Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-10-21
Good afternoon,
There are 1062 citations in today’s scan. 651 were considered primary research or review literature.
Highlights today include:
CANADA
·
Hoiland et al.
This Canadian study aimed to determine whether ABO blood groups are associated with different severities of COVID-19. A higher proportion of COVID-19 patients with blood group A or AB required mechanical ventilation, and CCRT, and had a longer ICU stay,
compared with patients with blood group O or B. Blood group A or AB also had an increased probability of requiring mechanical ventilation and CRRT after adjusting for age, sex, and presence of ≥1 comorbidity. Inflammatory cytokines did not differ between patients
with blood group A or AB vs O or B for all cytokines.
PUBLIC HEALTH INTERVENTION
·
Chae et al
investigated whether the imposition of fines for lockdown violation can mitigate the spread of COVID-19 in Germany. A city
that introduced fines on March 20 reduced the Rt by a further 0.32 (95% CI = −0.46, −0.18; P < .001) and decreased the growth rate in confirmed cases by an additional 6 percentage points (95% CI = −0.11,
−0.02; P = .005) compared with the control group. Lockdowns may work better when governments introduce penalties against those who ignore them.
·
Herbet et al. field tested a prototype smart handwashing station deployed in
an Australian school for 10 days during the COVID-19 pandemic. It was used 1138 times, and there was no COVID-19 transmission at the school during the testing.
This study demonstrates that a personalized feedback approach using technology can successfully be implemented at a school and can provide a platform to improve hand hygiene among school-aged children.
·
Zhao et al
conducted a comparative study on the epidemiological characteristics and transmission dynamics for the COVID-19 and severe acute respiratory syndrome (SARS) outbreaks in mainland China. Compared with SARS, COVID-19 affected more extensive areas within
a shorter time and had higher attack rate. SARS-CoV-2 was more likely to infect older people while SARS-CoV was more likely to infect young adults. The case fatality rate (CFR) of either disease increased with age, but the CFR of COVID-19 was significantly
lower than that of SARS (5.6% vs 6.4%). The trajectory of effective reproduction number dynamically changed in relation to interventions, which fell below 1 within 2 months for COVID-19 and within 5.5 months for SARS.
TRANSMISSION
·
Chau et al report a superspreading event of SARS-CoV-2 involving 18 individuals initiated at a bar in Vietnam with evidence of
symptomatic and asymptomatic transmission. Crowds in enclosed indoor settings with poor ventilation may be considered at high risk for transmission.
·
Kutter et al
studied transmission of SARS-CoV and SARS-CoV-2 through the air between ferrets over more than a meter distance. Both viruses caused a robust productive respiratory tract infection resulting in transmission of SARS-CoV-2 to two of four indirect recipient
ferrets and SARS-CoV to all four. A control pandemic A/H1N1 influenza virus also transmitted efficiently. Serological assays confirmed all virus transmission events.
·
Atrubin et al
report about an outbreak of COVID-19 associated with a recreational hockey game in Florida in June 2020. 5 days after the game, 15 persons (14 of the 22 players and a rink staff member) experienced signs and symptoms
compatible with COVID-19; 13 of the 15 ill persons had positive laboratory test results. The ice rink provides a venue that is likely well suited to COVID-19 transmission as an indoor environment where deep breathing occurs, and persons are in close proximity
to one another.
IMMUNOLOGY
·
Lu et al
evaluate the nucleic acid and antibody test results of patients with Coronavirus Disease 2019 (COVID-19) in China. Of 73 patients aged 11–82, 65 (89.0%) patients had IgM or IgG antibodies against SARS-CoV-2. Within 2 months, 4 patients who previously
tested positive for IgM or IgG antibodies tested negative.
·
Aydillo et al
profiled the early humoral immune response against SARS-CoV-2 on hospitalized
COVID-19 patients, and quantify levels of pre-existing immunity to OC43, HKU1 and 223E seasonal
coronaviruses. All patients developed antibodies against SARS-CoV-2 spike and nucleoprotein, with peak induction at day 7
post hospitalization. However a negative correlation was found between antibody memory boost to human
coronaviruses and induction of IgG and IgM against SARS-CoV-2 spike. Our findings provide evidence of immunological imprinting
that determine the antibody profile to COVID-19 patients in an original antigenic sin fashion.
·
Stromer, et al.
studied kinetics of neutralizing antibodies and immunoglobulin G (IgG) against the nucleo (N) or spike (S) proteins of severe acute respiratory syndrome coronavirus type2 (SARS-CoV-2) in patients up to 165 days after PCR diagnosis of infection. IgG kinetics,
avidities, and virus-neutralizing capacities were recorded over up to 165 days in eleven patients and five individuals from routine diagnostics. The titers were relatively low, suggesting that sustained humoral immunity is uncertain, especially after outpatient
SARS-CoV-2 infection.
EPIDEMIOLOGY
·
Yang et al
conducted a population-based cohort study to investigate the association between pregnant women with COVID-19 and the risk of adverse birth outcomes in China. Compared to pregnant women without COVID-19, pregnant women with a confirmed COVID-19 diagnosis
had an increased risk of preterm birth and cesarean section. Among these newborns that were born to mothers with confirmed COVID-19, none were SARS-CoV-2 positive or had abnormal CT results.
·
Krieger et al
analyzed age-standardized death rates in Massachusetts by weekly time intervals, comparing rates for January 1 to May 19, 2020, with the corresponding historical average for 2015 to 2019 stratified by zip code social metrics. Mortality rate ratios were
2.2 and 2.7 for the lowest and highest zip code tabulation area (ZCTA) poverty categories, respectively. Similarly, rate ratios were significantly elevated for the highest versus lowest quintiles with respect to household crowding, racialized economic segregation,
and percentage population of color.
·
Niles et al describe the first large-scale observational study investigating the associations between ABO group/Rh types with SARS-CoV-2 positivity, by major
race/ethnicity. The SARS-CoV-2 positivity rate was 38% higher in Rh+ patients (12.7%) than in Rh- patients (9.2%). The SARS-CoV-2 positivity rate was also significantly higher among type O patients. Findings demonstrated that Rh positivity, independent of
ABO blood group and race/ethnicity, was a statistically significant risk factor for SARS-CoV-2 positivity. Type O blood is slightly protective against SARS-CoV-2 positivity once race/ethnicity has been considered.
·
Smati, et al.
assessed the relationship between BMI classes and early COVID‐19 prognosis in inpatients with type 2 diabetes (T2D). Clinical characteristics and COVID‐19‐related outcomes (i.e. intubation for mechanical ventilation [IMV], death and discharge by day
7 [D7]) were analyzed according to BMI status. After multivariable adjustment, primary outcome by D7 was significantly associated with obesity in patients under 75 years, while such association was no longer found in those over 75 years.
·
He et al.
Based on patient data of 9120 confirmed cases in China, we calculated the variation of the individual infectiousness. This suggests that the dispersion in the individual infectiousness is probably low, thus COVID-19
infection is relatively easy to sustain in the population and more challenging to control. Instead of focusing on the much fewer super spreading events, we also need to focus on almost every case to effectively reduce transmission.
·
Borro et al
modelled the role of HVAC systems in the diffusion of the contagion through Computational Fluid Dynamics (CFD) simulations of cough at the “Bambino Gesù” Vatican State Children’s Hospital. The proper use of Local Exhaust Ventilation systems (LEV) simulated
in the hospital room was associated to a complete reduction of infected droplets spreading from the patient’s mouth in the first 0.5 seconds following the cough event. In the hospital room, the use of LEV system completely reduced the η index computed for
the patient hospitalized at the bed next to the spreader, with a decreased possibility of contagion.
CLINICAL DATA
·
Alahmad et al. Describe a study in Kuwait looking at the association between fasting blood glucose and morbidity and mortality of COVID-19. A
nonlinear estimation showed a steep slope until about 10 mmol/L before flattening. Results argue for strict glucose management on admission. Even a small incremental increase within the normal range of FBG was associated with a substantial increase in risk
of ICU admission for COVID-19 patients.
·
Harris et al
This point prevalence study reveals ⅓ of patients in a London inpatient rehabilitation unit were found to be infected with SARS-CoV-2,
but asymptomatic (n=15/45). Notably, a novel serological test for antibodies against the receptor binding domain of SARS-CoV-2
showed 100% of our asymptomatic cohort remained seropositive between 3 to 6 weeks post-diagnosis.
ANIMAL MODEL
·
Aid et al. Describe the vascular disease and thrombosis caused by SARS-CoV-2 in macaques. The observed macrophage infiltrates in the
lungs, upregulation of the proinflammatory cytokines, ISGs, complement and coagulation cascades. And observe that the infection led to endothelial damage and thrombosis. Thus suggesting a critical interaction between the inflammatory and thrombosis pathways
that lead to SARS-CoV-2 induced vascular disease.
DIAGNOSTICS
·
Skittrall, et al.
estimates test specificity and positive predictive value to evaluate the impact of confirmatory testing, and to improve clinical diagnosis, epidemiological estimation and interpretation of vaccine trials. Nucleic acid amplification testing for SARS-CoV-2
is highly specific. Nevertheless, when prevalence is low a significant proportion of initially positive results fail to confirm and confirmatory testing substantially reduces false positive detections. Omitting additional testing in samples with higher prior
detection probabilities focuses testing where clinically impactful and minimises delay.
THERAPEUTICS
·
Annweiler et al
determine whether bolus vitamin D3 supplementation taken during or just before COVID-19 was effective in improving survival among frail elderly nursing-home residents with COVID-19. 82.5% of participants in the Intervention group survived COVID-19, compared
to only 44.4% in the Comparator group. Kaplan-Meier distributions showed that Intervention group had longer survival time than Comparator group (log-rank P = 0.002). Finally, vitamin D3 supplementation was inversely associated with Ordinary Scale for Clinical
Improvement score for COVID-19. In conclusion, bolus vitamin D3 supplementation during or just before COVID-19 was associated in frail elderly with less severe COVID-19 and better survival rate.
·
Cai et al
tested the in vitro inhibitory activity of griffithsin (GRFT) against infection of pseudotyped and live SARS-CoV-2 infection, in order to repurpose the application of GRFT as a potential prophylactic or therapeutic to prevent or treat COVID-19. And found
that GRFT is highly effective in inhibiting the pseudotyped and live SARS-CoV-2 infection by binding to the glycosylation sites in the S1 subunit, possibly the RBD, of SARS-CoV-2 S protein. And combining GRFT with the pan-CoV fusion inhibitor EK1 exhibited
excellent synergistic effect against SARS-CoV-2 pseudovirus infection.
PUBLIC HEALTH RESPONSE
·
Goldman et al
investigate predictors associated with global caregivers' intent to vaccinate their children against COVID-19. 65% (n = 1005) of caregivers reported that they intend to vaccinate their child
against COVID-19, once a vaccine is available. An
increased intended uptake was associated with children that were older, children with no chronic illness, when fathers completed the survey, children up-to-date on their vaccination schedule, recent history of vaccination against
influenza, and caregivers concerned their child had COVID-19 at the time of survey. The most common reason reported by caregivers intending to vaccinate was to protect their child (62%), and the most common reason reported
by caregivers refusing vaccination was the vaccine's novelty (52%).
·
Czeisler et al.,
conducted a survey among U.S. adults aged ≥18 years during June 24-30, 2020. Overall, 85.2% of respondents reported always or often engaging in hand hygiene following contact with high-touch public surfaces such as shopping carts,
gas pumps, and automatic teller machines (ATMs). Respondents who were male (versus female) and of younger age reported lower handwashing and hand sanitizing rates, as did respondents who reported lower concern about their own infection with SARS-CoV-2 and
respondents without personal experience with COVID-19.
·
Galasso et al. Authors set out to assess the effectiveness of public health policies that hinge on generalized public obedience in eight
WHO countries. Gender differences in attitudes and behavior are sizable in all countries. They are accounted for neither by sociodemographic and employment characteristics nor by psychological and behavioral factors.
·
Wilson et al
aimed to identify factors that influence exposure to COVID-19 among young adults in the United States. Characteristics of COVID-19 cases and drivers of behaviors in this age group were examined. In 30 key informant interviews, most interviewees reported
exposure to misinformation, conflicting messages, or opposing views about the need for and effectiveness of masks. Thirteen young adults described social or peer pressure to not wear a mask and perceived severity of disease outcome for themselves as low but
high for loved ones at risk.
·
Hammoud et al. investigated
the impact of physical distancing measures due to COVID-19 on the sexual behavior of gay and bisexual men in Australia. Most participants (88.3%) reported sex with other men during the 6 months before COVID-19.
Of the 587 men (62.4%) who reported sex with casual partners before COVID-19, 93 (15.8%) continued to do so in the period since COVID-19
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura
Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Alex Gilbert, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
|
PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
A prolonged course of COVID-19 in a person with dementia |
Aakhus, E, Finbråten, et al |
Tidsskr Nor Laegeforen |
Clinical data| Données cliniques |
case report: Ten days later he developed more severe symptoms. PCR test for SARS-CoV-2 was positive. Over the following
two months his clinical state fluctuated, from almost symptom-free days to being bedridden and assessed as potentially terminal. After the initial positive test, he had three consecutive negative tests, before he again tested positive for SARS-CoV-2. Uncertainty
as to whether the patient remained contagious resulted in isolation of the patient for over two months. |
|
Abe, T, Ikeda, et al |
Qjm |
Clinical data| Données cliniques |
case report of an 80 year old man whose nasopharyngeal swab at day 111 still had culturable virus despite the most symptoms having resolved after 3 months.
, the patient developed neutralizing antibodies by a microtiter method. We tested but did not isolate SARS-CoV-2 in samples of saliva, urine, blood, or stool. Patients with ongoing symptoms of COVID-19, long-haulers, could be chronically infected with COVID-19,
although they might be incapable of transmission. |
|
|
PMC7546239; Comparing the accuracy of several network-based COVID-19 prediction
algorithms |
Achterberg, MA, Prasse, et al |
Int J Forecast |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Researchers from various scientific disciplines have attempted to forecast the spread of the Coronavirus Disease 2019 (COVID-19). The proposed epidemic
prediction methods range from basic curve fitting methods and traffic interaction models to machine-learning approaches. If we combine all these approaches, we obtain the Network Inference-based Prediction Algorithm (NIPA). In this paper, we analyse a diverse
set of COVID-19 forecast algorithms, including several modifications of NIPA. Among the diverse set of algorithms that we evaluated, original NIPA performs best on forecasting the spread of COVID-19 in Hubei, China and in the Netherlands. In particular, we
show that network-based forecasting is superior to any other forecasting algorithm. |
|
Adibellİ, D, SÜmen, et al |
Child Youth Serv Rev |
Public Health response| Interventions de santé publique |
Turkey, survey of children: The coronavirus outbreak causes fear and anxiety in society. Parents reported that their children gained weight during the
pandemic. |
|
|
Modelling COVID 19 in the Basque Country from introduction to control measure response |
Aguiar, M, Ortuondo, et al |
Sci Rep |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Basque Modelling Task Force, BMTF. Here we describe the efforts and challenges to develop a flexible modeling framework able to describe the dynamics observed
for the tested positive cases, including the modelling development steps. hort and longer-term predictions were tested with good results adjusted to the available epidemiological data. We have shown that the partial lockdown measures were effective and enough
to slow down disease transmission in the Basque Country. |
|
Ahmetaj-Shala, B, Vaja, et al |
JACC Basic Transl Sci |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
Vascular/cardiovascular inflammation and thrombosis occur in severe COVID-19. Advancing age is the most significant
risk factor for severe COVID-19. Using transcriptomic databases, we found: (i) cardiovascular tissues/endothelial cells express putative genes for SARS-CoV-2 infection including ACE2 and BSG, (ii) SARS-CoV-2 receptor pathways, ACE2TMPRSS2 and BSG/PPIB(A) polarise
to lung/epithelium and vessel/endothelium respectively, (iii) expression of host genes are relatively stable with age and (iv) notable exceptions are ACE2 which decreases with age in some tissues and BSG which increases with age in endothelial cells, suggesting
that BSG expression in the vasculature may explain the heightened risk of severe disease with age. |
|
|
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques |
Aid, M, Busman-Sahay, et al |
Cell |
Clinical data| Données cliniques Coronavirology| Coronavirologie Animal model | Modèle animal |
Clinical features that drive SARS-CoV-2 pathogenesis in humans include inflammation and thrombosis, but the mechanistic
details underlying these processes remain to be determined. In this study, we demonstrate endothelial disruption and vascular thrombosis in histopathologic sections of lungs from both humans and rhesus macaques infected with SARS-CoV-2. To define key molecular
pathways associated with SARS-CoV-2 pathogenesis in macaques, we performed transcriptomic analyses of bronchoalveolar lavage and peripheral blood and proteomic analyses of serum. We observed macrophage infiltrates in lung and upregulation of macrophage, complement,
platelet activation, thrombosis, and proinflammatory markers, including C-reactive protein, MX1, IL-6, IL-1, IL-8, TNFα, and NF-κB. These results suggest a model in which critical interactions between inflammatory and thrombosis pathways lead to SARS-CoV-2-induced
vascular disease. Our findings suggest potential therapeutic targets for COVID-19. |
|
Akan, S, Ediz, et al |
Int J Clin Pract |
Clinical data| Données cliniques |
Every effort should be made to administer intravesical BCG treatment in high-risk high-risk non-muscle-invasive bladder
cancer (NMIBC) patients even during the pandemic period. Neutrophil/lymphocyte ratio was significantly higher in the COVID-19 positive group (p<0.05). COVID-19 positivity was higher in age groups 50-64 (6.6%) and 65-80 (5.8%) years than that in similar age
groups of the normal population. |
|
|
PMC7553367; Structure-Based Design of Novel
Peptidomimetics Targeting the SARS-CoV-2 Spike Protein |
Alagumuthu, M, Rajpoot, et al |
Cell Mol Bioeng |
Coronavirology| Coronavirologie |
In the current study, we identified potential peptidomimetics against the SARS-CoV-2 spike protein. Top scoring peptidomimetics
were found to bind at the ACE2 binding site of the receptor-binding domain (RBD) of SARS-CoV-2 spike protein. |
|
Fasting Blood Glucose and COVID-19 Severity: Nonlinearity
Matters |
Alahmad, B, Al-Shammari, et al |
Diabetes care |
Clinical data| Données cliniques |
Kuwait: We comprehensively examined different ways of modeling FBG to assess the risk of being admitted to the intensive
care unit (ICU). For 417 patients, the conventional linear, dichotomous, and categorical approaches to modeling FBG missed key trends in the exposure-response relationship. A nonlinear estimation showed a steep slope until about 10 mmol/L before flattening.
Our results argue for strict glucose management on admission. Even a small incremental increase within the normal range of FBG was associated with a substantial increase in risk of ICU admission for COVID-19 patients. |
|
Alcover, CM, Rodríguez, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
This study aims to explore the role played by group membership and social and personal identities as coping resources
to face the experience of the COVID-19 confinement and radical disruption of social, work, family and personal life in a sample of 421 people who have experienced a month of strict confinement in the Region of Madrid. Our results show that identity-resources
(membership continuity/new group memberships, and personal identity strength) are positively related to process-resources (social support and perceived personal control), and that both are related to better perceived mental health, lower levels of anxiety
and depression, and higher well-being (life satisfaction and resilience) during confinement. |
|
|
Alduraywish, AA, Srivastava, et al |
Int J Environ Res Public Health |
Healthcare Response | Réponse des soins de santé |
The present study aims to assess the knowledge and attitude of HCPs towards COVID-19 in the Kingdom of Saudi Arabia
(KSA). A cross-sectional study 1040 HCWs, considering the "good" level of the respective domain, the HCPs have displayed better knowledge (48.2%) over attitude (33.8%). Female (aOR: 1.55; 95%CI: 1.15-2.09; p = 0.004), Diploma degree (aOR: 2.51; 95%CI: 1.64-3.83;
p < 0.001), 7-10 years' experience (aOR: 1.47; 95%CI: 1.01-2.15; p = 0.045) were at higher risk of having inadequate knowledge compared to their contemporaries. |
|
|
Alfageme, Marta, Plaza, et al |
Research Square prepub |
Clinical data| Données cliniques |
The purpose of our retrospective study was to evaluate the prevalence of asymptomatic DVT in lower limbs in critically
ill COVID-19 patients (n=23) with severe respiratory failure and high levels of D-dimer by bedside Doppler ultrasound (DU). DVT was diagnosed in 14 cases (60.87%), 5 in proximal venous territory and 9 in infrapopliteal veins. CTPA was performed in 6 patients
and all of them showed acute pulmonary embolism (APE) at segmental or subsegmental branches of pulmonary arteries. |
|
|
Aliberti, MJR, Covinsky, et al |
Age Ageing |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Cohort 1,428 consecutive inpatients aged ≥50 years.: This study aimed to determine the usefulness of adding a rapid
vulnerability screening to an illness acuity tool to predict mortality in hospitalised COVID-19 patients. PRO-AGE score (0-7; higher = worse). The incidence of 60-day mortality ranged from 22% to 69% across the quartiles of modified PRO-AGE. In adjusted
analysis, compared with modified PRO-AGE scores 0-1 ("lowest quartile"), the hazard ratios (95% CI) for 60-day mortality for modified PRO-AGE scores 2-3, 4, and 5-7, were 1.4 (1.1-1.9), 2.0 (1.5-2.7), and 2.8 (2.1-3.8), respectively. The modified PRO-AGE predicted
different mortality risk levels within each stratum of NEWS and improved the discrimination of mortality prediction models. |
|
|
What Explains Temporal and Geographic Variation in the Early Us Coronavirus Pandemic? |
Allcott, Hunt, Boxell, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie |
We provide new evidence on the drivers of the early US coronavirus pandemic. We combine an epidemiological model of
disease transmission with quasi-random variation arising from the timing of stay-at-home orders to estimate the causal roles of policy interventions and voluntary social distancing. We estimate significant impacts of policy and social distancing responses,
but we show that the magnitude of policy effects is modest, and most social distancing is driven by voluntary responses. Moreover, we show that neither policy nor rates of voluntary social distancing explain a meaningful share of geographic variation. The
most important predictors of which cities were hardest hit by the pandemic are exogenous characteristics such as population and density |
|
Allenbach, Y, Saadoun, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
French single-center prospective cohort study evaluated 152 patients with positive severe acute respiratory syndrome
coronavirus 2 . Predictive factors of intensive care unit (ICU) transfer or death at day 14 (D14), of being discharge alive and severe status at D14 (remaining with ventilation, or death) were evaluated in multivariable logistic regression models. The probability
of ICU transfer or death was 32% (47/147) (95% CI 25-40). Older age (OR 2.61, 95% CI 0.96-7.10), poorer respiratory presentation (OR 4.04 per 1-point increment on World Health Organization (WHO) clinical scale, 95% CI 1.76-9.25), higher CRP-level (OR 1.63
per 100mg/L increment, 95% CI 0.98-2.71) and lower lymphocytes count (OR 0.36 per 1000/mm3 increment, 95% CI 0.13-0.99) were associated with an increased risk of ICU requirement or death. |
|
|
Rotational thromboelastometry results are associated with care level in COVID-19 |
Almskog, LM, Wikman, et al |
J Thromb Thrombolysis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The primary aim of this study was to test whether rotational thromboelastometry (ROTEM) at admission indicates hypercoagulopathy
and predicts the disease severity, assessed as care level, in COVID-19 patients. The study was designed as a prospective, observational study where COVID-19 patients over 18 years admitted to hospital were eligible for inclusion. Our results suggest that hypercoagulopathy
is present early in patients with mild to moderate disease, and more pronounced in severe COVID-19 pneumonia. Non-O blood types were not overrepresented in COVID-19 positive patients. ROTEM variables showed hypercoagulopathy at admission and this pattern was
more pronounced in patients with increased disease severity. |
|
Alotaibi, N, Almutairi, et al |
J Community Health |
Public Health response| Interventions de santé publique |
We aimed to estimate how the knowledge of and compliance with safe distancing measures affected the progression of
the COVID-19 pandemic in Saudi Arabia during Holy Ramadan. A cross-sectional survey 24th of April to 22nd May to coincide with Ramadan. A significant difference between males and females was observed in answering questions about committing to: not attending
gatherings, keeping a safe distance, not making physical contact, and staying at home during partial lockdown. In general, participants in our study demonstrated excellent adherence to all social distance measures, considered essential for limiting the spread
and progression of COVID-19. However, attitudes regarding reduced physical contact was poor in the Makkah region, which necessitates greater efforts to educate and inform people about the associated risks. |
|
|
Alrubaiee, GG, Al-Qalah, et al |
BMC Public Health |
Healthcare Response | Réponse des soins de santé |
To protect and enhance the ability of HCPs to perform their role in responding to COVID-19, healthcare authorities
must help to alleviate the level of stress and anxiety amongst HCPs and the community. The results indicated that from the 1231 HCPs participating in this study, . The results further revealed that the majority of respondents had adequate knowledge, optimistic
attitude, moderate level of anxiety, and high-performance in preventive behaviours, 69.8, 85.10%, 51.0 and 87.70%, respectively, towards COVID-19. |
|
|
Al-Tammemi, Ala |
Research Square prepub |
Public Health response| Interventions de santé publique |
A cross-sectional study Objectives This study aimed to assess and explore (i) The levels of psychological distress
and its correlates (ii) Motivation for distance learning (iii) Coping activities and pandemic related concerns, among university students in Jordan in the midst of COVID-19 pandemic. oncerning distress severity, most of respondents were regarded as having
severe psychological distress (n=265, 69.5%). 209 students (54.9%) reported that they had no motivation for distance learning. Ordinal logistic regression revealed a significant correlation between distress severity and many predictors. Among the predictors
that were found to act as a protective factors against higher levels of distress included older age (aOR=0.64, P=0.022; 95%CI: 0.44 - 0.94) , and having a strong motivation for distance learning (aOR=0.10, P=0.048 ; 95% CI: 0.01 - 0.96).In contrary, being
a current smoker (aOR=1.99, P=0.049 ; 95%CI: 1.10 - 3.39), and having no motivation for distance learning (aOR=2.49, P=0.007; 95% CI: 1.29 - 4.80) acted as risk factors for having higher levels of psychological distress among the students . |
|
|
Alviset, S, Riller, et al |
PLoS One |
Clinical data| Données cliniques |
This single centre retrospective observational cohort study took place in a French hospital 27th March to 23rd April.
Consecutive patients who had respiratory failure or were unable to maintain an SpO2 > 90%, despite receiving 10-15 l/min of oxygen with a non-rebreather mask, were treated by continuous positive airway pressure (CPAP) unless the ICU physician judged that immediate
intubation was indicated. CPAP was initiated in 49 patients and performed out of ICU in 41 (84%). Median age was 65 years (IQR = 54-71) and 36 (73%) were men. Median respiratory rate before CPAP was 36 (30-40) and median SpO2 was 92% (90-95) under 10 to 15
L/min oxygen flow. Median duration of CPAP was 3 days (IQR = 1-5). Reasons for discontinuation of CPAP were: intubation in 25 (51%), improvement in 16 (33%), poor tolerance in 6 (12%) and death in 2 (4%) patients. |
|
|
Al-Wahaibi, K, Al-Wahshi, et al |
SN Compr Clin Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Oman: Adult patients with laboratory-confirmed COVID-19 requiring hospitalization in participating centers between
March and June 2020 were included. Mortality and clinical outcomes in patients with and without cardiac injury were compared. In comparison with patients without cardiac injury, patients with cardiac injury were older (59 33-89] vs 47 22-94] years; P < 0.0001)
and had more co-morbidities and cardiovascular (CV) risk factors (hypertension in 61.3% vs 24.1%; P < 0.0001, chronic heart failure in 16.1% vs 0%; P < 0.00001, diabetes mellitus 54.8% vs 31.3%; P 0.015, COPD/asthma 19.4% vs 3.6%; P 0.002); more patients with
cardiac injury required invasive mechanical ventilation (77.4% vs 38.4%; P 0.00012). Complications were more prevalent in patients with cardiac injury than those without cardiac injury and included acute respiratory distress syndrome (87% vs 42.9%; P < 0.00001),
acute kidney injury (67.7% vs 11.6%; P < 0.00001), and anemia (38.7% vs 3.6%;P < 0.00001). The need for renal replacement therapy was also higher in patients with cardiac injury (48.4% vs 3.6%; P < 0.00001). Noticeably, patients with cardiac injury had higher
mortality than those without cardiac injury (53.3% vs 7.1%; P < 0.00001). |
|
|
Aly, MM, Elchaghaby, et al |
BDJ Open |
Healthcare Response | Réponse des soins de santé |
This study aimed to evaluate the fear of infection among Egyptian dentists practicing during the current coronavirus
disease 2019 (COVID-19) pandemic and to explore the dentist's knowledge about guidelines to fight the virus and to assess various modifications in dental practice. 216 dentists completed the survey. A total of 200 (92.6%) dental professionals were afraid
of becoming infected with COVID-19 while 196 (90.7%) became anxious to treat patients showing suspicious symptoms |
|
|
Vitamin D and survival in COVID-19 patients: A quasi-experimental study |
Annweiler, C, Hanotte, et al |
J Steroid Biochem Mol Biol |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The objective of this quasi-experimental study was to determine whether bolus vitamin D3 supplementation taken during
or just before COVID-19 was effective in improving survival among frail elderly nursing-home residents with COVID-19. Sixty-six residents with COVID-19 from a French nursing-home were included in this quasi-experimental study. The Intervention (n = 57; mean ± SD,
87.7 ± 9.3years; 79%women) and Comparator (n = 9; mean,87.4 ± 7.2years; 67%women) groups were comparable at baseline, as were the COVID-19 severity and the use of dedicated COVID-19 drugs. The mean follow-up time was 36 ± 17days. 82.5% of participants in the
Intervention group survived COVID-19, compared to only 44.4% in the Comparator group (P = 0.023). The full-adjusted hazard ratio for mortality according to vitamin D3 supplementation was HR = 0.1195% CI:0.03;0.48],P = 0.003. Kaplan-Meier distributions showed
that Intervention group had longer survival time than Comparator group (log-rank P = 0.002). Finally, vitamin D3 supplementation was inversely associated with Ordinary Scale for Clinical Improvement score for COVID-19 (β=-3.8495%CI:-6.07;-1.62], P = 0.001).
In conclusion, bolus vitamin D3 supplementation during or just before COVID-19 was associated in frail elderly with less severe COVID-19 and better survival rate. |
|
Ansumali, S, Kaushal, et al |
Annu Rev Control |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this paper, we use Lyapunov theory to establish the global asymptotic stability of the SAIR model, both without
and with vital dynamics. Then we develop compartmental SAIR models to cater to the migration of population across geographic regions, and once again establish global asymptotic stability. Next, we go beyond long-term asymptotic analysis and present methods
for estimating the parameters in the SAIR model. We apply these estimation methods to data from several countries including India, and demonstrate that the predicted trajectories of the disease closely match actual data. We show that "herd immunity" (defined
as the time when the number of infected persons is maximum) can be achieved when the total of infected, symptomatic and asymptomatic persons is as low as 25% of the population. Previous estimates are typically 50% or higher. We also conclude that "lockdown"
as a way of greatly reducing inter-personal contact has been very effective in checking the progress of the disease. |
|
|
Mental health of medical personnel during the COVID-19 pandemic |
Antonijevic, J, Binic, et al |
Brain Behav |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to explore the mental health status of medical personnel in Serbia during the pandemic
by assessing stress levels, symptoms of anxiety, and depression. This cross-sectional study was conducted as an online-based survey, in the period from 8 April to 14 April 2020. A total of 1678 participants completed the survey, with a mean age of 40.38 ±
10.32 years, of which 1,315 (78.4%) were women, and 363 (21.6%) were men. Out of these, 684 (40.8%) participants were medical personnel, and 994 (59.2%) were people of other professions. Frontline medical personnel reported higher scores on all measurement
tools than second-line medical personnel (e.g., mean PSS scores: 19.12 ± 5.66 versus 17.53 ± 5.71; p = .006; mean GAD-7 scores: 8.57 ± 6.26 versus 6.73 ± 5.76; p = .001; mean BDI-IA scores: 9.25 ± 8.26 versus 7.36 ± 7.28; p = .006). Binary logistic regression
showed that the probability of developing more severe anxiety symptoms doubles in frontline medical personnel. |
|
Araç, S, Dönmezdil, et al |
Sao Paulo Med J |
Healthcare Response | Réponse des soins de santé |
To examine psychiatric disorders such as anxiety, depression and sleep disorders among healthcare professionals working
in an emergency department and a COVID-19 clinic. Cross-sectional study including healthcare professionals in the emergency department and other units serving patients with COVID-19, of a training and research hospital in Turkey. 210 volunteers, including
105 healthcare professionals in the emergency department and 105 healthcare professionals working in other departments rendering services for COVID-19 patients, were included in this study. The perceived stress levels and Pittsburg Sleep Quality Index (PSQI)
subscores were found to be significantly higher among the volunteers working in the emergency department than among those in other departments. The risk of development of anxiety among women was 16.6 times higher than among men. Healthcare professionals on
the frontline need systematic regular psychosocial support mechanisms. |
|
|
Arambepola, Carukshi, Wickramasinghe, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A retrospective study was conducted using secondary data extracted from all laboratory-confirmed patients admitted
to the three main state-sector hospitals in Sri Lanka from 11 March to 7 April 2020. The case series comprised 146 discharges and six deaths. Majority were males (63.2%); mean age of 40.9 (SD=17.9); and symptomatic (72.4%). Sixty-one (40.1%) had co-morbidities,
the commonest being diabetes (20.4%) and hypertension (17.8%). Mild (93.4%), severe (2.6%) and critical (4.0%) disease outcomes were noted. Disease severity was significantly higher with older age (p=0.037), co-morbidities (p=0.026); and higher white-cell
(p=0.045) and lymphocyte (p=0.043) counts; but not with being symptomatic (p=0.683). The commonest symptoms were fever (62.5%), dry cough (48.0%) and sore throat (26.9%). The median duration (IQR) was 3.0 days (1.0-5.0) and 18.0 (15.0-29.5), respectively before
and during hospitalization. In contrast to high-risk countries, the younger age and milder disease portrayed in local patients reflect the success of early response to the pandemic in Sri Lanka. However, the factors determining disease fatality remain the
same as in other countries. |
|
|
Acute Meningoencephalitis as Initial Presentation of SARS-CoV-2 Infection in
Pediatrics |
Arango Ferreira, C, Correa-Roda, et al |
Pediatr Infect Dis J |
Clinical data| Données cliniques |
Present a COVID-19 case involving a 5-month-old infant presented to the emergency department with 4 days of fever,
vomiting, loose stools, cough, without respiratory distress. Clinical evaluation revealed a bulging anterior fontanel, neck stiffness, and excessive irritability. Cerebrospinal fluid analysis was abnormal with high proteins (164.4 mg/dL), normal glucose (59
mg/dL), and elevated white cells (22 cells/μL), with 12 cells/μL neutrophils, 10 cells/μL monocytes, 0 erythrocytes. Two days after admission, the child presented with obnubilation and 3 episodes of generalized seizures. Phenobarbital was initiated. A cerebral
CT scan was normal. Bleeding times were prolonged. Considering possible multisystem inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection, a single dose of intravenous immunoglobulin of 2 g/kg was administered. Complete resolution of neurologic
compromise was accomplished. With the present pandemic, acute meningoencephalitis suggestive of Enterovirus infection can be the initial presentation of COVID-19 in pediatrics, and physicians should be aware and familiar with this clinical presentation. |
|
Assayag, E, Tsessler, et al |
Eur J Ophthalmol |
Healthcare Response | Réponse des soins de santé |
We aimed to assess the utilization of telemedicine by oculoplastics specialists worldwide during the COVID-19 pandemic.
A 13-item survey was distributed internationally to practicing oculoplastic surgeons. Collected data included demographics, clinical practice variables and perceptions regarding telemedicine. The questionnaire was completed by 70 oculoplastic surgeons (54.3%
male, mean age 47.3 years, median experience 10 years) from eight countries, practicing in various clinical settings (50.0% hospitals, 45.7% private clinics, 4.3% community clinics). Most respondents reported telemedicine to be an effective tool for oculoplastic
consultations (67.1%, p = 0.004), while only 12.8% (p < 0.00001) had incorporated this modality into clinical practice prior to the pandemic. Even though a vast majority (98.6%) of participants had limited outpatient activity, most (55.7%) felt unprotected
from the virus. Telemedicine had been incorporated by 70.5% (p = 0.001) of respondents during the COVID-19 pandemic, whereas most (57.1%) predicted continued use of the modality. |
|
|
Performance evaluation of the SAMBA II SARS-CoV-2 Test for point-of-care detection of
SARS-CoV-2 |
Assennato, SM, Ritchie, et al |
J Clin Microbiol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Inclusivity and specificity of the SAMBA II SARS-CoV-2 Test was determined by both in silico analyses of the primers
and probes and wet testing. The SAMBA II SARS-CoV-2 Test was evaluated for performance characteristics. Clinical performance was evaluated in residual combined throat/nose swabs and compared to the Public Health England real-time PCR assay targeting the RdRp
gene. The SAMBA II SARS-CoV-2 Test has an analytical sensitivity of 250 cp/mL detecting two regions of the genome (Orf1ab and N). The clinical performance was evaluated in 172 residual combined nose/throat swabs provided by the Clinical Microbiology and Public
Health Laboratory, Addenbrooke's Hospital, Cambridge (CMPHL), which showed an estimated positive percent agreement of 98.9% (95% CI: 93.83-99.97) negative percent agreement of 96.4% (95%CI: 89.92-99.26) compared to testing by CMPHL. The data shows that the
SAMBA II SARS-CoV-2 Test performs equivalently to the centralised testing methods with shorter turnaround time of 86-101 minutes). Point of care testing, such as SAMBA, should enable rapid patient management and effective implementation of infection control
measures |
|
An Outbreak of COVID-19 Associated with a Recreational Hockey Game - Florida, June
2020 |
Atrubin, D, Wiese, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Transmission |
On June 16, 2020, a recreational ice hockey game was played at an ice rink in the Tampa Bay, Florida, metropolitan
area. Teams A and B, each consisting of 11 players (typically six on the ice and five on the bench at any given time), included men aged 19-53 years. During the 5 days after the game, 15 persons (14 of the 22 players and a rink staff member) experienced signs
and symptoms compatible with coronavirus disease 2019 (COVID-19)*; 13 of the 15 ill persons had positive laboratory test results indicating infection with SARS-CoV-2, the virus that causes COVID-19. Widespread transmission of SARS-CoV-2 has been documented
at a choir practice (1) and at meat processing plants (2,3); however, apart from an outbreak involving 57 infected dancers that has been linked to high-intensity fitness dance classes in South Korea (4) and a cluster of five infected persons at a squash facility
in Slovenia (5), few published reports are available regarding transmission associated with specific sports games or practices. In addition, outbreaks of COVID-19 infections among amateur hockey players in the United States have recently been reported in the
news.(†). |
|
Austin, Wes, Carattini, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie |
We examine the relationship between contemporaneous fine particulate matter exposure and COVID-19 morbidity and mortality
using an instrumental variable approach based on wind direction. Harnessing daily changes in county-level wind direction, we show that arguably exogenous fluctuations in local air quality impact the rate of confirmed cases and deaths from COVID-19. In our
preferred high dimensional fixed effects specification with state-level policy and social distancing controls, we find that a one μg/m3 increase in PM 2.5 increases the number of confirmed cases by roughly 2% from the mean case rate in a county. These effects
tend to increase in magnitude over longer time horizons, being twice as large over a 3-day period. Meanwhile, a one μg/m3 increase in PM 2.5 increases the same-day death rate by 3% from the mean. Our estimates are robust to a host of sensitivity tests. These
results suggest that air pollution plays an important role in mediating the severity of respiratory syndromes such as COVID-19, for which progressive respiratory failure is the primary cause of death, and that policy levers to improve air quality may lead
to improvements in COVID-19 outcomes. |
|
|
Aydillo, Teresa, Rombauts, et al |
medRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
We longitudinally profiled the early humoral immune response against SARS-CoV-2 on hospitalized COVID-19 patients,
and quantify levels of pre-existing immunity to OC43, HKU1 and 223E seasonal coronaviruses. A strong back-boosting effect to conserved, but not variable regions of OC43 and HKU1 betacoronaviruses spike protein was observed. All patients developed antibodies
against SARS-CoV-2 spike and nucleoprotein, with peak induction at day 7 post hospitalization. However a negative correlation was found between antibody memory boost to human coronaviruses and induction of IgG and IgM against SARS-CoV-2 spike. Our findings
provide evidence of immunological imprinting that determine the antibody profile to COVID-19 patients in an original antigenic sin fashion. |
|
|
Aydin, N, Yurdakul, et al |
Appl Soft Comput |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This study aims to contribute to the literature by performing detailed analyses via a new three-staged framework constructed
based on data envelopment analysis and machine learning algorithms to assess the performances of 142 countries against the COVID-19 outbreak. Particularly, clustering analyses were made using k-means and hierarchic clustering methods. Subsequently, efficiency
analysis of countries were performed by a novel model, the weighted stochastic imprecise data envelopment analysis. Finally, parameters were analyzed with decision tree and random forest algorithms. Results have been analyzed in detail, and the classification
of countries are determined by providing the most influential parameters. The analysis showed that the optimum number of clusters for 142 countries is three. In addition, while 20 countries out of 142 countries were fully effective, 36% of them were found
to be effective at a rate of 90%. Finally, it has been observed that the data such as GDP, smoking rates, and the rate of diabetes patients do not affect the effectiveness level of the countries. |
|
|
Azad, GK |
Biochem Biophys Rep |
Coronavirology| Coronavirologie |
In this study, we focused on identifying mutations in one of the crucial complex of SARS-CoV-2, the Nsp10-Nsp16 2'-O-methyltransferase
complex. This complex plays indispensable role in the post-transcriptional modifications of viral RNA by its capping. We analysed 208 sequences of Nsp10-Nsp16 reported from India and compared with first reported sequence from Wuhan, China. Our analysis revealed
a single mutation in Nsp10 and five mutations in Nsp16 protein. We also show that these mutations are leading to alteration in the secondary structure of Nsp10-Nsp16. Further, the protein modelling studies revealed that the mutation of both Nsp10-Nsp16 impacts
the protein dynamicity and stability. Altogether, this study provides novel insights into the variations observed in the proteins of SARS-CoV-2 that might have functional consequences. |
|
|
COVID-19 infection in kidney transplant recipients at the epicenter of pandemics |
Azzi, Y, Parides, et al |
Kidney Int |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated the prevalence and clinical outcomes of COVID-19 in recipients of kidney transplants in the Bronx,
New York, one of the epicenters of the pandemic. Between March 16 and June 2, 2020, 132 kidney transplant recipients tested positive by SARS-CoV-2 RT-PCR. From May 3 to July 29, 2020, 912 kidney transplant recipients were screened for SARS-CoV-2 IgG antibodies
during routine clinic visits, of which 16.6% tested positive. Fifty-five of the 152 patients had previously tested positive by RT-PCR, while the remaining 97 did not have significant symptoms and had not been previously tested by RT-PCR. The prevalence of
SARS-CoV-2 infection was 23.4% in the 975 patients tested by either RT-PCR or SARS-CoV-2 IgG. Older patients and patients with higher serum creatinine levels were more likely diagnosed by RT-PCR compared to SARS-CoV-2 IgG. Sixty-nine RT-PCR positive patients
were screened for SARS-CoV-2 IgG antibodies at a median of 44 days post-diagnosis (Inter Quartile Range 31-58) and 80% were positive. Overall mortality was 20.5% but significantly higher (37.8% ) in the patients who required hospitalization. Twenty-three percent
of the hospitalized patients required kidney replacement therapy and 6.3% lost their allografts. In multivariable analysis, older age, receipt of deceased-donor transplantation, lack of influenza vaccination in the previous year and higher serum interleukine-6
levels were associated with mortality. Thus, 42% of patients with a kidney transplant and with COVID-19 were diagnosed on antibody testing without significant clinical symptoms, 80% of patients with positive RT-PCR developed SARS-CoV-2 IgG and mortality was
high among patients requiring hospitalization. |
|
Badellino, H, Gobbo, et al |
Int J Soc Psychiatry |
Public Health response| Interventions de santé publique |
The object of this study is to determine the initial impact on mental health of Argentine population, by measuring
the prevalence of anxiety, depression, insomnia, and self-perceived stress and by determining the associated risk factors, and to analyze that impact in relation to the number of confirmed cases and deaths. A cross-sectional survey was conducted through a
digital questionnaire, which was completed by 1,985 respondents between March 29 and April 12. The 62.4% of the surveyed population reported signs of psychological distress. It was found that being a woman, being 18 to 27 years old, living with family members
or a partner, smoking, and having a poor sleep quality were the significant risk factors. Despite the low number of COVID-19 confirmed cases and deaths at that time, a strong impact on mental health indicators was revealed. |
|
|
Studying the Similarity of COVID-19 Sounds based on Correlation Analysis of MFCC |
Bader, Mohamed, Shahin, et al |
arXiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Healthcare
Response | Réponse des soins de santé |
This paper illustrates the importance of speech signal processing in the extraction of the Mel-Frequency Cepstral Coefficients
(MFCCs) of the COVID-19 and non-COVID-19 samples and find their relationship using Pearson correlation coefficients. The results show high similarity in MFCCs between different COVID-19 cough and breathing sounds, while MFCC of voice is more robust between
COVID-19 and non-COVID-19 samples. |
|
Bakin, Evgeny, Stanevich, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
This study tested and applied a principle of "patient-like-mine" decision support (machine learning algorithms) in
rapidly changing conditions of a pandemic. The deployed tool allowed doctors to quickly estimate the current conditions of their patients by means of studying the most similar previous cases stored in the local health information system. Extensive testing
of the system during the first wave of COVID-19 has shown that this approach helps not only to draw a conclusion about the optimal treatment tactics and to train medical staff in real-time but also to optimize patients’ individual testing plans. |
|
|
Balestrino, M, Coccia, et al |
Intern Emerg Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques Public Health response|
Interventions de santé publique Healthcare Response | Réponse des soins de santé |
This study analyzed statistically the number of transient ischemic attacks (TIA), ischemic strokes (IS) and hemorrhagic
strokes (HS) between March 8 and May 2, 2020, the peak of the COVID-19 epidemic in Italy, and compared them with the identical period of 2019. Also analyzed the concentration of small particulate matter (PM(10)) in 2019 and 2020, to see if it could account
for modified incidence of strokes or TIA. Found a large, significant drop in TIA (- 51%) during the pandemic compared to the same period of 2019. By contrast, the number of HS was identical, and IS showed a not significant - 24% decrease. PM(10) concentration,
already low in 2019, did not further decrease in 2020. Patients kept seeking hospital care when experiencing permanent neurological symptoms (stroke), but they tended not go to the hospital when their symptoms were transient (TIA). |
|
|
Barbosa, CS, Chaves, et al |
Emerg Radiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study evaluated chest computed tomography (CT) findings of laboratory-confirmed COVID-19 cases and correlated
it with clinical and laboratorial signs of severe disease and short-term outcome. Median age was 52 years (IQR 39-63) with male predominance (60.7%). Most of the patients that did not require hospitalization had parenchymal involvement of less than 25% on
CT (84.6%). Among hospitalized patients, interlobular septal thickening and extensive lung disease (> 50% of parenchyma) were significantly more frequent in ICU-admitted patients (P = 0.018 and P = 0.043, respectively). Interlobular septal thickening also
correlated with longer ICU stay (P = 0.018). Low oxygen saturation (SpO(2) ≤ 93%) was associated with septal thickening (P = 0.004), diffuse distribution (P = 0.016), and pleural effusion (P = 0.037) on CT. All patients with > 50% of parenchymal involvement
showed SpO(2) ≤ 93%. Elevated C-reactive protein (CRP) levels (> 5.0 mg/dL) correlated with consolidation (P = 0.002), septal thickening (P = 0.018), diffuse distribution (P = 0.020), and more extensive parenchymal involvement (P = 0.017). |
|
|
Reduced prevalence of SARS-CoV-2 infection in ABO blood group O |
Barnkob, MB, Pottegård, et al |
Blood Adv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study performed a retrospective cohort analysis of all Danish individuals tested for SARS-CoV-2 between 27 February
2020 and 30 July 2020, with a known ABO and RhD blood group, to determine the influence of common blood groups on virus susceptibility. Participants (29% of whom were male) included 473 654 individuals tested for SARS-CoV-2 using real-time polymerase chain
reaction (7422 positive and 466 232 negative) and 2 204 742 nontested individuals, accounting for
∼38% of the total Danish population. Hospitalization and
death from COVID-19, age, cardiovascular comorbidities, and job status were also collected for confirmed infected cases. ABO blood groups varied significantly between patients and the reference group, with only 38.41% (95% confidence interval CI], 37.30-39.50)
of the patients belonging to blood group O compared with 41.70% (95% CI, 41.60-41.80) in the controls, corresponding to a relative risk of 0.87 (95% CI, 0.83-0.91) for acquiring COVID-19. |
|
Diagnosing the novel SARS-CoV-2 by quantitative RT-PCR: variations and opportunities |
Barreto, HG, de Pádua Milagres, et al |
J Mol Med (Berl) |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Healthcare
Response | Réponse des soins de santé |
This study assessed PCR variations in the SARS-CoV-2 diagnosis taking into account public genome sequences and diagnosis
kits used by different countries. And analyzed 226 SARS-CoV-2 genome sequences from samples collected by March 22, 2020. This work utilized a phylogenetic approach that reveals the early evolution of the virus sequence as it spreads around the globe and informs
the design of RT-qPCR primers and probes. The quick expansion of testing capabilities of a country during a pandemic is largely impaired by the availability of adequately trained personnel on RNA isolation and PCR analysis, as well as the availability of hardware
(thermocyclers). And proposed that rapid capacity development can circumvent these bottlenecks by training medical and non-medical personnel with some laboratory experience, such as biology-related graduate students. |
|
Public Support for Social Safety-Net Policies for COVID-19 in the United States,
April 2020 |
Barry, CL, Han, et al |
Am J Public Health |
Economics | Économie |
This study examined public support for health insurance, income support, and unemployment policies during the initial
phase of disease transmission and economic distress following the COVID-19 outbreak and assessed varying public support based on beliefs about the role of government. Of US adults, 77% supported paid sick leave, and a majority also supported universal health
insurance, an increased minimum wage, and various unemployment support policies. Public support for an active government role in society to improve citizens' lives increased by 10 percentage points during this initial pandemic response relative to September
2019. Belief in a strong governmental role in society was associated with greater support for social safety-net policies. |
|
Bartoszek, A, Walkowiak, et al |
Int J Environ Res Public Health |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
A study involving 471 subjects (85.6% female) was conducted online to assess pandemic-related stress and anxiety.
Women had higher mean scores of depression, loneliness, and daily life fatigue and more often than males started exercising. Among people professionally active before the pandemic, there were more cases of increased alcohol consumption than among students.
No differences in alcohol consumption patterns were found between genders. People living alone had higher scores of loneliness and daily life fatigue compared to those living with someone. Respondents who started taking any new drugs during COVID-19 home confinement
had higher outcomes in all questionnaires. During home confinement, high scores of depression, insomnia, loneliness, and everyday fatigue were observed. |
|
|
Belghmaidi, S, Nassih, et al |
Am J Case Rep |
Clinical data| Données cliniques |
This report describes the case of a 24-year-old woman with confirmed COVID-19, which presented with acute onset of
diplopia and strabismus of the left eye that occurred 3 days after the start of general symptoms. The patient had no significant medical history. Based on detailed ophthalmic and neurological examination, acute painless incomplete palsy of the third cranial
nerve was suspected. Oculo-cerebral magnetic resonance angiography was unremarkable. Blood tests revealed mild normocytic regenerative anemia. According to the Moroccan recommendations, chloroquine and azithromycin were started. After what, a quick improvement
of exotropia and diplopia was observed, and complete recovery was obtained by the sixth day of treatment. |
|
|
Bennett, D, Franchi, et al |
Postgrad Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This report describes the detection of SARS-CoV-2 in the pleural fluid. A 61-year-old male kidney transplant patient
with a history of multiple biopsy-confirmed acute rejections and chronic allograft rejection was admitted to our COVID-19 Unit with dry cough, exertional dyspnea, oliguria and abdominal distension. Lung ultrasound imaging, chest X-ray and CT scan showed left
pleural effusion and atelectasis of the neighboring lung parenchyma. RT-PCR was positive for SARS-CoV-2 in the pleural fluid and cytology showed mesothelial cells with large and multiple nuclei, consistent with a cytopathic effect of the virus. |
|
|
Berdullas Saunders, S, Gesteira Santos, et al |
Rev Esp Salud Publica |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
This study evaluated the national helpline designed to provide early psychological intervention to those people affected
by COVID-19. This service attended more than 15,000 calls and carried out more than 11,000 interventions and 9,500 follow-ups with the general population, healthcare and other essential professionals and the patients and relatives of the sick or deceased.
Results show that the majority of calls (45.7%) came from the Autonomous Community of Madrid, that women significantly used this service in a higher proportion than men (73.5%) and that the commonest age range among users was 40-59. 75.9% of consultations
were related to psychological problems linked to anxiety and depressive symptoms. However, grief symptoms also stood out among the patients or relatives of the sick and deceased and, to a lesser extent, stress symptoms were prevalent in the group of professionals. |
|
|
Berta, P, Paruolo, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper proposes a forecast approach based on the Vector Error Correction model for the daily counts of hospitalized
patients with symptoms and of patients in ICU, using publicly available data on the current COVID-19 outbreak in Italy, Switzerland and Spain. The level of analysis is the local government managing the health care system response, which corresponds to regions
for Italy. The one-week-ahead forecasts are validated with out-of-sample data over successive weeks; they are found to provide timely and robust prediction of ICU capacity needs in Lombardy, the most-affected Italian region, starting from the sample of the
first 2 weeks of data. The same methodology is successfully validated on other Italian regions, Switzerland and Spain. The paper provides the open-source software code to produce the forecasts. |
|
|
Rapid COVID-19 Modeling Support for Regional Health Systems in England |
Betcheva, Lidia, Erhun, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins
de santé |
This paper describes the real-time participatory modeling work that has been undertaken to support the regional efforts
to tackle COVID-19 in the East of England by applying dynamic data-driven approaches using time series modeling, Bayesian estimation, and system dynamics modeling. |
|
Bhargava, S, McKeever, et al |
Int J Womens Dermatol |
Healthcare Response | Réponse des soins de santé |
This study assessed immediate and long-term effects of the pandemic on dermatology practice on a large scale, including
the clinical activity of participant, frequency and types of procedures used, and teledermatology (TD) use. The percentages of responders providing in-person consultations (46.6% vs 100% before), and hospital service (27% vs 52.8% before), and doing procedures
(25.6% vs 100% before) decreased while practicing TD increased three-fold (75.2% vs 26.1% before) during pandemic (P 1,000 COVID-19 cases in the country (OR, 3.80 95% CI, 2.33-6.21]). |
|
|
Bhatia, K, Columb, et al |
Anaesthesia |
Healthcare Response | Réponse des soins de santé |
This study explored whether general anaesthesia rates for caesarean section changed during the peak of the pandemic
across six maternity units in the north-west of England. A significant reduction (7.7 to 3.7%, p < 0.0001) in general anaesthetic rates, risk ratio (95%CI) 0.50 (0.39-0.93), was noted across hospitals during the pandemic. Regional to general anaesthesia conversion
rates reduced (1.7 to 0.8%, p = 0.012), risk ratio (95%CI) 0.50 (0.29-0.86). Obstetric indications for caesarean sections did not change (p = 0.17) whilst the overall caesarean section rate increased (28.3 to 29.7%), risk ratio (95%CI) 1.02 (1.00-1.04), p
= 0.052. |
|
|
Venous thromboembolism and COVID-19: a case report and review of the literature |
Bhatt, H, Singh, et al |
J Med Case Rep |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This report presents a case of 65-year-old Caucasian male patient presented to the emergency department with a 2-day
history of dyspnea, tested positive for COVID-19. The computed tomography angiogram of the chest showed significant moderately large, bilateral pulmonary emboli with a saddle embolus, and an associated small, left lower lobe, pulmonary infarct. Ultrasound
of the lower extremity showed non-occlusive deep vein thrombosis at the distal left femoral vein to the left popliteal vein |
|
Sex differences in self-report anxiety and sleep quality during COVID-19 stay-at-home
orders |
Bigalke, JA, Greenlund, et al |
Biol Sex Differ |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
This study assessed the impact of COVID-19 and stay-at-home orders on self-report anxiety and sleep quality, with a
focus on sex differences. Women (80.3%) reported higher prevalence of increased general anxiety due to COVID-19 when compared to men (50%; p = 0.001) and elevated STAI state anxiety compared to men (43 ± 1 vs. 38 ± 1 a.u., p = 0.007). Despite these differences
in anxiety, the perceived impact of COVID-19 on PSQI was not different between sexes. However, when stratified by perceived changes in anxiety due to COVID-19, participants with higher anxiety responses to COVID-19 had higher ISI compared to those with no
perceived changes in anxiety (9 ± 1 vs. 5 ± 1 a.u., p = 0.003). Additionally, participants who reported reduced sleep quality due to COVID-19 reported higher state anxiety (45 ± 1 a.u.) compared to those that perceived no change (36 ± 2 a.u., p = 0.002) or
increased (36 ± 2 a.u., p < 0.001) sleep quality. |
|
PMC7550277; How Covid-19 Pandemic Affected Shoulder and Elbow Practice in Turkey? |
Birsel, O, Eren, et al |
JSES Int |
Healthcare Response | Réponse des soins de santé |
This survey documented the preventive attitude and its variations against Covid19 pandemic in a specific group: Shoulder
and elbow surgeons; evaluated their perception of emergency and envisaged the 'new normal' with the altered order of priority in the upcoming post-coronavirus era. Eighty-eight responses collected from 129 members of TSSES (68%), with a mean 13.9 years of
practice in shoulder and elbow surgery. More than 75% decrease in surgical and outpatient clinical activity was documented. Half of respondents used telemedicine and the rate of obtaining informed consent remained low. The preventive attitude showed significant
variation. |
|
Nutrition Behaviors in Polish Adults before and during COVID-19 Lockdown |
Błaszczyk-Bębenek, E, Jagielski, et al |
Nutrients |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
This survey assessed the eating habits and self-reported anthropometric measurements, referring to "before" and "during"
lockdown. The majority (51.6%) of the respondents did not eat outside the house during lockdown (p < 0.0001). The number of meals eaten during the day during lockdown increased significantly, 11.2% of the respondents ate 5 and more meals (p < 0.0001). The
percentage of people snacking between meals increased by 5.1% during lockdown (p = 0.0001). Eggs, potatoes, sweets, canned meat and alcohol were consumed considerably more commonly during lockdown, while fast-food products, instant soups and energy drinks
were eaten or drunk significantly less frequently. A marked decrease in the number of daily servings of the following products was observed: bakery products, red meat, fast food, instant soups, sweet beverages and energy drinks. Conversely, the number of daily
servings of sweets and canned meat significantly increased. Two thirds of the respondents reported body weight changes, with 45.86% of the participants being overweight during lockdown. |
|
Boezaart, AP, Botha, et al |
Neuromodulation |
Clinical data| Données cliniques |
This clinical letter reports on two patients with stage 3 COVID‐19 in whom IL‐6 levels were markedly elevated and in
whom transcutaneous auricular Vagus Nerve Stimulation (taVNS) may have drastically reduced IL‐6 blood levels over a relatively short period of time. Both patients recovered in between 7-10 days after ythe ta VNS treatment. |
|
|
PMC7550866; Fenoterol and dobutamine as COVID-19 main protease inhibitors:
A virtual screening study |
Bolelli, K, Ertan-Bolelli, et al |
J Mol Struct |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study used structure based virtual screening method on FDA approved drugs and compounds in clinical trials. As
a result of this study we choose three most prominent compounds for further studies. And show that these three compounds (dobutamine and its two derivatives) can be considered as promising inhibitors for COVID-19 main protease and results also demonstrate
the possible interactions of dobutamine and its derivatives with COVID main protease (6W63) 6] |
|
Development of a prognostic model for mortality in COVID-19 infection using machine
learning |
Booth, AL, Abels, et al |
Mod Pathol |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This retrospective study evaluated the laboratory data and mortality from patients with positive RT-PCR assay results
for SARS-CoV-2 to identify prognostic serum biomarkers in patients at greatest risk of mortality. And developed a machine learning model using five serum chemistry laboratory parameters (c-reactive protein, blood urea nitrogen, serum calcium, serum albumin,
and lactic acid) from 398 patients (43 expired and 355 non-expired) for the prediction of death up to 48 h prior to patient expiration. The resulting support vector machine model achieved 91% sensitivity and 91% specificity (AUC 0.93) for predicting patient
expiration status on held-out testing data. |
|
Borgen, I, Romney, et al |
Popul Health Manag |
Healthcare Response | Réponse des soins de santé |
This study presents the intensive transitional care management (ITCM) intervention to optimize hospital bed capacity
through prevention of inpatient admissions for patients who could be discharged home safely with appropriate in-home medical support and tele-management. The primary outcome was the reduction in inpatient days as a result of the intervention that included
provision of at-home oxygen supplementation therapy, expanded home care services, and tele-management sessions. Secondary outcomes were re-encounters with the health system in the ED, observation unit, or inpatient readmissions. A total of 481.6 hospital patient
days were avoided for 78 patients who had been discharged from the ED or observation unit stays. |
|
|
Borrion, H, Kurland, et al |
PLoS One |
Public Health response| Interventions de santé publique |
This paper uses resilience as a lens through which to analyse disasters and other major threats to patterns of criminal
behaviour. The validity of the proposed resilience assessment tool is demonstrated using commercial theft data from the COVID-19 pandemic period. A 64 per cent reduction in crime was found in the studied city (China) during an 83-day period, before daily crime
levels bounced back to higher than expected values. |
|
|
Borro, L, Mazzei, et al |
Environ Res |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
This study modeled the role of Heating, Ventilation and Air Conditioning (HVAC) systems in the diffusion of the contagion
through Computational Fluid Dynamics (CFD) simulations of cough at the "Bambino Gesù" Vatican State Children's Hospital. The CFD-based simulations of the waiting room show that HVAC air-flow remarkably enhances infected droplets diffusion in the whole indoor
environment within 25 seconds from the cough event, despite the observed dilution of saliva particles containing the virus. At the same time also their number is reduced due to removal through the HVAC system or deposition on the surfaces. The proper use of
Local Exhaust Ventilation systems (LEV) simulated in the hospital room was associated to a complete reduction of infected droplets spreading from the patient's mouth in the first 0.5 seconds following the cough event. In the hospital room, the use of LEV system
completely reduced the η index computed for the patient hospitalized at the bed next to the spreader, with a decreased possibility of contagion. |
|
|
Bovet, M, Wadsack, et al |
Anaesthesist |
Clinical data| Données cliniques |
This case reports the exacerbation of COVID-19 following treatment with tocilizumab in a 59-year-old male patient
admitted to hospital diagnosed with moderate pneumonia associated with COVID-19. Upfront treatment with hydroxychloroquine and azithromycin was started. Due to a clinical deterioration (ARDS, circulatory shock) and greatly increased inflammation markers 6
days after admission, a cytokine storm was suspected and off-label treatment with the IL‑6 receptor antagonist tocilizumab was initiated. Subsequently there was a dramatic rise of D‑dimers indicating pulmonary intravascular coagulopathy and respiratory insufficiency
worsened. After a second dose of tocilizumab was administered severe perimyocarditis with cardiac arrhythmia, hemodynamic instability and ST elevation occurred. Shortly afterwards the patient died due to multiorgan failure. |
|
|
Countering misinformation via WhatsApp: Preliminary evidence from the COVID-19
pandemic in Zimbabwe |
Bowles, J, Larreguy, et al |
PLoS One |
Public Health response| Interventions de santé publique |
This paper examines how information from trusted social media sources can shape knowledge and behavior when misinformation
and mistrust are widespread. In a survey of 864 survey respondents, the authors found a 0.26σ increase in knowledge about COVID-19 as measured by responses to factual questions. Through a list experiment embedded in the survey, further found that potentially
harmful behavior-not abiding by lockdown guidelines-decreased by 30 percentage points. The results show that social media messaging from trusted sources may have substantively large effects not only on individuals' knowledge but also ultimately on related
behavior. |
|
Ocular Surface and Conjunctival Cytology Findings in Patients With Confirmed
COVID-19 |
Bozkurt, E, Özateş, et al |
Eye Contact Lens |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study assessed the effect of severe acute respiratory syndrome coronavirus-2 infection on the conjunctiva and
tear film. No significant difference was observed regarding the mean age and gender between the groups (P=0.786 and P=0.122, respectively). The mean TBUT and Schirmer II test results did not differ between the two groups (P=0.496 and P=0.447, respectively).
The CIC results revealed decreased density and cell size of goblet cells and moderate to high enlargement, squamous changes, and increased nucleocytoplasmic ratio in nongoblet epithelial cells in the COVID-19 group compared with the control group. Based on
the Nelson classification in CIC samples, 60.6% of the COVID-19 group and 19.4% of the control group had changes consistent with grade 2 or above. The presence of neutrophils in CIC was significantly higher in the COVID-19 group (P<0.001), whereas the presence
of lymphocyte was similar between the two groups (P=0.247). |
|
A Sensitive, Rapid, and Portable CasRx-based Diagnostic
Assay for SARS-CoV2 |
Brogan, DanielJ, Chaverra-Rodriguez, et al |
medRxiv |
Surveillance Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes
Healthcare Response | Réponse des soins de santé |
This paper outlines the development of a CRISPR-based nucleic acid molecular diagnostic utilizing a Cas13d ribonuclease
derived from Ruminococcus flavefaciens (CasRx) to detect SARS-CoV-2, an approach we term SENSR (Sensitive Enzymatic Nucleic-acid Sequence Reporter). And demonstrate SENSR robustly detects SARS-CoV-2 sequences in both synthetic and patient-derived samples by
lateral flow and fluorescence, thus expanding the available point-of-care diagnostics to combat current and future pandemics. |
|
High-Throughput Screening for Inhibitors of the SARS-CoV-2 Protease Using a FRET-Biosensor |
Brown, AS, Ackerley, et al |
Molecules |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This paper presents a biosensor for the 3-chymotrypsin-like cysteine protease from SARS-CoV-2, comprising a FRET-capable
pair of fluorescent proteins held in proximity by a protease cleavable linker. Demonstrate the utility of this biosensor for inhibitor discovery by screening 1280 compounds from the Library of Pharmaceutically Active Compounds collection. The screening identified
65 inhibitors, with the 20 most active exhibiting sub-micromolar inhibition of 3CL(pro) in follow-up EC(50) assays. The top hits included several compounds not previously identified as 3CL(pro) inhibitors, in particular five members of a family of aporphine
alkaloids that offer promise as new antiviral drug leads. |
|
SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS
patients |
Buetti, N, Wicky, et al |
Crit Care |
Epidemiology| Épidémiologie Clinical data| Données cliniques Coronavirology| Coronavirologie |
This study describes the viral shedding and the viral load in lower respiratory tract (LRT) and determines their association
with mortality in critically ill COVID-19 patients. The median time to negativity was 29 (IQR 23; 34) days. Prolonged viral shedding was not associated with age, gender, cardiac comorbidities, diabetes, immunosuppression, corticosteroids use, or antiviral
therapy. The LRT viral load tended to be higher in non-survivors. This difference was statistically significant after adjusting for the time interval between onset of symptoms and date of sampling (OR 3.78, 95% CI 1.13-12.64, p = 0.03). |
|
Buntinx, F, Claes, et al |
Acta Clin Belg |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes Immunology | Immunologie |
This study examined the added value of anti-SARS-CoV-2 antibody testing in a nursing home during an acute COVID-19
outbreak. 40 (34%) residents and 11 (13%) staff were PCR-positive. Using a rapid IgM/IgG test, 17 (17%) residents and 18 (20%) staff were positive for IgM and/or IgG (IgM/IgG). Thirty-two PCR-positive residents had an IgM/IgG test: 9 (28%), 11 (34%), and
13 (41%) were positive for IgM, IgG, and IgM/IgG. Ten PCR-positive staff had an IgM/IgG test: 3 (30%), 6 (60%), and 6 (60%) were positive for IgM, IgG, and IgM/IgG. Additional IgM/IgG tests were performed in 9 residents 11 to 14 days after the positive RT-PCR
test. Of those, 7 (78%) tested positive for IgM/IgG. When retested 3 weeks later, the 2 remaining residents also tested positive. Of the 134 PCR-negative participants who had an IgM/IgG test, 15 were positive for IgM/IgG (8% of the 200 participants tested
with RT-PCR). |
|
|
The social life of COVID-19: Early insights from social media monitoring data collected
in Poland |
Burzyńska, J, Bartosiewicz, et al |
Health Informatics J |
Public Health response| Interventions de santé publique |
This study reports the frequency, reach and impact of online mentions about the COVID-19 illness taken from social
media platforms: Facebook, Instagram, Twitter, blogs, forums, and news portals to highlight and better understand the scope of coronavirus discussion in Poland. Found a total of 1,415,750 mentions related to COVID-19 which gives the average 47,192 mentions
per day. 95.36% (1,350,059) of mentions were people's updates and expressions, 4.64% (65,691) mentions were articles from news portals and social media. Males have dominated the online conversation about COVID-19 (65.32% vs 34.68% females). At the same time,
women were more likely to discuss the topic on social media platforms such as: Facebook, Twitter, and Instagram. |
|
Buzhdygan, TP, DeOre, et al |
Neurobiol Dis |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
This report explored whether deleterious outcomes from the SARS-CoV-2 viral spike protein on primary human brain microvascular
endothelial cells (hBMVECs) could be observed. The spike protein, which plays a key role in receptor recognition, is formed by the S1 subunit containing a receptor binding domain (RBD) and the S2 subunit. The postmortem brain tissue showed that the angiotensin
converting enzyme 2 or ACE2 (a known binding target for the SARS-CoV-2 spike protein), is ubiquitously expressed throughout various vessel calibers in the frontal cortex. Moreover, ACE2 expression was upregulated in cases of hypertension and dementia. ACE2
was also detectable in primary hBMVECs maintained under cell culture conditions. Analysis of cell viability revealed that neither the S1, S2 or a truncated form of the S1 containing only the RBD had minimal effects on hBMVEC viability within a 48 h exposure
window. Introduction of spike proteins to in-vitro models of the blood-brain barrier (BBB) showed significant changes to barrier properties. Evidence provided suggests that the SARS-CoV-2 spike proteins trigger a pro-inflammatory response on brain endothelial
cells that may contribute to an altered state of BBB function. |
|
|
Cacho, PM, Hernández, et al |
Environ Health |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
This study assessed the influence of several climatic factors on the infectivity of SARS-CoV-2 and the severity of
COVID-19 among the Spanish Autonomous Communities (AA.CC.). From October 2019 to January 2020, mean UVR was significantly related not only to SARS-CoV-2 infection (cumulative incidence -previous 14 days- × 10(5) habitants, rho = - 0.0,666; p = 0.009), but
also with COVID-19 severity, assessed as hospital admissions (rho = - 0.626; p = 0.017) and ICU admissions (rho = - 0.565; p = 0.035). Besides, temperature (February: rho = - 0.832; p < 0.001 and March: rho = - 0.904; p < 0.001), was the main climatic factor
responsible for the infectivity of the coronavirus and directly contributed to a different spread of SARS-CoV-2 across the Spanish regions. |
|
|
Cai, Jiejie, Lu, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective study enrolled six patients who received Extracorporeal membrane oxygenation (ECMO) treatment and
recorded and analyzed the results of ventilator treatment following the adjustment of ventilator settings. During analysis, one patient died of COVID-19 within 28 days, and two patients were successfully weaned off mechanical ventilation and ECMO. Patients
with an improved condition have a longer time of spontaneous respiration and better static lung compliance (CLst) than those who worsen. With an instantaneous increase in oxygen concentration (FIO2) alone or a combination of Positive end-expiratory pressure
(PEEP) / FIO2, oxygen saturation (SpO2), and partial pressure of oxygen (PaO2) both increased, but no significant change was observed in PaCO2, PaO2/FIO2 and tidal volume (TV). With an instantaneous increase of PEEP alone, SpO2 , PaO2, PaCO2, PaO2/FIO2 and
TV showed no significant change. |
|
|
Cai, Y, Xu, et al |
Virol Sin |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This editorial report on the study that tested the in vitro inhibitory activity of griffithsin (GRFT) against infection
of pseudotyped and live SARS-CoV-2 infection, in order to repurpose the application of GRFT as a potential prophylactic or therapeutic to prevent or treat COVID-19. GRFT, a lectin isolated from the red alga Griffithsia sp, can recognize mannose with high affinity
and has a broad-spectrum antiviral activity. Results show that GRFT is highly effective in inhibiting the pseudotyped and live SARS-CoV-2 infection by binding to the glycosylation sites in the S1 subunit, possibly the RBD, of SARS-CoV-2 S protein, which is
in consistent with the mechanism by which GRFT inhibits SARS-CoV infection as noted in the literature. Notably, combining GRFT with the pan-CoV fusion inhibitor EK1 exhibited excellent synergistic effect against SARS-CoV-2 pseudovirus infection. Given that
GRFT can be easily manufactured in large quantities, it has a great potential to be further developed as a prophylactic or therapeutic, being used alone or in combination with EK1, in nasal spray or inhalation formulation to prevent or treat COVID-19, respectively. |
|
|
Canayaz, M |
Biomed Signal Process Control |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Healthcare
Response | Réponse des soins de santé |
This study proposed a deep learning-based approach that can be used for early diagnosis of the disease. In this approach,
a data set consisting of 3 classes of COVID19, normal and pneumonia lung X-ray images was created, with each class containing 364 images. Pre-processing was performed using the image contrast enhancement algorithm on the prepared data set and a new data set
was obtained. Feature extraction was completed from this data set with deep learning models such as AlexNet, VGG19, GoogleNet, and ResNet. For the selection of the best potential features, two metaheuristic algorithms of binary particle swarm optimization
and binary gray wolf optimization were used. After combining the features obtained in the feature selection of the enhancement data set, they were classified using SVM. The overall accuracy of the proposed approach was obtained as 99.38%. |
|
|
Candel, FJ, Barreiro, et al |
Rev Esp Quimioter |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Healthcare
Response | Réponse des soins de santé |
This document aims to support physicians involved in the care of patients with suspected SC2 infection, in the context
of a growing incidence in Spain since September 2020, which already represents the second pandemic wave of COVID-19. The main health institutions such as the WHO, the CDC and the Ministry of Health of the Government of Spain propose the use of antigenic tests
in a wide variety of strategies to respond to the pandemic. Antigenic tests have been shown to be more valid in the days around the onset of symptoms, when the viral load in the nasopharynx is higher. Having a rapid and real-time viral detection assay such
as the antigen test has been shown to be more useful to control the spread of the infection than more sensitive tests, but with greater cost and response time, such as in case of molecular tests. |
|
|
Cantu, L, Thomas, et al |
BMC Emerg Med |
Healthcare Response | Réponse des soins de santé |
This study explored community hospital emergency department staff's perceptions of critical incidents, assessed openness
to debriefing and measured baseline well-being. Thirty-nine clinical personnel from St. Vincent's Emergency Department responded to the survey. Events frequently selected as critical incidents were caring for critically ill children (89.7%), mass casualty
events (84.6%), and death of a patient (69.2%). Critical incidents were commonly reported (81.6%) as occurring once per week. Additionally, 76.2% of participants reported wanting to discuss a critical incident with their team. Across all respondents, 45.7%
scored borderline or abnormal for anxiety, 55.9% scored moderate for burnout, and 55.8% scored moderate to high for secondary traumatic stress. |
|
|
Cao, Y, Han, et al |
Sci Rep |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to assess the prognostic value of baseline clinical and high resolution CT (HRCT) findings
in patients with severe COVID-19. 101 patients were included in this study, of whom 66 were discharged and 35 died in the hospital. The mean age was 56.6 ± 15.1 years and 67 (66.3%) were men. Of the 101 patients, hypertension (38, 37.6%), cardiovascular disease
(21,20.8%), diabetes (18,17.8%), and chronic pulmonary disease (16,15.8%) were the most common coexisting conditions. The multivariable regression analysis showed older age (OR: 1.142, 95% CI 1.059-1.231, p < 0.001), acute respiratory distress syndrome (ARDS)
(OR: 10.142, 95% CI 1.611-63.853, p = 0.014), reduced lymphocyte count (OR: 0.004, 95% CI 0.001-0.306, p = 0.013), and elevated HRCT score (OR: 1.276, 95% CI 1.002-1.625, p = 0.049) to be independent predictors of mortality risk on admission in severe COVID-19
patients. |
|
|
Capurso, G, Archibugi, et al |
J Clin Gastroenterol |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
A survey was designed by the Lombardy section of Società Italiana di Endoscopia Digestiva (SIED) to analyze (a) changes
in activity and organization, (b) adherence to recommendations, (c) rate of health care professionals' (HCP) infection during the COVID-19 outbreak. In total, 35/61 invited centers (57.4%) participated; most modified activities were according to recommendations
and had filtering face piece 2/filtering face piece 3 and water-repellent gowns available, but few had negative-pressure rooms or provided telephonic follow-up; 15% of HCPs called in sick and 6% had confirmed COVID-19. There was a trend (P=0.07) toward different
confirmed COVID-19 rates among endoscopists (7.9%), nurses (6.6%), intermediate-care technicians (3.4%), and administrative personnel (2.2%). There was no correlation between the rate of sick HCPs and COVID-19 incidence in the provinces and personal protective
equipment availability and use, whereas an inverse correlation with hospital volume was found. |
|
|
Carissimo, G, Xu, et al |
Nat Commun |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we employ high dimensional flow cytometry to analyse a wide spectrum of more than 50 subsets of the
myeloid and lymphoid immune cell compartments. Comprehensive flow cytometry of whole blood samples from 54 COVID-19 patients reveals a dramatic increase in the number of immature neutrophils. This increase strongly correlates with disease severity and is associated
with elevated IL-6 and IP-10 levels, two key players in the cytokine storm. The most pronounced decrease in cell counts is observed for CD8 T-cells and VD2 γδ T-cells, which both exhibit increased differentiation and activation. ROC analysis reveals that the
count ratio of immature neutrophils to VD2 (or CD8) T-cells predicts pneumonia onset (0.9071) as well as hypoxia onset (0.8908) with high sensitivity and specificity. It would thus be a useful prognostic marker for preventive patient management and improved
healthcare resource management. |
|
|
Discriminating MIS-C Requiring Treatment from Common Febrile Conditions in Outpatient
Settings |
Carlin, RF, Fischer, et al |
J Pediatr |
Clinical data| Données cliniques |
This case-controlled study aimed to examine whether patients with multisystem inflammatory syndrome in children (MIS-C)
demonstrated well-defined clinical features distinct from other febrile outpatients given the difficulties of seeing acute care visits during the SARS-CoV-2 pandemic and the risks associated with both over and underdiagnosis of MIS-C. We identified 44 patients
with MIS-C between April 16 and June 10, 2020. During the same period 181 pediatric patients were evaluated for febrile illnesses in participating outpatient clinics. MIS-C patients reported higher median Tmax (40 degrees C vs 38.9, P < .0001), and increased
frequency of abdominal pain (OR 12.5, 95% CI 1.65-33.24]), neck pain (536.5, 2.23-129,029]), conjunctivitis (31.3, 4.6-212.8]), oral mucosal irritation (11.8, 1.4-99.4]), extremity swelling or rash (99.9, 5-1960]) and generalized rash (7.42, 1.6-33.2]). Patients
with MIS-C demonstrated lower absolute lymphocyte (p<0.0001) and platelet counts (p<0.05) and higher C-reactive protein concentrations (p<0.001). |
|
Carpinelli Mazzi, M, Iavarone, et al |
Eur Geriatr Med |
Public Health response| Interventions de santé publique |
The study evaluated the effects of the COVID-19 emergency lockdown on the psychological outcome in caregivers (children
or spouses) of patients with dementia and the loss of the welfare services in these patients. The sample consisted of 239 participants (men = 124; women = 115) with a mean age of 54.4 years (SD = 12.1). Education was associated with significantly lower overall
anxiety and depression scores while days of isolation and female gender were associated with the higher scores. A marked reduction of health services was observed in all patients. |
|
|
Carrasco-Sánchez, FJ, López-Carmona, et al |
Ann Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in
non-critically patients hospitalized with COVID-19. Of the 11,312 patients, only 2,128 (18.9%) had diabetes, and 2,289 (20.4%) died during hospitalization. The in-hospital mortality rates were 15.7% (180 mg/dl), p 180 mg/dl), p 180 mg/dl: HR 1.50; 95% CI:
1.31-1.73) (BG 140-180 mg/dl: HR 1.48; 95% CI: 1.29-1.70).Hyperglycemia was also associated with requirement for mechanical ventilation, ICU admission, and mortality. Admission hyperglycemiais a strong predictor of all-cause mortality in non-critically hospitalized
COVID-19 patients regardless ofprior history of diabetes. |
|
|
Carsi Kuhangana, T, Kamanda Mbayo, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
We conducted a cross-sectional study from 16 to 29 April 2020 among sellers and customers frequenting the food sections
of ten public markets in three large cities (Kolwezi, Likasi, and Lubumbashi) and one small town (Lwambo) of the former Katanga province. We administered a questionnaire on knowledge (about clinical characteristics, transmission and prevention) and on attitudes
in relation to COVID-19. Of the 347 included participants (83% women, 83% sellers), most had low socioeconomic status and a low level of education. Only 30% of participants had correct knowledge of COVID-19. The majority of the respondents (88%) showed no
confidence in the government's ability to manage the upcoming pandemic crisis. Nearly all respondents (98%) were concerned about the associated increase in food insecurity. Preventive practices were rarely in place. |
|
|
The Exposure Risk to COVID-19 in Most Affected Countries: A Vulnerability Assessment Model |
Cartaxo, Adriana Nascimento Santos, Barbosa, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie |
Health infrastructure and socioeconomic vulnerabilities may be affecting the response capacities of these countries.
We compared officials’ indicators to identify which vulnerabilities better determined the exposure risk to COVID-19 in both the most and least affected countries. The highest-risk group included the U.S., Brazil, and India, whereas the lowest-risk group (with
the largest population by continent) consisted of China, New Zealand, and Germany. The high-sensitivity cluster had 18 indicators (50% extra IDVI), such as merchandise trade, immunization, public services, maternal mortality, life expectancy at birth, hospital
beds, GINI index, adolescent fertility, governance, political stability, transparency/corruption, industry, and water supply. The greatest vulnerability of the highest-risk group was related first to economic factors (merchandise trade), followed by public
health (immunization), highlighting global dependence on Chinese trade, such as protective materials, equipment, and diagnostic tests. However, domestic political factors had more indicators, beginning with high sensitivity and followed by healthcare and economic
conditions, which signified a lesser capacity to guide, coordinate, and supply the population with protective measures, such as social distancing. |
|
Carvalho, FRS, Henriques, et al |
Photochem Photobiol |
Coronavirology| Coronavirologie |
The virucidal effectivity of ultraviolet radiation (UVR) depends on a first order on the sensitivity of the virus against
UVR as well as on the amount of incoming UVR. Here, we present estimates of the potential of solar UVR in inactivating SARS-CoV-2 in the environment. This is done by combining DNA-damaging surface solar UVR retrieved by satellites and the available information
on fluence for inactivation of Coronaviridae. Our results show that solar UVR has a high potential to inactivate these viruses, but the degree depends strongly on location and season. In the sub-tropics (Sao Paulo, 23.5°S) the daily survival fraction is lower
than 10(-4) during the whole year, while close at norther latitudes (Reykjavik, 64°N) such a reduction can be found in June and July only. |
|
|
Casali, N, Feraco, et al |
J Happiness Stud |
Public Health response| Interventions de santé publique |
This study focuses on the protective role of character strengths in sustaining mental health and self-efficacy during
lockdown. Data were collected from 944 Italian respondents (mean age = 37.24 years, SD = 14.50) by means of an online survey investigating character strengths, psychological distress and Covid-19-related self-efficacy one month after lockdown began. Regression
models with second-order factors showed that transcendence strengths had a strong inverse association with psychological distress, and a positive association with self-efficacy. Regression models with single strengths identified hope, zest, prudence, love
and forgiveness as the strengths most associated with distress, love and zest as the most related to self-efficacy and zest to general mental health. Openness factor and appreciation of beauty showed an unexpected direct relation with psychological distress. |
|
|
Castro Dopico, Xaquin, Hanke, et al |
medRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
We used robust IgM, IgG and IgA Ab tests to evaluate anti-SARS-CoV-2 responses in individuals PCR+ for virus RNA (n=105)
representing different categories of disease severity, including mild cases. All PCR+ individuals in the study became IgG-positive against pre-fusion trimers of the virus spike (S) glycoprotein, but titers varied greatly. Elevated IgA, IL-6 and neutralizing
responses were present in intensive care patients. Additionally, blood donors and pregnant women (n=2,900) sampled throughout the first wave of the pandemic in Stockholm, Sweden, further demonstrated that anti-S IgG titers differed several orders of magnitude
between individuals, with an increase of low titer values present in the population at later time points (4,5). To improve upon current methods to identify low titers and extend the utility of individual measures (6,7), we used our PCR+ individual data to
train machine learning algorithms to assign likelihood of past infection. Using these tools that assigned probability to individual responses against S and the receptor binding domain (RBD), we report SARS-CoV-2-specific IgG in 13.7% of healthy donors five
months after the peak of spring COVID-19 deaths, when mortality and ICU occupancy in the country due to the virus were at low levels. |
|
|
Cavaliere, AF, Marchi, et al |
J Med Virol |
Transmission Clinical data| Données cliniques |
We report a case of a neonate showing the presence of blood specific IgG and the absence of IgM and negative nasopharyngeal
swab. He was born from an asymptomatic SARS-CoV-2 infected mother with positive IgG and IgM. |
|
|
Cevasco, KE, North, et al |
PLoS One |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
An original database of COVID-19-related university NPI policy changes was compiled. Survey team members manually combed
university websites and official statements capturing implementation decisions and dates for five NPI variables from 575 U.S. universities, across 50 states and the District of Columbia, during March of 2020. The dataset enables event-time analysis and offers
a variety of variables to support institutional level study and identification of underlying biases like educational attainment. A descriptive analysis of the dataset reveals that there was substantial heterogeneity in the decisions that were made and the
timing of these decisions as they temporally related to key state, national, and global emergency announcements. The WHO pandemic declaration coincided with the largest number of university decisions to implement NPIs. |
|
|
Effectiveness of Penalties for Lockdown Violations During the COVID-19 Pandemic in
Germany |
Chae, SH, Park, et al |
Am J Public Health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study aimed to investigate whether the imposition of fines can mitigate the spread of COVID-19 by using a quasi-experimental
difference-in-difference model. On March 20, 2020, Bavaria introduced fines as high as €25 000 (US $28 186) against citizens in violation of the Bundesland's (federal state's) lockdown policy. Its neighboring Bundesländer (federal states), on the other hand,
were slow to impose such clear restrictions. By comparing 38 Landkreise (counties) alongside Bavaria's border from March 15 to May 11 using data from the Robert Koch Institute, we produced for each Landkreis its (1) time-dependent reproduction numbers (R(t))
and (2) growth rates in confirmed cases. Landkreise that introduced fines on March 20 reduced the R(t) by a further 0.32 (95% CI = -0.46, -0.18; P < .001) and decreased the growth rate in confirmed cases by an additional 6 percentage points (95% CI = -0.11,
-0.02; P = .005) compared with the control group. |
|
An engineered decoy receptor for SARS-CoV-2 broadly
binds protein S sequence variants |
Chan, KuiK, Tan, et al |
bioRxiv |
Coronavirology| Coronavirologie |
The spike S of SARS-CoV-2 recognizes ACE2 on the host cell membrane to initiate entry. Soluble decoy receptors, in
which the ACE2 ectodomain is engineered to block S with high affinity, potently neutralize infection and, due to close similarity with the natural receptor, hold out the promise of being broadly active against virus variants without opportunity for escape.
Here, we directly test this hypothesis. We find an engineered decoy receptor, sACE22.v2.4, tightly binds S of SARS-associated viruses from humans and bats, despite the ACE2-binding surface being a region of high diversity. Saturation mutagenesis of the receptor-binding
domain followed by in vitro selection, with wild type ACE2 and the engineered decoy competing for binding sites, failed to find S mutants that discriminate in favor of the wild type receptor. We conclude that resistance to engineered decoys will be rare and
that decoys may be active against future outbreaks of SARS-associated betacoronaviruses. |
|
Chatterjee, Bithika, Karandikar, et al |
medRxiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
In the first few months of its deadly spread across the world, Covid-19 mortality has exhibited a wide range of variability
across different nations. In order to explain this phenomenon empirically, we have taken into consideration all publicly available data for 106 countries on parameters like demography, prevalence of communicable and non-communicable diseases, BCG vaccination
status, sanitation parameters etc. We ran multivariate linear regression models to find that the incidence of communicable diseases correlated negatively while demography, improved hygiene and higher incidence of autoimmune disorders correlated positively
with Covid-19 mortality and were among the most plausible factors to explain Covid-19 mortality as compared to the GDP of the nations. |
|
|
COVID-19: Variant screening, an important step towards
precision epidemiology |
Chattopadhyay, Amrita, Lu, et al |
bioRxiv |
Clinical data| Données cliniques |
This study aspires to present a multi-omics view of how variations in the ACE2 and TMPRSS2 genes affect COVID-19 infection
and disease progression in affected individuals. It reports, for both genes, several variant and gene expression analysis findings, through (i) comparison analysis over single nucleotide polymorphisms (SNPs), that may account for the difference of COVID-19
manifestations among global sub-populations; (ii) calculating prevalence of structural variations (copy number variations (CNVs) / insertions), amongst populations; and (iii) studying expression patterns stratified by gender and age, over all human tissues.
This work is a good first step to be followed by additional studies and functional assays towards informed treatment decisions and improved control of the infection rate. |
|
Superspreading Event of SARS-CoV-2 Infection at a Bar, Ho Chi Minh City, Vietnam |
Chau, NVV, Hong, et al |
Emerg Infect Dis |
Epidemiology| Épidémiologie Transmission |
We report a superspreading event of severe acute respiratory syndrome coronavirus 2 infection initiated at a bar in
Vietnam with evidence of symptomatic and asymptomatic transmission, based on ministry of health reports, patient interviews, and whole-genome sequence analysis. Crowds in enclosed indoor settings with poor ventilation may be considered at high risk for transmission. |
|
Chen, F, Chen, et al |
Ann Hepatol |
Clinical data| Données cliniques |
The aims of our study were to investigate the changes of parameters (ALT, AST) in liver injury (LI) and determine the
risk factors for LI in a cohort of 830 COVID-19 patients. A total of 227 (27.3%) patients exhibited LBA and 32 (3.9%) patients were categorized as having LI based on the diagnostic criteria. 32.6% (74/227) of the LBA patients had RUCAM score >3, whereas the
non-LBA patients had a slight lower at rate of 24.2% (146/603) (P = 0.047). Multivariable regression showed that a higher incidence of LBA was associated with hepatic hypoattenuation on computed tomography (CT) (odds ratio: 2.243, 95% confidence interval:
1.410-3.592, p = 0.001), lymphocyte proportion 1 mg/dL (2.650, 1.845-3.806, p 1 (2.558, 1.820-3.596, p 1.0 mg/dL, lymphocyte proportion 1.0 mg/dL, lymphocyte proportion 1.7 mol/L are potential risk factors for LI. |
|
|
Secure Health Care Workers' Health and Safety Methodically During COVID-19 Epidemic
in Taiwan |
Chen, HC, Chen, et al |
Asia Pac J Public Health |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
The aim of this article is to assess the effectiveness of 3 measures of COVID-19 containment for securing health care
workers' (HCWs) safety and health at 5 medical university-affiliated hospitals in Taiwan. Three measures were to enforce the reporting of HCWs with unknown fever, acute respiratory illness, and other symptoms; to conduct ongoing surveillance to obtain early
warning of potential contagion exposure; and to perform epidemiological investigation and outbreak management. A 17-week surveillance data were collected, 374 (6.17%) HCWs with unknown fever or acute respiratory infection symptoms detected by online body temperature
surveillance system were reported, there were no cases of nosocomial infection of COVID-19 among HCWs. Via contact tracing and reporting system, 133 (2.19%) HCWs reported footprints in different epidemic events, but no HCWs were infected. No onward transmission
to HCWs occurred after containment measures were formulated. Integrated measures of surveillance, managing epidemic transmission chain, and encouraging individual responsibility have been effective approaches among HCWs in the ongoing COVID-19 epidemic. |
|
A Comparative Analysis of System Features Used in
the TREC-COVID Information Retrieval Challenge |
Chen, Jimmy, Hersh, et al |
medRxiv |
Public Health response| Interventions de santé publique |
The COVID-19 pandemic has resulted in a rapidly growing quantity of scientific publications from journal articles,
preprints, and other sources. The TREC-COVID Challenge was created to evaluate information retrieval methods and systems for this quickly expanding corpus. Based on the COVID-19 Open Research Dataset (CORD-19), several dozen research teams participated in
over 5 rounds of the TREC-COVID Challenge. We manually reviewed team run reports from Rounds 2 and 5, extracted features from the documented methodologies, and used a univariate and multivariate regression-based analysis to identify features associated with
higher retrieval performance. We observed that fine-tuning datasets with relevance judgments, MS-MARCO, and CORD-19 document vectors was associated with improved performance in Round 2 but not in Round 5. Though the relatively decreased heterogeneity of runs
in Round 5 may explain the lack of significance in that round, fine-tuning has been found to improve search performance in previous challenge evaluations by improving a system's ability to map relevant queries and phrases to documents. Furthermore, term expansion
was associated with improvement in system performance, and the use of the narrative field in the TREC-COVID topics was associated with decreased system performance in both rounds. These findings emphasize the need for clear queries in search. |
|
Chen, X, Huang, et al |
Zhongguo Zhen Jiu |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study aimed to establish and promote the non-contact doctor-patient interactive diagnosis and treatment mode based
on mobile internet for the treatment of COVID-19 with moxibustion therapy, and to observe the feasibility and effectiveness of the model in the pandemic. In 10 days of intervention with indirect moxibustion plaster, there was "zero" infection among medical
staff. Of 43 first-line physicians and nurses, 33 cases had some physical symptoms and psychological discomforts, mainly as low back pain, poor sleep and anxiety. After treatment, regarding the improvements in the symptoms and psychological discomforts, the
effective rate was 78.8% (26/33) and the curative rate was 36.4% (12/33). Regarding the improvements in psychological discomforts, the effective rate was 58.3% (14/24) and the curative rate was 37.5 (9/24). Of 149 patients, 133 cases had the symptoms and psychological
discomforts. After treatment, regarding the improvements in the symptoms and psychological discomforts, the effective rate was 81.2% (108/133) and the curative rate was 34.6% (46/133). Regarding the improvements in psychological discomforts, the effective
rate was 76.5% (52/68) and the curative rate was 57.4 % (39/68). |
|
|
Chen, X, Wu, et al |
Acta Pharm Sin B |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study aimed to determine human exposure to Lianhuaqingwen (LHQW) components and their anti-COVID-19 pharmacological
activities. Analysis of LHQW component profiles in human plasma and urine after repeated therapeutic dosing was conducted using a combination of HRMS and an untargeted data-mining approach, leading to detection of 132 LHQW prototype and metabolite components,
which were absorbed via the gastrointestinal tract and formed via biotransformation in human, respectively. Together with data from screening by comprehensive 2D angiotensin-converting enzyme 2 (ACE2) biochromatography, 8 components in LHQW that were exposed
to human and had potential ACE2 targeting ability were identified for further pharmacodynamic evaluation. Results show that rhein, forsythoside A, forsythoside I, neochlorogenic acid and its isomers exhibited high inhibitory effect on ACE2. For the first time,
this study provides chemical and biochemical evidence for exploring molecular mechanisms of therapeutic effects of LHQW capsule for the treatment of COVID-19 patients based on the components exposed to human. It also demonstrates the utility of the human exposure-based
approach to identify pharmaceutically active components in Chinese herb medicines. |
|
|
Outbreak minimization v.s. influence maximization: an optimization framework |
Cheng, CH, Kuo, et al |
BMC Med Inform Decis Mak |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
This study aims to develop an effective methodology for targeted immunization through the use of influence maximization.
We present a concise formulation of the targeted immunization problem and show its equivalence to the influence maximization problem under the framework of the Linear Threshold diffusion model. A comprehensive computational study is conducted to evaluate the
performance and scalability of the optimization approach on real-world large-scale networks. Computational results show that our proposed approaches achieve more effective solutions compared to existing methods. |
|
Cheng, Zhenguo, Zhang, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here we present a pivotal molecular mechanism of viral protein translation that relies on the mitochondrial translation
machinery. We found that rare codons such as Leu-TTA are highly enriched in many viruses, including SARS-CoV-2, and these codons are essential for the regulation of viral protein expression. SARS-CoV-2 controls the translation of its spike gene by hijacking
host mitochondria through 5' leader and 3'UTR sequences that contain mitochondrial localization signals and activate the EGR1 pathway. Mitochondrial-targeted drugs such as lonidamine and polydatin significantly repress rare codon-driven gene expression and
viral replication. This study identifies an unreported viral protein translation mechanism and opens up a novel avenue for developing antiviral drugs. |
|
|
Cherrak, SA, Merzouk, et al |
PLoS One |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The flavonoids chemical structures were downloaded from PubChem and protease structure 6LU7 was from the Protein Data
Bank site. Molecular docking study was performed using AutoDock Vina. Among the tested molecules Quercetin-3-O-rhamnoside showed the highest binding affinity (-9,7 kcal/mol). Docking studies showed that glycosylated flavonoids are good inhibitors for the SARS-CoV-2
protease and could be further investigated by in vitro and in vivo experiments for further validation. MD simulations were further performed to evaluate the dynamic behavior and stability of the protein in complex with the three best hits of docking experiments.
Our results indicate that the rutin is a potential drug to inhibit the function of Chymotrypsin-like protease (3CL pro) of Coronavirus. |
|
|
Chia, KX, Polakhare, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
Here we discuss the case of a previously fit and well 39-year-old man who presented with fever and respiratory symptoms,
evolving in pneumonia with hypoxia but only requiring continuous positive airway pressure. After resolution of the respiratory disease, the patient developed focal neurology and was found to have bilateral occipital, thalamic and cerebellar infarcts. A diagnosis
of COVID-19 central nervous system vasculopathy was made. He developed a florid neuropsychiatric syndrome, including paranoia, irritability, aggression and disinhibition, requiring treatment with antipsychotics and transfer to neurorehabilitation. Neuropsychometry
revealed a wide range of cognitive deficits. The rapid evolution of the illness was matched by fast resolution of the neuropsychiatric picture with mild residual cognitive impairment. |
|
|
Chinnadurai, R, Ogedengbe, et al |
BMC Geriatr |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We describe the clinical characteristics of all consecutive COVID-19 positive patients (n = 215) admitted to the acute
medical unit at Fairfield General Hospital (secondary care setting) between 23 March 2020 and 30 April 2020 based on the outcome at discharge (group 1: alive or group 2: deceased). The median age of our cohort was 74 years with a predominance of Caucasians
(87.4%) and males (62%). Of the 215 patients, 86 (40%) died. A higher proportion of patients who died were frail (group 2: 63 vs group 1: 37%, p < 0.001), with a higher prevalence of cardiovascular disease (group 2: 58 vs group 1: 33%, p < 0.001) and respiratory
diseases (group 2: 38 vs group 1: 25%, p = 0.03). In the multivariate logistic regression models, older age (odds ratio (OR) 1.03; p = 0.03), frailty (OR 5.1; p < 0.001) and lower estimated glomerular filtration rate (eGFR) on admission (OR 0.98; p = 0.01)
were significant predictors of inpatient mortality. KM curves showed a significantly shorter survival time in the frail older patients. |
|
|
Positive control synthesis method for COVID-19 diagnosis by one-step real-time RT-PCR |
Cho, H, Hwan Jung, et al |
Clin Chim Acta |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
A new approach for producing synthetic positive controls using synthetic positive template (SPT) oligonucleotides was
designed. SPT oligonucleotides contain probe binding and virus-irrelevant regions as templates for detecting SARS-CoV-2 genes (RdRP, E, and N SARS-CoV-2) by real-time RT-PCR was performed in a concentration-dependent manner. The limit of detection (LODs) with
SPT templates were >10(-15) (atto) M for RdRP, 10(-12) (femto) to 10(-13) (100 atto) M for E gene, and 10(-12) to 10(-14) (10 atto) M for N gene, respectively. Real-time RT-PCR assay using serially diluted genomic RNAs prepared from SARS-CoV-2 showed that
picogram quantities of RNAs prepared from COVID-19 virus cultures resulted in the LOD. The sensitivity based on Ct values for RdRP and E genes were less sensitive to this platform than N gene. This method significantly decreased the risk of contamination and
false-positive reactions that result from contamination of the synthesis procedures that are used to produce positive control materials. |
|
Cho, H, Li, et al |
Ethn Health |
Public Health response| Interventions de santé publique |
This study aimed to investigate factors associated with the stigmatization of people of Asian descent during COVID-19
in the United States and factors that can mitigate or prevent stigmatization. Racial prejudice, maladaptive coping, and biased media use each explained stigmatization. Racial prejudice, comprising stereotypical beliefs and emotion toward Asian Americans, was
a stronger predictor of stigmatization than maladaptive coping or biased media use. Fear concerning the ongoing COVID-19 situation and the use of social media and partisan cable TV also predicted stigmatization. Low self-efficacy in dealing with COVID-19,
when associated with high estimated harm of COVID-19, increased stigmatization. High perceived institutional efficacy in the handling of COVID-19 increased stigmatization when linked to high estimated harm of COVID-19. On the other hand, high perceived collective
efficacy in coping with COVID-19 was associated with low stigmatization. More indirect contacts with Asians via the media predicted less stigmatization. |
|
|
Waning Antibody Responses in Asymptomatic and Symptomatic SARS-CoV-2 Infection |
Choe, PG, Kang, et al |
Emerg Infect Dis |
Clinical data| Données cliniques Immunology | Immunologie |
We investigated the kinetics of severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in 7 asymptomatic
persons and 11 patients with pneumonia. The geometric mean titer of neutralizing antibodies declined from 219.4 at 2 months to 143.7 at 5 months after infection, indicating a waning antibody response. |
|
Choi, Y, Kim, et al |
Int J Environ Res Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This study aims at assessing the impact of social distancing on the reduction of COVID-19 infected cases by constructing
a mathematical model and using epidemiological data of incidences in Korea. We developed an age-structured mathematical model for describing the age-dependent dynamics of the spread of COVID-19 in Korea. We discovered that when the intensity of social distancing
is reduced, the number of COVID-19 cases increases; the number of incidences among the age groups of people 60 and above increases significantly more than that of the age groups below the age of 60. This significant increase among the elderly groups poses
a severe threat to public health because the incidence of severe cases and fatality rates of the elderly group are much higher than those of the younger groups. Therefore, it is necessary to maintain strict social distancing rules to reduce infected cases. |
|
|
Management of cardiovascular emergencies during the COVID-19 pandemic |
Choudhary, R, Gautam, et al |
Emerg Med J |
Healthcare Response | Réponse des soins de santé |
This was a retrospective study of patients presenting with cardiovascular emergencies to four tertiary regional emergency
departments in western India during the government implementation of complete lockdown. 25.0% of patients during the lockdown period and 17.4% of patients during the pre-lockdown period presented outside the window period (after 12 hours of symptom onset)
compared with only 6% during the pre-COVID period. In the pre-COVID period, 46.9% of patients with ST elevation myocardial infarction underwent emergent catheterisation, while in the pre-lockdown and lockdown periods, these values were 26.1% and 18.8%, respectively.
The proportion of patients treated with intravenous thrombolytic therapy increased from 18.4% in the pre-COVID period to 32.3% in the post-lockdown period. In hospital mortality for acute coronary syndrome (ACS) increased from 2.69% in the pre-COVID period
to 7.27% in the post-lockdown period. There was also a significant decline in emergency admissions for non-ACS conditions, such as acute decompensated heart failure and high degree or complete atrioventricular block. |
|
MALVIRUS: an integrated web application for viral variant
calling |
Ciccolella, Simone, Denti, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Being able to efficiently call variants from the increasing amount of sequencing data daily produced from multiple
viral strains is of the utmost importance, as demonstrated during the COVID-19 pandemic, in order to track the spread of the viral strains across the globe. We present MALVIRUS, an easy-to-install and easy-to-use web application that assists users in two tasks:
(1) computing a variant catalog consisting in a set of population SNP loci from the population sequences and (2) efficiently calling variants of the catalog from a read sample. Tests on Illumina and Nanopore samples prove the efficiency and the effectiveness
of MALVIRUS in genotyping SARS-CoV-2 strain samples with respect to GISAID data. |
|
Çiriş Yildiz, C, Ulaşli Kaban, et al |
Arch Environ Occup Health |
Healthcare Response | Réponse des soins de santé |
This study aimed to evaluate the comfort of personal protective equipment (PPE) used during the COVID-19 and attitudes
of healthcare professionals regarding the use of PPE. Descriptive research was conducted with 553 healthcare professionals, who work in a pandemic center in Turkey. Findings showed that all participants used masks, 99.3% wore gloves, 89% wore protective glasses,
and 89% wore aprons during the COVID-19. The most-reported physical complaints have been dryness, irritation, and wound on the hands. Age and gender, as well as PPE discomfort, has been determined to affect the use of PPE. It might be concluded that age and
sex, as well as the discomfort caused by PPE, affected the use of PPE and the attitudes of healthcare professionals. |
|
|
Cohen, A, Selles, et al |
Clin Orthop Relat Res |
Public Health response| Interventions de santé publique |
QUESTIONS/PURPOSES: (1) Is there a difference in quality of life between patients in the COVID-19 period group (March
23, 2020 to May 4, 2020) and patients in a reference period group (from the same period in 2018 or 2019)? (2) Is there a difference in pain, hand function, anxiety, depression, and illness perception between patients in the COVID-19 period group and patients
in the reference period group? METHODS: This study was part of a large cohort study with routine outcome measures of patients with hand and wrist conditions. To answer our research questions, we analyzed two samples because not all PROMs were sent to participants
at the same time points after treatment. Each sample consisted of two groups: a COVID-19 period group and a reference period group. RESULTS: We found no between-group differences in the EQ-5D index score (standardized mean difference 0.035; p = 0.98). Furthermore,
there were no between-group differences in PROM scores for hand function, anxiety, or depression. There were, however, a few small differences in subdomain items regarding pain and illness perception, but we believe in aggregate that these are unlikely to
make a clinically important difference in our main finding. CONCLUSIONS: The COVID-19 pandemic and its associated lockdown had no influence on QoL and had little influence on secondary outcomes in participants who were part of the Hand-Wrist Study Cohort. |
|
|
Cohen, B, Baar, et al |
BMC Anesthesiol |
Healthcare Response | Réponse des soins de santé |
This nationwide cross-sectional study evaluated the readiness and involvement of anesthesia departments in Israel in
management of the COVID-19 pandemic. The impact on anesthesiologists' health, workload, and clinical practices were also evaluated. METHODS: An online questionnaire was distributed to all of anesthesia department chairs in Israel on April 14th. Each response
was identifiable on the hospital level only. RESULTS: A decrease of at least 40% in operating-room activity was reported by two-thirds of the departments. Anesthesiologists are leading the treatment of COVID-19 patients in 19/28 hospitals. Israel Society
of Anesthesiologists' recommendations regarding intubation of COVID-19 patients were strictly followed. Anesthesiologists in most departments use standard personal protective equipment when caring for COVID-19 patients, including N95 masks, face shields, and
water-proof gowns. Only one anesthesiologist across Israel was diagnosed with COVID-19. |
|
|
Coleman, JR, Abdelsattar, et al |
J Am Coll Surg |
Healthcare Response | Réponse des soins de santé |
To better understand how the COVID-19 pandemic has affected surgical trainees' and early-career surgeons' professional
and personal experiences, a survey of the membership of the American College of Surgeons (ACS) Resident and Associate Society (RAS) and Young Fellows Association (YFA) was performed. STUDY DESIGN: An anonymous online survey was disseminated to members of RAS
and YFA. RESULTS: The majority (96%) of respondents reported the COVID-19 pandemic having a negative impact on their clinical experience, with 84% residents reporting >50% reduction in operative volume and inability to meet minimum case requirements. Respondents
also reported negative impacts on personal wellness |
|
|
Congenital SARS-CoV-2 Infection in a Neonate With Severe Acute Respiratory Syndrome |
Correia, CR, Marçal, et al |
Pediatr Infect Dis J |
Transmission Clinical data| Données cliniques |
We report a case of vertical transmission of SARS-CoV-2 in a preterm born to an infected mother. |
|
Cousin, N, Bourel, et al |
Asaio j |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to compare the outcomes, the clinical characteristics and the adverse effects of COVID-19 patients to a retrospective
cohort of influenza patients. This retrospective case-control study was conducted in the ICUs of Lille and Rouen University Hospitals between January 2014 and May 2020. Two independent cohorts of patients with ARDS requiring V-V ECMO infected with either COVID-19
(n =30) or influenza (n=22) were compared. The 28-day mortality rate did not significantly differ between COVID-19 (43.3%) and influenza patients. There was no significant difference considering the cumulative incidence of ECMO weaning, hospital discharge
and 3-month survival. COVID-19 patients had a lower SAPS II score, a higher Body Mass Index, and were cannulated later (median delay between mechanical support and V-V ECMO compared to influenza patients. No difference in overall adverse events was observed
between COVID-19 and influenza patients . |
|
|
Post-traumatic growth and influencing factors among frontline nurses fighting against
COVID-19 |
Cui, PP, Wang, et al |
Occup Environ Med |
Healthcare Response | Réponse des soins de santé |
OBJECTIVE: To explore the level and influencing factors of frontline nurses' post-traumatic growth (PTG) during COVID-19
epidemic. METHODS: A cross-sectional survey was conducted in February 2020 in three hospitals in China. The Post-traumatic Growth Inventory (PTGI) was used to investigate the PTG of frontline nurses. Data on related factors, including demographic characteristics
and subjective variables, were collected. RESULTS: The bivariate analyses showed that deliberate rumination was modestly positively correlated with PTG, while intrusive rumination had a modest negative correlation with PTG. Multiple linear regression demonstrated
that working years, self-confidence in frontline work, awareness of risk, psychological intervention or training during the epidemic and deliberate rumination were the main influencing factors of PTG among frontline nurses and accounted for 42.5% of the variance |
|
Shift in racial communities impacted by COVID-19 in California |
Cuomo, RE |
J Epidemiol Community Health |
Epidemiology| Épidémiologie |
Given documented racial disparities in other parts of the country, longitudinal convergence of COVID-19 rates around
race groups warrants assessment. METHODS: County-level cases for COVID-19 were collected from the Johns Hopkins University, and racial distributions were collected from the American Community Survey. Pearson's correlation coefficients were computed for each
day since COVID-19 was first reported in California, and the longitudinal distribution of each race-specific set of correlation coefficients was assessed for stationarity, linear trend and exponential trend. RESULTS: Earlier in the outbreak, the distribution
of COVID-19 was most highly correlated with Asian American communities; after approximately 100 days, the distribution of COVID-19 most closely resembled that of African American communities. For every day in this dataset, the county-level distribution of
COVID-19 was negatively correlated with the distribution of White American communities in California. |
|
Cvetković, D, Nešović, et al |
Energy Build |
Public Health response| Interventions de santé publique |
For a household located in Kragujevac (Central Serbia), 4 simulation scenarios were analyzed (S1 - reference case,
S2 - mild protection measures, S3 - semi-quarantine measures, S4 - complete quarantine) to assess the link between people's behavior (on the one hand) and the consumption of natural gas, electricity and water (on the other hand), in the residential sector,
in unforeseen circumstances, such as the COVID-19 virus pandemic. The analysis was conducted numerically for the month of March 2020. The simulatinos show that the consumption of natural gas can increase by 21.26% (S2), electricity by 58.39% (S4), and the
consumption of water from the city water supply network by 25.45% (S3) compared to the reference case (S1). On the other hand, based on the invoice for payment of services to distributors, the actual energy consumption that was made on the analyzed house during
the month of March 2020 was: natural gas (260.36 Sm(3)), electricity (1 418 kWh), and water (22.5 m(3)). |
|
|
Czeisler, MÉ, Garcia-Williams, et al |
MMWR Morb Mortal Wkly Rep |
Public Health response| Interventions de santé publique |
An Internet-based survey was conducted among U.S. adults aged ≥18 years during June 24-30, 2020. Overall, 85.2% of
respondents reported always or often engaging in hand hygiene following contact with high-touch public surfaces such as shopping carts, gas pumps, and automatic teller machines (ATMs). Respondents who were male (versus female) and of younger age reported lower
handwashing and hand sanitizing rates, as did respondents who reported lower concern about their own infection with SARS-CoV-2(§) and respondents without personal experience with COVID-19. |
|
|
PMC7546668; Bilateral macular hemorrhage in a patient with COVID-19 |
D'Aloisio, R, Nasillo, et al |
Am J Ophthalmol Case Rep |
Clinical data| Données cliniques |
Case of a patient with a known hereditary spherocytosis who developed a bilateral macular hemorrhage in concurrence
with COVID-19-related respiratory syndrome. |
|
Dietary Nicotianamine as a Factor in International
Variations of Mortality from Covid-19 |
Day, CharlesE |
medRxiv |
Epidemiology| Épidémiologie |
This report explores the inverse association of dietary nicotianamine intake with mortality from Covid-19 from numerous
countries. The data support a probable dramatic effect of nicotianamine in reducing coronavirus mortality. The best-case scenario of consuming a diet high in nicotianamine is a 100-fold reduction in Covid-19 mortality. Worst case is that one consumes a more
healthful diet that is less expensive and more environmentally friendly. |
|
de Farias, ECF, Pedro Piva, et al |
Pediatr Infect Dis J |
Clinical data| Données cliniques |
Case series of 11 children with pediatric multisystem inflammatory syndrome-temporally associated with SARS-CoV-2.
The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). The echocardiography findings were abnormal in 63% of cases. All patients had 2 or more organ dysfunctions,
and the mortality rate was 18%. |
|
|
Residual clinical damage after COVID-19: A retrospective and prospective observational
cohort study |
De Lorenzo, R, Conte, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aims of this study were to investigate whether COVID-19 leaves behind residual dysfunction, and identify patients
who might benefit from post-discharge monitoring. All patients aged ≥18 years admitted to the Emergency Department (ED) for COVID-19, and evaluated at post-discharge follow-up between 7 April and 7 May, 2020, were enrolled. Primary outcome was need of follow-up,
defined as the presence at follow-up of at least one among: respiratory rate (RR) >20 breaths/min, uncontrolled blood pressure (BP) requiring therapeutic change, moderate to very severe dyspnoea, malnutrition, or new-onset cognitive impairment, according to
validated scores. Post-traumatic stress disorder (PTSD) served as secondary outcome. 109 (58.9%) patients needed follow-up. At follow-up evaluation, 58 (31.3%) patients were dyspnoeic, 41 (22.2%) tachypnoeic, 10 (5.4%) malnourished, 106 (57.3%) at risk for
malnutrition. Forty (21.6%) patients had uncontrolled BP requiring therapeutic change, and 47 (25.4%) new-onset cognitive impairment. PTSD was observed in 41 (22.2%) patients. At regression tree analysis, the ratio of arterial oxygen partial pressure to fractional
inspired oxygen (PaO2/FiO2) and body mass index (BMI) at ED presentation, and age emerged as independent predictors of the need of follow-up. Patients with PaO2/FiO2 <324 and BMI ≥33 Kg/m2 had the highest odds to require follow-up. |
|
Dharawat, Arkin, Lourentzou, et al |
arXiv |
Public Health response| Interventions de santé publique |
To combat potential harm of COVID19-related misinformation, we release Covid-HeRA, a dataset for health risk assessment
of COVID-19-related social media posts. More specifically, we study the severity of each misinformation story, i.e., how harmful a message believed by the audience can be and what type of signals can be used to discover high malicious fake news and detect
refuted claims. We present a detailed analysis, evaluate several simple and advanced classification models, and conclude with our experimental analysis that presents open challenges and future directions. |
|
|
Myotonic dystrophy type 1 as a major risk factor for severe COVID-19? |
Dhont, S, Callens, et al |
Acta Neurol Belg |
Clinical data| Données cliniques |
People with myotonic dystrophy type 1 (DM1) represent a high-risk population during infectious disease outbreaks, little
is known about the potential impact of COVID-19 on patients with DM1. We studied the clinical course of COVID-19 in three hospitalized patients with myotonic dystrophy type 1 or Steinert's disease, between April 1, 2020-April 30-2020. Despite maximal supportive
care with oxygen therapy, antibiotics, intensive respiratory physiotherapy and non-invasive positive pressure ventilation, all three patients eventually died due to COVID-19. |
|
Di Mascio, D, D'Antonio, et al |
Eur J Obstet Gynecol Reprod Biol |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
Here we present a secondary analysis on perinatal mortality and morbidity in European compared with non-European pregnant
women involved in one of the largest retrospective cohort studies on COVID-19 during pregnancy. This was a multinational, retrospective cohort study that included all pregnant women with a laboratory-confirmed SARS-COV-2 infection, diagnosed between February
1, 2020 and April 30, 2020, in 72 centers from 22 different countries in Europe, Asia, North and South America and Australia. Neonates from mother positive to SARS-COV-2 were usually tested within 24 h after delivery with RT-PCR assay of nasal and pharyngeal
swab. The findings from this secondary analysis focused on regional differences shows that in European countries the rate of stillbirth was significantly lower, compared with non-European countries, while the rate of neonatal death was similar when evaluating
only pregnancies with live-born. In these subset of pregnancies, the rate of admission in neonatal intensive care unit (NICU) was significantly lower in European compared with non-European countries. Finally, there was no difference between European and non-European
countries in terms of intrauterine growth restriction, preterm birth before 37 weeks of gestation, possible vertical transmission and low birth weight |
|
|
Dia, N, Lakh, et al |
Emerg Infect Dis |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Senegal experienced its first COVID-19 suspected case on February 26. During February 26–March 4, a total of 26 suspected
case-patients (14 female and 12 male) were tested for a possible SARS-CoV-2 infection. Of the 26 suspected case-patients, 2 male and 2 female were confirmed as SARS-CoV-2 infected. We successfully obtained the complete genome sequences from the 4 SARS-CoV-2–positive
patients’ samples. The 4 complete genomes were nearly identical across the whole genome. Phylogenetic analyses revealed that SARS-CoV-2 strains from Senegal clustered with strains from diverse origins. The diagnosis of these cases showed the surveillance system
of Senegal’s capacity to quickly detect, isolate, and investigate those cases to take adequate control measures. Our findings indicate that the earliest cases in Senegal or sub-Saharan Africa were imported from Europe, implying that the particularly high volume
of direct flights from Europe was a key factor in the spread of the virus in West Africa. |
|
|
Septic Embolism in a Patient with Infective Endocarditis and COVID-19 |
Dias, CN, Brasil Gadelha Farias, et al |
Am J Trop Med Hyg |
Clinical data| Données cliniques |
36 year old case of COVID-19 with infective endocarditis |
|
PMC7546190; Implementation of a nurse practitioner led drive through COVID-19
testing site |
Dippel, KS, Kelly, et al |
J Nurse Pract |
Public health interventions*| Interventions de santé publique Healthcare Response |
Réponse des soins de santé |
Efficient strategies for testing large numbers of patients must be developed to limit the spread of COVID-19. We demonstrate
that our drive-through model is an efficient method of testing large numbers of patients during a pandemic. In the drive-through, cost per patient and PPE use were significantly less than three brick and mortar clinics providing testing. We provide an example
of effective nurse practitioner leadership in a drive-through testing site and demonstrate that NPs are ideally suited to provide leadership given their adaptability, ability to function in a variety of settings and extensive experience with care coordination
and logistics. |
|
Douglass, KM, Strobel, et al |
Am J Perinatol |
Clinical data| Données cliniques |
Two cases of acute respiratory distress syndrome (ARDS) secondary to novel coronavirus disease 2019 (COVID-19) in pregnant
women requiring extracorporeal membrane oxygenation (ECMO), and resulting in premature delivery. |
|
|
Swiss University Students' Risk Perception and General Anxiety during the COVID-19
Pandemic |
Dratva, J, Zysset, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
University students were confronted with abrupt changes to their daily lives by the COVID-19 lock-down. We investigated
Generalized Anxiety Disorder Scale-7 (GAD-7) and anxiety levels, and the association between perceived impact on well-being, studies, and daily lives and anxiety levels, adjusted for gender, age, social class and affiliation. Early in the lock-down all students
of the Zurich University of Applied Sciences (N = 12,429) were invited to a voluntary longitudinal health survey. A total of 10% reported a deterioration of well-being compared to pre-Corona. LCA yielded three classes varying in perceived COVID-19 impact:
1 (low, n = 675), 2 (moderate, n = 1098), and 3 (strong, n = 656). Adjusted proportion of moderate to severe anxiety by class were 45%, 15.5%, and 5.1%, respectively. |
|
COVID-19 Increases Online Searches for Emotional and Health-Related Terms |
Du, H, Yang, et al |
Appl Psychol Health Well Being |
Public Health response| Interventions de santé publique |
The current work investigated the emotional and behavioral reactions people experience in response to COVID-19 through
their internet searches. We hypothesised that when the prevalence rates of COVID-19 increase, people would experience more fear, which in turn would predict more searches for protective behaviors, health-related knowledge, and panic buying. METHODS: Prevalence
rates of COVID-19 in the United States, the United Kingdom, Canada, and Australia were used as predictors. Fear-related emotions, protective behaviors, seeking health-related knowledge, and panic buying were measured using internet search volumes in Google
Trends. RESULTS: We found that increased prevalence rates of COVID-19 were associated with more searches for protective behaviors, health knowledge, and panic buying. This pattern was consistent across four countries, the United States, the United Kingdom,
Canada, and Australia. Fear-related emotions explained the associations between COVID-19 and the content of their internet searches. |
|
Du, L, Cao, et al |
J Clin Lab Anal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to evaluate the values of routine fecal occult blood (FOB) test and urinary cytology test (UCT) for screening
of GI and UI in COVID-19 patients. METHODS: In this retrospective study, COVID-19 patients without associated comorbidities were divided into FOB- or UCT-positive or FOB- or UCT-negative groups. Their clinical characteristics and laboratory findings were then
compared. RESULTS: A total of 13.6% of patients (47 of 345) tested positive for FOB, and 57.4% (27 of 47) of these patients lacked gastrointestinal symptoms. A total of 30.1% of patients (104 of 345) exhibited gastrointestinal symptoms, and 38.0% (131 of 345)
were positive for either FOB or gastrointestinal symptoms. Fecal occult blood test in combination with gastrointestinal symptoms could serve as a simple and useful screening approach for GI diagnoses for COVID-19. Age and sex are risk factors for UI in COVID-19
patients. |
|
|
Dubey, AD |
JMIR Public Health Surveill |
Public Health response| Interventions de santé publique |
The aim of this paper is to analyze the increasing instances of cyber racism during the COVID-19 pandemic, by assessing
emotions and sentiments associated with tweets on Twitter. METHODS: In total, 16,000 tweets from April 11-16, 2020, were analyzed to determine their associated sentiments and emotions. his research analyzed the emotions and sentiments associated with terms
like "Chinese Virus," "Wuhan Virus," and "Chinese Corona Virus." RESULTS: The results suggest that the majority of the analyzed tweets were of negative sentiment and carried emotions of fear, sadness, anger, and disgust. There was a high usage of slurs and
profane words. In addition, terms like "China Lied People Died," "Wuhan Health Organization," "Kung Flu," "China Must Pay," and "CCP is Terrorist" were frequently used in these tweets. |
|
|
Duvignaud, A, Lhomme, et al |
Trials |
RCT |
RCT protocol to assess the efficacy of several repurposed drugs to prevent hospitalisation or death in patients aged
65 or more with recent symptomatic SARS-CoV-2 infection (COVID-19) and no criteria for hospitalisation. |
|
|
Eberly, AR, Challener, et al |
J Microbiol Immunol Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we assessed the potential correlation of initial PCR Cp values with duration of PCR positivity and disease
severity. Following an initial reverse transcription step, fluorescence output is monitored for a total of 45 cycles. Due to differences in target specificity, the detection of the NUC target (alone or in combination with ORF) is considered positive for SARS-CoV-2,
while detection of ORF alone is considered indeterminate. Seventy-three patients with two or more positive PCR tests had a median time of 23 days to two consecutive negative results. In this study cohort that included both outpatient and hospitalized individuals,
the PCR Cp value was not a strong predictor of the time to a negative result or current disease severity. |
|
|
Is there any association of COVID-19 with Testicular Pain and Epididymo-orchitis |
Ediz, C, Tavukcu, et al |
Int J Clin Pract |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aims to analyze the novel Coronavirus disease (COVID-19) related testicular pain in hospitalized patients
due to COVID-19 and to review as an etiological factor for epididymitis, orchitis or both. METHODS: A total of 91 patients were included in the study. A questionnaire was formed for the questioning of testicular pain or epididymo-orchitis in patients with
COVID-19. Patients with COVID-19 were divided into two groups according to absence or presence of testicular pain or epididymo-orchitis as group 1 and group 2. All results were compared for both groups. RESULTS: Testicular pain was occured in 10.98% of the
patients. Clinical presentation of epididymo-orchitis was diagnosed in only one patient. No statistically significant difference was reported in terms of patients' age, levels of CRP and D-Dimer or NLR and results of questionnaire form queries between the
two groups |
|
El Aferni, A, Guettari, et al |
Environ Sci Pollut Res Int |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In the present work, the sigmoidal-Boltzmann mathematical model was applied to study the Covid-19 spread in 15 different
countries. The cumulative number of infected persons I has been accurately fitted by the sigmoidal-Boltzmann equation (SBE), giving rise to different epidemiological parameters such as the pandemic peak t(p), the maximum number of infected persons I(max),
and the time of the epidemic stabilization t(∞). It is clear that the USA recorded the highest number of people infected with Covid-19 compared to other countries. However, it appears that the UK is the country least affected by the pandemic. By plotting
the variation in the cumulative number of infected persons with respect to time from the day of the first detected case, we noted a double sigmoidal growth for the 5 countries studied (Jordan, Lebanon, Malta, North Macedonia, and South Korea). |
|
|
Elayeh, E, Aleidi, et al |
PLoS One |
Public Health response| Interventions de santé publique |
Our research group initiated a study to ascertain the knowledge, attitude and practices (KAP) of Jordanians toward
COVID-19 prior to any initial case report in Jordan. This cross-sectional study randomly selected and recruited 2104 Jordanian adults. A four-section questionnaire was devised to address the sociodemographic characteristics of the subjects and their KAP toward
COVID-19. The mean knowledge score for the study population was 15.9 ± 2.2 (out of the 20 knowledge questions), with 60.9% of the participants having good knowledge about COVID-19. Participants' practices to prevent transmission of COVID-19 were adequate in
more than 60% of participants. Most participants had positive attitudes regarding their role in preventing COVID-19 and many of the participants' attitudes and practices changed to more appropriate ones after reporting the first case of COVID-19 in Jordan. |
|
|
2.5 Million Person-Years of Life Have Been Lost Due
to COVID-19 in the United States |
Elledge, StephenJ |
medRxiv |
Epidemiology| Épidémiologie |
To assess the impact of COVID-19 in the US, I have performed calculations of person-years of life lost as a result
of 194,000 premature deaths due to SARS-CoV-2 infection as of early October, 2020. By combining actuarial data on life expectancy and the distribution of COVID-19 associated deaths we estimate that over 2,500,000 person-years of life have been lost so far
in the pandemic in the US alone, averaging over 13.25 years per person with differences noted between males and females. Importantly, nearly half of the potential years of life lost occur in non-elderly populations. Issues impacting refinement of these models
and the additional morbidity caused by COVID-19 beyond lethality are discussed. |
|
Elmacioğlu, F, Emiroğlu, et al |
Public Health Nutr |
Public Health response| Interventions de santé publique |
The purpose of this study is to evaluate the possible effects of Corona Virus Disease-2019 (COVID-19) pandemic and
social isolation process on individuals' nutritional behaviors and body weight changes. DESIGN: Retrospective cohort study. SETTING: Nutritional behaviors of the participants before the COVID-19 pandemic and in the social isolation process were evaluated with
the Three Factor Nutrition Questionnaire (TFEQ-R18). The changes in individuals' body weight during this period was also evaluated. PARTICIPANTS: A total of 1036 volunteer individuals (827 women, 209 men) aged 18 and over participated in the study. RESULTS:
During the COVID-19 pandemic and social isolation process, there was an increase in emotional eating and uncontrolled eating behaviors of individuals, but no significant change in cognitive restriction behavior occurred. It was reported that the body weight
of 35% of the individuals who participated in the study increased during this period. |
|
|
Emodi-Perlman, A, Eli, et al |
J Clin Med |
Public Health response| Interventions de santé publique |
Univariate analyses (Chi(2)) were performed to investigate the effects of anxiety, depression, and personal concerns
of the Coronavirus pandemic, on the symptoms of TMD, and bruxism symptoms and their possible aggravation. RESULTS: The results showed that the Coronavirus pandemic has caused significant adverse effects on the psychoemotional status of both Israeli and Polish
populations, resulting in the intensification of their bruxism and TMD symptoms. |
|
|
Escalante-Maldonado, Oscar, Vidal-Anzardo, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Authors present the evaluation of a RT-LAMP for diagnosis of SARS-CoV-2 in two steps: the laboratory standardization
and the clinical validation, comparing it with the standard RT-qPCR. They conclude that this RT-LAMP protocol presented high diagnostic performance values and can be an effective alternative for COVID-19 molecular diagnosis in hospitals, contributing to early
diagnosis and reducing the spread of virus transmission in the Peruvian population. |
|
|
Rapid Systemwide Implementation of Outpatient Telehealth in Response to the COVID-19
Pandemic |
Esper, GJ, Sweeney, et al |
J Healthc Manag |
Healthcare Response | Réponse des soins de santé |
This paper discusses the COVID-19 pandemic, and its resultant social distancing, has disrupted the delivery of healthcare
for both patients and providers. Authors conclude that rapid deployment of virtual visits can be accomplished through a structured, organized approach including training, certification, and Lean principles. |
|
Estimating COVID-19 prevalence and infection control practices among US dentists |
Estrich, CG, Mikkelsen, et al |
J Am Dent Assoc |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
This paper focuses on COVID-19 transmission during oral health care delivery and assesses mitigation strategies for
dental offices which are critical to improving patient safety and access to oral health care. COVID-19 prevalence and testing positivity rates were low among practicing US dentists. |
|
Faes, L, Rosenblatt, et al |
Br J Ophthalmol |
Healthcare Response | Réponse des soins de santé |
The SARS-CoV-2 pandemic has imposed barriers to retinal care delivery worldwide, retinal services are exploring novel
ways to ensure access to healthcare. Digital health is taking the centre stage tackling unpreceded challenges of retinal care delivery during the SARS-CoV-2 pandemic and may sustainably change the way we practice ophthalmology. |
|
|
Fan, J, Yu, et al |
Clin Chim Acta |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
To clarify the effect of different respiratory sample types on SARS-CoV-2 detection, we collected throat swabs, nasal
swabs and hock-a-loogie saliva or sputum, and compared their detection rates and viral loads. The detection rates of sputum (95.65%, 22/23) and hock-a-loogie saliva (88.09%, 37/42) were significantly higher than those in throat swabs (41.54%, 27/65) and nasal
swabs (72.31%, 47/65) (P<0.001). The Ct Values of sputum, hock-a-loogie saliva and nasal swabs were significantly higher than that in throat swabs, whereas no significant difference was observed between sputum and saliva samples. Hock-a-loogie saliva are reliable
sample types that can be used to detect SARS-CoV-2, and worthy of clinical promotion. |
|
|
Impact of comorbidities on clinical prognosis in 1280 patients with different types
of COVID-19 |
Fang, H, Liu, et al |
J Investig Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The study aimed to compare the clinical characteristics and outcomes of patients with different types (ordinary, severe,
and critical) of COVID-19. Comorbidities prolonged treatment time in ordinary patients, increased the mortality rate and reduced the cure rate of critical patients; hypertension and diabetes may be important factors affecting the clinical course and prognosis
of ordinary and critical patients, respectively. |
|
PMC7544558; Analysis and Estimation of COVID-19 Spreading in Russia Based on ARIMA
Model |
Fang, L, Wang, et al |
SN Compr Clin Med |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Authors discuss the necessity of analyzing and predicting the COVID-19 epidemic situation to help formulate effective
public health policies in Russia. This paper indicates that Russia's health system capacity can effectively respond to the COVID-19 pandemic. |
|
Comparing antiviral strategies against COVID-19 via multi-scale within host modelling |
Fatehi, Farzad, Bingham, et al |
arXiv |
Therapeutics| Thérapeutique |
In this study, a stochastic agent-based model of COVID-19 intracellular dynamics is introduced here, that incorporates
essential steps of the viral life cycle targeted by treatment options. The model reveals that using both therapies in combination can be very effective in reducing the length of infection, but these synergistic effects decline with a delayed treatment start. |
|
Faust, L, Zimmer, et al |
Microbes Infect |
Healthcare Response | Réponse des soins de santé |
Authors aimed to investigate the availability and affordability of SARS-CoV-2 testing in the private health sector
in these settings. Given the large contribution of the private sector to healthcare provision in LMICs and the WHO recommendation of adopting a whole-of-society approach in responding to COVID-19, engaging the private sector in COVID-19 testing in LMICs is
critical to building up surge capacity. |
|
|
Feikin, DR, Widdowson, et al |
Pathogens |
Epidemiology| Épidémiologie |
Authors propose a relatively simple method for calculating the percentage of a population infected, which depends on
the number of reported Covid19 deaths, a figure usually more reliable and less dependent on variable testing practices than the total number of reported Covid19 cases, and the infection fatality rate, a figure that is relatively stable in similar populations.
This method is applicable to low- and lower-middle-income country (LMIC) settings where sero-survey data will likely be limited; however, better estimates of infection fatality rates and Covid19 death counts in LMICs are needed to improve the method's accuracy. |
|
|
Felsenstein, S, Willis, et al |
J Clin Med |
Clinical data| Données cliniques |
Authors report 29 patients with PIMS-TS who were diagnosed, admitted and treated in the English North West between
March and June 2020. Randomized and prospective studies are needed to investigate efficacy and safety of treatment, especially as resources of IVIG may be depleted secondary to high demand during future waves of COVID-19. |
|
|
Felson, Jacob, Adamczyk, et al |
medRxiv |
Public Health response| Interventions de santé publique |
This study uses mixed modeling techniques and data from 89% of two- and four-year public and four-year private US colleges
to assess the factors that shaped their decision to provide mostly in-person instruction as of August 1, 2020. The authors find that decision-making was unrelated to cumulative COVID infection and related mortality rates. |
|
|
Fernandes, DA, Yumioka, et al |
Rev Esp Enferm Dig |
Clinical data| Données cliniques |
We hereby report a case of COVID-19 who presented acute pancreatitis (AP) without any other risk factors, which emphasizes
the possibility of considering SARS-CoV-2 as a new etiological agent for AP. We suggest the study of pancreatic enzymes in COVID-19 patients with gastrointestinal symptoms, which may reveal pancreatic involvement that is not yet recognized in this population. |
|
|
Fiege, JessicaK, Thiede, et al |
bioRxiv |
Coronavirology| Coronavirologie |
The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-Sequencing
to understand how the heterogeneity of this diverse cell population contributes to elements of viral tropism and pathogenesis, antiviral immunity, and treatment response to remdesivir. We found that, while a variety of cell types are susceptible to infection,
ciliated cells are a predominant cell target for SARS-CoV-2. Remdesivir treatment effectively inhibited viral replication across cell types, and blunted hyperinflammatory responses. We also found that heavily infected epithelial cells demonstrate impaired
IFN signaling and express abundant IL-6, a potential mediator of COVID-19 pathogenesis.Competing Interest StatementThe authors have declared no competing interest. |
|
|
Fillmore, NR, Elbers, et al |
J Am Med Inform Assoc |
Healthcare Response | Réponse des soins de santé |
Authors discuss reducing risk of COVID-19 infection among healthcare personnel requires a robust occupational health
response involving multiple disciplines. They have developed an open-source application that facilitates communication and workflow across multiple disciplines to manage hospital employees impacted by the COVID-19 pandemic. |
|
|
Fleming, RichardM, Fleming, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques |
Currently there is no established treatment protocol for SARS-2 (CoVid-19). Proponents of hydroxychloroquine (HCQ)
argue that early intervention may sufficiently prevent replication of the virus and avoid the need for hospitalization. In instances where viral replication continues and the patient develops CoViD pneumonia (CVP), such patients – particularly with comorbidities
– are prone to develop an InflammoThrombotic response similar to cytokine release syndrome (CRS). We present one such patient who failed HCQ treatment and was subsequently treated successfully with an interleukin-6 inhibitor and interferon. |
|
|
Flood, SM, Osborne, et al |
Case Rep Pediatr |
Clinical data| Données cliniques |
The overwhelming majority of pediatric cases of SARS-CoV-2 infection are mild or asymptomatic with only a handful of
pediatric deaths reported. We present a case of severe COVID-19 infection in a pediatric patient with signs of hyperinflammation and consumptive coagulopathy requiring intubation and extracorporeal membrane oxygenation (ECMO) and eventual death due to ECMO
complications. |
|
|
Fragoso-Saavedra, S, Iruegas-Nunez, et al |
BMC Infect Dis |
RCT |
This clinical trial is aimed at evaluating if add-on of PDG leads to a decrease of invasive mechanical ventilation
and death among patients with severe COVID-19. This study will provide preliminary evidence of whether or not -by decreasing systemic inflammation- add-on PDG can improve clinical outcomes in patients with severe COVID-19. |
|
|
QTc prolongation among hydroxychloroquine sulfate-treated COVID-19 patients: An observational
study |
Fteiha, B, Karameh, et al |
Int J Clin Pract |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Authors evaluated the incidence of QTc prolongation among moderately and severely ill COVID‐19 patients treated with
hydroxychloroquine-sulphate (HCQ) and of the existence of concomitant alternative causes. In patients treated with HCQ, QTc prolongation was associated with the presence of traditional risk factors such as hypokalemia and furosemide treatment. |
|
Fung, A, Irvine, et al |
J Clin Transl Endocrinol |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to evaluate pediatric type 1 diabetes telehealth visits during the COVID-19 pandemic, with
a focus on assessing the usability of these visits and gathering patient perspectives. Telephone and virtual visits had impressive usability. Many families want telehealth to play a significant part in their future care. |
|
|
Gender differences in COVID-19 attitudes and behavior: Panel evidence from eight countries |
Galasso, V, Pons, et al |
Proc Natl Acad Sci U S A |
Public Health response| Interventions de santé publique |
Authors set out to assess the effectiveness of public health policies that hinge on generalized public obedience in
eight WHO countries. Gender differences in attitudes and behavior are sizable in all countries. They are accounted for neither by sociodemographic and employment characteristics nor by psychological and behavioral factors. |
|
Gambino, CM, Lo Sasso, et al |
Biochem Med (Zagreb) |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The aim of this study is to evaluate the agreement between the IgM/IgG rapid assays, based on lateral flow immunochromatographic
assay, and the fully automated 2019-nCoV IgM and IgG, based on chemiluminescence immunoassay. Results suggest that the immunochromatographic rapid IgM/IgG test and the chemiluminescence IgM and IgG immunoassay have a good degree of concordance, suggesting
that both could be considered as useful tools for epidemiologic surveillance. |
|
|
Proinflammatory cytokines are associated with prolonged viral RNA shedding in COVID-19
patients |
Gao, C, Zhu, et al |
Clin Immunol |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Since December 2019, Coronavirus Disease 2019 (COVID-19) has emerged as a global pandemic. We aimed to investigate
the clinical characteristics and analyzed the risk factors for prolonged viral RNA shedding. We retrospectively collected data from 112 hospitalized COVID-19 patients in a single center in Wuhan, China. Factors associated with prolonged viral RNA shedding
(≥28 days) were investigated. Forty-nine (43.8%) patients had prolonged viral RNA shedding. Patients with prolonged viral shedding were older and had a higher rate of hypertension. Proinflammatory cytokines, including interleukin-2R (IL-2R) and tumor necrosis
factor-α (TNF-α), were significantly elevated in patients with prolonged viral shedding. Multivariate analysis revealed that hypertension, older age, lymphopenia and elevated serum IL-2R were independent risk factors for prolonged viral shedding. This comprehensive
investigation revealed the distinct characteristics between patients with or without prolonged viral RNA shedding. Hypertension, older age, lymphopenia and high levels of proinflammatory cytokines may be correlated with prolonged viral shedding. |
|
COVID-19 neutralizing antibodies predict disease
severity and survival |
Garcia-Beltran, Wilfredo, Lam, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Authors examined antibody responses in 113 COVID-19 patients and found that severe cases resulting in intubation or
death exhibited increased inflammatory markers, lymphopenia, and high anti-RBD antibody levels. These results highlight the importance of neutralizing humoral immunity on disease progression and the need to develop broadly protective interventions to prevent
future coronavirus pandemics. |
|
Low dose radiation therapy for covid-19: effective dose and estimation of cancer
risk |
García-Hernández, T, Romero-Expósito, et al |
Radiother Oncol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The objective of this work is to evaluate the risk of carcinogenesis of low dose ionizing radiation therapy (LDRT),
for treatment of immune-related pneumonia following COVID-19 infection, through the estimation of effective dose and the lifetime attributable risk of cancer (LAR). The organs that mainly contribute to risk are lung and breast. Risk for out-of-field organs
is low, less than 0.06 cases per 10000. |
|
Gastaldelli, A, Mirco, et al |
J Am Coll Nutr |
Epidemiology| Épidémiologie |
Authors analyzed the COVID-19 Italian data during the first three months after the outbreak and the effect of lockdown.
Despite the lockdown, the number of infected and deceased patients in Italy was very high, with a lethality rate higher than in other countries. |
|
|
PMC7552946; Sources of information in times of health crisis: evidence from Turkey
during COVID-19 |
Geçer, E, Yıldırım, et al |
Z Gesundh Wiss |
Public Health response| Interventions de santé publique |
The purpose of this study was to determine the sources of information and investigate the role of various demographic
factors—age, gender, educational attainment and perceived economic level—on sources of information. This study provides evidence that a source of information might be influenced by demographic factors. |
|
Gerard, SarahE, Herrmann, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The purpose of this study was to develop a fully-automated segmentation algorithm, robust to various density enhancing
lung abnormalities, to facilitate rapid quantitative analysis of computed tomography images. The polymorphic training approach was able to accurately segment COVID-19 cases with diffuse consolidation without requiring COVID-19 cases for training. |
|
|
Effects of COVID-19 pandemic lockdown on gestational diabetes mellitus: A retrospective
study |
Ghesquière, L, Garabedian, et al |
Diabetes Metab |
Public Health response| Interventions de santé publique |
The objective of this study was to evaluate the impact of the lockdown period on the glycemic balance in patients with
GDM. Diabetes control was lower during the COVID-19 pandemic lockdown, even if follow-up was not impacted. This may be explained by reduced physical activity, modified dietary habits and anxiety during this period. |
|
PMC7550274; Report of four pregnant women getting COVID-19 in Ilam, Iran: Case
Series |
Gheysarzadeh, A, Sadeghifard, et al |
New Microbes New Infect |
Clinical data| Données cliniques |
This study aimed to report COVID-19 infection in four pregnant women in Ilam, Iran. This study showed although pregnant
women were at higher risk of COVID-19 infection, they were treated successfully. |
|
Ghorbani, A, Zare, et al |
New Microbes New Infect |
Vaccine Research| Recherche sur les vaccins |
This study aimed to predict immunogenic epitopes in silico by analyzed spike protein. Authors anticipate their assay
to be a starting point for guiding experimental efforts toward the development of a vaccine against SARS-CoV-2. |
|
|
Giampreti, A, Eleftheriou, et al |
J Perinat Med |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
The aim of this report is to describe the activity of Bergamo Teratology Information Service (TIS) in supporting the
public and health-care personnel in case of drug prescriptions in suspected/confirmed COVID-19 pregnant and lactating patients during COVID-19 outbreak in Italy. Tocilizumab may be considered for COVID-19 treatment because no increased malformation rate
were observed until now. |
|
|
COVID-19 in Italian Sjögren's syndrome patients: a monocentric study |
Giardina, F, Izzo, et al |
Rheumatol Int |
Epidemiology| Épidémiologie Clinical data| Données cliniques Public Health response|
Interventions de santé publique |
The authors examined data about contacts with subjects with COVID-19, COVID-19 incidence and related symptoms, current
therapy, comorbidities, other health problems and lockdown related impact on daily life. Patients were also asked about their adherence to the COVID-19 prevention measures proposed by the INIH and by the Italian Ministry of Health including frequent hands
washing, social distancing and the use of protective masks. |
|
Skin Manifestations in COVID-19: Prevalence and Relationship with Disease Severity |
Giavedoni, P, Podlipnik, et al |
J Clin Med |
Clinical data| Données cliniques |
Authors performed a retrospective analysis of a prospectively collected cohort of patients with SARS-CoV-2 infection
in a teaching hospital in Barcelona. Cutaneous lesions in patients with COVID-19 appear to be relatively rare and varied. Patients with chilblain-like lesions have a characteristic clinicopathological pattern and a less severe presentation of COVID-19. |
|
Refusals after prehospital administration of naloxone during the COVID-19 pandemic |
Glenn, MJ, Rice, et al |
Prehosp Emerg Care |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to determine if COVID-19 was associated with a change in patient refusals after Emergency
Medical Services (EMS) administration of naloxone. In this single EMS system, more than a two-fold increase in the rate of refusal after non-fatal opioid overdose was observed following the COVID-19 outbreak. |
|
Goenka, A, Ma, et al |
Adv Radiat Oncol |
Healthcare Response | Réponse des soins de santé |
In this manuscript, authors review implementation and report data on patient access to telehealth care and billing
implications. Since the onset of COVID-19 pandemic, the majority of patient visits were moved to telehealth but observed inconsistent utilization of the audio-video telehealth platform. |
|
|
Caregiver willingness to vaccinate their children against COVID-19: Cross sectional
survey |
Goldman, RD, Yan, et al |
Vaccine |
Public Health response| Interventions de santé publique |
The objective of this study was to investigate predictors associated with global caregivers' intent to vaccinate their
children against COVID-19, when the vaccine becomes available. 65% (n = 1005) of caregivers reported that they intend to vaccinate their child against COVID-19, once a vaccine is available. A univariate and subsequent multivariate analysis found that increased
intended uptake was associated with children that were older, children with no chronic illness, when fathers completed the survey, children up-to-date on their vaccination schedule, recent history of vaccination against influenza, and caregivers concerned
their child had COVID-19 at the time of survey completion in the ED. The most common reason reported by caregivers intending to vaccinate was to protect their child (62%), and the most common reason reported by caregivers refusing vaccination was the vaccine's
novelty (52%). |
|
High prevalence of cryofibrinogenemia in patients with chilblains during the COVID-19 outbreak |
Gómez-Fernández, C, López-Sundh, et al |
Int J Dermatol |
Clinical data| Données cliniques |
The aim of this study was to describe the clinical, pathological, and laboratory findings of a series of patients who
developed chilblains during the COVID‐19 outbreak and to investigate the possible factors that could be involved in the pathogenesis of these lesions. This study shows, for the first time a high prevalence of cryofibrinogenemia in patients with chilblains
during the COVID-19 pandemic. |
|
Goodsall, TM, Han, et al |
J Gastroenterol Hepatol |
Public Health response| Interventions de santé publique |
We aimed to prospectively evaluate the attitudes, concerns, and health behaviour of IBD patients during COVID-19. Of
97 respondents (39%), 95 (98%) reported concern about the impact of COVID-19 on their health and 43% felt their risk of contracting COVID-19 was above average. 62% reported concern about medication induced COVID-19 risk and 11% stopped medications because
of COVID-19. Patients considered all medications to increase risk of COVID-19 susceptibility and severity. 45% preferred telehealth whilst 16% preferred face-to-face clinic reviews. Preference for IBD monitoring tools in decreasing order was blood testing,
stool collection, gastrointestinal ultrasound, magnetic resonance enterography then colonoscopy. |
|
|
Comparative host-coronavirus protein interaction networks reveal pan-viral disease
mechanisms |
Gordon, DE, Hiatt, et al |
Science |
Coronavirology| Coronavirologie |
Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analysis
for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 Orf9b, an interaction
we structurally characterized using cryo-EM. Combining genetically-validated host factors with both COVID-19 patient genetic data and medical billing records identified important molecular mechanisms and potential drug treatments that merit further molecular
and clinical study. |
|
Characteristics and Prognosis of COVID-19 in Patients with COPD |
Graziani, D, Soriano, et al |
J Clin Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to explore the impact of COVID-19 in a large population-based sample of patients with COPD in Castilla-La
Mancha, Spain. Out of 31,633 COPD patients, 793 had a diagnosis of COVID-19. The proportion of patients with COVID-19 in the COPD population (2.51%; 95% CI 2.33-2.68) was significantly higher than in the general population aged >40 years (1.16%; 95% CI 1.14-1.18);
p < 0.001. Compared with COPD-free individuals, COPD patients with COVID-19 showed significantly poorer disease prognosis, as evaluated by hospitalizations (31.1% vs. 39.8%: OR 1.57; 95% CI 1.14-1.18) and mortality (3.4% vs. 9.3%: OR 2.93; 95% CI 2.27-3.79).
Patients with COPD and COVID-19 were significantly older (75 vs. 66 years), predominantly male (83% vs. 17%), smoked more frequently, and had more comorbidities than their non-COPD counterparts. Pneumonia was the most common diagnosis among COPD patients hospitalized
due to COVID-19 (59%); 19% of patients showed pulmonary infiltrates suggestive of pneumonia and heart failure. Mortality in COPD patients with COVID-19 was associated with older age and prevalence of heart failure (p < 0.05). |
|
Guillon, M, Kergall, et al |
Public health |
Public Health response| Interventions de santé publique |
We aim to identify the factors associated with support and compliance with general quarantine and with the acceptability
and potential use of a contact-tracing mobile phone application among French respondents. After reweighting, full data for regression analyses were available for 1849 respondents. Attitudes and opinions regarding quarantine are correlated with the perceived
COVID-19 threat, the perceived benefits of quarantine, trust in the government, well-being during quarantine and risk preferences. Trust in the government, perceived individual health consequences in case of COVID-19 infection and time preferences are associated
with the willingness to use a contact-tracing application. |
|
|
Guimond, ScottE, Mycroft-West, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here we show that heparan sulfate (HS) pixatimod (a synthetic drug candidate for cancer, with immunomodulatory and
heparanase-inhibiting properties) binds directly to the SARS-CoV-2 spike protein receptor binding domain (S1-RBD), altering its conformation and destabilizing its structure. Demonstration of potent anti-SARS-CoV-2 activity establishes that synthetic heparan
sulfate mimetics can target the HS-Spike protein-ACE2 axis. Together with other known activities of pixatimod our data provides a strong rationale for its further investigation as a potential multimodal therapeutic to address the COVID-19 pandemic. |
|
|
Gujski, M, Jankowski, et al |
J Clin Med |
Epidemiology| Épidémiologie Immunology | Immunologie |
We aimed to determine the prevalence of current and past SARS-CoV-2 infections among police employees. This cross-sectional
survey was undertaken among 5082 police employees from Mazowieckie Province, Poland. All RT-PCR tests were negative. The anti-SARS-CoV-2 IgM+IgA index was positive (>8) in 8.9% of participants, including 11.2% women and 7.7% men (p 6) in 4.3% and equivocal
(4-6) in 13.2% of participants. A higher odds of positive IgM+IgA index was found in women vs. men ( |
|
|
Guler, E, Unal, et al |
Abdom Radiol (NY) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This Turkish study aimed to correlate the liver-to-spleen ratio (L/S), clinical, laboratory findings, and lung CT scores
of patients with COVID-19 who had two consecutive chest CTs. Findings reveal that a decrease in L/S may be observed in patients with elevated lung CT scores at follow-up. WBC, neutrophil, lymphocyte, monocyte, and platelet counts at hospital admission may
predict the progression of COVID-19. |
|
|
AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19 |
Gupta, S, Coca, et al |
J Am Soc Nephrol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We conducted a multicenter cohort study of 3099 critically ill adults with COVID-19 admitted to intensive care units
(ICUs) at 67 hospitals across the United States. A total of 637 of 3099 patients (20.6%) developed AKI-RRT within 14 days of ICU admission, 350 of whom (54.9%) died within 28 days of ICU admission. Patient-level risk factors for AKI-RRT included CKD, men,
non-White race, hypertension, diabetes mellitus, higher body mass index, higher d-dimer, and greater severity of hypoxemia on ICU admission. Predictors of 28-day mortality in patients with AKI-RRT were older age, severe oliguria, and admission to a hospital
with fewer ICU beds or one with greater regional density of COVID-19. At the end of a median follow-up of 17 days (range, 1-123 days), 403 of the 637 patients (63.3%) with AKI-RRT had died, 216 (33.9%) were discharged, and 18 (2.8%) remained hospitalized.
Of the 216 patients discharged, 73 (33.8%) remained RRT dependent at discharge, and 39 (18.1%) remained RRT dependent 60 days after ICU admission. |
|
Halabi, Najeeb, Chamseddine, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
We mapped the impact of mitigation measures across different countries. We compared regional SARS-COV-2 population
burden via Kruskal-Wallis statistical testing. We analyzed time of adoption of mitigation measures and the impact of PCR testing on mitigation impact. We analyzed the association of climate, health, demographic and economic indicators with mitigation impact
via non-parametric correlation tests. We performed mechanistic modelling to predict short-term SARS-COV-2 case numbers in selected countries. we identified a geographic cluster of countries centered on the Arabian Peninsula (AP) that show a high SARS-COV-2
population burden despite early adoption of mitigation measures. We find that higher air pollution levels, higher CO2 emissions, and younger population were associated with reduced mitigation impact in AP countries. We also show that mechanistic modelling
can closely predict confirmed case numbers in the short term. |
|
|
Hammoud, MA, Maher, et al |
J Acquir Immune Defic Syndr |
Public Health response| Interventions de santé publique |
We investigated the impact of physical distancing measures due to COVID-19 on the sexual behavior of gay and bisexual
men in Australia. The mean age of was 39.9 years (SD: 13.4). Most participants (88.3%) reported sex with other men during the 6 months before COVID-19. Of the 587 men (62.4%) who reported sex with casual partners before COVID-19, 93 (15.8%) continued to do
so in the period since COVID-19, representing a relative reduction of 84.2%. |
|
|
ArCOV19-Rumors: Arabic COVID-19 Twitter Dataset for Misinformation Detection |
Haouari, Fatima, Hasanain, et al |
arXiv |
Public Health response| Interventions de santé publique |
In this paper we introduce ArCOV19-Rumors, an Arabic COVID-19 Twitter dataset for misinformation detection composed
of tweets containing claims from 27th January till the end of April 2020. We collected 138 verified claims, mostly from popular fact-checking websites, and identified 9.4K relevant tweets to those claims. We then manually-annotated the tweets by veracity to
support research on misinformation detection, which is one of the major problems faced during a pandemic. We aim to support two classes of misinformation detection problems over Twitter: verifying free-text claims (called claim-level verification) and verifying
claims expressed in tweets (called tweet-level verification). Our dataset covers, in addition to health, claims related to other topical categories that were influenced by COVID-19, namely, social, politics, sports, entertainment, and religious. |
|
Harris, BHL, Zuhair, et al |
J Infect Dis |
Clinical data| Données cliniques |
At the start of the UK COVID-19 epidemic, this rare point prevalence study reveals ⅓ of patients in a London inpatient
rehabilitation unit were found to be infected with SARS-CoV-2, but asymptomatic (n=15/45). We report on eight patients in detail, including their clinical stability, the evolution of their nasopharyngeal viral RT-PCR burden and their antibody levels over time
revealing the infection dynamics by RT-PCR and serology during the acute phase. Notably, a novel serological test for antibodies against the receptor binding domain of SARS-CoV-2 (anti-RBD) showed 100% of our asymptomatic cohort remained seropositive between
3 to 6 weeks post-diagnosis. |
|
|
Hashmi, P, Fahad, et al |
Ann Med Surg (Lond) |
Healthcare Response | Réponse des soins de santé Economics | Économie |
A single center retrospective study was conducted to quantify losses due to postponement of elective surgeries and
extra cost for procurement of PPEs. The secondary objective was to see the effect of Covid -19 on the total costs of inpatient care during Covid era. A total 625 patients were admitted during study period; 417 in precovid and 208 in covid era. The financial
income of our service decreased more than 55% due to postponement of elective work. The number of elective and procedures related to musculoskeletal trauma also decreased. The cost for inpatient care did not increase during covid era. There was significant
reduction in inpatient hospital stay during covid era. The hospital management had to spent additional expenses on procurement of PPEs. |
|
|
Low dispersion in the infectiousness of COVID-19 cases implies difficulty in control |
He, D, Zhao, et al |
BMC Public Health |
Epidemiology| Épidémiologie |
The individual infectiousness of coronavirus disease 2019 (COVID-19), quantified by the number of secondary cases of
a typical index case, is conventionally modelled by a negative-binomial (NB) distribution. Based on patient data of 9120 confirmed cases in China, we calculated the variation of the individual infectiousness, i.e., the dispersion parameter k of the NB distribution,
at 0.70 (95% confidence interval: 0.59, 0.98). This suggests that the dispersion in the individual infectiousness is probably low, thus COVID-19 infection is relatively easy to sustain in the population and more challenging to control. Instead of focusing
on the much fewer super spreading events, we also need to focus on almost every case to effectively reduce transmission. |
|
Dynamic trajectory of platelet-related indicators and survival of severe COVID-19
patients |
He, J, Wei, et al |
Crit Care |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to explore the association between platelet-related laboratory indicators and prognosis in critically ill
patients with COVID-19. All the severe and critically ill COVID-19 patients diagnosed in Huangshi City, Hubei Province, China, till 6 March, 2020, were recruited in this study. The platelet-related indicators included platelet count (PLT), mean platelet volume
(MPV), platelet distribution width (PDW), thrombocytocrit (PCT), and platelet large cell ratio (P-LCR). Baseline indicators were dichotomized by the median to low and high groups. For each platelet-related indicator with repeated examinations during hospitalization,
trajectory analysis was performed to cluster the patients based on the dynamic time-series trend of the corresponding indicator. The patients at admission with high PLT were associated with the preferred survival; however, patients with high PDW, high MPV,
or high P-LCR were significantly associated with the worse survival. On the other hand, dynamic trajectory of PLT couldn’t distinguish patients’ survival. However, a similar dynamic trajectory pattern with rapid acceleration in the first 2 weeks followed
by a considerable deceleration, was identified for MPV, PLCR, and PDW; patients with such pattern were significantly associated with about 2 to 5 times increased death hazard. |
|
Clinical characteristics of "re-positive" discharged COVID-19 pneumonia patients
in Wuhan, China |
He, S, Zhou, et al |
Sci Rep |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To analyze the clinical characteristics of re-positive discharged COVID-19 patients and find distinguishing markers.
The demographic features, clinical symptoms, laboratory results, comorbidities, co-infections, treatments, illness severities and chest CT scan results of 267 patients were collected from 1st January to 15th February 2020. COVID-19 was diagnosed by RT-PCR.
Clinical symptoms and nucleic acid test results were collected during the 14 days post-hospitalization quarantine. 30 out of 267 COVID-19 patients were detected re-positive during the post-hospitalization quarantine. Re-positive patients could not be distinguished
by demographic features, clinical symptoms, laboratory results, comorbidities, co-infections, treatments, chest CT scan results or subsequent clinical symptoms. However, re-positive rate was found to be correlated to illness severity, according the Acute Physiology
and Chronic Health Evaluation II (APACHE II) severity-of-disease classification system, and the confusion, urea, respiratory rate and blood pressure (CURB-65) score. Common clinical characteristics were not able to distinguish re-positive patients. However,
severe and critical cases classified high according APACHE II and CURB-65 scores, were more likely to become re-positive after discharge. |
|
Heald, AH, Stedman, et al |
Int J Clin Pract |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study developed a sequential assessment of the risk reduction provided by face coverings using a step-by-step
approach. Study shows that only 7.3% of all community-based infection risk is associated with public transport/retail outlets. The study models the number of COVID cases with infection rate (R) below 1, equal to 1 and above 1, as impacted by mandatory face-covering-wearing
policy. Although the policy on mandatory use of face coverings in retail outlets/on public transport may have been very well followed, it may be of limited value in reducing hospital admissions and deaths, at least at the time that it was introduced, unless
infections begin to rise faster than currently seen. The impact appears small compared to all other sources of risk, thereby raising questions regarding the effectiveness of the policy. |
|
|
Herbert, J, Horsham, et al |
JMIR Public Health Surveill |
Public health interventions*| Interventions de santé publique Public Health response|
Interventions de santé publique |
The primary aim of this study is to field test a prototype smart handwashing station deployed in a school setting during
the COVID-19 pandemic. The smart handwashing station was deployed for 10 days in a school setting in Australia during the COVID-19 pandemic. The smart handwashing station's electrical components remained operational during field testing and underwent robust
cleaning protocols each day. The handwashing station was used 1138 times during the field test and there was no COVID-19 transmission at the school during the testing. |
|
|
Ho, HY, Chen, et al |
Internet Interv |
Public Health response| Interventions de santé publique |
We examine the sociodemographic profiles of participants receiving different information sources and the impact of
various COVID-19-related information sources on public worry. A cross-sectional online survey with a total of 2007 participants aged 20 years and above recruited anonymously was conducted during the COVID-19 pandemic. The sociodemographic data, frequencies
at which participants received COVID-19-related information, the information sources (e.g., traditional media, interpersonal information exchange, and academic courses), and the levels of past, current, and anticipated worry about COVID-19 were assessed. The
COVID-19-related information from traditional media, internet media, and friends was associated with higher current worry, and the information from friends was associated with higher past worry. In contrast, participants who received information from academic
courses had lower past worry and anticipated worry (B ranged from -0.15 to -0.17). |
|
|
Hoffman, RL, Kania, et al |
J Med Chem |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The novel coronavirus disease COVID-19 that emerged in 2019 is caused by the virus SARS CoV-2 and named for its close
genetic similarity to SARS CoV-1 that caused severe acute respiratory syndrome (SARS) in 2002. Both SARS coronavirus genomes encode two overlapping large polyproteins, which are cleaved at specific sites by a 3C-like cysteine protease (3CL(pro)) in a post-translational
processing step that is critical for coronavirus replication. The 3CL(pro) sequences for CoV-1 and CoV-2 viruses are 100% identical in the catalytic domain that carries out protein cleavage. A research effort that focused on the discovery of reversible and
irreversible ketone-based inhibitors of SARS CoV-1 3CL(pro) employing ligand-protease structures solved by X-ray crystallography led to the identification of 3 and 4. Preclinical experiments reveal 4 (PF-00835231) as a potent inhibitor of CoV-2 3CL(pro) with
suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19. |
|
|
Hoiland, RL, Fergusson, et al |
Blood Adv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This Canadian study aimed to determine whether ABO blood groups are associated with different severities of COVID-19.
We conducted a multicenter retrospective analysis and nested prospective observational substudy of critically ill patients with COVID-19. We collected data pertaining to age, sex, comorbidities, dates of symptom onset, hospital admission, intensive care unit
(ICU) admission, mechanical ventilation, continuous renal replacement therapy (CRRT), standard laboratory parameters, and serum inflammatory cytokines. A higher proportion of COVID-19 patients with blood group A or AB required mechanical ventilation, and CCRT,
and had a longer ICU stay. compared with patients with blood group O or B. Blood group A or AB also had an increased probability of requiring mechanical ventilation and CRRT after adjusting for age, sex, and presence of ≥1 comorbidity. Inflammatory cytokines
did not differ between patients with blood group A or AB vs O or B for all cytokines. |
|
|
Hollingsworth, B, Okamoto, et al |
PLoS Comput Biol |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Here, we examine the results of stopped or failed non-immunizing control measures in endemic settings. By using a mathematical
model to compare the cumulative number of cases expected with and without control, we show that deployment of control can lead to a larger total number of infections, counting from the time that control started, than without any control-the divorce effect.
This result is directly related to the population-level loss of immunity resulting from non-immunizing controls and is seen in a variety of models when non-immunizing controls are used against an infection that confers immunity. Finally, we examine three control
plans for minimizing the magnitude of the divorce effect in seasonal infections and show that they are incapable of eliminating the divorce effect. While we do not suggest stopping control programs that rely on non-immunizing controls, our results strongly
argue that the accumulation of susceptibility should be considered before deploying such controls against endemic infections when indefinite use of the control is unlikely. We highlight that our results are particularly germane to endemic mosquito-borne infections,
such as dengue virus, both for routine management involving vector control and for field trials of novel control approaches, and in the context of non-pharmaceutical interventions aimed at COVID-19. |
|
|
Holt, GE, Batra, et al |
Sci Rep |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We aimed to find the effect of tocilizumab on mortality of COVID19 in a well-matched population cohort study. Comparison
of matched COVID-19 pneumonia patients found elevated IL-6 levels correlated with mortality that did not change with tocilizumab administration. Correlating mortality with increased IL-6 doesn't imply causality however lack of improvement by tocilizumab requires
further clinical trial alterations. |
|
|
Hong, W, Liu, et al |
Cyberpsychol Behav Soc Netw |
Public Health response| Interventions de santé publique |
This study aimed to examine the mediating role of rumination and the moderating role of mindfulness in the association
between social media exposure (SME) to COVID-19 information and psychological distress. The results from online questionnaire responses of 439 college students from two universities in Wuhan, Hubei Province, showed that rumination mediated the association
between SME and psychological distress. Furthermore, mindfulness was revealed as a protective factor that buffered the adverse effect of SME on psychological distress through rumination. These findings advance a better understanding of the formation process
of psychological symptoms during the COVID-19 pandemic and provide insights regarding effective interventions for adverse mental health consequences in college students. |
|
|
Hoque, MN, Rahman, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We hypothesized that the diversity of microbiome compositions and their genomic features are associated with different
pathological conditions of these human respiratory tract diseases (COVID-19 and non-COVID; URTI and COPD). We analyzed 21 whole metagenome sequences (WMS) including eleven COVID-19 (BD = 6 and China = 5), six COPD (UK = 6) and four URTI (USA = 4) samples to
unravel the diversity of microbiomes, their genomic features and relevant metabolic functions. Our metagenomics analyses revealed that COVID-19 had significant effect on the diversity and composition of respiratory tract microbiomes of human. Furthermore,
the COVID-19 associated microbiomes are rich in diversity, composition and functional capacity compared to the non-COVID respiratory disease (COPD and URTI)-related microbial communities. The identifiable changes in the microbiome diversity, composition and
associated genomic features demonstrated in this study might be associated with the development, treatment, and resolution of COVID-19 disease. The shared bacterial, archaeal and viral genera detected in this study suggest that respiratory tract disease associated
microbiomes could have a profound impact on the pathogenesis of SARS-CoV-2 infection and severity of the disease. Moreover, the predominantly abundant bacterial pathogens along with the archaea and bacterial viruses (phages) could have important contribution
for the generation of immune responses against viral attack, and this secondary microbial community might affect the outcome of COVID-19 disease. |
|
|
Development of Simple and Sensitive Score to Assess the Risk of Pneumonia in COVID-19
Patients |
Hormanstorfer, M, Ragusa, et al |
Rev Invest Clin |
Modelling/ prediction| Modélisation/prédiction Clinical data| Données cliniques Healthcare
Response | Réponse des soins de santé |
The objective of the study was to develop a sensitive and simple tool to assess the risk of pneumonia in COVID-19 patients
and thus select which patients would require a chest imaging study. One hundred and forty-eight patients were included, 71 (48%) received the diagnosis of pneumonia. The final clinical model included four variables: age >- 40 years, cough, absence of sore
throat, and respiratory rate >- 22. To create the score, we assigned values to the variables according to their ORs: 2 points for respiratory rate >- 22 and 1 point to the other variables. The AUC of the ROC curve was 0.80 (CI 95% 0.73-0.86). A cutoff value
of 2 showed a sensitivity of 95.7% and a specificity of 43.24%. |
|
Hu, W, Lv, et al |
Intern Emerg Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study presents the relationships between sodium balance disorders in COVID-19 patients, its clinical features,
implications, and the underlying causes. A total of 1,254 COVID-19 patients comprising 124 hyponatremic patients and 30 hypernatremic patients from three hospitals in Hubei, China, were enrolled. Sodium balance disorder, particularly hyponatremia, is a common
condition among hospitalized patients with COVID-19 in Hubei, China, and it is associated with a higher risk of severe illness and increased in-hospital mortality. |
|
|
Hu, X, Yan, et al |
Int J Hosp Manag |
Healthcare Response | Réponse des soins de santé |
The purpose of this paper is to explore in-depth how organizations can facilitate employees' deep compliance with these
procedures. Employing an instrumental case-study approach, we collected multi-level interview data and archival data in a small-medium sized restaurant in China. The findings reveal that employees' deep compliance with safety procedures includes a four-stage
psychological process, and this process is underpinned by both management safety practices and organizational crisis strategies. As the hospitality industry starts to exit lockdown and ramp up operations, this study offers theoretical and practical insights
on how organizations in hospitality can protect the health and safety of their employees and the broader community. |
|
|
Hu, X, Zhu, et al |
Clin Chim Acta |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
A series of reference materials calibrated by droplet digital PCR (ddPCR) and 57 clinical samples were used to evaluate
the clinical performance of six single-, dual-, triple-target SARS-CoV-2 nucleic acid detection kits based on RT-qPCR. The dual-target kits, kit B and kit C had the highest and the lowest detection sensitivity, which was 125 copies/mL and 4000 copies/mL, respectively.
Among the 57 clinical samples from patients with COVID-19, 47 were tested positive by the kit B, while 35, 29, 28, 30, and 29 were found positive by the kits A, C, D, E, and F, respectively. The number of targets in a detection kit is not a key factor affecting
sensitivity, while the amount of sample loading may influence the performance of a detection kit. |
|
|
Huang, HD, Jneid, et al |
Cardiol Ther |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We sought to determine the effectiveness and safety of hydroxychloroquine-azithromycin (HCQ-AZM) therapy in hospitalized
patients with COVID-19. retrospective cohort study of 613 patients hospitalized (integrated health system involving three hospitals) for RT-PCR-confirmed COVID-19 infection between March 1, 2020 and April 25, 2020. Intervention was treatment with HCQ-AZM in
hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Outcomes of interest were in-hospital all-cause mortality, cardiovascular mortality, pulseless electrical activity (PEA) arrest, non-lethal arrhythmias, and
length of hospital stay. Secondary measures included in-hospital corrected QT (QTc) interval parameters and serum biomarkers levels. In this propensity-matched study, there was no difference in in-hospital mortality, life-threatening arrhythmias, or incidence
of PEA arrest between the HCQ-AZM and untreated control groups. QTc intervals were longer in patients receiving HCQ-AZM, but only one patient developed drug-related ventricular tachycardia. |
|
|
Huang, J, Li, et al |
Am J Case Rep |
Transmission Clinical data| Données cliniques |
In this case series, we report clinical and imaging characteristics of 3 patients (A, B, and C) infected with COVID-19.
In an exposure-tracking epidemiological investigation, we found that it is possible that Patient A transmitted the infection to her treating physician, Patient B. Patient B then likely transmitted the infection to her family member, Patient C. From the chest
CT studies and clinical characteristics, we postulate that the virulence did not decrease during human-to-human transmission. In previous studies, patients with the virus infection had changes in chest CT; however, we found that during the early stages of
this disease, some patients (Patient C) may have normal chest CT scans and laboratory studies. Most importantly, we found that IL-6 levels were highest and lymphocyte count was lowest in those with more severe infection. |
|
|
Surveillance
of Coronavirus Disease 2019 (COVID-19) Testing in Clinical Laboratories in Korea |
Huh, HJ, Hong, et al |
Ann Lab Med |
Healthcare Response | Réponse des soins de santé |
In response to the ongoing coronavirus disease 2019 (COVID-19) pandemic, an online laboratory surveillance system was
established to monitor severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) real-time reverse transcription-PCR (rRT-PCR) testing capacities and results. SARS-CoV-2 rRT-PCR testing data were collected from 97 clinical laboratories, including 84 medical
institutions and 13 independent clinical laboratories in Korea. We assessed the testing capacities to utilize SARS-CoV-2 rRT-PCR based on surveillance data obtained from February 7th to June 4th, 2020 and evaluated positive result characteristics according
to the reagents used and sample types. A total of 1,890,319 SARS-CoV-2 rRT-PCR testing were performed, 2.3% of which were positive. Strong correlations were observed between the envelope (E) gene and RNA-dependent RNA polymerase (RdRp)/nucleocapsid (N) genes
threshold cycle (Ct) values for each reagent. No statistically significant differences in gene Ct values were observed between the paired upper and lower respiratory tract samples, except in the N gene for nasopharyngeal swab and sputum samples. Our study
showed that clinical laboratories in Korea have rapidly expanded their testing capacities in response to the COVID-19 outbreak, with a peak daily capacity of 34,193 tests. Rapid expansion in testing capacity is a critical component of the national response
to the ongoing pandemic. |
|
PMC7280108; High rates of 30-day mortality in patients with cirrhosis and COVID-19 |
Iavarone, M, D'Ambrosio, et al |
J Hepatol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to evaluate the impact of COVID-19 on the clinical outcome of patients with cirrhosis. In this multicentre
retrospective study, 50 patients with cirrhosis and a confirmed SARS-CoV-2 infection were enrolled between 1 and 31 March 2020. Clinical and biochemical data at diagnosis of COVID-19 and at the last outpatient visit were obtained through review of medical
records. At diagnosis, 64% of patients presented fever, 42% shortness of breath/polypnea, 22% encephalopathy, 96% needed hospitalization or a prolonged stay if already in hospital. Respiratory support was necessary in 71%, 52% received antivirals, 80% heparin.
Serum albumin significantly decreased, while bilirubin, creatinine and prothrombin time significantly increased at COVID-19 diagnosis compared to last available data. The proportion of patients with a model for end-stage liver disease (MELD) score ≥15 increased
from 13% to 26%, acute-on-chronic liver failure and de novo acute liver injury occurred in 14 and 10 patients, respectively. Seventeen patients died after a median of 10 days from COVID-19 diagnosis, with a 30-day-mortality rate of 34%. The severity of lung
and liver diseases independently predicted mortality. In patients with cirrhosis, mortality was significantly higher in those with COVID-19 than in those hospitalized for bacterial infections. |
|
Ibrahim, OM, Ibrahim, et al |
J Telemed Telecare |
Healthcare Response | Réponse des soins de santé |
This study aimed to examine differences in rates and types of pharmacist interventions related to COVID-19 and medication
dispensing errors (MDEs) across community pharmacies with and without telepharmacy services. The test (telepharmacy) group pharmacies provided pharmaceutical care to 19,974 patients, of whom 6371 (31.90%) and 1213 (6.07%) were probable and confirmed cases
of COVID-19, respectively. The control group pharmacies provided care to 9151 patients, of whom 1074 (11.74%) and 33 (0.36%) were probable and confirmed cases of COVID-19, respectively. Rates of MDEs and their subcategories, prescription-related errors and
pharmacist counselling errors across pharmacies with telepharmacy versus those without remote services were 15.81% versus 19.43% (p 0.05), respectively. |
|
|
Inada, H, Ashraf, et al |
Inj Prev |
Public Health response| Interventions de santé publique |
Between March and May 2020, Japan experienced a lockdown due to the COVID-19 crisis. Empty roads possibly triggered
speed-related traffic violations that caused fatal motor vehicle collisions (MVCs). Using police data on the monthly number of fatal MVCs between January 2010 and February 2020 in which motor vehicle drivers were at fault, we forecasted the numbers of fatal
MVCs due to the speed-related violations during the lockdown and compared these with those observed. We also compared the observed to forecasted using the ratio of the number of speed-related fatal MVCs to that of non-speed related fatal MVCs. The observed
numbers of speed-related fatal MVCs were within the 95% CIs of the forecasted numbers. The observed ratio was higher than the forecasted ratio in April (p=0.016). In the second month of the lockdown, drivers were more likely to commit speed-related violations
that caused fatal MVCs than before the lockdown. |
|
|
Iqbal, MR, Dhahri, et al |
Ann Med Surg (Lond) |
Healthcare Response | Réponse des soins de santé |
Our hospital utilised local private hospital as a dedicated cold site (CS) for urgent elective surgery during the peak
of the COVID-19 pandemic. We aim to analyse the outcomes at this dedicated cold site. A total of 153 patients were operated at the CS over the study period with a median age of 57 years (Interquartile range, IQR 47-70). 62% were females and 82% had a Body
Mass Index (BMI) less than 30. 73% of the operations were performed for cancer. 59% of the surgeries were graded as intermediate and 26% as major or complex. There was no mortality at 30 days from COVID-19 or non COVID-19 causes. There was only 1 (0.65%) readmission.
7 patients (4.57%) developed complications. 1 (0.65%) patient was diagnosed with COVID-19 in the postoperative period while 3 had COVID-19 symptoms but were tested negative. |
|
|
Irigoyen-Camacho, M, Velazquez-Alva, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
The objective of this study was to assess the role of income level (IL) and the perception of older adults, regarding
COVID-19 susceptibility and severity, on adopting stay-at-home preventive behavior during the first week of the outbreak in Mexico. Participants in this cross-sectional study were urban community dwellers, aged ≥ 65 years from Mexico City. A total of 380 interviews
were conducted over the phone. The mean respondent age was 72.9 years, and 76.1% were women. Over half (54.2%) of the participants perceived their susceptibility to COVID-19 as very low or low. Similarly, 33.4% perceived COVID-19 severity as being very low
or low, and 57.6% had decided to stay at home: this behavior was associated with IL (β = 1.05, p < 0.001), and its total effect was partially mediated (15.1%) by perceived severity. Educational attainment was also associated with staying at home (β = 0.10,
p = 0.018) and its total effect was partially mediated (15.0%) by perceived susceptibility. Interventions aimed at low income and less educated older adults should be developed to improve preventive behaviors in this vulnerable group during the COVID-19 pandemic. |
|
|
Ishikawa, Y, Hifumi, et al |
SN Compr Clin Med |
Healthcare Response | Réponse des soins de santé |
Here, we investigated the number of patients in Emergency Departments (EDs) in three major hospitals in Tokyo, and
also briefly discussed about the relationship between the number of patients in EDs and health system's capacity. We compared the number of patients in 2020 to the average number of patients from 2016 to 2019. Numbers were compared in three periods: before
the first COVID-19 patient was reported in Japan (January 1 to January 16), after the government encouraged social distancing (February 26 to March 10), and the interval between them (January 17 to February 25). The average number of daily patients in 2020
(n = 122) decreased by 17% compared to the average number of patients from 2016 to 2019 (n = 144) (Mann-Whitney test, p < 0.001). |
|
|
Islam, Md Shariful, Hoque, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission |
In this article, we propose to integrate the Unscented Kalman Filter (UKF) with classic SIRD model to explain the epidemic
evolution of individual districts in Bangladesh . We show that UKF-SIRD model results in a robust prediction of the transmission dynamics for 1-4 months. Then we apply the robust UKF-SIRD model over different regions in Bangladesh to estimates the course of
the epidemic. Our analysis demonstrate that in addition to the densely populated areas, industrial areas and popular tourist spots are in the risk of higher COVID-19 transmission. |
|
|
Assessment of SARS-CoV-2 in the Cerumen of COVID-19-Positive Patients |
Islamoglu, Y, Bercin, et al |
Ear Nose Throat J |
Clinical data| Données cliniques |
Objective: To evaluate the presence of SARS-CoV-2 virus in the cerumen of patients with COVID-19. Sixty COVID-19 patients
with cerumen in their external auditory canals were included in the study. SARS-CoV-2 was not detected in the cerumen polymerase chain reaction (PCR) samples of any of the 60 patients with positive nasopharyngeal/oropharyngeal swabs. |
|
Objective evaluation of the nasal mucosal secretion in COVID-19
patients with anosmia |
Islamoglu, Y, Gemcioglu, et al |
Ir J Med Sci |
Clinical data| Données cliniques |
Aims: To evaluate nasal mucosal secretion objectively in COVID-19 patients with anosmia. Fifty-two COVID-19 patients
with anosmia and 51 healthy individuals included. We found no difference between healthy individuals. According to our study, SARS-CoV-2 causes anosmia without causing nasal mucosal inflammation. |
|
Jahrsdörfer, B, Kroschel, et al |
J Infect Dis |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study provides a comparative validation of four anti-SARS-CoV-2 platforms. All platforms showed significant correlations
with a SARS-CoV-2 plaque-reduction-neutralization test, with highest sensitivities for the Euroimmun and the Roche platforms, suggesting their preferential use for screening of persons at increased risk of SARS-CoV-2 infections. |
|
|
Janssen, LHC, Kullberg, et al |
PLoS One |
Public Health response| Interventions de santé publique |
In this ecological momentary assessment study, we investigated if the COVID-19 pandemic affected positive and negative
affect of parents and adolescents and parenting behaviors (warmth and criticism). Multilevel analyses showed that only parents’ negative affect increased as compared to the period before the pandemic, whereas this was not the case for adolescents’ negative
affect, positive affect and parenting behaviors (from both the adolescent and parent perspective). In general, intolerance of uncertainty was linked to adolescents’ and parents’ negative affect and adolescents’ positive affect. However, Intolerance of uncertainty,
nor any pandemic related characteristics (i.e. living surface, income, relatives with COVID-19, hours of working at home, helping children with school and contact with COVID-19 patients at work) were linked to the increase of parents’ negative affect during
COVID-19. |
|
|
Geospatial Distribution of Neurosurgeons Age
60 and Above Relative to the Spread of COVID-19 |
Jella, TK, Desai, et al |
World Neurosurg |
Epidemiology| Épidémiologie |
Objective: To perform an ecological study in order to analyze the geospatial distribution of neurosurgeons ≥ 60 years
old and compare these data with the spread of COVID-19 across the; U.S. As of July 5, 2020, the 10 states with the highest number of COVID-19 cases showed older neurosurgical workforce proportions (the proportion of active surgeons aged 60 years or older)
ranging from 20.6% to 38.9%. Among states with the highest number of COVID-19 deaths, the older workforce proportion ranged from 25.0% to 43.4%. Connecticut demonstrated the highest with 43.4% of neurosurgeons 60 years or older. |
|
CD45: a critical regulator in immune cells to predict severe
and non-severe COVID-19 patients |
Jin, M, Shi, et al |
Aging (Albany NY) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to distinguish between severe and non-severe patients in early diagnosis. The results showed
that the mortality of COVID-19 patients increased accompanied by age. Host factors CRP, IL-1β, hs-CRP, IL-8, and IL-6 levels in severe pneumonia patients were higher than in non-severe patients. CD3, CD8, and CD45 counts were decreased in COVID-19 patients.
The results of this study suggest that the K-values of CD45 might be useful in distinguishing between severe and non-severe cases. The results confirmed that immune system dysfunction is a potential cause of mortality following COVID-19 infection, particularly
for the elderly. |
|
Extremely high-dose insulin requirement in a
diabetic patient with COVID-19: a case report |
Jornayvaz, FR, Assouline, et al |
BMC Endocr Disord |
Clinical data| Données cliniques |
Here, we report the case of an extreme and transitory insulin requirement episode in a type 2 diabetic patient presenting
an acute respiratory distress syndrome caused by SARS-CoV-2. |
|
Sociodemographic Predictors of SARS-CoV-2 Infection in Obstetric Patients,
Georgia, USA |
Joseph, NT, Stanhope, et al |
Emerg Infect Dis |
Epidemiology| Épidémiologie |
We conducted a cohort study to determine sociodemographic risk factors for severe acute respiratory syndrome coronavirus
2 infection among obstetric patients in 2 urban hospitals in Atlanta, Georgia, USA. Prevalence of infection was highest among women who were Hispanic, were uninsured, or lived in high-density neighborhoods. |
|
Joshi, AU, Lewiss, et al |
JMIR Mhealth Uhealth |
Healthcare Response | Réponse des soins de santé |
This study aims to describe the expansion and results of using a telehealth program to increase access to care while
minimizing additional potential exposures during the early period of the COVID-19 pandemic. From March 8, 2020, to April 11, 2020, 4663 patients were screened using telehealth, representing a surge in visit volume. There were 1521 patients sent to mobile testing
sites, and they received a telephone call from a centralized call center for results. Of the patients who were tested, nearly 20% (n=301) had a positive result. Our model demonstrates how using telehealth for a referral to central testing sites can increase
access to community-based care, decrease clinician exposure, and minimize the demand for personal protective equipment. |
|
|
PMC7553124; Outcomes of Ayurvedic care in a
COVID-19 patient with hypoxia - A Case Report |
Joshi, JA, Puthiyedath, et al |
J Ayurveda Integr Med |
Clinical data| Données cliniques |
This paper reports for the first time, the outcomes of Ayurvedic intervention in a COVID-19 patient with severe hypoxia
requiring supportive oxygen therapy. The patient showed clinical improvement within a day of administration of Ayurvedic medicines and was able to talk, eat, and sit on the bed without breathing difficulty and her SPO2 became stable. In the next two days,
she was asymptomatic without oxygen support and was discharged from the hospital in the following week. |
|
How did Different Generations Cope with the COVID-19 Pandemic? Early Stages
of the Pandemic in Spain |
Justo-Alonso, A, García-Dantas, et al |
Psicothema |
Public Health response| Interventions de santé publique |
The aim of this study is to examine the role of age in the early psychological responses to the pandemic in a Spanish
community sample. 3,524 participants were included. Participants aged between 18 and 33 years old showed more hyperactivation and evitation, were more depressed, anxious and stressed. Those aged between 26 and 33 years old showed more intrusion. Those aged
between 18 and 25 years old suffered more sleep disturbances, claustrophobia and somatization and maintained worse routines. Elderly people showed better psychological responses in general. |
|
PMC7534756; Isfahan and Covid-19: Deep spatiotemporal
representation |
Kafieh, R, Saeedizadeh, et al |
Chaos Solitons Fractals |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this study, deep learning is selected as a powerful tool for forecasting this epidemic in Isfahan. Different models
are utilized, and the best performance is found to be for a tailored type of long short-term memory (LSTM). The future trajectory of the outbreak in Isfahan is forecasted with the proposed model. The paper demonstrates the positive effect of adding Social
Determinant of Health (SDH) in pandemic prediction. Furthermore, the effectiveness of different SDHs is discussed, and the most effective terms are introduced. The method expresses high ability in both short- and long- term forecasting of the outbreak. |
|
Kalai, FE, Çınar, et al |
J Mol Struct |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study, we present the synthesis of novel pyridazin-3(2H)-one derivative namely (E)-4-(4-methylbenzyl)-6-styrylpyridazin-3(2H)-one
(MBSP). The chemical structure of MBSP was characterized using spectroscopic techniques such as FT-IR, (1)H NMR, (13)C NMR, UV-Vis, ESI-MS, and finally, the structure was confirmed by single X-ray diffraction studies. The DFT calculation was performed to compare
the gas-phase geometry of the title compound to the solid-phase structure of the title compound. Furthermore, a comparative study between theoretical UV-Vis, IR, (1)H- and (13)C NMR spectra of the studied compound and experimental ones have been carried out.
The thermal behavior and stability of the compound were analyzed by using TGA and DTA techniques which revealed that the compound is thermostable up to its melting point. Finally, the in silico docking and ADME studies are performed to investigate whether
MBSP is a potential therapeutic for COVID-19. |
|
|
Kardeş, S, Kuzu, et al |
Rheumatol Int |
Public Health response| Interventions de santé publique |
To evaluate the public interest in rheumatic diseases during the coronavirus disease 2019 (COVID-19) pandemic. Google
Trends was queried to analyze search trends in the United States for numerous rheumatic diseases and also the interest in a rheumatologist. Three 8-week periods in 2020 ((March 15–May 9), (May 10–July 4), and (July 5–August 29)) were compared to similar periods
of the prior 4 years (2016–2019). Compared to a similar time period between 2016 and 2019, a significant decrease was found in the relative search volume for more than half of the search terms during the initial March 15–May 9, 2020 period. However, this trend
appeared to reverse during the July 5–August 29, 2020 period where the relative volume for nearly half of the search terms were not statistically significant compared to similar periods of the prior 4 years. There was a significant decrease in relative search
volume for many rheumatic diseases between March 15 and May 9, 2020 when compared to similar periods during the prior 4 years. However, the trends reversed after the initial period ended. There was an increase in relative search for the term “rheumatologist”
between July and August 2020 suggesting the need for rheumatologists during the COVID-19 pandemic. |
|
|
Increased odds ratio for Covid 19 in patients with recurrent aphthous
stomatitis |
Katz, J, Yue, et al |
J Oral Pathol Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We used the i2b2 platform of hospital patient’s registry to determine the odds ratio for Covid 19 in patients that
were diagnosed with recurrent aphthous stomatitis, an entity restricted to the oral cavity. The overall odds ratio for Covid 19 in patients with recurrent aphthous stomatitis before adjustments was 14 and after adjustment for gender, race and age 13.9, 6.5
and 2.93 respectively. The odds ratio remained increased after adjustments of the co‐ morbidities: respiratory disease, endocrine disease, obesity, diabetes, circulatory disease and smoking and were 3.66, 7.46, 4.6, 10.54, 7.37, and 7.52 respectively. When
adjusted for recurrent aphthous stomatitis, respiratory disease had an odd ratio of 8.56 to be associated with Covid 19.African American race and age groups 18‐34 were additional significant risk factors. |
|
Kaushal, Sunjay, Khan, et al |
medRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We conducted a case-control study of critically ill patients with laboratory-confirmed COVID-19. atients (n=9) were
administered with up to 3 infusions of intravenous (IV) mesenchymal stem cell (MSC) and compared to a local extracorporeal membrane oxygenation (ECMO) control group (n=31). MSC infusions (12 patients) were well tolerated and no side effects occurred. Of ECMO
patients receiving MSC infusions, 2 out of 9 died (22.2%; 95%CI: 2.8%, 60.0%) compared with a mortality of 15 of 31 (48.4%; 95%CI: 30.2%, 66.9%; p = 0.25) in the ECMO control group. Isolated plasma exosomes containing the SARS-COV-2 Spike protein decreased
after MSC infusions between day 14 or 21 after administration (p=0.003 and p=0.005, respectively) and was associated with a decrease in COVID-19 IgG Spike protein titer at same time points (p = 0.006 and p=0.007, respectively). Control ECMO patients receiving
convalescent plasma did not clear COVID-19 IgG over the same time frame. |
|
|
Kavsak, PA, Mondoux, et al |
CJC Open |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
We performed a retrospective chart review of COVID-19 patients admitted to hospitals in the city of Hamilton in order
to explore the performance characteristics of high-sensitivity cardiac troponin (hs-cTn) level, the clinical chemistry score (CCS) and the CCS with urea (CCUS) to predict in-hospital death. The CCUS had the highest AUC for in-hospital death (0.81; 95% confidence
interval [CI]:0.65-0.92), higher than hs-cTnI alone (0.69; 95% CI:0.52-0.83) (p=0.01;). A CCUS ≤2 yielded a sensitivity=92% (95% CI:64-99) and a CCUS >5 a specificity=92% (95%CI:74-99). |
|
|
Kazan Kızılkurt, O, Yılmaz, et al |
Perspect Psychiatr Care |
Public Health response| Interventions de santé publique |
Purpose: To investigate health anxiety‐related factors in the early stages of pandemic in Turkey. This study included
1046 participants who responded to the online survey anonymously between 28 March and 04 April 2020. Demographic data, post-pandemic attitudes towards the elderly and precaution‐taking behaviors were health anxiety‐related factors. The main predictors of the
health anxiety were the level of hopelessness, perception of self, time spent on social media, and following COVID‐19 pandemic‐related news. |
|
|
Kazi, R, Evankovich, et al |
Telemed J E Health |
Healthcare Response | Réponse des soins de santé |
Objective: To provide quantitative data about the use of teledermatology. A total of 951 visits (36.2%) were asynchronous
whereas 1,672 visits (63.8%) were synchronous. Only 131 (<5%) visits required an acute in-person follow-up. The diagnosis of acne was more frequent with asynchronous visits (p < 0.002, Bonferroni corrected). Antibiotics and nonretinoid acne medications were
prescribed more with asynchronous visits, whereas immunomodulators and biologics were more commonly prescribed with synchronous visits (p < 0.02, Bonferroni corrected). Providers at our institution were split on preferred mode (54.2% synchronous, 45.8% asynchronous);
however, synchronous visits were preferred for complex medical dermatology patients and return patients (p < 0.05). |
|
|
Keller, E, Brandi, et al |
Stroke |
Clinical data| Données cliniques |
We evaluated 32 consecutive critically ill patients with COVID-19 treated at a tertiary care center from March 9 to
April 3, 2020, for concomitant severe central nervous system involvement. Of 32 critically ill patients with COVID-19, 8 (25%) had severe central nervous system involvement. Two presented with lacunar ischemic stroke in the early phase and 6 with prolonged
impaired consciousness after termination of analgosedation. In all but one with delayed wake-up, neuroimaging or autopsy showed multiple cerebral microbleeds, in 3 with additional subarachnoid hemorrhage and in 2 with additional small ischemic lesions. In
3 patients, intracranial vessel wall sequence magnetic resonance imaging was performed for the first time to our knowledge. All showed contrast enhancement of vessel walls in large cerebral arteries, suggesting vascular wall pathologies with an inflammatory
component. Reverse transcription-polymerase chain reactions for SARS-CoV-2 in cerebrospinal fluid were all negative. No intrathecal SARS-CoV-2-specific IgG synthesis was detectable. |
|
|
Keogh-Brown, M, Jensen, et al |
SSM Popul Health |
Economics | Économie |
We estimate the potential impact of COVID-19 on the United Kingdom economy, including direct disease effects, preventive
public actions and associated policie. Our simulations indicate that, assuming a clinical attack rate of 48% and a case fatality ratio of 1.5%, COVID-19 alone would impose a direct health-related economic burden of £39.6bn (1.73% of GDP) on the UK economy.
Mitigation strategies imposed for 12 weeks reduce case fatalities by 29%, but the total cost to the economy is £308bn (13.5% of GDP). Suppressing the pandemic over a longer period of time may reduce deaths by 95%, but the total cost to the UK economy also
increases to £668bn (29.2% of GDP). Whilst public actions are necessary to minimise mortality, the duration of school and business closures are key to determining the economic cost. |
|
|
Kewan, Tariq, Alwakeel, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This multicenter retrospective study describes the factors that might predict venous thromboembolism (VTE) diagnosis
in 219 critically-ill COVID-19 patients. Of all included patients, 57 (26%) patients were diagnosed with VTE. At baseline, patients in the VTE cohort were more likely to be male and to age between 50-70 years. The optimum cutoff value for D-dimer to predict
VTE in all patients was 2000 ng/ml (sensitivity of 86·0% and NPV of 91·3%). A total of 36 (16%) deaths occurred during the follow-up period. Elevated D-dimer (>2000 mg/ml, OR 1·7 [0·8-3·8]) was not associated with an increased risk of death. The use of intensified
prophylactic anticoagulation was not associated with better survival outcomes. |
|
|
Khairkhah, N, Aghasadeghi, et al |
PLoS One |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
A computational approach was adopted to identify multiepitope vaccine candidates against SARS-CoV-2 based on S, N and
M proteins being able to elicit both humoral and cellular immune responses. We proposed three different constructs based on linear B-cell, CTL and HTL epitopes. We found one putative CTL epitope, S360-368 related to receptor-binding domain (RBD) region for
S protein. The predicted epitopes were non-allergen and showed a high quality of proteasomal cleavage and Tap transport efficiency and 100% conservancy within four different clades of SARS-CoV-2. For CTL and HTL epitopes, the highest population coverage of
the world’s population was calculated for S27-37 with 86.27% and for S196-231, S303-323, S313-330, S1009-1030 and N328-349 with 90.33%, respectively. We identified overall 10 discontinuous B-cell epitopes for three multiepitope constructs. All three constructs
showed strong interactions with TLRs 2, 3 and 4 supporting the hypothesis of SARS-CoV-2 susceptibility to TLRs 2, 3 and 4 like other Coronaviridae families. |
|
|
Khan, AA, AlRuthia, et al |
Int J Environ Res Public Health |
Epidemiology| Épidémiologie Economics | Économie |
Objectives: Assess the survival of hospitalized coronavirus disease 2019 (COVID-19) patients across age groups, sex,
use of mechanical ventilators (MVs), nationality, and intensive care unit (ICU) admission in the Kingdom of Saudi Arabia. Micro-costing was used to estimate the direct medical costs associated with hospitalization per patient. The number of included patients
with complete status (discharge or death) was 1422. The overall 14-day survival was 0.699 (95%CI: 0.652–0.741). Older adults (>70 years) (HR = 5.00, 95%CI = 2.83–8.91), patients on MVs (5.39, 3.83–7.64), non-Saudi patients (1.37, 1.01–1.89), and ICU admission
(2.09, 1.49–2.93) were associated with a high risk of mortality. The mean cost per patient (in SAR) for those admitted to the general Medical Ward (GMW) and ICU was 42,704.49 ± 29,811.25 and 79,418.30 ± 55,647.69, respectively. |
|
|
Khan, AT, Khalid, et al |
J Biomol Struct Dyn |
Clinical data| Données cliniques |
This article provides a computational and bioinformatics-based analysis of ACE2 with an objective of providing further
insight into the earnest efforts to determine its true position in COVID-19 pathology. The results of this study show that ACE2 has strikingly low expression in healthy human lung tissue and was absent from the list of differentially expressed genes. However,
when transcription factors were analyzed, we found a significant upregulation of FOS and downregulation of FOXO4 and FOXP2. Moreover, the miRNA prediction analysis revealed that miR-1246, whose upregulation has been experimentally established to be a cause
of acute respiratory distress syndrome (ARDS), was found to be targeting the coding DNA sequence (CDS) of ACE2. |
|
|
A biological profile for diagnosis and outcome of COVID-19 patients |
Khourssaji, M, Chapelle, et al |
Clin Chem Lab Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to identify Coronavirus Disease 2019 (COVID-19) biomarkers, to investigate their correlation
with disease severity and to evaluate their usefulness for follow-up. Fifty patients diagnosed with SARS-Cov-2 were included. Blood parameters in COVID-19 patients at admission showed increased C-reactive protein (CRP) (100%), ferritin (92%), lactate dehydrogenase
(LDH) (80%), white blood cell (WBC) count (26%) with lymphopenia (52%) and eosinopenia (98%). There were significant differences in levels of CRP, ferritin, D-dimers, fibrinogen, lymphocyte count, neutrophil count and neutrophil-to-lymphocyte ratio (NLR).
Mapping of biomarker’s kinetics distinguished early and late parameters. CRP, ferritin, LDH, lymphopenia and eosinopenia were present upon admission with a peak at the first week. Late biomarkers such as anemia, neutrophilia and elevated liver biomarkers appeared
after one week with a peak at three weeks of hospitalization. |
|
Kılınç, T, Sis Çelik, et al |
Perspect Psychiatr Care |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to determine the relationship between the social support and psychological resilience levels
perceived by nurses in Turkey during the coronavirus disease‐2019 (COVID‐19) pandemic. The level of social support perceived by the nurses during the COVID‐19 pandemic was very good, and the perceived psychological resilience level was moderately good. Moreover,
their psychological resilience was found to increase as the social support perceived by them increased. |
|
|
Effects of Storage Temperature and Media/Buffer
for SARS-CoV-2 Nucleic Acid Detection |
Kim, N, Kwon, et al |
Am J Clin Pathol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study aims to assess how some conditions, such as storage period, temperature, media or buffer, and sample types,
affect the results of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-qPCR. As a result of examining confirmed patient samples, RT-qPCR results were not significantly affected by 2°C to 8°C storage until after 7 days. When stored at 20°C to
22°C or above 35°C, the results were affected negatively even after 1 day. Higher storage temperatures resulted in a lower probability of detecting viral nucleic acids because of degradation. Samples stored in pH-controlled media or buffer were more stable
than those stored in non-buffer states. |
|
Finding the 'right' GP: a qualitative study of the experiences
of people with long-COVID |
Kingstone, T, Taylor, et al |
BJGP Open |
Public Health response| Interventions de santé publique |
Aim To explore experiences of people with persisting symptoms following COVID-19 infection, and their views on primary
care support received .This article reports analysis of 24 interviews. The main themes include: the ‘hard and heavy work’ of enduring and managing symptoms and accessing care; living with uncertainty, helplessness and fear, particularly over whether recovery
is possible; the importance of finding the 'right' GP (understanding, empathy, and support needed); and recovery and rehabilitation: what would help? |
|
Kirby, RichardS, Kirby, et al |
medRxiv |
Epidemiology| Épidémiologie |
Design, Setting, and Participants: Retrospective cross-sectional study of patients in two nursing home facilities (one
urban, one suburban) from 3/16/2020 to 7/13/2020 with positive COVID-19 PCR assays. 56 patients met the inclusion criteria for the study. Mortality was 14.3% while the New Jersey nursing home average mortality rate was 28.3% as of August 2020. Our patient
cohort had a 49.5% reduction in mortality compared to the state average. In our overall cohort, none of the clinical parameters correlated with COVID-19 mortality using chi-squared analysis. In the 56 patient cohort, average clinical and laboratory findings
were 74.0 years, 62.5% female, 28.5% uncontrolled hypertension, BMI 25.6, hemoglobin A1c 6.4, TSH 2.4, vitamin B12 568.3, folate 12.4, iron 47.8, total iron binding capacity 271.8, hemoglobin 11.6, albumin 3.5, triglycerides 100.3, total cholesterol 133.5,
HDL 40.9, and BUN to Creatinine ratio 22.2:1. Logistic multivariate regression analyses failed to demonstrate clinically significant correlation with COVID-19 mortality. In the urban nursing home, BUN to creatinine ratio exceeding 20:1 was the only factor
that showed statistical significance to COVID-19 mortality (p = 0.03). In the suburban nursing home, age over 80 was the only clinical factor demonstrating statistical significance to COVID-19 mortality (p = 0.003). |
|
|
Kiuchi, K, Kishi, et al |
Asia Pac J Public Health |
Public Health response| Interventions de santé publique |
A web survey was conducted among 1500 people. The results showed that differences in ethnicity, concurrence of physical
or mental illness, the nature of those living in the same household (eg, high-risk individuals or preschoolers), household income, and employment status were associated with differences in physical and mental health, psychological distress, and/or suicidal
ideation. Differences related to the degree of the spread of the infection in the area of residence, degree of engagement in essential work, and frequency of contact with others during normal times were not found. |
|
|
Unusual zwitterionic catalytic site of SARS-CoV-2 main protease
revealed by neutron crystallography |
Kneller, DW, Phillips, et al |
J Biol Chem |
Coronavirology| Coronavirologie |
we present the room-temperature neutron structure of 3CL Mpro, which allowed direct determination of hydrogen atom
positions and, hence, protonation states in the protease. We observe that the catalytic site natively adopts a zwitterionic reactive form where Cys145 is in the negatively charged thiolate state, and His41 is doubly protonated and positively charged, instead
of the neutral unreactive state usually envisaged. The neutron structure also identified the protonation states, and thus electrical charges, of all other amino acid residues and revealed intricate hydrogen bonding networks in the active site cavity and at
the dimer interface. The fine atomic details present in this structure were made possible by the unique scattering properties of the neutron, which is an ideal probe for locating hydrogen positions and experimentally determining protonation states at near-physiological
temperature. |
|
Knisely, A, Zhou, et al |
Ann Surg |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective: To evaluate the perioperative morbidity and mortality of patients with COVID-19 who undergo urgent and
emergent surgery. Among 468 subjects, 36 (7.7%) had confirmed COVID-19. Among those with COVID-19, 55.6% were detected preoperatively and 44.4% postoperatively. Before the routine preoperative COVID-19 laboratory screening, 7.7% of cases were diagnosed preoperatively
compared to 65.2% after institution of screening (P = 0.0008). The perioperative mortality rate was 16.7% in those with COVID-19 compared to 1.4% in COVID-19 negative subjects [aRR = 9.29; 95% confidence interval (CI), 5.68–15.21]. Serious complications were
identified in 58.3% of COVID-19 subjects versus 6.0% of controls (aRR = 7.02; 95%CI, 4.96–9.92). Cardiac arrest, sepsis/shock, respiratory failure, pneumonia, acute respiratory distress syndrome, and acute kidney injury were more common in those with COVID-19.
The intensive care unit admission rate was 36.1% in those with COVID-19 compared to 16.4% of controls (aRR = 1.34; 95%CI, 0.86–2.09). |
|
|
Knoll, RL, Klopp, et al |
Pediatr Infect Dis J |
Epidemiology| Épidémiologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé |
An outbreak of SARS-CoV-2 was detected and contained in a pediatric ICU (PICU). Positive HCWs were sent into quarantine.
Containment measures were implemented including wearing of surgical-masks, physical distancing and systematic testing. Among 432 HCWs, 91 (25%) were tested. Forty-five percent reported symptoms corresponding to characteristics of COVID-19. Of those, only 19,5%
(8 HCWs) were tested positive for SARS-CoV-2. No infection occurred outside the PICU. After the implementation of containment measures, viral transmission was stopped. |
|
|
Kohns Vasconcelos, M, Renk, et al |
Eur J Pediatr |
Healthcare Response | Réponse des soins de santé |
Between February and May 2020, during the first wave of the COVID-19 pandemic, paediatric emergency departments in
12 European countries were prospectively surveyed on their implementation of SARS-CoV-2 disease (COVID-19) testing and infection control strategies. All participating departments (23) implemented standardised case definitions, testing guidelines, early triage
and infection control strategies early in the outbreak. Patient testing criteria initially focused on suspect cases and later began to include screening, mainly for hospital admissions. Long turnaround times for test results likely put additional strain on
healthcare resources. |
|
|
Kopar, PK, Brown, et al |
Ann Surg |
Healthcare Response | Réponse des soins de santé |
Our study aims to provide a paradigm when it is ethical to perform cardiopulmonary resuscitation (CPR) on patients
during the COVID-19 pandemic. Patients have the negative right to refuse care including CPR, but they do not have the positive right to demand it. Our detailed ethical analysis and recommendations support CPR if and only if 1) CPR is judged medically beneficial,
and in line with the patient's and values and goals, 2) allocations or scarce resources follow a just and transparent triage system, and 3) providers are protected from contracting the disease. |
|
|
Kriaucioniene, V, Bagdonaviciene, et al |
Nutrients |
Public Health response| Interventions de santé publique |
This study aimed to evaluate the effect of the quarantine on dietary, physical activity and alcohol consumption habits
of Lithuanians and the association between health behaviours and weight changes. Altogether 2447 subjects participated in the survey. Almost half of the respondents (49.4%) ate more than usual, 45.1% increased snacking, and 62.1% cooked at home more often.
Intake of carbonated or sugary drinks, fast food and commercial pastries decreased, while consumption of homemade pastries and fried food increased. A decrease in physical activity was reported by 60.6% of respondents. Every third (31.5%) respondent, more
often those already with overweight, gained weight. Multivariate logistic regression analysis showed that the higher odds of weight gain were associated with females, older age, increased consumption of sugary drinks, homemade pastries and fried food, eating
more than usual, increased snacking, decreased physical activity and increased alcohol consumption. |
|
|
Krieger, N, Waterman, et al |
Am J Public Health |
Epidemiology| Épidémiologie |
The aim of this study was to address evidence gaps in COVID-19 mortality inequities resulting from inadequate race/ethnicity
data and no socioeconomic data. We analyzed age-standardized death rates in Massachusetts by weekly time intervals, comparing rates for January 1 to May 19, 2020, with the corresponding historical average for 2015 to 2019 stratified by zip code social metrics.
At the surge peak (week 16, April 15-21), mortality rate ratios (comparing 2020 vs 2015-2019) were 2.2 (95% confidence interval CI] = 1.4, 3.5) and 2.7 (95% CI = 1.4, 5.5) for the lowest and highest zip code tabulation area (ZCTA) poverty categories, respectively,
with the 2020 peak mortality rate 1.1 (95% CI = 1.0, 1.3) times higher in the highest than the lowest poverty ZCTA. The COVID-19 mortality surge exhibited large inequities. |
|
|
PMC7550263; Neuroticism and Emotional Risk During the COVID-19 Pandemic |
Kroencke, L, Geukes, et al |
J Res Pers |
Public Health response| Interventions de santé publique |
This study sheds light on the role of the personality trait neuroticism in predicting who experiences negative affective
responses. In a large-scale experience-sampling study (N = 1,609; 38,120 momentary reports), we showed that individuals high in neuroticism experienced more negative affect and higher affective variability in their daily lives. Individuals high in neuroticism
also (a) paid more attention to COVID-19-related information and worried more about the consequences of the pandemic (crisis preoccupation), and (b) experienced more negative affect during this preoccupation (affective reactivity). These findings offer new
insights into the consequences and dynamics of neuroticism in extreme environmental contexts. |
|
Kutter, JasminS, de Meulder, et al |
bioRxiv |
Transmission Animal model | Modèle animal |
Here, a newly developed experimental set-up was used to study transmission of SARS-CoV and SARS-CoV-2 through the air
between ferrets over more than a meter distance. Both viruses caused a robust productive respiratory tract infection resulting in transmission of SARS-CoV-2 to two of four indirect recipient ferrets and SARS-CoV to all four. A control pandemic A/H1N1 influenza
virus also transmitted efficiently. Although the experiments did not discriminate between transmission via small aerosols, large droplets and fomites, these results demonstrate that SARS-CoV and SARS-CoV-2 can remain infectious while traveling through the
air. |
|
|
Labrague, LeodoroJ, De los Santos, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
The aime of this study was to determine the relative influence of coping behaviours, personal resilience, and social
support on student nurses’ emotional and social loneliness during the pandemic. cross-sectional research design was utilised to gather data from 261 student nurses from the Central Philippines using the Loneliness Scale, the Brief Resilience Scale, the Coping
Behaviour Questionnaire, and the Perceived Social Support Questionnaire through an online survey. The majority or 89.27% (n = 233) of student nurses experienced moderate to severe levels of loneliness during the lockdown. Loneliness among student nurses was
high during the height of the COVID-19 pandemic. |
|
|
Lai, T, Xiang, et al |
Virulence |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We conducted a prospective multi-center cross-sectional study to compare induced sputum to throat swabs for SARS-CoV-2
detection. Confirmed COVID-19 patients from six hospitals in six cities across China who received one or more negative RT-PCR result for SARS-CoV-2 were enrolled, and paired specimens (induced sputum and throat swabs; 56 cases) were assayed. In three paired
samples, both the induced sputum and throat swabs were positive for SARS-CoV-2. The positive rate for induced sputum was significantly higher than for throat swabs both overall (28.6% vs 5.4%, respectively; p < 0.01). Because induced sputum is more reliable
and has a lower false-negative rate than throat swabs, we believe induced sputum is more useful for the confirmation of COVID-19 and is safer as a criterion for release from quarantine. |
|
|
Lamure, S, Duléry, et al |
EClinicalMedicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective multicentric cohort study used the Programme de Médicalisation des Systèmes d'Information database
to identify all adult patients with lymphoma, hospitalized for Covid-19 in March and April 2020, in 12 hospitals of three French regions with pandemic outbreaks. The characteristics of lymphoma and Covid-19 were collected from medical charts. Eighty-nine patients
were included. With a median follow-up of 33 days from admission, 30-day overall survival was 71%, (95% confidence interval, 62-81%). In multivariable analysis, having an age ≥ 70 years (hazard ratio 2·87, 1·20-6·85, p = 0·02) and relapsed/refractory lymphoma
(hazard ratio 2·54, 1·14-5·66, p = 0·02) were associated with mortality. Thirty-day mortality was associated with being older and relapsed/refractory lymphoma. |
|
|
Mutational analysis and assessment of its impact on
proteins of SARS-CoV-2 genomes from India |
Laskar, Rezwanuzzaman, Ali, et al |
bioRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Herein the mutational status of 611 genomes from India along with their impact on proteins was ascertained. After excluding
gaps and ambiguous sequences, a total of 493 variable sites (152 parsimony informative and 341 singleton) were observed. The most prevalent reference nucleotide was C (209) and substituted one was T (293). Non-uniform geographical distribution of mutations
implied by Odisha (30 samples, 109 mutations) and Tamil Nadu (31 samples, 40 mutations) suggests that sequences in some regions are mutating faster than others. |
|
Lauridsen, MD, Butt, et al |
Int J Cardiol Heart Vasc |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to examine the association of Corona virus disease (COVID-19) pandemic and incidence of acute myocardial infarction
with cardiogenic shock (MI-CS). Using Danish nationwide registries, we identified patients hospitalized with MI-CS. Incidence rates (IR) and incidence rate ratios (IRR) were used to compare MI-CS before and after March 11 in 2015-2019 and in 2020. We identified
11,769 patients with MI of whom 696 (5.9%) had cardiogenic shock in 2015-2019. In 2020, 2,132 MI patients were identified of whom 119 had cardiogenic shock (5.6%). The IRRs comparing the 2020-period with the 2015-2019 period before and after March 11 (lockdown)
were 0.81 (95% CI: 0.59-1.12) and 0.87 (95% CI: 0.57-1.32), respectively. No difference in 7-day mortality or in-hospital management was observed between study periods. We could not identify a significant association of the national lockdown on the incidence
of MI-CS, along with similar in-hospital management and mortality in patients with MI-CS. |
|
|
Laxmipriya, S, Narayanan, et al |
Mater Today Proc |
Epidemiology| Épidémiologie |
In this study, we have attempted to establish a conceivable relationship between Covid 19 and PM10-2.5, obtained from
eleven airquality monitoring stations in Chennai city, India for both Pre and during Covid situations and its influence over Covid positive cases. he observations of the materials (+ve cases, PM 10, PM 2.5) collected proved that during precovid regime less
polluted areas are indicated with less than 5 infection cases reflecting the healthy people and they are less vulnerable to covid except the few occurrence of foreign source indicating no community spread whereus most polluted spots of precovid regimes are
indicated with more than 90 % cases and indicated that people in pollution zones are succumbed to get infected quickly. owever, during Covid the lockdown has considerably reduced the particulate suspension and the results revealed that the +ve cases are of
the nature of community spreading through primary and secondary contacts as reported from the media. |
|
|
Lee, SJ, Ward, et al |
Child Youth Serv Rev |
Public Health response| Interventions de santé publique |
This study reports on parent-child dynamics following COVID-19 related school closures, based on cross-sectional analyses
of a survey that utilized a convenience sampling approach. Data were collected approximately five weeks after the World Health Organization declared that the Coronavirus was a pandemic. Participants (N = 405) were adults recruited throughout the U.S. This
study examines data from parents (69% mothers and 31% fathers) with at least one child 0-12 years of age. Most (77.1%) reported use of online tools for at-home education, including educational apps, social media, and school-provided electronic resources. More
than one-third (34.7%) of parents said their child's behavior had changed since the pandemic, including being sad, depressed, and lonely. Multivariate analyses indicated that, compared to non-depressed parents, parents who met criteria for probable major or
severe depression (B = -.16, 95% CI = -.29, -.02], p = .021) and parenting stress (B = -.37, 95% CI = -.47, -.27], p < .001) were negatively associated with parents' perceived preparation to educate at home. Overall, study results suggested that parents' mental
health may be an important factor linked to at-home education and child wellbeing during the pandemic. |
|
|
Leng, L, Cao, et al |
Signal Transduct Target Ther |
Clinical data| Données cliniques Immunology | Immunologie |
To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,
fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia. After virus inactivation, a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.
We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism, blood coagulation, immune response, angiogenesis, and cell microenvironment regulation. Several inflammatory
factors were upregulated, which was possibly caused by the activation of NF-κB signaling. Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered. Our results systematically outlined the molecular pathological features
in terms of the lung response to SARS-CoV-2 infection, and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. |
|
|
León, Guillermo, Herrera, et al |
bioRxiv |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins Immunology
| Immunologie Animal model | Modèle animal |
Therefore, drawing upon decades of experience in manufacturing snake antivenom, we developed and preclinically evaluated
two anti-SARS-CoV-2 polyclonal equine formulations as potential alternative therapy for COVID-19. We immunized two groups of horses with either S1 (anti-S1) or a mixture of S1, N, and SEM mosaic (anti-Mix) viral recombinant proteins. Horses reached a maximum
anti-viral antibody level at 7 weeks following priming, and showed no major adverse acute or chronic clinical alterations. Two whole-IgG formulations were prepared via hyperimmune plasma precipitation with caprylic acid and then formulated for parenteral use.
Both preparations had similar physicochemical and microbiological quality and showed ELISA immunoreactivity towards S1 protein and the receptor binding domain (RBD). The anti-Mix formulation also presented immunoreactivity against N protein. Due to high anti-S1
and anti-RBD antibody content, final products exhibited high in vitro neutralizing capacity of SARS-CoV-2 infection, 80 times higher than a pool of human convalescent plasma. |
|
|
Levy, C, Basmaci, et al |
Pediatr Infect Dis J |
Epidemiology| Épidémiologie |
From March 2, 2020, to April 26, 2020, 52,588 reverse transcription polymerase chain reaction (RT-PCR) tests for severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were performed in France, 6490 in children and 46,098 in adults. The rate of RT-PCR-positive SARS-CoV-2 tests for children (5.9%) was always less than that for adults (20.3%) but vary according to the epidemic
stage. The risk ratio of RT-PCR-positive SARS-CoV-2 tests for adults compared with children was 3.5 (95% confidence interval: 3.2-3.9) for the whole study period. |
|
|
Li, DCY, Leung, et al |
Data Brief |
Public Health response| Interventions de santé publique |
Data on knowledge and fear of coronavirus disease 2019 (COVID-19) and perceived stress were collected in July 2020
from a convenience sample of Filipino domestic workers in Hong Kong by asking participants to take part in three questionnaires. The relationship between knowledge of COVID and fear of COVID was significant, r(108) = +0.23, p = .02; the relationship between
fear of COVID and perceived stress was not statistically significant, r(108) = +0.17, p = .08; the relationship between knowledge of COVID and perceived stress was not statistically significant, r(108) = -0.11, p = .26. Cronbach's alpha coefficients were obtained
for each of the three questionnaires to assess internal consistency reliability. |
|
|
Implications of Cardiac Markers in Risk-Stratification and Management for COVID-19
Patients |
Li, Pengping, Wu, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to discover a sensitive and reliable early-warning biomarker for optimizing management and improving
COVID-19 patients’ prognosis. This single-center case series was conducted between February 4 and April 10, 2020. In total, 2,954 consecutive COVID-19 patients who were receiving treatment at Wuhan Huoshenshan Hospital in China were included in the retrospectively
selected cohort. All patients were diagnosed with COVID-19 and treated at the study site. Among severe/critical COVID-19 patients, those with abnormal serum levels of brain natriuretic peptide had a significantly higher mortality rate than patients with normal
levels. Severe/critical COVID-19 patients with pre-existing CAD (165/1,155 [10.9%]) had more cases of abnormal brain natriuretic peptide levels than those without CAD. Enhanced SARS-CoV-2 receptor expression was observed in patients with CAD. Regression analysis
revealed that patients with elevated brain natriuretic peptide levels were at a higher risk of death (hazards ratio, 1.001 [95% confidence interval, 1.0003-1.002]). Brain natriuretic peptide is an effective biomarker for risk assessment in COVID-19 patients
with or without pre-existing CAD. |
|
Wuhan's experience in curbing the spread of coronavirus disease (COVID-19) |
Li, WY, Dai, et al |
Int Health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study explores the number of daily infection cases, hospitalization rate, lag time from onset to diagnosis date
and their associations with measures introduced to slow down the spread of COVID-19. This study recruited 6872 COVID-19 patients in the Wuchang district, Wuhan. All of the patients had an onset date from 21 December 2019 to 23 February 2020. The overall
hospitalization rate was 45.9% (95% CI 44.7 to 47.1%) and the mean lag time from onset to diagnosis was 11.1±7.4 d. The estimated infection curve was constructed for the period from 14 December 2019 to 23 February 2020. Early public awareness, early identification
and early quarantine, supported by appropriate infrastructure, are important elements for containing the spread of COVID-19 in the community. |
|
Li, X, Lin, et al |
Drug Dev Ind Pharm |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study aimed to explore the material basis and molecular mechanism of Shenfu Decoction through network pharmacology
and molecular mechanisms, to provide a research basis for clinical medication and clues for subsequent research. The active components and targets of Shenfu decoction were searched in the Traditional Chinese Medicine Systems Pharmacology Database and Analysis
Platform (TCMSP), and the COVID-19-associated genes were collected using the GeneCards platform. The Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment of the mapping targets were analyzed. According to the standard
of P < 0.05, GO function was enriched in 108 biological processes, 16 cell processes and 27 molecular processes. Sixty-three signaling pathways were enriched by KEGG, which can be divided into four types: viral infection pathways, signal pathways, biological
process pathways and different disease pathways. The comparison of negative and positive prescriptions further reflects the positive effect of Shenfu decoction against COVID-19. Shenfu decoction played an important role in regulating the anti-virus process,
regulating immunity, inhibiting inflammation and regulating apoptosis through the interrelated regulation mechanism of multi-components and multi-targets, to treat patients with severe COVID-19. |
|
|
Li, X, Marmar, et al |
Epidemiol Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To determine what exacerbate severity of the COVID-19 among patients without comorbidities and advanced age and investigate
potential clinical indicators for early |
|
|
Liao, JL, Chen, et al |
Int J Clin Pract |
Clinical data| Données cliniques |
This study aimed to investigate the distinctive CT characteristics of two stages of the disease (progression and remission).
We included all COVID-19 patients admitted to Wenzhou Central Hospital from January to February, 2020. Patients underwent multiple chest CT scans at intervals of 3-10 days. CT features were recorded, such as the lesion lobe, distribution characteristics (subpleural,
scattered, or diffused), shape of the lesion, maximum size of the lesion, lesion morphology (ground-glass opacity, GGO), and consolidation features. he ratios of some representative features differed between the remission stage and the progression phase, such
as round-shape lesion (8.0% vs. 34.4%), GGO (65.0% vs. 87.5%), consolidation (62.0% vs. 31.3%), large cable sign (59.0% vs. 9.4%), and crazy-paving sign (20.0% vs. 50.0%). The variables consolidation, boundary feature, large cable sign, and crazy-paving sign
were the most significant factors, based on a variable named 'prediction of progression or remission' (PPR) that we constructed. The ROC curve showed that PPR had an AUC of 0.882 (cutoff value = 0.66, sensitivity = 0.75, specificity = 0.875). CT characteristics,
in particular, round shape, GGO, consolidation, large cable sign, and crazy-paving sign, may increase the recognition of the intrapulmonary development of COVID-19. |
|
|
Liao, M, Yan, et al |
J Clin Lab Anal |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
Serological test for SARS-CoV-2 antibody can improve early diagnosis of COVID-19 and serves as a valuable supplement
to RNA detection. A SARS-CoV-2 IgG/IgM combined antibody test strip based on colloidal gold immunochromatography assay was developed, with both spike protein and nucleocapsid protein of SARS-CoV-2 antigen used for antibody detection. 158 out 170 samples from
confirmed COVID-19 patients had positive results from the test, and 296 out of 300 samples from normal controls had negative results. The kit was 92.9% sensitive and 98.7% specific. The positive rate was 77.3% during the first week after disease onset, but
reached 100% since day 9. AUC and kappa coefficient were 0.958 and 0.926, respectively, which showed the consistency of the test results with the standard diagnosis. he rapid, easy-to-use SARS-CoV-2 IgG/IgM combined antibody test kit has a superior performance,
which can help with accurate diagnosis and thus timely treatment and isolation of COVID-19 patients, that contributes to the better control of the global pandemic. |
|
|
Lima-Costa, M, Macinko, et al |
Cad Saude Publica |
Public Health response| Interventions de santé publique |
We developed the ELSI-COVID-19 telephone interview initiative, to briefly describe this initiative methodology and
examine its external validity regarding sociodemographic characteristics. The study used a probability complex sampling clustered in strata, combining municipalities, census tracts, and households. The final sample included 70 municipalities in all five major
geographic regions of the country. All individuals who participated in the second wave were eligible for telephone interview. Survey weights for analyzing telephone interview data were specifically calculated for participants who answered the survey, considering
their age, gender, and education level. Of the 9,177 eligible ELSI-Brazil participants, 6,149 (67%) participated in the telephone survey. This article presents this initiative methodology and some sociodemographic characteristics of the 6,149 participants
in the survey first round, relative the Brazilian population within the same age group. |
|
|
Lima-Costa, M, Mambrini, et al |
Cad Saude Publica |
Public Health response| Interventions de santé publique |
The aim of the study was to examine the prevalence of social distancing, the use of face masks and hand washing when
leaving home among Brazilian adults aged 50 or over. Data from 6,149 telephone interviews were used, conducted between May 26 and June 8, 2020 among participants in the Brazilian Longitudinal Study of Aging (ELSI-Brazil). Social distancing was defined by not
having left home in the last seven days. Only 32.8% of study participants did not leave home during the period considered, 36.3% left between one and two times, 15.2% between three and five times and 15.7% left every day. The main reasons for leaving home
were to buy medicine or food (74.2%), to work (25.1%), to pay bills (24.5%), for health care (10.5%), to exercise (6.2%), and to meet family or friends (8.8%). Among those who left home, 97.3% always wore face masks and 97.3% always performed hand washing.
Women left home less often than men. Men left home more often to work and exercise while women left home more often to seek healthcare. Men (odds ratio - OR = 1.84), those with higher education (OR = 1.48 and 1.95 for 5-8 and 9 years, respectively) and urban
residents (OR = 1.54) left home more frequently to perform essential activities, regardless of age or other characteristics. Results show low adherence to social distancing, but high prevalence in the reported use of face masks and hand washing. |
|
|
The Architecture of Inactivated SARS-CoV-2 with Postfusion Spikes Revealed by Cryo-EM
and Cryo-ET |
Liu, C, Mendonça, et al |
Structure |
Coronavirology| Coronavirologie |
We have genetically and structurally characterized β-propiolactone-inactivated viruses from a propagated and purified
clinical strain of SARS-CoV-2. We observed that the virus particles are roughly spherical or moderately pleiomorphic. Although a small fraction of prefusion spikes are found, most spikes appear nail shaped, thus resembling a postfusion state, where the S1
protein of the spike has disassociated from S2. Cryoelectron tomography and subtomogram averaging of these spikes yielded a density map that closely matches the overall structure of the SARS-CoV postfusion spike and its corresponding glycosylation site. Our
findings have major implications for SARS-CoV-2 vaccine design, especially those using inactivated viruses. |
|
Liu, H, Luo, et al |
Infect Dis Ther |
Clinical data| Données cliniques |
The evolution of computed tomography (CT) findings in patients with mild coronavirus disease 2019 (COVID-19) pneumonia
has not been described in detail. We analyzed 606 CT scans of 182 patients. The dynamic evolution of CT scores was evaluated using two staging methods: one was divided into 10 periods based on decile intervals, and the other was one stage per week. In the
dynamic evolution of 10 stages, the total lesion CT score peaked during stage 3 (9-11 days) and stage 6 (17-18 days), with scores = 7.19 ± 3.66 and 8.00 ± 4.57, respectively. The consolidation score peaked during stage 6 (17-18 days; score = 2.72 ± 3.07).
In contrast, when a 1-week interval was used and time was divided into five stages, the total lesion score peaked during week 3 (score = 7.3 ± 4.15). The consolidation score peaked during week 2 (score = 2.54 ± 3.25). The total lesion score of mild COVID-19
pneumonia peaked 17-18 days after disease onset. The consolidation scores objectively reflected the severity of the lung involvement compared with total lesion scores. Each temporal stage of mild COVID-19 pneumonia mainly manifested as GGO pattern. |
|
|
Liu, Hongwei, Plancarte, et al |
bioRxiv |
Clinical data| Données cliniques Animal model | Modèle animal |
To understand susceptibility of California sea lions and Northern elephant seals to influenza A virus (IAV), we developed
an ex vivo respiratory explant model and used it to compare infection kinetics for multiple IAV subtypes. We used a similar approach with explants from rhesus macaques to establish the system and to compare infection kinetics with marine mammals. Trachea,
bronchi, and lungs from 11 California sea lions, 2 Northern elephant seals and 10 rhesus macaques were inoculated within 24 hours post-mortem with 6 strains representing 4 IAV subtypes. Immunohistochemistry localized IAV infection to apical epithelial cells.
These results demonstrate that respiratory tissue explants from marine mammals support IAV infection. We adapted the explant approach and used it to inoculate tissues from 2 rhesus macaques with severe acute respiratory syndrome virus 2 (SARS-CoV-2). SARS-CoV-2
titers increased by 2-4 log10 PFU/explant relative to the inoculum and peaked 48 or 72 hpi in trachea, bronchi, and kidney of both macaques and in the lung of 1 animal. These results demonstrate that this ex vivo model can define infection dynamics for 2 respiratory
viruses of significant public health importance. |
|
|
Liu, P, Zhang, et al |
Clin Respir J |
Healthcare Response | Réponse des soins de santé |
This paper describes the layout and functioning of a typical Fangcang shelter hospital, Wuhan Dongxihu Fangcang shelter
Hospital, where the author has worked, the working mechanism, experience and effectiveness. A set of patient management protocols was employed for daily practice, which included pre-set criteria and procedure for admission, examination, medication treatment,
referral and discharge. WeChat platform with different groups was used for communication, ward round, test appointments and patient data communication. As a result, 442 mild or moderate Covid-19 patients in Hall C were successfully managed by a team of 40
doctors, with 246 (56%) patients were cured and discharged from the Fangcang shelter hospital while the remaining 196 (44%) patients were referred on to designated hospitals for further treatment. In summary, the Fangcang shelter hospital could be run successfully
with a set of patient management protocols under conditions of limited facilities and medical staff. It was effective and safe in isolating patients, providing basic medical care and early identification of potential severe cases. |
|
|
Liu, PY, Tsai, et al |
J Med Internet Res |
Healthcare Response | Réponse des soins de santé |
The aim of this paper is to demonstrate how the National Cheng Kung University Hospital artificial intelligence (AI)
trilogy of diversion to a smart quarantine station, AI-assisted image interpretation, and a built-in clinical decision-making algorithm improves medical care and reduces quarantine processing times. This observational study on the emerging COVID-19 pandemic
included 643 patients. An "AI trilogy" of diversion to a smart quarantine station, AI-assisted image interpretation, and a built-in clinical decision-making algorithm on a tablet computer was applied to shorten the quarantine survey process and reduce processing
time during the COVID-19 pandemic. Compared with the conventional ED (n=281), the survey time at the quarantine station (n=1520) was significantly shortened; the median survey time at the ED was 153 minutes (95% CI 108.5-205.0), vs 35 minutes at the quarantine
station (95% CI 24-56; P<.001). Furthermore, the median survey time without AI was 101 minutes (95% CI 40-153), vs 34 minutes (95% CI 24-53) with AI in the quarantine station (P<.001). The AI trilogy improved our medical care workflow by shortening the quarantine
survey process and reducing the processing time, which is especially important during an emerging infectious disease epidemic. |
|
|
Liu, S, Qin, et al |
Int J Environ Res Public Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This paper analyzed case information for 417 patients with COVID-19 in Shenzhen, China. The nearest neighbor index
method, kernel density method, and the standard deviation ellipse method were used to analyze the spatio-temporal characteristics of the COVID-19 spread in Shenzhen. The results show that: (1) The development of COVID-19 epidemic situation in Shenzhen occurred
in three stages. The patients showed significant hysteresis from the onset of symptoms to hospitalization and then to diagnosis. Prior to 27 January, there was a relatively long time interval between the onset of symptoms and hospitalization for COVID-19;
the interval decreased thereafter. (2) The epidemic site (the place where the patient stays during the onset of the disease) showed an agglomeration in space. The degree of agglomeration constantly increased across the three time nodes of 31 January, 14 February,
and 22 February. The epidemic sites formed a "core area" in terms of spatial distribution and spread along the "northwest-southeast" direction of the city. (3) Economic and social factors significantly impacted the spread of COVID-19, while environmental factors
have not played a significant role. |
|
|
Liu, YL, Ren, et al |
Ann Surg |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Aim of this study is to describe the epidemiologic features and clinical courses of gastrointestinal cancer patients
with pre/asymptomatic COVID-19 and to explore evidence of SARS-CoV-2 in the surgically resected specimens. Clinical data were retrospectively collected and analyzed. Surgically resected specimens of the cases with confirmed COVID-19 were obtained to detect
the expression of ACE2 and the presence of SARS-CoV-2. total of 52 patients (male, 34) with a median age 62.5 years were enrolled. All were identified to be preoperatively pre/asymptomatic, as 5 were with SARS-CoV-2 presenting in cytoplasm of enterocytes or
macrophages from the colorectal tissues and 1 had symptom onset immediately after surgery. The case fatality rate in patients with COVID-19 was 16.7%, much higher than those without COVID-19 (2.2%). Gastrointestinal cancer patients with pre/asymptomatic COVID-19
were at high risk of postoperative onset and death. |
|
|
Near-real-time monitoring of global CO(2) emissions reveals the effects of the
COVID-19 pandemic |
Liu, Z, Ciais, et al |
Nat Commun |
Public health interventions*| Interventions de santé publique |
The COVID-19 pandemic is impacting human activities, and in turn energy use and carbon dioxide (CO(2)) emissions. Here
we present daily estimates of country-level CO(2) emissions for different sectors based on near-real-time activity data. The key result is an abrupt 8.8% decrease in global CO(2) emissions (-1551 Mt CO(2)) in the first half of 2020 compared to the same period
in 2019. The magnitude of this decrease is larger than during previous economic downturns or World War II. The timing of emissions decreases corresponds to lockdown measures in each country. By July 1st, the pandemic's effects on global emissions diminished
as lockdown restrictions relaxed and some economic activities restarted, especially in China and several European countries, but substantial differences persist between countries, with continuing emission declines in the U.S. where coronavirus cases are still
increasing substantially. |
|
PMC7546183; Incidence of heparin-induced thrombocytopenia in patients with 2019
coronavirus disease |
Lozano, R, Franco, et al |
Med Clin (Engl Ed) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study we have retrospectively analysed a cohort of COVID-19 patients (diagnosed by the polymerase chain reaction
test or PCR), under prophylactic treatment with LMWH (bemiparin 2,500−3,500 IU Anti-Xa). They were consecutively admitted to the Hospital Real de Nuestra Señora de Gracia, internal medicine department, between 1 st February and 16th March 2020, with a platelet
count every 3−5 days and baseline between 100 and 500 × 103/ mm3. The final study sample was 43 patients of which 42% were being treated with hydroxychloroquine and 35% with hydroxychloroquine and lopinavir + ritonavir; 17 had associated risk factors: 35%
DM2, 64.7% arterial hypertension and 17.6% renal failure. The results identified 3 patients (6.9% of the sample), all male and aged 45, 71 and 90 years, whose risk quantification of iatrogenic thrombocytopaenia obtained a value of 6, according to the 4 Ts
scoring system.2 This meant they had a high probability of presenting HIT (Table 1). The incidence of HIT observed in our cohort (6.9%), although of moderate intensity (minimum platelet count reached > 100), seems to suggest, as described by Xuan et al.,3
that prior exposure to heparin is not absolutely necessary to induce HIT in COVID-19 patients, and that HIT can occur spontaneously as a result of SARS-CoV-2 infection. |
|
Nucleic acid and antibody assay results in Chinese patients with coronavirus
disease 2019 (COVID-19) |
Lu, Y, Li, et al |
Int Immunopharmacol |
Clinical data| Données cliniques Immunology | Immunologie |
The aim of this study is to evaluate the nucleic acid and antibody test results of patients with Coronavirus Disease
2019 (COVID-19) in China. All patients with laboratory-confirmed SARS-CoV-2 infection from Jan to Apr 2020 were retrospectively analyzed. Clinical characteristics and laboratory test results were obtained from electronic medical records. Most individuals had
mild symptoms, and no patient died during treatment. All patients were tested positive for SARS-CoV-2 in sputum and nasopharyngeal samples, and 40 (54.8%) were also tested positive in stool. Nine(12.3%) patients were re-positive for SARS-CoV-2, as assessed
by Reverse Transcription-Polymerase Chain Reaction (RT-PCR) after discharge. Sixty-five (89.0%) patients had IgM or IgG antibodies against SARS-CoV-2.Among the four age groups, there was no difference in IgG antibody production (P = 0.664).CD3, CD4, CD8 and
CD19 cell counts between the antibody producing and non-producing groups showed no significant differences (all P > 0.05).The antibodies disappeared within two months in four patients. Patients after recovery from COVID-19 can be tested positive for SARS-CoV-2.Some
patients may produce antibodies only for a short time, or even no antibodies at all. |
|
Lynch, Christopher, Gore, et al |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study explores the effectiveness of forecasting methods during early onset for COVID-19 case counts over the upcoming
seven-days at the county, health district, and state levels. We apply forecasting methods across VA’s counties and independent cities, its health districts, and the state using data reported by the The New York Times. We forecast one-, three-, and seven-days
forward using: (1) a naïve approach; (2) Holt-Winters exponential smoothing (HW); (3) growth rate (Growth); (4) moving average (MA); (5) autoregressive (AR); (6) autoregressive moving average (ARMA); and (7) autoregressive integrated moving average (ARIMA).
Single-day MA forecast with three-day lookback obtains the lowest MdAE and is statistically significantly different than 66 percent of evaluated alternatives at each geographic level. Furthermore, methods assuming stationary means of prior days’ case counts
outperform methods with assumptions of weak- or non-stationarity. Finally, for an individual forecasting method, MdAPE evaluation reveals in most cases statistically significant differences across geographic levels demonstrating that there is not a one-size-fits-all
solution to short-term COVID-19 forecasting. |
|
|
Ma, Y, Liu, et al |
Am J Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Objective is to compare the epidemic prevention ability of COVID-19 of each province in China and to evaluate the existing
prevention and control capacity of each province. We established a quasi-Poisson linear mixed-effects model using the case data in cities outside Wuhan in Hubei Province, China. We adapted this model to estimate the number of potential cases in Wuhan and obtained
epidemiological parameters. The estimated potential cases in Wuhan were about 3 times the reported cases. The basic reproductive number was 3.30 during the initial outbreak. Provinces with more estimated imported cases than reported cases were those in the
surrounding provinces of Hubei, including Henan and Shaanxi. The regions where the number of reported cases was closer to the predicted value were most the developed areas, including Beijing and Shanghai.The number of confirmed cases in Wuhan was underestimated
in the initial period of the outbreak. Provincial surveillance and emergency response capabilities vary across the country. |
|
|
Macinko, J, Woolley, et al |
Cad Saude Publica |
Public Health response| Interventions de santé publique |
The study examines the prevalence of COVID-19 related symptoms, care-seeking, and cancellation of surgery or other
scheduled medical care among a nationally representative sample of Brazilians aged 50 and over derived from the Brazilian Longitudinal Study of Aging (ELSI-Brazil) and a telephone follow-up survey (the ELSI-COVID-19 initiative) between late May and early June
2020. About 10.4% of older adults reported any fever, dry cough or difficulty breathing in the 30 days prior to the interview, with the highest prevalence in the North region (50%). Among individuals with symptoms, only 33.6% sought care. Individuals living
in the South or Southeast regions were significantly less likely to seek care for COVID-19 related symptoms. Nearly one in six participants had to cancel scheduled surgery or other medical care; this proportion was higher among women, those with more education,
and people with multiple chronic conditions. |
|
|
Maclean, W, Limb, et al |
Colorectal Dis |
Healthcare Response | Réponse des soins de santé |
We describe a major reorganisation of service at a regional referral centre (Royal Surrey NHS Foundation Trust) to
manage the crisis. Faecal immunochemical testing (FIT) was implemented for triage to make optimum use of limited diagnostic resources. Consultations were switched from face‐to‐face to telephone. We aimed to evaluate the impact FIT had on resource allocation
and patient diagnoses in the first three months of use. From 26th March 2020 to 2nd July there were 381 referrals who were invited to provide FIT samples and underwent telephone consultations. 358 FIT samples were returned (94%). Onward referral for colonoscopy
reduced from 62% to 34% (p<0.001). There were fourteen colorectal cancers (3.7%) diagnosed, which was not statistically different to the pre‐pandemic level of 3.9% (p=0.995). Twelve of fourteen patients with colorectal cancer diagnoses had provided samples
and all twelve had FIT ≥10 μg/g and were offered fast‐track investigations. Incorporation of FIT optimised the allocation of limited resources to triage those that required urgent colonic investigation in detecting colorectal cancer. |
|
|
Low mortality of hospitalised patients with COVID-19 in a tertiary Danish hospital
setting |
Madsen, LW, Lindvig, et al |
Int J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to describe clinical characteristics and outcomes of admitted COVID-19 patients in a Danish hospital setting
where an early active government intervention was taken. Prospective cohort study including all admitted patients to the COVID-19 unit at Odense University Hospital from March 10 to April 21, 2020. We included 83 patients (median age 62 years, 62.7% male).
In total, ARDS was diagnosed in 33.7% (28/83) of the patients corresponding to an incidence rate of 7.1 per 100 person days (95% CI: 4.1-10.2). Overall 13 patients (15.7%) were transferred to the ICU of whom 11 (84.6%) received corticosteroids. Despite similar
patient characteristics compared to those reported by others, we found a low overall mortality of < 5%. |
|
Magro, C, Mulvey, et al |
Hum Pathol |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
The purpose of this study was to examine the deltoid skin biopsy in twenty-three COVID-19 patients, most severely ill,
for vascular complement deposition and correlate this with SARS CoV-2 viral RNA and protein localization and ACE2 expression. In 21/23 cases, substantial microvascular deposition of complement components was identified. Microvascular complement deposition
strongly co-localized in situ with the SARS CoV-2 viral proteins including spike glycoproteins in the endothelial cells as well as the viral receptor ACE2 in lesional and non-lesional skin; viral RNA was not evident. Microvascular SARS CoV-2 viral protein,
complement and ACE2 expression was most conspicuous in the subcutaneous fat. Although the samples from severely ill patients with COVID-19 were from grossly normal skin, light microscopically focal microvascular abnormalities were evident that included endothelial
cell denudement, basement membrane zone reduplication and small thrombi. It is concluded that complement activation is common in grossly normal skin, primarily in the subcutaneous fat which may provide a link between severe disease and obesity, in people with
severe COVID-19 and the strong co-localization with the ACE2 receptor and viral capsid proteins without viral RNA suggests that circulating viral proteins (i.e. pseudovirions) may dock onto the endothelial of these microvessels and induce complement activation. |
|
|
Usefulness of Elevated Troponin to Predict Death in Patients with COVID-19 and
Myocardial Injury |
Majure, DT, Gruberg, et al |
Am J Cardiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We sought to determine the association of elevated troponin with mortality in a large, ethnically diverse population
of patients hospitalized with COVID-19, and to determine the association of elevated inflammatory markers with increased troponin levels. We reviewed all patients admitted at our health system with COVID-19 from March 1 to April 27, 2020, who had a troponin
assessment within 48 hours of admission. We used logistic regression to calculate odds ratios (ORs) for mortality during hospitalization, controlling for demographics, comorbidities, and markers of inflammation. Of 11159 patients hospitalized with COVID-19,
6247 had a troponin assessment within 48 hours. Patients with elevated troponin had significantly increased odds of death for mildly elevated compared to normal troponin (adjusted OR, 2.06; 95% CI, 1.68-2.53; P < .001) and for severely elevated compared to
normal troponin (OR, 4.51; 95% CI, 3.66-5.54; P < .001) independently of elevation in inflammatory markers. In conclusion, patients hospitalized with COVID-19 and elevated troponin had markedly increased mortality compared to patients with normal troponin
levels. |
|
Individuals with Down syndrome hospitalized with COVID-19 have more severe
disease |
Malle, L, Gao, et al |
Genet Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We report an analysis of individuals with Down syndrome (DS) who were hospitalized with COVID-19 in New York, New York,
USA. In this retrospective, dual-center study of 7246 patients hospitalized with COVID-19, we analyzed all patients with DS admitted in the Mount Sinai Health System and Columbia University Irving Medical Center. We assessed hospitalization rates, clinical
characteristics, and outcomes. We identified 12 patients with DS. Hospitalized individuals with DS are on average ten years younger than patients without DS. Patients with DS have more severe disease than controls, particularly an increased incidence of sepsis
and mechanical ventilation. We demonstrate that individuals with DS who are hospitalized with COVID-19 are younger than their non-DS counterparts, and that they have more severe disease than age-matched controls. We conclude that particular care should be
considered for both the prevention and treatment of COVID-19 in these patients. |
|
Parenting-Related Exhaustion During the
Italian COVID-19 Lockdown |
Marchetti, D, Fontanesi, et al |
J Pediatr Psychol |
Public Health response| Interventions de santé publique |
The aim of the study was to examine the prevalence of parenting-related exhaustion-and to identify its associated risk
and protective factors-4 weeks into the lockdown in Italy. A total of 1,226 parents provided their consent to participate in the study and completed a web-based survey that included demographic questions, information relating to particular COVID-19 experiences,
and measures of emotional exhaustion, parental resilience, social connections, and psychological distress during the lockdown. Seventeen percent of our sample experienced significant parenting-related exhaustion, with mothers more severely affected. Multiple
regression analyses showed that greater parenting-related exhaustion was predicted by psychological distress, lower parental resilience, motherhood, fewer perceived social connections, and being single, as well as having a child with special needs, having
a large number of children, and having younger children. The findings add further support to the call for preventive programs to support parents throughout the COVID-19 pandemic. |
|
Marquès, M, Rovira, et al |
Environ Res |
Epidemiology| Épidémiologie |
In the present preliminary case-study conducted in Tarragona Province (Catalonia, Spain), we studied the potential
association of COVID-19 with PM(10), NO(2) and O(3), as well as the differences in the incidence and lethality of this disease. This Province is divided into two "health regions": Camp de Tarragona, with an important industrial complex, and Terres de l'Ebre,
with a great agricultural component. In spite of the notable limitations of the current study, our preliminary findings indicate that the industrialized/urban areas of Tarragona Province show a higher incidence and mortality of COVID-19 than the agricultural/rural
zones. These -and previous-results would highlight the importance of conducting specific investigations focused on directly assessing whether air pollutants such as particulate matter can act as carriers of the SARS-CoV-2. If confirmed, the recommendation
on keeping the "social distance" (1.5-2 m) might need to be adapted to this situation. |
|
|
Martin, J, Klapsa, et al |
Viruses |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
We have investigated the presence of SARS-CoV-2 RNA in wastewater samples from South-East England between 14th January
and 12th May 2020. A novel nested RT-PCR approach targeting five different regions of the viral genome improved the sensitivity of RT-qPCR assays and generated nucleotide sequences at sites with known sequence polymorphisms among SARS-CoV-2 isolates. We were
able to detect co-circulating virus variants, some specifically prevalent in England, and to identify changes in viral RNA sequences with time consistent with the recently reported increasing global dominance of Spike protein G614 pandemic variant. Low levels
of viral RNA were detected in a sample from 11th February, 3 days before the first case was reported in the sewage plant catchment area. SARS-CoV-2 RNA concentration increased in March and April, and a sharp reduction was observed in May, showing the effects
of lockdown measures. We conclude that viral RNA sequences found in sewage closely resemble those from clinical samples and that environmental surveillance can be used to monitor SARS-CoV-2 transmission, tracing virus variants and detecting virus importations. |
|
|
Martinho, FC, Griffin, et al |
J Endod |
Healthcare Response | Réponse des soins de santé |
This survey investigated the effect of the COVID-19 pandemic on the clinical practice of endodontics among the AAE
members by evaluating the impact on clinical activities, patient screening, infection control measurements, potential transmission, clinical protocols as well as psychological concerns. A descriptive, cross-sectional survey was developed to query AAE members
from all seven districts. The survey consisted of 24 questions, eight demographic questions, and 16 questions related to the COVID-19 pandemic impact on the clinical practice. A total of 454 AAE members participated in the survey. As of July 2020, most endodontists
were active in front line treatment of dental patients (82%). N95 respirator face mask was described by 83.1% of the participants as special measures beyond the regular PPE. Rubber dam isolation was recognized by the majority of the participants at some level
to reduce the chance of COVID-19 cross-infection. Most of the endodontist participants acknowledged trauma followed by swelling, pain, postoperative complication to be emergencies. The majority of respondents reported being concerned about the effect of COVID-19
upon their practice. No differences in worries about COVID-19 infection were related to demographics (p>.05). The majority of the Endodontists are aware of the COVID-19 pandemic, taking special precautions, and are concerned about contracting and spreading
the virus. |
|
|
Food choice motives and the nutritional quality
of diet during the COVID-19 lockdown in France |
Marty, L, de Lauzon-Guillain, et al |
Appetite |
Public Health response| Interventions de santé publique |
We examined how changes in food choice motives related to changes in nutritional quality during the lockdown compared
to before. A convenience sample of 938 French adults completed online questionnaires on the Qualtrics platform at the end of April 2020. Participants were retrospectively asked about their food choice motives and food consumption during the month before and
in the first month of the lockdown. The importance of nine food choice motives was assessed: health, convenience, sensory appeal, natural content, ethical concern, weight control, mood, familiarity, and price, scoring from 1 to 4. Food intakes were recorded
using a food frequency questionnaire including 110 foods, 12 non-alcoholic beverages and 4 alcoholic beverages. Adherence to the French dietary recommendations before and during the lockdown was estimated using the simplified PNNS-GS2 score, scoring from -17
to 11.5. The nutritional quality of diet was lower during the lockdown compared to before (-0.32, SD 2.28, p<0.001). Food choice motives significantly changed and an increase in the importance of weight control was associated with increased nutritional quality
(β=0.89, p<0.001, partial η(2)=0.032), whereas an increase in the importance of mood was associated with decreased nutritional quality (β=-0.43, p=0.021, partial η(2)=0.006). The lockdown period in France was related to a decrease in nutritional quality of
diet on average, which could be partly explained by changes in food choice motives. |
|
Death Rate Due to COVID-19 in Alzheimer's Disease
and Frontotemporal Dementia |
Matias-Guiu, J, Pytel, et al |
J Alzheimers Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to evaluate the frequency and mortality of COVID-19 in patients with Alzheimer's disease (AD) and frontotemporal
dementia (FTD). We conducted an observational case series. We enrolled 204 patients, 15.2% of whom were diagnosed with COVID-19, and 41.9% of patients with the infection died. Patients with AD were older than patients with FTD (80.36±8.77 versus 72.00±8.35
years old) and had a higher prevalence of arterial hypertension (55.8% versus 26.3%). COVID-19 occurred in 7.3% of patients living at home, but 72.0% of those living at care homes. Living in care facilities and diagnosis of AD were independently associated
with a higher probability of death. We found that living in care homes is the most relevant factor for an increased risk of COVID-19 infection and death, with AD patients exhibiting a higher risk than those with FTD. |
|
Antiviral activity of traditional medicinal plants from
Ayurveda against SARS-CoV-2 infection |
Maurya, VK, Kumar, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study was planned to investigate the antiviral role of the active constituents against spike glycoprotein of SARS-CoV-2
as well as its host ACE2 receptor. Structure-based drug design approach has been used to elucidate the antiviral activity of active constituents present in traditional medicinal plants from Ayurveda. Further, parameters like drug-likeness, pharmacokinetics,
and toxicity were determined to ensure the safety and efficacy of active constituents. Gene network analysis was performed to investigate the pathways altered during COVID-19. The prediction of drug-target interactions was performed to discover novel targets
for active constituents. The results suggested that amarogentin, eufoliatorin, α-amyrin, caesalpinins, kutkin, β-sitosterol, and belladonnine are the top-ranked molecules have the highest affinity towards both the spike glycoprotein and ACE2. Most active constituents
have passed the criteria of drug-likeness and demonstrated good pharmacokinetic profile with minimum predicted toxicity level. Gene network analysis confirmed that G-protein coupled receptor, protein kinase B signaling, protein secretion, peptidyl-serine phosphorylation,
nuclear transport, apoptotic pathway, tumor necrosis factor, regulation of angiotensin level, positive regulation of ion transport, and membrane protein proteolysis were altered during COVID-19. The target prediction analysis revealed that most active constituents
target the same pathways which are found to be altered during COVID-19. Collectively, our data encourages the use of active constituents as a potential therapy for COVID-19. |
|
Mavrodiev, EvgenyV, Tursky, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Coronaviruses are highly pathogenic and therefore important human and veterinary pathogens viruses worldwide. Members
of family Coronaviridae have previously been analysed phylogenetically, resulting in proposals of virus interrelationships. However, available Coronavirus phylogenies remain unrooted, based on limited sampling, and normally depend on a single method. The main
subjects of this study are the taxonomy and systematics of coronaviruses and our goal is to build the first natural classification of Coronaviridae using several methods of cladistic analyses, Maximum Likelihood method, as well as rigorous taxonomic sampling,
making the most accurate representation of Coronaviridae s relationships to date. Nomenclature recommendations to help effectively incorporate principles of binary nomenclature into Coronaviridae taxonomy are provided. We have stressed that no member of Sarbecovirus
clade is an ancestor of SARS Cov 2, and humans are the only known host.Competing Interest StatementThe authors have declared no competing interest. |
|
|
Mayasari, NR, Ho, et al |
Nutrients |
Public Health response| Interventions de santé publique |
Limited data are available on how this pandemic is affecting our dietary and lifestyle-related behaviors at the global
level. Google Trends was used to obtain worldwide relative search volumes (RSVs) covering a timeframe from before the COVID-19 pandemic 1 June 2019 to 27 April 2020. Spearman's rank-order correlation coefficients were used to measure relationships between
daily confirmed cases and aforementioned RSVs between 31 December 2019 and 15 April 2020. RSV curves showed increased interest in multiple keywords related to dietary and lifestyle behaviors during the COVID-19 lockdown period in March and April 2020. Spearman's
correlation analysis showed that the strongest variables in each keyword category were food security (food shortage, food bank, free food); dietary behaviours (delivery, restaurant, take-away, food delivery); outdoor-related behaviours (resort, hotel, cinema,
park, fitness, gym, plant, sunbathing, and online); immune-related nutrients/herbs/foods (vitamin C, vitamin A, zinc, immune, vitamin E, garlic, omega-3 fatty acid, vitamin D, and tumeric). Restricted movement has affected peoples' dietary and lifestyle behaviors
as people tend to search for immune-boosting nutrients/herbs and have replaced outdoor activities with sedentary indoor behaviors. |
|
|
Stereotactic
Body Radiotherapy Versus Delayed Surgery for Early-stage Non-small-cell Lung Cancer |
Mayne, NR, Lin, et al |
Ann Surg |
Healthcare Response | Réponse des soins de santé |
The objective was to evaluate the overall survival of patients with operable stage IA non-small-cell lung cancer (NSCLC)
who undergo "early" SBRT (within 0-30 days after diagnosis) versus "delayed" surgery (90-120 days after diagnosis). Multivariable Cox proportional hazards modeling and propensity score-matched analysis was used to compare the overall survival of patients with
stage IA NSCLC in the National Cancer Data Base from 2004 to 2015 who underwent "early" SBRT (0-30 days after diagnosis) versus that of patients who underwent "delayed" wedge resection (90-120 days after diagnosis).During the study period, 570 (55%) patients
underwent early SBRT and 475 (45%) underwent delayed wedge resection. In multivariable analysis, delayed resection was associated with improved survival adjusted hazard ratio 0.61; 95% confidence interval (CI): 0.50-0.76]. Propensity-score matching was used
to create 2 groups of 279 patients each who received early SBRT or delayed resection that were well-matched with regard to baseline characteristics. The 5-year survival associated with delayed resection was 53% (95% CI: 45%-61%) which was better than the 5-year
survival associated with early SBRT (31% 95% CI: 24%-37%]). In this national analysis, for patients with stage IA NSCLC, extended delay of surgery was associated with improved survival when compared to early treatment with SBRT. |
|
McCloskey, EV, Harvey, et al |
Osteoporos Int |
Healthcare Response | Réponse des soins de santé |
We have quantified the global impact by examining changes in the usage of online FRAX fracture risk assessments before
and after the declaration of the pandemic (11 March 2020). The study comprised a retrospective analysis using GoogleAnalytics data on daily sessions on the FRAX® website ( www.sheffield.ac.uk/FRAX ) from November 2019 to April 2020 (main analysis period February-April
2020), and the geographical source of that activity. Over February-April 2020, the FRAX website recorded 460,495 sessions from 184 countries, with 210,656 sessions in February alone. In March and April, the number of sessions fell by 23.1% and 58.3% respectively,
a pattern not observed over the same period in 2019. There were smaller reductions in Asia than elsewhere, partly related to earlier and less-marked nadirs in some countries (China, Taiwan, Hong Kong, South Korea and Vietnam). In Europe, the majority of countries
(24/31, 77.4%) reduced usage by at least 50% in April. Seven countries showed smaller reductions (range - 2.85 to - 44.1%) including Poland, Slovakia, Czech Republic, Germany, Norway, Sweden and Finland. There was no significant relationship between the reduction
in FRAX usage and measures of disease burden such as COVID-attributed deaths per million of the population. This study documents a marked global impact of the COVID-19 pandemic on the management of osteoporosis as reflected by FRAX online fracture risk assessments. |
|
|
Presence and Duration
of Symptoms in Febrile Infants With and Without SARS-CoV-2 Infection |
McLaren, SH, Dayan, et al |
Pediatr Infect Dis J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The clinical course of SARS-CoV-2 infection in young infants is not well understood. In this prospective cohort study,
we compared the presence and duration of symptoms in febrile infants ≤60 days with (n = 7) and without (n = 16) SARS-CoV-2 infection. Overall, we observed overlapping symptoms and duration of illness, with longer length of cough and nasal congestion among
the SARS-CoV-2-positive infants. |
|
Presence and Duration
of Symptoms in Febrile Infants With and Without SARS-CoV-2 Infection |
McLaren, SH, Dayan, et al |
Pediatr Infect Dis J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The clinical course of SARS-CoV-2 infection in young infants is not well understood. In this prospective cohort study,
we compared the presence and duration of symptoms in febrile infants ≤60 days with (n = 7) and without (n = 16) SARS-CoV-2 infection. Overall, we observed overlapping symptoms and duration of illness, with longer length of cough and nasal congestion among
the SARS-CoV-2-positive infants. |
|
McMahon, JH, Lau, et al |
Trials |
Therapeutics| Thérapeutique RCT |
The primary objective of the study was to determine the efficacy of a candidate antiviral on time to virological cure
compared to standard of care within 14 days of randomisation. The secondary objectives were: to determine the safety of the antiviral; to determine the clinical benefit of the antiviral over placebo according to the WHO 7-point ordinal scale; to determine
the clinical benefit of the antiviral over placebo on time to resolution of clinical symptoms; to determine the effect of the antiviral over placebo on biomarkers of inflammation and immune activation TRIAL. This is a multi-centre, triple-blind, randomised
placebo controlled phase II, 2-arm trial with parallel-group design with allocation ratio 1:1. The first candidate antiviral is favipiravir Arm 1: Favipiravir 1800 mg favipiravir BD on Day 1 followed by 800 mg BD favipiravir for the next 13 days. Arm 2: Placebo.
The study is registered on clinicaltrials.gov NCT04445467. |
|
|
Ménard, T, Bowling, et al |
Contemp Clin Trials Commun |
Healthcare Response | Réponse des soins de santé |
The world has seen a shift in the ways of working during the Covid-19 pandemic. Routine activities performed at the
clinical investigator sites (e.g. on-site audits) that are a part of Quality Assurance (QA) have not been feasible at this time. Analytics has played a huge role in contributing to our continued efforts of ensuring quality during the conduct of a clinical
trial. Decisions driven through data, now more than ever, heavily contribute to the efficiency of QA activities. In this report, we share the approach we took to conduct QA activities for the COVACTA study (to treat Covid-19 pneumonia) by leveraging analytics. |
|
|
Meyer, CJ, Hardy, et al |
World Dev |
Public Health response| Interventions de santé publique |
In a globalized world, pandemics transmit impacts through markets. We document employment changes, coping strategies,
and welfare of garment factory workers in Ethiopia's largest industrial park during the early stages of the Coronavirus Disease 2019 pandemic. We field a phone survey of female workers during a two month period in which cases are rapidly rising globally, but
not locally. Our data suggest significant changes in employment, high levels of migration away from urban areas to rural areas if women are no longer working, and high levels of food insecurity. These findings compel a research and policy focus on documenting
and mitigating the market-reach of pandemics on low-income workers at the margins. |
|
|
A marked decrease in Preterm Deliveries during
the COVID-19 Pandemic |
Meyer, R, Friedrich, et al |
Am J Obstet Gynecol |
Healthcare Response | Réponse des soins de santé |
We aimed to determine the change in PTB rate and neonatal outcomes during the pandemic in comparison to prepandemic
periods by evaluating multiple obstetrical characteristics, during more than three pandemic months. We compared maternal, obstetrical and neonatal outcomes of singleton pregnancies at the Sheba Medical Center, Israel, during three periods: from 20/03/2020
(date of implementation of governmental state of lockdown) to 27/06/2020 (group 1), a parallel period in 2019 (group 2), and to another group that included the parallel annual periods in 2011-2019 (group 3) (see Table). We also compared maternal and pregnancy
characteristics during the pandemic and corresponding prepandemic period in 2019 between pregnancies complicated by PTB <34(0/7) versus ≥34(0/7) weeks. Multivariate regression analysis was performed in order to study independent factors associated with PTB.
There were 2,594 deliveries during the pandemic period (group 1) and 2,742 and 28,686 deliveries in the prepandemic periods (groups 2 and 3, respectively). Maternal and obstetrical characteristics did not differ between groups 1 and 2. Predelivery hemoglobin
levels were higher in the pandemic period. PTB <34(0/7) weeks rate was significantly lower in the pandemic period compared to group 2 (OR 0.45 95% CI 0.30-0.68, p<0.001), as was the rate of composite neonatal outcome (OR 0.76 95% CI 0.59-0.96, p=0.023). Age,
body mass index, parity, diabetes rates and hematologic characteristics differed between groups 1 and 3 with significantly higher predelivery hemoglobin levels in group 1. PTB <34(0/7) weeks rate was lower in the pandemic period (OR 0.60 95% CI 0.41-0.85,
p=0.004). On multivariate regression analysis, delivering during the pandemic period was independently associated with a decreased risk for delivery <34(0/7) weeks (adjusted OR 0.29, 95% CI 0.15-0.56, p=0.001). We observed more than 50% reduction in the rate
of PTB <34(0/7) weeks of gestation, possibly resulting in improved neonatal outcome. |
|
The first wave of COVID-19 in Malta; a national
cross-sectional study |
Micallef, S, Piscopo, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this paper is to identify key factors that contributed to the low mortality rates in Malta. This is a retrospective,
observational, nationwide study which evaluates outcomes of patients during the first wave of the pandemic in Malta, from the 7th of March to the 24th of April 2020. Data was collected on demographics and mode of transmission. Hospitalization rates to Malta's
main general hospital, Mater Dei Hospital, length of in-hospital stay, intensive care unit admissions and 30-day mortality were also analyzed. There were 447 confirmed cases in total; 19.5% imported, 74.2% related to community transmission and 6.3% nosocomially
transmitted. Ninety-three patients (20.8%) were hospitalized, of which 4 were children. Patients with moderate-severe disease received hydroxychloroquine and azithromycin, in line with evidence available at the time. A total of 4 deaths were recorded, resulting
in an all-cause mortality of 0.89%. Importantly, all admitted patients with moderate-severe disease survived to 30-day follow up. Effective public health interventions, widespread testing, remote surveillance of patients in the community and a low threshold
for admission are likely to have contributed to these favorable outcomes. Hospital infection control measures were key in preventing significant nosocomial spread. |
|
Mobaied, S |
MethodsX |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission |
In this paper, we present the Risk of Vulnerability to COVID-19 in War Zones Index "Id_Covid19_WZ". This index was
calculated based on several factors and by using spatial data. A risk map was then created from this data developed for the north-west of Syria, an area where there has been intense fighting for several years. |
|
|
First report in Japan of a delivery of a woman with the 2019 novel
coronavirus disease |
Mochizuki, J, Nakamura, et al |
J Obstet Gynaecol Res |
Clinical data| Données cliniques |
On April 2, 2020, we received a maternal transport from a local city hospital of a pregnant woman (38 weeks and 0 days
of gestation) in her 20s, who had the 2019 novel coronavirus disease (COVID-19). We performed an emergency cesarean section with spinal anesthesia because of an abnormal fetal heart rate pattern. A healthy 3106-g male baby was delivered. All the severe acute
respiratory syndrome coronavirus 2 polymerase chain reaction tests of nasal and oral discharges, anal swabs and blood samples of the neonate at 9 h, 30 h and 4 days after birth were negative. Because the mother was diagnosed as having COVID-19 pneumonia, the
neonate was given formula milk. The mother's nasal discharge samples at 20 and 21 days were negative. The mother first held her baby in her arms on the 22nd day after birth, and they were discharged on the following day. To the best of our knowledge, this
is the first report in Japan of a delivery of a baby from a woman infected with COVID-19. |
|
Mohammed, M, Muhammad, et al |
J Racial Ethn Health Disparities |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to evaluate the independent risk factors associated with mortality among patients with COVID-19 in
Africa. A total of 1028 confirmed cases of COVID-19 from Africa with definite survival outcomes were identified retrospectively from an open-access individual-level worldwide COVID-19 database. Multivariable logistic regression was conducted to determine the
risk factors that independently predict mortality among patients with COVID-19. Of the 1028 cases included in study, 432 (42.0%) were females with a median (interquartile range, IQR) age of 50 (24) years. Older age (adjusted odds ratio {aOR} 1.06; 95% confidence
intervals {95% CI}, 1.04-1.08]), presence of chronic disease (aOR 9.63; 95% CI, 3.84-24.15]), travel history (aOR 2.44; 95% CI, 1.26-4.72]), as well as locations of Central Africa (aOR 0.14; 95% CI, 0.03-0.72]) and West Africa (aOR 0.12; 95% CI, 0.04-0.32])
were identified as the independent risk factors significantly associated with increased mortality among the patients with COVID-19. Among patients with COVID-19 in Africa, older age, presence of chronic disease, travel history, and the locations of Central
Africa and West Africa were associated with increased mortality. |
|
|
Experiences of Women Who Gave Birth in US Hospitals
During the COVID-19 Pandemic |
Mollard, Elizabeth, Wittmaack, et al |
medRxiv |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
The purpose of this study was to describe the experiences of women who gave birth in a US hospital during the COVID-19
pandemic. Women who gave birth between March and July 2020 completed a survey on the experience of giving birth during a pandemic. 885 women were consented and participated in the study. 22.5% of women reported hypertension, 33.8% reported anxiety, 18.6% reported
depression, and 1.13% reported testing positive for COVID-19. 61% of women reported inadequate support for childbirth, and 20.5% reported that they did not feel safe giving birth in the hospital. Women who tested positive for COVID-19 were more likely to be
of Asian race, have a cesarean section, not have a birth partner present, and discontinue breastfeeding before 6 weeks. Pandemic related changes to maternity care practices may have impacted birthing women's perceptions of safety and support in the hospital
environment and affected symptoms of stress. |
|
Mon-López, D, Bernardez-Vilaboa, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
The purpose of this work is to evaluate the effects of confinement due to COVID-19 isolation on visual function, considering
insufficient convergence as one of the possible effects of living the whole day in a reduced space. We pass a Convergence Insufficiency Symptom Survey (CISS) among 235 people to detect their habits before and after 25 confinement days. The data collection
protocol consisted on a Google forms questionnaire included two parts: the first with current data (isolation period) and a second with pre-isolation period data. Differences between the pre-isolation and isolation period were calculated using the related
paired T-tests. When statistically significant differences were found, the effect size was estimated using the Cohen's d index (d). The reduction in physical activity levels during confinement were related to the increase in total number of minutes of screen
consumption from 433.49 min to 623.97 min per day (d = 0.67; 44.01%). The CISS scores were increased by more than 43% during confinement. The increase in convergence insufficiency was 100% after the studied isolation period of 25 days. The 92.19% increase
in television use during 25 days of confinement is not responsible for the increase in convergence insufficiency. However, due to the increase in the use of PCs in this period, there is a notable increase in convergence insufficiency. Therefore, we can conclude
that not all increases in tasks with electronic devices are responsible for the increase in convergence insufficiency. |
|
|
Montalva, L, Haffreingue, et al |
Pediatr Surg Int |
Healthcare Response | Réponse des soins de santé |
The aim of the study was to evaluate the impact of the COVID-19 pandemic-related lockdown on management and outcomes
of children with acute appendicitis. A retrospective cohort study was conducted, including children treated for acute appendicitis (January 20th-May 11th, 2020). The data regarding the severity of appendicitis and outcome were collected and compared for two
time periods, before and after the nationwide lockdown (March 17th, 2020). The number of cases of acute appendicitis increased by 77% during the lockdown (n = 39 vs. n = 69, p = 0.03). During the lockdown, children treated for appendicitis were older (11.1
vs. 8.9 years, p = 0.003), and were more likely to live more than 5 km away from our institution (77% vs. 52%, p = 0.017). There was no difference in terms of length of hospital stay, rate of postoperative intra-abdominal abscess, ER visits, and readmissions
between both periods. Three children (4%) were diagnosed with COVID-19 and appendicitis. |
|
|
Moore, SC, Penrice-Randal, et al |
Viruses |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Sequencing strategies that underpin molecular epidemiology and inform virus biology in patients should take these factors
into account. A long amplicon/read length-based RT-PCR sequencing approach focused on the Oxford Nanopore MinION/GridION platforms was developed to identify and sequence the SARS-CoV-2 genome in samples from patients with or suspected of COVID-19. The protocol,
termed Rapid Sequencing Long Amplicons (RSLAs) used random primers to generate cDNA from RNA purified from a sample from a patient, followed by single or multiplex PCRs to generate longer amplicons of the viral genome. The base protocol was used to identify
SARS-CoV-2 in a variety of clinical samples and proved sensitive in identifying viral RNA in samples from patients that had been declared negative using other nucleic acid-based assays (false negative). Sequencing the amplicons revealed that a number of patients
had a proportion of viral genomes with deletions. |
|
|
Morales, DX, Morales, et al |
J Racial Ethn Health Disparities |
Public Health response| Interventions de santé publique |
This cross-sectional study on household food insecurity during COVID-19 used data from a nationally representative
sample of US households through the 2020 Household Pulse Survey (HPS) (including all 50 states and the District of Columbia, n = 74,413 households). Six generalized estimating equation (GEE) models were estimated, and the results indicated that households
headed by Blacks, Asians, Hispanics, or other racial/ethnic minorities were not significantly more food insecure than White households during the pandemic. However, among food-insecure households, Black households were more likely to report that they could
not afford to buy more food; Asian and Hispanic households were more likely to be afraid to go out to buy food; Asian households were more likely to face transportation issues when purchasing food; while White households were more likely to report that stores
did not have the food they wanted. Moreover, racial/ethnic minorities were significantly less confident about their household food security for the next 4 weeks than Whites. |
|
|
68Ga-PSMA PET/CT
With Incidental Finding of COVID-19 in an Asymptomatic Patient |
Morón, S, González, et al |
Clin Nucl Med |
Clinical data| Données cliniques |
A 70-year-old man with prostate adenocarcinoma was diagnosed by transrectal biopsy, with Gleason of 4 + 5 and initial
PSA of 225 ng/mL since March 2020. Ga-PSMA PET/CT was performed as part of initial staging. The images showed an enlarged prostate with focal PSMA uptake in both lobes. Retroperitoneal and pelvic lymph nodes with moderate uptake of PSMA were shown. Another
finding was a moderate PSMA uptake in the both lung parenchymas associated with opacities in CT. The patient denied any symptoms of coronavirus disease and was referred to the emergency department for RT-PCR COVID-19, and the result was positive. |
|
Silent hypoxia: higher NO in red blood cells of COVID-19
patients |
Mortaz, E, Malkmohammad, et al |
BMC Pulm Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Intracellular levels of nitric oxide (NO) play an important role in the vasodilation of small vessels. To elucidate
the intracellular levels of NO inside of RBCs in COVID-19 patients compared with that of healthy control subjects. We recruited 14 COVID-19 infected cases who had pulmonary involvement of their disease, 4 non-COVID-19 healthy controls (without pulmonary involvement
and were not hypoxic) and 2 hypoxic non-COVID-19 patients subjects who presented at the Masih Daneshvari Hospital of Tehran, Iran between March-May 2020. Whole blood samples were harvested from patients and intracellular NO levels in 1 × 10(6) red blood cells
(RBC) was measured by DAF staining using flow cytometry (FACS Calibour, BD, CA, USA). The Mean florescent of intensity for NO was significantly enhanced in COVID-19 patients compared with healthy control subjects (P ≤ 0.05). As a further control for whether
hypoxia induced this higher intracellular NO, we evaluated the levels of NO inside RBC of hypoxic patients. No significant differences in NO levels were seen between the hypoxic and non-hypoxic control group. This pilot study demonstrates increased levels
of intracellular NO in RBCs from COVID-19 patients. Future multi-centre studies should examine whether this is seen in a larger number of COVID-19 patients and whether NO therapy may be of use in these severe COVID-19 patients. |
|
Mostafa, MK, Gamal, et al |
J Environ Manage |
Public health interventions*| Interventions de santé publique |
Using Egypt as a case study, this paper presents the impact of COVID-19 pandemic on air pollution levels by studying
nitrogen dioxide (NO(2)), ozone (O(3)), particulate matter represented in absorbing aerosol index (AAI), carbon monoxide (CO), and greenhouse gas (GHG) emissions. The paper also highlights the impact of COVID-19 pandemic on other environmental indicators including
environmental noise, medical and municipal solid wastes. The paper presents the Egyptian COVID-19 story from its different angles including the development of confirmed COVID-19 cases, containment measures from the government, the impact on the country's economy
and the national energy consumption so as to effectively evaluate the effect on both the air pollution levels and the other studied environmental indicators. |
|
|
Mottaleb, KA, Mainuddin, et al |
PLoS One |
Economics | Économie |
This study examines the food security and welfare impacts of the COVID-19 induced lockdown on daily wage workers both
in the farm and nonfarm sectors in Bangladesh. Using information from more than 50,000 respondents complied with the 2016-17 Household Income and Expenditure Survey (HIES) in Bangladesh, this study estimates daily wage rates as Bangladesh Taka (BDT) 272.2
in the farm sector and BDT 361.5 in the nonfarm sector. Using the estimated daily wage earnings, this study estimates that a one-day complete lockdown generates a US$64.2 million equivalent economic loss only considering the wage loss of the daily wage workers.
After estimating the daily per capita food expenditure separately for farm and nonfarm households, this study estimates a minimum compensation package for the daily wage-based farm and nonfarm households around the US $ 1 per day per household to ensure minimum
food security for the daily wage-based worker households. |
|
|
Muhammad, AI, Boynton, et al |
Respir Med Case Rep |
Clinical data| Données cliniques |
To the best of our knowledge,there is no case report or data published regarding COVID pneumonitis presenting initially
as pneumothorax.There are 3 case reports published to-date (30/5/2020) reporting secondary pneumothorax as complication in later stages of Acute respiratory distress syndrome (ARDS) secondary to COVID-19 in non-ventilated patients. We present here a case of
COVID-19 disease presenting as tension pneumothorax after a week of symptoms and developing a second pneumothorax on other side post mechanical ventilation. |
|
|
Myhre, PL, Prebensen, et al |
Circulation |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The prognostic importance of GDF-15 in COVID-19 is unknown. Consecutive, hospitalized patients with laboratory-confirmed
infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and symptoms of COVID-19 were enrolled in the prospective, observational COVID MECH study. Biobank samples were collected at baseline, day 3 and day 9. The primary endpoint was admission
to the intensive care unit or death during hospitalization, and the prognostic performance of baseline and serial GDF-15 concentrations were compared with that of established infectious disease and cardiovascular biomarkers. Of the 123 patients enrolled, 35
(28%) reached the primary endpoint; these patients were older, more often had diabetes mellitus, had lower oxygen saturations and higher National Early Warning Score on baseline. Baseline GDF-15 concentrations were elevated (>95th percentile in age-stratified
healthy individuals) in 97 (79%), and higher concentrations were associated with detectable SARS-CoV-2 viremia and hypoxemia (both p<0.001). Patients reaching the primary endpoint had higher concentrations of GDF-15 (median 4225 IQR 3197-5972] pg/mL vs 2187
1344-3620] pg/mL, p<0.001). The C-statistic value was 0.78 (95% confidence interval 0.70-0.86). The association between GDF-15 and outcome persisted after adjusting for age, sex, race, body mass index, estimated glomerular filtration rate and previous myocardial
infarction, heart failure or atrial fibrillation (p<0.001), and was superior and incremental to interleukin-6, C-reactive protein, procalcitonin, ferritin, D-dimer, cardiac troponin T and N-terminal pro-B-type natriuretic peptide. Increase in GDF-15 from baseline
to day 3 was also greater in patients reaching the primary endpoint (median 1208 IQR 0-4305] pg/mL versus -86 IQR -322-491] pg/mL, p<0.001). GDF-15 is elevated in the majority of patients hospitalized with COVID-19, and higher concentrations are associated
with SARS-CoV-2 viremia, hypoxemia and worse outcome. |
|
|
Different mutations in SARS-CoV-2 associate with
severe and mild outcome |
Nagy, Adam, Pongor, et al |
medRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
We correlated protein-level mutations in the SARS-CoV-2 virus to clinical outcome. Mutations in viral sequences from
the GISAID virus repository were evaluated by using hCoV-19/Wuhan/WIV04/2019 as the reference. Patient outcomes were classified as mild disease, hospitalization and severe disease (death or documented treatment in an intensive-care unit). Chi-square test was
applied to examine the association between each mutation and patient outcome. False discovery rate was computed to correct for multiple hypothesis testing and results passing a FDR cutoff of 5% were accepted as significant. Mutations were mapped to amino acid
changes for 2,120 non-silent mutations. Mutations correlated to mild outcome were located in the ORF8, NSP6, ORF3a, NSP4, and in the nucleocapsid phosphoprotein N. Mutations associated with inferior outcome were located in the surface (S) glycoprotein, in
the RNA dependent RNA polymerase, in the 3'-to5' exonuclease, in ORF3a, NSP2 and N. Mutations leading to severe outcome with low prevalence were found in the surface (S) glycoprotein and in NSP7. Five out of 17 of the most significant mutations mapped onto
a 10 amino acid long phosphorylated stretch of N indicating that in spite of obvious sampling restrictions the approach can find functionally relevant sites in the viral genome. We demonstrate that mutations in the viral genes may have a direct correlation
to clinical outcome. |
|
Hepcidin levels predict COVID-19 severity and mortality in a cohort
of hospitalized Italian patients |
Nai, A, Lorè, et al |
Am J Hematol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to determine the relative contribution of hepcidin upregulation to the disrupted iron homeostasis
in COVID-19. Hepcidin levels were analyzed in 111 Italian COVID-19 patients admitted to San Raffaele University Hospital in Milan. Blood samples were obtained at admission, plasma immediately retrieved and frozen until analyzed for the concentration of iron,
hepcidin, the major regulator of iron homeostasis (ELISA kit from Intrinsic LifeSciences), proinflammatory markers as C-reactive protein (CRP) and ferritin, and cytokines with a role in hepcidin modulation, as interleukin IL6, IL1, TNF and Interferon
gamma (IFN). Overall our data suggest that in COVID-19 hepcidin can be considered a marker of morbidity and outcome, of special value for severely compromised patients in ICU. |
|
Nasser, Z, Fares, et al |
BMC Oral Health |
Healthcare Response | Réponse des soins de santé |
This study aims to assess the knowledge and practice of dentists toward the COVID-19 epidemic in Lebanon. We conducted
an online survey using the snowball-sampling technique. Information on socio-demographic data, knowledge, practice, and additional information required concerning COVID-19 were collected. ur results showed that the majority of the Lebanese dentists had good
knowledge (91.3%), and nearly half of the respondents had a good practice (58.7%) regarding COVID-19. The most common information source was the World Health Organization (73.7%). Multiple linear regression showed that specialist dentists who completed training
on COVID-19 with a high level of knowledge had better practice. Lebanese dentists revealed good knowledge regarding COVID-19. However, dentists had limited comprehension of the extra precautionary measures that protect the dental staff and patients from this
virus. |
|
|
Nasuelli, NA, Pettinaroli, et al |
Neurol Sci |
Clinical data| Données cliniques |
We found four patients with some characteristic phenotype in our ICU, characterized by focal hypotrophies of the shoulder
girdle and the bilateral peroneal district and underlying critical illness neuro-myopathy. In our opinion, these hypotrophies are secondary to the prone position. Is our intention to start early treatment protocol with electrostimulation to evaluate the effectiveness
in the prevention of critical illness and focal hypotrophies in ICU SARS-CoV-2 patients, to increase chances of returning to a preinfection functional status. |
|
|
Computational and theoretical exploration for
clinical suitability of Remdesivir drug to SARS-CoV-2 |
Nayeem, SM, Sohail, et al |
Eur J Pharmacol |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
A methodology for the exploration of clinical suitability of Remdesivir drug to SARS-CoV-2 main protease based on the
computational, theoretical analysis pertinent to Gibb's free energy computed from the Molecular Dynamic simulations with OPLS-AA force field at 300 K/atmospheric pressure and the variation of thermodynamic potentials over the entire simulation run of 100 ns.
This study emphasized the suitability of Remdesivir drug to SARS-CoV-2 protein and the same is emphasized by the results of global clinical trials. This methodology can be applied for future design, development of more specific repurposed inhibitors for the
treatment of SARS-CoV-2 infection. |
|
Nchioua, R, Kmiec, et al |
mBio |
Coronavirology| Coronavirologie Immunology | Immunologie |
We show that zinc finger antiviral protein (ZAP), which preferentially targets CpG dinucleotides in viral RNA sequences,
restricts SARS-CoV-2. We further demonstrate that ZAP and its cofactors KHNYN and TRIM25 are expressed in human lung cells. Type I, II, and III IFNs all strongly inhibited SARS-CoV-2 and further induced ZAP expression. Comprehensive sequence analyses revealed
that SARS-CoV-2 and its closest relatives from horseshoe bats showed the strongest CpG suppression among all known human and bat coronaviruses, respectively. Nevertheless, endogenous ZAP expression restricted SARS-CoV-2 replication in human lung cells, particularly
upon treatment with IFN-α or IFN-γ. Both the long and the short isoforms of human ZAP reduced SARS-CoV-2 RNA expression levels, but the former did so with greater efficiency. Finally, we show that the ability to restrict SARS-CoV-2 is conserved in ZAP orthologues
of the reservoir bat and potential intermediate pangolin hosts of human coronaviruses. Altogether, our results show that ZAP is an important effector of the innate response against SARS-CoV-2, although this pandemic pathogen emerged from zoonosis of a coronavirus
that was preadapted to the low-CpG environment in humans. Our findings indicating that type II interferon is particularly efficient against SARS-CoV-2 and that ZAP restricts this pandemic viral pathogen might promote the development of effective immune therapies
against COVID-19. |
|
|
Favourable perioperative outcomes for children with SARS-CoV-2 |
Nepogodiev, D |
Br J Surg |
Clinical data| Données cliniques |
CovidSurg is a multicentre, observational, international cohort study of surgical patients with SARS‐CoV‐2 infection
confirmed within 7 days before or 30 days after surgery. To better understand the surgical risks for children with SARS‐CoV‐2, we summarized outcomes in children from CovidSurg who had surgery between January 1 and April 30, 2020. Of the 5,388 patients in
CovidSurg within this timeframe, 88 were children 16 years of age or younger. Data were contributed by 52 hospitals in 21 countries. 56 (63·6%) patients were boys. Diagnosis of SARS‐CoV‐2 was preoperative in 48 (56%). Most children underwent emergency surgery
(89%). Benign disease was the most frequent indication for surgery (81%) followed by trauma (11%) and cancer (8%). Overall, the 30‐day postoperative mortality rate in children was 1·1% (1/88). Pulmonary complications (pneumonia, unexpected postoperative ventilation,
and/or acute respiratory distress syndrome) occurred in 13·6% (12/88). Our study suggests that the surgical risks in children with SARS‐CoV‐2 are much lower than in adults, mirroring the lower morbidity of SARS‐CoV‐2 infection seen in children. |
|
Ng, QX, Lee, et al |
Emerg Med Australas |
Healthcare Response | Réponse des soins de santé |
OBJECTIVE: To understand the impact of COVID-19 restrictions on emergency medical services (EMS) utilisation and out-of-hospital
cardiac arrest (OHCA) outcomes in Singapore. METHODS: This was a retrospective observational study comparing data collected by the Singapore Civil Defence Force (SCDF) on EMS utilisation in Singapore from April 1 to May 31, 2020 to previous figures. RESULTS:
Overall, EMS call volume and total OHCAs remained comparable to past years, however, there was a considerable decrease in prehospital return of spontaneous circulation (ROSC) rates, albeit not statistically significant (p=0.078). CONCLUSION: The findings contribute
to a growing body of literature internationally on the potential impact of the COVID-19 pandemic on EMS utilisation and outcomes. This article is protected by copyright. All rights reserved. |
|
|
Association of ABO/Rh With SARS-CoV-2 Positivity: the Role of Race/Ethnicity in a Female
Cohort |
Niles, JK, Karnes, et al |
Am J Hematol |
Epidemiology| Épidémiologie |
Describe the first large-scale observational study investigating the associations between ABO group/Rh types with SARS-CoV-2
positivity, by major race/ethnicity. The study cohort comprised 276,536 females with matched SARS-CoV-2 and ABO-Rh results from all 50 US states and District of Columbia. There were 34,178 females who were SARS-CoV-2 positive. The SARS-CoV-2 positivity rate
was higher in both females under 30 years of age (15.1%) and those 30-39 (11.9%) than in females age 40 or over (10.1%). The most common blood type was O+ (44.7%), followed by A+ (30.1%); B+ (11.9%); O- (4.7%); A- (3.8%); AB+ (3.3%); B- (1.2%); and AB- (0.4%).
The SARS-CoV-2 positivity rate was 38% higher in Rh+ patients (12.7%) than in Rh- patients (9.2%). The SARS-CoV-2 positivity rate was also significantly higher among type O patients (13.0%) than among type A (11.8%), type B (11.9%), or type AB (11.4%) patients.
Our findings demonstrated that Rh positivity, independent of ABO blood group and race/ethnicity, was a statistically significant risk factor for SARS-CoV-2 positivity. Type O blood is slightly protective against SARS-CoV-2 positivity once race/ethnicity has
been considered. The multivariable model also demonstrated that the influence of Rh+ blood type was attenuated when adjusted for race/ethnicity, suggesting that the association between ABO/Rh and SARS-CoV-2 positivity is strongly influenced by race/ethnicity. |
|
Stay at home: implementation and impact of virtualising cancer genetic services
during COVID-19 |
Norman, ML, Malcolmson, et al |
J Med Genet |
Healthcare Response | Réponse des soins de santé |
Examined the impact of virtualising genetics services at Canada's largest cancer centre. The number of appointments
and new patients seen were maintained during virtual care. Likewise, there was a significant increase in the number of patients offered testing during virtual care who did not provide a blood sample (97.7% vs 74.1%), and a longer median time from the date
of pretest genetic counselling to the date a sample was given (0 vs 11 days). Referral volumes significantly decreased during virtual care (35 vs 22), which was accompanied by a decreased median wait time for first appointment (55 days vs 30 days). |
|
Divergent SARS-CoV-2-specific T and B cell responses in severe but not mild COVID-19
patients |
Oja, AE, Saris, et al |
Eur J Immunol |
Clinical data| Données cliniques Immunology | Immunologie |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the current coronavirus disease
2019 (COVID-19) pandemic. Understanding the immune response that provides specific immunity but may also lead to immunopathology is crucial for the design of potential preventive and therapeutic strategies. Here, we characterized and quantified SARS-CoV-2
specific immune responses in patients with different clinical courses. Compared to individuals with a mild clinical presentation, CD4+ T cell responses were qualitatively impaired in critically ill patients. Strikingly, however, in these patients the specific
IgG antibody response was remarkably strong. Furthermore, in these critically ill patients, a massive influx of circulating T cells into the lungs was observed, overwhelming the local T cell compartment, and indicative of vascular leakage. The observed disparate
T and B cell responses could be indicative of a deregulated immune response in critically ill COVID-19 patients. This article is protected by copyright. All rights reserved. |
|
Public perception of COVID-19 management and response in Nigeria: a cross-sectional
survey |
Oleribe, O, Ezechi, et al |
BMJ Open |
Public Health response| Interventions de santé publique |
Assessed the public perception of the response of government and its institutions to the COVID-19 pandemic in Nigeria.
Over 95% of the respondents had heard of COVID-19 (98.8%) and knew it is a viral disease (95.4%). The government and its institutions response to the pandemic were rated as poor, with the largest rating as poor for Federal President's Office (57.5%). Communication
(50.0%) and prevention messages (43.7%) received the highest perception good rating. Female respondents and those less than 40 years generally rated the governmental responses as poor. |
|
Omar, Amro Ahmed, Williams, et al |
Research Square prepub |
Clinical data| Données cliniques |
Examined the bacterial and fungal co-infections, antimicrobial treatment and clinical outcome in COVID-19 patients
in an acute Irish hospital. 42 patients met eligibility criteria for the study inclusion. Male/female ratio was 22/20 (52.4%/47.6%), median age of the patients was 64 years and the median duration of hospital stay was 11 day. In-hospital mortality rate was
3 (7.1%). Four laboratory confirmed co-infections were identified in 3 (7.1%) patients. All 3 patients were discharged home. Out of 42 patients, 12 (28.6%) patients received specific antiviral treatment. 34 (85.0%) patients were prescribed antimicrobials with
antibacterial effect and 3 (7.5%) antimicrobials with antifungal effect. |
|
|
Impaired natural killer cell counts and cytolytic activity in patients with
severe COVID-19 |
Osman, M, Faridi, et al |
Blood Adv |
Clinical data| Données cliniques Immunology | Immunologie |
Assessed the NK-cell functional activity and the associated cytokines and soluble mediators in hospitalized COVID-19
patients. Significantly impaired NK-cell counts and cytolytic activity were observed in COVID-19 patients when compared with healthy controls. Also, cytokines like interleukin 12 (IL12), IL15, and IL21 that are important for NK-cell activity were not detected
systematically. Serum concentrations of soluble CD25 (sCD25)/soluble IL2 receptor α (sIL2-Rα) were significantly elevated and were inversely correlated with the percentage of NK cells. Impaired NK-cell cytolytic activity together with other laboratory trends
including elevated sCD25 were consistent with a hyperinflammatory state in keeping with macrophage-activation syndrome. |
|
Oster, AM, Caruso, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Transmission Public Health Priorities| Priorités de santé
publique |
Analyzed temporal trends in percent positivity by age group in COVID-19 hotspot counties before and after their identification
as hotspots. Among 767 hotspot counties identified during June and July 2020, early increases in the percent positivity among persons aged ≤24 years were followed by several weeks of increasing percent positivity in persons aged ≥25 years. Addressing transmission
among young adults is an urgent public health priority. |
|
|
Ozturk, AB, Baççıoğlu, et al |
Int Arch Allergy Immunol |
Healthcare Response | Réponse des soins de santé |
Determine the attitudes and experiences of adult/pediatric allergists on allergy management during COVID-19. A total
of 183 allergists participated in the survey. Telemedicine was used for management of asthma (73%), allergic rhinitis (53%), atopic dermatitis (51%), chronic urticaria/angioedema (59%), drug hypersensitivity (45%), food allergy (48%), venom allergy (30%),
anaphylaxis (22%), and hereditary angioedema (28%). Thirty-one percent of the respondents discontinued subcutaneous immunotherapy (SCIT) during the COVID-19 pandemic. Thirty-four percent of the physicians reported interruption of systemic steroid use in asthma
patients, and 25% of the respondents discontinued biological therapy. |
|
|
Padhi, S, Massi, et al |
Eur J Pharmacol |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In an attempt to search for selective inhibitors against the SARS-CoV-2 which caused devastating of lives and livelihoods
across the globe, 415 natural metabolites isolated from several plants, fungi and bacteria, belonging to different classes, were investigated. The drug metabolism and safety profiles were computed in silico and the results showed seven compounds namely fusaric
acid, jasmonic acid, jasmonic acid methyl ester, putaminoxin, putaminoxin B and D, and stagonolide K were predicted to having considerable absorption, metabolism, distribution and excretion parameters (ADME) and safety indices. Molecular docking against the
receptor binding domain (RBD) of spike glycoprotein (S1) and the main protease (M(pro)) exposed the compounds having better binding affinity to main protease as compared to the S1 receptor binding domain. The docking results were compared to an antiviral drug
penciclovir reportedly of clinical significance in treating the SARS-CoV-2 infected patients. The results demonstrated the test compounds jasmonic acid, putaminoxin B and D bound to the HIS-CYS catalytic dyad as well as to other residues within the M(Pro)
active site with much greater affinity than penciclovir. The findings of the study suggest that these compounds could be explored as potential SARS-CoV-2 inhibitors, and could further be combined with the experimental investigations to develop effective therapeutics
to deal with the present pandemic. |
|
|
Pal, P, Ibrahim, et al |
Transfus Med |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Describe the outcomes of 17 critically ill patients with COVID-19, including six with haematological malignancies,
dis-playing varying ranges of severe illness and length of infection, who were treated with COVID-19 convalescent plasma (CCP) with marked clinical improvement. Ten men and seven women between the ages of 24 and 81 years (mean 56) received CCP following informed
consent. Most patients had multiple medical comorbidities, and 14 of the 17 patients were treated in the intensive care unit. All of our patients showed improvement following CCP and the most impressive effects were seen in patients when CCP was administered
early in their disease course. Two CCP infusions were used in three patients, and in each case, we saw an incremental improvement in patient oxygenation. |
|
|
Palacios, R, Patiño, et al |
Trials |
RCT |
Will evaluate the efficacy of two doses of the adsorbed vaccine COVID-19 (inactivated) produced by Sinovac in symptomatic
individuals, with virological confirmation of COVID-19, two weeks after the completion of the two-dose vaccination regimen. The primary efficacy endpoint is the incidence of symptomatic cases of virologically confirmed COVID-19 two weeks after the second vaccination.
The virological diagnosis will be confirmed by detection of SARS-CoV-2 nucleic acid in a clinical sample. The primary safety endpoint is the frequency of solicited and unsolicited local and systemic adverse reactions during the period of one week after vaccination
according to age group in adult (18-59 years old) and elder (60 years of age or older) subjects. Adverse reactions are defined as adverse events that have a reasonable causal relationship to vaccination. |
|
|
Paredes, MR, Apaolaza, et al |
Pers Individ Dif |
Public Health response| Interventions de santé publique |
The COVID-19 pandemic has potentially a serious impact on many people's mental well-being. This study analyses the
influence of the perceived threat of COVID-19 on subjective mental well-being with an online survey (n = 711). Findings confirmed the hypothesized model that provides a process explanation for this effect through the mediating influence of the activation of
future anxiety. In addition, results confirmed that this influence via future anxiety is moderated by resilience, a personality trait that enables individuals to cope better with stressful or traumatic events. Individuals with higher levels of resilience compared
to those with lower levels registered a lower impact of perceived Covid threat on future anxiety and, in turn, on subjective well-being. This study contributes theoretically to a better understanding of the factors that determine the impact of traumatic events
such as a pandemic on people's mental health. The implications of this study indicate interventions that may be carried out to minimize the pandemic's negative psychological consequences. |
|
|
Paschold, L, Simnica, et al |
J Clin Invest |
Clinical data| Données cliniques Immunology | Immunologie |
A considerable fraction of B cells recognize SARS-CoV-2 with germline-encoded elements of their B cell receptor resulting
in the production of neutralizing and non-neutralizing antibodies. We found that antibody sequences from different discovery cohorts shared biochemical properties and could be retrieved across validation cohorts confirming the stereotyped character of this
naive response in COVID-19. While neutralizing antibody sequences were found independently of disease severity in line with serological data, individual non-neutralizing antibody sequences were associated with fatal clinical courses suggesting detrimental
effects of these antibodies. We mined 200 immune repertoires of healthy individuals and 500 of patients with blood or solid cancers - all acquired prior to the pandemic - for SARS-CoV-2 antibody sequences. While the largely unmutated B cell rearrangements
occurred in a substantial fraction of immune repertoires from young and healthy individuals, these sequences were less likely found in individuals over 60 years of age and in cancer. This reflects B cell repertoire restriction in aging and cancer and may to
a certain extent explain the different clinical COVID-19 courses observed in these risk groups. Future studies will have to address if this stereotyped B cell response to SARS-CoV-2 emerging from unmutated antibody rearrangements will create long-lived memory. |
|
|
Characteristics and evolution of COVID-19 cases in
Brazil: mathematical modeling and simulation |
Passos, Carlos Augusto Cardoso, Vieira, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Analyzed the official data of COVID-19 in Brazil and used the Johnson-Mehl-Avrami-Kolmogorov (JMAK) equation to predict
the evolution of the disease. The model indicates that a nucleation rate is of fourth order, which indicates that Brazilians are crowding with no respect to measures of social distance and disease prevention. In our opinion, the political authorities were
unable to control the spread of the disease in Brazil, given that social mobility was interrupted by the federal and state governments. |
|
Patel, LG, Peck, et al |
Ophthalmology |
Public Health response| Interventions de santé publique |
Investigated the effect of the COVID-19 pandemic on the clinical presentation of acute, primary rhegmatogenous retinal
detachment (RRD). Eighty-two patients were included in the 2020 cohort compared to 111 patients in the 2019 primary control cohort. Significantly fewer patients presented with macula-on RRD in the 2020 cohort (24.4%) than in 2019 (49.5%). Patients in the 2020
cohort had worse median VA at presentation (LogMAR 1.00, Snellen 20/200 in 2020 versus LogMAR 0.48, Snellen 20/60 in 2019), fewer patients presenting within one day of symptoms (19.5% in 2020 vs 36.9% in 2019), and a greater proportion with primary proliferative
vitreoretinopathy (13.4% in 2020 vs 4.5% in 2019). In multivariate analysis, younger age and established patient status were independent predictors of macula-on status in the 2020 cohort. |
|
|
Pau, T, Vainio, et al |
Genomics |
Coronavirology| Coronavirologie |
The coronavirus pandemic became a major risk in global public health. The outbreak is caused by SARS-CoV-2, a member
of the coronavirus family. Though the images of the virus are familiar to us, in the present study, an attempt is made to hear the coronavirus by translating its protein spike into audio sequences. The musical features such as pitch, timbre, volume and duration
are mapped based on the coronavirus protein sequence. Three different viruses Influenza, Ebola and Coronavirus were studied and compared through their auditory virus sequences by implementing Haar wavelet transform. The sonification of the coronavirus benefits
in understanding the protein structures by enhancing the hidden features. Further, it makes a clear difference in the representation of coronavirus compared with other viruses, which will help in various research works related to virus sequence. This evolves
as a simplified and novel way of representing the conventional computational methods. |
|
|
An Evaluation of Neurosurgical Practices During the COVID-19 Pandemic |
Pelargos, PE, Chakraborty, et al |
World Neurosurg |
Healthcare Response | Réponse des soins de santé |
Examined how the COVID-19 pandemic has affected the neurosurgical workforce. There were 457 respondents throughout
the United States and Puerto Rico representing all practices types and subspecialties. Nearly all respondents reported hospital restrictions on elective surgeries. Most reported a decline in clinic and operative volume. Nearly 70% of respondents saw a decrease
in the work hours of their ancillary providers, and almost half (49.1%) of respondents had to downsize their practice staff, office assistants, nurses, schedulers, etc. Overall, 43.6% of survey responders had experienced a decline in income, while 27.4% expected
a decline in income in the upcoming billing cycle. More senior neurosurgeons and those with a private practice, whether solo or as part of a group, were more likely to experience a decline in income as a result of the pandemic as compared to their colleagues. |
|
Structural basis of SARS-CoV-2 polymerase inhibition
by Favipiravir |
Peng, Qi, Peng, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Determined the cryo-EM structure of Favipiravir bound to the replicating polymerase complex of SARS-CoV-2 in the pre-catalytic
state. This structure provides a missing snapshot for visualizing the catalysis dynamics of coronavirus polymerase, and reveals an unexpected base-pairing pattern between Favipiravir and pyrimidine residues which may explain its capacity for mimicking both
adenine and guanine nucleotides. These findings shed lights on the mechanism of coronavirus polymerase catalysis and provide a rational basis for developing antiviral drugs to combat the SARS-CoV-2 pandemic. |
|
Retinal findings in hospitalised patients with severe COVID-19 |
Pereira, LA, Soares, et al |
Br J Ophthalmol |
Clinical data| Données cliniques |
Identified retinal findings using dilated eye examination, which are possibly related to SARS-CoV-2 infection in hospitalised
patients with confirmed severe COVID-19. There were a total of 18 patients, nine (50%) male, median IQR age of 62.5 (12) years. Ten of the 18 patients (55.6%) had abnormalities on dilated eye examination. The main findings were flame-shaped haemorrhages (22.2%)
and ischaemic pattern lesions (cotton wool spots and retinal sectorial pallor) (22.2%), with one patient having both cotton wool spots and flame-shaped haemorrhages. |
|
COVID-19 deaths in people with intellectual disability in the UK and Ireland: descriptive
study |
Perera, B, Laugharne, et al |
BJPsych Open |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Identified comorbidities, demographic and clinical factors of those individuals with intellectual disability who have
died from COVID-19. Data on 66 deaths in individuals with intellectual disability were analysed. This group was younger (mean age 64 years) compared with the age of death in the general population because of COVID-19. High rates of moderate-to-profound intellectual
disability (n = 43), epilepsy (n = 29), mental illness (n = 29), dysphagia (n = 23), Down syndrome (n = 20) and dementia (n = 15) were observed. |
|
Two Cases of SARS-CoV-2 Infection in Pediatric Oncohematologic Patients in Spain |
Pérez-Heras, I, Fernandez-Escobar, et al |
Pediatr Infect Dis J |
Clinical data| Données cliniques |
Since December 2019, severe acute respiratory syndrome coronavirus 2 infection has spread worldwide. We all are concerned
about immunocompromised children, especially hematologic and oncologic pediatric patients. We want to share our experience with 2 pediatric cancer patients with severe acute respiratory syndrome coronavirus 2 infection. Both presented mild disease and good
outcome. No respiratory symptoms were identified, but both developed diarrhea, one probably secondary to lopinavir/ritonavir. Pediatric cancer patients may have milder disease than adults, but larger studies are needed to make conclusions. |
|
Perkin, MR, Heap, et al |
BMJ Open |
Epidemiology| Épidémiologie |
Reviewed deaths in a 6-week period during the COVID-19 pandemic commencing with the first death in the hospital from
COVID-19 on 12th of March 2020 and contrast this with the same period in 2019. Deaths in patients from the Black, Asian and minority ethnic (BAME) communities in the pandemic period significantly increased both in the COVID-19 group (OR=2.43) and the non-COVID
group (OR=1.76) during this time period and the increase was independent of differences in comorbidities, sex, age or deprivation. While the absolute number of deaths increased in 2020 compared with 2019, across all three groups the distribution of deaths
by age was very similar. Our analyses confirm major risk factors for COVID-19 mortality including male sex, diabetes, having multiple comorbidities and background from the BAME communities. |
|
|
Hyperbolic rules of the cooperative organization of eukaryotic and prokaryotic
genomes |
Petoukhov, SV |
Biosystems |
Coronavirology| Coronavirologie |
The author's method of oligomer sums for analysis of oligomer compositions of eukaryotic and prokaryotic genomes is
described. The use of this method revealed the existence of general rules for the cooperative oligomeric organization of a wide list of genomes. These rules are called hyperbolic because they are associated with hyperbolic sequences including the harmonic
progression 1, 1/2, 1/3, .., 1/n. These rules are demonstrated by examples of quantitative analysis of many genomes from the human genome to the genomes of archaea and bacteria. The hyperbolic (harmonic) rules, speaking about the existence of algebraic invariants
in full genomic sequences, are considered as candidates for the role of universal rules for the cooperative organization of genomes. The results concerns additionally the problem of the origin of life. The described phenomenological results were obtained as
consequences of the previously published author's quantum-information model of long DNA sequences. The oligomer sums method was also applied to the analysis of long genes and viruses including the COVID-19 virus; this revealed, in characteristics of many of
them, the phenomenon of such rhythmically repeating deviations from model hyperbolic sequences, which are associated with DNA triplets. In addition, an application of the oligomer sums method is shown to the analysis of amino acid sequences in long proteins
like the protein Titin. The topics of the algebraic harmony in living bodies and of the quantum-information approach in biology are discussed. |
|
Piazza, M, Xodo, et al |
Vascular |
Healthcare Response | Réponse des soins de santé |
Describe the protocols adopted and to evaluate their impact during the acute phase of Coronavirus spread, focusing
on the management of elective and urgent/emergent surgery, outpatients activity, and also health staff preservation from intra-hospital Coronavirus disease 2019 infection. The number of urgent or emergent aortic cases remained stable during the two months
period, while the number of Hospital admissions via Emergency Room related to critical limb ischemia decreased after national lockdown by about 20%. Elective vascular surgery was scaled down by 50% starting from 9 March; 35% of scheduled elective cases refused
hospitalization during the lockdown period and 20% of those contacted for hospitalization where postponed due to fever, respiratory symptoms, or close contacts with Coronavirus disease 2019 suspected cases. Elective surgery reduction did not negatively influence
overall carotid or aortic outcomes, while we reported a higher major limb amputation rate for critical limb ischemia (about 10%, compared to 4% for the standard practice period). We found that 4% of health-care providers on the floor had an asymptomatic positive
swab test. Among 22 vascular doctors, 3 had a confirmed Coronavirus disease 2019 infection (asymptomatic); a total of 72 swab were performed during this period; no cases of severe Coronavirus disease 2019 (deaths or requiring intensive care treatment) infection
were reported within this period for the staff or hospitalized patients. |
|
|
COVID-19 Emergency Sick Leave Has Helped Flatten The Curve In The United States |
Pichler, S, Wen, et al |
Health Aff (Millwood) |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Investigated whether the coronavirus disease 2019 (COVID-19) emergency sick leave provision of the bipartisan Families
First Coronavirus Response Act (FFCRA) reduced the spread of the virus. Using a difference-in-differences strategy, we compare pre-post FFCRA changes in newly reported COVID-19 cases in states where workers gained the right to take paid sick leave (treatment
group) to states where workers already had access to paid sick leave (control group). We adjust for differences in testing, day-of-the-week reporting, structural state differences, general virus dynamics, and policies such as stay-at-home orders (SHO). Compared
to the control group and relative to the pre-FFCRA period, states that gained access to paid sick leave through FFCRA saw a statistically significant 400 fewer confirmed cases per day. This estimate translates into roughly 1 prevented COVID-19 case per day,
per 1300 workers who newly gained the option to take up to two weeks of paid sick leave. |
|
Pierron, D, Pereda-Loth, et al |
Nat Commun |
Clinical data| Données cliniques |
In response to the COVID-19 pandemic, many governments have taken drastic measures to avoid an overflow of intensive
care units. Accurate metrics of disease spread are critical for the reopening strategies. Here, we show that self-reports of smell/taste changes are more closely associated with hospital overload and are earlier markers of the spread of infection of SARS-CoV-2
than current governmental indicators. We also report a decrease in self-reports of new onset smell/taste changes as early as 5 days after lockdown enforcement. Cross-country comparisons demonstrate that countries that adopted the most stringent lockdown measures
had faster declines in new reports of smell/taste changes following lockdown than a country that adopted less stringent lockdown measures. We propose that an increase in the incidence of sudden smell and taste change in the general population may be used as
an indicator of COVID-19 spread in the population. |
|
|
Retinal involvement and ocular findings in COVID-19 pneumonia patients |
Pirraglia, MP, Ceccarelli, et al |
Sci Rep |
Clinical data| Données cliniques |
Evaluated the possible retinal involvement and ocular findings in severe COVID-19 pneumonia patients. A total of 43
SARS-CoV-2-positive pneumonia patients affected with COVID-19 pneumonia were included, including 25 males and 18 females, with a median age of 70 years. Except for one patient with unilateral posterior chorioretinitis of opportunistic origin, of whom aqueous
tap was negative for SARS-CoV-2, no further retinal manifestation related to COVID-19 infection was found in our cohort. We found 3 patients (7%) with bilateral conjunctivitis in whom PCR analysis on conjunctival swabs provided negative results for SARS-CoV-2.
No alterations in corneal sensitivity were found. We demonstrated the absence of retinal involvement in SARS-CoV-2 pneumonia patients. |
|
PMC7526399; Pulmonary Embolism After Acute Spinal Cord Injury and COVID-19 |
Pisano, TJ, Joki, et al |
Am J Phys Med Rehabil |
Clinical data| Données cliniques |
Acute spinal cord injury has an inherent increased risk for venous thromboembolism. In this case report, the patient
presented with bilateral lower limb weakness and sensory loss secondary to thoracic disc herniation. Incidentally, at the same time as the initial presentation, the patient was also found to have coronavirus virus disease 2019 without significant respiratory
symptoms. During hospitalization, the patient developed extensive bilateral lower limb deep vein thrombosis despite chemoprophylaxis. Therapeutic anticoagulation was initiated, yet several days later, he developed pleuritic chest pain. Computed tomography
angiography revealed bilateral pulmonary emboli. |
|
Piubelli, C, Deiana, et al |
Clin Microbiol Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Evaluated a possible association between the severity of clinical manifestations and viral load over time, during the
epidemiological transition from high to low transmission setting. The proportion of patients requiring intensive care significantly reduced from 6.7% in March, to 1.1% in April, and to none in May. As for viral load, we observed a trend of Ct increasing from
a median value of 24 (IQR 19-29) to 34 (IQR 29-37) between March and May, with a statistically significant difference between March and April. As the epidemiological context changes from high to low transmission setting, people are presumably exposed to a
lower viral load, which has been previously associated to less severe clinical manifestations. |
|
|
PMC7553152; Therapeutic MK-4482/EIDD-2801 Blocks SARS-CoV-2 Transmission in Ferrets |
Plemper, R, Cox, et al |
Res Sq |
Transmission Therapeutics| Thérapeutique Animal model | Modèle animal |
The COVID-19 pandemic is having a catastrophic impact on human health. Widespread community transmission has triggered
stringent distancing measures with severe socioeconomic consequences. Gaining control of the pandemic will depend on interruption of transmission chains until protective herd immunity arises. Ferrets and related members of the weasel genus transmit SARS-CoV-2
efficiently with minimal clinical signs, resembling spread in the young-adult population. We previously reported an orally efficacious nucleoside analog inhibitor of influenza viruses, EIDD-2801 (or MK-4482), that was repurposed against SARS-CoV-2 and is in
phase II/III clinical trials. Employing the ferret model, we demonstrate in this study high SARS-CoV-2 burden in nasal tissues and secretions that coincides with efficient direct-contact transmission. Therapeutic treatment of infected animals with twice-daily
MK-4482/EIDD-2801 significantly reduced upper respiratory tract SARS-CoV-2 load and completely suppressed spread to untreated contact animals. This study identifies oral MK-4482/EIDD-2801 as a promising antiviral countermeasure to break SARS-CoV-2 community
transmission chains. |
|
Docking and QSAR of Aminothioureas at the SARS-CoV-2 S-Protein-Human ACE2 Receptor
Interface |
Płonka, W, Paneth, et al |
Molecules |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Docking of over 160 aminothiourea derivatives at the SARS-CoV-2 S-protein-human ACE2 receptor interface, whose structure
became available recently, has been evaluated for its complex stabilizing potency and subsequently subjected to quantitative structure-activity relationship (QSAR) analysis. The structural variety of the studied compounds, that include 3 different forms of
the N-N-C(S)-N skeleton and combinations of 13 different substituents alongside the extensive length of the interface, resulted in the failure of the QSAR analysis, since different molecules were binding to different parts of the interface. Subsequently, absorption,
distribution, metabolism, and excretion (ADME) analysis on all studied compounds, followed by a toxicity analysis using statistical models for selected compounds, was carried out to evaluate their potential use as lead compounds for drug design. Combined,
these studies highlighted two molecules among the studied compounds, i.e., 5-(pyrrol-2-yl)-2-(2-methoxyphenylamino)-1,3,4-thiadiazole and 1-(cyclopentanoyl)-4-(3-iodophenyl)-thiosemicarbazide, as the best candidates for the development of future drugs. |
|
Poelman, MP, Gillebaart, et al |
Appetite |
Public Health response| Interventions de santé publique |
Assessed changes in eating behavior and food purchases among a representative adult sample in the Netherlands (n=1030),
five weeks into lockdown. The results show that most participants did not change their eating behaviors (83.0%) or food purchases (73.3%). However, socio-demographic differences were observed among those that reported changes during lockdown. Participants
with overweight and obesity were more likely to indicate to eat unhealthier during lockdown compared to participants with a healthy weight. Those with a high educational level were also more likely to indicate to eat unhealthier during lockdown compared to
those with a low educational level. Older participants were more likely to indicate to experience no differences in their eating behaviors compared to those of younger age. Of those that used meal delivery services before, 29.5% indicated to use meal delivery
services more frequently during lockdown. |
|
|
Clinical Characteristics of Hospitalized Patients with COVID-19 in Sofia, Bulgaria |
Popov, GT, Baymakova, et al |
Vector Borne Zoonotic Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Present the clinical manifestations of COVID-19 patients admitted to the Military Medical Academy, Sofia, Bulgaria.
One hundred thirty-eight COVID-19 patients were hospitalized and analyzed during the study period. The mean age was 52.9 years. Male was the dominant sex. The leading clinical signs were fever, fatigue, cough, and headache. On comparative analysis of both
groups (nonsevere and severe) was measured significant elevation of white blood cells (odds ratio [OR] = 1.238), C-reactive protein (OR = 1.021), creatinine (OR = 1.037), aspartate aminotransferase (OR = 1.014), lactate dehydrogenase (OR = 1.004), ferritin
(OR = 1.002), fibrinogen (OR = 2.028), and d-dimer (OR = 2.162) in severe group than in nonsevere group. Interleukin 6 was tested in 17.4% of patients and high value was found (38.6 pg/mL). |
|
Prabhu Navis, J, Leelarathna, et al |
Acta Diabetol |
Public Health response| Interventions de santé publique |
Assessed whether sensor-based outcomes pre- and during lockdown periods were different in a cohort of glucose sensor
users with T1D. Two hundred and sixty-nine T1D patients were identified as Freestyle Libre (FSL) (n = 190) or Dexcom G6 (n = 79) users. In patients with sensor use > 70%, compared to pre-lockdown period percentage TIR 3.9-10 mM (TIR) significantly increased
during 2 weeks into lockdown (period 1) (59.6 ± 18.2 vs. 57.5 ± 17.2%) and 3 weeks into lockdown (period 2) (59.3 ± 18.3 vs. 57.5 ± 17.2%). The proportion of patients achieving TIR ≥ 70% increased from 23.3% pre-lockdown to 27.8% in period 1 and 30.5% in period
2. A higher proportion also achieved the recommended time below and above range, and coefficient of variation in periods 1 and 2. Dexcom G6 users had significantly lower % time below range (< 3.9 mM) compared to FSL users during both lockdown periods (period
1: Dexcom G6 vs. FSL: 1.8% vs. 4%; period 2: 1.4% vs. 4%). Sensor-based glycaemic outcomes in people with T1D in the current cohort improved during COVID-19 lockdown, which may be associated with positive changes in self-management strategies. |
|
|
Pradhan, M, Chettri, et al |
Death Stud |
Public Health response| Interventions de santé publique |
The present study examined the fear of death among young adults in the wake of the COVID-19. It explored the association
between neuroticism and death anxiety during this pandemic crisis, and it also examined the mediating role of perceived stress in this relationship. An online survey of 200 participants, including both students and employed young adults, aged between 18 and
30 years, was conducted. Results showed that neuroticism was positively correlated to death anxiety; however, the relationship was completely mediated by perceived stress. The results and implications are discussed in light of the COVID-19 pandemic. |
|
|
Pranay, SY, N |
arXiv |
Coronavirology| Coronavirologie |
Causal inference is one of the most fundamental problems across all domains of science. We address the problem of inferring
a causal direction from two observed discrete symbolic sequences X and Y. We present a framework which relies on lossless compressors for inferring context-free grammars (CFGs) from sequence pairs and quantifies the extent to which the grammar inferred from
one sequence compresses the other sequence. We infer X causes Y if the grammar inferred from X better compresses Y than in the other direction. To put this notion to practice, we propose three models that use the Compression-Complexity Measures (CCMs) - Lempel-Ziv
(LZ) complexity and Effort-To-Compress (ETC) to infer CFGs and discover causal directions. We evaluate these models on synthetic and real-world benchmarks and empirically observe performances competitive with current state-of-the-art methods. Lastly, we present
a unique application of the proposed models for causal inference directly from pairs of genome sequences belonging to the SARS-CoV-2 virus. Using a large number of sequences, we show that our models capture directed causal information exchange between sequence
pairs, presenting novel opportunities for addressing key issues such as contact-tracing, motif discovery, evolution of virulence and pathogenicity in future applications. |
|
|
Erythema Pernio-like in four Adolescents in the era of the Coronavirus-2
Infection |
Promenzio, L, Arcangeli, et al |
Rev Recent Clin Trials |
Clinical data| Données cliniques |
Report cutaneous manifestation of SARS-CoV-2 infection in 4 adolescents. Fourteen days after a flu-like syndrome,
adolescents exhibited skin lesions to toes and feet. These lesions were rounded, with blurred limits, with a 5-15 mm diameter, red-violaceous-bluish colored, sometimes resulting in bullous lesions in correspondence of the central or apical portion, which tended
to be covered with blackish crusts after evolution. Lesions were also accompanied by pain of variable intensity and evolved within two or three weeks to self-resolution without particular sequelae. In two patients, pharyngeal and nasal swabs were negative
for SARS-CoV-2 infection, at the presentation of skin lesions. After 2 months from clinical manifestations, patients were tested positive for SARS-CoV-2 antibodies. |
|
Quaquarini, E, Saltalamacchia, et al |
Cancers (Basel) |
Healthcare Response | Réponse des soins de santé |
Investigated the management of cancer patients and oncological treatments during the COVID-19 pandemic and to describe
the containment measures performed in our outpatient clinic at Pavia (Lombardy). A significant reduction in access for therapy was seen when compared with 2019 (2590 versus 2974). In 2020, 63 patients delayed treatment: 38% for "pandemic fear", 18% for travel
restrictions, 13% for quarantine, 18% for flu syndrome other than COVID-19, and 13% for worsening of clinical conditions and death. Only 7/469 patients developed COVID-19. A significant reduction in radiological exams was found in 2020 versus all the other
years considered (211 versus 360, 355, 385, 390 for the years 2020, 2019, 2018, 2017, and 2016, respectively). The low incidence of COVID-19 among our cancer patients, along with the hospital policy to control infection, enabled safe cancer treatment and a
continuum of care in most patients, while a small fraction of patients experienced a therapeutic delay due to patient-related reasons. |
|
|
Rahman, MM, Bodrud-Doza, et al |
Environ Res |
Public Health response| Interventions de santé publique |
This study aimed to assess the potential impact of a simultaneous strike of climatic hazards and infectious disease
outbreaks and their possible strategic management in Bangladesh under different scenarios. A set of statistical techniques were used to analyze the responses (n = 1590) from different social groups (healthcare professionals, academicians, students, Government
and NGO officials, and businessman) under three scenarios. The majority of the respondents agreed that the situation will become more devastating if there is another outbreak of diseases such as dengue, cholera, and diarrhoea. The lack of risk assessment and
communication, lack of sectoral coordination might restrict the contingency plan of the government. Therefore, considering the unprecedented worst cases a stringent strategic plan for emergency response, short term and long-term management should have to be
formulated. |
|
|
Rajter, JC, Sherman, et al |
Chest |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Ivermectin was shown to inhibit SARS-CoV-2 replication in-vitro, which has led to off-label use, but clinical efficacy
has not been previously described. Charts of 280 patients, 173 treated with ivermectin and 107 without ivermectin, were reviewed. Most patients in both groups also received hydroxychloroquine and/or azithromycin. Univariate analysis showed lower mortality
in the ivermectin group. Mortality was also lower among ivermectin-treated patients with severe pulmonary involvement. There were no significant differences in extubation rates or length of stay. After multivariate adjustment for confounders and mortality
risks, the mortality difference remained significant. Ivermectin treatment was associated with lower mortality during treatment of COVID-19, especially in patients with severe pulmonary involvement. Randomized controlled trials are needed to confirm these
findings. |
|
|
Ramazzotti, Daniele, Angaroni, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Phylogenomic approaches leverage accumulating genomic mutations to track the evolutionary history of the virus and
benefit from the surge of sequences deposited in public databases. We introduce VERSO (Viral Evolution ReconStructiOn), a new comprehensive framework for the characterization of viral evolution and transmission from sequencing data of viral genomes. Our probabilistic
approach first delivers robust phylogenetic models from clonal variant profiles and then exploits variant frequency patterns to characterize and visualize the intra-host genomic diversity of samples, which may reveal uncovered infection events. We prove via
extensive simulations that VERSO outperforms the state-of-the-art tools for phylogenetic inference, also in condition of noisy observations and sampling limitations. The application of our approach to 3960 SARS-CoV-2 samples from Amplicon sequencing and to
2766 samples from RNA-sequencing unravels robust phylogenomic models, improving the current knowledge on SARS-CoV-2 evolution and spread. Importantly, by exploiting co-occurrence patterns of minor variants, VERSO allows us to reveal uncovered infection paths,
which are validated with contact tracing data. VERSO is released as an open source tool at https://github.com/BIMIB-DISCo/VERSO. |
|
|
Rampotas, A, Pavord, et al |
J Clin Pathol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Thrombocytopenia is common in an intensive care unit (ICU) setting due to endogenous and iatrogenic factors. Despite
that, thrombocytopenia in patients with severe COVID-19 infections is surprisingly uncommon. By examining the blood film of 20 ICU patients with COVID-19, we observed the presence of platelet aggregates and macrothrombocytes indicating increased platelet activity.
We compared these findings with 20 blood films of non-severe COVID-19 cases where these findings were absent. These morphology features could be consistent with severe COVID-19 infection and is further evidence of the important role that platelets play when
COVID-19 manifests with thrombotic complications or respiratory failure. |
|
|
Raparelli, V, Palmieri, et al |
Biol Sex Differ |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A retrospective analysis was performed to assess if sex differences exist in the clinical manifestations and transitions
of care among hospitalized individuals dying with laboratory-confirmed SARS-CoV-2 infection in Italy (February 27-June 11, 2020). Clinical characteristics and the times from symptoms' onset to admission, nasopharyngeal swab, and death were compared between
sexes. Adjusted multivariate analysis was performed to identify the clinical features associated with male sex.
|
|
|
Rastaghi, Sedighe, Shark, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this study, we used the daily Hospitalization cases of COVID-19 of IRAN for the period of 15-May 2020 to 5-Oct 2020
which were obtained from the "Iran-COVID-19-Data1" database. Five distribution delay models were compared for estimating and forecasting. Results: based on measurement errors DDM selected as the best model for forecasting the number of death. According to
this model, the long-run effects show that observing the effect of hospitalization counts on death counts takes an average of five days and the overall hospitalized mortality rate was 12%. |
|
|
Ray, KN, Ettinger, et al |
Acad Pediatr |
Public Health response| Interventions de santé publique |
To identify unmet health and social resource needs during a county-wide COVID-19 stay-at-home order and phased re-opening
in Western Pennsylvania. we developed and fielded a weekly repeated cross-sectional electronic survey assessing usage of and unmet need for health and social service resources. Participants ranged from 229-1,001 per week. Unmet need for at least one health
or health-related social need resource varied by week, ranging from 55% (95% confidence interval (CI) 50-59%) of participants in week 2 to 43% (95% CI 37-49%) of participants in week 9 (p=0.006). Increased use of at least one resource ranged from 53% (95%
CI 47-58%) of participants in week 3 to 36% (95% CI 31-42%) in week 9 (p<0.001). Over half of families with children reported unmet health or social service needs during the first month of a county-wide COVID-19 stay-at-home order. |
|
|
Association between meteorological indicators and COVID-19 pandemic in Pakistan |
Raza, A, Khan, et al |
Environ Sci Pollut Res Int |
Epidemiology| Épidémiologie |
This study was designed to investigate the impact of meteorological indicators (temperature, rainfall, and humidity)
on total COVID-19 cases in Pakistan, its provinces, and administrative units from March 10, 2020, to August 25, 2020. The correlation analysis showed that COVID-19 cases and temperature showed a positive correlation. It implies that the increase in COVID-19
cases was reported due to an increase in the temperature in Pakistan, its provinces, and administrative units. The generalized Poisson regression showed that the rise in the expected log count of COVID-19 cases was 0.024 times for a 1 °C rise in the average
temperature in Pakistan. Second, the correlation between rainfall and COVID-19 cases was negative in Pakistan. However, the regression coefficient between the expected log count of COVID-19 cases and rainfall was insignificant in Pakistan. Third, the correlation
between humidity and the total COVID-19 cases was negative, which implies that the increase in humidity is beneficial to stop the transmission of COVID-19 in Pakistan, its provinces, and administrative units. |
|
Reynaga, E, Carrillo, et al |
Clin Microbiol Infect |
Clinical data| Données cliniques |
Data collection were prospectively defined and collected, with a follow-up of 4-5 weeks, including post-discharge,
at the Germans Trias i Pujol hospital between April 2nd and June 18th 2020. All patients received hydroxychloroquine as no guidelines at that time recommended the use of other treatments. At inclusion, patients had a medium risk of acute distress respiratory
syndrome (ADRS) according to the Berlin definition (Supplementary Table 2) and a mid to high NEWS score (Figure 1). All subjects had COVID-19 multilobar pneumonia and PaO2/FiO2 values ≤ 300 mmHg, requiring supplemental oxygen therapy. Our experience corroborates
the clinical applicability of IVIG for treating COVID-19 pneumonia, and warrants future randomized clinical trials to confirm these observations. |
|
|
Rieger, MO, He-Ulbricht, et al |
Data Brief |
Public Health response| Interventions de santé publique |
This data article describes the attitudes of German and Chinese respondents to some measures taken against the COVID-19
pandemic such as social distancing and face masks wearing, as well as their trust in government actions. The data were collected through six online surveys conducted between March 23 to September 15 2020 from 865 participants in Germany, 135 in China and 169
participants with Chinese roots in Germany. The data were partly used in related research papers in which the theoretical background, analysis of the survey variables and the interpretation of the findings are presented in detail 3, 4, 5]. These survey data
can be used in future studies of individual perception of the measures taken in the fight against the pandemic. The data cover topics which include, in particular, worries about the pandemic, estimations and expectations concerning the further development
of the pandemic, perception of government responses and media coverage, attitudes towards social distancing and other countermeasures, and COVID-19-related conspiracy theories. Differences between Chinese and German respondents on some of these issues can
also be studied with this dataset. |
|
|
Angiogenesis, hereditary hemorrhagic telangiectasia and COVID-19 |
Riera-Mestre, A, Iriarte, et al |
Angiogenesis |
Clinical data| Données cliniques |
We aimed to know the prevalence of coronavirus disease 2019 (COVID-19) in hereditary hemorrhagic telangiectasia (HHT)
patients. The HHT pathogenic angiogenesis and endothelial injury in COVID-19 are discussed using data from RiHHTa (Computerized Registry of Hereditary Hemorrhagic Telangiectasia) registry. RiHHTa is an open, multicenter, prospective, observational registry
including adult patients with HHT. A 27-item survey that captured clinical data of admitted HHT patients for COVID-19 was distributed to all RiHHTa investigators from June 8th to June 24th 2020. Only one out of 1177 HHT patients was admitted for COVID-19 pneumonia.
She is a 74 years-old woman with a pathogenic variant in ACVRL1 gene. Her clinical course did not involve mechanical ventilation or worsening epistaxis, and she was successfully discharged after two weeks. The endothelial damage and the consequent angiogenic
process in COVID-19 patients deserve further investigation. |
|
Rodriguez-Leor, O, Cid-Álvarez, et al |
Rev Esp Cardiol |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to assess changes in ST-segment elevation myocardial infarction (STEMI) management during
the COVID-19 outbreak. Using a multicenter, nationwide, retrospective, observational registry of consecutive patients who were managed in 75 specific STEMI care centers in Spain, we compared patient and procedural characteristics and in-hospital outcomes in
2 different cohorts with 30-day follow-up according to whether the patients had been treated before or after COVID-19. The number of STEMI patients treated during the current COVID-19 outbreak fell vs the previous year and there was an increase in the median
time from symptom onset to reperfusion and a significant 2-fold increase in the rate of in-hospital mortality. No changes in reperfusion strategy were detected, with primary percutaneous coronary intervention performed for the vast majority of patients. The
co-existence of STEMI and SARS-CoV-2 infection was relatively infrequent. |
|
|
Rodríguez-Molinero, A, Gálvez-Barrón, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to analyze the relationship between the prognosis of COVID-19 and the form of presentation
of the disease, the previous pathologies of patients and their chronic treatments. This was an observational study on a cohort of 418 patients admitted to three regional hospitals in Catalonia (Spain). As primary outcomes, severe disease (need for oxygen therapy
via nonrebreather mask or mechanical ventilation) and death were studied. Advanced age, male sex and obesity were independent markers of poor prognosis. The most frequent presenting symptom was fever, while dyspnea was associated with severe disease and the
presence of cough with greater survival. This study identified the most robust markers of poor prognosis for COVID-19. These results can help to correctly stratify patients at the beginning of hospitalization based on the risk of developing severe disease. |
|
|
Román-Mata, SS, Zurita-Ortega, et al |
J Clin Med |
Public Health response| Interventions de santé publique |
The aim of the present study was to describe the resilience levels in a Spanish population during the Coronavirus (COVID-19)
pandemic and to analyze the existing associations between high resilience and socio-demographic, work, and academic parameters. Slightly more than a quarter of the participants showed low resilience, almost half reported moderate resilience, and slightly more
than a quarter had high resilience. Those who were employed were 2.16-times more likely to have high resilience, whilst those with higher education were 1.57-times more likely. Those working in emergency services were 1.66-times more likely, and those with
dependents were 1.58-times more likely to have high resilience. |
|
|
Rosenman, KD, Reilly, et al |
Public Health Rep |
Public Health response| Interventions de santé publique |
For the 3-month period from January 1 to March 30, 2020, the number of calls about exposure to cleaners and disinfectants
made to US poison centers in all states increased 20.4%, and the number of calls about exposure to disinfectants increased 16.4%. We examined calls about cleaners and disinfectants to the Michigan Poison Center (MiPC) since the onset of the COVID-19 pandemic.
We compared all calls related to exposure to cleaners or disinfectants, calls with symptoms, and calls in which a health care provider was seen during the first quarters of 2019 and 2020 and in relationship to key COVID-19 dates. From 2019 to 2020, the number
of all disinfectant calls increased by 42.8%, the number of calls with symptoms increased by 57.3%, the average number of calls per day doubled after the first Michigan COVID-19 case, from 4.8 to 9.0, and the proportion of calls about disinfectants among all
exposure calls to the MiPC increased from 3.5% to 5.0% (P < .001). Calls for exposure to cleaners did not increase significantly. Exposure occurred at home for 94.8%97.1% of calls, and ingestion was the exposure route for 59.7% of calls. |
|
|
Asthma Is Associated with Increased Risk of Intubation but Not Hospitalization
or Death in COVID-19 |
Rosenthal, JA, Awan, et al |
Ann Allergy Asthma Immunol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective study, 787 patients were identified by an electronic medical record (EMR) search of positive
SARS-CoV2 PCR between March and May 2020. Patients with underlying lung disease other than asthma were excluded. Demographics, clinical history, and laboratory markers (trough white blood cell, platelet, and lymphocyte counts, as well as peak d-dimer, ferritin,
c-reactive protein (CRP), lactate dehydrogenase (LDH), and interleukin-6 (IL-6) levels) were collected. The odds of intubation was two-fold higher among asthmatics compared to non-asthmatics (OR 2; 95% CI: 1 fold, 4 fold; p = 0.047). However, there was no
significant difference in duration of intubation (p = 0.44) or hospitalization (p = 0.44). In conclusion, there was no association between asthma and risk of hospitalization, ICU admission, or death among patients with COVID-19. Asthma was associated with
increased odds of intubation, but not duration of intubation or hospitalization. This study adds to the growing literature that patients with asthma may not be at higher risk of severe outcomes with COVID-19. |
|
Rotimi, O, Beatson, et al |
Ann Med Surg (Lond) |
Healthcare Response | Réponse des soins de santé |
Closed-loop audit of consent forms for patients undergoing emergency and elective surgical procedures. Interventions
implemented included education of wider surgical teams. Data was collected during a one-week period for each cycle and analysed using Chi-squared test. In cycle 1, 6/17 (35.3%) case notes documented discussion of COVID-19 risk. Following intervention, compliance
improved to 23/29 (79.3%) cases in cycle 2 and 33/45 (73.3%) cases in cycle 3. Pre-intervention, our consenting practice was non-compliant. Our interventions led to significant and sustained improvements in practice. We recommend provision of wider surgical
team education to facilitate good consenting practice. |
|
|
Rovas, A, Osiaevi, et al |
Angiogenesis |
Clinical data| Données cliniques Immunology | Immunologie |
To comprehensively characterize and quantify microvascular alterations in patients with COVID-19. Hospitalized adult
patients with moderate-to-severe or critical COVID-19 (n = 23) were enrolled non-consecutively in this prospective, observational, cross-sectional, multi-center study. Fifteen healthy volunteers served as controls. All participants underwent intravital microscopy
by sidestream dark field imaging to quantify vascular density, red blood cell velocity (V(RBC)), and glycocalyx dimensions (perfused boundary region, PBR) in sublingual microvessels. Circulating levels of endothelial and glycocalyx-associated markers were
measured by multiplex proximity extension assay and enzyme-linked immunosorbent assay. Our data clearly show severe alterations of the microcirculation and the endothelial glycocalyx in patients with COVID-19. Future therapeutic approaches should consider
the importance of systemic vascular involvement in COVID-19. |
|
|
Rovere-Querini, P, Tresoldi, et al |
Panminerva Med |
Clinical data| Données cliniques |
Biobanks are imperative infrastructures, particularly during outbreaks, when there is an obligation to acquire and
share knowledge as quick as possible to allow for implementation of science-based preventive, diagnostic, prognostic and therapeutic strategies. We established a COVID-19 biobank with the aim of collecting high-quality and well-annotated human biospecimens,
in the effort to understand the pathogenic mechanisms underlying COVID-19 and identify therapeutic targets (COVID-BioB, NCT04318366). A total of 46,677 samples have been collected from 913 participants (63.3% males, median [IQR] age 62.2 [51.2 - 74.0] years)
since the beginning of the program. Most patients (66.9%) had been admitted to hospital for COVID-19, with a median length of stay of 15.0 (9.0 - 27.0) days. A minority of patients (13.3% of the total) had been admitted for other reasons and subsequently tested
positive for SARS-CoV-2. |
|
|
Ruiz-Frutos, C, Ortega-Moreno, et al |
Saf Sci |
Public Health response| Interventions de santé publique |
The interrelationship between the sense of coherence, work environment, work engagement, and psychological distress
have particular interest in non-health workers who carried out essential activities during the COVID-19 pandemic. 1089 questionnaires have been analysed. Engagement (UWES-9), sense of coherence (SOC-13), mental health (Goldberg GHQ-12), demographic data, perception
of health and stress and work environment were assessed. At low levels of engagement, the percentage of distress is higher (77.9%). The 94.1% believe it necessary for professionals and volunteers involved in COVID-19 to receive psychological support. Almost
all respondents believed that professionals and volunteers involved in COVID-19 should receive psychological support. This may be an indicator of the effect of the COVID-19 pandemic on workers’ mental health. |
|
|
Rut, W, Lv, et al |
Sci Adv |
Coronavirology| Coronavirologie |
We used a combinatorial substrate library and performed comprehensive activity profiling of SARS-CoV-2 PLpro. On the
scaffold of the best hits from positional scanning, we designed optimal fluorogenic substrates and irreversible inhibitors with a high degree of selectivity for SARS PLpro. We determined crystal structures of two of these inhibitors in complex with SARS-CoV-2
PLpro that reveals their inhibitory mechanisms and provides a molecular basis for the observed substrate specificity profiles. Last, we demonstrate that SARS-CoV-2 PLpro harbors deISGylating activity similar to SARSCoV-1 PLpro but its ability to hydrolyze
K48-linked Ub chains is diminished, which our sequence and structure analysis provides a basis for. Together, this work has revealed the molecular rules governing PLpro substrate specificity and provides a framework for development of inhibitors with potential
therapeutic value or drug repurposing. |
|
|
Evaluation of Three SARS CoV-2 IgG Antibody Assays and Correlation with Neutralizing
Antibodies |
Rychert, J, Couturier, et al |
J Appl Lab Med |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We evaluated three commonly used SARS-CoV-2 IgG assays (Abbott, DiaSorin and EUROIMMUN) for clinical sensitivity, specificity,
and correlation with neutralizing antibodies and then compared antibody kinetics during the acute phase of infection. Clinical sensitivity was 91.43% for Abbott, and 88.57% for both DiaSorin and EUROIMMUN. Clinical specificity was 99.00% for Abbott and DiaSorin
and 94.00% for EUROIMMUN. The IgG assays demonstrated good qualitative agreement (minimum of 94%) and good correlation between the quantitative result for each combination of assays (r2≥0.90). The three IgG antibody assays demonstrated comparable performance
characteristics. Importantly, a qualitative positive IgG result obtained with any of the assays was associated with the presence of neutralizing antibodies; however, neutralizing antibody concentrations did not correlate well with signal to cutoff ratios. |
|
Rzadkowski, Grzegorz |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In the present paper, we model the cumulative number of persons reported to be infected by the SARS-CoV-2 virus, in
a country or a region, by a sum of logistic functions. For a given logistic function, using Eulerian numbers, we find the zeros of its successive derivatives and their relationship with the saturation level of this function. In a given time series, having
potentially the logistic trend, we use its second differences to determine points corresponding to these zeros. To estimate the parameters of the approximating logistic function, we define and use logistic wavelets. Then we apply the theory to the cases of
SARS-CoV-2 infections in the United States and the United Kingdom. |
|
|
Reduced Admissions for Cerebrovascular Events During COVID-19 Outbreak in Italy |
Sacco, S, Ricci, et al |
Stroke |
Healthcare Response | Réponse des soins de santé |
We aimed to investigate the rate of hospital admissions for cerebrovascular events and of revascularization treatments
for acute ischemic stroke in Italy during the coronavirus disease 2019 (COVID-19) outbreak. Ischemic strokes decreased from 2399 in 2019 to 1810 in 2020, with a corresponding hospitalization rate ratio (RR) of 0.75 (95% CI, 0.71-0.80] P<0.001); intracerebral
hemorrhages decreased from 400 to 322 (hospitalization RR, 0.81 95% CI, 0.69-0.93]; P=0.004), and transient ischemic attacks decreased from 322 to 196 (hospitalization RR, 0.61 95% CI, 0.51-0.73]; P<0.001). Hospitalizations decreased in Northern, Central,
and Southern Italy. Intravenous thrombolyses decreased from 531 (22.1%) in 2019 to 345 in 2020 (19.1%; RR, 0.86 95% CI, 0.75-0.99]; P=0.032), while primary endovascular procedures increased in Northern Italy (RR, 1.61 95% CI, 1.13-2.32]; P=0.008). We found
no correlation (P=0.517) between the hospitalization RRs for all strokes or transient ischemic attack and COVID-19 incidence in the different areas. |
|
Sadhu, AR, Serrano, et al |
J Diabetes Sci Technol |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We performed a feasibility pilot study using continuous glucose monitoring (CGM) in critically ill patients with COVID-19
in the intensive care unit (ICU). Single-center, retrospective study of glucose monitoring in critically ill patients with COVID-19 on insulin therapy using Medtronic Guardian Connect and Dexcom G6 CGM systems. Primary outcomes were feasibility and accuracy
for trending POC-BG. CGM devices were placed on 11 patients: Medtronic (n = 6) and Dexcom G6 (n = 5). Both systems were feasible and reliable with good nurse acceptance. To determine accuracy, 437 paired SG and POC-BG readings were analyzed. For Medtronic,
the MARD was 13.1% with 100% of readings in zones A and B on Clarke EGA. For Dexcom, MARD was 11.1% with 98% of readings in zones A and B. B&A plots had a mean bias of -17.76 mg/dL (Medtronic) and -1.94 mg/dL (Dexcom), with wide 95% limits of agreement. |
|
|
Saeed, Ghufran, Gaba, et al |
medRxiv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Our aim is to correlate the clinical condition of patients with COVID-19 infection with the 25 Point CT severity score
by Chang et al (devised for assessment of ARDS in patients with SARS in 2005). Data of consecutive symptomatic patients who were suspected to have COVID-19 infection and presented to our hospital, was collected from March to April 2020. All patients underwent
two consecutive RT-PCR tests and had a non-contrast HRCT scan done at presentation. From the original cohort of 1062 patients, 160 patients were excluded leaving a total number of 902 patients. The mean age was 44.2 +/- 11.9 years [85.3%males, 14.7 %females].
CT severity score found to be positively correlated with lymphopenia, increased serum CRP, d-dimer and ferritin levels (p < 0.0001). The oxygen requirements as well as length of hospital stay were increasing with the increase of scan severity. |
|
|
Said, RM, El-Shafei, et al |
Environ Sci Pollut Res Int |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to assess occupational stress, job satisfaction, and intent to leave among nurses dealing
with suspected COVID-19 patients. A comparative cross-sectional study was conducted among 210 nurses from Zagazig Fever Hospital (ZFH) which is one of COVID-19 Triage Hospitals (Group I) versus 210 nurses from Zagazig General Hospital (ZGH) (Group II) which
is neither triage nor isolation hospital; dealing only with suspected COVID-19 patients in emergency at Sharkia Governorate, Egypt, from 10th to 24th of April 2020. Three quarters of nurses (75.2%) in ZFH had high stress level versus 60.5% in ZGH. Workload
(98.6%), dealing with death and dying (96.7%), personal demands and fears (95.7%), employing strict biosecurity measures (95.2%), and stigma (90.5%) represented the highest priority stressors in ZFH, while exposure to infection risk (97.6%) was the stressor
of highest priority among ZGH according to Pareto analysis. More than half of nurses (51.0%) in ZFH reported low satisfaction level versus 41.9% in ZGH. Only 4.8% of nurses in ZFH definitely had no intent to leave their present job. Type of hospital and its
related workload were the most significant predictor of all the studied outcomes. |
|
|
Saiman, L, Acker, et al |
Semin Perinatol |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
We present our IP&C policies and procedures for the obstetrical population developed from mid-March to mid-May 2020
when New York City served as the epicenter of the pandemic in the U.S. For patients, we describe screening for COVID-19, testing for SARS-CoV-2, and clearing patients from COVID-19 precautions. For staff, we address self-monitoring for symptoms, PPE in different
clinical scenarios, and reducing staff exposures to SARS-CoV-2. For visitors/support persons, we address limiting them in labor and delivery, the postpartum units, and the NICU to promote staff and patient safety. We describe management of SARS-CoV-2-positive
mothers and their newborns in both the well-baby nursery and in the neonatal ICU. Newborns of SARS-CoV-2-positive mothers are considered persons under investigation (PUIs) until 14 days of life, the duration of the incubation period for SARS-CoV-2. |
|
|
Saini, Sunil Kumar, Hersby, et al |
bioRxiv |
Coronavirology| Coronavirologie Immunology | Immunologie |
To understand the CD8+ T cell immunity related to viral protection and disease severity in COVID-19, we evaluated the
complete SARS-CoV-2 genome (3141 MHC-I binding peptides) to identify immunogenic T cell epitopes, and determine the level of CD8+ T cell involvement using DNA-barcoded peptide-major histocompatibility complex (pMHC) multimers. COVID-19 patients showed strong
T cell responses, with up to 25% of all CD8+ lymphocytes specific to SARS-CoV-2-derived immunodominant epitopes, derived from ORF1 (open reading frame 1), ORF3, and Nucleocapsid (N) protein. A strong signature of T cell activation was observed in COVID-19
patients, while no T cell activation was seen in the 'non-exposed' and 'high exposure risk' healthy donors. Interestingly, patients with severe disease displayed the largest T cell populations with a strong activation profile. These results will have important
implications for understanding the T cell immunity to SARS-CoV-2 infection, and how T cell immunity might influence disease development. |
|
|
Salazar, E, Christensen, et al |
Am J Pathol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We are conducting a prospective, propensity score-matched study assessing the efficacy of COVID-19 convalescent plasma
transfusion versus standard of care as treatment for severe and/or critical COVID-19. We present herein the results of an interim analysis of 316 patients enrolled at Houston Methodist hospitals from March 28 to July 6, 2020. Of the 316 transfused patients,
136 met a 28-day outcome and were matched to 251 non-transfused control COVID-19 patients. Matching criteria included age, sex, body mass index, comorbidities, and baseline ventilation requirement 48 hours from admission, and in a second matching analysis,
ventilation status at day 0. Variability in the timing of transfusion relative to admission and titer of antibodies of plasma transfused allowed for analysis in specific matched cohorts. The analysis showed a significant reduction (P = 0.047) in mortality
within 28 days, specifically in patients transfused within 72 hours of admission with plasma with an anti-spike protein receptor binding domain titer of ≥1:1350. These data suggest that treatment of COVID-19 with high anti-receptor binding domain IgG titer
convalescent plasma is efficacious in early-disease patients. |
|
|
Salehi, PP, Torabi, et al |
Facial Plast Surg Aesthet Med |
Healthcare Response | Réponse des soins de santé |
The objectives of this study among facial plastic and reconstructive surgeons (FPRS), include (1) quantifying the use
of telemedicine, (2) examining the impact of novel coronavirus-19 (COVID-19) on telemedicine practices, (3) highlighting the types of telemedicine employed, (4) anticipating how telemedicine will be utilized in the future, and (5) describing FPRS' attitudes
and understanding of telemedicine technologies. Overall, out of 100 responses, 91% of responders utilize telemedicine, of which 76.9% began during the COVID-19 pandemic. Of those that utilize telemedicine, the two biggest concerns were difficulties with physical
examination (69.2%) and lack of human connection (44%). 75.8% of telemedicine utilizers plan to incorporate telemedicine into their practice moving forward. Of all responders, 71% believed that telemedicine will have a positive effect on the field of FPRS.
The COVID-19 pandemic has accelerated the adoption of telemedicine among FPRS in the United States. The great majority of responders plan to incorporate telemedicine into their practice even after the pandemic subsides and believe that telemedicine will have
a net positive effect on the field of FPRS. |
|
|
Effects of demographic and weather parameters on COVID-19 basic reproduction number |
Salom, Igor, Rodic, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We here apply a novel approach, exploiting widespread growth regimes in COVID-19 detected case counts. By applying
nonlinear dynamics methods to the exponential regime, we extract basic reproductive number R0 (i.e., the measure of COVID-19 inherent biological transmissibility), applying to the completely naive population in the absence of social distancing, for 118 different
countries. In addition to some of the already reported tendencies, we show a number of both novel results and those that help settle existing disputes: the absence of dependence on wind speed and air pressure, negative correlation with precipitation; significant
positive correlation with society development level (human development index) irrespective of testing policies, and percent of the urban population, but an absence of correlation with population density per se. We find a strong positive correlation of transmissibility
on alcohol consumption, and the absence of correlation on refugee numbers, contrary to some widespread beliefs. Significant tendencies with health-related factors are reported, including a detailed analysis of the blood type group showing consistent tendencies
on Rh factor, and a strong positive correlation of transmissibility with cholesterol levels. |
|
Samimagham, HR, Hassani Azad, et al |
Trials |
RCT |
This study aims to investigate the effect of Famotidine on the recovery process of COVID-19 patients. This phase III
randomized clinical trial was designed with two parallel arms, placebo-controlled, single-blind, and concealed allocation. Intervention group receives standard pharmacotherapy according to the treatment protocols of the National Committee of COVID-19 and oral
famotidine 160 mg (Manufactured by Chemidarou Pharmaceutical Company) four times a day until the day of discharge, for a maximum of fourteen days. Comparator group receives standard drug therapy according to the treatment protocols of the National Committee
of COVID-19 and placebo in the same dosage. Patients’ temperature, respiration rate, oxygen saturation, lung infiltration, lactate dehydrogenase and complete blood count were measured at the baseline (before the intervention) and on day 14 after the intervention
or on the discharge day. |
|
|
Santhosh, J, Al Salmani, et al |
Int J Gynaecol Obstet |
Clinical data| Données cliniques |
This retrospective descriptive study aims to describe maternal and neonatal outcomes in pregnant women presenting with
COVID-19 at a tertiary care center in Muscat, Oman. Additionally, the present study highlights the specific clinical features and management of COVID-19 in this part of the world. |
|
|
PMC7553070; Electricity demand during pandemic times: The case of the COVID-19
in Spain |
Santiago, I, Moreno-Munoz, et al |
Energy Policy |
Public Health response| Interventions de santé publique |
A detailed analysis of how confinement measures have modified the electricity consumption in Spain, one of the countries
most affected by this pandemic, has been performed in this work. Its electricity consumption has decreased by 13.49% from March 14 to April 30, compared to the average value of five previous years. Daily power demand profiles, especially morning and evening
peaks, have been modified at homes, hospitals, and in the total power demand. These changes generate a greater uncertainty for the System Operator when making demand forecasts, but production deviations have increased by only 0.1%, thanks to the presence of
a diversified generation mix, which has been modified during this period, increasing the proportion of renewable sources and decreasing CO(2) emissions. |
|
Santiago-Frangos, Andrew, Nemudryi, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
To combat viral pandemics, there is an urgent need for inexpensive new technologies that enable fast, reliable, and
scalable detection of viruses. Here we repurposed the type III CRISPR-Cas system for sensitive and sequence specific detection of SARS-CoV-2 in an assay that can be performed in one hour or less. RNA recognition by type III systems triggers Cas10-mediated
polymerase activity, which simultaneously generates pyrophosphates, protons and cyclic oligonucleotides. We show that amplified products of the Cas10-polymerase are detectable using colorimetric or fluorometric readouts. |
|
|
Saravanan, KM, Zhang, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study, we used molecular docking to screen 41 reported antiviral compounds that exist in Indian medicinal plants
and shown amentoflavone from the plant Torreyanucifera with a higher docking score. Furthermore, we performed a 40 ns atomic molecular dynamics simulation and free binding energy calculations to explore the stability of the top five protein-ligand complexes.
Through the article, we insist that the amentoflavone, hypericin and Torvoside H from the traditional Indian medicinal plants may be used as a potential inhibitor of SARS-CoV2 main protease and further biochemical experiments could shed light on understanding
the mechanism of inhibition by these plant-derived antiviral compounds. |
|
|
Saurabh, S, Verma, et al |
JMIR Public Health Surveill |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
The aim of this study was to estimate the serial interval and basic reproduction number (R(0)) to understand the transmission
dynamics of the COVID-19 outbreak at a district level. We used standard mathematical modeling approaches to assess the utility of these factors in determining the effectiveness of COVID-19 responses and projecting the size of the epidemic. Contact tracing
of individuals infected with SARS-CoV-2 was performed to obtain the serial intervals. The median and 95th percentile values of the SARS-CoV-2 serial interval were obtained from the best fits with the weibull, log-normal, log-logistic, gamma, and generalized
gamma distributions. Aggregate and instantaneous R(0) values were derived with different methods using the EarlyR and EpiEstim packages in R software.The projected transmission reductions indicate that strengthening control measures could lead to proportionate
reductions of the size of the COVID-19 epidemic. Time-dependent instantaneous R(0) estimation based on the process by Jombart et al was found to be better suited for guiding COVID-19 response at the district level than overall R(0) or instantaneous R(0) estimation
by the Wallinga and Teunis method. |
|
|
Schiavone, M, Gasperetti, et al |
J Clin Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, consecutive COVID-19 patients admitted to four different institutions were screened for enrolment. Patients
were divided into two groups (chronic coronary syndromes CCS vs. no-CCS). A total of 674 COVID-19 patients were enrolled, 112 (16.6%) with an established history of CCS. Myocardial injury occurred in 43.8% patients with CCS vs. 14.4% patients without CCS,
as confirmed by high-sensitivity cardiac troponin (hs-cTn) elevation on admission or during hospitalization. The mortality rate in the CCS cohort was nearly three-fold higher. After adjusting for disease severity, myocardial injury resulted significantly associated
with in-hospital mortality in the no-CCS group but not in CCS patients. |
|
|
Schwarzkopf, S, Krawczyk, et al |
Emerg Infect Dis |
Clinical data| Données cliniques Immunology | Immunologie |
We investigated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among a group
of convalescent, potential blood donors in Germany who had PCR-confirmed SARS-CoV-2 infection. Sixty days after onset of symptoms, 13/78 (17%) study participants had borderline or negative results to an ELISA detecting IgG against the S1 protein of SARS-CoV-2.
We analyzed participants with PCR-confirmed infection who had strong antibody responses (ratio >3) as positive controls and participants without symptoms of SARS-CoV-2 infection and without household contact with infected patients as negative controls. Using
interferon-γ ELISpot, we observed that 78% of PCR-positive volunteers with undetectable antibodies showed T cell immunity against SARS-CoV-2. We observed a similar frequency (80%) of T-cell immunity in convalescent donors with strong antibody responses but
did not detect immunity in negative controls. We concluded that, in convalescent patients with undetectable SARS-CoV-2 IgG, immunity may be mediated through T cells. |
|
|
Excess mortality during the COVID-19 outbreak in Italy: a two-stage interrupted time-series
analysis |
Scortichini, M, Schneider Dos Santos, et al |
Int J Epidemiol |
Epidemiology| Épidémiologie |
This study presents an analysis of the excess mortality across the 107 Italian provinces, stratified by sex, age group
and period of the outbreak. In the period 15 February–15 May 2020, we estimated an excess of 47 490 [95% empirical confidence intervals (eCIs): 43 984 to 50 362] deaths in Italy, corresponding to an increase of 29.5% (95% eCI: 26.8 to 31.9%) from the expected
mortality. |
|
Women's mental health: acute impact of COVID-19 pandemic on domestic violence |
Sediri, S, Zgueb, et al |
Arch Womens Ment Health |
Public Health response| Interventions de santé publique |
This study aims to assess the effect of the COVID-19-related lockdown on Tunisian women’s mental health and gender-based
violence. An online survey was conducted, we chose a female-exclusive social group on Facebook and used the snowball sampling method. A total of 751 participants originating from all the Tunisian regions completed the questionnaire. More than half of the participants
(57.3%) reported extremely severe distress symptoms. Psychological abuse was the most frequent type of violence (96%). Women who had experienced abuse before the lockdown were at an increased risk of violence during lockdown. |
|
Sepay, N, Sekar, et al |
J Mol Struct |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In the COVID-19 pandemic, natural products (NPs) can be used or can help to find new compound against it. More than
fifty NPs were screened for the target and one terpenoid (T3) from marine sponge Cacospongia mycofijiensis shows excellent SARS CoV-2 Mpro inhibitory activity in comparison with known peptide based inhibitors. Considering binding affinity, bioavailability,
pharmacokinetics and toxicity of the compounds, it is proposed that the NP T3 can act as a potential drug candidate against COVID-19 virus. |
|
|
Setiawaty, V, Kosasih, et al |
Am J Trop Med Hyg |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques Coronavirology|
Coronavirologie |
We describe the first 11 detected COVID-19 cases in Indonesia, resulting from a local transmission occurring in a club
and a restaurant. The virus was detected until an average of 21.3 days (range: 11–25, SD: 4.1) after the onset of illness, and the partial N gene sequences (28,321–28,707 nucleotide position) had 100% similarity with the SARS-CoV-2 sequence from Wuhan. Two
subjects were asymptomatic, and one subject has died. |
|
|
The Safety of Contemporary Planned Cancer Surgery
During the COVID-19 Pandemic |
Shackley, David, Gray, et al |
medRxiv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The aim of this audit was to assess if the planned surgical cancer care (both diagnostic for possible cancer, and treatment
of known cancer) during this period of widespread community and hospital based COVID-19 infection resulted in patients acquiring symptomatic COVID-19 as a consequence of their surgical admission, and if so, what the impact on patients was. The use of peri
operative COVID-19 infection prevention strategies has allowed for the safe continuation of elective cancer surgery during this pandemic in all surgical units, without significant additional COVID-19 related morbidity or mortality. |
|
Shaikh, A, Zeldis, et al |
Clin J Am Soc Nephrol |
Clinical data| Données cliniques |
We describe a case series of patients on maintenance hemodialysis (HD) at a single dialysis center in New York, in
whom serial SARS-CoV-2 RNA and IgG antibody testing was performed. Whether patients on maintenance HD develop antibodies in response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is not well documented. Additionally, the duration
of SARS-CoV-2 viral RNA shedding among patients on maintenance HD with COVID-19 has not been extensively studied. |
|
|
Shan, S, Guangming, et al |
Rev Inst Med Trop Sao Paulo |
Clinical data| Données cliniques |
67-year-old male with COVID-19 and a 5-year history of hypertension and no other underlying diseases. |
|
|
Shariati, M, Mesgari, et al |
J Environ Health Sci Eng |
Epidemiology| Épidémiologie |
In this study, the cumulative incidence rate (CIR) and cumulative mortality rate (CMR) of all countries affected by
the new corona outbreak were calculated at the end of March and April, 2020. San Marino and Italy revealed the highest CMR by the end of March, though Belgium took the place of Italy as of 30th April. At the end of the research period (by 30th April), the
CIR showed obvious spatial clustering. In conclusion, hot spot analysis coupled with Anselin local Moran’s I provides a scrupulous and objective approach to determine the locations of statistically significant clusters of COVID-19 cases shedding light on the
high-risk districts. |
|
|
PMC7550045; Reversible Myocardial Injury Associated with SARS-CoV-2 in an Infant |
Sharma, M, Gorstein, et al |
JACC Case Rep |
Clinical data| Données cliniques |
Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and
has been associated with myocardial dysfunction and heart failure in adult patients. We report a case of reversible myocardial injury and heart failure in an infant with SARS-CoV-2 infection. |
|
PMC7550272; Microthrombi on Skin Biopsy in a Patient with COVID-19 |
Shehi, E, Chilimuri, et al |
JAAD Case Rep |
Clinical data| Données cliniques |
We present the case of a COVID-19 positive patient with maculopapular rash whose skin biopsy showed the presence of
fibrin microthrombi within the small vessels as the main distinctive histologic feature. |
|
Sherif, M |
J Behav Exp Finance |
Economics | Économie |
This paper examines the rapid spread of Coronavirus (COVID-19) and its short-term impact on the Shariah-compliant UK
Dow Jones market index to capture the dynamic behavior of stock returns at economy and industry levels. Using daily data over the period January 20 to May 20 and ten UK industrial sector groupings, the findings suggest a strong and statistically significant
relationship between the COVID-19 pandemic and the performance of the conventional stock market index. |
|
|
Sherman, AmyC, Babiker, et al |
medRxiv |
Public health interventions*| Interventions de santé publique |
To assess the impact of the SARS-CoV-2 pandemic on seasonal respiratory viruses, absolute case counts and viral reproductive
rates from 2019-2020 were compared against previous seasons. Our findings suggest that the public health measures implemented to reduce SARS-CoV-2 transmission significantly reduced the transmission of other respiratory viruses. |
|
|
Shevlin, M, McBride, et al |
BJPsych Open |
Public Health response| Interventions de santé publique |
We investigated the prevalence of COVID-19-related anxiety, generalised anxiety, depression and trauma symptoms in
the UK population during an early phase of the pandemic, and estimated associations with variables likely to influence these symptoms. This study showed a modest increase in the prevalence of mental health problems in the early stages of the pandemic, and
these problems were predicted by several specific COVID-related variables. |
|
|
Shi, Lei, Huang, et al |
medRxiv |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
We assess the safety and efficacy of human umbilical cord-derived MSCs (UC-MSCs) for severe COVID-19 patients with
lung damage. 100 patients were finally recruited to receive either UC-MSCs (n = 65) or placebo (n = 35). UC-MSCs treatment is a safe and potentially effective therapeutic approach for COVID-19 patients with lung damage. A phase 3 trial is required to evaluate
effects on reducing mortality and preventing long-term pulmonary disability. |
|
|
Shiers, S, Ray, et al |
Pain |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
We show that human dorsal root ganglion (DRG) neurons express the SARS-CoV-2 receptor, angiotensin-converting enzyme
2 at the RNA and protein level. We also demonstrate that SARS-CoV-2 and coronavirus-associated factors and receptors are broadly expressed in human DRG at the lumbar and thoracic level as assessed by bulk RNA sequencing. Therefore, DRG sensory neurons are
a potential target for SARS-CoV-2 invasion of the peripheral nervous system, and viral infection of human nociceptors may cause some of the persistent neurological effects seen in COVID-19. |
|
|
Shoer, S, Karady, et al |
Med (N Y) |
Modelling/ prediction| Modélisation/prédiction Clinical data| Données cliniques |
We devised a model estimating the probability of an individual to test positive for COVID-19 based on answers to 9
simple questions that have been associated with COVID-19 infection. Our model was devised from a subsample of a national symptom survey that was answered over 2 million times in Israel in its first 2 months. Our analyses revealed interactions between several
symptoms and age, suggesting variation in the clinical manifestation of the disease in different age groups. |
|
|
Shrestha, N, Shad, et al |
One Health |
Epidemiology| Épidémiologie Economics | Économie |
This paper aims to examine the potential impacts of COVID-19 on globalization and global health in terms of mobility,
trade, travel, and countries most impacted. In Africa, more vulnerable countries include South Africa and Egypt; in Europe, they are Russia, Germany, and Italy; in Asia and Oceania, they are India, Iran, Pakistan, Saudi Arabia, and Turkey; and for the Americas,
they are Brazil, USA, Chile, Mexico, and Peru. The impact on mobility, economy, and healthcare systems has only started to manifest. |
|
|
Shrestha, Roshana, Siwakoti, et al |
medRxiv |
Public Health response| Interventions de santé publique |
The aim of this study was to provide an overview of the impact of the COVID-19 pandemic on the occurrence and clinical
profile of suicide and SH in our ED. We found an increase in patients presenting with suicide and SH in our ED during the pandemic which is likely to reflect an increased prevalence of mental illness in the community. |
|
|
Shui, TJ, Li, et al |
BMC Infect Dis |
Clinical data| Données cliniques |
The clinical characteristics, reverse transcriptase-polymerase chain reaction (RT-PCR) results from throat swab specimens
and the results of serological COVID-19 rapid diagnostic test (RDT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were retrospectively reviewed in Wuhan, China. Some patients who had been quarantined and had subsequently recovered from COVID-19
had recurrent positive RT-PCR results for SARS-CoV-2, and the possibility of transmission of the virus by recovered patients needs further investigation. |
|
|
Rapid deployment of a telemedicine care model for genetics and metabolism during COVID-19 |
Shur, N, Atabaki, et al |
Am J Med Genet A |
Healthcare Response | Réponse des soins de santé |
Prior to the 2020 pandemic the Division of Genetics and Metabolism piloted a telemedicine program focused on initial
and follow‐up visits in the patients' home. At the onset of the COVID‐19 pandemic, this pilot‐program was deployed by the full team of 22 providers in one business day. This model optimized patient safety and workforce preservation while providing full access
to patients during a pandemic. We provide initial data on visit numbers, types of diagnoses, and no‐show rates. |
|
Siewe Fodjo, JN, Villela, et al |
J Acquir Immune Defic Syndr |
Clinical data| Données cliniques Public Health response| Interventions de santé publique |
We surveyed people living with HIV (PLWH) in different countries to investigate whether their medical follow-up and
psychosocial well-being had been compromised due to COVID-19 and associated restrictions. Three hundred seventeen PLWH were included (mean age 43.4 ± 11.7; 71.6% men); 60.3% of participants resided in Belgium and Brazil. COVID-19 and associated restrictive
measures seem detrimental to the well-being and follow-up of PLWH. |
|
|
Sii, CKS, Lee, et al |
Pediatr Surg Int |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
We report our experience with universal preoperative and preprocedural screening for COVID-19 in children requiring
general anaesthesia with low risk of having the infection. This was a data review involving children aged < 18 years undergoing procedures under general anaesthesia in our institution from 18th March to 31st May 2020 and deemed low risk for COVID 19 infection.
Of the 66 children, none were positive for COVID-19. |
|
|
Singh, G, Kapoor, et al |
Egypt Heart J |
Public Health response| Interventions de santé publique |
This study was conducted at the Hero DMC heart institute (a tertiary care center for cardiac diseases). The study design
is cross-sectional and involves a comparison of the pre-COVID-19 phase with the COVID-19 phase. All symptoms, need for hospitalization and clinical events were recorded. During pandemics, telemedicine offers a promising option for patient management with chronic
cardiac conditions. |
|
|
Singh, JA, Richards, et al |
Arthritis Care Res (Hoboken) |
Healthcare Response | Réponse des soins de santé |
We assess the experience, views and opinions of rheumatology providers at Veterans Affairs (VA) facilities about rheumatic
disease healthcare issues during the COVID‐19 pandemic. Of the 153 eligible VA rheumatologists, 103 (67%) completed the survey. A significant proportion of providers reported ≥50% increase related to COVID‐19 in visits. |
|
|
Protease Inhibitory Effect of Natural Polyphenolic Compounds on SARS-CoV-2: An In
Silico Study |
Singh, R, Gautam, et al |
Molecules |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
we have selected three polyphenolic compounds, mangiferin, glucogallin, and phlorizin. These compounds are isolated
from different natural sources but share structural similarities and have been reported for their antiviral activity. The objective of this study is to analyze and predict the anti-protease activity of these compounds on SARS-CoV-2main protease (Mpro) and
TMPRSS2 protein. The MD-simulation study has predicted that these natural compounds will have a great impact on the stabilization of the binding cavity of the Mpro of SARS-CoV-2. The predicted pharmacokinetic parameters also show that these compounds are expected
to have good solubility and absorption properties. |
|
Skariyachan, S, Gopal, et al |
Comput Biol Med |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The present study aimed to predict the binding potential of six FDA drugs towards fifteen protein targets of SARS-CoV-2
and propose the structural and molecular basis of the interaction by molecular docking and dynamic simulation. Based on the literature survey, fifteen potential targets of SARS-CoV-2, and six FDA drugs (Chloroquine, Hydroxychloroquine, Favipiravir, Lopinavir,
Remdesivir, and Ritonavir) were selected. The structural and molecular basis of interactions suggest that the FDA drugs can be repurposed towards multiple targets of SARS-CoV-2, and the present computational models provide insights on the scope of repurposed
drugs against COVID-19. |
|
|
Skittrall, JP, Wilson, et al |
Clin Microbiol Infect |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study estimates test specificity and positive predictive value to evaluate the impact of confirmatory testing,
and to improve clinical diagnosis, epidemiological estimation and interpretation of vaccine trials. Nucleic acid amplification testing for SARS-CoV-2 is highly specific. Nevertheless, when prevalence is low a significant proportion of initially positive results
fail to confirm and confirmatory testing substantially reduces false positive detections. Omitting additional testing in samples with higher prior detection probabilities focuses testing where clinically impactful and minimises delay. |
|
|
Smati, S, Tramunt, et al |
Diabetes Obes Metab |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Here, we specifically assessed the relationship between BMI classes and early COVID‐19 prognosis in inpatients with
type 2 diabetes (T2D). Clinical characteristics and COVID‐19‐related outcomes (i.e. intubation for mechanical ventilation [IMV], death and discharge by day 7 [D7]) were analyzed according to BMI status. After multivariable adjustment, primary outcome by D7
was significantly associated with obesity in patients under 75 years, while such association was no longer found in those over 75 years. The deleterious impact of obesity on COVID‐19 prognosis was no longer observed in the elderly. |
|
|
COVID-19 pandemic preventive behaviors and causal beliefs among Italian community
dwelling adults |
Somma, A, Gialdi, et al |
J Health Psychol |
Public Health response| Interventions de santé publique |
We showed that 1054 Italian participants' COVID-19-related preventive behaviors and causal beliefs were significantly
associated with selected demographic variables and frequency of use of specific sources of information (e.g. scientific journals vs social media). |
|
Sperotto, F, Wolfler, et al |
Eur J Pediatr |
Healthcare Response | Réponse des soins de santé |
We sought to evaluate the impact of the COVID-19 outbreak on PICU admissions in Northern Italy. We included all patients
admitted to 4 PICUs from 8-weeks-before to 8-weeks-after February 24th, 2020, and those admitted in the same period in 2019. Unplanned and medical admissions significantly decreased; intra-hospital, planned (potentially delayed by at least 12 h), and surgical
admissions did not significantly change. Patients admitted for respiratory failure significantly decreased. |
|
|
Strom, MA, Trager, et al |
J Am Acad Dermatol |
Clinical data| Données cliniques |
This study provides insights into the cutaneous manifestations of severe disease. Here, we report on the cutaneous
findings observed in hospitalized COVID-19 positive patients at Columbia University Irving Medical Center (CUIMC) by the adult dermatology consult service between 3/25/2020 and 5/1/2020. Cases were included if COVID-19 was most likely associated with or contributed
to skin findings observed after other potential causes were excluded |
|
|
Strömer, A, Rose, et al |
Microorganisms |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
Kinetics of neutralizing antibodies and immunoglobulin G (IgG) against the nucleo (N) or spike (S) proteins of severe
acute respiratory syndrome coronavirus type2 (SARS-CoV-2) were studied in patients up to 165 days after PCR diagnosis of infection. IgG kinetics, avidities, and virus-neutralizing capacities were recorded over up to 165 days in eleven patients and five individuals
from routine diagnostics. Sensitivities, specificities, and diagnostic accuracies ranged between 80.8–96.3%, 96.0–100%, and 93.7–99.2%, respectively. The titers were relatively low, suggesting that sustained humoral immunity is uncertain, especially after
outpatient SARS-CoV-2 infection. |
|
|
Su, W, Qiu, et al |
Aging (Albany NY) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We explored sex differences in clinical characteristics and potential risk factors for mortality in severe COVID-19
patients. In this retrospective cohort study, we included all severe COVID-19 patients admitted to Eastern Renmin Hospital of Wuhan University, Wuhan, China, with a definitive clinical outcome as of Apr 10, 2020. Males are more likely than females to develop
serious complications and progress to death. |
|
|
Bone marrow haemophagocytosis designate severe SARS-CoV-2 infections |
Swoboda, J, Wittschieber, et al |
Histopathology |
Clinical data| Données cliniques |
The aim of the present study was to perform morphological analyses and morphometry of haemophagocytosis in bone marrow
of patients with severe COVID‐19 and to correlate the findings to the clinical course of the disease. Bone marrow specimens of 15 deceased patients with severe course of COVID‐19 were sampled from vertebral column during autopsy. Haemophagocytosis is a common
finding in the bone marrow of deceased with severe COVID‐19 and may designate fatal SARS‐CoV‐2 infections. |
|
Szabo, PeterA, Dogra, et al |
medRxiv |
Immunology | Immunologie |
Here, we conducted longitudinal, high-dimensional profiling of paired airway and blood samples from patients with severe
COVID-19, revealing immune processes in the respiratory tract linked to disease pathogenesis. Our findings provide evidence that COVID-19 pathogenesis is driven by respiratory immunity, and rationale for site-specific treatment and prevention strategies. |
|
|
Sztajnbok, Jaques, Ribeiro, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
This study aims to evaluate the impact of staff preparedness by comparing the outcomes between two ICUs units from
the same hospital, one previously well-established and one recently assembled to deal with a markedly increased volume of patients brought by COVID-19 pandemic. We included all patients who were admitted to an ICU with suspected COVID-19, from March 1st until
April 30th, 2020 at Instituto de Infectologia Emílio Ribas, São Paulo-SP, Brazil. Age > 60 years, need of invasive mechanical ventilation and an ICU type (recently assembled) were independently associated with in-hospital mortality among patients with severe
acute respiratory syndrome during the COVID-19 pandemic. |
|
|
Tadesse, DB, Gebrewahd, et al |
New Microbes New Infect |
Healthcare Response | Réponse des soins de santé |
this study aimed to determine the knowledge, attitude, practice, and psychological response among nurses toward the
COVID-19 outbreak in Northern Ethiopia. The hospital-based cross-sectional study design was employed. The data were collected from March to April 2020. Of the 415 nurses, 307 (74%), 278 (67%), 299 (72%), and 354 (85.3%) had good knowledge, good infection prevention
practice, a favorable attitude, and disturbed psychological response towards COVID-19, respectively. |
|
|
Statin use is associated with lower disease severity in COVID-19 infection |
Tan, WYT, Young, et al |
Sci Rep |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Study the association of hyperlipidemia and statin use with COVID-19 severity. One hundred fifty-six (21.8%) patients
had dyslipidaemia and 97% of these were on statins; models showed a lower chance of ICU admission for statin users when compared to non-statin users. |
|
Risks and Benefits of Antibiotics vs. COVID-19 Morbidity
and Mortality |
Tanioka, Hisaya, Tanioka, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique
Healthcare Response | Réponse des soins de santé |
Analyze the potential association of each antibiotic consumption rate and use ratio with COVID-19 morbidity and mortality.
Cephalosporins were a negative correlation with mortality and morbidity. Penicillin had a weak positive correlation with them. Macrolides, quinolone, and sulfonate showed a slightly negative correlation tendency with mortality. Conclusions Cephalosporins may
affect less morbidity and mortality. Penicillin suggests to accelerate them. The combination of cephalosporins with macrolides or quinolones may be a helpful treatment. |
|
Tao, J, Gao, et al |
Diabetes Res Clin Pract |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
The factors affecting glycemic control in patients with type 2 diabetes included age, education level, glucose monitoring
equipment availability, medication adherence and the frequency of self-monitoring of blood glucose. The factor affecting glycemic control in patients with type 1 diabetes was education level. |
|
|
Tarquinio, C, Brennstuhl, et al |
Issues Ment Health Nurs |
Healthcare Response | Réponse des soins de santé |
Eye Movement Desensitization and Reprocessing used as emergency intervention for remote use in the treatment of healthcare
providers caring for COVID-19 patients. The therapy allowed for an improvement in the emotional state and a decrease in perceived disturbance, in a single session, and results are maintained 1 week after the intervention, despite the continued professional
activities of the participants and the continuity of the event. |
|
|
Taubman-Ben-Ari, O, Chasson, et al |
Health Soc Care Community |
Public Health response| Interventions de santé publique |
Examined two angles of childbirth anxieties of Jewish and Arab pregnant women in Israel during the COVID‐19 pandemic
(March‐April, 2020). Arab women reported higher level of COVID‐19‐related childbirth anxiety and COVID‐19‐related fears of being infected and concern for the foetus. Poorer health, being an Arab woman, being in the third trimester, lower self‐compassion, and
higher COVID‐19‐related fears contributed significantly to greater COVID‐19‐related childbirth anxiety. |
|
|
Platelets Promote Thromboinflammation in SARS-CoV-2 Pneumonia |
Taus, F, Salvagno, et al |
Arterioscler Thromb Vasc Biol |
Immunology | Immunologie |
Aim was to investigate whether subpopulations of platelets were programmed to procoagulant and inflammatory activities
in coronavirus disease 2019 (COVID-19) patients with pneumonia, without comorbidities predisposing to thromboembolism. The study concludes platelets in COVID-19 pneumonia are primed to spread proinflammatory and procoagulant activities in systemic circulation. |
|
Temiz, MZ, Yürük, et al |
Turk J Urol |
Healthcare Response | Réponse des soins de santé |
This study evaluates the overall healthcare performance of a re-organized urology clinic during the COVID-19 pandemic
in Turkey. |
|
|
The value of high-flow nasal cannula oxygen therapy in treating novel coronavirus pneumonia |
Teng, XB, Shen, et al |
Eur J Clin Invest |
Clinical data| Données cliniques |
COVID‐19 patient clinical data were collected to compare conventional therapy and the early application of High-flow
Nasal Cannula (HFNC). In patients with severe COVID‐19 can HFNC improved oxygenation and respiratory rate and improved the infection indexes of patients, and reduced the length of stay in the ICU of patients. |
|
Terebuh, PD, Egwiekhor, et al |
Influenza Other Respir Viruses |
Epidemiology| Épidémiologie Public Health Priorities| Priorités de santé publique Public
Health response| Interventions de santé publique |
Characterization of COVID‐19 clusters among vulnerable populations housed in congregate living settings across an entire
community in Ohio, US. For 25 clusters, an index case who frequently (88%) was a healthcare worker was identified. Engagement of clinical, community, and government partners through public health coordination efforts created opportunities to rapidly develop
and coordinate effective response strategies to support the facilities facing the dawning impact of the pandemic. |
|
|
Thabet, STM, Abdo, et al |
Results Phys |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Investigate the Coronavirus (COVID-19) mathematical model spread in Wuhan and Huanggang, China. Using fixed point
results the authors establish model outcomes under Atangana–Baleanu–Caputo (ABC) derivative with fractional order. |
|
|
Thakur, N, Conceicao, et al |
J Gen Virol |
Coronavirology| Coronavirologie |
SARS-CoV-2 has also been reported to induce syncytia formation in infected cells, with the spike protein initiating
cell–cell fusion. The authors demonstrated the broad applicability of the viral micro-fusion inhibition test (mFIT), examining neutralization of cell–cell fusion by monoclonal antibodies and recombinant proteins as well as sera from vaccinated animals and
plasma from naturally infected individuals. |
|
|
Tholin, B, Hauge, et al |
J Med Case Rep |
Clinical data| Données cliniques |
Present a Caucasian patient with COVID-19 who developed a marked elevation of inflammatory parameters with ferritin
36,023 μg/L, but also elevated C-reactive protein 334 mg/L and lactate dehydrogenase 1074 U/L, 1 week after admission to the intensive care unit. |
|
|
Tian, R, Wu, et al |
Sci Rep |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A single-center retrospective case–control study (n=90) patients hospitalized in Wuhan, China. Multivariable regression
showed higher qSOFA score and elevation of IL-6 in critical patients. Antibiotic usage and anticoagulation were associated with decreased in-hospital mortality. And critical grouping contributed greatly to in-hospital death. Critical COVID-19 patients have
a more severe clinical course. |
|
|
Tilley, K, Ayvazyan, et al |
J Adolesc Health |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique
Immunology | Immunologie |
The estimated prevalence of SARS-CoV-2 antibody was 4.0% (3.0%, 5.1%). Factors associated with having a positive test
included history of anosmia and/or loss of taste (95% CI: 1.4–9.6). A history of respiratory symptoms, with or without fever, was not associated with a positive antibody test. Prevalence of SARS-CoV-2 antibodies in the undergraduate and graduate student university
population was similar to community prevalence. |
|
|
Timmons, S, McGinnity, et al |
J Epidemiol Community Health |
Public Health Priorities| Priorités de santé publique Public Health response| Interventions
de santé publique |
Measure the effects of these biases on estimates of compliance with public health guidance (eg, hand-washing, social
distancing). Estimates of compliance with COVID-19 guidance vary substantially with how the question is asked. Standard tracking surveys tend to pose questions in ways that lead to higher estimates than alternative approaches. Experimental tests of these surveys
offer public health officials greater insight into the range of likely compliance estimates to better inform policy and communications. |
|
|
Tomlinson, J, Khan, et al |
Clin Med (Lond) |
Healthcare Response | Réponse des soins de santé |
The aim of this audit was to reduce face-to-face exposure time during inpatient care of patients with suspected/confirmed
COVID-19 using a telecommunications-based approach. 76 patients were included in the audit. The audit confirms telecommunications can be integrated successfully into the daily inpatient ward round structure, reducing face-to-face exposure time while maintaining
patient satisfaction and safety. |
|
|
Tonen-Wolyec, S, Dupont, et al |
PLoS One |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Public
Health response| Interventions de santé publique |
The practicability of a prototype capillary whole-blood IgG-IgM COVID-19 self-test as a self serological screening
tool for SARS-CoV-2 infection adapted to the general public was evaluated in a cross-sectional, general adult population study. |
|
|
Tosi, D, Campi, et al |
J Med Internet Res |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
A predictive model constructed in the early days of the pandemic in Italy to promptly predict the curve of total positive
cases in Italy and the Lombardy Region. |
|
|
Severe Neonatal Coronavirus Disease 2019 Presenting as Acute Respiratory Distress
Syndrome |
Trieu, C, Poole, et al |
Pediatr Infect Dis J |
Clinical data| Données cliniques |
Highlights a severe case of neonatal coronavirus disease 2019 with acute respiratory distress syndrome. |
|
Trivedi, Anusua, Ortiz, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Develop a novel patient-level algorithm to aggregate the chest CT volume into a 2D representation that can be easily
integrated with clinical metadata to distinguish Novel Coronavirus Pneumonia (COVID-19+) from other cases of viral pneumonia and normal healthy chest CT volumes with state-of-the-art performance. |
|
|
Trivedi, Anusua, Ortiz, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Develop a novel patient-level algorithm to aggregate the chest CT volume into a 2D representation that can be easily
integrated with clinical metadata to distinguish Novel Coronavirus Pneumonia (COVID-19+) from other cases of viral pneumonia and normal healthy chest CT volumes with state-of-the-art performance. |
|
|
Trpkov, C, MacMullan, et al |
CJC Open |
Clinical data| Données cliniques |
Describe a 62-year-old female with COVID-19 who developed acute respiratory failure and cardiogenic shock in the setting
of a systemic hyper-inflammatory state and apparent myocardial infarction. |
|
|
Headache characteristics in COVID-19 pandemic-a survey study |
Uygun, Ö, Ertaş, et al |
J Headache Pain |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Bilateral, long-lasting headaches, resistance to analgesics and having male gender were more frequent in people with
COVID-19 in conjunction with anosmia/ageusia and gastrointestinal complaints. These features may be helpful for diagnosing the headache related to COVID-19 during the pandemic. |
|
Concerns and adjustments: How the Portuguese population met COVID-19 |
Valente de Almeida, S, Costa, et al |
PLoS One |
Public Health response| Interventions de santé publique |
Examine perceptions and behaviours of the Portuguese population regarding social and economic impacts of the COVID-19
pandemic, allowing for more informed public policies. |
|
Valeria, P, Merhnaz, et al |
Ann Phys Rehabil Med |
Healthcare Response | Réponse des soins de santé |
Evaluated the impact of the COVID-19 lockdown on patients with Charcot-Marie-Tooth (CMT) neuropathy, the most common
genetic neuromuscular disorder. People with CMT worldwide reported significantly impaired physical skills and pain worsening after the COVID-19 lockdown. These symptoms were caused by a relevant decrease in walking and the lack of guidance in physical activity
by healthcare professionals. |
|
|
Psychological Wellbeing of Vulnerable Children During the COVID-19 Pandemic |
Vallejo-Slocker, L, Fresneda, et al |
Psicothema |
Public Health response| Interventions de santé publique |
Children and adolescents in residential care, foster families, kinship families, or family strengthening programs under
SOS Children’s Villages Spain (n=459) were evaluated using the SDQ to measure internalizing and externalizing problems and using KIDSCREEN-10 index to measure heath related quality of life. Children and adolescents in this study had worse psychological wellbeing
than those in the 2017 Spanish reference, that is, before the COVID-19 outbreak. Quality of life remained the same. No differences between care modalities were found. |
|
Vanaerschot, M, Mann, et al |
J Clin Microbiol |
Coronavirology| Coronavirologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The data show even in areas of high SARS-CoV-2 community spread, G29140U replication-competent, mutants that impair
RT-PCR performance can emerge and spread, leading to reduced test sensitivity and potentially under-diagnosis, especially if only one viral target is used in testing. |
|
|
Vespa, E, Pugliese, et al |
J Hepatol |
Clinical data| Données cliniques |
A case series that could not replicate the finding that COVID-19 patients presenting with abnormal liver function tests
at admission evolve towards a more severe form of pneumonia. |
|
|
Analysis of impact on tissue activity during COVID-19 outbreak: a survey of 8 banks
in Spain |
Villalba, R, Santos, et al |
Cell Tissue Bank |
Public Health Priorities| Priorités de santé publique Healthcare Response | Réponse
des soins de santé |
Evaluation of the possible impact on the procurement, processing and distribution of donor organs and tissues during
the peak period of the pandemic COVID-19 in Spain. The data suggests coronavirus to have dramatically affected tissue donation, but have had a moderate effect on stored tissues such as bone, valves, vessels or skin. |
|
Vitale, E, Mea, et al |
Endocr Metab Immune Disord Drug Targets |
Healthcare Response | Réponse des soins de santé |
Nurses engaged in the treatment of the most serious patients with Covid-19 are subjected to very high levels of stress
due to the nature of the nursing job, shifting, poor rest, anxiety due to health emergency period and weight gain. |
|
|
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates |
Walsh, EE, Frenck, et al |
N Engl J Med |
Vaccine Research| Recherche sur les vaccins |
The safety and immunogenicity data from a U.S. phase 1 trial of two vaccine candidates in younger and older adults,
added to earlier interim safety and immunogenicity data regarding BNT162b1 in younger adults from trials in Germany and the United States, support the selection of BNT162b2 for advancement to a pivotal phase 2–3 safety and efficacy evaluation. |
|
Wang, D, Baudys, et al |
Anal Chem |
Coronavirology| Coronavirologie |
Describe a comprehensive, high-fidelity mass spectrometric approach to the glycosylation analysis of SARS-CoV-2 S protein,
applied to multiple recombinant spike protein sources and constructs (S1 domain and ectodomain) with identical analytical methods. |
|
|
Wang, Ding, Zuo, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public Health response| Interventions
de santé publique |
The COVID-19 pandemic has affected travel behaviors and transportation system operations, and cities are grappling
with what policies can be effective for a phased reopening shaped by social distancing. This edition of the white paper updates travel trends and highlights an agent-based simulation model's results to predict the impact of proposed phased reopening strategies.
It also introduces a real-time video processing method to measure social distancing through cameras on city streets. |
|
|
Wang, H, Tu, et al |
J Immunol Res |
Healthcare Response | Réponse des soins de santé |
Inaccessibility to medications is a serious problem for IBD patients after city shutdown. Efforts have to be made to
address the problems of drug withdrawal and psychological issues that IBD patients suffer from during the COVID-19 outbreak. |
|
|
Wang, Q, Zhao, et al |
Emerg Microbes Infect |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Overview of the transformation of an a non-nucleic acid testing laboratory into a SARS-CoV-2 nucleic acid testing laboratory.,
within 48 hours in Beijing China. |
|
|
Wang, SH, Govindaraj, et al |
Inf Fusion |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Develop an artificial intelligence based tool to diagnose of chest CT images (n=320). |
|
|
Predictive Models of Mortality for Hospitalized Patients With COVID-19: Retrospective Cohort
Study |
Wang, T, Paschalidis, et al |
JMIR Med Inform |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
The aim of this study was to develop accurate models to predict the mortality of hospitalized patients with COVID-19
using basic demographics and easily obtainable laboratory data. The models developed using data from throughout the patients’ length of stay demonstrated accuracies as high as 97%, whereas the models with admission laboratory variables possessed accuracies
of up to 93%. The latter models predicted patient outcomes an average of 11.5 days in advance. Key variables such as age, lactate dehydrogenase, high-sensitivity C-reactive protein, and percentage of lymphocytes in the blood were indicated by the models. |
|
Wang, Y, Jing, et al |
Int J Public Health |
Public Health response| Interventions de santé publique |
This study aimed to understand the status of positive affect (PA) and negative affect (NA) on university and college
students, and to explore the determinants during the COVID-19 outbreak. Of 17,876 participants, the mean score of PA was 25.5 ± 7.3, while NA was 19.1 ± 7.1. Multiple linear regression models showed that there are some common determinants of PA and NA, such
as education, health literacy on communicable diseases, satisfaction with measures for epidemic prevention and control, risk of infection, impact of the outbreak on daily life, sleep duration and frequency of hand washing in the past 2 weeks. Besides, whether
the student is a medical major and whether outing in the past 2 weeks were specific determinants of PA, and frequency of masks wearing was specific determinant of NA. |
|
|
Wang, Y, Ma, et al |
Transl Psychiatry |
Healthcare Response | Réponse des soins de santé |
To study the acute psychological effects of Coronavirus Disease 2019 (COVID-19) outbreak among healthcare workers (HCWs)
in China, a cross-sectional survey was conducted among HCWs during the early period of COVID-19 outbreak. The prevalence of depression, anxiety, and PTSD was estimated at 15.0%, 27.1%, and 9.8%, respectively. |
|
|
Wang, Z, Zheng, et al |
Lab Chip |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We present a lateral flow immunoassay kit based on a selenium nanoparticle-modified SARS-CoV-2 nucleoprotein, which
detects anti-SARS-CoV-2 IgM and anti-SARS-CoV-2 IgG in human serum, and the results can be read by the naked eye in 10 minutes. Thus kit demonstrated a sensitivity and specificity of 93.33% and 97.34%, respectively. |
|
|
Watzky, M, de Dieuleveult, et al |
Environ Res |
Clinical data| Données cliniques |
In here, exploiting a large panel of publicly available genome-wide data, we investigated whether the human receptor
ACE2 and human proteases TMPRSS2, FURIN and CATHEPSINs (B, L and V), which are involved in SARS-CoV-2 cell entry, are transcriptionally regulated by environmental cues. We report that more than 50 chemicals modulate the expression of ACE2 or human proteases.
Our exploratory study documents an influence of environmental exposures on the expression of genes involved in SARS-CoV-2 cell entry. |
|
|
Wei, Y, Yu, et al |
Ital J Pediatr |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to quantify the impact of coronavirus disease 2019 (COVID-19) on pediatric operations. During
the COVID-19 pandemic, 62.68% fewer patients underwent surgery than during the homologous period of time 1 year earlier. After the COVID-19 pandemic, the number of orchidopexy cases increased significantly from 175.14 to 504.57 per week. After measures were
implemented, the number of operations performed remained stable and comparable to the pre-pandemic period. COVID-19 RNA detection was performed in 5104 cases and there were no new confirmed cases in our hospital. |
|
|
Williams, N, Idriss, et al |
J Clin Pathol |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study was performed to better understand the time frame associated with changes in SARS-CoV-2 nucleic acid testing
and provide recommendations for repeat testing. The Interquartile Range (IQR) of data for patients who had a negative to positive change in laboratory testing (progression) was 6-16 days (median=9 days). The IQR of data for patients who had a positive to negative
change in test results (remission) was 9-21 days (median=14 days). Repeat testing should be performed swiftly when symptomatic patients are negative. |
|
|
Williams, ThomasC, MacRae, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
In this retrospective cohort study we examined paediatric health-care utilisation, incidence of severe disease, and
mortality during the lockdown period in Scotland. To determine whether social distancing measures and caregiver behavioural changes were associated with delayed care-seeking and increased disease severity on presentation, unplanned, emergency admissions requiring
invasive mechanical ventilation for the two national Paediatric Intensive Care Units were analysed. National lockdown led a reduction in paediatric emergency care utilisation, without associated evidence of severe harm. |
|
|
Wilson, RF, Sharma, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
To identify factors that influence exposure to COVID-19 among young adults in Winnebago County, Wisconsin characteristics
of COVID-19 cases and drivers of behaviors in this age group were examined. During March 1-July 18, 2020, 240 young adults received positive SARS-CoV-2 test results, accounting for 32% of all Winnebago County cases. In 30 key informant interviews, most interviewees
reported exposure to misinformation, conflicting messages, or opposing views about the need for and effectiveness of masks. Thirteen young adults described social or peer pressure to not wear a mask and perceived severity of disease outcome for themselves
as low but high for loved ones at risk. |
|
|
Wollenstein-Betech, S, Silva, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We use nation-wide multicenter data of COVID-19 patients in Brazil to predict mortality and ventilator usage. Variables
highly predictive of mortality included geographic location of the hospital; renal and liver chronic disease; immunosuppression; obesity; neurological, cardiovascular, and hematologic disease; diabetes; chronic pneumopathy; immunosuppression; respiratory symptoms;
hospitalization in a public hospital; and self-reported patient illiteracy. Validation accuracies (AUC) for predicting mortality and ventilation need reach 79% and 70%, respectively, when using only pre-admission variables and 86% and 87% when using post-admission
information. |
|
|
Wongtanasarasin, W, Srisawang, et al |
Emerg Med Australas |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to evaluate the impact of the national lockdown due to the COVID-19 pandemic towards
the Emergency Department (ED) visits and admission rates in Thailand. The national lockdown in Thailand was associated with a significant reduction in average daily ED visits across traumatic and non-traumatic patients. |
|
|
PMC7534598; Furin: A Potential Therapeutic Target for COVID-19 |
Wu, C, Zheng, et al |
iScience |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We found that the Spike protein of SARS-CoV-2 contains a furin cleavage site, which did not exist in any other betacoronavirus
subtype B. Based on a series of analysis, we speculate that the presence of a redundant furin cut site in its Spike protein is responsible for SARS-CoV-2's stronger infectious nature than other coronaviruses, which leads to higher membrane fusion efficiency.
Subsequently, a library of 4,000 compounds including approved drugs and natural products was screened against furin through structure-based virtual screening and then assayed for their inhibitory effects on furin activity. Among them, an anti-parasitic drug,
diminazene, showed the highest inhibition effects on furin, which might be used for the treatment of COVID-19. |
|
Chest radiograph at admission predicts early intubation among inpatient COVID-19
patients |
Xiao, N, Cooper, et al |
Eur Radiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective cohort study reviewed COVID-19 patients who were admitted to an urban medical center in Chicago.
Chest radiography at the time of admission independently predicted time to intubation within 48 h and during the hospital stay in COVID-19 patients. More opacities on chest radiography were associated with several fold increases in early mechanical ventilation
among COVID-19 patients. |
|
Host metabolite-cytokine correlation landscape in SARS-CoV-2 infection |
Xiao, Nan, Nie, et al |
Research Square prepub |
Clinical data| Données cliniques Immunology | Immunologie Animal model | Modèle animal |
Here, we performed both metabolomics and cytokine/chemokine profiling on serum samples from the same cohort of healthy
controls, mild and severe COVID-19 patients and delineated the global metabolic and immune response landscape along disease progression. The correlation analysis revealed the tight link between metabolites and proinflammatory cytokines and chemokines, implying
the potential regulatory role of arginine metabolism, tryptophan metabolism, and purine metabolism in hyperinflammation. We demonstrated that targeting metabolism markedly modulated the proinflammatory cytokines release by peripheral blood mononuclear cells
isolated from SARS-CoV-2-infected rhesus macaques ex vivo. |
|
Xiong, C, Hu, et al |
Proc Natl Acad Sci U S A |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Using mobile device location data of over 100 million monthly active samples, we compute origin-destination travel
demand and aggregate mobility inflow at each US county from March 1 to June 9, 2020. Our simultaneous equations analysis highlights the dynamics in a positive relationship between mobility inflow and the number of infections during the COVID-19 onset. This
relationship is found to be increasingly stronger in partially reopened regions. |
|
|
Xiong, H, Ye, et al |
Anal Chem |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In this work, we successfully developed a portable microfluidic system for the rapid, accurate, and simultaneous detection
of SARS-CoV, middle east respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2, and four other human coronaviruses . The disk-like microfluidic platform integrated with loop-mediated isothermal amplification provides highly accurate, sensitive, and specific
results with a wide linear range within 40 min. The diagnostic tool achieved 100% consistency with the "gold standard" polymerase chain reaction in detecting 54 real clinical samples. |
|
|
Xu, H, Gonzalez Mendez, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
This study aimed to assess the knowledge and awareness of and attitudes toward the COVID-19 pandemic among different
populations in Central China during the critical period of the outbreak. 380 students (74.8%), 39 medical workers (7.7%), and 89 people with other occupations (17.5%) participated in this survey. All three groups reported an adequate background knowledge about
COVID-19 but medical workers showed a slightly advanced knowledge in their responses to professional questions. Most of the participants were highly concerned about COVID-19 during the critical period of the outbreak. The majority of respondents declared that
the village/city lockdown policy had a significant impact on their daily life but most of them held an optimistic attitude toward the control of COVID-19. |
|
|
GASNet: Weakly-supervised Framework for COVID-19 Lesion Segmentation |
Xu, Zhanwei, Cao, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Segmentation of infected areas in chest CT volumes is of great significance for further diagnosis and treatment of
COVID-19 patients. In this paper, we propose a weakly-supervised lesion segmentation framework by embedding the Generative Adversarial training process into the Segmentation Network, which is called GASNet. GASNet is optimized to segment the lesion areas of
a COVID-19 CT by the segmenter, and to replace the abnormal appearance with a generated normal appearance by the generator, so that the restored CT volumes are indistinguishable from healthy CT volumes by the discriminator. The performance of GASNet is comparable
to fully-supervised segmentation algorithms trained on dozens of voxel-level labeled samples. |
|
Yang, P, Wang, et al |
J Med Virol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we explored the associations between admission fasting plasma glucose (FPG) and 28-day mortality in
COVID-19 patients. Patients with diabetes had higher neutrophil count and D-dimer, less lymphocyte count, lower albumin level, and more fatal complications. Multivariable Cox regression analyses showed that age, admission FPG between 7.0 and 11.0 mmol/L and
≥11.1 mmol/L, chronic obstructive pulmonary disease, and cardiac injury were independent predictors of 28-day mortality in COVID-19 patients. |
|
|
Clinical characteristics of COVID-19 patients with HIV coinfection in Wuhan,
China |
Yang, R, Gui, et al |
Expert Rev Respir Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
This study investigates the impact of HIV co-infection and anti-HIV drugs on clinical characteristics of COVID-19 patients.
Compared with 53 COVID-19 patients without HIV infection, the patients with SARS-CoV-2 and HIV co-infection had higher maximum body temperatures, longer duration of fever , longer time to have improvement of chest CT images, and lower level of SARS-CoV-2
IgG. However, no statistically significant difference of duration of SARS-CoV-2 shedding in the two groups was found (12.3±2.6 vs 13.4±2.4 days, t=0.238, P=0.813). |
|
Yang, R, Mei, et al |
BMC Med |
Transmission Clinical data| Données cliniques |
This retrospective cohort study investigates the association between pregnant women with COVID-19 and the risk of adverse
birth outcomes in China. Compared to pregnant women without COVID-19, pregnant women with a confirmed COVID-19 diagnosis had an increased risk of preterm birth and cesarean section. Among these newborns that were born to mothers with confirmed COVID-19, none
were SARS-CoV-2 positive or had abnormal CT results. |
|
|
COVID-19 cases in US counties: roles of racial/ethnic density and residential
segregation |
Yang, TC, Emily Choi, et al |
Ethn Health |
Epidemiology| Épidémiologie |
The objective of this study was to investigate how racial/ethnic density and residential segregation shape the uneven
burden of COVID-19 in US counties. Counties with high racial/ethnic density of minority groups experience more confirmed cases than those with low levels of density. High levels of residential segregation between whites and non-whites increase the number of
COVID-19 infections in a county, net of other risk factors. The relationship between racial/ethnic density and COVID-19 infections is enhanced with the increase in residential segregation between whites and non-whites in a county. |
|
Yao, X, Liu, et al |
Eur J Neurosci |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to explore the clinical characteristics and prognosis of COVID-19 patients in China
with cerebral stroke. Most COVID-19 patients with stroke were elderly with more comorbidities, such as hypertension, diabetes and heart diseases than patients without stroke. The mortality rate of stroke patients was almost double (12.4% vs 6.9%) that of patients
without stroke. In addition, age, male sex and hypertension were independent predictors for new cerebral stroke in COVID-19 patients. |
|
|
Yazdanpanah, Y |
J Med Virol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We conducted a multicentric prospective cohort of COVID-19 hospitalized patients in France to describe clinical, biological
and virological characteristics at hospital admission and over time according to mortality up to Day 60 after admission. In multivariate analysis, mortality at Day 60 was associated with older age, gender, chronic pulmonary disease, obesity and diabetes. The
median nasopharyngeal viral load at admission was 6.4 log(10) copies/mL and was associated with mortality regardless of clinical risk factors. Viral load decreased with time elapsed since symptoms onset. |
|
|
Yeramaneni, S, Doshi, et al |
Gastroenterology |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The purpose of this study was to evaluate the reported protective effect of famotidine on mortality in hospitalized
COVID-19 patients. In this multicenter retrospective study, in-hospital famotidine use within 24 hours of admission did not confer additional risk or benefit to 30-day mortality. Secondary analysis, accounting for interaction between in-hospital and at-home
famotidine use showed that patients not using famotidine at-home, but receiving famotidine in the hospital were at higher risk of 30-day mortality. |
|
|
Yilmaz, MM, Szabolcs, et al |
Am J Dermatopathol |
Clinical data| Données cliniques |
Here, we summarize histopathologic examination from an autopsy, including the cutaneous lesions from the affected and
normal contralateral toes and correlate them with systemic findings. Our findings suggest that critically ill patients with SARS-CoV-2 have different pathological processes affecting skin at peripheral sites (ie, fingers, toes, ears, and nose), which may be
due to thromboembolic events. |
|
|
Yim, KM, Yim, et al |
J Dermatolog Treat |
Healthcare Response | Réponse des soins de santé |
This study investigates how the pandemic has affected dermatology practices and identifies methods to maximize clinical
efficiency while maintaining patient safety. On average, there was a 65.2% decrease in patient volume during the initial surge of the COVID-19 outbreak, which was improved to a 15.5% decrease in July 2020. Despite this reduction in patient volume, the proportion
of acute dermatologic issues, biopsies performed, and skin cancer concerns were all increased compared to pre-COVID. |
|
|
Yuan, L, Kim, et al |
Phys Imaging Radiat Oncol |
Therapeutics| Thérapeutique |
This study aimed to establish an efficient planning technique for low dose whole lung treatment that can be implemented
rapidly and safely. The treatment technique developed here relied only on chest radiograph and a simple empirical monitor unit calculation formula. The 3D dose calculation in a real patient anatomy, including both nonCOVID and COVID-19 patients, which took
into account tissue heterogeneity showed that the dose delivered to lungs had reasonable uniformity even with this simple and quick setup. |
|
|
PMC7553855; COVID-19 with spontaneous pneumothorax, pneumomediastinum and subcutaneous
emphysema |
Zayet, S, Klopfenstein, et al |
New Microbes New Infect |
Clinical data| Données cliniques |
We present a case of COVID-19 pneumonia associated with spontaneous pneumothorax, pneumomediastinum and subcutaneous
emphysema in an immunocompetent patient with no past history of smoking or chronic obstructive pulmonary disease (COPD). This is the first case of spontaneous pneumothorax, pneumomediastinum and subcutaneous emphysema due to COVID-19 in France. The only risk
factor of this patient was prolonged cough. We hypothesis the mechanism underlying the pneumomediastinum is the aggressive disease pathophysiology in COVID-19 with an incresead risk of alveolar damage. |
|
The strategies of perioperative management in orthopedic department during the
pandemic of COVID-19 |
Zeng, H, Li, et al |
J Orthop Surg Res |
Healthcare Response | Réponse des soins de santé |
In the hope of providing a reference and recommendation for the prevention and control of the COVID-19, we carried
out research to improve the quality of patient care and prevention during this epidemic. All of the staff were trained rapidly to master personal protection in our department in China. We reviewed the patients' discharged records who underwent surgery in our
department during January 1 to March 1, 2019, and January 1 to March 1, 2020. With the help of the strict flow charts and smart equipment, post-operation outcomes of the patients revealed that the rates of the complications and re-operation had been reduced
significantly. No patient and staff caught COVID-19 infection or mortality during the epidemic. |
|
Zhang, MM, Niu, et al |
J Adv Nurs |
Healthcare Response | Réponse des soins de santé |
This aim of this study is to explore the psychological changes of nurses during home isolation, the factors that related
with these changes, and coping strategies in home isolation during the epidemic of COVID-19 in China. Nurses had many negative emotional reactions in the early stages of isolation and positive emotions gradually increased during home isolation. After release
from home isolation, they become more confident and calm after. Six categories of coping strategies were identified, including reasoned cognition; autosuggestion; develop healthy protective behaviours; shifting attention; social support; and the power of a
role model. |
|
|
Drug Repurposing for COVID-19 via Knowledge Graph Completion |
Zhang, Rui, Hristovski, et al |
arXiv |
Therapeutics| Thérapeutique |
The objective of this study was to discover candidate drugs to repurpose for COVID-19 using literature-derived knowledge
and knowledge graph completion methods. We use several state-of-the-art, neural network-based algorithms for the task, and also complement these approaches with an approach based on discovery patterns. We propose a novel, integrative, and neural network-based
literature-based discovery (LBD) approach to identify drug candidates from both PubMed and COVID-19-focused research literature. Some known drugs linked to COVID-19 in the literature were identified, as well as some candidate drugs that have not yet been studied.
Among them, five highly ranked and novel drugs (paclitaxel, SB 203580, alpha 2-antiplasmin, pyrrolidine dithiocarbamate, and butylated hydroxytoluene) with their mechanistic explanations were further discussed. |
|
Zhang, Y, Xie, et al |
Ital J Pediatr |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study was to investigate the epidemic, clinical, and imaging features of pediatric COVID-19 pneumonia for early
diagnosis and treatment. Among 30 children with mild COVID-19, seven had no symptoms and fifteen had low or mediate fever. Among eleven children with moderate COVID-19, nine presented with low or mediate fever, accompanied with cough and runny nose, and two
had no symptoms. Significantly more children had a greater rate of cough in moderate than in mild COVID-19. Thirty children with mild COVID-19 were negative in pulmonary CT imaging, whereas eleven children with moderate COVID-19 had pulmonary lesions |
|
|
Zhao, J, Wang, et al |
CNS Neurosci Ther |
Healthcare Response | Réponse des soins de santé |
We sent a survey to physicians worldwide through the network of the World Stroke Organization to investigate the impact
of COVID-19 on stroke clinics. The COVID-19 pandemic caused a significant drop of in-person outpatient visits and inpatient services. Clinic visits recovered slower than inpatient services in stroke and other neurological diseases after the pandemic. |
|
|
Zhao, L, Feng, et al |
BMJ Open |
Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions
de santé publique |
The objective of this study was to compare the epidemiological characteristics and transmission dynamics in relation
to interventions against the COVID-19 and severe acute respiratory syndrome (SARS) outbreak in mainland China. Compared with SARS, COVID-19 affected more extensive areas within a shorter time and had higher attack rate. SARS-CoV-2 was more likely to infect
older people. The case fatality rate (CFR) of either disease increased with age, but the CFR of COVID-19 was significantly lower than that of SARS (5.6% vs 6.4%). The trajectory of effective reproduction number dynamically changed in relation to interventions,
which fell below 1 within 2 months for COVID-19 and within 5.5 months for SARS. |
|
|
Zhao, X, Fan, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
The aim of this study is to explore how people in China are using the internet for seeking health information during
a pandemic. Many patients faced difficulties accessing offline health care services. In general, our findings confirmed that the internet is used by the Chinese public as an important source of health information. A high proportion of female users were seeking
health information and help for their parents or for older adults at home. The most searched information included accessing medical treatment, managing self-quarantine, and offline to online support. |
|
|
A Spatial-Temporal Graph Based Hybrid Infectious Disease Model with Application to COVID-19 |
Zheng, Yunling, Li, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, we combine a SEIR (susceptible-exposed-infectious-recovered) model and a RNN (recurrent neural network)
model on a graph structure to develop a hybrid spatio-temporal model to achieve both accuracy and efficiency in training and forecasting. The resulting hybrid model (called IeRNN) improves the prediction accuracy on state-level COVID-19 new case data from
the US, out-performing standard temporal models (RNN, SEIR, and ARIMA) in 1-day and 7-day ahead forecasting. |
|
Zhou, Y, Asante, et al |
J Nurs Manag |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to assess the performance of frontline nurses, who believed they were living out their calling,
during the COVID-19 pandemic in China. Drawing on the theory of work as a calling, we found that living a calling had a positive effect on frontline nurses' performance through the clinical and relational care they provided. Perceived supervisor support strengthened
these mediated relationships. |
|
|
On Bayesian sparse canonical correlation analysis via Rayleigh quotient framework |
Zhu, Qiuyun, Atchade, et al |
arXiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We have developed in this work a flexible semiparametric Bayesian inference for sparse canonical correlation analysis.
As an application, we use the methodology to maximally correlate clinical variables and proteomic data for a better understanding of covid-19 disease. Our analysis identifies the protein Alpha-1-acid glycoprotein 1 (AGP 1) as playing an important role in the
progression of Covid-19 into a severe illness. |
|
|
Intensive Care Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective cohort study was performed among adult COVID-19-positive patients (using real-time reverse transcriptase–polymerase
chain reaction assay) with a hospital visit between February 28 and March 26, 2020, at eight teaching hospitals of the Assistance Publique-Hôpitaux de Paris. ICU admission and/or death occurred in 8%, 18%, and 43% of the patients in sub-phenotypes #1, #2,
and #3, respectively (supplementary Fig. 1). . 7%, 13%, and 29% of patients required ICU admission in sub-phenotype #1, #2, and #3, respectively. In each respective sub-phenotype, 3%, 9%, and 22% of patients died. Sub-phenotype #3 (n = 150) included mostly
male (70.7%) older patients (median age 73 [IQR = 19.3]) with more comorbidities (mean 2.2/patient), pervasive chronic hypertension (94%), and frequent treatment with RAASi (67%). A minority of patients in sub-phenotype #3 presented with fever (23%) or pulmonary
symptoms (dyspnea 45%, cough 42%), and rarely other systemic symptoms (mean 0.65/patient, i.e., myalgia 13%, headaches 7%, gastrointestinal symptoms 19%). |
|
|
Abate, SM, Mantefardo, et al |
Patient Saf Surg |
Review Literature| Revue de littérature |
SR-MA: search was conducted in PubMed/Medline; Science direct and LILACS from December 29, 2019, to August15, 2020,
without language restriction. The unexpected high postoperative mortality rate in SARS-CoV-2 infected patients of 20% in the global literature mandates further scrutiny in assuring appropriate surgical indications and perioperative surgical safety measures
in this vulnerable cohort of patients. |
|
|
Pediatric Asthma and COVID-19: the Known, the Unknown and the Controversial |
Abrams, EM, Sinha, et al |
Pediatr Pulmonol |
Review Literature| Revue de littérature |
|
|
Ahmed, K, Bukhari, et al |
JMIR Public Health Surveill |
Review Literature| Revue de littérature |
|
|
|
Akiyama, S, Hamdeh, et al |
Ann Rheum Dis |
Review Literature| Revue de littérature |
SR-MA: searched PubMed/MEDLINE, Scopus, EMBASE, medRxiv from inception to 31 July 2020. Our meta-analysis demonstrated
that patients with autoimmune diseases had an increased risk of COVID-19, primarily attributed to glucocorticoid use. b/tsDMARDs monotherapy was associated with a lower risk of severe COVID-19 suggesting its safety in the COVID-19 pandemic. |
|
|
Al-Khawaga, S, Abdelalim, et al |
Stem Cell Res Ther |
Review Literature| Revue de littérature |
|
|
|
Amer, Yasser Sami, Titi, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
SR: Medline (OVID), CINAHL (EBSCO), EMBASE, CNKI, CBM, WanFang, and relevant databases and websites were systematically
searched through 31 st July 2020. Most of the RGs for critical care in response to COVID-19 included in the review showed a low overall quality (less than 40%). Future RGs for COVID-19 need to rely, for their development, on standard evidence-based methods
and tools. F |
|
|
Apostolopoulou, A, Esquer Garrigos, et al |
Diagnostics (Basel) |
Review Literature| Revue de littérature |
SR: searched PUBMED for eligible studies published until July 26, 2020. In conclusion, our findings indicate that the
diagnosis of CAPA needs a strong correlation between clinical, radiographic and laboratory data |
|
|
Asthma and severe acute respiratory syndrome coronavirus 2019: current evidence
and knowledge gaps |
Assaf, SM, Tarasevych, et al |
Curr Opin Pulm Med |
Review Literature| Revue de littérature |
|
|
Balmuri, N, Onel, et al |
Pediatr Rheumatol Online J |
Review Literature| Revue de littérature |
|
|
|
BCG vaccine, a ray of hope in treating Severe Acute Respiratory Syndrome
(SARS) |
Banerjee, AB, Singh, et al |
Infect Disord Drug Targets |
Review Literature| Revue de littérature |
|
|
PMC7550117; The practice of cytopathology during the era of COVID-19: challenges
and changes |
Baskota, SU, Chandra, et al |
Diagn Histopathol (Oxf) |
Review Literature| Revue de littérature |
|
|
Baviskar, T, Raut, et al |
Immunopharmacol Immunotoxicol |
Review Literature| Revue de littérature |
|
|
|
Rituximab as the treatment of pemphigus vulgaris in the COVID-19 pandemic era: A narrative
review |
Beyzaee, AM, Rahmatpour Rokni, et al |
Dermatol Ther |
Review Literature| Revue de littérature |
|
|
Pharmacological insight into potential therapeutic agents for the deadly Covid-19
pandemic |
Bhandari, R, Khanna, et al |
Eur J Pharmacol |
Review Literature| Revue de littérature |
|
|
Disinformation in the Online Information Ecosystem: Detection, Mitigation and Challenges |
Bhattacharjee, Amrita, Shu, et al |
arXiv |
Review Literature| Revue de littérature |
|
|
Bienvenu, LA, Noonan, et al |
Cardiovasc Res |
Review Literature| Revue de littérature |
|
|
|
Coronavirus disease-2019: implications for the gastroenterologist |
Bilal, M, Sawhney, et al |
Curr Opin Gastroenterol |
Review Literature| Revue de littérature |
|
|
High rates of pulmonary artery occlusions in COVID-19. A meta-analysis |
Birocchi, S, Manzoni, et al |
Eur J Clin Invest |
Review Literature| Revue de littérature |
MA: searched MEDLINE for studies published until June 6(th) , 2020. The results of our meta-analysis highlight a disproportion
in the prevalence of PE among all VTE events in COVID 19 patients, likely reflecting PAO by pulmonary thrombi, rather than emboli from peripheral vein thrombi. |
|
PMC7524535; Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity |
Burtscher, J, Cappellano, et al |
iScience |
Review Literature| Revue de littérature |
|
|
Cabrini, L, Ghislanzoni, et al |
Minerva Cardioangiol |
Review Literature| Revue de littérature |
|
|
|
Immune Therapy, or Antiviral Therapy, or Both for COVID-19: A Systematic Review |
Cantini, F, Goletti, et al |
Drugs |
Review Literature| Revue de littérature |
SR: Medline, Google Scholar, and MedRxiv databases were used to perform the review. The literature search was extended
up to August 15, 2020. Beyond the supportive therapy, up to now the best therapeutic approach for COVID-19 may be a three-step combination therapy, including remdesivir 100 mg/day (200 mg loading dose on first day) in the first stage of the disease, and combined
dexamethasone 6 mg/day plus baricitinib 4 mg/day to target the immune dysregulation triggered by the SARS-CoV-2 infection. |
|
Carter, MJ, Shankar-Hari, et al |
Intensive Care Med |
Review Literature| Revue de littérature |
|
|
|
The Role of Epidemiology in Informing United States Childhood Immunization
Policy and Practice |
Carter-Pokras, O, Hutchins, et al |
Ann Epidemiol |
Review Literature| Revue de littérature |
|
|
Chang, YY |
J Chin Polit Sci |
Review Literature| Revue de littérature |
|
|
|
Charles, A, Ingolf, et al |
Pharmacol Res |
Review Literature| Revue de littérature |
MA: DDI occurring in the course of anti-Covid-19 treatment and co-morbidities could lead to ADRs, increasing the risk
of hospitalization, prolonged time to recovery or death on extreme cases. COVID-19 patients with cardiometabolic diseases, chronic kidney disease and chronic obstructive pulmonary disease should be subjected to particular carefully clinical monitoring of adverse
events with a possibility of dose adjustment when necessary. |
|
|
Cheng, A, Caruso, et al |
Am Fam Physician |
Review Literature| Revue de littérature |
|
|
|
Chu, IY, Alam, et al |
J Travel Med |
Review Literature| Revue de littérature |
SR: Ovid-MEDLINE, EMBASE, PsycINFO, CNKI, and the WHO COVID-19 databases weres earched for publications from inception
to 9 April 2020. |
|
|
Neurological manifestations in COVID-19: a systematic review and meta-analysis |
Chua, TH, Xu, et al |
Brain Inj |
Review Literature| Revue de littérature |
SR-MA: systematic review of studies reporting neurological manifestations published between 1 December, 2019 and 11
May, 2020 was performed. Stroke is the most frequently reported neurological manifestation in COVID-19 and has the highest mortality rate. Neurological manifestations tend to develop one to two weeks after the onset of respiratory disease.
|
|
Cuicchi, D, Lazzarotto, et al |
Int J Colorectal Dis |
Review Literature| Revue de littérature |
|
|
|
Danthuluri, V, Grant, et al |
Ophthalmol Ther |
Review Literature| Revue de littérature |
|
|
|
The Hospitality Industry in the Face of the COVID-19 Pandemic: Current Topics and Research
Methods |
Davahli, MR, Karwowski, et al |
Int J Environ Res Public Health |
Review Literature| Revue de littérature |
|
|
The role of Kallikrein-kinin and Renin-Angiotensin systems in COVID-19 infection |
de Carvalho, PR, Sirois, et al |
Peptides |
Review Literature| Revue de littérature |
|
|
De Silva, AP, Niriella, et al |
Expert Rev Respir Med |
Review Literature| Revue de littérature |
|
|
|
Dong, Y, Dai, et al |
Signal Transduct Target Ther |
Review Literature| Revue de littérature |
|
|
|
Ebrahimi, N, Aslani, et al |
Int Immunopharmacol |
Review Literature| Revue de littérature |
|
|
|
Ehsani, S |
Biol Direct |
Review Literature| Revue de littérature |
|
|
|
NMR as a "Gold Standard" Method in Drug Design and Discovery |
Emwas, AH, Szczepski, et al |
Molecules |
Review Literature| Revue de littérature |
|
|
Beyond a Hashtag: Strategies to Move Toward a More Inclusive Physiatry Workforce |
Escalon, MX, De Mesa, et al |
Am J Phys Med Rehabil |
Review Literature| Revue de littérature |
|
|
Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2
disease |
Ferrario, CM, Ahmad, et al |
Clin Sci (Lond) |
Review Literature| Revue de littérature |
|
|
Unraveling the Role of ACE2, the Binding Receptor for SARS-CoV-2, in Inflammatory Bowel
Disease |
Ferreira-Duarte, M, Estevinho, et al |
Inflamm Bowel Dis |
Review Literature| Revue de littérature |
|
|
PMC7553007; Time to get ill: the intersection of viral infections, sex, and the
X chromosome |
Forsyth, KS, Anguera, et al |
Curr Opin Physiol |
Review Literature| Revue de littérature |
|
|
Fram, G, Wang, et al |
Curr Cardiol Rev |
Review Literature| Revue de littérature |
SR: PubMED, EMBASE, and Cochrane databases were searched for keywords derived from MeSH terms, prior to 4/9/2020. Millions
of hydroxychloroquine doses are prescribed annually. Prior to COVID-19 pandemic, cardiac complications attributed to hydroxychloroquine were uncommon.
|
|
|
Gąsecka, A, Borovac, et al |
Cardiovasc Drugs Ther |
Review Literature| Revue de littérature |
|
|
|
Gasmi, A, Tippairote, et al |
Mol Neurobiol |
Review Literature| Revue de littérature |
|
|
|
A Systematic Review and Meta-Analysis of Hospitalised Current Smokers and COVID-19 |
González-Rubio, J, Navarro-López, et al |
Int J Environ Res Public Health |
Review Literature| Revue de littérature |
SR-MA: search was made of the ISI Web of Science for the relevant works published until 28 April 2020. In conclusion,
the analysis of data from 18 studies shows a much lower percentage of hospitalised current smokers than expected. As more studies become available, this trend should be checked to obtain conclusive results and to explore, where appropriate, the underlying
mechanism of the severe progression and adverse outcomes of COVID-19. |
|
Behavioral strategies for reducing disease transmission in the workplace |
Gravina, N, Nastasi, et al |
J Appl Behav Anal |
Review Literature| Revue de littérature |
|
|
Guo, BM, Xu, et al |
Build Environ |
Review Literature| Revue de littérature |
|
|
|
Han, Y, Ma, et al |
J Perinat Med |
Review Literature| Revue de littérature |
SR-MA: Pregnant patients with COVID-19 most commonly presented with fever, cough, shortness of breath and dyspnea,
most of which possessed imaging manifestations. |
|
|
Emerging Challenges and Opportunities in the Evolution of Teleradiology |
Hanna, TN, Steenburg, et al |
AJR Am J Roentgenol |
Review Literature| Revue de littérature |
|
|
Hasan, SS, Kow, et al |
Expert Opin Pharmacother |
Review Literature| Revue de littérature |
|
|
|
Hoshina, T, Aonuma, et al |
Inflamm Regen |
Review Literature| Revue de littérature |
|
|
|
Hossein, H, Ali, et al |
Clin Transl Imaging |
Review Literature| Revue de littérature |
SR-MA: Searches were performed in Medline, Embase, Scopus, and Web of Science databases until the end of April 2020.
Simultaneous observation of GGO and other features of viral pneumonia in CT scan had optimum performance in detection of COVID-19. However, it is suggested to make the final diagnosis based on both CT scan and RT-PCR, as none of the two diagnostic modalities
are reliable alone. |
|
|
Considerations for the Management of Oncology Patients During the COVID-19 Pandemic |
Huang, J, Rohatgi, et al |
Oncology (Williston Park) |
Review Literature| Revue de littérature |
|
|
Jawhara, S |
Gut Pathog |
Review Literature| Revue de littérature |
|
|
|
Jayamohan, H, Lambert, et al |
Anal Bioanal Chem |
Review Literature| Revue de littérature |
|
|
|
ACE2 mouse models: a toolbox for cardiovascular and pulmonary research |
Jia, H, Yue, et al |
Nat Commun |
Review Literature| Revue de littérature |
|
|
PMC7553058; Seizure And COVID-19: Association and Review of Potential Mechanism |
Joseph, R, Narula, et al |
Neurol Psychiatry Brain Res |
Review Literature| Revue de littérature |
|
|
Kaushik, A, Gupta, et al |
Pediatr Infect Dis J |
Review Literature| Revue de littérature |
SR: PubMed, EMBASE, and CINAHL and preprint servers (BioRxiv.org and MedRxiv.org)were searched to retrieve all articles
published from January 1, 2020, to July 31, 2020. This systematic review delineates and summarizes clinical features, management, and outcomes of MIS-C associated with SARS-CoV-2 infection. Although most children required intensive care and immunomodulatory
therapies, favorable outcomes were reported in the majority with low-mortality rates. |
|
|
Khalil, A, Tazeddinova, et al |
Nat Prod Bioprospect |
Review Literature| Revue de littérature |
|
|
|
Koumpa, FS, Forde, et al |
BMJ Case Rep |
Review Literature| Revue de littérature |
|
|
|
The sensitivity and specificity of chest CT in the diagnosis
of COVID-19 |
Kovács, A, Palásti, et al |
Eur Radiol |
Review Literature| Revue de littérature |
|
|
Kritselis, M, Remick, et al |
Am J Pathol |
Review Literature| Revue de littérature |
|
|
|
Krusche, M, Mühlensiepen, et al |
Z Rheumatol |
Review Literature| Revue de littérature |
|
|
|
Neurological manifestations and comorbidity associated with COVID-19: an overview |
Kumar, M, Thakur, et al |
Neurol Sci |
Review Literature| Revue de littérature |
|
|
Larenas-Linnemann, D, Rodríguez-Pérez, et al |
World Allergy Organ J |
Review Literature| Revue de littérature |
|
|
|
Lepere, Philippe, Escarguel, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
|
|
|
Liu, Y, Lu, et al |
Expert Rev Anticancer Ther |
Review Literature| Revue de littérature |
SR-MA: PubMed, Cochrane Library, and Embase Ovid databases were searched for relevant articles published before July
31(st), 2020. Various demographic and clinical characteristics, such as male gender, advanced age, comorbidities, and symptoms, were identified as risk factors for mortality in patients with cancer and COVID-19. Our findings suggest recent anti-cancer treatments
do not increase mortality. |
|
|
Lu, DJ, Girgis, et al |
Adv Radiat Oncol |
Review Literature| Revue de littérature |
SR: searched the iOS App Store and Andriod Google Play using the words "cancer," "oncology," and "symptom tracker."
Only one app has been trialed for usability among cancer patients. CONCLUSION: While various symptom tracking apps are available, cancer-specific apps remain limited.
|
|
|
Luo, X, Zhou, et al |
Mil Med Res |
Review Literature| Revue de littérature |
|
|
|
A meta-analysis of 67 studies with presenting symptoms & laboratory tests of COVID-19 patients |
Mair, M, Singhavi, et al |
Laryngoscope |
Review Literature| Revue de littérature |
MA: PubMed, EMBASE and Ovid were searched to identify studies published between Dec-2019 and May-2020. The most commonly
experienced ENT symptom was cough followed by anosmia and dysguesia. Raised ESR and CRP with leukopenia and lymphopenia are common laboratory findings. Majority of the infected patients had abnormal computed tomography findings. COVID infection is less severe
in paediatric patients. |
|
Majid, U, Wasim, et al |
Public Underst Sci |
Review Literature| Revue de littérature |
ScR |
|
|
PMC7549424; Blockchain for COVID-19: Review, Opportunities, and a Trusted Tracking
System |
Marbouh, D, Abbasi, et al |
Arab J Sci Eng |
Review Literature| Revue de littérature |
|
|
Adapting hospital capacity to meet changing demands during the COVID-19 pandemic |
McCabe, R, Schmit, et al |
BMC Med |
Review Literature| Revue de littérature |
|
|
Giant cell arteritis and COVID-19: similarities and discriminators, a systematic literature
review |
Mehta, P, Sattui, et al |
J Rheumatol |
Review Literature| Revue de littérature |
SR: Two systematic literature reviews determined the frequency of clinical features of GCA and COVID-19 in published
reports. Overlapping features of GCA and COVID-19 include headache, fever, elevated CRP and cough. Jaw claudication, visual loss, platelet count and lymphocyte count may be more discriminatory.
|
|
Mercatelli, D, Holding, et al |
Brief Bioinform |
Review Literature| Revue de littérature |
|
|
|
How to communicate with families living in complete isolation |
Mistraletti, G, Gristina, et al |
BMJ Support Palliat Care |
Review Literature| Revue de littérature |
|
|
Mofijur, M, Fattah, et al |
Sustain Prod Consum |
Review Literature| Revue de littérature |
|
|
|
Deciphering the COVID-19 cytokine storm: Systematic review and meta-analysis |
Mulchandani, R, Lyngdoh, et al |
Eur J Clin Invest |
Review Literature| Revue de littérature |
SR-MA: Relevant studies were identified from PubMed, Embase, Web of Science, SCOPUS and pre-print servers. Severe COVID-19
is characterized by significantly increased levels of proinflammatory cytokines and reduced T-lymphocytes. Well-designed and adequately powered prospective studies are needed to amplify the current evidence and provide definitive answers to dilemmas regarding
timing and type of anti-COVID-19 therapy particularly in severe patients. |
|
PMC7556256; The effect of COVID-19 lockdown on acute type A aortic dissection:
insights from Bologna |
Murana, G, Folesani, et al |
JTCVS Tech |
Review Literature| Revue de littérature |
|
|
Nugroho, J, Wardhana, et al |
Clin Hemorheol Microcirc |
Review Literature| Revue de littérature |
MA: PubMed, Science Direct, Scopus, ProQuest, and MedRxiv databases. Elevated fibrinogen and FDP level on admission
were associated with an increase risk of poor outcome in COVID-19 patients. |
|
|
Do hydrogen peroxide mouthwashes have a virucidal effect? A systematic review |
Ortega, KL, Rech, et al |
J Hosp Infect |
Review Literature| Revue de littérature |
SR: The Cochrane, LILACS, PubMed, Scopus and EMBASE databases were searched. There is no scientific evidence supporting
the indication of hydrogen peroxide mouthwash for control of the viral load regarding SARS-CoV-2 or any other viruses in saliva. |
|
Parameswaran, Sathiyarajeswaran, Ms, et al |
medRxiv |
Review Literature| Revue de littérature |
|
|
|
PMC7552986; The role of inflammation in hypertension: novel concepts |
Patrick, DM, Van Beusecum, et al |
Curr Opin Physiol |
Review Literature| Revue de littérature |
|
|
SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates |
Poland, GA, Ovsyannikova, et al |
Lancet |
Review Literature| Revue de littérature |
|
|
Quan, C, Li, et al |
Clin Microbiol Rev |
Review Literature| Revue de littérature |
|
|
|
Undergraduate Neuroscience Education: Meeting the Challenges of the 21 st Century |
Ramirez, JJ |
Neurosci Lett |
Review Literature| Revue de littérature |
|
|
Synthesis and systematic review of reported neonatal SARS-CoV-2 infections |
Raschetti, R, Vivanti, et al |
Nat Commun |
Review Literature| Revue de littérature |
SR-MA: PubMed, The Cochrane Library, Web of Science, as well as BioXRiv and MedXRiv preprint archives were searched
until 2020/08/30. In conclusion, the synthesis of uncontrolled cases of neonatal SARS-CoV-2 infection shows that infections mainly occur postnatally through environmental exposure, although nearly 30% of infections may be acquired vertically. Approximately
half of the infected neonates develop clinically apparent COVID-19, which is often characterized by febrile status, features similar to those of older patients and favorable outcomes |
|
Rasheed, J, Jamil, et al |
Chaos Solitons Fractals |
Review Literature| Revue de littérature |
|
|
|
Rooney, CM, Moura, et al |
Curr Opin Gastroenterol |
Review Literature| Revue de littérature |
|
|
|
Saag, MS, Gandhi, et al |
Jama |
Review Literature| Revue de littérature |
|
|
|
PMC7545218; Biosensing based on field-effect transistors (FET): Recent progress
and challenges |
Sadighbayan, D, Hasanzadeh, et al |
Trends Analyt Chem |
Review Literature| Revue de littérature |
|
|
Pneumonia and respiratory infections in Down syndrome: A scoping review of the literature |
Santoro, SL, Chicoine, et al |
Am J Med Genet A |
Review Literature| Revue de littérature |
ScR: Using the National Library of Medicine database, PubMed, detailed literature searches weres completed. Pneumonia
and respiratory infections are more prevalent and more severe in individuals with Down syndrome compared to healthy controls through literature review, yet there are gaps in the literature regarding the etiology of pneumonia, the infectious organism, risk
factors for infection, and to guide options for prevention and screening.
|
|
Scribano, ML |
Dig Dis Sci |
Review Literature| Revue de littérature |
|
|
|
Evidence and speculations: vaccines and therapeutic options for COVID-19 pandemic |
Siddique, R, Bai, et al |
Hum Vaccin Immunother |
Review Literature| Revue de littérature |
|
|
Simmons, B, Wentzel, et al |
J Antimicrob Chemother |
Review Literature| Revue de littérature |
MA: Three clinical trials comparing sofosbuvir/daclatasvir-based regimens with a comparator in hospitalized COVID-19
patients were combined in a meta-analysis. Available evidence suggests that sofosbuvir/daclatasvir improves survival and clinical recovery in patients with moderate to severe COVID-19. However, the sample size for analysis was relatively small, one of the
trials was not randomized and the designs were not standardized. |
|
|
Skalny, AV, Rossi Lima, et al |
Food Chem Toxicol |
Review Literature| Revue de littérature |
|
|
|
Smondack, P, Gravier, et al |
Rev Mal Respir |
Review Literature| Revue de littérature |
|
|
|
Stasi, C, Fallani, et al |
Eur J Pharmacol |
Review Literature| Revue de littérature |
|
|
|
Pathogenesis-Directed Therapy of 2019 Novel Coronavirus Disease |
Stratton, CW, Tang, et al |
J Med Virol |
Review Literature| Revue de littérature |
|
|
The role of dysregulated immune responses in COVID-19 pathogenesis |
Tahaghoghi-Hajghorbani, S, Zafari, et al |
Virus Res |
Review Literature| Revue de littérature |
|
|
Ethics, pandemic and environment; looking at the future of low middle income countries |
Tanveer, F, Khalil, et al |
Int J Equity Health |
Review Literature| Revue de littérature |
|
|
How irritant are n-propanol and isopropanol? - A systematic review |
Tasar, R, Wiegand, et al |
Contact dermatitis |
Review Literature| Revue de littérature |
SR:review is based on a PubMed search of articles published between January 2000 and 2020. While recent studies indicate
a higher risk of skin irritation for n- and isopropanol than reported in the past, this risk still seems to be lower than that for frequent handwashing with detergents as proposed by some recommendations to prevent COVID-19 infections.
|
|
Food Insecurity and Pediatric Obesity: a Double Whammy in the Era of COVID-19 |
Tester, JM, Rosas, et al |
Curr Obes Rep |
Review Literature| Revue de littérature |
|
|
Tolchin, B, Hull, et al |
J Med Ethics |
Review Literature| Revue de littérature |
|
|
|
FebriDx point-of-care test in patients with suspected
COVID-19: a pooled diagnostic accuracy study |
Urwin, SamuelG, Lendrem, et al |
medRxiv |
Review Literature| Revue de littérature |
|
|
Vandenberg, O, Martiny, et al |
Nat Rev Microbiol |
Review Literature| Revue de littérature |
|
|
|
PMC7550104; Process Assessment, Integration and Optimisation: The Path towards
Cleaner Production |
Varbanov, PS, Jia, et al |
J Clean Prod |
Review Literature| Revue de littérature |
|
|
Vergara, J, Starmer, et al |
JAMA Otolaryngol Head Neck Surg |
Review Literature| Revue de littérature |
|
|
|
Wang, X, Sahu, et al |
J Thromb Thrombolysis |
Review Literature| Revue de littérature |
|
|
|
PMC7548076; Incubation period of SARS-CoV-2: A systematic review and meta-analysis |
Wassie, GT, Azene, et al |
Curr Ther Res Clin Exp |
Review Literature| Revue de littérature |
SR-MA: PubMed, Google Scholar, EMBASE, and the World Health Organization's HINARI portal were seached. The pooled
average incubation period of SARS-CoV-2 was about six days. The longest incubation period was observed in China.
|
|
Wendt, S, Abdullah, et al |
Surv Ophthalmol |
Review Literature| Revue de littérature |
|
|
|
The undiscovered potential of essential oils for treating SARS-CoV-2 (COVID-
19) |
Wilkin, PJ, Al-Yozbaki, et al |
Curr Pharm Des |
Review Literature| Revue de littérature |
|
|
Wirth, FN, Johns, et al |
JMIR Mhealth Uhealth |
Review Literature| Revue de littérature |
ScR: searched PubMed and IEEE Xplore. We see a large potential for future solutions supporting multiple use cases
by combining different technologies (e.g. Bluetooth and GPS). For this to be successful, however, adequate privacy-protection measures must be implemented. |
|
|
Alveolar cells under mechanical stressed niche: critical contributors to pulmonary
fibrosis |
Yang, J, Pan, et al |
Mol Med |
Review Literature| Revue de littérature |
|
|
Policies Tackling the COVID-19 Pandemic: A Sociopolitical Perspective from Taiwan |
Yeh, MJ, Cheng, et al |
Health Secur |
Review Literature| Revue de littérature |
|
|
Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies |
Yuan, M, Liu, et al |
Biochem Biophys Res Commun |
Review Literature| Revue de littérature |
|
|
Biomedical Science to Tackle the COVID-19 Pandemic: Current Status and Future Perspectives |
Zamora-Ledezma, C, C, et al |
Molecules |
Review Literature| Revue de littérature |
|
|
Zhang, Jingxue, Zhou, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
SR-MA: searched PubMed, Embase, Web of Science, Cochrane library, SinoMed, China National Knowledge Infrastructure,
WanFang Database between 2003 and 2020. For treating against SARS-CoV-2, LPV/r and high-dose CQ showed OAE issues, while no significant safety problems among safety outcomes are found in remdesivir and TCM. Traditional Chinese Medicine may be an alternative
treatment with less safety issue for SARS-CoV patients. |
|
|
Zhang, P, Shi, et al |
Immunogenetics |
Review Literature| Revue de littérature |
|
|
|
Tocilizumab for treating COVID-19: a systemic review and meta-analysis of retrospective
studies |
Zhao, M, Lu, et al |
Eur J Clin Pharmacol |
Review Literature| Revue de littérature |
SR-MA: comprehensive search was conducted (up to September 27, 2020). Tocilizumab may have potential effectiveness
to treat COVID-19 according to the results of this study. |
|
Zortea, TC, Brenna, et al |
Crisis |
Review Literature| Revue de littérature |
|
|
|
A, AS, Srivastava, et al |
Biology (Basel) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Abbasi, J |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Engineered nanomaterials as fighters against SARS-CoV-2: The way to control and
treat pandemics |
Abd Elkodous, M, El-Sayyad, et al |
Environ Sci Pollut Res Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7547825; Role of micronutrients in the management of COVID-19 |
AbdAllah, M, Elarab, et al |
New Microbes New Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Trends in Hospitalizations for Asthma During the COVID-19 Outbreak in Japan |
Abe, K, Miyawaki, et al |
J Allergy Clin Immunol Pract |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Analgesia and Sedation Strategies in Mechanically Ventilated Adults with COVID-19 COVID-19 |
Adams, CD, Altshuler, et al |
Pharmacotherapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Adepoju, Paul |
The Lancet Digital Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Diversifying online rheumatology education options in the era of COVID-19 |
Ahmed, S, Zimba, et al |
Clin Rheumatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Alamarat, Z, Pérez, et al |
Pediatr Infect Dis J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
[The 2030 Agenda for Sustainable Development - an important opportunity
to improve global health] |
Alfvén, T, Ekman, et al |
Lakartidningen |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7556223; COVID-19: Searching for a Little Hope in Adversity-The Sub-Saharan
Experience |
Ali, SK |
J Pain Symptom Manage |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Alicja Jereczek-Fossa, B, Pepa, et al |
Radiother Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Alla, F, Berlin, et al |
Can J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Altable, M, Moisés de la Serna, et al |
J Neuropathol Exp Neurol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Please Wait for the Host to Start This Meeting: A Push for H.R. 3235 Amid COVID-19 |
Anderson, K, Terry, et al |
Genet Test Mol Biomarkers |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Anderson, S, Haeder, et al |
J Adolesc Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Andrijevic, M, Schleussner, et al |
Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hospital transfers across U.S. regions to address the "space" shortage in a pandemic:
a public good |
Anesi, GL |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Coronavirus disease and dermatology: current and future challenges |
Annunziata, MC, Megna, et al |
G Ital Dermatol Venereol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Arena, R, Lavie, et al |
Prog Cardiovasc Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Asfaw, EK, Guo, et al |
Health Educ Behav |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Asrani, P, Hassan, et al |
Mol Cell Biochem |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Athanasiou, A, Spartalis, et al |
Ann Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with
nicotinamide? |
Badawy, AA |
Biosci Rep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Baines, P, Draper, et al |
J Med Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Comment on "Lung Transplantation for Elderly Patients With End-stage COVID-19
Pneumonia" |
Baquero, A, Beyda, et al |
Ann Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ending support for medical organisations puts the world at risk |
Baranchuk, Adrian, Liprandi, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Attenuating COVID-19 infection and inflammation: Lessons from asthma |
Bardin, PG, Johnston, et al |
Respirology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Angioedema in African Americans Patients Hospitalized for COVID-19 |
Batarseh, E, Kersten, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Baweja, R, Verma, et al |
Prim Care Companion CNS Disord |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Comment on "SARS-CoV-2 is Present in Peritoneal Fluid in COVID-19 Patients" |
Beaux, AC, Pawlak, et al |
Ann Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Parents experiencing NICU visit restrictions due to COVID-19 pandemic |
Bembich, S, Tripani, et al |
Acta Paediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Benova, L, Sarkar, et al |
Sex Reprod Health Matters |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Analysis of Commercial Hand Sanitisers amid CoViD-19: Are We Getting the Products
that We Need? |
Berardi, A, Cenci-Goga, et al |
AAPS PharmSciTech |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Bernard, R, Bowsher, et al |
Am J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Besson, J, McNamara, et al |
J Med Radiat Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Editorial: Effects of the COVID-19 pandemic on child and adolescent mental health |
Bhatia, R |
Curr Opin Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19, children and non-communicable diseases: translating evidence into
action |
Bhutta, ZA, Hauerslev, et al |
Arch Dis Child |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7553008; Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS
modulator |
Bian, J, Li, et al |
Acta Pharm Sin B |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Birch, S |
SSM Popul Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Booth, T, Murray, et al |
Alzheimers Dement |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Borisova, T, Komisarenko, et al |
Environ Sci Pollut Res Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bossi, AC, Forloni, et al |
Diabetes Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Boyd, RheaW, Krieger, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Psychological Resilience of Healthcare Professionals During COVID-19 Pandemic |
Bozdağ, F, Ergün, et al |
Psychol Rep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Brierley, J, Larcher, et al |
Postgrad Med J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Long-term health-related quality of life concerns related to the COVID-19 pandemic:
a call to action |
Bryson, WJ |
Qual Life Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Use of adenovirus type-5 vectored vaccines: a cautionary tale |
Buchbinder, SusanP, McElrath, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Butler, M, Pollak, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 Pandemic: The Role of EMS Physicians in a Community Response Effort |
Cabañas, JG, Williams, et al |
Prehosp Emerg Care |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cai, Z, Greene, et al |
Antibodies (Basel) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 OUTCOMES IN PATIENTS WITH UNCONTROLLED HIV-1 INFECTION |
Calza, L, Bon, et al |
J Acquir Immune Defic Syndr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
SARS-CoV-2 virus infection: Targets and antiviral pharmacological strategies |
Campos, DMO, Fulco, et al |
J Evid Based Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Severe COVID-19-related encephalitis can respond to immunotherapy |
Cao, A, Rohaut, et al |
Brain |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Coronavirus, Capitalism in Crisis and the Perversity of Public Health in Bolsonaro's
Brazil |
Carnut, L, Mendes, et al |
Int J Health Serv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Casciato, S, Paolini, et al |
Neurol Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Castagnetto, JM, Segovia-Juarez, et al |
High Alt Med Biol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cavalcante, MB, Sarno, et al |
Arch Gynecol Obstet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A commentary on podiatry during the Covid-19 pandemic : Podiatry during the Covid-19
pandemic |
Chadwick, P, Ambrose, et al |
J Foot Ankle Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
How confidence in health care systems affects mobility and compliance during
the COVID-19 pandemic |
Chan, HF, Brumpton, et al |
PLoS One |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Chandrakanth, HV, Rani, et al |
Med Leg J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chang, AJ, Croix, et al |
Pediatr Infect Dis J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Chaturvedi, SK |
Pain |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Distance learning in the COVID-19 era: Comparison of student and faculty perceptions |
Chen, E, Kristie, et al |
J Dent Educ |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Imaging Evaluation of Coronavirus Disease (COVID-19) Pneumonia in Pregnant Women |
Chen, L, Liang, et al |
AJR Am J Roentgenol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A painful lesson from the COVID-19 pandemic: the need for broad-spectrum, host-directed
antivirals |
Chitalia, VC, Munawar, et al |
J Transl Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Role of Genetic Variants and Gene Expression in the Susceptibility and Severity
of COVID-19 |
Choudhary, S, Sreenivasulu, et al |
Ann Lab Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Role of multimodality imaging in evaluation of cardiovascular involvement in COVID-19 |
Citro, R, Pontone, et al |
Trends Cardiovasc Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
RE: How the Coronavirus Disease-2019 May Improve Care: Rethinking Cervical Cancer Prevention |
Clark, CR, Haas, et al |
J Natl Cancer Inst |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Clarke, SK, Kumar, et al |
J Immigr Minor Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
ECCO2R with cytokine filtering in COVID-19 patients: Who wants to go down this road? |
Condello, I, Mastroroberto, et al |
Int J Artif Organs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Transmission of SARS-CoV-2 via Contaminated Surfaces: What is to be Done? |
Conover, CS |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The BMJ Interview: Tim Spector on how data can arm us against covid-19 |
Coombes, R |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cota, LB, Pedrosa, et al |
Curr Drug Targets |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7547823; Stroke in a young adult with mild COVID-19 suggesting endotheliitis |
Crippa, S, Kägi, et al |
New Microbes New Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Fixing England's COVID-19 response: learning from international experience |
Crozier, A, McKee, et al |
J R Soc Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Magnet® Site Visit: Going Virtual in Response to COVID-19 |
Curto, C, Martin, et al |
J Nurs Adm |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Challenges in management of idiopathic granulomatous mastitis during the pandemic of COVID-19 |
Dağ, A, Edizsoy, et al |
Breast J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Dai, R, Spector, et al |
Alzheimers Dement (Amst) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
D'Ambrosi, R, Biazzo, et al |
Hss j |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Darwin, KH |
EMBO Rep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Favipiravir as an antiviral agent in COVID-19: same script, different cast? |
Dauby, N |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 and African immigrants in North Africa; A hidden pandemic in a vulnerable setting |
Daw, MA, El-Bouzedi, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The double-edged sword of SARS-CoV-2 vs. market economy: a perspective of Brazilian
dental providers |
de Arruda, JAA, Silva, et al |
J Stomatol Oral Maxillofac Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Scientific Ambiguity in the Time of Coronavirus Disease 2019 |
de la Oliva, P, Rodriguez-Rubio, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
de Lannoy, L, Rhodes, et al |
Can J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90s? |
De Waele, JJ, Derde, et al |
Intensive Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Virtual Consultations for Cleft-Craniofacial Conditions Amid the COVID-19 Pandemic
and Beyond |
Denadai, R, Seo, et al |
J Craniofac Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
On redesigning public health in Québec: lessons learned from the pandemic |
Denis, JL, Potvin, et al |
Can J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Di Vincenzo, A, Rossato, et al |
Pediatr Infect Dis J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Díaz-Garzón, J, Oliver, et al |
Biochem Med (Zagreb) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Din, M, Asghar, et al |
Public health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Doroshow, JH, Prindiville, et al |
J Natl Cancer Inst |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Dua, AB, Kilian, et al |
Clin Rheumatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19: Eli Lilly pauses antibody trial for safety reasons |
Dyer, O |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Echternach, M, Gantner, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ehsani, JP |
J Adolesc Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Grief Before and During the COVID-19 Pandemic: Multiple Group Comparisons |
Eisma, MC, Tamminga, et al |
J Pain Symptom Manage |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Comment on "Gastrointestinal Complications in Critically Ill Patients With COVID-19":
An Update |
El Moheb, M, Christensen, et al |
Ann Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lymphocyte counts and the risk of COVID-19 in people with MS |
Evangelou, N, Garjani, et al |
Mult Scler |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 Highlights the Policy Barriers and Complexities of Postpartum
Sterilization |
Evans, ML, Qasba, et al |
Contraception |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Access to data from clinical trials in the COVID-19 crisis: open, flexible,
and time-sensitive |
Ewers, M, Ioannidis, et al |
J Clin Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ferrara, F, Porta, et al |
Ir J Med Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 in Italian patients with rheumatic autoimmune systemic diseases |
Ferri, C, Giuggioli, et al |
Ann Rheum Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Debate: Mental health, social crisis and the COVID-19 pandemic in Chile |
Fischman, P, Irarrazaval, et al |
Child Adolesc Ment Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cranial Nerve III Palsy in the setting of COVID 19 Infection |
Fitzpatrick, JC, Comstock, et al |
J Neuroophthalmol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Proposed CoVid-19 Treatments: Lessons from the Inflammation & Cardiovascular Disease Theory |
Fleming, RichardM, Fleming, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Földi, M, Farkas, et al |
Obes Rev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Fontenelle-Tereshchuk, D |
Interchange (Tor : 1984) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Forrest, JI, Rayner, et al |
Infect Dis Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Unique needs of childhood cancer survivors during the COVID-19 pandemic |
Forster, VJ, Schulte, et al |
Support Care Cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Foust, AM, Winant, et al |
J Thorac Imaging |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Franceschini, G, Sanchez, et al |
Breast J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Horticulture in Queensland Australia, COVID-19 Response. It Hasn't All Been
Bad on Reflection |
Franklin, RC, O'Sullivan, et al |
J Agromedicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Fu, D, Yu, et al |
Ann Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Gagliotti, C, Buttazzi, et al |
Infect Dis (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cardiology on the cutting edge: updates from the European Society of Cardiology
(ESC) Congress 2020 |
Gallego-Colon, E, Bonaventura, et al |
BMC Cardiovasc Disord |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Garg, P, Sangam, et al |
Nano Today |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Reply to: Respiratory Drive Measurements do not Signify Conjectural P-SILI |
Gattinoni, L, Marini, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gay, HC, Sinha, et al |
ESC Heart Fail |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Gedela, K, Januraga, et al |
Asia Pac J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
2020: The Year of the Nurse, COVID-19, and Systemic Discrimination and Racism |
Gennaro, S |
J Nurs Scholarsh |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Germain, S, Yong, et al |
Fem Leg Stud |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Gilliam, WS, Malik, et al |
Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Indigenous people and the COVID-19 pandemic: the tip of an iceberg of social and
economic inequities |
Goha, A, Mezue, et al |
J Epidemiol Community Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Spanish 1918 Flu and the COVID-19 Disease: The Art of Remembering and Foreshadowing
Pandemics |
Goldstein, JL |
Cell |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Gomides, A, Ferreira, et al |
JMIR Res Protoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Goodman, JL, Grabenstein, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PEG tube placement in COVID-19 patients: A multidisciplinary approach |
Goyal, H, Perisetti, et al |
Dig Endosc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Green, C, Morrison, et al |
Neurology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Grussu, P, Quatraro, et al |
J Reprod Infant Psychol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Gurwith, M, Condit, et al |
Vaccine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Barriers to Optimizing Teledentistry During COVID-19 Pandemic |
Haider, MM, Allana, et al |
Asia Pac J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ham, C |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hamad, L, Kreidieh, et al |
Am J Med Genet A |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Hambleton, A, Le Grange, et al |
J Eat Disord |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 infection in febrile neutropenic pediatric hematology oncology patients |
Hamdy, R, El-Mahallawy, et al |
Pediatr Blood Cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hyperoxia and modulation of pulmonary vascular and immune responses in COVID-19 |
Hanidziar, D, Robson, et al |
Am J Physiol Lung Cell Mol Physiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hayes, S |
J Hosp Leis Sport Tour Educ |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Response to "Registry reports in COVID-19 patients: juggling with big data, poor
data, and no data" |
Hazzan, M, Caillard, et al |
Kidney Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Time to address the spatiotemporal uncertainties in COVID-19 research: Concerns
and challenges |
Helbich, M, Mute Browning, et al |
Sci Total Environ |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hemida, MG, Ali, et al |
Epidemiol Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
From COVID-19 to clot: the involvement of the complement system |
Hendaus, MA, Jomha, et al |
J Biomol Struct Dyn |
Commentary/Editorial| Commentaire/Éditorial |
|
|
What are protective antibody responses to pandemic SARS-CoV-2? |
Henderson, JP |
J Clin Invest |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Hoang, BX, Shaw, et al |
J Glob Antimicrob Resist |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 in patients with cancer: managing a pandemic within a pandemic |
Horn, L, Garassino, et al |
Nat Rev Clin Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 in Dialysis Patients: Outlasting and Outsmarting a Pandemic |
Hsu, CM, Weiner, et al |
Kidney Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: Shielding may be reintroduced for vulnerable people in highest risk areas |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: Three tier alert system takes effect across England |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: England's test and trace system records worst weekly performance since launch |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Incorvaia, C, Ridolo, et al |
Ann Am Thorac Soc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Iwasaki, A, Omer, et al |
Cell |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Changes in cancer preventive behaviours, screening and diagnosis during COVID-19 |
Janda, M, Paul, et al |
Psychooncology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Jansson-Knodell, C, Bhavsar-Burke, et al |
Clin Gastroenterol Hepatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Janszky, J, Bóné, et al |
Orv Hetil |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Doctors during the COVID-19 pandemic: what are their duties and what is owed
to them? |
Johnson, SB, Butcher, et al |
J Med Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Once again the world and our profession was in were Covid-19… |
Jongbloed-Zoet, C |
Int J Dent Hyg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7550060; [Cardiac involvement in COVID-19: does echocardiography matter?] |
Jorge-Pérez, P, Durán-Cambra, et al |
Rev Esp Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Post COVID-19 bronchiectasis: a potential epidemic within a pandemic |
José, RJ, Manuel, et al |
Expert Rev Respir Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19: The Current Situation in the Democratic Republic of Congo |
Juma, CA, Mushabaa, et al |
Am J Trop Med Hyg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kadambari, S, Abo, et al |
Pediatr Infect Dis J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kaiper-Marquez, A, Wolfe, et al |
Int Rev Educ |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kaiser, J |
Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Vaccines in the Time of COVID-19: How Government
and Businesses Can Help Us Reach Herd Immunity |
Kaminer, Debbie |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Non-invasive Thoracic Impedance Changes in COVID-19 Pulmonary Infection |
Kapur, S, Sweeney, et al |
J Cardiovasc Transl Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Karapanayiotides, T, Geka, et al |
Brain |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
May Mangafodipir or Other SOD Mimetics Contribute to Better Care in COVID-19 Patients? |
Karlsson, JOG, Jynge, et al |
Antioxidants (Basel) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kaser, A |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Katz, SE, Spencer, et al |
J Pediatric Infect Dis Soc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kaur, M, Devi, et al |
Pharm Nanotechnol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kaushal, V, Srivastava, et al |
Int J Hosp Manag |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Semen Does Not Cause Additional Risk for SARS-CoV-2 Transmission during Sexual Contact |
Kayaaslan, B, Korukluoglu, et al |
Urol Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kellogg, C, Equils, et al |
Hum Vaccin Immunother |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Immediate and Long-Term Implications of the COVID-19 Pandemic for People With Disabilities |
Kendall, E, Ehrlich, et al |
Am J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kerr, D, Warshaw, et al |
J Diabetes Sci Technol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Khan, S, Chen, et al |
J Am Soc Nephrol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Bracing for the Storm: One Health Care System's Planning for the COVID-19 Surge |
Kim, CS, Meo, et al |
Jt Comm J Qual Patient Saf |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kim, JH |
J Exp Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kisilevsky, E, Margolin, et al |
Can J Ophthalmol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Klavinskis, L, Liu, et al |
Emerg Microbes Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Klimek, L, Jutel, et al |
Allergy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Prochlorperazine for nausea and vomiting accompanied COVID-19 |
Kow, CS, Hasan, et al |
J Gastroenterol Hepatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kremer, EJ |
Mol Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kucharski, AJ, Funk, et al |
PLoS Biol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kumar, H, Azad, et al |
Environ Dev Sustain |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7546995; Repurposing Hepatitis C Direct -acting antivirals against COVID-19 |
Kumar, P, Kulkarni, et al |
J Clin Exp Hepatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7549337; Impact of Covid-19 on Hematological Practice: Challenges and Opportunities |
Kumar, R |
Indian J Hematol Blood Transfus |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Important Concerns Over SARS-CoV-2 Infection in Children With Cancer-Reply |
Kung, AL, Mauguen, et al |
JAMA Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kurth, T, Brinks, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Laine, C, Cotton, et al |
Ann Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lauper, K, Bijlsma, et al |
Ann Rheum Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Integrated clinical role of echocardiography in patients with COVID-19 disease |
Lazzeri, C, Bonizzoli, et al |
Heart |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Postapproval Vaccine Safety Surveillance for COVID-19 Vaccines in the US |
Lee, GM, Romero, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Impact of Coronavirus disease 2019 on organ donation and transplantation in France |
Legeai, C, Malaquin, et al |
Transpl Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lemyze, M, Mascot, et al |
Clin Nutr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Healthy Food Retail during the COVID-19 Pandemic: Challenges and Future Directions |
Leone, LA, Fleischhacker, et al |
Int J Environ Res Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lessler, J |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Li, WQ, Li, et al |
Pers Individ Dif |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lichtenauer, M, Prinz, et al |
Herz |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Aging in Brazil and the novel coronavirus: the ELSI-COVID-19 initiative |
Lima-Costa, M |
Cad Saude Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Limb, M |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Linden, E |
J Air Transp Manag |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lindholm, E, Tønnessen, et al |
Tidsskr Nor Laegeforen |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
D-dimer measurement in COVID-19: Silver bullet or clinical distraction? |
Lippi, G, Favaloro, et al |
Thromb Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Diffuse Hemorrhagic Enterocolitis in the setting of 2019 Coronavirus |
Lizaola-Mayo, B, Salomao, et al |
Clin Gastroenterol Hepatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lessons Learned From a Mental Health Hospital: Managing COVID-19 |
Loewenstein, K, Saito, et al |
J Nurs Adm |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Loman, M, Vogt, et al |
Child Neuropsychol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Response to letter 'Lymphocyte counts and the risk of COVID-19 in people with MS' |
Loonstra, FC, van Kempen, et al |
Mult Scler |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The human coronavirus receptor ANPEP (CD13) is overexpressed in Parkinson's disease |
Lowes, H, Robertson, et al |
Mov Disord |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Effect of COVID-19 pandemic on treatment of Type 1 diabetes in children |
Ludvigsson, J |
Acta Paediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Luercio, M, Ward, et al |
J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lyon, D |
Oncol Nurs Forum |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Upholding morality and honesty in global scientific research during the coronavirus
disease pandemic |
Lyu, P, Wang, et al |
Chin Med J (Engl) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mackey, RM, Yeow, et al |
Clin Gerontol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19: Johnson and Johnson vaccine trial is paused because of unexplained illness in
participant |
Mahase, E |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: Experts recommend two week circuit break to reduce transmission in the UK |
Mahase, E |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Malin, JJ, Spinner, et al |
Infection |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Malin, JJ, Suárez, et al |
Clin Microbiol Rev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Resuming ultrasound activity after the acute phase of the COVID-19 pandemic |
Marín Serrano, E, Álvarez-Higueras, et al |
Rev Esp Enferm Dig |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Performance of Prediction Models for Covid-19: The Caudine Forks of the External
Validation |
Martin, GP, Sperrin, et al |
Eur Respir J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Clinical management of Lupus patients during the COVID-19 pandemic |
Mason, A, Rose, et al |
Lupus |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7556251; [Covid-19 crisis and National Academy of Medicine] |
Mattei, JF, Buisson, et al |
Bull Acad Natl Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Accepting randomness in medical school admissions: The case for a lottery |
Mazer, BL |
Med Teach |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Survival analysis of treatment efficacy in comparative COVID-19 studies |
McCaw, ZR, Tian, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Learning in the Time of COVID-19: a Preclinical Student's Perspective |
McClements, EA |
Acad Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Capturing the wisdom of the crowd: health professions' educators meet at a virtual
world café |
McKimm, J, Ramani, et al |
Perspect Med Educ |
Commentary/Editorial| Commentaire/Éditorial |
|
|
McLean, M, Abuelaish, et al |
Med Confl Surviv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Melmed, GY, Rubin, et al |
Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Obesity and COVID-19: A jigsaw puzzle with still missing pieces |
Michalakis, K, Panagiotou, et al |
Clin Obes |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Micke, O, Vormann, et al |
J Am Coll Nutr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Miralles, O, Sanchez-Rodriguez, et al |
Eur Geriatr Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Comment on: SARS-CoV-2 is Present in Peritoneal Fluid in COVID-19 Patients |
Mishra, R, Shrivastava, et al |
Ann Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Miyazawa, M |
Inflamm Regen |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Acute COVID-19 and the Incidence of Ischemic Stroke and Acute Myocardial
Infarction |
Modin, D, Claggett, et al |
Circulation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mohamed Ahmed, E, Chen, et al |
J Card Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mohamed, MFH |
Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 pandemic and health anxiety among nurses of intensive care units |
Mokhtari, R, Moayedi, et al |
Int J Ment Health Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Coronavirus disease 2019 and slums in the Global South: lessons from Medellín (Colombia) |
Molina-Betancur, J, Martínez-Herrera, et al |
Glob Health Promot |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Momohara, S, Mizumura, et al |
Mod Rheumatol Case Rep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Surgical Revascularization With Cardiopulmonary Bypass on a Patient With Severe COVID-19 |
Montandrau, O, Arana, et al |
Semin Cardiothorac Vasc Anesth |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Morana, D |
Minerva Cardioangiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Morgante, G, Troìa, et al |
J Steroid Biochem Mol Biol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Morice, AH |
Eur Respir J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Road Less Traveled: SARS-CoV-2 and Cell-Mediated Immunity |
Morris, KV |
Mol Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7546204; High Tech, High Risk: Tech Ethics Lessons for the COVID-19 Pandemic
Response |
Moss, E, Metcalf, et al |
Patterns (N Y) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mota, Ó |
Acta Med Port |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7385816; My vascular diary on coronavirus disease-19 pandemic and ideal health
care settings |
Mousa, AY, Nanjundappa, et al |
J Vasc Surg Venous Lymphat Disord |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Suicide Prevention in the COVID-19 Era: Transforming Threat Into Opportunity |
Moutier, C |
JAMA Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mukherjee, S |
Cell |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mycko, MP |
Neurol Neurochir Pol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Producing and using timely comparative evidence on drugs: lessons from clinical trials for
covid-19 |
Naci, H, Kesselheim, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Perspectives on mechanistic implications of ROS inducers for targeting viral
infections |
Nadhan, R, Patra, et al |
Eur J Pharmacol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nadim, MK, Forni, et al |
Nat Rev Nephrol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nanda, P, Lewis, et al |
Sex Reprod Health Matters |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Virtual and essential - adolescent SRHR in the time of COVID-19 |
Nanda, P, Tandon, et al |
Sex Reprod Health Matters |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Navia, A, Tejos, et al |
Aesthetic Plast Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Jet Fans in the Underground Car Parks and Virus Transmission |
Nazari, Ata, Jafari, et al |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Newman, L, Winn, et al |
Clin Cancer Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nielsen, L |
Bioethics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Africa Needs a New Public Health Order to Tackle Infectious Disease Threats |
Nkengasong, JN, Tessema, et al |
Cell |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Núñez-Delgado, A |
Curr Opin Environ Sci Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nunneley, CE, Fishman, et al |
Clin Teach |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Oaklander, AL |
Pain |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Odonkor, CA, Sholas, et al |
Am J Phys Med Rehabil |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19 pandemic is magnifying healthcare inequalities, says England's regulator |
O'Dowd, A |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Omer, SB, Yildirim, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Integrated clinical role of echocardiography in patients with COVID-19 |
Pagnesi, M, Baldetti, et al |
Heart |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Paice, JA, Wholihan, et al |
J Hosp Palliat Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 And Type 2 Diabetes Mellitus: Hydroxychloroquine May Be The Holy
Grail |
Pal, R, Bhasin, et al |
Infect Disord Drug Targets |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nutritional support for critically ill patients with COVID-19: New strategy for
a new disease? |
Pardo, E, Constantin, et al |
Anaesth Crit Care Pain Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Return to normal operations: COVID-19 mitigation strategies for workplaces |
Parker, J, Boles, et al |
Toxicol Ind Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Connecting with Families through Virtual Perinatal Education during the COVID-19
Pandemic |
Pasadino, F, DeMarco, et al |
MCN Am J Matern Child Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Patel, MM, Jackson, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
An Opportunity for Improvement: iPLEDGE Policy Changes During the Coronavirus Pandemic |
Pathoulas, JT, Farah, et al |
Dermatol Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Patoulias, D, Papadopoulos, et al |
Diabetes Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7283813; A Real-World Evidence Framework for Optimizing Dosing in All Patients With COVID-19 |
Peck, RW, Weiner, et al |
Clin Pharmacol Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pedreira Massa, JL |
Rev Esp Salud Publica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Spatiotemporal dynamics of the COVID-19 pandemic in the arctic: early data and
emerging trends |
Petrov, AN, Welford, et al |
Int J Circumpolar Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
[MMR vaccination at UNIL and EPFL : Lausanne medical students get involved] |
Porret, R, Ishii, et al |
Rev Med Suisse |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Can Low-Intensity Pulsed Ultrasound Treat Discrete Pulmonary Lesions in Patients With COVID-19? |
Prada, F, Cogliati, et al |
J Ultrasound Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A Lung Cancer Patient with Dyspnea: Diagnostic Difficulties during the COVID-19
Pandemic |
Pruis, MA, Hussain, et al |
Cancer Cell |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Psihogios, AM, Stiles-Shields, et al |
J Pediatr Psychol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Colon cancer detection and prevention in the age of COVID-19 |
Quigley, EMM |
Curr Opin Gastroenterol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Virtual HIV pre-exposure prophylaxis outpatient service in the era of COVID-19 |
Quirke, S, Quinn, et al |
Int J STD AIDS |
Commentary/Editorial| Commentaire/Éditorial |
|
|
CEASE approach for combating COVID-19, AMR and future microbial threats |
Rahube, T |
Can J Microbiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rajan, S, Bebawy, et al |
J Neurosurg Anesthesiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rakotosamimanana, Niaina, Randrianirina, et al |
The Lancet Global Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Rappuoli, R |
Cell |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Psychoanalysis in combatting mass non-adherence to medical advice |
Ratner, Austin, Gandhi, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Reddy, GB, Greif, et al |
Hss j |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Debate: Remote learning during COVID-19 for children with high functioning autism spectrum
disorder |
Reicher, D |
Child Adolesc Ment Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Reitinger, J, Jain, et al |
Eye (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19: Extend visas for international staff to help fight second wave, health unions
urge |
Rimmer, A |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rios, CI, Cassatt, et al |
Radiat Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Racial and Socioeconomic Disparities in Access to Telehealth |
Rivera, V, Aldridge, et al |
J Am Geriatr Soc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Candida auris: a latent threat to critically ill patients with COVID-19 |
Rodriguez, JY, Le Pape, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19: Clouds Over the Antimicrobial Resistance Landscape |
Rodríguez-Álvarez, M, López-Vidal, et al |
Arch Med Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The impact of COVID-19 on burn care at a major regional burn centre |
Rogers, AD, Cartotto, et al |
J Burn Care Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 is not a driver of clinically significant viral wheeze and asthma |
Roland, D, Teo, et al |
Arch Dis Child |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The COVID-19 reset: lessons from the pandemic on Burnout and the Practice of Surgery |
Romanelli, J, Gee, et al |
Surg Endosc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 vaccine and boosted immunity: Nothing ad interim to do? |
Roncati, L, Vadalà, et al |
Vaccine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Effect of HLA-B27 on Susceptibility and Severity of Covid-19 |
Rosenbaum, JT, Hamilton, et al |
J Rheumatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Roten, FM, Beran, et al |
Notf Rett Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Acute Kidney Injury in COVID-19: Another Challenge for Nephrology |
Rudnick, MR, Hilburg, et al |
Am J Nephrol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ruiz Cantero, MT |
Gac Sanit |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Russell, J |
Vet Rec |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Ryan, C, Sabourin, et al |
Can J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sachdeva, S, Desai, et al |
SN Compr Clin Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Saibeni, S, Scucchi, et al |
United European Gastroenterol J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Salali, GD, Uysal, et al |
Psychol Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Samies, NL, Yarbrough, et al |
J Pediatric Infect Dis Soc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Don't let COVID stop your fieldwork: three tips for successful collaborations |
Sampson, C, Vamosi, et al |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sanguedolce, F, Zanelli, et al |
Panminerva Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sanguineti, F, Garot, et al |
Ann Cardiol Angeiol (Paris) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
ATRIAL FIBRILLATION IN A PEDIATRIC PATIENT WITH COVID-19 INFECTION |
Santi, AD, Aquino, et al |
Cardiol Young |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 interferes in the disclosure of the first Brazilian GIAHS site |
Santos, JB, Soares, et al |
Braz J Biol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sasitharan, A |
Clin Med (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Savaie, M |
Can J Anaesth |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Seasonal flu and COVID-19 recommendations for children, adolescents and young adults with
diabetes |
Scaramuzza, AE, Rabbone, et al |
Diabet Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Scarlat, MM, Sun, et al |
Int Orthop |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Schiermeier, Q, Else, et al |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Is It Lawful and Ethical to Prioritize Racial Minorities for COVID-19 Vaccines? |
Schmidt, H, Gostin, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Scott, JK, Breden, et al |
Curr Opin Syst Biol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sen-Crowe, B, McKenney, et al |
Ann Med Surg (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sensible Medicine-Balancing Intervention and Inaction During the COVID-19 Pandemic |
Seymour, CW, McCreary, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Navigating COVID-19 Testing, Special Considerations for the Cardiovascular
Clinician |
Shah, P, deFilippi, et al |
Circulation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
An Algorithm for Ramp Up of Ophthalmic Elective Surgeries Post-COVID-19 |
Shah, YS, Zafar, et al |
Ophthalmic Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Shaman, J, Galanti, et al |
Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shao, SC, Lai, et al |
J Patient Saf |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shapiro, J, McDonald, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shek, DTL |
J Adolesc Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shepherd, A |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Beyond business as usual: Radiology residency educational response to the COVID-2019
pandemic |
Shi, J, Miskin, et al |
Clin Imaging |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Shinohara, T, Saida, et al |
BMJ Open |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shum, CK, Shea, et al |
Psychogeriatrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Commentary on "Keeping Your Diagnostic Mind Open During the COVID-19 Pandemic" |
Siberry, GK |
Pediatr Infect Dis J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Siddiqi, HK, Libby, et al |
Trends Cardiovasc Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Siffels, LE |
Ethics Inf Technol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Silva Júnior, JVJ, Lopes, et al |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Singer, M |
Med Anthropol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19 Prevention and Protecting Sex Workers: A Call to Action |
Singer, R, Crooks, et al |
Arch Sex Behav |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 vaccine trials: Duty of care and standard of prevention considerations |
Singh, JA |
Vaccine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Singh, N, Ponde, et al |
Minerva Anestesiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Registry reports in COVID-19 patients: juggling with big data, poor data, and no
data |
Søfteland, J, Karason, et al |
Kidney Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7550164; COVID-19 Front Line - Why Focused Lung and Cardiovascular Ultrasound? |
Soliman-Aboumarie, H, Miglioranza, et al |
JACC Case Rep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Spaccarotella, CAM, De Rosa, et al |
Eur Heart J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Spelsberg, A, Keil, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7550090; Time to Treat: Applying Lessons Learned from Other Viral Syndromes
to SARS-CoV-2 |
Stevens, RW, Rivera, et al |
Mayo Clin Proc Innov Qual Outcomes |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Learning from the past: development of safe and effective COVID-19 vaccines |
Su, S, Du, et al |
Nat Rev Microbiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7544597; A race for a better understanding of COVID-19 vaccine non-adopters |
Su, Z, Wen, et al |
Brain Behav Immun Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sukumar, V, Pandey, et al |
Indian J Surg Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Efforts to cope with CBME in COVID-19 era to teach biochemistry in medical college |
Suneja, S, Gangopadhyay, et al |
Biochem Mol Biol Educ |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Non-invasive ventilatory support in COVID-19: operating in the evidence free
zone |
Szakmany, T |
Minerva Anestesiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Scientific Ambiguity in the Time of Coronavirus Disease 2019-Reply |
Tagarro, A, Moraleda, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tammaro, A, Adebanjo, et al |
Dermatol Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cutaneous Endothelial Dysfunction and Complement Deposition in COVID-19 |
Tammaro, A, Adebanjo, et al |
Am J Dermatopathol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tang, Y, Kwiatkowski, et al |
Eur Respir J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Tao, Z, Zhang, et al |
J Funct Foods |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7546996; The plight of COVID-19 pandemic on medical students and residency applicants |
Tariq, EF, Sah, et al |
Ann Med Surg (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tatu, AL, Nadasdy, et al |
Dermatol Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Recovery of individual Service personnel in the COVID-19 recovery phase |
Taylor, H, Quantick, et al |
BMJ Mil Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
THE QUEST FOR TIMELY INSIGHTS INTO COVID-19 SHOULD NOT COME AT THE COST OF SCIENTIFIC
RIGOR |
Tennant, P, Murray, et al |
Epidemiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Lancet Digital, Health |
The Lancet Digital Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Respiratory Drive Measurements do not Signify Conjectural P-SILI |
Tobin, MJ, Jubran, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Todorov, G, Uversky, et al |
Biomolecules |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Toros, K, Falch-Eriksen, et al |
Child Youth Serv Rev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Antivirals in the time of Covid-19 - not as easy as it looks! |
Trémolières, F |
Med Mal Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tsantes, AE, Tsantes, et al |
Diagnostics (Basel) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The coronavirus pandemic should strengthen governments' will to invest in adolescent
health |
Tsouros, A |
Int J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Under the Right Conditions, Center-Based Child Care is an Unlikely COVID-19 Threat
to Staff |
Tubbs-Cooley, H, Oster, et al |
Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Air disinfection procedures in the dental office during the COVID-19 pandemic |
Tysiąc-Miśta, M, Dubiel, et al |
Med Pr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Valença, AM, Telles, et al |
Braz J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Incidental finding of COVID-19 infection amongst staff at a primary care facility
in Ghana |
Vandyck-Sey, P, Amoh, et al |
Afr J Prim Health Care Fam Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Characterising neuropsychiatric disorders in patients with COVID-19 - Authors'
reply |
Varatharaj, A, Pollak, et al |
Lancet Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Vergallo, C |
Electromagn Biol Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7553995; Caring for Dialysis Patients in a Time of COVID-19 |
Verma, A, Patel, et al |
Kidney Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
von Oertzen, TJ, Macerollo, et al |
Eur J Neurol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
How pediatric resident's life has changed during the COVID-19 pandemic |
Votto, M, De Filippo, et al |
Ital J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Care during covid-19: partner attendance at maternity services |
Walsh, S, Simmons-Jones, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wan, LC, Chan, et al |
Ann Tour Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A Crowned Killer's Résumé: Genome, Structure, Receptors, and Origin of SARS-CoV-2 |
Wang, S, Trilling, et al |
Virol Sin |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Trustworthiness before Trust - Covid-19 Vaccine Trials and the Black Community |
Warren, RC, Forrow, et al |
N Engl J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Westreich, D, van Smeden, et al |
Epidemiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Wharton, C, Kotera, et al |
Nurs Crit Care |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
White, EM, Santostefano, et al |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Candidaemia in COVID-19, a link to disease pathology or increased clinical pressures? |
White, PL, Dhillon, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wijeratne, T, Crewther, et al |
J Neurol Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Opportunities and challenges for international societies in the COVID-19 era |
Wilkins-Haug, L, Veltman, et al |
Prenat Diagn |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wilmot, EG, Lumb, et al |
Diabet Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Wise, J |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Effectiveness of an ophthalmic hospital-based virtual service during COVID-19 |
Wu, X, Chen, et al |
Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Care workers' perspectives of factors affecting a sustainable aged care workforce |
Xiao, LD, Harrington, et al |
Int Nurs Rev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Yang, Chen, Zhou, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yastrebov, K, Brunel, et al |
Sci Rep |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7553862; The COVID-19 Cohort Ward Experience: All Hands on Deck |
Yen Tan, S, Mei Fong Chien, et al |
Clin Infect Pract |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7550261; Know thyself: Leading through the core of you in times of turbulence |
Yeo, RK |
Organ Dyn |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Yoshioka, T, Funada, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7552999; Prevention and control of COVID-19 in pastoral community through
One Health Approach |
Yousuf, A, Arifin, et al |
One Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Effect of radiotherapy interruption due to COVID-19 outbreak |
Yu, D, Hu, et al |
Radiother Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zahra, A, Sisu, et al |
J Clin Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Important Concerns Over SARS-CoV-2 Infection in Children With Cancer |
Zhang, L, He, et al |
JAMA Oncol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zhang, S, Wu, et al |
J Gastroenterol Hepatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zhang, XB, Hu, et al |
World J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zhao, JY, Zhang, et al |
Chin Med J (Engl) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
THE RISK OF CONTRACTING COVID-19 IS NOT INCREASED IN PATIENTS WITH CELIAC DISEASE |
Zhen, J, Stefanolo, et al |
Clin Gastroenterol Hepatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
ACE2 expression on the keratinocytes and SARS-CoV-2 percutaneous transmission, are
they related? |
Zhu, R, Shi, et al |
J Invest Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Oncol Nurs Forum |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID research updates: Are rapid coronavirus tests effective? It depends |
|
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7546317; Understanding COVID-19's Impact on College Students |
|
Teach Learn Nurs |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nat Cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
PLoS One |
Commentary/Editorial| Commentaire/Éditorial |
|
Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives