Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-10-20
Good afternoon,
There are 670 citations in today’s scan. 311 were considered primary research or review literature.
Highlights today include:
PUBLIC HEALTH INTERVENTION
·
Zhao et al. use an SEIR model to assess the impact of
infection prevention and control (IPC) policies on work resumption in Shanghai. The 14-day quarantine policy alone appears to be more effective in reducing transmission risk than the staged work resumption policy alone. The combined
staged and quarantined IPC policy led to the fewest confirmed cases caused by work resumption in Shanghai, and the spread of COVID-19 stopped at the earliest date.
IPAC
·
Ayyildiz, et al.
aim to determine whether a ventilator can be modified to provide ventilation of two or more patients simultaneously by using 3D designed and manufactured splitters. Two intensive care specialists voluntarily tried this study on themselves. It was concluded
from the study that 3D designed and manufactured two-port splitter can be used to separate the airway of a single ventilator to multiple patients within a very limited indication and time interval.
·
Hossain, et al.
summarize results on the development of a simple laboratory setup allowing measurement of charge and filtration efficiency in N95 masks. In particular, they propose and show that it is possible to recharge the masks post-decontamination and recover filtration
efficiency.
EPIDEMIOLOGY
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Murillo-Zamoea et al., evaluate factors predicting severe symptomatic laboratory-confirmed SARS-COV-2 reinfection. Patients with more serious primary
disease were more likely to develop severe symptoms during reinfection. In multiple analysis, factors associated with an increased risk of severe symptomatic SARS-COV-2 reinfection were increasing age, comorbidities (namely obesity, asthma, type 2 diabetes
mellitus) and previous severe laboratory-confirmed COVID-19.
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Singh et al.,
used Google's programming platform to aggregate relevant articles reporting the number of confirmed cases and deaths among health-care workers. Reports covering 67 countries showed that 99,847 health-care workers (HCWs) have been
reported to be infected with SARS-CoV-2 virus, with a majority reported in Europe. This included confirmed reports of 1732 doctors and
348 nurses. Five hundred and thirty-eight deaths were reported in 32 countries, amounting to a mortality among HCWs globally of 4%.
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Rizo-Téllez et al.
examined the efficacy of the lymphocyte-to-neutrophil ratio (LNR) and neutrophil-to-monocyte ratio (NMR) as predictors of in-hospital death at admission in patients with severe COVID-19. As compared to survivors, LNR was significantly decreased while
NMR was increased. LNR ≤ 0.088 predicted in-hospital mortality with a sensitivity of 85.00% and a specificity of 74.19%. NMR ≥ 17.75 was a better independent risk factor for mortality with a sensitivity of 89.47% and a specificity of 80%.
·
Villalobos reports that, on average, detecting 5 instead of 35 percent of the COVID-19 infections is associated
with multiplying the number of deaths by a factor of about 6. Based on this result, if the US would have tested with the same intensity as South Korea, about 85,000 out of their 126,000 reported deaths could have been avoided.
SURVEILLANCE
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Abu-Ali et al
quantified SARS-CoV-RNA in the raw sewage and along the main stages of the wastewater process from two different plants in Israel during this COVID-19 outbreak. Found that ca. 2 Log removal could be attained after primary and secondary treatment. Despite
this removal, significant concentrations of SARS-CoV-RNA (>100 copies per mL) could still be detected in the treated wastewater. However, after treatment by chlorination, SARS-CoV-RNA was detected only once, Results highlight the need to protect wastewater
treatment plants operators, as well as populations living near areas of wastewater discharge, from the risk of infection.
IMMUNOLOGY
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Guan et al.
investigate the dynamic changes of immune status in COVID-19 patients with clinical evolution. The immune status of COVID-19 patients is different in each stage, and dynamic monitoring of related indicators can help predict the disease and may avoid
cytokine storms.
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Debisarun et al
used an established in-vitro model of trained immunity, and demonstrated that the quadrivalent inactivated influenza vaccine used in the Netherlands in the 2019-2020 influenza season can induce a trained immunity response, including an improvement of
cytokine responses after stimulation of human immune cells with SARS-CoV-2. In addition, the authors found that SARS-CoV-2 infection was less common among Dutch hospital employees who had received influenza vaccination during the 2019/2020 winter season.
VACCINE RESEARCH
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McAuley et al.
neutralisation assays were performed using sera from ferrets which received two doses of the INO-4800 COVID-19 vaccine, and Australian virus isolates (VIC01, SA01 and VIC31) which either possess or lack this mutation but
are otherwise comparable. Through this approach, supported by biomolecular modelling of this mutation and the commonly-associated P314L mutation in the RNA-dependent RNA polymerase, we have shown that there is no experimental evidence to support this speculation.
We additionally demonstrate that the putative elastase cleavage site introduced by the D614G mutation is unlikely to be accessible to proteases.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura
Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Alex Gilbert, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Tracking SARS-CoV-2 RNA through the wastewater treatment process |
Abu-Ali, Hala, Yaniv, et al |
medRxiv |
Epidemiology| Épidémiologie Surveillance |
This study quantified SARS-CoV-RNA in the raw sewage and along the main stages of the wastewater process from two different
plants in Israel during this COVID-19 outbreak. And found that ca. 2 Log removal could be attained after primary and secondary treatment. Despite this removal, significant concentrations of SARS-CoV-RNA (>100 copies per mL) could still be detected in the treated
wastewater. However, after treatment by chlorination, SARS-CoV-RNA was detected only once, likely due to insufficient chlorine dose. The results highlight the need to protect wastewater treatment plants operators, as well as populations living near areas of
wastewater discharge, from the risk of infection. |
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Adapa, Venkata Suresh Babu, Adapa, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie |
This study estimated the Case Fatality Rate (CFR) in India, Indian States, and Union Territories during the pandemic in different phases. In the pre-lockdown
phase, the CFR whole India was 20.37%, North India ranging from Nil-100.00%, Western India ranging from Nil-100.00%, South India ranging from Nil-50.00%, East India ranging from Nil-100.00%, Northeast- Nil, and Central India ranging from Nil-100.00%.In lockdown
phase the CFR whole India was ranging from 4.15- 20.37%, North India- 0.00-53.70%, Western India- Nil-40.42%, South India - 0.00-42.3%, East India- 0.00-100%, Northeast- Nil -100.00%, and Central India- 0.00-45.30%.In post-lockdown phase the CFR whole India
was ranging from 2.50- 4.01%, North India- 0.45-4.82%, Western India- 0.71-7.24%, South India- 0.46-4.72%, East India- 0.00-0.89%, Northeast- Nil -100.00%, and Central India- 0.49-3.78%. |
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Coding-complete genome sequences of three sars-cov-2 strains from bangladesh |
Akter, S, Banu, et al |
Microbiology Resource Announcements |
Coronavirology| Coronavirologie |
We report the sequencing of three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomes from Bangladesh. We have identified a unique mutation
(NSP2_V480I) in one of the sequenced genomes compared to the sequences available in the Global Initiative on Sharing All Influenza Data (GISAID) database. |
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Risk factors for hospital admission among COVID-19 patients with diabetes A study
from Saudi Arabia |
Al Hayek, AA, Robert, et al |
Saudi medical journal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objectives: To elucidate the risk factors for hospital admission among COVID-19 patients with type 2 diabetes mellitus (T2DM). 806 patients with T2DM were
included in this analysis. Among COVID-19 patients with diabetes, higher age, high HbA1c level, and presence of other comorbidities were found to be significant risk factors for the hospital admission. |
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Alfaro, M, Alfaro, et al |
Chemical Physics Letters |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This paper presents identification of potential inhibitors of SARS-CoV-2 papain-like protease from tropane alkaloids from Schizanthus porrigens, using
molecular docking method. Binding affinities were compared with those obtained with Lopinavir as a SARS-CoV-2 papain-like protease inhibitor. Overall, our findings indicate that Schizanthine Z binds to the SARS-CoV-2 papain-like protease with relatively high
affinity and favorable ADME properties. Therefore, Schizanthine Z may represent an appropriate compound for further evaluation in antiviral assays. © 2020 Elsevier B.V. |
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Ali, Muhammad, Mehmood, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
This paper presents the protocol of the randomized controlled clinical trial being carried out to examine the efficacy
of intravenous infusions of umbilical cord (UC)-derived mesenchymal stem cell (MSC) for the treatment of COVID-19 when administered to patients with moderate to severe symptoms. In addition, the trial will determine whether : (i) UC-derived MSCs are effective
in reducing 30-day all-cause mortality (primary endpoint) and (ii) UC-derived MSCs are effective in preventing progression to mechanical ventilation, and/or reducing an inflammatory response, and/or improving overall patient condition (secondary endpoints). |
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The nCOVID-19 and financial stress in the USA: health is wealth |
Alola, AA, Alola, et al |
Environment, Development and Sustainability |
Economics | Économie |
Since its first report in the USA on 13 January 2020, the novel coronavirus (nCOVID-19) pandemic like in other previous
epicentres in India, Brazil, China, Italy, Spain, UK, and France has until now hampered economic activities and financial markets. To offer one of the first empirical insights into the economic/financial effect of the COVID-19 pandemic, especially in the USA,
this study utilized the daily frequency data for the period 25 February 2020–30 March 2020. By employing the empirical Markov switching regression approach and the compliments of cointegration techniques, the study establishes a two-state (stable and distressing)
financial stress situation resulting from the effects of COVID-19 daily deaths, COVID-19 daily recovery, and the USA’ economic policy uncertainty. From the result, it is assertive that daily recovery from COVID-19 eases financial stress, while the reported
daily deaths from COVID-19 further hamper financial stress in the country. Moreover, the uncertainty of the USA’ economic policy has also cost the Americans more financial stress and other socio-economic challenges. While the cure for COVID-19 remains elusive,
as a policy instrument, the USA and similar countries with high severity of COVID-19 causalities may intensify and sustain the concerted efforts targeted at attaining a landmark recovery rate. © 2020, The Author(s). |
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Aroojis, A, Pragadeeswaran, et al |
Indian Journal of Orthopaedics |
Healthcare Response | Réponse des soins de santé |
As clubfoot clinics begin phased re-opening, we describe various innovative techniques to protect patients and healthcare
providers during delivery of clubfoot treatment services. In addition to standard social distancing measures and sanitization protocols, we report a simple and innovative technique of ‘barrier casting’ or ‘ring-fencing’ to potentially reduce the risk of droplet
infection and airborne transmission during clubfoot casting and tenotomy. We have utilized these innovative techniques in 43 consecutive patients since clinic re-opening and are satisfied that they are effective, economical and easily reproducible even in
countries with limited resources. |
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Voice Quality Evaluation in Patients With
COVID-19: An Acoustic Analysis |
Asiaee, M, Vahedian-azimi, et al |
Journal of Voice |
Clinical data| Données cliniques |
With the COVID-19 outbreak around the globe and its potential effect on infected patients’ voice, this study set out
to evaluate and compare the acoustic parameters of voice between healthy and infected people in an objective manner. Voice samples of 64 COVID-19 patients and 70 healthy Persian speakers who produced a sustained vowel /a/ were evaluated. The results revealed
significant differences in CPP, HNR, H1H2, F0SD, jitter, shimmer, and MPT values between COVID-19 patients and the healthy participants. The statistical analysis of the data revealed significant differences between the experimental and control groups in this
study. Changes in the acoustic parameters of voice are caused by the insufficient airflow, and increased aperiodicity, irregularity, signal perturbation and level of noise, which are the consequences of pulmonary and laryngological involvements in patients
with COVID-19. |
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The footprints of COVID-19 on Central Eastern
European stock markets: an intraday analysis |
Aslam, F, Nogueiro, et al |
Post-Communist Economies |
Economics | Économie |
This study analyses the intraday multifractal behaviour of three Central Eastern European stock markets by deploying
five-minute index data ranging from December 2019 to May 2020. With the analysis of multifractality, we can evaluate the degree of efficiency of the stock markets analysed. We divided the whole sample into three different periods of about two months each.
Data for the Czech Republic, Hungary and Poland are used and their behaviour is compared with Germany (as a benchmark of the European Union) and Italy and Spain (as the most affected countries by Covid-19 in Europe). For the analysis, we employ multifractal
detrended fluctuation analysis after using seasonal-trend decompositions using the loess method. The results confirm that the degree of multifractality varies in the different periods, with increasing multifractality in February–March and a recovery in April–May.
Furthermore, the behaviour of these stock markets shifted from persistent to anti-persistent. |
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Aydın, L, Ari, et al |
Energy Exploration and Exploitation |
Economics | Économie |
This study aims to analyze the compensating role of falling oil prices for impacts of Covid-19 on non-recoverable sectors
in Turkey, e.g. tourism, travel, and transportation. The main argument in the study, that is falling prices in oil can contribute to compensation for losing revenue from tourism, travel, and transport. |
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Aylie, NS, Mekonen, et al |
Psychology Research and Behavior Management |
Public Health response| Interventions de santé publique |
To assess the psychological impacts of COVID-19 pandemic among university students in Bench-Sheko Zone, South-west,
Ethiopia, 2020. A community-based cross-sectional study was conducted from May 15 to June 15/2020. A systematic sampling technique was employed to select the study participants. The data were entered into EpiData 3.1 and exported to SPSS version 24 for analysis.
Bivariate and multivariable logistic regression were used to identify candidates and independent factors respectively. Independent factors of depression, anxiety, and stress were assessed using AORs with 95% confidence level at P-value <0.05 cut point. Three
hundred and twenty-two university students were included with a 97.5% response rate. The prevalence of depression, anxiety, and stress was 21.2%, 27.7%, and 32.5%, respectively. Being female, staying at home, history of medical illness, and poor and moderate
social support increased the risk of depression. Not living with their parents, relatives got coronavirus and low family income were risk factors for anxiety. Moreover, substance use, depression, anxiety, and poor social support were increasing the risk of
stress among university students. |
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3D-Printed Splitter for Use of a Single Ventilator on Multiple Patients during COVID-19 |
Ayylldlz, S, Dursun, et al |
3D Printing and Additive Manufacturing |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
The aim of this study was to determine whether a ventilator can be modified to provide ventilation of two or more patients
simultaneously by using 3D designed and manufactured splitters. A two-port and four-port splitter were designed. Two intensive care specialists voluntarily tried this study on themselves. It was concluded from the study that 3D designed and manufactured two-port
splitter can be used to separate the airway of a single ventilator to multiple patients within a very limited indication and time interval. |
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COVID-19 in an Infant with Congenital Adrenal Hyperplasia: A Case
Report |
Azouz, H, Gerrits, et al |
Global Pediatric Health |
Clinical data| Données cliniques |
In the midst of current SARS-CoV-2 pandemic, little is known about the implications of this new virus on patients with
underlying chronic comorbidities. Herein, we present a case of a 5-week-old infant with congenital adrenal hyperplasia who acquired SARS-CoV-2 and recovered with minimal medical support. © The Author(s) 2020. |
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Backer, JantienA, Mollema, et al |
medRxiv |
Public Health response| Interventions de santé publique |
This study measured the actual reduction of contacts when physical distancing measures were implemented. The average
number of community contacts per day was reduced from on average 14.9 (interquartile range: 4-20) in the 2016/2017 survey to 3.5 (0-4) after physical distancing measures were implemented, and rebounded to 8.8 (1-10) after some of these measures were relaxed.
All age groups restricted their number of community contacts to at most 5 contacts on average after physical distancing measures were implemented. After relaxation, children reverted to baseline levels while elderly had a number of community contacts that
was less than half their baseline levels. |
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Baker, AN, Richards, et al |
ACS Central Science |
Coronavirology| Coronavirologie |
There is an urgent need to understand the behavior of the novel coronavirus (SARS-COV-2), which is the causative agent
of COVID-19, and to develop point-of-care diagnostics. Here, a glyconanoparticle platform is used to discover that N-acetyl neuraminic acid has affinity toward the SARS-COV-2 spike glycoprotein, demonstrating its glycan-binding function. Optimization of the
particle size and coating enabled detection of the spike glycoprotein in lateral flow and showed selectivity over the SARS-COV-1 spike protein. Using a virus-like particle and a pseudotyped lentivirus model, paper-based lateral flow detection was demonstrated
in under 30 min, showing the potential of this system as a low-cost detection platform. Copyright © 2020 American Chemical Society. |
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Banerjee, Arinjay, El-Sayes, et al |
bioRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
This study demonstrated that SARS-CoV-2 infection induces a mild type I IFN response in vitro and in moderate cases
of COVID-19. In vitro stimulation of type I IFN expression and signaling in human airway epithelial cells is associated with activation of canonical transcriptions factors, and SARS-CoV-2 is unable to inhibit exogenous induction of these responses. The data
demonstrate that SARS-CoV-2 is not adept in blocking type I IFN responses and provide support for ongoing IFN clinical trials. |
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Italian SARS-CoV-2 patients in intensive care: Towards an identikit for subjects
at risk? |
Baronio, M, Freni-Sterrantino, et al |
European review for medical and pharmacological sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to investigate patient characteristics and factors that increase the risk of being
admitted to intensive care and that influence survival in cases of SARS-CoV-2 pneumonia. 191 patients were recruited from Lombardy and logistic regression and survival analysis were carried out to investigate the risk of being admitted to intensive care and
the risk of death. Patients admitted to intensive care were more likely to be of intermediate age (60-69 years; OR 3.23, 95% CI 1.32-8.38), overweight (OR 2.66, 95% CI 1.02-7.07) or obese (OR 5.63, 95% CI 1.73-21.09) and with lymphocytopenia (OR 2.75, 95%
CI 1.17-6.89) than the 34 patients admitted to the ordinary ward. |
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SARS-CoV-2 infection in an advanced rheumatoid arthritis patient |
Bazmjoo, A, Bagherzadeh, et al |
APMIS |
Clinical data| Données cliniques |
Here, we present a complicated case of SARS‐CoV‐2 infection in a female rheumatoid arthritis patient. |
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Adherence to the Physical Distancing Measures during the COVID-19 Pandemic: A HAPA-Based
Perspective |
Beeckman, M, De Paepe, et al |
Applied Psychology: Health and Well-Being |
Public Health response| Interventions de santé publique |
The Health Action Process Approach (HAPA) describes personal determinants that play a key role in behavior change.
This Belgian study investigated whether these determinants are associated with adherence to physical distancing measures to prevent the spread of COVID-19 (i.e. keeping 1.5 m physical distance and staying at home). Decreased psychosocial well-being and lack
of social support were explored as barriers to adherence. Self-efficacy, outcome expectancies, intention, action planning, and coping planning were related to adhering to, difficulty with, and perseverance in, adhering to physical distancing measures. Decreased
psychosocial well-being and lack of social support were related to more difficulties with adhering to physical distancing and lower perseverance. |
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The first case of systemic lupus erythematosus (SLE) triggered by COVID-19 infection |
Bonometti, R, Sacchi, et al |
European review for medical and pharmacological sciences |
Clinical data| Données cliniques |
This case report describes a patient who following COVID-19 infection developed autoimmune antibodies which persisted
in time longer than viral phase. Those antibodies can be responsible for the multi pathological clinical picture showed from our patient that, according to EULAR 2019 criteria, could be classified as systemic lupus erythematosus (SLE). SLE is probably one
of the possible chronic rheumatologic diseases triggers by COVID-19 and this is the first case of SLE with vasculitis actually described in literature. |
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Bucak, T, Yiğit, et al |
International Journal of Hospitality Management |
Economics | Économie |
The aim of the present study is to reveal the opinions of the chefs who working as a manager in the kitchen department
within the food and beverage sector about what changes might have occurred in their occupation and food and beverage sector after the COVID-19 outbreak. The data were collected through online interview forms and content analysis was used as a data analysis
method. The findings reveal three main categories: general opinions after the COVID-19 outbreak, changes that could occur in the food and beverage sector after COVID-19 outbreak, and thoughts for the future of the chef occupation after the COVID-19 outbreak.
Since this paper is the first to reveal the opinions of the chefs about what changes might have occurred in their occupation and food and beverage sector after the COVID-19 outbreak, and no similar study could be found in the existing literature, these findings
are original. © 2020 Elsevier Ltd |
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Butgereit, L |
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Public health interventions*| Interventions de santé publique Public Health response|
Interventions de santé publique |
This paper looks at the situation in South Africa which implemented various levels of lockdown with each level having
its own rules and regulations. Lockdown Level 5 was the most severe lockdown in South Africa and, at the time of writing this paper, the country was under a less severe Lockdown Level 3. This lockdown affects more people than the COVID-19 disease itself. This
paper looks at how Geographical Information Systems can be combined with various domain specific data in order to assist in identifying entities which are adversely affected differently by the different lockdown levels. For example, at some lockdown levels,
schools were allowed to operate whereas at more strict lockdown levels, schools were not allowed to operate. In such cases, schools would need to know which pupils lived in which districts. At some lockdown levels, alcohol could be sold whereas at more strict
lockdown levels, alcohol could not be sold. In such cases, alcohol manufacturers such as breweries and distilleries would need to know how their outlets would be affected and adjust production accordingly. |
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Abnormal antibodies to self-carbohydrates in SARS-CoV-2
infected patients |
Butler, DorothyL, Gildersleeve, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
This study used a carbohydrate antigen microarray with over 800 individual components to profile serum anti-glycan
antibodies in COVID-19 patients and healthy control subjects. In COVID-19 patients, the authors observed abnormally high IgG and IgM antibodies to numerous self-glycans, including gangliosides, N-linked glycans, LacNAc-containing glycans, blood group H, and
sialyl Lewis X. The detection of antibodies to self-glycans has important implications for using convalescent serum to treat patients, developing safe and effective SARS-CoV-2 vaccines, and understanding the risks of infection. In addition, this study provides
new insight into the immune responses to SARS-CoV-2 and illustrates the importance of including host and viral carbohydrate antigens when studying immune responses to viruses. |
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Cross-country differences in anxiety and behavioral response to the Covid-19
pandemic |
Buyukkececi, Z |
European Societies |
Public Health response| Interventions de santé publique |
Focusing on 54 countries, this study investigates the country-level determinants of anxiety and behavioral response
to the Covid-19 pandemic using economic preferences and development and tests to what extent these indicators account for cross-country differences. Results show that anxiety was less common among more patient and developed societies. Yet, altruistic societies
suffered more from anxiety. Higher levels of positive reciprocity and trust were also associated with stronger health-protective behavioral responses. |
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Cai, W, Liu, et al |
Academic Radiology |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study was to investigate the CT quantification of COVID-19 pneumonia and its impacts on the assessment of disease
severity and the prediction of clinical outcomes in the management of COVID-19 patients. Ninety-nine COVID-19 patients who were confirmed by positive nucleic acid test (NAT) of RT-PCR and hospitalized from January 19, 2020 to February 19, 2020 were collected
for this retrospective study. Patients were classified into three groups of disease severity: moderate (n = 25), severe (n = 47) and critical (n = 27), according to the clinical staging. The % nonlesion lung volume (%NLLV) in three severity groups were 92.18
± 9.89%, 82.94 ± 16.49%, and 66.19 ± 24.15% with p value <0.05 among each two groups. CT quantification and machine-learning models show great potentials for assisting decision-making in the management of COVID-19 patients by assessing disease severity and
predicting clinical outcomes. |
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Physical Distancing and Future COVID-19 Deaths
in Brazil: Evidence of a Paradoxical Effect |
Campello de Souza, Bruno and Campello de Souza, Fernando Menezes, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study investigated the relationship between physical distancing and the number of future COVID-19 deaths in Brazil.
The degree of physical distancing at a given date showed a strong positive Spearman correlation to the number of COVID-19 deaths 40 days later (Rho=.75, p<.01, for the Social Isolation Index, and Rho=.83, p<.01, for the added number of hours spent in one’s
residence). The trajectory of deaths as a function of time and physical distancing indicated that more distancing was associated to a higher peak number of deaths, a sooner arrival of that peak, and more accumulated deaths. A Social Isolation Index above 45%
and/or spending more than 15% more hours at one’s residence, as well as a rapid and intense elevation in either variable, were linked to 13.8% more future COVID-19 deaths. |
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Wearing Face Masks Strongly Confuses Counterparts in Reading Emotions |
Carbon, CC |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
In the present experiment, we tested the impact of face masks on the readability of emotions. Lower accuracy and lower
confidence in one’s own assessment of the displayed emotions indicate that emotional reading was strongly irritated by the presence of a mask. We further detected specific confusion patterns, mostly pronounced in the case of misinterpreting disgusted faces
as being angry plus assessing many other emotions (e.g., happy, sad, and angry) as neutral. |
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Caruso, I, Di Molfetta, et al |
Diabetes/metabolism research and reviews |
Public Health response| Interventions de santé publique |
Assessed changes in glucose metrics and their association with psychological distress and lifestyle changes in patients
with type 1 diabetes (T1D) using flash glucose monitoring (FGM) during lockdown. Out of 84 patients assessed for eligibility, 48 had sufficient FGM data to be included in the analysis. FGM data analysis revealed significant reductions in coefficient of variation,
number of hypoglycaemic events, and time below range, while no changes were found in time in range, time above range, mean sensor glucose, and glucose management indicator. Moreover, the frequency of sweets consumption was inversely related to the occurrence
of hypoglycaemic events during lockdown. |
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Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein |
Casalino, L, Gaieb, et al |
ACS Central Science |
Coronavirology| Coronavirologie |
We reveal an essential structural role of N-glycans at sites N165 and N234 in modulating the conformational dynamics
of the spike's receptor binding domain (RBD), which is responsible for ACE2 recognition. This finding is corroborated by biolayer interferometry experiments, which show that deletion of these glycans through N165A and N234A mutations significantly reduces
binding to ACE2 as a result of the RBD conformational shift toward the "down"state. Additionally, end-to-end accessibility analyses outline a complete overview of the vulnerabilities of the glycan shield of the SARS-CoV-2 S protein, which may be exploited
in the therapeutic efforts targeting this molecular machine. Overall, this work presents hitherto unseen functional and structural insights into the SARS-CoV-2 S protein and its glycan coat, providing a strategy to control the conformational plasticity of
the RBD that could be harnessed for vaccine development. |
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Catelli, R, Gargiulo, et al |
Applied Soft Computing Journal |
Clinical data| Données cliniques |
A new Italian de-identification data set has been created from the COVID-19 clinical records made available by the
Italian Society of Radiology (SIRM). The objective is to investigate their ability to transfer knowledge between different languages while maintaining the necessary features to correctly perform the Named Entity Recognition task for de-identification. |
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Charlotte, P, Gaël, et al |
Swiss Medical Weekly |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We describe the clinical characteristics, outcomes 30 days after onset of symptoms and in-hospital mortality of a cohort
of patients hospitalised for COVID-19 in a Swiss area. One hundred ninety-six patients were included in the study. In our population, 119 (61%) were male and the median age was 70 years. Forty-nine patients (25%) were admitted to the intensive care unit (ICU).
Thirty days after onset of the symptoms, 60% had returned home. Among them, 63% still presented symptoms. |
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Ischemic Brachial Plexopathy in an Adult Patient
with Severe COVID-19: A Case Report |
Chaudhary, Ashok, Kamar, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques |
This report presents a case of an adult with severe COVID-19 whose clinical course was complicated by a sudden onset
weakness and loss of sensation in his right upper extremity, with concomitant new onset blackish discoloration of one of his fingernails. This was accompanied by a significant decrease in platelet count when compared to his baseline. Based on clinical grounds,
the diagnosis of ischemic brachial plexopathy was made after which the patient was started on low molecular weight heparin. |
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A Retrospective Analysis of the Coagulation Dysfunction in COVID-19 Patients |
Chen, X, Wang, et al |
Clinical and Applied Thrombosis/Hemostasis |
Clinical data| Données cliniques |
To discuss the coagulation dysfunction in COVID-19 patients and to find new biomarkers to separate severe COVID-19
patients from mild ones. We use a retrospective analysis of 88 COVID-19 patients, and compare the coagulation function between severe and mild groups. We found the prothrombin time (PT), thrombin time (TT), D-dimer were significantly higher in the severe group
(P < 0.05), and the highest area under the curve (AUC) is 0.91 for D-dimer, while the AUC of PT and TT were 0.80 and 0.61 respectively. We identified that D-dimer has a better value in predicting patients who are likely to develop into severe cases, with the
sensitivity and specificity were 84.4% and 88.8%, respectively. D-dimer may be a good biomarker to separate the severe COVID-19 patients from the mild ones. |
|
Choi, Yeol Kyo, Cao, et al |
bioRxiv |
Coronavirology| Coronavirologie |
In this work, multiple μs-long all-atom molecular dynamics simulations were performed to provide deeper insight into
the structure and dynamics of S protein, and glycan functions. The simulations reveal that the highly flexible stalk is composed of two independent joints and most probable S protein orientations are competent for ACE2 binding. And identified multiple glycans
stabilizing the open and/or closed states of receptor binding domain (RBD), and demonstrated that the exposure of antibody epitopes can be captured by detailed antibody-glycan clash analysis instead of a commonly-used accessible surface area analysis that
tends to overestimate the impact of glycan shielding and neglect possible detailed interactions between glycan and antibody. |
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Chowdhury, R, Sneddon, et al |
Mathematical Biosciences and Engineering |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, we analyzed the correlated count outcomes, daily new cases, and fatalities, and assessed the impact
of some covariates by adopting a generalized bivariate Poisson model. There are different effects of duration on new cases and deaths in different countries. Also, the regional variation found to be different, and population density has a significant impact
on outcomes. |
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|
Chuh, A |
International journal of dermatology |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
In this study, we aim to investigate this association in civilians wearing gear during volunteered sanitation works
during the early phase of the COVID‐19 pandemic in Hong Kong. The incidence was significantly higher than in the control periods (IR: 3.57, 95% CI: 1.79–7.43). Male predominance was significant (P < 0.001). Study subjects were 21.2 (95% CI: 11.0–31.4) years
younger than patients in the control periods. For the study subjects, the distribution of erythematous or skin‐colored folliculocentric dome‐shaped papules and pustules were all compatible with body parts covered by the gear. Lesional biopsy performed on two
patients revealed eosinophilic dermal infiltrates within and around the pilosebaceous units. Polarized dermoscopy revealed folliculitis with peri‐/interfollicular vascular proliferation. Lesion onsets were 6.4 (SD: 2.1) days after wearing gear. Remissions
were 16.7 (SD: 7.5) days after ceasing to wear gear and treatments. Wearing protective gear in volunteered sanitizing works could be associated with eosinophilic folliculitis. Owing to the significant temporal and distributional correlations, the association
might be causal. |
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Collins, OC, Duffy, et al |
PeerJ |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
In recent history, COVID-19 is one of the worst infectious disease outbreaks currently affecting humanity globally.
Using real data on the COVID-19 outbreak from 22 January 2020 to 30 March 2020, we developed a mathematical model to investigate the impact of control measures in reducing the spread of the disease. Analyses of the model were carried out to determine the dynamics.
The results of the analyses reveal that, using the data from China, implementing all possible control measures best reduced the rate of secondary infections. However, quarantine (isolation) of infectious individuals is shown to have the most dominant effect.
This possibility emphasizes the need for extensive testing due to the possible prevalence of asymptomatic COVID-19 cases. Copyright 2020 Collins and Duffy. |
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The impact of school reopening strategies during COVID-19: A case study of Sao Paulo, Brazil |
Cruz, EduardoHM, Maciel, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Using computer simulation, this study analyzed different strategies to reopen schools in the Sao Paulo Metropolitan
Area, including the official reopening plan. The results indicate that reopening schools with all students at once has a big impact on the number of new COVID-19 cases, which could cause a collapse of the health system. On the other hand, a controlled school
reopening avoids the collapse of the health system, with a maximum ICU occupancy between 48.8% and 97.8%, depending on how people attending school follow sanitary measures. Postponing the schools' return date for after a vaccine becomes available can save
up to 37,753 lives just in the Sao Paulo Metropolitan Area. |
|
da Silva, FMA, da Silva, et al |
Memorias do Instituto Oswaldo Cruz |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
To investigate, in silico, two of the most abundant f lavonoid glycosides from Dysphania ambrosioides; a medicinal
plant found in many regions of the world, along with some of the putative derivatives of these f lavonoid glycosides in the human organism as potential inhibitors of the SARS-CoV-2 3CLpro and RdRp. Using a molecular docking approach, the interactions and the
binding affinity with SARS-CoV-2 3CLpro and RdRp were predicted for quercetin-3-O-rutinoside (rutin), kaempferol-3-O-rutinoside (nicotif lorin) and some of their glucuronide and sulfate derivatives. Docking analysis, based on the crystal structure of 3CLpro
and RdRp, indicated rutin, nicotif lorin, and their glucuronide and sulfate derivatives as potential inhibitors for both proteins. Also, the importance of the hydrogen bond and π-based interactions was evidenced for the presumed active sites. these results
suggest that both f lavonoid glycosides and their putative human metabolites can play a key role as inhibitors of the SARS-CoV-2 3CLpro and RdRp. Obviously, further researches, mainly in vitro and in vivo experiments, are necessary to certify the docking results
reported here, as well as the adequate application of these substances. Furthermore, it is necessary to investigate the risks of D. ambrosioides as a phytomedicine for use against COVID-19. |
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Dai, W, Chen, et al |
Canadian Respiratory Journal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Epidemiological investigations were conducted in the Zhejiang province to understand the epidemiology and clinical
characteristics of asymptomatic patients with COVID-19. The median age was 28 years in asymptomatic patients and 48 years in symptomatic patients. The proportion who were female was 77.3% in asymptomatic patients and 36.3% in symptomatic patients. The proportion
of patients with coexisting diseases was 4.5% in asymptomatic patients and 38.0% in symptomatic patients. The proportion of patients with increased CRP was 13.6% in the asymptomatic group and 61.1% in the symptomatic group. The proportion of patients received
antiviral therapy was 45.5% in the asymptomatic group and 97.9% in the symptomatic group. The proportion of patients received oxygen therapy was 22.7% in the asymptomatic group and 99.1% in symptomatic patients. By March 16, 2020, all patients were discharged
from the hospital, and no symptoms had appeared in the asymptomatic patients during hospitalization. The median course of infection to discharge was 21.5 days in asymptomatic patients and 22 days in symptomatic patients. |
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The recovery of global stock markets indices after impacts due to pandemics |
David, SA, Inácio, et al |
Research in International Business and Finance |
Economics | Économie |
Authors discuss the impact of COVID-19 outbreaks in economies and financial markets. The results show that the shocks
caused by the diseases significantly affected the markets. |
|
De Backer, Charlotte Jacqueline, Teunissen, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
This cross sectional online survey evaluated the changes regarding planning, selecting, and preparing healthier foods
in 38 countries worldwide. Small increases ( p< 0·0001) in planning (4·7 SD 1·3, 4.9 SD 1·3), selecting (3·6 SD 1·7, 3·7 SD 1·7), and preparing (4·6 SD 1·2, 4·7 SD 1·3) healthier foods were found for women and men. Perceived time availability and working from
home were associated with positive changes ( p< 0·0001). Psychological distress acted as a barrier for women, and an enabler for men ( p< 0·0001). Financial distress acted as a barrier and enabler for men and women, depending on other sociodemographic variables
( p< 0·0001). |
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De, C, Wignall, et al |
Indian Journal of Orthopaedics |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This UK based multi-centre study reports clinical characteristics, early outcomes and predictors of mortality in 34
consecutive COVID-19-positive hip fractures so that the lessons learnt could be utilised in other parts of World who are at a different phase of the pandemic. Overall, 12% of hip fractures were COVID positive with the mortality rate of 41.2%. The higher age
(p = 0.036) and male gender (p = 0.025) was significantly associated with mortality and most of the deaths were between American Society of Anaesthesiologists (ASA) grade 3 and 4 patients. The patients having intramedullary (IM) nailing were more likely to
die (p = 0.02). There was no difference in laboratory parameters but there was significant difference in findings on chest radiographs (p < 0.001), post-operative oxygen requirements (p = 0.006) and early respiratory complications (p = 0.006). |
|
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The effect of influenza vaccination on trained immunity:
impact on COVID-19 |
Debisarun, PriyaA, Struycken, et al |
medRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
Using an established in-vitro model of trained immunity, this study demonstrated that the quadrivalent inactivated
influenza vaccine used in the Netherlands in the 2019-2020 influenza season can induce a trained immunity response, including an improvement of cytokine responses after stimulation of human immune cells with SARS-CoV-2. In addition, the authors found that
SARS-CoV-2 infection was less common among Dutch hospital employees who had received influenza vaccination during the 2019/2020 winter season (RR = 0,61 (95% CI, 0.4585 - 0.8195, P = 0.001). In conclusion, a quadrivalent inactivated influenza vaccine can induce
trained immunity responses against SARS-CoV-2, which may result in relative protection against COVID-19. |
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Targeting androgen regulation of TMPRSS2 and ACE2 as
a therapeutic strategy to combat COVID-19 |
Deng, Qu, Rasool, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study presents evidence for the transcriptional regulation of SARS-CoV-2 host cell receptor ACE2 and co-receptor
TMPRSS2 by androgen in mouse tissues and human prostate and lung cell lines. Additionally, demonstrate the endogenous interaction between TMPRSS2 and ACE2 in human cells and validate ACE2 as a TMPRSS2 substrate. In an overexpression model, and the prostate
and lung cells, Camostat – a TMPRSS2 inhibitor, blocked the cleavage of pseudotype SARS-CoV-2 surface Spike without disrupting TMPRSS2-ACE2 interaction. Thus providing evidence for the first time a direct role of TMPRSS2 in priming the SARS-CoV-2 Spike protein,
required for viral fusion to the host cell. Importantly, androgen-deprivation, anti-androgens such as enzalutamide/AR-PROTAC, or Camostat treatment attenuated the SARS-CoV-2 S-mediated entry in lung and prostate cells. |
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Multi-organ impairment in low-risk individuals with
long COVID |
Dennis, Andrea, Wamil, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study assessed the impact of long COVID (persistent symptoms three months post-infection) across multiple organs
in low-risk individuals. Between April and September 2020, 201 individuals (mean age 44 (SD 11.0) years, 70% female, 87% white, 31% healthcare workers) completed assessments following SARS-CoV-2 infection (median 140, IQR 105-160 days after initial symptoms).
The prevalence of pre-existing conditions (obesity: 20%, hypertension: 6%; diabetes: 2%; heart disease: 4%) was low, and only 18% of individuals had been hospitalised with COVID-19. Fatigue (98%), muscle aches (88%), breathlessness (87%), and headaches (83%)
were the most frequently reported symptoms. Ongoing cardiorespiratory (92%) and gastrointestinal (73%) symptoms were common, and 42% of individuals had ten or more symptoms. There was evidence of mild organ impairment in heart (32%), lungs (33%), kidneys (12%),
liver (10%), pancreas (17%), and spleen (6%). Single (66%) and multi-organ (25%) impairment was observed, and was significantly associated with risk of prior COVID-19 hospitalisation (p<0.05). |
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COVID-19 patients exhibit reduced procoagulant platelet responses |
Denorme, F, Manne, et al |
Journal of Thrombosis and Haemostasis |
Clinical data| Données cliniques Animal model | Modèle animal |
Examined if procoagulant platelet formation is altered in COVID-19 patients and if procoagulant platelets contribute
to pulmonary thrombosis. observed that platelets isolated from COVID-19 patients had a reduced ability to become procoagulant compared to those from matched healthy donors, as evidenced by reduced mitochondrial depolarization and phosphatidylserine exposure
following dual stimulation with thrombin and convulxin. To understand what impact reduced procoagulant platelet responses might have in vivo, we subjected mice with a platelet-specific deletion of cyclophilin D, which are deficient in procoagulant platelet
formation, to a model of pulmonary microvascular thrombosis. Mice with platelets lacking cyclophilin D died significantly faster from pulmonary microvascular thrombosis compared to littermate wild-type controls. These results suggest dysregulated procoagulant
platelet responses may contribute to thrombotic complications during SARS-CoV-2 infection. |
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Donsimoni, JR, Glawion, et al |
CESifo Economic Studies |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We quantify the effects of restrictions of social contacts (RSC) for Germany. We initially employ a purely statistical
approach to predicting prevalence of Covid-19 if RSC had been upheld after 20 April. We employ these findings and feed them into our theoretical model. |
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Doornik, JA, Castle, et al |
International Journal of Forecasting |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission |
We have been publishing real-time forecasts of confirmed cases and deaths from coronavirus disease 2019 (COVID-19)
since mid-March 2020 (published at www.doornik.com/COVID-19). These forecasts are short-term statistical extrapolations of past and current data. They assume that the underlying trend is informative regarding short-term developments but without requiring other
assumptions about how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is spreading, or whether preventative policies are effective. Thus, they are complementary to the forecasts obtained from epidemiological models. The forecasts are
based on extracting trends from windows of data using machine learning and then computing the forecasts by applying some constraints to the flexible extracted trend. These methods have been applied previously to various other time series data and they performed
well. They have also proved effective in the COVID-19 setting where they provided better forecasts than some epidemiological models in the earlier stages of the pandemic. © 2020 The Authors |
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|
Douville, Nicholas, Douville, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
The ability to predict which patients may require mechanical ventilation, prior to clinical decompensation, allows
increased acuity of care and targeted interventions to potentially mitigate deterioration. Ninety-three (23%) of the 398 COVID-19 positive patients required mechanical ventilation or died within 14-days of admission. The Random Forest model predicts pending
mechanical ventilation with good discrimination (c-statistic = 0.858, 95% confidence interval 0.841 to 0.874), which is comparable to the discrimination of the generalized estimating equation regression. Vitals sign data including SpO 2 /FiO 2 ratio (Z-score
= 8.56), respiratory rate (5.97), and heart rate (5.87) had the highest predictive utility in this algorithm. In the highest risk cohort, the number of patients needed to identify (NNI) a single new case of mechanical ventilation was 3.2 and for our second
risk quintile, NNI was 5.0. |
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Drewnick, F, Pikmann, et al |
Aerosol Science and Technology |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
As a consequence of the COVID-19 pandemic caused by the SARS-CoV-2 virus, the widespread daily use of face masks is
promoted worldwide. Particle-size dependent filtration efficiencies (FE; dp = 30 nm–10 µm), applying a particle counting approach, and additionally pressure drops (Δp) were determined for 44 samples of household materials and several medical masks. Huge FE
differences were found between sample materials and for different particle sizes, spanning from 2.5 µm. Measurements at different numbers of layers showed that stacks of textiles can be treated as separate filters and total FE and Δp can readily be estimated
from the features of the individual layers, leaving laborious measurements of individual combinations obsolete. For many materials, electrostatic attraction contributes strongly to overall FE for particles up to 100 nm diameter. Measurements with defined leaks
showed that already a small fractional leak area of 1–2% can strongly deteriorate total FE. This is especially the case for particles smaller than 5 µm diameter, where FE dropped by 50% or even two thirds. Our measurements show that by stacking an adequate
number of layers of many fabrics, decent filtration efficiencies can be reached for homemade face masks over large particle size ranges with acceptable pressure drop across the material. Very important, however, is good fit of the masks to minimize leak flows
and selection of non-hazardous mask material. © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. |
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Drywień, ME, Hamulka, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
The aim of the study was to identify the body weight changes and their determinants in the nutritional and socio-demographic
context during the COVID-19 pandemic in Polish women. During lockdown in Poland, 34% of women gained weight, while 18% of women reduced weight. As many as 44% of women with obesity before the pandemic increased their body weight, and 74% of women that were
underweight reduced their body weight. |
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Unfractionated Heparin in SARS-CoV-2 Pneumonia: Ischemic Stroke Case Report |
Efendizade, A, Dmytriw, et al |
Frontiers in Neurology |
Clinical data| Données cliniques |
We present a patient with COVID-19 pneumonia who was managed with unfractionated heparin (UFH) infusion and developed
a large ischemic infarct shortly after cessation of the infusion. In retrospect, the patient's coagulation parameters were consistent with overt DIC, although some of these parameters are easily masked by the effects of UFH. These findings emphasize the importance
of anticoagulation as well as its careful discontinuation, as failure to do so may result in a significant thromboembolic event. |
|
Ejima, Keisuke, Koizumi, et al |
medRxiv |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
This study investigated the influence of the COVID-19 pandemic on HIV testing and its consequences in Japan. The number
of HIV tests (9,584 vs. 35,908 in the year-before period) and consultations (11,689 vs. 32,565) performed by public health centers significantly declined in the second quarter of 2020, while the proportion of HIV cases with AIDS diagnosis among all HIV cases
(36.2% vs. 26.4%) significantly increased after removing the trend and seasonality effects. The number of HIV cases without AIDS diagnosis numerically decreased (166 vs. 217), although the reduction was not significant. Also confirmed similar trend for the
MSM and non-Japanese groups. |
|
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El Sayed, M, Al Qubati, et al |
Mathematical Biosciences and Engineering |
Modelling/ prediction| Modélisation/prédiction Healthcare Response | Réponse des soins
de santé |
The main goal of the present paper is to introduce a new approach to modify and generalize soft rough sets. We are
discussing and exploring the basic properties for these approaches. In addition, we use the suggested approaches as a mathematical modeling for an uncertain data and deal with the ambiguity. Comparisons among the proposed methods and the previous one are obtained.
Finally, a medical application of the suggested approximations in decision making of diagnosis of COVID-19 is illustrated. Moreover, we develop an algorithm following these concepts and apply it to a decision making problem to demonstrate the applicability
of the proposed methods. |
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|
Elliott, JA, Kenyon, et al |
British Journal of Surgery |
Epidemiology| Épidémiologie Transmission |
The aim of the present study was to use national administrative data National Quality Assurance Improvement System
of Ireland data set to estimate perioperative SARS‐CoV‐2 infection and mortality risk, relative to nosocomial transmission rates. The impact of nosocomial transmission was greatest after major emergency surgery, whereas laparoscopic surgery may be protective
owing to reduced duration of hospital stay. Procedure‐specific risk estimates are provided to facilitate surgical decision‐making and informed consent. |
|
|
Fan, H, Nie, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique Economics | Économie |
This study evaluates the impact of unemployment and government financial assistance during the COVID-19 pandemic on
the working-age population’s mental health and further examines the differential impacts between urban and non-urban groups, as well as African American (AA) and non-African American groups. |
|
|
Fang, S, Wang, et al |
International immunopharmacology |
Clinical data| Données cliniques |
The authors set out to describe the humoral immune feature of patients with coronavirus disease 2019. Low level of
complement C3 may be an alert to the admitted COVID-19 patients with additional management. |
|
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Carbapenemase-producing Enterobacterales outbreak:
Another dark side of COVID-19 |
Farfour, E, Lecuru, et al |
American Journal of Infection Control |
Healthcare Response | Réponse des soins de santé |
In the hospital department dedicated to COVID-19-patient, infection prevention and control measures were upgraded.
Therefore, the cross-transmission of other micro-organisms was thought unlikely to occur. However, we report an outbreak of NDM-5-producing Escherichia. coli in a 12-beds ICU dedicated to COVID-19 patients. This outbreak involved 6 patients of which 5 were
asymptomatic carriers and 1 was infected. Several findings might have contributed to cross-transmission including the multiple-bedroom configuration of the department, uncomplete compliance for standard and contact precautions, overwork due to the burden of
the disease, lack of training of staff for the care of ICU-patients, and misuse of gloves. Furthermore, as infection prevention and control measures were thought to be applied, contact patients were not screened for eXDR carriage. Applying rigorously standard
and contact precautions and performing screening in contact patients when indicated must be the rules in COVID-19 wards. © 2020 Association for Professionals in Infection Control and Epidemiology, Inc. |
|
Fei, F, Smith, et al |
Journal of medical virology |
Clinical data| Données cliniques |
Investigated the demographic, clinical, and laboratory characteristics in suspected COVID-19 patients admitted to the
University of Alabama at Birmingham. Fifty patients suspected with COVID-19 were included in our study, of whom 24 patients were positive with severe acute respiratory syndrome coronavirus-2 infection and 26 were negative. During the observation period, 30
patients were discharged, 17 died during hospitalization, and three remained in hospital. Compared to non-COVID-19 patients, COVID-19 patients had older age, more comorbidities, and elevated levels of inflammation markers such as erythrocyte sedimentation
rate (ESR), C-reactive protein (CRP), serum ferritin, and lactate dehydrogenase (LDH). However, there was no significant difference in laboratory data between survivors and nonsurvivors in COVID-19 patients in our study. |
|
|
A study
of consumers' attention on ⇜food nutrition⇝ during the COVID-19 outbreak |
Fengcai, MA, Qiannan, et al |
Boletin de Malariologia y Salud Ambiental |
Public Health response| Interventions de santé publique |
In the context of the covid-19 epidemic, this paper investigated consumers' concerns about food nutrition through an
online questionnaire. Logistic model was used to analyze the factors influencing consumers' attention to food nutrition. The results show that: the level of consumer education, whether there are children aged 15 and under or elderly aged 65 and over in the
family, the extent to which consumers understand food nutrition, the extent to which consumers' understanding how food nutrition improves their immunity, the government's efforts to regulate food safety, the extent to which the government popularization and
publicity food nutrition, the extent to which the media and advertisements publicity the nutrition of food, the prevalence of food nutrition in the community, have significant positive impact on consumers' attention to food nutrition. According to the research
results, some measures were proposed, such as improving consumers' subjective consciousness and cognition level, giving play to the information-oriented role of new media and communities, and strengthening the government's propaganda and supervision on food
nutrition. |
|
Ferriani, F, Natoli, et al |
Applied Economics Letters |
Economics | Économie |
This study analyzes whether investors take risks related to environmental, social and governance (ESG) factors into
account when making portfolio decisions. We exploit the new Morningstar’s ESG risk indicators–introduced at the end of 2019–to estimate the effect of ESG risk perception on investment fund flows. Our exercise, related to the early phase of the Covid-19 crisis
when uncertainty skyrocketed, shows that investors have preferred low-ESG-risk funds, with environmental risks remaining a top concern. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
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Understanding the value of clinical symptoms of COVID-19.
A logistic regression model |
Fleitas, Pedro Emanuel, Paz, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
This study described the main symptoms associated with COVID-19 to aid in the clinical diagnosis for the rapid identification
of cases. Multivariate logistic regression analyses showed that out of a total of 23 symptoms, only five were found to have a positive association with COVID-19: anosmia (odds ratio OR] 10.40, 95% confidence interval CI] 8.20-13.10, <56 group; OR 6.09 CI 3.05-12.20,
≥56 group), dysgeusia (OR 3.67, CI 2.7-4.9, <56 group; OR 3.53 CI 1.52-8.18, ≥56 group), low grade fever (37.5-37.9 °C) (OR 1.61, CI 1.20-2.05, <56 group; OR 1.80 CI 1.07-3.06, ≥56 group), cough (OR 1.20, CI 1.05-1.38, <56 group; OR 1.37 CI 1.04-1.80, ≥56
group) and headache only in <56 group (OR 1.71, CI 1.48-1.99). In turn, at the time of presentation, the symptoms associated with respiratory problems: chest pain, tachypnea, dyspnea, respiratory failure and use of accessory muscles for breathing, had a negative
association with COVID-19 (OR <1) or did not present statistical relevance (OR = 1). With the intention of helping the clinical diagnosis, designed a model to be able to identify possible cases of COVID-19. This model included 16 symptoms, the age and sex
of the individuals, and was able to detect 80% of those infected with SARS-CoV-2 with a specificity of 46%. |
|
Friedman, J, Calderón-Villarreal, et al |
Annals of Emergency Medicine |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
We assess how emergency medical services (EMS) data can be used in a sentinel capacity in Tijuana. In this observational
study, we calculated numbers of weekly out-of-hospital deaths and respiratory cases handled by EMS in Tijuana, and estimated the difference between peak epidemic rates and expected trends based on data from 2014 to 2019. An estimated 194.7 excess out-of-hospital
deaths (95% confidence interval 135.5 to 253.9 deaths) occurred during the peak window (April 14 to May 11), representing an increase of 145% (95% CI 70% to 338%) compared with expected levels. During the same window, only 5 COVID-19–related out-of-hospital
deaths were reported in official statistics. This corresponded with an increase in respiratory cases of 236.5% (95% CI 100.7% to 940.0%) and a decrease in mean SpO2 to 77.7% from 90.2% at baseline. The highest out-of-hospital death rates were observed in low-socioeconomic-status
areas, although respiratory cases were more concentrated in high-socioeconomic-status areas. |
|
|
Fuchs, A, Matonóg, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
The main finding of our study was the influence of COVID−19 pandemic on the quality of sexual lifestyle and frequency
of intercourse among Polish women. |
|
|
Early Prediction of COVID-19 Severity Using Extracellular
Vesicles and Extracellular RNAs |
Fujita, Yu, Hoshina, et al |
medRxiv |
Clinical data| Données cliniques |
Since emerging evidence indicates that extracellular vesicles (EVs) and extracellular RNAs (exRNAs) are functionally
involved in a number of pathological processes, this study hypothesized that these extracellular components may be key determinants and/or predictors of COVID-19 severity. Collected serum samples from 31 patients with mild COVID-19 symptoms at the time of
their admission. After standard therapy without corticosteroids, 9 of the 31 patients developed severe COVID-19 symptoms. Analyzed EV protein and exRNA profiles to look for correlations between these profiles and COVID-19 severity. And identified three distinct
groups of markers (antiviral response-related EV proteins, coagulation-related markers, and liver damage-related exRNAs) with the potential to serve as early predictive biomarkers for COVID-19 severity. Among these markers, EV COPB2 has the best predictive
value for severe deterioration of COVID-19 patients in this cohort. |
|
Galicia, PRB |
Hamdard Islamicus |
Public Health response| Interventions de santé publique |
This descriptive-correlational study aimed at determining the students' level of knowledge, attitude, and practices
on response measures toward COVID-19 in Antique as bases for development of health intervention program. The study found out that, generally, maritime students' had adequate level of knowledge, and positive attitude on response measures toward COVID-19. They
also shared common practices: they stay at home all the time, they cover their mouth with face mask while talking to people, and they wash their hands with antibacterial soap and clean water. On the other hand, they also shared least common practices: they
go to public places, they plant healthy vegetables, and they communicate with friend through social media. |
|
|
The COVID-19 pandemic and its impact on homebound nursing students |
Gallego-Gómez, JI, Campillo-Cano, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
Our purpose was to assess the stress levels of Nursing students before and during lockdown due to the COVID-19 pandemic
in Murcia (Spain), its influence on taking an online exam and how it was affected by physical exercise. At 40 days of lockdown, those students with financial, family or emotional problems, and less physical exercise reported significantly higher stress levels.
In addition, those who passed the online exam had lower stress levels compared to those who failed. |
|
Gaudou, B, Huynh, et al |
Frontiers in Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission
Public health interventions*| Interventions de santé publique |
We present in this paper an agent-based modeling framework called COVID-19 Modeling Kit (COMOKIT), designed to be generic,
scalable and thus portable in a variety of social and geographical contexts. COMOKIT combines models of person-to-person and environmental transmission, a model of individual epidemiological status evolution, an agenda-based 1-h time step model of human mobility,
and an intervention model. Several large-scale experiments are analyzed in this paper to compare the impact of public health policies in different scenarios. |
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Lebanese Doctors Facing the SARS-CoV-2 Pandemic: Practical and Ethical
Issues |
Gebara, Nicole, Dabar, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
We aimed in this study to assess Lebanese physicians’ attitudes, practice and ethical considerations when treating
their patients during the COVID-19 pandemic. A total of 318 physicians responded, with a mean age of 40 years. Five doctors of the total were affected by the COVID-19 infection (1.6%). 51.4% of medical specialists considered themselves to be at a higher risk
of contracting the infection, while 52.3% of surgeons stated that they were at a lower risk. Doctors were neutral regarding treating patients according to any priority and discontinuing the ventilation of any patient with bad prognosis. The majority of doctors
disagreed regarding the respect of the patient’s autonomy in refusing COVID-19 treatment with a mean score of 1.7/5. Finally, doctors expressed a neutral opinion regarding the ability of the country to manage such a pandemic with a mean score of 3.1/5. |
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Cytokine profile and disease severity in patients with COVID-19 |
Ghazavi, A, Ganji, et al |
Cytokine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to evaluate the serum levels of interferon (IFN)-γ, interleukin (IL)-5, IL-8, Il-9, IL-17,
TGF-β and IFN-γ in patients infected with SARS-CoV-2. Data suggest that TGF-β can be used as a predictive factor of disease severity in patients with COVID-19. |
|
Gheware, Atish, Dholakia, et al |
Research Square prepub |
Therapeutics| Thérapeutique Animal model | Modèle animal |
In this study we tested the effect of whole aqueous extract Adhatoda Vasica (AV), that our group has shown to have
anti-hypoxic and anti-inflammatory effects, on various outcomes of hypoxic response. Effects of AV were assessed in preclinical mouse models of pulmonary fibrosis, bacterial sepsis and siRNA induced hypoxia-thrombosis phenotype. Oral administration AV extract
attenuated the increased levels of airway inflammation, collagen content, transforming growth factor-β1 (TGF-β1), IL-6, HIF-1α and improved the overall survival rate in bleomycin treated and Cecum Ligation and Puncture (CLP) induced mice. AV treatment also
rescued the prolyl hydroxylase domain 2 (phd2) siRNA induced HIF-1α and associated blood coagulation phenotypes in mice. Transcriptome analysis of lungs of AV treated naïve mice reveal downregulation of hypoxia, inflammation, TGF-β1 and angiogenesis and upregulation
of adaptive immunity related genes. These genes and pathways show opposite expression in transcriptome of BALF and PBMCs of SARS-CoV2 infected patient. Molecular docking of AV constituents presents in extract reveal many molecules with low binding energy (≤
-8) to multiple SARS-CoV2 and host target proteins that are relevant in viral entry and replication. |
|
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Giardino, DL, Huck-Iriart, et al |
Sleep medicine |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to evaluate the impact of the long period of mandatory social isolation that took place
in Argentina on the general psychological well-being of healthcare workers due to the COVID-19 pandemic. An extremely high proportion of Argentinian healthcare workers suffered from sleep problems, anxiety, and depression symptoms. |
|
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Spontaneous rectal perforation in a patient with SARS–CoV-2 infection |
Giuffrè, M, Bozzato, et al |
Journal of Personalized Medicine |
Clinical data| Données cliniques |
Here, we present in detail the first case of rectal perforation in a patient with COVID-19. |
|
Giuffrè, M, Di Bella, et al |
Tropical Medicine and Infectious Disease |
Clinical data| Données cliniques |
The current pilot study aims at evaluating fecal calprotectin (FC) concentrations in patients without gastrointestinal
symptoms. At admission, 21 patients showed increased FC despite absent gastrointestinal symptoms. We found a strong positive correlation between FC and D-Dimer. Two patients developed bowel perforation. |
|
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Guan, J, Wei, et al |
International immunopharmacology |
Clinical data| Données cliniques Immunology | Immunologie |
Authors aim to investigate the dynamic changes of immune status in COVID-19 patients with clinical evolution. The
immune status of COVID-19 patients is different in each stage, and dynamic monitoring of related indicators can help predict the disease and may avoid cytokine storms. |
|
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Habel, JR, Nguyen, et al |
Proceedings of the National Academy of Sciences of the United States of America |
Coronavirology| Coronavirologie Immunology | Immunologie |
vere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the clonal expansion of SARS-CoV-2−specific CD8+
and CD4+ T cells in vitro, with CD4+ T cells being robust. We identified two HLA-A*02:01-restricted SARS-CoV-2-specfic CD8+ T cell epitopes, A2/ S269-277 and A2/Orf1ab3183-3191. Using peptide−HLA tetramer enrichment, direct ex vivo assessment of A2/S269+CD8+
and A2/ Orf1ab3183+CD8+ populations indicated that A2/S269+CD8+ T cells were detected at comparable frequencies (∼1.3
× 10−5) in acute and convalescent HLA-A*02:01+ patients. These frequencies were higher than those found in uninfected HLA-A*02:01+ donors (∼2.5
× 10−6), but low when compared to frequencies for influenza-specific (A2/M158) and Epstein-Barr virus (EBV)-specific (A2/BMLF1280) (∼1.38
× 10−4) populations. Phenotyping A2/S269+CD8+ T cells from COVID-19 convalescents ex vivo showed that A2/S269+CD8+ T cells were predominantly negative for CD38, HLA-DR, PD-1, and CD71 activation markers, although the majority of total CD8+ T cells expressed
granzymes and/or perforin. Furthermore, the bias toward naïve, stem cell memory and central memory A2/S269+CD8+ T cells rather than effector memory populations suggests that SARS-CoV-2 infection may be compromising CD8+ T cell activation. |
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Habib, Y, Xia, et al |
Environment, Development and Sustainability |
Economics | Économie |
This paper endeavors to analyze and provide fresh global insights from the asymmetric nexus between the recent outbreak
of COVID-19, crude oil prices, and atmospheric CO2 emissions. The analysis employs a unique Morlet’s wavelet method. More precisely, this paper implements comprehensive wavelet coherence analysis tools, including continuous wavelet coherence, partial wavelet
coherence, and multiple wavelet coherence to the daily dataset spanning from December 31, 2019 to May 31, 2020. From the frequency perspective, this paper finds significant wavelet coherence and vigorous lead and lag connections. This analysis ascertains significant
movement in variables over frequency and time domain. These results demonstrate strong but varying connotations between studied variables. The results also indicate that COVID-19 impacts crude oil prices and the most contributor to the reduction in CO2 emissions
during the pandemic period. |
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An Android-based application for convenient visitation at windhoek correctional facility |
Haiduwa, T, Hashiyana, et al |
|
Public Health response| Interventions de santé publique |
Authors of this paper developed an android-based application to support social distancing, help Namibians in locating
their relatives and friends in Namibian rehabilitation centers and reduce recidivism while improving the morale and safety of inmates and workers amid the pandemic. This study adopted a mixed research methodology with a case study and an experimental as a
research design. An Agile software development model has been used for the development of an application. Primary data were collected through open-ended questionnaires, direct observations in the prison and group interviews. The study has been also chiefly
informed by related literature reviews, as secondary data. A simple random sampling technique has been used to select the respondents from a target population of thirty participants. The study concluded that the application developed was intelligent, innovative,
helpful, easy and convenient to use. Mobile technology can drastically change how we can communicate. It has been recommended that the Ministry of Home Affairs, Safety and Security consider funding and fully implement this project in all thirteen correctional
facilities across the country. As part of future work, a similar version of iOS is to be developed and possibly implement a remote and/or onsite Inmate video visitation. |
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Impact of COVID-19 on Online Gambling – A General Population Survey During the Pandemic |
Håkansson, A |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
Given the need for objective data about gambling behavior during the pandemic, the present analysis, from a project
assessing online gambling in Sweden, aimed to study past-30-day gambling patterns in online gamblers in Sweden. Past-30-day gambling for several gambling types was lower compared to a previous study in online gamblers in the same setting, while online non-sports
gambling remained at high levels. Those reporting sports betting even during a period with decreased sports betting occasions proved to have markedly higher gambling problems. |
|
Harris, R |
Health and Place |
Epidemiology| Épidémiologie |
This paper explores neighbourhood-level correlates of the Covid-19 deaths in London during the initial rise and peak
of the pandemic within the UK – the period March 1 to April 17, 2020. It asks whether the person-level predictors of Covid-19 that are identified in reports by Public Health England and by the Office of National Statistics also hold at a neighbourhood scale,
remaining evident in the differences between neighbours. In examining this, the paper focuses on localised differences in the number of deaths, putting forward an innovative method of analysis that looks at the differences between places that share a border.
Specifically, a difference across spatial boundaries method is employed to consider whether a higher number of deaths in one neighbourhood, when compared to its neighbours, is related to other differences between those contiguous locations. It is also used
to map localised ‘hot spots’ and to look for spatial variation in the regression coefficients. The results are compared to those for a later period, April 18 – May 31. The findings show that despite some spatial diffusion of the disease, a greater number of
deaths continues to be associated with Asian and Black ethnic groups, socio-economic disadvantage, very large households (likely indicative of residential overcrowding), and fewer from younger age groups. The analysis adds to the evidence showing that age,
wealth/deprivation, and ethnicity are key risk factors associated with higher mortality rates from Covid-19. |
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He, Zhesheng, Ye, et al |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
Our SARS-CoV-2 main protease (Mpro) crystal structure studies revealed Au(I), derived from auranofin (AF) or gold cluster
(GA), could specifically bind thiolate of Cys145 of SARS-CoV-2 Mpro. GA or AF could well inhibit Mpro activity and significantly decrease SARS-CoV-2 replication in cell. Cell studies showed that either AF or GA could down-regulate NFκB pathway, therefore significantly
inhibit inflammatory cytokine level of IL-6, IL-1β, TNF-α in macrophage and bronchial epithelial cell, respectively. The lung viral load in GA treated COVID-19 mice (15mg/kg.bw) is significantly lower than that in normal saline (NS, 0.9% NaCl) treated COVID-19
mice, and pathological studies revealed GA treatment (score ~1.8) significantly reduced lung inflammatory injury compared with NS treated COVID-19 mice (score ~3). After normal mice were treated by GA (15mg/kg), the Au ingredient well distributed into lungs
and there are no pathological changes in main organs when compared with control mice. The toxicity results revealed GA is more safety than auranofin for cell/mice/rat. The rat pharmacokinetics studies show GA is with high bioavailability (> 90%) in vivo. |
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Hendy, A, Abozeid, et al |
Nursing Open |
Healthcare Response | Réponse des soins de santé |
Examined predictive factors affecting stress among nurses providing care at COVID-19 Isolation Hospitals at Egypt.
52.1% of studied nurses had moderate level of total nursing stress scale. Also, 26.2% of them had severe level, while 13.4% & 8.3% of them had mild and normal level, respectively. Mean SD score of studied nurses regarding to total nursing stress scale was
99.47 ± 10.671. Training for COVID-19, availability of PPE, educational level and attention of hospital administration were negative predictor factors for nurses’ stress, while having children, people showed that COVID-19 is stigma, fears of infection, workplace,
fear of transmission infection for family and nurse to patient ratio were positive predictors. |
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Hernandez-Vargas, E, Velasco-Hernandez, et al |
Annual Reviews in Control |
Coronavirology| Coronavirologie Immunology | Immunologie |
Here, we contribute to the mathematical study of SARS-CoV-2 dynamics at the within-host level based on data presented
by Wölfel et al. (2020). Based on the target cell limited model, the within-host reproductive number for SARS-CoV-2 is consistent with the broad values of human influenza infection. The best model to fit the data was including immune cell response, which suggests
a slow immune response peaking between 5 to 10 days post-onset of symptoms. The model with the eclipse phase, time in a latent phase before becoming productively infected cells, was not supported. Interestingly, model simulations predict that SARS-CoV-2 may
replicate very slowly in the first days after infection, and viral load could be below detection levels during the first 4 days post infection. |
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Modelling SARS-CoV-2 transmission in a UK university
setting |
Hill, EdwardM, Atkins, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We constructed a network-based model to capture the interactions of a student population in different settings (housing,
social and study). For a single academic term of a representative campus-based university, we ran a susceptible-latent-infectious-recovered type epidemic process, parameterised according to available estimates for SARS-CoV-2. We investigated the impact of:
adherence to (or effectiveness of) isolation and test and trace measures; single-room isolation of cases; supplementary mass testing. Results: Incorporating uncertainty in the asymptomatic fraction of cases and their associated infectivity, in the absence
of interventions our model estimated that 16% (2% - 38%) of the student population could be infected during the autumn term. With full adherence to test, trace and isolate measures, we found lower cumulative infection estimates of 1.4% (0.4% - 5%). Irrespective
of the adherence to isolation measures, on average a higher proportion of students resident on-campus became infected than off-campus. Room isolation generated minimal benefits. A one-off instance of mass testing would not drastically reduce the term-long
case load or end-of-term prevalence, but regular weekly or fortnightly testing could reduce both measures by more than 50% (compared to having no mass testing). |
|
Hirashima, T, Arai, et al |
Journal of Infection and Chemotherapy |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We retrospectively examined significant factors associated with disease severity in symptomatic COVID-19 patients (COVID-Pts)
admitted to our institution between February 20 and April 30, 2020. COVID-Pts were categorized as those with critical or severe illness (Pts-CSI) or those with moderate or mild illness (Pt-MMI). All statistical analyses were performed using R software. Data
from 61 patients (16 Pt–CSI, 45 Pt-MMI), including 58 Japanese and three East Asians, were analyzed. Pt–CSI were significantly older and had hypertension or diabetes than Pt-MMI (P < 0.001, 0.014 and < 0.001, respectively). Serum albumin levels were significantly
lower in Pt–CSI than in Pt-MMI (P < 0.001), whereas the neutrophil-to-lymphocyte ratio and C-reactive protein level were significantly higher in Pt–CSI than in Pt-MMI (P < 0.001 and P < 0.001, respectively). In the CT images of 60 patients, bilateral lung
lesions were more frequently observed in Pt–CSI than in Pt-MMI (P = 0.013). Among the 16 Pt–CSI, 15 received antiviral therapy, 12 received tocilizumab, five underwent methylprednisolone treatment, six received mechanical ventilation, and one died. The illness
severity of Japanese COVID-Pts was associated with older age, hypertension and/or diabetes, low serum albumin, high neutrophil-to-lymphocyte ratio, and C-reactive protein. |
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Hjálmsdóttir, A, Bjarnadóttir, et al |
Gender, Work and Organization |
Public Health response| Interventions de santé publique |
This article explores the gendered realities of work–life balance in Iceland during the COVID-19 pandemic, in particular
how these societal changes reflect and affect the gendered division of unpaid labor, such as childcare and household chores. The study draws on open-ended real-time diary entries, collected for 2 weeks during the peak of the pandemic in Iceland. The entries
represent the voices of 37 mothers in heteronormative relationships. The findings imply that, during the pandemic, the mothers took on greater mental work than before. They also described intense emotional labor, as they tried to keep everyone calm and safe.
The division of tasks at home lay on their shoulders, causing them stress and frustration. The findings suggest that, even in a country that has been at the top of the Gender Gap Index for several years, an unprecedented situation like COVID-19 can reveal
and exaggerate strong gender norms and expectations toward mothers. |
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Hossain, E, Bhadra, et al |
Physics of Fluids |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
In this report, we summarize our results on the development of a simple laboratory setup allowing measurement of charge
and filtration efficiency in N95 masks. In particular, we propose and show that it is possible to recharge the masks post-decontamination and recover filtration efficiency. |
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Uncertainty in the impact of the COVID-19 pandemic on air quality in Hong Kong, China |
Huang, Y, Zhou, et al |
Atmosphere |
Public health interventions*| Interventions de santé publique |
In this study, we evaluated the effect of the COVID-19 lockdown on the roadside and ambient air quality in Hong Kong,
China, by comparing the air quality monitoring data collected in January-April 2020 with those in 2017-2019. The results showed that the roadside and ambient NO2, PM10, PM2.5, CO and SO2 were generally reduced in 2020, while O3 was increased. |
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In silico drug discovery of major metabolites from spices as SARS-CoV-2 main
protease inhibitors |
Ibrahim, MAA, Abdelrahman, et al |
Computers in biology and medicine |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, we investigate metabolites present in several common spices as possible inhibitors of COVID-19. Specifically,
32 compounds isolated from 14 cooking seasonings were examined as inhibitors for SARS-CoV-2 main protease (Mpro), which is required for viral multiplication. Using a drug discovery approach to identify possible antiviral leads, in silico molecular docking
studies were performed. Docking calculations revealed a high potency of salvianolic acid A and curcumin as Mpro inhibitors with binding energies of −9.7 and −9.2 kcal/mol, respectively. Binding mode analysis demonstrated the ability of salvianolic acid A and
curcumin to form nine and six hydrogen bonds, respectively with amino acids proximal to Mpro's active site. Stabilities and binding affinities of the two identified natural spices were calculated over 40 ns molecular dynamics simulations and compared to an
antiviral protease inhibitor (lopinavir). Molecular mechanics-generalized Born surface area energy calculations revealed greater salvianolic acid A affinity for the enzyme over curcumin and lopinavir with energies of −44.8, −34.2 and −34.8 kcal/mol, respectively.
Using a STRING database, protein-protein interactions were identified for salvianolic acid A included the biochemical signaling genes ACE, MAPK14 and ESR1; and for curcumin, EGFR and TNF. This study establishes salvianolic acid A as an in silico natural product
inhibitor against the SARS-CoV-2 main protease and provides a promising inhibitor lead for in vitro enzyme testing. |
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Ilesanmi, O, Afolabi, et al |
PeerJ |
Public Health response| Interventions de santé publique |
Assessed the perception and practices regarding COVID-19 among residents in selected urban communities of Ibadan, Oyo
State, Nigeria. Going to the hospital (95%) and calling the COVID-19 help number (58.3%) were the frequently reported practices among respondents following the development of COVID-19 symptoms. Also, 26% knew they could contract COVID-19, while 12% perceived
it as an exaggerated event. The effects most frequently reported by respondents were hunger/low income (48.8%) and academic delay (8.8%). Use of face masks by 64.5% and social distancing (48%) were the most frequently reported practices for prevention. Only
20.8% demonstrated good handwashing practices. The perception of the likelihood to contract COVID-19 and practices to prevent COVID-19 had a weak correlation. |
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Ilonzo, N, Rao, et al |
Journal of Vascular Surgery |
Clinical data| Données cliniques |
Highlight the unique treatment required for patients suffering acute thrombotic events and discussed the role of anticoagulation
for patients diagnosed with COVID-19. A total of 21 patients with acute thrombotic events met our inclusion and exclusion criteria. Most cases were acute arterial events (76.2%), with the remainder venous cases (23.8%). The average age for all patients was
64.6 years, and 52.4% were male. The most prevalent comorbidity in the group was hypertension (81.0%). Several markers were markedly abnormal in both arterial and venous cases, including an elevated neutrophil/lymphocyte ratio (8.8) and D-dimer level (4.9
μg/mL). Operative intervention included percutaneous angiography in 25.00% of patients and open surgical embolectomy in 23.8%. Most of the patients who had undergone arterial intervention had developed a postoperative complication (53.9%) compared with a 0%
complication rate after venous interventions. Acute kidney injury on admission was a factor in 75.0% of those who died vs 18.2% in the survivors. |
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Effect of meteorological factors on COVID-19 cases in Bangladesh |
Islam, ARMT, Hasanuzzaman, et al |
Environment, Development and Sustainability |
Epidemiology| Épidémiologie Transmission |
Examinde the effects of Bangladesh's subtropical climate on coronavirus diseases 2019 (COVID-19) transmission. Significant
coherence between meteorological variables and COVID-19 at various time–frequency bands has been identified in this work. The results showed that the minimum (MinT) and mean temperature, wind speed (WS), relative humidity (RH) and absolute humidity (AH) had
a significant positive correlation while contact transmission had no direct association with the number of COVID-19 confirmed cases. |
|
Jagtap, Dhanashree, Bhor, et al |
medRxiv |
Clinical data| Données cliniques |
This study aimed to evaluate the role of systemic and gut inflammatory markers in disease progression and development
of anti-viral humoral immunity following SARS-CoV-2 infection. Twenty eight of 36 (78%) in-patients and 19 of 22 (86%) convalescents were males. Out of 47 in-patient samples, 22 (46%), 11 (23%) and 14 (30%) were IgG-/IgM-, IgG+/IgM+ and IgG+/IgM- respectively.
Of 22 convalescent samples, 3 (14%), 1 (4%) and 17 (77%) were respectively IgG-/IgM-, IgG+/IgM+ and IgG+/IgM-. Two out of 22 (9%) convalescents showed high IL-6 levels (>100pg/ml) and 4 (18%) had high TNF levels (>30pg/ml). However, the convalescents (n =22)
had significantly lower levels of IL-6 Median=27.48 (IQR=23.54-39.92)] compared to followed up in-patients (n = 11) at day 0 Median=111(IQR=68-129.7), p =0.0002] and higher levels of sMAdCAM Median=1940 (1711-2174) pg/ml] compared to these individuals at day
0 Median=1701 (IQR=1532-1836) pg/ml; p=0.032] and day 7 Median=1534 (IQR=1236-1654) pg/ml; p=0.0007]. Further, IL-6 and sMAdCAM levels among in-patients inversely correlated with one another (r =-0.374, p = 0.009, CI = 95%). When expressed as a novel integrated
marker, sMIL (sMAdCAM/IL-6 ratio) index, these levels were incrementally and significantly higher across various disease states with convalescents exhibiting the highest values Median= 64.74 (IQR=47.33-85.58)]. Also, the sMIL index was significantly higher
in convalescents (with class-switched responses) compared to IgG+/IgM+ individuals at early stages of infection Median=28.65 (IQR=13.63-96.26), p = 0.034]. Real-time measurement by SPR of plasma antibody binding to viral nucleocapsid (NC), receptor binding
domain (RBD) and spike (S) revealed waxing and waning of plasma antibody responses to all 3 targets. Importantly, sMAdCAM levels as well as sMIL index (fold change) correlated with peak association rates of RBD-binding (r = 0.462, p = 0.03, CI = 95%) and fold
change in binding to S (r = 0.68, p = 0.050, CI = 95%) respectively. |
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Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2
3CL-Protease in Vitro |
Jang, M, Park, et al |
Evidence-based Complementary and Alternative Medicine |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this report, we demonstrated that EGCG and theaflavin, the main active ingredients of green tea and black tea, respectively,
are potentially effective to inhibit SARS-CoV-2 activity. Coronaviruses require the 3CL-protease for the cleavage of its polyprotein to make individual proteins functional. EGCG and theaflavin showed inhibitory activity against the SARS-CoV-2 3CL-protease
in a dose-dependent manner, and the half inhibitory concentration (IC50) was 7.58 μg/ml for EGCG and 8.44 μg/ml for theaflavin. In addition, we did not observe any cytotoxicity for either EGCG or theaflavin at the concentrations tested up to 40 μg/ml in HEK293T
cells. These results suggest that upon further study, EGCG and theaflavin can be potentially useful to treat COVID-19. |
|
Jarmoliński, T, Matkowska-Kocjan, et al |
Pediatric transplantation |
Clinical data| Données cliniques |
Here, we report a unique case of a child with viral pneumonia caused by coinfection with human metapneumovirus (MPV),
respiratory syncytial virus (RSV), and SARS‐CoV‐2 after hematopoietic stem cell transplantation. |
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Jindal, MK, Sar, et al |
Journal of Radioanalytical and Nuclear Chemistry |
Public Health response| Interventions de santé publique |
The study aimed to determine the impact of COVID-19 on values of annual effective dose equivalent of the natural gamma
dose rate of Balod, Durg and Bemetara districts of Chhattisgarh (India). The value of indoor gamma dose rates was reported to be higher in most places compared to the outdoor gamma dose rate, but in this pandemic situation, occupancy factor values are not
applicable as recommended by UNSCEAR for calculation of annual effective dose equivalent (AEDE). Therefore, the present study introduces the new equations, which can measure the extra AEDE value during lockdown for adults, children and infants. |
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|
Kale, Neil |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
It is important to develop methods that will ensure that the COVID vaccine is allocated to the people who are at major
risk until there is a sufficient global supply. Herein, I developed a machine-learning tool that could be applied to assess the risk in communities based on social, medical, and lifestyle risk factors. As a proof of concept, I modeled COVID risk in the Massachusetts
communities using 29 risk factors, including the prevalence of preexisting comorbid conditions like COPD and social factors such as racial composition. Of the 29 factors, 14 were found to be significant (p < 0.1) indicators: poverty, food insecurity, lack
of high school education, lack of health insurance coverage, premature mortality, population, population density, recent population growth, Asian percentage, high-occupancy housing, and preexisting prevalence of cancer, COPD, overweightness, and heart attacks.
The machine-learning approach finds the 9 highest risk communities in the state of Massachusetts: Lynn, Brockton, Revere, Randolph, Lowell, New Bedford, Everett, Waltham, and Fitchburg. The 5 most at-risk counties are Suffolk, Middlesex, Bristol, Norfolk,
and Plymouth. |
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COVID-19 In a Rural Health System in New York - Case
Series and an Approach to Management |
Kedar, Eyal, Scott, et al |
medRxiv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We completed a review of clinical data for patients who were treated by our inpatient COVID-19 treatment team between
March 20 and May 22, 2020. Twenty COVID-19 patients were identified. Sixteen patients (80%) met NIH criteria for severe or critical disease. One patient died. No patients were transferred to other hospitals. During the first two months of the pandemic, we
were able to manage hospitalized COVID-19 patients in our rural community. Development of similar treatment models in other rural areas should be considered. |
|
Patterns of the COVID-19 pandemic spread around the world: exponential versus power
laws |
Komarova, NL, Schang, et al |
Journal of the Royal Society, Interface |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We have analysed the COVID-19 epidemic data of more than 174 countries (excluding China) in the period between 22 January
and 28 March 2020. We found that some countries (such as the USA, the UK and Canada) follow an exponential epidemic growth, while others (like Italy and several other European countries) show a power law like growth. Regardless of the best fitting law, many
countries can be shown to follow a common trajectory that is similar to Italy (the epicentre at the time of analysis), but with varying degrees of delay. We found that countries with 'younger' epidemics, i.e. countries where the epidemic started more recently,
tend to exhibit more exponential like behaviour, while countries that were closer behind Italy tend to follow a power law growth. We hypothesize that there is a universal growth pattern of this infection that starts off as exponential and subsequently becomes
more power law like. |
|
Potential COVID-19 papain-like protease PLpro inhibitors: Repurposing FDA-approved drugs |
Kouznetsova, VL, Zhang, et al |
PeerJ |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Using the crystal structure of SARS-CoV-2 papain-like protease (PLpro) as a template, we developed a pharmacophore
model of functional centers of the PLpro inhibitor-binding pocket. With this model, we conducted data mining of the conformational database of FDA-approved drugs. This search identified 147 compounds that can be potential inhibitors of SARS-CoV-2 PLpro. The
conformations of these compounds underwent 3D fingerprint similarity clusterization, followed by docking of possible conformers to the binding pocket of PLpro. Docking of random compounds to the binding pocket of protease was also done for comparison. Free
energies of the docking interaction for the selected compounds were lower than for random compounds. The drug list obtained includes inhibitors of HIV, hepatitis C, and cytomegalovirus (CMV), as well as a set of drugs that have demonstrated some activity in
MERS, SARS-CoV, and SARS-CoV-2 therapy. We recommend testing of the selected compounds for treatment of COVID-19. Copyright 2020 Kouznetsova et al. |
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Pattern of liver function and clinical profile in COVID-19: A cross-sectional study
of 91 patients |
Kumar, A, Kumar, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Clinical data| Données cliniques |
The objective of this study was to analyse the liver function in patients with COVID-19 and their association with
respect to age, sex, severity of disease and clinical features. Liver injury is common in SARS-CoV-2 infection and is more prevalent in the severe disease group. |
|
Survey-Based Study
on Anxiety Disorder among Indians Due to the COVID-19 Global Pandemic |
Kumar, Ravi, Kumari, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
This study aims to find the level of anxiety of the people in India. A total of 758 participants has participated in
this online survey. Out of the total valid response, 486 (67.1%) were founded mild to moderate anxiety levels, and males found a higher anxiety level than females. Out of these, 50.3% felt breathing difficulty, and 62.9% o felt difficulty concentrating and
losing interest in doing work, and 66.8 % felt the change in sleeping patterns. In this study, we found that the anxiety level of those people who watch lots of news and think about the coronavirus is higher than the others. The main reason for people's anxiety
is getting infected by a coronavirus, and Worry about Future. |
|
Kurita, Junko, Sugawara, et al |
medRxiv |
Epidemiology| Épidémiologie |
We sought to quantify excess mortality in April using the National Institute of Infectious Diseases (NIID) model. We
applied the NIID model to deaths of all causes from 1987 up through July, 2020. Results show no significant excess mortality in March to July, 2020, when the COVID-19 outbreak affected Japan most. Because changes in application rule of the International Classification
of Diseases in 2017 affected the number of pneumonia deaths drastically, we were unable to use pneumonia deaths to estimate excess mortality. it might be important to continue to monitor excess mortality of COVID-19 carefully after July 2020. |
|
|
Laing, EricD, Sterling, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we describe the development and application of a multiplex microsphere-based immunoassay (MMIA) for COVD-19 antibody
studies, utilizing serum samples from non-human primate SARS-CoV-2 infection models, an archived human sera bank and subjects enrolled at five U.S. military hospitals. The MMIA incorporates prefusion stabilized spike glycoprotein trimers of SARS-CoV-2, SARS-CoV-1,
MERS-CoV, and the seasonal human coronaviruses HCoV-HKU1 and HCoV-OC43, into a multiplexing system that enables simultaneous measurement of off-target pre-existing cross-reactive antibodies. We report the sensitivity and specificity performances for this assay
strategy at 98% sensitivity and 100% specificity for subject samples collected as early as 10 days after the onset of symptoms. In archival sera collected prior to 2019 and serum samples from subjects PCR negative for SARS-CoV-2, we detected seroprevalence
of 72% and 98% for HCoV-HKU1 and HCoV-0C43, respectively. Requiring only 1.25 uL of sera, this approach permitted the simultaneous identification of SARS-CoV-2 seroconversion and polyclonal SARS-CoV-2 IgG antibody responses to SARS-CoV-1 and MERS-CoV, further
demonstrating the presence of conserved epitopes in the spike glycoprotein of zoonotic betacoronaviruses. |
|
|
Lauriola, M, Pani, et al |
Clinical and Translational Science |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Performed a retrospective single-center cohort study including 377 consecutive patients admitted for pneumonia related
to COVID-19. Of these, 297 were in combination treatment, 17 were on HCQ alone, and 63 did not receive either of these 2 drugs because of contraindications. We recorded 146 deaths: 35 in no treatment, 7 in HCQ treatment group, and 102 in HCQ + azithromycin
treatment group. At multivariable Cox proportional hazard regression analysis, age, mechanical ventilation/continuous positive airway pressure, and C reactive protein above the median were directly associated with death, whereas use of HCQ + azithromycin (vs.
no treatment) was inversely associated. In this study, we found a reduced in-hospital mortality in patients treated with a combination of HCQ and azithromycin after adjustment for comorbidities. |
|
|
Lemmin, T, Kalbermatter, et al |
Journal of Structural Biology: X |
Coronavirology| Coronavirologie |
In this study, multi-microsecond molecular dynamics simulations and ab initio modeling were leveraged to gain insights
into the structures and dynamics of the loop containing the S1/S2 protease cleavage site. In most conformations, this loop protrudes from the spike, thus representing an attractive SARS-CoV-2 specific therapeutic target. |
|
|
Li, Xun, Lai, et al |
medRxiv |
Epidemiology| Épidémiologie |
Less than 5 percent of Chinese cities had top-ranked officials with public health or medical backgrounds (PHMBGs).
Does professionalism improve their response to a public crisis like the COVID-19 pandemic? Collecting resumes of government and Party officials in almost all prefectural Chinese cities, and matching with other data sources, including weather conditions, city
characteristics, COVID-19-related policies, and health outcomes, we demonstrate that cities 15 whose top officials had PHMBGs witnessed significantly lower infection rates, and often lower death rates, than cities whose top officials lacked such backgrounds.
Mechanism testing suggests that the effects were at least partially explained by more rapid lockdown or community closure. Our findings offer insights into better preparation for future epidemics via improving leadership team composition, particularly recruiting
major officials with PHMBGs. |
|
|
Limbers, CA, McCollum, et al |
Mental Health and Physical Activity |
Public Health response| Interventions de santé publique |
The purpose of the current cross-sectional study was to evaluate the associations between parenting stress, quality
of life, and physical activity in a national sample of working mothers who endorsed having been forced to work from home full-time due to the COVID-19 pandemic and examine if physical activity moderates the association between parenting stress and quality
of life in this sample of working mothers. After controlling for socio-demographic variables (i.e., maternal marital status, annual income, maternal highest level of education), greater parenting stress was associated with poorer maternal quality of life across
domains (standardized beta coefficients ranged from −0.26 to −0.47; p < .001). The interaction between parenting stress and moderate intensity physical activity was associated with social relationships quality of life and environment quality of life (standardized
beta coefficients ranged from 0.15 to 0.17; p < .05) in our sample of working mothers. The negative effect of parenting stress on maternal social relationships and environmental quality of life was weaker for working mothers who engaged in higher levels of
moderate intensity physical activity. |
|
|
Liu, Ji, Huang, et al |
medRxiv |
Public Health response| Interventions de santé publique |
In this paper, we analyze the public reactions to the pandemic using search engine data and mobility data from Baidu
Search and Baidu Maps respectively, where we particularly pay attentions to the early stage of pandemics and find early signals from the collective response to COVID-19. First, we correlate the number of confirmed cases per day to daily search queries of a
large number of keywords through Dynamic Time Warping (DTW) and Detrended Cross-Correlation Analysis (DCCA), where the keywords top in the most critical days are believed the most relevant to the pandemic. We then categorize the ranking lists of keywords according
to the specific regions of the search, such as Wuhan, Mainland China, the USA, and the whole world. Through the analysis on search, we succeed in identifying COVID-19 related collective response would not be earlier than the end of 2019 in Mainland China.
Finally, we confirm this observation again using human mobility data, where we specifically compare the massive mobility traces, including the real-time population densities inside key hospitals and inter-city travels departing from/arriving in Wuhan, from
2018 to 2020. No significant changes have been witnessed before December, 2019. |
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Strategies for the development of drugs targeting novel coronavirus 2019-nCoV |
Liu, QY, Wang, et al |
Yaoxue Xuebao |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Article in Chinese. Using bioinformatics and database analysis, we have identified 75 clinically compounds, including
20 marketed compounds, that are efficacious in inhibiting key targets in virus- and host-based approaches, which may facilitate the development of new therapeutic options for 2019-nCoV. |
|
Lo, HY, Chaou, et al |
American Journal of Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
The goal of the current study was to detect specific patterns of change in emergency department (ED) volume and severity
during a pandemic which would help to arrange medical staff and utilize facilities and resources in EDs in advance in the event of a future pandemic. This was a retrospective study of the patients who visited our ED between November 1, 2019 and April 30, 2020.
We evaluated the change in ED patient volume and complexity of patients in our medical record system. Patient volume and severity during various periods were identified and compared with data from the past 3 years and the period that SARS occurred. A reduction
in ED volume was evident. The reduction began during the early epidemic period and increased rapidly during the peak period of the epidemic with the reduction continuing during the late epidemic period. No significant difference existed in the percentages
of triage levels 1 and 2 between the periods. The admission rate, length of stay in the ED, and average number of patients with out-of-hospital cardiac arrest increased during the epidemic periods. |
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Saliva as a promising biofluid for SARS-CoV-2 detection during the early stages
of infection |
López-Martínez, B, Guzmán-Ortiz, et al |
Boletin medico del Hospital Infantil de Mexico |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The study aims to determine the optimal conditions for a saliva diagnostic test for COVID-19. Reverse transcription-polymerase
chain reaction was used to detect the viral genome in saliva samples kept at room temperature, in the fridge or frozen for 2 days. In addition, the influence of brushing teeth and feeding on the detection of the virus in saliva was addressed. Finally, the
efficiency of saliva in revealing the presence of the virus during the hospitalization period was determined in children. The viral genome was consistently detected regardless of the storage conditions of saliva samples. Brushing teeth and feeding did not
influence the sensitivity of the test. In hospitalized children, positive results were obtained only during the early days. These results support the idea of the use of saliva as an alternative specimen for diagnostic testing for COVID-19. The viral genome
is stable and endures perturbations in the oral cavity. |
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Protective Behavior in Course of the COVID-19 Outbreak—Survey Results From Germany |
Lüdecke, D, von dem Knesebeck, et al |
Frontiers in Public Health |
Public Health response| Interventions de santé publique |
This paper investigates different types and frequency of practicing protective behaviors, as well as socio-demographic
factors that are associated with such behavioral change. People with lower educational level were less likely to avoid gatherings, adapt their work situation, reduce personal contacts and meetings, or increase hand hygiene. Being female was associated with
higher odds of protective behavior for most outcomes. Exceptions were wearing face masks and adapting the own work situation. |
|
Lynn, R, Meisenberg, et al |
Mankind Quarterly |
Epidemiology| Épidémiologie |
Death rates from SARS-Cov2 in England and Wales are examined for the major ethnic minorities. Substantial differences
in death rate of different ethnicities were found that are not easily explained by demographic characteristics of these groups such as age and urban-versus-rural residence. This study looks at possible explanations for these disparities. Socio-economic factors
such as income and housing conditions are related to the observed differences in Covid-19 death rates, but average intelligence appears to be the best correlate. We also explore ethnic differences in the prevalence of some major chronic medical conditions
that are associated with Covid-19 mortality, and find that these appear insufficient as explanations for the different mortality rates. It is hypothesized that intelligence has both direct effects by making people more able to avoid infection, and indirect
effects through socio-economic conditions and through lifestyle factors that can lead to chronic health problems. |
|
|
Maddaloni, E, D'Onofrio, et al |
Diabetes research and clinical practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Aims: To evaluate whether subjects with diabetes hospitalized for Coronavirus disease-19 (Covid-19) represent a subgroup
of patients with high-risk clinical features compared to patients with diabetes without Covid-19. In this case-control study 79 patients with type 2 diabetes out of 354 adults hospitalized for Covid-19 and 158 controls with type 2 diabetes but without Covid-19,
matched for age and gender, were enrolled. Fully-adjusted multivariate logistic regression model showed that previous CVD history did not differ between patients with and without Covid-19. An increased prevalence of COPD and of CKD in Covid-19 patients with
type 2 diabetes is suggested. |
|
|
Mahalapbutr, P, Kongtaworn, et al |
Computational and Structural Biotechnology Journal |
Coronavirology| Coronavirologie |
In the present study, molecular recognition between the two natural nucleoside analogs (S-adenosyl-L-homocysteine (SAH)
and sinefungin (SFG)) and the SARS-CoV-2 nsp16/nsp10/m7GpppAC5 was studied using all-atom molecular dynamics simulations and free energy calculations based on MM/GBSA and WaterSwap approaches. The binding affinity and the number of hot-spot residues, atomic
contacts, and H-bond formations of SFG/nsp16 complex were distinctly higher than those of SAH/nsp16 system, consistent with the lower water accessibility at the enzyme active site. Notably, only SFG could electrostatically interact with the 2′-OH and N3 of
RNA's adenosine moiety, mimicking the methyl transfer reaction of S-adenosyl-L-methionine substrate. The atomistic binding mechanism obtained from this work paves the way for further optimizations and designs of more specific SARS-CoV-2 nsp16 inhibitors in
the fight against COVID-19. |
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Case Report: A Recovered SARS CoV-2 Patient Protected From Reinfection |
Mahallawi, W |
Frontiers in Medicine |
Clinical data| Données cliniques |
This is the first case report in Saudi Arabia on a patient who was diagnosed as COVID-19-positive; recovered; and after
successful recovery was protected against reinfection. |
|
Malhotra, V, Magoon, et al |
Journal of Investigative Medicine High Impact Case Reports |
Clinical data| Données cliniques |
As COVID-19 (coronavirus disease 2019) spreads across the world multiple therapeutic interventions have been tried
to reduce morbidity and mortality. We describe a case of collapsing focal sclerosing glomerulosclerosis (FSGS) and acute oxalate nephropathy in a patient treated with high-dose intravenous vitamin C for severe COVID-19 infection. Collapsing FSGS has been described
in patients with COVID-19 infection associated with APOL-1; however, this case had collapsing FSGS developing in low-risk heterozygous APOL-1 variant, and we postulate that the intensity of the COVID-19 cytokine storm overwhelmed the protective state of APOL-1
heterozygosity. This case illustrates the importance of assessing the risk and benefit of planned therapeutic interventions on a case-by-case basis especially when there are still so many unknowns in the management of COVID-19 infection. Strong consideration
should be given for performing a renal biopsy in patients who develop multifactorial acute kidney injury. © 2020 American Federation for Medical Research. |
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Anxiety Levels among Healthcare Professionals during
Covid-19 Pandemic: A Multifactorial Study |
Malik, Arif, Hafeez, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
The current study focuses on psychological stress level among doctors, estimated by calculating anxiety score. For
the assessment of anxiety levels, the GAD-7 scale was used. Chi-Square test and Odd ratios were calculated among the exposed and not exposed groups involved in the management of COVID-19 patients. Results revealed increased anxiety levels in the exposed group.
Besides, the availability of personal protective equipments and stress from the family to quit the job were the substantial contributing factors that increased anxiety. Based on the results, it is proposed that the concern administrative authorities should
consider these findings to facilitate medical healthcare professionals. |
|
Manenti, Alessandro, Molesti, et al |
bioRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The main aim of our study was to carry out SARS-CoV-2 wild type virus micro-neutralization (MN) assay in order to investigate
which optimal tissue culture infective dose 50 (TCID50) infective dose in use is the most adequate choice for implementation in terms of reproducibility, standardization possibilities and comparability of results. Therefore, we assessed the MN by using two
different viral infective doses: a standard dose of 100 TCID50/well and a lower dose of 25 TCID50/well. The results obtained, yielded by MN on using the lower infective dose (25 TCID50), were in line with those obtained with the standard infective dose; in
some cases, however, we detected a titre that was one or two dilution steps higher, which maintained all negative samples negative. This suggesting that the lower dose can potentially have a positive impact on the detection and estimation of neutralizing antibodies
present in a given sample, showing higher sensitivity but similar specificity and therefore, it would require a more accurate assessment and cross-laboratories standardisation especially when MN is employed as serological assay of choice for pre-clinical and
clinical studies. |
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Molecular mechanism of SARS-CoV-2 inactivation by temperature |
Marti, Didac, Torras, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, we unravel the basics of such inactivation mechanism over the SARS-CoV-2 spike glycoprotein by executing atomistic
molecular dynamics simulations. Both the closed down and open up states, which determine the accessibility to the receptor binding domain, were considered. Results suggest that the spike undergoes drastic changes in the topology of the hydrogen bond network
while salt bridges are mainly preserved. Reorganization in the hydrogen bonds structure produces conformational variations in the receptor binding subunit and explain the thermal inactivation of the virus. Conversely, the macrostructure of the spike is preserved
at high temperature because of the retained salt bridges. The proposed mechanism has important implications for engineering new approaches to inactivate the SARS-CoV-2 virus. |
|
McAuley, AJ, Kuiper, et al |
npj Vaccines |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
The ‘D614G’ mutation (Aspartate-to-Glycine change at position 614) of the SARS-CoV-2 spike protein has been speculated
to adversely affect the efficacy of most vaccines and countermeasures that target this glycoprotein, necessitating frequent vaccine matching. Virus neutralisation assays were performed using sera from ferrets which received two doses of the INO-4800 COVID-19
vaccine, and Australian virus isolates (VIC01, SA01 and VIC31) which either possess or lack this mutation but are otherwise comparable. Through this approach, supported by biomolecular modelling of this mutation and the commonly-associated P314L mutation in
the RNA-dependent RNA polymerase, we have shown that there is no experimental evidence to support this speculation. We additionally demonstrate that the putative elastase cleavage site introduced by the D614G mutation is unlikely to be accessible to proteases. |
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Medetalibeyoglu, A, Senkal, et al |
Journal of Nutrition, Health and Aging |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to describe clinical characteristics and early outcomes of the older Covid-19 patients hospitalized in our
center comparatively with the younger patients, and also to analyze the triage factors that were related to the in-hospital mortality of older adults. 362 hospitalized patients with laboratory-confirmed Covid-19 from March 11 to May 11, 2020 in Istanbul, Turkey
participated. The demographic information; associated comorbidities; presenting clinical, laboratory, radiological characteristics on admission and outcomes from the electronic medical records were analyzed comparatively between the younger (<65 years) and
older (≥65 years) adults. The median age was 56 years (interquartile range IQR], 46–67), and 224 (61.9%) were male. There were 104 (28.7%) patients ≥65 years of age. More than half of the patients (58%) had one or more chronic comorbidity. The three most common
presenting symptoms in the older patients were fatigue/myalgia (89.4%), dry cough (72.1%), and fever (63.5%). Cough and fever were significantly less prevalent in older adults compared to younger patients (p=0.001 and 0.008, respectively). Clinically severe
pneumonia was present in 31.5% of the study population being more common in older adults (49% vs. 24.4%) (p<0.001). The laboratory parameters that were significantly different between the older and younger adults were as follows: the older patients had significantly
higher CRP, D-dimer, TnT, pro-BNP, procalcitonin levels, higher prevalence of lymphopenia, neutrophilia, increased creatinine, and lower hemoglobin, ALT, albumin level (p<0.05). In the radiological evaluation, more than half of the patients (54.6%) had moderate-severe
pneumonia, which was more prevalent in older patients (66% vs. 50%) (p=0.006). The adverse outcomes were significantly more prevalent in older adults compared to the younger patients (ICU admission, 28.8% vs. 8.9%; mortality, 23.1% vs. 4.3%, p<0.001). Among
the triage evaluation parameters, the only factor associated with higher mortality was the presence of clinically severe pneumonia on admission (Odds Ratio=12.3, 95% confidence interval=2.7–55.5, p=0.001). |
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Impact of weather conditions on incidence and mortality of COVID-19 pandemic
in Africa |
Meo, SA, Abukhalaf, et al |
European review for medical and pharmacological sciences |
Epidemiology| Épidémiologie |
The present study aims to investigate the impact of weather conditions, heat and humidity on the incidence and mortality
of COVID-19 pandemic in various regions of Africa. The overall results revealed a significant inverse correlation between humidity and the number of cases (r= -0.192, p<0.001) and deaths (r= -0.213, p<0.001). Similarly, a significant inverse correlation was
found between temperature and the number of cases (r= -0.25, p<0.001) and deaths (r=-0.18, p<0.001). |
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Geographically varying relationships of COVID-19 mortality with different
factors in India |
Middya, Asif Iqbal, Roy, et al |
Research Square prepub |
Epidemiology| Épidémiologie |
In this study, ordinary least square (global) and geographically weighted regression (local) methods are employed to
explore the geographical relationships between COVID-19 deaths and different driving factors. It is also investigated whether geographical heterogeneity exists in the relationships. More specifically, in this paper, the geographical pattern of COVID-19 deaths
and its relationships with different potential driving factors in India are investigated and analysed. Here, better knowledge and insights into geographical targeting of intervention against the COVID-19 pandemic can be generated by investigating the heterogeneity
of spatial relationships. The results show that the local method (geographically weighted regression) generates better performance (R2 = 0:973) with smaller Akaike Information Criterion (AICc = -77:93) as compared to the global method (ordinary least square).
The GWR method also comes up with lower spatial autocorrelation (Moran’s I = -0.0436 and p < 0:01) in the residuals. It is found that more than 87.5% of local R2 values are larger than 0.60 and almost 60% of R2 values are within the range 0:80 - 0:97. |
|
Mills, RichardJ, Humphrey, et al |
bioRxiv |
Clinical data| Données cliniques Animal model | Modèle animal |
To identify mechanisms and discover cardio-protective therapeutics, we use a state-of-the-art pipeline combining human
cardiac organoids with high throughput phosphoproteomics and single nuclei RNA sequencing. We identify that cytokine-storm induced diastolic dysfunction can be caused by a cocktail of interferon gamma, interleukin 1β and poly(I:C) and also human serum from
COVID-19 patients. Bromodomain protein 4 (BRD4) is activated along with pathology driving fibrotic and induced nitric oxide synthase genes. BRD inhibitors fully recover function in hCO and completely prevent death in a cytokine-storm mouse model. BRD inhibition
decreases transcription of multiple genes, including fibrotic, induced nitric oxide synthase and ACE2, and reduces cardiac infection from SARS-CoV2. Thus, BRD inhibitors are promising candidates to prevent COVID-19 mediated cardiac damage. |
|
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Evaluation of PEEP and prone positioning in early COVID-19 ARDS |
Mittermaier, M, Pickerodt, et al |
EClinicalMedicine |
Clinical data| Données cliniques |
This study evaluated the impact of high positive end-expiratory pressure (PEEP) and prone positioning in early COVID-19
Acute Respiratory Distress Syndrome (ARDS). In nine patients the impact of prone positioning on oxygenation was investigated. Additionally, the effects of high PEEP and prone positioning on pulmonary opacities in serial chest x-rays were determined by applying
a semiquantitative scoring-system. This investigation is part of the prospective observational PA-COVID-19 study. Patients responded to initiation of invasive high PEEP ventilation with markedly improved oxygenation, which was accompanied by reduced pulmonary
opacities within 6 h of mechanical ventilation. Decremental PEEP trials confirmed the need for high PEEP (17.9 (SD ± 3.9) mbar) for optimal oxygenation, while driving pressures remained low. Prone positioning substantially increased oxygenation (p<0.01). |
|
Mondi, A, Cimini, et al |
Journal of medical virology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We reported clinical and viroimmunological data of all HIV-positive patients admitted to our center with COVID-19 from
March 1 to May 12, 2020. Overall, five patients were included: all were virologically-suppressed on antiretroviral therapy and CD4+ count was greater than 350 cell/mm3 in all but two patients. Although all patients had evidence of pneumonia on admission, only
one developed respiratory failure. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was never detected from nasopharyngeal swabs in two patients, whereas in the others, viral clearance occurred within a maximum of 43 days. Immunoglobulin G
production was elicited in all patients and neutralizing antibodies in all but one patient. Specific-T-cell response developed in all patients but was stronger in those with the more severe presentations. Similarly, the highest level of proinflammatory cytokines
was found in the only patient experiencing respiratory failure. Despite a mild presentation, patients with more pronounced immunosuppression showed high degrees of both cytokines production and immune activation. Our study did not find an increased risk and
severity of COVID-19 in PLWH. Adaptative cellular immune response to SARS-CoV-2 appeared to correlate to disease severity. The mild clinical picture showed in advanced HIV patients, despite a significant T-cell activation and inflammatory profile, suggests
a potential role of HIV-driven immunological dysregulation in avoiding immune-pathogenetic processes. |
|
|
Moore, JL, Ganapathiraju, et al |
American Journal of Case Reports |
Clinical data| Données cliniques |
This is a case report of an immunocompromised patient with a history of non-Hodgkin lymphoma and persistent severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who was seronegative and successfully treated with convalescent plasma. |
|
|
Moosa, IA, Khatatbeh, et al |
Applied Economics |
Epidemiology| Épidémiologie |
An attempt is made to identify the factors that can explain inter-country differences in the severity of Covid-19,
measured by the infection and case fatality rates. To circumvent the problem of the sensitivity of the results with respect to the selected set of explanatory variables, extreme bounds analysis (EBA) is applied to a cross-sectional sample of 154 countries.
The results show that the infection and fatality rates depend on different factors, except for the number of tests, which is a robust determinant of both. An interesting result is that the infection rate depends on urban population rather than the overall
population density. Another interesting result is that the fatality rate depends on the age structure of the population and population density but not on the percentage of urban population. |
|
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Triple therapy with hydroxychloroquine, azithromycin, and ciclesonide for COVID-19
pneumonia |
Mori, N, Katayama, et al |
Journal of Microbiology, Immunology and Infection |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We report the effectiveness and adverse effects of triple therapy with hydroxychloroquine, azithromycin, and ciclesonide
in patients with COVID-19 pneumonia. The clinical condition of the patients improved within 5 days in response to the therapy. |
|
The effect of temperature and humidity on the stability
of SARS-CoV-2 and other enveloped viruses |
Morris, DylanH, Yinda, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, we characterise the stability of SARS-CoV-2 on an inert surface at a variety of temperature and humidity conditions,
and introduce a mechanistic model that enables accurate prediction of virus stability in unobserved conditions. We find that SARS-CoV-2 survives better at low temperatures and extreme relative humidities; median estimated virus half-life was more than 24 hours
at 10 °C and 40 % RH, but less than an hour and a half at 27 °C and 65 % RH. Our results highlight scenarios of particular transmission risk, and provide a mechanistic explanation for observed superspreading events in cool indoor environments such as food
processing plants. Moreover, our model predicts observations from other human coronaviruses and other studies of SARS-CoV-2, suggesting the existence of shared mechanisms that determine environmental stability across a number of enveloped viruses. |
|
Ms, Narassima, Jammy, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We present an ABM approach with a synthetic population from Rangareddy district, Telangana state, India, to examine
the patterns and trends of the COVID-19 in terms of infected, admitted, critical cases requiring intensive care and/ or ventilator support, mortality and recovery. The model is developed based on data pertaining to a local area, i.e. district, as this prove
to be much helpful for policymaking compared to models estimating nation-wide disease projections. The parameters for the ABM model were defined and model run for a period of 365 days for three different non-pharmaceutical intervention (NPI) scenarios, namely;
no lockdown, 50% lockdown and 75% lockdown scenarios. AnyLogic platform was used for the ABM simulations. Results revealed that the peak values and slope of the curve declined as NPI became more stringent. The results could provide a platform for researchers
and modelers to explore using ABM approach for COVID-19 projections with inclusion of interventions and health system preparedness. |
|
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Predictors of severe symptomatic laboratory-confirmed
SARS-COV-2 reinfection |
Murillo-Zamora, Efren, Mendoza-Cano, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective: To evaluate factors predicting severe symptomatic laboratory-confirmed SARS-COV-2 reinfection. Method: We
conducted a nationwide retrospective cohort study in Mexico and data from 258 reinfection cases were analyzed. We used risk ratios (RR) and 95% confidence intervals (CI) to evaluate predictors of severe (dyspnea requiring hospital admission) secondary SARS-COV-2
infection. Results: The risk of severe disease was 14.7% and the observed overall fatality rate was 4.3%. Patients with more serious primary disease were more likely to develop severe symptoms during reinfection. In multiple analysis, factors associated with
an increased risk of severe symptomatic SARS-COV-2 reinfection were increasing age, comorbidities (namely obesity, asthma, type 2 diabetes mellitus) and previous severe laboratory-confirmed COVID-19. |
|
Anticoagulation, Bleeding, Mortality, and Pathology in Hospitalized Patients With
COVID-19 |
Nadkarni, GN, Lala, et al |
Journal of the American College of Cardiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The purpose of this study was to examine association of anticoagulation (AC) with in-hospital outcomes and describe
thromboembolic findings on autopsies. Among 4,389 patients, median age was 65 years with 44% women. Compared with no AC (n = 1,530; 34.9%), therapeutic AC (n = 900; 20.5%) and prophylactic AC (n = 1,959; 44.6%) were associated with lower in-hospital mortality
(adjusted hazard ratio aHR]: 0.53; 95% confidence interval CI]: 0.45 to 0.62 and a HR: 0.50; 95% CI: 0.45 to 0.57, respectively), and intubation (aHR: 0.69; 95% CI: 0.51 to 0.94 and a HR: 0.72; 95% CI: 0.58 to 0.89, respectively). When initiated ≤48 h from
admission, there was no statistically significant difference between therapeutic (n = 766) versus prophylactic AC (n = 1,860) (aHR: 0.86; 95% CI: 0.73 to 1.02; p = 0.08). Overall, 89 patients (2%) had major bleeding adjudicated by clinician review, with 27
of 900 (3.0%) on therapeutic, 33 of 1,959 (1.7%) on prophylactic, and 29 of 1,530 (1.9%) on no AC. Of 26 autopsies, 11 (42%) had thromboembolic disease not clinically suspected and 3 of 11 (27%) were on therapeutic AC. |
|
Naeem, K, Riaz, et al |
International Journal of Biomathematics |
Therapeutics| Thérapeutique |
The aim behind this article is to discover the preventive measure that should be taken to cope with Covid-19. We study
the prime notions of novel sort of topology accredited Pythagorean m-polar fuzzy topology along with its prime attributes. We slightly amend the well-Acknowledged multi-criteria decision analysis tool TOPSIS (Technique for Order of Preference by Similarity
to Ideal Solution) to befit the proposed multi-criteria group decision making (MCGDM) problem of exploring the most effective method for curing from COVID-19 employing the proposed model. |
|
|
Nagaj, R, Korpysa, et al |
Energies |
Economics | Économie |
The main objective of the paper is to determine the impact of the COVID-19 pandemic on the level of energy poverty
in Poland. the present pandemic contributed to the aggravation of financial difficulties in Polish households with regard to financing expenditure on energy carriers. It was found that COVID-19 had a negative impact on the average disposable income of Polish
households, which, with the increase in prices and expenditure on energy carriers, led to an increase in the proportion of disposable income spent on energy carriers. |
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Θ-SEIHRD mathematical model of Covid19-stability analysis using fast-slow decomposition |
Nave, O, Hartuv, et al |
PeerJ |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this study, we apply the singular perturbed vector field (SPVF) method to the COVID-19 mathematical model of to
expose the hierarchy of the model. This decomposition enables us to rewrite the model in new coordinates in the form of fast and slow subsystems and, hence, to investigate only the fast subsystem with different asymptotic methods. In addition, this decomposition
enables us to investigate the stability analysis of the model, which is important in case of COVID-19. We found the stable equilibrium points of the mathematical model and compared the results of the model with those reported by the Chinese authorities and
found a fit of approximately 96 percent. |
|
Neve, Dishita, Patel, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In the current analysis, COVID-19 modeling is done for the Indian subcontinent based on the data collected for the
total cases confirmed, daily recovered, daily deaths, total recovered and total deaths. The data is treated with total confirmed cases as the target variable and rest as feature variables. It is observed that Support vector regressions yields accurate results
followed by Polynomial regression. Random forest regression results in overfitting followed by poor Bayesian regression due to highly correlated feature variables. Further, in order to examine the effect of neighbouring countries, Pearson correlation matrix
is computed to identify geographic cause and effect. The rate of Total Confirmed Cases and Recovered was increasing at a slow pace but after April 31, 2020 there was an exponential growth in both Total Confirmed Cases and Recovered Cases. |
|
|
Newman, N, Gilman, et al |
International journal of medical informatics |
Healthcare Response | Réponse des soins de santé |
Authors present a simple, reproducible, and highly-customizable manual-entry tool to track ICU patients using new HIPAA-compliant
Google Big Query technology for parsing large datasets. The functional tests performed demonstrate use of the tool. |
|
|
Odagaki, Takashi |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Exploiting the SIQR model for COVID-19, I show that the wavy infection curve in Japan is the result of fluctuation
of policy on isolation measure imposed by the government and obeyed by citizens, Assuming the infection coefficient be a 2-valued function of the number of infected individuals, I show that when the removal rate of infected individuals is between these two
values, the wavy infection curve is self-organized. On the basis of the infection curve, I classify the outbreak of COVID-19 in each country into five types and show that these differences can be related to the relative magnitude of the transmission coefficient
and the quarantine rate of infected individuals. |
|
|
Automatic detection of COVID-19 infection using chest X-ray images through transfer
learning |
Ohata, EF, Bezerra, et al |
IEEE/CAA Journal of Automatica Sinica |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this work, we propose an automatic detection method for COVID-19 infection based on chest X-ray images. The datasets
constructed for this study are composed of 194 X-ray images of patients diagnosed with coronavirus and 194 X-ray images of healthy patients. Since few images of patients with COVID-19 are publicly available, we apply the concept of transfer learning for this
task. We use different architectures of convolutional neural networks (CNNs) trained on ImageNet, and adapt them to behave as feature extractors for the X-ray images. Then, the CNNs are combined with consolidated machine learning methods, such as k-Nearest
Neighbor, Bayes, Random Forest, multilayer perceptron (MLP) , and support vector machine (SVM) . The results show that, for one of the datasets, the extractor-classifier pair with the best performance is the MobileNet architecture with the SVM classifier using
a linear kernel, and for the other dataset, the best pair is DenseNet201 with MLP. Thus, the proposed approach demonstrates efficiency in detecting COVID-19 in X-ray images. |
|
Okoh, AK, Bishburg, et al |
Journal of medical virology |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We sought to evaluate the effect of tocilizumab (TCB), a recombinant humanized monoclonal antibody against soluble
interleukin-6 receptors, in patients hospitalized for COVID-19. We included all patients with laboratory-confirmed COVID-19 who had completed hospitalization between March 10, 2020 and April 10, 2020 with follow-up through April 20, 2020. Patients who received
TCB in addition to standard of care within 48 h of admission were matched in a 1:2 fashion to a similar cohort who received standard of care alone. Out of 77 patients who received TCB in addition to standard of care, 34% (n = 26) received TCB within 48 h of
admission. One-to-two propensity matching identified 20 versus 40 patients in the TCB and no-TCB treatment arms. In the TCB group, an improvement in oxygenation was observed in 80% (n = 16) of the patients by 7 days post TCB administration. After matching,
there was no difference in clinical outcomes between TCB and no-TCB patients. In-hospital death: 10% versus 8%; p =.823, septic shock: 10% versus 11%, p =.912, AKI requiring hemodialysis (10% vs. 13%; p =.734). Early treatment with TCB in patients admitted
for COVID-19 led to an improvement in their oxygen status during hospitalization. This change however did not translate into improved survival when compared to a matched cohort with a similar clinical profile. |
|
|
Olaechea-Lazaro, Sonia, Garcia-Santisteban, et al |
medRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we present shinyCurves, a shiny web application created to analyse multisource qPCR amplification data from independent
multi-plate format. Furthermore, our automated system allows the classification of the results as well as the plot of both amplification and melting curves. when attempting to detect the presence of circulating viral nucleic acids, the application allows the
user to decide the settings that will classify samples into three categories (“Positive”, “Negative” or “Undetermined”). Besides, shinyCurves offers the possibility to plot both amplification and melting curves, providing additional quality control on the
specificity of the amplification. |
|
|
Olickal, JJ, Chinnakali, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
This cross-sectional study aims to assess the effect and urban-rural differences of COVID19 pandemic on diabetes care
in Southern India. A total of 350 persons with diabetes (PWDs) were interviewed. Majority were male (78%) and from rural areas (79%). One fourth (24%) met any physician for diabetes care at least once during lockdown. PWDs from rural areas mainly consulted
a physician in a private clinic (55%) compared to urban areas (26%). Two third (65%) availed medications from private medical shops. Almost half (46%) got their blood sugar tested during and majority of them (81%) reported unsatisfactory glycemic control.
Only few (5%) was aware and three utilized telemedicine services. Almost all (99%) spent money (US $ 8.3) for diabetes care. One third (33%) had moderate or high psychological distress. Conclusions: Majority of PWDs did not consult a physician during lockdown.
Cost of care was high. Measures to improve utilisation of telemedicine services and peripheral health facilities are needed. |
|
|
Effects of Covid-19 confinement on the mental health of children and adolescents
in Spain |
Ordóñez-Camblor, Nuria, Pizarro-Ruiz, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
he aim of the present study was to explore the consequences of confinement on the mental health of Spanish children
and teenagers, at the time when minors had been locked down in their homes between 8 and 10 days. The sample was composed of 590 confined Spanish children and teenagers between 8 and 18 years old. The scales of Depression, Self-esteem, Anxiety, Problems with
Emotional Regulation, Rage Control Problems, Integration and Social Competence, Somatic Complaints, Rebellious Behaviour, as well as Awareness of the Problems of the Assessment System for Children and Adolescents (SENA) were used. The results revealed that,
during confinement, children and adolescents showed emotional and behavioural alterations. |
|
QReLU and m-QReLU: Two novel quantum activation functions to aid medical diagnostics |
Parisi, L, N |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The two novel AFs were evaluated in a two-layered CNN against nine ReLU-based AFs on seven benchmark datasets, including
images of spiral drawings taken via graphic tablets from patients with Parkinson Disease and healthy subjects, and point-of-care ultrasound images on the lungs of patients with COVID-19, those with pneumonia and healthy controls. Despite a higher computational
cost, results indicated an overall higher classification accuracy, precision, recall and F1-score brought about by either quantum AFs on five of the seven bench-mark datasets, thus demonstrating its potential to be the new benchmark or gold standard AF in
CNNs and aid image classification tasks involved in critical applications, such as medical diagnoses of COVID-19 and PD. |
|
Parker, A, Koegelenberg, et al |
South African Medical Journal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to describe the prevalence, clinical features, comorbidities and outcome of an early cohort of HIV-positive
and HIV-negative patients admitted with COVID-19. Of 116 patients (mean age 48 years, 61% female) admitted, 24 were HIV-positive (21%). The most common symptoms reported were cough (n=88; 73%), shortness of breath (n=78; 69%), fever (n=67; 59%), myalgia (n=29;
25%) and chest pain (n=22; 20%). The most common comorbidities were hypertension (n=46; 41%), diabetes mellitus (n=43; 38%), obesity (n=32; 28%) and HIV (n=24; 21%). Mortality was associated with older age (mean (standard deviation) 55 (12) years v. 46 (14)
years; p<0.01); the presence of hypertension or hypertension along with diabetes and/or obesity; lower partial pressure of arterial oxygen to fraction of inspired oxygen ratio; and higher urea level, white cell count, neutrophil count, and C-reactive protein,
lactate dehydrogenase and ferritin levels, and high neutrophil to lymphocyte ratio. The overall survival rate for all hospital admissions was 86/116 (73%). In this early cohort, survival was similar in patients with HIV (n=18; 75%) compared with those without
HIV (n=67; 75%) (p=1). Of the 74 patients admitted to the wards, 63 (85%) survived, whereas 22 of 42 (52%) admitted to the intensive care unit survived. |
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|
Phylogenetic analysis of SARS-CoV-2 in the first few months since its
emergence |
Pereson, MJ, Mojsiejczuk, et al |
Journal of medical virology |
Coronavirology| Coronavirologie |
The aim of this study was to perform a comprehensive evolutionary analysis to describe the human outbreak and the evolutionary
rate of different genomic regions of SARS-CoV-2. The molecular evolution in nine genomic regions of SARS-CoV-2 was analyzed using three different approaches: phylogenetic signal assessment, emergence of amino acid substitutions, and Bayesian evolutionary rate
estimation in eight successive fortnights since the virus emergence. All observed phylogenetic signals were very low and tree topologies were in agreement with those signals. However, after 4 months of evolution, it was possible to identify regions revealing
an incipient viral lineage formation, despite the low phylogenetic signal since fortnight 3. Finally, the SARS-CoV-2 evolutionary rate for regions nsp3 and S, the ones presenting greater variability, was estimated as 1.37 × 10−3 and 2.19 × 10−3 substitution/site/year,
respectively. In conclusion, results from this study about the variable diversity of crucial viral regions and determination of the evolutionary rate are consequently decisive to understand essential features of viral emergence. In turn, findings may allow
the first-time characterization of the evolutionary rate of S protein, crucial for vaccine development. |
|
Petersen, I, Phillips, et al |
Clinical Epidemiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We evaluated the value of COVID-19 symptoms as a marker for SARS-CoV-2 infection from a representative English survey.
We used data from the Office for National Statistics Coronavirus (COVID-19) Infection Survey pilot study. We estimated sensitivity, specificity, the proportion of asymptomatic cases (1 – sensitivity), positive predictive value (PPV) and negative predictive
value (NPV) of COVID-19 symptoms as a marker of infection using results of the SARS-CoV-2 test as the “gold standard”. COVID-19 symptoms are poor markers of SARS-CoV-2. Thus, 76.5% of this random sample who tested positive reported no symptoms, and 86.1% reported
none of those specific to COVID-19. |
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Meteorology-normalized impact of the COVID-19 lockdown upon NO2 pollution in Spain |
Petetin, H, Bowdalo, et al |
Atmospheric Chemistry and Physics |
Public health interventions*| Interventions de santé publique |
Our study uses machine-learning (ML) models fed by meteorological data along with other time features to estimate the
"business-as-usual"NO2 mixing ratios that would have been observed in the absence of the lockdown. During the period of study, from the enforcement of the state of alarm in Spain on 14 March to 23 April, we found the lockdown measures to be responsible for
a 50% reduction in NO2 levels on average over all provinces and islands. The lockdown in Spain has gone through several phases with different levels of severity with respect to mobility restrictions. As expected, the meteorology-normalized change in NO2 was
found to be stronger during phase II (the most stringent phase) and phase III of the lockdown than during phase I. In the largest agglomerations, where both urban background and traffic stations were available, a stronger meteorology-normalized NO2 change
is highlighted at traffic stations compared with urban background sites. |
|
Pirouz, B, Nejad, et al |
Information (Switzerland) |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
This research aims to study the possible correlation between the numbers of swab tests and the trend of confirmed cases
of infection, while paying particular attention to the sickness level. The study is carried out in relation to the Italian case, but the result is of more general importance, particularly for countries with limited ICU (intensive care units) availability.
The statistical analysis showed that, by increasing the number of tests, the trend of home isolation cases was positive. However, the trend of mild cases admitted to hospitals, intensive case cases, and daily deaths were all negative. The result of the statistical
analysis provided the basis for an AI study by ANN. In addition, the results were validated using a multivariate linear regression (MLR) approach. Our main result was to identify a significant statistical effect of a reduction of pressure on the health care
system due to an increase in tests. The relevance of this result is not confined to the COVID-19 outbreak, because the high demand of hospitalizations and ICU treatments due to this pandemic has an indirect effect on the possibility of guaranteeing an adequate
treatment for other high-fatality diseases, such as, e.g., cardiological and oncological ones. Our results show that swab testing may play a significant role in decreasing stress on the health system. Therefore, this case study is relevant, in particular,
for plans to control the pandemic in countries with a limited capacity for admissions to ICU units. |
|
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The economic impacts of COVID-19 in Brazil based on an interregional CGE approach |
Porsse, AA, de Souza, et al |
Regional Science Policy and Practice |
Economics | Économie |
This study projects the economic impacts of COVID-19 outbreak on the Brazilian economy using a dynamic interregional
computable general equilibrium model. We considered two scenarios. The first scenario has two channels of transmission over the economic system: a negative shock of labour supply due to the rates of morbidity and mortality caused by the pandemic, and a temporary
shutdown of nonessential economic activities. The second scenario adds to the first the effects of the government fiscal package adopted to counteract the effects of COVID-19 on the economy. Furthermore, in both scenarios, a sensitive analysis related to the
temporality of the shutdown is considered by assuming 3 and 6 months of shutdown. The results indicate a reduction of 3.78% in the national GDP growth rate in Scenario 1 and a reduction of 0.48% in Scenario 2, in 2020, with 3 months of shutdown. With 6 months,
the reduction would be greater, 10.90% and 7.64% in Scenarios 1 and 2, respectively. Thus, the government fiscal stimulus considered in this study partially mitigates the reduction in GDP projected under the COVID-19 outbreak. |
|
Posarelli, C, Maglionico, et al |
PLoS ONE |
Healthcare Response | Réponse des soins de santé |
The purpose of this study is to analyze how the pandemic has affected the patient’s accesses to the Ophthalmological
Emergency Department of a tertiary referral center in central-northern Italy, during the lockdown period. A significant reduction of visits during the lockdown has been observed, compared with those of pre-lockdown period (reduction of 65.4%) and with those
of the same period of 2019 (reduction of 74.3%). Particularly, during the lockdown, minor and not urgency visits decreased whereas the undeferrable urgency ones increased. |
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“Cronache Lucane”: Adaptability of the basilicata in the times of Covid-19 |
Postiglione, L |
Documenti Geografici |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
The Resilience Alliance has developed a methodological scheme for assessing disturbances in a socio-urban system: Resilience
Thinking. This model analyzes the characteristics of the perturbing system in relation to the perturbed one. This work, through Adaptability and Transformability, pillars of Resilience, intends to evaluate the performance of these two variables in the geographical
context of Basilicata, to add an additional piece to risk studies in the face of emergencies of this magnitude. By means of local sources of information and disclosure, the aim of this paper is to evaluate the impact of Covid-19 on Basilicata region and the
effectiveness of the active mitigation policies. © Universita degli Studi di Roma Tor Vergata. |
|
Poyiadji, N, Klochko, et al |
Academic Radiology |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to assess the differential impact the pandemic had on radiology resident imaging volumes
by training year and imaging modality. All signed radiology resident reports were curated during defined prepandemic and intrapandemic time periods. Imaging case volumes were analyzed on a mean per resident basis to quantify absolute and percent change by
training level. Change in total volume by imaging modality was also assessed. The number of resident workdays assigned outside the normal reading room was also calculated. Overall percent decline in resident imaging interpretation volume from the prepandemic
to intrapandemic time period was 62.8%. R1s and R2s had the greatest decline at 87.3% and 64.3%, respectively. Mammography, MRI and nuclear medicine had the greatest decline in resident interpretation volume at 92.0%, 73.2%, and 73.0%, respectively. During
the intrapandemic time period, a total of 478 resident days (mean of 14.5 days per resident) were reassigned outside of the radiology reading room. The decrease in case interpretation, as well as in-person teaching has profound implications for resident education. |
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SARS-CoV-2 S protein ACE2 interaction reveals novel
allosteric targets |
Raghuvamsi, Palur, Tulsian, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, we have mapped the S:ACE2 interface and uncovered long-range allosteric propagation of ACE2 binding to sites
critical for viral host entry. Unexpectedly, ACE2 binding enhances dynamics at a distal S1/S2 cleavage site and flanking protease docking site ~27 Å away while dampening dynamics of the stalk hinge (central helix and heptad repeat) regions ~ 130 Å away. This
highlights that the stalk and proteolysis sites of the S protein are dynamic hotspots in the pre-fusion state. Our findings provide a mechanistic basis for S:ACE2 complex formation, critical for proteolytic processing and viral-host membrane fusion and highlight
protease docking sites flanking the S1/S2 cleavage site, fusion peptide and heptad repeat 1 (HR1) as allosterically exposed cryptic hotspots for potential therapeutic development. |
|
Rahman, MS, Islam, et al |
Transboundary and Emerging Diseases |
Coronavirology| Coronavirologie |
In order to explore mutations and deletions in the spike (S) protein — the most-discussed protein of SARS-CoV-2 — we
comprehensively analyzed 35,750 complete S protein-coding sequences through a custom Python-based pipeline. This GISAID-collected dataset of until 24 June 2020 covered six continents and five major climate zones. We identified 27,801 (77.77% sequences) mutated
strains compared to reference Wuhan-Hu-1 wherein 84.40% of these strains mutated by only a single amino acid (aa). An outlier strain (EPI_ISL_463893) from Bosnia and Herzegovina possessed six aa substitutions. We also identified 11 residues with high aa mutation
frequency, and each contains four types of aa variations. The infamous D614G variant has spread worldwide with ever-rising dominance and across regions with different climatic conditions alongside L5F and D936Y mutants, which have been documented throughout
all regions and climate zones, respectively. We also found 988 unique aa substitutions spanned across 660 residues, which differed significantly among different continents (p =.003) and climatic zones (p =.021) as inferred with the Kruskal–Wallis test. Besides,
17 in-frame deletions at four sites adjacent to receptor-binding-domain were determined that may have a possible impact on attenuation. This study provides a fast and accurate pipeline for identifying mutations and deletions from the large dataset for coding
and also non-coding sequences as evidenced by the representative analysis on existing S protein data. |
|
|
Raman, Betty, Cassar, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Fifty-eight COVID-19 patients post-hospital discharge and 30 comorbidity-matched controls were prospectively enrolled
for multiorgan (brain, lungs, heart, liver and kidneys) magnetic resonance imaging (MRI), spirometry, six-minute walk test, cardiopulmonary exercise test (CPET), quality of life, cognitive and mental health assessments. Findings At 2-3 months from disease-onset,
64% of patients experienced persistent breathlessness and 55% complained of significant fatigue. On MRI, tissue signal abnormalities were seen in the lungs (60%), heart (26%), liver (10%) and kidneys (29%) of patients. COVID-19 patients also exhibited tissue
changes in the thalamus, posterior thalamic radiations and sagittal stratum on brain MRI and demonstrated impaired cognitive performance, specifically in the executive and visuospatial domain relative to controls. Exercise tolerance (maximal oxygen consumption
and ventilatory efficiency on CPET) and six-minute walk distance were significantly reduced in patients. The extent of extra-pulmonary MRI abnormalities and exercise tolerance correlated with serum markers of ongoing inflammation and severity of acute illness.
Patients were more likely to report symptoms of moderate to severe anxiety and depression and significant impairment in all domains of quality of life compared to controls. |
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TREATMENT PROFILES AND CLINICAL OUTCOMES OF COVID-19
PATIENTS AT PRIVATE HOSPITAL IN JAKARTA |
Ramatillah, Diana Laila, Isnaini, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
Objectives: To find out the effective treatment as an antiviral agent for COVID-19, to determine the correlation between
sociodemography with clinical outcomes and duration of treatment, and to determine the relationship between comorbidities with clinical outcomes and duration of treatment for COVID-19 patients. Methods: A prospective cohort study was conducted in this study.
This study included only confirmed COVID-19 patients who were admitted to the hospital during April-May 2020. Results: The survival analysis for COVID-19 patients using the Kaplan Meier method showed that patients receiving Oseltamivir + Hydroxychloroquine
had an average survival rate of about 83% after undergoing treatment for about ten days. Gender and age did not have a significant correlation with the duration of treatment for COVID-19 patients. Gender and age also did not have a significant correlation
with clinical outcome of COVID-19 patients. Comorbidities showed a significant correlation with duration of treatment and clinical outcome of COVID-19 patients. |
|
Melatonin is significantly associated with survival
of intubated COVID-19 patients |
Ramlall, Vijendra, Zucker, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
Methods In this retrospective study, we used survival analysis to determine whether or not mortality following intubation
was associated with hormone exposure in patients treated at New York Presbyterian/ Columbia University Irving Medical Center. Here, we report the overall hazards ratio for each hormone for exposure before and after intubation for intubated and mechanically
ventilated patients. Results we identified 948 intubation periods across 791 patients who were diagnosed with COVID-19 or infected with SARS-CoV2 and 3,497 intubation periods across 2,981 patients who were not. Melatonin exposure after intubation is significantly
associated with a positive outcome in COVID-19 and non-COVID-19 patients. Additionally, melatonin exposure after intubation is significantly associated with a positive outcome in COVID-19 patients requiring mechanical ventilation. |
|
Ran, J, Zhao, et al |
Frontiers in Medicine |
Epidemiology| Épidémiologie Transmission |
We conducted univariable and multivariable linear regression, using R0 as the response and air pollutant as the factor,
adjusted by temperature and relative humidity. In this large-scale ecological study, we find no significant association between the three gaseous air pollutants (NO2, SO2, and CO) and the initial transmissibility of COVID-19 in Chinese cities. |
|
|
Reigal, RE, Pastrana-Brincones, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
MenPas is a psychosocial assessment platform1 developed by the University of Malaga in 2008. There has been a significant
increase in data traffic during the period of confinement by COVID-19. The main objective was to determine if the COVID-19 Pandemic has changed the pattern of Menpas users. The analyses have shown changes in cluster formation between 2019 and 2020 based on
the variables gender, age, marital status or physical practice. |
|
|
Richards-Belle, A, Orzechowska, et al |
Journal of the Intensive Care Society |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We describe 60-day outcomes for patients critically ill with confirmed COVID-19 and explore the potential bias in the
weekly reported data by ICNARC. First 200 consecutive patients with confirmed COVID-19, admitted for critical care in England, Wales and Northern Ireland, followed-up for a minimum of 60 days from admission. Mean age was 62.6 years, 70.5% were male, 52.0%
were white, 39.2% obese and 9.0% had serious comorbidities. Median APACHE II score was 16 (IQR 12, 19). After 60 days, 83 (41.5%) patients had been discharged from hospital, 15 (7.5%) had been discharged from critical care but remained in hospital, 1 (0.5%)
was still receiving critical care, 90 (45.0%) had died while receiving critical care and 11 (5.5%) had died in hospital after discharge from critical care. Median duration of critical care was 14.0 days (IQR 6.1, 23.0) for survivors and 10.0 days (IQR 5.0,
16.0) for non-survivors of critical care. Overall, 158 (79.0%) patients received advanced respiratory support for a median of 13 (IQR 8, 20) calendar days. Compared with weekly reports during the pandemic, critical care mortality started higher than but then
decreased below that of the first 200 consecutive patients. Duration of critical care, for both survivors and non-survivors increased over time; however, both were still lower than those for the first 200 consecutive patients. Receipt and duration of organ
support increased to values similar to those for the first 200 consecutive patients. |
|
|
Awareness on the treatment and vaccines for covid-19 infection among dental students-a
survey |
Rieshy, V, Gayathri, et al |
International Journal of Pharmaceutical Research |
Healthcare Response | Réponse des soins de santé |
The main aim of this study is to assess the awareness on the treatment and vaccines for COVID-19 infection among dental
students. A self-designed survey study was conducted among 100 dental students. From the result, it was evident that 85% of the survey population follow the practices to prevent COVID 19 infection, they were also aware of treatment given and the unavailability
of vaccines for the infection. It was also found that both male and female students were equally aware of the existing treatment and unavailability of vaccine for COVID 19.(p-value>0.05). |
|
Rivieccio, Bruno Alessandro, Micheletti, et al |
medRxiv |
Public Health response| Interventions de santé publique |
From a public health point of view, therefore, it is fundamental to provide healthcare services with tools that can
reveal a possible new epidemic burden with a certain time anticipation, which is the main aim of the present study. in order to find potential predictors of a possible second epidemic wave, we analyzed data both from Twitter and from emergency services comparing
them to the daily infected time series at a regional level. Since our principal goal is to forecast a possible new ascending phase of the epidemic, we performed a wavelet analysis in the time-frequency plane, to finely discriminate over time the anticipation
capability of the considered potential predictors. In addition, a cross-correlation analysis has been performed to find a synthetic indicator of the time delay between the predictor and the infected time series. Our results show that Twitter data are more
related to social and political dynamics, while the emergency calls trends can be further evaluated as a powerful tool to potentially forecast a new burden. Since we analyzed aggregated regional data, and taking into account also the huge geographical heterogeneity
of the epidemic spread, a future perspective would be to conduct the same analysis on a more local basis. |
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|
Rizo-Téllez, SA, Méndez-García, et al |
Microorganisms |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We examined the efficacy of the lymphocyte-to-neutrophil ratio (LNR) and neutrophil-to-monocyte ratio (NMR) as predictors
of in-hospital death at admission in patients with severe Covid-19. A total of 54 Mexican adult patients with Covid-19 that met hospitalization criteria were retrospectively enrolled. A total of 20 patients with severe Covid-19 died, and 75% of them were
men older than 62.90 ± 14.18 years on average. Type 2 diabetes, hypertension, and coronary heart disease were more prevalent in non-survivors. As compared to survivors, LNR was significantly fourfold decreased while NMR was twofold increased. LNR ≤ 0.088 predicted
in-hospital mortality with a sensitivity of 85.00% and a specificity of 74.19%. NMR ≥ 17.75 was a better independent risk factor for mortality with a sensitivity of 89.47% and a specificity of 80.00%. |
|
|
Rochman, NashD, Wolf, et al |
bioRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
We show that the ongoing evolution of SARS-CoV-2 over the course of the pandemic is characterized primarily by purifying
selection. However, a small set of sites, including the extensively studied spike 6143, harbor mutations which recurred on multiple, independent occasions, indicative of positive selection. These mutations form a strongly connected network of apparent epistatic
interactions. The phylogenetic tree of SARS-CoV-2 consists of 7 major clades which show distinct global and temporal dynamics. Periods of regional diversification of SARS-CoV-2 are short and, despite dramatically reduced travel4, globalization of the virus
is apparent. |
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|
Romero-López, JP, Carnalla-Cortés, et al |
Journal of medical virology |
Coronavirology| Coronavirologie Immunology | Immunologie |
SARS-CoV-2 infection is causing a pandemic disease that is reflected in challenging public health problems worldwide.
Human leukocyte antigen (HLA)-based epitope prediction and its association with disease outcomes provide an important base for treatment design. A bioinformatic prediction of T cell epitopes and their restricted HLA Class I and II alleles was performed to
obtain immunogenic epitopes and HLA alleles from the spike protein of the severe acute respiratory syndrome coronavirus 2 virus. Also, a correlation with the predicted fatality rate of hospitalized patients in 28 states of Mexico was done. Here, we describe
a set of 10 highly immunogenic epitopes, together with different HLA alleles that can efficiently present these epitopes to T cells. Most of these epitopes are located within the S1 subunit of the spike protein, suggesting that this area is highly immunogenic.
A statistical negative correlation was found between the frequency of HLA-DRB1*01 and the fatality rate in hospitalized patients in Mexico. © 2020 Wiley Periodicals LLC |
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Multivalency transforms SARS-CoV-2 antibodies into
broad and ultrapotent neutralizers |
Rujas, Edurne, Kucharska, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, we used the human apoferritin protomer as a modular subunit to drive oligomerization of antibody fragments and
transform antibodies targeting SARS-CoV-2 into exceptionally potent neutralizers. Using this platform, half-maximal inhibitory concentration (IC50) values as low as 9E-14 M were achieved as a result of up to 10,000-fold potency enhancements. Combination of
three different antibody specificities and the fragment crystallizable (Fc) domain on a single multivalent molecule conferred the ability to overcome viral sequence variability together with outstanding potency and Ig-like in vivo bioavailability. This MULTi-specific,
multi-Affinity antiBODY (Multabody; or MB) platform contributes a new class of medical countermeasures against COVID-19 and an efficient approach to rapidly deploy potent and broadly-acting therapeutics against infectious diseases of global health importance. |
|
Samah, IHA, Rashid, et al |
International Journal of Energy Economics and Policy |
Economics | Économie |
This study aims to observe empirically the effect of healthcare expenditure and heath sectors growth on CO2 during
Covid 19 outbreak in Malaysia. |
|
|
Nosocomial SARS-CoV-2 infection in urology departments: Results of a prospective multicentric
study |
Sánchez, MD, Sánchez, et al |
International Journal of Urology |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
The aim of this study was to evaluate the coronavirus disease 2019 perioperative infection rate and mortality rate
of patients undergoing urological surgeries during the early pandemic period in Spain. A total of 148 patients were included in the study, and 141 were analyzed for nosocomial infection risk, after excluding previous and concomitant severe acute respiratory
syndrome coronavirus type 2 infections. Three patients (2.1%) developed severe acute respiratory syndrome coronavirus type 2 nosocomial infection (symptoms developed between the third day after surgery to the 14th day after hospital discharge). Time from admission
to a compatible clinical case was 5.5 days (4–12 days). |
|
Sánchez-Pérez, P, González-Calero, et al |
Nefrologia |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The experience of a tertiary hospital and four hemodialysis centers attached to it during the COVID-19 epidemic is
described. The organization of care that has been carried out and the clinical course of the 16 cases of COVID-19 in hemodialysis patients are summarized. The clinical course of these 16 patients is compared with the series published by the Wuhan University
Hospital and with the data from the Covid-19 infection registry of the Spanish Society of Nephrology. In our experience, and unlike what was reported by the Wuhan Center, COVID-19 disease in hemodialysis patients is severe in a significant percentage of cases,
and high lethality is mostly caused by the infection itself. |
|
|
Factors influencing adoption of online teaching by school teachers: A study during COVID-19
pandemic |
Sangeeta, Tandon, U |
Journal of Public Affairs |
Public Health response| Interventions de santé publique |
The research develops a theoretical model that highlights the determinants of adoption of online teaching at the time
of the outbreak of COVID 19. The proposed conceptual framework was investigated empirically by means of confirmatory factor analysis (CFA) and structural equation modelling (SEM). The findings of the study revealed performance expectancy, and facilitating
conditions had a positive impact on behavioural intention as well as attitude. However, effort expectancy failed to drive teachers' adoption to online teaching. On the other hand, social influence had insignificant relationship with attitude but significant
relationship with behavioural intention. Attitude had a significant impact on behavioural intention as well as actual use. |
|
Develop leadership style model for indonesian SMEs leaders during Covid-19 pandemic |
Sanusi, Suheny, E, et al |
Systematic Reviews in Pharmacy |
Public Health response| Interventions de santé publique |
The purpose of this research is to analyze and blindly model the influence of democratic leadership, Autocratic leadership,
bureaucratic leadership style, Charismatic leadership style on SMEs performance during Covid-19 Pandemic. The conclusion of this study is democratic leadership style, autocratic leadership style, charismatic leadership style, and bureaucratic leadership style
have significant effects on SMEs performance. |
|
Sasson, Isaac |
medRxiv |
Epidemiology| Épidémiologie |
This study aims to answer the following questions: Do COVID-19 deaths follow the Gompertz force of mortality? How does
the relationship between age and COVID-19 mortality compare with other major causes of death? Does this relationship vary between countries? Using US vital Statistics, COVID-19 mortality doubling time is compared with 68 major cause of death categories. COVID-19
fatality is similarly compared across 33 countries using COVerAGE-DB, a harmonized dataset of confirmed COVID-19 cases and deaths. Several findings are supported by the evidence. First, COVID-19 mortality increasing exponentially with age at a rate near the
median of aging-related causes of death, as well as pneumonia and influenza. Second, COVID-19 mortality levels in the US are currently 4 to 8 times higher than pneumonia and influenza across the adult age range. Third, the relationship between COVID-19 fatality
and age varies considerably across high-income countries. Fourth, these regularities can be utilized for indirect estimation of COVID-19 deaths by age. |
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|
Savarraj, JudeP, Burkett, et al |
medRxiv |
Clinical data| Données cliniques |
To characterize long-term neurologic outcomes after COVID-19 we followed a cohort of hospitalized patients and assessed
3-months outcomes. We conducted a prospective single-center study of hospitalized COVID-19 patients admitted to the University of Texas Health Science Center at Houston, Texas from May 2020 to July 2020 during the surge seen in Texas, USA. 3-month outcomes
were determined in 48 subjects using telephone questionnaires to assess functional, cognitive and psychiatric symptoms. Results: 71% had continued neurologic symptoms highlighting the importance of considering the long-haul COVID phenomena. The persistence
of long-term symptoms was not associated with the severity of acute COVID-19 symptoms. The prevalence of cognitive symptoms (12%) were relatively lower than generalized symptoms. |
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|
Schloer, Sebastian, Brunotte, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here we investigated the therapeutic potential of targeting the host- SARS-CoV-2 interface via repurposing of clinically
licensed drugs and evaluated their use in combinatory treatments with virus- and host-directed drugs. We tested the antiviral potential of repurposing the antifungal itraconazole and the antidepressant fluoxetine on the production of infectious SARS-CoV-2
particles in the polarized Calu-3 cell culture model and evaluated the added benefit of a combinatory use of these host-directed drugs with remdesivir, an inhibitor of viral RNA polymerase. Drug treatments were well-tolerated and potent impaired viral replication
was observed with all drug treatments. Importantly, both itraconazole-remdesivir and fluoxetine-remdesivir combinations inhibited the production of infectious SARS-CoV-2 particles > 90% and displayed synergistic effects in commonly used reference models for
drug interaction. Itraconazole-Remdesivir and Fluoxetine-Remdesivir combinations are promising therapeutic options to control SARS-CoV-2 infection and severe progression of COVID-19. |
|
|
Scott, NicholasA, Knight, et al |
medRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
We show here that blood monocytes in convalescent patients at their 12 week follow up, have a greater propensity to
produce pro-inflammatory cytokines TNFα and IL-6, which was consistently higher in patients with resolution of lung injury as indicated by a normal chest X-ray and no shortness of breath. Furthermore, monocytes from convalescent patients also displayed enhanced
levels of molecules involved in leucocyte migration, including chemokine receptor CXCR6, adhesion molecule CD31/PECAM and integrins VLA-4 and LFA-1. Expression of migration molecules on monocytes was also consistently higher in convalescent patients with a
normal chest X-ray. These data suggest persistent changes in innate immune function following recovery from COVID-19 and indicate that immune modulating therapies targeting monocytes and leucocyte migration may be useful in recovering COVID-19 patients with
persistent symptoms. |
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|
Selvapriya, S, Gayathri, et al |
International Journal of Pharmaceutical Research |
Public Health response| Interventions de santé publique |
This study aimed to determine the impact of Covid-19 lockdown on awareness and management of essentials for the family
during the lockdown period. A total of 100 participants-South Indian women were included in the study. Around 68.6% of participants started stocking groceries before the announcement for lockdown was done. 81% of participants were able to spend enough money
for their purchase. In Spite of stocking up things, the majority of them worried about the state of downtrodden and underprivileged people who won’t be able to stock up for their needs. This study shows storage and management of essentials for the family during
this lockdown period. |
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|
Antibody Response to a Nucleocapsid Epitope as a Marker
for COVID-19 Disease Severity |
Sen, Sanjana, Sanders, et al |
bioRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
The experiments identified antibodies to a 21-residue epitope from nucleocapsid (termed Ep9) associated with severe
disease, including ICU stay, requirement for ventilators, and death. Furthermore, anti-Ep9 antibodies correlate both with various comorbidities and ADE hallmarks, including increased IL-6 levels and early IgG response. Importantly, anti-Ep9 antibodies can
be detected within five days post-symptom onset and sometimes within one day. |
|
Analysis of the stochastic model for predicting the novel coronavirus disease |
Sene, N |
Advances in Difference Equations |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, we propose a mathematical model to predict the novel coronavirus. Due to the rapid spread of the novel
coronavirus disease in the world, we add to the deterministic model of the coronavirus the terms of the stochastic perturbations. In other words, we consider in this paper a stochastic model to predict the novel coronavirus. The equilibrium points of the deterministic
model have been determined, and the reproduction number of our deterministic model has been implemented. The asymptotic behaviors of the solutions of the stochastic model around the equilibrium points have been studied. The numerical investigations and the
graphical representations obtained with the novel stochastic model are made using the classical stochastic numerical scheme. |
|
Serviddio, G, Villani, et al |
Therapeutic Advances in Gastroenterology |
Clinical data| Données cliniques |
In the absence of a specific antiviral therapy, some authors have suggested that tocilizumab – a drug used to block
the signal transduction pathway of IL-6 – could have beneficial effects in the management of severe COVID-19 disease. However, mild-to-moderate elevation in transaminases and drug-induced liver injury have been observed in patients treated with tocilizumab.
We present seven cases of patients with elevated liver enzymes up to five times the upper limit of normal (ULN) at baseline who received tocilizumab for life-threatening COVID-19 disease. All patients had no history of liver or pulmonary disease and were admitted
for acute hypoxemic respiratory failure, dyspnea and fever due to COVID-19 bilateral pneumonia. All patients received tocilizumab (8 mg/kg/day) for two consecutive days because of lack of improvement after hydroxychloroquine, azithromycin and lopinavir/ritonavir
treatment. After tocilizumab administration, clinical condition rapidly improved and liver function test normalized within 3 weeks of treatment. |
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Seyed Hashemi, SG, Hosseinnezhad, et al |
Heliyon |
Public Health response| Interventions de santé publique |
The present study proposed a model to understand the associations between problematic internet use (PIU), cyberchondria,
anxiety sensitivity, metacognition beliefs, and fear of COVID-19. fear of COVID-19 was significantly and directly predicted by cyberchondria (β = 0.479, p <.001) and anxiety sensitivity (β = 0.286, p <.001). The relationship between PIU and cyberchondria with
fear of COVID-19 was mediated significantly by anxiety sensitivity and metacognitive beliefs. |
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Challenges faced by working parents in handling children during quarantine-a questionnaire
survey |
Shreenidhi, S, Leslie Rani, et al |
International Journal of Pharmaceutical Research |
Public Health response| Interventions de santé publique |
This study is conducted in order to study the challenges faced by parents during such a long period of quarantine and
how they have managed the kids. The results show that parents found it easy to handle their children, as they have enrolled their children in online classes. This study concludes that parents did not face any challenges during lockdown because the children
were engaged with other online activities and there is no significant difference between the Group I (6-10 years) and Group II (11-15 years) in handling their children . |
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COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic
Therapy? |
Silveira, D, Prieto-Garcia, et al |
Frontiers in Pharmacology |
Therapeutics| Thérapeutique |
The aim of this study is to provide a benefits/risks assessment of selected herbal medicines traditionally indicated
for “respiratory diseases” within the current frame of the COVID-19 pandemic as an adjuvant treatment. A total of 39 herbal medicines were identified as very likely to appeal to the COVID-19 patient. According to our method, the benefits/risks assessment of
the herbal medicines was found to be positive in 5 cases (Althaea officinalis, Commiphora molmol, Glycyrrhiza glabra, Hedera helix, and Sambucus nigra), promising in 12 cases, and unknown for the rest. On the same grounds, only ibuprofen resulted promising,
but we could not find compelling evidence to endorse the use of paracetamol and/or codeine. |
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Capital
market reaction to covid-19 plague event (event study on the LQ-45 index on the IDX) |
Simaremare, JA, Rizki, et al |
Hamdard Islamicus |
Economics | Économie |
This study aims to obtain empirical evidence regarding the capital market reaction to the three announcements in the
COVID-19 outbreak by looking at differences in abnormal return between before and after the announcement. The sample used in this study were 40 companies on the LQ-45 Index in the Indonesia Stock Exchange. The results of this study show three different results.
First, it was shown that there was no significant difference in abnormal returns on Indonesian company stocks before and after the announcement of the COVID-19 outbreak in China and Indonesia. The capital market in Indonesia only showed a reaction when COVID-19
was declared a Public Health Emergency of International Concern (PHEIC). This research contributes to the development of literature regarding the analysis of the impact of capital market reactions in 3 different analysis times when the COVID-19 outbreak occurred. |
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Braving the SARS-CoV-2 pandemic - Quandary of health-care workers |
Singh, A, Chaturvedi, et al |
Indian Journal of Medical and Paediatric Oncology |
Epidemiology| Épidémiologie |
The aim of the study was to determine the number of health-care workers infected and dead globally due to SARS-CoV-2
infection. Reports covering 67 countries showed that 99,847 health-care workers (HCWs) have been reported to be infected with SARS-CoV-2 virus, with a majority reported in Europe. This included confirmed reports of 1732 doctors and 348 nurses. Five hundred
and thirty-eight deaths were reported in 32 countries, amounting to a mortality among HCWs globally of 4%. |
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Income and Employment Changes Under COVID-19 Lockdown: A Study of Urban Punjab |
Singh, I, Singh, et al |
Millennial Asia |
Economics | Économie |
This article traces income and employment changes through various phases of the lockdown based on primary data. It
analyses the coping strategies of people in response to fall in their income. The article reveals that there was a large drop in income and employment with the announcement of lockdown. While there is some recovery with easing of the lockdown, the income at
the time of survey is still substantially lower than its pre-lockdown level. Casual labour households with the largest fall in income and employment are the most affected. Income and employment losses are also higher among Scheduled Caste (SC) and Other Backward
Caste (OBC) households. In the absence of any income, the households either had to live off their savings or had to borrow money for their basic needs. With rapidly depleting savings, borrowing approached its limits, and with slow recovery of income, households
may need substantial government assistance to save them from deprivation. © 2020 Association of Asia Scholars. |
|
Skalidis, I, Nguyen, et al |
American Journal of Emergency Medicine |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This retrospective single-center study included 155 patients in ED who underwent both RT-PCR and chest CT for suspected
COVID-19 from March 1st to April 1st, 2020. 42% had positive RT-PCR results, and 46% had positive CT findings. Chest CT showed a sensitivity of 84.6%, a specificity of 80.0% and a diagnostic accuracy of 81.9% in suggesting COVID-19 with RT-PCR as reference.
Concurrently, corresponding values of 89.4%, 84.3% and 86.5% were retrieved with the adjudication committee diagnosis as reference. For the subgroup of patients with age > 65, specificity and sensitivity were 50% and 80.8%, respectively. In patients with negative
RT-PCR results, 20% (18/90) had positive chest CT finding and 22% (4/18) of those were eventually considered as COVID-19 positive according to the adjudication committee. After CT, the estimated probability of COVID-19 changed in 10/104 (11%) patients with
available data: 4 (4%) were downgraded, 6 (6%) upgraded. |
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|
Somadi, G, Sivan, et al |
Journal of Theoretical and Computational Chemistry |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We analyzed the structure of Sgp S2 domain in pre-fusion state and Heptad repeat region in its post-fusion state available
from protein data bank. Sgp shows three major regions in S2 domain, the fusion peptide (FP), heptad repeat 1 (HR1) and central helical (CH) region. The HR1 region undergoes structural changes by flipping approximately 180° and coil up to form a rod like structure
during fusion process implying its role in viral entry into the host cell. This structural change in S2 domain helices is crucial step, if this process is hindered by targeting the HR1 and CH region then the progression of virus can be stopped. Possible binding
cavity was identified near the HR1 and CH region in S2 domain and docking-based virtual screening of FDA approved drugs was performed. Promising candidates like Troxerutin, Thymopentin and Daclatasvir can be used as therapeutics provided an immediate in-vitro
and clinical studies are carried out by research groups. |
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|
Somogyi, Eszter, Csiszovszki, et al |
bioRxiv |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
The PolyPEPI-SCoV-2-specific T cell repertoire used for recovery from COVID-19 was extremely diverse: donors had an
average of seven different peptide-specific T cells, against the SARS-CoV-2 proteins, 87% of donors had multiple targets against at least three SARS-CoV-2 proteins and 53% against all four. |
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|
Sonbhadra, Sanjay Kumar, Agarwal, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This article proposes a novel PB-OCSVM model to work in presence of limited COVID-19 positive CXR samples with objectives
to maximize the learning efficiency while minimize the false-positive and false-negative predictions. The proposed model outperformed over recently published deep learning approaches where accuracy, precision, specificity and sensitivity are used as performance
measure parameters. |
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|
Sonbhadra, Sanjay Kumar, Agarwal, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The conventional way of COVID-19 diagnosis is reverse transcription polymerase chain reaction (RT-PCR), which is less
sensitive during early stages specially, if the patient is asymptomatic that may further lead to more severe pneumonia. To overcome this problem an early diagnosis method is proposed in this paper via one-class classification approach using a novel pinball
loss function based one-class support vector machine (PB-OCSVM) considering posteroanterior chest X-ray images. This article proposes a novel PB-OCSVM model to work in presence of limited COVID-19 positive CXR samples with objectives to maximize the learning
efficiency while minimize the false-positive and false-negative predictions. The proposed model outperformed over recently published deep learning approaches where accuracy, precision, specificity and sensitivity are used as performance measure parameters. |
|
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Genetic Association of ACE2 rs2285666 Polymorphism With COVID-19 Spatial Distribution
in India |
Srivastava, A, Bandopadhyay, et al |
Frontiers in Genetics |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Studies have shown a difference of allele frequency among Europeans and Asians for the polymorphism rs2285666, present
in ACE2. We have looked at the phylogenetic structure of rs2285666 derived haplotypes in worldwide populations and compared the spatial frequency of this particular allele with respect to the COVID-19 infection as well as case-fatality rate in India. For the
first time, we ascertained a significant positive correlation for alternate allele (T or A) of rs2285666, with the lower infection as well as case-fatality rate among Indian populations. |
|
Storch, DD |
Current Psychiatry |
Clinical data| Données cliniques |
This case series reports on general observations from 100 patients receiving psychiatric help at a community mental
health center. The author reports on the success of telehealth and what groups of patients fared better than others. |
|
|
Stribling, J, Clifton, et al |
Journal of advanced nursing |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
To examine the UK pandemic preparedness in light of health expenditure, nursing workforce, and mortality rates in and
relation to nursing leadership. A cross-nation comparison of the top 36 countries ranked by Global Health Security Index score using a variety of online sources, including key data about each nation's expenditure on health and the nursing workforce, and compared
these with mortality data for COVID-19. The extent of a country's pandemic preparedness, expenditure on healthcare and magnitude of the nursing workforce does not appear to impact mortality rates at this stage of the pandemic which is something of a paradox. |
|
|
Suardi, LR, Pallotto, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objectives: To investigate risk factors for non-invasive/invasive ventilatory support (NI/I-VS) in patients with coronavirus
disease 2019 (COVID-19). Ninety-seven patients were enrolled. The in-hospital mortality was 9.3%. Thirty-five of the 97 patients (36%) required ICU admission and 94.8% (92/97) were prescribed oxygen therapy.On univariate analysis, patients with a body mass
index >30, type II diabetes mellitus, and those presenting with dyspnoea, asthenia, SOFA score ≥2 points, PaO2/FiO2 <300, temperature >38 °C, increased levels of lactate dehydrogenase (LDH), alanine aminotransferase, and C-reactive protein, and a D-dimer >1000
ng/mL at admission more frequently underwent NI/I-VS. |
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|
Subramanian, I, Farahnik, et al |
npj Parkinson's Disease |
Public Health response| Interventions de santé publique |
The goal of this study was to survey individuals with Parkinson’s disease (PD) to evaluate whether social isolation
is associated with PD symptom severity and quality of life. Only individuals reporting a diagnosis of idiopathic PD were included in this analysis. PRO-PD scores increased as social performance and social satisfaction scores diminished. Individuals who reported
being lonely experienced a 55% greater symptom severity than those who were not lonely (P < 0.01). Individuals who documented having a lot of friends had 21% fewer symptoms than those with few or no friends (P < 0.01). Social isolation was associated with
greater patient-reported PD severity and lower quality of life, although it is unclear whether this is the cause and/or a consequence of the disease. In essence, the Parkinson pandemic and the pandemic of social isolation have been further compounded by the
recent COVID-19 pandemic. |
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Sumaedi, S, Bakti, et al |
Health Education |
Public Health response| Interventions de santé publique |
This research aims to test the effects of attitude, perceived behavioral control (PBC), subjective norm and perceived
quality of official coronavirus disease 2019 (COVID-19) websites on intention to use official COVID-19 websites of Indonesians (n = 120). This research found that intention to use official COVID-19 websites is significantly and positively affected by the
quality of the website, attitude and subjective norm. PBC does not influence intention to use official COVID-19 websites. |
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White blood cells and severe COVID-19: a Mendelian
randomization study |
Sun, Yitang, Zhou, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Authors aimed to investigate whether white blood cell traits have potential causal effects on severe COVID-19 using
Mendelian randomization (MR). The MR results indicated potential causal associations of white blood cell count, myeloid white blood cell count, and granulocyte count with severe COVID-19, with odds ratios (OR) of 0.84 (95% CI: 0.72-0.98), 0.81 (95% CI: 0.70-0.94),
and 0.84 (95% CI: 0.71-0.99), respectively. Increasing eosinophil percentage of white blood cells was associated with a higher risk of severe COVID-19 (OR: 1.22, 95% CI: 1.03-1.45). |
|
Tan, AnthonyT, Linster, et al |
bioRxiv |
Coronavirology| Coronavirologie Immunology | Immunologie |
Virus-specific humoral and cellular immunity act synergistically to protect the host from viral infection. We interrogated
the dynamic changes of virological and immunological parameters in 12 patients with symptomatic acute SARS-CoV-2 infection from disease onset to convalescence or death. We quantified SARS-CoV-2 viral RNA in the respiratory tract in parallel with antibodies
and circulating T cells specific for various structural (NP, M, ORF3a and spike) and non-structural proteins (ORF7/8, NSP7 and NSP13). We observed that while rapid induction and quantity of humoral responses were associated with increased disease severity,
an early induction of SARS-CoV-2 specific T cells was present in patients with mild disease and accelerated viral clearance. These findings provide further support for a protective role of SARS-CoV-2 specific T cells over antibodies during SARS-CoV-2 infection
with important implications in vaccine design and immune-monitoring.Competing Interest StatementA.B. is a cofounder and A.T.T. consults for Lion TCR, a biotech company developing T cell receptors for treatment of virus-related diseases and cancers. None of
the other authors has any competing interest related to the study. |
|
|
Adult Stem Cell-derived Complete Lung Organoid Models
Emulate Lung Disease in COVID-19 |
Tindle, Courtney, Fuller, et al |
bioRxiv |
Coronavirology| Coronavirologie Immunology | Immunologie |
SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage in the lungs in the setting of an overzealous
immune response whose origin remains unclear. We present a scalable, propagable, personalized, cost-effective adult stem cell-derived human lung organoid model that is complete with both proximal and distal airway epithelia. Monolayers derived from adult lung
organoids (ALOs), primary airway cells, or hiPSC-derived alveolar type-II (AT2) pneumocytes were infected with SARS-CoV-2 to create in vitro lung models of COVID-19. Infected ALO-monolayers best recapitulated the transcriptomic signatures in diverse cohorts
of COVID-19 patient-derived respiratory samples. The airway (proximal) cells were critical for sustained viral infection whereas distal alveolar differentiation (AT2→AT1) was critical for mounting the overzealous host immune response in fatal disease; ALO
monolayers with well-mixed proximodistal airway components recapitulated both. Findings validate a human lung model of COVID-19 which can be immediately utilized to investigate COVID-19 pathogenesis, and vet new therapies and vaccines.Competing Interest StatementThe
authors have declared no competing interest. |
|
Trisnawati, I, El Khair, et al |
Annals of Medicine and Surgery |
Clinical data| Données cliniques |
Prolonged nucleic acid conversion in patients with COVID-19 from Indonesia, becoming the longest reported of 70 days.
We further confirmed the occurrence of prolonged nucleic acid conversion and false negative RT-PCR in COVID-19 patients. Several factors might affect the prolonged nucleic acid conversion, including older age and comorbidities. |
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A surveillance system to detect COVID-19 infections in health care workers.
Experience in 209 cases |
Umanzor, RP, Peñafiel, et al |
Revista medica de Chile |
Epidemiology| Épidémiologie Surveillance Healthcare Response | Réponse des soins de
santé |
We describe an epidemiological surveillance strategy to detect symptoms compatible with SARS-CoV-2 infection and early
case detection among healthcare personnel at a university hospital. We assessed 209 healthcare workers reporting symptoms suggestive of COVID-19 in a telephone counseling system. In 61% of assessed workers a coronavirus SARS-CoV-2 nasopharyngeal swab PCR was
requested and 28 (22%) were positive. |
|
Villalobos, C |
Frontiers in Public Health |
Epidemiology| Épidémiologie |
This paper provides an estimation of the accumulated detection rates and the accumulated number of infected individuals
by the novel SARS-CoV-2. Our results show that, on average, detecting 5 instead of 35 percent of the infections is associated with multiplying the number of deaths by a factor of about 6. Using this result, we estimated that 120 days after the pandemic outbreak,
if the US would have tested with the same intensity as South Korea, about 85,000 out of their 126,000 reported deaths could have been avoided. |
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Impact on air quality of the covid-19 lockdown in the urban area of palermo (Italy) |
Vultaggio, M, Varrica, et al |
International Journal of Environmental Research and Public Health |
Public health interventions*| Interventions de santé publique |
The goal of our investigation was to evaluate the impact of the COVID-19 lockdown on the concentrations of the main
air pollutants in the urban area of Palermo (Italy). In this study, the trends in the average concentrations of CO, NO2, O3, and PM10 in the air from 1 January 2020 to 31 July 2020 were compared with the corresponding average values detected at the same monitoring
stations in Palermo during the previous five years (2015–2019). During the lockdown period (10 March–30 April), we observed a decrease in the concentrations of CO, NO2, and particulate matter (PM)10, calculated to be about 51%, 50%, and 45%, respectively.
This confirms that air pollution in an urban area is predominantly linked to vehicular traffic. |
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Wada, K, Okabe, et al |
BMJ Paediatrics Open |
Epidemiology| Épidémiologie Transmission |
We aimed to investigate the confirmed COVID-19 cases among students and teachers in elementary schools (ages 6-12 years)
and junior high schools (ages 13-15 years) in Japan between 1 June and 31 July 2020. We requested all schools to provide reports when students or teachers tested positive for COVID-19. A total of 207 cases were reported among students. Household transmission
was identified as the dominant transmission route, confirmed in 71.4% of elementary schools and 60.3% of junior high schools. A total of 39 cases were reported among teachers, of which transmission route was unknown in 72.4% of elementary schools and 90.0%
of junior high schools. © 2020 Author(s) (or their employer(s)). Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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Waelde, Klaus |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
A SIR model is presented where the true numbers of susceptible, infectious and removed individuals are unobserved.
Testing is also modelled. Official confirmed infection numbers are likely to be biased and cannot be compared over time. The bias occurs because of different reasons for testing (e.g. by symptoms, representative or testing travellers). The paper illustrates
the bias and works out the effect of the number of tests on the number of reported cases. The paper also shows that the positive rate (the ratio of positive tests to the total number of tests) is uninformative in the presence of non-representative testing. |
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Wang, J, Chaudhry, et al |
Journal of Stroke and Cerebrovascular Diseases |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
To evaluate the impact of the COVID-19 pandemic on hospital admissions and outcomes in patients admitted with acute
ischemic stroke. We observed a 22.1% and 39.5% decline in admission for acute ischemic stroke in April and May 2020, respectively. A significantly higher percentage of patients with acute ischemic stroke received intravenous thrombolysis during the COVID-19
era (p = 0.020). In patients with confirmed COVID-19, we found a higher percentage of older men with preexisting comorbidities such as hyperlipidemia, coronary artery disease, and diabetes mellitus but a lower rate of atrial fibrillation. In addition, we found
a treatment delay in both intravenous thrombolysis (median 94.5 min versus 38 min) and mechanical thrombectomy (median 244 min versus 86 min) in patients with confirmed COVID-19 infection. There were no differences in patients’ disposition including home,
short-term, and long-term facility (p = 0.60). |
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Wang, S, Li, et al |
EMBO Journal |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, we report that one of the interferon‐stimulated genes (ISGs), cholesterol 25‐hydroxylase (CH25H), is induced
by SARS‐CoV‐2 infection in vitro and in COVID‐19‐infected patients. Our results shed light on a potentially broad antiviral mechanism by 25HC through depleting accessible cholesterol on the plasma membrane to suppress virus–cell fusion. Since 25HC is a natural
product with no known toxicity at effective concentrations, it provides a potential therapeutic candidate for COVID‐19 and emerging viral diseases in the future. |
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Wang, Xueping, Hu, et al |
Research Square prepub |
Public Health Priorities| Priorités de santé publique Healthcare Response | Réponse
des soins de santé |
This study aimed to investigate the change of disease distribution in pediatric neurology inpatients during the COVID-19
outbreak in southwest China. We retrospectively extracted the demographic data and diagnosis of discharged patients registered at pediatric neurology department of Chengdu Women’s and Children’s Central Hospital from January 1 to July 31, 2019 and January
1 to July 31, 2020. Total number of inpatients decreased during COVID-19 outbreak. Children diagnosed as febrile seizure caused by infection (1799/60.7% vs 980/59%, P = 0.141), dyskinesia (31/1.0% vs 28/1.7%, P = 0.075) and benign intracranial hypertension
(41/1.4% vs 21/1.3%, P = 0.791) did not change. While children diagnosed as epilepsy (304/10.3% vs 348/21%, P < 0.001), migraine (25/0.8% vs 31/1.9%, P = 0.003), mental disease (24/0.8% vs 43/2.6%, P < 0.001) and peripheral neuropathy (38/1.3% vs 43/2.6%,
P = 0.001) increased in 2020. Children diagnosed as intracranial infection (535/18% vs113/6.8%, P < 0.001) and myopathy (106/3.6% in vs 22/2.0%, P = 0.003) reduced in 2020. Conclusions: We found a significant increase in the proportion of mood-related diseases,
while disease caused by infection decreased. We should pay attention to children’s mental state during the public health epidemic and the management of chronic disease. |
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Spillover effects of RMB exchange rate among B&R countries: Before and during COVID-19
event |
Wei, Z, Luo, et al |
Finance Research Letters |
Economics | Économie |
This situation started to change since March 8, 2020, with the global spread of the COVID-19, U.S. stocks triggered
circuit breakers which halted trading for four times in 10 days, the same triggering of circuit breakers also appeared in many countries in the world. Meanwhile, Chinese policymakers stepped in early to safeguard financial stability, taking actions like backstopping
interbank markets, providing financial support to firms under pressure, and letting the RMB adjust to external pressures. As the pandemic eased and the economy started to recover in China, the influence of CNY measured by CNY To started to pick up. Meanwhile,
CNY From , which implies the risk of CNY to be affected by other currencies, has decreased slightly. |
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Wendt, R, Kalbitz, et al |
Proteomics |
Clinical data| Données cliniques |
In this accelerated article, the identification of urinary peptides significantly associated with SARS-CoV-2 infection,
and the development of a multi-marker urinary peptide based test, COVID20, that may enable prognosis of critical and fatal outcomes in COVID-19 patients is reported. COVID20 is composed of 20 endogenous peptides mainly derived from various collagen chains
that enable differentiating moderate or severe disease from critical state or death with 83% sensitivity at 100% specificity. Based on the performance in this pilot study, testing in a prospective study on 1000 patients has been initiated. |
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Wong, RCW, Wong, et al |
Journal of medical virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This letter to the editor describes the evaluation of the diagnostic performance of Panther Fusion assay (PF assay)
for the detection of SARS‐CoV‐2 in comparison to the TIB‐Molbiol LightMix SarbecoV E‐gene assay (TIB‐Molbiol assay) (TIB‐Molbiol) using deep throat saliva (DTS), lower respiratory tract (LRT), and nasopharyngeal (NP) specimens. One hundred and fifty‐eight
specimens (87 positive and 71 negative specimens) collected from 142 patients with suspected COVID‐19 disease were tested. Using consensus results as gold standard, PPA of NP, LRT, and DTS specimens were 96.43%, 100%, and 96.00%, respectively. The overall
PPA and NPA were 97.53% and 100%, respectively and overall Cohen's kappa value was 0.97. The Panther Fusion SARS‐CoV‐2 assay has comparable performance with the reference method. With its capability of random access and high‐throughput, it maximizes the flexibility
of SARS‐CoV‐2 testing in clinical laboratories. |
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Wu, JT, Leung, et al |
Obstetrical and Gynecological Survey |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public Health
response| Interventions de santé publique |
The aims of this study were to estimate the potential size of the epidemic and to forecast the course of its spread
within China and worldwide. This was a modeling study based on the number of cases exported from Wuhan to cities outside of mainland China from December 1, 2019, to January 25, 2020. A baseline scenario was established, estimating that the basic reproductive
number for SARS-CoV2 was 2.68 (95% credibile interval, 2.47-2.86) and that 75,815 individuals (95% credibile interval, 37,304-130,330) in Wuhan had been infected as of January 25, 2020. It was estimated that Wuhan exported 461 cases to Chongqing, 113 to Beijing,
98 to Shanghai, 111 to Guangzhou, and 80 to Shenzhen; these cities are major hubs for travel and mobility that can contribute to the spread of the disease. Given the number of cases already exported fromWuhan, the authors inferred that local epidemics are
already growing exponentially in major Chinese cities, peaking in April 2020 with outbreaks in other cities lagging by 1 to 2 weeks. The spread of SARS-CoV2 would hit other countries during the first half of 2020. |
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Xiao, AT, Tong, et al |
J Clin Virol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Of 301 hospitalized COVID-19 patients, the median age was 58 years and 51.2 % were male. The median period between
symptoms presence and positive SARS-CoV-2 RT-PCR results was 16 days (IQR, 10-23, N = 301). The median period between symptoms presence and an effective negative SARS-CoV-2 RT-PCR result was 20 days (IQR, 17-24; N = 216). Infected patient ≥65 years old stayed
contagious longer (22 days vs 19 days, p = 0.015). Although two consecutive negative results were confirmed in 70 patients, 30 % of them had positive viral test results for the third time. Using specimens from nasal swabs to run the RT-PCR test showed a higher
positive rate than using specimens from throat swabs. |
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Xue, G, Gan, et al |
International immunopharmacology |
Clinical data| Données cliniques |
Authors retrospectively analyzed 114 patients with COVID-19 at the Jinyintan Hospital, Wuhan based on their clinical
and laboratory data. Taken together, PNI, HsCAR, and HsCPAR may serve as accurate biomarkers for the prediction of disease severity in patients with COVID-19 upon admission/hospitalization. |
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Yan, Wei, Nawaz, et al |
Research Square prepub |
Epidemiology| Épidémiologie Transmission |
explore the correlation of environmental factors with the transmission of SARS-CoV-2 based on parameters including
infection rate, effective reproduction number, and compound growth rate, we analyzed data of confirmed cases from 487 counties in the United States. We found a small impact of temperature and humidity on virus transmission, but observed a considerable positive
influence of atmospheric pressure and population density on virus transmission. Geographic areas and seasons (autumn and winter), with exposure to higher atmospheric pressure, are more likely at higher risk of an outbreak. |
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Yu, X, Li, et al |
Frontiers in Psychology |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to understand levels of anxiety in frontline staff in China and whether they have been
using medication to prevent COVID-19. This study revealed that there was more anxiety among frontline medical staff who took medication after unexpected occupational exposure. There was less anxiety among those using an integrated course of Chinese and Western
medicine than Western medicine alone. It was also observed that anxiety affects the types and frequency of the preventive medication taken. |
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Analysis of second outbreak of COVID-19 after relaxation of control measures in
India |
Yu, X, Qi, et al |
Nonlinear Dynamics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This paper proposes a compartment model to study the development of COVID-19 in India after relaxing control. The Sigmoid
function reflecting the cumulative effect is used to characterize the model-based diagnosis rate, cure rate and mortality rate. Considering the influence of the lockdown on the model parameters, the data are fitted using the method of least squares before
and after the lockdown. According to numerical simulation and model analysis, the impact of India’s relaxation of control before and after the inflection point is studied. Research shows that adopting a relaxation policy prematurely will have disastrous consequences.
Even if the degree of relaxation is only 5% before the inflection point, it will increase the number of deaths by 15.03%. If the control is relaxed after the inflection point, the higher degree of relaxation, the more likely a secondary outbreak will occur,
which will extend the duration of the pandemic, leading to more deaths and put more pressure on the health care system. It is found that after the implementation of the relaxation policy, medical quarantine capability and public cooperation are two vital indicators.
The results show that if the supply of kits and detection speed can be increased after the control is relaxed, the secondary outbreak can be effectively avoided. Meanwhile, the increase in public cooperation can significantly reduce the spread of the virus,
suppress the second outbreak of the pandemic and reduce the death toll. |
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Yuriditsky, E, Horowitz, et al |
Journal of critical care |
Healthcare Response | Réponse des soins de santé |
Authors discuss the surge in the deployment of large numbers of non-intensive care providers to assist in the management
of the critically ill. Simulation-based training improved provider comfort in the management of critically ill patients with COVID-19. |
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Zaeck, LucaM, Scheibner, et al |
bioRxiv |
Clinical data| Données cliniques |
Authors could confirm a preferential infection of the ferret upper respiratory tract by SARS-CoV-2 and emphasize a
distinct focal infection pattern in nasal turbinates. Conclusively, authors present a proof-of-concept study for investigating critically important respiratory pathogens in their spatial tissue morphology and demonstrate the first specific 3D visualization
of SARS-CoV-2 infection. |
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Zanghì, A, D'Amico, et al |
Multiple Sclerosis and Related Disorders |
Public Health response| Interventions de santé publique |
To assess the mental health status of Relapsing-Remitting Multiple Sclerosis (RRMS) patients regularly followed at
the MS center of Catania (Italy) and returning to work after the easing of lockdown during COVID-19 pandemic. Valid and complete interviews were obtained from 432 patients (response rate 64.3%). One-hundred thirty-seven (31.7%) RRMS patients received a score
≥4 at the Short-Screening-Scale for DSM IV (SSS-DSM-IV), indicating clinically significant PTSD-like symptoms. About Stress Scale- 21 (DASS-21), moderate-to-severe anxiety was reported by 210 RRMS patients (48.6%), moderate-to-severe depression, and moderate-to-severe
stress were respectively reported by 95 (22%) and 220 (50.9%) RRMS patients. Insomnia was reported by 128 patients (29.6%). Factors associated with major severity of symptoms were: marital status, previous diagnosis of mood disorders, switching/starting Disease-Modifying
Therapies in the last 12 months, and a higher level of disability measured with Expanded Disability Status Scale (for all, p<.05). |
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The dynamics of immune response in COVID-19 patients with different
illness severity |
Zhang, B, Yue, et al |
Journal of medical virology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
This study aimed to analyze the dynamic changes of lymphocyte subsets and specific antibodies in coronavirus disease
2019 (COVID-19) patients with different illness severity. The amounts of lymphocyte subsets and the levels of immunoglobulin M (IgM) and IgG antibody were retrospectively analyzed in 707 COVID-19 cases. The amounts of lymphocyte subsets were significantly
decreased with the increased severity of illness and the levels of IgM and IgG were lower in critical cases than severe and moderate cases. In deceased patients, the lymphocytes subsets were significantly lower than recovered patients. However, the relationship
between the levels of IgM and IgG and the amounts of lymphocyte subsets were not significantly correlated. During different stages of COVID-19, the total T cell, CD4+ T cell, and CD8+ T cell counts were gradually recovered to the normal levels in severe and
critical groups but the changing trend was relatively stable in the moderate group. The production of IgM and IgG antibodies were delayed in critical groups but also could reach the peak levels at one month after illness onset and decreased to background levels.
To detect the kinetics of lymphocytes and antibodies has important clinical value in predicting the illness severity and understanding the pathogenesis of COVID-19. © 2020 Wiley Periodicals LLC |
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Zhang, N, Wang, et al |
Frontiers in Endocrinology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The study was retrospectively carried out on enrolled diabetes patients with laboratory confirmed COVID-19 infection
from a designated medical center for COVID-19 in Wuhan, China. Univariate and multivariate analyses were performed to assess the risk factors associated with the severe events which were defined as a composite endpoint of admission to intensive care unit,
the use of mechanical ventilation, or death. Severe events diabetes patients showed higher counts of white blood cells and neutrophil, lower lymphocytes, high levels of hs-CRP, erythrocyte sedimentation rate and procalcitonin as compared to the non-severe
diabetes patients. |
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Zhao, J, Jia, et al |
Risk Management and Healthcare Policy |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In order to assess the impact of infection prevention and control (IPC) policies, this research addresses the results
of a policy simulation in Shanghai, China, which estimates the transmission dynamics of COVID-19 under various IPC policies and offers evidence-based outcomes of work resumption policies for the world. This simulation research is based on a system dynamics
(SD) model that integrates IPC work resumption policies implemented in Shanghai into the classical susceptible-exposed-infected-removed (SEIR) epidemiological model. The simulations show that a non-quarantined and non-staged approach to work resumption (Policy
1) would bring a small secondary outbreak of COVID-19. The quarantined but non-staged approach (Policy 2) and the non-quarantined but staged approach (Policy 3) would not bring a secondary outbreak of COVID-19. However, they both would generate more newly
confirmed cases than the staged and quarantined approach (Policy 4). Moreover, the 14-day quarantine policy alone appears to be more effective in reducing transmission risk than the staged work resumption policy alone. |
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Zhao-Ling, Q, Hao-Ran, et al |
Academic Journal of Second Military Medical University |
Coronavirology| Coronavirologie |
The objective of this study was to express and purify recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
nucleocapsid (N) protein, and prepare SARS-CoV-2 N protein antiserum by immunizing mice. Results were successful with E. coli being induced to express a soluble SARS-CoV-2 N recombinant protein, with a relative molecular weight of about 55,000, and the recombinant
protein was purified; the results of Western blot analysis showed that the SARS-CoV-2 N recombinant protein can interact with SARS-CoV. -2 N monoclonal antibody and SARS-CoV N polyclonal antibody are combined; the results of indirect immunofluorescence experiments
show that the prepared mouse antiserum can bind to the SARS-CoV-2 N recombinant protein expressed in mammalian cells. |
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The impact of COVID-19 on the efficiency of microfinance institutions |
Zheng, C, Zhang, et al |
International Review of Economics and Finance |
Economics | Économie |
This study investigates the effect of the COVID-19-induced decline in economic activities on the financial and social
efficiency of microfinance institutions (MFIs). We find that the pandemic-induced impact decreases the financial efficiency of MFIs; however, the social efficiency of MFIs is increased under the impact of COVID-19. To explore potential channels through which
efficiency is influenced by the COVID-19 outbreak, we examine the supply and demand side of MFIs’ funding. We find that the lending rate mediates the relationship between the impact of COVID-19 and MFI efficiency, whereas the mediating role of the funding
rate is negligible. © 2020 |
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Progressive and accurate assembly of multi-domain protein
structures from cryo-EM density maps |
Zhou, Xiaogen, Li, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We developed DEMO-EM, an automatic method to assemble multi-domain structures from cryo-EM maps through a progressive
structural refinement procedure combining rigid-body domain fitting and flexible assembly simulations with deep neural network inter-domain distance profiles. The method was tested on a large-scale benchmark set of proteins containing up to twelve continuous
and discontinuous domains with medium-to-low-resolution density maps, where DEMO-EM produced models with correct inter-domain orientations (TM-score >0.5) for 98% of cases and significantly outperformed the state-of-the-art methods. DEMO-EM was applied to
SARS-CoV-2 coronavirus genome and generated models with average TM-score/RMSD of 0.97/1.4Å to the deposited structures. |
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Allegra, A, Tonacci, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
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Alluwaimi, AM, Alshubaith, et al |
Frontiers in Veterinary Science |
Review Literature| Revue de littérature |
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Amor, S, Fernández Blanco, et al |
Clinical and experimental immunology |
Review Literature| Revue de littérature |
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Balogun, JA |
African Journal of Reproductive Health |
Review Literature| Revue de littérature |
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Barbato, L, Bernardelli, et al |
Oral diseases |
Review Literature| Revue de littérature |
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Benjamens, S, de Meijer, et al |
Scientometrics |
Review Literature| Revue de littérature |
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The scientific and ethical feasibility of immunity passports |
Brown, RebeccaCH, Kelly, et al |
The Lancet Infectious Diseases |
Review Literature| Revue de littérature |
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The Pipeline of Therapeutics Testing During the Emergency Phase of the COVID-19 Outbreak |
Canevelli, M, Remoli, et al |
Frontiers in Medicine |
Review Literature| Revue de littérature |
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Chowdhury, MA, Hossain, et al |
Nano |
Review Literature| Revue de littérature |
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Czeresnia, RM, Trad, et al |
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia |
Review Literature| Revue de littérature |
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de la Rica, R, Borges, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Di Carlo, F, Sociali, et al |
International journal of clinical practice |
Review Literature| Revue de littérature |
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Dong, Yudi, Yao, et al |
arXiv |
Review Literature| Revue de littérature |
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Survival in pediatric patients with cancer during the covid-19 pandemic: Scoping systematic
review |
Dorantes-Acosta, E, Ávila-Montiel, et al |
Boletin medico del Hospital Infantil de Mexico |
Review Literature| Revue de littérature |
ScR: MEDLINE, TRIP Database, International Clinical Trials Registry Platform (WHO), The Cochrane Library, Wiley, LILACS,
and Google Scholar were searched from December 2019 to June 10, 2020. Given the nature of preliminary reports and a short follow-up in cancer patients, it is necessary to have medium-and long-term follow-up studies to determine the effects of infection and
modifications to the treatments of these patients. |
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Dutta, D, Sharma, et al |
European Endocrinology |
Review Literature| Revue de littérature |
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E Côrte, , ACR, et al |
Revista Brasileira de Medicina do Esporte |
Review Literature| Revue de littérature |
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Elmorsi, R |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
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Fambuena-Muedra, I, Jiménez-García, et al |
European journal of ophthalmology |
Review Literature| Revue de littérature |
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Fedele, D, De Francesco, et al |
Nutrition |
Review Literature| Revue de littérature |
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García, CS, Sánchez, et al |
Metas de Enfermeria |
Review Literature| Revue de littérature |
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Advancement in biosensors for inflammatory biomarkers of SARS-CoV-2 during 2019–2020 |
Garg, M, Sharma, et al |
Biosensors and Bioelectronics |
Review Literature| Revue de littérature |
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Girdhar, A, Kapur, et al |
Air Quality, Atmosphere and Health |
Review Literature| Revue de littérature |
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Gómez-Moreno, G |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
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Grimes, CL, Balk, et al |
Obstetrical and Gynecological Survey |
Review Literature| Revue de littérature |
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Physical inactivity, chronic diseases, immunity and covid-19 |
Guimarães, TT, Dos Santos, et al |
Revista Brasileira de Medicina do Esporte |
Review Literature| Revue de littérature |
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Heegaard, PMH, Sturek, et al |
Frontiers in Microbiology |
Review Literature| Revue de littérature |
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Henssler, J, Stock, et al |
European archives of psychiatry and clinical neuroscience |
Review Literature| Revue de littérature |
SR-MA: PubMed, PsycINFO, and Embase databases were searched for studies until April 22, 2020. There is compelling
evidence for adverse mental health effects of isolation and quarantine, in particular depression, anxiety, stress-related disorders, and anger.
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Hojyo, S, Uchida, et al |
Inflammation and Regeneration |
Review Literature| Revue de littérature |
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Howgego, G, Sharma, et al |
Journal of Plastic, Reconstructive and Aesthetic Surgery |
Review Literature| Revue de littérature |
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Hu, C, Liang, et al |
Evidence-based Complementary and Alternative Medicine |
Review Literature| Revue de littérature |
MA: Seven English and Chinese databases were used to search for qualified experimental studies as of July 27, 2020.
Lianhua Qingwen combined with conventional drugs may be a promising therapy for treating common pneumonia and COVID-19 pneumonia. |
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Hung, KF, Sun, et al |
Journal of the Chinese Medical Association |
Review Literature| Revue de littérature |
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Ivanisenko, NV, Seyrek, et al |
Cell Death Discovery |
Review Literature| Revue de littérature |
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Big data analytics in healthcare: a systematic literature review |
Khanra, S, Dhir, et al |
Enterprise Information Systems |
Review Literature| Revue de littérature |
SR: Scopus, Web of Science, PsycINFO, and PubMed were searched. The findings from this study suggest that applications
of BDA in healthcare can be observed from five perspectives, namely, health awareness among the general public, interactions among stakeholders in the healthcare ecosystem, hospital management practices, treatment of specific medical conditions, and technology
in healthcare service delivery. |
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Kuchenmeister, M |
Journal of Diagnostic Medical Sonography |
Review Literature| Revue de littérature |
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With Corona Outbreak: Nature Started Hitting the Reset Button Globally |
Kumar, A, Malla, et al |
Frontiers in Public Health |
Review Literature| Revue de littérature |
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Leisman, DanielE, Ronner, et al |
The Lancet Respiratory Medicine |
Review Literature| Revue de littérature |
SR-MA: articles published between Nov 1, 2019, and April 14, 2020, in the Embase and MEDLINE databases. Additional
searching was done in the medRxiv repository for relevant preprints. Our findings question the role of a cytokine storm in COVID-19-induced organ dysfunction. Many questions remain about the immune features of COVID-19 and the potential role of anti-cytokine
and immune-modulating treatments in patients with the disease. |
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Short- and potential long-term adverse health outcomes of COVID-19: a rapid
review |
Leung, TYM, Chan, et al |
Emerging Microbes and Infections |
Review Literature| Revue de littérature |
Rapid Review: literature search using PubMed up till June 2020. Major adverse outcomes were found to affect different
body systems: immune system (including but not limited to Guillain-Barré syndrome and paediatric inflammatory multisystem syndrome), respiratory system (lung fibrosis and pulmonary thromboembolism), cardiovascular system (cardiomyopathy and coagulopathy),
neurological system (sensory dysfunction and stroke), as well as cutaneous and gastrointestinal manifestations, impaired hepatic and renal function.
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Li, YX, Li, et al |
Chinese Journal of Integrative Medicine |
Review Literature| Revue de littérature |
SR: policy documents published since December 2019 in electronic databases (e.g., PubMed, EMBASE, and Chinese databases)
and on websites of governments or organizations (e.g., The National Guideline Clearinghouse [NGC], Guidelines International Network [GIN], National Institute for Health and Clinical Excellence (NICE), Scottish Intercollegiate Guidelines Network [SIGN], and
WHO). |
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Ling, X, Kang, et al |
Taiwan Journal of Ophthalmology |
Review Literature| Revue de littérature |
SR-MA: studies published in the period of November 1, 2019, and July 15, 2020 were included. In summary, ocular manifestations
in COVID 19 patients commonly comprise ocular surface symptoms. |
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Malik, P, Patel, et al |
Journal of medical virology |
Review Literature| Revue de littérature |
SR-MA: Data from observational studies describing the obesity or body mass index and outcomes of COVID-19 hospitalized
patients from December 1, 2019, to August 15, 2020, was extracted. Our study suggests a significant association between obesity and COVID-19 severity and poor outcomes. Our results findings may have important suggestions for the clinical management and future
research of obesity and COVID-19. |
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Manti, S, Licari, et al |
Acta Biomedica |
Review Literature| Revue de littérature |
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SARS-CoV-2 and influenza: A comparative overview and treatment implications |
Manzanares-Meza, L, Medina-Contreras, et al |
Boletin medico del Hospital Infantil de Mexico |
Review Literature| Revue de littérature |
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Possible Role for Bacteriophages in the Treatment of SARS-CoV-2 Infection |
Mishra, VN, Kumari, et al |
International Journal of Microbiology |
Review Literature| Revue de littérature |
|
|
Covid-19, from Venice to Wuhan: A historical recognition and potential
mutations of globalization |
Modaffari, G |
Documenti Geografici |
Review Literature| Revue de littérature |
|
|
Geriatric challenges in the new coronavirus disease-19 (COVID-19) pandemic: A systematic
review |
Mohamadi, M, Goodarzi, et al |
Medical Journal of the Islamic Republic of Iran |
Review Literature| Revue de littérature |
SR: Science Direct, Google Scholar, Scopus, PubMed databases were searched for published articles related to COVID-19
in the elderly up to March 26, 2020. More attention needs to be paid to elderly individuals in the quarantine. Social contact should be made and maintained through online facilities, media, and phone calls to ensure patients' mental health during this stressful
situation. |
|
COVID-19 respiratory support in the emergency department setting |
Montrief, T, Ramzy, et al |
American Journal of Emergency Medicine |
Review Literature| Revue de littérature |
|
|
Mun, DH, Pradere, et al |
BJU international |
Review Literature| Revue de littérature |
ScR: PubMed, Cochrane, the Excerpta Medica dataBASE (EMBASE), Clinical Trial Register, and the Grey Literature Repository
databases were searched. There seems to be a dissonance between contemporary guidelines and ongoing surgical activity, possibly due to the perceived lack of evidence. Recommendations regarding changes in clinical practice should be based on the best available
research evidence and experience. A scoping review of the evidence and an assessment of the benefits and harms together with a survey showed that laparoscopic procedures do not seem to increase the risk of viral transmission.
|
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Murza, A, Dion, et al |
Expert Opinion on Therapeutic Patents |
Review Literature| Revue de littérature |
|
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COVID-19 rapid diagnostic test could contain transmission in low- And middle-income
countries |
Olalekan, A, Iwalokun, et al |
African Journal of Laboratory Medicine |
Review Literature| Revue de littérature |
|
|
SARS-CoV-2 in wastewater: Challenges for developing countries |
Pandey, D, Verma, et al |
International journal of hygiene and environmental health |
Review Literature| Revue de littérature |
|
|
Coronaviruses and Australian bats: A review in the midst of a pandemic |
Peel, AJ, Field, et al |
Australian Journal of Zoology |
Review Literature| Revue de littérature |
|
|
Pei, L, Zhang, et al |
Polish Archives of Internal Medicine |
Review Literature| Revue de littérature |
SR-MA: The PubMed, Embase, Web of Science, Cochrane Library, and major preprint platforms were searched to retrieve
articles published until April 7, 2020. With the varied heterogeneities across interventions, the current evidence indicated a probable survival benefit from antiviral agent use and a harmful effect of glucocorticoids in patients with COVID-19. Neither any
of antibiotics nor intravenous immunoglobulin were associated with survival benefit in this population.
|
|
|
Title: COVID-19 and frontline health workers in West
Africa: a scoping review |
Pereko, KingsleyKA, Ameyaw, et al |
medRxiv |
Review Literature| Revue de littérature |
ScR: Cochrane Library, PubMed, EMBASE, Google Scholar, Africa Journals Online (AJOL) and CINAHL. Being the first scoping
review on the impact of COVID-19 on frontline health workers in West Africa, the study has illustrated the urgent need for West African governments to enact laws/rules that would compel all frontline health workers to adhere to all the COVID-19 protocols at
the workplace. To end intermittent shortage or issue of inadequate PPEs, governments ought to liaise with local industries by empowering them, providing financial support and creating a conducive atmosphere for them to produce cost effective PPEs using available
local resources. |
|
COVID-19 and thromboprophylaxis: Recommendations for our clinical practice in
Primary Care |
Piera Carbonell, A, Frías Vargas, et al |
Semergen |
Review Literature| Revue de littérature |
|
|
Robertson, LJ, Maposa, et al |
South African Medical Journal |
Review Literature| Revue de littérature |
ScR: PubMed, Cochrane, Web of Science and MEDLINE databases were searched for any type of evidence published in English
between 2014 and 2020. Depression, anxiety, post-traumatic stress, and other mental health conditions were noted among healthcare workers exposed to COVID-19 and other outbreaks.
|
|
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Mask etiquette amidst COVID-19 crisis and personal protection equipment shortage |
Salunke, G, Biswas, et al |
Indian Journal of Medical and Paediatric Oncology |
Review Literature| Revue de littérature |
|
|
Tocilizumab for treatment patients with COVID-19: Recommended medication for
novel disease |
Samaee, H, Mohsenzadegan, et al |
International immunopharmacology |
Review Literature| Revue de littérature |
|
|
Sanjith, S, Jothi Priya, et al |
International Journal of Pharmaceutical Research |
Review Literature| Revue de littérature |
|
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|
Vascular Events, Vascular Disease and Vascular Risk Factors—Strongly Intertwined
with COVID-19 |
Scutelnic, A, Heldner, et al |
Current Treatment Options in Neurology |
Review Literature| Revue de littérature |
|
|
Chemically Diverse and Biologically Active Secondary Metabolites from Marine Phylum chlorophyta |
Shah, SAA, Hassan, et al |
Marine drugs |
Review Literature| Revue de littérature |
|
|
A critical review of outcomes of cancer during the COVID-19 pandemic |
Sharin, F, Singh, et al |
Indian Journal of Medical and Paediatric Oncology |
Review Literature| Revue de littérature |
|
|
The current recommended drugs and strategies for the treatment of coronavirus disease
(COVID-19) |
Sheikhpour, M |
Therapeutics and Clinical Risk Management |
Review Literature| Revue de littérature |
|
|
Maternal and fetal outcomes of COVID-19, SARS, and MERS: A narrative review on
the current knowledge |
Simsek, Y, Ciplak, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
|
|
Singh, B, Gornet, et al |
American Journal of Reproductive Immunology |
Review Literature| Revue de littérature |
|
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|
Soler, M, Scholtz, et al |
APL Photonics |
Review Literature| Revue de littérature |
|
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Stavropoulou, E, Bezirtzoglou, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
|
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Sultana, J, Mazzaglia, et al |
Expert Review of Vaccines |
Review Literature| Revue de littérature |
|
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|
Tamouza, R, Krishnamoorthy, et al |
Brain, behavior, and immunity |
Review Literature| Revue de littérature |
|
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|
Tan, Elinor, Song, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
SR-MA: Medline, Embase and the Cochrane library were searched up to 1 August 2020. Critically ill patients with COVID-19
who are admitted to ICU require substantial organ support and prolonged ICU and hospital level care. The pooled estimate of global mortality for severe COVID-19 is <1/3.
|
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|
Tetteh, EK, Amankwa, et al |
Water (Switzerland) |
Review Literature| Revue de littérature |
|
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Tirupathamma, M, Niranjan, et al |
Telecommunications and Radio Engineering (English translation of Elektrosvyaz and Radiotekhnika) |
Review Literature| Revue de littérature |
|
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Tsoupras, A, Lordan, et al |
Frontiers in Nutrition |
Review Literature| Revue de littérature |
|
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How to get away with COVID-19: endoscopy during post-peak pandemic. A perspective
review |
Vanella, G, Capurso, et al |
Therapeutic Advances in Gastroenterology |
Review Literature| Revue de littérature |
|
|
Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19) |
Verma, S, Twilley, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
|
|
Systematic review of reviews of symptoms and signs
of COVID-19 in children and adolescents |
Viner, RussellM, Ward, et al |
medRxiv |
Review Literature| Revue de littérature |
SR: PubMed, medRxiv, Europe PMC and COVID-19 Living Evidence Database were searched on 9 October 2020. Fever and cough
are the most common symptoms in CYP with COVID-19, with other symptoms infrequent. |
|
Acute Ischemic Stroke in COVID-19: A Case-Based Systematic Review |
Wijeratne, T, Sales, et al |
Frontiers in Neurology |
Review Literature| Revue de littérature |
SR: Published articles in English and on human subjects that were published from November 2019 until 30th May 2020
were the inclusion criteria for the search. MEDLINE, Cochrane and CINAHL databases were searched. Higher NLR, C-Reactive protein, serum ferritin, D-dimer and fibrinogen levels are associated with poor prognosis of AIS in COVID-19 with 75% of patients dying
or being severely disabled at present. |
|
Xia, Y, Zhong, et al |
Frontiers in Cell and Developmental Biology |
Review Literature| Revue de littérature |
|
|
|
Yuan, L, Chen, et al |
Stroke and vascular neurology |
Review Literature| Revue de littérature |
|
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Zarbafian, M, Dayan, et al |
Journal of Cosmetic Dermatology |
Review Literature| Revue de littérature |
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Supporting school teachers’ rapid engagement with online education |
Abaci, S, Robertson, et al |
Educational Technology Research and Development |
Commentary/Editorial| Commentaire/Éditorial |
|
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Choosing awareness over fear: Risk analysis and free trade support global food security |
Adamchick, J, Perez, et al |
Global Food Security |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Adiukwu, F, Orsolini, et al |
General Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Willingness to comply with physical distancing measures against COVID-19 in four
African countries |
Ag Ahmed, MA, Ly, et al |
BMJ Global Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ahrens, T, Ferry, et al |
Public Money and Management |
Commentary/Editorial| Commentaire/Éditorial |
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Safety of nontumor necrosis factor-targeted biologics in the COVID-19 pandemic |
Akiyama, S, Yamada, et al |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Perspective: The Potential Effects of Naringenin in COVID-19 |
Alberca, RW, Teixeira, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Iraq faces the COVID-19 with limited health capabilities and major medical challenges |
Al-Dahhan, W, Al-Mashhadani, et al |
Revista Bionatura |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 and symbolic action: global pandemic as code, narrative, and cultural
performance |
Alexander, JC, Smith, et al |
American Journal of Cultural Sociology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Alicia, M, Cavada, et al |
Revista medica de Chile |
Commentary/Editorial| Commentaire/Éditorial |
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Allchin, D |
American Biology Teacher |
Commentary/Editorial| Commentaire/Éditorial |
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Alrubayyi, A |
Nature Reviews Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Altshuler, E, Zeldin, et al |
Journal of Mental Health Research in Intellectual Disabilities |
Commentary/Editorial| Commentaire/Éditorial |
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Amann, ÁM |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
|
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Anderson, M |
IEEE Spectrum |
Commentary/Editorial| Commentaire/Éditorial |
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Andrade, A |
Revista Brasileira de Neurologia e Psiquiatria |
Commentary/Editorial| Commentaire/Éditorial |
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Reduction in skin cancer diagnoses in the UK during the COVID-19 pandemic |
Andrew, TW, Alrawi, et al |
Clinical and experimental dermatology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Arango, VM |
Geopolitica(s) |
Commentary/Editorial| Commentaire/Éditorial |
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Using the curriculum vitae to promote gender equity during the COVID-19 pandemic |
Arora, VM, Wray, et al |
Proceedings of the National Academy of Sciences of the United States of America |
Commentary/Editorial| Commentaire/Éditorial |
|
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Arshid, MA, Mumtaz, et al |
Arab Journal of Basic and Applied Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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The effects of the COVID pandemic on the federal budget outlook |
Auerbach, AJ, Gale, et al |
Business Economics |
Commentary/Editorial| Commentaire/Éditorial |
|
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Perspectives for the future in Italy: Animal science higher education, employment, and
research |
Baldi, A, Macciotta, et al |
Animal Frontiers |
Commentary/Editorial| Commentaire/Éditorial |
|
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Balduccini, M, Barborak, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
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Solving the climate crisis: Lessons from ozone depletion and COVID-19 |
Baldwin, MP, Lenton, et al |
Global Sustainability |
Commentary/Editorial| Commentaire/Éditorial |
|
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Basit, A |
Journal of Policing, Intelligence and Counter Terrorism |
Commentary/Editorial| Commentaire/Éditorial |
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Battin, J |
Bulletin de l'Academie nationale de medecine |
Commentary/Editorial| Commentaire/Éditorial |
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Baxi, U |
Business and Human Rights Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Bechtold, A |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
|
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Beech, N, Anseel, et al |
British Journal of Management |
Commentary/Editorial| Commentaire/Éditorial |
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The cytokine storm—An appropriate, over-reactive response to SARS-CoV-2 or the wrong immune
pathway? |
Bellgrau, D, Modiano, et al |
Scandinavian Journal of Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Reasoning
on company takeovers during the COVID-19 crisis with knowledge graphs |
Bellomarini, L, Benedetti, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
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Benaderette, S |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
|
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Benkeser, D, Díaz, et al |
Biometrics |
Commentary/Editorial| Commentaire/Éditorial |
|
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Urbanizzazione planetaria e Covid-19: Nuove geografie per convivere con
la natura? |
Bertocci, L, Panosetti, et al |
Documenti Geografici |
Commentary/Editorial| Commentaire/Éditorial |
|
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Laboratory biosafety issues related to coronavirus disease 2019 |
Bhat, V, Chavan, et al |
Indian Journal of Medical and Paediatric Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
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A Rapidly Deployable Test Suite for Respiratory Protective Devices in the COVID-19
Pandemic |
Blad, T, Nijssen, et al |
Applied Biosafety |
Commentary/Editorial| Commentaire/Éditorial |
|
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Frontline Nursing Care: The COVID-19 Pandemic and the Brazilian Health System |
Bolina, AF, Bomfim, et al |
SAGE Open Nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
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Bonadias Gadelha, A, Lima, et al |
The Journal of frailty & aging |
Commentary/Editorial| Commentaire/Éditorial |
|
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Bonn, M, Palayew, et al |
Journal of Studies on Alcohol and Drugs |
Commentary/Editorial| Commentaire/Éditorial |
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Insights from early COVID-19 responses about promoting sustainable action |
Bouman, T, Steg, et al |
Nature Sustainability |
Commentary/Editorial| Commentaire/Éditorial |
|
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Beyond (Mis)Representation: Visuals in COVID-19 Misinformation |
Brennen, JS, Simon, et al |
International Journal of Press/Politics |
Commentary/Editorial| Commentaire/Éditorial |
|
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Potential interventions for SARS-CoV-2 infections: Zinc showing promise |
Brewer, J, Gomez Marti, et al |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Browne, T, Grandinetti, et al |
American Journal of Transplantation |
Commentary/Editorial| Commentaire/Éditorial |
|
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Buchwald, AG, Adams, et al |
Annals of the American Thoracic Society |
Commentary/Editorial| Commentaire/Éditorial |
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Dengue fever and COVID-19 coinfection; a threat to public health for coepidemic in Pakistan |
Butt, MH, Ahmad, et al |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Calboli, I |
Journal of Intellectual Property Law and Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
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Dramatic presentation of acquired thrombotic thrombocytopenic purpura associated
with COVID-19 |
Capecchi, M, Mocellin, et al |
Haematologica |
Commentary/Editorial| Commentaire/Éditorial |
|
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Capps, B |
Cambridge Quarterly of Healthcare Ethics |
Commentary/Editorial| Commentaire/Éditorial |
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Carneiro-Leão, L, Amaral, et al |
Revista Portuguesa de Imunoalergologia |
Commentary/Editorial| Commentaire/Éditorial |
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Let a thousand analog oscillators sing: Sam Battle, champion of analog engineering-[Geek
Life] |
Cass, S |
IEEE Spectrum |
Commentary/Editorial| Commentaire/Éditorial |
|
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Castelnuovo, G, De Giorgio, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Casula, M |
Documenti Geografici |
Commentary/Editorial| Commentaire/Éditorial |
|
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Celis-Morales, C, Salas-Bravo, et al |
Revista medica de Chile |
Commentary/Editorial| Commentaire/Éditorial |
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Accommodation facilities for dependent elderly people facing the pandemic |
Chagué, V |
Actualites Pharmaceutiques |
Commentary/Editorial| Commentaire/Éditorial |
|
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Chang, JH, Diop, et al |
Clinical transplantation |
Commentary/Editorial| Commentaire/Éditorial |
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Containing coronavirus (COVID-19) spread in an oncology day care facility in India |
Chellapuram, S, Malik, et al |
Indian Journal of Medical and Paediatric Oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Choucair, F, Younis, et al |
Middle East Fertility Society Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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This food crisis is different: COVID-19 and the fragility of the neoliberal
food security order |
Clapp, J, Moseley, et al |
Journal of Peasant Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
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Contreras, M |
Revista medica de Chile |
Commentary/Editorial| Commentaire/Éditorial |
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Cossiga, AM |
Documenti Geografici |
Commentary/Editorial| Commentaire/Éditorial |
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Healthcare Workers in Brazil during the COVID-19 Pandemic: A Cross-Sectional Online
Survey |
Cotrin, P, Moura, et al |
Inquiry (United States) |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 in long-term care facilities in South Africa: No time for complacency |
Cowper, B, Jassat, et al |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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World wide closed! Social worker field practice during the ‘lockdown’ period |
Csoba, J, Diebel, et al |
Social Work Education |
Commentary/Editorial| Commentaire/Éditorial |
|
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Study of critically ill patients with COVID-19 in New York City – Authors' reply |
Cummings, MJ, O'Donnell, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
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Dalmat, YM |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
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Dalmat, YM |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
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Dalmat, YM |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
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Bréve: Covid-19: revalorisation de la visite à domicile SOS
Médecins |
Dalmat, YM |
Option/Bio |
Commentary/Editorial| Commentaire/Éditorial |
|
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Dao, K, Chun, et al |
Graziadio Business Review |
Commentary/Editorial| Commentaire/Éditorial |
|
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Davies, K |
Clinical Teacher |
Commentary/Editorial| Commentaire/Éditorial |
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de Bilbao, GM |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
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de Bilbao, GM |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
|
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Las enfermeras y enfermeros
de Bizkaia, en la vanguardia sanitaria frente a la COVID-19 |
de Bilbao, GM |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19ri
buruzko gogoetak Fisioterapiatik Thoughts about COVID-19 from Physiotherapy |
de Bilbao, GM, Soto, et al |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
|
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Personal account of remote teaching for tertiary education in a South African context |
De Villiers Bosman, I |
Education for Information |
Commentary/Editorial| Commentaire/Éditorial |
|
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de Vincenzo, D |
Documenti Geografici |
Commentary/Editorial| Commentaire/Éditorial |
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Delrahim, M |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
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Dhanushkodi, M, Kulkarni, et al |
Indian Journal of Medical and Paediatric Oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Di Giacomo, MGG, de Felice, et al |
Documenti Geografici |
Commentary/Editorial| Commentaire/Éditorial |
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Díaz, RT, Eduardo Lorca, et al |
Revista medica de Chile |
Commentary/Editorial| Commentaire/Éditorial |
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DiBenigno, J, Kerrissey, et al |
BMJ Leader |
Commentary/Editorial| Commentaire/Éditorial |
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Diener, HC |
Arzneimitteltherapie |
Commentary/Editorial| Commentaire/Éditorial |
|
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A Suggested Approach for Management of Pediatric Asthma During the COVID-19 Pandemic |
Ding, B, Lu, et al |
Frontiers in Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
|
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Doupis, J, Avramidis, et al |
European Endocrinology |
Commentary/Editorial| Commentaire/Éditorial |
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Human herpesvirus-6, -7, and Epstein-Barr virus reactivation in pityriasis rosea during
COVID-19 |
Drago, F, Ciccarese, et al |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
|
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ELSI Implications of Prioritizing Biological Therapies in Times of COVID-19 |
Druedahl, LC, Lebret, et al |
Journal of Law, Medicine and Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
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E Côrte, , ACR, et al |
Revista Brasileira de Medicina do Esporte |
Commentary/Editorial| Commentaire/Éditorial |
|
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BRACE-CORONA
trial - COVID-19: No severe course in patients undergoing RAS inhibition |
Eckert, N |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
|
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Managing dental caries against the backdrop of COVID-19: approaches to reduce aerosol
generation |
Eden, E, Frencken, et al |
British dental journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Diabetes mellitus and COVID-19: Factors associated with bad prognosis |
El Guendouz, F |
Clinical Diabetology |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 specialized diabetes clinic model for excellence in diabetes Care: Scientific
perspective |
El-Malky, A, Alsaqabi, et al |
Clinical Diabetology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ely, J |
Nursing Older People |
Commentary/Editorial| Commentaire/Éditorial |
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Espín, E |
Revista Bionatura |
Commentary/Editorial| Commentaire/Éditorial |
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Etzioni, A |
The Journal of clinical ethics |
Commentary/Editorial| Commentaire/Éditorial |
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Falkenhain, M, Flick, et al |
European Societies |
Commentary/Editorial| Commentaire/Éditorial |
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Safe ports: Law, theory, practice under conditions of the COVID-19 pandemic |
Faqiang, L, Abliakimova, et al |
Lex Portus |
Commentary/Editorial| Commentaire/Éditorial |
|
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Farhangrazi, ZS, Sancini, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Role of the chronic air pollution levels in the Covid-19 outbreak risk in Italy |
Fattorini, D, Regoli, et al |
Environmental Pollution |
Commentary/Editorial| Commentaire/Éditorial |
|
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Problematizing the Global: An Introduction to Global Culture Revisited |
Featherstone, M |
Theory, Culture and Society |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations for performing interventions during the COVID-19 pandemic |
Fernández-Bussy, S, Sánchez, et al |
Revista medica de Chile |
Commentary/Editorial| Commentaire/Éditorial |
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Working with open data in times of pandemics: Using covidDATA-19 |
Ferrer-Sapena, A, Calabuig, et al |
Profesional de la Informacion |
Commentary/Editorial| Commentaire/Éditorial |
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Flannery, T, Bladen, et al |
Haemophilia |
Commentary/Editorial| Commentaire/Éditorial |
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Introduction to the Ophthalmologists-in-Training COVID-19 Editorials |
Folberg, R, Higginbotham, et al |
American Journal of Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
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French, M, Guta, et al |
Critical Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Fu, YK |
Cogent Social Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Gao, F, Deng, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Garcia, M, Lipskiy, et al |
Journal of the American Medical Informatics Association : JAMIA |
Commentary/Editorial| Commentaire/Éditorial |
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Gea-Mallorquí, E |
Nature Reviews Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Gianotti, R |
Dermatology Reports |
Commentary/Editorial| Commentaire/Éditorial |
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History of the Plague: An Ancient Pandemic for the Age of COVID-19 |
Glatter, KA, Finkelman, et al |
American Journal of Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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How the irish competition and consumer protection commission is responding to the COVID-19
challenge |
Goggin, I |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
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Telemedicine and cancer research during the COVID-19 pandemic |
Gonçalves, BT, Baiocchi, et al |
Journal of surgical oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Facilitating Access to a COVID-19 Vaccine through Global Health Law |
Gostin, LO, Karim, et al |
Journal of Law, Medicine and Ethics |
Commentary/Editorial| Commentaire/Éditorial |
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Goyens, M, Reyna, et al |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
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The Regulatory Challenges for Drug Repurposing During the Covid-19 Pandemic: The
Italian Experience |
Gozzo, L, Longo, et al |
Frontiers in Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Hysteresis and the sociological perspective in a time of crisis |
Graham, H |
Acta Sociologica (United Kingdom) |
Commentary/Editorial| Commentaire/Éditorial |
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Have we learnt anything from COVID-19, and can we put it to good use in the
future? |
Green, RJ, Mustafa, et al |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Greene, FJ, Rosiello, et al |
International Small Business Journal: Researching Entrepreneurship |
Commentary/Editorial| Commentaire/Éditorial |
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Noninvasive ventilation and risk of infection:
Aerosols from COVID-19 patients |
Grensemann, J, Kluge, et al |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Undermining breastfeeding will not alleviate the COVID-19 pandemic – Authors'
reply |
Groß, R, Conzelmann, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Gupta, S, Raghuwanshi, et al |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
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Gusenbauer, M, Haddaway, et al |
Research Synthesis Methods |
Commentary/Editorial| Commentaire/Éditorial |
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Haas, BW, Hoeft, et al |
Personality and Individual Differences |
Commentary/Editorial| Commentaire/Éditorial |
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Treatment of multiple sclerosis during the covid-19 pandemic |
Habek, M |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Halbwax, M |
Biological Conservation |
Commentary/Editorial| Commentaire/Éditorial |
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Hanlin, H, Holmes, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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College student registration and voting in the time of COVID-19 |
Hanmer, MJ, Niemi, et al |
Election Law Journal: Rules, Politics, and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Haque, S, Jawed, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Hasan, MR, Mirza, et al |
PLoS ONE |
Commentary/Editorial| Commentaire/Éditorial |
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Hasen, RL |
Election Law Journal: Rules, Politics, and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Hayter, W |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
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Heimler, A |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
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Hekmat, M, Ghaderi, et al |
Journal of Cellular and Molecular Anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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When Paid Work Invades the Family: Single Mothers in the COVID-19 Pandemic |
Hertz, R, Mattes, et al |
Journal of Family Issues |
Commentary/Editorial| Commentaire/Éditorial |
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Legal “Tug-of-Wars” During the COVID-19 Pandemic: Public Health v. Economic Prosperity |
Hodge, JG, J, et al |
Journal of Law, Medicine and Ethics |
Commentary/Editorial| Commentaire/Éditorial |
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Hoehner, P, Beyda, et al |
Christian Journal for Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Hoffer-Hawlik, M, Moran, et al |
Global Heart |
Commentary/Editorial| Commentaire/Éditorial |
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Holme, TA |
Journal of chemical education |
Commentary/Editorial| Commentaire/Éditorial |
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The SARS-CoV-2 'perfect storm': From humble betacoronavirus to global pandemic |
Howard-Jones, A, Kok, et al |
Microbiology Australia |
Commentary/Editorial| Commentaire/Éditorial |
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The Dilemma of contacttracing apps: Can this crucial technology be both effective
and private? |
Hsu, J |
IEEE Spectrum |
Commentary/Editorial| Commentaire/Éditorial |
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Huang, L |
Journal of Hospital Librarianship |
Commentary/Editorial| Commentaire/Éditorial |
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Hutson, M |
IEEE Spectrum |
Commentary/Editorial| Commentaire/Éditorial |
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Iannello, D |
Documenti Geografici |
Commentary/Editorial| Commentaire/Éditorial |
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Irons, JF, Pavey, et al |
Medical Journal of Australia |
Commentary/Editorial| Commentaire/Éditorial |
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Midst of COVID-19 crisis - Lookout for one another to practice humanity! |
Jain, R, Pathak, et al |
Indian Journal of Medical and Paediatric Oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Jain, SK, Parsanathan, et al |
Free Radical Biology and Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Janover, W, Westphal, et al |
Election Law Journal: Rules, Politics, and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Jha, D, Sharma, et al |
Biochemical and Cellular Archives |
Commentary/Editorial| Commentaire/Éditorial |
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Jones, A |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
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Myopericarditis and skin rash in a patient with COVID-19 infection |
Jorge, AR, Jhenina, et al |
Revista Bionatura |
Commentary/Editorial| Commentaire/Éditorial |
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Kalin, NH |
American Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Kalra, S, Bhattacharya, et al |
European Endocrinology |
Commentary/Editorial| Commentaire/Éditorial |
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Kazandjian, VA |
International Journal of Reliable and Quality E-Healthcare |
Commentary/Editorial| Commentaire/Éditorial |
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Kedia, S, Pandey, et al |
Millennial Asia |
Commentary/Editorial| Commentaire/Éditorial |
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Kerr, A, Shuker, et al |
The New Zealand medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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Considerations about cognitive communication deficits following COVID-19 |
Khatoonabadi, AR, Joanette, et al |
Psychiatry and clinical neurosciences |
Commentary/Editorial| Commentaire/Éditorial |
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Khayale, C, Kariuki, et al |
Pachyderm |
Commentary/Editorial| Commentaire/Éditorial |
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Kibuuka, BGL |
International Journal of Latin American Religions |
Commentary/Editorial| Commentaire/Éditorial |
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Kidane, B, Spicer, et al |
Frontiers in Oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Killeit, U |
Deutsche Lebensmittel-Rundschau |
Commentary/Editorial| Commentaire/Éditorial |
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Killeit, U |
Deutsche Lebensmittel-Rundschau |
Commentary/Editorial| Commentaire/Éditorial |
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Kim, T, Fu, et al |
Asia Pacific Journal of Social Work and Development |
Commentary/Editorial| Commentaire/Éditorial |
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Non-tariff barriers: Ukrainian practice under conflict with russia and covid-19 |
Koval, N, Luchenko, et al |
Lex Portus |
Commentary/Editorial| Commentaire/Éditorial |
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Educating deaf and hard-of-hearing students during COVID-19: What parents
need to know |
Kritzer, KL, Smith, et al |
Hearing Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Kuderer, NM, Wulff-Burchfield, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Kumanan, T, Rajasooriyar, et al |
Asia-Pacific Journal of Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Kumar, P, Huda, et al |
European Surgery - Acta Chirurgica Austriaca |
Commentary/Editorial| Commentaire/Éditorial |
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Lai, J, Widmar, et al |
Applied Economic Perspectives and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Pandemic Politics in Eurasia: Roadmap for a New Research Subfield |
Laruelle, M, Alexseev, et al |
Problems of Post-Communism |
Commentary/Editorial| Commentaire/Éditorial |
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Le Maréchal, M, Morand, et al |
Medecine et Maladies Infectieuses |
Commentary/Editorial| Commentaire/Éditorial |
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Lost in Translation: The Role of Interpreters on Labor and Delivery |
Le Neveu, M, Berger, et al |
Health Equity |
Commentary/Editorial| Commentaire/Éditorial |
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Lembke, A |
Journal of Studies on Alcohol and Drugs |
Commentary/Editorial| Commentaire/Éditorial |
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Leone, U |
Documenti Geografici |
Commentary/Editorial| Commentaire/Éditorial |
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Long, R, King, et al |
EClinicalMedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Anticoagulation in COVID-19: It Is Time for High-Quality Evidence |
Lopes, RD, Fanaroff, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Letter to the editor regarding supplement 1, 2020 on the SARS-CoV-2 pandemic |
Loredo-Abdalá, A, Galván-Díaz, et al |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Lotova, GZ, Mikhailov, et al |
Journal of Inverse and Ill-Posed Problems |
Commentary/Editorial| Commentaire/Éditorial |
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Adjuvant corticosteroid therapy for critically ill
patients with COVID-19 |
Lu, X, Chen, et al |
Crit Care |
Commentary/Editorial| Commentaire/Éditorial |
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Lucas, J |
Canadian Journal of Political Science |
Commentary/Editorial| Commentaire/Éditorial |
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Conflict and COVID-19: A double burden for Afghanistan's healthcare system |
Lucero-Prisno, D, Essar, et al |
Conflict and Health |
Commentary/Editorial| Commentaire/Éditorial |
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Lyons, VH, Haviland, et al |
Injury Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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Outbreaks of COVID-19 infection in aged care facilities in Japan |
Maeda, K |
Geriatrics and Gerontology International |
Commentary/Editorial| Commentaire/Éditorial |
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Mahieu, R, Dubée, et al |
Actualites Pharmaceutiques |
Commentary/Editorial| Commentaire/Éditorial |
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Malhotra, C, Chaudhry, et al |
Proceedings of Singapore Healthcare |
Commentary/Editorial| Commentaire/Éditorial |
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The psychosocial fuzziness of fear in the coronavirus (COVID-19) era and the role
of robots |
Marchetti, A, Di Dio, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Mardones, L |
Revista medica de Chile |
Commentary/Editorial| Commentaire/Éditorial |
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Maric, F, Nicholls, et al |
European Journal of Physiotherapy |
Commentary/Editorial| Commentaire/Éditorial |
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Markus, B, Kreutz, et al |
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System |
Commentary/Editorial| Commentaire/Éditorial |
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Reflexiones para la reorganización de residencias en el contexto
de la pandemia por COVID-19 |
Martínez, LM, Perpiñá, et al |
FMC Formacion Medica Continuada en Atencion Primaria |
Commentary/Editorial| Commentaire/Éditorial |
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Martz, L |
Women's History Review |
Commentary/Editorial| Commentaire/Éditorial |
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Maslennikov, AO |
World Economy and International Relations |
Commentary/Editorial| Commentaire/Éditorial |
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Max Andresen, H, Born, et al |
Revista medica de Chile |
Commentary/Editorial| Commentaire/Éditorial |
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McQuoid-Mason, D |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Médica de Bilbao, G |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
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Medina-Mora, M, Cordero-Oropeza, et al |
Drug and Alcohol Review |
Commentary/Editorial| Commentaire/Éditorial |
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Meijer, A, Webster, et al |
Information Polity |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: Reduction of airborne transmission needs paradigm shift in ventilation |
Melikov, AK |
Building and Environment |
Commentary/Editorial| Commentaire/Éditorial |
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Mellins, CA, Mayer, et al |
General hospital psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Mendelson, M, Boloko, et al |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Mendelson, M, Booyens, et al |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Mercadante, S, Giuliana, et al |
BMJ Supportive and Palliative Care |
Commentary/Editorial| Commentaire/Éditorial |
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Merchant, RA |
The Journal of frailty & aging |
Commentary/Editorial| Commentaire/Éditorial |
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Merry, SN, Cargo, et al |
Child and Adolescent Mental Health |
Commentary/Editorial| Commentaire/Éditorial |
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Meruelo-Conde, A |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
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Messent, P |
Journal of Family Therapy |
Commentary/Editorial| Commentaire/Éditorial |
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The 5 Mʼs and More: A New Geriatric Medical Student Virtual Curriculum During the COVID-19
Pandemic |
Michener, A, Fessler, et al |
Journal of the American Geriatrics Society |
Commentary/Editorial| Commentaire/Éditorial |
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Miller, JJ |
Psychiatric Times |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and emergency care for adults experiencing homelessness |
Miller, JP, Phillips, et al |
EMA - Emergency Medicine Australasia |
Commentary/Editorial| Commentaire/Éditorial |
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Mo, GH, Wang, et al |
BioPsychoSocial Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Mokuda, S, Tokunaga, et al |
Journal of Rheumatology |
Commentary/Editorial| Commentaire/Éditorial |
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Moumtzoglou, AS |
International Journal of Reliable and Quality E-Healthcare |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2: Viral mechanisms and possible therapeutic targets — what to learn from rheumatologists |
Moura, CA, Moura, et al |
Journal of Rheumatology |
Commentary/Editorial| Commentaire/Éditorial |
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Mundt, A |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
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|
South African health professionals’ state of wellbeing during the emergence
of COVID-19 |
Naidoo, I, Mabaso, et al |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Home monitoring for patients with ILD and the COVID-19 pandemic |
Nakshbandi, G, Moor, et al |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Audiology amid COVID-19: Reopening and infection control strategies |
Nalley, C |
Hearing Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Response to Letter Regarding “A Case Series of Patients Coinfected With Influenza
and COVID-19” |
Naramala, S, Konala, et al |
Journal of Investigative Medicine High Impact Case Reports |
Commentary/Editorial| Commentaire/Éditorial |
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Interaction of corporate structures in the EU: Impact of digitalization |
Nevskaya, AA |
World Economy and International Relations |
Commentary/Editorial| Commentaire/Éditorial |
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Ng, QX, Liew, et al |
Quantitative Imaging in Medicine and Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Nimish, AM, Jaishri, et al |
Neuro-oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Competition law in times of crisis-tackling the COVID-19 challenge: A producer perspective |
Noble, J |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Novelli, V, Cutti, et al |
Acta Biomedica |
Commentary/Editorial| Commentaire/Éditorial |
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O’Neill, R |
New Solutions |
Commentary/Editorial| Commentaire/Éditorial |
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Odendaal, N |
Urban Geography |
Commentary/Editorial| Commentaire/Éditorial |
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Clinical Commentary on an Auricular Marker Associated with COVID-19 |
Oleson, T, Niemtzow, et al |
Medical Acupuncture |
Commentary/Editorial| Commentaire/Éditorial |
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Ong, S |
New Scientist |
Commentary/Editorial| Commentaire/Éditorial |
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Violations of independence: ethnicity and COVID-19 in Brazil |
Oreskovic, Tin |
The Lancet Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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The 2020 Pandemic: Economic repercussions and policy responses |
Orlowski, LT |
Review of Financial Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Ormazabal, JIG |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
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The dangers of allowing greater coordination between competitors during the COVID-19
crisis |
Ormosi, P, Stephan, et al |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
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Otaka, T, Ichikawa, et al |
Dokkyo Journal of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Otugo, O, Wages, et al |
Health Equity |
Commentary/Editorial| Commentaire/Éditorial |
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Ou, S, He, et al |
Nature Energy |
Commentary/Editorial| Commentaire/Éditorial |
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|
Padilla, J |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
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Assessing the fear of COVID-19 among different populations: A response to Ransing
et al. (2020) |
Pakpour, AH, Griffiths, et al |
Brain, behavior, and immunity |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Palagiano, C |
Documenti Geografici |
Commentary/Editorial| Commentaire/Éditorial |
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|
|
Palmer, S |
Current Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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Pan, L, Zeng, et al |
Clinical imaging |
Commentary/Editorial| Commentaire/Éditorial |
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Do saline water gargling and nasal irrigation confer protection against COVID-19? |
Panta, P, Chatti, et al |
Explore |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Multisystem inflammatory syndrome in adult COVID-19 patients |
Parker, A, Louw, et al |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pearce, L |
Nursing Older People |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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Anxiety, depression and sleep problems: A second wave of COVID-19 |
Peretti-Watel, P, Alleaume, et al |
General Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Peto, Julian, Hunter, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Towards accurate genotype–phenotype correlations in the cyp2d6 gene |
Pey, AL |
Journal of Personalized Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Pierri, MD, Alfonsi, et al |
Journal of cardiac surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Pies, RW |
Psychiatric Times |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus Historical Perspective, Disease Mechanisms, and Clinical Outcomes:
JACC Focus Seminar |
Pinney, SP, Giustino, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Covigie, a platform for caregivers and care team coordinators |
Piraux, A, Mosnier, et al |
Actualites Pharmaceutiques |
Commentary/Editorial| Commentaire/Éditorial |
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|
Preskorn, SH |
Psychiatric Times |
Commentary/Editorial| Commentaire/Éditorial |
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|
Pretz, K |
IEEE Spectrum |
Commentary/Editorial| Commentaire/Éditorial |
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|
Primdahl, NL, Borsch, et al |
Vulnerable Children and Youth Studies |
Commentary/Editorial| Commentaire/Éditorial |
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|
|
Challenges in women with diabetes during the COVID-19 pandemic |
Priya, G, Bajaj, et al |
European Endocrinology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Priyambada, L, Wolfsdorf, et al |
Pediatric Diabetes |
Commentary/Editorial| Commentaire/Éditorial |
|
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Sustainability of ASEAN integration, competition policy, and the challenges of COVID-19 |
Qaqaya, H |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
|
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Radcliffe, JS, Aaron, et al |
Animal Frontiers |
Commentary/Editorial| Commentaire/Éditorial |
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Rajender Reddy, K |
Gastroenterology and Hepatology |
Commentary/Editorial| Commentaire/Éditorial |
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Ralli, M, Candelori, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Global Pandemic: Options for Management of Gynecologic Cancers |
Ramirez, PT, Chiva, et al |
Obstetrical and Gynecological Survey |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Cocirculation of COVID-19 and dengue: A perspective from Pakistan |
Rana, MS, Alam, et al |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rastogi, R, Saxena, et al |
International Journal of Reliable and Quality E-Healthcare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Addressing excessive pricing concerns in time of the COVID-19 pandemic-a view from
South Africa |
Ratshisusu, H, Mncube, et al |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ravindra, A, Cuff, et al |
BMJ Open Sport and Exercise Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Reddy, GB, Greif, et al |
HSS Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Respectful maternity care in the context of COVID-19: A human rights perspective |
Reingold, RB, Barbosa, et al |
International Journal of Gynecology and Obstetrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Reynolds, JA, Cai, et al |
Ecology and Evolution |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Richter, FC |
Nature Reviews Immunology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Changing route: Common action on food systems transformation in the mediterranean |
Ridolfi, R, Dernini, et al |
New Medit |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Riva, G, Bernardelli, et al |
Frontiers in Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Rodríguez-Jurado, R |
Acta Pediatrica de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
|
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Rohde, C, Hougaard Jefsen, et al |
Acta Neuropsychiatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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About heroes, enemies, victims and battles in the COVID-19 era |
Rojas, D, Micolich, et al |
Revista medica de Chile |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Roy, L |
Reference Librarian |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Ruiz, AM |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
In the smaller world of Covid-19, we shall come back to Geography |
Rumiz, P |
Documenti Geografici |
Commentary/Editorial| Commentaire/Éditorial |
|
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IT responses to Covid-19: rapid innovation and strategic resilience in healthcare |
Rusinko, C |
Information Systems Management |
Commentary/Editorial| Commentaire/Éditorial |
|
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Evaluating patients' decision-making capacity during COVID-19 |
Ryznar, E |
Current Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Sabas Olabarria, JL, de Bilbao, et al |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sager, F, Mavrot, et al |
European Policy Analysis |
Commentary/Editorial| Commentaire/Éditorial |
|
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Samuel, RD, Tenenbaum, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Sandhaus, H, Crosby, et al |
Otolaryngology - Head and Neck Surgery (United States) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Santangelo, S |
Documenti Geografici |
Commentary/Editorial| Commentaire/Éditorial |
|
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The financial and employment effects of coronavirus disease 2019 on physicians in
the United States |
Satiani, B, Davis, et al |
Journal of Vascular Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
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Schiariti, M, Restelli, et al |
Journal of neurosurgery |
Commentary/Editorial| Commentaire/Éditorial |
|
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Why Covid-19 represents the worst enemy on the Franci's road |
Schiavazzi, P |
Documenti Geografici |
Commentary/Editorial| Commentaire/Éditorial |
|
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Schütze, B |
Deutsche Lebensmittel-Rundschau |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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Scudellari, M |
IEEE Spectrum |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19: Molecular targets, drug repurposing and new avenues for drug discovery |
Senger, MR, Evangelista, et al |
Memorias do Instituto Oswaldo Cruz |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The importance
of digital marketing in hospitality: Case study of hotel turismo são lázaro |
Serra, D, Morais, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
|
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Shanmugam, R |
Journal of Healthcare Informatics Research |
Commentary/Editorial| Commentaire/Éditorial |
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Sharma, NK, Sarode, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Shen, J, Bartram, et al |
European Societies |
Commentary/Editorial| Commentaire/Éditorial |
|
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Shiple, C, Eamranond, et al |
Journal of forensic sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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Siew, ED, Birkelo, et al |
Clinical Journal of the American Society of Nephrology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Sim, AJ, Redler, et al |
Cancer Control |
Commentary/Editorial| Commentaire/Éditorial |
|
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The federal trade commission's response to the COVID-19 pandemic |
Simons, JJ |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sims, R |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Home based ventilator support during COVID-19 pandemic: A double-edged sword |
Singh, A, Khanna, et al |
Journal of Cellular and Molecular Anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Striking a balance between principle and pragmatism in COVID-19-related enforcement
in Hong Kong |
Snyder, B |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Söderström, O |
Urban Geography |
Commentary/Editorial| Commentaire/Éditorial |
|
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Spuur, KM |
Journal of Medical Radiation Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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Disjunctive Globalization in the Era of the Great Unsettling |
Steger, M, James, et al |
Theory, Culture and Society |
Commentary/Editorial| Commentaire/Éditorial |
|
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Stokol, T, McAloose, et al |
Frontiers in Veterinary Science |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 has taught US that foresight and tech are a winning combination |
Strickland, E, Zorpette, et al |
IEEE Spectrum |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 and competition-aspiring for more than our old normality? |
Stucke, ME, Ezrachi, et al |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
|
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A global effort to understand the riddles of COVID-19 and cancer |
Subbiah, V |
Nature Cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
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Sun, W, Gao, et al |
Frontiers in Microbiology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Implementing U.S. Covid-19 Testing: Regulatory and Infrastructural Challenges |
Tan, YT, Kesselheim, et al |
Journal of Law, Medicine and Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
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Tempero, M |
JNCCN Journal of the National Comprehensive Cancer Network |
Commentary/Editorial| Commentaire/Éditorial |
|
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The Lancet Public, Health |
The Lancet Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Thomas, T, Laher, et al |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Turnquist, C, Ryan, et al |
Cancer Cell |
Commentary/Editorial| Commentaire/Éditorial |
|
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Usher, K, Ranmuthugala, et al |
International Journal of Mental Health Nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
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V P, S, Rai, et al |
Journal of Stroke and Cerebrovascular Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
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Valencia Portillo, RT, Uscata, et al |
Revista Bionatura |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
van Dam, LF, Kroft, et al |
Thrombosis research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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Applications of Internet of Things (IoT) to Track COVID-19 in Real Time |
Vangeti, Madhuri, Wata Dereso, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Verger, P, Dubé, et al |
Expert Review of Vaccines |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Verma, A, Kumar, et al |
Kathmandu University Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Volf, N, Salques, et al |
Medical Acupuncture |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wahlqvist, ML |
Asia Pacific Journal of Clinical Nutrition |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wakui, M |
Journal of Antitrust Enforcement |
Commentary/Editorial| Commentaire/Éditorial |
|
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AI takes its best shot: What AI can-and can't-do in the race for a coronavirus
vaccine-[Vaccine] |
Waltz, E |
IEEE Spectrum |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wang, J, Du, et al |
Ir J Med Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
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Weisbrot, DM, Ryst, et al |
Child and Adolescent Mental Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Preparing for COVID-19: The lessons from SARS 2003 in Canada |
White, D |
Asia Pacific Family Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wilk, AaronJ, Rustagi, et al |
bioRxiv |
Commentary/Editorial| Commentaire/Éditorial |
|
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Optimizing communication in schools and other settings during COVID-19 |
Wolfe, J, Smith, et al |
Hearing Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Worrall, AP, Kelly, et al |
European journal of haematology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Xiong, R, Zhang, et al |
Protein and Cell |
Commentary/Editorial| Commentaire/Éditorial |
|
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Yadav, UN, Rayamajhee, et al |
Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yan, W, Schneider, et al |
IEEE Spectrum |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cloud-based Livestock Monitoring System Using RFID and Blockchain
Technology |
Yang, L, Liu, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
|
Yari, Imrana Abdullahi, Dehling, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Vox Sanguinis International Forum on Hospital Transfusion Services' Response to COVID-19:
Responses |
Yazer, MH, Jackson, et al |
Vox sanguinis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zhu, S, Li, et al |
Asia Pacific Family Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Effective treatment of severe acute pancreatitis and COVID-19 pneumonia with tocilizumab |
Zielecki, P, Kaniewska, et al |
Przeglad Gastroenterologiczny |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Alimentary Pharmacology and Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
|
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Geburtshilfe und Frauenheilkunde |
Commentary/Editorial| Commentaire/Éditorial |
|
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Care of pregnant patients with COVID-19 and protection of newborns |
|
Geburtshilfe und Frauenheilkunde |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Commentary/Editorial| Commentaire/Éditorial |
|
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Covid-19: Mass shift to disinfectant
production across the world |
|
INFORM |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
|
Commentary/Editorial| Commentaire/Éditorial |
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Commentary/Editorial| Commentaire/Éditorial |
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Anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
|
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The Lancet Diabetes and Endocrinology |
Commentary/Editorial| Commentaire/Éditorial |
|
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The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
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The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
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IEEE Spectrum |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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Annals of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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ACEP Guideline on COVID-19: Ultrasound Machine and Transducer Cleaning |
|
Annals of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19: Use of Donated or Self-purchased Personal Protective Equipment |
|
Annals of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Care of Patients With Behavioral Health Emergencies and Suspected or Confirmed
COVID-19 |
|
Annals of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Medical Journal of Australia |
Commentary/Editorial| Commentaire/Éditorial |
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New England Journal of Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Empfehlungen zur Thromboseprophylaxe bei SARS-CoV-2 (COVID-19) |
|
Phlebologie |
Commentary/Editorial| Commentaire/Éditorial |
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Corrigendum to: Integrated Hospital Quarantine System against COVID-19 |
|
The Kaohsiung journal of medical sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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Journal of the Textile Institute |
Commentary/Editorial| Commentaire/Éditorial |
|
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The Lancet Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Informatics in Medicine Unlocked |
Commentary/Editorial| Commentaire/Éditorial |
|
Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives