity” rather than “actually observed activity” — with the spread of COVID-19 in China at its initial stage. In this nationwide study, we used a random forest (RF) approach to objectively assess the associations between the built environment
factors and the spread of COVID-19. The spread is measured for 2 994 township-level administrative units in China. The spread of COVID-19 had obvious spatial agglomerations all across China. Clusters with both low ratio of cumulative infection cases (RCIC)
and low coefficient of variation of infection cases (CVIC) at the same locations (Low-Low type) show the largest percentage, and are followed by the Low-High type. The Low-High type is more dangerous because clusters of low RCIC are surrounded by clusters
with high CVIC which means that policy measures taken in the initial stage may be less effective to prevent/mitigate a rapid disease spread at these locations. The findings from this study do not support nationwide uniform measures against COVID-19. The built
environment factors may be associated with mitigating or accelerating the spread of COVID-19. |
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32997070; Factors associated with COVID-19 hospital deaths in Espírito Santo,
Brazil, 2020 |
Maciel, EL, Jabor, et al |
Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to analyze factors associated with the deaths of individuals hospitalized with COVID-19 in
the state of Espírito Santo, Brazil. This was a cross-sectional study using secondary data. Logistic regression models were used to estimate crude and adjusted odds ratios (OR). As at May 14, 2020, 200 individuals had been discharged and 220 had died. In
the adjusted analysis, hospital mortality was higher for the 51-60 age group (OR=4.33 - 95%CI 1.50;12.46), the over 60 age group (OR=11.84 - 95%CI 4.31;32.54), cases notified by public institutions (OR=8.23 - 95%CI 4.84;13.99) and cases with a greater number
of comorbidities (two OR=2.74 - 95%CI 1.40;5.34] and three OR=2.90 - 95%CI 1.07;7.81]). Higher mortality was found in older individuals, those with comorbidities and users of public hospitals. |
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Malizia, A, Filograna, et al |
International Journal of Safety and Security Engineering |
Healthcare Response | Réponse des soins de santé |
The authors in this paper consider the pandemic outbreak of SARS-COV-2 as a case study and propose virtual autopsy
by postmortem CT (PMCT) as a technique to facilitate post-mortem examinations on ascertained or suspected SARS-COV-2 cases. This method reduces the risk of infection for the operators that have to conduct the particular investigations during the emergencies. |
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Mamun, MA, Akter, et al |
Heliyon |
Public Health response| Interventions de santé publique |
A web-based cross-sectional study was administered through the social media platforms to asses the elevated psychological
sufferings including suicidality of health-care providers (HCPs) and the general public. A web-based cross-sectional study was administered through the social media platforms. A total 3,388 respondents took part in the survey among them 834 were frontline
HCPs. Regression analysis showed that being female, being divorced, and having no child were emerged as independent predictors for suicidality. There was no significant association between the PPE-related or patient-care related variables and suicidal behavior
of the HCPs. |
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Margus, C, Sondheim, et al |
American Journal of Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
This study seeks to characterize Emergency Department (ED) discharges suspected of Covid-19 that are admitted within
72 h. We abstracted all adult discharges with suspected Covid-19 from five New York City EDs between March 2nd and April 15th.Discharged ED patients returning within 72 h were more often admitted if suspected of Covid-19. Several factors emerge as associated
with 72-h ED return admission in subjects suspected of Covid-19. These should be considered when assessing discharge risk in clinical practice. |
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Plasma hemostatic system in patients with the novel coronavirus disease 2019 (COVID-19) |
Markelov, MI, Beznoshchenko, et al |
Akusherstvo i Ginekologiya (Russian Federation) |
Clinical data| Données cliniques |
The aim of this study is to investigate plasma hemostasis in patients with different levels of COVID-19 severity. The
study included 46 patients with confirmed COVID-19, who were stratified into four groups based on disease severity as mild (1), moderate (2), severe (3), and critically severe (4). D-dimer concentration >450 ng/ml was found in 100% of patients increasing from
973 (545–1635) ng/ml in group 1 to 13513 (7627–22512) ng/ml in group 4 (p 3633 ng/ml (specificity 92.3%, sensitivity 100%, AUC 0.94, p <0.001, positive predictive value 99.1%, and negative predictive value 100%) and ATIII <70.8% (specificity 70%, sensitivity
82.6%, AUC 0.85, p <0.001, positive predictive value 30.5%, and negative predictive value 96.1%). The levels of D-dimer, fibrinogen, and ATIII were found to be associated with the severity of COVID-19. |
|
Marr, KA, Platt, et al |
Emerg Infect Dis |
Clinical data| Données cliniques |
Recently, coronavirus disease-associated pulmonary aspergillosis (CAPA) has been detected through rapid reports, primarily
from centers in Europe. We provide a case series of CAPA, adding 20 cases to the literature, with review of pathophysiology, diagnosis, and outcomes. The syndromes of pulmonary aspergillosis complicating severe viral infections are distinct from classic invasive
aspergillosis, which is recognized most frequently in persons with neutropenia and in other immunocompromised persons. Combined with severe viral infection, aspergillosis comprises a constellation of airway-invasive and angio-invasive disease and results in
risks associated with poor airway fungus clearance and killing, including virus- or inflammation-associated epithelial damage, systemic immunosuppression, and underlying lung disease. Radiologic abnormalities can vary, reflecting different pathologies. |
|
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Martínez-Sanz, J, Muriel, et al |
Clinical Microbiology and Infection |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study investigated the association between receipt of tocilizumab and mortality in a large cohort of hospitalized
patients. In this cohort study of patients hospitalized with COVID-19 in Spain, the primary outcome was time to death and the secondary outcome time to intensive care unit (ICU) admission or death. Data from 1229 patients were analysed, with 261 patients (61
deaths) in the tocilizumab group and 969 patients (120 deaths) in the control group. ocilizumab was associated with decreased risk of death (adjusted hazard ratio 0.34, 95% confidence interval 0.16–0.72, p 0.005) and ICU admission or death (adjusted hazard
ratio 0.39, 95% confidence interval 0.19–0.80, p 0.011) among patients with baseline CRP >150 mg/L but not among those with CRP ≤150 mg/L. In this large observational study, tocilizumab was associated with a lower risk of death or ICU admission or death in
patients with higher CRP levels. |
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Matsubara, D, Kauffman, et al |
Journal of the American College of Cardiology |
Clinical data| Données cliniques |
This study aimed to analyze echocardiographic manifestations in multisystem inflammatory syndrome in children (MIS-C).
A total of 28 MIS-C, 20 healthy control subjects and 20 classic Kawasaki disease (KD) patients were retrospectively reviewed. Only 1 case in the MIS-C group (4%) manifested coronary artery dilatation (z score = 3.15) in the acute phase, showing resolution
during early follow-up. Left ventricular (LV) systolic and diastolic function measured by deformation parameters were worse in patients with MIS-C compared with KD. he strongest parameters to predict myocardial injury in MIS-C were global longitudinal strain,
global circumferential strain, peak left atrial strain, and peak longitudinal strain of right ventricular free wall (odds ratios: 1.45 [95% confidence interval (CI): 1.08 to 1.95], 1.39 [95% CI: 1.04 to 1.88], 0.84 [95% CI: 0.73 to 0.96], and 1.59 [95% CI:
1.09 to 2.34], respectively). Unlike classic KD, coronary arteries may be spared in early MIS-C; however, myocardial injury is common. |
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Can urine be a potential biohazard in times of SARS-CoV-2 pandemic? |
Mattos, EC, Matsuda, et al |
J Med Virol |
Transmission Clinical data| Données cliniques |
The new coronavirus SARS-CoV-2 causes asymptomatic infections to severe conditions, which has been revealed as a systemic
disease. It is transmitted through respiratory droplets and contact, however other routes as airborne transmission have been suggested. Measures to prevent transmission are the bases to control the pandemic. We report a case of hematuria in which SARS-CoV-2
was detected by RT-PCR in the urine of an asymptomatic patient. This work intends to alert about the handling of urine samples as a potential biohazard, also concerning physicians about non-specific symptoms caused by this virus, which can compromise the urinary
system without respiratory symptoms. This article is protected by copyright. All rights reserved. |
|
Mautner, L, Baillie, et al |
Virol J |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here we report the development of a loop-mediated isothermal amplification (LAMP) based method to detect SARS-CoV-2
genes ORF8 and N directly from pharyngeal swab samples. The assay is sensitive and highly specific for SARS-CoV-2 detection, showing no cross reactivity when tested on 20 other respiratory pathogens. The assay is 12 times faster and 10 times cheaper than routine
reverse transcription real-time polymerase chain reaction, depending on the assay used. he fast and easy to handle RT-LAMP assay amplifying specifically the genomic regions ORF8 and N of SARS-CoV-2 is ideally suited for POCT at e.g. railway stations, airports
or hospitals. |
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McLean, RC, Young, et al |
International Journal of Surgery |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to investigate a possible ‘lockdown’ effect on the volume and severity of surgical admissions
and their outcomes. Two separate cohorts of adult emergency general surgery inpatient admissions 30 days immediately before (February 16, 2020 to March 15, 2020), and after UK government advice (March 16, 2020 to April 15, 2020). Following lockdown, a significant
reduction in median daily admissions from 7 to 3 per day (p < 0.001) was observed. Post-lockdown patients were significantly older, frailer with higher inflammatory indices and rates of acute kidney injury, and also were significantly more likely to present
with gastrointestinal cancer, obstruction, and perforation. Patients had significantly higher rates of Clavien-Dindo Grade ≥3 complications (p = 0.001), all cause 30-day mortality (8.5% vs. 2.9%, p = 0.028), but no significant difference was observed in operative
30-day mortality. There appears to be a “lockdown” effect on general surgical admissions with a profound impact; fewer surgical admissions, more acutely unwell surgical patients, and an increase in all cause 30-day mortality. |
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Milenković, DA, Dimić, et al |
RSC Advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study reviews three previously synthesized coumarin derivatives and their Pd(ii) complexes. They were examined
for the binding affinity towards the Mproprotein of SARS-CoV-2 by molecular docking and compared to two Food and Drug Administration (FDA) drugs,cinanserinandchloroquine. All of the investigated compounds bind to the active position of the mentioned protein.
Coumarin-Pd(ii) complexes showed higher binding affinities compared to the approved drugs. The bindings of the bis(3-(1-((3-chlorophenyl)amino)ethylidene)-chroman-2,4-dione) palladium(ii) complex, its corresponding ligand, andcinanserinto SARS-CoV-2 Mprowere
further subjected to the molecular dynamics simulations. The binding free energies, computed by MM/PBSA approach were analyzed in detail and the importance of specific interactions outlined. These results showed that the molecules bearing structural similarity
to the approved drugs and their complexes have the potential to inhibit the functional activity of SARS-CoV-2 protease and further experimental studies should be undertaken |
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Milgrom, Y, Tal, et al |
Isr J Health Policy Res |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to assess how an administrative decision to operate one hospital as a COVID-19 treatment
hospital (CTH) and to have the second function as a non-COVID-19 treating hospital (NCTH) affected hospital worker anxiety. From April 27 to May 1, during the COVID-19 pandemic in Israel, while the country was under lock-down, an electronic questionnaire survey
was carried out among hospital workers of the CTH and NCTH. Completed questionnaires were received from 1570 hospital employees (24%). Multivariable regression analysis showed that being a resident doctor (odds ration OR] 2.13; 95% CL, 1.41-3.23; P = 0.0003),
age ≤ 50 (OR, 2.08; 95% Cl, 1.62-2.67; P < .0001), being a nurse (OR, 1.29; 95% CL, 1.01-1.64; P = 0.039), female gender (OR, 1.63; 95% CL, 1.25-2.13; P = 0.0003) and having risk factors for COVID-19 (OR, 1.51; 95% CL, 1.19-1.91; P = 0.0007), but not hospital
workplace (p = 0.08), were associated with the presence of clinical anxiety. y multivariable analysis the creation of a NCTH during the COVID-19 pandemic was not found to be associated with a decrease in the number of hospital workers with clinical anxiety. |
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Miyani, B, Fonoll, et al |
Journal of Environmental Engineering (United States) |
Epidemiology| Épidémiologie |
Untreated wastewater samples were collected from the Great Lakes Water Authority (GLWA) Water Resource Recovery Facility
(WRRF) located in southeast Michigan between April 8 and May 26, 2020. A total of 54 untreated wastewater samples were collected. Viruses were eluted and concentrated and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) concentrations were quantified
with reverse transcription quantitative polymerase chain reaction (RT-qPCR). SARS-CoV-2 was detected in 100% of samples, and measured concentrations were in the range of 104-105 genomic copies/L. uantification of concentrations of human viruses, such as SARS-CoV-2,
in wastewater is a critical first step in the development of wastewater-based epidemiology predictive methods. |
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Air Quality Response in China Linked to the 2019 Novel Coronavirus (COVID-19) Lockdown |
Miyazaki, K, Bowman, et al |
Geophysical Research Letters |
Public health interventions*| Interventions de santé publique |
Here, we quantify the ancillary impacts on air pollution and human health using inverse emissions estimates based on
multiple satellite observations. We find that Chinese NOx emissions were reduced by 36% from early January to mid-February, with more than 80% of reductions occurring after their respective lockdown in most provinces. The reduced precursor emissions increased
surface ozone by up to 16 ppb over northern China but decreased PM2.5 by up to 23 μg m−3 nationwide. Changes in human exposure are associated with about 2,100 more ozone-related and at least 60,000 fewer PM2.5-related morbidity incidences, primarily from asthma
cases, thereby augmenting efforts to reduce hospital admissions and alleviate negative impacts from potential delayed treatments. |
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Patient Perceptions about Professional Dental Services during the COVID-19 Pandemic |
Moffat, RC, Yentes, et al |
JDR Clin Trans Res |
Public Health response| Interventions de santé publique |
The purpose of this study was to explore dental patients' perceptions of susceptibility to contracting COVID-19, their
related attitudes and beliefs regarding dental care visits, and their considerations for returning to routine care during and after the pandemic. Data for this cross-sectional study came from an electronic survey of 464 US adults. Perceptions of susceptibility,
a higher valuation of dentistry, and agreement that COVID-19 is a serious infection were each positively related to attitudinal statements and beliefs reflecting caution in attending dental visits. This study provides early data about patient perceptions of
susceptibility and attitudes toward COVID-19 in a professional dental setting and necessary conditions for returning to regular visits. |
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Intricacies in characterizing positivity in pooled sample testing for SARS-CoV-2 |
Mohanty, S, Ravindra, et al |
J Med Virol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Considering the possibility of dilution factor in pool testing, an attempt was made to find out possibility of any
true positive sample/s in pools with late amplification. The study was conducted on samples received from various collection centres in different districts of Odisha as well as from patients attending the screening clinic or admitted in COVID ward of the hospital.
Inclusion of an additional criteria of probable positive pool (Ct value >35 with non-sigmoid amplification curve or showing a line of amplification towards the end of the cycle) yielded 39 (15.5%) more true positive samples out of a total of 251 positive samples
that would otherwise have been missed if only the classical criteria of positive (Ct within 35 with proper sigmoid curve) had been considered. The study highlights the importance of considering any indication of late amplification in the RT-PCR test to label
a pool as positive to avoid missing any true positive sample in the pool. |
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Morsy, S |
Medical hypotheses |
Coronavirology| Coronavirologie Immunology | Immunologie |
This study aimed at identifying human neural proteins that can be attacked by cross-reacting SARS-COV-2 antibodies
causing Guillain-Barré syndrome (GBS). To achieve this goal, proteins implicated in the development of GBS were retrieved from literature. These human proteins were compared to SARS-COV-2 surface proteins to identify homologous sequences using Blastp. Then,
MHC-I and MHC-II epitopes were determined in the homologous sequences and used for further analysis. Neural cell adhesion molecule is the only neural protein that showed homologous sequence to SARS-COV-2 envelope protein. The homologous sequence was part of
HLA-A68 and HLA-DQA/HLA-DQB epitopes had a similar binding pattern to SARS-COV-2 envelope protein. Based on these results, the study suggests that NCAM may play a significant role in the immunopathogenesis of GBS. |
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Mosquera-Yuqui, F, Lopez-Guerra, et al |
J Biomol Struct Dyn |
Therapeutics| Thérapeutique |
In this study, 92 phytochemicals from medicinal plants growing in the Andean region were screened against SARS-CoV-2
3 C-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp) in their active sites through molecular docking. The cutoff values were set from the lowest docking scores of the FDA-approved drugs that are being used to treat COVID-19 patients. Computational
analyses revealed that the interaction with hesperidin (theoretical binding energies, ΔG(bind) = -15.18 kcal/mol to 3CLpro and ΔG(bind) = -9.46 kcal/mol to RdRp) remained stable in both enzymes, unveiling its remarkable potential as a possible multitarget
antiviral agent to treat COVID-19. Importantly, lupinifolin with an estimated binding affinity to 3CLpro higher than hesperidin (ΔG(bind) = -20.93 kcal/mol) is also a potential inhibitor of the 3CLpro. These two compounds displayed suitable pharmacological
and structural properties to be drug candidates, demonstrating to be worthy of further research. |
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32889073; The impact of the COVID-19 pandemic on vascular surgery practice in the
United States |
Mouawad, NJ, Woo, et al |
Journal of Vascular Surgery |
Healthcare Response | Réponse des soins de santé |
This study describes the impact of the pandemic on the practices of vascular surgeons in the United States. The Pandemic
Practice, Anxiety, Coping, and Support Survey for Vascular Surgeons is an anonymous cross-sectional survey sponsored by the Society for Vascular Surgery Wellness Task Force disseminated April 14 to 24, 2020. A total of 535 vascular surgeons responded to the
survey from 45 states. There was no regional variation in the presence of preoperative COVID-19 testing, COVID-19 OR protocols, adherence to national surgical standards, or the availability of personal protective equipment. The overwhelming majority of respondents
(91.7%) noted elective surgery cancellation, with the Northeast and Southeast regions having the most case cancellations 94.2% and 95.8%, respectively. The Northeast region reported the highest percentage of operations or procedures on patients with COVID-19.
More than one-half of office-based laboratories (OBLs) were closed, although there was regional variation with more than 80% in the Midwest being closed. Vascular surgeons in the United States report substantial impact on their practices during the COVID-19
pandemic, and regional variations are demonstrated, particularly in OBL use, intensive care bed availability, and COVID-19 exposure at work. |
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A pooled testing strategy for identifying SARS-CoV-2 at low prevalence |
Mutesa, L, Ndishimye, et al |
Nature |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study proposes an algorithm for pooling subsamples based on the geometry of a hypercube that, at low prevalence,
accurately identifies infected individuals in a small number of tests and rounds of testing. it reports proof of concept experiments in which a positive subsample was detected even when diluted 100-fold with negative subsamples (cf. 30-fold to 48-fold dilution
in Refs. (9-11)). The use of group testing on a massive scale to closely and continually monitor infection in a population, along with rapid and effective isolation of infected people, provides a promising pathway to the longterm control of COVID-19. |
|
Nagler, RH, Vogel, et al |
PLoS One |
Public Health response| Interventions de santé publique |
This study fielded a nationally representative survey of U.S. adults in late April 2020 (N = 1,007). Results showed
substantial self-reported exposure to conflicting information about COVID-19, with nearly 75% of participants reporting having recently heard such information from health experts, politicians, and/or others. Participants perceived disagreement across a range
of COVID-19-related issues, though from politicians more than health experts. Factors including political affiliation, information source use, and personal experience with COVID-19 were associated with perceptions of disagreement. |
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Natarajan, MK, Wijeysundera, et al |
CJC Open |
Healthcare Response | Réponse des soins de santé |
This study compared cardiac catheterization procedures for ST-elevation myocardial infarction (STEMI) between January
1 and May 10, 2020 to the same time frame in 2019. From March 16 to May 10, 2020, after implementation of provincial directives, STEMI cases significantly decreased by up to 25%. STEMI cases across Ontario have been substantially affected during the COVID-19
pandemic. |
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Naydenova, Katerina, Muir, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study reports the structure of favipiravir ribonucleoside triphosphate (favipiravir-RTP) in complex with the SARS-CoV-2
RNA-dependent RNA polymerase (RdRp) bound to a template:primer RNA duplex, determined by electron cryomicroscopy (cryoEM) to a resolution of 2.5 Ang. The structure shows clear evidence for the inhibitor at the catalytic site of the enzyme, and resolves the
conformation of key side chains and ions surrounding the binding pocket. Polymerase activity assays indicate that the inhibitor is weakly incorporated into the RNA primer strand, and suppresses RNA replication in the presence of natural nucleotides. The structure
reveals an unusual, non-productive binding mode of favipiravir-RTP at the catalytic site of SARS-CoV2 RdRp which explains its low rate of incorporation into the RNA primer strand. Together, these findings inform current and future efforts to develop polymerase
inhibitors for SARS coronaviruses. |
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Responsibilities of archivist now and in the future as the result of COVID – 19;
Case of ICA-SUV |
Netshakhuma, NS |
Digital Library Perspectives |
Public Health response| Interventions de santé publique |
The purpose of this study was to examine the strategies for the preservation of archival materials in the International
Council on Archives Section on University and Research Institution Archives (ICA SUV) by the members and to make recommendations for the digital archival preservation to continue its accessibility during the national lockdown because of COVID–19. The study
used a survey research methodology through e-mails as data collection instruments. The key findings revealed that most of the sections on university and research institution archives lack digitization preservation strategies and most of their records are not
accessible online, as most of their collections are still preserved manually through the paper-based system; furthermore, archivists are not fully trained on digital management. The paper recommends universities to develop preservation strategies to migrate
records from the paper-based system to electronic records management system. |
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COVID-19 Result Follow-up Process in the Pediatric Emergency Department Setting |
Newman, S, Simpson, et al |
Disaster Med Public Health Prep |
Healthcare Response | Réponse des soins de santé |
This article describes the novel process which ensured timely notification of testing results, enabled patients to
speak remotely with ED providers, increased patient and staff safety by reducing unnecessary exposures and suggested a good patient experience. With over 1900 patients discharged pending their COVID results, the program is successful. We anticipate expansion
into antibody testing and notification as the pandemic progresses. |
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Solutions to prevent and address physician burnout during the
pandemic in Mexico |
Ng, B |
Indian Journal of Psychiatry |
Healthcare Response | Réponse des soins de santé |
Aims and Objectives: Design a program to address the emotional and psychiatric needs of COVID-19 first response Healthcare
personnel in Mexico. Materials: in march 2020, the Mexican Psychiatric Association was invited to be part of the Workgroup for the fortification of Mental Health during Disasters of the Ministry of Health in Mexico. Results: The program was launched in two
phases. Phase A through a chat with text messaging capability was launched on 25 April, 2020. B through telepsychiatric video calls, was launched on 15 June, 2020. Phase A had a very limited demand. Phase B also had a very limited demand until the month 5
September, 2020. Conclusions: from the time of program launch through the first four months, the demand was very low, what may be explained due to 'normalization' of stress and/or stigma among healthcare professionals. |
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Assessing the impact of COVID-19 on bike-sharing usage: The case of thessaloniki, Greece |
Nikiforiadis, A, Ayfantopoulou, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
his study attempts to investigate the impact that COVID-19 had on travelers' perceptions towards bike-sharing systems
and whether the pandemic could result in a greater or lesser share of trips that are being conducted through shared bikes. Responses of 223 people were analyzed statistically. The results of the analysis show that COVID-19 will not affect significantly the
number of people using bike-sharing for their trips. The results indicate that bike-sharing is now more likely to become a more preferable mobility option for people who were previously commuting with private cars as passengers (not as drivers) and people
who were already registered users in a bike-sharing system. |
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Noreen, K, Umar, et al |
Pakistan Journal of Medical Sciences |
Healthcare Response | Réponse des soins de santé |
This study was conducted to explore factors that can impact psychological health and coping strategies to help health
care professionals (HCPs) to perform their duties. cross sectional survey was conducted using structured questionnaire electronically shared with the participants after ethical approval. urvey was completed by 250 participants. Lack of evidence-based guidelines
for patient management, news about pandemic situation through media and to deal with uncooperative patients not willing for quarantine added to their stress. Receiving honour and respect from general public in recognition of services, monetary benefit, adequate
training to treat COVID-19, provision of personal protective equipment from government were reported as coping strategies for psychological impact. COVID-19 outbreak had psychological impact on HCPs, yet they continued to perform their duties carefully as
moral obligation. |
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Oo, Adrian, Zandi, et al |
SSRN- Lancet prepublication |
Coronavirology| Coronavirologie Immunology | Immunologie |
In this study, we established an in vitro tissue culture model system of macrophages, in which SAMHD1 was absent as
a result of CRISPR-Cas9 gene modification or proteosomal degradation by lentiviral Vpx. SARS-CoV-2 and HCoV-OC43 replications were suppressed in differentiated SAMHD1 K/O THP-1 cells. Similarly, when SAMHD1 was degraded in VLP Vpx (+) treated primary monocyte-derived
macrophages, lower levels of SARS-CoV-2 replication were observed. The loss of SAMHD1 in the macrophage-like THP-1 cells resulted in enhanced gene expression of IFNs and different innate immunity signaling pathways. Overall, our macrophage model suggested
that elevated innate immune response and IFNs activation via genetic loss of SAMHD1, effectively suppressed SARS-CoV-2 replication. |
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Ougrin, Dennis, Wong, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
This study uses electronic patient records from 23 hospital emergency departments in 10 countries to examine differences
in hospital emergency psychiatric presentations for self-harm of youths through age 18 in March and April 2020 compared with the same period in 2019. he total number of emergency psychiatric hospital presentations decreased from 1,239 in 2019 to 834 in 2020,
IRR 0·67, 95% CI 0·62-0·73. The proportion of youths presenting with self-harm increased from 50% in 2019 to 57% in 2020, OR 1·33, 95% CI 1·07-1·64, but there was no difference in the proportion presenting with severe self-harm. Within self-harm presentations,
the proportion of youths with emotional disorders increased from 58% to 66%, OR 1·58, 95% CI 1·06-2·36. The proportion of youths admitted to an observation ward also decreased from 13% to 9% in 2020, OR 0·52, 95% CI 0·28 to 0·96. During lockdowns, there are
likely to be fewer hospital emergency psychiatric presentations. |
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Organization of mental healthcare in Bosnia and Herzegovina during
coronavirus disease 2019 pandemic |
Pajevic, I, Hasanovic, et al |
Indian Journal of Psychiatry |
Healthcare Response | Réponse des soins de santé |
The present study has been done to explore the organization of psychiatric services in Bosnia and Herzegovina (BH)
to meet mental health needs of BH citizens during the particular restrictive measures caused by COVID-19 pandemic. This online survey has been done for BH psychiatric institutions. Data were collected from psychiatric institutions in the mental health network
of BH. A total of 38 complete responses have been received. During the COVID-19 pandemic in BH, all psychiatric services functioned on a reduced scale, adhering to measures to protect and self-protect staff and service users. All patients who asked for help
have been adequately treated in direct inpatient or outpatient mental healthcare or online, despite telepsychiatric services not being recognized in health system in BH. |
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Pakravan-Charvadeh, M, Mohammadi-Nasrabadi, et al |
Journal of Cleaner Production |
Public Health response| Interventions de santé publique Economics | Économie |
In this study, the association of socio-economic factors with food security and dietary diversity is assessed before
and during the COVID-19 pandemic. Data from 299 respondents were collected by an online standard questionnaire. Key socio-economic factors associated with food insecurity during the COVID-19 pandemic included personal savings, household income, employment
status of head of household, and nutrition knowledge of head of household. During the COVID-19 outbreak, household size, head of household’s occupation, personal savings, and number of male children were significantly associated with dietary diversity. |
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Pan, X, Xiao, et al |
Asia Pac Psychiatry |
Healthcare Response | Réponse des soins de santé |
This study aimed to investigate the current psychological status and associated risk factors among military healthcare
workers. The prevalence of depression, generalized anxiety, and somatic symptoms among military healthcare workers in specialized COVID‐19 hospitals is high during the current COVID‐19 outbreak. |
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Panda, S, Mohamed, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study endeavours to comprehensively the study the spectrum of ENT manifestations in mild and asymptomatic COVID-19
and observe the natural course of anosmia and dysgeusia consequent to SARS-Cov-2 infection. By the end of 4 weeks 96% of the patients had recovered completely. The incidence of anosmia and dysgeusia in this study parallels the rates reported from other Asian
countries, albeit, lower than the rates quoted from the Western Hemisphere. |
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Park, JH, Lee, et al |
American Journal of Emergency Medicine |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
This study aimed to describe the timely strategies used to prevent the spread of the emerging coronavirus disease 2019
(COVID-19) and present the activities performed in a regional base hospital in South Korea, from the identification of the index patient until the pandemic declaration. |
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Two fatal cases of stress-induced cardiomyopathy in COVID-19 patients |
Park, JH, Moon, et al |
Journal of Cardiovascular Imaging |
Clinical data| Données cliniques |
We present 2 fatal cases of stress-induced cardiomyopathy in COVID-19 patients requiring intensive care. |
|
Paternoster, G, Sartini, et al |
Medicina Intensiva |
Clinical data| Données cliniques |
Helmet continuous positive airway pressure (CPAP) during pronation was feasible and safe in COVID-19 acute respiratory
distress syndrome (ARDS) managed outside the ICU and sedation with dexmedetomidine safely improved comfort. We recorded an increase in PaO2/FIO2, SpO2 and a reduction in respiratory rate. |
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Patti, RK, Dalsania, et al |
Journal of Investigative Medicine High Impact Case Reports |
Clinical data| Données cliniques |
We report the case of a 73-year-old male who presented with progressive dyspnea; diagnosed with SARS-CoV-2–related
severe acute respiratory distress syndrome and complicated with lung cavitations growing Aspergillus sp. COVID-19, to our knowledge, has rarely been associated with subacute invasive pulmonary aspergillosis with aspergillomas. |
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Peng, X, Guo, et al |
Pediatr Radiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated the chest CT findings in children with COVID-19, and explored the differences in these findings between
symptomatic patients and asymptomatic patients. Symptomatic patients were mainly young children ≤3 years old (54/63, 86%),while asymptomatic patients were mainly children ≥ 6 years old (51/111, 46%). Fever (41%) and cough (41%) were the most common symptoms.
Overall, 119/201 (59%) patients had chest CT findings, and symptomatic patients accounted for 82% (98/119). The lung lesions of most patients were absorbed and improved in about 9 days. |
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Peralta, EA, Taveras, et al |
Indian Journal of Psychiatry |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
This study aims to determine the effectiveness of teleconsultation use to increase access to mental health services,
provided by volunteer staff during the quarantine of the COVID-19 pandemic in the Dominican Republic. The enablement of this teleconsultation model and the number of interventions made during this period of the COVID-19 pandemic, suggests that access to mental
healthcare in the Dominican Republic has increased. Problems with anxiety, sleep, and depression are common during the COVID-19 pandemic. Only a small group of patients have needed to be referred for face-to-face care, demonstrating that teleconsultation has
been an effective tool. |
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Pereira, MR, Aversa, et al |
American Journal of Transplantation |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
we evaluated the clinical characteristics and outcomes of 29 hospitalized SOT recipients who received tocilizumab for
severe COVID‐19, compared to a matched control group who did not. The 90‐day mortality was significantly higher among patients who received tocilizumab (41%) compared to those who did not (20%, P = .03). When compared to control patients matched by age, hypertension,
chronic kidney disease, and administration of high dose corticosteroids, there was no significant difference in mortality. |
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Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective
trial |
Perrone, F, Piccirillo, et al |
J Transl Med |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We present a multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, to study
the effect of tocilizumab on lethality rates at 14 and 30 days. Tocilizumab reduced lethality rate at 30 days compared with null hypothesis, without significant toxicity. Possibly, this effect could be limited to patients not requiring mechanical respiratory
support at baseline. |
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Pesel, G, Canals, et al |
International maritime health |
Public Health response| Interventions de santé publique |
The aim of the study was to evaluate the well- -being of the seafarers during the outbreak of COVID-19 pandemic and
their evaluation of the precautions taken by the shipping companies. The hypothesis that excess work-related stress has been put on the seafarers in this specific situation was confirmed and calls for prevention. |
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Peterson, ZD, Vaughan, et al |
Traumatology |
Public Health response| Interventions de santé publique |
We evaluated psychological reactions to the pandemic as a function of sexual identity. A convenience sample of 170
U.S. men and women (33% sexual minority) were recruited from online sources to complete a survey assessing experiences with COVID-19. Although there was evidence of substantial mental health difficulties throughout the entire sample, sexual minorities and
women reported more general psychological distress and more peritraumatic stress associated with the pandemic than sexual majorities and men, respectively. |
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Picon, RV, Carreno, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie |
We assess population-based prevalence, risk factors, hospitalization, and infection fatality rates (IFR) associated
with COVID-19 in Brazil. Summarized overall prevalence was 3.40% (95% CI, 2.74–4.18), 34% lower in older adults ≥60 years. IFR ranged from 0.08% (0.06–0.11) to 4.63% (2.93–7.84) in individuals 20–39 years and ≥60 years, respectively. |
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COVID-19 in Cancer Patients From New York City: A Comparative Single Center Retrospective
Analysis |
Ramachandran, P, Kathirvelu, et al |
Cancer Control |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective study we analyze and compare clinical characteristics and outcomes of patients with and without
cancer history who were infected with novel coronavirus disease 19 (COVID-19). Rapid clinical deterioration was seen in cancer patients who were aged 60 years and above. Higher mortality was seen in this subgroup, especially when they had associated hypertension
and elevated levels of CRP and LDH. |
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Lung Ultrasound to Predict Unfavorable Progress in Patients Hospitalized for
COVID-19 |
Ramos Hernández, C, Botana Rial, et al |
Archivos de Bronconeumologia |
Clinical data| Données cliniques |
The use of scores to quantify lung involvement measured by thoracic ultrasound provides useful information, facilitating
risk stratification in patients hospitalized with COVID-19. We included 44 patients, 13 (29,5%) of whom subsequently needed ventilatory support. Eight areas were explored in all patients and 14 areas in 35 (79.5%). |
|
Rashan, N, Bahmani, et al |
International Journal of High Risk Behaviors and Addiction |
Clinical data| Données cliniques |
The present study presents a 29-year-old female G1P0 at 33 weeks’ gestation. The patient’s initial complaint was the
premature rupture of membranes. The patient’s vital signs showed an abnormal pulse rate and temperature. A throat swab specimen was positive for COVID-19. A throat swab specimen was taken from the newborn for RT-PCR. Also, the mother’s chest CT scan was done
that showed abnormality; however, the RT-PCR throat swab specimen was negative for the newborn. |
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Rathinavel, T, Thangaswamy, et al |
Research Journal of Biotechnology |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In the present study, four ligand groups (I - IV) were made comprising of one commercial anti-viral drug group (14
Nos) and three ligands group (84 Nos) constituted from phytocompounds of three anti-viral Indian Traditional Medicinal plants (ITMP) such as Azadirachta indica, Phyllanthus niruri andrographis paniculata to search effective drug candidate for treating novel
coronavirus. In silico virtual screening analysis showed four best ligands Baloxavir marboxil (CID124081896), Limocinin (CID 14845550), Formononetin 7 O Glucuronide (CID 71316927) and Bisandrographolide A (CID12000062). One from each ligands group was considered
as best drug candidate for SARS CoV-2. |
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Reizer, A, Koslowsky, et al |
Health Care Women Int |
Public Health response| Interventions de santé publique |
The purpose of the present article is to examine the impact of this disturbing environment on Israeli women. Specifically,
we examined whether fear of the virus would impact the women’s distress symptoms, self-rated health (SRH), and marital satisfaction. A total of 130 Israeli married women with children completed the survey. The results indicated that fear of COVID-19 was negatively
associated with SRH as well as marital satisfaction, and positively associated with psychological distress. |
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Rewley, J |
Epidemiology |
Modelling/ prediction| Modélisation/prédiction Diagnostics / Pathogen detection| Diagnostics
/ Détection d'agents pathogènes |
To reflect potential clusters of cases that might queue at a testing site and that might increase the efficiency of
batch testing, I simulate 10,000 persons being tested in sequence. I use a prevalence ranging from 1% to 45% and batch sizes ranging from 3 to 25 and assume the increased probability of consecutive infections ranges from 0% to 45%. I find that as the likelihood
of clustered infections increases, the efficiency of specimen pooling increases. This analysis suggests that when clusters of infected persons exist at testing sites, specimen pooling can remain efficient even as prevalence increases. |
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Rieger, MO |
Frontiers in Sociology |
Public Health response| Interventions de santé publique |
In a survey among 250 subjects recruited at a German university and predominantly university students, we elicit opinions
about social distancing, i. e., the necessity to keep away from other people to slow down the speed of the ongoing SARS-CoV-2 epidemics. The good news is that most students are supportive to it. A certain degree of mistrust to media is widespread (around a
third of the subjects). To improve positive attitudes to social distancing and thus to improve compliance we recommend therefore to emphasize relations of persons to elderly people in health communications more. |
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Roberto, A, Sellon, et al |
Health Care Women Int |
Public Health response| Interventions de santé publique |
This study investigated the impact of spirituality on resilience during our current pandemic. A mixed-method approach
was used to analyze correlations between spirituality and resilience of women. Thematic analysis of six open-ended questions provide depth to quantitative findings supporting the positive influence of spirituality on resilience, hope, optimism, peace, and
comfort suggesting that spirituality may be an important dimension as this pandemic continues to unfold across the globe. |
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32967786; Conspiracy theories as barriers to controlling the spread of COVID-19
in the U.S |
Romer, D, Jamieson, et al |
Social Science and Medicine |
Public Health response| Interventions de santé publique |
We hypothesized that accepting conspiracy theories that were circulating in mainstream and social media early in the
COVID-19 pandemic in the US would be negatively related to the uptake of preventive behaviors and also of vaccination when a vaccine becomes available. Belief in COVID-related conspiracy theories predicts resistance to both preventive behaviors and future
vaccination for the virus, so it will be critical to confront both conspiracy theories and vaccination misinformation to prevent further spread of the virus in the US. |
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Human Hematopoietic Stem, Progenitor, and Immune Cells Respond Ex Vivo to SARS-CoV-2
Spike Protein |
Ropa, J, Cooper, et al |
Stem Cell Rev Rep |
Coronavirology| Coronavirologie Immunology | Immunologie |
We examined the expression of ACE2, to which SARS-CoV-2 Spike (S) protein binds to facilitate viral entry, in cord
blood derived HSCs/HPCs and in peripheral blood derived immune cell subtypes. |
|
Roxanne, L, Julia, et al |
Can J Psychiatry |
Public Health response| Interventions de santé publique |
Examine the association between the frequency of news media use during the COVID-19 pandemic and the extent of psychological
distress in pregnant women, considering the known deleterious impacts of this distress on fetal development. The more pregnant women consult the news media during the COVID-19 pandemic, the more prone they are to exhibit psychological distress. The results
offer one of the first empirical support for the recommendations of the World Health Organization, the Government of Canada and psychiatric associations encouraging the population to limit their consultation of the news media during the COVID-19 pandemic. |
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|
Russell, FM, Wang, et al |
American Journal of Emergency Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Our goal was to determine characteristics that identify patients at high risk for adverse outcomes who may need admission
to the hospital instead of an observation unit. Over 1/4 of suspected COVID-19 patients admitted to an ED observation unit ultimately required admission to the hospital. Risk factors associated with admission include hypoxia, bilateral infiltrates on chest
radiography, or the combination of these two factors plus either age > 48 years or Hispanic race. |
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Ryan, C, Minc, et al |
American Journal of Emergency Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We developed a risk-stratification model to predict severe Covid-19 related illness, using only presenting symptoms,
comorbidities and demographic data. Severe Covid-19 illness can be predicted using data that could be obtained from a remote screening. With validation, this model could possibly be used for remote triage to prioritize evaluation based on susceptibility to
severe disease while avoiding unnecessary waiting room exposure. |
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Sabri, B, Hartley, et al |
Health Care Women Int |
Public Health response| Interventions de santé publique |
We explored the perspectives of service providers (n = 17) and immigrant survivors of intimate partner violence (IPV)
(n = 45) on the impact of COVID-19 on immigrant women, existing services for survivors and strategies needed needed to enhance women’s health and safety. |
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Saez-Giménez, B, Berastegui, et al |
Am J Transplant |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study describes the clinical presentation, treatment, and outcomes of SARS‐CoV‐2 infection in lung transplant
recipients (LTRs). This is a multicenter, retrospective study of all adult LTRs with confirmed SARS‐CoV‐2 infection from March 4th until April 28th, 2020 in six Spanish reference hospitals. Forty‐four cases were identified in that period. The median time from
transplantation was 4.2 (interquartile range: 1.11–7.3) years. SARS‐Cov‐2 presented with high mortality. Additionally, the severity of disease on presentation predicted subsequent mortality. |
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Sakamoto, A, Kawakami, et al |
Arterioscler Thromb Vasc Biol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To understand which cells in the heart are the most likely targets for infection, immunostaining for ACE2 and TMPRSS2,
real-time polymerase chain reaction, and in-situ hybridization (ISH) of hearts from 15 COVID-19 victims from Bergamo, Italy was conducted. Control normal hearts, dilated cardiomyopathy, and viral myocarditis hearts (non-COVID-19) were selected from CVPath
registry. Combined with our findings, even in the presence of SARS-CoV-2 in the heart, our data as well as that of others suggest viral myocarditis is quite rare and likely not a major cause of myocardial injury. |
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Sakanashi, D, Asai, et al |
Journal of Infection and Chemotherapy |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we investigated suitability of saliva as a non-invasively obtained specimen for molecular detection of SARS-CoV-2
RNA in Japanese patients with COVID-19. In total, 28 paired clinical specimens of saliva and nasopharyngeal swabs were collected from 12 patients at various time points after symptom onset. The saliva and nasopharyngeal swab specimens showed 19 and 15 positive
results, respectively. Three convalescent patients presented saliva-positive results, whereas their nasopharyngeal swabs were negative at four different time points, suggesting that saliva may be superior to nasopharyngeal swabs in terms of obtaining stable
assay result of SARS-CoV-2. |
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Salah, M, Belghiti, et al |
Journal of Molecular Graphics and Modelling |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The molecular electronic density theory (MEDT) was invested to elucidate the chemo-, regio- and stereo-selectivity
of the 1,3-dipolar cycloaddition between Diazomethane (DZM) and Psilostachyin (PSH). We investigate about the potential of inhibition of some pyrazoline compounds against COVID-19-Mpro by performing a molecular docking calculations. |
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Salman, M, Asif, et al |
Disaster Med Public Health Prep |
Public Health response| Interventions de santé publique |
This web-based, cross-sectional study was conducted among university students from Pakistan to investigate the psychological
impairment and coping strategies during COVID-19 pandemic. COVID-19 cause significant impairment on mental health of the students. The most frequent coping strategy adopted by students were religious/spiritual and acceptance coping. During epidemics mental
health of students should not be neglected. |
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Impact of the perceived risk from Covid-19 on intention to travel |
Sánchez-Cañizares, SM, Cabeza-Ramírez, et al |
Current Issues in Tourism |
Public Health response| Interventions de santé publique |
The objective of this study is to analyse the impact of perceived risk on intention to travel in the Covid-19 pandemic
situation. |
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COVID-19: What Iodine Maps From Perfusion CT can reveal-A Prospective Cohort Study |
Santamarina, MG, Boisier Riscal, et al |
Crit Care |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Assess lung perfusion changes with sCTA seen in patients with COVID-19 pneumonia and correlate them with clinical outcomes.The
main common patterns seen in lung CT scans were ground-glass opacities, mixed pattern with predominant ground-glass opacities and mixed pattern with predominant consolidation in 56.1%, 24.4% and 19.5% respectively. Perfusion abnormalities were common (36 patients,
87.8%), mainly hypoperfusion in areas of apparently healthy lung. Patients with severe hypoperfusion in areas of apparently healthy lung parenchyma had an increased probability of being admitted to ICU and to initiate IMV (HR of 11.9 (95% CI 1.55–91.9) and
HR 7.8 (95% CI 1.05–61.1), respectively).Perfusion abnormalities evidenced in iodine maps obtained by sCTA are associated with increased admission to ICU and initiation of IMV in COVID-19 patients. |
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Sarmadi, M, Moghanddam, et al |
Air Quality, Atmosphere and Health |
Epidemiology| Épidémiologie |
This ecological study investigated the association between COVID-19 distribution and air quality index (AQI), comorbidities
and sociodemographic factors in the USA. The AQI factors included in the study are total AQI, ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide (NO2). Other demographic, socioeconomic, and geographic variables were included as covariates. The correlations
of COVID-19 variables—proportion of cases and deaths in each population, as well as case fatality rate with independent variables were determined by Pearson and Spearman correlation and multiple linear regression analyses. The results revealed that AQI-NO2,
population density, longitude, gross domestic product per capita, median age, total death of disease, and pneumonia per population were significantly associated with the COVID-19 variables (P < 0.05). Air pollutants, especially NO2 in the US case, could be
addressed as an important factor linked with COVID-19 susceptibility and mortality. |
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Dynamics of SARS-CoV-2 transmission among Indian nationals evacuated from Iran |
Saurabh, S, Kumar, et al |
Disaster Med Public Health Prep |
Epidemiology| Épidémiologie Transmission |
Indian nationals evacuated from Iran were quarantined at Jaisalmer, Rajasthan, COVID-19 infection transmission within
this closed population was studied. Forty-eight SARS-CoV-2 infections were found among the 474 quarantined individuals. Out of them, 44 (92%) were asymptomatic. R0 for the overall duration was found to be 2.29 (95% CI 1.84 – 2.78). Male gender and age ≥ 60
years were associated with SARS-CoV-2 infection (RR = 4.33, 95% CI 2.07 – 9.05 and 5.32, 95% CI 3.13 – 9.04, respectively). Isolation of infected individuals and stricter quarantine of remaining individuals reduced the R0 from 2.41 initially to 1.17 subsequently. |
|
Schlichtiger, J, Brunner, et al |
J Investig Med |
Public Health response| Interventions de santé publique |
Present study aimed to explore psychological effects of the COVID-19 crisis on a sample of Bavarian students. Analysis
identified sex and the level of physical activity as potential risk factors for the level of mental stress during the COVID-19 pandemic. |
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Schneider, MB, Greif, et al |
Training and Education in Professional Psychology |
Healthcare Response | Réponse des soins de santé |
The present study used a mixed methods approach to examine mental health symptoms, perceived safety, and ongoing and
desired support among a national sample of psychology interns, psychology intern and postdoctoral trainees during the COVID-19 pandemic. Participants reported clinically elevated anxiety and depressive symptoms. Participants working on-site who felt that their
health or safety was at risk reported more anxiety symptoms. Most common workplace safety concerns included inadequate protection against risk and face-to-face patient care requirements. |
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Seaton, RA, Gibbons, et al |
Journal of Infection |
Healthcare Response | Réponse des soins de santé |
Results from a point prevalence survey of prescribing was conducted across acute hospitals in Scotland, following national
antibiotic recommendations for suspected bacterial respiratory tract infection complicating COVID-19. Antibiotics were prescribed in 38% SARS-CoV-2 patients in wards and critical care units. Narrow spectrum antibiotics were predominant in wards reflecting
national recommendations. Broad spectrum antibiotics and antifungals in critical care indicative of suspected nosocomial bacterial and fungal infections. Lower odds of antibiotic associated with nosocomial COVID-19, diabetes and in elderly care. |
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Online
health information utilization and online news exposure as predictor of COVID-19 anxiety |
Shabahang, R, Aruguete, et al |
North American Journal of Psychology |
Public Health response| Interventions de santé publique |
The purpose of this study was to explore whether online health information utilization and exposure to COVID-19 Internet
news predict COVID-19 anxiety. A convenience sample of 427 Iranian college students completed the COVID-19 Anxiety Questionnaire and Online Health Information Utilization Questionnaire. Participants were also asked to rate their online news usage related to
COVID-19. Pearson correlation and multiple regression analyses revealed that online health information utilization and COVID-19 Internet news usage significantly predicted COVID-19 anxiety. Greater frequency of Internet news use and online health information
about COVID-19 was linked to higher anxiety levels. These findings suggest that the Internet plays a remarkable role in COVID-19 anxiety. |
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Shakir, SM, Barker, et al |
J Clin Microbiol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Performed a prospective study of self-collected oropharyngeal swab (OPS) combined with self-collected swabs versus
HCP-collected nasopharyngeal |
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Sharma, R, Saxena, et al |
Indian Journal of Anaesthesia |
Healthcare Response | Réponse des soins de santé |
he current study was designed primarily to outline the prevalence of depression, anxiety, and stress among the HCWs
and administrative staff. The secondary outcome was to compare depression, anxiety, stress score (DASS) between the first-line and the second-line HCWs and other common factors associated with increased DASS scores. All the HCWs working in our tertiary care
unit were encouraged to participate in the study. Among the administrative staff (total 50); 9/50 (18%) were anxious, 4/50 (8%) were stressed, and 11/50 (22.0%) were depressed when compared to HCWs demonstrating a significantly higher prevalence of anxiety:
85/150 (56.7%), stress: 82/150 (54.7%), and depression. |
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Sharma, R, Sharma, et al |
Indian Journal of Psychiatry |
Public Health response| Interventions de santé publique |
The total number of cases enrolled in the study was 204 (Kathmandu, Nepal); 62.2% were male and 32.8% were female and
the mean age was 32.03 years. Twenty-three percent (23.5%) had preexisting health conditions. Out of the 204 participants, 67.6% said they were stressed following the lockdown and the mean rated stress was 2.90 in a scale ranging from 1 to 7. The frequently
identified stressors were fear of contamination, restricted movement, and for inadequate supplies. Twenty-seven percent said they had some psychological symptoms and the most common symptoms were palpitation and sleep disturbance. Seventy-three individuals
(36.5%) were found to have psychiatric problem according to their scores in General Health Questions (GHQ). Rated stress and GHQ-12 scores were strongly correlated. |
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Sharma, S, Keswani, et al |
Annals of the Academy of Medicine, Singapore |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Described experience in treating early COVID-19 cases in India. An observational study of COVID-19 patients admitted
to a tertiary care centre in North India between 2 March-4 April 2020 was performed. The clinical, epidemiological, laboratory, treatment and outcome data of patients were evaluated. RESULTS: A total of 75 patients were treated and 56 (74.66%) were men. The
clinical spectrum of COVID-19 ranged from asymptomatic to acute respiratory distress syndrome (ARDS). Fever (85.36%) was the most common symptom followed by cough (56.09%) and dyspnoea (19.51%). Findings from hemogram analysis showed that 32%, 21.33% and 18.67%
of patients had lymphopaenia, eosinopenia and thrombocytopaenia, respectively. Inflammatory markers such as C-reactive protein, D-dimer, ferritin, fibrin degradation product and interleukin-6 were significantly elevated (P <0.05) in patients who required oxygen
therapy than those who did not require it, suggesting the potential role such markers could play in predicting prognosis in patients. Mean hospital stay was 9.2 days and 72 (96%) patients made a complete recovery, but 3 (4%) patients demised after progressing
to ARDS. |
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Shikov, AE, Barbitoff, et al |
Frontiers in Genetics |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Analyzed a large publicly available dataset, the Genome Aggregation Database (gnomAD), as well as a cohort of 37 Russian
patients with COVID-19 to assess the influence of different classes of genetic variants in the angiotensin-converting enzyme-2 (ACE2) gene on the susceptibility to COVID-19 and the severity of disease. Southern European population has a lower frequency of
missense variants and slightly higher frequency of regulatory variants. However, we found no statistical support for the significance of these differences. We also show that the Russian population is similar to other European populations when comparing the
frequencies of the ACE2 variants. Evaluation of the effect of various classes of ACE2 variants on COVID-19 outcome in a cohort of Russian patients showed that common missense and regulatory variants do not explain the differences in disease severity. |
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Shui, J, Yue, et al |
Chinese Journal of Endocrinology and Metabolism |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Explore the relationship between diabetes mellitus targets and ACE2 of the receptor of novel coronavirus(2019-nCoV)
through a protein interaction network to provide new perspectives for clinical use. 19 ACE2-related proteins were finally selected from diabetes mellitus targets. Three functional modules were found through the cluster analysis. These modules involved G protein-coupled
receptor binding, antioxidant activity, and insulin-like growth factor receptor binding. The main signal pathways involved were the renin angiotensin system signal pathway, the type 2 diabetes mellitus signal pathway, and the FOXA2 signal pathway. The scoring
results showed that REN, AGT, INS, NOS3, IL6, and CRP scored the highest. ACE2 is widely associated with diabetes mellitus key proteins. COVID-19 may impact RAS of diabetes mellitus patients then induce serious complications. Clinical use of RAS inhibitors
may reduce the impact of COVID-19 infection on diabetes mellitus patients. |
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Silva, L, Figueiredo Filho, et al |
Cad Saude Publica |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Conducted an interrupted time series analysis to estimate the impact of lockdowns on reducing the number of cases and
deaths due to COVID-19 in Brazil. Official daily data was collected for four city capitals before and after their respective policies interventions based on a 14 days observation window. A segmented linear regression to evaluate the effectiveness of lockdown
measures on COVID-19 incidence and mortality was estimated. The initial number of new cases and new deaths had a positive trend prior to policy change. After lockdown, a statistically significant decrease in new confirmed cases was found in all state capitals.
We also found evidence that lockdown measures were likely to reverse the trend of new daily deaths due to COVID-19 |
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Simonsen, AB, Ruge, et al |
Contact dermatitis |
Public Health response| Interventions de santé publique |
OBJECTIVES: To examine the occurrence and point prevalence of hand eczema as a consequence of more intensive hand hygiene
among Danish children attending daycare. METHODS: The heads of 1,667 daycare centers in Denmark were contacted and asked to forward a link to a questionnaire to parents of the children attending the daycare center. RESULTS: Among 6858 children, 12.1% suffered
from hand eczema before reopening of daycare centers, whereas 38.3% reported hand eczema after the children returned to daycare. Of the children who never suffered from hand eczema, 28.6% developed hand eczema after returning to daycare. The risk of hand eczema
was significantly associated with atopic dermatitis, female gender, higher age, and frequency of handwashing. |
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Sims, JT, Krishnan, et al |
Journal of Allergy and Clinical Immunology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Identify and characterize the host inflammatory response to severe acute respiratory syndrome coronavirus 2 infection,
by assessed levels of proteins related to immune responses and cardiovascular disease in patients stratified as mild, moderate, and severe versus matched healthy controls. Results indicate a dominant hyperinflammatory milieu in the circulation and vascular
endothelial damage markers within patients with COVID-19, and strong biomarker association with patient response as measured by Ordinal Scale. As patients progress, we observe statistically significant dysregulation of IFN-γ, IL-1RA, IL-6, IL-10, IL-19, monocyte
chemoattractant protein (MCP)-1, MCP-2, MCP-3, CXCL9, CXCL10, CXCL5, ENRAGE, and poly (ADP-ribose) polymerase 1. Furthermore, in a limited series of patients who were sampled frequently, confirming reliability and reproducibility of our assays, we demonstrate
that intervention with baricitinib attenuates these circulating biomarkers associated with the cytokine storm. |
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Singh, S, Nourozi, et al |
Journal of Nutritional Science |
Public Health response| Interventions de santé publique |
The study finds substantial increase in food commodity prices across food groups and districts with marked inter-district
variation. For school meal basket, all micronutrients show large average declines ranging from 9.5% for zinc to 11% for vitamin A. For household food baskets on average, vitamin-A reduced 37% followed by iron at 19%, reduction in zinc is low due to the high
zinc content in whole grain cereals. COVID-19 control measures are likely to have contributed to substantial price inflation over the reference period with potentially damaging effects on nutrition security in Nepal with serious implications for vulnerable
populations |
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Sonnweber, T, Boehm, et al |
Respir Res |
Epidemiology| Épidémiologie Clinical data| Données cliniques RCT |
Present data from the ongoing prospective, multicentre, observational CovILD cohort study (ClinicalTrials.gov number,
NCT04416100), which systematically follows up patients after COVID-19. 109 participants were evaluated 60 days after onset of first COVID-19 symptoms including clinical examination, chest computed tomography and laboratory testing. 60 days after disease onset,
30% of subjects still presented with iron deficiency and 9% had anemia, mostly categorized as anemia of inflammation. Anemic patients had increased levels of inflammation markers such as interleukin-6 and C-reactive protein and survived a more severe course
of COVID-19. Hyperferritinemia was still present in 38% of all individuals and was more frequent in subjects with preceding severe or critical COVID-19. Analysis of the mRNA expression of peripheral blood mononuclear cells demonstrated a correlation of increased
ferritin and cytokine mRNA expression in these patients. Finally, persisting hyperferritinemia was significantly associated with severe lung pathologies in computed tomography scans and a decreased performance status as compared to patients without hyperferritinemia. |
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Stress and stigmatization in health-care workers during the COVID-19
pandemic |
Sorokin, MY, Kasyanov, et al |
Indian Journal of Psychiatry |
Healthcare Response | Réponse des soins de santé |
This study aimed to evaluate the structure and severity of psychological distress and stigmatization in different categories
of health-care workers during the COVID-19 pandemic. The psychological stress levels decreased in the second phase, while the stigma levels increased. Physicians experienced more stress compared with nurses and paramedical personnel, but were less likely to
stigmatize SARS-CoV-2-infected individuals. The increasing probability of contact with infected individuals was associated with higher levels of psychological stress (probable contact ES = 0.48; definite contact ES=0.97). The highest rates of contacts with
COVID-19 patients were reported by physicians, the youngest, and less experienced medical workers. |
|
Stevenson, JM, Alexander, et al |
Clin Transl Sci |
Epidemiology| Épidémiologie Therapeutics| Thérapeutique |
A cross‐sectional analysis of electronic health records from consecutive individuals hospitalized with COVID‐19 at
a large, urban academic health system. Characterized medication orders, focusing on medications with actionable pharmacogenomic guidance related to 14 commonly‐assayed genes (CYP2C19, CYP2C9, CYP2D6, CYP3A5, DPYD, G6PD, HLA‐A, HLA‐B, IFNL3, NUDT15, SLCO1B1,
TPMT, UGT1A1, VKORC1). A simulation analysis combined medication data with population phenotype frequencies to estimate how many treatment modifications would be enabled if multi‐gene pharmacogenomic results were available. Sixty‐four unique medications with
pharmacogenomic guidance were ordered at least once in the cohort (n=1852, mean age 60.1 years). Nearly nine in ten individuals (89.7%) had at least one order for a medication with pharmacogenomic guidance and 427 patients (23.1%) had orders for 4 or more
actionable medications. The genes CYP2D6 and CYP2C19 were responsible for the majority of treatment modifications, and the medications most often affected were ondansetron, oxycodone, and clopidogrel. |
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Efficacy of Tocilizumab in Patients Hospitalized with Covid-19 |
Stone, JH, Frigault, et al |
N Engl J Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique
RCT |
Performed a randomized, double-blind, placebo-controlled trial involving patients with confirmed severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, hyperinflammatory states, and at least two of the following signs: fever (body temperature >38°C), pulmonary infiltrates, or the need for supplemental oxygen in order to maintain an oxygen saturation greater than
92%. Patients were randomly assigned in a 2:1 ratio to receive standard care plus a single dose of either tocilizumab (8 mg per kilogram of body weight) or placebo. Tocilizumab was not effective for preventing intubation or death in moderately ill hospitalized
patients with Covid-19. Some benefit or harm cannot be ruled out, however, because the confidence intervals for efficacy comparisons were wide. |
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Features of minor depressive disorder subtypes in conditions of
COVID-19 pandemic |
Sultanov, S, Khodzhaeva, et al |
Indian Journal of Psychiatry |
Public Health response| Interventions de santé publique |
Background: The continuous research on minor depressive disorder is one of the pressing issues in the context of the
COVID-19 pandemic. We studied the features of minor depressive disorder subtypes in conditions of the COVID-19 pandemic. Materials and Methods: Sixty-two patients were observed with the administration of clinical follow-up research method. Results: The following
major subtypes of minor depressive disorder were identified: Asthenic, hysterical, hypochondriacal, apathetic, and minor depressive disorder with obsessive-compulsive symptoms. Conclusions: The COVID-19 pandemic lead to an increase in the development of the
minor depressive disorder with a predominance of asthenic and obsessive-phobic symptoms. |
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Study on glycemic profiles and emotional scales in diabetic patients
after the outbreak of COVID-19 |
Sun, X, Shi, et al |
Chinese Journal of Endocrinology and Metabolism |
Epidemiology| Épidémiologie Clinical data| Données cliniques Public Health response|
Interventions de santé publique |
Observe the glycemic profiles and emotion management in diabetic patients after the outbreak of novel coronavirus disease
2019(COVID-19) by a questionnaire survey. After the outbreak of COVID-19, there was an increasing trend in blood glucose, but there was no statistical difference. Body weight, lipids profiles were not different in diabetic patients, either. Most of diabetic
patients had mild symptoms of anxiety, depression and sleep disorders. Very few patients presented moderate to severe symptoms of anxiety, depression and sleep disorders. |
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Restriction of SARS-CoV-2 Replication by Targeting
Programmed −1 Ribosomal Frameshifting In Vitro |
Sun, Yu, Abriola, et al |
bioRxiv |
Therapeutics| Thérapeutique |
Translation of open reading frame 1b (ORF1b) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires
programmed −1 ribosomal frameshifting (−1 PRF) promoted by an RNA pseudoknot. The extent to which SARS-CoV-2 replication may be sensitive to changes in −1 PRF efficiency is currently unknown. Through an unbiased, reporter-based high-throughput compound screen,
we identified merafloxacin, a fluoroquinolone antibacterial, as a −1 PRF inhibitor of SARS-CoV-2. Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on −1 PRF of other beta coronaviruses. Importantly,
frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting −1 PRF as an effective antiviral strategy for SARS-CoV-2. |
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Surabotsophon, M, Klai-On, et al |
Clinical Case Reports |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Three patients diagnosed with severe COVID-19 pneumonia received treatment with hydroxychloroquine combined with lopinavir,
ritonavir, and favipiravir. Two patients diagnosed early, received tocilizumab when the pneumonia became severe and survived. The thrid patient was diagnosed late and received tocilizumab when the disease progressed to acute respiratory distress syndrome,
and died. |
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Szabolcs, M, Sauter, et al |
Appl Immunohistochem Mol Morphol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We studied the suitability of commercially available monoclonal antibodies (mAbs) for the immunohistochemical (IHC)
detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in standard archival specimens. Antibodies were screened on HEK293 cells transfected with viral nucleoprotein, S1 subunit and S2 subunit of spike protein and on untransfected cells, as
well as a panel of normal tissue. Lung tissue with presence of SARS-CoV2 confirmed by in situ hybridization (ISH) was also used. |
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Tam, CC, Sun, et al |
AIDS Behav |
Healthcare Response | Réponse des soins de santé |
This study examined organizational and intrapersonal factors contributing to psychological health during COVID-19 pandemic.
Data were collected via online anonymous surveys from 1029 HIV healthcare providers in Guangxi, China during April-May 2020. Path analysis was utilized to test a mediation model among COVID-19 stressors, institutional support, resilience, and psychological
distress (PHQ-4). Thirty-eight percent of the providers experienced psychological distress (PHQ-4 score > 3). Institutional support and resilience mediated the relationship between COVID-19 stressors and psychological distress. |
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Correlation between serum calcium levels and disease severity in patients
with COVID-19 |
Tang, S, Deng, et al |
Chinese Journal of Endocrinology and Metabolism |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Investigate the correlation between serum calcium levels and severity of novel coronavirus pneumonia(COVID-19), among
COVID-19 patients diagnosed from January to February 2020 (n=165). Compared with the control group, the age, diabetes, basic respiratory disease, and cardiovascular disease ratio, C-reactive protein(CRP), fasting blood glucose(FPG), interferon γ(IFN-γ), and
interleukin 17(IL-17) levels increased while the lymphocyte percentage, serum albumin(ALB), corrected calcium levels, CD4+ T cells percentage, CD8+ T cell percentage decreased, the difference was statistically significant(P<0.05). There was no significant
statistical difference in gender between the two groups, hypertension ratio, alanine aminotransferase(ALT), glomerular filtration rate(eGFR), CD4+/CD8+ ratio and interleukin 4(IL-4) levels(P>0.05). The decrease of calcium level, age and eGFR were all risk
factors for COVID-19 patients. Compared with the normal calcium group of COVID-19 patients, the level of ALB, CD4+ T cells percentage, CD8+ T cell percentage in low calcium group decreased and age, proportion of critically ill patients, diabetes, basic respiratory
disease and cardiovascular disease ratio and CRP level all increased. |
|
Telles-Garcia, N, Zahrli, et al |
Case Reports in Psychiatry |
Clinical data| Données cliniques |
Report a case from the United States describing a young male with a suicidal attempt who was subsequently found to
have COVID-19 infection. |
|
|
Thombs, BD, Kwakkenbos, et al |
Journal of psychosomatic research |
Public Health response| Interventions de santé publique |
Compare anxiety and depression symptoms among people with a pre-existing medical condition and factors associated with
changes. Anxiety symptoms, but not depression symptoms, increased dramatically during COVID-19 among people with a pre-existing medical condition. |
|
|
Tian, Y, Tu, et al |
American Journal of Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
Investigate whether the use of N95 mask affects rescuer's fatigue and chest compression quality during cardiopulmonary
resuscitation (CPR). Significantly lower mean chest compression rate and depth were both achieved in the N95 group than in the SM group (p < 0.05, respectively). In addition, the proportion of correct compression rate (61 ± 19 vs. 75 ± 195, p = 0.0067), depth
(67 ± 16 vs. 90 ± 14, p < 0.0001) and complete recoil (91 ± 16 vs. 98 ± 5%, p = 0.0248) were significantly decreased in the N95 group as compared to the SM group. At the end of compression, the Borg score in the N95 group was significantly higher than that
in the SM group (p = 0.027). Wearing a N95 mask increases rescuer's fatigue and decreases chest compression quality during CPR. Therefore, the exchange of rescuers during CPR should be more frequent than that recommended in current guidelines when N95 masks
are applied. |
|
|
Torrente-Rodríguez, RM, Lukas, et al |
Matter |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The SARS-CoV-2 RapidPlex has the potential to quickly and effectively triage patients and track infection progression,
allowing for the clear identification of individuals who are infectious, vulnerable, and/or immune. The SARS-CoV-2 RapidPlex is developed on the basis of laser-engraved graphene immunosensors to electrochemically quantify SARS-CoV-2 nucleocapsid protein, IgG
and IgM, and C-reactive protein (CRP). The platform is characterized by rapid detection and high molecular sensitivity and selectivity. Pilot study results demonstrate that it can successfully detect these biomarkers in COVID-19-positive patient serum and
saliva samples. CRP results are well correlated with symptom severity, indicating the potential for this integrated system to be used as a diagnostic tool for telemedicine COVID-19 patient care. |
|
|
Exploring casual COVID-19 data visualizations on Twitter: Topics and challenges |
Trajkova, M, Alhakamy, et al |
Informatics |
Public Health response| Interventions de santé publique |
Conducted a Twitter crawl of 5409 visualizations (from the period between 14 April 2020 and 9 May 2020) to capture
what people are posting, what they retweet the most, and the challenges that may arise when interpreting COVID-19 data visualization on Twitter. Multiple factors, such as the source of the data, who created the chart (individual vs. organization), the type
of visualization, and the variables on the chart influence the retweet count of the original post. Identify and discuss five challenges that arise when interpreting these casual data visualizations, and discuss recommendations that should be considered by
Twitter users while designing COVID-19 data visualizations to facilitate data interpretation and to avoid the spread of misconceptions and confusion. |
|
Did the COVID-19 Pandemic Cause a Delay in the Diagnosis of Acute Appendicitis? |
Turanli, S, Kiziltan, et al |
World J Surg |
Healthcare Response | Réponse des soins de santé |
This study aims to assess the clinical presentation and delays in diagnosing acute appendicitis during the COVID-19
pandemic. We did not observe any clear increase in the diagnosis of perforated appendicitis during the pandemic period, even in patients who were transferred from other hospitals. |
|
Effectiveness of Face Masks in Preventing Airborne Transmission of SARS-CoV-2 |
Ueki, H, Furusawa, et al |
mSphere |
Transmission Infection Prevention and Control/ Prévention et contrôle des infections
(IPAC/PCI) Healthcare Response | Réponse des soins de santé |
Here, we developed an airborne transmission simulator of infectious SARS-CoV-2-containing droplets/aerosols produced
by human respiration and coughs and assessed the transmissibility of the infectious droplets/aerosols and the ability of various types of face masks to block the transmission. We found that cotton masks, surgical masks, and N95 masks all have a protective
effect with respect to the transmission of infective droplets/aerosols of SARS-CoV-2 and that the protective efficiency was higher when masks were worn by a virus spreader. Importantly, medical masks (surgical masks and even N95 masks) were not able to completely
block the transmission of virus droplets/aerosols even when completely sealed. |
|
Ugbolue, UC, Duclos, et al |
J Clin Med |
Public Health response| Interventions de santé publique |
The purpose of this study was to assess and report the impact of isolation and effect of coronavirus on selected psychological
correlates associated with emotions. The Wilcoxon signed rank test showed significant differences with respect to "Prior" COVID-19 and "Currently" for sedentary activity for "Prior"; and poor correlations (r) between leisure, physical activity and sedentary
action for "Current". The correlations (r) between sedentary action and emotion for "Prior" and "Currently" were and respectively. |
|
|
PMC7505131; Encephalopathy in COVID-19 patients; viral, parainfectious, or both? |
Umapathi, T, Quek, et al |
eNeurologicalSci |
Clinical data| Données cliniques |
We describe the clinical, laboratory and radiological features of 3 critically ill patients with COVID-19 who developed
severe encephalopathy. Patient 1 responded partially to empirical, albeit delayed, therapy with intravenous immunoglobulins. Patient 2 recovered with no specific treatment. The third patient remained in persistent, severe agitated delirium and died 3 months
into his illness. |
|
COVID-19 policy responses: reflections on governmental financial resilience in
South Asia |
Upadhaya, B, Wijethilake, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Economics | Économie |
First, the paper examines the short-term fiscal and budgetary responses of the South Asian governments to the COVID-19
pandemic. Next, it brings out the implications of such responses, focusing on India, Nepal and Sri Lanka. South Asian governments' response to the pandemic shows a gap in understanding the magnitude of the problem and in developing financial resilience. This
paper points out the importance of avoiding austerity, becoming more cautious in accepting lending conditions, rethinking public sector accountability and revitalising mutual collaboration through SAARC for developing financial resilience, both at individual
country and regional levels. |
|
GIS-based spatial modelling of COVID-19 death incidence in São Paulo, Brazil |
Urban, RC, Nakada, et al |
Environment and Urbanization |
Epidemiology| Épidémiologie |
Seeking to understand the socio-spatial behaviour of the COVID-19 virus in the most impacted area in Brazil, five spatial
regression models were analysed to assess the disease distribution in the affected territory. Results obtained using the Spearman correlation test provided evidence for the correlation between COVID-19 death incidence and social aspects such as population
density, average people per household, and informal urban settlements. More importantly, all analysed models using four selected explanatory variables have proven to represent at least 85 per cent of reported deaths at the district level. |
|
Vasiljeva, M, Neskorodieva, et al |
Journal of Open Innovation: Technology, Market, and Complexity |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Economics
| Économie |
The paper seeks to develop a predictive model for assessing the impact of the (COVID-19) pandemic on the economies
of Eastern Europe, taking into account quarantine measures. The number of infected people and the rate of infection were predicted for each of the Eastern European countries. The predicted decline in Eastern European GDP due to COVID-19 has been estimated
based on the construction of a prognostic regression model. |
|
|
Adverse
effects of lopinavir/ritonavir in critically ill patients with COVID-19 |
Vecchio, G, Zapico, et al |
Medicina (Argentina) |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We conducted an observational, retrospective, single-center study involving adult patients with severe SARS-CoV-2 infection.
We describe type and severity of the adverse events and if treatment suspension was needed. The results show a high rate of adverse events (10/23, 43%) in treatment with lopinavir/ritonavir. |
|
Cardiovascular admissions in intensive care units during COVID-19 pandemic |
Vensentini, N, Zaidel, et al |
Medicina (Argentina) |
Healthcare Response | Réponse des soins de santé |
The COVID-19 pandemic has led to measures of social isolation, labor restrictions, a strong information campaign and
the suspension of scheduled medical activities. The aim of this study was to describe the impact of these measures on the number of hospitalizations in Cardiovascular Intensive Care Units, with the hypothesis that the social behavior generated by this emergency
promotes a decreased demand for medical care, even when severe cardiovascular disease is involved. The average number of patient admissions on March-April 2010-19 was 595 and decreased to 348 in 2020. |
|
Impact analysis of temperature data on the increase in the count of infected cases
of COVID 19 |
Verma, P, Dumka, et al |
International Journal of Business Analytics |
Epidemiology| Épidémiologie |
This paper takes the study of specific areas around the world and also the case study of India to study the effect
of temperature on the rise of and death due to COVID-19 virus. The findings of the result states that temperature is having minor effect on the spread and rise of COVID-19. |
|
Vijayakumar, DS, Sneha, et al |
Alexandria Engineering Journal |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
With the avail of Deep learning approaches, cough is processed to understand the distinctions between the conventional
and covid cough. We have extracted some of the recordings from the public platforms and performed deep learning predicated analysis. This gave us the prognostication precision of 94% thus authoritatively mandating a better cough dataset to further carry out
the research at a more immensely colossal scale. This paper accommodates as a baseline to cerebrate beyond the customary clinical diagnosis and identify the disease at least in the preliminary in fraction of seconds thus requiring the buildup of covid cough
data. |
|
|
Von Kohorn, I, Stein, et al |
J Pediatric Infect Dis Soc |
Transmission Clinical data| Données cliniques |
Evidence for in utero transmission of SARS-CoV-2 is growing but not definitive. We present a case of neonatal infection
that supports in utero transmission of SARS-CoV-2 and provides insight into hematogenous spread from mother to fetus. The infant continued to be asymptomatic with normal laboratory studies but NP swabs tested positive for SARS-CoV-2 RNA. |
|
|
Vouga, Manon, Favre, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
Pregnant women at any stage during gestation tested for SARS-CoV-2 infection were enrolled. Maternal, obstetrical and
neonatal outcomes were recorded. 1033 pregnant women tested for SARS-CoV-2 were included, among which 926 tested positive and 107 tested negative. Pregnant women, particularly those with associated comorbidities, seem to be at higher risk of severe complications
of SARS-CoV-2 infection. A positive neonatal SARS-CoV-2 test was observed in 2.9% (n=11/384) of newborns. |
|
|
33000119; Cross-reaction of Sera from COVID-19 Patients with
SARS-CoV Assays |
Wan, WY, Lim, et al |
Annals of the Academy of Medicine, Singapore |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
We evaluated SARS-CoV test assays to detect for the presence of antibodies to SARS-CoV-2 and tried to determine the
timing of appearance of these antibodies by testing serial sera from these patients. Cross-reactivity was seen in these two test assays with sera from COVID-19 patients and was detected in 6 out of 7 patients from 7 days after onset of symptoms. Five of the
patients had detectable antibodies by the 3rd week into their illness and there was evidence of seroconversion in 4 patients. The IIFA method was marginally more sensitive compared to the ELISA assay, however the IIFA IgM test was not useful in the early phase
of the illness with poor sensitivity. |
|
Airborne particulate matter, population mobility and COVID-19: a multi-city study
in China |
Wang, B, Liu, et al |
BMC Public Health |
Epidemiology| Épidémiologie |
This study aims to examine the effects of airborne particulate matter (PM) pollution and population mobility on COVID-19
across China. We found each 1 unit increase in daily population mobility scale index was significantly positively associated with daily confirmed cases of COVID-19. In PM analysis, we found each 10 μg/m(3) increase in the concentration of PM(10) and PM(2.5)
was positively associated with the confirmed cases of COVID-19. |
|
A descriptive study of random forest algorithm for predicting COVID-19 patients outcome |
Wang, J, Yu, et al |
PeerJ |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A random forest algorithm was used to predict the prognoses of COVID-19 patients in Wuhan and identify the optimal
diagnostic predictors for patients’ clinical prognoses. We applied an RF algorithm to predict the mortality of COVID-19 patients with high accuracy and identified LDH higher than 500 U/L and Myoglobin higher than 80 ng/ml to be potential risk factors for the
prognoses of COVID-19 patients in the early stage of the disease. |
|
Wang, L, Dong, et al |
Frontiers in Physics |
Epidemiology| Épidémiologie |
The aim of this study was to investigate the COVID-19 epidemic characteristics in Africa. In Africa, COVID-19 spreads
faster while with a relatively lower CFR, and it may be related to higher young people ratio. In addition, test intensity of COVID-19 is obviously insufficient in Africa. |
|
|
Wang, PG, Tang, et al |
Cell Discovery |
Therapeutics| Thérapeutique |
In the current study, we used SARS-CoV pseudotyped virus (HIV/SARS-CoV pseudovirus) to screen a siRNA library, and
identified AP2M1 as a crucial host factor for SARS-CoV infection. Based on the discovery, we further demonstrated that sunitinib, a kinase inhibitor involving in the regulation of AP2M1, not only inhibited the entry of HIV/SARS-CoV pseudovirus, but also functioned
on SARS-CoV-2 and MERS-CoV, thus held great potential as an anti-coronavirus drug. |
|
|
Wang, Xue, Sun, et al |
SSRN- Lancet prepublication |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Since the persistence of the novel coronavirus is sensitive to ambient temperatures, and that inactivation could be
achieved within minutes to half an hour at 50–60 °C, solar heating – by parking vehicles under direct sunlight with doors and windows closed – presents a viable strategy for passively disinfecting COVID-19 in vehicle interiors during warm-to-hot weather. To
demonstrate this approach, we measured the temperatures in a white compact-size sedan left in a parking lot under direct sunlight. The results supported our hypothesis that hot air generated by solar heating in enclosed objects provides a viable means of thermal
inactivation for COVID-19. |
|
|
Clinical characteristics and outcomes of COVID-19 infected patients
with type 2 diabetes mellitus |
Wang, Z, He, et al |
Chinese Journal of Endocrinology and Metabolism |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To observe the main clinical features and outcomes of type 2 diabetes mellitus patients after infection with COVID-19
and to compare them with those without diabetes mellitus. The clinical symptoms of type 2 diabetes patients with COVID-19 are diverse. They are often combined with diseases such as hypertension and chronic kidney disease. The inflammatory reaction is more
obvious and has more COVID-19 related complications and is more likely to progress into a persistent severe condition in a short time. |
|
Weiner, L, Berna, et al |
Trials |
RCT |
BACKGROUND: The acknowledgment of the mental health toll of the COVID-19 epidemic in healthcare workers has increased
considerably as the disease evolved into a pandemic status. Indeed, high prevalence rates of depression, sleep disorders, and post-traumatic stress disorder (PTSD) have been reported in Chinese healthcare workers during the epidemic peak. Symptoms of psychological
distress are expected to be long-lasting and have a systemic impact on healthcare systems, warranting the need for evidence-based psychological treatments aiming at relieving immediate stress and preventing the onset of psychological disorders in this population.
In the current COVID-19 context, internet-based interventions have the potential to circumvent the pitfalls of face-to-face formats and provide the flexibility required to facilitate accessibility to healthcare workers. Online cognitive behavioral therapy
(CBT) in particular has proved to be effective in treating and preventing a number of stress-related disorders in populations other than healthcare workers. The aim of our randomized controlled trial study protocol is to evaluate the efficacy of the 'My Health
too' CBT program-a program we have developed for healthcare workers facing the pandemic-on immediate perceived stress and on the emergence of psychiatric disorders at 3- and 6-month follow-up compared to an active control group (i.e., bibliotherapy). METHODS:
Powered for superiority testing, this six-site open trial involves the random assignment of 120 healthcare workers with stress levels > 16 on the Perceived Stress Scale (PSS-10) to either the 7-session online CBT program or bibliotherapy. The primary outcome
is the decrease of PSS-10 scores at 8 weeks. Secondary outcomes include depression, insomnia, and PTSD symptoms; self-reported resilience and rumination; and credibility and satisfaction. Assessments are scheduled at pretreatment, mid-treatment (at 4 weeks),
end of active treatment (at 8 weeks), and at 3-month and 6-month follow-up. DISCUSSION: This is the first study assessing the efficacy and the acceptability of a brief online CBT program specifically developed for healthcare workers. Given the potential short-
and long-term consequences of the COVID-19 pandemic on healthcare workers' mental health, but also on healthcare systems, our findings can significantly impact clinical practice and management of the ongoing, and probably long-lasting, health crisis. TRIAL
REGISTRATION: ClinicalTrials.gov NCT04362358 , registered on April 24, 2020. |
|
|
Welker, A, Kersten, et al |
ChemMedChem |
Therapeutics| Thérapeutique |
Herein we report on structure-activity relationships (SAR) of the noncovalent active-site directed inhibitor (R)-5-amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)
benzamide (2 b), which is known to bind into the S3 and S4 pockets of the SARS-CoV PLpro. Moreover, we report the discovery of isoindolines as a new class of potent PLpro inhibitors. The studies also provide a deeper understanding of the binding modes of this
inhibitor class. Importantly, the inhibitors were also confirmed to inhibit SARS-CoV-2 replication in cell culture. |
|
|
Werneck, AO, Silva, et al |
Public Health Nutr |
Public Health response| Interventions de santé publique |
Our aim was to analyze the association of change patterns on TV-viewing and computer/tablet use and incidence of elevated
consumption of ultra-processed food consumption and lower consumption of fruits and vegetables during the COVID-19 pandemic. Participants with incidence of sedentary behaviors were more likely to also present incidence of unhealthy diet during the COVID-19
pandemic quarantine. |
|
|
Werneck, AO, Silva, et al |
Sleep medicine |
Public Health response| Interventions de santé publique |
Our aim was to investigate the mediating role of worsening sleep quality in the association of the incidence of physical
inactivity (PI), high TV-viewing, and high computer/tablet use (PC) with loneliness, sadness, and anxiety during the COVID-19 pandemic quarantine. The incidence of PI, high TV, and high PC use were associated with loneliness, sadness, and anxiety feelings.
Worsening sleep quality partly mediated the association of the incidence of PI, high TV, and high PC use with loneliness, sadness, and anxiety. |
|
|
Westafer, LM, Soares, et al |
American Journal of Emergency Medicine |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
Noting high morbidity and mortality from early invasive mechanical ventilation, we implemented a COVID-19 respiratory
protocol employing high flow nasal cannula (HFNC) in severe COVID-19 and healthcare workers (HCW) exposed to COVID-19 patients on HFNC wore N95/KN95 masks. Utilization of HFNC increased significantly. We found no evidence of increased COVID-19 infections in
HCW after the implementation of the respiratory protocol. |
|
|
Wimba, PM, Bazeboso, et al |
Tropical Medicine and Health |
Public Health response| Interventions de santé publique |
Ten observers collected from street passers-by information on the adherence to barrier measures, the level of awareness
of these measures, the opinion on their usefulness, and the health status of people in the households. The use of barrier measures was very limited and that of masks practically nil despite repeated recommendations from the health authorities. The end of each
day was the worst moment due to clearly insufficient distancing. |
|
|
Woo, J, Leung, et al |
Journal of Nutrition, Health and Aging |
Public Health response| Interventions de santé publique |
The objective of this study was to document the trend in a quality of life indicator for the older Hong Kong population
as an assessment of the impact of age friendly city policies, political conflicts and the covid-19 pandemic. From 2017–9, improvements were seen in various domains in parallel with the adoption of the World Health Organization’s Age Friendly City concept by
government policy together with a territory wide initiative supported by a major philanthropic organization. However scores of all domains dropped markedly as a result of political conflicts and the COVID-19 pandemic. |
|
|
Performance of serum 2019-nCoV IgM/IgG detection in the rapid diagnosis
of COVID-19 |
Wu, N, Liu, et al |
Chinese Journal of Microbiology and Immunology (China) |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
The objective of this study was to evaluate the rapid diagnostic value of serum novel coronavirus (2019-nCoV) IgM/IgG
detection in COVID-19. Serum 2019-nCoV IgM/IgG detection (using colloidal gold method) had high sensitivity (84.4%) and strong specificity (94.1%) in the diagnosis of 2019-nCoV infection. Serum IgM showed a decreasing tread with prolonged disease course while
IgG showed an increasing trend with prolonged disease course and reached the peak in about 21-30 d. |
|
Wu, S, Xue, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To give insights on patient management within Fangcang hospitals, we conducted a retrospective analysis to: 1) describe
the characteristics of the patients admitted to Fangcang hospitals and 2) explore risk factors for longer length of stay (LOS). Longer duration of hospitalization among non-severe COVID-19 patients is associated with having fever, bilateral pneumonia on CT
scan and diabetes. However, being asymptomatic and using supportive medications at the early stage of infection do not have significant influences on LOS. |
|
|
Xi, Maomao, Cui, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A methodical comparison of confirmed and suspected COVID-19 patients has not been previously reported. Therefore, we
thoroughly analyzed the demographic and clinical characteristics between these groups to identify mortality risk factors. Confirmed patients exhibited more severe disease manifestations than those in suspected patients: a higher incidence of fever, lower lymphocyte
count, higher C-reactive protein (CRP), and more severe radiographic manifestations. Cox regression analysis demonstrated that lung disease, cardiovascular disease, neutrophil count, age, and ground-glass opacity lesions, were the main risk factors for mortality
in confirmed patients; lung disease, age, and CRP level were the primary factors in suspected patients. |
|
|
Xue, Z, You, et al |
Chinese Journal of Microbiology and Immunology (China) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to investigate the positive rates of 2019-nCoV nucleic acid in different specimens
from confirmed COVID-19 cases during hospitalization and after discharge. 2019-nCoV nucleic acid was detected in stool samples of confirmed COVID-19 cases during hospitalization. Nasal and throat swab nucleic acid tests turned positive again in some patients
after discharge. |
|
|
Yahyavi, A, Hemmati, et al |
Intern Emerg Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective cohort study, we aimed to compare the mortality rates in COVID-19 patients who received angiotensin-converting
enzyme inhibitors or angiotensin receptor blockers (ACEIs/ARBs) and those who did not. The mortality frequency was higher in patients with a history of underlying diseases. The use of ACEIs/ARBs was a protective factor against mortality in the model when adjusted
for underlying conditions, length of stay, age, gender, and ICU admission. The Kaplan-Meier curve showed an overall survival of approximately 85.7% after a 120-day follow-up. |
|
|
Prediction of COVID-19 prognosis by heterogeneity analysis based on chest
CT scans |
Yang, Bo, Zhang, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to estimate clinical outcome in individual COVID-19 patient by using histogram heterogeneity analysis
based on CT opacities. Two characteristic lung abnormity opacities, ground-glass opacity (GGO) and consolidation opacity (CLO) were drawn on CT images to identify the heterogeneity by using quantitative histogram analysis. The best performance heterogeneity
parameters to discriminate severe type from mild/moderate counterparts were as following: GGO_skewness and CLO_mean. |
|
32979425; Myocardial injury and risk factors for mortality in patients with COVID-19
pneumonia |
Yang, C, Liu, et al |
International journal of cardiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to explore the prevalence of myocardial injury and risk factors for mortality in patients with COVID-19
pneumonia. Two hundred and twenty-four consecutive patients with confirmed diagnosis of SARS-CoV-2 infection and definite outcomes (discharge or death) were retrospectively analyzed. Two hundred and three patients were included in the final analysis, consisting
of 145 patients who recovered and 58 patients who died. Compared with survivors, non-survivors were older, with more comorbidities, more severe inflammation and active coagulation function, higher levels of myocardial biomarkers and lower SaO2. 28 (50%) non-survivors
and 9 (6%) survivors developed myocardial injury, which was associated with disease severity at admission. Elevated d-dimer (OR = 9.51, 95% CI 3.61–25.0], P < 0.001), creatinine kinase-myocardial band (OR = 6.93, 95% CI 1.83–26.2], P = 0.004), Troponin I (OR
= 10.1, 95% CI 3.1–32.8], P < 0.001) and C-reactive protein (OR = 15.1, 95% CI 1.7–129.3], P = 0.013) were risk factors for mortality. Patients with abnormal levels of d-dimer, Troponin I and CRP were predicted to have significantly higher probability of death. |
|
Fast Climate Responses to Aerosol Emission Reductions During the COVID-19 Pandemic |
Yang, Y, Ren, et al |
Geophysical Research Letters |
Public health interventions*| Interventions de santé publique |
In January–March, there was an anomalous warming of 0.05–0.15 K in eastern China, and the surface temperature increase
was 0.04–0.07 K in Europe, eastern United States, and South Asia in March–May. The longer the emission reductions undergo, the warmer the climate would become. The emission reductions explain the observed temperature increases of 10–40% over eastern China
relative to 2019. A southward shift of the ITCZ is also seen in the simulations. This study provides an insight into the impact of COVID-19 pandemic on global and regional climate and implications for immediate actions to mitigate fast global warming |
|
Human Capital efficiency and equity funds’ performance during the COVID-19 pandemic |
Yarovaya, L, Mirza, et al |
International Review of Economics and Finance |
Economics | Économie |
The paper investigates the impact of human capital efficiency (HCE) on equity funds’ performance during three stages
of the COVID-19 pandemic. We collected data for 799 open-ended equity funds across five EU countries and ranked them in five categories of HCE and compare their risk-adjusted performance across these categories. The results suggest that during the COVID-19
outbreak, the equity funds that were ranked higher in HCE outperformed their counterparts. We suggest that fund managers should invest in human capital to improve funds’ coping ability and resilience during periods of extreme stress. © 2020 Elsevier Inc. |
|
Yellapu, NK, Patel, et al |
Vaccines |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Evolutionary analysis of 540 genomes spanning 20 different countries/territories was conducted and revealed an increase
in the genomic divergence across successive generations. The ancestor of the phylogeny was found to be the isolate from the 2019/2020 Wuhan outbreak. Its transmission was outlined across 20 countries/territories as per genomic similarity. Our results demonstrate
faster evolving variations in the genomic structure of SARS-CoV-2 when compared to the isolates from early stages of the pandemic. Genomic alterations were predominantly located and mapped onto the reported vaccine candidates of structural genes, which are
the main targets for vaccine candidates. S protein showed 34, N protein 25, E protein 2, and M protein 3 amino acid variations in 246 genomes among 540. Among identified mutations, 23 in S protein, 1 in E, 2 from M, and 7 from N protein were mapped with the
reported vaccine candidates explaining the possible implications on universal vaccines. Hence, potential target regions for vaccines would be ideally chosen from the structural regions of the genome that lack high variation. |
|
|
Yonker, LM, Neilan, et al |
Journal of Pediatrics |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Children ages 0-22 years with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection presenting
to urgent care clinics or being hospitalized for confirmed/suspected SARS-CoV-2 infection or multisystem inflammatory syndrome in children (MIS-C) at Massachusetts General Hospital were offered enrollment in the Massachusetts General Hospital Pediatric COVID-19
Biorepository. Enrolled children provided nasopharyngeal, oropharyngeal, and/or blood specimens. SARS-CoV-2 viral load, ACE2 RNA levels, and serology for SARS-CoV-2 were quantified. A total of 192 children (mean age, 10.2 ± 7.0 years) were enrolled. Forty-nine
children (26%) were diagnosed with acute SARS-CoV-2 infection; an additional 18 children (9%) met the criteria for MIS-C. Only 25 children (51%) with acute SARS-CoV-2 infection presented with fever; symptoms of SARS-CoV-2 infection, if present, were nonspecific.
Nasopharyngeal viral load was highest in children in the first 2 days of symptoms, significantly higher than hospitalized adults with severe disease (P = .002). Age did not impact viral load, but younger children had lower angiotensin-converting enzyme 2 expression
(P = .004). Immunoglobulin M (IgM) and Immunoglobulin G (IgG) to the receptor binding domain of the SARS-CoV-2 spike protein were increased in severe MIS-C (P < .001), with dysregulated humoral responses observed. This study reveals that children may be a
potential source of contagion in the SARS-CoV-2 pandemic despite having milder disease or a lack of symptoms; immune dysregulation is implicated in severe postinfectious MIS-C. |
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Zaworski, K, Kubińska, et al |
Disaster Med Public Health Prep |
Public Health response| Interventions de santé publique |
The aim of this paper is to present the engagement of adult Poles in physical activity (PA) before and during the coronavirus
pandemic, taking into consideration: frequency, duration and types of the activity depending on the gender and age of the participants. The study was conducted using an online survey questionnaire. 688 residents of Poland aged 18 to 58 (28.61±9.5) years old
participated in the study. A statistically significant decrease in the frequency of PA was noted in the group of men (p=0.0001) and in the age group of 39 to 58 years old. The analysis of the duration of a single PA before and during the pandemic has shown
a statistically significant reduction in the workout time among both men and women and across all age groups (p=0.05). There was a statistically significant increase in the frequency of women undertaking flexibility exercises, e.g. yoga (p=0.000), as well
as a decrease in marching and walks (p=0.003). Men significantly less frequently did strength exercises (p=0.002). |
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Zhang, J, Xie, et al |
International Journal of Contemporary Hospitality Management |
Public Health response| Interventions de santé publique |
The purpose of this paper is to examine the effect of hotel safety leadership on employee safety behavior during the
COVID-19 pandemic, and the mediation role of belief restoration and the moderation role of perceived risk between safety leadership and behavior were also investigated. The COVID-19 outbreak served as the background for a questionnaire survey of 23 hotels
in China with 1,594 valid responses being received. The statistical analysis techniques used were exploratory and confirmatory factor analysis, correlation analysis, structural equation modeling and hierarchical regression. The results showed that: hotel safety
leadership positively affected employee safety behavior (compliance, participation and adaptation); belief restoration partially mediated the influence of safety leadership on safety behavior; and perceived risk negatively moderated the direct effect and the
mediation effect of “safety leadership – belief restoration – safety behavior.” |
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Zhang, T |
Public health |
Public Health response| Interventions de santé publique |
Aim to study the relationship between regional case severities and the public interest using geographic information
system (GIS) techniques. To perform the analysis, the data were obtained from two sources. The COVID-19 case data were retrieved from the US health authority. Total confirmed cases per 100,000 population by state was retrieved, and divided the new confirmed
cases by the total previous cases and obtained a growth of new cases indicator. Public interest was captured by people's Google search data in each state. The correlation coefficient between growth of new cases and Google search interest (past 7 days) is highly
significant (r = 0.65, p < 0.001). The results also highlight the importance of the quality of internet search in coping with the pandemic which should be further strengthened. Hence, health authorities and internet service providers should strive to provide
the most up-to-date and reliable COVID-19 information to the public via the internet. |
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Zhang, Y |
|
Public Health response| Interventions de santé publique |
This study was focused on understanding the learning effect and influencing factors affecting students at home during
the epidemic, better help the college students in improving their learning efficiency, and achieving the state of "no suspension of classes". At first, we considered the students of science and engineering of Shandong University of management as an example
to collect the relevant data through the questionnaire; secondly, with the help of SPSS 23.0 software, factor analysis method is used to obtain three public factors affecting the learning outcomes of students: external interference factor, curriculum factor,
and emotional factor. At last, the actual situation of students and the results of the questionnaire have been combined in this paper, which puts forward practical improvement measures from the viewpoint of teachers and students. © Published under licence
by IOP Publishing Ltd. |
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Zhang, Y, Wu, et al |
Infection and Drug Resistance |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to build a model to predict the risk of developing severe pneumonia in patients with COVID-19 in the early
stage. Data from patients who were confirmed to have COVID-19 and were admitted within 7 days from the onset of respiratory symptoms were retrospectively collected. The patients were classified into severe and non-severe groups according to the presence or
absence of severe pneumonia during 1–2 weeks of follow-up. The neutrophil–lymphocyte ratio, monocyte counts, eosinophil percentage, serum lactate dehydrogenase level and history of diabetes mellitus were collected for the model. Bootstrap resampling showed
the apparent C-statistics, and the brier scores were 0.929 and 0.098. The optimism of the C-statistics and brier score was 0.0172 and −0.019, respectively. The adjusted C-statistics and brier score were 0.9108 and 0.1169, respectively. The optimal cut-off
value of the total nomogram score was determined to be 119 according to the maximal Youden index. The sensitivity, specificity, positive predictive value, and negative predictive value for differentiating the presence and absence of severe pneumonia were 83%,
89%, 74%, and 94%, respectively. In our study, the neutrophil–lymphocyte ratio, monocyte counts, eosinophil percentage, serum lactate dehydrogenase level and history of diabetes mellitus showed great discrimination and stability for the prediction of the presence
of severe pneumonia and were selected for the model. |
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Combating COVID-19 Together: China’s Collaborative Response and the Role of Business
Associations |
Zhang, Z, Shen, et al |
Nonprofit and Voluntary Sector Quarterly |
Public Health response| Interventions de santé publique |
Drawing on data from Zhejiang Province, this study explores China’s collaborative response to COVID-19 in which business
associations played a critical role. Consistent with existing literature on cross-sector collaboration and nonprofit contributions in extreme events, the preliminary findings of this study carry significant implications for future research to advance new knowledge.
Specifically, two important next steps of future research that hold considerable promise—examining the overwhelming impact of the institutional environment on collaboration and accounting for the complex mechanisms in which multiple components of collaboration
create outcomes through a configurational approach—emerged from this study. In addition, the practical implications of these findings are highlighted. © The Author(s) 2020. |
|
Zhao, S, Lin, et al |
Frontiers in Medicine |
Clinical data| Données cliniques |
The goal of this study was to investigate the clinical course and outcomes of patients with COVID-19 undergoing mechanical
ventilation and identify factors associated with death. Eighty-three consecutive critically ill patients with confirmed COVID-19 undergoing invasive mechanical ventilation were included in this retrospective, single-center, observational study from January
31 to March 15, 2020. Seventy-four out of 83 (89.2%) patients achieved oxygen saturation above 93% after intubation. Forty-nine out of 83 (59%) patients died and 34 (41%) patients survived after 28 days of observation. Multivariable regression showed increasing
odds of death associated with cardiac injury (odds ratio 15.60, 95% CI 4.20–74.43), liver injury (5.40, 1.46–23.56), and kidney injury (8.39, 1.63–61.41), and decreasing odds of death associated with the higher PaO2/FiO2 ratio before intubation (0.97, 0.95–0.99).
PaO2/FiO2 ratio before intubation demonstrated a positive linear correlation with platelet count (r = 0.424, P = 0.001), and negative linear correlation with troponin I (r = −0.395, P = 0.008). |
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32947051; Mental health crisis under COVID-19 pandemic in Hong Kong, China |
Zhao, SZ, Wong, et al |
International Journal of Infectious Diseases |
Public Health response| Interventions de santé publique |
To compare the mental health burden before and during the COVID-19 outbreak and identify the vulnerable groups by sociodemographic
factors. We analyzed repeated cross-sectional data from the Hong Kong Family and Health Information Trend Survey (FHInTS) in 2016 (N = 4036) and 2017 (N = 4051) and the COVID-19 Health Information Survey (CoVHInS) in April 9–23, 2020 (N = 1501) using population-based
random samples of general adults by landline telephone and online panel. Compared with 2016 and 2017, the stress level increased by 28.3%, prevalence of anxiety increased by 42.3%, and the depression symptoms and unhappiness have doubled (all P for trends
<0.001) during the COVID-19 outbreak. The increases in stress levels were significantly larger among older and less educated respondents (P for interactions <0.001). |
|
Re-positive nucleic acid detection in COVID-19 patients after discharge from
hospital |
Zhi, S, Xu, et al |
Chinese Journal of Laboratory Medicine |
Clinical data| Données cliniques |
Article in Chinese. Cases of 2019-nCoV nucleic acid and antibody (IgM and IgG total antibody) after discharge from
a hospital in Chongqing were continuously monitored. It was found that 5 cases of "re-positive" phenomenon, 5 cases of antibody were positive, and there was a trend of increasing with time. "Re-Positive" may be related to the following three factors. Children
with asymptomatic infection had a long time of fecal detoxification. There were two consecutive nucleic acid tests "false negative" caused by various reasons. The virus clearance in patients was not complete, and the discharge standard was not conservative
enough. The analysis of the causes of "Re-Positive" patients and the discussion of its infection will help us reveal more characteristics of this virus, and to provide a new basis for the discharge standard in the constantly updated diagnosis and treatment
programme. |
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33000108; Chest Radiography in Coronavirus Disease 2019 (COVID-19):
Correlation with Clinical Course |
Zhou, JC, Hui, et al |
Annals of the Academy of Medicine, Singapore |
Clinical data| Données cliniques |
In Singapore, rigorous contact tracing was practised to contain the spread of the virus. Nasal swabs and chest radiographs
(CXR) were also taken from individuals who were suspected to be infected by COVID-19 upon their arrival at a centralised screening centre. From our experience, about 40% of patients who tested positive for COVID-19 had initial CXR that appeared "normal". In
this case series, we described the temporal evolution of COVID-19 in patients with an initial "normal" CXR. Since CXR has limited sensitivity and specificity in COVID-19, it is not suitable as a first-line diagnostic tool. However, when CXR changes become
unequivocally abnormal, close monitoring is recommended to manage potentially severe COVID-19 pneumonia. |
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COVID-19 Australia: Epidemiology Report 27: Fortnightly reporting period ending 11
October 2020 |
|
Commun Dis Intell (2018) |
Epidemiology| Épidémiologie |
This Epidemiology Report 27 presents data on Australia COVID-19 for the period ending 11 October 2020 . The daily average
number of cases for this reporting period was 14 compared to an average of 23 cases per day in the previous fortnight. There were 192 cases of COVID-19 and 23 deaths this fortnight, bringing the cumulative case count to 27,344 and 898 deaths. While the majority
of cases in this reporting period were from Victoria (60%; 116/192), there continues to be a decrease in cases in this state resulting from public health interventions. During this fortnight, 66% (127/192) of all cases were reported as locally acquired, with
the majority reported from Victoria (108/127). The highest proportion of overseas-acquired cases was reported in New South Wales (75%; 38/51), followed by Western Australia (22%; 11/51). Although testing rates declined, they remain high overall at 9.2 tests
per week per 1,000 persons. |
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Domestic violence and substance abuse during COVID19: A systematic
review |
Abdo, C, Miranda, et al |
Indian Journal of Psychiatry |
Review Literature| Revue de littérature |
SR: from December 2019 through June 2020 an extensive bibliographic search was carried out in different medical databases:
Pubmed, EMBASE, LILACS, medRxiv, and bioRxiv. There is not enough evidence to support the concept that COVID-19 has led to an increase in the rates of domestic violence and substance abuse. The initial decrease in violence reports might not translate into
a real reduction in incidence but in accessibility. Apparently, there has been a slight increase in alcohol and tobacco abuse, especially by regular users, which also requires confirmatory studies. |
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Al Dawish, MA, Robert, et al |
Curr Diabetes Rev |
Review Literature| Revue de littérature |
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Al-Benna, S |
Annals of Burns and Fire Disasters |
Review Literature| Revue de littérature |
SR: systematic search of PubMed. Eight articles were included, and five articles emphasized that burn care professionals
should pay attention to prevent cross-infection. Only three articles reported in detail how burn care professionals should be protected during surgery in the operating room.
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Alimohamadi, Y, Sepandi, et al |
Journal of Preventive Medicine and Hygiene |
Review Literature| Revue de littérature |
SR-MA: review using Medline/PubMed, Scopus, and Google scholar has been conducted for articles published in the period
January 1, 2020, to April 2, 2020. Considering the main symptoms of COVID-19 such as Fever, Cough, Fatigue, and Dyspnea can have a key role in early detection of this disease and prevent the transmission of the disease to other people.
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Anantham, D, Chai-Lim, et al |
Journal of Intensive Care |
Review Literature| Revue de littérature |
ScR |
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Nanotechnology research and patents on coronavirus and COVID-19: a review |
Aranda, P, Wicklein, et al |
Recent Pat Nanotechnol |
Review Literature| Revue de littérature |
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Arashkia, A, Jalilvand, et al |
Reviews in medical virology |
Review Literature| Revue de littérature |
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Neurological manifestations of COVID-19: A literature review |
Arriola Torres, LF, Palomino Taype, et al |
Neurologia Argentina |
Review Literature| Revue de littérature |
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Arruda de Souza Monnerat, J, Ribeiro de Souza, et al |
Eur J Nutr |
Review Literature| Revue de littérature |
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COVID-19 and the world with co-morbidities of heart disease, hypertension and diabetes |
Arumugam, VA, Thangavelu, et al |
Journal of Pure and Applied Microbiology |
Review Literature| Revue de littérature |
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Ashikkali, L, Carroll, et al |
Paediatrics and Child Health (United Kingdom) |
Review Literature| Revue de littérature |
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Asif, M, Ajmal, et al |
Current Opinion in Electrochemistry |
Review Literature| Revue de littérature |
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The epigenetic implication in coronavirus infection and therapy |
Atlante, S, Mongelli, et al |
Clin Epigenetics |
Review Literature| Revue de littérature |
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Bakouny, Z, Hawley, et al |
Cancer Cell |
Review Literature| Revue de littérature |
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Banerjee, D, Vaishnav, et al |
Indian Journal of Psychiatry |
Review Literature| Revue de littérature |
SR:PubMed, Google Scholar, PSYCHINFO, EMBASE, and SCOPUS were searched till June 2020. The ongoing COVID-19 crisis
and its impact serve as an important period for adequate mental healthcare, promotion, research, and holistic biopsychosocial management of psychiatric disorders, especially in vulnerable groups. |
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The incubation period of COVID-19: A scoping review
and meta-analysis to aid modelling and planning |
Banka, Prakashini, Comiskey, et al |
medRxiv |
Review Literature| Revue de littérature |
ScR-MA: Five databases were searched; CINAHL, MEDLINE, PUBMED, EMBASE, ASSIA, and Global Index Medicus for studies
published between 1 January 2020 - 27 July 2020. Governments are planning their strategies on a maximum incubation period of 14 days. While our results are limited to primarily Chinese research studies, the findings highlight the variability in the mean period
and the potential for further incubation beyond 14 days. |
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Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus |
Beacon, T, Delcuve, et al |
Genome |
Review Literature| Revue de littérature |
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Child Development During the COVID-19 Pandemic Through a Life Course Theory Lens |
Benner, AD, Mistry, et al |
Child Development Perspectives |
Review Literature| Revue de littérature |
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Bhojraj, N, Shanbhog, et al |
World Journal of Dentistry |
Review Literature| Revue de littérature |
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Impact of COVID-19 and associated lockdown on livestock and poultry sectors
in India |
Biswal, J, Vijayalakshmy, et al |
Veterinary World |
Review Literature| Revue de littérature |
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Critical reappraisal of remdesivir investigational trials in COVID-19 |
Brouqui, P, Giraud-Gatineau, et al |
New Microbes and New Infections |
Review Literature| Revue de littérature |
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Buonsenso, D, Pata, et al |
Italian Journal of Gynaecology and Obstetrics |
Review Literature| Revue de littérature |
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Impact of COVID-19 on mental health: Update from the United Kingdom |
Burn, W, Mudholkar, et al |
Indian Journal of Psychiatry |
Review Literature| Revue de littérature |
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Cafiero, C, Re, et al |
Pharmacogenomics and Personalized Medicine |
Review Literature| Revue de littérature |
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Cannarella, R, Calogero, et al |
Therapeutic Advances in Endocrinology and Metabolism |
Review Literature| Revue de littérature |
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Channappanavar, R, Perlman, et al |
J Clin Invest |
Review Literature| Revue de littérature |
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Chen, Z, Hua, et al |
American Journal of Translational Research |
Review Literature| Revue de littérature |
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Cortes, AA, Zuñiga, et al |
Diagnostic microbiology and infectious disease |
Review Literature| Revue de littérature |
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Emerging mental health issues during the COVID-19 pandemic: An
Indian perspective |
Dalal, PK, Roy, et al |
Indian Journal of Psychiatry |
Review Literature| Revue de littérature |
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Dara, N, Hosseini, et al |
Iranian Journal of Pediatrics |
Review Literature| Revue de littérature |
SR-MA: We performed a systematic search of all the articles published up to May 2020 in the following databases: PubMed-MEDLINE,
Scopus, and Cochrane. According to our systematic review and meta-analysis, 26% of the children and adolescents diagnosed with COVID-19 present gastrointestinal symptoms. |
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Darwesh, AM, Bassiouni, et al |
Pharmacology and Therapeutics |
Review Literature| Revue de littérature |
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De Schutter, O, Lusiani, et al |
International Journal of Human Rights |
Review Literature| Revue de littérature |
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Demsie, DG, Gebre, et al |
Biologics: Targets and Therapy |
Review Literature| Revue de littérature |
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Duran, A, Núñez, et al |
Journal of Hispanic Higher Education |
Review Literature| Revue de littérature |
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20 Years of Nordic tourism economics research: a review and future research
agenda |
Falk, M, Tveteraas, et al |
Scandinavian Journal of Hospitality and Tourism |
Review Literature| Revue de littérature |
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Neurological manifestations of COVID-19: a systematic review and meta-analysis
of proportions |
Favas, TT, Dev, et al |
Neurol Sci |
Review Literature| Revue de littérature |
SR-MA: We searched the following electronic databases; PubMed, MEDLINE, Scopus, EMBASE, Google Scholar, EBSCO, Web
of Science, Cochrane Library, WHO database, and ClinicalTrials.gov . Neurological symptoms are common in SARS-CoV-2 infection, and from the large number of cases reported from all over the world daily, the prevalence of neurological features might increase
again. |
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Fernández-Capitán, C, Barba, et al |
Semin Thromb Hemost |
Review Literature| Revue de littérature |
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Fjældstad, AW, Ovesen, et al |
Ugeskrift for laeger |
Review Literature| Revue de littérature |
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Population-based prevalence surveys during the COVID-19
pandemic: a systematic review |
Franceschi, Vinicius Bonetti, Santos, et al |
medRxiv |
Review Literature| Revue de littérature |
SR: Systematic literature searches for published and unpublished (preprint) articles were 105 conducted from 15 July
to 05 September, 2020. MEDLINE (accessed via PubMed), Excerpta 106 Medica dataBASE (EMBASE), bioRxiv, and medRxiv databases. |
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Gao, Wenyan, Zhang, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
SR-MA: (before Apr 28, 2020) search using Pubmed, PMC, Web of Science, Embase, MedRixv, Google Scholar, Cochrane Library,
the Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biomedical Literature Database (CBM). Arbidol appeared to be the most efficacious drug for against COVID-19 infection. |
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Histopathologic Findings of Coronavirus in Lung: A Mini-Review |
Geramizadeh, B, Marzban, et al |
Clinical Pathology |
Review Literature| Revue de littérature |
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Coronavirus and Cardiovascular Disease, Myocardial Injury, and Arrhythmia: JACC
Focus Seminar |
Giustino, G, Pinney, et al |
Journal of the American College of Cardiology |
Review Literature| Revue de littérature |
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Ho, S, Tan, et al |
Annals of the Academy of Medicine, Singapore |
Review Literature| Revue de littérature |
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Stay-at-home orders and firearms in the United States during the COVID-19 pandemic |
Hoops, K, Johnson, et al |
Preventive medicine |
Review Literature| Revue de littérature |
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The Covid-19 pandemic and the struggle to tackle gender-based violence |
Ince Yenilmez, M |
Journal of Adult Protection |
Review Literature| Revue de littérature |
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COVID-19 and preventive measures for libraries in Pakistan: A commentary |
Jan, SU, Ali, et al |
Journal of Medical Sciences (Peshawar) |
Review Literature| Revue de littérature |
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Proposed Use of Continuous Glucose Monitoring for Care of Critically Ill COVID-19
Patients |
Jankovic, I, Basina, et al |
J Diabetes Sci Technol |
Review Literature| Revue de littérature |
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CRISPR-Based Diagnosis of Infectious and Noninfectious Diseases |
Jolany Vangah, S, Katalani, et al |
Biological Procedures Online |
Review Literature| Revue de littérature |
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Business-to-business marketing responses to COVID-19 crisis: a business process perspective |
Kang, J, Diao, et al |
Marketing Intelligence and Planning |
Review Literature| Revue de littérature |
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Combating SARS-CoV-2: leveraging microbicidal experiences with other emerging/re-emerging
viruses |
Khalid Ijaz, M, Sattar, et al |
PeerJ |
Review Literature| Revue de littérature |
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Khalifa, SAM, Yosri, et al |
Phytomedicine |
Review Literature| Revue de littérature |
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Kopel, J, Goyal, et al |
Baylor University Medical Center Proceedings |
Review Literature| Revue de littérature |
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Use of proton pump inhibitors and risk of adverse clinical outcomes from COVID-19: a meta-analysis |
Kow, CS, Hasan, et al |
J Intern Med |
Review Literature| Revue de littérature |
MA: searches in PubMed, Google Scholar and medRxiv (preprint repository) databases, up to 5 September 2020.
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SARS-CoV, MERS-CoV, and 2019-nCoV viruses: an overview of origin, evolution, and
genetic variations |
Krishnamoorthy, S, Swain, et al |
VirusDisease |
Review Literature| Revue de littérature |
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An insight
into the sars-cov-2: Use of zinc ionophores - a blockbuster approach |
Kumar, GJ |
Research Journal of Chemistry and Environment |
Review Literature| Revue de littérature |
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32867652; Feasibility of mesenchymal stem cell therapy for covid-19: A mini
review |
Li, J, Wang, et al |
Current Gene Therapy |
Review Literature| Revue de littérature |
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Lu, Q, Wang, et al |
Frontiers in Medicine |
Review Literature| Revue de littérature |
SR-MA: PubMed, China Wanfang Database, China Knowledge Resource Integrated Database (CNKI) were searched from inception
to July 15, 2020. In conclusion, current evidence suggests a significant negative association of peripheral lymphocyte levels with COVID-19 progression and mortality, but it was not significant in the subsets of CD3+ T cells, CD4+ T cells, CD8+ T cells, B
cells, and NK cells. |
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33007369; “Cytokine storm”, not only in COVID-19 patients. Mini-review |
Lukan, N |
Immunology letters |
Review Literature| Revue de littérature |
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Lupu, L, Palmer, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Magro, F, Rahier, et al |
J Crohns Colitis |
Review Literature| Revue de littérature |
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Marshall, DT, Bradley-Dorsey, et al |
Journal of School Choice |
Review Literature| Revue de littérature |
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Matsui, MS |
Current Dermatology Reports |
Review Literature| Revue de littérature |
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Min, YQ, Mo, et al |
Frontiers in Microbiology |
Review Literature| Revue de littérature |
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Cardiopulmonary resuscitation in prone position: A scoping review |
Moscarelli, A, Iozzo, et al |
American Journal of Emergency Medicine |
Review Literature| Revue de littérature |
ScR: searched PubMed, EMBASE, MEDLINE and pre-print repositories (bioRxiv and medRxiv) for simulation, pre-clinical
and clinical studies on reverse CPR until 31st May 2020. Even if the algorithms provided by the guidelines on basic and advanced life support remain valid in cardiac arrest in prone position, differences exist in the methods of performing CPR.
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Nolan, A, Bohoslavsky, et al |
International Journal of Human Rights |
Review Literature| Revue de littérature |
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Convalescent Plasma: The Relay Baton in the Race for Coronavirus Disease 2019 Treatment |
Ouyang, J, Isnard, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Ouyang, L, Gong, et al |
American Journal of Emergency Medicine |
Review Literature| Revue de littérature |
MA: search was conducted in PubMed, EMBASE, Scopus, Web of Science, MedRxiv Database. The results showed the levels
of sCr and BUN in non-survival cases remarkably elevated compared with survival patients, respectively (SMD = 0.97, SMD = 1.49). AKI is closely related with severity and mortality of COVID-19, which gives awareness for doctors to pay more attention for risk
screening, early identification and timely treatment of AKI. |
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33014121; Review on Diagnosis of COVID-19 from Chest CT Images Using Artificial Intelligence |
Ozsahin, I, Sekeroglu, et al |
Computational and mathematical methods in medicine |
Review Literature| Revue de littérature |
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Mobility impact and well-being in later life: A multidisciplinary systematic
review |
Pantelaki, E, Maggi, et al |
Research in Transportation Economics |
Review Literature| Revue de littérature |
SR: Scopus, Web of Science, PubMed, and TRID were seached.
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Paraiso, IL, Revel, et al |
Current Opinion in Food Science |
Review Literature| Revue de littérature |
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Pereda, N, Díaz-Faes, et al |
Child Adolesc Psychiatry Ment Health |
Review Literature| Revue de littérature |
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'Telepsychiatry' in the time of COVID-19: Overcoming the challenges |
Perera, SR, Gambheera, et al |
Indian Journal of Psychiatry |
Review Literature| Revue de littérature |
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Poonia, B, Kottilil, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Pragya, L, Alok, et al |
Research Journal of Biotechnology |
Review Literature| Revue de littérature |
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Qamar, SA, Basharat, et al |
Journal of Pure and Applied Microbiology |
Review Literature| Revue de littérature |
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Joining the dots? Tackling child exploitation during Covid-19 |
Racher, A, Brodie, et al |
Journal of Children's Services |
Review Literature| Revue de littérature |
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Propagation of n-cov cases in india from january to june 2020 |
Rajeswaran, SA, Smiline Girija, et al |
International Journal of Pharmaceutical Research |
Review Literature| Revue de littérature |
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The evolution of health care in the Texas correctional system and the impact
of COVID-19 |
Rao, S, Ali, et al |
Baylor University Medical Center Proceedings |
Review Literature| Revue de littérature |
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A review of the state of the climate crisis in the midst of the COVID-19 pandemic |
Rieder, HE |
Elektrotechnik und Informationstechnik |
Review Literature| Revue de littérature |
|
|
Rojas-Silva, O, Pavón-Rojas, et al |
Revista Cubana de Medicina Militar |
Review Literature| Revue de littérature |
|
|
|
Saleemi, MA, Ahmad, et al |
Infection, Genetics and Evolution |
Review Literature| Revue de littérature |
|
|
|
Impact of COVID-19 in Patients with Concurrent Co-Infections: A Systematic Review and Meta-Analyses |
Sarkar, Soumya, Khanna, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
SR-MA: The impact of COVID-19 in patients of concurrent infections with either Tuberculosis or Influenza is detrimental.
The clinical outcomes of COVID-19 in HIV or Chronic hepatitis patients are comparable to COVID-19 patients without these concurrent infections. |
|
Sarojini, K, Smiline Girija, et al |
International Journal of Pharmaceutical Research |
Review Literature| Revue de littérature |
|
|
|
Shah, S, Chawla, et al |
Saudi Journal of Anaesthesia |
Review Literature| Revue de littérature |
|
|
|
Sharma, H, Verma, et al |
Saudi Journal of Anaesthesia |
Review Literature| Revue de littérature |
|
|
|
Sharma, I, Vashnav, et al |
Indian Journal of Psychiatry |
Review Literature| Revue de littérature |
|
|
|
Double burden of excess weight and anemia in Latin American children up to 2019 |
Shimabuku, RL, Delgado, et al |
Tohoku Journal of Experimental Medicine |
Review Literature| Revue de littérature |
|
|
Siegel, CA, Christensen, et al |
J Crohns Colitis |
Review Literature| Revue de littérature |
|
|
|
Smondack, P, Gravier, et al |
Revue des maladies respiratoires |
Review Literature| Revue de littérature |
|
|
|
Application of microbial informatics in the prediction of novel vaccines for n-CoV |
Sogasu, D, Smiline Girija, et al |
International Journal of Pharmaceutical Research |
Review Literature| Revue de littérature |
|
|
Song, JW, Long, et al |
Chinese Medicine (United Kingdom) |
Review Literature| Revue de littérature |
|
|
|
Bereavement in Times of COVID-19: A Review and Theoretical Framework |
Stroebe, M, Schut, et al |
Omega (Westport) |
Review Literature| Revue de littérature |
|
|
Role of clinical pharmacists in telemonitoring for patients with Coronavirus Disease 2019
(COVID-19) |
Surapat, B, Sungkanuparph, et al |
J Clin Pharm Ther |
Review Literature| Revue de littérature |
|
|
Management of mass death in COVID-19 pandemic in Indian perspective |
Swain, R, Sahoo, et al |
Disaster Med Public Health Prep |
Review Literature| Revue de littérature |
|
|
Tang, Z, Kong, et al |
Nature Reviews Materials |
Review Literature| Revue de littérature |
|
|
|
Double Trouble: Combined Cardiovascular Effects of Particulate Matter Exposure and COVID-19 |
Tanwar, V, Adelstein, et al |
Cardiovasc Res |
Review Literature| Revue de littérature |
|
|
Thomas, N, Dionysiou, et al |
Journal of hazardous materials |
Review Literature| Revue de littérature |
|
|
|
Vlachakis, D, Papakonstantinou, et al |
Food and Chemical Toxicology |
Review Literature| Revue de littérature |
|
|
|
Wei, JS |
Australian journal of general practice |
Review Literature| Revue de littérature |
|
|
|
Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review |
Yang, CJ, Wei, et al |
Journal of Microbiology, Immunology and Infection |
Review Literature| Revue de littérature |
|
|
Yang, H, Lan, et al |
Virol J |
Review Literature| Revue de littérature |
MA: PubMed, Embase and Web of Science databases were searched. . Based on chest CT features of COVID-19 mentioned,
it might be a promising means for identifying COVID-19. |
|
|
Zhang, XR, Li, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
|
|
|
Zhang, YM, Wang, et al |
J Proteome Res |
Review Literature| Revue de littérature |
|
|
|
Zhu, HD, Xiong, et al |
Journal of Cancer Research and Therapeutics |
Review Literature| Revue de littérature |
|
|
|
Zisook, RE, Monnot, et al |
Toxicol Ind Health |
Review Literature| Revue de littérature |
|
|
|
Aali, R, Rabori, et al |
Environmental Health Engineering and Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Abraham, BP, Nag, et al |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Adelson, M |
Journal of Structured Finance |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ahmad, MF, Mahakkanukrauh, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Al-Busaidi, I, Martin, et al |
The New Zealand medical journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32997483; Use of chloroquine or hydroxychloroquine in treatment of COVID-19: is it ethical? |
Allam, MF, Andraous, et al |
Central European journal of public health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Alpar, P, Osterbrink, et al |
Information Systems Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sterility Special Interest Group position paper on ART treatments and COVID-19 pandemic |
Alviggi, C, Borini, et al |
Italian Journal of Gynaecology and Obstetrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Amat-Santos, I, Santos-Martinez, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Anand, S, Mamidi, et al |
Leprosy review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
An assessment of socioeconomic impact of COVID-19 pandemic in India |
Aneja, R, Ahuja, et al |
Journal of Public Affairs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ángeles Ordóñez Alonso, MA, Aurrecoechea, et al |
Pediatria de Atencion Primaria |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Arachchillage, DJ, Desai, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Arastehfar, A, Carvalho, et al |
Journal of Fungi |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ardila, EKG, Santaella-Tenorio, et al |
Colombia Medica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Aschwanden, C |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Aven, T, Zio, et al |
Reliab Eng Syst Saf |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Science is just another opinion: Making medical stories count post–COVID-19 |
Baer, N |
Perspectives in biology and medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bajaj, S, Blair, et al |
Nature and Science of Sleep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bakker, A, Riper, et al |
European Journal of Psychotraumatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Balta, Ş |
Angiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Barnard, H |
Management and Organization Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Barreiro, D, Montiel, et al |
Medicina (Argentina) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bateman, T |
Journal of Children's Services |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Multisystem Inflammatory Syndrome in Children in the United States |
Belot, A, Levy-Bruhl, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Benavides-Cordoba, V |
Colombia Medica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bentivegna, E, Alessio, et al |
American Journal of Infection Control |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Berling, I, Hoffman, et al |
JAMA Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 and obesity: An association with multiple consequences |
Bertin, E |
Cahiers de Nutrition et de Dietetique |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bianco, M, Biolè, et al |
JAMA Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
How the COVID-19 pandemic could reduce near-retirees' Social Security benefits |
Biggs, AG |
Journal of Pension Economics and Finance |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bikdeli, B |
Thrombosis research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Binnicker, MJ |
J Clin Microbiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bisseling, TM, van Laarhoven, et al |
Am J Gastroenterol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Neo-liberal reforms
in higher education accelerated by the pandemic |
Biswas, D |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The responsible use and dissemination of information in a pandemic: An ethical
imperative |
Blanca, BP, Luengo-Charath, et al |
Revista chilena de pediatria |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Contributive action: socially mediated activities of Russians during the COVID-19
lockdown |
Bodrunova, SS |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Boettner, F, Bostrom, et al |
HSS Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33000616; Can estrogens protect against COVID-19? The COVID-19 puzzling and
gender medicine |
Bonaccorsi, G, Gambacciani, et al |
Minerva ginecologica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Role of lung ultrasound in patients requiring emergency surgery during COVID-19 Pandemic |
Brachini, G, Sapienza, et al |
British Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bradshaw, PC, Seeds, et al |
Oxidative Medicine and Cellular Longevity |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Consequences for the Elderly After COVID-19 Isolation: FEaR (Frail Elderly amid
Restrictions) |
Briguglio, M, Giorgino, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Stretch-Thinking Loops: A New Technique for Scenario Planning |
Brooks, B, Curnin, et al |
Risk, Hazards and Crisis in Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Burkle, FM, Bradt, et al |
Prehosp Disaster Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Burkle, FM, Bradt, et al |
Prehosp Disaster Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Using Simulation to Develop Solutions for Ventilator Shortages From the Epicenter |
Burnett, GW, Shah, et al |
Simul Healthc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Busilacchi, G |
Politiche Sociali |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cabero-Almenara, J |
Revista Electronica Educare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm
Syndromes |
Cabler, SS, French, et al |
Trends in molecular medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Clinical Symptoms of Hyperandrogenic Women Diagnosed with COVID-19 |
Cadegiani, FA, Lim, et al |
J Eur Acad Dermatol Venereol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Environmentally sustainable health care: now is the time for action |
Capon, A, Madden, et al |
Med J Aust |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Harnessing Collaborative Care to Meet Mental Health Demands in the Era of
COVID-19 |
Carlo, AD, Barnett, et al |
JAMA Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Therapeutic options to cytokine release syndrome in patients
with covid-19 |
Cartas, US, Larrarte, et al |
Revista Cubana de Medicina Militar |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Carvalho, BR, Fonseca, et al |
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Commercial airline routes and international distribution of COVID-19 |
Casal, ER, Catalano, et al |
Medicina (Argentina) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cavaliere, AF, Vasarri, et al |
Italian Journal of Gynaecology and Obstetrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pulmonary Angiopathy in Severe COVID-19: Physiological Conclusions Derived from
Ventilatory Ratio? |
Caviedes, I, Soto, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cerdas-Montano, V, Mora-Espinoza, et al |
Revista Electronica Educare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Desperate times call for evidence-based measures: Prioritizing science during the
COVID-19 pandemic |
Chagla, Z, Laupland, et al |
JAMMI |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Understanding Gender-Bias in Critically Ill Patients With COVID-19 |
Chamekh, M, Casimir, et al |
Frontiers in Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Chanarat, S, Charoensawan, et al |
ScienceAsia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Disability during COVID-19: Increasing vulnerability
and neglect |
Chanda, S, Sekher, et al |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Charters, C |
MAI Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The psycho
social ramifications of the COVID 19 — A personal treatise |
Chatterjee, N |
Journal of the Indian Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Professional Life during COVID-19 Crisis: An Emotional and Ethical Dilemma for the Medical
Staff |
Chehrehgosha, M, Royani, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Chen, ALQ |
Acta Sociologica (United Kingdom) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chen, L, Tang, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Construction and implementation of blended online teaching mode based on live
broadcasting and MOOC |
Chen, Y, Zheng, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Recency of practice and emergency registration: Preparing for surge capacity in the
time of COVID-19 |
Chiarella, M, Stewart, et al |
Australian Journal of Advanced Nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Towards a "Net" generation of Pathologists: the pathCast online remote learning platform |
Cima, L, Mannan, et al |
Pathologica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 vaccines: the importance of transparency and fact-based education |
Cohen, AF, van Gerven, et al |
British journal of clinical pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Immune computation and covid-19 mortality: A rationale for ivig |
Cohen, IR, Efroni, et al |
Critical reviews in immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Conejo, LD, Chaverri-Chaves, et al |
Revista Electronica Educare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Couch, DL, O'Sullivan, et al |
Gender, Work and Organization |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Could ozone be an effective disinfection measure against the novel coronavirus
(SARS-CoV-2)? |
Cristiano, L |
Journal of Preventive Medicine and Hygiene |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Crockford, D |
Canadian Journal of Addiction |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Why physical activity matters for older adults in a time of pandemic |
Cunningham, C, O' Sullivan, et al |
European Review of Aging and Physical Activity |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Danchin, M, Manski-Nankervis, et al |
Australian journal of general practice |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Das, A, Sutradhar, et al |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pandemic in a smart city: Singapore’s COVID-19 management through technology
& society |
Das, D, Zhang, et al |
Urban Geography |
Commentary/Editorial| Commentaire/Éditorial |
|
|
David, Hmsl, Acioli, et al |
Rev Gaucha Enferm |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Spatiotemporal Integration of Tuberculosis and COVID-19 during the COVID-19
Pandemic in Libya |
Daw, MohamedA, Zgheel, et al |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
|
|
de Agustín Asensio, JC |
Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The mythologisation of key workers: occupational prestige gained, sustained.. and
lost? |
De Camargo, CR, Whiley, et al |
International Journal of Sociology and Social Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 pandemic and infarctions: another call to reorganise our healthcare
systems |
De Filippo, O, D'Ascenzo, et al |
Heart |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The pedagogy of death in the context of the pandemic: A radical
and inclusive view |
de la Herrán Gascón, A |
Revista Electronica Educare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Management of Pregnant Inflammatory Bowel Disease Patients During the COVID-19 Pandemic |
De Lima-Karagiannis, A, Juillerat, et al |
J Crohns Colitis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The 15 minutes-city, a sustainable solution for postCOVID19 cities? |
de Valderrama, NMF, Luque-Valdivia, et al |
Ciudad y Territorio Estudios Territoriales |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The South African archaeological society (SAAS) and
COVID-19 |
Deacon, J |
South African Archaeological Bulletin |
Commentary/Editorial| Commentaire/Éditorial |
|
|
DeFrancesco, L |
Nat Biotechnol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Activating Embodied Imagination During COVID-19: A Performative Reflexive Autoethnography |
DeGarmo, MB |
Qualitative Inquiry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Postmarketing studies: can they provide a safety net for COVID-19 vaccines in the
UK? |
Dhanda, S, Osborne, et al |
BMJ Evid Based Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Donati, A |
European Journal of Risk Regulation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
An original logigramme to make safe discharge and community reintegration
for COVID-19 patients |
Donno, F, Fedele, et al |
Journal of Preventive Medicine and Hygiene |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Doshi, P |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Will covid-19 vaccines save lives? Current trials aren't designed to tell us |
Doshi, P |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Immunological considerations for SARS-CoV-2 human challenge studies |
Douglas, AD, Hill, et al |
Nat Rev Immunol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Optimism bias during the covid-19 pandemic: Empirical evidence from romania and italy |
Druică, E, Musso, et al |
Games |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nursing and mental health: a reflection in the midst of the coronavirus pandemic |
Duarte, MLC, Silva, et al |
Rev Gaucha Enferm |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Aftermath of COVID-19: Need for developing novel bedside communication skills? |
Dubey, N, Dubey, et al |
Saudi Journal of Anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Decrease in Stroke Diagnoses During the COVID-19 Pandemic: Where Did All Our Stroke Patients
Go? |
Dula, AN, Gealogo Brown, et al |
JMIR Aging |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Duman, B, Herdi, et al |
Noropsikiyatri Arsivi |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Durygin, M |
Prospects |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Article
15 derogations: Are they really necessary during the COVID-19 pandemic? |
Dzehtsiarou, K |
European Human Rights Law Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Edahiro, A, Okamura, et al |
Psychogeriatrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Egyir, B, Obeng-Nkrumah, et al |
African Journal of Laboratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Eichenbaum, M |
Israel Economic Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
El-Guebaly, N |
Canadian Journal of Addiction |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Etienne, CF, Fitzgerald, et al |
BMJ Global Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Everly, GS, Wu, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Products in a Pandemic: Liability for Medical Products and the Fight against COVID-19 |
Fairgrieve, D, Feldschreiber, et al |
European Journal of Risk Regulation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Félix Cayo Rojas, C, Miranda Dávila, et al |
Revista Cubana de Educacion Medica Superior |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Everyday citizenship and COVID-19: “Staying at home” while homeless |
Fenley, VM |
Administrative Theory and Praxis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Fenton, E |
The New Zealand medical journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Fernández Cervantes, R, Souto Camba, et al |
Fisioterapia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
[Recommendations on neurophysiological studies during the COVID-19 pandemic] |
Fernández-Sánchez, VE, Martínez-Martínez, et al |
Rev Neurol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Flaskerud, JH |
Issues Ment Health Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Flor, N, Dore, et al |
AJR Am J Roentgenol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Földi, M, Farkas, et al |
Obesity Reviews |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The UNA quality education project in the context of COVID-19 |
Fontana-Hernández, A, Herrera-Sibaja, et al |
Revista Electronica Educare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ivermectin: an award-winning drug with expected antiviral activity against COVID-19 |
Formiga, FR, Leblanc, et al |
Journal of Controlled Release |
Commentary/Editorial| Commentaire/Éditorial |
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Forsythe, P |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Cardiac Dysfunction in Multisystem Inflammatory Syndrome in Children: A Call to
Action |
Friedman, KG, Harrild, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Furman, L, Noble, et al |
Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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The challenge of being a university professor
in times of COVID-19 in contexts of inequality |
Gajardo-Asbún, K, Paz-Maldonado, et al |
Revista Electronica Educare |
Commentary/Editorial| Commentaire/Éditorial |
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Galanopoulou, AS, McArthur, et al |
Epilepsia Open |
Commentary/Editorial| Commentaire/Éditorial |
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Exploring the Role of Endothelial Cell Resilience in Cardiovascular Health and
Disease |
Gao, Y, Galis, et al |
Arterioscler Thromb Vasc Biol |
Commentary/Editorial| Commentaire/Éditorial |
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Some fun pedagogical techniques to teach optics to students of all ages |
Garg, A, Sharma, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
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Public health lessons: Odisha's management of the
covid-19 pandemic |
Garikipati, N |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and Chinese Global Health Diplomacy: Geopolitical Opportunity for China’s
Hegemony? |
Gauttam, P, Singh, et al |
Millennial Asia |
Commentary/Editorial| Commentaire/Éditorial |
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Geetika, G, Ashok, et al |
Research Journal of Chemistry and Environment |
Commentary/Editorial| Commentaire/Éditorial |
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What our response to the COVID-19 pandemic tells us of our capacity to respond to
climate change |
Gemenne, F, Depoux, et al |
Environmental Research Letters |
Commentary/Editorial| Commentaire/Éditorial |
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Giesen, N, Sprute, et al |
European journal of cancer |
Commentary/Editorial| Commentaire/Éditorial |
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Giraldo, EB |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Glazer, J |
Israel Economic Review |
Commentary/Editorial| Commentaire/Éditorial |
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Gloviczki, PJ |
Journal of Loss and Trauma |
Commentary/Editorial| Commentaire/Éditorial |
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Human rights and democracy in economic policy reform: the European COVID-19
response under scrutiny |
Goldmann, M |
International Journal of Human Rights |
Commentary/Editorial| Commentaire/Éditorial |
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Statins in liver cirrhosis in a developing country: benefits overweigh the risk? |
Gonzáles Yovera, JG, Concepción-Zavaleta, et al |
Expert Opin Drug Saf |
Commentary/Editorial| Commentaire/Éditorial |
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A challenge for cuban medical education in times of pandemic |
González-García, S, Casadelvalle Pérez, et al |
Revista Cubana de Educacion Medica Superior |
Commentary/Editorial| Commentaire/Éditorial |
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A preliminary report on plant based immunity against sars-cov-2
(covid-19) in pandemic 2020 |
Gopal, SG |
Research Journal of Biotechnology |
Commentary/Editorial| Commentaire/Éditorial |
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|
Gorman, D, Horn, et al |
The New Zealand medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Second wave death rate is doubling fortnightly but is lower and slower than in
March |
Griffin, S |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in pastoral contexts in the greater Horn of Africa: Implications and recommendations |
Griffith, EF, Pius, et al |
Pastoralism |
Commentary/Editorial| Commentaire/Éditorial |
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The clinical application of serum amyloid A in the diagnosis and treatment
of COVID-19 |
Gu, M, Gu, et al |
Chinese Journal of Laboratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Gupte, J, Mitlin, et al |
Environment and Urbanization |
Commentary/Editorial| Commentaire/Éditorial |
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Hadid, T, Kafri, et al |
Blood reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Children’s and families’ behavioral and mental health during COVID-19 |
Hageman, JR |
Pediatric annals |
Commentary/Editorial| Commentaire/Éditorial |
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|
Hainer, V, Kunešová, et al |
Prakticky Lekar |
Commentary/Editorial| Commentaire/Éditorial |
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Hamilton, DO, Waite, et al |
Arterioscler Thromb Vasc Biol |
Commentary/Editorial| Commentaire/Éditorial |
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Han, J, He, et al |
Environmental Pollution |
Commentary/Editorial| Commentaire/Éditorial |
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Hashmi, F, Atif, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
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|
Hazarika, A, Agrawal, et al |
Postgrad Med J |
Commentary/Editorial| Commentaire/Éditorial |
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Update Alert 3: Hydroxychloroquine or Chloroquine for the Treatment or Prophylaxis of COVID-19 |
Hernandez, AV, Roman, et al |
Ann Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
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Herrera-Villalobos, G, Salazar-Arias, et al |
Revista Electronica Educare |
Commentary/Editorial| Commentaire/Éditorial |
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|
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Personal protective equipment from the hybrid urban microfactory |
Hildebrandt, L, Redlich, et al |
ZWF Zeitschrift fuer Wirtschaftlichen Fabrikbetrieb |
Commentary/Editorial| Commentaire/Éditorial |
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Hogue, A, Becker, et al |
Journal of substance abuse treatment |
Commentary/Editorial| Commentaire/Éditorial |
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Tropical cyclone harold meets the novel coronavirus: Dispatch from the pacific |
Holland, E |
Pacific Journalism Review |
Commentary/Editorial| Commentaire/Éditorial |
|
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32961275; Anti-science extremism in America: escalating and globalizing |
Hotez, PJ |
Microbes and Infection |
Commentary/Editorial| Commentaire/Éditorial |
|
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Antipsychotic prescribing to people with dementia during COVID-19 |
Howard, Robert, Burns, et al |
The Lancet Neurology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hsien-Xiong Lee, R, Peiying Ho, et al |
The Journal of frailty & aging |
Commentary/Editorial| Commentaire/Éditorial |
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|
|
In Search of Wise Management of Medical Resources and Personnel in the Long Combat
With Coronavirus |
Hu, YR, Wang, et al |
Frontiers in Sociology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hughto, JMW, Peterson, et al |
Journal of substance abuse treatment |
Commentary/Editorial| Commentaire/Éditorial |
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|
|
Ibáñez, B |
Revista espanola de cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Iglesias-Osores, S |
Revista Cubana de Medicina Militar |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32994600; Reflections on conducting research with healthcare users in a pandemic
lockdown |
Imlach, F |
The New Zealand medical journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Indu, Subramanian, Christina, et al |
Parkinsonism and Related Disorders |
Commentary/Editorial| Commentaire/Éditorial |
|
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33001436; Changes in the status of COVID-19 over time necessitate major changes in academics |
Inoue, K, Hashioka, et al |
International maritime health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Prevention of occupational stress in health-care workers during
COVID-19 pandemic |
Irfan, M, Naeem, et al |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Exist or exit? Women business-owners in Bangladesh during COVID-19 |
Jaim, J |
Gender, Work and Organization |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7533762; Commentary on 'inimical effects of COVID-19 on surgical residency:
Correspondence' |
Jaumdally, H, Salih, et al |
Ann Med Surg (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Jazieh, AR, Chan, et al |
JCO global oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pulmonary Vascular Changes in Acute Respiratory Distress Syndrome Due to COVID-19 |
Jha, AK |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A novel transparent box for intubation in a suspect/confirmed coronavirus disease (COVID-19)
patient |
Jilani, T, Simbawa, et al |
Saudi Journal of Anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Critical integration of emerging technologies in teacher education:
Looking to the future |
Jiménez-Sánchez, S |
Revista Electronica Educare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Johnson, AF, Roberto, et al |
Public Administration and Development |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kant, S |
Journal of the Indian Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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|
|
Kappel, ES |
Oceanography |
Commentary/Editorial| Commentaire/Éditorial |
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|
|
Kawharu, M |
MAI Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kendrick, K, Isaac, et al |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Covid-19 and the increasing centrality and power of platforms in China, the US, and beyond |
Kenney, M, Zysman, et al |
Management and Organization Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
SAMHD1 as the Potential Link Between SARS-CoV-2 Infection and Neurological Complications |
Khan, A, Sergi, et al |
Frontiers in Neurology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Khan, L |
Pediatric annals |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Transnational contracts and their performance during the COVID-19 crisis:
Reflections from India |
Khanderia, S |
BRICS Law Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19: A Cloud with a Silver Lining for Renewable Energy? |
Khanna, M |
Applied Economic Perspectives and Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Khargekar, N, Khanna, et al |
Asia-Pacific Journal of Oncology Nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The challenges ahead for patients with feeding and eating disorders during the
COVID-19 pandemic |
Khosravi, M |
Journal of Eating Disorders |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Khoury, M, Rocco, et al |
Cytotherapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kidane, B, Levin, et al |
Journal of Thoracic Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kim, JE, Lee, et al |
J Public Health Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
All’s not well with the “worried well”: Understanding health anxiety
due to COVID-19 |
Kini, G, Karkal, et al |
Journal of Preventive Medicine and Hygiene |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kleinman, A |
Perspectives in biology and medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cyanoamidine Cyclization Approach to Remdesivir's Nucleobase |
Knapp, RR, Tona, et al |
Org Lett |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Koopmann, A, Georgiadou, et al |
Alcohol Alcohol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Koreki, A, Nakane, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 and the Acceleration of Digital Transformation and the Future of Work |
Kudyba, S |
Information Systems Management |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kukutai, T, McIntosh, et al |
MAI Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lancaster, EM, Wu, et al |
Journal of Vascular Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A supportive electrostatic model of the COVID-19 airborne transmission |
Lattarulo, F |
International Journal of Modeling, Simulation, and Scientific Computing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Does the end justify the means?Information systems and control society in the
age of pandemics |
Leclercq-Vandelannoitte, A, Aroles, et al |
European Journal of Information Systems |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The COVID-19 pandemic: Global health policy and technology responses in the making |
Lee, D, Moy, et al |
Health Policy and Technology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Scalable HPC and AI Infrastructure for COVID-19 Therapeutics |
Lee, Hyungro, Merzky, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lee, RM, Tan, et al |
Annals of the Academy of Medicine, Singapore |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lefeuvre, C, Przyrowski, et al |
Actualites Pharmaceutiques |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Leonardi, PM |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lewin, S, Lees, et al |
J Crohns Colitis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lewis, O |
European Human Rights Law Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Li, F, Lu, et al |
Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Provisional case definitions for COVID-19-associated neurological disease |
Li, Hai-Feng, Hao, et al |
The Lancet Neurology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Research of Big Data Analysis Platform Based on Positioning Information |
Li, X, Wang, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Linh, TNQ, Hanh, et al |
International Journal of Disaster Resilience in the Built Environment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lipsitch, M, Dean, et al |
Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32971021; Scientific Losses and Gains During the COVID-19 Shutdown |
Liu, KC |
American Journal of Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Opinion: A risk-benefit framework for human research during the COVID-19 pandemic |
Lumeng, JC, Chavous, et al |
Proc Natl Acad Sci U S A |
Commentary/Editorial| Commentaire/Éditorial |
|
|
33015681; Management of conjunctivitis and other causes of red eye during the COVID-19
pandemic |
Mack, HG, Khan, et al |
Australian journal of general practice |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Somewhere over the rainbow - Third sector research in and beyond coronavirus |
Macmillan, R |
Voluntary Sector Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Maglia, E |
Politiche Sociali |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19: Harshest restrictions are imposed on Greater Manchester after talks collapse |
Mahase, E |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Makoni, M |
Physics World |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Finding Opportunities for Healthcare System Advancement in the COVID-19 Crisis |
Malish, RG, Meyers, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Marin-Cots, P, Palomares-Pastor, et al |
Ciudad y Territorio Estudios Territoriales |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Marinelli, E, Negro, et al |
Italian Journal of Gynaecology and Obstetrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Emergency healthcare facilities: managing design in a post COVID-19 world |
Marinelli, M |
IEEE Engineering Management Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Patients with juvenile idiopathic arthritis on TNF inhibitors exposed to
COVID-19 family members |
Marino, A, Romano, et al |
Seminars in arthritis and rheumatism |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mark, AM |
Journal of the American Dental Association |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
May, JR, Daly, et al |
Law, Culture and the Humanities |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Environmentally sustainable health care: now is the time for action |
McGain, F, Chamberlin, et al |
Med J Aust |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Leadership and Governance in Times of Crisis: A Balancing Act for Nonprofit Boards |
McMullin, C, Raggo, et al |
Nonprofit and Voluntary Sector Quarterly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Coronavirus and Cardiometabolic Syndrome: JACC Focus Seminar |
Mechanick, JI, Rosenson, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Public health crises and the need for accessible information |
Meltzer, A |
Med J Aust |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The pitfalls of mass hospital health care worker testing for covid-19 |
Mertz, D, Evans, et al |
JAMMI |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Miguel, LS, Goldschmidt, et al |
Medicina (Argentina) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Miller, J |
Smith College Studies in Social Work |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Miller, KE |
Gender, Work and Organization |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Minari, J, Yoshizawa, et al |
EMBO Rep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Reconfiguring
fill/finish inspection to meet COVID-19 vaccine goals |
Mirasol, F |
BioPharm International |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Misak, C |
Perspectives in biology and medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mishra Arunesh, K, Pratibha, et al |
Research Journal of Chemistry and Environment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33001435; Cloud-based framework to mitigate the impact of COVID-19 on seafarers' mental
health |
Mittal, M, Battineni, et al |
International maritime health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mohapatra, PR, Mishra, et al |
Postgrad Med J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Differences in COVID-19 risk between occupational groups and employment sectors
in Germany |
Möhner, M, Wolik, et al |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Moller, DPF, Jehle, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
CIDE's educational management route in the context of COVID-19 |
Montes-Rodríguez, AL, Chen-Quesada, et al |
Revista Electronica Educare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The International Day of Light in Spain: A three years perspective |
Moreno, I, Yzuel, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Morrill, Z |
Journal of Humanistic Psychology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mukherji, R |
Journal of Democracy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mukwenha, S, Dzinamarira, et al |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Müller, R, Klein, et al |
Project Management Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33012894; Covid-19 in latin america: A first glance to the mortality |
Muñoz, N |
Colombia Medica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Naeem, F, Omair Husain, et al |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nair, A, Diwan, et al |
Saudi Journal of Anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Neagu, M |
J Immunoassay Immunochem |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ng, SC, Mak, et al |
J Crohns Colitis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ngam, PI, Goh, et al |
Annals of the Academy of Medicine, Singapore |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Geriatric outreach to residential aged care: Embracing a dynamic approach in the COVID-19
era |
Ní Chróinín, D, Patil, et al |
Australasian Journal on Ageing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Noûs, C |
Societes Contemporaines |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Savoir et prévoir: Première chronologie de l'émergence du COVID-19 |
Noûs, C |
Societes Contemporaines |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19: La fin du sida comme modèle politique de lutte contre les épidémies
? |
Noûs, C |
Societes Contemporaines |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nursing Now and the role of nursing in the context of pandemic and current
work |
Oliveira, KKD, Freitas, et al |
Rev Gaucha Enferm |
Commentary/Editorial| Commentaire/Éditorial |
|
|
David Oliver: How not to do covid-19 comms-copy our government |
Oliver, D |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ong, CH, Ragen, et al |
European Journal of Psychological Assessment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ortiz, EI, Herrera, et al |
Colombia Medica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pagedar, NA, Seaman, et al |
Ann Otol Rhinol Laryngol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Learning from combination hiv prevention programmes to face covid-19 emerging pandemic |
Palacios, R, Mathias, et al |
Colombia Medica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Palomeque Recio, R |
Feminist Media Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pareek, P, Vishnoi, et al |
JCO global oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Management of the patient with allergic and immunological disorders in the pandemic
COVID-19 era |
Patella, V, Delfino, et al |
Clinical and Molecular Allergy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pather, S |
SAJCH South African Journal of Child Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pavelski, MD, Faverani, et al |
J Craniofac Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Trouble in the trough: how uncertainties were downplayed in the UK’s science advice
on Covid-19 |
Pearce, W |
Humanities and Social Sciences Communications |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pellikka, PA, Naqvi, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Peng, W, Li, et al |
|
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|
|
|
Pérez-García, U, Arellano-Mendoza, et al |
Dermatologia Revista Mexicana |
Commentary/Editorial| Commentaire/Éditorial |
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Peters, MDJ, Bennett, et al |
Australian Journal of Advanced Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Plüss, JD |
Transformation |
Commentary/Editorial| Commentaire/Éditorial |
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Poi, CH, Koh, et al |
Annals of the Academy of Medicine, Singapore |
Commentary/Editorial| Commentaire/Éditorial |
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Porres-Aguilar, M, Heresi, et al |
Medicina (Argentina) |
Commentary/Editorial| Commentaire/Éditorial |
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Posada-Vergara, M, Alzate-ángel, et al |
Colombia Medica |
Commentary/Editorial| Commentaire/Éditorial |
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Deep mutagenesis in the study of COVID-19: a technical overview for the proteomics
community |
Procko, E |
Expert Rev Proteomics |
Commentary/Editorial| Commentaire/Éditorial |
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Rafferty, Y |
Journal of Children's Services |
Commentary/Editorial| Commentaire/Éditorial |
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Rafiei, Y, Mello, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
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Rahman, SMM, Hossain, et al |
Bangladesh Medical Research Council bulletin |
Commentary/Editorial| Commentaire/Éditorial |
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Rai, P, Gogia, et al |
Epilepsia Open |
Commentary/Editorial| Commentaire/Éditorial |
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Safety considerations for the use of Point-Of-Care diagnostics during SARS-CoV-2 pandemic |
Raimann, FJ, Piekarski, et al |
J Clin Lab Anal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rajkhowa, A |
Pacific Journalism Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ralli, M, Cedola, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
PMC7571295; Targeting complement cascade: an alternative strategy for COVID-19 |
Ram Kumar Pandian, S, Arunachalam, et al |
3 Biotech |
Commentary/Editorial| Commentaire/Éditorial |
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Ramaswamy, S, Seshadri, et al |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Ramírez, MLO |
Colombia Medica |
Commentary/Editorial| Commentaire/Éditorial |
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|
COVID-19 Global Pandemic: Options for Management of Gynecologic Cancers |
Ramirez, PT, Chiva, et al |
Obstetrical and Gynecological Survey |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ranaei, V, Pilevar, et al |
Journal of Food Quality and Hazards Control |
Commentary/Editorial| Commentaire/Éditorial |
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|
|
EMU and the European pillar of social rights: Do (shall) the twain ever meet? |
Rasnača, Z, Theodoropoulou, et al |
Politiche Sociali |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Regidor, PA, Santos, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rehman, H, Ahmad, et al |
Arch Physiol Biochem |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Reid, J, Daniels, et al |
Communicatio |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Non-SARS-CoV-2 biomedical research in times of pandemic and post-pandemic |
Remolins, C, Chuluyan, et al |
Medicina (Argentina) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ribero, S, Caliendo, et al |
G Ital Dermatol Venereol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
2030 is tomorrow: transformative change for a mistreated mother Earth |
Richardson, JG, Erdelen, et al |
Foresight |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Construction of Meaning during a Pandemic: The Forgotten Role of Social Norms |
Rimal, RN, Storey, et al |
Health Commun |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: Most trainees have faced disruption to their training, GMC survey shows |
Rimmer, A |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ríos-Barnés, M, Lanaspa, et al |
Archivos de Bronconeumologia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Coagulopathy and COVID-19. Recommendations for a changing reality |
Riveros, D, Maymó, et al |
Medicina (Argentina) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ro, R, Khera, et al |
JAMA network open |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rojulpote, C, Gonuguntla, et al |
Colombia Medica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rouette, J, Suissa, et al |
Epidemiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Benefits, Burden, and COVID-19: A Response to Dutheil et al. (2020) |
Rubenstein, E, Kalkbrenner, et al |
J Autism Dev Disord |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rubin, EJ, Baden, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rubin, R |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Probing Mental Health Invisibilities during a Global Pandemic |
Russell, LD, St James, et al |
Health Commun |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 Pandemic Has Spurred Materials Researchers to Develop Antiviral Masks |
Sachan, D |
ACS Central Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A Land in Agony: COVID-19, Economic Collapse, Political Corruption, and a Deadly Blast |
Saliba, AN, Taher, et al |
Am J Hematol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Salum, GA, Spanemberg, et al |
Journal of psychiatric research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Samuel, K, Nickell, et al |
Journal of the Intensive Care Society |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sanchez, T, Peña, et al |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sandoval, EAP |
Revista Cubana de Medicina Militar |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19, Hypercoagulability and Cautiousness with Convalescent Plasma |
Sanfilippo, F, La Rosa, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sanjan, A, Krishnan, et al |
International Journal of Critical Illness and Injury Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33012887; Sars-cov-2 diagnostic testing alternatives for latin america |
Santaella-Tenorio, J |
Colombia Medica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sanz, AA, Rubio, et al |
International Journal of Psychology and Psychological Therapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Saran, S, Gurjar, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sarkis, J |
IEEE Engineering Management Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Satyam, A, Tsokos, et al |
Clinical Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sauer, K, Harris, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33007368; How NETosis could drive “Post-COVID-19 syndrome” among survivors |
Sawadogo, SA, Dighero-Kemp, et al |
Immunology letters |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Scheyett, A |
Social work |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Serrano, ER, Jimeno, et al |
Pediatria de Atencion Primaria |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
[Multifocal encephalitis as a neurological manifestation of COVID-19 infection] |
Serrano-Serrano, B, López-Hernández, et al |
Rev Neurol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Seybold, U |
Deutsche medizinische Wochenschrift |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shams, S, Mansoor, et al |
Asia-Pacific Journal of Oncology Nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Oncology Nursing Challenges during COVID-19 Outbreak: Precautions and Guidance |
Shankar, A, Seth, et al |
Asia-Pacific Journal of Oncology Nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Shen, X, Cai, et al |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Silberner, J |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Opportunities and challenges for social sciences in the aftermath of the COVID-19
pandemic |
Silva, KT |
Sri Lanka Journal of Social Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Silvestry, SC |
Journal of Thoracic and Cardiovascular Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Singh, NJ, Bharvee, et al |
Research Journal of Chemistry and Environment |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid 19 and access to mental health care-Need of increased
investment |
Singh, OP |
Indian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Democracy, biodiversity and more than human justice imperatives: Institutional responses
to crisis |
Skillington, T |
Social Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Smith, AE |
Journal of Democracy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Provisional case definitions for COVID-19-associated neurological disease –
Authors' reply |
Solomon, Tom, Benjamin, et al |
The Lancet Neurology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
33001431; Coronavirus variant COVID-19 pandemic: a report to seafarers |
Sossai, P, Uguccioni, et al |
International maritime health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Soundararajan, V, Sahasranamam, et al |
Journal of World Business |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sentiment urgency emotion conversion over time for business intelligence |
Soussan, T, Trovati, et al |
International Journal of Web Information Systems |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Implementation of a virtual rotation in Cardiology in times of COVID-19 |
Spaletra, P, Sigal, et al |
Medicina (Argentina) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Steben, M, Norris, et al |
Journal of Obstetrics and Gynaecology Canada |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19 Vaccine Trials and Incarcerated People - The Ethics of Inclusion |
Strassle, C, Jardas, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sukhomlin, T |
Journal of the American College of Surgeons |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Google Trends Data and COVID-19 in Europe: correlations and model enhancement are European
wide |
Sulyok, M, Ferenci, et al |
Transbound Emerg Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Analysis
of pre and post influence of covid-19 pandemic among general population |
Sumira, M, Shalini, et al |
Research Journal of Biotechnology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32997119; Managing Aortic Stenosis in the Age of COVID-19: Preparing for
the Second Wave |
Sundt, TM |
JAMA network open |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Logical Case for Love as an Ingredient in Policy Formulation After COVID-19 |
Sur, R |
Global Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32992361; Outpatient care for pregnant and puerperal women during the COVID-19 pandemic |
Surita, FGC, Luz, et al |
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Expeditious responses to COVID-19 crisis: From governmental management to laboratory
approach |
Sytwu, HK |
Biomedical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Takahari, D, Shinozaki, et al |
Int J Clin Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Thanesekaraan, V, Samaria, et al |
Journal of the Indian Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32998497; Tromboseprofylakse til pasienter med covid-19-infeksjon |
Tjønnfjord, E, Øverstad, et al |
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Teaching Innovation Grant COVID-19 Online Social Distance Teaching Project &
Virtual Event |
Tuma, LA, Stanley, et al |
Journal of Teaching in Travel and Tourism |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Van Der Leeuw, S |
Global Sustainability |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Vanegas, JCU |
Produccion y Limpia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Velamoor, V, Persad, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Viale, R |
Mind and Society |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Vieten, UM |
Social Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Viggiano, D, Lococo, et al |
Interact Cardiovasc Thorac Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Vilhelmsson, A, Mulinari, et al |
Acta Sociologica (United Kingdom) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Vitiello, P, Sica, et al |
G Ital Dermatol Venereol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
"immune Boosting" in the time of COVID: Selling immunity on Instagram |
Wagner, DN, Marcon, et al |
Allergy, Asthma and Clinical Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Clinical management of lung cancer patients during the outbreak of COVID-19 epidemic |
Wang, L, Jiang, et al |
Infectious Agents and Cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wang, Y, Tse, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Transmission of varicella-zoster-virus (VZV) in family: calls for attention during COVID-19
outbreak |
Wang, Y, Zhu, et al |
J Cosmet Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wang, Z, Fu, et al |
Biochem Soc Trans |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Aye corona!:
Experiences of an hiv nurse in a time of COVID-19 |
Watson, S |
HIV Nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Will COVID-19 pandemic finally
establish drug quality metrics? |
Wechsler, J |
Pharmaceutical Technology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wechsler, J |
BioPharm International |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Telemedicine in Oncology: Delivering on an Overdue Promise in the COVID-19 Era |
West, H |
Frontiers in Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Whitfield, M, Reed, et al |
Addiction |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Domestic violence and abuse, coronavirus, and the media narrative |
Williamson, E, Lombard, et al |
Voluntary Sector Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: Suicidal thoughts increased in young adults during lockdown, UK study finds |
Wise, J |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
On build-up of epidemiologic models—Development of a SEI3RSD model for the spread of
SARS-CoV-2 |
Wolff, M |
ZAMM Zeitschrift fur Angewandte Mathematik und Mechanik |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wu, L, Yuan, et al |
Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Biological characteristics of 2019 novel coronavirus and strategies
for clinical specimen collection |
Xia, D, Du, et al |
Chinese Journal of Laboratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Yamey, Gavin, Schäferhoff, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yen, CF, Shim, et al |
JAMA Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33004713; COVID-19 deaths can be reduced - simply and safely! |
Ylikoski, J, Markkanen, et al |
Medical gas research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zewail-Foote, M |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ziaee, V, Assari, et al |
Iranian Journal of Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Anxious immobilities: an ethnography of coping with contagion (Covid-19) in
Macau |
Zuev, D, Hannam, et al |
Mobilities |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zvizdic, Z, Vranic, et al |
Journal of pediatric surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
33012858; Melanie Saville: the end-to-end process needed for a SARS-CoV-2 vaccine |
|
Bulletin of the World Health Organization |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bulletin of the World Health Organization |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Chinese Journal of Applied Clinical Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives