Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-10-13
Good afternoon,
There are 717 citations in today’s scan. 357 were considered primary research or review literature.
Highlights today include:
CANADA
·
Isho et al.
confirmed that serum and saliva IgG antibodies to SARS-CoV-2 are maintained in the majority of COVID-19 patients for at least 3 months PSO. IgG responses in saliva may serve as a surrogate measure of systemic
immunity to SARS-CoV-2 based on their correlation with serum IgG responses.
PUBLIC HEALTH INTERVENTIONS
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Mukherjee et al.
built an epidemiological model to investigate the strategies necessary for educational institutions to reopen safely. The authors showed that increasing the testing levels from 0.2 per capita per day to 0.3 per capita can reduce the infectivity from
0.25 to 0.01. The authors cross-validate the results with data from many universities in the United States and showed that institutions with higher levels of testing are associated with lower infections. The authors estimate from data on 228 different universities
across the United States shows that an increase of infection rate at the county where a university is located by 1% has the potential to increase the institutional infection rate by an average of 0.14%.
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Simha and Rao
assess cough airflows, using the schlieren method that is a highly sensitive, non-intrusive flow visualization technique is used. It can directly image weak density gradients produced by coughs. An assessment of different methods of covering the mouth
while coughing is arrived at by using observations from high speed schlieren images. The effectiveness of coughing into the elbow is examined
TRANSMISSION
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Laws et al describes a cohort of children exposed to SARS-CoV-2 in the household and their resulting infection rates, transmission patterns, and symptom profiles. The study
enrolled individuals with COVID-19 and their household contacts, assessed daily symptoms prospectively for 14 days, and obtained specimens for SARS-CoV-2 RT-PCR and serology testing. Results find that secondary infection rates for adults (30%) and children
(28%) were similar. Among households with potential for transmission from children, child-to-adult transmission may have occurred in 2/10 (20%), and child-to-child transmission may have occurred in 1/6 (17%). Pediatric case-patients most commonly reported
headache (79%), sore throat (68%), and rhinorrhea (68%).
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Dhawan and Pandley provide evidence about vertical transmission in Covid-19 is sparse and rapidly evolving . Authors
report one case with probable intrapartum transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in a neonate with respiratory distress.
IPAC
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Amoah et al
reported on the SARS-CoV-2 contamination on key contact surfaces in shared toilets, in the city of Durban, using droplet digital PCR and assessed the probabilistic risks of COVID-19 infections. Approximately, 53-69% of the contact surfaces were contaminated,
with SARS-CoV-2 viral loads per cm2 ranging from 25.9 to 132.69 gc/cm2. Toilet seats had the highest contamination per cm2. The probabilistic assessment showed a high potential for COVID-19 infections. Touching the internal latch of the toilet cubicle had
the highest risk of infections when a person uses the toilet once in a day, increasing to 1.0x10-1(1.4x10-3) for three uses in a day. Observed a significant reduction in viral loads on the contaminated surfaces after cleaning.
EPIDEMIOLOGY
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Seclén et al
report data from Peru which suggests that physiological adaptation in a hypoxic environment at high altitude may protect persons from the severe impact of acute infection caused by SARS-CoV-2.
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Maltezou et al.
Studied 203 SARS-CoV-2-infected children; 111 (54.7%) had an asymptomatic infection. Among the 92 children (45.3%) with
COVID-19, 24 (26.1%) were hospitalized. Infants <1 year were more likely to develop COVID-19. There was no significant difference between viral load and age, sex,
underlying condition, fever and hospitalization, as well as between type of SARS-CoV-2 infection and age, sex, underlying condition and viral load. Transmission from a household member accounted
for 132 of 178 (74.2%) children for whom the source of infection was identified. An adult member with COVID-19 was the first case in 125 (66.8%) family clusters. Child-to-adult transmission was
found in one occasion only.
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Schwartz et al.
present an outbreak involving an adolescent index case and a family gathering with 20 exposed persons, leading to COVID-19 cases (n=12). All positive cases were among family members who stayed at the same house as the index case for the duration of their
stay. None of the exposed relatives who remained outdoors and maintained physical distance during family gathering developed symptoms.
IMMUNOLOGY
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Meng et al.
investigated the diagnostic value of SARS-CoV-2 IgM/IgG and nucleic acid detection in COVID-19. The authors retrospectively analyzed 652 suspected COVID-19 patients and 206 non-COVID-19 patients in Wuhan. Of the 652 suspected COVID-19 patients, 311 (47.7%)
were positive for IgM, and 592 (90.8%) were positive for IgG. There was a significant difference in the positive detection rate between the IgM and IgG test groups (P < 0.001). Using the RT-PCR results as a reference, the specificity, sensitivity, and accuracy
of IgM/IgG combined tests for SARS-CoV-2 infection were 98.5%, 95.8%, and 97.1%, respectively. Of the 415 suspected COVID-19 patients with negative nucleic acid test results, 366 had positive IgM/IgG tests with a positive detection rate of 88.2%.
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Iyer et al. measured plasma and/or serum antibody responses to the receptor-binding domain (RBD) of the spike (S) protein of SARS-CoV-2 in 343 North American
patients infected with SARS-CoV-2 (of which 93% required hospitalization) up to 122 days after symptom onset and compared them to responses in 1548 individuals whose blood samples were obtained prior to the pandemic. Findings suggest that RBD-targeted antibodies
are excellent markers of previous and recent infection, that differential isotype measurements can help distinguish between recent and older infections, and that IgG responses persist over the first few months after infection and are highly correlated with
neutralizing antibodies.
ZOONOSES
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Kumar et al presented a bioinformatics based method predicting susceptibility for SARS-CoV-2 infection in domestic and wildlife animals. The authors method investigated the predicted
the susceptibility of several animals (several species of primates, bears, a variety of rodents, camels, among others) for contracting SARS-CoV-2 infection. This method can be used as a screening tool for guiding viral RNA testing for domestic and wildlife
animals at risk of getting COVID-19. The authors also provide a list of the animals at risk of developing COVID-19 based on the susceptibility score.
DIAGNOSTICS
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Zhong et al
propose an approach for rapid and sensitive detection of SARS-CoV-2 with functionalized MNPs via the measurement of their magnetic response in an ac magnetic field. Experimental results demonstrate that the proposed approach allows the rapid detection
of mimic SARS-CoV-2 with a limit of detection of 0.084 nM (5.9 fmole). The proposed approach has great potential for designing a low-cost and point-of-care device for rapid and sensitive diagnostics of SARS-CoV-2.
CORONAVIROLOGY
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Panchin and Panchin
compare patterns of mutations that occurred before and after SARS-CoV-2 jumped to human hosts may reveal important evolutionary consequences of zoonotic transmission. We used publically available complete genomes of SARS-CoV-2 to calculate relative frequencies
of single nucleotide variations. We found a 9-fold excess of G–U transversions among SARS-CoV-2 mutations over relative substitution frequencies between SARS-CoV-2 and a close relative coronavirus from bats (RaTG13). This suggests that mutation patterns of
SARS-CoV-2 have changed after transmission to humans.
THERAPEUTICS
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Anil et al
examined the anti-inflammatory activity of cannabis on markers of immune responses associated with COVID-19 inflammation. Treatments with FCBD and phytocannabinoid standards that compose FCBD (FCBD:std) reduced IL-6, IL-8, C-C Motif Chemokine Ligands
(CCLs) 2 and 7, and angiotensin I converting enzyme 2 (ACE2) expression in the A549 cell line.
PUBLIC HEALTH RESPONSE
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Haston et al. For this study, survey data from October 2019 and June 2020 were compared to assess
changes in adults' remembering to wash their hands in six situations. Men, young adults aged 18-24 years, and non-Hispanic White (White) adults were less likely to remember to wash hands in multiple situations.
·
Kalaf-Hughes and Leiter,
using data from SafeGraph and the 2016 American National Election Study, demonstrate that the effect of stay-at-home policies on social distancing is reduced when gender resentment increases in states with female leaders. However, when gender resentment is
low, there is no difference in the effect of policies on behavior. This research has important implications for understanding unseen barriers that can mediate the efficacy of female political leaders.
·
Pan, et al.
investigate the associations between exposure to COVID-19–specific information and mental health (depression and sleep quality) and self-reported compliance with personal preventive measures (face mask wearing and hand sanitizing). This study provides
empirical evidence of how the amount, sources, and contents of information to which people were exposed influenced their mental health and compliance with personal preventive measures at the initial phase of work resumption in China
ECONOMICS
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Singh et al
examine the impact of the COVID-19 outbreak on the stock markets of G-20 countries. Results reveal that post the COVID-19 outbreak, stock markets all over the world performed badly and experienced negative returns. However, in the later stages of the
event window the stock markets were gradually recovering from the setback of the coronavirus outbreak, as indicated by positive cumulative average abnormal returns. The results of panel data regression report evidence in support of the stock market recovery
after the negative impact of COVID-19.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura
Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Alex Gilbert, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Network controllability-based prioritization of candidates for SARS-CoV-2 drug repositioning |
Ackerman, EE, Shoemaker, et al |
Viruses |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This research uses the existing methods for identifying influenza A virus drug targets that are applied to SARS-CoV-2–human
host protein interaction data to predict and prioritize candidate targets for drug repurposing. Two methods of network controllability determine the identity of proteins acting as regulators of the infected cell marked by changes to the network’s behavior
after the addition of virus–host protein interactions. Based on network topology and controllability, 16 proteins involved in translation, cellular transport, cellular stress, and host immune response are predicted as regulators of the SARS-CoV-2 infected
cell. Of the 16, eight are prioritized as possible drug targets where two, PVR and SCARB1, are previously unexplored. Known compounds targeting these genes are suggested for viral inhibition study. Prioritized proteins in agreement with previous analysis and
viral inhibition studies verify the ability of network controllability to predict biologically relevant candidates. |
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Adhikari, SP, Pariyar, et al |
Kathmandu University Medical Journal |
Public Health response| Interventions de santé publique |
This study analyzed the knowledge, attitude, practice and hospital experience regarding COVID-19 among post-partum mothers at a tertiary care center of
Nepal. A total of 203 post-partum women participated in the study. Almost all the participants had heard about COVID-19 (96.6%). A majority of them were aware about how COVID 19 gets transmitted and its preventive measures. Most of the participants (88.2%)
knew that COVID19 has effects on pregnancy. Almost all of participants (97%) wore mask during hospital stay. All of the women washed their hands with soap water or alcohol based sanitizer. A majority of the mothers (79.3%) wore mask while breastfeeding their
baby. |
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32980515; Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor |
Agarwal, S, Pethani, et al |
Bioorganic and Medicinal Chemistry Letters |
Therapeutics| Thérapeutique Animal model | Modèle animal |
NLRP3 inflammasome mediated release of interleukin-1β (IL-1β) has been implicated in various diseases, including COVID-19. In this study, rationally designed
alkenyl sulfonylurea derivatives were identified as novel, potent and orally bioavailable NLRP3 inhibitors. Compound 7 was found to be potent (IL-1β IC50 = 35 nM; IL-18 IC50 = 33 nM) and selective NLRP3 inflammasome inhibitor with excellent pharmacokinetic
profile having oral bioavailability of 99% in mice. © 2020 |
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Acute myelitis and SARS-CoV-2 infection. A new etiology of myelitis? |
Águila-Gordo, D, Manuel Flores-Barragán, et al |
Journal of Clinical Neuroscience |
Clinical data| Données cliniques |
This report presents report the case of an acute transverse myelitis (TM) in a patient with SARS-CoV-2 infection detected by the nasopharyngeal swab technique
but not in cerebrospinal fluid (CSF) analysis. Anti-herpes simplex virus (HSV) 1 and varicella-zoster IgM antibodies were not detected in serum samples and spinal and brain magnetic resonance imaging (MRI) showed no abnormal findings. |
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Al Kuwari, HM, Abdul Rahim, et al |
BMJ Open |
Epidemiology| Épidémiologie |
This case series defines the epidemiological curve of COVID-19 in Qatar and determines factors associated with severe or critical illness. Between 28
February and 18 April 2020, 5685 cases of COVID-19 were identified. Median age was 34 (IQR 28-43) years, 88.9% were male and 8.7% were Qatari nationals. Overall, 83.6% had no concomitant comorbidity, and 3.0% had three or more comorbidities. The overwhelming
majority (90.9%) were asymptomatic or with minimal symptoms, with 2.0% having severe or critical illness. Seven deaths were observed during the time interval studied. Presence of hypertension or diabetes was associated with a higher risk of severe or critical
illness, but age was not. The epidemiological curve indicated two distinct patterns of infection, a larger cluster among expatriate craft and manual workers and a smaller one among Qatari nationals returning from abroad during the epidemic. |
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Al-assaf, O, Mirza, et al |
HeartRhythm Case Reports |
Clinical data| Données cliniques |
This paper presents an atypical case of COVID-19 infection with subclinical myocarditis and intermittent complete atrioventricular
(AV) block to demonstrate the value of cardiac magnetic resonance imaging (cMRI) in detecting early cardiac involvement. |
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Albahli, S, Albattah, et al |
Journal of X-ray science and technology |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study aims to employ the advantages of computer vision and medical image analysis to develop an automated model
that has the clinical potential for early detection of novel coronavirus (COVID-19) infected disease. Among the three models, InceptionNetV3 yielded the best performance with accuracy levels of 98.63% and 99.02% with and without using data augmentation in
model training, respectively. All the performed networks tend to overfitting (with high training accuracy) when data augmentation is not used, this is due to the limited amount of image data used for training and validation. |
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Al-Hwiesh, A, Mohammed, et al |
Peritoneal Dialysis International |
Clinical data| Données cliniques |
Coronavirus Disease 2019 (COVID-19) is a pandemic disease that increased the burden on health-care system. In the Kingdom
of Saudi Arabia, 74,795 cases have been reported until 26 May 2020 and the number of cases is rapidly increasing. The mortality rate of COVID-19 worldwide is 6.37%. Here we report three cases of acute kidney injury (AKI) secondary to pneumonia of severe COVID-19;
they were treated with automated peritoneal dialysis (PD) with full recovery. To the best of our knowledge, few reports in the literature have discussed the use of PD in AKI secondary to COVID-19. © The Author(s) 2020. |
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Ali, SH, Foreman, et al |
JMIR Public Health Surveill |
Public Health response| Interventions de santé publique |
This study assessed sociodemographic predictors of the use and trust of different COVID-19 information sources, as
well as the association between information sources and knowledge and beliefs about the pandemic. The sample consisted of 11,242 participants. When combined, traditional media sources (television, radio, podcasts, or newspapers) were the largest sources of
COVID-19 information (91.2%). Among those using mainstream media sources for COVID-19 information (n=7811, 69.5%), popular outlets included CNN (24.0%), Fox News (19.3%), and other local or national networks (35.2%). The largest individual information source
was government websites (87.6%). They were also the most trusted source of information (43.3%), although the odds of trusting government websites were lower among males and those aged 40-59 years and ≥60 years compared to those aged 18-39 years. |
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Allam, AE, Assaf, et al |
RSC Advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study examined the activity of these compounds (3′-Hydroxy-4′-methoxy-chroman-7-O-β-d-glucopyranoside 4 , the
ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-d-glucopyranoside 3, ) to combat the COVID-19 outbreak. Docking study with Mpro of SARS-CoV-2 (PDBID:6LU7, and 6Y2F) showed that compound 3, its aglycone part, and
compound 4 have a strong binding mode to a protease receptor with key amino acids, especially Gln:166AA, and having a similar docking pose to co-crystalized ligands. Docking with the spike protein of SARS-CoV-2 illustrated that compounds 3 and 4 have a good
binding affinity to PDBID:6VSB through the formation of HBs with Asp:467A and Asn:422A. According to ROCS analysis, compounds 1, 3, and 4 displayed high similarities to drugs that prevent SARS-Co2 entry to the lung cells or block the inflammatory storm causing
lung injury. Compounds 3 and 4 are good candidates for drug development especially because they showed predicted activity against SARS-CoV-2 through different mechanisms either by preventing genome replication or by blocking inflammatory storm that trigger
lung injury. |
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Extracting a Knowledge Base of Mechanisms from COVID-19 Papers |
Amini, Aida, Hope, et al |
arXiv |
Public Health response| Interventions de santé publique |
This study pursued the use of methods for extracting diverse forms of mechanism relations from the natural language
of scientific papers. And sought to identify concepts in COVID-19 and related literature which represent activities, functions, associations and causal relations, ranging from cellular processes to economic impacts. Formulated a broad, coarse-grained schema
targeting mechanism relations between open, free-form entities. Curated a dataset of scientific papers annotated according to their novel schema. Using an information extraction model trained on this new corpus, constructed a knowledge base (KB) of 2M mechanism
relations. This model is able to extract relations at an F1 at least twice that of baselines such as open IE or related scientific IE systems. |
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Amoah, Isaac Dennis, Pillay, et al |
Research Square prepub |
Transmission Infection Prevention and Control/ Prévention et contrôle des infections
(IPAC/PCI) |
This study presents the first report of SARS-CoV-2 contamination on key contact surfaces in shared toilets, in the
city of Durban, using droplet digital PCR and assessed the probabilistic risks of COVID-19 infections. Approximately, 53-69% of the contact surfaces were contaminated, with SARS-CoV-2 viral loads per cm2 ranging from 25.9 to 132.69 gc/cm2. Toilet seats had
the highest contamination per cm2. The results suggested that the leading cause of contamination in shared toilets could be the shedding of the viral particles in feces and contaminated hands. Observed a significant reduction in viral loads on the contaminated
surfaces after cleaning, showing the potential of effective cleaning on the reduction of contamination of these surfaces. The probabilistic assessment showed a high potential for COVID-19 infections. Touching the internal latch of the toilet cubicle had the
highest risk of infections (4.3x10-2(6.0x10-4)) when a person uses the toilet once in a day, increasing to 1.0x10-1(1.4x10-3) for three uses in a day. |
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Anil, SeegehalliM, Shalev, et al |
Research Square prepub |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The purpose of this study was to examine the anti-inflammatory activity of cannabis on markers of immune responses
associated with Coronavirus disease 2019 (COVID-19) inflammation. An extract fraction from C. sativa Arbel strain (FCBD) substantially reduced dose dependently interleukin (IL) 6 and 8 levels in an alveolar epithelial (A549) cell line. FCBD contained cannabidiol
(CBD), cannabigerol (CBG) and tetrahydrocannabivarin (THCV), and multiple terpenes. Treatments with FCBD and phytocannabinoid standards that compose FCBD (FCBD:std) reduced IL-6, IL-8, C-C Motif Chemokine Ligands (CCLs) 2 and 7, and angiotensin I converting
enzyme 2 (ACE2) expression in the A549 cell line. Treatment with FCBD induced macrophages (differentiated KG1 cell line) polarization and phagocytosis in vitro, and increased CD36 and type II receptor for the Fc region of IgG (FcγRII) expression. FCBD treatment
also substantially increased IL-6 and IL-8 expression in macrophages. |
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Arafa, A, Mohammed, et al |
Journal of affective disorders |
Healthcare Response | Réponse des soins de santé |
This study selected two Middle East countries; Egypt and Saudi Arabia to investigate the psychological impacts of the
COVID-19 pandemic on their healthcare workers (HCWs). This study included 426 HCWs (48.4% physicians, 24.2% nurses, and 27.4% other HCWs). Of them, 69% had depression, 58.9% had anxiety, 55.9% had stress, and 37.3% had inadequate sleeping (<6 h/day). Female
sex, age ≤30 years, working in Egypt, attending emergency and night shifts, watching/reading COVID-19 news ≥2 h/day, and not getting emotional support from family, society, and hospital were associated with a high likelihood of depression, anxiety, stress,
and inadequate sleeping. The cross-sectional design restricted the authors ability to distinguish between preexisting and emerging psychological symptoms. |
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Asai, N, Sakanashi, et al |
Journal of Infection and Chemotherapy |
Clinical data| Données cliniques |
The novel coronavirus disease 2019 (COVID-19) is diagnosed by positive result of reverse transcription polymerase chain
reaction (RT-PCR) for the novel coronavirus. We concluded that cycle threshold value (Ct-value) of real-time RT-PCR (rRT-PCR) assay could decrease as patients recover. Results of rRT-PCR assay could remain positive among asymptomatic patients for longer than
2 weeks. The discharge criteria of COVID-19 patients using a negative result of rRT-PCR should be reconsidered. © 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases |
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A new emergency response of spherical intelligent fuzzy decision process to diagnose of COVID19 |
Ashraf, S, Abdullah, et al |
Soft Computing |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission |
Fuzzy set and their extension are found to be an effective tool to describe and reduce the uncertainty in data information.
This study used fuzzy logic to develop fuzzy mathematical model for control of transmission and spreading of COVID19. The proposed research work is on fuzzy mathematical model of intelligent decision systems under the spherical fuzzy information. In the proposed
work, the authors developed a newly and generalized technique for COVID19 based on the technique for order of preference by similarity to ideal solution (TOPSIS) and complex proportional assessment (COPRAS) methods under spherical fuzzy environment. An illustrative
of the emergency situation of COVID-19 is given for demonstrating the effectiveness of the suggested method, along with a sensitivity analysis and comparative analysis, showing the feasibility and reliability of its results. |
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Asiamah, N, Opuni, et al |
Community Ment Health J |
Public Health response| Interventions de santé publique |
This study assessed the behavioral outcomes of Coronavirus 2019 (COVID-19) social distancing protocols and their influences
on mental health. An online survey hosted by Survey Monkey was utilized to collect data from residents of three Ghanaian cities of Accra, Kumasi and Tamale. A total of 621 surveys were analyzed, with a sensitivity analysis utilized to select covariates for
the regression model. The average age of participants was about 36 years. Findings indicate that reduced physical activity time and a change in sexual activity and smoking frequency are some short-term changes in behavior resulting from social isolation during
the lockdown. An increase in sedentary behavior had a negative influence on mental health. For the most part, changes in behaviors in the short-term were associated with lower mental health scores. The study implied that COVID-19 social distancing measures
should be implemented alongside public education for discouraging unhealthy changes in behaviors. |
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Turning
on a dime-pre- and post-COVID-19 consultation patterns in an urban general practice |
Atmore, C, Stokes, et al |
N Z Med J |
Healthcare Response | Réponse des soins de santé |
This study investigated changes in general practice consultation patterns in response to reduced face-to-face patient
contact during the COVID-19 pandemic. Twenty percent of patients had contact with the practice in both samples, with similar proportions by age, gender, ethnicity, deprivation and presence of multimorbidity or mental health diagnoses. Similar numbers of acute
illness, accident-related and prevention patient contacts occurred in both samples, with more long-term condition-related contact in 2020. While 70% of patient contacts were face-to-face in 2019, 21% were face-to-face in 2020. Most acute illness, accident-related
and long-term condition-related contacts were able to be provided through virtual means, but most prevention-related contacts were face-to-face. |
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Awareness as the most effective measure to mitigate the spread of COVID-19 in Nigeria |
Baba, IA, Baleanu, et al |
Computers, Materials and Continua |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This research studied the dynamics of the spread of COVID-19 in Nigeria and showed the effectiveness of awareness and
the need for relevant authorities to engage themselves more in enlightening people on the significance of the available control measures in mitigating the spread of the disease. Two equilibrium solutions; Disease free equilibrium and Endemic equilibrium solutions
were calculated and their global stability analysis was carried out. Basic reproduction ratio (RR0 ) was also obtained, in this research RR0 = 3.0784. From the simulation result, it was shown that to mitigate the spread of COVID-19 in Nigeria there is need
for serious awareness programs to enlighten people on the available control measures; social distancing, self-isolation, use of personal protective equipment (such as face mask, hand globes, overall gown, etc.), regular hand washing using soap or sanitizer,
avoiding having contact with person showing the symptoms and reporting any suspected case. |
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Bagheri, M, Niavarani, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study screened 1930 FDA-approved ligands for the selection of optimal ones blocking this interaction. Virtual
screening predicted top 25 ligands docking to any of the reported binding sites. After exclusion of those ligands which were unsuitable for systemic use, the remaining 69 RBD-ligand complexes were screened based on the masking capacity of the amino acid residues
engaged in RBD-hACE2 interaction, excluding 47 RBD-ligand complexes. A short molecular dynamics (MD) simulation analysis identified 11 globally stable complexes with the lowest RMSD (root-mean-square deviation). Next, a moderately long MD analysis revealed
those six RBD-ligand complexes with the lowest RMSD variation, as a measure of global stability. Finally, a long MD analysis revealed two select candidate ligands, including ritonavir and naloxegol, highly stabilizing those key residues engaged in RBD-hACE2
interaction. |
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Balbi, M, Caroli, et al |
Eur Radiol |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study aimed to evaluate the inter-rater agreement of chest X-ray (CXR) findings in COVID-19 and to determine the
value of initial CXR along with demographic, clinical, and laboratory data at emergency department (ED) presentation for predicting mortality and the need for ventilatory support. GGO admixed with consolidation (n = 235, 69%) was the most common CXR finding.
The inter-rater agreement was almost perfect for type of parenchymal opacity (κ = 0.90), Brixia score (ICC = 0.91), and percentage of lung involvement (ICC = 0.95). The Brixia score (OR: 1.19; 95% CI: 1.06, 1.34; p = 0.003), age (OR: 1.16; 95% CI: 1.11, 1.22;
p < 0.001), PaO(2)/FiO(2) ratio (OR: 0.99; 95% CI: 0.98, 1; p = 0.002), and cardiovascular diseases (OR: 3.21; 95% CI: 1.28, 8.39; p = 0.014) predicted death. Percentage of lung involvement (OR: 1.02; 95% CI: 1.01, 1.03; p = 0.001) and PaO(2)/FiO(2) ratio
(OR: 0.99; 95% CI: 0.99, 1.00; p < 0.001) were significant predictors of the need for ventilatory support. |
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Echocardiographic features of patients with COVID-19 infection: a cross-sectional study |
Barman, HA, Atici, et al |
Int J Cardiovasc Imaging |
Clinical data| Données cliniques |
The aim of this study was to investigate the echocardiographic features in COVID-19 patients between severe and non-severe
groups. A total of 90 patients hospitalized for COVID-19 were included in this study. The mean age of the severe group (n = 44) was 63.3 ± 15.7 years, and 54% were male. The mean age of non-severe group (n = 46) was 49.7 ± 21.4 years, and 47% were male. In
the severe group, RV and LV diameters were larger (RV, 36.6 ± 5.9 mm vs. 33.1 ± 4.8 mm, p = 0.003; LV 47.3 ± 5.8 mm vs. 44.9 ± 3.8 mm, p = 0.023), the LE ejection fraction (LVEF) and the RV fractional area change (RV-FAC) were lower (LVEF, 54.0 ± 9.8% vs.
61.9 ± 4.8%, p < 0.001; RV-FAC, 41.4 ± 4.1% vs. 45.5 ± 4.5%, p < 0.001), and pericardial effusions were more frequent (23% vs. 0%) compared to patients in the non-severe group. A multiple linear regression analysis determined that LVEF, right atrial diameter,
high-sensitivity troponin I, d-dimer, and systolic pulmonary artery pressure, were independent predictors of RV dilatation. The results demonstrate that both right and left ventricular functions decreased due to COVID-19 infection in the severe group. 2DE
is a valuable bedside tool and may yield valuable information about the clinical status of patients and their prognoses. |
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Basnet, S, Dahal, et al |
Kathmandu University Medical Journal |
Healthcare Response | Réponse des soins de santé |
The purpose of this cross-sectional study was to assess the knowledge, attitude, and practices (KAP) related to COVID-19
among healthcare personnel. Among 220 participants, the majority were nurses (60%) followed by doctors (27.7%), paramedics (10%) and technicians (2.3%). The results showed that 68.6% of healthcare personnel had a good knowledge with appropriate practices (98.5%)
and negative attitude (59.3%). In the multivariate binary logistic analysis, the healthcare workers with the clinical experience level of one to five years (OR:.42, 95% CI:.19-.96) and more than 5 years (OR:.16, 95% CI:.04-.63) were significantly associated
with negative attitude. The confidence score for managing COVID-19 (OR:1.16, 95% CI:1.02-1.34) was significantly associated with an optimistic attitude. |
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Ensemble Machine Learning Methods for Modeling COVID19 Deaths |
Bathwal, R, C |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Using a hybrid of machine learning and epidemiological approaches, we propose a novel data-driven approach in predicting
US COVID-19 deaths at a county level. The model gives a more complete description of the daily death distribution, outputting quantile-estimates instead of mean deaths, where the model's objective is to minimize the pinball loss on deaths reported by the New
York Times coronavirus county dataset. The resulting quantile estimates accurately forecast deaths at an individual-county level for a variable-length forecast period, and the approach generalizes well across different forecast period lengths. We won the Caltech-run
modeling competition out of 50+ teams, and our aggregate is competitive with the best COVID-19 modeling systems (on root mean squared error). |
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Beketova TV, tvbek, rambler ru, et al |
Nauchno-Prakticheskaya Revmatologiya |
Clinical data| Données cliniques |
Article in Russian. This paper presents a case report about COVID-19 in a 59-year-old female with associated systemic
vasculitis (AAV) in remission, who was previously treated with rituximab (RTM). COVID-19 was diagnosed one month after the last RTM administration; there were moderate bilateral pneumonia, fever, and extrapulmonary manifestations, including lesions of the
gastrointestinal tract and central nervous system. |
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Safety and 30-day outcomes of tracheostomy for COVID-19: a prospective observational cohort study |
Breik, O, Nankivell, et al |
British journal of anaesthesia |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We developed both a dedicated airway team and coordinated education programme to facilitate ward management of tracheostomised
COVID-19 patients. Here, we report outcomes in the first 100 COVID-19 patients who underwent tracheostomy at our institution. A total of 164 patients with COVID-19 were admitted to the ICU between March 9, 2020 and April 21, 2020. A total of 100 patients (mean
standard deviation] age: 55 12] yr; 29% female) underwent tracheostomy; 64 (age: 57 14] yr; 25% female) did not undergo tracheostomy. Despite similar APACHE-II scores, 30-day survival was higher in 85/100 (85%) patients after tracheostomy, compared with 27/64
(42%) non-tracheostomised patients {relative risk: 3.9 (95% confidence intervals CI]: 2.3–6.4); P<0.0001}. In patients with APACHE-II scores ≥17, 68/100 (68%) tracheotomised patients survived, compared with 12/64 (19%) non-tracheotomised patients (P<0.001).
Tracheostomy within 14 days of intubation was associated with shorter duration of ventilation (mean difference: 6.0 days 95% CI: 3.1–9.0]; P<0.0001) and ICU stay (mean difference: 6.7 days 95% CI: 3.7–9.6]; P<0.0001). No healthcare workers developed COVID-19. |
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Living with Chronic Fatigue Syndrome during lockdown and a global pandemic |
Brewer, G, Stratton, et al |
Fatigue: Biomedicine, Health and Behavior |
Public Health response| Interventions de santé publique |
The present study investigates the experiences of those with Chronic Fatigue Syndrome during the COVID-19 pandemic.
In the present study, we identified fifty online forum (Reddit) posts, discussing the personal lived experience of Chronic Fatigue Syndrome during lockdown and the global pandemic. Four themes were extracted from the data. These were (i) Symptom Change, (ii)
Social Interactions, (iii) Comparing Experiences, and (iv) Positive Consequences. Themes highlighted both positive and negative experiences of the COVID-19 pandemic. For example, whilst some people reported more severe symptoms, lockdown also provided more
accessible opportunities to interact (i.e. online videocalls). |
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Typical CT findings of COVID-19 pneumonia in patients presenting with repetitive negative RT-PCR |
Brogna, B, Bignardi, et al |
Radiography |
Clinical data| Données cliniques |
We report three patients with history of fever and different clinical signs. During the height of the pandemic in Italy
(March to May 2020), these patients underwent chest computed tomography (CT) scans that showed lung alterations typical of COVID-19 with multiple negative RT-PCR tests and positive serology for SARS-CoV-2. Two of the three patients showed residual pneumonia
on CT after the onset of the first clinical signs. One patient presented with diarrhoea without respiratory symptoms. These cases suggest that in the COVID-19 pandemic period, to provide an earlier specific treatment in patients with positive serology, a chest
CT scan can be useful in those presenting with a fever or a history of fever associated with persistent mild respiratory symptoms or with abdominal complaints despite repeated negative RT-PCR results. |
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Continuous positive airway pressure in Covid-19 patients with moderate-to-severe respiratory
failure |
Brusasco, C, Corradi, et al |
Eur Respir J |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We retrospectively reviewed the records of patients admitted to the Covid-19 unit of the 400-bed Galliera Hospital
of Genoa between March 16 and April 12, 2020. Our main finding was that the vast majority of Covid-19 patients treated by CPAP recovered from moderate-to-severe AHRF, including cases with gas exchange and radiological findings similar to those considered as
indications for IMV in typical adult respiratory distress syndrome (ARDS). |
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Compassionate Use of Remdesivir in Pregnant Women with Severe Covid-19 |
Burwick, RM, Yawetz, et al |
Clin Infect Dis |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We describe outcomes in the first 86 pregnant women with severe COVID-19 who were treated with remdesivir. Nineteen
of 86 women delivered before their first dose and were reclassified as immediate "postpartum" (median postpartum day=1; range 0-3). At baseline, 40% of pregnant women (median gestational age 28 weeks) required invasive ventilation, in contrast to 95% of postpartum
women (median gestational age at delivery 30 weeks). By Day 28 of follow-up, the level of oxygen requirement decreased in 96% and 89% of pregnant and postpartum women, respectively. Among pregnant women, 93% of those on mechanical ventilation were extubated,
93% recovered, and 90% were discharged. Among postpartum women, 89% were extubated, 89% recovered, and 84% were discharged. Remdesivir was well tolerated, with a low incidence of serious adverse events (16%). Most adverse events were related to pregnancy and
underlying disease; most laboratory abnormalities were Grades 1 or 2. There was one maternal death attributed to underlying disease and no neonatal deaths. |
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Cadegiani, FlavioA, Goren, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The objective of the present observational study was to characterize prospectively clinical features and predictors
in males during early COVID-19, and to evaluate whether the combination of more sensitive case-detection, early diagnosis and early pharmacological approaches would lead to improved clinical outcomes. A total of 305 males were enrolled, including 192 non-AGA,
71 AGA non-ARi and 52 AGA-5ARi. The prevailing symptoms were anosmia (68.9%), ageusia (61.2%), headache (37.5%), hyporexia (37.5%), fatigue (35.2%), dry cough (35.2%), fever or “feverish” (33.9%), thoracic pain (32.4%), conjunctival hyperemia (29.5%), weakness
(29.5%), nasal congestion or rhinorrhea (28.6% and myalgia (26.3%). ARi users remained asymptomatic throughout COVID-19 treatment in 82.7% (43 of 52 males), and the only symptoms present in more than two patients were anosmia and ageusia. Thoracic, upper back,
lower back pain, arthralgia affected a higher percentage of AGA no-5ARi than non-AGA males (all p 0.9). None of the patients required hospitalization and mechanical ventilation, or progressed to more severe states. The combination of more sensitive and earlier
diagnosis of COVID-19 with a variety of drug combinations with preliminary demonstration of direct or indirect antiviral activity against SARS-CoV-2 demonstrated indisputable improved COVID-19 related clinical outcomes compared to the extensively described
COVID-19 clinical course, and avoided the progression to more severe state in all patients included in the present analysis, independently of risk factors, demonstrating that any additional risk factor can be completely mitigated by the combination of more
sensitive clinical suspect with early pharmacological approaches. |
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Malignant spinal cord compression (MSCC) presentation before and during Covid-19 |
Cameron, J |
Journal of Radiotherapy in Practice |
Healthcare Response | Réponse des soins de santé |
This audit compares the number of patients treated for malignant spinal cord compression (MSCC) before and during Covid-19,
their treatment regimes and 30-day mortality rates to assess if the pandemic affected the treatment and the number of patients referred for palliative radiotherapy. The results have demonstrated fewer patients presenting during the pandemic and this may be
due to patients not wishing to utilise the National Health Service (NHS) during this time. It also highlighted the need to reduce the treatment duration to minimise hospital attendance and lessen the potential for exposure to Covid-19. |
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Cantos, JO, Camacho, et al |
Investigaciones Geograficas (Spain) |
Epidemiology| Épidémiologie |
Article in Spanish. The study of parameters such as temperature, humidity and radiation in the months of February and
March 2020, as well as a correlative analysis with other variables of different themes, aims to weight the weight that these variables may have had in the expansion of this pathogen in the province of Alicante. The results obtained suggest, in a preliminary
way, that the only variable that is related to the contagion rate and the death rate are the maximum temperatures. This fact could be related to the climate niche of the coronavirus, which could be decisive in its expansion worldwide. The lack of information
on the previous rates at the municipal level, as well as the inexistence of mobility data at such a low scale, makes it difficult to establish definitive conclusions. |
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Carlberg, DJ, Bhat, et al |
Journal of Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
This study aimed to describe and assess the early results of a novel telehealth workflow in which remote providers
collaborate with in-person nursing to evaluate and discharge well-appearing, low-risk ED patients with suspected COVID-19 infection. Among 302 patients evaluated by telehealth, 153 patients were evaluated and discharged by a telehealth provider with reductions
in ED-LOS, PPE use, and close contact with health care personnel. These patients had a 62.5% shorter ED-LOS compared with other Emergency Severity Index level 4 patients seen over the same time period. Telehealth use for these 153 patients saved 413 sets of
PPE. We observed a 3.9% 72-h revisit rate. One patient discharged after telehealth evaluation was hospitalized on a return visit 9 days later. |
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Carrion, DM, Mantica, et al |
Actas Urologicas Espanolas |
Healthcare Response | Réponse des soins de santé |
We hypothesized that the recent COVID-19 pandemic may lead to a delay in renal colic patients presenting to the Emergency
Department due to the fear of getting infected. This delay may lead to a more severe clinical condition at presentation with possible complications for the patients. A total of 397 patients presented to Emergency Department with radiology confirmed urolithiasis
and were included in the study. The number of patients presenting to Emergency Department with renal/ureteric colic was 285 (71.8%) patients in Group A and 112 (28.2%) patients in Group B (p < 0.001). The number of patients reporting a delay in presentation
was 135 (47.4%) in Group A and 63 (56.3%) in Group B (p = 0.11). At presentation, there were no statistical differences between Group A and Group B regarding the serum creatinine level, C reactive protein, white blood cell count, fever, oliguria, flank pain
and hydronephrosis. In addition, no significant differences were observed with the length of stay, Urology department admission requirement and type of therapy. |
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Chandel, V, Banerjee, et al |
|
Public health interventions*| Interventions de santé publique |
In the absence of a definitive and an official vaccine for the infection, practicing social distancing has proved to
be an effective norm to prevent the risk of infection. In this paper, we present 'ProxiTrak', a smartphone based solution for an enterprise scenario capable of not only tracing the chain of possible infection transmission among a set of population, but also
guiding the users towards following social distancing norms by alerting them in real-time about any possible violation of proximity norms on their smartphones. We devise an effective classification model to make proximity decisions on the smartphone itself
using Received Signal Strength Indicator (RSSI) data of on-board Bluetooth Low Energy (BLE) module using multiple mobile devices in different environments, with novel addition of using temporal features from BLE data to boost the model's accuracy. |
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Chang, WH |
Taiwanese Journal of Obstetrics and Gynecology |
Healthcare Response | Réponse des soins de santé |
This article uses two actual cases from a medical center in northern Taiwan to discuss the impact of COVID-19 on pregnant
women. This case study serves to highlight that, to ensure more effective coordination during severe epidemics, a comprehensive infection prevention plan should be formulated. |
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Chaudhary, R, Bakhshi, et al |
Investment Management and Financial Innovations |
Economics | Économie |
The current empirical study attempts to analyze the impact of COVID-19 on the performance of the Indian stock market
concerning two composite indices (BSE 500 and BSE Sensex) and eight sectoral indices of Bombay Stock Exchange (BSE). The daily data from January 2019 to May 2020 have been considered in this study. GLS regression has been applied to assess the impact of COVID-19
on the multiple measures of volatility, namely standard deviation, skewness, and kurtosis of all indices. All indices’ key findings show lower mean daily return than specific, negative returns in the crisis period compared to the pre-crisis period. The standard
deviation of all the indices has gone up, the skewness has become negative, and the kurtosis values are exceptionally large. The relation between indices has increased during the crisis period. The Indian stock market depicts roughly the same standard deviation
as the global markets but has higher negative skewness and higher positive kurtosis of returns, making the market seem more volatile. |
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Chen, Shanquan, Jones, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
We investigated what factors contributed to excess deaths of older patients during the initial 2020 lockdown beyond
those attributable to confirmed COVID-19. We hypothesized that both physical diseases and mental disorders would contribute. Methods: We did a retrospective cohort study using data from the electronic clinical records from Cambridge and Peterborough NHS Foundation
Trust (CPFT), UK (catchment area population ~ 0.86 million). Eligible patients were aged 65 years or over at baseline with at least 14 days’ follow-up, excluding patients diagnosed with confirmed or suspected SARS-CoV-2 infection. We defined a cohort exposed
to COVID-19 lockdown comprising patients recorded in CPFT between March 23, 2020 and May 19, 2020, and compared their mortality with an cohort recorded in CPFT between January 13, 2020 and 10 March, 2020, unexposed to lockdown. Findings: No significant additional
death risks were identified from physical comorbidities. Interpretation: During lockdown people with dementia or severe mental illness had a higher risk of excess death. This study suggests that such patients require additional support during a societal response
to this and similar epidemics/pandemics. |
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Cherri, S, Lemmers, et al |
Therapeutic Advances in Medical Oncology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We provide our experience in a center with high access for patients with COVID-19-associated pneumonia in Lombardy,
Italy. We conducted a retrospective study using a prospectively maintained database of patients admitted to our hospital between 25 February 2020 and 9 April 2020 with a confirmed diagnosis of COVID-19 pneumonia. Results: A total of 53 patients with a history
or current oncological disease were included in this study. The mortality rate of the total number of cancer patients is about twice as high as that of non-oncological patients admitted to our hospital with a diagnosis of COVID-19. Conclusion: The presence
of active oncological disease is independently related to mortality as well as age and diabetes. The majority of patients who died were frail. |
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In silico molecular docking: Evaluation of coumarin based derivatives against SARS-CoV-2 |
Chidambaram, SK, Ali, et al |
Journal of Infection and Public Health |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The present study, aims to forecast theoretical assembly for the protease of COVID-19 and to discover advance whether
this protein may assist as a target for protease inhibitors such as psoralen, bergapten, imperatorin, heraclenin, heraclenol, saxalin, oxepeucedanin, angelicin, toddacoumaquinone, and aesculetin. The docking score of these natural coumarin analogues compared
with standard Hydroxychloroquine. Whereas the 3D assembly of main protease of SARS coronavirus was forecast with SWISS MODEL web server, and molecular interaction studies amongst target protein and ligands were done with AutoDock Vina software. Results: The
study more exposed that all the inhibitors acquired with negative dock energy against the target protein. Molecular docking investigation displayed that natural coumarin analogue toddacoumaquinone displayed a remarkable inhibition ability with the binding
energy of −7.8 kcal/mol than other compounds against main protease of SARS coronavirus. |
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32983915; COVID-19 Outbreak, Mitigation, and Governance in High Prevalent Countries |
Chien, LC, Lin, et al |
Annals of global health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study aims to investigate the association between governance and the trend of COVID-19 incidence in countries
with the highest prevalence. We hypothesized that countries with better governance are more likely to mitigate the spread of COVID-19 than countries with worse governance. Methods: We analyzed 62 most prevalent countries with at least 10,000 accumulative confirmed
cases from January 22 to June 15, 2020. Countries were further grouped into three different levels of governance, identified outbreak and mitigation periods using the joinpoint regression model, and compared the number of days and average daily percent change
in incidence in two periods by governance level using the one-way analysis of variance. Findings: In the outbreak period, better governance countries had a more rapid increase but a shorter outbreak period (71.2 days) than countries with fair (93.5 days)
and worse (90.8 days) governance. Most countries with better governance (84.0%) revealed a declining trend in COVID-19 incidence, while such a trend was less than half of fair and worse governance countries (38.5%-41.7%). |
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Cillóniz, C, Torres, et al |
Archivos de Bronconeumologia |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aim to describe biological features and outcomes of 240 patients admitted for SARS-CoV-2 pneumonia, as well as identify
predictors of intensive care unit (ICU) admission, need for invasive mechanical ventilation (IMV) and in-hospital mortality. For this retrospective, observational study, all consecutive patients with laboratory-confirmed SARS-CoV-2 infection and pneumonia,
who visited the emergency department and were subsequently admitted to the hospital between February 28th and April 21st, 2020, were included. When compared to non-ICU patients, ICU-admitted patients were more likely to be men and have higher body mass index
(BMI). ICU-admitted patients also showed higher levels of creatinine, C-reactive protein, neutrophils, lactate dehydrogenase (LDH), white blood cell count, troponin, D-dimer, ferritin, and troponin. No significant differences were observed in therapies administered
to ICU-admitted and non-ICU patients. |
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Naloxone Use by Emergency Medical Services During the COVID-19 Pandemic: A National Survey |
Cone, DC, Bogucki, et al |
J Addict Med |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
We sought to determine changes in overdose events and naloxone administration practices by EMS clinicians. METHODS:
Between April 29, 2020 and May 15, 2020, we surveyed directors of EMS fellowship programs across the US about how overdose events and naloxone administration practices had changed in their catchment areas since March 2020. RESULTS: Based on 60 respondents
across all regions of the country, one fifth of surveyed communities have experienced an increase in opioid overdoses and events during which naloxone was administered, and 40% have experienced a decrease. The findings varied by region of the country. Eighteen
percent of respondents have discouraged or prohibited the use of intranasal naloxone with 10% encouraging the use of intramuscular naloxone. |
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Therapeutic effects of adenosine in high flow 21% oxygen aereosol in patients with Covid19-pneumonia |
Correale, P, Caracciolo, et al |
PLoS One |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This off label-treatment was based on preclinical studies in mice with LPS-induced ARDS, where inhaled adenosine/A2AR
agonists protected oxygenated lungs from the deadly inflammatory damage. The treatment was allowed, considering that adenosine has several clinical applications. PATIENTS AND TREATMENT: Fourteen consecutively enrolled patients with Covid19-related interstitial
pneumonitis and PaO2/FiO2 ratio 30%) in the PaO2/FiO2-ratio was reported in 13 out of 14 patients treated with adenosine compared with that observed in 7 out of52 patients in the control within 15 days. Additionally, we recorded a mean PaO2/FiO2-ratio increase
in patients receiving adenosine and no change in the control group. A radiological response was demonstrated in 7 patients who received adenosine, while SARS-CoV-2 RNA load rapidly decreased in 13 cases within 7 days while no changes were recorded in the control
group within 15 days. There was one Covid-19 related death in the experimental group and 11 in the control group. |
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Optimal control of vaccination and plasma transfusion with potential usefulness for COVID-19 |
Couras, Juliana, Area, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique Therapeutics| Thérapeutique |
We introduce two control functions in the compartmental SEIR model representing vaccination and plasma transfusion.
Optimal control problems are proposed to study the effects of these two control measures, on the reduction of infected individuals and increase of recovered ones, with minimal costs. Up to our knowledge, the plasma transfusion treatment has never been considered
as a control strategy for epidemics mitigation. The proposed vaccination and treatment strategies may have a real application in the challenging and hard problem of controlling the COVID-19 pandemic. Of the controls employed, the combined action of vaccination
and plasma |
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Cransac-Miet, A, Zeller, et al |
International journal of cardiology |
Public Health response| Interventions de santé publique |
We aimed to evaluate the impact of coronavirus disease 2019 (COVID-19)-related lockdown on adherence to lifestyle and
drug regimens in stay-at-home chronic coronary syndromes patients living in urban and rural areas. Methods: A cross-sectional population-based study was perfomed in patients with chronic coronary syndromes. A sample of 205 patients was randomly drawn from
the RICO (Observatoire des infarctus de Côte d'Or) cohort. Eight trained interviewers collected data by phone interview during week 16 (April 13 to April 19), i.e. 4 weeks after implementation of the French lockdown (start March 17, 2020). Results: All 166
(85%) patients taking aspirin continued their prescribed daily intake. Lifestyle rules were less respected since almost half (45%) declared >25% reduction in physical activity, 26% of smokers increased their tobacco consumption by >25%, and 24% of patients
increased their body weight > 2 kg. The decrease in physical activity and the increase in smoking were significantly greater in urban patients. |
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Management and use of filter masks in the “none-medical” population during the Covid-19 period |
Cumbo, E, Scardina, et al |
Safety Science |
Public Health response| Interventions de santé publique |
In this study, conducted in Italy during the so-called phase 2, the behavior of the population outside their homes
was observed, focusing on how the mask was worn and managed. All data were collected in a period of 12 days from 9 am to 8 pm; children and people with special needs were excluded as well as citizen observed while they were inside their cars. Out of a total
of 1034 subjects observed, the following results were noted: 12 subjects were on the street without any mask, therefore the citizens who wore one were 1022; 622 people wore a surgical mask; 118 people wore a FFP2/FFP3 type filter mask without the valve, 129
people wore a FFP2/FFP3 type filter mask with valve, 153 people wore a clearly self-made mask with fabric or had fabrics such as scarves fitted in front of the mouth and/or nose. Only 264 showed an exemplary behavior by wearing the mask correctly, covering
the nose and chin, and only 336 people during the entire period of observation (60 s) did not touch it. |
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Czerny, M, van den Berg, et al |
J Card Surg |
Healthcare Response | Réponse des soins de santé |
A web-based expert panel discussion on April 18, 2020, where eight experts were invited to share their experience with
COVID-19 disease touching several aspects of aortic medicine. After each talk, specific questions were asked by the online audience, and results were immediately evaluated and shared with faculty and participants. RESULTS: As of April 18, 73.3% answered that
more than 200 patients have been treated at their respective settings. Sixty-four percent were reported that their hospital was well prepared for the pandemic. In 57.7%, the percentage of infected healthcare professionals was below 5% whereas 19.2% reported
the percentage to be between 10% and 20%. Sixty-seven percent reported the application of extracorporeal membrane oxygenation in less than 2% of COVID-19 patients whereas 11.8% reported application in 5%-10% of COVID-19 patients. Thirty percent of participants
reported the occurrence of pulmonary embolism in COVID-19 patients. Three percent reported to have seen aortic ruptures in primarily elective patients having been postponed because of the anticipated need to provide sufficient ICU capacity because of the pandemic.
Nearly 70% reported a decrease in acute aortic syndrome referrals since the start of the pandemic. |
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Daoust, Jean-François, Bastien, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
In this research note, we present the main findings of a survey experiment where citizens were exposed to a projection
of the total number of deaths in Canada. We manipulated the exclusion and inclusion of graphically depicted confidence intervals in order to isolate the effect of uncertainty. Our results show that accounting for uncertainty does not change citizens' perceptions
of projections’ reliability or support for preventive public health measures. We make use of an online survey experiment, conducted in Canada by the polling firm Léger using a quota-based approach to collect a nationally representative sample of 1002 respondents.
Respondents took the survey between June 16 and 24, 2020. |
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Dar-Odeh, N, Babkair, et al |
Eur J Dent |
Healthcare Response | Réponse des soins de santé |
This study aimed to analyze Jordanian dentists' inquiries on oral infections and antimicrobial prescribing using dental
professional WhatsApp groups during coronavirus disease lockdown period. MATERIALS AND METHODS: Three professional WhatsApp groups of Jordanian dentists were reviewed and analyzed for inquiries posted during the period from January to May 2020. Inquiries were
sent from patients to their dentists who posted these inquiries to the professional WhatsApp dental groups for consultation and professional advice. RESULTS: There was a total of 32 inquiries regarding oral lesions and 11 consultations regarding prescribing
and dental management of medically compromised patients giving a total of 43 consultations. Among which there were 19 inquiries on oral infections and 9 inquiries on antimicrobial prescribing giving a total of 28 consultations. Most common inquiries were on
bacterial infections (localized dentoalveolar abscess, pericoronitis, cellulitis, and lymphoid hyperplasia of the tongue), viral herpetic infections, and Candida infections (erythematous and pseudomembranous candidiasis). |
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Das, A, Sil, et al |
Prim Care Companion CNS Disord |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to evaluate the mental health status of pan-Indian frontline doctors combating the
COVID-19 pandemic. METHODS: A cross-sectional, observational study was conducted among frontline doctors of tertiary care hospitals in India from May 23, 2020, to June 6, 2020. Doctors involved in clinical services in outpatient departments, designated COVID-19
wards, screening blocks, fever clinics, and intensive care units completed an online questionnaire. The 9-item Patient Health Questionnaire and the Perceived Stress Scale were used to assess depression and perceived stress. RESULTS: The results of 422 responses
revealed a 63.5% and 45% prevalence of symptoms of depression and stress, respectively, among frontline COVID-19 doctors. Postgraduate trainees constituted the majority (45.5%) of the respondents. Moderately severe and severe depression was noted in 14.2%
and 3.8% of the doctors, respectively. Moderate and severe stress was noted in 37.4% and 7.6% of participants, respectively. |
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Dashash, M, Almasri, et al |
Eastern Mediterranean Health Journal |
Healthcare Response | Réponse des soins de santé |
The study aimed to identify essential competencies required for approaching patients with COVID-19. Methods: All postgraduate
health professionals at the Syrian Virtual University SVU (n=28) were invited to participate in the study during the Covid-19 lockdown in 2020, resulting in 20 postgraduates accepting. Results: Fifty-two essential competencies were identified; 7 competencies
on etiology, 7 related to assessment and diagnosis, 34 related to management, and 4 related to prognosis Conclusion: It is hoped that the identified competencies would help health professionals to deliver the best health care for COVI-19 patients, as well
as help policy-makers to support comprehensive training programmes that can equip health professionals with the required competencies to fight the pandemic. |
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de Azambuja, E, Brandão, et al |
ESMO open |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We report a population-based analysis of patients hospitalised with COVID-19 with prior or current solid cancer versus
those without cancer. METHODS: We analysed data of adult patients registered until 24 May 2020 in the Belgian nationwide database of Sciensano. The primary objective was in-hospital mortality within 30 days of COVID-19 diagnosis among patients with solid
cancer versus patients without cancer. Severe event occurrence, a composite of intensive care unit admission, invasive ventilation and/or death, was a secondary objective. RESULTS: Patients with cancer were older and presented with less symptoms/signs and
lung imaging alterations. The 30-day in-hospital mortality was higher in patients with solid cancer compared with patients without cancer. This population-based analysis demonstrates that solid cancer is an independent adverse prognostic factor for in-hospital
mortality among patients with COVID-19. |
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Modeling the incidence and death rates of COVID-19 pandemic in different regions of the world |
De Oliveira, RP, Achcar, et al |
Epidemiologic Methods |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper reports a broad study using epidemic-related counting data of COVID-19 disease caused by the novel coronavirus
(SARS-CoV-2). The considered dataset refers to 119 countries' daily counts of reported cases and deaths in a fixed period. For the data analysis, it has been adopted a beta regression model assuming different regions of the world where it was possible to discover
important economic, health and social factors affecting the behavior of the pandemic in different countries. The Bayesian method was applied to fit the proposed model. Some interesting conclusions were obtained in this study, which could be of great interest
to epidemiologists, health authorities, and the general public in the face of the forthcoming hard times of the global pandemic. © 2020 Walter de Gruyter GmbH, Berlin/Boston 2020. |
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del Castillo Pardo de Vera, JL, Cebrián Carretero, et al |
Revista Espanola de Cirugia Oral y Maxilofacial |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
This study will be analyzing the patients’ epidemiological and clinical aspects, surgical technique employed, surgical
time, type of cannula used, postoperative complications and the patients’ clinical monitoring. A total of 22 patients underwent open elective tracheotomy. There were twenty-two males and three females aged between 40 and 77 (mean: 64,9 years-old). In all cases
tracheotomy was carried out due to pulmonary process caused by COVID-19 bilateral pneumonia. Two patients presented pneumothorax in the immediate postoperatory care as a complication, one perished during the procedure and another did so after arriving to the
Intensive Care Unit after the tracheotomy surgery. |
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Delgado, A, Huamaní, et al |
International Journal of Emerging Trends in Engineering Research |
Healthcare Response | Réponse des soins de santé |
Globally, the massive expansion of acute respiratory syndrome (COVID_19) is mainly caused by the massive agglomeration
of people at the time of travel, as a person infected with the virus who does not have the respective preventive measures can infect 3 more people according to studies. For this reason, here is proposed a mobile application with the use of the Machine Learning
methodology for future prediction, through the historical data learned. In this scenario, historical data collection is performed and a decision tree is designed to evaluate the behavior of the data divided into three evaluation criteria (high, medium, and
low) probability. As a result, the design of the App is shown with spaces for patient follow-up through, constant chat (doctor-patient), patient communication forums, prescriptions, recommendations and up-to-date information about the virus. This app will
be useful for all Peruvian citizens as they avoid mass congestion of people when they move to a health center to have a discard test or other frequently asked questions to a doctor. © 2020, World Academy of Research in Science and Engineering. All rights reserved. |
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Desterke, C, Turhan, et al |
iScience |
Clinical data| Données cliniques |
Authors performed transcriptome analyses of lung biopsies from patients with COVID-19, revealing a gene enrichment
pattern similar to that of PPARγ-knockout macrophages. Single-cell gene expression analysis of bronchoalveolar lavage fluids revealed a characteristic trajectory of PPARγ-related disturbance in the CD14+/CD16+ cells. We identified a correlation with the disease
severity and the reduced expression of several members of the PPARγ complex such as EP300, RXRA, RARA, SUMO1, NR3C1, and CCDC88A. ChIP-seq analyses confirmed repression of the PPARγ-RXRA-NR3C1 cistrome in COVID-19 lung samples. |
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SARS-CoV-2 Vertical Transmission: Rare But a Potential Possibility |
Dhawan, S, Pandey, et al |
Indian J Pediatr |
Transmission Clinical data| Données cliniques |
Evidence about vertical transmission in Covid-19 is sparse and rapidly evolving . Authors report one case with probable
intrapartum transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in a neonate with respiratory distress. |
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Response to COVID-19 in South Korea and implications for lifting stringent interventions |
Dighe, A, Cattarino, et al |
BMC Med |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique Public Health response| Interventions de santé publique |
Authors systematically extracted numbers of suspected cases tested, PCR-confirmed cases, deaths, isolated confirmed
cases, and numbers of confirmed cases with an identified epidemiological link from publicly available data. We estimated the time-varying reproduction number, R(t), using an established Bayesian framework, and reviewed the package of interventions implemented
by South Korea using our extracted data, plus published literature and government sources.We estimated that after the initial rapid growth in cases, R(t) dropped below one in early April before increasing to a maximum of 1.94 (95%CrI, 1.64-2.27) in May following
outbreaks in Seoul Metropolitan Region. By mid-June, R(t) was back below one where it remained until the end of our study (July 13th). Despite less stringent "lockdown" measures, strong social distancing measures were implemented in high-incidence areas and
studies measured a considerable national decrease in movement in late February. |
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Modeling evaporation of water droplets as applied to survival of airborne viruses |
Dombrovsky, LA, Fedorets, et al |
Atmosphere |
Epidemiology| Épidémiologie Transmission |
Virological studies indicate that airborne virus survival is very sensitive to air humidity and temperature. We employ
a model of droplet evaporation with the account for the Knudsen layer. This model suggests that evaporation is sensitive to both temperature and the relative humidity (RH) of the ambient air. We also discuss various mechanisms such as the effect of solar irradiation,
the dynamic relaxation of moving droplets in ambient air and the gravitational sedimentation of the droplets. the maximum estimate for the spectral radiative flux in the case of cloudless sky showed that the radiation contribution to evaporation of single
water droplets is insignificant. |
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Durojaye, OA, Mushiana, et al |
Egyptian Journal of Medical Human Genetics |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The resultant cytotoxic effect which is a product of consistent viral replication and proteolytic processing of polyproteins
can be greatly reduced through the inhibition of the viral main proteinase activities. This makes the 3C-like protease of the coronavirus a potential and promising target for therapeutic agents against the viral infection. This study describes the detailed
computational process by which the 2019-nCoV main proteinase coding sequence was mapped out from the viral full genome, translated and the resultant amino acid sequence used in modeling the protein 3D structure. |
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Ekpenyong, Moses, Edoho, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
Whereas accelerated attention beclouded early stages of the coronavirus spread, knowledge of actual pathogenicity and
origin of possible sub-strains remained unclear. By harvesting the Global initiative on Sharing All Influenza Data (GISAID) database (https://www.gisaid.org/), between December 2019 and August 20, 2020, a total of 157 human SARS-CoV-2 (complete) genome sequences
processed by gender, across 6 continents of the world, were analyzed. We hypothesized that data speaks for itself and can discern true and explainable patterns of the disease. Identical genome diversity and pattern correlates analysis performed using a hybrid
of biotechnology and machine learning methods corroborate multiple emergence of SARS-CoV-2 sub-strains and explained the diversity of the SARS-CoV-2. Interestingly, some viral sub-strains progressively transformed into new sub-strain clusters indicating varying
amino acid and strong nucleotide association derived from same origin. A novel approach to cognitive knowledge mining from enriched genome datasets and output targets labeling, helped intelligent prediction of emerging or new viral sub-strains. |
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Elgar, FJ, Stefaniak, et al |
Social Science and Medicine |
Epidemiology| Épidémiologie |
During a 30-day period after recording their tenth death, mortality was positively related to income inequality, trust
and group affiliations and negatively related to social capital from civic engagement and confidence in state institutions. These associations held in bivariate and mutually controlled regression models with controls for population size, age and wealth. The
results indicate that societies that are more economically unequal and lack capacity in some dimensions of social capital experienced more COVID-19 deaths. |
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Elliott, JA, Kenyon, et al |
Br J Surg |
Epidemiology| Épidémiologie Transmission |
This study used a national administrative database to estimate perioperative SARS-CoV-2 infection risk, and associated
mortality, relative to nosocomial transmission rates. The impact of nosocomial transmission was greatest after major emergency surgery, whereas laparoscopic surgery may be protective owing to reduced duration of hospital stay. Procedure-specific risk estimates
are provided to facilitate surgical decision-making and informed consent. Estimated risks. |
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Discourse network of a public issue debate: A study on covid-19 cases in indonesia |
Eriyanto, Ali, DJ |
Jurnal Komunikasi: Malaysian Journal of Communication |
Public Health Priorities| Priorités de santé publique Public Health response| Interventions
de santé publique |
This research is intended to answer the question of the discourses developed in association with Covid-19 management.
Discourse in this regard is understood within the context of public policy, i.e. a set of concepts or ideas conveyed by actors to influence public policies. The research was carried out for five months, starting from 17th November 2019 to 30th April 2020 and
it included 1,123 statements of actors that were published in the media. The results of this study show that a coalition of discourse also occurs in health issues. |
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Faour-Klingbeil, D, Osaili, et al |
Food Control |
Public Health response| Interventions de santé publique |
A total of 1074 subjects from Lebanon, Jordan, and Tunisia were recruited to explore their perception of food and non-food
risks of infection and the influence of the source of information, trust, and attitudes towards the local authorities' communication of risk. Seventy percent of the respondents were concerned that COVID-19 may be transmitted through food. The perception of
risk from touching contaminated surfaces and food packaging and being exposed to infected people during food shopping was even higher. For only less than half of the respondents, the information from local authorities was considered trustworthy and the associated
risk communication and response to false rumors were timely, effective, and clear. |
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Ferrando, StephenJ, Lynch, et al |
SSRN- Lancet prepublication |
Healthcare Response | Réponse des soins de santé |
This report characterizes patients presenting for psychiatric emergencies during the COVID-19 pandemic and describes
COVID-19-related stressors. COVID-19 period children/adolescent patients had more new onset disorders and were more likely to be admitted to inpatient care, but were less likely to present with suicide attempts, impulse control disorders and agitation/aggression.
Adults were more likely to have no access to outpatient care, present with anxiety disorders, and were also more likely to be admitted for inpatient care. COVID-19 directly affected the psychiatric emergency in 25% of patients, with the more severe stressors
triggered by fear of COVID infection (including psychosis), actual COVID infection in self or family members, including death of a loved one. COVID-positive patients were more likely to have psychosis, including new-onset, and were less likely to be depressed/
suicidal compared to their COVID-negative counterparts. |
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Fong, S, Li, et al |
Can J Anaesth |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
Patients with coronavirus disease (COVID-19) are at risk of requiring mechanical ventilation, and concerns of protecting
healthcare workers during aerosol-generating medical procedures has led to the design of the aerosol box. For the normal airway scenario, the mean (SD) time to intubation was 18.6 (3.5) sec for no box and 20.4 (3.3) sec for box (mean difference, 1.8; 95% CI,
0.2 to 3.4). During difficult airway scenarios only, the time to intubation was 34.4 (25.6) sec with the aerosol box and 27.3 (13.2) sec without the aerosol box (mean difference, 7.1; 95% CI, -2.5 to 16.7). |
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Forlano, R, Mullish, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We here describe the clinical characteristics and outcomes of non-alcoholic fatty liver disease (NAFLD) patients in
a cohort hospitalised for COVID-19. The NAFLD cohort (n = 61) was significantly younger (60 vs 70.5 years, p = 0.046) at presentation compared to the non-NAFLD (n = 132). NAFLD diagnosis was not associated with adverse outcomes. However, the NAFLD group had
higher C reactive protein (CRP) (107 vs 91.2 mg/L, p = 0.05) compared to non-NAFLD(n = 132). Among NAFLD patients, male gender (p = 0.01), ferritin (p = 0.003) and EWS (p = 0.047) were associated with in-hospital mortality, while the presence of intermediate/high
risk FIB-4 or liver cirrhosis was not. |
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AICov: An Integrative Deep Learning Framework for COVID-19 Forecasting with Population Covariates |
Fox, GeoffreyC, von Laszewski, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Economics
| Économie |
The COVID-19 pandemic has profound global consequences on health, economic, social, political, and almost every major
aspect of human life. Therefore, it is of great importance to model COVID-19 and other pandemics in terms of the broader social contexts in which they take place. We present the architecture of AICov, which provides an integrative deep learning framework for
COVID-19 forecasting with population covariates, some of which may serve as putative risk factors. We have integrated multiple different strategies into AICov, including the ability to use deep learning strategies based on LSTM and even modeling. To demonstrate
our approach, we have conducted a pilot that integrates population covariates from multiple sources. Thus, AICov not only includes data on COVID-19 cases and deaths but, more importantly, the population's socioeconomic, health and behavioral risk factors at
a local level. The compiled data are fed into AICov, and thus we obtain improved prediction by integration of the data to our model as compared to one that only uses case and death data. |
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Gallaway, MS, Rigler, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
To assess the effect of mitigation strategies in Arizona, the numbers of daily COVID-19 cases and 7-day moving averages
during January 22-August 7, 2020, relative to implementation of enhanced community mitigation measures, were examined. The average number of daily cases increased approximately 151%, from 808 on June 1, 2020 to 2,026 on June 15, 2020 (after stay-at-home order
lifted), necessitating increased preventive measures. On June 17, local officials began implementing and enforcing mask wearing, affecting approximately 85% of the state population. Statewide mitigation measures included limitation of public events; closures
of bars, gyms, movie theaters, and water parks; reduced restaurant dine-in capacity; and voluntary resident action to stay at home and wear masks. The number of COVID-19 cases in Arizona peaked during June 29-July 2, stabilized during July 3-July 12, and further
declined by approximately 75% during July 13-August 7. |
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The English Patient: Evaluating Local Lockdowns Using Real-Time COVID-19 & Consumption Data |
Gathergood, John, Guttman-Kenney, et al |
arXiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
We find UK 'local lockdowns' of cities and sub-regions, focused on limiting contact between households in homes, turn
the tide on rising positive COVID-19 cases without the large declines in consumption accompanying the March 2020 national lockdown, which limited all social contact. Our study harnesses a new source of real-time, transaction-level consumption data that we
show to be highly correlated with official statistics. The effectiveness of local lockdowns are evaluated applying a difference-in-difference approach which exploits nearby localities not subject to local lockdowns as comparison groups. Our findings indicate
that policymakers may be able to contain virus outbreaks without killing local economies. However, the ultimate effectiveness of local lockdowns is expected to be highly dependent on co-ordination between regions and testing. |
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Ghahramani-Asl, R, Porouhan, et al |
Dose-Response |
Clinical data| Données cliniques |
The objective of this study was to assess the feasibility of a treatment planning system in localizing, contouring,
and targeting lung lesions along with an evaluation of volume indices of lung involvement in patients with COVID-19 pneumonia. Authors reported the feasibility of using a treatment planning system in localizing COVID-19 pulmonary lesions and its validity
in the volumetric assessment of infected lung regions. |
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Chilblain-like lesions likely associated with coronavirus disease 2019: A Canadian case presentation |
Glicksman, R, Varner, et al |
Canadian Journal of Emergency Medicine |
Clinical data| Données cliniques |
We describe a case of a patient who presented to the emergency department (ED) with chilblain-like lesions apparently
induced by COVID-19. |
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Psychological distress during the COVID-19 lockdown: The young adults most at risk |
Glowacz, F, Schmits, et al |
Psychiatry research |
Public Health response| Interventions de santé publique |
To control the COVID-19 pandemic, governments have implemented restrictions. This study evaluates psychological distress
related to the crisis and identifies predictive factors of anxiety/depression according to age. 2,871 adults were recruited through an online questionnaire during the lockdown. Three subsamples were identified: 18–30; 30–50; > 50 years. The population suffers
from anxiety and depression. Young adults adu reported lower levels of living space, occupational activity, social contact and alcohol use, but higher anxiety, depression and uncertainty than older participants. This psychological distress can be explained
by lockdown conditions (differently according to age) and by intolerance to uncertainty. Also, youth's alcohol intake has decreased. Deconfinement strategies have been discussed. © 2020 Elsevier B.V. |
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The nutritional and health effects of the COVID-19 pandemic on patients with diabetes mellitus |
Grabia, M, Markiewicz-żukowska, et al |
Nutrients |
Public Health response| Interventions de santé publique |
The aim of the study was to assess the impact of the COVID-19 pandemic on patients with diabetes and their nutrition
and health behaviours. The study demonstrated that the pandemic had a significant impact on the behaviour of patients with diabetes mellitus (DM). |
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Groen, D, A |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We present the VECMA toolkit (VECMAtk), a flexible software environment for single and multiscale simulations that
introduces directly applicable and reusable procedures for verification, validation (V&V), sensitivity analysis (SA) and uncertainty quantification (UQ). It enables users to verify key aspects of their applications, systematically compare and validate the
simulation outputs against observational or benchmark data, and run simulations conveniently on any platform from the desktop to current multi-petascale computers. In this sequel to our paper on VECMAtk which we presented last year, we focus on a range of
functional and performance improvements that we have introduced, cover newly introduced components, and applications examples from seven different domains such as conflict modelling and environmental sciences. We also present several implemented patterns for
UQ/SA and V&V, and guide the reader through one example concerning COVID-19 modelling in detail. |
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Gu, Q, Ouyang, et al |
Journal of X-ray science and technology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to retrospectively analyze and stratify the initial clinical features and chest CT
imaging findings of patients with COVID-19 by gender and age. COVID-19 has various clinical and imaging appearances. However, it has certain characteristics that can be stratified. CT plays an important role in disease diagnosis and early intervention. |
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Guan, Xiaonan, Zhang, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
This study was conducted to assess the therapeutic outcomes of percutaneous coronary intervention (PCI) performed under
the safety measures and normal conditions. The analysis showed that safety measures undertaken in this hospital, including screening of COVID-19 infection and use of personal protection equipment for conducting PCI did not compromise the surgical outcome as
compared with PCI under normal condition, although there were slight increases in incidence of malignant arrhythmia and Takotsubo Syndrome. |
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Guillén, L, Padilla, et al |
Sci Rep |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Authors evaluated early-given tocilizumab in patients hospitalized with COVID-19, and identified outcome predictors.
Preemptive therapy with tocilizumab was safe and associated with favorable outcomes in most patients. |
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Guintivano, Jerry, Dick, et al |
bioRxiv |
Public Health response| Interventions de santé publique |
Between April 20, 2020 and June 19, 2020 authors conducted a survey of the membership of the Psychiatric Genomics Consortium
(PGC) to explore the impact of COVID-19 on their research and academic careers. They provide recommendations for institutions, organizations such as the PGC, as well as individual senior investigators to ensure that the futures of early career investigators,
especially those underrepresented in academic medicine such as women and underrepresented minorities, are not disproportionately disadvantaged by the COVID-19 pandemic. |
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Guo, H, Li, et al |
PLoS One |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
The objective of this study was to evaluate the microbial loading in aerosols produced after air-puff by non-contact
tonometer (NCT) as well as the effect of alcohol disinfection on the inhibition of microbes and thus to provide suggestions for the prevention and control of COVID-19 in ophthalmic departments of hospitals or clinics during the great pandemics. Aerosols containing
microbes were produced by NCT air-puff in the ophthalmic consultation room, which may be a possible virus transmission route in the department of ophthalmology during the COVID-19 pandemic. |
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Xuebijing injection in the treatment of COVID-19: A retrospective case-control study |
Guo, H, Zheng, et al |
Annals of Palliative Medicine |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study aimed to investigate the effect of XBJ on coronavirus disease 2019 (COVID-19) and its effects on IL-6 and
tumor necrosis alpha TNF-α. The results of this study suggest that routine treatment combined with XBJ can better improve the clinical outcomes of COVID-19 patients. |
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Guo, L, Bai, et al |
Zhejiang da xue xue bao.Yi xue ban = Journal of Zhejiang University.Medical sciences |
Public Health response| Interventions de santé publique |
The objective of this study was to investigate the psychological and behavior status of minor children of medical staff
in Hubei province during the coronavirus disease 2019 (COVID-19) epidemic. During COVID-19 epidemic period, the psychological and behavior status of minor children of Hubei medical staff with different ages shows differences with those without parents as medical
staff, particularly in 6-<10 years and 10 to 16 year groups. |
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Guo, Z, Sun, et al |
Journal of cardiothoracic and vascular anesthesia |
Clinical data| Données cliniques |
The objective of this study was to explore special coagulation characteristics and anticoagulation management in extracorporeal
membrane oxygenation (ECMO)–assisted patients with coronavirus disease 2019 (COVID-19). Hypercoagulability and secondary hyperfibrinolysis during ECMO support in COVID-19 patients are common and possibly increase the propensity for thrombotic events and failure
of the oxygenator. |
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Hamidi, S, Zandiatashbar, et al |
Landscape and Urban Planning |
Public health interventions*| Interventions de santé publique |
This longitudinal study employs a natural experimental research design to investigative the impacts of compact development
on reduction in travel to three types of destinations representing a range of essential and non-essential trips in 771 metropolitan counties in the U.S during the shelter-in-place order amid the COVID-19 pandemic. Residents of compact areas have significantly
higher reduction in trips to essential destinations such as grocery stores/pharmacies, and transit stations. |
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Hasell, J, Mathieu, et al |
Sci Data |
Epidemiology| Épidémiologie |
Our understanding of the evolution of the COVID-19 pandemic is built upon data concerning confirmed cases and deaths.
This data, however, can only be meaningfully interpreted alongside an accurate understanding of the extent of virus testing in different countries. This new database brings together official data on the extent of PCR testing over time for 94 countries. We
provide a time series for the daily number of tests performed, or people tested, together with metadata describing data quality and comparability issues needed for the interpretation of the time series. The database is updated regularly through a combination
of automated scraping and manual collection and verification, and is entirely replicable, with sources provided for each observation. In providing accessible cross-country data on testing output, it aims to facilitate the incorporation of this crucial information
into epidemiological studies, as well as track a key component of countries' responses to COVID-19. |
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Haston, JC, Miller, et al |
MMWR Morb Mortal Wkly Rep |
Public Health response| Interventions de santé publique |
For this study, survey data from October 2019 and June 2020 were compared to assess changes in adults' remembering
to wash their hands in six situations. Men, young adults aged 18-24 years, and non-Hispanic White (White) adults were less likely to remember to wash hands in multiple situations. |
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Hendarwan, H, Syachroni, et al |
WHO South-East Asia journal of public health |
Healthcare Response | Réponse des soins de santé |
This paper reports our experiences in rapidly assessing Indonesia's COVID-19 laboratory testing capacity in the early
phase of the pandemic response. Through a questionnaire-based survey carried out between 23 March and 2 April, we estimated the daily tests that could be done by the 44 facilities, excluding the national referral laboratory, first assigned to be COVID-19 diagnostic
laboratories. The capacity constraints were lack of reagents and equipment, and limited human resources; because of these constraints, most of the laboratories were not yet operational. A major hindrance was reliance on imported supplies and the associated
procurement time. Expanding real-time polymerase chain reaction testing capacity, through increased numbers of laboratories and optimization of existing facilities, was clearly the main priority. We also assessed the potential yield from using rapid molecular
testing machines in the country's referral hospitals. |
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Hernandez, A, Muñoz, et al |
Frontiers in Public Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The first patient infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Panama was reported on
March 9, 2020. Here, we describe the first case of recovery from coronavirus disease 2019 (COVID-19) in the country. The patient was a 49-year-old male high school teacher, who did not show any primary symptoms of COVID-19 described by health authorities as
the signs for medical attention. Nonetheless, he became severely ill over the course of 2 weeks and almost lost the battle against COVID-19. The identification of the first cluster of SARS-CoV-2 community transmission in the secondary school where the patient
of this case report taught, led to the closure of the school and, a day after, the shutdown of the national education system, which may have prevented the spread and slowed the transmission rate of COVID-19 during the early stages of invasion. This case report
highlights the need to increase awareness among healthcare professionals in Latin America to consider symptoms such as anosmia and dysgeusia as the sentinel signs of COVID-19 infection in order to prevent deaths, especially in high-risk patients. © Copyright
© 2020 Hernandez, Muñoz, Rojas, Eskildsen, Sandoval, Rao, Gittens and Loaiza. |
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Hoenig, K, Wenz, et al |
European Societies |
Public Health response| Interventions de santé publique |
We examine how different educational groups reacted to the beginning of the COVID-19 pandemic in Germany by looking
at health-related behavior–social distancing, increased hygiene, and mask wearing–as well as changes in working conditions–work from home, reduced working hours, and not working–as a structural indicator that can mitigate the risk of infection. More than three
quarters of respondents in all educational groups complied with recommended social distancing and hand hygiene behaviors, and differences by education did not exceed ten percentage points. Regarding working conditions, highly educated respondents had a likelihood
of over 45 percent to work from home during the pandemic. This number decreased to 17 and 11 percent for those with intermediate and low levels of education, respectively. It seems that education-based inequalities in the risk of infection with COVID-19 do
not primarily stem from differences in health behavior but rather from structural causes, that is, inability to practice social distancing at work. |
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Psychological well-being of Australian hospital clinical staff during the COVID-19 pandemic |
Holton, S, Wynter, et al |
Aust Health Rev |
Healthcare Response | Réponse des soins de santé |
This study assessed the psychological well-being of Australian hospital clinical staff during the COVID-19 pandemic.
In all, 668 people responded to the survey (nurses/midwives, n=391; doctors, n=138; AH staff, n=139). Of these, 108 (16.2%) had direct contact with people with a COVID-19 diagnosis. Approximately one-quarter of respondents reported symptoms of psychological
distress. Between 11% (AH staff) and 29% (nurses/midwives) had anxiety scores in the mild to extremely severe ranges. Nurses and midwives had significantly higher anxiety scores than doctors (P<0.001) and AH staff (P<0.001). Direct contact with people with
a COVID-19 diagnosis (P<0.001) and being a nurse or midwife (P<0.001) were associated with higher anxiety scores. Higher ratings of the health service's pandemic response and staff support strategies were protective against depression (P<0.001), anxiety (P<0.05)
and stress (P<0.001). |
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Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19 |
Horby, P, Mafham, et al |
N Engl J Med |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
In this randomized, controlled, open-label platform trial comparing a range of possible treatments with usual care
in patients hospitalized with Covid-19, we randomly assigned 1561 patients to receive hydroxychloroquine and 3155 to receive usual care. The primary outcome was 28-day mortality. Among patients hospitalized with Covid-19, those who received hydroxychloroquine
did not have a lower incidence of death at 28 days than those who received usual care. |
|
Horii, T, Fujioka, et al |
Radiol Case Rep |
Clinical data| Données cliniques |
We report the case of a 66-year-old man with underlying hypertension and a history of smoking 76 packs a year; he was
frequently monitored by computed tomography for pulmonary changes during the period from early symptom onset to death. Furthermore, he developed a pneumothorax during the course. The occurrence of pneumothorax in COVID-19 patients is not common, and there
have been only a few previous reports. This is a valuable case of pneumothorax in a patient with COVID-19 treated with a ventilator and extracorporeal membrane oxygenation. |
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Treatment of Anosmia and Ageusia in COVID-19 Patients by Using Coffee |
Hosseini, Asiyeh, Mirmehdi, et al |
Research Square prepub |
Clinical data| Données cliniques |
This study aims to examine influence of coffee on smell and taste of patients with Covid-19. In order to investigate
the effect of coffee consumption on the taste and smell of COVID-19 patients, we attempted to sample in 20 provinces of the country, COVID-19 patients were separated by gender and underlying and non-underlying disease, doses of 15-20 mg for non-underlying
patients and 25-30 mg for underlying patients. The reason for determining this amount of coffee is that every coffee we want to prepare needs a scoop of 14 grams of coffee, which we determine. For some people, it was determine 14 grams and for some people
28 grams of coffee was determined due to consumed in two cups of coffee. Patients with Covid-19 had reversibility on the first and second day. It was clear that there is a small gap between the proportion of recovered patients in the underlying and non-underlying
patients, but due to the high volume of observations, this small difference is evident. Anosmia and Ageusia is more prevalent in COVID-19 patients. Caffeine in coffee reduced the reversibility of the sense of smell and taste of people with Covid-19. It was
concluded that the chances of recovery are higher for those who do not have the underlying disease than for the other groups and for those who suffer from all three types of the underlying disease than for the other groups. |
|
Hu, J, He, et al |
J Appl Psychol |
Public Health response| Interventions de santé publique |
Coronavirus disease 2019 (COVID-19) is a disruptive event devastating to the workplace and the global community. Drawing
on terror management theory, we develop and test a model that explains how COVID-19-triggered mortality salience influences employees' state anxiety and their responses at and outside work. We conducted an experience sampling method study using employees from
an information technology firm in China when COVID-19 was surging there and two experiments using employees from a variety of industries in the United States when it became a new epicenter of the global outbreak. Results from 3 studies largely supported our
theoretical hypotheses. Specifically, our research showed that mortality salience concerning COVID-19 was positively related to employees' state anxiety (general anxiety in Study 1 and Study 2 and death-specific anxiety in Study 3). Our studies also found
that servant leadership is particularly crucial in guiding employees with state anxiety associated with COVID-19 mortality salience to be engaged in their jobs and to contribute more to the broader community. Our findings offer timely, valuable implications
for theory and practice. (PsycInfo Database Record (c) 2020 APA, all rights reserved). |
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|
Huang, Y, Guo, et al |
Diabetes research and clinical practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to clarify the associations between fasting plasma glucose levels and mortality of COVID-19 in patients without
diabetes. Compared with survivors, non-survivors were more likely to have underlying medical conditions including hypertension and chronic pulmonary diseases. Non-survivors had higher C-reactive protein (CRP), procalcitonin (PCT), interleukin (IL)-2R, IL-6,
IL-8 and, tumor necrosis factor-α (TNF-α) levels, while lower lymphocyte counts as compared with those of survivors (all P<0.05). Besides, patients with higher fasting plasma glucose (FPG) had higher IL-6, IL-8, CRP levels and mortality; while lower lymphocyte
counts. After adjusting for age and gender, each tertile increment of FPG levels conferred 3.54-fold higher risks of death (odds ratio, 3.54; 95% confidential interval, 1.25-10.06, P=0.018). |
|
|
32985160; Early differential diagnosis between COVID-19 and mycoplasma pneumonia with
chest CT scan |
Huo, X, Xue, et al |
Zhejiang da xue xue bao.Yi xue ban = Journal of Zhejiang University.Medical sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
OBJECTIVE: To early differentiate between coronavirus disease 2019 (COVID-19) and adult mycoplasma pneumonia with chest
CT scan. METHODS: Twenty-six patients with COVID-19 and 21 patients with adult mycoplasma pneumonia confirmed with RT-PCR test were enrolled from Zibo First Hospital and Lanshan People's Hospital during December 1st 2019 and March 14th 2020. The early chest
CT manifestations were analyzed and compared between the two groups. RESULTS: The interstitial changes with ground glass density shadow (GGO) were similar in two groups during first chest CT examination (P>0.05). There were more lung lobes involved on the
first chest CT in COVID-19 patients, which were mostly distributed in the dorsal outer zone (23/26, 88.5%), and nearly half of them (12/26, 46.2%) were accompanied by crazy-paving sign; while the lesions in adult mycoplasma pneumonia patients were mostly distributed
along the bronchi, and the bronchial wall was thickened (19/21, 90.5%), accompanied with tree buds / fog signs (19/21, 90.5%). The above CT signs were significantly different between the two kinds of pneumonia (all P<0.01). COVID-19 had a longer course compared
with mycoplasma pneumonia, the disease peaks of COVID-19 patients was on day (10.5±3.8), while the disease on CT was almost absorbed on day (7.9±2.2) in adult mycoplasma pneumonia. The length of hospital stay in COVID-19 patients was significantly longer than
that of mycoplasma pneumonia patients (19.5±4.3) d vs (7.9±2.2) d, P<0.01]. CONCLUSIONS: The lesions of adult mycoplasma pneumonia are mostly distributed along the bronchi with tree buds/fog signs, while the lesions of COVID-19 are mainly distributed in the
dorsal outer zone accompanied by crazy-paving sign, which can early distinguish two diseases. |
|
Gaining back what is lost: recovering the sense of smell in mild to moderate patients after COVID-19 |
Iannuzzi, L, Salzo, et al |
Chem Senses |
Clinical data| Données cliniques |
The purpose of our cohort study was to quantify olfactory deficits in COVID-19 patients using Sniffin' Sticks and a
pre-post design to evaluate olfactory recovery. 30 adult patients with laboratory-confirmed mild to moderate forms of COVID-19 underwent a quantitative olfactory test performed with the Sniffin' Sticks Test (SST, Burghardt®, Wedel, Germany) considering olfactory
threshold (T), odor discrimination (D) and odor identification (I). Results were presented as a composite TDI score (range 1-48) used to define functional anosmia (TDI ≤ 16.5), hyposmia (16.5 <TDI< 30.5) or functionally normal ability to smell (TDI ≥ 30.5).
Patients also self-evaluated their olfactory function by rating their ability to smell on a visual analogue scale (VAS rating) and answering a validated Italian questionnaire (Hyposmia Rating Scale-HRS). Patients were tested during hospitalization and about
two months after symptoms onset. During the hospitalization the overall TDI score indicated that our cohort had impairments in their olfactory ability (10 % was diagnosed with Anosmia and more than 50 % were hyposmic). Almost all patients showed a significant
improvement at around one month following the first test and for all the parts of the SST except for odor identification. None of the subjects at one month was still diagnosed with Anosmia. We also quantified the improvement in the TDI score based on initial
diagnosis. Anosmic subjects showed a greater improvement than hyposmic and normosmic subjects. In conclusion, within a month time window and two months after symptoms' onset, in our cohort of patients we observed a substantial improvement in the olfactory
abilities. |
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Global
attitudes in the management of acute appendicitis during COVID-19 pandemic: ACIE Appy Study |
Ielpo, B, Podda, et al |
Br J Surg |
Healthcare Response | Réponse des soins de santé |
The Association of Italian Surgeons in Europe designed an online survey to assess the current attitude of surgeons
globally regarding the management of patients with acute appendicitis during the pandemic. Of 744 answers, 709 (from 66 countries) were complete and were included in the analysis. Most hospitals were treating both patients with and those without COVID. There
was variation in screening indications and modality used, with chest X-ray plus molecular testing (PCR) being the commonest (19·8 per cent). Conservative management of complicated and uncomplicated appendicitis was used by 6·6 and 2·4 per cent respectively
before, but 23·7 and 5·3 per cent, during the pandemic (both P < 0·001). One-third changed their approach from laparoscopic to open surgery owing to the popular (but evidence-lacking) advice from expert groups during the initial phase of the pandemic. No agreement
on how to filter surgical smoke plume during laparoscopy was identified. There was an overall reduction in the number of patients admitted with appendicitis and one-third felt that patients who did present had more severe appendicitis than they usually observe. |
|
Forecasting with Importance-Sampling and Path-Integrals: Applications to COVID-19 |
Ingber, Lester |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Background: Forecasting nonlinear stochastic systems most often is quite difficult, without giving in to temptations
to simply simplify models for the sake of permitting simple computations. Objective: Here, two basic algorithms, Adaptive Simulated Annealing (ASA) and path-integral codes PATHINT/PATHTREE (and their quantum generalizations qPATHINT/qPATHTREE) are described
as being useful to detail such systems. Method: ASA and PATHINT/PATHTREE have been demonstrated as being effective to forecast properties in three disparate disciplines in neuroscience, financial markets, and combat analysis. Applications are described for
COVID-19. Results: Not only can selected systems in these three disciplines be aptly modeled, but results of detailed calculations have led to new results and insights not previously obtained. Conclusion: While optimization and path-integral algorithms are
now quite well-known (at least to many scientists), these applications give strong support to a quite generic application of these tools to stochastic nonlinear systems. |
|
Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens
in COVID-19 patients |
Isho, B, Abe, et al |
Sci Immunol |
Clinical data| Données cliniques Immunology | Immunologie |
While the antibody response to SARS-CoV-2 has been extensively studied in blood, relatively little is known about the
antibody response in saliva and its relationship to systemic antibody levels. Here, we profiled by enzyme-linked immunosorbent assays (ELISAs) IgG, IgA and IgM responses to the SARS-CoV-2 spike protein (full length trimer) and its receptor-binding domain (RBD)
in serum and saliva of acute and convalescent patients with laboratory-diagnosed COVID-19 ranging from 3-115 days post-symptom onset (PSO), compared to negative controls. Anti-SARS-CoV-2 antibody responses were readily detected in serum and saliva, with peak
IgG levels attained by 16-30 days PSO. Longitudinal analysis revealed that anti-SARS-CoV-2 IgA and IgM antibodies rapidly decayed, while IgG antibodies remained relatively stable up to 105 days PSO in both biofluids. Lastly, IgG, IgM and to a lesser extent
IgA responses to spike and RBD in the serum positively correlated with matched saliva samples. This study confirms that serum and saliva IgG antibodies to SARS-CoV-2 are maintained in the majority of COVID-19 patients for at least 3 months PSO. IgG responses
in saliva may serve as a surrogate measure of systemic immunity to SARS-CoV-2 based on their correlation with serum IgG responses. |
|
Iyer, AS, Jones, et al |
Sci Immunol |
Clinical data| Données cliniques Immunology | Immunologie |
We measured plasma and/or serum antibody responses to the receptor-binding domain (RBD) of the spike (S) protein of
SARS-CoV-2 in 343 North American patients infected with SARS-CoV-2 (of which 93% required hospitalization) up to 122 days after symptom onset and compared them to responses in 1548 individuals whose blood samples were obtained prior to the pandemic. After
setting seropositivity thresholds for perfect specificity (100%), we estimated sensitivities of 95% for IgG, 90% for IgA, and 81% for IgM for detecting infected individuals between 15 and 28 days after symptom onset. While the median time to seroconversion
was nearly 12 days across all three isotypes tested, IgA and IgM antibodies against RBD were short-lived with median times to seroreversion of 71 and 49 days after symptom onset. In contrast, anti-RBD IgG responses decayed slowly through 90 days with only
3 seropositive individuals seroreverting within this time period. IgG antibodies to SARS-CoV-2 RBD were strongly correlated with anti-S neutralizing antibody titers, which demonstrated little to no decrease over 75 days since symptom onset. We observed no
cross-reactivity of the SARS-CoV-2 RBD-targeted antibodies with other widely circulating coronaviruses (HKU1, 229 E, OC43, NL63). These data suggest that RBD-targeted antibodies are excellent markers of previous and recent infection, that differential isotype
measurements can help distinguish between recent and older infections, and that IgG responses persist over the first few months after infection and are highly correlated with neutralizing antibodies. |
|
|
Jeppesen, SS, Bentsen, et al |
Acta Oncol |
Healthcare Response | Réponse des soins de santé |
The aim of this cross-sectional study was to investigate quality of life (QoL) for patients with cancer during the
COVID-19 pandemic. In total, 9% of patients with cancer had refrained from consulting a doctor or the hospital due to fear of COVID-19 infection, and 80% were concerned about contracting COVID-19 to some extent. Seventeen patients were tested positive for
COVID-19. The mean global QoL and emotional functioning (EF) scores were 71.3 and 82.8, respectively. In comparison to the 'Barometer Study', no clinical significant differences in QoL and EF scores were observed. Multivariate analysis demonstrated that being
'Concerned about contracting corona-virus' was correlated with lower QoL and EF scores. Factors associated with being concerned of contracting COVID-19 were comorbid conditions, incurable cancer, receiving medical cancer treatment and female gender. |
|
|
Ji, M, Xia, et al |
RSC Advances |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We developed a microfluidic disc-direct RT-qPCR (dirRT-qPCR) assay for rapid multiplex detection of SARS-CoV-2, influenza
A and B viral infection in pharyngeal swab samples in an automated manner. Choices of the DNA polymerase, concentrations of dTPs and MgCl2were characterized to optimize the assay. A detection limit of 2 × 101copies per reaction was found in all three viral
RNAs with as little as 2 μL of swab samples. The accuracy of our assay was evaluated with 2127 clinical swab samples of infection with these three viruses and healthy controls, and it possessed a consistency rate of 100, 99.54 and 99.25% in SARS-CoV-2, influenza
A and B detection in comparison to standard RT-qPCR. The reported scheme of our assay is capable of screening other viral infections for up to 16 targets simultaneously. The whole diagnosis could be completed in 1.5 hours after simple sample loading by a non-technical
expert. This constitutes an enabling strategy for large-scale point-of-care screening of multiple viral infections, which ultimately lead to a pathway for resolving the critical issue of early diagnosis for the prevention and control of viral outbreaks. |
|
|
John, S, Hussain, et al |
Clinical neurology and neurosurgery |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to compare ischemic and hemorrhagic stroke patients with COVID-19 to non-COVID-19 controls, and to
describe changes in stroke admission patterns during the pandemic. There was a 41.9% increase in stroke admissions in 2020 (148 vs 210,P = .001). Stroke continues to occur during this pandemic and stroke pathways have been affected by the pandemic. Stroke
occurs in approximately 5% of patients with COVID-19. COVID-19 associated ischemic stroke occurs in predominantly male patients who are younger, with fewer vascular risk factors, can be more severe, and have higher rates of LVO. Despite an increase in LVO
during the pandemic, treatment with mechanical thrombectomy has not increased. COVID-19 associated hemorrhagic stroke does not differ from non-COVID-19 hemorrhagic stroke patients. |
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A CPU-FPGA heterogeneous approach for biological sequence comparison using high-level synthesis |
Jorge, CAC, Nery, et al |
Concurrency Computation |
Coronavirology| Coronavirologie |
This article presents a high-level synthesis implementation of the longest common subsequence (LCS) algorithm combined
with a weighted-based scheduler for comparing biological sequences prioritizing energy consumption or execution time. The LCS algorithm has been thoroughly tailored using Vivado High-Level Synthesis tool, which is able to synthesize register transfer level
(RTL) from high-level language descriptions, such as C/C++. Performance and energy consumption results were obtained with a CPU Intel Core i7-3770 CPU and an Alpha-Data ADM-PCIE-KU3 board that has a Xilinx Kintex UltraScale XCKU060 FPGA chip. We executed a
batch of 20 comparisons of sequences on 10k, 20k, and 50k sizes. Our experiments showed that the energy consumption on the combined approach was significantly lower when compared to the CPU, achieving 75% energy reduction on 50k comparisons. We also used the
tool proposed in this article to do a case study on Covid-19, with real SARS-CoV-2 sequences, comparing their LCS scores. © 2020 John Wiley & Sons Ltd |
|
Kabarriti, R, Brodin, et al |
JAMA network open |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
This study aimed to investigate whether presenting comorbidities in patients with COVID-19 in New York City differed
by race/ethnicity and whether case fatality rates varied among different ethnic and racial groups, controlling for presenting comorbidities and other risk factors. Of 9268 patients who were tested, 5902 ethnically diverse patients (63.7%) had SARS-CoV-2. Of
these, 3129 patients (53.0%) were women, and the median (interquartile range) age was 58 (44-71) years. A total of 918 patients (15.5%) died within the study time frame. Overall, 1905 patients (32.3%) identified as Hispanic; 1935 (32.8%), non-Hispanic Black;
509 (8.6%), non-Hispanic White; and 171 (2.9%), Asian; the death rates were 16.2% (309), 17.2% (333), 20.0% (102), and 17.0% (29), respectively (P = .25). Hispanic and non-Hispanic Black patients had a higher proportion of more than 2 medical comorbidities
with 654 (34.3%) and 764 (39.5%), respectively, compared with 147 (28.9%) among non-Hispanic White patients (P < .001). Hispanic and non-Hispanic Black patients were also more likely to test positive for COVID-19 than White patients, with 1905 of 2919 Hispanic
patients (65.3%), 1935 of 2823 non-Hispanic Black patients (68.5%), and 509 of 960 non-Hispanic White patients (53.0%) having positive test results for SARS-CoV-2 (P < .001). While controlling for age, sex, socioeconomic status and comorbidities, patients
identifying as Hispanic (hazard ratio, 0.77; 95% CI, 0.61-0.98; P = .03) or non-Hispanic Black (hazard ratio, 0.69; 95% CI, 0.55-0.87; P = .002) had slightly improved survival compared with non-Hispanic White patients. |
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That Woman from Michigan: How Gender Resentment Shapes the Efficacy of Stay-at-Home Policies |
Kalaf-Hughes, N, Leiter, et al |
Politics and Gender |
Public Health response| Interventions de santé publique |
The United States has the highest number of COVID-19 cases, yet many Americans have responded indifferently towards
policies designed to combat the spread of the virus. While nearly all 50 states have implemented some type of stay-at-home policy to encourage social distancing, there has been high variation in the degree of compliance. We argue this variance is in part driven
by gender resentment. Gender resentment reduces trust in female political leaders, and thus decreases compliance with government policy and recommendations. Using data from SafeGraph and the 2016 American National Election Study, we demonstrate the effect
of stay-at-home policies on social distancing is reduced when gender resentment increases in states with female leaders. However, when gender resentment is low, there is no difference in the effect of policies on behavior. This research has important implications
for understanding unseen barriers that can mediate the efficacy of female political leaders. © 2020 BMJ Publishing Group. All rights reserved. |
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Graduate employability post-COVID-19: the case of a Malaysian public university |
Kamaruddin, MIH, Ahmad, et al |
Higher Education, Skills and Work-based Learning |
Public Health response| Interventions de santé publique |
This study presents an effort to identify and understand the impact of the coronavirus disease 2019 (COVID-19) pandemic
on the graduate employability (GE) of Universiti Sains Islam Malaysia (USIM) final year students. The findings reveal that USIM final year students are ready to perform their internship even during the lockdown period. Meanwhile, for the employment prospects
in the future, results show that they believed that the employment prospects in the future after COVID-19 is low. |
|
The impact of COVID-19 pandemic on patients with ANCA associated vasculitis |
Kant, S, Morris, et al |
J Nephrol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to investigate the incidence and impact of COVID-19 in patients with ANCA-associated vasculitis (AAV) via
a telephone questionnaire-based patient survey and chart review. The incidence of COVID-19 in patients with AAV appears to be similar to that of the general population. Rituximab maintenance was postponed in 21 patients and twelve patients experienced disease
relapse. |
|
Kared, Hassen, Redd, et al |
bioRxiv |
Coronavirology| Coronavirologie Immunology | Immunologie |
In this study our multiplexed peptide-MHC tetramer approach sought to identify epitopes recognized by CD8+ T cells
that span different viral proteins in COVID-19 convalescent subjects and reveal the unmanipulated phenotypic profiles of these cells. 132 distinct SARS-CoV-2-specific CD8+ T cell epitope responses across six different HLAs were detected, corresponding to 52
unique reactivities. T cell responses were directed against several structural and non-structural virus proteins. Modelling demonstrated a coordinated and dynamic immune response characterized by a decrease in inflammation, increase in neutralizing antibody
titer, and differentiation of a specific CD8+ T cell response. |
|
|
Khaled, A, Siddiqua, et al |
Risk Management and Healthcare Policy |
Public Health response| Interventions de santé publique |
This descriptive cross-sectional study aims to evaluate the knowledge and attitude of the community from the Aseer
Region, Saudi Arabia, toward COVID-19 and their precautionary measures against the disease. Altogether, 740 participants completed the online questionnaire. The mean knowledge score concerning COVID-19 was 8.08 ± 1.765. The mean attitude score regarding COVID-19
was 9.74 ± 1.935, whereas the mean precautionary measures score was 10.09 ± 1.91. |
|
|
Khan, S, Asif, et al |
J Racial Ethn Health Disparities |
Public Health response| Interventions de santé publique |
The objective of this study was to investigate the readability and presence of translated online information readily
available to the British public during COVID-19. The median scores of the pooled data (n = 148) had shown that the majority of websites were unreadable to the average British reader according to each of the five readability calculations used. Only 3.4% and
6.8% of the pooled websites had readily available translated material and accompanying graphic material, respectively. |
|
|
IoMT-based smart monitoring hierarchical fuzzy inference system for diagnosis of covid-19 |
Khan, TA, Abbas, et al |
Computers, Materials and Continua |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
To deal with the prediction and diagnosis of COVID-19, we propose an Internet of Medical Things-based Smart Monitoring
Hierarchical Mamdani Fuzzy Inference System (IoMTSM-HMFIS). The proposed system determines the various factors like fever, cough, complete blood count, respiratory rate, Ct-chest, Erythrocyte sedimentation rate and C-reactive protein, family history, and antibody
detection (lgG) that are directly involved in COVID-19. Overall the COVID-19 IoMTSM-HMFIS system has an overall accuracy of approximately 83%. |
|
Khanal, N, Singh, et al |
Kathmandu University Medical Journal |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to assess the Knowledge, Attitudes and Practices (KAP) of dental practitioners regarding
the Coronavirus Disease 2019 (COVID-2019) pandemic. The total number of the responses received (860) was divided with regard to various continents (Asia, Americas - North and South, Europe, Africa, and other - Australia and Antarctica). High/Good knowledge
and practice scores were observed among 92.7% and 79.5 % of the dentists, respectively. Good knowledge scores were significantly associated with qualifications (p = 0.04) and years of practice (p = 0.02); good practice scores were associated with qualifications
only (p = 0.03). |
|
|
Machine learning based approaches for detecting COVID-19 using clinical text data |
Khanday, AMUD, Rabani, et al |
International Journal of Information Technology (Singapore) |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper, we classified textual clinical reports into four classes by using classical and ensemble machine learning
algorithms. Feature engineering was performed using techniques like Term frequency/inverse document frequency (TF/IDF), Bag of words (BOW) and report length. These features were supplied to traditional and ensemble machine learning classifiers. Logistic regression
and Multinomial Naïve Bayes showed better results than other ML algorithms by having 96.2% testing accuracy. |
|
Foreign investors' abnormal trading behavior in the time of COVID-19 |
Khanthavit, A |
Journal of Asian Finance, Economics and Business |
Economics | Économie |
This study investigates the behavior of foreign investors in the Stock Exchange of Thailand (SET) in the time of coronavirus
disease 2019 (COVID-19) as to whether trading is abnormal, what strategy is followed, whether herd behavior is present, and whether the actions destabilize the market. The results show that foreign investors’ abnormal trading volume is negative and significant.
An analysis of the abnormal trading volume with stock returns reveals that foreign investors are not positive-feedback investors, but rather, they self-herd. Although foreign investors’ abnormal trading does not destabilize the market, it induces stock-return
volatility of a similar size to normal trade. |
|
Kharma, MY, Koussa, et al |
Eur J Dent |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to evaluate the sources of anxiety and stress among dental students in Saudi Arabia when returning
back to training in dental colleges in the era of COVID-19, with the evaluation of a secure condition for training and practicing without the risk of contamination. There were 315 respondents who participated in the study. About 85% participants feel anxiety
and stress to return to the dental college. Almost 75% had supported the procedures to be implemented to ensure the safety of the students. About 43% of respondents agreed to continue e-learning in theoretical part only, 1% for clinical part only, and 47%
in both. Finally, 67% of respondents preferred the use of alternative methods of learning (Phantom Laboratory) or any simulated teaching aids. |
|
|
Behavioral changes in patients with diabetes during the COVID-19 pandemic |
Kishimoto, M, Ishikawa, et al |
Diabetology International |
Public Health response| Interventions de santé publique |
We investigated the pandemic emergency situation’s effect on Japanese diabetes patients’ lifestyle and glycemic control.
Results indicate that during the state of emergency period, decreased physical activity levels negatively affected glycemic control. Additionally, diabetes patients are likely to shift to teleworking and stay home for longer periods. |
|
Kokoszka-Bargieł, I, Cyprys, et al |
Medical Science Monitor |
Clinical data| Données cliniques |
The primary objective of this study was to analyze patients admitted to the ICU in a multidisciplinary hospital located
in the Silesian region of Poland. The secondary purpose was to analyze the patients who were referred but ultimately ineligible for ICU admission during the same time period because their ICU treatment was regarded as medically or ethically inappropriate.
Results indicate that patients with COVID-19 requiring ICU admission in our studied population were frail and had significant comorbidities. The outcomes in this group were poor and did not seem to be influenced by ICU admission. |
|
|
Kulp, Christopher |
SSRN- Lancet prepublication |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this paper, an agent-based model is presented which simulates the spread of a disease which starts with one infected
agent in a simulated college campus. The agents in the model are randomly selected to follow social distancing and/or mask-wearing guidelines. A variety of compliance strategies are considered, including constant compliance, a time-based compliance where every
agent complies during business hours and a subset does not during evenings and weekends, and a model where the population density is increased on weekends, with the introduced agents not complying with the guidelines. The model indicates that the more agents
who comply after hours, the better the chances of restricting the outbreak to the originally infected agent as well as suggests that small weekend gatherings need not significantly contribute to the total number of infections on campus. |
|
|
Kumar, A, Pandey, et al |
Zoo Biol |
Coronavirology| Coronavirologie zoonoses |
The article is presenting a bioinformatics based method predicting susceptibility for SARS-CoV-2 infection in domestic
and wildlife animals. Recently, there were reports of cats and ferrets, dogs, minks, golden hamster, rhesus monkeys, tigers, and lions testing for SARS-CoV-2 RNA which indicated for the possible interspecies viral transmission. Our method successfully predicted
the susceptibility of these animals for contracting SARS-CoV-2 infection. This method can be used as a screening tool for guiding viral RNA testing for domestic and wildlife animals at risk of getting COVID-19. We provide a list of the animals at risk of developing
COVID-19 based on the susceptibility score. |
|
|
Kumar, A, Saxena, et al |
SpringerBriefs in Applied Sciences and Technology |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
The aim of this study is to determine the mutation(s) in the sequence of the spike protein, which plays a significant
role in transmission from human to human. By using bioinformatics approach first we analyzed spike protein sequence of four nearest coronavirus family that include COVID-19, bat coronavirus RaTG13, pangolian coronavirus and SARS CoV, to determine phylogenetic
distance between them. The homology modeling of COVID-19 spike protein has been done by iTASSER. and the protein-protein docking with human receptor ACE2 by Frodock web based docking tool showing the less binding energy of COVID-19 (−12.7 kcal/mol) in comparison
with SARS CoV (10.3 kcal/mol). |
|
|
Lam, Shao Wei Sean, Bin Abdullah, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We describe the development of a dynamic simulation modelling framework to support agile resource planning during the
COVID-19 pandemic. The development of the modelling framework leverages on the Singapore COVID-19 scenario and was conceived to provide estimates of mortality, morbidity and the impact on waiting times to specialist appointments and elective surgeries, length
of stay (LOS) in the emergency department (ED), bed -demands and inpatient LOS and the utilization of critical hospital facilities (e.g., operating theatres, hospital and intensive care beds, isolation wards, diagnostic equipment, laboratory services). |
|
|
Sars-Cov-2 in Argentina: Following Virus Spreading using Granger
Causality |
Larrosa, JuanMC |
medRxiv |
Epidemiology| Épidémiologie |
The aim of this study is to use tools of time series analysis for understanding processes of the pandemic through regions
of Argentina. Results show that in the case of Argentina, contagion began in the capital city of Buenos Aires and then spread to its hinterland via specific districts. Once interior districts were infected a positive feedback dynamics emerge creating regions
of high reproducibility of the virus where interventions may be focus in the very near future. |
|
Symptoms and Transmission of SARS-CoV-2 among Children-Utah and Wisconsin, March-May 2020 |
Laws, RL, Chancey, et al |
Pediatrics |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
This study describes a cohort of children exposed to SARS-CoV-2 in the household and their resulting infection rates,
transmission patterns, and symptom profiles. We enrolled individuals with COVID-19 and their household contacts, assessed daily symptoms prospectively for 14 days, and obtained specimens for SARS-CoV-2 RT-PCR and serology testing. Results find that secondary
infection rates for adults (30%) and children (28%) were similar. Among households with potential for transmission from children, child-to-adult transmission may have occurred in 2/10 (20%), and child-to-child transmission may have occurred in 1/6 (17%). Pediatric
case-patients most commonly reported headache (79%), sore throat (68%), and rhinorrhea (68%). |
|
Diagnostic radiographers’ experience of COVID-19, Gauteng South Africa |
Lewis, S, Mulla, et al |
Radiography |
Healthcare Response | Réponse des soins de santé |
This study undertook to explore diagnostic radiographers’ experiences of COVID-19 in Gauteng province (South Africa)
as they were the greatest contributors of COVID-19 infections in the province. Sixty diagnostic radiographers representing both the private and public health sector responded to the questionnaire. Thematic analysis revealed three themes: new work flow and
operations, effect on radiographer well-being and radiographer resilience. |
|
32941803; High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models |
Li, W, Schäfer, et al |
Cell |
Therapeutics| Thérapeutique Animal model | Modèle animal |
We generated a phage-displayed human antibody VH domain library from which we identified a high-affinity VH binder
ab8. Bivalent VH, VH-Fc ab8, bound with high avidity to membrane-associated S glycoprotein and to mutants found in patients. It potently neutralized mouse-adapted SARS-CoV-2 in wild-type mice at a dose as low as 2 mg/kg and exhibited high prophylactic and
therapeutic efficacy in a hamster model of SARS-CoV-2 infection, possibly enhanced by its relatively small size. Electron microscopy combined with scanning mutagenesis identified ab8 interactions with all three S protomers and showed how ab8 neutralized the
virus by directly interfering with ACE2 binding. VH-Fc ab8 did not aggregate and did not bind to 5,300 human membrane-associated proteins. The potent neutralization activity of VH-Fc ab8 combined with good developability properties and cross-reactivity to
SARS-CoV-2 mutants provide a strong rationale for its evaluation as a COVID-19 therapeutic. |
|
Lim, H, Baek, et al |
Sci Rep |
Coronavirology| Coronavirologie |
In order to find hot spot residues, the strongly attracting amino acid pairs at the protein–protein interaction (PPI)
interface, we introduce a reliable inter-residue interaction energy calculation method, FMO-DFTB3/D/PCM/3D-SPIEs. In addition to the SARS-CoV-2 spike glycoprotein/hACE2 complex, the hot spot residues of SARS-CoV-1 spike glycoprotein/hACE2 complex, SARS-CoV-1
spike glycoprotein/antibody complex, and HCoV-NL63 spike glycoprotein/hACE2 complex were obtained using the same FMO method. Following this, a 3D-SPIEs-based interaction map was constructed with hot spot residues for the hACE2/SARS-CoV-1 spike glycoprotein,
hACE2/HCoV-NL63 spike glycoprotein, and hACE2/SARS-CoV-2 spike glycoprotein complexes. Finally, the three 3D-SPIEs-based interaction maps were combined and analyzed to find the consensus hot spots among the three complexes. As a result of the analysis, two
hot spots were identified between hACE2 and the three spike proteins. In particular, E37, K353, G354, and D355 of the hACE2 receptor strongly interact with the spike proteins of coronaviruses. The 3D-SPIEs-based map would provide valuable information to develop
anti-viral therapeutics that inhibit PPIs between the spike protein of SARS-CoV-2 and hACE2. |
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Active compounds activity from the medicinal plants against SARS-CoV-2 using in silico assay |
Linda Laksmiani, NP, Febryana Larasanty, et al |
Biomedical and Pharmacology Journal |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The objective of this research is to determine the inhibitory ability of several active compounds from natural sources
against COVID-19 target protein in silico using molecular docking. In silico research was conducted using autodock 4.2 program by evaluating the binding energy between the active compound with ACE2, TMPRSS2, RdRp, 3CLpro and PLpro as the target proteins. All
chemical compounds that evaluated such as asiatic acid, andrographolide, apigenin, brazilein, brazilin, catechin, curcumin, gingerol, hesperidin, hesperetin, kaemferol, luteolin, myricetin, naringenin and quercetin had an affinity to target protein. It reflects
that active compounds in medicinal plants can be used as antiviral against COVID-19. Brazilein and brazilin from secang wood (Caesalpinia sappan L.) have a superior bond to ACE2 and lower binding energy value than chloroquine, arbidol, remdesivir, ribavirin
and lopinavir. Citrus sp containing hesperidin had an excellent affinity to TMPRSS2. Secang wood and citrus sp. could be developed as an anti-SARS-CoV-2 through inhibiting ACE2, TMPRSS2, RdRp and protease (3CLpro and PLpro) that interfered the process of virus
infection at the entry, replication and advanced stages, causing worst effect such as pneumonia. |
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Liu, C, Huang, et al |
Frontiers in Oncology |
Clinical data| Données cliniques |
We retrospectively analyzed the diagnosis and treatment of six gynecological cancer patients infected with SARS-CoV-2
in Tongji Hospital in Wuhan from January 30 to March 25, 2020. We summarized the case characteristics, auxiliary examination, treatment plan, and outcome of these six patients. We observed a high rate of nosocomial SARS-CoV-2 infection among these six gynecological
cancer patients, who were in a low immune state. Also, due to the influence of cancer treatment history, COVID-19-related atypical symptoms became the first symptom of COVID-19 in some cases, which increased the difficulty of diagnosis. Furthermore, in terms
of treatment for these cases, immune boosters and reagents that raised white blood cells were applied, except for in symptomatic antiviral treatment. At present, all patients in this study were discharged from the hospital with a good prognosis. |
|
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Liu, J, Zhang, et al |
Respiratory medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of our study was to explore the association between sex and clinical outcomes in patients with COVID-19.
There were 635 (53.4%) male and 555 (46.6%) female patients in this study. Higher rates of acute kidney injury (5.5% vs. 2.9%, p = 0.026), acute cardiac injury (9.1% vs. 4.3%, p = 0.001), and disseminated intravascular coagulation (2.5% vs. 0.7%, P = 0.024)
were observed in males. Compared with female patients, male patients with COVID-19 had a higher inhospital mortality rate (15.7% vs. 10.3%, p = 0.005). However, Cox regression analysis showed that sex did not influence inhospital mortality of COVID-19 patients. |
|
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Liu, K, He, et al |
One Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this analysis, we observed that human development index (an integrated index of life expectation, education and
living standard) correlates with infection rate (proportion of confirmed cases among the population) and the fatality rate of COVID-19 in Italy based on data as of May 15, 2020. Further analysis showed that HDI is negatively correlated with cigarette consumption,
whereas it is positively correlated with chronic disease and average annual gross salary. These factors may partially explain why unexpected positive correlation is observed between human development index and risk of infections and deaths of COVID-19 in Italy. |
|
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Liu, T, Guo, et al |
Frontiers in Pharmacology |
Therapeutics| Thérapeutique Animal model | Modèle animal |
In this study, we investigated ShenFuHuang formula (SFH), a traditional Chinese medicine, which has been widely used
as complementary therapy for clinical treatment of COVID-19 in Wuhan, to understand its pharmacological properties. Results of systems pharmacology identified 49 active compounds of SFH and their 69 potential targets, including GSK3β, ESR1, PPARG, PTGS2, AKR1B10,
and MAPK14. Network analysis illustrated that the targets of SFH may be involved in viral disease, bacterial infection/mycosis, and metabolic disease. Moreover, signaling pathway analysis showed that Toll-like receptors, MAPK, PPAR, VEGF, NOD-like receptor,
and NF-kappa B signaling pathways are highly connected with the potential targets of SFH. We further employed multiple zebrafish models to confirm the pharmacological effects of SFH. Results showed that SFH treatment significantly inhibited the inflammatory
damage by reducing the generation of neutrophils in Poly (I:C)-induced viral infection model. Moreover, SFH treatment could improve the phagocytosis of macrophages and enhance the expression of immune genes in an immune deficiency model. Furthermore, SFH treatment
exhibited promising anti-thrombosis effect in a thrombus model. This study provided additional evidence of SFH formula for treating COVID-19 patients with septic syndrome using multiple-scale estimation. |
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Long, C, Fu, et al |
World Journal of Clinical Cases |
Epidemiology| Épidémiologie |
Of the 61 most affected countries by coronavirus disease 2019 (COVID-19), 12 static-phase countries including the United
States were characterized by largely constant numbers of daily new cases in the past over 14 d. Furthermore, these static-phase countries were overall significantly lower in testing density but higher in the level of positive COVID-19 tests than downward countries.
These findings suggested that daily new cases (confirmed) in these countries were likely less than daily new infections, resulting in an unstoppable epidemic. |
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HLA genetic polymorphisms and prognosis of patients with COVID-19 |
Lorente, L, Martín, et al |
Medicina Intensiva |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objectives of this study were to determine whether there is an association between HLA genetic polymorphisms and
the susceptibility to and mortality of COVID-19 patients from the Canary Islands (Spain). Findings show that HLA genetic polymorphisms could be associated with COVID-19 mortality; however, studies with a larger sample size before definitive conclusions can
be drawn. |
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COVID-19 Associated With Life-Threatening Apnea in an Infant Born Preterm: A Case Report |
Loron, G, Tromeur, et al |
Frontiers in Pediatrics |
Clinical data| Données cliniques |
We report the case of an infant, who presented with life-threatening apneas at home requiring basic life support. SARS-CoV-2
was subsequently identified in the patient's nasopharyngeal aspirate. He did not present with bronchiolitis or hypoxic failure as described in severe forms of COVID−19. The outcome was favorable in a few hours. The occurrence of apneas is not uncommon during
viral respiratory infections in early infancy; however, there are very few descriptions related to a documented SARS-CoV-2 respiratory tract infection. In light of this clinical case, it seems necessary to quickly bring up a potential COVID-19 contamination
in infants admitted for life-threatening apnea, in order to properly report and isolate these patients to avoid further nosocomial dissemination of SARS-CoV-2. |
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Luetkens, T, Metcalf, et al |
Blood Adv |
Clinical data| Données cliniques |
A severely immunocompromised patient with MM and COVID19 who received a convalescent plasma product showed SARS-CoV-2
clearance. The convalescent plasma showed humoral immunity against all structural SARS-CoV-2 proteins, which was successfully transferred to the patient. |
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Risk and resilience during COVID-19: A new study in the Zigler paradigm of developmental science |
Luthar, SS, Ebbert, et al |
Dev Psychopathol |
Public Health response| Interventions de santé publique |
The new study was conducted during the first two months of the pandemic, using a mixed-methods approach with a sample
of over 2,000 students across five high schools. Overall, rates of clinically significant symptoms were generally lower as compared to norms documented in 2019. Multivariate regressions showed that the most robust, unique associations with teens’ distress
were with feelings of stress around parents and support received from them. Open ended responses to three questions highlighted concerns about schoolwork and college, but equally, emphasized worries about families’ well-being, and positive outreach from school
adults. |
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Lv, D, Chen, et al |
Annals of Palliative Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A retrospective analysis of 137 patients with COVID-19-induced pneumonia who were discharged from the Enze Hospital,
Taizhou Enze Medical Center (Group) from January 31 2020 to March 11 2020 was conducted. Our results demonstrated that the pulmonary function of patients with COVID-19-induced pneumonia predominantly manifested as restrictive ventilation disorder and small
airway obstruction, which was increased in critically ill patients. |
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Children and Adolescents With SARS-CoV-2 Infection: Epidemiology, Clinical Course and Viral
Loads |
Maltezou, HC, Magaziotou, et al |
Pediatr Infect Dis J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We studied 203 SARS-CoV-2-infected children (median age: 11 years; range: 6 days to 18.4 years); 111 (54.7%) had an
asymptomatic infection. Among the 92 children (45.3%) with coronavirus disease 2019 (COVID-19), 24 (26.1%) were hospitalized. Infants <1 year were more likely to develop COVID-19 (19.5% of all COVID-19 cases) (P-value = 0.001). There was no significant difference
between viral load and age, sex, underlying condition, fever and hospitalization, as well as between type of SARS-CoV-2 infection and age, sex, underlying condition and viral load. Transmission from a household member accounted for 132 of 178 (74.2%) children
for whom the source of infection was identified. An adult member with COVID-19 was the first case in 125 (66.8%) family clusters. Child-to-adult transmission was found in one occasion only. |
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Manthei, DM, Whalen, et al |
Am J Clin Pathol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study examines the differences in performance characteristics among four assays for antibody detection against
SARS-CoV-2. Samples from SARS-CoV-2 RT-PCR–positive patients became increasingly positive as time from symptom onset increased. For patients with latest sample 14 or more days after symptom onset, sensitivities reached 93.1% to 96.6%, 98.3%, and 96.6% for
EUROIMMUN, Roche, and Siemens assays, respectively, which were superior to the DiaSorin assay at 87.7%. The specificity of Roche and Siemens assays was 100% and superior to DiaSorin and EUROIMMUN assays, which ranged from 96.1% to 97.0% and 86.3% to 96.4%,
respectively. |
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Epidemiological analysis of 67 local COVID-19 clusters in Sichuan Province, China |
Mao, S, Huang, et al |
BMC Public Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study was intended to investigate the epidemiological characteristics of COVID-19 clusters and the severity distribution
of clinical symptoms of involved cases in Sichuan Province. The clusters were temporally and regionally concentrated. Clusters caused by imported cases from other provinces accounted for 73.13%; familial clusters accounted for 68.66%; the average attack rate
was 8.54%, and the average secondary attack rate was 6.11%; the median incubation period was 8.5 d; a total of 28 cases met the criteria for incubation period determination, and in the 28 cases, the incubation period was > 14 d in 21.43% (6/28). a total of
226 confirmed cases were reported in the 67 clusters. Ten cases were exposed before the confirmed cases they contacted with developed clinical symptoms, and the possibility of exposure to other infection sources was ruled out; two clusters were caused by asymptomatic
carriers; confirmed cases mainly presented with fever, respiratory and systemic symptoms; a gradual decline in the severity of clinical symptoms was noted with the increase of the case generation. |
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Márquez, S, Prado-Vivar, et al |
Microbiol Resour Announc |
Clinical data| Données cliniques |
We report the metagenome analysis of a bronchoalveolar lavage (BAL) fluid sample from a confirmed coronavirus disease
2019 (COVID-19) case in Quito, Ecuador. Sequencing was performed using MinION technology. |
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Martins, LD, da Silva, et al |
Environmental research |
Epidemiology| Épidémiologie |
We explore the relations of COVID-19 and Influenza with atmospheric variables and socio-economic conditions for tropical
and subtropical climates in Brazil. The Temperature combined with humidity are risk factors for COVID-19 and Influenza. Social-economic inequalities are the most important risk factors for COVID-19. COVID-19 may have seasonality similar to that of Influenza.
The highest RR occurred usually in 3 days (lag = 3) for the entire set of variables. |
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Mason, SE, Scott, et al |
PLoS One |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to evaluate COVID-19 impact on colorectal cancer services globally and identify predictors
for behaviour change. Diagnostic endoscopy was reduced in 93% of responses, even with low hospital stress and mortality; whilst rising critical care bed stress triggered complete cessation (p = 0.02). Availability of CT and MRI fell by 40–41%, with MRI significantly
reduced with high hospital stress. Neoadjuvant therapy use in rectal cancer changed in 48% of responses, where centers which had ceased surgery increased its use (62 vs 30%, p = 0.04) as did those with extended delays to surgery (p<0.001). High hospital and
critical care bed stresses were associated with surgeons forming more stomas (p<0.04), using more experienced operators (p<0.003) and decreased laparoscopy use (critical care bed stress only, p<0.001). Patients were also more actively prioritized for resection,
with increased importance of co-morbidities and ICU need. |
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Mathew, N, Deborah, et al |
Health Care Women Int |
Public Health response| Interventions de santé publique |
The researchers explored the impact the of COVID-19 lockdown on self-employed women. The researchers used a qualitative
approach. Interviews were used to collect data. Forty participants took part in the study. The data was thematically analyzed. The researchers found that participants were affected by Inadequate food supplies, Hopelessness to revive business, Poor access to
health services, Psychological trauma, Defaulting medications, and Challenges of keeping children indoors. There is need to provide social and economic support to self-employed women. |
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IMPACT OF COVID-19 QUARANTINE AND SCHOOL
CANCELATION ON OTHER COMMON INFECTIOUS DISEASES |
McBride, JA, Eickhoff, et al |
Pediatr Infect Dis J |
Public health interventions*| Interventions de santé publique |
Coronavirus disease 2019 lead to wide-spread quarantines and cancelations. The impact of these measures on other, noncoronavirus
disease 2019 , infectious diseases was analyzed within Dane County, Wisconsin. The incidence of streptococcal pharyngitis and acute otitis media decreased during quarantine while gonorrhea increased. Quarantine had the expected result for infections spread
via the respiratory route but a different effect from those transmitted through sexual activity. |
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Temperature Screening for SARS-CoV-2 in Nursing Homes: Evidence from Two National
Cohorts |
McConeghy, KW, White, et al |
J Am Geriatr Soc |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We evaluate temperature trends among nursing home residents undergoing diagnostic SARS‐CoV‐2 testing and describe the
diagnostic accuracy of temperature measurements for predicting test‐confirmed SARS‐CoV‐2 infection. The Veterans Affairs (VA) cohort includes 1,301 residents in 134 facilities from 03/01/2020 to May 14, 2020, with 25% confirmed for SARS‐CoV‐2. The community
cohort includes 3,368 residents spread across 282 facilities from February 18, 2020 to 06/09/2020, and 42% confirmed for SARS‐CoV‐2. The VA cohort was younger, less Caucasian and mostly male. A temperature testing threshold of 37.2°C has better sensitivity
for SARS‐CoV‐2, 76% and 34% in the VA and community NH respectively vs 38.0°C with 43% and 12% sensitivity respectively. |
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Impact of the COVID-19 pandemic on job search behavior: An event transition perspective |
McFarland, LA, Reeves, et al |
J Appl Psychol |
Public Health response| Interventions de santé publique |
This study examines how job search behavior changed at the onset of the COVID-19 pandemic, the weeks following the
event’s onset, and if the physical contact required by different jobs moderated these trends. Results show that the onset of the pandemic created an immediate increase in job search behavior (job applications), and this effect endured into the postonset period.
Job type moderated these trends, such that the onset and postonset applications were substantially greater for work-from-home jobs (which followed a negatively accelerated curve) compared to face-to-face jobs. |
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Mehr, SGD, Ayatollahi, et al |
International Journal of Cancer Management |
Clinical data| Données cliniques |
We present the case of a 34-year-old woman with choriocarcinoma, complicated by uterine rupture after the first course
of chemotherapy, and concurrent COVID-19 infection. The patient underwent an emergency hysterectomy and survived after transferring to an isolated intensive care unit room. |
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Melandro, F, Ghinolfi, et al |
Transpl Int |
Healthcare Response | Réponse des soins de santé |
Although preliminary reports emphasized on an initial decline in organ procurement and liver transplantation (LT) in
Italy (1-2), three months after enforcement of the coronavirus disease-19 (COVID-19) national lockdown data are better than anticipated. At our center in Tuscany, from February 18 to May 4, 2020 (end of lockdown) a total of 39 procedures were performed, namely
29 deceased donor LTs and 10 more brain dead donor surgeries resulting in liver grafts unsuitable for transplantation. |
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Clinical application of combined detection of SARS-CoV-2-specific antibody and nucleic acid |
Meng, QB, Peng, et al |
World Journal of Clinical Cases |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
AIM To investigate the diagnostic value of SARS-CoV-2 IgM/IgG and nucleic acid detection in COVID-19. We retrospectively
analyzed 652 suspected COVID-19 patients, and 206 non-COVID-19 patients in Wuhan. Of the 652 suspected COVID-19 patients, 237 (36.3%) had positive nucleic acid tests, 311 (47.7%) were positive for IgM, and 592 (90.8%) were positive for IgG. There was a significant
difference in the positive detection rate between the IgM and IgG test groups (P < 0.001). Using the RT-PCR results as a reference, the specificity, sensitivity, and accuracy of IgM/IgG combined tests for SARS-CoV-2 infection were 98.5%, 95.8%, and 97.1%,
respectively. Of the 415 suspected COVID-19 patients with negative nucleic acid test results, 366 had positive IgM/IgG tests with a positive detection rate of 88.2%. |
|
Miranda, Renan Lyra, Guterres, et al |
medRxiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this study, we compared tracheal aspirate with nasopharyngeal samples obtained from critically ill COVID-19 patients
and demonstrate how the raw cycle threshold (Ct) could lead to misinterpretation of results. Further, we analyzed nasopharyngeal swabs positive samples and propose a method to reduce evaluation error that could occur from using raw Ct. Based on these findings,
we show the impact that normalization of Ct values has on interpretation of viral load data from different biological samples from patients with COVID-19, transmission and lastly in relations with clinical outcomes. |
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Mohamed Ibrahim, O, Ibrahim, et al |
Telemed J E Health |
Healthcare Response | Réponse des soins de santé |
Objective: To assess the predictors for effective telepharmacy services on increasing access of patients to care and
reducing dispensing errors in community pharmacies .This is a prospective study carried out for 4 months in 52 community pharmacies across the United Arab Emirates (UAE) using disguised direct observation. Pharmacist recommendations related to COVID-19 at
pharmacies with telepharmacy (n = 63,714) versus those without remote services (n = 15,539) were significantly more likely to be (1) contact the nearest testing center (adjusted odds ratio [AOR] = 7.93), (2) maintain home quarantine (AOR = 5.64), and (3) take
paracetamol for fever (AOR = 3.53), all were significant results (p < 0.05). Rates of medication dispensing errors (MDEs) and its subcategories, prescription-related errors, and pharmacist counseling errors across pharmacies with telepharmacy versus those
without remote services were (15.81% vs. 19.43%, p < 0.05), (5.38% vs. 10.08%, p < 0.05), and (10.42% vs. 9.35%, p > 0.05), respectively. However, pharmacies with telepharmacy were more likely to include wrong patient errors (AOR = 5.38, p < 0.05). |
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Mohamed, MO, Gale, et al |
Mayo Clinic proceedings |
Epidemiology| Épidémiologie |
Of 144,279 adult deaths recorded during the study period, 36,438 (25.3%) were confirmed COVID deaths. Women represented
43.2% (n=15,731) of COVID deaths compared with 51.9% (n=55,980) in non-COVID deaths. Overall, COVID deaths were younger than non-COVID deaths (82 vs 83 years). Age-standardized mortality rate (ASMR) of COVID-19 was higher than all other common primary causes
of death, across age groups and sexes, except for cancers in women between the ages of 30 and 79 years. A linear relationship was observed between ASMR and age among COVID-19 deaths, with persistently higher rates in men than women across all age groups. The
most prevalent reported conditions were hypertension, dementia, chronic lung disease, and diabetes, and these were higher among COVID deaths. Pre-existing ischemic heart disease was similar in COVID (11.4%) and non-COVID (12%) deaths. |
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Mohammadzadeh, F, Delshad Noghabi, et al |
Archives of Iranian medicine |
Public Health response| Interventions de santé publique |
The current study aims to determine the anxiety severity level, coping strategies, and influencing factors in response
to the COVID-19 pandemic among people aged 15 years and above in Gonabad, Iran. Totally, 500 people completed the questionnaires (response rate: 73%). Of them, 53.4% (95% confidence interval [CI]: 48.9%- 57.8%) suffered moderate to severe levels of anxiety.
More than half of the respondents (52.0%; 95% CI: 47.5%-56.4%) utilized emotional-based or avoidant coping strategies. People with no academic education (odds ratio [OR]: 2.16; 95% CI: 1.41- 3.31) and without physical exercise (OR: 2.04; 95% CI: 1.22-3.33)
preferred emotional-based coping instead of problem-based coping strategy. Female gender (OR: 1.60, 95%, CI: 1.13-2.28), underlying medical conditions (OR: 2.52, 95% CI: 1.65-3.87), and emotional-based coping (OR: 4.06, 95% CI: 2.76-5.99) were associated with
higher severity levels of anxiety. |
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32941977; Optimization and clinical validation of dual-target RT-LAMP for SARS-CoV-2 |
Mohon, AN, Oberding, et al |
Journal of virological methods |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
A novel reverse-transcriptase loop mediated amplification (RT-LAMP) method targeting genes encoding the Spike (S) protein
and RNA-dependent RNA polymerase (RdRP) of SARS-CoV-2 has been developed. The LAMP assay achieves a comparable limit of detection (25–50 copies per reaction) to commonly used RT-PCR protocols using clinical samples quantified by digital droplet PCR. Precision,
cross-reactivity, inclusivity, and limit of detection studies were performed according to regulatory standards. Clinical validation of dual-target RT-LAMP (S and RdRP gene) achieved a PPA of 98.48 % (95 % CI 91.84%–99.96%) and NPA 100.00 % (95 % CI 93.84%–100.00%)
based on the E gene and N2 gene reference RT-PCR methods. The method has implications for development of point of care technology using isothermal amplification. © 2020 The Author(s) |
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Monin, JK, Ali, et al |
American Journal of Geriatric Psychiatry |
Public Health response| Interventions de santé publique |
The objective was to examine what communication methods, other than in-person visits, during the pandemic were associated
with greater positive and lower negative emotional experiences for long-term care (LTC) residents and their family members and friends. During the pandemic, greater phone frequency was associated with less participant negative emotions (β = −0.17). Greater
e-mail frequency was associated with more perceived resident positive emotions (β = 0.28). Greater frequency of letters delivered by staff was associated with more participant negative emotions (β = 0.23). Greater frequency of letters delivered by staff and
the postal service were associated with more perceived resident negative emotions (β = 0.28; β = 0.34, respectively). |
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Partnering with Local Hospitals and Public Health to Manage COVID-19 Outbreaks in
Nursing Homes |
Montoya, A, Jenq, et al |
J Am Geriatr Soc |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
A total of 29 cases of COVID‐19 were identified at three participating nursing homes (NHs).. Nineteen cases of COVID‐19
were identified through symptom‐triggered testing from March 23–April 23, 2020; 10 (4.7%) additional cases were identified through universal testing of 215 residents conducted April 7–15, 2020. The hospitalization rate was 37.9%. The case fatality rate was
20.7% (6/29); these cases had multiple comorbidities. No residents who tested positive through the point‐prevalence survey required hospitalization, and four were discharged home within fourteen days. |
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Moolasart, Visal, Manosuthi, et al |
Research Square prepub |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
We conducted a national cross-sectional survey of HCWs in the infection control program in Thailand between May 5,
2020 and May 15, 2020. The primary objective was the prevalence of optimized PPE use amongst HCWs. The secondary objective was identification of the independent predictors of optimized PPE use. Seven hundred and fifty-six HCWs responded. Five HCWs were excluded
because of non responsible of care team, and 751 were included in the final analysis. The prevalence of optimized PPE use was 22 % (168/751), 78% (583/751) were non-optimized PPE use, 35% (263/751) over-used PPE, and 43% (320/751) under-used PPE. In univariate
analysis, optimized PPE use was significantly associated with age, education level, knowledge of appropriate negative pressure room selection and knowledge of apparently milder symptom severity in children than adults. In multivariate analysis, independent
predictors of optimized PPE use were knowledge of appropriate negative pressure room selection (aOR=1.95, 95% CI=1.18-3.22) , the difference in symptom severity between children and adults (aOR=0.55, 95% CI=0.37-0.81) and education level (aOR=1.54, 95% CI=1.04-2.27). |
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|
Morris, SB, Schwartz, et al |
MMWR Morb Mortal Wkly Rep |
Clinical data| Données cliniques |
What is added by this report? Cases reported to CDC and published case reports and series identify MIS-A in adults,
who usually require intensive care and can have fatal outcomes. Antibody testing was required to identify SARS-CoV-2 infection in approximately one third of 27 cases. |
|
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Motiwale, M, Yadav, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In the current study, we applied the molecular docking approach in conjugation with molecular dynamics (MD) simulations
to find out potential inhibitors against Mpro of SARS-CoV-2 from previously reported SARS-3CL protease inhibitors. Our results showed that N-substituted isatin derivatives and pyrazolone compounds could be used as a potent inhibitor and may possess an anti-viral
activity against SARS-CoV-2. |
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Intravenous immunoglobulin therapy in COVID-19-related encephalopathy |
Muccioli, L, Pensato, et al |
J Neurol |
Clinical data| Données cliniques |
We retrospectively collected data on all patients with COVID-19 hospitalized at two Italian hospitals who developed
encephalopathy during disease course and were treated with IVIg. Five patients (two females, mean age 66.8 years) developed encephalopathy after a mean of 12.6 days, since the onset of respiratory/constitutional symptoms related to COVID-19. Four patients
suffered severe respiratory distress, three of which required invasive mechanical ventilation. Neurological manifestations included impaired consciousness, agitation, delirium, pyramidal and extrapyramidal signs. EEG demonstrated diffuse slowing in all patients.
Brain MRI showed non-specific findings. CSF analysis revealed normal cell count and protein levels. In all subjects, RT-PCR for SARS-CoV-2 in CSF tested negative. IVIg at 0.4 g/kg/die was commenced 29.8 days (mean, range: 19–55 days) after encephalopathy onset,
leading to complete electroclinical recovery in all patients, with an initial improvement of neuropsychiatric symptoms observed in 3.4 days (mean, range: 1–10 days). No adverse events related to IVIg were observed. Our preliminary findings suggest that IVIg
may represent a safe and effective treatment for COVID-19-associated encephalopathy. |
|
Mukherjee, UjjalK, Bose, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We build an epidemiological model to investigate the strategies necessary for educational institutions to safely reopen.
We show that increasing the testing levels from 0.2 per capita per day to 0.3 per capita per day can reduce the infectivity from 0.25 to 0.01. We also cross-validate the results with data from a large number of universities in the United States, and show
that institutions with higher levels of testing are associated with lower infections. We estimate from data on 228 different universities across the United States that an increase of infection rate at the county where a university is located by 1% has the
potential to increase the institutional infection rate by an average of 0.14% with a 99% confidence interval of [0.032%, 0.248%] across all universities. |
|
|
32975575; Racial Disparities in Incidence and Outcomes Among Patients With COVID-19 |
Muñoz-Price, LS, Nattinger, et al |
JAMA network open |
Epidemiology| Épidémiologie |
Objective: To characterize the association of race with incidence and outcomes of COVID-19, while controlling for age,
sex, socioeconomic status, and comorbidities. A total of 2595 patients were included. Of the 369 patients (14.2%) who tested positive for COVID-19, 170 (46.1%) were men, 148 (40.1%) were aged 60 years or older, and 218 (59.1%) were African American individuals.
Positive tests were associated with Black race (odds ratio [OR], 5.37; 95% CI, 3.94-7.29; P = .001), male sex (OR, 1.55; 95% CI, 1.21-2.00; P = .001), and age 60 years or older (OR, 2.04; 95% CI, 1.53-2.73; P = .001). Black race (OR, 1.85; 95% CI, 1.00-3.65;
P = .04) and poverty (OR, 3.84; 95% CI, 1.20-12.30; P = .02) were associated with hospitalization. Poverty (OR, 3.58; 95% CI, 1.08-11.80; P = .04) but not Black race (OR, 1.52; 95% CI, 0.75-3.07; P = .24) was associated with intensive care unit admission.
Overall, 20 (17.2%) deaths associated with COVID-19 were reported. Shortness of breath at presentation (OR, 10.67; 95% CI, 1.52-25.54; P = .02), higher body mass index (OR per unit of body mass index, 1.19; 95% CI, 1.05-1.35; P = .006), and age 60 years or
older (OR, 22.79; 95% CI, 3.38-53.81; P = .001) were associated with an increased likelihood of death. |
|
Murt, A, Dincer, et al |
Blood Purif |
Clinical data| Données cliniques |
We herein present 2 cases of sudden cardiac death in 2 ESRD patients with COVID-19 for whom a treatment regimen including
HQ was preferred. Both patients were clinically stable at the time of arrest. Death could not be attributed to worsening of the COVID-19 since the patients’ clinical picture and laboratory values were improving. The cardiac events coincided with the end of
routine haemodialysis sessions of both patients. |
|
|
Nasir, EF, Elhag, et al |
Eur J Dent |
Healthcare Response | Réponse des soins de santé |
A cross-sectional online survey to assess COVID-19 related perceptions and possible disparities between them in Saudi
Arabia. There was a clear disparity in the perceptions among the different categories of participants. More emphasis on the training and preparedness of the dental healthcare personnel is required. |
|
|
SARS-CoV-2 Elicits Robust Adaptive Immune Responses Regardless of
Disease Severity |
Nielsen, Stine Sofie Frank, Vibholm, et al |
bioRxiv |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
We investigated the breadth and potency of antibody-, and T-cell immune responses, in 203 recovered SARS-CoV-2 infected
patients who presented with asymptomatic to severe infections. Overall, the majority of patients had robust adaptive immune responses, regardless of disease severity. These data support the possibility of achieving protective immunity through natural infection
and bode well for the prospects of inducing immunological memory through vaccination. |
|
The Opioid Epidemic Within the COVID-19 Pandemic: Drug Testing in 2020 |
Niles, JK, Gudin, et al |
Popul Health Manag |
Healthcare Response | Réponse des soins de santé |
The authors analyzed changes in clinical drug testing patterns and results at a national clinical laboratory, comparing
data obtained before and during the pandemic. Testing for prescription and illicit drugs declined rapidly during the pandemic. The convergence of the drug abuse epidemic and COVID-19 pandemic has led to an increased need for health care and public health resources
dedicated to supporting vulnerable patients and addressing the underlying causes of these disturbing trends. |
|
Nouchi, A, Chastang, et al |
Eur J Clin Microbiol Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Our objective was to describe the prevalence of hyposmia and hypogeusia and compare it in hospitalized and non-hospitalized
COVID-19 patients to evaluate an association of these symptoms with disease severity. Hyposmia and hypogeusia appeared more frequently after other COVID-19 symptoms. Patients with hyposmia and/or hypogeusia were significantly younger and had significantly
less respiratory severity criteria than patients without these symptoms. |
|
|
Angiotensin II Administration in Patients with COVID-19 Shock |
Ofosu-Barko, K, Liu, et al |
Crit Pathw Cardiol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
A retrospective analysis was performed to understand the hemodynamic effect of angiotensin II as a vasopressor in patients
with shock secondary to COVID-19 infection. On average, the hemodynamic response to angiotensin II in COVID-19 related shock was favorable. Two patients had a marked rapid improvement. |
|
Opota, O, Brouillet, et al |
Pathog Dis |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The aim of this study was to compare the RT-PCR results obtain with the MDx Platform and the commercial assay cobas
SARS-CoV-2 (Roche) on nasopharyngeal swab and other clinical specimens including sputum, bronchial aspirate, bronchoalveolar lavage and anal swabs. The high agreements between the cobas SARS-CoV-2 test and the MDx platform supports the use of both methods
for the diagnostic of COVID-19 on various clinical samples. Very few discrepant results may occur at very low viral load. |
|
|
Pan, Y, Xin, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
The aim of this study was to investigate the associations between exposure to COVID-19–specific information and mental
health (depression and sleep quality) and self-reported compliance with personal preventive measures (face mask wearing and hand sanitizing). This study provides empirical evidence of how the amount, sources, and contents of information to which people were
exposed influenced their mental health and compliance with personal preventive measures at the initial phase of work resumption in China. |
|
|
Excessive G-U transversions in novel allele variants in SARS-CoV-2 genomes |
Panchin, AY, Panchin, et al |
PeerJ |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
A comparison between patterns of mutations that occurred before and after SARS-CoV-2 jumped to human hosts may reveal
important evolutionary consequences of zoonotic transmission. We used publically available complete genomes of SARS-CoV-2 to calculate relative frequencies of single nucleotide variations. We found a 9-fold excess of G–U transversions among SARS-CoV-2 mutations
over relative substitution frequencies between SARS-CoV-2 and a close relative coronavirus from bats (RaTG13). This suggests that mutation patterns of SARS-CoV-2 have changed after transmission to humans. |
|
Risk Factors for Mortality of Patients with COVID-19 in Korea: A Nationwide Population-Based
Study |
Park, Se Jun, Lee, et al |
Research Square prepub |
Epidemiology| Épidémiologie |
We aimed to identify risk factors for the mortality of COVID-19 in the Republic of Korea without health system disruption.
We identified 7,333 COVID-19 patients, of whom 227 (3.1%) died. Male, elderly patients ˃65 years old, Medical Aid beneficiaries, higher CCI (≥3), and living in a large outbreak area might have a greater risk of mortality and comorbidities such as hypertension,
COPD, CHF, and ESRD could also greatly affect the mortality in COVID-19 patients. |
|
Pászto, V, Burian, et al |
International Journal of E-Planning Research |
Public Health response| Interventions de santé publique |
The article is focused on a detailed micro-study describing changes in the behaviour of the authors in three months
before and during the COVID-19 pandemic. The study is based on data from Google Location Service. Despite the fact it evaluates only three people and the study cannot be sufficiently representative, it is a unique example of possible data processing at such
a level of accuracy. |
|
|
Paul, S, Bhattacharya, et al |
Spatial Information Research |
Epidemiology| Épidémiologie |
The study primarily tries considering the nature of SARS-CoV-2 cases in different urban centres with the help of cartographic
techniques. AHP method has been used to determine the factors responsible for such concentration of SARS-CoV-2 cases with vulnerability assessment (exposure, sensitivity and resilience) and risks. |
|
|
Pedrozo-Pupo, J, Campo-Arias, et al |
Chronic Respiratory Disease |
Public Health response| Interventions de santé publique |
We aim to compare the prevalence of depression, perceived stress related to COVID, post-traumatic stress, and insomnia
in asthma and COPD patients at a pulmonology clinic in Santa Marta, Colombia. Asthma and COPD patients present similar frequencies of depression risk, COVID-19 perceived stress, post-traumatic stress risk, and insomnia risk during the Colombian lockdown. It
is essential to evaluate and manage psychological distress among asthma and COPD patients. |
|
|
Perdana, T, Chaerani, et al |
Heliyon |
Modelling/ prediction| Modélisation/prédiction Public Health response| Interventions
de santé publique Economics | Économie |
This paper discusses an optimization model for handling the impact of the COVID-19 pandemic based on food supply network
through regional food hubs (RFHs) under uncertainty. This paper determines the location and capacity of RFHs, the food supply network, the sum of maximum food supplies, and minimum logistics cost. The numerical experiment is considered for three scenarios:
when a region is in large-scale social distancing, partial social distancing, or normal conditions. This social distancing situation is based on the defined red zones. The optimal food supply network is obtained for the three scenarios and the best scenario
among the three is identified. |
|
|
Anxiety, depression, and stress in response to the coronavirus disease-19 pandemic |
Pérez-Cano, HJ, Moreno-Murguía, et al |
Cirugia y Cirujanos (English Edition) |
Public Health response| Interventions de santé publique |
The objective of the study was to determine the state of anxiety, depression, and stress present in the society during
the development of the 2019 coronavirus pandemic. There are emotional indicators derived from the 2019 coronavirus pandemic in almost half of the study population. The identification and timely treatment of these states could lessen the psychological impact
due to 2019 coronavirus. |
|
Prasanna Simha, P, Mohan Rao, et al |
Physics of Fluids |
Transmission Public health interventions*| Interventions de santé publique |
In this study, the schlieren method that is a highly sensitive, non-intrusive flow visualization technique is used.
It can directly image weak density gradients produced by coughs. An assessment of different methods of covering the mouth while coughing is arrived at by using observations from high speed schlieren images. The effectiveness of coughing into the elbow is examined. |
|
|
Rahaman, MM, Li, et al |
Journal of X-ray science and technology |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Develop an automated system for the detection of COVID-19 samples from healthy and pneumonia cases using Chest X-Ray
images. Based on the analysis of 860 images (260 COVID-19 cases, 300 healthy and 300 pneumonia cases), the deep learning framework VGG19 leads to the highest classification accuracy of 89.3% with an average precision, recall, and F1 score of 0.90, 0.89,
0.90, respectively. |
|
|
Rahimi, Zahra, Shirali, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
Estimate the prevalence of face mask usage and the distribution of face mask types among pedestrians in southwest Iran
during the Covid-19 pandemic. |
|
|
Rahman, MA, Hoque, et al |
Global Health |
Public Health response| Interventions de santé publique |
Cross-sectional survey of Australians conducted in June 2020 ( 587). Among responders, majority (71.5%) had a source
of income, (42.3%) self-identified as a frontline worker, (58.9%) reported financial impact due to COVID-19. Comorbidities such as pre-existing mental health conditions , increased smoking and alcohol drinking over the last four weeks, high levels of fear
and being female were associated with higher levels of psychological distress; while healthcare service use in the last four weeks was associated with medium to high resilience. |
|
|
Rajkumar, I, Anand, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Determine the true prevalence of olfactory dysfunction in COVID-19 patients by objective assessment in mild to moderate
symptomatic patients. Self-reported smell dysfunction was present in 26.9% patients (n=62) and taste dysfunction was seen in 10.9% (n=25) of patients. On quantitative assessment of smell dysfunction, it was noted that 41.3% (n=95) of patients had some form
of smell dysfunction out of which 70.5% patients (n=67) had hyposmia and 29.5% patients (n=28) had anosmia. |
|
|
From symptom tracking to contact tracing: A framework to explore and assess COVID-19 apps |
Ramakrishnan, AM, Ramakrishnan, et al |
Future Internet |
Public Health Priorities| Priorités de santé publique Public Health response| Interventions
de santé publique |
M-Health Index and Navigation Database (MIND) was adapted to guide the assessment of COVID apps. MIND was applied to
the thorough analysis of the top-100 returned coronavirus apps on two separate dates a month apart to understand the clinical utility and features of COVID-19 apps and how these change in a short period of time |
|
Ranjan, A, Muraleedharan, et al |
Global Health |
Public Health response| Interventions de santé publique |
The vulnerability of India’s elderly increases across economic levels, and other dimensions such as the place of residence,
gender, social group (caste), marital status, living arrangements, surviving children, and economic dependence. The current COVID-19 pandemic poses a greater risk of social isolation among the elderly, which may cause detrimental health impact. |
|
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32966814; AR12 (OSU-03012) suppresses GRP78 expression and inhibits SARS-CoV-2 replication |
Rayner, JO, Roberts, et al |
Biochemical pharmacology |
Coronavirology| Coronavirologie |
Determined whether AR12 could act against SARS-CoV-2; In a dose-dependent fashion AR12 inhibited SARS-CoV-2 spike protein
expression in transfected or infected cells. AR12 suppressed the production of infectious virions via autophagosome formation, which was also associated with degradation of GRP78. After AR12 exposure, the colocalization of GRP78 with spike protein was reduced.
Knock down of eIF2α prevented AR12-induced spike degradation and knock down of Beclin1 or ATG5 caused the spike protein to localize in LAMP2+ vesicles without apparent degradation. |
|
Recinella, G, Marasco, et al |
Aging Clin Exp Res |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
Nutritional status assessed by Geriatric Nutritional Risk Index is a significative predictor of survival in elderly
patients hospitalized for COVID-19. The association between GNRI and PaO2/FiO2 ratio is a good prognostic model these patients. |
|
|
Rewari, BB, Mangadan-Konath, et al |
WHO South-East Asia journal of public health |
Healthcare Response | Réponse des soins de santé |
Impacts of the COVID-19 lockdown on generic antiretroviral (ARV) drugs produced by manufacturers in India was surveyed.
The greatest challenges reported were in international shipping, including delays, increased lead times and rising costs. Contrary to expectations, lack of access to the active pharmaceutical ingredients (APIs) required for ARV drug manufacture was not a major
hindrance. |
|
|
Rossi, CM, Beretta, et al |
Clin Mol Allergy |
Clinical data| Données cliniques |
Report the case of 78-years-old woman with cardiometabolic syndrome and COVID-19. Patient started to display a violaceous
rash initially involving the flexural folds atypical targetoid lesions and showing a very fast extension, blister formation and skin detachments of approximately 70% of the total body surface area and mucous membranes involvement consistent with toxic epidermal
necrolysis (TEN) |
|
|
SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden |
Rudberg, AS, Havervall, et al |
Nat Commun |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé Immunology
| Immunologie |
Seroprevalence of SARS-CoV-2 antibodies, self-reported symptoms and occupational exposure to SARS-CoV-2 among healthcare
workers at a large acute care hospital in Sweden. The seroprevalence of IgG antibodies against SARS-CoV-2 was 19.1% (n=2149), higher than reported regional seroprevelance. Symptoms associated with seroprevalence were anosmia (odds ratio (OR) 28.4, 95% CI 20.6–39.5)
and ageusia (OR 19.2, 95% CI 14.3–26.1). Seroprevalence was also associated with patient contact (OR 2.9, 95% CI 1.9–4.5) and covid-19 patient contact (OR 3.3, 95% CI 2.2–5.3) |
|
Sadria, M, Layton, et al |
PLoS Comput Biol |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Developed a mathematical model that represents the renin-angiotensin system RAS, binding of ACE2 with SARS-CoV-2 and
the subsequent cell entry, and the host’s acute inflammatory response. The model can simulate different levels of SARS-CoV-2 exposure, and represent the effect of commonly prescribed anti-hypertensive medications, as ACE inhibitors (ACEi) and angiotensin
II receptor blockers (ARBs), and predict tissue damage. Model simulations indicate that whether the extent of tissue damage may be exacerbated by ACEi or ARB treatment depends on a number of factors, including the level of existing inflammation, dosage, and
the effect of the drugs on ACE2 protein abundance. |
|
|
Saha, S, Ahmed, et al |
Pediatr Infect Dis J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Provide an epidemiological and clinical report of SARS-CoV-2 infections in neonates (n=26) hospitalized in Bangladesh.
Most neonates were admitted with diagnosis unrelated to SARS-CoV-2; positive neonates were referred to government-designated COVID-19 hospitals, leading to gaps in treatment. Twenty-three neonates could be followed-up: 12 were healthy, 8 died ( 2 deaths directly
related to infection), and 3 were still seeking medical care. |
|
|
Salameh, P |
Eastern Mediterranean Health Journal |
Epidemiology| Épidémiologie |
The overall testing frequency was similar in the Eastern Mediterranean Region compared to the rest of the world; this
would be expected to lead to a similar cumulative incidence and case fatality rate. Nevertheless, the average incidence was 70% lower than the rest of the world, and mortality per million-population was lower (90%). Moreover, in Gulf Cooperation Council high-testing
countries, a similar case-fatality rate to other countries in the Region was noted, but was higher than the world average, although expected to be lower. Further studies are necessary to explain discrepancies in incidence, mortality and fatality rates among
countries |
|
|
Samimi Ardestani, Seyed Hadi, Mohammadi Ardehali, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Many patients with Coronavirus disease 2019 (COVID-19) complain from olfactory dysfunction (OD). Study evaluates the
prevalence, prognosis, and recovery of OD in COVID-19 patients (n=311). Headache, nasal obstruction, and platelet count may have specific roles as prognostic factors in the recovery from OD. Hence, the prognosis for OD might be dependent upon these components. |
|
|
Combining fragment docking with graph theory to improve ligand docking for homology model structures |
Sarfaraz, S, Muneer, et al |
J Comput Aided Mol Des |
Coronavirology| Coronavirologie |
Introduce a fragment-based docking method and test if it reduces requirements on the accuracy of an input receptor
structures relative to non-fragment docking approaches. In this method, small rigid fragments are docked first using AutoDock Vina to generate a large number of favorably docked poses spanning the receptor binding pocket. Then a graph theory maximum clique
algorithm is applied to find combined sets of docked poses of different fragment types onto which the complete ligand can be properly aligned. Then the method is tested for unbound docking with modeled receptor structures for a number of protein–ligand complexes
from different families including the very recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protease. Results suggest that for docking with approximately modeled receptor structures, fragment-based methods can be more effective than common
complete ligand docking approaches. |
|
Sample pooling as a strategy for community monitoring for SARS-CoV-2 |
Sawicki, Rafal, Korona-Glowniak, et al |
Research Square prepub |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Sample pooling strategy was intended to determine the optimal parameters for group testing of pooled specimens for
the detection of SARS-CoV-2 and process them without significant loss of test usability, using standard molecular diagnostic methods. The analysis of 112 specimens determined that 12 pools were positive followed by identification of 6 positive individual specimens
among the 112 tested. Pool testing can detect a single positive sample with Ct value as high as 34. |
|
Genome-scale identification of SARS-CoV-2 and pan-coronavirus host
factor networks |
Schneider, WilliamM, Luna, et al |
bioRxiv |
Coronavirology| Coronavirologie |
In order to develop an extensive compendium of host factors required for infection by SARS-CoV-2 and three seasonal
coronaviruses (HCoV-OC43, HCoV-NL63, and HCoV-229E), investigators performed parallel genome-scale CRISPR knockout screens. Identified an absolute requirement for the VTT-domain containing protein TMEM41B for infection by SARS-CoV-2 and all other coronaviruses. |
|
Schwartz, NG, Moorman, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Transmission |
During July–August 2020, four state health departments and CDC investigated a COVID-19 outbreak that occurred during
a 3-week family gathering of five households in which an adolescent aged 13 years was the index and suspected primary patient; 11 subsequent cases occurred. |
|
|
Management of suspected COVID-19 patients in a low prevalence region |
Scichilone, N, Basile, et al |
Chronic Respiratory Disease |
Healthcare Response | Réponse des soins de santé |
We describe the application of rules and pathways in a regional context with low diffusion of the infection among the
general population in the attempt to provide the best care to respiratory patients with suspected COVID-19. To date, this process has avoided the worst-case scenario of intra-hospital epidemic outbreak. |
|
Seclén, SN, Nunez-Robles, et al |
Diabetes research and clinical practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to investigate the cumulative incidence and mortality of COVID-19 and the prevalence
of comorbidities in regions with different altitude levels ranging from sea level to high altitude. COVID-19 maintained an inverse correlation with higher rates in the coastal regions and lower rates with increasing altitude in the cumulative incidence and
mortality, adjusted for gender and age. The prevalence of diabetes and obesity showed the same inverse correlation trend with altitude but not hypertension. The data in Peru suggests that physiological adaptation in a hypoxic environment at high altitude may
protect persons from the severe impact of acute infection caused by SARS-CoV-2. |
|
|
32979913; Acute Mesenteric Ischemia in a Patient with COVID-19: A Case Report |
Sehhat, S, Talebzadeh, et al |
Archives of Iranian medicine |
Clinical data| Données cliniques |
We report a case of extensive acute mesenteric ischemia associated with SARS-CoV-2 infection confirmed in a patient
hospitalized in Amin Hospital - a COVID-19 referral center in Isfahan University of Medical Sciences, Isfahan, Iran. This case highlights the importance of paying attention to serious and less common or less known clinical manifestations other than fever,
dry cough, dyspnea, and myalgia. |
|
Sethi, A, Sanam, et al |
RSC Advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In the present study, 330 galectin inhibitors were tested against SARS-CoV-2 spike (S) protein with the aid of molecular
docking and molecular dynamics. Finally, the binding free energy and contributing energies were calculated for 2 top scoring ligands by using MM-GBSA method. Among the ligands screened, TD-139, a molecule currently in Phase IIb clinical trials, was found to
be a potential hit. |
|
|
Sha, Z, Chang, et al |
Annals of Palliative Medicine |
Healthcare Response | Réponse des soins de santé |
We sought to study the impact of COVID-19 on lung cancer patients in our center in China. A total of 161 cases of lung
cancer were included. As of April 15, 95 patients had delayed their return visit, and 47 cases were designated as having delayed admission during the epidemic and having to discontinue or delay their regular anticancer treatments. Of these 47 delayed patients,
33 were evaluated for tumor status using a computed tomography scan, 6 of these 33 cases (18.18%) were diagnosed as progressive disease (PD), and 5 cases did not return for visit. |
|
|
32979911; Validity of a Serological Diagnostic Kit for SARS-CoV-2 Available in Iran |
Shamsollahi, HR, Amini, et al |
Archives of Iranian medicine |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
114 positive RT-PCR-diagnosed patients were tested by VivaDiag Kit, a brand of rapid serological kits available in
hospitals in Iran. Test sensitivity was 47.9% for IgM and 47.0% for IgG. There was no difference between IgG and IgM seropositivity except in one case. Specificity was calculated as 99.0% for IgM and of 100.0% for IgG. Sensitivity was higher in men and older
participants. |
|
First
reported death of a postpartum woman due to coronavirus disease 2019 in Nepal: A lesson learnt |
Shrestha, AP, Bhushal, et al |
Kathmandu University Medical Journal |
Clinical data| Données cliniques |
We report the first death of a 29-years-old postpartum woman due to COVID-19 in Nepal who was referred from a rural
health center to Dhulikhel Hospital. On arrival, she was taken to the acute respiratory zone of the emergency department to provide immediate lifesaving procedures. Despite the repeated resuscitative measures, return of spontaneous circulation could not be
achieved. The real time polymerase chain reaction test was positive. Our case report highlights the importance of early clinical suspicion, importance of “safety first” in healthcare settings, and the chain of management in such patients. |
|
32914750; Impact of the COVID-19 pandemic on ophthalmology residency training in Portugal |
Silva, N, Laiginhas, et al |
Acta Medica Portuguesa |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to provide objective and real-life data concerning the impact of the COVID-19 pandemic
on ophthalmology residency training in Portugal. All except one (99%) admitted a change in their routine clinical practice during the pandemic, and most (89%) continued to be engaged in ophthalmology department duties. Twenty-five percent were deployed to
COVID-19 units, which was combined with ophthalmological activities in about half of them (47%). |
|
Sinard, JH |
Academic Pathology |
Healthcare Response | Réponse des soins de santé |
The recent COVID pandemic has had a major effect on anatomic pathology specimen volumes across the country. The effect
of this pandemic on a subspecialty academic practice is presented. We used a data-driven approach to monitor the changing workloads in a granular fashion and dynamically adjust the scheduling of faculty and histology staff accordingly to minimize the number
of people present on-site. At the peak of the pandemic locally, the main hospital in our health system had 450 COVID-positive inpatients. The surgical pathology specimen volume dropped to 13% of the pre-pandemic levels. |
|
|
Singer, JS, Cheng, et al |
Surgery (United States) |
Epidemiology| Épidémiologie |
In this retrospective observational case series evaluating UCLA Health patients enrolled in pre-operative/pre-procedure
protocol COVID-19 RT–PCR testing between April 7, 2020 and May 21, 2020, we determine the prevalence of COVID-19 infection in asymptomatic patients scheduled for surgeries and procedures. Eighteen of 4,751 (0.38%) patients scheduled for upcoming surgeries
and high-risk procedures had abnormal (positive/inconclusive) COVID-19 RT-PCR testing results. Six of 18 patients were confirmed asymptomatic and had positive test results. The prevalence of asymptomatic COVID-19 infection was 0.13%. |
|
|
Singh, B, Dhall, et al |
Global Business Review |
Economics | Économie |
This study examines the impact of the COVID-19 outbreak on the stock markets of G-20 countries. We use an event study
methodology to measure abnormal returns (ARs) and panel data regression to explain the causes of ARs. We find statistically significant negative ARs in the four sub-event windows during the 58 days post the COVID-19 outbreak news release in the international
media. The decrease is a consequence of increased panic in the stock markets resulting from an increased number of COVID-19 positive cases. ARs from day 43 to day 57, indicates the recovery of stock markets after a major stock price correction due to COVID-19.
Additionally, the results of panel data analysis confirm the recovery of stock markets from the negative impact of COVID-19. |
|
|
Singh, Urminder, Hernandez, et al |
Research Square prepub |
Clinical data| Données cliniques |
We undertook a large-scale assessment of differential gene expression between African Americans and European Americans.
We observed widespread differential expression of genes implicated in COVID-19 and integral to epithelial boundary function, inflammation, infection, and reactive oxygen stress. Notably, expression of the little-studied F8A2 gene is up to 40-fold greater in
African Americans. African American gene expression signatures reveal increased number or activity of esophageal glandular cells and lung ACE2-positive basal keratinocytes. |
|
|
Impact of COVID-19 on Patient Behavior to Stroke Symptoms in China |
Song, L, Ouyang, et al |
Cerebrovasc Dis |
Healthcare Response | Réponse des soins de santé |
We wish to highlight how COVID-19 has influenced the behavior of patients with suspected stroke. INTERACT4 is a multicenter,
prospective, randomized, open, blinded outcome assessed, trial of prehospital, ambulance-administered, intensive blood pressure-lowering treatment in patients with FAST-positive presumed acute stroke within 2 h from last known well. This screened eligibility
rate in the Emergency Department of the project lead hospital in Shanghai is much lower than that recorded in the period before the pandemic. The percentage of exceeding the time window among excluded patients during the pandemic is higher than that recorded
in a similar period before the pandemic. These patients indicated that they postponed calling the emergency hotline due to concerns of “getting infected” from being exposed at a “high-risk” hospital, and their first reaction was to wait and hope that the symptom(s)
would mitigate or disappear. |
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Experience in the management of severe COVID-19 patients in an intensive care unit |
Sosa-García, JO, Gutiérrez-Villaseñor, et al |
Cirugia y Cirujanos (English Edition) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this observational, descriptive, longitudinal, and retrospective study was to describe the clinical
characteristics and management of severe COVID-19 patients in Mexico. 56 patients were admitted, of whom 80.3% (n = 45) were males. Mortality rate was 17.8% (n = 10). The characteristics of the critically ill patients in our hospital were mostly elderly and
obese, with the variables of higher SOFA score and acute kidney injury associated with higher mortality. |
|
Sperotto, A, Candoni, et al |
J Med Virol |
Epidemiology| Épidémiologie Immunology | Immunologie |
To improve the SARS-CoV-2 infection screening in our Allogeneic-Stem Cell Transplant (Allo-SCT) outpatient population,
we adopted a triage procedure and a stringent and active surveillance combining two diagnostic tests, an RT-PCR and a rapid serological test. All the 185 RT-PCR nasopharyngeal swabs were negative. Only 1/70 (1.5%) rapid serological test was positive (both
IgG and IgM positive) in an asymptomatic patient 12 months after the unrelated Allo-SCT for a lymphoma. Upon further testing, the infectious disease team concluded this was a false positive rapid serological test. |
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Stoica, CA, Umbreș, et al |
European Societies |
Public Health response| Interventions de santé publique |
The current pandemic has generated many conspiracy theories (CTs). In this paper, we investigate several determinants
of COVID-19 CTs using survey data from Romania. Some of our findings are consistent with those of previous studies on other CTs: low values of social integration, open-mindedness, and analytical thinking predict conspiracy thinking as well as higher levels
of collective narcissism. Other findings run counter to those of prior research on CTs. We hypothesize that this might be due to the specificity of the CTs under scrutiny and related to the Romanian context. |
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COVID-19 and its impact on gynaecologic oncology practice in India-results of a nationwide survey |
Subbian, A, Kaur, et al |
ecancermedicalscience |
Healthcare Response | Réponse des soins de santé |
The COVID-19 pandemic sweeping across the world has caused major disruptions in healthcare delivery and practice. A
survey was conducted to assess the changes in the care of gynaecologic oncology patients in India. There was a significant drop in gynaecologic oncology patients attending government hospitals as compared to the non-government sector. The drop was not significantly
different in areas having low versus high COVID-19 case volumes. |
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EDNA-COVID: A Large-Scale Covid-19 Dataset Collected with the EDNA Streaming Toolkit |
Suprem, Abhijit, Pu, et al |
arXiv |
Public Health response| Interventions de santé publique |
We present (i) the EDNA streaming toolkit for consuming and processing streaming data, and (ii) EDNA-Covid, a multilingual,
large-scale dataset of coronavirus-related tweets collected with EDNA since January 25, 2020. EDNA-Covid includes, at time of this publication, over 600M tweets from around the world in over 10 languages. Conversations about Wuhan peak in the first few weeks
and then decline, signifying the shift in conversations towards the disease itself. More recently, conversations about the pandemic itself have taken precedence over conversations about the disease, as pandemic and mask see increased weight in the stream. |
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Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer’s
disease brain |
Suzuki, YuichiroJ, Ding, et al |
bioRxiv |
Clinical data| Données cliniques |
The present study demonstrates that the protein expression level of ACE2 is upregulated in the brain of Alzheimer’s
disease patients. The increased ACE2 expression is not age-dependent, suggesting the direct relationship between Alzheimer’s disease and the ACE2 expression. Thus, these results warrant monitoring Alzheimer’s disease patients with COVID-19 carefully for the
possible higher viral load in the brain and long-term adverse neurological consequences. |
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Severity assessment of COVID-19 using CT image features and laboratory indices |
Tang, Z, Zhao, et al |
Phys Med Biol |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The coronavirus disease 2019 (COVID-19) is now a global pandemic. Tens of millions of people have been confirmed infection,
and more people are suspected. Chest computed tomography (CT) is recognized as an important tool for COVID-19 severity assessment. As the number of chest CT images increase rapidly, manual severity assessment becomes a labor-intensive task, delaying appropriate
isolation and treatment. In this paper, a study of automatic severity assessment for COVID-19 is presented. Specifically, chest CT images of 118 patients (age 46.5±16.5 years, 64 male and 54 female) with confirmed COVID-19 infection are used, from which 63
quantitative features and 110 Radiomics features are derived. Besides the chest CT image features, 36 laboratory indices of each patient are also used, which can provide complementary information from a different view. A random forest (RF) model is trained
to assess the severity (non-severe or severe) according to the chest CT image features and laboratory indices. Importance of each chest CT image feature and laboratory index, which reflects the correlation to the severity of COVID-19, is also calculated from
the RF model. Using three-fold cross-validation, the RF model shows promising results: 0.910 (true positive ratio), 0.858 (true negative ratio) and 0.890 (accuracy), along with AUC of 0.98. Moreover, several chest CT image features and laboratory indices are
found to be important to COVID-19 severity, which could be valuable for the clinical diagnosis of COVID-19. |
|
SARS-CoV-2 historical global testing and genomic variability |
Tannous, Halim, Akiki, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
The world has been dealing with the COVID-19 pandemic since December 2019 and a lot of effort has focused on tracking
the spread of the virus by gathering information regarding testing statistics and generating viral genomic sequences. Unfortunately, there is neither a single comprehensive resource with global historical testing data nor a centralized database with summary
statistics of the identified genomic variants. We merged different pre-aggregated historical testing data and complemented them with our manually extracted ones, which consist of 6852 historical test statistics from 76 countries/states unreported in any other
dataset, at the date of submission, making our dataset the most comprehensive to date. We also analyzed all publicly deposited SARS-CoV-2 genomic sequences in GISAID and annotated their variants. Both datasets can be accessed through our interactive dashboard
which also provides important insights on different outbreak trends across countries and states. The dashboard is available at https://bioinfo.lau.edu.lb/gkhazen/covid19. A daily updated version of the datasets can be downloaded from github.com/KhazenLab/covid19-data. |
|
Team, Covid- National Incident Room Surveillance |
Communicable diseases intelligence (2018) |
Epidemiology| Épidémiologie Surveillance |
Cumulatively to 13 September there have been 26,753 case notifications and 674 deaths. The number of new cases reported
nationally this fortnight was 764, a 61% decrease from the previous fortnight. In Victoria, 97% of cases (621) were locally acquired and were mostly reported from residential aged care facilities; and 3% of cases (19) were reported as under investigation at
the date of extract this reporting period. Excluding Victoria, 124 cases were reported nationally, 32% (40) were overseas acquired; 65% (81) were locally acquired. |
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Infodemic: What physician leaders learned during the COVID-19 outbreak: A qualitative study |
Tham, KY, Lu, et al |
BMJ Leader |
Healthcare Response | Réponse des soins de santé |
While instant messaging and social media provided abundant and powerful sources of information during the COVID-19
pandemic, the infodemic-An overabundance of information, some of which is inaccurate-has also complicated the tasks of crisis leadership. A qualitative study was undertaken, using semistructured interviews with physician leaders in the hospital dealing with
majority of Singapore's COVID-19 cases. Participants were asked about how they used digital communication tools in their leadership roles before and during the outbreak, and their reflections on the use of these tools. While these tools were useful for rapid
collective sense-making, meaning-making was the most challenging because information was posted by others who were faster, competed with their ability to create nuanced versions of a coherent narrative for stakeholders. Leaders also shared the need to balance
their relationship with their smartphone and use digital tools to communicate purpose and meaning to and with their staff when face-to-face meetings are not possible. |
|
Thomas, J, Barbato, et al |
Religions |
Public Health response| Interventions de santé publique |
This study explored positive religious coping among the Muslim and Christian residents of the United Arab Emirates
(UAE) during the early stages of the national response to the COVID-19 pandemic. Participants (N = 543) completed an online survey assessing religious coping in response to the pandemic, along with symptom measures of depression, anxiety and history of psychological
disorder. Muslims (N = 339) reported significantly higher levels of positive religious coping compared to their Christian counterparts (N = 204). Across the whole sample, positive religious coping was inversely related to having a history of psychological
disorders. Among the Muslim cohort, positive religious coping was inversely related to depressive symptoms and having a history of psychological disorders. |
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Impact of COVID-19 Related Policy Changes on Buprenorphine Dispensing in Texas |
Thornton, JD, Varisco, et al |
J Addict Med |
Public Health response| Interventions de santé publique |
Measured the change in the daily number of patients receiving buprenorphine and buprenorphine prescribers during the
early phase of the COVID-19 (SARS-CoV-2) pandemic in Texas. Counts of the number of patients filling and number of providers prescribing buprenorphine were calculated for each weekday between November 4, 2019 and May 12, 2020. The rate of change of daily
buprenorphine prescriptions (β = -1.75, 95% CI = -5.8-2.34) and prescribers (β = -0.32, 95% CI = -1.47-0.82) declined insignificantly during the COVID-19 period compared to the baseline. |
|
Tiwari, Vaibhav, Tandon, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The COVID-19 pandemic caused by SARS-CoV-2 is in immediate need of an effective antidote. Although the Spike glycoprotein
(SgP) of SARS-CoV-2 has been shown to bind to heparins, the structural features of this interaction, the role of a plausible heparan sulfate proteoglycan (HSPG) receptor, and the antagonism of this pathway through small molecules remain unaddressed. Using
an in vitro cellular assay, we demonstrate HSPGs modified by the 3-O-sulfotransferase isoform-3, but not isoform-5, preferentially increased SgP-mediated cell-to-cell fusion in comparison to control, unmodified, wild-type HSPGs. Computational studies support
preferential recognition of the receptor-binding domain of SgP by 3-O-sulfated HS sequences. Competition with either fondaparinux, a 3-O-sulfated HS-binding oligopeptide, or a synthetic, non-sugar small molecule, blocked SgP-mediated cell-to-cell fusion. Finally,
the synthetic, sulfated molecule inhibited fusion of GFP-tagged pseudo SARS-CoV-2 with human 293T cells with sub-micromolar potency. Overall, overexpression of 3-O-sulfated HSPGs contribute to fusion of SARS-CoV-2, which could be effectively antagonized by
a synthetic, small molecule. |
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|
Torkian, P, Rajebi, et al |
Clinical imaging |
Clinical data| Données cliniques |
In this study, we aimed to review and depict the common MRI features of COVID-19 pneumonia in our laboratory confirmed
case series. Eight laboratory confirmed COVID-19 patients who presented to our outpatient imaging clinic underwent chest CT and, once various features of COVID-19 pneumonia were identified, a dedicated multisequence chest MRI was performed on the same day.
Five cases had typical CT features with ground glass opacities and consolidations, readily visible on different MRI sequences. Three cases had indeterminate or atypical features which were also easily seen on MRI. |
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Decrease in gynecological cancer diagnoses during the COVID-19 pandemic: an Austrian perspective |
Tsibulak, I, Reiser, et al |
Int J Gynecol Cancer |
Healthcare Response | Réponse des soins de santé |
To assess the impact of the COVID-19 pandemic on the rate of newly diagnosed gynecological and breast cancers in Austria.
Data of 2077 patients from 18 centers in Austria with newly diagnosed gynecological or breast cancer between January and May 2019 and January and May 2020 were collected. Our results showed a slight increase of newly diagnosed cancers in January and February
2020 as compared with 2019 (+2 and +35%, respectively) and a strong decline in newly diagnosed tumors since the lockdown: -24% in March 2020 versus March 2019, -49% in April 2020 versus April 2019, -49% in May 2020 versus May 2019. Two-thirds of patients diagnosed
during the pandemic presented with tumor-specific symptoms compared with less than 50% before the pandemic. Moreover, almost 50% of patients in 2020 had no co-morbidities compared with 35% in 2019. Patients, who already had a malignant disease, were rarely
diagnosed with a new cancer in 2020 as compared with 2019 (11% vs 6%). |
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COVID-19 pandemic: Solid waste and environmental impacts in Brazil |
Urban, RC, Nakada, et al |
Science of the Total Environment |
Public Health response| Interventions de santé publique |
The World Health Organization has recently declared South America the new epicenter of the COVID-19 pandemic, as Brazil
has become one of the most affected countries. Besides public health and economic impacts, social isolation has also caused indirect environmental effects. The aim of this study was to assess environmental impacts caused by shifts on solid waste production
and management due to the COVID-19 pandemic in Brazil. We have analyzed data from 30 cities, representing a population of more than 53.8 million people (25.4% of the Brazilian population). Unexpectedly, solid waste production in the main cities in Brazil has
decreased during the social isolation period, possibly because of reduced activity in commercial areas. The latest data on solid waste in Brazil have revealed that more than 35% of medical waste has not been treated properly. Furthermore, improper disposal
of facemasks has been reported in several cities and may increase the risk for COVID-19 spread. The suspension of recycling programs has hindered natural resources from being saved, with emphasis on 24,076 MWh of electric power and 185,929 m3 of potable water
– respectively enough to supply 152,475 households and 40,010 people, over a month. Furthermore, total sale price for recyclable materials during the suspension of recycling programs reaches more than 781 thousand dollars, being these materials disposed in
landfills – demanding an extra volume of 19,000 m3 – reducing landfill lifespan, and hence causing a double loss: economic and environmental. © 2020 Elsevier B.V. |
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Vakulenko, V, Khodachek, et al |
Journal of Public Budgeting, Accounting and Financial Management |
Economics | Économie |
Compared Russian and Ukrainian central governments' reaction to the pandemic, reflected in extraordinary budgetary
allocations and to provide our understanding of how those allocations can be attributed to the two countries’ different social, economic and political contexts. The findings showed that uncertainty caused by COVID-19 and the corresponding lockdown policies
in Russia and Ukraine have produced two divergent patterns of budgetary allocations: step-by-step budgetary allocations in Russia vs one emergency budget decision in Ukraine. |
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Varela-Santos, S, Melin, et al |
Information Sciences |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Since the recent challenge that humanity is facing against COVID-19, several initiatives have been put forward with
the goal of creating measures to help control the spread of the pandemic. In this paper we present a series of experiments using supervised learning models in order to perform an accurate classification on datasets consisting of medical images from COVID-19
patients and medical images of several other related diseases affecting the lungs. This work represents an initial experimentation using image texture feature descriptors, feed-forward and convolutional neural networks on newly created databases with COVID-19
images. The goal was setting a baseline for the future development of a system capable of automatically detecting the COVID-19 disease based on its manifestation on chest X-rays and computerized tomography images of the lungs. © 2020 Elsevier Inc. |
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Host – virus – drug interactions as determinants of COVID-19’s phenotypes: A data-driven hypothesis |
Vavougios, GD |
Medical hypotheses |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
There is a growing body of evidence on the significance of interactions between comorbidities, their treatments and
COVID-19 clinical phenotypes. The hypothesis explored herein is that pharmaceutical compounds currently in use are affecting COVID-19 susceptibility and phenotypes by overlapping transcriptional networks. Using two distinct SARS-CoV-2 – host interactomes,
gene set enrichment analysis is used to discover compounds and assorted gene signatures derived from SARS-CoV-2 interactomes. Micronutrients, antiplatelets, ACE2 inhibitors, NSAIDs, corticosteroids and tyrosine kinase inhibitors are among the compounds discovered.
Considering the implication of their associated comorbidities such as diabetes and cardiovascular disease that are associated with severe COVID-19, this study outlines the need to consider specific compounds as modulators of the observed COVID-19 spectrum.
Furthermore, given that micronutrient trafficking may be targeted by viral processes, and display synergism with other enriched compounds, such as statins, studies assessing their levels prior and during infection are more than warranted. © 2020 |
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Venkatakrishnan, AJ, Kayal, et al |
Cell Death Discovery |
Coronavirology| Coronavirologie |
The hand of molecular mimicry in shaping SARS-CoV-2 evolution and immune evasion remains to be deciphered. Here, we
report 33 distinct 8-mer/9-mer peptides that are identical between SARS-CoV-2 and the human reference proteome. We benchmark this observation against other viral–human 8-mer/9-mer peptide identity, which suggests generally similar extents of molecular mimicry
for SARS-CoV-2 and many other human viruses. Interestingly, 20 novel human peptides mimicked by SARS-CoV-2 have not been observed in any previous coronavirus strains (HCoV, SARS-CoV, and MERS). Furthermore, four of the human 8-mer/9-mer peptides mimicked by
SARS-CoV-2 map onto HLA-B*40:01, HLA-B*40:02, and HLA-B*35:01 binding peptides from human PAM, ANXA7, PGD, and ALOX5AP proteins. This mimicry of multiple human proteins by SARS-CoV-2 is made salient by single-cell RNA-seq (scRNA-seq) analysis that shows the
targeted genes significantly expressed in human lungs and arteries; tissues implicated in COVID-19 pathogenesis. Finally, HLA-A*03 restricted 8-mer peptides are found to be shared broadly by human and coronaviridae helicases in functional hotspots, with potential
implications for nucleic acid unwinding upon initial infection. This study presents the first scan of human peptide mimicry by SARS-CoV-2, and via its benchmarking against human–viral mimicry more broadly, presents a computational framework for follow-up studies
to assay how evolutionary tinkering may relate to zoonosis and herd immunity. © 2020, The Author(s). |
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32916352; Deployment of Neurosurgeons at the Warfront Against Coronavirus Disease of 2019 (COVID-19) |
Venkataram, T, Goyal, et al |
World Neurosurgery |
Clinical data| Données cliniques |
Two physicians from the Department of Neurosurgery who were deployed in the COVID-19 testing ward between April 25
and May 31, 2020 share their experience. A prospective observational study was conducted including all those who were admitted in this ward. During the study period, there were 256 admissions in the ward, of whom 148 (92 male, 56 female) were patients and
108 were patients’ attendants/relatives. Most patients were admitted under the departments of internal medicine (33, 22.3%) and general surgery (19, 12.8%). Of 148 patients, 46 (31.1%) were admitted as they were planned for a surgery/intervention. Among 148
patients, 29 (19.6%) had history of travel to or were residents of a red zone, 4 (2.7%) had history of contact with a confirmed case of COVID-19, whereas 6 (4.1%) were health care workers. One hundred four patients (70.2%) showed no COVID-19–related symptoms.
Thirty-four patients (22.9%) had associated comorbid conditions. Eight patients (5 male, 3 female) with mean age of 37.6 years (range 4–69 years) tested positive for COVID-19. |
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Verdery, AM, Newmyer, et al |
Gerontologist |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Drawing on surveys of older adults from 42 countries and estimated case fatality ratios by age and preexisting health
conditions, we document and compare national profiles of COVID-19 mortality risks among older adults. We develop two measures of national risk profiles: one based on age structures and another based on distributions of preexisting health conditions. National
profiles of COVID-19 mortality risk based on age structure and preexisting health conditions are moderately uncorrelated, capturing different aspects of risk. Both types of national risk profiles correlate meaningfully with countries' COVID-19 mortality experiences
to date. |
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|
Characteristics of Hospitalized Children
With SARS-CoV-2 in the New York City Metropolitan Area |
Verma, S, Lumba, et al |
Hosp Pediatr |
Clinical data| Données cliniques |
Describe the characteristics of hospitalized children with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
in New York City metropolitan area. This was a multicenter, retrospective cohort study at four hospitals comprising 82 hospitalized children (0-21 years) who tested positive for SARS-CoV-2 after symptoms and risk screening between March 1 and May 10, 2020.
Twenty-three (28%) patients required critical care. Twenty-nine (35%) patients requiring respiratory support with 9% needing mechanical ventilation and one required extracorporeal support. All patients survived to discharge. Children with any comorbidity were
more likely to require critical care (70% vs. 37%), with obesity as the most common risk factor for critical care (63% vs. 28%). Children with asthma were more likely to receive respiratory support (28% vs. 8%), with no difference in need for critical care.
Children admitted to critical care had higher rates of renal dysfunction at presentation (43% vs. 10%). |
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Vong, S, Kakkar, et al |
WHO South-East Asia journal of public health |
Epidemiology| Épidémiologie Surveillance |
In an effort to monitor coronavirus disease 2019 (COVID-19), many countries have been calculating the ratio of cases
confirmed to tests performed (test positivity ratio - TPR). While inferior to sentinel surveillance, TPR has the benefit of being easily calculated using readily available data; however, interpreting TPR and its trends can be complex because both the numerator
and the denominator are constantly changing. We describe a three-step process where the ratio of relative increase in cases to relative increase in tests is accounted for in an adjusted TPR. This adjusted value more appropriately reflects the case number and
factors out the effect of changes in the number of tests done. Unadjusted and adjusted TPRs are then assessed step-wise with reference to the epidemic curve and the cumulative numbers of cases and tests. Use of this three-step analysis and its potential use
in guiding public health interventions are demonstrated for selected countries and subnational areas of the World Health Organization South-East Asia Region, together with the Republic of Korea as a reference. To date, application of the three-step analysis
to data from countries of the region has signalled potential inadequacies of testing strategies. Further work is needed on approaches to support countries where testing capacity is likely to remain constrained. One example would be enumeration of the average
number of tests needed to detect one COVID-19 case, which could be stratified by factors such as location and population. Such data would allow evidence-informed strategies that best balance the highest detection rate with the prevailing testing capacity. |
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Epidemiological characteristics and the entire evolution of coronavirus disease 2019 in Wuhan,
China |
Wang, D, Cai, et al |
Respir Res |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Describe the epidemiological characteristics and the entire evolution of COVID-19 in Wuhan, and to evaluate the effect
of non-pharmaceutical intervention by the government. A total of 49,973 confirmed cases were reported until Mar 18, 2020 in Wuhan. Among whom, 2496 cases died and the overall mortality was 5.0%. Most confirmed cases (25,619, 51.3%) occurred during Jan 23 to
Feb 4, with a spike on Feb 1 (new cases, 3374). The number of daily new cases started to decrease steadily on Feb 19 (new cases, 301) and decreased greatly on Mar 1 (new cases, 57). However, the mortality and the proportion of severe and critical cases has
been decreasing over time, with the lowest of 2.0 and 10.1% during Feb 16 to Mar 18, 2020, respectively. The percentage of severe and critical cases among all cases was 19.6%, and the percentage of critical and dead cases aged over 60 was 70.1 and 82.0%, respectively. |
|
Wang, H, Miao, et al |
Journal of Environmental Sciences (China) |
Public health interventions*| Interventions de santé publique |
To control the spread of COVID-19, rigorous restrictions have been implemented in China, resulting in a great reduction
in pollutant emissions. In this study, we evaluated the air quality in the Yangtze River Delta during the COVID-19 lockdown period using satellite and ground-based data, including particle matter (PM), trace gases, water-soluble ions (WSIs) and black carbon
(BC). We found that the impacts of lockdown policy on air quality cannot be accurately assessed using MODIS aerosol optical depth (AOD) data, whereas the tropospheric nitrogen dioxide (NO2) vertical column density can well reflect the influences of these restrictions
on human activities. Compared to the pre-COVID period, the PM2.5, PM10, NO2, carbon monoxide (CO), BC and WSIs during the lockdown in Suzhou were observed to decrease by 37.2%, 38.3%, 64.5%, 26.1%, 53.3% and 58.6%, respectively, while the sulfur dioxide (SO2)
and ozone (O3) increased by 1.5% and 104.7%. The WSIs ranked in the order of NO3− > NH4+ > SO42- > Cl− > Ca2+ > K+ > Mg2+ > Na+ during the lockdown period. By comparisons with the ion concentrations during the pre-COVID period, we found that the ions NO3−,
NH4+, SO42−, Cl−, Ca2+, K+ and Na+ decreased by 66.3%, 48.8%, 52.9%, 56.9%, 57.9% and 76.3%, respectively, during the lockdown, in contrast to Mg2+, which increased by 30.2%. The lockdown policy was found to have great impacts on the diurnal variations of
Cl−, SO42−, Na+ and Ca2+. © 2020 |
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32985162; Qualitative study on working experience of COVID-19 care nurses |
Wang, J, He, et al |
Zhejiang da xue xue bao.Yi xue ban = Journal of Zhejiang University.Medical sciences |
Healthcare Response | Réponse des soins de santé |
Studied the working experience of COVID-19 care nurses. Twenty two nurses taking care of COVID-19 patients were interviewed
by means of descriptive phenomenology. Two main themes were extracted: one is the positive feelings of nurses, including the sense of professional mission and pride, the sense of achievement and happiness, the improvement of self-worth and ability, the powerful
support system and the power of role models; the other is the negative experience of nurses, including the worry and anxiety at work, the lack of experience and trust, the difficulty of work, and the inconvenience of isolating life. |
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Chest CT findings in a pregnant woman in the second trimester with COVID-19 pneumonia |
Wang, J, Shu, et al |
Clinical imaging |
Clinical data| Données cliniques |
We report a case of pregnant woman with COVID-19 pneumonia in the second trimester. Clinical and imaging features of
the patient were similar to that reported in the literatures for both perinatal patients and non-pregnant patients. |
|
Wang, KW, Gao, et al |
One Health |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
Wuhan established Fangcang Shelter hospitals as a One Health approach for responding to and containing the COVID-19
outbreak by isolating and caring for mild-to-moderate cases. This study performed an interrupted time series analysis to compare the number of new confirmed cases of COVID-19 before and after the operation of Fangcang Shelter hospitals. Compared with the number
of cases noted 20 days before the use of Fangcang Shelter hospitals, a sustained reduction in the number of confirmed cases (trend change, −125.57; P < 0.0001) was noted 41 days after the use of the hospitals. Immediate-level changes were observed for confirmed
cases (level change, 725.97; P = 0.025). These changes led to an estimated 5148 fewer confirmed cases (P < 0.0001). According to the mean confirmed cases of 395.71 per day before the intervention, we estimated that Wuhan had advanced the terminal phase of
COVID-19 by 13 days. Furthermore, immediately after introduction of Fangcang Shelter Hospitals on February 5, the reproduction number dropped rapidly, from a pre-introduction rate of 4.0 to 2.0. The Fangcang Shelter hospitals most likely reversed the epidemic
trend of COVID-19 while a containment strategy was implemented in Wuhan. |
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Prolonged prothrombin time at admission predicts poor clinical outcome in COVID-19 patients |
Wang, L, He, et al |
World Journal of Clinical Cases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to investigate the abnormalities of coagulation parameters in the patients with COVID-19 and their prognostic
values. Consecutive patients admitted in the isolation ward of Renmin Hospital of Wuhan University from January 31 to February 5, 2020 with confirmed COVID-19 were included. The primary outcomes were death and survival as of March 11. The total number of patients
with confirmed COVID-19 who were enrolled was 213. Fifty-one patients were critical (23.9%), 79 patients were severe (37.1%) and 83 patients were moderate (39%). As of March 11, 2020, 99 patients were discharged (46.5%), 79 patients (37.1%) stayed in the hospital
and 35 patients (16.2%) died. Median time to death was 6 (4-8) d, while median hospital stay was 32 (22-36) d in survivors (P < 0.001). More men (P = 0.002) and elderly patients (P < 0.001) were found in the group of those who died. The respiration rate at
admission was higher in the group of those who died (P < 0.001). The incidences of hypertension (P = 0.028), cerebrovascular disease (P < 0.001), chronic kidney disease (P = 0.02) and chronic obstructive pulmonary disease (P < 0.001) were higher in the group
of those who died. Platelet count was decreased in the group of those who died (P = 0.002) whereas prothrombin time (P < 0.001), activated partial thromboplastin time (P = 0.033), concentration of D-dimer (P < 0.001) and fibrin degradation products (P < 0.001)
were increased in the group of those who died. Prothrombin time odds ratio (OR): 2.19, P = 0.004], respiration rate (OR: 1.223, P < 0.001), age (OR: 1.074, P < 0.001) and fibrin degradation products concentration (OR: 1.02, P = 0.014) were predictors of death.
The survival rate was significantly lower in patients with prolonged prothrombin time compare to those with normal prothrombin time (P < 0.001). Prothrombin time, concentration of fibrin degradation products, respiration rate and age were predictive factors
for clinical outcomes of COVID-19 patients. |
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Epidemiology and clinical characteristics of 43 COVID-19 patients in Weifang, China |
Wang, Q, Zheng, et al |
Annals of Palliative Medicine |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
The demographic data of 43 COVID-19 patients identified in Weifang, China were used to investigate whether they had
traveled to epidemic areas and whether they had close contact with confirmed cases. On admission, patients’ symptoms and results of laboratory tests and imaging were analyzed. Among the 43 COVID-19 patients., including 9 third generation infected cases, 16
(37.2%) were imported, who infected the rest. A “super spreader”, Mr. Zhang made it necessary to quarantine 69 medical personnel. Mr. Zhang directly infected six individuals who, in turn, infected another six individuals. Another patient, Mr. Wang, spread
the infection to his five family members at a family gathering. Subsequently, the daughter infected her husband. The most common COVID-19 symptoms were fever, weakness, dry cough, and cough sputum. In most patients, white blood cell counts were not elevated
and lymphocyte counts were decreased. Elevated C-reactive protein and serum amyloid A protein (SAA) levels were commonly observed. There was no death among the patients or infection among the medical staff. |
|
Spatial-temporal Analysis of COVID-19's Impact on Human Mobility: the Case of the United States |
Wang, Songhe, Wei, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public Health response| Interventions
de santé publique |
In this paper, we study the impact of COVID-19 on human mobility patterns at the state level within the United States.
From the temporal perspective, we find that the change of mobility patterns does not necessarily correlate with government policies and guidelines, but is more related to people's awareness of the pandemic, which is reflected by the search data from Google
Trends. Our results show that it takes on average 14 days for the mobility patterns to adjust to the new situation. From the spatial perspective, we conduct a state-level network analysis and clustering using the mobility data from Multiscale Dynamic Human
Mobility Flow Dataset. As a result, we find that 1) states in the same cluster have shorter geographical distances; 2) a 14-day delay again is found between the time when the largest number of clusters appears and the peak of Coronavirus-related search queries
on Google Trends; and 3) a major reduction in other network flow properties, namely degree, closeness, and betweenness, of all states from the week of March 2 to the week of April 6 (the week of the largest number of clusters). |
|
Wang, W, Xu, et al |
Zhejiang da xue xue bao.Yi xue ban = Journal of Zhejiang University.Medical sciences |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
We aimed to analyze the usage of mental health assistance hotline during COVID-19 in Zhejiang province from January
25th to February 29th 2020, and summarize the characteristics of the demand for mental health services and the dynamic changes of public mental health status during COVID-19 pandemic. In a total of 13 746 calls, 8978 were related to pandemic, among which 12.59%(1130/8978)
were about medical issues, 26.50%(2379/8978) were about mental health, 27.18%(2440/8978) were about information regarding the pandemic and 33.74%(3029/8978) were about other pandemic related issues. Pandemic situation, relevant policy release, frequency of
advertising campaigns were predictors of the number of calls per day during the pandemic (P<0.05 or P<0.01). Finally 181 callers accepted telephone follow-up. Among them, 51.38%(93/181) of the callers thought that the waiting time was too long, 33.15%(60/181)
of the callers thought that the call time was insufficient, 80.66%(146/181) of callers believed that the hotline could partially or completely resolve their concerns, and 39.23%(71/181) of the callers said the operator proposed to end the call. The changes
of the number and content of the mental health assistance hotline calls reflected that the public mental health status experienced four stages during the pandemic: confusion, panic, boredom, and adjustment. The specialized mental health assistance hotlines
should be further strengthened, and the efficiency should be improved. |
|
|
Wang, Y, Chen, et al |
Eur J Pharmacol |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Previously we reported our hypothesis that the antiviral drugs with high lung distributions might benefit COVID-19
patients by reducing viral loads. So far, chloroquine, lopinavir, hydroxychloroquine, azithromycin, favipiravir, ribavirin, darunavir, remdesivir, and umifenovir have been tested in COVID-19 clinical trials. Here we validated our hypothesis by comparing the
pharmacokinetics profiles of these drugs and their capabilities of reducing viral load in clinical trials. According to bulk RNA and single cell RNA sequencing analysis, we found that high expression of both angiotensin converting enzyme 2 (ACE2) and transmembrane
Serine Protease 2 (TMPRSS2) makes the lung and intestine vulnerable to SARS-CoV-2. Hydroxychloroquine, chloroquine, and favipiravir, which were highly distributed to the lung, were reported to reduce viral loads in respiratory tract of COVID-19 patients. Conversely,
drugs with poor lung distributions, including lopinavir/ritonavir, umifenovir and remdesivir, were insufficient to inhibit viral replication. Lopinavir/ritonavir might inhibit SARS-CoV-2 in the GI tract according to their distribution profiles. |
|
|
Wang, Y, Xu, et al |
Infection and Drug Resistance |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The aim of this study is to apply the advanced error-trend-seasonal (ETS) framework to forecast the prevalence and
mortality series of COVID-19 in the USA, the UK, Russia, and India, and the predictive performance of the ETS framework was compared with the most frequently used autoregressive integrated moving average (ARIMA) model. The prevalence and mortality data of
COVID-19 in the USA, the UK, Russia, and India between 20 February 2020 and 15 May 2020 were extracted from the WHO website. Then, the data subsamples between 20 February 2020 and 3 May 2020 were treated as the training horizon, and the others were used as
the testing horizon to construct the ARIMA models and the ETS models. Based on the model evaluation criteria, the ARIMA (0,2,1) and ETS (M,MD,N), sparse coefficient ARIMA (0,2,(1,6)) and ETS (A,AD,M), ARIMA (1,1,1) and ETS (A,MD, A), together with ARIMA (2,2,1)
and ETS (A,M,A) specifications were identified as the preferred ARIMA and ETS models for the prevalence data in the USA, the UK, Russia, and India, respectively; the ARIMA (0,2,1) and ETS (M,A,M), ARIMA (0,2,1) and ETS (M,A, N), ARIMA (0,2,1) and ETS (A,A,N),
coupled with ARIMA (0,2,2) and ETS (M,M,N) specifications were selected as the optimal ARIMA and ETS models for the mortality data in these four countries, respectively. Among these best-fitting models, the ETS models produced smaller forecasting error rates
than the ARIMA models in all the datasets. The ETS framework can be used to nowcast and forecast the long-term temporal trends of the COVID-19 prevalence and mortality in the USA, the UK, Russia, and India, and which provides a notable performance improvement
over the most frequently used ARIMA model. |
|
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Rapid Transition of a PICU Space and Staff to Adult Coronavirus Disease 2019 ICU Care |
Wasserman, E, Toal, et al |
Pediatr Crit Care Med |
Healthcare Response | Réponse des soins de santé |
Within the context of the institution's comprehensive effort to centralize and systematize care for adults with severe
coronavirus disease 2019 disease, the PICU was transitioned to an adult coronavirus disease 2019 critical care unit. Nurses and physicians underwent just-in-time training over 3 days and 2 weeks, respectively. Medical ICU physicians and nurses provided oversight
for care and designated hospital-based teams were available for procedures and common adult emergencies. Over a 7-week period, the PICU cared for 60 adults with coronavirus disease 2019-related critical illness. Fifty-three required intubation and mechanical
ventilation for a median of 18 days. Eighteen required renal replacement therapy and 17 died. |
|
Weber, S, Ramirez, et al |
Virus research |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
By analyzing sequence data deposited between December 2019 and end of May 2020, we have compared nucleotide sequences
of 570 SARS-CoV-2 genomes from China, Europe, the US, and India to the sequence of the Wuhan isolate. During worldwide spreading among human populations, at least 10 distinct hotspot mutations had been selected and found in up to > 80 % of viral genomes. Many
of these mutations led to amino acid exchanges in replication-relevant viral proteins. Mutations in the SARS-CoV-2 genome would also impinge upon the secondary structure of the viral RNA molecule and its repertoire of interactions with essential cellular and
viral proteins. The increasing frequency of SARS-CoV-2 mutation hotspots might select for dangerous viral pathogens. Alternatively, in a 29.900 nucleotide-genome, there might be a limit to the number of mutable and selectable sites which, when exhausted, could
prove disadvantageous to viral survival. The speed, at which novel SARS-CoV-2 mutants are selected and dispersed around the world, could pose problems for the development of vaccines and therapeutics. |
|
|
Clinical characteristics and manifestations in older patients with COVID-19 |
Wei, C, Liu, et al |
BMC Geriatr |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective study, 566 patients with confirmed COVID-19 were enrolled to investigate the clinical characteristics
and manifestations of older patients. Among the 566 patients (median age, 61.5 years) with COVID-19, 267 (47.2%) patients were male and 307 (54.2%) were elderly. Older patients, especially the oldest-old patients were more likely to exhibit significant systemic
inflammation, pulmonary and extrapulmonary organ damage and a higher mortality. Advanced age, lymphopenia, ARDS, acute cardiac injury, heart failure and skeletal muscle injury were independent predictors of death in older patients with COVID-19 and glucocorticoids
should be carefully administered in older patients. |
|
Westblade, LF, Brar, et al |
Cancer Cell |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Patients with cancer may be at increased risk of severe coronavirus disease 2019 (COVID-19), but the role of viral
load on this risk is unknown. We measured SARS-CoV-2 viral load using cycle threshold (CT) values from reverse-transcription polymerase chain reaction assays applied to nasopharyngeal swab specimens in 100 patients with cancer and 2,914 without cancer who
were admitted to three New York City hospitals. Overall, the in-hospital mortality rate was 38.8% among patients with a high viral load, 24.1% among patients with a medium viral load, and 15.3% among patients with a low viral load (p < 0.001). Similar findings
were observed in patients with cancer (high, 45.2% mortality; medium, 28.0%; low, 12.1%; p = 0.008). Patients with hematologic malignancies had higher median viral loads (CT = 25.0) than patients without cancer (CT = 29.2; p = 0.0039). SARS-CoV-2 viral load
results may offer vital prognostic information for patients with and without cancer who are hospitalized with COVID-19. |
|
|
Xing, W, Liu, et al |
Engineering |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We present a high-throughput, multi-index nucleic acid isothermal amplification analyzer (RTisochip™-W) employing a
centrifugal microfluidic chip to detect 19 common respiratory viruses, including SARS-CoV-2, from 16 samples in a single run within 90 min. The limits of detection of all the viruses analyzed by the RTisochip™-W system were equal to or less than 50 copies
per microliter, which is comparable to those of conventional reverse-transcription polymerase chain reaction. We also demonstrate that the RTisochip™-W system possesses the advantages of good repeatability, strong robustness, and high specificity. Finally,
we analyzed 201 cases of preclinical samples, 14 cases of COVID-19-positive samples, 25 cases of clinically diagnosed samples, and 614 cases of clinical samples from patients or suspected patients with respiratory tract infections using the RTisochip™-W system.
The test results matched the referenced results well and reflected the epidemic characteristics of the respiratory infectious diseases. The coincidence rate of the RTisochip™-W with the referenced kits was 98.15% for the detection of SARS-CoV-2. Based on these
extensive trials, we believe that the RTisochip™-W system provides a powerful platform for fighting the COVID-19 pandemic. |
|
|
Xiong, Bin, Qin, et al |
Research Square prepub |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We conducted a retrospective analysis of the difference in several outcomes between patients with severe COVID-19 who
received corticosteroid therapy and patients with severe COVID-19 who did not receive corticosteroid therapy. Seventy-five patients were included in this study; 47 patients were in the corticosteroid group and 28 patients were in the non-corticosteroid group.
There were no differences between the two groups in the total length of hospital stay (LOS), the length of ICU stay, high-flow oxygen days, non-invasive ventilator days, invasive ventilation days, and mortality rate. Total lesion volume ratio, consolidation
volume ratio and GGO volume ratio in the corticosteroid group decreased significantly on day 14, while those in the non-corticosteroid group did not show a significant decrease. Our results show that adjunctive corticosteroid use did not significantly improve
clinical outcomes in severe COVID-19 patients, but might promote the absorption of pulmonary lesions. Larger multicenter randomized controlled studies may be needed to confirm this. |
|
|
Yadav, VK, Yadav, et al |
Evergreen |
Epidemiology| Épidémiologie |
In this work, a comparative study of the spreading trends of Covid-19 in India and USA is presented. For investigating
the trends of Covid-19 pandemic spread in India and USA, a statistical model based on Least Square Method (LSM) is proposed. The parameters affecting the spread pattern and steeper rise in Covid-19 graph is discussed in detail. From the trend line predictions,
using LSM, it is observed that the spread pattern follows a second degree polynomial for India as well as USA. In addition, the numerical results revealed in the present work agree well with the actual spray pattern of the Covid-19 pandemic for both countries.
The results also showed that the early stage spread rate of Covid-19 pandemic in India is very less as compared to USA due to the adoption of precautionary measures at the beginning of the pandemic spread. |
|
|
Yasui, Y, Yasui, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to examine the relationship between the patient's serum zinc level and severe cases of COVID-19. Serum zinc
<70 μg/dL was defined as the criterion for hypozincemia, and patients continuously with serum zinc <70 μg/dL were classified in the hypozincemia cohort. To evaluate whether hypozincemia could be a predictive factor for a critical illness of COVID-19, we performed
a multivariate analysis by employing logistic regression analysis. Prolonged hypozincemia was found to be a risk factor for a severe case of COVID-19. In evaluating the relationship between the serum zinc level and severity of patients with COVID-19 by multivariate
logistic regression analysis, critical illness can be predicted through the sensitivity and false specificity of a ROC curve with an error rate of 10.3% and AUC of 94.2% by only two factors: serum zinc value (P = 0.020) and LDH value (P = 0.026). |
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Analysis of Continuous Mutation and Evolution on Circulating SARS-CoV-2 |
Yu, JM, Zhang, et al |
Evolutionary Bioinformatics |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
A total of 342 complete genomic sequences of SARS-CoV-2 were analyzed in this study. Compared to the reference genome
reported in December 2019, 465 mutations were found, among which, 347 occurred in only 1 sequence, while 26 occurred in more than 5 sequences. For these 26 further identified as SNPs, 14 were closely linked and were grouped into 5 profiles. Phylogenetic analysis
revealed the sequences formed 2 major groups. Most of the sequences in late period (March and April) constituted the Cluster II, while the sequences before March in this study and the reported S/L and A/B/C types in previous studies were all in Cluster I.
The distributions of some mutations were specific geographically or temporally, the potential effect of which on the transmission and pathogenicity of SARS-CoV-2 deserves further evaluation and monitoring. Two mutations were found in the receptor-binding domain
(RBD) but outside the receptor-binding motif (RBM), indicating that mutations may only have marginal biological effects but merit further attention. The observed novel sequence divergence is of great significance to the study of the transmission, pathogenicity,
and development of an effective vaccine for SARS-CoV-2. |
|
Zhang, H, Dimitrov, et al |
JMIR Form Res |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to describe the design and development of the COVID Pass COVID-19 symptom screening application
and report aggregate usage data from the first three months of its use across the organization. We developed the minimum viable product (MVP) of a mobile-responsive, web-based, self-service application using research electronic data capture (REDCap). For
employees without access to a computer or mobile device to use the self-service application, we established a manual process where in-person, socially distanced screeners asked employees entering the site if they have symptoms and then manually recorded the
responses in an Office 365 Form. A custom .NET Framework application solution was developed as COVID Pass was scaled. Aggregate descriptive statistics, including overall employee attestations by day and site, employee attestations by application method (COVID
Pass automatic screening vs manual screening), employee attestations by time of day, and percentage of employees reporting COVID-19 symptoms, were obtained. After three months, 2,169,406 attestations were recorded with COVID Pass. Over this period, 1865/160,159
employees (1.2%) reported positive symptoms. 1,976,379 of the 2,169,406 attestations (91.1%) were generated from the self-service screening application. The remainder were generated either from manual attestation processes (174,865/2,169,406, 8.1%) or COVID
Pass kiosks (25,133/2,169,406, 1.2%). Hospital staff continued to work 24 hours per day, with staff attestations peaking around shift changes between 7 and 8 AM, 2 and 3 PM, 4 and 6 PM, and 11 PM and midnight. We identified 1865 symptomatic employees who otherwise
may have come to work, potentially putting others at risk. |
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Covid-19 with pleural effusion as the initial symptom: A case study analysis |
Zhang, J, Chai, et al |
Annals of Palliative Medicine |
Clinical data| Données cliniques |
This report presents a case study analysis of a patient admitted in the Fourth Taiyuan People’s Hospital, who had suffered
traumatic injuries from a car accident and survived COVID-19, with pleural effusion as the initial symptom. We report a case of 2019-NCOV with pleural effusion as the first symptom. Describe in detail the differential diagnosis, diagnosis, clinical management,
and cure of this case. In order to combat the novel CoronaviruscoVID-19 in the process to provide lessons and help. |
|
Zhang, Jonathan, Boden, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
Methods: This longitudinal observational study analyzes veterans receiving mental health treatment at a Veterans Health
Administration (VHA) facility from January 1, 2017 to June 16, 2020. Observed and expected patient care for on-going and new treatment of depression, posttraumatic stress, substance use disorder, severe mental illness diagnoses, overdose, and suicide attempts,
and psychotropic prescriptions for antidepressant, antipsychotic, benzodiazepine, opioid, and mood stabilizing medications are depicted. Percent change between actual and expected counts in the early months of the COVID pandemic are computed. Results: Decreases
in counts of patients receiving care for mental health treatment during early pandemic response ranged from 7% to 20% for on-going treatment, and 28 to 37% for new treatment. TMH rapidly expanded across VHA, becoming the primary means by which encounters were
delivered. The number of patients receiving on-going care for suicide attempts were stable and for overdoses, decreased 17%, while patients initiating care declined by 30% and 38%, respectively. Weekly prescriptions and medication on-hand for psychotropics
ranged from a 2% decline to 4% increase. Prescribing to new patients declined 21 to 50%. |
|
|
Effects of irritability of the youth on subjective well-being: Mediating effect
of coping styles |
Zhang, L, Yao, et al |
Iranian Journal of Public Health |
Public Health response| Interventions de santé publique |
Overall, 1,033 youth respondents (aged 18–30 yr) from seven provinces in China were investigated in 2020 using the
irritability, depression, and anxiety scale, coping style scale, and well-being index scale. Among the dimensions of irritability of the youth, anxiety received the highest score, followed by introversion irritability, extroversion irritability, and depression.
Irritability had significant regional differences. The total score of irritability among rural youth was significantly higher than that of urban youth (P<0.05). The irritability level of youths with parents’ emotional status was harmonious and good relations
with family members and peers was far lower than those of youths who have poor relations between parents, family members, and peers (P<0.05). The irritability level of youths with a lower monthly household income was higher (P<0.05). Irritability of the youth
had significantly negative correlations with positive response and SWB, and it had a significantly positive correlative with negative response. Coping style can mediate the relationship between irritability and SWB of the youth to some extent. |
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Cell morphological analysis of SARS-CoV-2 infection by transmission electron microscopy |
Zhao, J, Zhou, et al |
Journal of Thoracic Disease |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
We used transmission electron microscopy (TEM) to compare the morphology of the HCoV-229E and SARS-CoV-2 coronaviruses
in ultrathin sections of sensitive infected cells and to further investigate the morphology of cells in bronchoalveolar lavage fluid (BALF) from two ICU patients with confirmed SARS-CoV-2 infection, so as to providing morphological bases for study of SARS-CoV-2.
Our study shows that the morphology of SARS-CoV-2 did not differ significantly from that of HCoV-229E, as determined by electron microscopy. TEM also showed that SARS-CoV-2 entered cells through membrane fusion and matured in vesicles. This phenomenon suggests
that the life cycle of SARS-CoV-2 might be similar to that of SARS-CoV. We also observed ultrastructural deterioration of the ciliated columnar epithelium in BALF from COVID-19 patients via TEM, which is consistent with pathological changes of COVID-19. So
the establishment of animal models of SARS-CoV-2 infection is necessary for further study of the infection, transmission and pathogenesis of this disease. |
|
Zheng, KL, Xu, et al |
Aging (Albany NY) |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We enrolled 181 patients admitted to Huoshenshan Hospital (Wuhan, China) with confirmed COVID-19 between January 2020
and February 2020. Ninety-two patients were treated with tocilizumab, and 89 patients were treated conventionally. We analyzed the clinical manifestations, changes in CT scan images, and laboratory tests before and after tocilizumab treatment, and compared
these results with the conventionally treated group. A significant reduction in the level of C-reactive protein was observed 1 week after tocilizumab administration. In some cases this meant the end of the IL-6-related cytokine storm. In addition, tocilizumab
relieved fever, cough, and shortness of breath with no reported adverse drug reactions. These findings suggest tocilizumab improves clinical outcomes and is effective for treatment of patients with critical or severe COVID-19. |
|
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Rapid and sensitive detection of SARS-CoV-2 with functionalized magnetic nanoparticles |
Zhong, Jing, Roesch, et al |
arXiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This paper proposes an approach for rapid and sensitive detection of SARS-CoV-2 with functionalized MNPs via the measurement
of their magnetic response in an ac magnetic field. Experimental results demonstrate that the proposed approach allows the rapid detection of mimic SARS-CoV-2 with a limit of detection of 0.084 nM (5.9 fmole). The proposed approach has great potential for
designing a low-cost and point-of-care device for rapid and sensitive diagnostics of SARS-CoV-2. |
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Managing acute appendicitis during the COVID-19 pandemic in Jiaxing, China |
Zhou, Y, Cen, et al |
World Journal of Clinical Cases |
Healthcare Response | Réponse des soins de santé |
To assess the efficacy of the management of acute appendicitis during the COVID-19 pandemic. We retrospectively analyzed
90 patients who presented with acute appendicitis during the outbreak of COVID-19 in Jiaxing, China. After screening, six patients were identified as unqualified due to fever and were then referred to the COVID-19 expert group. The results of the nucleic acid
test were negative. Of the 76 patients enrolled in the simple group, nine patients received medication therapy, and all others underwent surgery. From this same group, 66 patients were diagnosed with suppurative appendicitis, and one patient was diagnosed
with perforated appendicitis after surgery. There were 14 patients in the complex group, for which the postoperative diagnosis indicated perforated appendicitis. The proportion of men with perforated appendicitis was higher than that in 2019 (P < 0.05). The
chief complaint duration for perforated appendicitis patients in 2020 was longer than that in 2019 (P < 0.05). The routine blood test showed that white blood cell counts and neutrophil ratios were higher in perforated appendicitis patients in 2020 than in
2019 (P < 0.05). The ratio of open appendectomies to the amount of mean blood loss during surgery was greater in 2020 than in 2019 (P < 0.05). Online consultation after discharge was selected in 59 cases (65.6%). No perioperative infection with COVID-19 or
long-term postoperative complications were found. |
|
Zine, Houssine, Lotfi, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We propose a delayed mathematical model to predict the epidemiological trend of COVID-19 in Morocco. Parameter estimation
and sensitivity analysis of the proposed model are rigorously studied. Moreover, numerical simulations are presented in order to test the effectiveness of the preventive measures and strategies that were imposed by the Moroccan authorities and also help policy
makers and public health administration to develop such strategies. |
|
|
Zini, A, Romoli, et al |
Neurol Sci |
Healthcare Response | Réponse des soins de santé |
We analyze stroke code admissions, hospitalizations, and stroke belt performance for ischemic stroke patients in the
metropolitan Bologna region, comparing temporal trends between 2019 and 2020 to define the impact of COVID-19 on the stroke network. This retrospective observational study included all people admitted at the Bologna Metropolitan Stroke Center in timeframes
1 March 2019-30 April 2019 (cohort-2019) and 1 March 2020-30 April 2020 (cohort-2020). Diagnosis, treatment strategy, and timing were compared between the two cohorts to define temporal trends. Overall, 283 patients were admitted to the Stroke Center, with
no differences in demographic factors between cohort-2019 and cohort-2020. In cohort-2020, transient ischemic attack (TIA) was significantly less prevalent than 2019 (6.9% vs 14.4%, p = .04). Among 216 ischemic stroke patients, moderate-to-severe stroke was
more represented in cohort-2020 (17.8% vs 6.2%, p = .027). Similar proportions of patients underwent reperfusion (45.9% in 2019 vs 53.4% in 2020), although a slight increase in combined treatment was detected (14.4% vs 25.4%, p = .05). Door-to-scan timing
was significantly prolonged in 2020 compared with 2019 (28.4 ± 12.6 vs 36.7 ± 14.6, p = .03), although overall timing from stroke to treatment was preserved. |
|
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Psychological states of Bangladeshi people four months after the COVID-19 pandemic: An online
survey |
Zubayer, AA, Rahman, et al |
Heliyon |
Public Health response| Interventions de santé publique |
The present study aimed to assess the prevalence of depression, anxiety, and stress among Bangladeshi people four months
after the COVID-19 outbreak. An online cross-sectional survey was conducted among Bangladeshi citizens aged ≥18 years from June 1 to June 10, 2020. The participants completed an online questionnaire examining socio-demographic variables and COVID-19 related
factors, along with the Depression Anxiety and Stress Scale 21. A total of 1146 respondents have been included in the study. Data were analyzed using the Statistical Package for Social Sciences, IBM Statistics version 22.0. The prevalence of moderate to the
extremely severe levels of depression, anxiety, and stress was 47.2%, 46.0%, and 32.5%, respectively, with no significant gender differences. The prevalence of anxiety and stress was significantly higher in participants aged >30 than in participants aged 18–30
years. Daily follow up COVID-19 related news, having COVID-19 symptoms so far, having contact (direct or indirect) with COVID-19 infected person, and fear of infection were significantly associated with depression, anxiety, and stress. |
|
Zulkifley, MA, Abdani, et al |
Symmetry |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
A deep learning approach has been proposed to automate the screening process by introducing LightCovidNet, a lightweight
deep learning model that is suitable for the mobile platform. The model has been trained with additional synthetic data that were generated from the conditional deep convolutional generative adversarial network. LightCovidNet consists of three components,
which are entry, middle, and exit flows. The middle flow comprises five units of feed-forward convolutional neural networks that are built using separable convolution operators. The exit flow is designed to improve the multi-scale capability of the network
through a simplified spatial pyramid pooling module. It is a symmetrical architecture with three parallel pooling branches that enable the network to learn multi-scale features, which is suitable for cases wherein the X-ray images were captured from all over
the world independently.The proposed method managed to get the best mean accuracy of 0.9697 with a low memory requirement of just 841,771 parameters. Moreover, the symmetrical spatial pyramid pooling module is the most crucial component; the absence of this
module will reduce the screening accuracy to just 0.9237. Hence, the developed model is suitable to be implemented for mass COVID-19 screening. |
|
|
Abdul Rahim, R, Muhammad, et al |
International Medical Journal Malaysia |
Review Literature| Revue de littérature |
|
|
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Restoration of reproductive health in women who recover from COVID-19. Several aspects |
Adamyan, LV, Baibarina, et al |
Russian Journal of Human Reproduction |
Review Literature| Revue de littérature |
|
|
Al-Horani, R, Kar, et al |
Viruses |
Review Literature| Revue de littérature |
|
|
|
Ali, MY, Naeem, et al |
Journal of Hospital Librarianship |
Review Literature| Revue de littérature |
|
|
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Effectiveness of Ozone Gas on Airborne Virus Inactivation in Enclosed Spaces: A Review Study |
Alimohammadi, M, Naderi, et al |
Ozone: Science and Engineering |
Review Literature| Revue de littérature |
|
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Urticaria and coronavirus infection: a lesson from SARS-CoV-2 pandemic |
Allegra, A, Asero, et al |
Eur Ann Allergy Clin Immunol |
Review Literature| Revue de littérature |
|
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32979914; Case Fatality Rate of COVID-19: Meta-Analysis Approach |
Almasi-Hashiani, A, Doosti-Irani, et al |
Archives of Iranian medicine |
Review Literature| Revue de littérature |
MA |
|
Effectiveness of COVID-19 diagnosis and management tools: A review |
Alsharif, W, Qurashi, et al |
Radiography |
Review Literature| Revue de littérature |
|
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Six decades of lateral flow immunoassay: From determining metabolic markers to diagnosing covid-19 |
Andryukov, BG |
AIMS Microbiology |
Review Literature| Revue de littérature |
|
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Atangana, E, Atangana, et al |
Results Phys |
Review Literature| Revue de littérature |
|
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Seasonality of Respiratory Viral Infections: Will COVID-19 Follow Suit? |
Audi, A, AlIbrahim, et al |
Frontiers in Public Health |
Review Literature| Revue de littérature |
|
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COVID-19 transmission risk and protective protocols in dentistry: a systematic review |
Banakar, M, Bagheri Lankarani, et al |
BMC Oral Health |
Review Literature| Revue de littérature |
SR: searched Pubmed, Web of Science, and SCOPUS electronic databases using MESH terms from01.01.2020 until 10.05.2020.
While the currently available evidence has not demonstrated a clear and direct relationship between dental treatment or surgery and the possibility of the transmission of COVID-19, there is clearly the potential for transmission. |
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Exploring the smart future of participation: Community, inclusivity, and people with disabilities |
Bricout, J, Baker, et al |
International Journal of E-Planning Research |
Review Literature| Revue de littérature |
|
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Prevalence of depression during the COVID-19 outbreak: A meta-analysis of community-based studies |
Bueno-Notivol, J, Gracia-García, et al |
International Journal of Clinical and Health Psychology |
Review Literature| Revue de littérature |
MA: searched for cross-sectional, community-based studies listed on PubMed or Web of Science from January 1, 2020 to
May 8, 2020. Compared with a global estimated prevalence of depression of 3.44% in 2017, our pooled prevalence of 25% appears to be 7 times higher, thus suggesting an important impact of the COVID-19 outbreak on people's mental health. |
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SARS-CoV-2 (COVID-19) in Patients with some Degree of Immunosuppression |
Cajamarca-Baron, J, Guavita-Navarro, et al |
Reumatologia Clinica |
Review Literature| Revue de littérature |
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An immersive journey to the molecular structure of SARS-CoV-2: Virtual reality in COVID-19 |
Calvelo, M, Piñeiro, et al |
Computational and Structural Biotechnology Journal |
Review Literature| Revue de littérature |
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Atypical chest CT findings of COVID-19 pneumonia: a pictorial review |
Ceylan, N, Çinkooğlu, et al |
Diagn Interv Radiol |
Review Literature| Revue de littérature |
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A review of vaccine effects on women in light of the COVID-19 pandemic |
Chang, WH |
Taiwanese Journal of Obstetrics and Gynecology |
Review Literature| Revue de littérature |
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Chastin, Sebastien, Abaraogu, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
SR-MA: MEDLINE, Embase, Cochrane CENTRAL, Web of Science, CINAHL, PsycINFO, and SportDiscus were searched up to April
2020. There appear to be no moderating effects of physical activity volume, intensity or type. Interpretation: The practice of any type of regular, moderate to vigorous physical activity appears to be associated with enhanced immunosurveillance and mucosal
immune responses. This is likely to explain the significant risk reduction of community acquired infectious diseases and infectious disease mortality, as well as an increase in the potency of vaccination. |
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Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin System |
Costa, LB, Perez, et al |
Frontiers in Cell and Developmental Biology |
Review Literature| Revue de littérature |
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de Paiva, REF, Marçal Neto, et al |
Dalton Trans |
Review Literature| Revue de littérature |
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Dey, JK, Mukherjee, et al |
International Journal of High Dilution Research |
Review Literature| Revue de littérature |
SR: Data were collected from the Library of Central Council for Research in Homoeopathy, India; Cochrane Library; Google
Scholar, PubMed and AYUSH portal, India. |
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Dresler, T, Guth, et al |
Schmerz |
Review Literature| Revue de littérature |
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Elbishlawi, S, Abdelpakey, et al |
Journal of Imaging |
Review Literature| Revue de littérature |
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Therapeutic Options Against the New Coronavirus: Updated Clinical and Laboratory Evidences |
Fernandes, ACL, Vale, et al |
Frontiers in Medicine |
Review Literature| Revue de littérature |
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Forouzandeh, P, O'Dowd, et al |
Safety Science |
Review Literature| Revue de littérature |
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Gaisenok, OV |
Rational Pharmacotherapy in Cardiology |
Review Literature| Revue de littérature |
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Diabetes in the time of COVID-19 pandemic: A knife with two sharp ends |
Ghosh, S, Dey, et al |
Indian Journal of Biochemistry and Biophysics |
Review Literature| Revue de littérature |
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Using mobile applications and websites for the diagnosis of COVID-19 in Spain |
Guisado-Clavero, M, Ares-Blanco, et al |
Enfermedades infecciosas y microbiologia clinica |
Review Literature| Revue de littérature |
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FIREBall-2: The Faint Intergalactic Medium Redshifted Emission Balloon Telescope |
Hamden, E, Martin, et al |
Astrophysical Journal |
Review Literature| Revue de littérature |
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Han, J, Zhang, et al |
Environmental Chemistry Letters |
Review Literature| Revue de littérature |
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Han, RH, Schmidt, et al |
Curr Psychiatry Rep |
Review Literature| Revue de littérature |
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Irfan Ul Haq, M, Khuroo, et al |
Research on Biomedical Engineering |
Review Literature| Revue de littérature |
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A Review of Venous Thromboembolism Phenomena in COVID-19 Patients |
Kermani-Alghoraishi, M, Ghahramani, et al |
Current problems in cardiology |
Review Literature| Revue de littérature |
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Kirksey, MA, Yang, et al |
HSS Journal |
Review Literature| Revue de littérature |
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Koh, WC, Naing, et al |
PLoS One |
Review Literature| Revue de littérature |
SR-MA: searched PubMed, medRxiv, and bioRxiv databases between January 1 and July 25, 2020. While aggressive contact
tracing strategies may be appropriate early in an outbreak, as it progresses, measures should transition to account for setting-specific transmission risk. Quarantine may need to cover entire communities while tracing shifts to identifying transmission hotspots
and vulnerable populations. Where possible, confirmed cases should be isolated away from the household. |
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Laganà, AS, Unfer, et al |
Medical hypotheses |
Review Literature| Revue de littérature |
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Lauritano, D, Moreo, et al |
Applied Sciences (Switzerland) |
Review Literature| Revue de littérature |
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Effects of covid-19 pandemic on health and wellbeing of older people: A comprehensive review |
Lekamwasam, R, Lekamwasam, et al |
Annals of Geriatric Medicine and Research |
Review Literature| Revue de littérature |
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Lim, T, Lee, et al |
Global Media and China |
Review Literature| Revue de littérature |
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Liver injury could be associated with severe disease in COVID-19 patients: a meta-analysis |
Liu, C, Yang, et al |
Eur J Gastroenterol Hepatol |
Review Literature| Revue de littérature |
MA |
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Influence of Convalescent Plasma Therapy on the Mortality in COVID-19 Patients: A Meta-Analysis |
Liu, Xingxiang, Wu, et al |
Research Square prepub |
Review Literature| Revue de littérature |
MA: searched the English literature library Pubmed, Embase, web of science, Chinese literature CNKI and CQVIP up to
July 31, 2020. After pooling included studies together, our present meta-analysis found that use of convalescent plasma from those recovered COVID-19 patients could significantly reduce mortality in patients with severe/critical SARS-CoV-2 infection. |
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Transmission risk of infectious droplets in physical spreading process at different times:
A review |
Mao, N, An, et al |
Building and Environment |
Review Literature| Revue de littérature |
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Angiotensin-converting enzyme 2: A protective factor in regulating disease virulence of SARS-COV-2 |
Mariappan, V, S, et al |
IUBMB life |
Review Literature| Revue de littérature |
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Resident learning during a pandemic: Recommendations for training programs |
Mok, G, Schouela, et al |
Canadian Journal of Emergency Medicine |
Review Literature| Revue de littérature |
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Technology use by urban local bodies in India to combat the COVID-19 pandemic |
Mukherjee, F |
International Journal of E-Planning Research |
Review Literature| Revue de littérature |
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The benefits of Vitamin D in the COVID-19 pandemic: biochemical and immunological mechanisms |
Musavi, H, Abazari, et al |
Arch Physiol Biochem |
Review Literature| Revue de littérature |
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Positioning libraries in meeting public health challenges in india: Key strategies |
Narang, S |
Journal of Scientometric Research |
Review Literature| Revue de littérature |
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Naseem, M, Akhund, et al |
Journal of Primary Care and Community Health |
Review Literature| Revue de littérature |
ScR: search conducted through the PubMed. AI-based tools can be a game-changer for diagnosis, treatment, and management
of COVID-19 patients with the potential to reshape the future of healthcare in LMIC.
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Role of heterocyclic compounds in SARS and SARS CoV-2 pandemic |
Negi, M, Chawla, et al |
Bioorganic chemistry |
Review Literature| Revue de littérature |
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A review on scope of immuno-modulatory drugs in Ayurveda for prevention and treatment of Covid-19 |
Niraj, S, Varsha, et al |
Plant Science Today |
Review Literature| Revue de littérature |
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Tackling SARS-CoV-2 Infections using Remdesivir and Favipiravir as Therapeutic Options |
Obireddy, SR, Wing-Fu, et al |
Chembiochem |
Review Literature| Revue de littérature |
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O'Hearn, K, Gertsman, et al |
Journal of Hospital Infection |
Review Literature| Revue de littérature |
SR: Embase, Medline, Global Health, Google Scholar, WHO feed, and MedRxiv were searched from January 1st, 1972 to
March 31st, 2020. A single cycle of vaporized hydrogen peroxide (H2O2) successfully removes viral pathogens without affecting airflow resistance or fit, and maintains an initial filter penetration of <5%, with little change in FFR appearance. |
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Okita, Yasutaka, Morita, et al |
Research Square prepub |
Review Literature| Revue de littérature |
SR-MA: PubMed and Web of Science were searched to identify articles published until April 28, 2020. Severity, steroid
usage, and locality may affect the viral shedding period. |
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Otręba, M, Kośmider, et al |
European journal of pharmacology |
Review Literature| Revue de littérature |
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Effect of different human tissue processing techniques on SARS-CoV-2 inactivation-review |
Paggiaro, AO, Carvalho, et al |
Cell Tissue Bank |
Review Literature| Revue de littérature |
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Metabolic associated fatty liver disease increases the severity of COVID-19: A meta-analysis |
Pan, L, Huang, et al |
Digestive and Liver Disease |
Review Literature| Revue de littérature |
MA: search using PubMed, EMBASE, Medline (OVID), and MedRxiv from inception to July 6, 2020. In this meta-analysis,
we found that a high percentage of patients with COVID-19 had MAFLD. |
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Parker, J, Boles, et al |
Toxicol Ind Health |
Review Literature| Revue de littérature |
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Philips, CA, Mohan, et al |
World Journal of Clinical Cases |
Review Literature| Revue de littérature |
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Pierri, MD, Alfonsi, et al |
J Card Surg |
Review Literature| Revue de littérature |
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Poland, GA, Ovsyannikova, et al |
Mayo Clinic proceedings |
Review Literature| Revue de littérature |
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Intra-crisis learning and prospective policy transfer in the COVID-19 pandemic |
Powell, M, King–Hill, et al |
International Journal of Sociology and Social Policy |
Review Literature| Revue de littérature |
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Raeisi, Tahereh, Mozaffari, et al |
Research Square prepub |
Review Literature| Revue de littérature |
SR-MA: search of Scopus, Medline, and Web of Sciences was conducted on June 2020. Obesity is associated with COVID-19
and its poor clinical outcomes. Thus, it is highly recommended to consider obesity status in prognostic scores and improvement of guidelines for the clinical care of patients with COVID-19. |
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Razeghian-Jahromi, I, Elyaspour, et al |
International Cardiovascular Research Journal |
Review Literature| Revue de littérature |
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Umbilical cord: an allogenic tissue for potential treatment of COVID-19 |
Rodriguez, HC, Gupta, et al |
Hum Cell |
Review Literature| Revue de littérature |
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Roper, S, Turner, et al |
International Small Business Journal: Researching Entrepreneurship |
Review Literature| Revue de littérature |
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Antibodies at work in the time of severe acute respiratory syndrome coronavirus 2 |
Sajna, KV, Kamat, et al |
Cytotherapy |
Review Literature| Revue de littérature |
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Salzberger, B, Buder, et al |
Infection |
Review Literature| Revue de littérature |
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Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives |
Sarkar, C, Mondal, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
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Opportunities and challenges for radar sensing for pandemics: COVID-19 |
Shariff, KKM, Rahim, et al |
International Journal of Emerging Trends in Engineering Research |
Review Literature| Revue de littérature |
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Sherren, PB, Ostermann, et al |
British journal of anaesthesia |
Review Literature| Revue de littérature |
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New therapeutic strategies in
treating the new Coronavirus 2019: Review article |
Sheykhhasan, M, Manoochehri, et al |
Tehran University Medical Journal |
Review Literature| Revue de littérature |
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The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19 |
Sifat, AE, Nozohouri, et al |
J Pharmacol Exp Ther |
Review Literature| Revue de littérature |
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Takano, AM |
Proceedings of Singapore Healthcare |
Review Literature| Revue de littérature |
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Terruzzi, I, Senesi, et al |
Nutrition |
Review Literature| Revue de littérature |
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Tsatsakis, A, Calina, et al |
Food and Chemical Toxicology |
Review Literature| Revue de littérature |
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32971105; Cardiac inflammation in COVID-19: Lessons from heart failure |
Unudurthi, SD, Luthra, et al |
Life Sciences |
Review Literature| Revue de littérature |
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Palliative sedation: Has anything changed during the pandemic? |
Vilches-Aguirre, Y, Fariñas-Balaguer, et al |
Medicina Paliativa |
Review Literature| Revue de littérature |
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Pharmacological agents to therapeutic treatment of cardiac injury caused by Covid-19 |
Vitiello, A, Ferrara, et al |
Life Sciences |
Review Literature| Revue de littérature |
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Wundavalli, L, Singh, et al |
BMJ open quality |
Review Literature| Revue de littérature |
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Yang Chan, EY, Shahzada, et al |
Br Med Bull |
Review Literature| Revue de littérature |
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The public health response to the COVID-19 outbreak in mainland China: A narrative review |
Zanin, M, Xiao, et al |
Journal of Thoracic Disease |
Review Literature| Revue de littérature |
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Selenium and selenoproteins in viral infection with potential relevance to COVID-19 |
Zhang, J, Saad, et al |
Redox Biology |
Review Literature| Revue de littérature |
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32926868; Masks or N95 Respirators During COVID-19 Pandemic–Which One Should I Wear? |
Zhang, M, Emery, et al |
Journal of Oral and Maxillofacial Surgery |
Review Literature| Revue de littérature |
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Zhao, JN, Fan, et al |
World Journal of Clinical Cases |
Review Literature| Revue de littérature |
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The role of virtual reality in the changing landscape of surgical training |
Abbas, JR, Kenth, et al |
J Laryngol Otol |
Commentary/Editorial| Commentaire/Éditorial |
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Abdelmaksoud, A, Goldust, et al |
International journal of dermatology |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: Providing rehabilitation care in the time of pandemic |
Abu Hassan, SA |
International Medical Journal Malaysia |
Commentary/Editorial| Commentaire/Éditorial |
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What services should be guaranteed in universal health-care systems? |
Adja, KYC, Golinelli, et al |
Journal of Primary Health Care |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations for sedation outside the operating room during the COVID-19 pandemic |
Aguilar, LS |
Colombian Journal of Anesthesiology |
Commentary/Editorial| Commentaire/Éditorial |
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Al Bujuq, N |
Synthesis (Germany) |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 pandemic: Learning lessons and a vision for a better health system |
Al Fannah, J, Al Harthy, et al |
Oman Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Al-Mandhari, A |
Eastern Mediterranean Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Al-Mansour, J, Al-Ajmi, et al |
Journal of Asian Finance, Economics and Business |
Commentary/Editorial| Commentaire/Éditorial |
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32914749; Revisiting clinical autopsies: Lessons to be taken from the COVID-19 pandemic |
Almeida, R, Oliveira, et al |
Acta Medica Portuguesa |
Commentary/Editorial| Commentaire/Éditorial |
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The impact of e-learning modalities on medical students in KSA during the COVID-19 pandemic |
Almulhim, AY, Almulhim, et al |
Journal of Taibah University Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Visual Risk Literacy in “Flatten the Curve” COVID-19 Visualizations |
Amidon, TR, Nielsen, et al |
Journal of Business and Technical Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Anderson, S |
World Leisure Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Anttiroiko, AV |
International Journal of E-Planning Research |
Commentary/Editorial| Commentaire/Éditorial |
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Ash, C |
Science |
Commentary/Editorial| Commentaire/Éditorial |
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Challenges of home health care during COVID-19 outbreak in Iran |
Atashi, A, Nejatian, et al |
International Journal of Community Based Nursing and Midwifery |
Commentary/Editorial| Commentaire/Éditorial |
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Otolaryngology Surgical Activity in Tertiary Care Center During the Covid-19 Lockdown |
Atru, B, Sutrave, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Avery, DR |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Baehr, M |
Journal of Scholarly Publishing |
Commentary/Editorial| Commentaire/Éditorial |
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Safety and health protection of health care workers during the COVID-19 pandemic |
Bagheri, S, Ghobadimoghadam, et al |
International Journal of Community Based Nursing and Midwifery |
Commentary/Editorial| Commentaire/Éditorial |
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Covert Pathways to the Cranial Cavity: Could These Be Potential Routes of SARS-CoV-2 to the
Brain? |
Baig, AM |
ACS Chem Neurosci |
Commentary/Editorial| Commentaire/Éditorial |
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Elderly-onset rheumatoid arthritis: An outlook from a practicing rheumatologist |
Baimukhamedov, Ch |
Nauchno-Prakticheskaya Revmatologiya |
Commentary/Editorial| Commentaire/Éditorial |
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Baliś, B, Byrski, et al |
International Review on Modelling and Simulations |
Commentary/Editorial| Commentaire/Éditorial |
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Non-dyspnogenic Acute Hypoxemic Respiratory Failure in COVID-19 Pneumonia |
Barreto-Filho, J, Seabra-Garcez, et al |
J Appl Physiol (1985) |
Commentary/Editorial| Commentaire/Éditorial |
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The Impact of the COVID-19 on Organizational and Information Systems Agility |
Batra, D |
Information Systems Management |
Commentary/Editorial| Commentaire/Éditorial |
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Service restriction during the COVID-19 pandemic and its impact on HbA(1c) : a surprising outcome |
Batten, L, Chandrajay, et al |
Diabet Med |
Commentary/Editorial| Commentaire/Éditorial |
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Beattie, RM, Ashton, et al |
Frontline Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
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Living with the COVID-19 pandemic: act now with the tools we have |
Bedford, Juliet, Enria, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Berrizbeitia, OF |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
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Bertroche, JT |
JAMA Otolaryngol Head Neck Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Bhatia, V, Mandal, et al |
WHO South-East Asia journal of public health |
Commentary/Editorial| Commentaire/Éditorial |
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Bierbooms, Jjpa, van Haaren, et al |
JMIR Form Res |
Commentary/Editorial| Commentaire/Éditorial |
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Blakemore, S |
Emergency Nurse |
Commentary/Editorial| Commentaire/Éditorial |
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Blukacz, Alice, Cabieses, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Current understanding and future directions for an occupational infectious disease standard |
Boles, C, Parker, et al |
Toxicol Ind Health |
Commentary/Editorial| Commentaire/Éditorial |
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Dystopia and quarantined markets–an interview with James Fitchett |
Bradshaw, A, Fitchett, et al |
Consumption Markets and Culture |
Commentary/Editorial| Commentaire/Éditorial |
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Brambilla, E, Iavicoli, et al |
Dental Cadmos |
Commentary/Editorial| Commentaire/Éditorial |
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Bullimore, S |
Cleanroom Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Burki, Talha |
The Lancet Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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The “new occupational normality” for anesthetists: Beyond the SARS-CoV-2 COVID-19 pandemic |
Calabrese, G |
Colombian Journal of Anesthesiology |
Commentary/Editorial| Commentaire/Éditorial |
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Update on biological risk for anesthetists taking care of patients affected by SARS-CoV2, COVID19 |
Calabrese, G |
Colombian Journal of Anesthesiology |
Commentary/Editorial| Commentaire/Éditorial |
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Callender, Brian, Obuobi, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Digital Tomosynthesis and COVID-19: An Improvement in the Assessment of Pulmonary Opacities |
Calvo, I, SantaCruz-Calvo, et al |
Archivos de Bronconeumologia |
Commentary/Editorial| Commentaire/Éditorial |
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Nasopharyngeal SARS-CoV-2 viral RNA shedding in patients with diabetes mellitus |
Cano, E, Corsini Campioli, et al |
Endocrine |
Commentary/Editorial| Commentaire/Éditorial |
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Inflammation, malnutrition, and SARS-CoV-2 infection: a disastrous combination |
Carretero Gómez, J, Mafé Nogueroles, et al |
Revista clinica espanola |
Commentary/Editorial| Commentaire/Éditorial |
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Carrillo-Esper, R, Melgar-Bieberach, et al |
Cirugia y Cirujanos (English Edition) |
Commentary/Editorial| Commentaire/Éditorial |
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Castañeda-Millán, DA, Pardo-Acuña, et al |
Urologia Colombiana |
Commentary/Editorial| Commentaire/Éditorial |
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Understanding the COVID-19 pandemic from a gender perspective |
Chang, WH |
Taiwanese Journal of Obstetrics and Gynecology |
Commentary/Editorial| Commentaire/Éditorial |
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The influences of the COVID-19 pandemic on medical service behaviors |
Chang, WH |
Taiwanese Journal of Obstetrics and Gynecology |
Commentary/Editorial| Commentaire/Éditorial |
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Charitos, IA, Ballini, et al |
World Journal of Clinical Cases |
Commentary/Editorial| Commentaire/Éditorial |
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Is COVID-19 being used as a weapon against Indigenous Peoples in Brazil? |
Charlier, Philippe, Varison, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Pandemic: The Lived Experiences of Older Adults in Aged Care Homes |
Chee, SY |
Millennial Asia |
Commentary/Editorial| Commentaire/Éditorial |
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Chen, YY, Zhuang, et al |
Asia Pacific Journal of Social Work and Development |
Commentary/Editorial| Commentaire/Éditorial |
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Resilience and Covid-19: action plans and strategies in a military community |
Chiu, PL, Yu, et al |
Asia Pacific Journal of Social Work and Development |
Commentary/Editorial| Commentaire/Éditorial |
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The decline of COVID-19-related deaths and the risk of underestimating the pandemic |
Cioffi, A |
Ethics, Medicine and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Cioffi, CC, Leve, et al |
Journal of substance abuse treatment |
Commentary/Editorial| Commentaire/Éditorial |
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Coleman, CG, Spicer, et al |
Med Educ |
Commentary/Editorial| Commentaire/Éditorial |
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Corradetti, G, Corvi, et al |
Retina Today |
Commentary/Editorial| Commentaire/Éditorial |
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Cousins, Sophie |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Early childhood education, government policies and mobilizations in times of pandemic |
Coutinho, AS, Côco, et al |
Praxis Educativa |
Commentary/Editorial| Commentaire/Éditorial |
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Cramer, S, Garrison, et al |
Journal of Business and Finance Librarianship |
Commentary/Editorial| Commentaire/Éditorial |
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Cranshaw, J |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Developing approaches to control SARS-CoV-2 in a public hospital |
Crespi, E, Velocci, et al |
Occupational Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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American Association for Cancer Research (AACR) virtual annual meeting II: June 22-24, 2020 |
Croasdell, G, Fernández-Llamazares, et al |
Drugs of the Future |
Commentary/Editorial| Commentaire/Éditorial |
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Study of critically ill patients with COVID-19 in New York City – Authors' reply |
Cummings, MatthewJ, O'Donnell, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Curley, SA, Currell, et al |
Cancer Nanotechnology |
Commentary/Editorial| Commentaire/Éditorial |
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Currie, G, Hewis, et al |
Journal of Medical Imaging and Radiation Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Cutcher-Gershenfeld, J, Baker, et al |
Negotiation Journal |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 control in low-income settings and displaced populations: What can realistically be
done? |
Dahab, M, Van Zandvoort, et al |
Conflict and Health |
Commentary/Editorial| Commentaire/Éditorial |
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Infodemic management in Iran: A necessity to control and response to COVID-19 |
Dakhesh, S, Zareivenovel, et al |
Gazi Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Hospital characteristics and COVID-19: Hidden figures in COVID-19 risk models |
Danesh, V, Arroliga, et al |
Heart and Lung |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19
in pregnancy: Pregnant women might be at greater risk for severe COVID-19 |
Dangal, G |
Kathmandu University Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Das, UN |
Archives of Medical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Persistent Patterns of Behavior: Two Infectious Disease Outbreaks 350 Years Apart |
Dasgupta, Utteeyo, Jha, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Moneybags for Billionaires, Body Bags for Workers: Organizing in the Time of Pandemics |
Davis-Faulkner, S, Sneiderman, et al |
New Labor Forum |
Commentary/Editorial| Commentaire/Éditorial |
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De Massis, A, Rondi, et al |
Journal of Management Studies |
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De Rosa, DR, Reda, et al |
Comunicazione Politica |
Commentary/Editorial| Commentaire/Éditorial |
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Hemorrhagic Neurologic Manifestations in COVID-19: An Isolated or Multifactorial Cause? |
Dhillon, PS, Chattopadhyay, et al |
AJNR Am J Neuroradiol |
Commentary/Editorial| Commentaire/Éditorial |
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Diagnostic tests for COVID-19 detection: A hybrid methodology |
Díaz-Badillo, A, De Lourdes Muñoz, et al |
Cirugia y Cirujanos (English Edition) |
Commentary/Editorial| Commentaire/Éditorial |
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Dobson, GP |
Frontiers in Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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32961116; COVID-19 and Ophthalmologic Education: A Call to Innovate |
Dohlman, JC |
American Journal of Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
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Building resilient, smart communities in a post-COVID Era: Insights from ireland |
Doyle, A, Hynes, et al |
International Journal of E-Planning Research |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: FDA defies Trump to publish rigorous vaccine development guidelines |
Dyer, O |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Dykes, BJ |
Journal of Management Inquiry |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7499784; COVID-19 conspiracy beliefs, health behaviors, and policy support |
Earnshaw, VA, Eaton, et al |
Transl Behav Med |
Commentary/Editorial| Commentaire/Éditorial |
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Protection and utilization of aquatic wildlife from a multi-dimensional perspective |
Fang, D, Zou, et al |
Journal of Fishery Sciences of China |
Commentary/Editorial| Commentaire/Éditorial |
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Farhud, DD |
Iranian Journal of Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Dangers of scientific bias against herbal drugs for coronavirus disease 2019 |
Fields, JM |
Journal of Integrative Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 response: the perspectives of infectious diseases physicians and clinical microbiologists |
Foley, DA, Tippett, et al |
Med J Aust |
Commentary/Editorial| Commentaire/Éditorial |
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Pandemics and Partisanship: Following Old Paths into Uncharted Territory |
Fowler, L, Kettler, et al |
American Politics Research |
Commentary/Editorial| Commentaire/Éditorial |
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Lack of safeguards in response to restrictive public health measures |
Freudenthal, Robert, Horowitz, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Fuller, PD |
Am J Health Syst Pharm |
Commentary/Editorial| Commentaire/Éditorial |
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A Haematologist's Guide to Coronavirus Disease 2019: Encyclopaedia or Doorstop? |
Gale, RP |
Acta Haematol |
Commentary/Editorial| Commentaire/Éditorial |
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Telemedicine for endocrinological care of transgender subjects during COVID-19 pandemic |
Gava, G, Seracchioli, et al |
Evid Based Ment Health |
Commentary/Editorial| Commentaire/Éditorial |
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The Emerging Role of Artificial Intelligence in the Fight Against COVID-19 |
Ghose, A, Roy, et al |
European urology |
Commentary/Editorial| Commentaire/Éditorial |
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Effect of covid-19 pandemic on mental health of the health care workers |
Ghosh, S, Ghosh, et al |
Indian Journal of Biochemistry and Biophysics |
Commentary/Editorial| Commentaire/Éditorial |
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Gil, FM, Cebrián Carretero, et al |
Revista Espanola de Cirugia Oral y Maxilofacial |
Commentary/Editorial| Commentaire/Éditorial |
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Gipponi, E, Grizzaffi, et al |
Comunicazione Politica |
Commentary/Editorial| Commentaire/Éditorial |
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Giri, S, Singh, et al |
Anestezi Dergisi |
Commentary/Editorial| Commentaire/Éditorial |
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32957150; Zum Beitrag †Mütter-Screening in einem COVID-19-Niedrig-Pandemiegebiet |
Glocker, MO |
Deutsche medizinische Wochenschrift |
Commentary/Editorial| Commentaire/Éditorial |
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Integrating New Staff into Endovascular Stroke-Treatment Workflows in the COVID-19 Pandemic |
Goyal, M, Kromm, et al |
AJNR Am J Neuroradiol |
Commentary/Editorial| Commentaire/Éditorial |
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Green, AO, Chellappah, et al |
British Journal of Oral and Maxillofacial Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Overdue for an Overhaul: How Opioid Treatment Programs Can Learn From COVID-19 |
Greenblatt, AD, Magidson, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Griffin, S |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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The concept of active aging in Europe and Russia in the face of the covid-19 pandemic |
Grigoryeva, I, Bogdanova, et al |
Laboratorium: Russian Review of Social Research |
Commentary/Editorial| Commentaire/Éditorial |
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Undermining breastfeeding will not alleviate the COVID-19 pandemic – Authors' reply |
Groß, Rüdiger, Conzelmann, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Grover, S, Chakrabarti, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Gu, Q, Hao, et al |
Journal of Thoracic Disease |
Commentary/Editorial| Commentaire/Éditorial |
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The illegitimate tent: Private use of public space at a San Francisco restaurant |
Gunderson, A |
Food and Foodways |
Commentary/Editorial| Commentaire/Éditorial |
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Out of the hut with doctors and economists, seminar at the University of Iceland |
Gunnarsdóttir, GA |
Laeknabladid |
Commentary/Editorial| Commentaire/Éditorial |
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The Disproportionate Burden of the COVID-19 Pandemic Among Pregnant Black Women |
Gur, RE, White, et al |
Psychiatry research |
Commentary/Editorial| Commentaire/Éditorial |
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Gusenbauer, M, Haddaway, et al |
Res Synth Methods |
Commentary/Editorial| Commentaire/Éditorial |
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The Battle Between Politics and Science Is Costing Us a Timely Victory Over the COVID-19 Pandemic |
Hahn, MB |
J Am Osteopath Assoc |
Commentary/Editorial| Commentaire/Éditorial |
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Haines, J, Esposito, et al |
Clin Exp Allergy |
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Halevy, N |
Judgment and Decision Making |
Commentary/Editorial| Commentaire/Éditorial |
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Teaching and Technology at the University of the South Pacific |
Halter, N |
Journal of Pacific History |
Commentary/Editorial| Commentaire/Éditorial |
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Hamzah |
Journal of Social Studies Education Research |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2: how safe is it to fly and what can be done to enhance protection? |
Harries, AD, Martinez, et al |
Trans R Soc Trop Med Hyg |
Commentary/Editorial| Commentaire/Éditorial |
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Heggen, K, Sandset, et al |
Bulletin of the World Health Organization |
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Covid-19, unemployment, and health: time for deeper solutions? |
Hensher, M |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Hermans, ANL, van der Velden, et al |
Clin Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 and climate change in the times of the Anthropocene |
Heyd, T |
Anthropocene Review |
Commentary/Editorial| Commentaire/Éditorial |
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Hidayat, D, Anisti, et al |
Jurnal Komunikasi: Malaysian Journal of Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Horton, Richard |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Huang, S, Wang, et al |
Medicine (Baltimore) |
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Huff, C |
Bmj |
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The global pandemic, policy space and fiscal rules to achieve stronger stabilization policies |
Hutchison, MM |
Seoul Journal of Economics |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: Adapting to change, general surgery at a district general hospital in the United Kingdom |
Ike, S, Ikechi, et al |
Journal of Perioperative Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Poverty of leadership, coronavirus and sustainable development in Nigeria |
Ikegbu, EA, Iwuchukwu, et al |
European Journal of Sustainable Development |
Commentary/Editorial| Commentaire/Éditorial |
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Public psychological health in covid-19 outbreak: Actions and shortcomings |
Jaberi, A |
International Journal of Community Based Nursing and Midwifery |
Commentary/Editorial| Commentaire/Éditorial |
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Crisis and continuity: Rural health care students respond to the COVID-19 outbreak |
Jackman, D, Konkin, et al |
Nurse Education in Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Dying Without COVID-19: End-of-Life Care for an Uninfected Incarcerated Patient |
Jacobsen, AP, Epstein, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Jacobson, L, Regan, et al |
Sex Reprod Health Matters |
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Janyam, S, Phuengsamran, et al |
WHO South-East Asia journal of public health |
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Jassar, AS, Perkins, et al |
J Card Surg |
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Jiang, Z, Hu, et al |
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Jo, WK, de Oliveira-Filho, et al |
Transbound Emerg Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Jørstad, HT, Piek, et al |
Neth Heart J |
Commentary/Editorial| Commentaire/Éditorial |
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Jun, G |
Transformation |
Commentary/Editorial| Commentaire/Éditorial |
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US Food and Drug Administration Support for Oncology Drug Development During COVID-19 |
Kadakia, KT, Pazdur, et al |
JAMA Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Hypercoagulability following COVID-19 infection: at what stage is it safe to do a free flap? |
Kanatas, A, Hart, et al |
British Journal of Oral and Maxillofacial Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Considerations for cancer immunotherapy during the COVID-19 pandemic |
Kanjanapan, Y, Yip, et al |
Med J Aust |
Commentary/Editorial| Commentaire/Éditorial |
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Kapatayes, N, Joondeph, et al |
Retina Today |
Commentary/Editorial| Commentaire/Éditorial |
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The four epidemiological stages in the global evolution of inflammatory bowel disease |
Kaplan, GG, Windsor, et al |
Nat Rev Gastroenterol Hepatol |
Commentary/Editorial| Commentaire/Éditorial |
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Commentary: APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort |
Kasparian, K, Graykowski, et al |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Kathirvel, N |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Move than moving online: Implications of the COVID-19 pandemic on curriculum development |
Keegan, DA, Bannister, et al |
Med Educ |
Commentary/Editorial| Commentaire/Éditorial |
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Cellular Senescence: Friend or Foe to Respiratory Viral Infections? |
Kelley, WJ, Zemans, et al |
Eur Respir J |
Commentary/Editorial| Commentaire/Éditorial |
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Kelly, PN |
Science |
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Khave, LJ, Vahidi, et al |
Acad Med |
Commentary/Editorial| Commentaire/Éditorial |
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32975568; Racism, Not Race, Drives Inequity Across the COVID-19 Continuum |
Khazanchi, R, Evans, et al |
JAMA network open |
Commentary/Editorial| Commentaire/Éditorial |
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Khetrapal Singh, P, Jhalani, et al |
WHO South-East Asia journal of public health |
Commentary/Editorial| Commentaire/Éditorial |
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32971023; Reflections of an Ophthalmology Trainee in the Time of COVID-19 |
Kim, DH |
American Journal of Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
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Kitchens, JW |
Retina Today |
Commentary/Editorial| Commentaire/Éditorial |
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President's message: alcohol use during the COVID-19 pandemic |
Kmiec, J |
J Addict Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Kropacz-Sobkowiak, S, Michalski, et al |
Klinika oczna |
Commentary/Editorial| Commentaire/Éditorial |
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Kuderer, NicoleM, Wulff-Burchfield, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Kumar, A, Saxena, et al |
SpringerBriefs in Applied Sciences and Technology |
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Kumar, A, Saxena, et al |
SpringerBriefs in Applied Sciences and Technology |
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Rational drug design and docking of the RNA Dependent RNA Polymerase Domain of NCoV |
Kumar, A, Saxena, et al |
SpringerBriefs in Applied Sciences and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Kumar, A, Saxena, et al |
SpringerBriefs in Applied Sciences and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Machine learning approach for COVID-19 crisis using the clinical data |
Kumar, NRP, Shetty, et al |
Indian Journal of Biochemistry and Biophysics |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and healthcare workers: Emerging patterns in Pamplona, Asia and Boston |
Lan, FY, Fernandez-Montero, et al |
Occupational Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Lane, HG, Turner, et al |
Public Health Rep |
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Models of maternity care for pregnant women during the COVID-19 pandemic |
Larki, M, Sharifi, et al |
Eastern Mediterranean Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Lau-Ng, R, Caruso, et al |
Journal of the American Geriatrics Society |
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LeBrun, DG |
Clin Orthop Relat Res |
Commentary/Editorial| Commentaire/Éditorial |
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Lee, B, Raszka W, et al |
Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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Protection of Medical Staff during Tracheotomy: Lessons Learned from the COVID-19 Pandemic |
Lee, DH, Kim, et al |
ORL J Otorhinolaryngol Relat Spec |
Commentary/Editorial| Commentaire/Éditorial |
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Convergence innovation in the digital age and in the COVID-19 pandemic crisis |
Lee, SM, Trimi, et al |
Journal of Business Research |
Commentary/Editorial| Commentaire/Éditorial |
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Leung, TI, Biskup, et al |
Rural and remote health |
Commentary/Editorial| Commentaire/Éditorial |
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Lev, D, Biber, et al |
Journal of travel medicine |
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Levesque, C |
Northern Logger and Timber Processor |
Commentary/Editorial| Commentaire/Éditorial |
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Challenges for mesenchymal stem cell-based therapy for COVID-19 |
Li, C, Zhao, et al |
Drug Design, Development and Therapy |
Commentary/Editorial| Commentaire/Éditorial |
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Natural Host–Environmental Media–Human: A New Potential Pathway of COVID-19 Outbreak |
Li, M, Yang, et al |
Engineering |
Commentary/Editorial| Commentaire/Éditorial |
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Abnormal
returns on tourism shares in the Chinese stock exchanges amid the COVID-19 pandemic |
Liew, VKS |
International Journal of Economics and Management |
Commentary/Editorial| Commentaire/Éditorial |
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The impact of the global crisis on the growth of SMEs: A resource system perspective |
Lim, DSK, Morse, et al |
International Small Business Journal: Researching Entrepreneurship |
Commentary/Editorial| Commentaire/Éditorial |
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A química dos saneantes em tempos de covid-19: Você sabe como isso funciona? |
Limaa, MLSO, Almeida, et al |
Quimica Nova |
Commentary/Editorial| Commentaire/Éditorial |
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Lin, EM, Goren, et al |
High Alt Med Biol |
Commentary/Editorial| Commentaire/Éditorial |
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Linz, D, van der Velden, et al |
IJC Heart and Vasculature |
Commentary/Editorial| Commentaire/Éditorial |
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Liu, M, Prestigiacomo, et al |
Psychiatry research |
Commentary/Editorial| Commentaire/Éditorial |
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Liu, Y, Xie, et al |
Medicine (Baltimore) |
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Locsin, RC, Dalanon, et al |
Philippine Journal of Nursing |
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Loh, Po-Shen |
arXiv |
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The role of tropospheric Ozone in flagging COVID-19 pandemic transmission |
Lolli, Simone, Vivone, et al |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
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Looi, JC, Allison, et al |
Australas Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Labor Issues in the Food Supply Chain Amid the COVID-19 Pandemic |
Luckstead, J, Nayga, et al |
Applied Economic Perspectives and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Precautions for weaning from invasive mechanical ventilation with critically ill COVID-19 |
Luo, M, Mei, et al |
Heart and Lung |
Commentary/Editorial| Commentaire/Éditorial |
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MacKenzie, CR, Green, et al |
HSS Journal |
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Stress and myths related to the COVID-19 pandemic’s effects on remote work |
Madero Gómez, S, Ortiz Mendoza, et al |
Management Research |
Commentary/Editorial| Commentaire/Éditorial |
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The Potential of Antiviral Peptides as COVID-19 Therapeutics |
Mahendran, ASK, Lim, et al |
Frontiers in Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Malek, AlexandreE, Raad, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Communicative governance to mitigate the COVID-19 pandemic: A case study of Delhi, India |
Mali, NV, Yerramsetti, et al |
International Journal of E-Planning Research |
Commentary/Editorial| Commentaire/Éditorial |
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Malliet, P, Reynès, et al |
Environmental and Resource Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Mamaysky, Isaac |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Telemedicine and Virtual Reality for Cognitive Rehabilitation: A Roadmap for the COVID-19 Pandemic |
Mantovani, E, Zucchella, et al |
Frontiers in Neurology |
Commentary/Editorial| Commentaire/Éditorial |
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McCall, MK, Skutsch, et al |
International Journal of E-Planning Research |
Commentary/Editorial| Commentaire/Éditorial |
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The Big Reveal: COVID-19 and Globalization's Great Transformations |
McNamara, KR, Newman, et al |
International Organization |
Commentary/Editorial| Commentaire/Éditorial |
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Ostracizing Children from Research in COVID-19: Is it Ethical? |
Meena, J, Yadav, et al |
Indian J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Meng, W, Rosenfeld, et al |
Cell Host Microbe |
Commentary/Editorial| Commentaire/Éditorial |
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A chimeric being from Kyushu, Japan: Amabie's revival during Covid-19 |
Merli, C |
Anthropology Today |
Commentary/Editorial| Commentaire/Éditorial |
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Meyer, BC, Friedman, et al |
Telemed J E Health |
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Therapeutic options and treatment strategies against covid-19 in china |
Mia, Z, Meng, et al |
Current Organic Synthesis |
Commentary/Editorial| Commentaire/Éditorial |
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Pandemopolitics. How a public health problem become a geopolitical and geoeconomic issue |
Mionel, V, Neguț, et al |
Eurasian Geography and Economics |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 should be recognized as an occupational disease worldwide |
Moen, BE |
Occupational Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Mohd Radzi, SF, Hassan, et al |
Asia Pac J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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32979917; COVID-19 and Social Distancing: A Pandemic of Advanced Diseases Is at Birth |
Molavi Vardanjani, H, Mirzazadeh, et al |
Archives of Iranian medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Mondada, L, Bänninger, et al |
Discourse Studies |
Commentary/Editorial| Commentaire/Éditorial |
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The impact of the coronavirus disease 2019 pandemic on a central Italy transplant center |
Montalbano, M, Levi Sandri, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Near-patient SARS-CoV-2 molecular platforms: new-old tools for new-old problems |
Moore, LukeSP |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Moris, Dimitrios, Tsilimigras, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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18th Annual Meeting of the International Society for Stem Cell Research (ISSCR) |
Moscoso-Castro, M |
Drugs of the Future |
Commentary/Editorial| Commentaire/Éditorial |
|
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Analysis of global research trends in coronaviruses: A bibliometric investigation |
Mukherjee, B |
Journal of Scientometric Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Radiology practice in sub-Saharan Africa during the COVID-19 outbreak: Points to consider |
Mutala, TM, Onyambu, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Nasonov, EL, Beketova, et al |
Nauchno-Prakticheskaya Revmatologiya |
Commentary/Editorial| Commentaire/Éditorial |
|
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Nath, KA |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
|
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Nauck, MA, Meier, et al |
Diabetes care |
Commentary/Editorial| Commentaire/Éditorial |
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Nayarisseri, A |
Current Topics in Medicinal Chemistry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ng, Z, Tay, et al |
European Respiratory Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Nicastri, Emanuele, D’Abramo, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
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Perceived Impacts of the COVID-19 Pandemic on Pediatric Care in Canada: A Roundtable Discussion |
Nicholas, DB, Belletrutti, et al |
Global Pediatric Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Nicolini, H |
Cirugia y Cirujanos (English Edition) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Nie, K, Yang, et al |
World Journal of Clinical Cases |
Commentary/Editorial| Commentaire/Éditorial |
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How does the COVID-19 cause seizure and epilepsy in patients? The potential mechanisms |
Nikbakht, F, Mohammadkhanizadeh, et al |
Multiple Sclerosis and Related Disorders |
Commentary/Editorial| Commentaire/Éditorial |
|
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32979916; Adverse Impact of Sanctions on Control of COVID-19 Epidemic in Iran |
Nikpajouh, A, Ahadi, et al |
Archives of Iranian medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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A How-to Guide to Building a Robust SARS-CoV-2 Testing Program at a University-Based Health System |
Nimer, SD, Chapman, et al |
Academic Pathology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Clinical research during the COVID-19 pandemic: Gastroenterology researchers' perspective |
Niriella, MA, De Silva, et al |
Frontline Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Who complies with COVID-19 transmission mitigation behavioral guidelines? |
Nofal, AM, Cacciotti, et al |
PLoS One |
Commentary/Editorial| Commentaire/Éditorial |
|
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The economic risk from COVID-19 in Pacific Island countries: very few infections but lots
of pain |
Noy, I, Doan, et al |
New Zealand Economic Papers |
Commentary/Editorial| Commentaire/Éditorial |
|
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Nuñez, JH, Porcel, et al |
Injury |
Commentary/Editorial| Commentaire/Éditorial |
|
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Assessing via Simulation the Operating Characteristics of the WHO Scale for COVID-19 Endpoints |
O’Kelly, M, Li, et al |
Statistics in Biopharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Testing partnership and preparedness in Northern Ireland during COVID-19 |
O’Rourke, M, Maguire, et al |
Social Work Education |
Commentary/Editorial| Commentaire/Éditorial |
|
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Recombining place: COVID-19 and community action networks in South Africa |
Odendaal, N |
International Journal of E-Planning Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 Pandemic and Informal Urban Governance in Africa: A Political Economy Perspective |
Onyishi, CJ, Ejike-Alieji, et al |
Journal of Asian and African Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
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Oransirikul, T, Takada, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
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Ornellas, A, Engelbrecht, et al |
Social Work (South Africa) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Hydroxychloroquine and dexamethasone in COVID-19: Who won and who lost? |
Ortolani, C, Pastorello, et al |
Clinical and Molecular Allergy |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ovchinnikov, S |
Victims and Offenders |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pathak, KP, Gaire, et al |
Kathmandu University Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mechanisms and treatments of myocardial injury in patients with corona virus disease 2019 |
Peng, W, Wu, et al |
Life Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pessato, M |
Comunicazione Politica |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: Contact and gesture monitoring using PROUD Technology |
Pietroiusti, A, Uva, et al |
Occupational Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pinchi, V, Brambilla, et al |
Dental Cadmos |
Commentary/Editorial| Commentaire/Éditorial |
|
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Home care for non-Covid-19 patients in the Covid era: Three different experiences |
Pinna, MÁC, Aguilar, et al |
Medicina Paliativa |
Commentary/Editorial| Commentaire/Éditorial |
|
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Study of critically ill patients with COVID-19 in New York City |
Piovani, Daniele, Bonovas, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
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Plog, J, Wu, et al |
Physics of Fluids |
Commentary/Editorial| Commentaire/Éditorial |
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Ética médica
y Covid-19. Comisión de Ética Sociedad de Médicos Hospital de Caracas |
Poleo, JR |
Gaceta medica de Caracas |
Commentary/Editorial| Commentaire/Éditorial |
|
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SMEs debt financing in the EU: On the eve of the coronacrisis |
Polishchuk, Y, Kornyliuk, et al |
Banks and Bank Systems |
Commentary/Editorial| Commentaire/Éditorial |
|
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Popescu Ljungholm, D, Olah, et al |
Review of Contemporary Philosophy |
Commentary/Editorial| Commentaire/Éditorial |
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32961115; “You saved my life.”—A Trainee's Reflection on COVID-19 and Social Justice |
Quan, AV, Patel, et al |
American Journal of Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
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Quispe Flores, MA, Concepción Zavaleta, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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32971027; Resident Perspectives on COVID-19: Three Takeaways |
Ramirez, DA, Dawoud, et al |
American Journal of Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Mental health consequences of the COVID-19 pandemic associated with social isolation |
Ramírez-Ortiz, J, Castro-Quintero, et al |
Colombian Journal of Anesthesiology |
Commentary/Editorial| Commentaire/Éditorial |
|
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PMC7508049; Lancet gate: a matter of fact or a matter of concern |
Raoult, D |
New Microbes New Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
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Rassouli, M, Ashrafizadeh, et al |
Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Razai, MS, Kankam, et al |
Journal of Primary Care and Community Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Regazzoni, V, Loffi, et al |
Circulation journal : official journal of the Japanese Circulation Society |
Commentary/Editorial| Commentaire/Éditorial |
|
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32978341; Community action for people with HIV and sex workers during the COVID-19 pandemic in
India |
Reza-Paul, S, Lazarus, et al |
WHO South-East Asia journal of public health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Richardson, MA, Islam, et al |
Geriatric Orthopaedic Surgery and Rehabilitation |
Commentary/Editorial| Commentaire/Éditorial |
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Riggs, J, McGowan, et al |
Canadian Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pandemic-driven technology adoption: Public decision makers need to tread cautiously |
Robinson, P, Johnson, et al |
International Journal of E-Planning Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Management of autoimmune disease during the COVID-19 pandemic |
Robinson, PC, Bursle, et al |
Australian Prescriber |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 Tourism impacts in South Africa: Government and industry responses |
Rogerson, CM, Rogerson, et al |
Geojournal of Tourism and Geosites |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 and tourism spaces of vulnerability in South Africa |
Rogerson, CM, Rogerson, et al |
African Journal of Hospitality, Tourism and Leisure |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ross, M, Singh, et al |
Occupational Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Rothman, JA, Loveless, et al |
Microbiol Resour Announc |
Commentary/Editorial| Commentaire/Éditorial |
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Roztocki, N, Strzelczyk, et al |
Information Systems Management |
Commentary/Editorial| Commentaire/Éditorial |
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Rubio, MC, Sanchez, et al |
Seminars in oncology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ruiz Estrada, Mario Arturo |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
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Russill, C |
Canadian Journal of Communication |
Commentary/Editorial| Commentaire/Éditorial |
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From Justice to the Good? Liberal Utilitarianism, Climate Change and the Coronavirus Crisis |
Rydenfelt, H |
Camb Q Healthc Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
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Saka, MC |
Klinik Psikiyatri Dergisi |
Commentary/Editorial| Commentaire/Éditorial |
|
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Santana, C |
Hist Philos Life Sci |
Commentary/Editorial| Commentaire/Éditorial |
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Sargsyan, K, Lin, et al |
Chemical Science |
Commentary/Editorial| Commentaire/Éditorial |
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Political publics: La TV ai tempi del COVID-19. Cosa è cambiato? |
Scaglioni, M, Sfardini, et al |
Comunicazione Politica |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 contact tracing: From local to global and back again |
Scassa, T |
International Journal of E-Planning Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Future aircraft turnaround operations considering post-pandemic requirements |
Schultz, M, Evler, et al |
Journal of Air Transport Management |
Commentary/Editorial| Commentaire/Éditorial |
|
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Schwartz, DA, Thomas, et al |
EBioMedicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Scott, J |
British Journal of Occupational Therapy |
Commentary/Editorial| Commentaire/Éditorial |
|
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Scott, PF |
Edinburgh Law Review |
Commentary/Editorial| Commentaire/Éditorial |
|
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Reply to John spry on stay-at home
orders and COVID-19 hospitalizations |
Sen, S, Karaca-Mandic, et al |
Econ Journal Watch |
Commentary/Editorial| Commentaire/Éditorial |
|
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32961114; Importance of Patient Advocacy During the COVID-19 Pandemic |
Sengillo, JD |
American Journal of Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
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Seo, Y, Daimon, et al |
Journal of Echocardiography |
Commentary/Editorial| Commentaire/Éditorial |
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Serlachius, A, Schache, et al |
JMIR Res Protoc |
Commentary/Editorial| Commentaire/Éditorial |
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Shanbhag, NM, Duncan, et al |
Oncologist |
Commentary/Editorial| Commentaire/Éditorial |
|
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35th Annual European Association of Urology (EAU) congress: Virtual meeting - July 17-19,
2020 |
Sharman, R |
Drugs of the Future |
Commentary/Editorial| Commentaire/Éditorial |
|
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Shaw, JA, Sethi, et al |
npj Digital Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Undermining breastfeeding will not alleviate the COVID-19 pandemic |
Shenker, NatalieS, Wesolowska, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
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Shepherd, DA |
Journal of Management Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Shiple, C, Eamranond, et al |
J Forensic Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
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Revisiting
strategies for maternal health care in the face of COVID-19 pandemic |
Shrestha, N, Dangal, et al |
Kathmandu University Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Telehealth treatment engagement with Latinx populations during the COVID-19 pandemic |
Silva, MichelleA, Perez, et al |
The Lancet Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Cardiac Affection in a Young Girl with Post Covid-19 Kawasaki Like Syndrome |
Singhi, AK, Mohapatra, et al |
Indian J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
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Leisure in times of COVID-19: reflection on Hong Kong and Israel |
Sivan, A |
World Leisure Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Skorinko, JLM, Incollingo Rodriguez, et al |
Policy Insights from the Behavioral and Brain Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Smyth, SJ |
Global Food Security |
Commentary/Editorial| Commentaire/Éditorial |
|
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Soares, WB, Silvestre, et al |
Frontiers in Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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A physiological link for psychiatric symptoms in COVID-19: Role of amino acid deficiency |
Soni, VK, Sharma, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Steier, J, Durrant, et al |
Journal of Thoracic Disease |
Commentary/Editorial| Commentaire/Éditorial |
|
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Steinbauer, M, Böckler, et al |
Gefasschirurgie |
Commentary/Editorial| Commentaire/Éditorial |
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Stileman, K, Nyren, et al |
Journal of Scholarly Publishing |
Commentary/Editorial| Commentaire/Éditorial |
|
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Streimikiene, D, Korneeva, et al |
Terra Economicus |
Commentary/Editorial| Commentaire/Éditorial |
|
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Struwig, J, Roberts, et al |
International Journal of Sociology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Contact tracing Trump's travels would be 'massive but feasible' |
Subbaraman, N |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sun, S, Ravintharan, et al |
ANZ J Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
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Recommendations of the Polish Ophthalmological Society for contact-lens wearers in the COVID-19 era* |
Szaflik, JP, Horban, et al |
Klinika oczna |
Commentary/Editorial| Commentaire/Éditorial |
|
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Taber, E |
Journal of Scholarly Publishing |
Commentary/Editorial| Commentaire/Éditorial |
|
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Covid 19: NEJM and former CDC director launch stinging attacks on US response |
Tanne, JH |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
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Foreword from the General
Chairs (Or How COVID-19 Almost Spoiled a Perfect Plan) |
Tentori, M, Weibel, et al |
|
Commentary/Editorial| Commentaire/Éditorial |
|
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Principles Learned from the International Race to Develop a Safe and Effective COVID-19 Vaccine |
Thames, AH, Wolniak, et al |
ACS Central Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Lancet Infectious, Diseases |
The Lancet Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
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The, Lancet |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
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Thiara, S, Henry, et al |
British Columbia Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Thompson, A, Morgan, et al |
Pract Neurol |
Commentary/Editorial| Commentaire/Éditorial |
|
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Tomasini, F |
Camb Q Healthc Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
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Tomé, P |
Anthropology Today |
Commentary/Editorial| Commentaire/Éditorial |
|
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Tredinnick, L, Laybats, et al |
Business Information Review |
Commentary/Editorial| Commentaire/Éditorial |
|
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Trisolino, G, Origo, et al |
Ital J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
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Trnka, S |
Anthropology Today |
Commentary/Editorial| Commentaire/Éditorial |
|
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Student tuition during COVID-19: Two personal experiences from the first online semester 2020 |
Troidl, K, Simon, et al |
Gefasschirurgie |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tsai, CTL |
World Leisure Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Tuka, V, Sovová, et al |
Cor et vasa |
Commentary/Editorial| Commentaire/Éditorial |
|
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Emergency management and internal audit of emergency preparedness of pre-hospital emergency care |
Tušer, I, Bekešienė, et al |
Quality and Quantity |
Commentary/Editorial| Commentaire/Éditorial |
|
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Role of monoclonal antibody drugs in the treatment of COVID-19 |
Ucciferri, C, Vecchiet, et al |
World Journal of Clinical Cases |
Commentary/Editorial| Commentaire/Éditorial |
|
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The Impact of the Use of Biological Weapons in Warfare: COVID-19 as a Glimpse |
Udowoima, Memabasi, Udongwo, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Underwood, BR, Thompsell, et al |
Aging Ment Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Infections and diabetes: Risks and mitigation with reference to India |
Unnikrishnan, R, Misra, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Commentary/Editorial| Commentaire/Éditorial |
|
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Gustatory Dysfunction: A Highly Specific and Smell-Independent Symptom of COVID-19 |
Vaira, LA, Lechien, et al |
Indian Journal of Otolaryngology and Head and Neck Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
van Klaveren, CW, de Jong, et al |
J Med Internet Res |
Commentary/Editorial| Commentaire/Éditorial |
|
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Leisure will not be locked down–insights on leisure and COVID-19 from the Netherlands |
van Leeuwen, M, Klerks, et al |
World Leisure Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Marketing of breastmilk substitutes during the COVID-19 pandemic |
van Tulleken, Christoffer, Wright, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32914751; Suffering in end-of-life patients in the COVID-19 era |
Vasconcelos, A, Azevedo, et al |
Acta Medica Portuguesa |
Commentary/Editorial| Commentaire/Éditorial |
|
|
How should we respond to the life-altering crises that education is facing? |
Veletsianos, G |
Distance Education |
Commentary/Editorial| Commentaire/Éditorial |
|
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Gastrointestinal cancer pathways may breakdown due to COVID-19 |
Verma, AM, Nagpal, et al |
Frontline Gastroenterology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Sustainable development of society in the context of the transformation of the legal framework |
Vilks, A, Kipāne, et al |
European Journal of Sustainable Development |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Vinson, V |
Science |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
von Waldstein, G, Grimbacher, et al |
Internistische Praxis |
Commentary/Editorial| Commentaire/Éditorial |
|
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Vrazo, AC, Golin, et al |
Journal of the International AIDS Society |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mechanisms linking the human gut microbiome to prophylactic and treatment strategies for COVID-19 |
Walton, GE, Gibson, et al |
Br J Nutr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Warnet, S |
Revue de l'infirmiere |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Wells, AI, Coyne, et al |
Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Students' Experiences With Racism During the COVID-19 Pandemic |
Wilby, KJ, Chun, et al |
Acad Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wilkie, M |
Peritoneal Dialysis International |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Williams, N |
Occupational Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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More Than Just Hard Work: Educational Policies to Facilitate Economic Mobility |
Williams, WR, Reppond, et al |
Policy Insights from the Behavioral and Brain Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lessons learned from COVID-19 for the post-antibiotic future |
Wilson, LA, Rogers Van Katwyk, et al |
Global Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wiwanitkit, V |
Neth Heart J |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Wójcik, D |
Progress in Human Geography |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Wood, BR, Young, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yang, Z, Wu, et al |
Journal of Thoracic Disease |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yarlagadda, BB, Anderson, et al |
JAMA Otolaryngol Head Neck Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32979915; COVID-19: The Challenge of Disadvantaged Groups and their Access to Care |
Zanganeh, M, Moradi, et al |
Archives of Iranian medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zhang, T |
Iranian Journal of Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Research progress of new coronavirus SARS-CoV-2 detection technology |
Zhang, XY, Zhang, et al |
Progress in Biochemistry and Biophysics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mental health and the medical profession during the COVID-19 pandemic |
Zhou, AY, Panagioti, et al |
Occupational Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ambulatory TAVR: Early Feasibility Experience During the COVID-19 Pandemic |
Zouaghi, O, Wintzer-Wehekind, et al |
CJC Open |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Transitioning to a New Era: Future Directions for Staff Development during COVID-19 |
Zuo, L, Miller Juvé, et al |
Med Educ |
Commentary/Editorial| Commentaire/Éditorial |
|
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PMC7489452; UK policy targeting obesity during a pandemic - the right approach? |
|
Nat Rev Endocrinol |
Commentary/Editorial| Commentaire/Éditorial |
|
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Occupational Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Oncology (Williston Park, N.Y.) |
Commentary/Editorial| Commentaire/Éditorial |
|
Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro,
attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease
process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro), les taux d'attaque,
le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies humaines, dans
le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives