Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-10-19
Good afternoon,
There are 356 citations in today’s scan. 194 were considered primary research or review literature.
Highlights today include:
CANADA
·
Arntfield et al. This study was conducted at two tertiary Canadian hospitals where a convolutional neural network (CNN) was trained on lung ultrasound
(LUS) images with B lines of different etiologies. CNN diagnostic performance, as validated using a 10% data holdback set was compared to surveyed LUS-competent physicians. The trained CNN performance on the independent dataset showed an ability to discriminate
between COVID (AUC 1.0), NCOVID (AUC 0.934) and HPE (AUC 1.0) pathologies. This was significantly better than physician ability (AUCs of 0.697, 0.704, 0.967 for the COVID, NCOVID and HPE classes, respectively).
·
Chen et al. conducted a systematic review, meta-analysis and modelling of respiratory viral loads (rVL) in COVID-19 cases compared to SARS and influenza
A (H1N1)pdm09. There was overdispersion in the rVL and heterogeneity in results. Overall rVL tended to peak at 1 day post symptom onset and be elevated for 1-5 days. Their kinetics of SARS-CoV-2 model shows that viral shedding spans >11 orders of magnitude
during the infectious period, thus most cases may present minimal risk of transmission by talking, singing or breathing. However, highly infectious cases can spread SARS-CoV-2 shedding SARS-Cov-2 up to tens to hundreds of virions/min. Symptomatic cases are
considered to be significantly more contagious than asymptomatic ones due to the increased virions shed during coughing.
PUBLIC HEALTH INTERVENTION
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Epperly, Rinehart, and Caney
estimates the relationships between aerosolized viral load concentrations present in a given environment containing infected persons, the exposure time duration, ventilation, mask usage, exercise /
activity level, and likelihood of infection, severity level, and immune response. This estimated total viral load accumulated within specific exposure time durations in the various environmental scenarios is then interpreted using human challenge viral load
escalation data into severity categories including Not Ill, Minor Illness, Clinical Mild Illness, and Possible Severe Illness. Immune response data related to these categories is also provided.
TRANSMISSION
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Ying et al formulate an agent-based model of customer movement in a supermarket with a simple virus transmission model based on the amount
of time a customer spends in close proximity to infectious customers. They apply the model to a synthetic store and shopping data to show how one can use it to estimate the number of infections due to human-to-human contact in stores and how to model different
store interventions.
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Vyas Dake
studies the relationship between environmental factors like UV radiation, air temperature, heat index and the incidence and transmission of COVID-19. Using an epidemiological observational study design with data from 3053 counties across the United States,
scatter plots with fit lines and the Spearman rank correlation, his model shows that high levels of UV irradiance, air temperature and heat indices were not associated with decreased incidence or transmission of COVID-19 cases.
EPIDEMIOLOGY
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Gandolfi, A.,
model the diffusion of the epidemic within each single school by an SEAIR model with an external source of infection and a suitable loss function, and then evaluate sustainable opening plans. His model finds that blended models, with almost periodic
alternations of in-class and remote teaching days or weeks, are generally (close to) optimal.
·
Martinelli et al.
conducted a retrospective epidemiological study to characterize asymptomatic COVID-19 cases in the Apulia region, Italy, during the first epidemic wave of COVID-19. The asymptomatic proportion was 19.9%; this decreased with increasing age, in individuals
with underlying comorbidities, and males. The median asymptomatic infectious period was 19 days, and the cumulative proportion of persons with a resolution of infection 14-days after the first positive PCR test was 74%.
·
Zhong et al
noted screened for bacteria and fungi infection in COVID-19 patients.
The result revealed that 5 mortality in positive group were all related to aspergillus infection while candida infection rarely caused death. Aspergillus was most common in non-survivors while candida was most common
in survivors. In terms of interleukin-6 (IL6), viral loads, nucleic acid clearance time, etc, fungal serologically positive group had a higher level than negative group.
THERAPEUTICS
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Alsharidah et al. Authors investigated the effectiveness of convalescent plasma (CCP) therapy in patients with moderate and severe COVID-19 disease. The
data show that administration of CCP is a safe treatment option for patients with COVID-19 disease, with a favorable outcome in the rate and time to clinical improvement.
CORONAVIROLOGY
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Hayn et al
systematically analysed the impact of 29 SARS-CoV-2 encoded proteins on three major arms of our cell-intrinsic innate immune defences: interferon (IFN) induction,
cytokine signalling and autophagy. Most antagonistic activities are conserved between proteins encoded by SARS-CoV-2, the closely related bat RaTG13-CoV and the highly pathogenic SARS-CoV-1.
SARS-CoV-1 Nsp15 is strikingly more potent in suppressing IFN induction and signalling than its SARS-CoV-2 counterpart. This may help explain the lower pathogenicity of SARS-CoV-2,
which facilitated its rapid spread. The results allow an explanation for differences in susceptibility towards IFNs and provide evidence that rational immune activation may be an effective future therapeutic strategy against SARS-CoV-2.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura
Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Alex Gilbert, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Evaluation of the relationship between inpatient COVID-19 mortality and chest CT severity score |
Abbasi, B, Akhavan, et al |
American Journal of Emergency Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The main purpose of this study was to evaluate the performance of a semi-quantitative CT severity score in identifying
the risk of mortality in COVID-19 patients. This retrospective cohort study was performed on 262 hospitalized COVID-19 patients. Our results show that mortality was significantly higher in patients with higher CT severity score even after adjustment for clinical,
demographics and laboratory parameters. |
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Response capacity to the COVID-19 pandemic in Latin America and the Caribbean |
Acosta, LD |
Revista Panamericana de Salud Publica/Pan American Journal of Public Health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Analyzed the evolution of the COVID-19 pandemic in Latin American and Caribbean countries in its first 90 days and its association with variables related
to public health measures, and demographic, health and social characteristics. Joinpoint regression analysis showed that the highest increase in the number of cases was observed in Brazil (11.3%) and the highest increase in crude mortality rate (CMR) in Mexico
(16.2%). The multiple correspondence analysis showed that CMR was associated with the total population, the stringency index, the level of urbanization, the proportion of the population living on less than one dollar a day, the prevalence of diabetes and the
number of hospital beds. |
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Descriptive
model of temporal features of multivariate time series based on granulation |
Afanasieva, T, Moshkina, et al |
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Epidemiology| Épidémiologie Surveillance |
Modern systems are characterized by high rates and volumes of receipt of numerical data. The number of indicators of economical, biological, and technical
systems, including Autonomous ones, is increasing, generating large amounts of numerical data of observation in real time. These data have a multidimensional structure and binding to time points, which allows us to consider them in the form of numerical multivariate
time series. As part of the descriptive analysis of these data, the article presents new model of representation of local features, considered at different levels of granulation, in respect to temporal features of a multivariate time series in terms of general
tendencies. For this purpose, the provisions of the theory of fuzzy sets and fuzzy time series were applied in descriptive model, which provided a linguistic description of tendencies, understandable to the expert. Carried out results in modelling of local
feature in terms of tendency in descriptive analysis of COVID-19 spread showed effectiveness and operability of proposed approach. Copyright © 2020 for this paper by its authors. |
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Uptake of telepractice among speech-language therapists following COVID-19 pandemic
in India |
Aggarwal, K, Patel, et al |
Speech, Language and Hearing |
Healthcare Response | Réponse des soins de santé |
This study aimed to explore the sudden uptake of telepractice in India among speech language therapists (SLTs). An online survey consisting of 20 questions
was carried out between 4 and 17 May 2020 using Google form. The participants comprised of SLTs who indicated that they had shifted their services to telepractice during the COVID-19 pandemic. Eighty-four SLTs participated in the study, working across different
work settings and from 21 to 53 years of age. Forty-nine percent of SLTs had conducted more than 11 telepractice sessions, 89% conducted only individual sessions. Further, 85% had a mostly paediatric caseload with 75% working with child language disorders.
They learnt about telepractice in a range of ways including from colleagues (19%), social media and the internet (18%), formal education (24%), reading (8%) and experience (8%). Overall, SLTs exhibited a positive attitude towards the use of telepractice. The
most common platform used was WhatsApp video calling feature (82%), although more than one platform was being used. The greatest challenges faced were dealing with network issues (38%) and lack of cooperation from the child during sessions (27%). The findings
highlight an acceptance and uptake towards telepractice. |
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Agüero, JM |
World Development |
Public Health response| Interventions de santé publique |
Stay-at-home policies have been implemented worldwide to reduce the spread of the SARS-CoV-2 virus. However, there is a growing concern that such policies
could increase violence against women. We find evidence in support of this critical concern. We focus on Peru, a country that imposed a strict nationwide lockdown starting in mid-March and where nearly 60% of women already experienced violence before COVID-19.
Using administrative data on phone calls to the helpline for domestic violence (Línea 100), we find that the incidence rate of the calls increased by 48 percent between April and July 2020, with effects increasing over time. The rise in calls is found across
all states and it is not driven by baseline characteristics, including previous prevalence of violence against women. These findings create the need to identify policies to mitigate the negative impact of stay-at-home orders on women's safety. © 2020 Elsevier
Ltd |
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Aguiar, M, Stollenwerk, et al |
Public health |
Epidemiology| Épidémiologie |
The objective of this study is to estimate the condition-specific case fatality ratio (CFR) for different subpopulations
in Italy. Condition-specific mortality risks are important to be evaluated during the COVID-19 pandemic, with potential elements to explain the CFR variability around the globe. |
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Akbariqomi, M, Hosseini, et al |
Diabetes research and clinical practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Aim: To describe the epidemiological and clinical characteristics along with outcomes of hospitalized Coronavirus Disease
2019 (COVID-19) patients with and without diabetes. Methods: This retrospective, single-center study included 595 consecutive hospitalized patients with confirmed COVID-19 at Baqiyatallah Hospital in Tehran, Iran, from February 26, 2020 to March 26, 2020.
Demographic data, clinical, laboratory, and radiological findings were collected and compared between patients based on diabetes status. Complications and clinical outcomes were followed up until April 4, 2020. Results: The most common symptoms included fever,
dry cough and dyspnea. A total of 148 patients (24.9%) had diabetes, and compared with patients without diabetes, these patients had more comorbidities; had higher levels of white blood cell count, neutrophil count, C-reactive protein, erythrocyte sedimentation
rate and blood urea nitrogen, and had a higher proportion of patchy ground-glass opacity in chest computed tomography findings. Significantly, patients with diabetes had more complications and needed more respiratory support than those without diabetes |
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Akhlaghi, Hamed, Vogrin, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Validated clinical rules are urgently needed to assist clinicians in their decision-making process in identifying admitted
COVID-19 patients at risk of in-hospital mortality and mechanical ventilation and appropriately allocating limited health care resources. Methods: A multi-centre observational study was performed on admitted COVID-19 patients between 1 March and 31 May 2020
in Iran. Patient characteristics, clinical manifestations and association with in-hospital mortality and orotracheal intubation were reported. Findings: The most common presentations were dyspnoea (53%), cough (53%), and fever (52%). 64% of patients had O2
saturation below 93% at the time of presentation. Orotracheal intubation was required in 298 of patients (7%) and 628 of patients (14%) died during admission. The features associated with in-hospital mortality were: age more than 65 years, arrival by ambulance,
dyspnoea, orotracheal intubation, O2 saturation below 93%, and a history of malignancy. The features associated with orotracheal intubation were: age more than 65 years, arrival by ambulance, dyspnoea, loss of consciousness, prior contact with a confirmed
COVID case, and O2 saturation below 93%. |
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Akimkin, VG, Kuzin, et al |
Voprosy virusologii |
Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions
de santé publique |
The aim of the study was to study the patterns inherent in the epidemic process of COVID-19 in a metropolis, in the
phases of rise, stabilization and decrease in the incidence, as well as to assess the effectiveness of anti-epidemic measures. A comprehensive study of the distribution of SARS-CoV-2 in Moscow was carried out using epidemiological, molecular genetic and statistical
research methods during the COVID-19 pandemic. It is shown that the use of the most stringent organizational and restrictive measures on a Moscow scale, ensuring the rupture of the transmission mechanism of SARS-CoV-2, and the high discipline of the population
in implementing the self-isolation regime made it possible to prevent an exponential increase in the incidence of COVID-19. An analysis of the dynamics of detecting new cases of COVID-19 showed that the effect of the application of measures for isolation and
the self-isolation regime in a metropolis occurs after a time interval equal to 3.5 incubation periods, with a maximum duration of 14 days. As a result of an epidemiological analysis of the situation with COVID-19 in Moscow, some patterns of the spread of
SARS-CoV-2 were identified and the effectiveness of anti-epidemic measures aimed at breaking the transmission mechanism of the pathogen was evaluated. |
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Social isolation and psychological wellbeing:
lessons from Covid-19 |
Al Issa, HE, Jaleel, et al |
Management Science Letters |
Public Health response| Interventions de santé publique |
This study explores the effect of social isolation (SI) on the psychological wellbeing (PWB) of employees due to the
imposed distance education during the Covid-19 pandemic lockdown. In this quantitative study, questionnaires were administered to measure SI, emotional intelligence (EI), and PWB among academic and non-academic staff in Iraqi public universities during the
height of the Covid-19 outbreak. The results suggest that EI and SI were strong predictors of PWB. While SI was negatively and significantly related to EI, the presence of emotional intelligence as a mediator reduced the negative effect of isolation on wellbeing.
Gender was not found to moderate the mediating effect of EI on the SI-PWB association. These findings support the validity of incorporating EI interventions during pandemic outbreaks that produce distinct effects on the isolation and thus potentially result
in improving the wellbeing of employees. |
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Alarcón Meza, EI, Hall-López, et al |
Retos |
Public Health response| Interventions de santé publique |
This study aims to compare the levels of physical activity in university athletes before and during the confinement
due to pandemic associated with COVID-19. 32 university student athletes enrolled in the Sports Faculty of the Autonomous University of Baja California. The average age of the participating subjects was 21.4 ± 3.6 years (17 men and 15 women). To assess the
physical activity level, the international physical activity questionnaire (IPAQ) was used; measurements were carried out before and during confinement by COVID-19. To determine equality of variance, the Student’s t-test for independent samples was applied,
with less physical activity (-33.6 Ä%), MET-minutes/week during confinement by COVID-19 (p=.005). Despite decreasing physical activity, the university athlete performed physical activity at home during confinement by COVID-19, harmonizing the time in the
learning processes in their future profession. |
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Optimal control on COVID-19 eradication program in Indonesia under the effect of community
awareness |
Aldila, D, Ndii, et al |
Mathematical Biosciences and Engineering |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
In this study, mathematical models with nonpharmaceutical and pharmaceutical interventions were formulated and analyzed.
The first model was formulated without the inclusion of community awareness. The analysis focused on investigating the mathematical behavior of the model, which can explain how medical masks, medical treatment, and rapid testing can be used to suppress the
spread of COVID-19. In the second model, community awareness was taken into account, and all the interventions considered were represented as time-dependent parameters. Using the center-manifold theorem, we showed that both models exhibit forward bifurcation.
The infection parameters were obtained by fitting the model to COVID-19 incidence data from three provinces in Indonesia, namely, Jakarta, West Java, and East Java. Furthermore, a global sensitivity analysis was performed to identify the most influential parameters
on the number of new infections and the basic reproduction number. We found that the use of medical masks has the greatest effect in determining the number of new infections. The optimal control problem from the second model was characterized using the well-known
Pontryagin’s maximum principle and solved numerically. The results of a cost-effectiveness analysis showed that community awareness plays a crucial role in determining the success of COVID-19 eradication programs. |
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Alenazi, TH, BinDhim, et al |
Journal of Infection and Public Health |
Healthcare Response | Réponse des soins de santé |
This study aimed to explore the anxiety levels among HCWs in Saudi Arabia during the COVID-19 pandemic and the predictors
of increased anxiety levels. HCW participants in this cross-section study were solicited by email from the database of registered practitioners of the Saudi Commission for Health Specialties between 15 May and 18 May 2020. Four thousand nine hundred and twenty
HCWs (3.4%) responded. Reported levels of anxiety were low anxiety (31.5%; n = 1552), medium (36.1%; n = 1778), and high (32.3%; n = 1590). Participants reporting high anxiety levels were more likely to be unmarried (OR = 1.32, 95% CI: 1.14–1.52); nurses (OR
= 1.54, 95% 1.24–1.91); workers in radiology (OR = 1.52, 95% CI: 1.01–2.28); or respiratory therapists (OR = 2.28, 95% CI: 1.14–4.54). Social factors associated with high anxiety levels were: living with a person who is elderly (p = 0.01), has a chronic disease
(p < 0.0001), has immune deficiency (p < 0.0001), or has a respiratory disease (p-value <0.0001). Organization-related factors associated with a high level of anxiety were: working in an organization that hosts COVID-19 patients and working with such patients
(p-value <0.0001). Self-reported medium and high levels of anxiety were present in 68.5% of HCWs in the COVID-19 pandemic. |
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Alhusseini, N, Alqahtani, et al |
Journal of Public Health Research |
Public Health response| Interventions de santé publique |
A cross-sectional study was conducted through an online survey to describe the impact of the COVID-19 pandemic on the
eating habits, quality and quantity of food intake among adults in Saudi Arabia. Dietary habits have changed significantly during the COVID-19 pandemic among Riyadh residents. |
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Association of Social Determinants of Health with COVID-19 Mortality
in the U.S |
Alishahi Tabriz, Amir, Turner, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie |
We used a two-part model at the county level in which the first model was a multivariable-adjusted regression for the
binary outcome (county with/without at least 1 reported COVID-19 death) and the second was a multivariable-adjusted model with log normal distribution for counties having non-zero deaths. The percentage of Blacks (average marginal effect (AME): 0·32, 95% CI=0·16
– 0·48), percentage of Hispanics (AME: 0·22, 95% CI=0·12 – 0·37), and log transformed population density (AME: 8·77, 95% CI=7·25 – 10·29), were positively, and percentage of Asian or Pacific Islander (AME: -0·63, 95% CI=-0·87 – -0·38), and being a complete
rural county ( |
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AlJishi, JM, Al-Tawfiq, et al |
Journal of Hospital Infection |
Clinical data| Données cliniques |
Here, we describe the occurrence of intermittent positive PCR and the duration of viral PCR positivity in patients
with SARS-CoV-2 infection in patients admitted to Qatif Central Hospital, Saudi Arabia. |
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Almalki, ZS, Khan, et al |
Journal of Multidisciplinary Healthcare |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The purpose of this research was to identify the clinical characteristics and outcomes of COVID-19 patients with chronic
conditions. Patients and Methods: A retrospective cross-sectional single-center study was conducted using electronic medical records of hospitalized COVID-19 patients between March 1, 2020, and May 20, 2020. Patients’ basic information, laboratory test, clinical
data, medications, and out-come data have been extracted and compared among three groups: patients without chronic conditions, patients with one chronic condition, and patients with two or more chronic conditions. Results: There were 14 (14.3%) smokers, and
the majority of them were among patients with two or more chronic conditions. Longer hospital stay and time in the intensive care unit (ICU), a higher probability of ICU admission, and the need for mechan-ical ventilation were identified among patients with
two or more chronic conditions. Dyspnea, an increased level of platelet counts, and a reduction in hemoglobin levels were discovered among patients with two or more chronic conditions. Conclusion: Patients with more chronic conditions were at higher risk of
yielding poor clinical outcomes. |
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Almazrou, SH, Almalki, et al |
Saudi Pharmaceutical Journal |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Authors assess possible treatments such as pharmacological treatments including antivirals (Lopinavir/Ritonavir), Immuno-modulatory
and anti-inflammatory drugs including, Tocilizumab and Hydroxychloroquine (HCQ) which have been been widely investigated as a treatment for COVID-19. HCQ had a modest effect on hospital length stay and days in ICU compared with standard care. |
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Alrabaiah, H, Arfan, et al |
Alexandria Engineering Journal |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this research work, a non-linear dynamical modified SEIR model of the recent pandemic, due to Coronavirus-19 disease
(COVID-19) for different countries like Malaysia and Pakistan, is considered under nonsingular fractional order derivative. For this model, some qualitative results, existence theory, and numerical solution are studied by using fixed point approach and fractional
Adams-Bashforth method. The results are simulated corresponding to some real data of various fractional order by using Matlab. Hence, the suitability of the considered COVID-19 model for the current outbreak in two different countries Malaysia and Pakistan
are shown by simulation. © 2020 Faculty of Engineering, Alexandria University |
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Alsalhe, TA, Aljaloud, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
This study aimed to investigate the effects of the fear of COVID-19, level of physical activity, and gender on negative
stress (distress) in an Arab population. Results confirmed the links between level of physical activity, fear of COVID-19, and gender, showing a significant mediating effect of the fear of COVID-19 on the relationship between gender and general distress. The
level of physical activity was also found to influence the fear of COVID-19, varying depending on gender. |
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Alsharidah, Sondas Ibrahim, Ayed, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Authors investigated the effectiveness of convalescent plasma (CCP) therapy in patients with moderate and severe COVID-19
disease. The data show that administration of CCP is a safe treatment option for patients with COVID-19 disease, with a favorable outcome in the rate and time to clinical improvement. |
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Areaux, RG, J, et al |
Journal of AAPOS |
Healthcare Response | Réponse des soins de santé |
Although few US ophthalmology practices incorporated telemedicine prior to COVID-19, its use has now become the norm.
Regarding the use of synchronous patient-to-provider virtual visits (SPPVV) in pediatric ophthalmology, we have pooled our collective experience at three academic practices across the country to describe initial workflows, technology solutions, use cases,
and barriers to care. |
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Arntfield, Robert, VanBerlo, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study was conducted at two tertiary Canadian hospitals where a convolutional neural network (CNN) was trained
on lung ultrasound (LUS) images with B lines of different etiologies. CNN diagnostic performance, as validated using a 10% data holdback set was compared to surveyed LUS-competent physicians. The trained CNN performance on the independent dataset showed an
ability to discriminate between COVID (AUC 1.0), NCOVID (AUC 0.934) and HPE (AUC 1.0) pathologies. This was significantly better than physician ability (AUCs of 0.697, 0.704, 0.967 for the COVID, NCOVID and HPE classes, respectively), p < 0.01. |
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Arumugam, A, Faron, et al |
Diagnostics |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Using COVID-19 clinical specimens, we have collected evidence that the RT-qPCR assay can feasibly be performed directly
on patient sample material in virus transport medium (VTM) without an RNA extraction step, while still producing sensitive test results. If RNA extraction steps can be omitted without significantly affecting clinical sensitivity, the turn-around time of COVID-19
tests, and the backlog we currently experience can be reduced drastically. Furthermore, our data suggest that rapid RT-PCR can be implemented for sensitive and specific molecular diagnosis of COVID-19 in locations where sophisticated laboratory instruments
are not available. Our USD 300 set up achieved rapid RT-PCR using thin-walled PCR tubes and a water bath setup using sous vide immersion heaters, a Raspberry Pi computer, and a single servo motor that can process up to 96 samples at a time. Using COVID-19
positive clinical specimens, we demonstrated that RT-PCR assays can be performed in as little as 12 min using untreated samples, heat-inactivated samples, or extracted RNA templates with our low-cost water bath setup. These findings can help rapid COVID-19
testing to become more accessible and attainable across the globe. |
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Teaching intervention in physical education during quarantine for COVID-19 |
Baena-Morales, S, López-Morales, et al |
Retos |
Public Health response| Interventions de santé publique |
The aim of this study was to describe the changes in teaching intervention in Physical Education because of the quarantine
caused by COVID-19. Data was collected from 191 active teachers by an online questionnaire, which consisted of 15 questions grouped into three main dimensions: contents reorganization, evaluation analysis and methodological changes. The main results of this
study indicated that most of the teachers did not continue with the teaching hours prior quarantine. Regarding the evaluation, a high percentage of teachers neither planned it nor found it feasible. Contents of Physical condition and health were the most commonly
used among teachers. Additionally, several difficulties were detected regarding the implementation of virtual teaching. Finally, the majority of teachers answered that quarantine could involve psychological and health problems for their students. These results
could be considered for future research focused on Virtual Physical Education. © Copyright: Federación Española de Asociaciones de Docentes de Educación Física (FEADEF). |
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Baggiani, A, Briani, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
In Italy, the coronavirus disease 2019 (COVID-19) emergency took hold in Lombardy and Veneto at the end of February
2020 and spread unevenly among the other regions in the following weeks. In Tuscany, the progressive increase of hospitalized COVID-19 patients required the set-up of a regional task force to prepare for and effectively respond to the emergency. In this case
report, we aim to describe the key elements that have been identified and implemented in our center, a 1082-bed hospital located in the Pisa district, to rapidly respond to the COVID-19 outbreak in order to guarantee safety of patients and healthcare workers.
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
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Druglords don't stay at home: COVID-19 pandemic and crime patterns in Mexico
City |
Balmori de la Miyar, JR, Hoehn-Velasco, et al |
Journal of Criminal Justice |
Public Health response| Interventions de santé publique |
This study aims to investigate the effect of the COVID-19 pandemic on conventional crime and organized crime in Mexico
City, Mexico. We find a sharp decrease on crimes related to domestic violence, burglary, and vehicle theft; a decrease during some weeks on crimes related to assault-battery and extortion, and no effects on crimes related to robbery, kidnapping, and homicides. |
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Asthma Disparities During the COVID-19 Pandemic: A Survey of Patients and Physicians |
Baptist, AP, Lowe, et al |
Journal of Allergy and Clinical Immunology: In Practice |
Public Health response| Interventions de santé publique |
This study aimed to determine factors contributing to health disparities in those with asthma during the COVID-19 pandemic.
A total of 1171 patients (10.1% minority individuals) and 225 physicians completed the survey. Minority patients were more likely to have been affected by COVID-19 (eg, became unemployed, lived in a community with high COVID-19 cases). They had worse asthma
control (increased emergency visits for asthma, lower Asthma Control Test score), were more likely to live in urban areas, and had a lower household income. Initial differences in attitudes and health behaviors disappeared after controlling for baseline demographic
features. Institutional racism was demonstrated by findings that minority individuals were less likely to have a primary care physician, had more trouble affording asthma medications due to COVID-19, and were more likely to have lost health insurance because
of COVID-19, and that 25% of physicians found it more challenging to care for black individuals with asthma during COVID-19. |
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Telemedicine in oral and maxillo-facial surgery: An effective alternative in post COVID-19
pandemic |
Barca, I, Novembre, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
The aim of this work was to demonstrate the advantages of using telemedicine (TM) in the management of the outpatients
with maxillofacial surgical pathologies during the COVID-19 pandemic. The study was conducted at the MaxilloFacial Surgery Unit of “Magna Graecia” University of Catanzaro, on two different groups of patients: a group of follow-up patients (A1: patients in
oncological follow-up after surgical treatment performed before the COVID-19 pandemic; A2: suffering from chronic lesions such as precancerous lesions), and a group B of patients with first urgent visits (B1: patients with suspected oncological pathology;
B2: patients with suspected urgent disease such as medication-related osteonecrosis of the jaws (MRONJ), odontogenic abscesses, temporomandibular joint (TMJ) dislocation, etc.). Participation in the study required possession of a smartphone with Internet access,
e-mail and the use of a messaging service (WhatsApp or Telegram) to send photos and messages; completion by the patient of a COVID-19 screening questionnaire; submission of a satisfaction questionnaire by the doctors and patients. A total of 90 patients were
included in this study. A high percentage of satisfaction emerged from the analysis of the satisfaction questionnaires of both patients and doctors.TM thus represents an excellent opportunity to improve accessibility to oncological and non-management activities,
reducing the risk of Covid-19 dissemination and should be promoted and implemented in the postpandemic era. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
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A case of Guillain-Barrè syndrome
associated with SARS-CoV-2 infection |
Busillo, V, Lerza, et al |
Pharmacologyonline |
Clinical data| Données cliniques |
We report a case of Guillain-Barrè syndrome in a 75-year-old female associated with SARS-CoV2 infection. |
|
The timing and intensity of social distancing to flatten the COVID-19 curve: The case
of Spain |
Casares, M, Khan, et al |
International Journal of Environmental Research and Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We present a dynamic model to quantify the impact of isolation for the contagion curves. The model is calibrated to
the COVID-19 outbreak in Spain to study the effects of the isolation enforcement following the declaration of the state of alarm (14 March 2020). The simulations indicate that both the timing and the intensity of the isolation enforcement are crucial for the
COVID-19 spread. For example, a 4-day earlier intervention for social distancing would have reduced the number of COVID-19 infected people by 67%. The model also informs us that the isolation enforcement does not delay the peak day of the epidemic but slows
down its end. When relaxing social distancing, a reduction of the contagion probability (with the generalization of preventive actions, such as face mask wearing and hands sanitizing) is needed to overcome the effect of a rise in the number of interpersonal
encounters. We report a threshold level for the contagion pace to avoid a second COVID-19 outbreak in Spain. |
|
Cavalera, S, Colitti, et al |
Talanta |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
A rapid test for detecting total immunoglobulins directed towards the nucleocapsid protein (N) of severe acute syndrome
coronavirus 2 (SARS CoV-2) was developed, based on a multi-target lateral flow immunoassay comprising two test lines. Both test lines bound to several classes of immunoglobulins (G, M, and A). Specific anti-SARS immunoglobulins were revealed by a colorimetric
probe formed by N and gold nanoparticles. Targeting the total antibodies response to infection enabled achieving 100% diagnostic specificity (95.75–100, C.I. 95%, n = 85 healthy and with other infections individuals) and 94.6% sensitivity (84.9–98.9, C.I.
95%, n = 62 SARS CoV-2 infected subjects) as early as 7 days post confirmation of positivity. Agreeing results with a reference serological ELISA were achieved, except for the earlier detection capability of the rapid test. Follow up of the three seroconverting
patients endorsed the hypothesis of the random rise of the different immunoglobulins and strengthened the ‘total antibodies’ approach for the trustworthy detection of serological response to SARS CoV-2 infection. © 2020 Elsevier B.V. |
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Heterogeneity in transmissibility and shedding SARS-CoV-2
via droplets and aerosols |
Chen, PaulZ, Bobrovitz, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission |
Here, we developed a comprehensive dataset of respiratory viral loads (rVLs) via systematic review and investigated
these factors using meta-analyses and modeling. Asymptomatic and symptomatic infections showed similar likelihoods of expelling aerosols with 37 SARS-CoV-2, as did adult and pediatric cases. |
|
Chhikara, K, Kanta, et al |
Diagnostic microbiology and infectious disease |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In this study, the authors have optimized and compared the effect of pooling (5 and 10 samples) before and after nucleic
acid extraction to test for SARS-CoV-2. It was concluded that there was no significant difference in the SARS CoV-2 RNA detection in the pools prepared at sample or RNA level. Even after pooling, 10-fold dilution was detectable with 3–cycle threshold value
change in both type of pools when compared with individual samples. Hence, sample pool size of 10 can be used in low-prevalent areas, and testing capacity can be substantially increased. |
|
|
Choi, WS, Jeong, et al |
Diagnostics |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In this study, we developed a peptide nucleic acid (PNA)-based real-time quantitative polymerase chain reaction (RT-qPCR)
assay targeting the N gene to efficiently discriminate SARS-CoV-2 from other SARSr-CoVs in human clinical samples. Without compromising the sensitivity, this method significantly enhanced the specificity of SARS-CoV-2 detection by 100-fold as compared to conventional
RT-qPCR. In addition, we designed an RT-qPCR method for the sensitive and universal detection of ORF3ab-E genes of SARSr-CoV with a limit of detection (LOD) of 3.3 RNA copies per microliter. Thus, the developed assay serves as a confirmative dual-target detection
method. Our PNA-mediated dual-target RT-qPCR assay can detect clinical SARS-CoV-2 samples in the range of 18.10–35.19 Ct values with an 82.6–100% detection rate. Furthermore, our assay showed no cross-reactions with other coronaviruses such as human coronaviruses
(229E, NL63, and OC43) and Middle East respiratory syndrome coronavirus, influenza viruses (Type B, H1N1, H3N2, HPAI H5Nx, and H7N9), and other respiratory disease-causing viruses (MPV, RSV A, RSV B, PIV, AdV, and HRV). We, thus, developed a PNA-based RT-qPCR
assay that differentiates emerging pathogens such as SARS-CoV-2 from closely related viruses such as SARSr-CoV and allows diagnosis of infections related to already identified or new coronavirus strains. |
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|
Chua, KYL, Vogrin, et al |
Pathology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Patient sera were collected at least 6 weeks following onset of COVID-19 infection symptoms. Negative control specimens
were stored specimens from those without COVID-19, collected in April–May 2019. Sensitivity and specificity with 95% confidence intervals (CI) were calculated. The clinical sensitivity of the Elecsys assay was 98.84%, specificity was 100%; the Liaison assay
clinical sensitivity was 96.51%, specificity was 97.89%; the Access assay clinical sensitivity was 84.88%, specificity was 98.95%; and the Vitros assay clinical sensitivity was 97.67%, specificity was 100%. |
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The Impact of the COVID-19 Quarantine on Sexual Life in Italy |
Cito, G, Micelli, et al |
Urology |
Public Health response| Interventions de santé publique |
The aim of the study is to evaluate how individual and couple's sexuality had changed during the COVID-19 pandemic-related
quarantine. The majority of quarantined participants experienced reduced number of SI per week, with poor household privacy and lack of psychological stimuli as cited causes, even as a majority did not report reduced autoeroticism. |
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Subtle Olfactory Dysfunction after SARS-CoV-2 Virus Infection
in Children |
Conchiero-Guisan, Ana |
SSRN- Lancet prepublication |
Clinical data| Données cliniques |
This study is aimed to determine the presence of olfactory dysfunction in children with COVID-19 infection through
the use of a self-reported questionnaire and a new olfactory screening tool. All paediatric patients screened by reverse transcription polymerase chain reaction (RT-PCR) and Anti-SARS-CoV-2 antibodies for COVID-19 infection, during the study period (March-May
2020), were asked to respond to a questionnaire about olfactory disfunction symptoms. Patients above six years of age also performed an odor identification test based on seven odorants (Kradeo®). This test was designed based on our cultural context and eating
habits. 126 patients were recruited, including 33 with COVID-19 infection. 15% of the infected children referred anosmia and/or dysgeusia on the questionnaire, all of them were older than eleven years. The results of the odor test (69 patients) revealed subtle
disturbances in the infected group (mostly misrecognition of odorants). Median odorant recognition was 3 odors Interquartile range (ICR) 2-4] in case group and 4 ICR 3-5] in controls. Male patients showed significantly bigger disturbances than girls in both
groups (p=0·03). Self-referred prevalence of olfactory disfunction in our sample of infected children is lower than that described in adults, especially among the youngest ones, maybe due to immature development of angiotensin-converting enzyme 2 (ACE2) receptors
expressed in nasal mucosa. |
|
Conway, J, Gould, et al |
Diabetes research and clinical practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aim to present the characteristics of patients with diabetes admitted to hospital with COVID-19. Design: A retrospective
case series. Setting: A single clinical centre in the UK. Methods: We have retrospectively collected the demographics, medical characteristics and outcome of all patients with diabetes admitted to hospital over two-week period with COVID-19 infection. All
cases were diagnosed by a reverse transcription polymerase chain reaction (RT-PCR) of pharyngeal and nasal swabs. Results: There was no significant difference between patients with compared to those without diabetes regarding age, gender or clinical presentation.
However, comorbidities were more common in patients with diabetes specially hypertension and chronic kidney disease. Patients with diabetes were significantly more obese than those without diabetes. Patients with diabetes hospitalised for COVID-19 were significantly
more obese and had high prevalence of comorbidities than those without diabetes. |
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Dai, ChengzhenL, Kornilov, et al |
medRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We evaluated the sociodemographic and clinical characteristics of patients across the major racial/ethnic groups and
assessed their associations with COVID-19 outcomes. Methods This retrospective cohort study analyzed patients who were tested for SARS-CoV-2 in a large, integrated health system spanning California, Oregon, and Washington between March 1 and August 30, 2020.
Sociodemographic and clinical characteristics were obtained from electronic health records. Odds of SARS-CoV-2 infection, COVID-19 hospitalization, and in-hospital death were assessed with multivariate logistic regression. Findings 15,605 persons tested positive,
with minorities representing 58.0%. Disparities were widest among Hispanics, who represented 40.5% of infections but 12.8% of those tested. Hispanics were generally younger and had fewer comorbidities except diabetes than White patients. Of the 3,197 patients
hospitalized, 58.9% were non-White. 459 patients died, of whom 49.8% were minorities. Racial/ethnic distributions of outcomes across the health system tracked with state-level statistics. Increase odds of testing positive and hospitalization were associated
with all minority races/ethnicities except American Indian/Alaska Native. |
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|
Dake, Vya |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Transmission |
Understanding the relationship between environmental factors like UV radiation, air temperature, heat index and the
incidence and transmission of COVID-19 will help us predict geographic and seasonal variation in transmission. An epidemiological observational study design was utilized with data from 3053 counties across the United States. The data on average daily maximum
air temperature and average daily maximum heat index were obtained from Centers for Disease Control (CDC) under the environment dataset. The data for Population weighted UV irradiance and COVID-19 case count by county were obtained from environmental health
and toxicology dataset and case surveillance dataset respectively. The scatter plots with fit lines showed no correlation between UV Irradiance and COVID-19 case counts but showed a weak positive correlation between Air Temperature and Heat index and COVID-19
case counts. Based on the county wise data across the United States, high levels of UV irradiance, air temperature and heat indices were not associated with decreased incidence or transmission of COVID-19 cases. |
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Blood Component Therapy in COVID-19 Patients Hospitalized in a
Tertiary Care Centre in Eastern India |
Das, Sudipta Sekhar, Biswas, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Here we described the pattern of blood usage in COVID-19 patients in our hospital with regards to indications, clinical
and laboratory evaluations and blood and blood component transfusions. This is a retrospective study that included 34 hospitalized transfused patients admitted with clinical features and diagnosis of COVID-19. Among the 419 hospitalized COVID-19 patients 34
(8.1%) received blood transfusion. Levels of D-dimer, serum ferritin and IL-6 as high as 8545 ng/mL, 8486 ng/mL and 256 pg/mL respectively were observed in few patients. Co-morbidity was demonstrated in 91.2% transfused patients. A total of 6 (17.6%) patients
succumbed to the disease. Packed red blood cell was the main blood component transfused to COVID-19 patients followed by platelet and plasma products. A rise in trend in blood utilization was demonstrated from March to June 2020 with a dip in July 2020. Compared
to other months more patients required platelet concentrates in June 2020. |
|
De la Torre, David, Pibaque, et al |
Research Square prepub |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We develop, standardize and validate an in-house protocol that cannot only reduces testing costs, but also increase
the ability to screen widely the population. The primer efficiency was set at 94.9% and R2 value at 0.99, which was comparable to commercial kits. The lower detection limit was found at 15 copies/ μL (50 copies/rx). In comparison to a Loop-mediated Isothermal
Amplification (LAMP) commercial kit, there was a higher detection rate (30%) and results were highly reproducible (95%). |
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Guillain-Barré syndrome in a patient previously diagnosed with COVID-19 |
Defabio, AC, Scott, et al |
American Journal of Emergency Medicine |
Clinical data| Données cliniques |
We present a case of Guillain-Barre Syndrome (GBS) secondary to a COVID-19 infection and believe this to be the first
documented female case in the US and the second documented case in the US overall. |
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High-flow nasal cannula in critically Ill patients with severe COVID-19 |
Demoule, A, Baron, et al |
American Journal of Respiratory and Critical Care Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To test the hypothesis that high-flow nasal cannula (HFNC) oxygen reduces intubation rate and mortality in patients
with COVID-19 admitted to the ICU for acute respiratory failure, we designed this retrospective study that compares patients who received HFNC to those who did not in a cohort of 379 critically ill patients. |
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Analysis and Prediction of COVID-19 Outbreak by the Numerical Modelling |
Dilshad, Azad Mohammed, Hassan, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study estimated the basic reproductive number (R0) for COVID-19 in Kurdistan Region of Iraq (KRI), using the standard
SIR (Susceptible-Infected-Removed) epidemic model. Reproductive numbers R0 have been estimated by by the 4th order Runge-Kutta method of fitting the curves between the actual daily data and numerical solution by applying the least square method. For the analysis,
data were taken for the duration of 165 days from 1st of March to 12th August in a population of 5.2 million. It has been concluded that R0 is fluctuating during the outbreak with an average of 1.33, predicting that infected cases will reach their maximum
value of around 540,000 on 5th of November 2020. Then the spread of the disease will die out since the number of susceptible will decrease to about 3.2 million. While the number of removed individuals will reach approximately to 1.5 million. |
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Design of SARS-CoV-2 RBD mRNA Vaccine Using Novel Ionizable
Lipids |
Elia, Uri, Srinivas, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins Animal model | Modèle animal |
In this study, we present the design of a lipid nanoparticles (LNP)-encapsulated receptor binding domain (RBD) mRNA
vaccine. Several ionizable lipids have been evaluated in vivo in a luciferase mRNA reporter assay, and two leading LNPs formulation have been chosen for the subsequent RBD mRNA vaccine experiment. Intramuscular administration of LNP RBD mRNA elicited robust
humoral response, high level of neutralizing antibodies and a Th1-biased cellular response in BALB/c mice. These novel lipids open new avenues for mRNA vaccines in general and for a COVID19 vaccine in particular. |
|
Epperly, DavidE, Rinehart, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
This study helps answer the question "How long may a person safely remain within a given environment and what is the
associated risk relative to other environments". The estimates herein may help efforts to strike a balance in developing holistic epidemiologic interventions that consider the effects of these interventions on economic, civic, social, and mental health, which
have pathologies within their own realms. |
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Eslami, V, Abrishami, et al |
Academic Radiology |
Clinical data| Données cliniques |
We hypothesized that CT-measured cardiac indices are correlated with severity of lung involvement and can predict survival
in patients with COVID-19. Eighty-seven patients with confirmed COVID-19 who underwent chest CT were enrolled. Mean (±SD) age of patients was 54.55 (±15.3) years old; 65.5% were male. Increased CTR (>0.49) was seen in 52.9% of patients and was significantly
associated with increased odds and hazard of death (odds ratio OR] = 12.5, p = 0.005; hazard ratio = 11.4, p = 0.006). PA/A >1 was present in 20.7% of patients and displayed a nonsignificant increase in odds of death (OR = 1.9, p = 0.36). Furthermore, extensive
lung involvement was positively associated with elevated CTR and increased PA/A (p = 0.001). |
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Life conditions during COVID-19 lockdown and mental health in Spanish adolescents |
Ezpeleta, L, Navarro, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
Spanish children were locked down for 72 days due to COVID-19, causing severe disruption to their normal life. The
goal was to study the life conditions of adolescents during lockdown and their association with psychological problems. Conduct, peer, prosocial, and total problems scores increased after lockdown. After adjusting for previous measures of psychopathology,
worse adolescents’ mental health during COVID-19 lockdown was associated with unhealthy activities, worsening of the relationships with others, and dysfunctional parenting style. |
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Shift Work Is Associated with Increased Risk of COVID-19: Findings
from the UK Biobank Cohort |
Fatima, Yaqoot, Bucks, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie |
Assessed whether shift work, particularly night shift, increases the odds of COVID-19 infection. Among the 12,428 participants
(13.2% positive cases) around 1 in 6 were frontline health workers (16.2%) with 1 in 5 involved in a shift work-based job (21.2%). Within the shift work-based jobs, people who worked mostly night shift were at the highest risk of COVID-19 infection (23.6%).
Adjusted logistics regression model suggest that compared with their counterparts, people employed in a night-shift based job were 1.82 times more likely to have COVID-19 infection Although health workers were found to have a significantly higher risk of COVID-19
infection than other occupational groups (14.6 vs 8.8%), and a significant proportion of the healthcare workforce was comprised of shift workers (37.1 % vs 17.2), this did not confound the association between shift work and COVID-19 infection. Sensitivity
analysis, focusing on people working in a non-healthcare setting, suggests that people in shift work based jobs were 1.79 times more likely to have COVID-19 infection than their counterparts. |
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A simple tool for comparing benefits and ‘costs’ of COVID-19 exit strategies |
Frank, J, Williams, et al |
Public health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Propose the population attributable risk (PAR) as an established epidemiological tool that could support decision-making
through quickly estimating the main benefits and costs of various exit strategies. demonstrate the feasibility of use of PAR using pandemic data, that were publicly available in mid-May 2020 from Scotland and the US, to estimate the proportion of COVID-19
hospital admissions which might be avoided, and the proportion of adverse labour market effects – for various scenarios – based on maintaining the lockdown for those of certain ages with and without comorbidities. These calculations could be refined and applied
in different countries to inform important COVID-19 policy decisions, using routinely collected data. |
|
Fu, XY, Shen, et al |
American Journal of Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
This study explores the effect of COVID-19 outbreak on the treatment time of patients with ST-segment elevation myocardial
infarction (STEMI) in Hangzhou, China. The times of symptom onset to the first medical contact (SO-to-FMC), time from hospital door entry to first balloon expansion (D-to-B), and catheter room activation time in the 2020 group were significantly longer than
those in the 2019 group (P < 0.05). The cumulative mortality after the surgery in the 2020 group was significantly higher than the 2019 group (P < 0.05). |
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Gandolfi, A |
Physica D |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In order to support the possibility of some in-person learning, we model the diffusion of the epidemic within each
single school by an SEAIR model with an external source of infection and a suitable loss function, and then evaluate sustainable opening plans. It turns out that blended models, with almost periodic alternations of in-class and remote teaching days or weeks,
are generally (close to) optimal. In a prototypical example, the optimal strategy prescribes a school opening of 90 days out of 200 with the number of Covid-19 cases among the individuals related to the school increasing by about 67% with respect to no opening,
instead of the about 200% increase that would have been a consequence of full opening. As clinical fraction is low in children, these solutions could lead to very few or no symptomatic cases within the school during the whole school year. Using the prevalence
of active cases as a proxy for the number of pre- and asymptomatic, we get a preliminary indication for each country of whether either full opening, or blended opening with frequent testing, or no school opening at all, is advisable. |
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The status
of grief counseling among front-line nurses during the coronavirus disease 2019 epidemic |
Gao, XD, Kong, et al |
Academic Journal of Second Military Medical University |
Healthcare Response | Réponse des soins de santé |
To investigate the status of grief counseling among front-line nurses in Wuhan during the COVID-19 epidemic, so as
to provide reference for formulating reasonable nursing management strategies. A total of 214 valid questionnaires were collected, with an effective rate of 95.1%. The score of grief counseling attitudes of nurses was 32.80±9.41, which was in the middle level.
Other grief counseling skills, communication ability, whether they had received relevant training, and frequency of contacting bereaved family members had significant impacts on nurses' grief counseling attitudes (P＜0.05).
The score of grief counseling skills was 19.24±4.10, which was in the lower middle level. Grief counseling, frequency of contacting bereaved family members, grief counseling training, and education background had significant impacts on nurses' grief counseling
skills (P＜0.05). |
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A survey of grief counseling of clinicians from coronavirus disease 2019
designated hospitals |
Gao, XD, Kong, et al |
Academic Journal of Second Military Medical University |
Healthcare Response | Réponse des soins de santé |
To investigate the current status of grief counseling of clinicians from five coronavirus disease 2019 (COVID-19) designated
hospitals in Wuhan and to provide reference for hospital management. A total of 208 valid questionnaires were collected, with an effective rate of 93.3%. The score of grief counseling skills of clinicians from COVID-19 designated hospitals was 19.35±4.75,
which was in the middle and lower level. Responsibilities and roles, and frequency of contacting bereaved family members had significant effects on the grief counseling skills (P＜0.01).
While the score of grief counseling attitudes of clinicians was 33.21±9.23, which was in the middle level. Whether they had received relevant training, the communication ability, and other grief counseling skills had significant impacts on their grief counseling
attitudes (P＜0.01). The skills and attitudes of grief counseling
of clinicians from COVID-19 designated hospitals in Wuhan still need to be improved. |
|
Garg, Surbhi, Alvi, et al |
medRxiv |
Public Health response| Interventions de santé publique |
This paper investigates the prevalence of socio-demographic correlations of access to sanitary napkins among college
students in Lucknow during the COVID19 lockdown. An online retrospective cross-sectional survey was conducted in September 2020, including 1371 participants. Nearly 12.5 percent of students reported about difficulty encountered during the lockdown. Muslims,
Father education illiterate or upto 12th, father occupation as farmer, monthly salary less than 25 thousand, residence as rural, and history of reusable clothes were more likely to face problems to access sanitary pads during the lockdown (P < .05). Because
of the lockdown, many people have lost their livelihood. More than ever, economically low-income families are reluctant to spend on sanitary pads, which is why few college girls were going back to their previous handling periods by using rags. |
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|
Gasimov, Zaur, Dadashova, et al |
SSRN- Lancet prepublication |
Healthcare Response | Réponse des soins de santé |
The objective was to study the impact of quarantine during COVID-19 pandemic on admission of patients with myocardial
infarction to the intensive cardiac care unit (ICCU) of Research Institute of Cardiology (RIC). We conducted a single-centre,observational survey to collect data on admissions for acute myocardial infarction(AMI) at ICCU RIC during strict quarantine in April-May
2020,in Baku,Azerbaijan,compared with April-May 2019. We observe 10% reduction in admission rate for AMI’s patients admitted at ICCU RIC in April-May 2020 in comparison to April-May 2019.We observed significant 40% reduction in admissions for AMI in April
2020 compared with April 2019, it also turned out to be the lowest number of ICCU admissions for AMI among all months of the last 5 years. Fatality cases of patients admitted in April-May 2020, was 70% higher than in the equivalent period of 2019. The month
of May, following the month of April 2020, had the mortality rate of 26.6% among AMI patients admitted to the intensive cardiac care unit, and it was the highest mortality rate among all months in the last 5 years. During the April 2020, the first month of
strict quarantine, in 86,6% (13 out of 15)of AMI patients admitted to ICCU used narcotic analgesics to relieve pain. In May, narcotic analgesics for pain relief were used in 36.6% or in 11 out of 30 patients.86,6%, the percentage of patients with AMI who received
narcotic analgesics for pain relief in April 2020 was the highest among 15 months, from April 2019 to June 2020. During strict quarantine for to prevent spread of COVID-19 in April-May2020 in Azerbaijan, admissions in April for AMI at intensive care unit of
Research Institute of Cardiology in Baku, Azerbaijan, were significantly reduced, fatality cases among patients admitted with AMI increased in May 2020. |
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|
Georges, JL, Cochet, et al |
Annales de Cardiologie et d'Angeiologie |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study sought to analyse the association of severe forms of COVID-19 and mortality with hypertension and a previous
treatment with ACE inhibitors (ACEI) and angiotensin II receptor blockers (ARB). Prospective follow-up of 433 consecutive patients hospitalised for COVID-19 pneumonia confirmed by PCR or highly probable on clinical, biological, and radiological findings, and
included in the COVHYP study. Age was 63.6 ± 18.7 years, and 40%) were female. At follow-up (mean 78 ± 50 days), 136 (31%) patients had severity criteria (death, 64; intensive care unit, 73; hospital stay > 30 days, 49). Hypertension (55.1% vs 36.7%, P < 0.001)
and antihypertensive treatment were associated with severe COVID-19 and mortality. The association between ACEI/ARB treatment and COVID-19 severity criteria found in univariate analysis (Odds Ratio 1.74, 95%CI 1.14–2.64], P = 0.01) was not confirmed when adjusted
on age, gender, and hypertension (adjusted OR1.13 0.59–2.15], P = 0.72). Diabetes and hypothyroidism were associated with severe COVID-19, whereas history of asthma was not. |
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|
Grech, V, Cuschieri, et al |
Early human development |
Epidemiology| Épidémiologie |
This study was carried out in order to delineate the development of a second wave of COVID-19 cases and deaths due
to lockdown easements in June–July 2020. At global level, both datasets exhibited three distinct time periods. Cases rose to mid-April, plateaued till mid-May then rose again. Almost all of the slopes in these three time periods were statistically significant.
Deaths followed a similar three-part pattern, albeit more pronounced, with values lagging circa one week after new cases and a middle time period when numbers (of deaths) actually decreased, with all periods exhibiting significant slopes. At continent level,
for new cases, Asia rose steadily, Europe is increasing again, the Americas and Africa are declining. Deaths follow a similar pattern. Oceania shows a bimodal pattern, with a first and second wave of cases shortly followed by deaths in a similar pattern. The
monthly ratio of detected cases to deaths (case fatality ratio) initially rose to 0.08, then fell to 0.02. |
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Melanoma Diagnostic Delay: Quantitative and Qualitative Measurement
of COVID-19 Lockdown Effect |
Gualdi, Giulio, Porreca, et al |
SSRN- Lancet prepublication |
Healthcare Response | Réponse des soins de santé |
We aimed to examine the impact of the reduction of ordinary dermatologic face‐to‐face consultations activities on melanoma
progression during COVID-19 Pandemic lock down. Reduction of a timely adequate diagnosis and treatment of melanoma during lockdown in Italy has lead to a significative increase of the severity of melanomas. |
|
Han, Qizheng, Wang, et al |
SSRN- Lancet prepublication |
Coronavirology| Coronavirologie |
In this study, we collected open access data to thoroughly analyze the mechanisms associated with SARS-CoV-2 infection.
Gene set enrichment analysis (GSEA) revealed that apoptosis-related pathways were enriched in the cells after SARS-CoV-2 infection, and the results of differential expression analysis showed that biological functions related to endoplasmic reticulum stress
(ERS) and lipid metabolism were disordered. TMBIM6 was identified as a potential target for SARS-CoV-2 in host cells through weighted gene coexpression network analysis (WGCNA) of the time course of expression of host and viral proteins. The expression and
related functions of TMBIM6 were subsequently analyzed to illuminate how viral proteins interfere with the physiological function of host cells. The potential function of viral proteins was further analyzed by GEne Network Inference with Ensemble of trees
(GENIE3). This study identified TMBIM6 as a target protein associated with the pathogenesis of SARS-CoV-2, which might provide a novel therapeutic approach for COVID-19 in the future. |
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Systematic analysis of innate immune antagonism reveals
vulnerabilities of SARS-CoV-2 |
Hayn, Manuel, Hirschenberger, et al |
bioRxiv |
Coronavirology| Coronavirologie Immunology | Immunologie |
We systematically analysed the impact of 29 SARS-CoV-2 encoded proteins on three major arms of our cell-intrinsic innate
immune defences: interferon (IFN) induction, cytokine signalling and autophagy. Subsequent mechanistic analyses revealed that SARS-CoV-2 proteins target the respective signalling cascades at multiple steps. We show that Nsp14 reduces endogenous IFN receptor
levels and ORF3a and ORF7a perturb the late endosomal/trans-Golgi network. Our data demonstrates that most antagonistic activities are conserved between proteins encoded by SARS-CoV-2, the closely related bat RaTG13-CoV and the highly pathogenic SARS-CoV-1.
However, SARS-CoV-1 Nsp15 is strikingly more potent in suppressing IFN induction and signalling than its SARS-CoV-2 counterpart. This may help explain the lower pathogenicity of SARS-CoV-2, which facilitated its rapid spread. Overall our analyses revealed
that IFN-γ and IFN-λ1 signalling are antagonised the least, leaving SARS-CoV-2 highly susceptible to these two cytokines. Their combination synergistically potentiated the anti-viral effects against SARS-CoV-2 at low concentrations. Taken together, our results
allow an explanation for differences in susceptibility towards IFNs and provide evidence that rational immune activation may be an effective future therapeutic strategy against SARS-CoV-2. |
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COVID-19 and emergency department volume: The patients return but have different
characteristics |
Heppner, Z, Shreffler, et al |
American Journal of Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to determine the impact of COVID-19 on emergency department (ED) metrics. Despite relatively
low local prevalence of COVID-19, authors report decreases in ED volume for some medical diagnosis categories. |
|
Holzgreve, A, Fabritius, et al |
Diagnostics |
Clinical data| Données cliniques |
A 42-year old male patient presented with sudden respiratory insufficiency during arthroscopic knee lavage and subsequently
required highly invasive ventilation therapy and catecholamine administration. Postoperative CT imaging of the thorax exhibited extensive, centrally accentuated consolidations with surrounding ground-glass opacity in all lung lobes, suggestive of pulmonary
edema. In view of the clinical course and the imaging findings, a negative pressure pulmonary edema (NPPE) was diagnosed. |
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Hou, TY, Dong, et al |
Academic Journal of Second Military Medical University |
Public Health response| Interventions de santé publique |
This study aims to explore the panic state and related influencing factors among military personnel during the early
epidemic stage of coronavirus disease 2019 (COVID-19). In the early stage of the COVID-19 epidemic, 431 officers and soldiers stationed in Hebei were randomly selected by the cluster sampling method and investigated with psychological stress self-evaluation
test (PSET), self-rating anxiety scale, and self-designed questionnaires regarding the knowledge of COVID-19, sources of psychological panic scale, evaluation scale of various information released and risk perception scale. A total of 411 valid questionnaires
were collected, with an effective rate of 95.36%. The results showed that 5.84% (24/411) of the officers and soldiers were in psychological stress state and 4.14% (17/411) in psychological panic state. During the early stage of COVID-19 epidemic, factors such
as risk perception and the sources of psychological panic can affect the psychological panic among military personnel. During the CVOID-19 epidemic, corresponding measures should be taken to prevent the psychological panic among the officers and soldiers. |
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Mass Flow Analysis of SARS-CoV-2 for quantified COVID-19 Risk Analysis |
Huppes, Gjalt, Huele, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Transmission |
Several transmission routes of SARS-2 from emission by a person to exposure of another person have been modelled and
quantified. The first route covers closed spaces, with an emission, concentration, and decay model quantifying exposure. A next set of routes covers person-to-person contacts mostly in open spaces, modelling the spatial distribution of exhales towards inhalation.
Closed rooms, poor ventilation, and close person-to-person contact of long duration constitute major exposure risks. |
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Unsupervised explainable AI for molecular evolutionary study of forty thousand
SARS-CoV-2 genomes |
Ikemura, Toshimichi, Wada, et al |
Research Square prepub |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
We previously established unsupervised AI, a BLSOM (batch-learning SOM), which can analyze five million genomic sequences
simultaneously. The present study applied the BLSOM to the oligonucleotide compositions of forty thousand SARS-CoV-2 genomes. While only the oligonucleotide composition was given, the obtained clusters of genomes corresponded primarily to known main clades
and internal divisions in the main clades. Since the BLSOM is explainable AI, it reveals which features of the oligonucleotide composition are responsible for clade clustering. The BLSOM has powerful image display capabilities and enables efficient knowledge
discovery about viral evolutionary processes. |
|
Iyer, V, Wartman, et al |
Brain and Human Body Modeling 2020: Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting |
Coronavirology| Coronavirologie |
In this study, we demonstrate the ability of the boundary element fast multipole method (BEM-FMM) to perform electrical
modeling of a rather complicated microbiological surface topology in a reasonable amount of time. As an example, we consider a Computer Aided Design (CAD)-based SARS-CoV-2 spike glycoprotein structure. This structure is crucial to the mechanism by which the
coronavirus attaches to a target object. Only classic DC steady-state modeling has been performed, in an isotropic continuous medium. |
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Jakovljević, I, Štrukil, et al |
Air Quality, Atmosphere and Health |
Public health interventions*| Interventions de santé publique |
In this study, mass concentrations of the PM1 particle fraction (particulate matter with an equivalent aerodynamic
diameter < 1 μm) and polycyclic aromatic hydrocarbons (PAHs) in PM1 and NO2 were measured. Our results show a concentration decrease by 35% for NO2 and PM1 particles and by 26% for total PAHs at the traffic measuring site. At the residential measuring site,
only concentrations of NO2 decreased slightly, but PM1 particles and PAHs were similar to the year before. |
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Jarynowski, Andrzej, Wojta-Kempa, et al |
medRxiv |
Epidemiology| Épidémiologie |
Our task is to examine the relationship between the SARS-CoV-2 arrival and the number of confirmed COVID-19 cases in
the first wave (period from March 4 to May 22, 2020), and socio-economic variables at the powiat (county) level (NUTS-4) using simple statistical techniques such as data visualization, correlation analysis, spatial clustering and multiple linear regression.
We showed that immigration and the logarithm of general mobility is the best predictor of SARS-CoV-2 arrival times, while emigration, industrialization and air quality explain the most of the size of the epidemic in poviats. On the other hand, infection dynamics
is driven to a lesser extent by previously postulated variables such as population size and density, income or the size of the elderly population. Our analyses could support Polish authorities in preparation for the second wave of infections and optimal management
of resources as we have provided a proposition of optimal distribution of human resources between poviats. |
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Multiplexed proteomics and imaging of resolving and
lethal SARS-CoV-2 infection in the lung |
Kalocsay, Marian, Maliga, et al |
bioRxiv |
Clinical data| Données cliniques Animal model | Modèle animal |
In this study, we describe the combined use of multiplexed deep proteomics with multiplexed imaging to profile infection
and its sequelae directly in fixed lung tissue specimens obtained from necropsy of infected animals and autopsy of human decedents. We characterize multiple steps in disease response from cytokine accumulation and protein phosphorylation to activation of receptors,
changes in signaling pathways, and crosslinking of fibrin to form clots. Our data reveal significant differences between naturally resolving SARS-CoV-2 infection in rhesus macaques and lethal COVID-19 in humans. The approach we describe is broadly applicable
to other tissues and diseases. |
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Kanbarkar, N, Mishra, et al |
Advances in Traditional Medicine |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Phytochemicals from Camellia sinensis were retrieved from the database and identified based on their ability to inhibit
matrix metalloproteinase (MMPs) against SARS-CoV-2 main protease. Theaflavin and Epigallocatechin 3-gallate have not revealed any side effects and these polyphenolic compounds had a strong binding affinity with hydrogen bonds and a good drug-likeness score. |
|
|
Katris, C |
Expert Syst Appl |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The aim of this paper is the generation of a time-series based statistical data-driven procedure in order to track
an outbreak. Time series models were used to predict the evolution of reported cases and included Exponential Smoothing and ARIMA approaches from the classical models, also Feed-Forward Artificial Neural Networks and Multivariate Adaptive Regression Splines
from the machine learning toolbox. Combinations include simple mean, Newbolt-Granger and Bates-Granger approaches. Finally, the tSIR model and the R(0) ratio are used for estimating the spread and the reversion of the pandemic. The suggested procedure is used
to track the COVID-19 epidemic in Greece. |
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Kim, SC, Kong, et al |
American Journal of Emergency Medicine |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
This study evaluated the effectiveness of the negative pressure isolation stretcher (NPIS) and additional negative
pressure isolation rooms (NPIRs) on the maintenance of emergency care capacity during the COVID-19 outbreak. After the intervention, average frequency of medical cessation was significantly decreased from 1.6 times per day (range 0–4) in the pre-intervention
period to 0.6 times per day (range 0–3) in the post-intervention period (p-value <0.01). On the other hand, the number of patients visiting the ED increased significantly from 67.2 persons per day (range 58–79) pre-intervention to 76.3 persons per day (range
61–88) post-intervention (p value <0.01). However, there were no statistically significant differences in the average ED length of stay across the study phases (p value = 0.50). |
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Resilience and demographic characteristics predicting distress during the
COVID-19 crisis |
Kimhi, S, Marciano, et al |
Social Science and Medicine |
Public Health response| Interventions de santé publique |
Investigated the extent to which individual resilience, well-being and demographic characteristics may predict two
indicators of Coronavirus pandemic: distress symptoms and perceived danger. Significant negative correlations were found between individual/community resilience and sense of danger and between individual/community resilience and distress symptoms. Significant
positive correlations were found between gender, community size, economic difficulties and sense of danger. Gender and economic difficulties also positively correlated with distress symptoms. The most highly predictive indicators were the two psychological
characteristics, individual resilience, and well-being. Age, gender, community size, and economic difficulties due to COVID-19 further add to predicting distress, while community and national resilience do not. |
|
Kiti, Moses Chapa, Aguolu, et al |
medRxiv |
Public Health response| Interventions de santé publique |
The study aimed to characterize the patterns of social contacts and mixing across workplace environments, including
on-site or when teleworking. This was a cross-sectional non-probability survey that used standardized social contact diaries to collect data. Employees were requested to record their physical and non-physical contacts in a diary over two consecutive days,
documented at the end of each day. Data were collected from April to June 2020 from two multinational consulting companies and one university, in Georgia. 304 completed both days of contact diary. There was a median of 2 contacts (IQR: 1-4, range: 0-21) per
respondent on both day one and two. The majority (55%) of contacts involved conversation only, occurred at home (64%), and cumulatively lasted more than 4 hours (38%). Most contacts were repeated, and within same age groups, though participants aged 30-59
years reported substantial inter-generational mixing with children. Participating employees in 3 surveyed workplaces reported few contacts, similar to studies from the UK and China when shelter-in-place orders were in effect during the pandemic. Many contacts
were repeated which may limit the spread of infection. Future rounds are planned to assess changes in contact patterns when employees resume work in the office after the lockdown due to COVID-19 pandemic. |
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Kuchhal Dr, Vaibhav, Ahmad Dr, et al |
Research Square prepub |
Clinical data| Données cliniques |
This aim of this paper is to study the status of ear, nose and throat in the patients diagnosed with the CoViD-19.
Among ENT manifestations throat symptoms were found most common including loss of taste in 74 pt. It was noticed that most commonly sweet and salt goes first then sour taste vanish and bitter and chilli taste goes in the end, most of them were reversible after
2-3 weeks. Among nasal symptoms nasal congestion was found most common (72 pt) followed by loss of smell (88 pt), nasal blockage (66 pt) & runny nose (47 pt). loss of smell was also reversible in most of the cases after 2-3 weeks. Ear symptoms were not so
commonly found. Although itching in bilateral ear, sensation of ear fullness, ear ache and conductive hearing loss were complained by some patients. |
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|
Ladhani, SN, Chow, et al |
Journal of Infection |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
In July 2020, Public Health England (PHE) was informed of two asymptomatic staff and one asymptomatic resident in the
same care home who tested positive for SARS-CoV-2 through national screening. The three individuals had all had a history of COVID-19 like symptoms during March-April 2020, had subsequently repeatedly tested negative for SARS-CoV-2 RNA during the weekly local
nasal swab screening during May-June 2020 and were seropositive for SARS-CoV-2 antibodies in June 2020. The reporting of three positive results in a single care home was, therefore, unexpected and prompted additional investigations, which included repeat swabs
that were all negative, and blood sampling which confirmed their seropositivity at the time of re-testing. The lack of an antibody rise four weeks later confirmed that these detections were not new infections and, therefore, false positive screening tests. |
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Predictive Factors for a New Positive Nasopharyngeal
Swab Among Patients Recovered From COVID-19 |
Landi, F, Carfì, et al |
American Journal of Preventive Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study is to identify the potential risk factors associated with persistent positive nasopharyngeal
swab real-time reverse transcription‒polymerase chain reaction tests in a large sample of patients who recovered from COVID-19. After the acute phase of SARS-CoV-2 epidemic infection, the Fondazione Policlinico A. Gemelli IRCSS of Rome established a post-acute
care service for patients discharged from the hospital and recovered from COVID-19. Between April 21 and May 21, 2020, a total of 137 individuals who recovered from COVID-19 were enrolled in this study. All patients were tested for the SARS-CoV-2 virus with
nucleic acid RT-PCR tests. Analysis was conducted in June 2020. Of the 131 patients who repeated the nasopharyngeal swab, 22 patients (16.7%) tested positive again. Some symptoms such as fatigue (51%), dyspnea (44%), and coughing (17%) were still present in
a significant percentage of the patients, with no difference between patients with a negative test and those who tested positive. The likelihood of testing positive for SARS-CoV-2 infection was significantly higher among participants with persistent sore throat
(prevalence ratio=6.50, 95% CI=1.38, 30.6) and symptoms of rhinitis (prevalence ratio=3.72, 95% CI=1.10, 12.5). This study is the first to provide a given rate of patients (16.7%) who test positive on RT-PCR test for SARS-CoV-2 nucleic acid after recovering
from COVID-19. |
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Destructive pulmonary fibrosis after severe COVID-19 pneumonia |
Letellier, A, Gibelin, et al |
International Journal of Infectious Diseases |
Clinical data| Données cliniques |
Case report of a 65-year-old man was admitted to the ICU of Tenon hospital, in Paris, France, for severe confirmed
COVID-19 pneumonia, and who developed fatal pulmonary fibrosis. |
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Coagulopathy of patients with covid-19 is associated with infectious and inflammatory
markers |
Long, X, Zhang, et al |
Risk Management and Healthcare Policy |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Derangement of coagulation and markers of infection and inflammation induced by SARS-CoV-2 infection, as well as their
correlations were elucidated. Methods: One hundred eight ICU patients with COVID-19 in Tongji hospital and Wuhan Jinyintan hospital, in Wuhan, China were included. Results: SARS-CoV-2-associated coagulopathy occurred in most cases of critical illness. Raised
values of d-dimer and FDP were measured in all patients, especially in non-survivors, who had longer PT, APTT, INR, as well as TT, and lower PTA and AT compared to survivors. SIC and DIC mostly occurred in non-survivors. Prothrombotic state, SIC, and DIC are
the characteristics of coagulation in ICU patients with COVID-19. CRP, ESR, serum ferritin, IL-8, IL-2R, IL-6, and PCT were stimulated by SARS-CoV-2 infection. CRP, PCT, serum ferritin, and IL-2R indicate the coagulopathy severity of patients with COVID-19. |
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López Pérez, V, Cora Vicente, et al |
Revista espanola de anestesiologia y reanimacion |
Clinical data| Données cliniques |
This is a case study of a 24-year-old pregnant woman with no history of note who was admitted with a diagnosis of bilateral
pneumonia caused by the coronavirus. She required urgent cesarean section with general anaesthesia and intubation for decubitus intolerance due to the worsening of her symptoms. After extubation, she presented altered mental state that required a differential
diagnosis of encephalitis/meningitis secondary to SARS-CoV-2. CT and CT-angiography were normal, spinal fluid tests were non-specific, and magnetic resonance imaging reported posterior reversible encephalopathy syndrome (PRES) secondary to gestational hypertension.
Eleven days after the cesarean section the patient began to develop hypertension that required treatment. In pregnant SARS-CoV-2 patients, the differential diagnosis of hypertension and altered mental state is often extremely complicated because complementary
tests can be normal and there is no immediate sign of peripartum hypertension. |
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|
Lu, Bo, Yan, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We performed unbiased metatranscriptomic analysis of clinical samples from COVID-19 patients using a newly-developed
RNA-seq library construction method (TRACE-seq), which utilizes tagmentation activity of Tn5 on RNA/DNA hybrids. This approach avoids the laborious and time37 consuming steps in traditional RNA-seq procedure, and hence is fast, sensitive and convenient. |
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Lum, E, Bunnapradist, et al |
Transplantation proceedings |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We reviewed the clinical experience of kidney transplant recipients diagnosed with severe acute respiratory syndrome
coronavirus 2 infection in order to understand the impact of the current COVID-19 pandemic infection on transplant recipients. We sought to evaluate outcomes at a center with a high burden of cases but not experiencing acute crisis due to COVID-19. In this
single center retrospective observational study, medical records of all kidney transplant recipients at the UCLA Medical Center were reviewed for a diagnosis of COVID-19 by polymerase chain reaction, followed by chart review to determine kidney transplant
characteristics and clinical course. A total of 41 kidney transplant recipients were identified with COVID-19 positive polymerase chain reaction. Recipients had been transplanted for a median of 47 months before diagnosis. The large proportion of infected
individuals were minorities (Hispanic 65.9%, black 14.6%), on prednisone, tacrolimus, and mycophenolate mofetil (95.1%, 87.8%, and 87.8%, respectively), and had excellent allograft function (median 1.25 mg/dL). The most common presenting symptoms were fever,
dyspnea, or cough. Most patients were hospitalized (63.4%); mortality was 9.8% and occurred only in patients in the intensive care unit. The most common treatment was reduction or removal of antimetabolite (77.8%). Approximately 26.9% presented with AKI. |
|
|
Evidence of antigenic imprinting in sequential Sarbecovirus
immunization |
Lv, Huibin, So, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins Immunology | Immunologie Animal model |
Modèle animal |
This study provides evidence for antigenic imprinting in Sarbecovirus, which is the subgenus that SARS-CoV-2 belongs
to. Specifically, we sequentially immunized mice with two antigenically distinct Sarbecovirus strains, namely SARS-CoV and SARS-CoV-2. We found that the neutralizing antibodies triggered by the sequentially immunization are dominantly against the one that
is used for priming. |
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More meat, more covid-19 cases? comparative study between
usa and china in importing mutton |
Mafruchati, M |
Systematic Reviews in Pharmacy |
Epidemiology| Épidémiologie |
This study has a purpose to observe if there is a correlation between meat consumption and the number of COVID cases
in the USA and China. This study is a quantitative type method with secondary data as a sample. The result shows that the total import number of mutton does not have any negative impact on COVID cases. |
|
The
role of tocilizumab in treatment of a patient with COVID-19: A case report |
Maleh, PA, Latifi, et al |
Journal of Cellular and Molecular Anesthesia |
Clinical data| Données cliniques |
A 52-years old diabetic man with COVID-19 was admitted to Ayatollah Rouhani Hospital Babol, Iran. After 12 days of
hospitalization and treatment, with respiratory distress and oxygen saturation level to 60%, he was transferred to the intensive care unit. After receiving a 400 mg dose of actemra or tocilizumab, the patient became severely dehydrated and the oxygen saturation
level reached over 90% within a few hours, and 8 days after receiving tocilizumzb (TCZ; Actemra), the patient was suffering from complications of pneumonia. |
|
Martinelli, Domenico, Fortunato, et al |
Research Square prepub |
Epidemiology| Épidémiologie |
We conducted a retrospective epidemiological study to characterize asymptomatic COVID-19 cases occurred in the Apulia
region, Italy, during the first epidemic wave of COVID-19 outbreak. Between February 29 and July 7, 2020, a total of 4,536 cases were diagnosed with COVID-19 among 193.757 tests performed. The group of persons with asymptomatic SARS-CoV-2 infection consisted
of 903 cases; the asymptomatic proportion was 19.9% (95%CI: 18.8-21.1%); this decreased with increasing age (OR: 0.89, 95%CI: 0.83-0.96; p=0.001), in individuals with underlying comorbidities (OR: 0.55, 95%CI: 0.41-0.73; p<0.001), and males (OR: 0.69, 95%CI:
0.54-0.87; p=0.002). The median asymptomatic infectious period was 19 days (IQR: 14-31) and the cumulative proportion of persons with resolution of infection 14 days after the first positive PCR test was 74%. |
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Sudden cardiac arrest in COVID-19 young patient: A case report |
Massoudi, N, Soleimanzadeh, et al |
Journal of Cellular and Molecular Anesthesia |
Clinical data| Données cliniques |
This report contains a summary of a young patient positive for SARs-CoV-2, with a history of methadone intake, which
experienced a cardiopulmonary arrest while he was preparing to take a lung CT scan in an outpatient setting. After a successful Cardio-Pulmonary Recovery in the CT scan room he was admitted in Intensive Care Unit. He had a prolonged QTc interval in Electrocardiograph
and bilateral pulmonary involvement in Chest X-Ray. |
|
Mathiasen, VD, Oversoe, et al |
Transplantation proceedings |
Clinical data| Données cliniques |
We describe a moderate course of coronavirus disease 2019 (COVID-19) in a patient who underwent a liver transplant
2 years earlier because of Budd-Chiari syndrome. The patient presented with malaise, headache, dry cough, and fever for 4 days. Immunosuppressive therapy with tacrolimus and mycophenolate mofetil was continued throughout the course of infection. Oxygen therapy
was given for a single night, and the patient gradually recovered with supportive care only. With this case report, we demonstrate that liver transplantation and immunosuppression is not necessarily associated with severe COVID-19 and emphasize that more information
on this matter is urgently required. Withdrawal of immunosuppressive therapy could be associated with higher mortality. |
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Minniti, CaterinaP, Zaidi, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aim to identify predictors of outcomes and survival in a large US-based SCD and COVID-19 cohort to inform best approaches
to prevention and care. Methods: Clinical data were collected at baseline and during the clinical course using a standardized form in SCD patients diagnosed with COVID-19 at 5 academic centers in four COVID-19 epicenters. Patients were followed post-hospital
discharge for up to 3 months. Results: Of 66 consecutive SCD patients with COVID-19, 75% required hospitalization, with a median length of stay of 6 days, and 7 died (10.6%). Patients with preexisting kidney disease were more likely to be hospitalized, while
age, sex and genotype had no effect. The most common presenting symptom was vaso-occlusive pain. Conclusions: Patients with SCD and COVID-19 infection demonstrated a broad range of disease severity, from mild to very severe. COVID-19 in SCD individuals with
pre-existing cardiopulmonary, renal disease and/or stroke presenting with pain and high creatinine should be considered at risk of death, irrespective of genotype or gender. |
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|
Misa, NY, Perez, et al |
American Journal of Emergency Medicine |
Epidemiology| Épidémiologie |
This study aimed to examine racial and ethnic disparities in test positive rate and mortality among emergency department
(ED) patients tested for COVID-19 Northern California. In this retrospective study we analyzed data from patients seen at three EDs and tested for COVID-19 between April 6 through May 4, 2020. The primary outcome was the test positivity rate by race and ethnicity,
and the secondary outcome was 30 day in-hospital mortality. We used multivariable logistic regression to examine associations with COVID-19 test positivity. There were 526 patients tested for COVID-19, of whom 95 (18.1%) tested positive. The mean age of patients
tested was 54.2 years, 54.7% were male, and 76.1% had at least one medical comorbidity. Black patients accounted for 40.7% of those tested but 16.8% of the positive tests, and Latinx patients accounted for 26.4% of those tested but 58.9% of the positive tests.
The test positivity rate among Latinx patients was 40.3% (56/139) compared with 10.1% (39/387) among non-Latinx patients (p < 0.001). Latinx ethnicity was associated with COVID-19 test positivity (adjusted odds ratio 9.6, 95% confidence interval: 3.5–26.0).
Mortality among Black patients was higher than non-Black patients (18.7% vs 1.3%, p < 0.001). We report a significant disparity in COVID-19 adjusted test positivity rate and crude mortality rate among Latinx and Black patients, respectively. |
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|
Möckel, Martin, Stegemann, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques |
Authors retrieved all patients who were treated at the ED of the Charité (Berlin, Germany) during the pandemic peak
between March 1 and April 15, 2020 and who underwent SARS-CoV-2 testing using an oro-naso-pharyngeal swab. Based on easily available variables like dyspnea, oxygen saturation, history of cardiovascular disease, approximately 25% of patients subsequently confirmed
with COVID-19 can be identified for safe discharge. |
|
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Carotane sesquiterpenes fromFerula vesceritensis:in silicoanalysis as SARS-CoV-2 binding
inhibitors |
Mohamed, TA, Elshamy, et al |
RSC Advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Two sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol
(2) as well as, ten known analogues (3-10), and two sesquiterpene coumarins (11-12) were isolated from an organic root extract of Ferula vesceritensis(Fam. Apiaceae). Chemical structures were elucidated based on IR, 1D- and 2D-NMR and HRMS, spectroscopic analyses.
With molecular overlap observed between two protease inhibitors that are being examined as anti-COVID-19 drugs, and sesquiterpenes isolated here, metabolite molecular docking calculations were made using the main protease (Mpro), which is required for viral
multiplication as well as RNA-dependent RNA polymerase (RdRp).In silico binding-inhibition analysis predicted that selectF. vesceritensissesquiterpenes can bind to these enzymes required for viral replication. Structures of the isolated constituents were also
consistent with the chemo-systematic grouping ofF. vesceritens is secondary metabolites with other Ferulaspecies. |
|
Myocardial injury in a patient with severe coronavirus disease: A case report |
Nakamura, Y, Shimizu, et al |
Journal of Infection and Chemotherapy |
Clinical data| Données cliniques |
We present a case of a patient with COVID-19 who died soon after developing multi-organ failure and myocardial injury
due to COVID-19-associated pneumonia. A 71-year-old man who contracted COVID-19 was admitted to the hospital after presenting with fever for 7 days and developed dyspnea. Following treatment, his respiratory status worsened. Thus, he was transferred to our
hospital for intensive care on day 11. Physical examination revealed fever, dyspnea, respiratory distress, and no chest pain. Invasive positive pressure ventilation was initiated for acute respiratory distress syndrome on day 14. On day 15, we observed renal,
liver, and coagulation dysfunction, indicating multi-organ failure. Chest radiography did not show clear signs of an increased cardiothoracic ratio or pulmonary congestion. An electrocardiogram (ECG) showed signs of myocardial infarction, which was confirmed
by elevated troponin I and creatine kinase levels. The patient's circulatory dynamics did not improve on medication, and he died on day 16. |
|
Foot manifestations in a patient with COVID-19 and Epstein-Barr virus: A case study |
Nirenberg, MS, Herrera, et al |
Foot |
Clinical data| Données cliniques |
The authors present a case study chronicling the progression of foot issues in a COVID-19 positive patient who also
was positive for the Epstein-Barr virus. |
|
Olivar-López, V, Leyva-Barrera, et al |
Boletin medico del Hospital Infantil de Mexico |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Methods: We conducted an analytical cross-sectional study of symptoms suggestive for SARS-CoV-2 infection. All subjects
with a confirmatory test for SARS-CoV-2 were included. Initial symptoms, history of influenza vaccination, and previous contact were documented, and mortality and the requirement for assisted mechanical ventilation were identified. Results: Of a total of 510
subjects, 76 (15%) were positive for SARS-CoV-2. The associated symptoms were chest pain, sudden onset of symptoms, and general malaise. The variable most associated with contagion was the exposure to a relative with a confirmed diagnosis of COVID-19. Infants
and subjects without the influenza vaccine showed an increased risk for respiratory complications. |
|
|
Padhi, S, Suvankar, et al |
Transfusion Clinique et Biologique |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study performed an epidemiological investigation in the Indian population to decipher the importance of blood
groups concerning susceptibility or mortality in COVID-19 infection. A significant inverse correlation was observed between the frequency of O blood group and the COVID-19 mortality rate (Spearman r = −0.36, P = 0.03), indicating a possible protective role
of O blood group against COVID-19 related death. In contrast, the prevalence of blood group B was positively correlated with COVID-19 death/million (Spearman r = 0.67, P < 0.0001), suggesting B blood type as a deleterious factor in COVID-19 infection. |
|
|
Páez-Franco, JoséC, Torres-Ruíz, et al |
Research Square prepub |
Clinical data| Données cliniques |
We identified the main changes in serum metabolites associated with severe (n=46) and mild (n=19) COVID-19 patients
by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three |
|
|
Pagani, G, Conti, et al |
Journal of Infection |
Epidemiology| Épidémiologie Immunology | Immunologie |
Estimated SARS-CoV-2 seroprevalence in the municipality of Castiglione d'Adda, a rural town of about 4550 inhabitants
located South-East of Milan, which has been heavily affected by SARS-CoV-2 infection since the earliest stages of the epidemic. 509 people were selected in the random sample who agreed to undergo venipuncture to perform CLIA serologies. The overall seroprevalence
found in the tested sample was 22.6%. Findings also suggest that SARS-CoV-2 IgG seroprevalence increases with increasing age and these data suggest a lower susceptibility to infection in the lower age groups. |
|
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Repurposed antiviral drugs for COVID-19; interim
WHO SOLIDARITY trial results |
Pan, Hongchao, Peto, et al |
medRxiv |
Therapeutics| Thérapeutique RCT |
Reported mortality trials in hospitalized COVID-19 of four re-purposed antiviral drugs. In 405 hospitals in 30 countries
11,266 adults were randomized, with 2750 allocated Remdesivir, 954 Hydroxychloroquine, 1411 Lopinavir, 651 Interferon plus Lopinavir, 1412 only Interferon, and 4088 no study drug. 1253 deaths were reported (at median day 8). These Remdesivir, Hydroxychloroquine,
Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay. |
|
A Description of COVID-19 Incidence and Outcomes in a Large Tertiary
Paediatric Emergency Department |
Pandey, Meenu, Sisodia, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
This retrospective study aims to analyse the characteristics of SARS-CoV-2 positive children presenting to Paediatric
Emergency Department (PED) of the Leicester Royal Infirmary, to determine patient outcomes and analyse the effectiveness of infection-control procedures. 27 children (0-15 years) tested COVID positive within the hospital. 22 of these presented to the PED
among 10777 presentations. 20/22 patients were admitted, all were eventually discharged. The average LOS of these patients was 120.7 hours. No inter-patient SARS-CoV-2 infection transfer was seen in the ED. Our study demonstrated that children don’t appear
to be causing spread within our PED. Division of PED into two areas meant a substantial change to our working due to changes in staff allocation and challenges to PED leadership. Only a very small number of patients were SARS-CoV-2 positive- this leads us
to believe that the current measures to split the departments are effective, but also perhaps, unnecessary. |
|
Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2 |
Peng, T, Liu, et al |
Applied Physics Letters |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We report a photon-counting approach to accurately quantify lateral flow assays (LFA) while enhancing sensitivity.
In particular, we demonstrate that the density of SARS-CoV-2 antibodies can be quantified and measured with an enhanced sensitivity using this simple laser optical analysis. |
|
Perotte, R, Sugalski, et al |
American Journal of Emergency Medicine |
Clinical data| Données cliniques |
We aim to evaluate the chief complaints of patients presenting to our ED with either suspected or confirmed COVID-19
to better understand the clinical presentation of this pandemic. Methods: This study was a retrospective computational analysis that investigated the chief complaints of all confirmed and suspected COVID-19 cases presenting to our adult ED (patients aged 22
and older) using a variety of data mining methods. Results: Of the 209 chief complaints, fever and shortness of breath were the most prevalent initial presenting symptoms. In the subset of COVID-19 confirmed positive cases, we discovered seven distinct clusters
of presenting complaints. Patients over 65 years of age were more likely to present with weakness and altered mental status. |
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|
Perveen, Sumera, Khalili Yazdi, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here we report the development of a fluorescence polarization (FP)-based RNA displacement assay for nsp10-nsp16 complex
in 384-well format with a Z′-Factor of 0.6, suitable for high throughput screening. This assay provides a cost-effective high throughput method for screening nsp10-nsp16 complex for RNA-competitive inhibitors towards developing COVID-19 therapeutics. |
|
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Severe and treatment-resistant hypocalcemia in patient with bilateral COVID-19
pneumonia |
Pla, B, Silva, et al |
Endocrinologia, Diabetes y Nutricion |
Clinical data| Données cliniques |
Present the case of a 76-year-old man admitted for bilateral pneumonia due to COVID-19. History of hypertension and
chronic hypocalcaemia of unclear cause, on regular treatment. Upon arrival at the emergency room, arterial blood gases are compatible with respiratory failure. The chest radiograph shows extensive bilateral consolidations of peripheral distribution and the
nasopharyngeal exudate is positive for COVID-19. Despite clinical and analytical improvement after initiation of treatment, the patient reported perioral and upper extremity paresthesias. Normalization of calcaemia (ionic calcium in blood gas 4.96 mg / dl)
is achieved , with treatment with progressive oral supplementation up to 3 g of calcium element / day. COVID-19 infection could precipitate a treatment-resistant hypocalcemic crisis in patients with underlying phosphocalcic metabolism disorders, such as our
case of probable asymptomatic hypoparathyroidism previously controlled exclusively with low doses of oral calcium / vitamin D supplements. |
|
Pradhan, Amartya, Saini, et al |
Research Square prepub |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique Immunology | Immunologie |
This study aimed at generating antibody candidates from the human antibody CR3022 (derived from convalescent SARS patient)
against the Receptor binding domain (RBD) of SARS-CoV-2 via in silico affinity maturation. Out of seven antibody leads generated post in silico site-directed mutagenesis followed by preliminary screening, antibody named SAM3 was predicted to have the highest
binding affinity towards RBD. However, molecular dynamics simulation of fifty nanoseconds set the seal on SAM1 and SAM2. Both demonstrated a higher binding affinity and stability compared to other counterparts and CR3022. Hypothesizes that SAM1, SAM2, and
SAM3 antibody candidates can bind to the RBD and potentially disrupt the viral invasion. |
|
|
Qutob, Nouar, Awartani, et al |
medRxiv |
Public Health response| Interventions de santé publique |
To assess the knowledge and practices of Palestinians towards COVID-19 after the ease of movement restrictions, we
collected data from Palestinian adults between June 15th and June 30th 2020. We conclude that the majority of participants have a good knowledge about COVID-19, but were not adequately committed to the infection control measures necessary to protect themselves
and others. |
|
|
Rajendran, S, Jayagopal, et al |
Measurement: Journal of the International Measurement Confederation |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This study determined the impact of lockdown and social distancing in Tamilnadu through epidemiological models in forecasting
the “effective reproductive number” (R0) determining the significance in transmission rate in Tamilnadu after first Covid19 case confirmation on March 07, 2020. Comparing the different epidemiological models (SIR, SIER) in forecasting and assessing the current
and future spread of COVID-19. R0 value has a high spike in densely populated districts with the probable flattening of the curve due to lockdown and the rapid rise after the relaxation of lockdown. As of June 03, 2020, there were 25,872 confirmed cases and
208 deaths in Tamilnadu after two and a half months of lockdown with minimal exceptions. As on June 03, 2020, the information published online by the Tamilnadu state government the fatality is at 1.8% (208/11345 = 1.8%) spread with those aged (0–12) at 1437
and 13–60 at 21,899 and 60+ at 2536 the risk of symptomatic infection increases with age and comorbid conditions. |
|
|
Randall, M, Minahan, et al |
American Journal of Infection Control |
Clinical data| Données cliniques Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
We theorized that the increase in PPE use would decrease nosocomial infections overall. However, within 3 months, 3
inmates from the same local state prison admitted as inpatients to our county hospital for COVID-19 infections, developed nosocomial methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. During this period, one other patient from a skilled nursing
facility also developed nosocomial MRSA bacteremia but was COVID-19 negative. For comparison, prior to the COVID-19 pandemic, the hospital has had no more than 5 nosocomial MRSA bacteremia infections identified in the last 4 years. |
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Randler, C, Tryjanowski, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
Examined the behavioral changes of birders (which is the practice of observing birds based on visual and acoustic cues).
A total of 4484 questionnaire survey responses from 97 countries were received. About 85% of respondents reported that COVID-19 has changed their birding behavior. The most significant change in birdwatchers’ behavior was related to the geographic coverage
of birding activities, which became more local. People focused mostly on yard birding. In total, 12% of respondents reported having more time for birding, whereas 8% reported having less time for birding. Social interactions decreased since respondents, especially
older people, changed their birding behavior toward birding alone or with their spouse. Women reported more often than men that they changed to birding alone or with their spouse, and women also reported more often about canceled fieldtrips or society meetings.
Respondents from higher developed countries reported that they spend currently more time for birding, especially for birding alone or with their spouse, and birding at local hotspots. |
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|
Razjouyan, Javad, Helmer, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective cohort study, we examine the COVID-19 related healthcare utilization and mortality by race and
ethnicity of patients tested for SARS-CoV-2 in the Veterans Health Administration (VHA). The testing rate was 4.4% among Black and 4.7% among Hispanic veterans compared to White veterans, 2.8%. The testing positivity rate was similarly elevated among Black
and Hispanic veterans compared to White veterans. The aORs of hospitalization in Black veterans (1.88; 95% CI 1.74, 2.03) and Hispanic veterans (1.41; 95% CI 1.25, 1.60) were higher compared to White veterans. No significant differences by race and ethnicity
were observed in OR or aOR of ICU admission and in-hospital death among hospitalized patients. This pattern of differences may relate to social determinants of health, implicit biases, or preferences for VHA care affecting initial care seeking, but not in-hospital
outcomes. |
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|
Anxiety and Depression During COVID-19 Pandemic Among Medical Students
in Nepal |
Risal, Ajay, Shikhrakar, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
This study assessed levels of anxiety and depression among medical students during the initial stages of the pandemic
in Nepal and related their distress to psychosocial and other relevant situational variables. A total 416 medical students mean age: 22.2 (2.1); males 57.7%, females 42.3%] participated. HADS-anxiety scores mean: 7.1(4.3)] were significantly and positively
correlated with HADS-depression mean: 5.9 (4.1)] (r=0.695; p22 years (AOR= 2.2, 2.5 and 4.4 respectively). HADS-cAD was almost three-times higher among those with a possible COVID-19 exposure (AOR=2.8). |
|
Rith, M, Piantanakulchai, et al |
Walailak Journal of Science and Technology |
Public Health response| Interventions de santé publique |
The present study intends to understand the at-home activities and well-being of foreign students. A web-based survey
was conducted from March 22-23 March 2020 to record the activities and well-being of the students on March 20-21 2020. Happiness and stress levels with the seven-points Likert scales were considered as the two output variables (1 = lowest and 7 = highest).
The ordered probit model was applied to develop the subjective well-being models, taking into account at-home activities. The results highlighted that students who were happier were more likely to study for longer at home, but that studying for longer increases
stress levels. Students who were less happy and more stressed were more likely to speak on the phone for longer, while doing exercise at home for longer increased the likelihood of happiness. This paper contributes to a better understanding of at-home activities
associated with well-being of foreign students in Thailand during the COVID-19 outbreak. |
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Cytosorb filter: An adjunct for survival in the COVID-19 patient in cytokine
storm? a case report |
Rizvi, S, Danic, et al |
Heart and Lung |
Clinical data| Données cliniques |
The cytokine storm that inflicts some patients can be devastating to the vital organs of the human body in the form
of acute respiratory distress syndrome (ARDS), renal failure, coagulopathy, and death. Cytosorbents® cytokine filter is a potential treatment methodology aimed at reducing the cytokine storm, thus serving as a bridge for therapy in the acutely ill patients
infected with COVID-19. The following case report demonstrates the utility in a critically ill patient who survived the cytokine storm after receiving the cytokine filter via continuous renal replacement therapy bridging him to further definitive therapy. |
|
Clinical evaluation of SARS-CoV-2 point-of-care antibody tests |
Robosa, RS, Sandaradura, et al |
Pathology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The aim of this study was to assess the analytic and clinical performance of four rapid lateral flow point-of-care
tests (POCTs) for identifying SARS-CoV-2-specific antibodies. A retrospective study was conducted between 22 January and 30 March 2020 on 132 serum samples for SARS-CoV-2-specific antibody detection referred to a tertiary referral hospital laboratory in New
South Wales. Multiple sera were tested from 20 confirmed or suspected COVID-19 patients with SARS-CoV-2-specific antibodies detected by immunofluorescence (IFA) or neutralisation, and 71 SARS-CoV-2 uninfected individuals. We measured the sensitivity and specificity
for detection of SARS-CoV-2 IgM and IgG antibodies for each POCT in comparison to positive SARS-CoV-2-specific IFA and viral neutralisation, our current laboratory benchmark tests. All POCTs were found to have a low analytic sensitivity for SARS-CoV-2 antibodies,
ranging from 27.3% to 58.2%, with a specificity between 88.3% and 100%, and a low clinical sensitivity from 45% to 65%, with a clinical specificity between 87.3% and 100%. |
|
Crystal structure of non-structural protein 10 from severe acute respiratory syndrome
coronavirus-2 |
Rogstam, A, Nyblom, et al |
International Journal of Molecular Sciences |
Coronavirology| Coronavirologie |
This study reports the biophysical characterization and 1.6 Å resolution structure of the unbound form of nsp10 from
SARS-CoV-2 and compare it to the structures of its SARS homologue and the complex-bound form with nsp16 from SARS-CoV-2. The crystal structure and solution behaviour of nsp10 will not only form the basis for understanding the role of SARS-CoV-2 nsp10 as a
central player of the viral RNA capping apparatus, but will also serve as a basis for the development of inhibitors of nsp10, interfering with crucial functions of the replication–transcription complex and virus replication. |
|
The Impact of the COVID-19 Lockdown on Urban Street Litter in South Africa |
Ryan, PG, Maclean, et al |
Environmental Processes |
Public Health response| Interventions de santé publique |
We recorded daily litter arrival rates for 50 days in two South African cities from the time of strictest lockdown
through two successive easings in regulations. Street litter loads decreased roughly by a factor of three during the strict lockdown. The increase in litter was gradual, suggesting a reduction in compliance with regulations as the lockdown continued. Our results
show a clear link between human activity levels and littering. |
|
Ryan, Rececca, Taylor, et al |
Research Square prepub |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The objective of this study was to compare differences in indications, management, complications and outcomes of renal
replacement therapy (RRT) in COVID-19 patients compared to non-COVID critically ill patients. The metabolic phenotype in COVID-19 patients requiring RRT differs from non-COVID-19 patients, although outcomes (mortality and renal recovery) are similar. |
|
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Safarpour, D, Srinivasan, et al |
Clinical Lymphoma, Myeloma and Leukemia |
Clinical data| Données cliniques |
We have described the case of a patient with CLL who had developed severe COVID-19 and had presented with marked lymphocytosis
within 2 to 3 days of the COVID-19 diagnosis. |
|
|
Sahu, AK, Mathew, et al |
American Journal of Emergency Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to describe the lung sonographic findings of COVID-19 patients prospectively and investigate
its association with disease severity. The lung sonographic findings of COVID-19 were found more bilaterally and in lower lung zones, and specific findings like B – profile, pleural thickening, spared areas and confluent B – lines or waterfall sign were associated
with severe COVID-19. |
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Saiz Llamosas, JR, Pérez García, et al |
Fisioterapia |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Since there is little existing evidence on the physiotherapy treatment approach, and there are restrictions to usual
consultation, the aim is to check whether Physical Therapy Primary Care (PTPC) intervention through remote consultation is effective. A 47-year-old male patient with Coronavirus pneumonia underwent a physiotherapy intervention through remote consultation (RC)
over the phone 7 days after being discharged. The physiotherapy phone consultation program allowed the treatment and follow up of this patient (physiological variables, SPPB and HRQL) which resulted in improvement. |
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Samrah, SM, Al-Mistarehi, et al |
Psychology Research and Behavior Management |
Public Health response| Interventions de santé publique |
This cross-sectional study aims to evaluate depression, associated stressors, and various coping methods used among
adult quarantined COVID-19-infected individuals. Out of 91 quarantined COVID-19 patients, a total of 66 completed the survey. The mean ± SD age was 35.8 ± 16.2 years (range 18–79), 59.1% were females and 47% were asymptomatic. A considerable proportion of
patients (44%) reported symptoms of depression, with 21% were at high risk of major depressive disorder. Depression symptoms were significantly more common among females than males. The majority of patients (71.2%) reported having problems with health-care
services. Insufficient involvement in making treatment decisions was the most commonly reported concern (59.1%). Patients who reported problems in maintaining privacy, reaching out to their physicians, or receiving conflicting information from the medical
staff, had more symptoms of depression compared with the satisfied ones. On the other hand, those who were receiving sufficient support from the family, friends, or medical staff during quarantine, were less likely to have depression symptoms. Furthermore,
symptoms of depression were less in patients who stayed in touch with others using phone calls, texting, or social media. |
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|
Scharbarg, E, Moog, et al |
Annual Reviews in Control |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Two mathematical models of the COVID-19 dynamics are considered as the health system in some country consists in a
network of regional hospital centers. The first macroscopic model for the virus dynamics at the level of the general population of the country is derived from a standard SIR model. The second local model refers to a single node of the health system network,
i.e. it models the flows of patients with a smaller granularity at the level of a regional hospital care center for COVID-19 infected patients. Daily (low cost) data are easily collected at this level, and are worked out for a fast evaluation of the local
health status thanks to control systems methods. Precisely, the identifiability of the parameters of the hospital model is proven and thanks to the availability of clinical data, essential characteristics of the local health status are identified. Those parameters
are meaningful not only to alert on some increase of the infection, but also to assess the efficiency of the therapy and health policy. © 2020 |
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|
Sharma, R, Shishodia, et al |
International Journal of Logistics Research and Applications |
Economics | Économie |
This study identified and assessed the agricultural supply chains (ASCs) risks caused by disruptions. These threats
were assessed using Fuzzy Linguistic Quantifier Order Weighted Aggregation (FLQ-OWA). The findings reveal that supply risks, demand risks, financial risks, logistics and infrastructure risks, management and operational, policy and regulation, and biological
and environmental risks have a significant impact in ASC depending upon the organisations scope and scale. Various strategies such as adoption of industry 4.0 technologies, supply chain collaboration and shared responsibility is identified for sustainable
future. |
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Radiology Workload Changes During the COVID-19 Pandemic: Implications for Staff
Redeployment |
Shi, J, Giess, et al |
Academic Radiology |
Healthcare Response | Réponse des soins de santé |
The aim of the study is to quantify changes in total and by-subspecialty radiology workload due to deferring nonurgent
services during the initial COVID-19 pandemic, and describe operational strategies implemented due to shifts in priority. This retrospective study was performed between February 3, 2020 and April 19, 2020 at a large academic medical center. During March 9–15
(intervention period), nonurgent outpatient service deferments began. Five-week periods pre- (baseline) and postintervention (COVID) were defined. Primary outcomes were radiology volume (reports per day) overall and in 11 subspecialty divisions. Linear regression
assessed relationship between baseline vs. COVID volumes stratified by division. Secondary outcomes included changes in relative value units (RVUs), inpatient and outpatient volumes. There were 62,791 baseline reports vs. 23,369 during COVID; a 60% overall
precipitous volume decrease (p 75% volume decrease. Total RVUs decreased 60% (71,186 baseline; 28,476 COVID). Both outpatient and inpatient report volumes decreased; 72% (41,115 baseline; 11,326 COVID) and 43% (12,626 baseline vs. 6,845 COVID), respectively.
In labor pool tracking data, 21.8% (162/744) total radiology employees were reassigned to other hospital duties during the intervention period. Precipitous radiology workload reductions impacted subspecialty divisions with marked variation. |
|
Singkun, A, Patiwikriwong, et al |
Walailak Journal of Science and Technology |
Public Health response| Interventions de santé publique |
The objectives of this research were to study the knowledge on COVID-19 infection, satisfaction of the measures on
disease prevention and control, and the association between factors and COVID-19 prevention behaviors among health sciences students. Self-administered questionnaires were used to collect the data of 184 health sciences students in April, 2020. The results
found that participants had correct answer for COVID-19 infection (70.65-99.46 %) and had a good knowledge level on COVID-19 infection (90.22 %). Their satisfaction of the institute’s measures on COVID-19 prevention and control was at High level (50.54 %).
COVID-19 prevention behavior among participants was at moderate level (51.63 %). Age, year level, payment per week, and satisfaction level of their organization’s measures on COVID-19 prevention and control were closely associated with COVID-19 prevention
behavior (p-value < 0.05). |
|
|
Solano-López, J, Zamorano, et al |
Revista espanola de cardiologia |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Describe the clinical presentation, complications, and risk factors for mortality in patients admitted for AMI during
the COVID-19 pandemic. In total, 187 patients were admitted for AMI, 111 with ST-segment elevation AMI and 76 with non-ST-segment elevation AMI. Of these, 32 (17%) were diagnosed with COVID-19. GRACE score, Killip-Kimball classification, and several inflammatory
markers were significantly higher in COVID-19-positive patients. Total and cardiovascular mortality were also significantly higher in COVID-19-positive patients (25% vs 3.8% P 140 (OR, 23.45; 95%CI, 2.52–62.51; P =.005) and COVID-19 (OR, 6.61; 95%CI, 1.82-24.43;
P =.02) were independent predictors of in-hospital death. |
|
|
Sui, Y, Zhang, et al |
Applied Energy |
Public Health response| Interventions de santé publique |
This paper provides a method framework for analyzing spatio-temporal emission patterns of buses in combination with
real-time ridership and potential emission changes in the post-COVID-19 future. 224 social surveys are collected and show a 56.3% ridership reduction in post-COVID-19. We conclude that when ridership reduces by more than 40%, buses cannot be “greener” travel
modal than cars as before. |
|
|
Examining
organizational response and employee coping behaviors amid the COVID-19 pandemic |
Teng-Calleja, M, Caringal-Go, et al |
Journal of Behavioral Science |
Public Health response| Interventions de santé publique |
The study examined organizational responses and individual employee coping behaviors to mitigate the impact of the
COVID-19 pandemic. Qualitative data were gathered through online survey from 216 employees in the Philippines. The study identified organizational actions or responses to help employees adapt to the COVID-19 crisis. These are: 1) flexible work arrangements,
2) mental health and well-being programs, 3) physical health and safety measures, 4) financial support, 5) provision of material resources, and 6) communication of short and long term plans. Findings also surfaced coping strategies at the individual employee
level and how these relate to organizational initiatives. Seven themes emerged from the data-1) task-focused coping, 2) stress management, 3) social coping, 4) cognitive strategies, 5) learning and development activities, 6) faith-oriented coping, and 7) maladaptive
strategies. The analysis highlighted the interrelatedness of organizational responses and employee actions (e.g. how individual task/social coping behaviors were enabled by the company's flexible work arrangements and provision of technological resources amidst
physical distancing). |
|
Theuerkauf, SamuelA, Michels, et al |
bioRxiv |
Coronavirology| Coronavirologie |
This article describes the quantitative assay systems covering not only particle-cell and cell-cell fusion, but also
demonstrating fusion-from-without (FFWO), the formation of syncytia induced by S-containing viral particles in absence of newly synthesized S protein. Based on complementation of split β-galactosidase and virus-like-particles (VLPs) displaying S protein, this
assay can be performed at BSL-1. All three assays provided readouts with a high dynamic range and signal-to-noise ratios covering several orders of magnitude. The data obtained confirm the enhancing effect of trypsin and overexpression of angiotensin-converting
enzyme 2 (ACE2) on membrane fusion. Neutralizing antibodies as well as sera from convalescent patients inhibited particle-cell fusion with high efficiency. Cell-cell fusion, in contrast, was only moderately inhibited despite requiring much lower levels of
S protein, which were below the detection limit of flow cytometry and Western blot. The data indicate that syncytia formation as a pathological consequence in tissues of Covid-19 patients can proceed at low levels of S protein and may not be effectively prevented
by antibodies.Competing Interest StatementThe authors have declared no competing interest. |
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Dishonesty and mandatory mask wearing in the COVID-19 pandemic |
Tobol, Y, Siniver, et al |
Economics Letters |
Public Health response| Interventions de santé publique |
The present paper reports the results of a field experiment designed to examine the hypothesis that, given the opportunity,
passersby who wear their mask around their chin or neck are more likely to lie than those who wear no mask at all, although intuition may suggest otherwise. Incentivizing passersby’s dishonesty with the Die-Under-the-Cup (DUCT) task, the experiment results
support our hypothesis. |
|
Trunfio, M, Salvador, et al |
Thrombosis research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This editorial reports on the SARS-CoV-2-positive patients admitted to and dead/discharged from sub-intensive unit
of Infectious Diseases in an Italian hospital between March–May 2020 to assess whether the application of a clinically driven anti-Xa monitoring may have associated with the disease outcomes: deaths from overall causes, COVID-19-related deaths and thrombotic
events. 56 patients were included: 64.3% were male; the median age, BMI and serum creatinine were 67 years (59–80), 24.5 (21.9–26.5) and 1.0 mg/dL (0.86–1.22), respectively. At admission, 49 patients (87.5%) were on once-daily prophylactic enoxaparin (44 patients;
median 4000 IU/dose [4000–6000]) or parnaparin (5 patients; median 4000 IU/dose [4000–4000]), while 7 patients (12.5%) were on twice daily enoxaparin (median 6000 IU/dose [4000–6000]) due to atrial fibrillation. 3 pulmonary emboli, 1 deep vein thrombosis and
1 retinal vein occlusion were observed and 9 deaths occurred. Among the latter, 5 were directly attributable to COVID-19 (1 pulmonary embolus, 3 respiratory failure due to severe viral pneumonia, 1 hypoxic myocardial infarction); no major bleeding was observed.
Observed a significantly elevated prevalence of patients failing to achieve an effective anti-Xa activity (41.3%); this value sits in between the prevalence previously reported in ICU and normal wards, leading to hypothesize a positive correlation between
the disease severity and hampered heparin effectiveness. |
|
|
Turcotte, B, Paquet, et al |
Canadian Urological Association Journal |
Healthcare Response | Réponse des soins de santé |
The aim of the study was to determine the percentage of outpatient urological cases that could be managed completely
by telemedicine outside of the COVID-19 pandemic. This prospective, multisite study involved all urologists working in the region of Quebec City. During the first four weeks of the regional confinement, 18 pediatric and adult urologists were asked to determine,
after each telemedicine appointment, if it translated into a complete (CCM), incomplete (ICM), or suboptimal case management (SCM, adequate only in the context of the pandemic). A total of 1679 appointments representing all urological areas were registered.
Overall, 67.6% (95% confidence interval CI] 65.3; 69.8), 27.1% (25.0; 29.3), and 4.3% (3.5; 5.4) were reported as CCM, SCM, and ICM, respectively. The CCM ratio varied according to the reason for consultation, with cancer suspicion (52.9% 42.9; 62.8]) and
pediatric reasons (38.0% 30.0; 46.6]) showing the lowest CCM percentages. CCM percentages also varied significantly based on the setting where it was performed, ranging from 61.1% (private clinic) to 86.8% (endourology and general hospital). We show that two-thirds
of all urological outpatient cases could be completely managed by telemedicine outside of the pandemic. |
|
|
Utro, Filippo, Levovitz, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Authors present a common methodological framework to infer the phylogenomics from genomic data, be it reads of SARS-CoV-2
of multiple COVID-19 patients or bulk DNAseq of the tumor of a cancer patient. They uncovered new potential parallel mutation in the evolution of the SARS-CoV-2 virus. |
|
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COVID-19: Mathematical estimation of delay to deaths in relation to upsurges
in positive rates |
Victor, G, Hagen, et al |
Early human development |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study was carried out in order to devise an approach that may help to predict deaths based on upsurges (spikes
or waves) of cases. Publically available data for daily new cases and deaths from December 2019 to August 2020 was obtained from the Our World In Data website. For the purposes of more detailed analysis, in addition to total global data, three countries were
chosen for sub analysis: Italy, Germany and the United States. Delay to death (days) were as follows: World: 20.6 (95% CI: 8.4–32.8); USA: 19.8 (95% CI: 9.3–30.4); Germany: 18.8 (95% CI: 6.1–31.6); Italy: 2.4 (95% CI −10.2–15.0). |
|
Vilar Fernández, JA, Casal, et al |
Boletin de Estadistica e Investigacion Operativa |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
As part of the “Mathematics against coronavirus” initiative promoted by the Spanish Committee for Mathematics (CEMat),
an interactive web application based on R was developed to monitor and predict the short-term behavior of relevant variables in Covid-19 spreading. For every Spanish administrative region, predictions from a variety of models and techniques provided by independent
research groups were combined to generate cooperative predictions, which have been daily available on the web together with the official data from the Institute of Health Carlos III (ISCIII). Since forecast combination can improve forecasting accuracy, particularly
in contexts with high uncertainty, the goal was to use the forecasts of the Spanish mathematical community to obtain more accurate and stable predictions and, eventually, report conclusions to the authorities. This article provides a general overview of the
development and results of this project, motivating the use of combined forecasts and including information on the main stages of the process. © 2020 SEIO |
|
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Clinical effect of Guanggu Jisheng decoction in treatment of recovery stage
coronavirus disease 2019 |
Wan, XY, Meng, et al |
Academic Journal of Second Military Medical University |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Objective To observe the clinical effect of Guanggu Jisheng decoction on the treatment of coronavirus disease 2019
(COVID-19) during recovery stage. Methods A total of 122 convalescent COVID-19 patients in Guanggu Branch of Maternity and Child Healthcare Hospital of Hubei Province were treated with Guanggu Jisheng decoction for 3 consecutive courses, each course lasting
3 days. The changes of traditional Chinese medicine (TCM) syndromes before and after treatment were compared. Results According to the TCM syndrome scores, after one course of treatment (3 days), the total effective rate was 75.41%, with the effective rate
being 31.97%, the significant efficiency being 21.31%, and the clinical recovery rate being 22.13%. After two courses of treatment (6 days), the total effective rate was 86.89%, with the effective rate being 32.79%, the significant efficiency being 28.69%,
and the clinical recovery rate being 25.41%. After three courses of treatment (9 days), the total effective rate was 88.52%, with the effective rate being 16.39%, the significant efficiency being 31.15%, and the clinical recovery rate being 40.98%. The symptoms
of cough, fatigue, shortness of breath and sweating were significantly improved. |
|
Wang, Cuiyan, Chudzicka‐Czupała, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
From February to June 2020, we conducted an online Global Mental Health survey which recruited participants via a respondent-driven
sampling country in 8 countries (China, Pakistan, Philippines, Iran, Poland, Spain, USA and Vietnam). The online survey collected information on demographic characteristics, physical symptoms and health service utilisation, contact history, knowledge and concerns
regarding COVID-19, precautionary measures taken and additional health information variables among the countries involved. There were 5555 participants involved in the study, 31.4% male and 68.6% female, with an age range of 12-to above 50 years of age. China
had the highest IES-R score (mean=32.98, SD=15.42). Poland and Pakistan were found to be the two countries with the highest levels of anxiety, depression and stress; conversely, Vietnam had the lowest scores in stress (mean = 3.80, SD = 5.81), anxiety (mean
= 2.10, SD = 4.91) and depression (mean = 2.28, SD = 5.43). Female gender, age older than 50 years, crowded home environment, unemployment and student status were significant associated with adverse mental health (p<0.05). Our findings have identified protective
and risk factors associated with mental health that can help us to develop targeted psychological interventions for those who are more vulnerable during this pandemic. |
|
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PMC7417288; An air distribution optimization of hospital wards for minimizing
cross-infection |
Wang, JX, Cao, et al |
J Clean Prod |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
This paper reports on the air distribution optimization of a general three-bed hospital ward in China. Using the Eulerian-Lagrangian
method, sneeze process from patients who are assumed to be the virus carrier, which is responsible for a common event to trigger cross-infection, is simulated. The trajectory of the released toxic particle and the probability of approaching others in the same
ward are calculated. Two evaluation parameter, total maximum time (TMT) and overall particle concentration (OPC) to reflect the particle mobility and probability to cause cross-infection respectively, are developed to evaluate the proposed ten air distributions.
A relatively optimized air distribution proposal with the lowest TMT and OPC is distinguished through a three-stage analysis. Results show that a bottom-in and top-out air distribution proposal is recommended to minimize cross-infections. |
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Quantum Simulations of SARS-CoV-2 Main Protease Mpro Enable Accurate Scoring of Diverse Ligands |
Wang, Yuhang, Murlidaran, et al |
arXiv |
Coronavirology| Coronavirologie |
This article describes full density functional quantum mechanical (DFT/QM) simulations of Mpro in complex with various
ligands to obtain absolute ligand binding energies. Our calculations are enabled by a new cloud-native parallel DFT/QM implementation running on computational resources from Amazon Web Services (AWS). The results we obtain are promising: the approach is quite
capable of scoring a very diverse set of existing drug compounds for their affinities to Mpro and suggest the DFT/QM approach is potentially more broadly applicable to repurpose screening against this target. In addition, each DFT/QM simulation required only
~1 hour (wall clock time) per ligand. The fast turnaround time raises the practical possibility of a broad application of large-scale quantum mechanics in the drug discovery pipeline at stages where ligand diversity is essential. |
|
Wismüller, Axel, Stockmaster, et al |
arXiv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
To quantitatively investigate the clinical applicability of the tru-AI approach in radiology, we analyzed service requests
for automatically identifying intracranial hemorrhage (ICH) on head CT using a commercial AI solution. We analyzed data of N=9,421 emergency-setting non-contrast head CT studies at a major US healthcare system acquired from November 1, 2019 through June 2,
2020, and compared two observation periods, namely (i) a pre-pandemic epoch from November 1, 2019 through February 29, 2020, and (ii) a period during the COVID-19 pandemic outbreak, April 1-30, 2020. Although daily CT scan counts were significantly lower during
(40.1 +/- 7.9) than before (44.4 +/- 7.6) the COVID-19 outbreak, we found that ICH was more likely to be observed by AI during than before the COVID-19 outbreak (p<0.05), with approximately one daily ICH+ case more than statistically expected. Our results
suggest that, by tracking both large-scale utilization and AI results data in radiology, the tru-AI approach can contribute clinical value as a versatile exploratory tool, aiming at a better understanding of pandemic-related effects on healthcare. |
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|
Wyche, KP, Nichols, et al |
Science of the Total Environment |
Public health interventions*| Interventions de santé publique |
This study employed an ensemble of measurement and modelling techniques to investigate changes in air quality, atmospheric
composition and boundary layer reactivity in the South East of the UK post-lockdown. Findings showed that de-trended NO2 concentrations decreased by an average of 14–38% when compared to the mean of the same period over the preceding 5-years. We found that
de-trended particulate matter concentrations had been influenced by interregional pollution episodes, and de-trended ozone concentrations had increased across most sites, by up to 15%, such that total Ox levels were roughly preserved. 0-D chemical box model
simulations showed the observed increases in ozone concentrations during lockdown under the hydrocarbon-limited ozone production regime, where total NOx decreased proportionally greater than total non-methane hydrocarbons, which led to an increase in total
hydroxyl, peroxy and organic peroxy radicals. |
|
|
Xue, J, Zheng, et al |
International immunopharmacology |
Clinical data| Données cliniques |
Clearance of COVID-19 from the human body has not been established. Our study collected the laboratory test results
from patients and analyzed the correlation between early changes in serum indices and the virus clearance by univariable and multivariable COX regression models, with an aim to explore the risk factors for prolonged viral clearance. The study included 61 patients
with COVID-19 treated at the Fifth Medical Center of PLA General Hospital in Beijing from 20 January 2020 to 20 February 2020. We set the total observation of the disease course to 20 days and the patients were divided into two groups (prolonged group, > 20d
vs. normal group, ≤ 20d). The 48 patients with COVID-19 included in this study, 13 remained positive for viral nucleic acid monitoring 20 days after onset. The median for virus clearance was 16 days (range, 6–35 days). The results showed that hypertension,
a lactate dehydrogenase level > 211.5 U/L, an interleukin 6 (IL-6) level > 12.5 pg/ml, and a NK lymphocyte percentage > 0.5% were associated with prolonged viral clearance. Therefore, we showed that a history of hypertension, an elevated IL-6 level, and an
elevated percentage of NK cells were risk factors for prolonged viral clearance. © 2020 |
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Visits of fever clinic during the epidemic of coronavirus disease 2019:
A preliminary analysis |
Xue, XC, Jiang, et al |
Academic Journal of Second Military Medical University |
Clinical data| Données cliniques |
This study observed the visits of fever clinic during the epidemic of coronavirus disease 2019 (COVID-19) and the epidemic
characteristics of COVID-19, so as to analyze the disease development trend. Among the 2193 patients visiting our hospital between Jan. 15, 2020 and Feb. 29, 2020, 97.08% had respiratory system infection, followed by digestive system infection and urinary
system infection. Eighty-one suspected cases and 10 confirmed cases of COVID-19 were identified. Among the suspected cases, there were 38 males (46.91%) and 43 females (53.09%). Among the confirmed cases, four were males and six were females. All the 10 confirmed
patients were ≥50 years old and eight cases were retirees. Of the suspected cases, 15 (18.52%) had lived in Hubei province and 52 (64.20%) had an epidemiological history. Of the confirmed cases, seven had lived in Hubei province and all had an epidemiological
histories. Chest CT showed COVID-19 characteristics in 13 cases (16.05%). Among the 10 confirmed patients, the main clinical manifestations were also fever (nine cases) and cough (eight cases). The blood routine showed normal white blood cells (10 cases),
normal lymphocytes (six cases) and decreased lymphocytes (four cases). Chest CT showed COVID-19 characteristics in seven cases. |
|
Yang, Liwei, Chen, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study investigated the likely date of the emergence of the first COVID-19 case in Wuhan, China. Methods We constructed
a geographical-structured model, including 9122 county-level geographical units in 250 different regions or countries, and 26,094,036 flight plans. Using the model, we estimated the date of the number of deaths and the date of first death caused by COVID-19
in 155 different countries. We set a certain trigger for country and county level lockdown, and a built-in flight randomizer, to assess the different evidence that can suggest the possibility of different dates to be the emergence of the first COVID-19 case.
We found that our simulation results can only include the actual number of global deaths caused by COVID-19 on May 1,2020 inside the 95%PI when the date of the emergence of the first case is between September 15, 2019 and October 15, 2020; The lowest deviation
can be observed on September 22. We also found a decrease of R2 when we deploy later emergence of the first case; unexpectedly, an abnormal increase of R2 on September 22 is observed. When focusing on the eight major epicenters, we found that the number of
deaths in these eight countries can only be all included inside the 95%PI when the emergence is on September 15 and September 22. The deviation of the first deaths demonstrates different patterns depending on the continent, whereas the global average demonstrates
a pattern of normal distribution with a maximum of 0.2107 on September 22 after the removal of outliers. This could suggest a high likelihood of the emergence of the first case of COVID-19 be around September 15, 2020 and September 22, 2020. |
|
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Inhibition of SARS-CoV-2 viral entry in vitro upon
blocking N- and O-glycan elaboration |
Yang, Qi, Hughes, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We expressed different glycoforms of the Spike-protein and ACE2 in CRISPR-Cas9 glycoengineered cells, and developed
corresponding SARS-CoV-2 pseudovirus. |
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Modelling COVID-19 transmission in supermarkets using an agent-based model |
Ying, Fabian, O'Clery, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission
Public health interventions*| Interventions de santé publique |
We formulate an agent-based model of customer movement in a supermarket with a simple virus transmission model based
on the amount of time a customer spends in close proximity to infectious customers. We apply our model to synthetic store and shopping data to show how one can use our model to estimate the number of infections due to human-to-human contact in stores and how
to model different store interventions. In our synthetic store, a directed store layout does not help in reducing the exposure time, as it increases the customer shopping time, so more customers are in the store at any given time. |
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Glycyrrhizic acid exerts inhibitory activity against the spike protein of SARS-CoV-2 |
Yu, S, Zhu, et al |
Phytomedicine |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study, a combination of computer-aided drug design and biological verification was used to discover active
monomers from traditional Chinese medicine. glycyrrhizic acid (ZZY-44) was found to be the most efficient and nontoxic broad-spectrum anti-coronavirus molecule in vitro, especially, the significant effect on SARS-CoV-2, which provided a theoretical basis for
the study of the pharmacodynamic material basis of traditional Chinese medicine against SARS-CoV-2 . |
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Cardiac troponin I in SARS-CoV-2-patients: The additional prognostic value of serial
monitoring |
Zaninotto, M, Mion, et al |
Clinica Chimica Acta |
Clinical data| Données cliniques |
This study aimed to investigate whether serial measurements of high sensitivity troponin I (hs-cTnI) might provide
additional information in SARS-CoV-2 patients's clinical management. In 69 out of 113 patients hs-cTnI has been measured, showing in 31 (45%) values higher than 99th percentiles in at least one occasion. In 50 patients (72%) a kinetic evaluation (at least
2 measurements during 24 h) has been carried out. Patients were subdivided into five groups: 1 (n = 44) and 2 (n = 19) no measurement of hs-cTnI or no monitoring respectively; 3 (n = 15) no significant variations during monitoring; 4 (n = 8) and 5 (n = 27)
significant variations with values persistently below or sometimes higher than 99th percentiles, respectively. Group 5 patients had a longer hospital stay (median 37 days, p = 0.0001), a more aggressive disease (6 out of 27, 22%, died), more often need admission
to ICU (n = 25, 92.6%, p < 0.0001), and show one or more peak values, sometime preceded by severe hypoxia. |
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The impacts of the COVID-19 lockdown on air quality in the guanzhong basin, China |
Zhang, K, Leeuw, et al |
Remote Sensing |
Public health interventions*| Interventions de santé publique |
We report on a study on the changes in air quality in the Guanzhong Basin during the COVID-19 lockdown period. We compared
the concentrations of PM2.5, PM10, SO2, NO2, CO and O3 obtained from ground-based monitoring stations before and after the COVID-19 outbreak. The analysis confirmed that the air quality in the Guanzhong Basin was significantly improved after the COVID-19 outbreak. |
|
Zhang, Xupin, Lyu, et al |
arXiv |
Public Health response| Interventions de santé publique |
To investigate the hoarding behaviors in response to the COVID-19 pandemic, we propose a novel computational framework
using large scale social media data. First, we collect hoarding-related tweets shortly after the outbreak of the coronavirus. Next, we analyze the hoarding and anti-hoarding patterns of over 42,000 Twitter users in the United States from February 1 to April
30 and dissect the hoarding-related tweets by age, gender, and geographic location. With the proposed computational framework, we derive significant findings, e.g. the percentage of females in both hoarding and anti-hoarding groups is higher than that of the
general Twitter users. Furthermore, using topic modeling, we investigate the opinions expressed about the hoarding behavior by categorizing these topics according to demographic and geographic groups. We also calculate the anxiety scores for the hoarding and
anti-hoarding related tweets using a lexical approach. By comparing their anxiety scores with the typical Twitter anxiety score, we reveal further insights. The LIWC anxiety mean for the hoarding related tweets is significantly higher than the general Twitter
anxiety mean. Interestingly, beer has the highest calculated anxiety score compared to other hoarded items mentioned in the tweets. |
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Evidence-based framework and implementation of China’s strategy in combating COVID-19 |
Zhao, D, Lin, et al |
Risk Management and Healthcare Policy |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This article aims to use empirical data from all cases from a prefecture-level city of China to introduce and examine
the feasibility and efficiency of the screening and isolation strategies and how these were essential in combatting the COVID-19 outbreak. Of the city’s total population, 24% were screened for COVID-19 and isolated at home or designated locations for two weeks.
From these, a total of 146 confirmed cases of COVID-19 were analysed. Of all cases, 51% were traced from Wuhan, and 21% of patients were in close contact with confirmed cases from outside of the city. Initially, 13% of all patients reported having no clear
symptoms, while 42% of patients presented with fever and/ or other symptoms. Compared with local patients, new arrivals to the city had fewer days between their exposure and the development of symptoms of COVID-19 (P<0.001), and fewer days from the time they
developed symptoms to the confirmation of COVID-19 (P<0.001), respectively. |
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The Strand-biased Transcription of SARS-CoV-2 and Unbalanced
Inhibition by Remdesivir |
Zhao, Yan, Sun, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We deeply sequenced both strands of RNA and found SARS-CoV-2 transcription is strongly biased to form the sense strand.
During negative strand synthesis, apart from canonical sub-genomic ORFs, numerous non-canonical fusion transcripts are formed, driven by 3-15 nt sequence homology scattered along the genome but more prone to be inhibited by SARS-CoV-2 RNA polymerase inhibitor
Remdesivir. The drug also represses more of the negative than the positive strand synthesis as supported by a mathematic simulation model and experimental quantifications. Overall, this study opens new sights into SARS-CoV-2 biogenesis and may facilitate the
anti-viral drug design. |
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Aspergillus But Not Candida: Fatal Fungus Infection in COVID-19
Critical Patients |
Zhong, Aifang, Yang, et al |
SSRN- Lancet prepublication |
Clinical data| Données cliniques |
This single center retrospective study screened for bacteria and fungi infection after COVID-19 being confirmed. Enrolled
236 patients with COVID-19 to analyze the clinical characteristics, fungal strains, mortality, and laboratory data of different groups. The result revealed that 5 mortality in positive group were all related to aspergillus infection while candida infection
rarely caused death. Aspergillus was most common in non-survivors while candida was most common in survivors. In terms of interleukin-6 (IL6), viral loads, nucleic acid clearance time, etc, fungal serologically positive group had a higher level than negative
group. |
|
Zhou, J, Liao, et al |
Clinical imaging |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
CT has an important significance for diagnosis of COVID-19 which has become the focus of global attention. This manuscript
summarizes the differential points of CT findings between COVID-19 and S. pneumoniae pneumonia, which is significant for disease treatment and patient recovery. Improving radiologists' ability to diagnose COVID-19 is conducive to controlling the development
of the COVID-19. |
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|
Zuccon, W, Comassi, et al |
American Journal of Emergency Medicine |
Clinical data| Données cliniques |
In this work, the survival and mortality data of 54 consecutive patients admitted to the Intensive Care Unit (ICU)
and suffering from severe respiratory insufficiency imputable to viral SARS - CoV - 2 infection were analyzed and shared, after a critical review of the evidence in order to optimize the most dedicated clinical and treatment strategy, for a future ‘targeted’
management in the care of the possible return flu outbreak. |
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Mitigation strategies to fight the COVID-19 pandemic—present, future and beyond |
Abideen, AZ, Mohamad, et al |
Journal of Health Research |
Review Literature| Revue de littérature |
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Non-respiratory presentations of COVID-19, a clinical review |
AlSamman, M, Caggiula, et al |
American Journal of Emergency Medicine |
Review Literature| Revue de littérature |
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Avila, J, Long, et al |
American Journal of Emergency Medicine |
Review Literature| Revue de littérature |
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Baird, BJ, Sung, et al |
Otolaryngologic clinics of North America |
Review Literature| Revue de littérature |
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Bansal, A, Singh, et al |
Heart and Lung |
Review Literature| Revue de littérature |
SR-MA: conducted a systematic review and meta-analysis of the published literature in PubMed, Embase and Cochrane
databases through April 9, 2020. We conclude that SARS-CoV-2 infected patients with elevated D-dimers have worse clinical outcomes (all-cause mortality, ICU admission or ARDS) and thus measurement of D-dimers can guide in clinical decision making.
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Insights
into the COVID-19 pandemic: Origin, pathogenesis, diagnosis, and therapeutic interventions |
Berekaa, MM |
Front Biosci (Elite Ed) |
Review Literature| Revue de littérature |
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Bhandari, TR, Dangal, et al |
Kathmandu University Medical Journal |
Review Literature| Revue de littérature |
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Bhuriwala, Zainab, Ladak, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
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Button, K, Frye, et al |
Research in Transportation Economics |
Review Literature| Revue de littérature |
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Smoking and covid-19: Renin-angiotensin system the hidden link |
Chaudhary, AP, Adna Nelson, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Cancer is associated with coronavirus disease (COVID-19) severity and mortality:
A pooled analysis |
Cheruiyot, I, Kipkorir, et al |
American Journal of Emergency Medicine |
Review Literature| Revue de littérature |
SR-MA: search of literature was conducted between November 1, 2019, to May 26th, 2020 on PubMed and China National
Knowledge Infrastructure (CNKI). Malignancies were significantly associated with a 2-fold increase in the odds of developing severe COVID-19 disease, as well as mortality. |
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da Silva, FCT, Neto, et al |
Prog Neuropsychopharmacol Biol Psychiatry |
Review Literature| Revue de littérature |
SR-MA: review was conducted based on papers that were published at MEDLINE, BMJ, PsycINFO, and LILACS. Health professionals,
regardless of their age, showed significant levels of mental disorders. We observed a prevalence of anxiety and depression. Insomnia was a risk factor for both. |
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Davis, ME, Yan, et al |
Otolaryngologic clinics of North America |
Review Literature| Revue de littérature |
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Tissue proteases and immune responses: Influencing factors of covid-19 severity and
mortality |
de Oliveira, NMT, Figueiredo, et al |
Pathogens |
Review Literature| Revue de littérature |
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Gorini, F, Chatzianagnostou, et al |
International Journal of Environmental Research and Public Health |
Review Literature| Revue de littérature |
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Holidays over: A review of actual COVID-19 school outbreaks up to September
2020 |
Grech, V, Grech, et al |
Early human development |
Review Literature| Revue de littérature |
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Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19 |
Husain, A, Byrareddy, et al |
Chemico-biological interactions |
Review Literature| Revue de littérature |
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Iranzadasl, M, Karimi, et al |
Integr Med Res |
Review Literature| Revue de littérature |
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Iturbe-Hernandez, T, de Guadiana Romualdo, et al |
Drugs in Context |
Review Literature| Revue de littérature |
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Jena, A, Singh, et al |
Digestive and Liver Disease |
Review Literature| Revue de littérature |
SR: searched the databases using PubMed and Embase on 6 August 2020. Although our analysis is limited by lack of studies
from Africa and South Asia, it demonstrates that adherence to therapies will remain a concern with the surge in COVID-19 in newer regions and with second surges. |
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PMC7386206; Evidence for the medicinal value of Squama Manitis (pangolin scale):
A systematic review |
Jin, X, Chua, et al |
Integr Med Res |
Review Literature| Revue de littérature |
SR: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure Database (CNKI), WanFang Database and
SinoMed were searched from inception to May 1, 2020. There is no reliable evidence that Squama Manitis has special medicinal value. The removal of Squama Manitis from Pharmacopoeia is rational. |
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Krishnan, N, Devadasan, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Liu, M, Gao, et al |
Integr Med Res |
Review Literature| Revue de littérature |
SR-MA: literature search using six electronic databases from December 1, 2019, to June 2, 2020. LH combined with
conventional treatment seems to be more effective for patients with mild or ordinary COVID-19. |
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Loss of smell in covid-19 patients: A critical review with emphasis on the use of
olfactory tests |
Marchese-Ragona, R, Restivo, et al |
Acta Otorhinolaryngologica Italica |
Review Literature| Revue de littérature |
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Márquez-González, H, Miranda-Novales, et al |
Boletin medico del Hospital Infantil de Mexico |
Review Literature| Revue de littérature |
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Renin-angiotensin system and coronavirus disease 2019: A narrative review |
Mascolo, A, Scavone, et al |
Frontiers in Cardiovascular Medicine |
Review Literature| Revue de littérature |
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Panday, DR, Panday, et al |
Kathmandu University Medical Journal |
Review Literature| Revue de littérature |
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COVID-19 cardiac arrest management: A review for emergency clinicians |
Ramzy, M, Montrief, et al |
American Journal of Emergency Medicine |
Review Literature| Revue de littérature |
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Involvement of the nervous system in COVID-19: The bell should toll in the brain |
Satarker, S, Nampoothiri, et al |
Life Sciences |
Review Literature| Revue de littérature |
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Shibabaw, T |
Journal of Inflammation Research |
Review Literature| Revue de littérature |
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Host receptors of influenza viruses and coronaviruses—molecular mechanisms of recognition |
Sriwilaijaroen, N, Suzuki, et al |
Vaccines |
Review Literature| Revue de littérature |
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Supriadi, O, Musthan, et al |
Systematic Reviews in Pharmacy |
Review Literature| Revue de littérature |
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Teimury, A, Khaledi, et al |
Risk Management and Healthcare Policy |
Review Literature| Revue de littérature |
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COVID-19 and coronary heart disease – strategies in interventional cardiology |
Trbušić, M, Bulj, et al |
Medicus |
Review Literature| Revue de littérature |
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Cytokine storm and immunoregulatory therapy of coronavirus pneumonia |
Wang, T, Jiang, et al |
Academic Journal of Second Military Medical University |
Review Literature| Revue de littérature |
|
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Valinomycin as a potential antiviral agent against coronaviruses: A review |
Zhang, D, Ma, et al |
Biomedical Journal |
Review Literature| Revue de littérature |
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Democracy in a global emergency five lessons from the covid-19 pandemic |
Afsahi, A, Beausoleil, et al |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
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Aith, F, Martínez, et al |
Revista Panamericana de Salud Publica/Pan American Journal of Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Annaelise, M, Sónia, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
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Changes in the field of pharmacy
during the COVID-19 pandemic |
Arbanas, D |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Encouraging physical activity during and after pregnancy in the COVID-19 era, and beyond |
Atkinson, L, De Vivo, et al |
International Journal of Environmental Research and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Infrastructural Europe: Eu law and human life in times of the covid-19 pandemic |
Azoulai, L |
Revista de Derecho Comunitario Europeo |
Commentary/Editorial| Commentaire/Éditorial |
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Barrientos-Avendaño, E, Areniz-Arevalo, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
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Monitoring and treatment of renal transplant patients during
the COVID-19 pandemic |
Bašić-Jukić, N, Jurić, et al |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Bhagat, RK, Davies Wykes, et al |
Journal of Fluid Mechanics |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in children: what did we learn from the first wave? |
Bogiatzopoulou, A, Mayberry, et al |
Paediatrics and Child Health (United Kingdom) |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of the COVID-19 pandemic on patients with anxiety
and depressive disorders |
Brečić, P, Jendričko, et al |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Brzezicki, MA, Crockett, et al |
Journal of Surgical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Budd, L, Ison, et al |
Research in Transportation Business and Management |
Commentary/Editorial| Commentaire/Éditorial |
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Bulum, T |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Public media
in ecuador: When democracy in not enough for everyone |
Carrión, GS, Larrea, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
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COVID and the era of emergencies what type of freedom is at stake? |
Celermajer, D, Nassar, et al |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
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Lessons from COVID-19: How human behaviour may influence the science |
Ceriello, A |
Diabetes research and clinical practice |
Commentary/Editorial| Commentaire/Éditorial |
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Otolaryngology During the COVID-19 Pandemic: What We Have Learned in Year One |
Chandrasekhar, SS |
Otolaryngologic clinics of North America |
Commentary/Editorial| Commentaire/Éditorial |
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Choi, SY |
Finance Research Letters |
Commentary/Editorial| Commentaire/Éditorial |
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Onkologie
in Zeiten von COVID-19: Interdisziplinarität und Interprofessionalität wichtiger denn je |
Christ, MM |
Arzneimitteltherapie |
Commentary/Editorial| Commentaire/Éditorial |
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Christiaensen, L, Rutledge, et al |
Food Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Cosyns, B, Motoc, et al |
JACC: Cardiovascular Imaging |
Commentary/Editorial| Commentaire/Éditorial |
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Couto, M |
Revista Portuguesa de Imunoalergologia |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 is ageist, sexist, ruthless, dispassionate and opportunistic – Protecting
our vulnerable |
Cuschieri, S, Grech, et al |
Early human development |
Commentary/Editorial| Commentaire/Éditorial |
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Darabi, P, Kalo, et al |
Journal of Cellular and Molecular Anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Davies, L |
Practising Midwife |
Commentary/Editorial| Commentaire/Éditorial |
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Sars-cov-2: Previous coronaviruses, immune response, and development of vaccines |
De León-Rodríguez, SG, Hernández-Rico, et al |
Boletin medico del Hospital Infantil de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Dickins, TE, Schalz, et al |
Learning and motivation |
Commentary/Editorial| Commentaire/Éditorial |
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Diener, HC |
Arzneimitteltherapie |
Commentary/Editorial| Commentaire/Éditorial |
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Do-Nguyen, C, Hong, et al |
Journal of Thoracic and Cardiovascular Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations for reopening elective surgery services during the SARS-CoV-2 pandemic |
Duarte, FOM, Bedoya, et al |
Revista Panamericana de Salud Publica/Pan American Journal of Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7324031; Potential Impact of Delay in Cancer Screening due to COVID-19 |
Ehrlich, MI, Saif, et al |
Cancer Med J |
Commentary/Editorial| Commentaire/Éditorial |
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Vehicular Networks for Combating a Worldwide Pandemic: Preventing the Spread of COVID-19 |
Elbir, AhmetM, Gurbilek, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Mental health of surgeons during the COVID-19 pandemic: An urgent need for intervention |
Elhadi, M, Msherghi, et al |
Surgery (United States) |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2, A new causative agent of Guillain-Barré syndrome? |
Esteban Molina, A, Mata Martínez, et al |
Medicina Intensiva |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19-Associated Thromboembolic Events Causing Acute Mesenteric Ischaemia |
Fan, BE |
Academic Radiology |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19: From grief and mourning to prolonged grief disorder |
Farinha-Silva, S, Reis-Pina, et al |
Acta Medica Portuguesa |
Commentary/Editorial| Commentaire/Éditorial |
|
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Management of rheumatic diseases during the COVID-19 pandemic: Beyond telehealth services |
Fernandes, AL, Silva, et al |
Acta Medica Portuguesa |
Commentary/Editorial| Commentaire/Éditorial |
|
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Interim Guidance for Urodynamic Practice during COVID-19 Pandemic |
Figueiredo, AA, Fernandes, et al |
Int Braz J Urol |
Commentary/Editorial| Commentaire/Éditorial |
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Flockemann, M |
Cambridge Journal of Postcolonial Literary Inquiry |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7324032; Consequences of the COVID-19 Pandemic on Cancer Clinical Trials |
Flores, S, Kurian, et al |
Cancer Med J |
Commentary/Editorial| Commentaire/Éditorial |
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Freeman, J |
Family medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Funk, DC, Moss, et al |
Journal of pain and symptom management |
Commentary/Editorial| Commentaire/Éditorial |
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Operations
research helps public health services managers planning resources in the COVID-19 crisis |
García-Vicuña, D, Cildoz, et al |
Boletin de Estadistica e Investigacion Operativa |
Commentary/Editorial| Commentaire/Éditorial |
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Centralized or decentralized which governance systems are having a 'good' pandemic? |
Gaskell, J, Stoker, et al |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
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Gilbert, R |
Practising Midwife |
Commentary/Editorial| Commentaire/Éditorial |
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Godwin, B |
Practising Midwife |
Commentary/Editorial| Commentaire/Éditorial |
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Groner, MF, de Carvalho, et al |
Int Braz J Urol |
Commentary/Editorial| Commentaire/Éditorial |
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Guasti, P |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
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Guérot, U, Hunklinger, et al |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
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Transmedia
convergence and agenda setting: Covid-19 health emergency analysis in ecuador |
Gutiérrez, FC, Luque, et al |
RISTI - Revista Iberica de Sistemas e Tecnologias de Informacao |
Commentary/Editorial| Commentaire/Éditorial |
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Han, E, Tan, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Harkness, M |
Practising Midwife |
Commentary/Editorial| Commentaire/Éditorial |
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New York's COVID-19 shelter-in-place and acute appendicitis in children |
Hassoun, A, Kadenhe-Chiweshe, et al |
Journal of pediatric surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Henriquez-Marquez, K, Zambrano, et al |
Atencion Primaria |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations for the care of patients with bipolar disorder during the COVID-19
pandemic |
Hernández-Gómez, A, Andrade-González, et al |
Journal of affective disorders |
Commentary/Editorial| Commentaire/Éditorial |
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Herrero, MTV, de la Torre, et al |
Revista de la Asociacion Espanola de Especialistas en Medicina del Trabajo |
Commentary/Editorial| Commentaire/Éditorial |
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Hoang, BX, Han, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Shift to digital perspectives on Hilton (2016) from the perspective of practice |
Hodges, CB |
Educational Technology Research and Development |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 impact on colleagues in the powder diffraction community |
Hubbard, C |
Powder Diffraction |
Commentary/Editorial| Commentaire/Éditorial |
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Ibrahimagić, OĆ, Kunić, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Ireland, J |
Practising Midwife |
Commentary/Editorial| Commentaire/Éditorial |
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Isakova-Sivak, Irina, Rudenko, et al |
The Lancet Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Izadi-Mazidi, M, Riahi, et al |
Journal of Loss and Trauma |
Commentary/Editorial| Commentaire/Éditorial |
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Reducing alcohol misuse during the COVID-19 pandemic in Kenya |
Jaguga, Florence, Kiburi, et al |
The Lancet Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Phytotherapeutic evidence against coronaviruses and prospects for COVID-19 |
Jamiu, AT, Aruwa, et al |
Pharmacognosy Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Jarabo, JR, Martínez, et al |
Cirugia Espanola |
Commentary/Editorial| Commentaire/Éditorial |
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Johnson, J, Melvin, et al |
American Journal of Perinatology |
Commentary/Editorial| Commentaire/Éditorial |
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Kadyrova, A, Kulbaeva, et al |
Visual Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Measures of mortality in coronavirus (COVID-19) compared with SARS and MERS |
Kalteh, EA, Sofizadeh, et al |
Journal of Cellular and Molecular Anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Developing health policies in patients presenting with SARS-CoV-2: consider
tuberculosis |
Keddy, KarenH, Migliori, et al |
The Lancet Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Mental health, mental capacity, ethics, and the law in the context of COVID-19
(coronavirus) |
Kelly, BD, Drogin, et al |
International journal of law and psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Khurana, S, Haleem, et al |
J Clean Prod |
Commentary/Editorial| Commentaire/Éditorial |
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Home schooling, remote teaching and digital Bildung in societal crisis |
Krumsvik, RJ |
Nordic Journal of Digital Literacy |
Commentary/Editorial| Commentaire/Éditorial |
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Kutleša, M |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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After the storm has passed: Translating crisis experience into useful knowledge |
Lee, GK, Lampel, et al |
Organization Science |
Commentary/Editorial| Commentaire/Éditorial |
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Lee, SC, Stojmenova, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Leng, C, Challoner, et al |
Journal of Plastic, Reconstructive and Aesthetic Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Kein
höheres Risiko von COVID-19 durch systemische Therapie bei Psoriasis |
Lenzen-Schulte, M |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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A clash of epidemics: Impact of the COVID-19 pandemic response on opioid overdose |
Linas, BP, Savinkina, et al |
Journal of substance abuse treatment |
Commentary/Editorial| Commentaire/Éditorial |
|
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Interpretation of leisure sports in the pandemic situation of COVID 19 |
Ling, P |
World Leisure Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Homocysteine and the SARS-CoV-2 Coronavirus – The X Factor of
Severe Disease and Death |
Lord, Nancy, Ruwart, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
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Lovrenčić-Huzjan, A |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Low, PH, Mangat, et al |
World Neurosurgery |
Commentary/Editorial| Commentaire/Éditorial |
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Lymperopoulos, NS, Dunne, et al |
Journal of Plastic, Reconstructive and Aesthetic Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Macdonald, Catherine, Soll, et al |
bioRxiv |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in Italy: did the virus run on an ancient Roman road? |
Maietti, E, Golinelli, et al |
Journal of Public Health (Germany) |
Commentary/Editorial| Commentaire/Éditorial |
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Manzanares, W, Moreira, et al |
Nutrition |
Commentary/Editorial| Commentaire/Éditorial |
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Merkel, W |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and agitated patients with dementia in family
medicine clinics |
Mihaljević-Peleš, A |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of COVID-19 on professional and personal responsibilities of Massachusetts
physicians |
Miller, KA, Mannix, et al |
American Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Mohamed, K, Rezaei, et al |
American Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Telephonic psychotherapy in India: A reminder of challenges in times of COVID-19 |
Mondal, I, Anand, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Morales, D, Lombardía, et al |
Boletin de Estadistica e Investigacion Operativa |
Commentary/Editorial| Commentaire/Éditorial |
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Drawing lessons from the pandemic for a new pharmacy practice |
Mrozovski, JM |
Actualites Pharmaceutiques |
Commentary/Editorial| Commentaire/Éditorial |
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Muñoz-Hernández, O, Solórzano-Santos, et al |
Boletin medico del Hospital Infantil de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Nakić, V |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Pharmacy students in between pedagogical continuity and field mobilization |
Napieralski, J |
Actualites Pharmaceutiques |
Commentary/Editorial| Commentaire/Éditorial |
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Novaes Rocha, V |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Characterising neuropsychiatric disorders in patients with COVID-19 |
Oldham, MarkA, Slooter, et al |
The Lancet Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Owen, D |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
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Change over time of COVID-19 hospital presentation in Northern Italy |
Patti, G, Mennuni, et al |
European journal of internal medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Pavliša, G, Ljubičić, et al |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Fungal co-infection in COVID-19 patients: Should we be concerned? |
Pemán, J, Ruiz-Gaitán, et al |
Revista Iberoamericana De Micologia |
Commentary/Editorial| Commentaire/Éditorial |
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Perchinunno, F, Stucci, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Peršec, J, Šribar, et al |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Piquero, AR, Riddell, et al |
American Journal of Criminal Justice |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19
pandemic: What is known till June 2020 and what is yet to know? |
Piryani, RM, Piryani, et al |
Kathmandu University Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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What
we know of the prognostic value of lymphopenia in sarscov-2 infection? |
Pourbagheri-Sigaroodi, A, Bashash, et al |
Iranian Journal of Blood and Cancer |
Commentary/Editorial| Commentaire/Éditorial |
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Prejac, J |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Protić, A |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Puškarić, F, Čikeš, et al |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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La
Estadística y la Investigación Operativa en la lucha contra la COVID-19 |
Ramos, AG, Abad, et al |
Boletin de Estadistica e Investigacion Operativa |
Commentary/Editorial| Commentaire/Éditorial |
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Rapeli, L, Saikkonen, et al |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
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Recker, F, Weber, et al |
Geburtshilfe und Frauenheilkunde |
Commentary/Editorial| Commentaire/Éditorial |
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Reingle Gonzalez, JM, Molsberry, et al |
American Journal of Criminal Justice |
Commentary/Editorial| Commentaire/Éditorial |
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Reljić, A |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Concerns about COVID-19 and tuberculosis in Brazil: Social and public health impacts |
Ribeiro, VST, Telles, et al |
Enfermedades infecciosas y microbiologia clinica |
Commentary/Editorial| Commentaire/Éditorial |
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Redeployment of junior maxillofacial surgery staff during COVID-19—the Gloucester
ITU experience |
Richards, JA, Walker, et al |
British Journal of Oral and Maxillofacial Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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The democracy of everyday life in disaster holding our lives in their hands |
Rosenblum, NL |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
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When is an editorial not an editorial? The COVID-19 (quarantine, Era I) edition |
Ruby Rich, B |
Film Quarterly |
Commentary/Editorial| Commentaire/Éditorial |
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Older adults should not be omitted from inclusion in clinical trials of SARS-CoV-2
vaccines |
Sacco, G, Célarier, et al |
Maturitas |
Commentary/Editorial| Commentaire/Éditorial |
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Sagawa, T, Inoue, et al |
Preventive medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Salto-Alejandre, S, Roca-Oporto, et al |
Journal of Infection |
Commentary/Editorial| Commentaire/Éditorial |
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Samardžić, J |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Santini, M, Kusulja, et al |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Semeraro, F, Gamberini, et al |
Resuscitation |
Commentary/Editorial| Commentaire/Éditorial |
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Seneviratne, O, Roth, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Serafim Vilela, AC, Costa, et al |
Journal of Oral and Maxillofacial Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Sharma, A, Borah, et al |
Journal of Business Research |
Commentary/Editorial| Commentaire/Éditorial |
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Smart City: A Perspective of Emergency and Resilience at a Community Level in
Shanghai |
Shi, X, Sun, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Shrivastava, SR, Shrivastava, et al |
African Health Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Sicard, J |
Actualites Pharmaceutiques |
Commentary/Editorial| Commentaire/Éditorial |
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Sobol, M, Blachnio, et al |
Social Science and Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Development of an information website on the proper use of medicines during the
pandemic |
Societe francaise de pharmacologie et de, therapeutique, Societe, et al |
Actualites Pharmaceutiques |
Commentary/Editorial| Commentaire/Éditorial |
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Soehardi, S, Untari, et al |
Systematic Reviews in Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
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Solórzano-Santos, F, Garduño-Espinoza, et al |
Boletin medico del Hospital Infantil de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Tan, LF, Tee, et al |
American Journal of Geriatric Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Tanmoy, TI, Hossain, et al |
Pharmacologyonline |
Commentary/Editorial| Commentaire/Éditorial |
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Dysimmunity and inflammatory storm: Watch out for bone lesions in COVID-19 infection |
Tao, H, Ge, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Tomašković, I |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 policies in the UK and consequences for mental health |
Townsend, Ellen |
The Lancet Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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The Lombardy region of Italy launches the first investigative COVID-19 commission |
Usuelli, Michele |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Characterising neuropsychiatric disorders in patients with COVID-19 – Authors'
reply |
Varatharaj, Aravinthan, Pollak, et al |
The Lancet Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Vázquez-Cornejo, E |
Boletin medico del Hospital Infantil de Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Psychological impact of the COVID-19 pandemic on health care professionals |
Vignaud, P, Prieto, et al |
Actualites Pharmaceutiques |
Commentary/Editorial| Commentaire/Éditorial |
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Vitón-Castillo, AA, Lazo Herrera, et al |
Educacion Medica |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and chronic obstructive pulmonary diseases (Asthma
and COPD) |
Vrbica, Ž |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Characterising neuropsychiatric disorders in patients with COVID-19 |
Wade, Dorothy, Howell, et al |
The Lancet Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Wambier, CG, Vaño-Galván, et al |
Journal of the American Academy of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
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Wang, GX, Chou, et al |
Academic Radiology |
Commentary/Editorial| Commentaire/Éditorial |
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The characterization of chronic rhinosinusitis in hospitalized patients with COVID-19 |
Wang, H, Song, et al |
Journal of Allergy and Clinical Immunology: In Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Latin america and covid-19 political rights and presidential leadership to the test |
Weiffen, B |
Democratic Theory |
Commentary/Editorial| Commentaire/Éditorial |
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Xia, Shengli, Zhang, et al |
The Lancet Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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A first-aid procedure for staff who fainted in coronavirus disease 2019
isolation ward |
Xiao, Y, Liu, et al |
Academic Journal of Second Military Medical University |
Commentary/Editorial| Commentaire/Éditorial |
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Žerjavić, NL |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Tocilizumab is recommended for the treatment of severe COVID-19 |
Zhou, Y, Wei, et al |
EBioMedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Zielinski, S, Botero, et al |
International Journal of Environmental Research and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Živković, NP, Margeta, et al |
Medicus |
Commentary/Editorial| Commentaire/Éditorial |
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Long COVID: let patients help define long-lasting COVID symptoms |
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Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Commentary/Editorial| Commentaire/Éditorial |
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22nd International
Conference on Human Computer Interaction, HCII 2020 |
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Commentary/Editorial| Commentaire/Éditorial |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives