*There was a misalignment in the table yesterday. Apologies for resending with a corrected table.
There are 1043 citations in today’s scan. 516 were considered primary research or review literature.
Highlights today include:
CANADA
·
Chan,
J. This article analyzes which characteristics are correlated with mobility reductions during the COVID-19 pandemic, using census-division-level mobility data for Canada from Facebook.
EPIDEMIOLOGY
·
Speake et al investigate potential transmission of SARS-CoV-2
during a domestic flight within Australia. Eleven passengers with PCR-confirmed SARS-CoV-2 infection and symptom onset within 48 hours of the flight were considered infectious during travel; 9 had recently disembarked
from a cruise ship with a retrospectively identified SARS-CoV-2 outbreak. The virus strain of those on the cruise and the flight was linked (A2-RP) and had not been previously identified in Australia. For 11 passengers,
none of whom had traveled on the cruise ship, PCR-confirmed SARS-CoV-2 illness developed between 48 hours and 14 days after the flight. This investigation provides evidence of flight-associated SARS-CoV-2 transmission.
·
Hausler et al.
Children, compared with adults children are less affected by SARS‐CoV‐2 infections and are unlikely to account for the initial viral spread. However, children show sustained viral activity and may serve as a viral reservoir.
VACCINE
·
Anderson et al published the results of their Phase 1 vaccine trial in NEJM. Conducted dose-escalation, open-label
trial of a messenger RNA vaccine, mRNA-1273 in healthy adults which was expanded to include 40 older adults, who were stratified according to age (56 to 70 years or ≥71 years). Solicited adverse events were predominantly mild or moderate in severity. Binding-antibody
responses increased rapidly after the first immunization. By day 57, among the participants who received the 25-μg dose, the anti-S-2P geometric mean titer (GMT) was 323,945 among those between the ages of 56 and 70 years and 1,128,391 among those who were
71 years of age or older; among the participants who received the 100-μg dose, the GMT in the two age subgroups was 1,183,066 and 3,638,522, respectively. The 100-μg dose induced higher binding- and neutralizing-antibody titers than the 25-μg dose, which supports
the use of the 100-μg dose in a phase 3 vaccine trial.
CLINICAL DATA
·
Edén et al. explored whether hospitalized patients with SARS-CoV-2 and neurologic
symptoms have evidence of CNS infection, inflammation and injury using CSF biomarker measurements. Results suggest an unusual pattern of marked CSF inflammation in which soluble markers were increased but white cell response and other immunologic features
typical of CNS viral infections were absent. While our initial hypothesis centered on CNS SARS-CoV-2 invasion, we could not convincingly detect SARS-CoV-2 as the underlying driver of CNS inflammation. These features distinguish COVID-19 CSF from other viral
CNS infections, and raise fundamental questions about the CNS pathobiology of SARS-CoV-2 infection
·
Zhao W et. al. This retrospective study analyzed 56 COVID-19 cases from two
institutions in Hunan province, China in order to investigate the relationship between clinical characteristics, radiographic features, and the viral load of patients with coronavirus disease 2019 (COVID-19). GGO (48, 85.7%) and vascular enlargement (44, 78.6%)
were the most frequent signs in COVID-19 patients. The viral load of COVID-19 is negatively correlated with an uneasily differentiated lesion margin on initial CT scan images and the Ct value should noted when making a diagnosis. In addition, following-up
CT scans are necessary for patients who presented a normal CT at the initial diagnosis, especially for those with a low Ct value.
·
Vassiliou et al followed 45 patients with COVID-19 pneumonia and assessed the effects of blood lactate
levels. They found that initial blood lactate was an independent outcome predictor in COVID-19 ICU patients.
·
Wang et al. performed a retrospective cohort study at Boston Medical
Center between April 1, 2020 and July 22, 2020 to compare the outcomes of pregnant women with and without COVID-19. Women with a COVID-19 diagnosis at their time of delivery were significantly more likely to identify as a race other than white (p = 0.01),
to deliver preterm (p = 0.05), to be diagnosed with preeclampsia with severe features (p < 0.01), and to require general anesthesia (p < 0.01). COVID-19 diagnosis was not associated with increased blood loss or maternal morbidity compared with pregnant women
without a COVID-19 diagnosis.
·
Lebrao, et al. report a 32-year-old pregnant woman, gestational age 37 and 3/7 weeks,
was admitted with a flu-like syndrome caused by COVID-19. The female newborn was appropriate for gestational age. Anti-SARS-CoV-2 Immunoglobulin A was detected in the two samples of breastmilk evaluated, whose values were 2.5 and 1.9, respectively. No anti-SARSCoV-2
immunoglobulin G was detected. The exclusively-breastfed infant remained well through 45 days of age.
RECCURENCE
·
Hu et al. prospectively analyzed 117 hospitalized patients with mild pneumonia in Wuhan.
Eight patients (6.8%) showed a re‐positive test after a median of 12.5 (11.8‐16.3) days. Seven of them were asymptomatic. No new transmission has been observed.
IMMUNOLOGY/ SEROLOGY
·
Pascolini et al analyzed the presence and role of autoantibodies in patients with COVID‐19‐associated
pneumonia. They prospectively studied 33 consecutive patients with COVID‐19, 31 (94%) of whom had interstitial pneumonia. They observed that autoantibodies are frequently detected in patients with COVID‐19 possibly reflecting a pathogenetic role of immune
dysregulation.
·
Faccini-Martínez et al. found 26% of serological cross-reactivity
in patients with acute Zika virus infection using a commercial SARS-CoV-2 ELISA test.
·
Liu et al present the principle and procedure of developing a colloidal gold immunochromatographic
assay (GICA) for rapid detection of COVID-19-specific antibodies. Based on analysis from 375 samples, they calculated the overall sensitivity and specificity of the assay to be 95.85% and 97.47%, respectively.
·
Nelde et al. characterize multiple dominant and subdominant SARS-CoV-2 HLA class I and HLA-DR peptides as potential T cell
epitopes in COVID-19 convalescent and unexposed individuals.
IMMUNOLOGY – ANIMAL MODEL
·
Du et al. showed how a potent COVID-19 antibody, BD-368-2, interacts
with the SARS-CoV-2 spike trimer to neutralize the virus and effectively treat severely infected hamsters. They further demonstrated how BD-368-2 can be paired with additional antibodies to form a cocktail that prevents the evolution of viral escape mutants
·
Huang et al. reported that recombinant SARS-CoV-2 RBD protein immunization in
mice can elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.
THERAPEUTICS
·
Benjamin et al examined the efficacy and safety of Hydroxychloroquine
vs Placebo for Pre-exposure SARS-CoV-2 Prophylaxis Among Health Care Workers in a A Randomized Clinical Trial. There was no significant difference in infection rates in participants randomized to receive hydroxychloroquine compared with placebo (4 of 64 [6.3%]
vs 4 of 61 [6.6%]; P > .99). Mild adverse events were more common in participants taking hydroxychloroquine compared with placebo (45% vs 26%; P = .04); rates of treatment discontinuation were similar in both arms (19% vs 16%; P = .81). In this randomized
clinical trial, although limited by early termination, there was no clinical benefit of hydroxychloroquine administered daily for 8 weeks as pre-exposure prophylaxis in hospital-based HCWs exposed to patients with COVID-19.
·
Tian et. al.,This preprint in The Lancet is of a multicentre, retrospective, cohort
study, of 5,235 adult patients who were admitted to 3 hospitals in Wuhan, China with confirmed COVID-19. Univariable and multivariable Logistic and Cox regression models showed that follow-up patients of non-tocilizumab group were more likely to develop into
death (42 [32·31%] vs 14 [21·54%]). The detected risk for in-hospital death was lower in the tocilizumab group versus the non-tocilizumab group (HR=0·47; 95% CI=0·25-0·90; p=0·023). In the multivariable logistic regression model, use of tocilizumab was associated
with a lower risk of ARDS (OR=0 · 23; 95% CI=0·11-0·45; p<0·0001). Tocilizumab may be of value in improving outcomes in severe patients of COVID-19, which provided a novel strategy for COVID-19-induced cytokine release syndrome (CRS).
·
Clayton et al.
In a pilot trial of 5 oxygen‐dependent elderly patients with COVID‐19 pneumonia, low‐dose whole‐lung radiation led to rapid improvements in clinical status, encephalopathy, and radiographic consolidation without acute toxicity.
Low‐dose whole‐lung radiation appears to be safe, shows early promise of efficacy, and warrants further study.
·
Fintelman-Rodrigues et al. find that atazanovir docks in the active site of SARS-CoV-2 Mpro with greater
strength than LPV, blocking Mpro activity. We confirmed that ATV inhibits SARS-CoV-2 replication, alone or in combination with ritonavir (RTV) in Vero cells and a human pulmonary epithelial cell line. ATV/RTV also impaired virus-induced enhancement of interleukin
6 (IL-6) and tumor necrosis factor alpha (TNF-a) levels. Together, our data strongly suggest that ATV and ATV/RTV should be considered among the candidate repurposed drugs undergoing clinical trials in the fight against COVID-19
·
Zhao J et. al. A systems pharmacology strategy was proposed to investigate
the mechanisms of QFPDD against COVID-19 from molecule, pathway and network levels by use of text mining, target prediction, data integration, network study, bioinformatics analysis, molecular docking, and pharmacological validation. 623 high-confidence targets
of QFPDD's 12 active compounds were identified, 88 of which were overlapped with genes affected by SARS-CoV-2 infection. Comprehensive network and pathway analysis were used to identify 55 important targets, 5 immune regulators, 6 host proteins that interact
with SARS-CoV-2 proteins that have anti-viral function, inhibition of 6 cytokines, and upregulation of IL-10. This work illustrated that QFPDD could exhibit immune regulation, anti-infection, anti-inflammation, and multi-organ protection.
THERAPEUTICS- ANIMAL MODEL
·
Lu et al investigated the therapeutic effects of SSK1, a β-galactosidase (β-gal)-activated
prodrug, in SARS-CoV-2-infected nonhuman primate model. SSK1 efficiently mitigated clinical symptoms and pathologically reduced SARS-CoV-2-infected pneumonia, and there was a reduction in macrophage infiltration in the lungs of SSK1-treated animals. Targeting
macrophages by SSK1 could be a promising strategy to control inflammation in COVID-19 treatment.
PUBLIC HEALTH INTERVENTIONS
·
Gagnon, L. J., Gagnon, S., Lloyd, J. utilize the quasi-experimental
setting created by the nationwide protests precipitated by George Floyd’s tragic death on May 25, 2020, to assess the causal impact of social distancing on the spread of SARS-CoV-2. Methods: Our sample period spans from January 22, 2020, to June 20, 2020,
and consists of 474,422 county-days representing 3,142 counties from all 50 states and the District of Columbia. Findings: We document a country-wide increase of over 3 · 06 cases per day, per 100,000 population, following the onset of the protests and a
further increase of 1 · 73 cases per day, per 100,000 population, in the counties in which the protests took place ). Relative to the week preceding the onset of the protests, this represents a 61 · 2 % country-wide increase in the infection rate, and a further
34 · 6 % increase in the protest counties.
·
Li, et al. used county-level mobility data as a measure of a community’s voluntary
compliance with social distancing policies, this study found that counties who received strong state social distancing policy directives and who had a high pro-social character showed lower mobility (better social distancing) after states reopened from shelter-in-place
orders. Counties that experienced a longer duration of shelter-in-place orders showed higher mobility (less social distancing).
·
Atefe Darabi, Milad Siami
This study aims to highlight the effect of time-delay in the progress of such infectious diseases in the meta-population networks rather than individuals or a single population. The numerical results, along with the theoretical
expectations, highlight the impact of time-delay as well as the importance of considering the worst-case scenarios in investigating the most effective methods of epidemic containment.
FACE MASKS
·
Hill et al. Findings suggest that parameters including permeability and pliability can play
a strong role in the filtration efficiency of a mask fabricated with various filter media, and that the filtration efficiency of loosely fitting masks/respirators against ultrafine particulates can drop by more than 60% when worn compared to the ideal filtration
efficiency of the base material. Further, a test method using SARSCoV-2 virion-sized silica nanoaerosols is demonstrated to assess the filtration efficiency against nanoparticulates that follow air currents associated with mask leakage.
·
Sharma
et al show that a single layer of a surgical mask can atomize a cough droplet into numerous tiny droplets. The single-layer masks were found to be ineffective in restraining cough droplets while no penetration could be noticed for a triple-layer
mask. A single-layer or double-layer face mask causes atomization of the droplets resulting in the formation of larger number of droplets with smaller sizes. These tiny droplets can aerosolize in the immediate environment and can remain suspended for a longer
time.
SOCIETY KNOWLEDGE, ATTITUDES AND BELIEFS
·
Papa and Maniou assess dominant narratives generated through
users’ reactions towards news content posted on Facebook so as to examine the role of Facebook during the global crisis of COVID-19. Three categories emerge from the analysis; the first category corresponds to “infotainment” - type information, the second
refers to raised awareness around COVID-19-related issues, while the third category suggests a more emotional construction regarding the pandemic.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Austyn Baumeister, Anam Khan, Musaab Younis,
Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin Young, Chatura Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Alex Gilbert, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
|
PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Telehealth tinnitus therapy during the COVID-19 outbreak in the UK: uptake and related factors |
Aazh, H, Swanepoel, et al |
Int J Audiol |
Public Health response| Interventions de santé publique Healthcare Response | Réponse des soins de santé |
During COVID-19 lockdown, patients were offered telehealth cognitive behavioural therapy (CBT) for tinnitus rehabilitation
via video using a web-based platform. This study evaluated the proportion of patients who took up the offer of telehealth sessions and factors related to this. 80% of patients accepted telehealth. The main reasons for declining were not having access to a
suitable device and the belief that telehealth appointments would not be useful. Compared to having no hearing loss in the better ear, having a mild or moderate hearing loss increased the chance of declining telehealth by factors of 3.5 (p = 0.04) and 14.9
(p = 0.038), respectively. High tinnitus annoyance as measured via the visual analogue scale increased the chance of declining telehealth appointments by a factor of 1.4 (p = 0.019). |
|
Abdelrheem, DA, Ahmed, et al |
J Environ Sci Health A Tox Hazard Subst Environ Eng |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This work aimed at evaluating the inhibitory effect of ten natural bioactive compounds (1-10) as potential inhibitors of SARS-CoV-2-3CL main protease (PDB
ID: 6LU7) and SARS-CoV main proteases (PDB IDs: 2GTB and 3TNT) by molecular docking analysis. Based on molecular docking analysis, the study found that caulerpin has the highest binding affinity inside all studied receptors compared to other bioactive compounds
and studied drugs. The homology modeling and sequence alignment showed that SARS-CoV main protease (PDB ID: 3TNT) shares high similarity with 3CLpro (96.00%). Also, ADMET properties confirmed that caulerpin obeys Lipinski's rule and passes ADMET property,
which make it a promising compound to act as a new safe natural drug against SARS-CoV-2-3CL main protease. Finally, MD simulation confirmed that the complex formed between caulerpin and 3CLpro is stable in water explicit and had no major effect on the flexibility
of the protein throughout the simulations and provided a suitable basis for our study. Also, binding free energy between caulerpin and 6LU7 confirmed the efficacy of the caulerpin molecule against SARS-CoV-2 main protease. |
|
|
Abella, BS, Jolkovsky, et al |
JAMA Intern Med |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
This randomized, double-blind, placebo-controlled clinical trial (the Prevention and Treatment of COVID-19 With Hydroxychloroquine Study) was conducted
at 2 tertiary urban hospitals, with enrollment from April 9, 2020, to July 14, 2020; follow-up ended August 4, 2020. And evaluated the efficacy of hydroxychloroquine to prevent transmission of SARS-CoV-2 in hospital-based HCWs with exposure to patients with
COVID-19 using a pre-exposure prophylaxis strategy. Of the 132 randomized participants (median age, 33 years range, 20-66 years]; 91 women 69%]), 125 (94.7%) were evaluable for the primary outcome. There was no significant difference in infection rates in
participants randomized to receive hydroxychloroquine compared with placebo (4 of 64 6.3%] vs 4 of 61 6.6%]; P > .99). Mild adverse events were more common in participants taking hydroxychloroquine compared with placebo (45% vs 26%; P = .04); rates of treatment
discontinuation were similar in both arms (19% vs 16%; P = .81). The median change in QTc (baseline to 4-week evaluation) did not differ between arms (hydroxychloroquine: 4 milliseconds; 95% CI, -9 to 17; vs placebo: 3 milliseconds; 95% CI, -5 to 11; P = .98).
Of the 8 participants with positive results for SARS-CoV-2 (6.4%), 6 developed viral symptoms; none required hospitalization, and all clinically recovered. |
|
|
Abid, Nabil, Chillemi, et al |
ArXiv |
Coronavirology| Coronavirologie |
In this paper the authors address a new hypothesis, based on a possible recombination between a DNA and SARS-CoV viruses, to explain the rise of SRAS-CoV-2.
By comparing SARS-CoV-2 and related CoVs with circoviruses (CVs), the study found strong sequence similarity of the genomic region at the 3-end of Bat-CoV ORF1a and the origin of replication (Ori) of porcine CV type 2 (PCV2), as well as similar RNA secondary
structures of the region encompassing the cleavage site of CoV S gene with the PCV2 Ori. This constitutes a primary evidence that supports a possible recombination, which occurrence might explain the origin of SARS-CoV-2. |
|
|
Multiple early introductions of SARS-CoV-2 into a global travel hub
in the Middle East |
Abou Tayoun, Ahmad, Loney, et al |
bioRxiv |
Epidemiology| Épidémiologie Transmission Coronavirology| Coronavirologie |
Using data from Dubai in the United Arab Emirates (UAE), a major international travel hub in the Middle East, the authors establish SARS-CoV-2 full genome
sequences from the index and early COVID-19 patients in the UAE. The genome sequences are analyzed in the context of virus introductions, chain of transmissions, and possible links to earlier strains from other regions of the world. Phylogenetic analysis showed
multiple spatiotemporal introductions of SARS-CoV-2 into the UAE from Asia, Europe, and the Middle East during the early phase of the pandemic. Also providde evidence for early community-based transmission and catalogue new mutations in SARS-CoV-2 strains
in the UAE. These findings contribute to the understanding of the global transmission network of SARS-CoV-2. |
|
Adekiigbe, R, Ugbode, et al |
Am J Case Rep |
Clinical data| Données cliniques |
This report presents the case of a 47-year-old Hispanic man who developed cutaneous vasculitic lesions and gangrene
of the toes following admission to hospital with COVID-19 pneumonia. Despite anticoagulation initiated on admission in the presence of an elevated D-dimer, the patient developed gangrene of all his toes, which required bilateral transmetatarsal amputation.
This case shows that dermatologic manifestations may develop in patients who initially present with COVID-19 pneumonia. These symptoms may be due to venous thrombosis following SARS-CoV-2 vasculitis, leading to challenging decisions regarding anticoagulation
therapy. |
|
|
Adem, Ş, Eyupoglu, et al |
Phytomedicine |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study evaluated the anti-viral efficacy of natural bioactive entities against COVID-19 via molecular docking and
molecular dynamics simulation. The results produced have uncovered khainaoside C, 6-O-Caffeoylarbutin, khainaoside B, khainaoside C and vitexfolin A as potent modulators of COVID-19 possessing more binding energies than nelfinavir against COVID-19 Mpro, Nsp15,
SARS-CoV-2 spike S2 subunit, spike open state and closed state structure respectively. While Calceolarioside B was identified as pan inhibitor, showing strong molecular interactions with all proteins except SARS-CoV-2 spike glycoprotein closed state. The results
are supported by 20 ns molecular dynamics simulations of the best complexes. This study paves a way for development of phytonutrients-based antiviral therapeutic for treatment or prevention of COVID-19. |
|
|
Afshar, P, Heidarian, et al |
Pattern Recognit Lett |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Healthcare
Response | Réponse des soins de santé |
The paper presents an alternative modeling framework based on Capsule Networks, referred to as the COVID-CAPS, being
capable of handling small datasets, which is of significant importance due to sudden and rapid emergence of COVID-19. The results based on a dataset of X-ray images show that COVID-CAPS has advantage over previous Convolutional Neural Networks (CNNs)-based
models. COVID-CAPS achieved an Accuracy of 95.7%, Sensitivity of 90%, Specificity of 95.8%, and Area Under the Curve (AUC) of 0.97, while having far less number of trainable parameters in comparison to its counterparts. To potentially and further improve diagnosis
capabilities of the COVID-CAPS, pre-training and transfer learning are utilized based on a new dataset constructed from an external dataset of X-ray images. |
|
|
Perceived risk and protective behaviors regarding COVID-19 among
Iranian pregnant women |
Aghababaei, S, Bashirian, et al |
Middle East Fertility Society Journal |
Public Health response| Interventions de santé publique |
This cross-sectional study investigated the perceived risk and protective behaviors regarding COVID-19 among pregnant
women, in Hamadan, Iran. 93.8% of pregnant women had a high level of knowledge, 97.3% had a high performance in protective behaviors, and 72.9% had a moderate level of risk perception related to COVID-19. The highest mean score of knowledge was observed in
women who had a history of influenza in their previous pregnancies (90.97 ± 5.94). The mean score of protective behaviors was significantly higher in women with a high economic level (97.78 ± 5.11), and the highest level of risk perception was observed in
nulliparous women (59.97 ± 9.80). Risk perception was an independent predictor of protective behaviors related to COVID-19 (P < 0.05). |
|
Ajibo, H |
Social Work in Public Health |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
This study is designed to investigate the effect of Covid-19 on the socioeconomic well-being of Nigerians, the health
sector preparedness to handle the pandemic, and the role of Nigerian social workers in the fight against Covid-19 in Nigeria. The result of the study shows that the Covid-19 pandemic has had a devastating impact on the socioeconomic well-being of Nigerians.
Second, the Nigerian health system is ill equipped and underprepared to handle the Covid-19 pandemic. Third, Nigerian social workers, most especially medical social workers, have played a significant role in passing out information on Covid-19 preventive measures
to the general public. |
|
|
32955901; How do arbidol and its analogs inhibit the SARS-CoV-2? |
Aktas, A, Tuzun, et al |
Bratislavske lekarske listy |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This in silico study determined whether Arbidol, the hemagglutinin esterase inhibitor used in the treatment of COVID-19,
was effective against SARS Cov-2. The similarity between hemagglutinin and spike proteins were reported due to the fact that inhibition properties of Arbidol and its 39 analogues were examined in detail against hemagglutinin esterase and spike glycoproteins.
CID 1070884 and CID 1207786 were found to be more active against hemagglutinin esterase than in Arbidol, while these compounds were inactive against spike glycoproteins. The interaction mechanism was clarified between arbidol and spike proteins. Phenylalanine,
tyrosine, glycine, lysine, and aspartic acid were found to be the headliner amino acids in the interactions between Arbidol and binding domains of spike glycoproteins in the SARS-CoV2 |
|
Alandijany, TA, El-Kafrawy, et al |
Pathogens |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In this study SARS-CoV-2 full-length spike (S) recombinant protein was utilized to develop and optimize an indirect
enzyme-linked immunoassay (ELISA) that enables a reliable detection of virus-specific IgG antibody in human sera. The performance of this assay was evaluated utilizing micro-neutralization (MN) assay as a reference test. This ELISA offers 100% sensitivity,
98.4% specificity, 98.8% agreement, and high overall accuracy. Moreover, the optical density (OD) values of positive samples significantly correlated with their MN titers. The assay specifically detects human IgG antibodies directed against SARS-CoV-2, but
not those to Middle East respiratory syndrome coronavirus (MERS-CoV) or human coronavirus HKU1 (HCoV-HKU1). |
|
|
Al-Anzi, B, Alenizi, et al |
International Journal of Environmental Research and Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This study provides an overview of the current and future trajectory, as well as the impact of COVID-19 in the world
and selected countries including the state of Kuwait. The selected countries were divided into two groups: Group A (China, Switzerland, and Ireland) and Group B (USA, Brazil, and India) based on their outbreak containment of this virus. The Group A trajectory
showed an “S” shape trend that suited a logistic function with r2 > 0.97, which is an indication of the outbreak control. The SIR models for the countries in this group showed that they passed the expected 99% end of pandemic dates. Group B, however, exhibited
a continuous increase of the total COVID-19 new cases, that best suited an exponential growth model with r2 > 0.97, which meant that the outbreak is still uncontrolled. The SIR models for the countries in this group showed that they are still relatively far
away from reaching the expected 97% end of pandemic dates. The maximum death percentage varied from 3.3% (India) to 7.2% with USA recording the highest death percentage, which is virtually equal to the maximum death percentage of the world (7.3%). The power
of the exponential model determines the severity of the country’s trajectory that ranged from 11 to 19 with the USA and Brazil having the highest values. Results from both models showed that the Group A countries contained the outbreak, whereas the Group B
countries still have not reached this stage yet. |
|
|
Aldarhami, A, Bazaid, et al |
International Journal of General Medicine |
Public Health response| Interventions de santé publique |
This study evaluated the awareness and adherence of the Saudi population to social distancing measures, such as stay-at-home.
A total of 5105 participants completed the survey 58.4% females, 66.3% young individuals (aged 18–37 years), 55.8% bachelor degree holders and 51.0% from the western region]. The Saudi MOH was the main source of information about COVID-19 for most of the participants
(78.2%). High awareness (81.3%) regarding stay-at-home was observed, associated mainly with female participants, those from the middle region and those with a high education and income. The overall implementation of social distancing was satisfactory (score
3.13/5), with 37.8% never leaving home during the stay-at-home period. Better adherence to social distancing was observed among female participants, higher degree holders and those aged over 38 years. |
|
|
Al-Dawsari, N, Abulhamayel, et al |
Int J Dermatol |
Clinical data| Données cliniques |
This editorial presents a case report of a 39‐year‐old otherwise healthy female radiologist tested positive for SARS‐CoV‐2
who suddenly developed an intensely pruritic rash over both elbows. This case add to the ongoing studies on the cutaneous manifestations of SARS‐CoV‐2. |
|
|
Almaghlouth, NK, Davis, et al |
J Med Virol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study examined the relationship between sociodemographic, clinical, and laboratory findings with mortality among
patients. Eighty (80) patients: 45 males (56.25%) and 35 females (43.75%) met the study inclusion criteria. Seven patients (8.75%) were deceased. An increase in mortality outcome was statistically significantly associated with higher average levels of IL-6
with P value (0.050), and D-dimer with P value (0.024). Bivariate logistics regression demonstrated a significant increased odds for mortality for patients with bacterial lung infections (OR: 10.83, 95%CI: 2.05 - 57.40, P=0.005) and multi-organ damage (OR:
103.50, 95%CI: 9.92 - 1079.55, P=0.001). Multivariate logistics regression showed a statistically significant association for multi-organ damage (AOR: 94.17, 95%CI: 7.39 - 1200.78, P=0.001). This study identified three main predictors for high mortality. These
include interleukin-6 (IL-6), D-dimer, and multi-organ damage. |
|
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Topp-leone odd fréchet generated family of distributions with applications to COVID-19 data sets |
Al-Marzouki, S, Jamal, et al |
CMES - Computer Modeling in Engineering and Sciences |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this article, the authors propose an extension of this odd Fréchet family (or class) of continuous distributions
in fitting data of all kinds through the so-called “Topp-Leone strategy”, aiming to improve its overall flexibility by adding a shape parameter. The main objective is to offer original distributions with modifiable properties, from which adaptive and pliant
statistical models can be derived. The paper emphasizes a special distribution with three parameters based on the exponential distribution. The related model is shown to be skillful to the fitting of various lifetime data, more or less heterogeneous. Among
all the possible applications, two data sets were considered, linked to the COVID-19 pandemic. These were daily cases confirmed and recovered in Pakistan from March 24 to April 28, 2020. The analyzes showed that the proposed model has the best fitting results
in comparison to serious challengers, including the former odd Fréchet model. |
|
Al-Rasheed, M |
Social Work in Public Health |
Public Health response| Interventions de santé publique Economics | Économie |
This cross-sectional study investigated the associations between self-reported intentions to perform protective behaviors
against COVID-19, the seven constructs of the Protection Motivation Theory PMT, trust in government, and sociodemographic factors within the general population in Kuwait. Results indicate that the scores of trust in government and the severity, vulnerability,
response efficacy, and self-efficacy subconstructs of the PMT were positively related to protective behavior intention, whereas intrinsic and extrinsic reward and response cost subconstructs were negatively associated with protective behavior intention. |
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Alston, L, Meleady, et al |
Group Processes and Intergroup Relations |
Public Health response| Interventions de santé publique |
A survey of 340 UK residents was conducted when the COVID-19 virus first reached the UK in February 2020. This study
measured past experiences of positive and negative intergroup contact with Chinese people as predictors of intergroup threat and emotions in the context of the pandemic; and how these processes in turn predicted support for discriminatory policies designed
to restrict the freedom of Chinese people in the UK. The study shows that whilst intergroup contact predicted both fear and anger towards the outgroup, the indirect effect of contact on support for Chinese restriction policies via fear was significantly stronger
than the indirect effect via anger. These findings provide a more nuanced understanding of how specific threat and emotions drive intergroup contact effects, and offer important insights for efforts to maintain positive intergroup relations in the face of
the crisis. |
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Locking down the CGRP pathway during the COVID-19 pandemic lockdown: the PandeMig study |
Altamura, C, Cevoli, et al |
Neurol Sci |
Healthcare Response | Réponse des soins de santé |
This study aimed at observing whether the COVID-19 related lockdown influenced migraine frequency and disability in
migraine patients on therapy with monoclonal antibodies inhibiting the CGRP pathway. From T-free to T-lock, the cohort displayed a reduction in Monthly migraine days (MMDs) (from 10.5 ± 7.6 to 9.8 ± 7.6, p = .024) and HIT-6 scores (from 59.3 ± 8.3 men reduced
MPI more frequently than women (p = .005). Patients beyond the first 3 months of therapy presented less often a reduction in MMDs (p = .006) and on everyday life did not affect the migraine load in patients receiving monoclonal antibodies inhibiting the CGRP
pathway. Patients in the first months of therapy experienced a greater improvement according to drug pharmacokinetics, while women more frequently needed rescue medications, possibly indicating presenteeism or cephalalgophobia. |
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Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults |
Anderson, EJ, Rouphael, et al |
N Engl J Med |
Clinical data| Données cliniques Vaccine Research| Recherche sur les vaccins |
This study conducted a phase 1, dose-escalation, open-label trial of a messenger RNA vaccine, mRNA-1273, which encodes
the stabilized prefusion SARS-CoV-2 spike protein (S-2P) in healthy adults. The trial was expanded to include 40 older adults, who were stratified according to age (56 to 70 years or ≥71 years). Adverse events associated with the mRNA-1273 vaccine were mainly
mild or moderate. Binding-antibody responses increased rapidly after the first immunization. By day 57, among the participants who received the 25-μg dose, the anti-S-2P geometric mean titer (GMT) was 323,945 among those between the ages of 56 and 70 years
and 1,128,391 among those who were 71 years of age or older; among the participants who received the 100-μg dose, the GMT in the two age subgroups was 1,183,066 and 3,638,522, respectively. After the second immunization, serum neutralizing activity was detected
in all the participants by multiple methods. The 100-μg dose induced higher binding- and neutralizing-antibody titers than the 25-μg dose, which supports the use of the 100-μg dose in a phase 3 vaccine trial. |
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Arpino, G, De Angelis, et al |
ESMO open |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé Immunology | Immunologie |
This study identified asymptomatic cases among patients receiving active cancer treatment, the Federico II University
Hospital in Naples performs rapid serological tests in addition to hospital standard clinical triage for COVID-19 infection. Overall 466 patients, negative for COVID-19 symptoms, underwent serological testing in addition to standard clinical triage. The average
age was 61 years (range 25-88 years). Most patients (190, 40.8%) had breast cancer, and chemotherapy with or without immunotherapy was administered in 323 (69.3%) patients. Overall 433 (92.9%) patients were IgG-negative and IgM-negative, and 33 (7.1%) were
IgM-positive and/or IgG-positive. Among the latter patients, 18 (3.9%), 11 (2.4%) and 4 (0.9%) were IgM-negative/IgG-positive, IgM-positive/IgG-negative and IgM-positive/IgG-positive, respectively. All 33 patients with a positive serological test, tested negative
for RT-PCR SARS-CoV-2 test. No patient in our cohort developed symptoms suggestive of active COVID-19 infection. Rapid serological testing at hospital admission failed to detect active asymptomatic COVID-19 infection. |
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Arslan, G, Yıldırım, et al |
Death Stud |
Public Health response| Interventions de santé publique |
Subjective vitality and loneliness explain how coronavirus anxiety increases rumination among college students |
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Do initial hematologic indices predict the severity of COVID-19 patients? |
Asan, A, ÜstÜndaĞ, et al |
Turk J Med Sci |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study evaluated the initial hematological findings analyzed on admission in confirmed COVID-19 patients who were
transferred to the intensive care unit (ICU), to predict possible hematological indices. The proportion of COVID-19 cases admitted to ICU was 3.9%. The median age of patients admitted to ICU was significantly higher than those who were not; (68.5 (interquartile
range (IQR); 21.5) years vs. 41.0 (IQR; 15.7) years; p <0.001). Severe cases had higher neutrophil to lymphocyte ratio (NLR) (6.6 vs 2.4; P <0.001), and monocyte to lymphocyte ratio (MLR) (0.40 vs 0.28; P=0.004) and lower platelet to lymphocyte ratio (PLR)
(180.0 vs 129.0; P <0.001) compared to that of mild or moderate patients. Among all of the parameters, the ROC curve of NLR gave us the best ability to distinguish serious patients at an early stage (AUC = 0. 819, 95% confidence interval 0.729?0.910; p<0.001).
These data showed that age, initial NLR, PLR, and LYM x PLT were associated with the severity of COVID-19 disease and patient's need for the ICU. |
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Ashkan, Keyoumars, Jung, et al |
SSRN- Lancet prepublication |
Healthcare Response | Réponse des soins de santé |
This study examined how COVID-19 challenged the neurosurgical delivery of care in a busy tertiary unit serving a socio-economically
diverse population. Also described the strategies adopted to meet these challenges. Overall, there was a reduction in neurosurgical emergency referrals by 33·6% and operations by 55·6% during the course of COVID-19. There was a significant increase in the
proportion of emergency operations performed during COVID-19 (75·2% of total, n=155) when compared to pre-COVID-19 (n=198, 43·7% of total, p<0.00001). The 30-day perioperative mortality remained low at 2·0% with the majority of patients who contracted post-operative
COVID-19 infection (n=13) having underlying medical co-morbidities and/or suffering from post-operative complications. Strategies adopted to enable this included proactively approaching the referrers to maintain lines of communications, incorporating modern
technology including telemedicine to run clinics and MDTs, restructuring patient pathways/facilities into COVID-19 positive and non-COVID-19, re-organising the staff rotas, and initiating the delivery of NHS care within private sector hospitals to increase
operative capacity. |
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Atamari-Anahui, N, Cruz-Nina, et al |
Medwave |
Epidemiology| Épidémiologie |
This study aimed to describe the frequency of cases, deaths, incidence, and case fatality rate attributed to COVID-19
in children and adolescents from Latin American and the Caribbean countries. A total of 20,757 (4.2% of all patients) cases of COVID-19 were reported in children from 0 to 19 years of age. 52.4% was in the group aged 10 to 19 years. 50.6% were male. 139 (0.26%)
deaths were reported in children from 0 to 19 years. The accumulated incidence was higher in Chile, Panama, and Peru. The cumulative incidence per 100,000 inhabitants ranged from 1.26 to 77.55 in the population from 0 to 9 years old, 1.57 to 98.84 from 10
to 19 years old, and 0.91 to 88.34 from 0 to 19 years old. The case fatality rate in children from 0 to 19 years old ranged from 0 to 9.09%. |
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Declines in Mortality Over Time for Critically Ill Adults With Coronavirus Disease 2019 |
Auld, SC, Caridi-Scheible, et al |
Crit Care Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this report, we update on mortality over time from our previous report. Despite similar comorbidities and severity
of illness throughout this time period, hospital mortality declined from a peak of 34.3% in March, to 28.4% in April, 17.9% in May, 22.1% in June, and 26.9% in July. Of note, there are 15 patients (7.1%) who remain in the ICU at the time of this letter (September
4, 2020). The proportion of patients receiving mechanical ventilation also declined, from a peak of 81.1% in March, to 64.5% in April, 44.8% in May, 58.1% in June, and 50.5% in July. However, ventilator mortality, which initially declined from 38.3% in March
to 32.0% in June, increased to 43.0% in July. |
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Aviles-Rivero, Angelica |
ArXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this work, we introduce a graph based deep semi-supervised framework for classifying COVID-19 from chest X-rays.
Our framework introduces an optimisation model for graph diffusion that reinforces the natural relation among the tiny labelled set and the vast unlabelled data. We then connect the diffusion prediction output as pseudo-labels that are used in an iterative
scheme in a deep net. We demonstrate, through our experiments, that our model is able to outperform the current leading supervised model with a tiny fraction of the labelled examples. Finally, we provide attention maps to accommodate the radiologist's mental
model, better fitting their perceptual and cognitive abilities. These visualisation aims to assist the radiologist in judging whether the diagnostic is correct or not, and in consequence to accelerate the decision. |
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Awasthi, A, Sharma, et al |
Environment, Development and Sustainability |
Epidemiology| Épidémiologie |
In this study, the COVID-19 connection with various weather parameters like temperature, wind speed, and relative humidity
is investigated and the future scenario of COVID-19 is predicted based on the Gaussian model (GM). This study is conducted in Delhi, the capital city of India, during the lowest mobility rate due to strict lockdown nationwide for about two months from March
15 to May 17, 2020. Based on statistical analysis, this has been observed that the temperature parameter shows a significant positive trend during the period of study. The number of confirmed cases of COVID-19 is fitted with respect to the number of days by
using the Gaussian curve and it is estimated on the basis of the model that maximum cases will go up to 123,886 in number. The maximum number of cases will be observed during the range of 166 ± 36 days. Additionally, the linear regression technique is used
to find the trend of COVID-19 cases with temperature and it is estimated that with an increase in temperature by 1 °C, 30 new COVID-19 cases on daily basis will be expected to observe. |
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Barbu, MG, Thompson, et al |
Frontiers in Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to assess the impact of SARS-CoV-2 on the most prevalent comorbidities, among people who died of COVID-19
in Romania. The study sample consisted of 61.4% males and 38.6% females (n=814); the mean age was 68.2 y; 90.9% of deaths occurred in people 50+ years. The mean number of pre-existing conditions was 2.73 (SD = 1.521), with 97.4% of the patients having at least
one. The most prevalent comorbidities were hypertension (43.1%), diabetes (33.2%), and coronary heart disease (26.0%). The calculated relative risk of death due to COVID-19 was divided into 3 risk categories: high impact comorbidities (RR > 3) included diabetes
RR = 6.426 (95% CI, 4.965–8.318), chronic renal disease RR = 4.338 (95% CI, 3.556–5.292) and hypertension RR=3.261 (95% CI, 2.687–3.958). The medium impact (RR = 2–3) group comprised chronic pulmonary disease RR = 2.615 (95% CI, 2.061–3.319) and chronic liver
disease RR = 1.577 (95% CI, 1.183–2.104) and the low impact group (RR<2) –coronary heart disease RR = 0.664 (95% CI, 0.581–0.758), cancer RR = 0.515 (95% CI, 0.416–0.637) and stroke RR = 0.468 (95% CI, 0.370–0.593). |
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Bell, S, Campbell, et al |
BMC Nephrol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aims of this study are to report characteristics, rates and outcomes of all patients affected by infection with
SARS-CoV-2 undergoing kidney replacement therapy (KRT) in Scotland. Study design was an observational cohort study. During the period 1st March 2020 to 31st May 2020, 110 patients receiving KRT tested positive for SARS-CoV-2 amounting to 2% of the prevalent
KRT population. Of those affected, 86 were receiving haemodialysis or peritoneal dialysis and 24 had a renal transplant. Patients who tested positive were older and more likely to reside in more deprived postcodes. Mortality was high at 26.7% in the dialysis
patients and 29.2% in the transplant patients. |
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Early rehabilitation in a critically ill inpatient with coronavirus disease 2019: a case report |
Beom, J, Jung, et al |
Eur J Phys Rehabil Med |
Clinical data| Données cliniques |
A 58-year-old woman, previously without gait difficulty, was diagnosed with COVID-19 requiring endotracheal intubation
and mechanical ventilation. She also developed stress-induced cardiomyopathy. After management in intensive care unit for 15 days, she could not sit on a bed without back support. After receiving short-term inpatient rehabilitation therapy, lower limb muscle
strength, balance function, and gait speed had rapidly and significantly improved at the time of hospital discharge and at 1-month follow-up. |
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Practical Considerations for the Management of Cushing's Disease and COVID-19: A Case Report |
Beretta, F, Dassie, et al |
Frontiers in Endocrinology |
Clinical data| Données cliniques |
We report on COVID-19 pneumonia in the context of a complex case of Cushing's disease (CD). A 67-year-old man with
CD, who was admitted to our hospital, presented with signs and symptoms of adrenal insufficiency with persistent hypotension and glycemia toward the lower limits. We progressively withdrew almost all treatments for diabetes and CD (pasireotide and metyrapone),
and i.v. hydrocortisone was necessary. |
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Berger Gillam, Tara, Cole, et al |
medRxiv |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study aimed to pilot mass COVID-19 testing on a university research park, to assess the feasibility and acceptability
of scaling up testing to all staff and students. All staff and students (5,625) were eligible to participate. All participants were offered 4 PCR swabs, which they self-administered over two weeks. 798 (76%) of 1053 who registered provided at least one swab.
687 (86%) provided all four. 792 (99%) of 798 who submitted at least one swab had all negative results. 6 participants had one inconclusive result. There were no positive results. 458 (57%) of 798 participants responded to a post-testing survey, demonstrating
a mean acceptability score of 4.51/5, with 5 being the most positive. Repeated self-testing for COVID-19 using PCR is feasible and acceptable to a university population. |
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Bhargava, A, Sharma, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We assessed risk factors for death from COVID-19 among black inpatients at an urban center in Detroit, MI. This was
a retrospective, single-center cohort study. The case fatality rate was 29.1% (122/419). The mean duration of symptoms prior to hospitalization was 5.3 (3.9) days. Patients who died were older (mean SD] age, 68.7 14.8] years vs 60.3 16.0] years; p <0.0001),
had dementia (35 28.7%] vs 34 11.4%]; p <0.0001), hemiplegia (14 11.5%] vs 12 4.0%]; p=0.004), malignancy (11 9.0%] vs 12 4.0%]; p=0.04), and moderate-severe liver disease (4 3.3%] vs 1 0.3%]; p=0.01). The incidence of AMS on presentation was higher among
patients who died than those who survived, 43% vs. 20.0%, respectively (p<0.0001). From multivariable analysis, the odds of death increased with age (≥60 yrs.), admission from a nursing facility, Charlson score, altered mental status, higher C-reactive protein
on admission, need for mechanical ventilation, presence of shock, and acute respiratory distress syndrome. |
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Bhattacharyya, PJ, Attri, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
This is the first reported case of Takotsubo cardiomyopathy (TTC) in pregnancy as a manifestation of SARS-CoV-2 infection
during this ongoing pandemic. |
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Blagojevic, NR, Bosnjakovic, et al |
Int J Infect Dis |
Clinical data| Données cliniques |
We present a case of a 51-year-old patient with acute pericarditis as the dominant manifestation of SARS-CoV-2 infection. |
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Changing Age Distribution of the COVID-19 Pandemic - United States, May-August 2020 |
Boehmer, TK, DeVies, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie |
CDC examined the changing age distribution of the COVID-19 pandemic in the United States during May-August by assessing
three indicators: COVID-19-like illness-related emergency department (ED) visits, positive reverse transcription-polymerase chain reaction (RT-PCR) test results for SARS-CoV-2, the virus that causes COVID-19, and confirmed COVID-19 cases. Nationwide, the median
age of COVID-19 cases declined from 46 years in May to 37 years in July and 38 in August. Similar patterns were seen for COVID-19-like illness-related ED visits and positive SARS-CoV-2 RT-PCR test results in all U.S. Census regions. During June-August, COVID-19
incidence was highest in persons aged 20-29 years, who accounted for >20% of all confirmed cases. The southern United States experienced regional outbreaks of COVID-19 in June. In these regions, increases in the percentage of positive SARS-CoV-2 test results
among adults aged 20-39 years preceded increases among adults aged ≥60 years by an average of 8.7 days (range = 4-15 days), suggesting that younger adults likely contributed to community transmission of COVID-19. |
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Trajectories of Hospitalization in COVID-19 Patients: An Observational Study in France |
Boëlle, PY, Delory, et al |
J Clin Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Here, we analyze the trajectories of 1321 patients admitted to hospitals in northern and eastern France. We found that
the time from onset to hospitalization decreased with age, from 7.3 days in the 20-65 year-olds to 4.5 in the >80 year-olds (p < 0.0001). Overall, the length of stay in the hospital was 15.9 days, and the death rate was 20%. One patient out of four was admitted
to the intensive care unit (ICU) for approximately one month. The characteristics of trajectories changed with age: fewer older patients were admitted to the ICU and the death rate was larger in the elderly. Admission shortly after onset was associated with
increased mortality (odds-ratio (OR) = 1.8, Confidence Interval (CI) 95% 1.3, 2.6]) as well as male sex (OR = 2.1, CI 95% 1.5, 2.9]). Time from admission within the hospital to the transfer to ICU was short. The age- and sex-adjusted mortality rate decreased
over the course of the epidemic, suggesting improvement in care over time. |
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Borges da Silva Teles, G, Kaiser Uruhary Nunes Fonseca, et al |
J Thorac Imaging |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The purpose of the study was to evaluate the performance of CT in differentiating COVID-19 from other viral infections
using a standardized reporting classification. A total of 175 consecutive patients were retrospectively identified from a single tertiary-care medical center from March 15-24, 2020. Patients with COVID-19 were older than patients with other viral infections
(P=0.038). The inter-rater agreement of CT categories between the readers ranged from good to excellent, κ=0.80 (0.73 to 0.87). Final CT categories were statistically different among COVID-19 and non-COVID-19 groups (P<0.001). CT "typical" appearance was more
prevalent in the COVID-19 group (64/87, 73.6%) than in the non-COVID-19 group (2/88, 2.3%). When considering CT "typical" appearance as a positive test, a sensitivity of 73.6% (95% confidence interval CI]: 63%-82.4%), specificity of 97.7% (95% CI: 92%-99.7%),
positive predictive value of 97% (95% CI: 89.5%-99.6%), and negative predictive value of 78.9% (95% CI: 70%-86.1%) were observed. |
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Braga, JU, Ramos, et al |
BMC Public Health |
Epidemiology| Épidémiologie |
This study aims to classify neighborhoods in the city of Fortaleza according to their propensity for a severe epidemic
of COVID-19 in 2020. We conducted an ecological study within the geographical area of the 119 neighborhoods located in the city of Fortaleza. The neighborhoods with the highest propensity for a severe COVID-19 epidemic were Aldeota, Cais do Porto, Centro,
Edson Queiroz, Vicente Pinzon, Jose de Alencar, Presidente Kennedy, Papicu, Vila Velha, Antonio Bezerra, and Cambeba. Importantly, we found that the propensity for a COVID-19 epidemic was high in areas with differing socioeconomic profiles. These areas include
a very poor neighborhood situated on the western border of the city (Vila Velha), neighborhoods characterized by a large number of subnormal agglomerates in the Cais do Porto region (Vicente Pinzon), and those located in the oldest central area of the city,
where despite the wealth, low-income groups have remained (Aldeota and the adjacent Edson Queiroz). |
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Braithwaite, J, Tran, et al |
Int J Qual Health Care |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
The study aimed to investigate relationships between governments' capacity to respond (CTR), their response stringency,
scope of COVID-19 testing, and COVID-19 outcomes. The multidimensional scaling (MDS) model found three dimensions explaining 91% of the variance and cluster analysis identified five national groupings. There was no association between national governments'
pre-pandemic CTR and the adoption of early stringent public health measures or approach to COVID-19 testing. Two national clusters applied early stringency measures and reported significantly lower cumulative deaths. The best performing national cluster (comprising
Australia, South Korea, Iceland and Taiwan) adopted relatively early stringency measures but broader testing earlier than others which was associated with a change in disease trajectory and the lowest COVID-19 death rates. Two clusters (one with high CTR and
one low) both adopted late stringency measures and narrow testing and performed least well in COVID-19 outcomes. |
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Branquinho, C, Kelly, et al |
J Community Psychol |
Public Health response| Interventions de santé publique |
The study objectives were: (1) To give adolescents and youth a voice and listen to the impact of coronavirus disease
2019 (COVID-19) in their lives; (2) to identify their coping strategies; (3) present lessons learned to be better prepared for future pandemics. 617 participants from 16 to 24 years old (M = 19.2 years; F = 19.1 years) answered the online questionnaire during
the pandemic lockdown. In terms of impacts, stands out: biological-headaches and muscle pain; psychological-more time to perform pleasant and personal development activities, but more symptoms of depression, anxiety, and loneliness, longer screen time, and
more substance use; social-increase of family conflicts and disagreements, loss of important life moments, contacts, and social skills, but it allows a greater selection of friendships. Regarding coping strategies, the importance of facing these times with
a positive perspective, carrying out pleasurable activities, keeping in touch with family and friends, and establishing routines are emphasized. |
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COVID-19 Severity and Outcomes in Patients With Cancer: A Matched Cohort Study |
Brar, G, Pinheiro, et al |
J Clin Oncol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objectives of this study were to determine if patients with cancer have worse outcomes compared with patients without
cancer and to identify demographic and clinical predictors of morbidity and mortality among patients with cancer. We included 585 patients who were COVID-19 positive, of whom 117 had active malignancy, defined as those receiving cancer-directed therapy or
under active surveillance within 6 months of admission. Presenting symptoms and in-hospital complications were similar between the cancer and noncancer groups. Nearly one half of patients with cancer were receiving therapy, and 45% of patients received cytotoxic
or immunosuppressive treatment within 90 days of admission. There were no statistically significant differences in morbidity or mortality (P = .894) between patients with and without cancer. |
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Brendish, NJ, Poole, et al |
J Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We compared clinical characteristics, symptoms, and outcomes of adults presenting to hospital during the pandemic first
wave, who tested positive and negative for SARS-CoV-2. 1054 patients were included: 352 (33.4%) tested positive and 702 (66.6%) negative. 13.4% (47/352) COVID-19-positive patients had COPD versus 18.7% (131/702) of COVID-19-negative patients (difference=5.3%
95%CI -9.7% to -0.5%], p=0.0297). 5.7% (20/352) of COVID-19-positive patients were smokers versus 16.5% (116/702) of negative patients (difference=-10.8% -14.4% to -7.0%], p=0.0001). 70.5% (248/352) of COVID-19-positive patients were White-British versus 85.5%
(600/702) of negative patients (difference=-15.0% -20.5% to -9.7%], p<0.0001). 20.9% (39/187) of COVID-19-positive patients were healthcare workers versus 5.2% (15/287) of negative patients (p<0.0001). Anosmia was reported in 33.1% (47/142) versus 8.8% (19/216)
of COVID-19-positive and negative patients respectively (p<0.0001). Non-SARS-CoV-2 respiratory viruses or atypical bacteria were detected in 2.5% (5/197) of COVID-19 patients versus 7.9% (24/302) of COVID-19-negative patients (p=0.0109). Hospitalisation duration
and 30-day-mortality were higher in COVID-19 patients and invasive ventilation was more frequent (11.1% vs 2.8%, p<0.0001), and longer (14.5 vs 4.7 days, p=0.0015). |
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32970540; The Effects of Covid-19 Pandemic on Syrian Refugees in Turkey: The Case of Kilis |
Budak, F, Bostan, et al |
Social Work in Public Health |
Public Health response| Interventions de santé publique |
The objective of this study; is to find out the sensitivity, the concern that are created by the Covid-19 pandemic
on the Syrian refugees, who live in Kilis province of Turkey and have different life standards and status and to find out their possibilities and attitudes of prevention from and combating the pandemic. The data of the study were collected between 12–16 April
2020 by applying a questionnaire on 414 refugees. According to the study results, it has been discovered that the refugees have concerns about Covid-19 and their insensitivity levels are low. It has been seen that there is a group who are not aware of the
seriousness of the pandemic, who do not have enough information about the pandemic and cannot reach personal protective equipment (such as masks, gloves). |
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Bullinger, Lindsey, Boy, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
The policy response to the COVID-19 pandemic led to a sudden and unprecedented increase in the amount of time parents
and children spent at home. We use real-time, novel mobile phone movement data and quick-release administrative data on child maltreatment referrals to examine how time at home is related to allegations of child maltreatment. Findings show that allegations
plummeted by approximately 55% following the emergency declaration relative to 2018 and 2019 trends during the same time period. However, time at home during the pandemic was associated with more referrals, particularly of supervisory neglect, with the largest
impacts in metropolitan counties, counties with historically lower referral rates, and counties with more poverty. We also find that more time at home is positively related to educational neglect referrals among children in areas with high poverty and higher
referral rates. Our results highlight how children and families are faring during the pandemic, and we offer several clinical and policy implications. |
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Estimating the severity of COVID-19: Evidence from the Italian epicenter |
Buonanno, P, Galletta, et al |
PLoS One |
Epidemiology| Épidémiologie |
We provide results on the level of COVID-19 excess mortality in the Italian region of Lombardy and in the province
of Bergamo using official and original data sources. Since February 2020 Lombardy and in particular the province of Bergamo have been severely hit by the novel COVID-19 infectious disease. Combining official statistics, retrospective data and original data
(i.e., obituaries and death notices) we provide a tentative estimate of the number of deaths either directly or indirectly, associated with COVID-19 as well as the total number of persons infected. Our findings suggest that the reported number of deaths attributable
to COVID-19 identified by public authorities accounts only for one half of the observed excess mortality between March 2020 and previous years. |
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COVID-19 community assessment hubs in Ireland—the experience of clinicians |
Bury, G, Smith, et al |
Irish journal of medical science |
Healthcare Response | Réponse des soins de santé |
The aim of this article is to describe infection control procedure training in Ireland, the uptake by GPs and the initial
experience of GPs working in this unusual environment. Six hundred seventy-five participants (including 439 GPs, 156 GP registrars) took part in the training. Two hundred thirty-nine (50.3%) out of four hundred seventy-five responded to Survey 1—over 95% reported
an increase in confidence in the use of PPE. Two hundred ten (44.2%) out of four hundred seventy-five participants responded to Survey 2; 195 had completed hub shifts. Younger, female GPs predominated. Very high levels of infection control procedures were
reported. Participants commented positively on teamworking, environment and systems. However, ‘real-time’ ambulance service data suggest the peak of the surge may have passed by the time the hubs were established. |
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Butt, JH, Fosbøl, et al |
Circulation |
Healthcare Response | Réponse des soins de santé |
To shed light on the possible collateral effects of a lockdown strategy and reprioritization within the healthcare
system, we performed a nationwide cohort study to investigate stroke and transient ischemic attack (TIA) admission rates and prognosis in Denmark during the COVID-19 pandemic. The mortality rates among patients admitted with stroke/TIA, overall and according
to subtypes, before and after March 13 were not significantly different in 2020 compared with 2017 to 2019. |
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Cai, Y, Liu, et al |
Journal of International Medical Research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to investigate associations between the clinical characteristics and incubation periods of patients
infected with COVID-19 in Wuhan, China. Analysis of the distribution and receiver operator characteristic curve of incubation periods showed that 7 days was the optimal cut-off value to assess differences in disease severity between groups. Patients with shorter
(≤7 days) incubation periods (n = 79) had more severe disease, longer durations of hospitalization, longer times from symptom onset to discharge, more abnormal laboratory findings, and more severe radiological findings than patients with longer (>7 days) incubation
periods. Regression and correlation analyses also showed that a shorter incubation period was associated with longer times from symptom onset to discharge. |
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Campagnaro, R, Collet, et al |
Child Youth Serv Rev |
Public Health response| Interventions de santé publique |
This study aimed to assess the impact of the pandemic on fear, dietary choices and oral health perceptions of parents.
A questionnaire containing 19 questions was remotely applied to 1003 parents of children aged 0-12 years. 73% of respondents reported income loss. Five hundred sixty-eight people denied seeking medical or dental care. 61.5% of respondents revealed changes
in the dietary pattern; most of them mentioned an increase in food intake. Most parents (66.6%) would only seek urgent dental care. There was an association between parents' willingness to take their children to dental appointments with the fear level (p <
0.001). |
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Canevelli, M, Palmieri, et al |
Annali dell'Istituto Superiore di Sanita |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Authors aimed to compare COVID-19-specific and all-cause mortality rates among natives and migrants in Italy and to
investigate the clinical characteristics of individuals dying with COVID-19 by native/migrant status. The clinical phenotype of migrants dying with COVID-19 was similar to that of natives except for the younger age at death. |
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Carothers, C, Birrer, et al |
Pharmacotherapy |
Clinical data| Données cliniques |
Authors present two cases of suspected remdesivir-associated acute liver failure (ALF) in which the liver failure improved
following continuous infusion acetylcysteine and withdrawal of remdesivir. Due to its novel nature and only recent widespread use, there is very little data on the risk of ALF from remdesivir. |
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The role of transport accessibility within the spread of the Coronavirus pandemic in Italy |
Cartenì, A, Di Francesco, et al |
Safety Science |
Public health interventions*| Interventions de santé publique |
This paper aims to support policies and decision makers in defining the most appropriate strategies to manage the Covid-19
crisis. The quantitative estimates performed show that a possible and probably more sustainable policy for containing social interactions could be to apply lockdowns in proportion to the transport accessibility of the areas concerned, in the sense that the
higher the accessibility, the tighter should be the mobility restriction policies adopted. |
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Carter, B, Collins, et al |
J Hosp Infect |
Epidemiology| Épidémiologie Transmission |
To identify patients who acquire COVID-19 in hospital (nosocomial COVID-19 infection (NC)) and their risk of mortality
compared to those with community-acquired COVID-19 (CAC) infection. The minority of COVID-19 cases were the result of NC transmission. |
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The turning point and end of an expanding epidemic cannot be precisely forecast |
Castro, M, Ares, et al |
Proc Natl Acad Sci U S A |
Epidemiology| Épidémiologie |
Authors discuss the time at which the growth in the number of infected individuals halts and starts decreasing cannot
be calculated with certainty before the turning point is actually attained; neither can the end of the epidemic after the turning point. The study warns against precise forecasts of the evolution of epidemics based on mean-field, effective, or phenomenological
models and supports that only probabilities of different outcomes can be confidently given. |
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Lip necrosis in a patient with paroxysmal nocturnal hemoglobinuria: Can it be triggered by COVID-19? |
Cebeci Kahraman, F, Özen, et al |
J Cosmet Dermatol |
Clinical data| Données cliniques |
Authors report a case of hemorrhagic necrosis on the lip in a patient with paroxysmal nocturnal haemoglobinuria (PNH)
and COVID-19 infection and briefly discuss its possible mechanism. This current case presentation will contribute to the literature as another case with COVID-19 triggering mucosal involvement. |
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Ceulemans, M, Verbakel, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
Authors aimed to assess the susceptibility of pregnant women to SARS-CoV-2 and women’s perceived impact of the pandemic
on their breastfeeding practices, medical counseling and social support. Women without previous breastfeeding experience and in the early postpartum period experienced a higher burden in terms of reduced medical counseling and support. |
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Chakraborty, J |
Disability and Health Journal |
Epidemiology| Épidémiologie |
This article presents the first national scale study of the relationship between COVID-19 incidence and disability
characteristics in the U.S. Socio-demographically disadvantaged people with disabilities (PwDs) are significantly overrepresented in counties with higher COVID-19 incidence compared to other PwDs. |
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The geography of social distancing in Canada: Evidence from facebook |
Chan, J |
Canadian Public Policy |
Public Health response| Interventions de santé publique |
This article analyzes which characteristics are correlated with mobility reductions during the COVID-19 pandemic, using
census-division-level mobility data for Canada from Facebook. There is significant variation in the extent to which social distancing was applied in April, relative to a preperiod of February. I find that the population and population density of a census division
are strongly correlated with larger mobility reductions. Conversely, I find that areas with a larger share of dwellings that are apartments exhibit smaller mobility reductions, suggesting that those in tighter living conditions may find it less possible to
stay at home during the pandemic. Finally, I examine the persistence of mobility reductions into May and show that areas with a larger apartment dwelling share are more likely to maintain their social distancing over time. © Canadian Public Policy / Analyse
de politiques, July / juillet 2020 |
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Exercise Behavior and Mood during the COVID-19 Pandemic in Taiwan: Lessons for the Future |
Chang, YK, Hung, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
This study aims to explore the influence of COVID-19 on exercise behavior and its impact on mood states, as well as
predict changes in exercise behavior during a similar future pandemic in Taiwan. Frequent exercisers are more likely to maintain their exercise frequency during a similar pandemic. |
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Che Azemin, MZ, Hassan, et al |
International Journal of Biomedical Imaging |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We aimed to use thousands of readily available chest radiograph images with clinical findings associated with COVID-19
as a training data set, mutually exclusive from the images with confirmed COVID-19 cases, which will be used as the testing data set. We used a deep learning model based on the ResNet-101 convolutional neural network architecture, which was pretrained to recognize
objects from a million of images and then retrained to detect abnormality in chest X-ray images. The performance of the model in terms of area under the receiver operating curve, sensitivity, specificity, and accuracy was 0.82, 77.3%, 71.8%, and 71.9%, respectively.
The strength of this study lies in the use of labels that have a strong clinical association with COVID-19 cases and the use of mutually exclusive publicly available data for training, validation, and testing. |
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Chen, S, Liu, et al |
Ups J Med Sci |
Clinical data| Données cliniques |
Authors aimed to analyse the relationship between coagulation dysfunction and liver damage in patients with COVID-19.
Coagulation dysfunction in patients with COVID-19 is closely related to liver damage. |
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Cheng, MH, Zhang, et al |
Proc Natl Acad Sci U S A |
Clinical data| Données cliniques |
Using structure-based computational models, we demonstrate that the SARS-CoV-2 spike (S) glycoprotein exhibits a high-affinity
motif for binding TCRs, and may form a ternary complex with Multisystem Inflammatory Syndrome in Children (MIS-C). Data suggest that SARS-CoV-2 S may act as a superantigen to trigger the development of MIS-C as well as cytokine storm in adult COVID-19 patients,
with important implications for the development of therapeutic approaches. |
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Chi, H, Vu, et al |
Data Brief |
Public Health response| Interventions de santé publique |
This paper presents the dataset of a survey on workplace health and safety training, employees' risk perceptions, behavioral
safety compliance, and perceived job insecurity in Vietnam during COVID-19 pandemic. The data were collected through an online questionnaire completed by Vietnamese full-time employees between April and June 2020. Using E-mail, LinkedIn, and Facebook, the
online questionnaire was sent to respondents who filled it out voluntarily. A two-wave survey was conducted in order to lessen the common method bias. Totally, we received complete matched data for 732 full-time employees. All data were processed through SPSS
22.0, AMOS 23.0 and Smart PLS 3.0. Besides descriptive statistics, the results of the explanatory factor analysis and the confirmation factor analysis were included in this paper, which may serve as a good reference for future studies. |
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An initiative to evaluate the safety of maternal bonding in patients with SARS-CoV-2 infection |
Cojocaru, L, Crimmins, et al |
J Matern Fetal Neonatal Med |
Transmission Clinical data| Données cliniques |
This is a quality improvement project that analyzed all cases of SARS-CoV-2 positive pregnancies that delivered at
a major health care system from 3 January 2020 to 6 January 2020. Our results have illustrated that maternal bonding appears safe in neonates born to mothers that are SARS-CoV-2 positive. |
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Coll-Rubio, P |
Tripodos |
Public Health response| Interventions de santé publique |
This article presents the results of a study carried out using data provided by professionals responsible for planning
and executing communication strategies for 30 leading companies involved in the digital economy of Barcelona, site of the Mobile World Congress technological trade show, which was cancelled in 2020 due to the COVID-19 health crisis. The results of the study,
carried out electronically from 1-15 April 2020, show that 77% of the technology companies that participated in the study changed their strategic communication planning during the first month of the state of alarm declared by the Spanish government on 14 March
2020. |
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Epilepsy and lockdown: A survey of patients normally attending a Spanish center |
Conde Blanco, E, Manzanares, et al |
Acta Neurol Scand |
Public Health response| Interventions de santé publique |
Authors sent an online 22-item questionnaire to patients from our outpatient clinic, a reference center in Spain for
drug-resistant epilepsy, inquiring about the effects of lockdown, from March to May 2020. Seizure frequency and severity remained unchanged in most patients during the lockdown. |
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Unilateral Hypoglossal Nerve Palsy as a Covid-19 sequel: a case report |
Costa Martins, D, Branco Ribeiro, et al |
Am J Phys Med Rehabil |
Clinical data| Données cliniques |
Authors describe the case of a newly diagnosed unilateral hypoglossal nerve palsy (HNP) in a severe Covid-19 patient.
Even though a reasonable doubt remains, it cannot be excluded that it may be a neurological manifestation of SARS-CoV-2, the authors believe it to be the cause of the palsy. |
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Darabi, Atefe, Siami, et al |
ArXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
This study aims to highlight the effect of time-delay in the progress of such infectious diseases in the meta-population
networks rather than individuals or a single population. The numerical results, along with the theoretical expectations, highlight the impact of time-delay as well as the importance of considering the worst-case scenarios in investigating the most effective
methods of epidemic containment. |
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Developing an Understanding of Adolescents' Knowledge, Attitudes, and Practices Toward COVID-19 |
Dardas, LA, Khalaf, et al |
J Sch Nurs |
Public Health response| Interventions de santé publique |
The purpose of this study was to explore the knowledge, attitudes, and practices toward COVID-19 and their correlates
among Jordanian adolescents. Tailored efforts are needed to improve the levels of knowledge, attitudes, and practices among adolescents. |
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Heparin Induced Thrombocytopenia in Severe COVID-19 Patients |
Daviet, F, Guervilly, et al |
Circulation |
Clinical data| Données cliniques |
Authors retrospectively reviewed all cases of HIT among patients presenting with COVID-19 acute respiratory distress
syndrome in two intensive care units in southern |
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de Havenon, A, Yaghi, et al |
J Neurointerv Surg |
Clinical data| Données cliniques |
Authors aimed to compare the outcome of acute ischemic stroke (AIS) patients who received endovascular thrombectomy
(EVT) with confirmed COVID-19 to those without. In AIS patients treated with EVT, comorbid COVID-19 infection was associated with in-hospital death and a lower odds of favorable discharge compared with patients without COVID-19, but not compared with AIS patients
with COVID-19 who did not undergo EVT. |
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Acute disseminated encephalomyelitis in a COVID-19 pediatric patient |
de Miranda Henriques-Souza, AM, de Melo, et al |
Neuroradiology |
Clinical data| Données cliniques |
The authors present a case of acute disseminated encephalomyelitis in a COVID-19 pediatric patient with positive SARS-CoV2
markers from a nasopharyngeal swab. She evolved with partial clinical and neurological improvement and was subsequently discharged. |
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De Vita, S, Ippolito, et al |
Echocardiography |
Clinical data| Données cliniques |
We report the case of a healthy 35-year-old woman who had experienced a flu-like syndrome during the week before childbirth
and heart failure symptoms 10 days before the current hospitalization and presented to our emergency department with clinical signs of congestive heart failure, echocardiographic evidence of a severely dilated and hypokinetic heart, laboratory evidence of
SARS-CoV-2 disease, and radiologic findings consistent with both virus-related pneumonia and heart failure. Early cardiac magnetic resonance was crucial for the diagnosis of postpartum cardiomyopathy and for the exclusion of virus-related myocarditis, allowing
us to decide on a prudent and supportive clinical approach. |
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Debowska, A, Horeczy, et al |
Psychol Med |
Public Health response| Interventions de santé publique |
In this letter to the editor authors assessed stress, depression, anxiety, and suicidality among medical, psychology,
and other students. Findings demonstrate a significant increase in depression as the pandemic was progressing. |
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Del Brutto, OH, Costa, et al |
Pathog Glob Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Authors assessed the incidence of SARS-CoV-2 infection in a rural population. One month after baseline testing, 362
of 370 initially seronegative individuals were re-tested to assess incidence of seroconversion and associated risk factors. Twenty-eight of them (7.7%) became seropositive. The overall incidence rate ratio was 7.4 per 100 person months of potential virus exposure
(95% C.I.: 4.7-10.2). Six seroconverted individuals (21.4%) developed SARS-CoV-2-related symptomatology. The only covariate significantly associated with seroconversion was the use of an open latrine. Predictive margins showed that these individuals were 2.5
times more likely to be infected (95% C.I.: 1.03-6.1) than those using a flushing toilet. Increased seroconversion in individuals using latrines is consistent with a contributory role of fecal-oral transmission, although we cannot rule out the possibility
that latrines are acting as a proxy for poverty or other unknown interacting variables. |
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A Novel Pediatric Multisystem Inflammatory Syndrome During the COVID-19 Pandemic |
Del Greco, G, Brady, et al |
Pediatr Emerg Care |
Clinical data| Données cliniques |
Authors present 4 patients along with their emergency department course, so providers will have a better understanding
of the identification and workup of these patients. All patients required admission, but 2 required the pediatric intensive care unit for cardiac and/or respiratory support or closer monitoring. |
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The impact of COVID-19 and lockdown on plastic surgery training and practice in India |
Dharini, Kumar, S, et al |
Indian Journal of Plastic Surgery |
Healthcare Response | Réponse des soins de santé |
Authors discuss how lockdown, physical distancing, and restrictions on medical practice have affected the training
of residents and the professional and personal life of plastic surgeons. Universities need to recognize the loss in training for residents due to the pandemic and formulate plans to overcome it. |
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Di Corrado, D, Magnano, et al |
Sport Sciences for Health |
Public Health response| Interventions de santé publique |
The aim of this study was to survey the general community in Italy to better recognize their levels of psychological
impact, emotional responses and maintaining their daily exercise or physical activity routines during the initial stage of the COVID-19 outbreak. Methods: 670 adults were invited to complete an online survey collecting information on demographic data, physical
and emotional symptoms in the past 14 days, contact history with COVID-19, and keeping regular physical activity. Data analysis was conducted through mixed qualitative and quantitative methods. Results: During the initial phase of the COVID-19 outbreak in
Italy, more than half of the respondents reported a significant psychological and physical impact. |
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Di Crosta, A, Palumbo, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
The aim of the present study is to report the prevalence of high psychological distress due to the COVID-19 pandemic
on the general population, especially considering that this aspect is consistently associated with PTSD symptoms. Furthermore, the present study aims to identify the risk factors for high PTSD symptoms, including individual differences and subjective perception
of both economic and psychological aspects. We administered an online survey to 1253 participants during the peak period of the contagion in Italy. A logistic regression on the Impact of Event Scale – Revised (IES-R) scores was used to test the risk factors
that predict the possibility to develop PTSD symptoms due to the COVID-19 pandemic. Gender (female), lower perceived economic stability, higher neuroticism, and fear and consequences of contagion were predictors of high PTSD symptomatology. The results extend
our understanding of the COVID-19 pandemic’s impact on the population’s mental health, by identifying individuals at high-risk of developing PTSD. |
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Díaz-Sánchez, JP, Obaco, et al |
Journal of Policy Research in Tourism, Leisure and Events |
Economics | Économie |
OBJECTIVE: Obesity is a major risk factor for becoming seriously ill with the 2019 novel coronavirus (COVID-19). One
difficulty faced by clinicians and by patients is the unknown time frame of hospitalization until discharge of symptomatic patients. METHODS: We followed 34 patients with laboratory-confirmed COVID-19 infection who recovered fromthe infection. All diagnoses
were given using semi-quantitative RT-PCR on nasopharyngeal swabs. Envelope protein gene (E), RNA-dependent RNA polymerase gene (RdRP), and nucleocapsid gene (N) were measured by RT-PCR. Weight was measured and height was self-reported. RESULTS: Mean ± SD
age was 51.8 ± 16.7 years. Mean ± SD body mass index (BMI) was 27.4 ± 4.7 kg/m2. 26% (9/34) had obesity, with BMI above 30 kg/m2. Fifteen patients had BMI between 25 and 29.9 kg/m2. The mean length of hospital stay was longer for those with a BMI >25 kg/m2
(n = 24) than for those with a normal BMI (19.2 vs. 16.0 days, p = 0.08). Comparing people with obesity (BMI >30 kg/m2 or above) to those without obesity, the difference was larger (20.6 vs. 16.0 days, p = 0.06). A trend for correlation between body weight
and the time to negative detection of RdRp gene was found (r = 0.33, p = 0.09). CONCLUSIONS: Our results highlight the need for priority of early detection and testing, and early therapy for people with obesity and COVID-19 infections. |
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A Time Frame for Testing Negative for SARS-COV2 in People with Obesity |
Dicker, D, Lev, et al |
Obes Facts |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Understanding how potent neutralizing antibodies (NAbs) inhibit SARS-CoV-2 is critical for effective therapeutic development.
We previously described BD-368-2, a SARS-CoV-2 NAb with high potency; however, its neutralization mechanism is largely unknown. Here, we report the 3.5-Å cryo-EM structure of BD-368-2/trimeric-spike complex, revealing that BD-368-2 fully blocks ACE2 recognition
by occupying all three receptor-binding domains (RBDs) simultaneously, regardless of their “up” or “down” conformations. Also, BD-368-2 treats infected adult hamsters at low dosages and at various administering windows, in contrast to placebo hamsters that
manifested severe interstitial pneumonia. Moreover, BD-368-2’s epitope completely avoids the common binding site of VH3-53/VH3-66 recurrent NAbs, evidenced by tripartite co-crystal structures with RBDs. Pairing BD-368-2 with a potent recurrent NAb neutralizes
SARS-CoV-2 pseudovirus at pM level and rescues mutation-induced neutralization escapes. Together, our results rationalized a new RBD epitope that leads to high neutralization potency and demonstrated BD-368-2’s therapeutic potential in treating COVID-19. ©
2020 Elsevier Inc. Du et al. showed how a potent COVID-19 antibody, BD-368-2, interacts with the SARS-CoV-2 spike trimer to neutralize the virus and effectively treat severely infected hamsters. They further demonstrated how BD-368-2 can be paired with additional
antibodies to form a cocktail that prevents the evolution of viral escape mutants. © 2020 Elsevier Inc. |
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Du, S, Cao, et al |
Cell |
Therapeutics| Thérapeutique Animal model | Modèle animal |
Here, we report the 3.5-Å cryo-EM structure of BD-368-2/trimeric-spike complex, revealing that BD-368-2 fully blocks
ACE2 recognition by occupying all three receptor-binding domains (RBDs) simultaneously, regardless of their “up” or “down” conformations. Also, BD-368-2 treats infected adult hamsters at low dosages and at various administering windows, in contrast to placebo
hamsters that manifested severe interstitial pneumonia. Moreover, BD-368-2’s epitope completely avoids the common binding site of VH3-53/VH3-66 recurrent NAbs, evidenced by tripartite co-crystal structures with RBDs. Pairing BD-368-2 with a potent recurrent
NAb neutralizes SARS-CoV-2 pseudovirus at pM level and rescues mutation-induced neutralization escapes. Together, our results rationalized a new RBD epitope that leads to high neutralization potency and demonstrated BD-368-2’s therapeutic potential in treating
COVID-19. |
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Managing the COVID-19 pandemic in poor urban neighborhoods: The case of Accra and Johannesburg |
Durizzo, K, Asiedu, et al |
World Development |
Public Health response| Interventions de santé publique |
In order to understand how the urban poor mitigate their risk of infection, we conducted a survey with more than 1,400
poor households in two of the African cities with the most COVID-19 infections, Accra and Greater Johannesburg, early in the pandemic, during lockdowns of public life. We find that many of the urban poor already engage in the appropriate hygienic behavior
and follow social distancing rules. However, despite citywide lockdowns, about 25–40% of people still report attending large gatherings, 10–20% report receiving guests at home, and 30–35% report leaving the house more than once per week. Lack of cooperation
with governmental regulations seems to be more related to a lack of infrastructure or poverty rather than unwillingness to engage in behavioral change. Interestingly, even with the stricter lockdown in South Africa, people are at least equally likely to deviate
from social distancing rules. About half of the sample in both countries report knowing (mainly through TV) about current COVID-19 case numbers. Most participants know that coughing is a symptom, but only half mention fever and difficulty breathing, and very
few people mention tiredness. Ghanaians seem to be somewhat better informed. |
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CSF biomarkers in patients with COVID-19 and neurological symptoms: A case series |
Edén, A, Kanberg, et al |
Neurology |
Clinical data| Données cliniques |
OBJECTIVE: To explore whether hospitalized patients with SARS-CoV-2 and neurologic symptoms have evidence of CNS infection,
inflammation and injury using CSF biomarker measurements. METHODS: We assessed CSF SARS-CoV-2 RNA along with CSF biomarkers of intrathecal inflammation (CSF white blood cell count, neopterin, β(2)-microglobulin (β(2)M) and immunoglobulin G-index), blood-brain-barrier
(BBB) integrity (albumin ratio), and axonal injury (CSF neurofilament light chain protein NfL]) in 6 patients with moderate to severe COVID-19 and neurologic symptoms who had undergone a diagnostic lumbar puncture. Neurologic symptoms and signs included features
of encephalopathies (4/6), suspected meningitis (1/6) and dysgeusia (1/6). SARS-CoV-2 infection was confirmed by rtPCR analysis of nasopharyngeal swabs. RESULTS: SARS-CoV-2 RNA was detected in the plasma of 2 patients (Cycle threshold Ct] value 35.0-37.0)
and in CSF at low levels (Ct 37.2, 38.0, 39.0) in 3 patients in one but not in a second rtPCR assay. CSF neopterin (median, 43.0 nmol/L) and β(2)-microglobulin (median, 3.1 mg/L) were increased in all. Median IgG-index (0.39), albumin ratio (5.35) and CSF
white blood cell count (<3 cells/µL) were normal in all, while CSF NfL was elevated in 2 patients. CONCLUSION: Our results on patients with COVID-19 and neurologic symptoms suggest an unusual pattern of marked CSF inflammation in which soluble markers were
increased but white cell response and other immunologic features typical of CNS viral infections were absent. While our initial hypothesis centered on CNS SARS-CoV-2 invasion, we could not convincingly detect SARS-CoV-2 as the underlying driver of CNS inflammation.
These features distinguish COVID-19 CSF from other viral CNS infections, and raise fundamental questions about the CNS pathobiology of SARS-CoV-2 infection. |
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Eltoukhy, AEE, Shaban, et al |
Int J Environ Res Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The number of COVID-19 cases can be accurately predicted by considering historical data of reported cases alongside
some external factors that affect the spread of the virus. In the literature, most of the existing prediction methods focus only on the historical data and overlook most of the external factors. Hence, the number of COVID-19 cases is inaccurately predicted.
Therefore, the main objective of this study is to simultaneously consider historical data and the external factors. This can be accomplished by adopting data analytics, which include developing a nonlinear autoregressive exogenous input (NARX) neural network-based
algorithm. The viability and superiority of the developed algorithm are demonstrated by conducting experiments using data collected for top five affected countries in each continent. The results show an improved accuracy when compared with existing methods.
Moreover, the experiments are extended to make future prediction for the number of patients afflicted with COVID-19 during the period from August 2020 until September 2020. |
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Brain ischemic injury in CoViD19 infected patients: a series of 10 post-mortem cases |
Fabbri, VP, Foschini, et al |
Brain Pathol |
Clinical data| Données cliniques |
The coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
COVID-19 symptoms are not limited to the respiratory tract, but complications have been described involving other organs including brain. At present, data on SARS-CoV-2 neuropathological features are limited 4, 5, 8, 10] and most frequently focused on cases
presenting neurological symptoms. |
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Serological cross-reactivity using a SARS-CoV-2 ELISA test in acute Zika virus infection, Colombia |
Faccini-Martínez Á, A, Rivero, et al |
Int J Infect Dis |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We investigated seroreactivity, using a commercial SARS-CoV-2 ELISA test, in samples collected from different individuals'
groups, including patients diagnosed as Dengue, Zika, and Chikungunya infection during 2015 and 2019, from an endemic area at the Caribbean Colombian region. We found 26% of serological cross-reactivity in patients with acute Zika virus infection using a commercial
SARS-CoV-2 ELISA test. Further studies could evaluate if serological cross-reaction is maintaining along the time in a non-acute patient with previous exposure to the Zika virus and its effect in SARS-CoV-2 serosurveys in endemic areas for this arbovirus. |
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Light and corona: guided-wave readout for coronavirus spike protein-host-receptor binding |
Fedotov, IV, Yi, et al |
Opt Lett |
Coronavirology| Coronavirologie |
We show that waveguide sensors can enable a quantitative characterization of coronavirus spike glycoprotein-host-receptor
binding-the process whereby coronaviruses enter human cells, causing disease. We demonstrate that such sensors can help quantify and eventually understand kinetic and thermodynamic properties of viruses that control their affinity to targeted cells, which
is known to significantly vary in the course of virus evolution, e.g., from SARS-CoV to SARS-CoV-2, making the development of virus-specific drugs and vaccine difficult. With the binding rate constants and thermodynamic parameters as suggested by the latest
SARS-CoV-2 research, optical sensors of SARS-CoV-2 spike protein-receptor binding may be within sight. |
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Fintelman-Rodrigues, N, Sacramento, et al |
Antimicrobial Agents and Chemotherapy |
Therapeutics| Thérapeutique |
Extensive use of atazanavir (ATV) as antiretroviral and previous evidence suggesting its bioavailability within the
respiratory tract prompted us to study this molecule against SARS-CoV-2. Our results show that ATV docks in the active site of SARS-CoV-2 Mpro with greater strength than LPV, blocking Mpro activity. We confirmed that ATV inhibits SARS-CoV-2 replication, alone
or in combination with ritonavir (RTV) in Vero cells and a human pulmonary epithelial cell line. ATV/RTV also impaired virus-induced enhancement of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-a) levels. Together, our data strongly suggest that
ATV and ATV/RTV should be considered among the candidate repurposed drugs undergoing clinical trials in the fight against COVID-19 |
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Fisler, G, Haimed, et al |
Chest |
Clinical data| Données cliniques |
Infection with the severe acute respiratory syndrome coronavirus 2 causes severe acute lung injury in approximately
5% of infected adults, but few reports have been made of severe pediatric disease. We present an adolescent patient who contracted severe acute respiratory syndrome coronavirus 2 one week after a paternal haplo-identical hematopoietic stem cell transplant,
with development of severe hyperferritinemic acute lung injury and macrophage activation-like syndrome. We present her case and a comparison of her laboratory data with those of a cohort of pediatric patients with coronavirus disease 2019 without severe disease.
© 2020 American College of Chest Physicians |
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Fitriani, R, Gede Nyoman Mindra Jaya, et al |
Communications in Mathematical Biology and Neuroscience |
Modelling/ prediction| Modélisation/prédiction Transmission |
In East Java, 11,910 confirmed incidences for COVID-19 were registered as of 30 June 2020. We propose a Geographically
Weighted Negative Binomial Regression (GWNBR) model to evaluate the effect of population density and daily average temperature on COVID-19 transmission. Our results reveal that the areas with high population density have much higher incidences than the areas
with a low population density. This result indicates the COVID-19 spread quickly in locations with high population density. So, achieving a reduction in the contact rate between uninfected and infected individuals by quarantined susceptible individuals can
effectively reduce disease transmission. However, the average temperature affect spatially only in several areas which shows that there is not enough evidence to explain the effect temperature on COVID-19 cases. © 2020 the author(s). |
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Friedrich, F, Ongaratto, et al |
Clin Infect Dis |
Public health interventions*| Interventions de santé publique |
BACKGROUND: Interventions to tackle the COVID-19 pandemic may affect the burden of other respiratory diseases. Considering
the repercussion of these unique social experiences in infant's health, this study aims to assess the early impact of social distancing due to the COVID-19 pandemic in hospital admissions for acute bronchiolitis. METHODS: Data from hospitalizations of acute
bronchiolitis in infants under one year were obtained from the Department of Informatics of the Brazilian Public Health database (DATASUS) for the period between 2016 and 2020. These data were also analyzed by macro-regions of Brazil (North, Northeast, Southeast,
South and Midwest). To evaluate the effect of social distancing strategy on the incidence of acute bronchiolitis, the absolute and relative reduction was calculated by analyzing the yearly subsets of 2016vs2020, 2017vs2020, 2018vs2020, and 2019vs2020. RESULTS:
There was a significant reduction in all comparisons, ranging from -78% IRR 0.22 (0.20 to 0.24)] in 2016vs2020 at -85% IRR 0.15 (0.13 to 0.16)] in 2019vs2020, for the data from Brazil. For analyzes by macro-regions, the reduction varied from -58% IRR 0.41
(0.37 to 0.45)] in the Midwest in 2016vs2020 to -93% IRR 0.07 (0.06 to 0.08)] in the South in 2019vs2020. CONCLUSIONS: There was a significant reduction in hospitalization for acute bronchiolitis in children under one year old, in Brazil, of the order of more
than 70% for most analysis. Our data suggest an important impact of social distance on reducing the transmission of viruses related to acute bronchiolitis. Such knowledge may guide strategies for prevention of viruses spread. |
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Modeling and Analysis of COVID-19 Based on Multi-isolation Strategy |
Fu, Q, Yao, et al |
Dongbei Daxue Xuebao/Journal of Northeastern University |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
Aiming at the outbreak of COVID-19 (corona virus disease 2019), considering multi-isolation measures, a non-linear
infectious disease model was established to study the trend of COVID-19. Comparing the data in China of the COVID-19 with the results of simulation experiments, the isolation measures are important for the prevention and control of COVID-19. The results showed
that if the isolation measures were implemented one week later, the number of infected persons in the entire epidemic would increase almost 7 times. In addition, the measure for newly confirmed clinical cases in Hubei Province is analyzed by simulation experiments.
The results showed that the measure effectively solved the problem of previously missed cases and can greatly speed up the extinction of the epidemic. Then, the subsequent official data of COVID-19 also agreed with the simulation results. © 2020, Editorial
Department of Journal of Northeastern University. All right reserved. |
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Fuentes-García, JP, Martínez Patiño, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
Chess is a sport characterized by high psychophysiological demands derived from long training durations, tournaments,
and games, leading to mental, emotional, and physical stress. These characteristics could provide chess players a certain advantage in facing quarantine situations. This study aimed to analyze the effect of COVID-19 confinement on behavioral, psychological,
and training patterns of chess players based on their gender, level of education, and level of chess played. Authors concluded that chess players, especially those with a higher academic level, might have adapted their psychological profile to fit confinement
situations and the worrying levels of physical inactivity |
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Fujiyoshi, K, Ako, et al |
J Nucl Cardiol |
Clinical data| Données cliniques |
COVID-19 case report of a 71-year old woman who presented to the hospital because of trivial fever and shortness of
breath lasting for 2 months. Her diagnosis of Tako-tsubo-like left ventricular (LV) dysfunction has been reported to occur concomitantly with COVID-19.1 The diagnosis of tako-tsubo can be a challenge when invasive catheterization cannot be readily indicated
in patients with COVID 19. |
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Treatment of Immunocompromised COVID-19 patients with Convalescent Plasma |
Fung, M, Nambiar, et al |
Transpl Infect Dis |
Clinical data| Données cliniques |
We describe our institutional experience with four immunosuppressed patients (two kidney transplant recipients, one
lung transplant recipient, and one chronic myelogenous leukemia patient) treated with COVID-19 convalescent plasma through Expanded Access Program (NCT04338360). All patients clinically improved after administration (two fully recovered and two discharged
to skilled nursing facilities) and none experienced a transfusion reaction. |
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Furnari, M, Eusebi, et al |
Gut |
Healthcare Response | Réponse des soins de santé |
We conducted a multicentre study to assess the decrease of GI and pancreato-biliary high-risk lesions detection consequent
to the reduction of the endoscopic activity. The lockdown period was compared to the equivalent timeframe of the previous 3 years. Endoscopic procedures decreased by 72.9% (elective 72.4% and urgent 51.3%); the overall cases of high-grade dysplasia/cancers
decreased by 59.1% (23.4% pancreato-biliary cancers; 70.6% and 68.8% upper and lower GI lesions). The postemergency period should aim at limiting high-risk lesions delayed diagnoses. |
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Derivative, regression and time series analysis in sars-cov-2 |
Furtado, P |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Derivatives, polynomial regression and time series analysis can be used to capture trends. In this paper we explore
and evaluate the use of such techniques, concluding regarding their merits and limitations for the Covid-19 data series. We conclude that polynomial regression on derivative totals, with degree 2 or 3 achieved the lowest average errors (median 5.5 to 6%) over
20 countries, while PROPHET and ARIMA may excel in larger series. |
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Social Distancing Causally Impacts the Spread of SARS-CoV-2: A Nationwide
U.S. Event Study |
Gagnon, Louis Joseph, Gagnon, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
We utilize the quasi-experimental setting created by the nationwide protests precipitated by George Floyd’s tragic
death on May 25, 2020, to assess the causal impact of social distancing on the spread of SARS-CoV-2. Methods: Our sample period spans from January 22, 2020, to June 20, 2020, and consists of 474,422 county-days representing 3,142 counties from all 50 states
and the District of Columbia. Findings: We document a country-wide increase of over 3 · 06 cases per day, per 100,000 population, following the onset of the protests and a further increase of 1 · 73 cases per day, per 100,000 population, in the counties in
which the protests took place ). Relative to the week preceding the onset of the protests, this represents a 61 · 2 % country-wide increase in the infection rate, and a further 34 · 6 % increase in the protest counties. |
|
Gale, P |
Microbial Risk Analysis |
Coronavirology| Coronavirologie |
A prototype thermodynamic equilibrium model is presented here for the probability of the virions getting through the
mucus barrier and infecting epithelial cells based on the binding affinity (Kmucin) of the virions to mucin molecules in the mucus and parameters for binding and infection of the epithelial cell. |
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Gambichler, T, Reuther, et al |
J Eur Acad Dermatol Venereol |
Clinical data| Données cliniques |
Data on SARS-CoV-2 detection in lesional skin is controversial.(1-8) We report a PCR-proven COVID-19 patient with a
chilblain-like SARS-CoV-2 positive skin lesion. An 80-year-old woman presented to the emergency department at the End of March 2020. She reported an onset of fever (38.4 C°) several days before admission, along with cough and shortness of breath. RT-PCR from
a nasopharyngeal swab was positive for SARS-CoV-2. An X-ray showed evidence for right-sided pneumonic infiltrates. |
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Gandini, O, Criniti, et al |
Journal of Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
Here we aimed to establish the most suitable panel for routine prognostic serum laboratory testing in COVID-19 patients
upon first admission to the Emergency Department. We enrolled 141 patients diagnosed as COVID-19 by means of real-time polymerase chain reaction testing and admitted to the isolation ward of Emergency Department at Policlinico Umberto I Hospital in Rome,
Italy, between March 2020 and June 2020. Serum samples were collected from patients upon admission before starting any treatment and tested by Laboratory Department. Our data strongly confirm that increased levels of ferritin were directly related with the
disease severity. Particularly, not only severe group showed 2.6 times higher ferritin levels than the mild group, but patients who needed admission to the ICU showed 5.8 times higher ferritin compared to patients with mild COVID-19. Among all parameters considered,
we also noted that the NLR was statistically correlated with the severity of disease. Conversely, D-D, LDH and CRP increased only in the group of critical patients, being substantially stable in the other groups characterized by mild, moderate and severe disease |
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Gao, X, Dong, et al |
J Am Med Inform Assoc |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
OBJECTIVE: Estimating the hospitalization risk for people with comorbidities infected by the SARS-CoV-2 virus is important
for developing public health policies and guidance. Traditional biostatistical methods for risk estimations require: (i) the number of infected people who were not hospitalized, which may be severely undercounted since many infected people were not tested;
(ii) comorbidity information for people not hospitalized, which may not always be readily available. We aim to overcome these limitations by developing a Bayesian approach to estimate the risk ratio of hospitalization for COVID-19 patients with comorbidities.
MATERIALS AND METHODS: We derived a Bayesian approach to estimate the posterior distribution of the risk ratio using the observed frequency of comorbidities in COVID-19 patients in hospitals and the prevalence of comorbidities in the general population. We
applied our approach to two large-scale datasets in the United States: 2491 patients in the COVID-NET, and 5700 patients in New York hospitals. RESULTS: Our results consistently indicated that cardiovascular diseases carried the highest hospitalization risk
for COVID-19 patients, followed by diabetes, chronic respiratory disease, hypertension, and obesity, respectively. DISCUSSION: Our approach only needs (i) the number of hospitalized COVID-19 patients and their comorbidity information, which can be reliably
obtained using hospital records, and (ii) the prevalence of the comorbidity of interest in the general population, which is regularly documented by public health agencies for common medical conditions. CONCLUSION: We developed a novel Bayesian approach to
estimate the hospitalization risk for people with comorbidities infected with the SARS-CoV-2 virus. |
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Gao, X, Qin, et al |
Acta Pharmaceutica Sinica B |
Coronavirology| Coronavirologie |
In this study, we sought to provide structural frameworks for PLpro inhibitor design. We determined the unliganded
structure of SARS-CoV-2 PLpro mutant C111S, which shares many structural features of SARS-CoV PLpro. Our results suggest a mechanism of GRL0617 inhibition, that GRL0617 not only occupies the substrate pockets, but also seals the entrance to the substrate
binding cleft hence prevents the binding of the LXGG motif of the substrate. |
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García Bascones, M, Puentes Gutiérrez, et al |
Rehabilitacion |
Healthcare Response | Réponse des soins de santé |
This study analyses both the impact of the pandemic and clinical and teaching organisation in Spanish Physical Medicine
and Rehabilitation Departments during the COVID-19 pandemic. Almost half of the departments cancelled face-to-face medical consultations (40%) and 48% of the treatment rooms were turned into COVID beds. In 30 hospitals (55.6%), the physicians worked in COVID
units. Most of the rehabilitation departments developed both graphic and audiovisual material with exercises, referral protocols and guidelines for the rehabilitation management and treatment of COVID 19 patients. Half of the departments reported some anxiety
symptoms in medical staff. Tutorial work has been cancelled (40.7%) or reduced (35.2%). |
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García-Ordás, MT, Arias, et al |
Healthcare (Basel) |
Public Health response| Interventions de santé publique |
In this study, the eating habits of 170 countries were evaluated in order to find correlations between these habits
and mortality rates caused by COVID-19 using machine learning techniques that group the countries together according to the different distribution of fat, energy, and protein across 23 different types of food, as well as the amount ingested in kilograms. Results
shown how obesity and the high consumption of fats appear in countries with the highest death rates, whereas countries with a lower rate have a higher level of cereal consumption accompanied by a lower total average intake of kilocalories. |
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Gautam, AS, Dilwaliya, et al |
Environment, Development and Sustainability |
Public health interventions*| Interventions de santé publique |
Due to fast and deadly spread of corona virus (COVID-19), the Government of India implemented lockdown in the entire
country from 25 April 2020. So, we studied the differences in the air quality index (AQI) of Delhi (DTU, Okhla and Patparganj), Haryana (Jind, Palwal and Hisar) and Uttar Pradesh (Agra, Kanpur and Greater Noida) from 17 February 2020 to 4 May 2020. The AQI
was calculated by combination of individual sub-indices of seven pollutants, namely PM2.5, PM10, NO2, NH3, SO2, CO and O3, collected from the Central Pollution Control Board website. The AQI has improved by up to 30–46.67% after lockdown. The AQI slope values
− 1.87, − 1.70 and − 1.35 were reported for Delhi, − 1.11, − 1.31 and − 1.04 were observed for Haryana and − 1.48, − 1.79 and − 1.78 were found for Uttar Pradesh (UP), which may be attributed to limited access of transportation and industrial facilities due
to lockdown. The ozone (O3) concentration was high at Delhi because of lesser greenery as compared to UP and Haryana, which provides higher atmospheric temperature favourable for O3 formation. The air mass back trajectory (AMBT) analysis reveals the contribution
of air mass from Europe, Africa and Gulf countries as well as local emissions from Indo-Gangetic Plain, Madhya Pradesh and Maharashtra states of India. |
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Experiences of commercial sex workers during COVID-19 restrictions in selected metropolises in
Ghana |
Gbagbo, FY |
Health Care Women Int |
Public Health response| Interventions de santé publique |
The author examined experiences of Commercial Sex Workers (CSWs) in Accra, Kumasi and Kasoa metropolises following
Ghana’s imposition restrictive ACT since 21 March 2020. Three trained male field assistants posing as mystery clients, purposively selected and interviewed 35 CSWs using a combination of face-to-face and telephone interviews with consenting CSWs in the study
area. Findings show declined activity and patronage of CSWs due to fear of contracting COVID-19. With no savings or other reliable sources of income, some CSWs have however devised various strategies to work safely and implored the government to support them
financially during this crisis. |
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Ghimire, P, Dhungel, et al |
Journal of Nepal Health Research Council |
Healthcare Response | Réponse des soins de santé |
The study aims to determine the knowledge, attitude and practices among healthcare workers. The survey findings showed
deficiencies in knowledge and appropriate practice among the HCWs, in prevention of SARS-CoV-2 transmission. Attitudes towards COVID19 were a mix of both positive and negative viewpoints. Even in health care workers with access to internet, there is significant
gap in universal infection prevention and control practices required for self-protection and limiting untoward transmission. |
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Ghoneim, S, Butt, et al |
Metabol Open |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study is to determine the relationship between metabolic syndrome components and the risk of COVID-19.
In the United States, the incidence of COVID-19 among patients with metabolic syndrome or its components is high. Non-alcoholic steatohepatitis (NASH) is associated with the highest risk of COVID-19. African Americans are disproportionately affected by COVID-19. |
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Gil-Alana, L, Poza, et al |
Tourism Economics |
Economics | Économie |
We examine in this note the impact of COVID-19 on the Spanish tourism sector by using a strong dependence model. Daily
data from five equity markets are used and we find that the coronavirus crisis has increased the persistence in the data, moving in some of the series from a mean reverting process to a non-mean reverting one. Thus, shocks that were expected to be transitory
have become permanent, implying the need of strong policy measures to come the series back to their long-term projections. |
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The Impact of the COVID-19 Pandemic on the Mental Health and Wellbeing of UK Healthcare
Workers |
Gilleen, James, Santaolalla, et al |
SSRN- Lancet prepublication |
Healthcare Response | Réponse des soins de santé |
This study aims to understand the psychological impact of the pandemic on UK HCW and identify factors which raise risk
of, or protect against, poor mental health during the pandemic. A large proportion of UK HCW reported high levels of mental health symptoms. Wellbeing, particularly of frontline workers (FL), had significantly worsened compared to pre-COVID-19 levels. Specific
clusters of factors conferred risk of high symptoms. ‘Fixed’ factors included being female, being FL, pre-existing mental health diagnosis, and experience of stressful/traumatic events. An additional set of controllable factors also significantly increased
risk of high symptoms: PPE, workplace preparation, workload, and sufficient COVID-19 training and information. Resilience and sharing stress reduced risk, as did ethics panel support for those making decisions about patient treatment. Allied HCW and especially
managers were at risk of high symptoms, particularly PTSD. BAME HCWs were significantly at risk of high PTSD and were more worried than non-BAME about COVID and PPE. |
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Impact of COVID-19 Pandemic on Drug Overdoses in Indianapolis |
Glober, N, Mohler, et al |
J Urban Health |
Public Health response| Interventions de santé publique |
We described the change in drug overdoses during the COVID-19 pandemic in one urban emergency medical services (EMS)
system. Data was collected from Marion County, Indiana (Indianapolis), including EMS calls for service (CFS) for suspected overdose, CFS in which naloxone was administered, and fatal overdose data from the County Coroner’s Office. Overdose CFS and EMS naloxone
administration showed an increase with the social isolation of the Indiana stay-at-home order, but a continued increase after the stay-at-home order was terminated. Despite a mild 4% increase in all EMS CFS, overdose CFS increased 43% and CFS with naloxone
administration increased 61% after the stay-at-home order. Deaths from drug overdoses increased by 47%. There was no change in distribution of age, race/ethnicity, or zip code of those who overdosed after the stay-at-home order was issued. |
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COVID-19 and Lockdown: Impact on Mental Health Among the Residents of Assam, India |
Gogoi, AJ, Sarmah, et al |
Asia Pac J Public Health |
Public Health response| Interventions de santé publique |
Cross-sectional survey was conducted from May 8 to 18, 2020, using snowball sampling technique to understand the impact
of the novel coronavirus disease (COVID-19) pandemic and resulting lockdown on the mental health of the people of Assam. Data on demography and mental health status during the lockdown period were collected using online questionnaire. Assessment of mental
health status was done using the Depression, Anxiety and Stress Scale (DASS-21). Frequency of individuals with moderate to extremely severe depression, anxiety, and stress was quite higher than the results obtained during the National Mental Health Survey
of India, 2016. Thus, appropriate intervention by mental health professionals is needed to help the population deal with the crisis. |
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Binding of SARS-CoV-2 to cell receptors: a tale of molecular evolution |
Gomez, SA, Rojas-Valencia, et al |
Chembiochem |
Coronavirology| Coronavirologie |
The magnified infectious power of the SARS–CoV–2 virus compared to its precursor SARS–CoV is intimately linked to an
enhanced ability in the mutated virus to find available hydrogen bond sites in the host cells. This characteristic is acquired during virus evolution because of the selective pressure exerted at the molecular level. We pinpoint the specific residue (in the
virus) to residue (in the cell) contacts during the initial recognition and binding and show that the virus· · · cell interaction is mainly due to an extensive network of hydrogen bonds and to a large surface of non–covalent interactions. In addition to the
formal quantum characterization of bonding interactions, computation of absorption spectra for the specific virus· · · cell interacting residues yields significant shifts of ∆λ max = 47 and 66 nm in the wavelength for maximum absorption in the complex with
respect to the isolated host and virus, respectively. |
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Gouda, W, Yasin, et al |
Egyptian Journal of Radiology and Nuclear Medicine |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We aimed to assess the validity of computed tomography (CT) quantitative and qualitative analysis in COVID-19 pneumonia
and how it can predict the disease severity on admission. Advances in CT COVID-19 pneumonia assessment provide an accurate and rapid tool for severity assessment, helping for decision-making notably for the critical cases. |
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Interactive intervention on handwashing among elementary school children |
Grewal, M, Krishna, et al |
Health Behavior and Policy Review |
Public health interventions*| Interventions de santé publique |
This study was conducted in 3 elementary schools in Seattle, Washington to assess children's knowledge about microbe
transmission and handwashing and to evaluate the effectiveness of an educational intervention about handwashing. Our study identified important knowledge gaps about microbial transmission and handwashing in elementary school children. We showed that an educational
intervention can be effective in improving knowledge about handwashing. |
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Guerrero-Torres, L, Caro-Vega, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We evaluated the risk of death of healthcare workers (HCW) with SARS-CoV-2 infection in Mexico City during the COVID-19
pandemic and described the associated factors in hospitalized HCW compared with non-HCW. Compared with non-HCW, HCW were more frequently female, younger and free of comorbidities. Overall, 25,771 (20.5%) were treated as inpatients and 11,182 (8.9%) deaths
were reported. Deaths in the total population and in hospitalized patients were significantly higher in non-HCW than in HCW (9.9% vs 1.9%, P<.001; and 39.6% vs 19.3%, P<.001, respectively). In hospitalized patients, using a multivariate model, the risk of
death in HCW in general was lower (OR 0.53) compared to non-HCW, and by specific occupation, in physicians, nurses and other HCW risk was OR 0.60, 0.29, 0.61, respectively. |
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Risk stratification for prediction of spread and severity by covid-19 in brazilian federation units |
Guimarães, RM, Eleuterio, et al |
Revista Brasileira de Estudos de Populacao |
Epidemiology| Épidémiologie |
This study carried out risk stratification for the dissemination and severity of Covid-19 in the units of the Brazilian
Federation (UF) based on characteristics identified as risk situations. The components refer to assistance, health (including risk factors), demographic and social conditions. These components allowed the final classification of the 27 FU, with a difference
in order as to the potential for dissemination and mortality. |
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Guiot, J, Henket, et al |
Respiratory Investigation |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We retrospectively analyzed a cohort of 401 patients with interstitial lung diseases (ILD) and determined the proportion
of patients hospitalized for proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and specific symptoms of COVID-19. We found that 1% of patients (n = 4) were hospitalized (1 in ICU) for COVID-19. In total, 310 of the 401 patients
answered the phone call. Only 33 patients (0.08%) experienced specific symptoms of SARS-CoV-2 infection. Our study did not demonstrate any increased occurrence of severe COVID-19 in ILD patients compared to the global population. Based on our findings, we
could not make any conclusion on the incidence rate of SARS-CoV-2 infection in patients with ILDs, or on the overall outcome of immunocompromised patients affected by COVID-19. |
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Analysis of liver injury factors in 332 patients with COVID-19 in Shanghai, China |
Guo, H, Zhang, et al |
Aging (Albany NY) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We analyzed clinical parameters and risk factors for coronavirus disease 2019 (COVID-19)-related liver damage. Of the
332 COVID-19 patients, 98 (29.5%) were admitted with liver injury. The rates of aspartate transaminase, γ-glutamyl transpeptidase, and total bilirubin abnormalities were higher in the critical group than in the non-critical group. The patient’s sex, COVID-19
severity, and a low liver CT density strongly correlated with liver injury (ORs: 2.936, 6.543, and 3.387, respectively). Statistical analysis on drug administration after admission showed that the usage rates of lopinavir/ritonavir, glucocorticoids, and thymopeptides
were significantly higher in the abnormal group than the normal groups (p<0.05). |
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Guo, J, Zhou, et al |
Epidemiol Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study is to identify a simplified risk score that could easily be used to quickly triage severe
COVID-19 patients. We observed that: Compared with survivors, nonsurvivors were older and illustrated higher respiratory rate, neutrophil-to-lymphocyte ratio, D-dimer, and LDH, but lower SpO2 as well as impaired liver function, especially synthesis function.
CURB-65 showed good performance for predicting in-hospital death (AUC 0.81, 95% CI 0.71 to 0.91). CURB-65 ≥ 2 may serve as a cut-off value for prediction of in-hospital death in severe patients with COVID-19(Sensitivity 68%, Specificity 81%, F1 score 0.7).
CURB-65(HR 1.61; 95%CI 1.05 – 2.46), LDH (HR 1.003; 95%CI 1.001 – 1.004), and albumin (HR 0.9; 95%CI 0.81 – 1) were risk factors for in-hospital death in severe patients with COVID-19. Our study indicates CURB-65 may serve as a useful prognostic marker in
COVID-19 patients, which could be used to quickly triage severe patients in primary care or general practice setting |
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Alarmin S100A8/A9 Mediates Activation of Aberrant Neutrophils in the Pathogenesis
of COVID-19 |
Guo, Qirui, Zhao, et al |
SSRN- Lancet prepublication |
Therapeutics| Thérapeutique Animal model | Modèle animal |
We characterized the transcriptome of rhesus macaques and mice infected with SARS-CoV-2. Alarmin S100A8 was robustly
induced by SARS-CoV-2 in animal models as well as in COVID-19 patients. Paquinimod, a specific inhibitor of S100A8/A9, could reduce inflammatory response and rescue the pneumonia with substantial reduction of viral titers in SASR-CoV-2 infected animals. Remarkably,
Paquinimod treatment resulted in 100% survival of mice in a lethal model of mouse coronavirus (MHV) infection. A novel group of neutrophils that contributed to the uncontrolled inflammation and onset of COVID-19 were dramatically induced by coronavirus infections.
Paquinimod treatment could reduce these neutrophils and regain antiviral responses, unveiling key roles of S100A8/A9 and noncanonical neutrophils in the pathogenesis of COVID-19, highlighting new opportunities for therapeutic intervention. |
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Hägg, S, Jylhävä, et al |
Journal of the American Medical Directors Association |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To analyze whether frailty and comorbidities are associated with in-hospital mortality and discharge to home in older
adults hospitalized for coronavirus disease 2019 (COVID-19). Of all geriatric patients with COVID-19, 3 out of 4 survived during the study period. Our results indicate that in addition to age, the level of frailty is a useful predictor of short-term COVID-19
outcomes in geriatric patients. |
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32969371; Perspective of Doctors for COVID-19 Pandemic Readiness in Government Hospitals of Nepal |
Hamal, PK, Pokhrel, et al |
Journal of Nepal Health Research Council |
Healthcare Response | Réponse des soins de santé |
The study assesses the perspective of doctors working in government hospitals of Nepal regarding hospital preparedness
for infection prevention measures, isolation services provisions, critical care service readiness, and training of staff for COVID-19 pandemic management. Findings show that majority of medical doctors working in government hospitals of Nepal perceive that
provision of facemask distribution, airborne isolation rooms, critical care preparedness, and hands-on training to staff were not adequate. |
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Lung Expression of Human ACE2 Sensitizes the Mouse to SARS-CoV-2 Infection |
Han, K, Blair, et al |
Am J Respir Cell Mol Biol |
Animal model | Modèle animal |
Herein we report development and characterization of a rapidly deployable COVID-19 mouse model. C57BL/6J (B6) mice
expressing hACE2 in the lung were transduced by oropharyngeal delivery of the recombinant human adenovirus type 5 that expresses hACE2 (Ad5-hACE2). Results demonstrate that expression of hACE2 via adenovirus delivery system sensitized the mouse to SARS-CoV-2
infection and resulted in the development of a mild COVID-19 phenotype, highlighting the immune and inflammatory host responses to SARS-CoV-2 infection. |
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Willingness-to-pay for a COVID-19 vaccine and its associated determinants in Indonesia |
Harapan, H, Wagner, et al |
Hum Vaccin Immunother |
Public Health response| Interventions de santé publique |
We undertook an online survey to measure the willingness-to-pay (WTP) for a COVID-19 vaccine and its determinants in
Indonesia. In total, 78.3% (1,065) were willing to pay for the COVID-19 vaccine with a mean and median WTP of US$ 57.20 (95%CI: US$ 54.56, US$ 59.85) and US$ 30.94 (95%CI: US$ 30.94, US$ 30.94), respectively. Being a health-care worker, having a high income,
and having high perceived risk were associated with higher WTP. These findings suggest that the WTP for a COVID-19 vaccine is relatively high in Indonesia. This WTP information can be used to construct a payment model for a COVID-19 vaccine in the country.
Nevertheless, to attain higher vaccine coverage, it may be necessary to partially subsidize the vaccine for those who are less wealthy and to design health promotion materials to increase the perceived risk for COVID-19 in the country. |
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Retarded decline of the share of SARS-CoV-2-positive children in North Rhine-Westphalia, Germany |
Häusler, M, van Helden, et al |
J Med Virol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Compared with adults children are less affected by SARS‐CoV‐2 infections and are unlikely to account for the initial
viral spread. However, children show sustained viral activity and may serve as a viral reservoir. |
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In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study |
Hayek, SS, Brenner, et al |
Bmj |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This multicenter cohort study from the USA estimates the incidence, risk factors, and outcomes associated with in-hospital
cardiac arrest and cardiopulmonary resuscitation in critically ill adults with coronavirus disease 2019 (covid-19). Findings show that cardiac arrest is common in critically ill patients with covid-19 and is associated with poor survival, particularly among
older patients. |
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Study on epidemic prevention and control strategy of COVID-19 based on personnel flow prediction |
He, P |
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Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this paper, a COVID-19 risk prevention and control decision-making model is proposed according to the incompatible
characteristics of epidemic risk prediction. Firstly, the uncertainty attribute of epidemic risk was analyzed through the collection of information on the personnel flow, and the problem that the risk of the epidemic could not be accurately predicted due to
the uncertainty of the personnel flow was solved, and emergency prevention and control countermeasures were proposed for the possible COVID-19. Secondly, a model of epidemic risk prevention and control analysis is established by using correlation function
method, which provides a new research method for risk prevention and control of public health security. |
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Hess, CB, Buchwald, et al |
Cancer |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Researchers at Emory University report preliminary safety outcomes for patients treated with low‐dose lung irradiation
for coronavirus disease 2019 (COVID‐19) pneumonia. Five residents of nursing or group homes were hospitalized after testing positive for COVID‐19. Each had pneumonia visible on a chest x‐ray, required supplemental oxygen, and experienced a clinical decline
in mental status or in work of breathing or a prolonged or escalating supplemental oxygen requirement. |
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Higham, JE, Ramírez, et al |
Air Quality, Atmosphere and Health |
Public health interventions*| Interventions de santé publique |
We use data from official UK air-quality sensors (DEFRA AURN) and the UK Met Office stations to show how lockdown measures
affected air quality in the UK. We compare the 100 days post-lockdown (23 March to 30 June 2020) with the same period from the previous 7 years. We find, as shown in numerous studies of other countries, the nitrogen oxides levels across the country dropped
substantially (∼ 50%). However, we also find the ozone levels
increased (∼ 10%), and the levels of sulphur dioxide more
than doubled across the country. These changes, driven by a complex balance in the air chemistry near the surface, may reflect the influence of low humidity as suggested by Met Office data, and potentially, the reduction of nitrogen oxides and their interactions
with multiple pollutants. |
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Hill, WC, Hull, et al |
Nano Lett |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Shortages in the availability of personal protective |
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Intensity of anticoagulation and survival in patients hospitalized with COVID-19 pneumonia |
Hsu, A, Liu, et al |
Thrombosis research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objectives: Assess the outcomes and laboratory trends in COVID-19 patients stratified by intensity of anticoagulation
at time of admission. Between 27 February and 24 April 2020, 468 patients were hospitalized. Initial use of high-intensity thromboprophylaxis was associated with improved 30-day mortality (adjusted RR 0.26; 95% confidence interval [CI], 0.07–0.97; p = 0.045)
without a significant increased rate of bleeding (p = 0.11). In severe COVID-19, D-dimer significantly increased during hospitalization with standard thromboprophylaxis (p < 0.001) but remained stable or decreased with high-intensity prophylaxis or therapeutic
anticoagulation. |
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Hsu, AlanCY, Wang, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here we demonstrate that 2019 SARS-CoV-2 spike protein subunit 1 (CoV2-S1) induces high levels of NF-κB activations,
production of pro-inflammatory cytokines and mild epithelial damage, in human bronchial epithelial cells. We developed an antagonistic peptide that inhibits S1-ACE2 interaction and CoV2-S1-induced productions of pro-inflammatory cytokines. The existing FDA-approved
ER stress inhibitor, 4-phenylburic acid (4-PBA), and MAP kinase inhibitors, trametinib and ulixertinib, ameliorated CoV2-S1-induced inflammation and epithelial damage. |
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Surveillance and re-Positive RNA test in Patients recovered from COVID-19 |
Hu, J, Li, et al |
J Med Virol |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
We prospectively analyzed 117 hospitalized patients with mild pneumonia in Wuhan Fangcang Hospital. Eight patients
(6.8%) showed re‐positive test after a median 12.5 (11.8‐16.3) days. Seven of them were asymptomatic. No new transmission have been observed |
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Emergency response to COVID-19 epidemic: One Chinese blood centre's experience |
Hu, P, Kang, et al |
Transfus Med |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
The objective of this study was to demonstrate the emergency response of a Chinese blood centre on maintaining both
the safety and the sufficiency of blood supply during large, emerging, infectious epidemics. Early on in the outbreak of COVID‐19, the Chengdu Blood Center developed strategies and implemented a series of measures, including enhanced recruitment efforts, addition
of new donation deferral criteria and notification after donation, optimisation of donor experience, development and implementation of a new coronavirus nucleic acid detection technology platform for blood screening and screening all donations for SARS‐CoV‐2
RNA to maximumly protect the safety of blood supply during a time of unclear risk. Starting on February 20, the immediate satisfaction rate of blood product orders in Chengdu city's clinical settings reached 100%, and there was no case of blood transfusion
infection. |
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Who Are the `Silent Spreaders'?: Contact Tracing in Spatio-Temporal Memory Models |
Hu, Yue, Subagdja, et al |
ArXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This paper presents a neural network model called Spatio-Temporal Episodic Memory for COVID-19 tracing (STEM-COVID)
for identifying ACCs from contact tracing data. Based on fusion Adaptive Resonance Theory (fusion ART), STEM-COVID provides a mechanism to encode the collective spatio-temporal episodic memory traces of individuals, based on which parallel searches of asymptomatic
COVID-19 cases (ACCs) can be performed in a computationally efficient manner by pooling together the episodic traces of the identified positive cases. To illustrate the effectiveness of STEM-COVID, a simulation model of the COVID-19 spreading is implemented
based on recent epidemiological findings on ACCs. The experimental results based on multiple simulation scenarios show that the STEM-COVID model is able to identify ACCs with a reasonably high level of accuracy and efficiency. |
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Huang, L, Liu, et al |
GeoHealth |
Public health interventions*| Interventions de santé publique |
In this study, we apply a widely used exposure-response function to estimate the short-term health impacts associated
with PM2.5 changes over the Yangtze River Delta (YRD) region due to COVID-19 lockdown. Concentrations of PM2.5 during lockdown period reduced by 22.9% to 54.0% compared to pre-lockdown level. Estimated PM2.5-related daily premature mortality during lockdown
period is 895 (95% confidential interval: 637–1,081), which is 43.3% lower than pre-lockdown period and 46.5% lower compared with averages of 2017–2019. Avoided premature mortality is mostly contributed by reduced death associated with stroke (16.9 thousand,
accounting for 40.0%), ischemic heart disease (14.0 thousand, 33.2%), and chronic obstructive pulmonary disease (7.6 thousand, 18.0%). |
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Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain |
Huang, PH, Tsai, et al |
Hum Vaccin Immunother |
Vaccine Research| Recherche sur les vaccins Animal model | Modèle animal |
Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response
and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays. |
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Ianiro, G, Bibbò, et al |
Dig Liver Dis |
Healthcare Response | Réponse des soins de santé |
Of 26 patients evaluated for Fecal microbiota transplantation (FMT), 21 were treated for recurrent or refractory Clostridioides
difficile infection (CDI). Eighteen patients completed the 8-week follow-up, and no one recurred after FMT. Follow-up is ongoing in 3 patients, although in all of them diarrhea disappeared after the first procedure. No serious adverse events were reported.
Two patients had also COVID-19-related pneumonia, and were cured both from CDI and COVID-19. |
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Infant Reshawn, M, Abilasha, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
The aim of the study is to assess the awareness about COVID-19 symptoms among school teachers and students to improve
the knowledge among the teaching fraternity in educational institutions. A survey-based questionnaire was prepared to assess the awareness about the symptoms of COVID-19.The overall awareness for all subgroups was fair. The highest percentage of cor-rect responses
were from the teachers compared to students. |
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In-silico design of a potential inhibitor of SARS-CoV-2 S protein |
Jaiswal, G, Kumar, et al |
PLoS One |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We have designed a protein inhibitor (ΔABP-D25Y) targeting S protein using computational approach. The inhibitor consists
of two α helical peptides homologues to protease domain (PD) of ACE2. Docking studies and molecular dynamic simulation revealed that the inhibitor binds exclusively at the ACE2 binding site of S protein. The computed binding affinity of the inhibitor is higher
than the ACE2 and thus will likely out compete ACE2 for binding to S protein. Hence, the proposed inhibitor ΔABP-D25Y could be a potential blocker of S protein and receptor binding domain (RBD) attachment. |
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First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients
(LEOSS)" |
Jakob, CEM, Borgmann, et al |
Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66–85 years (39.6%; 500/2,155).
The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor
therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46–65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25–2.42, p = 0.001; 66–85 years: aOR
1.93, 95% CI 1.36–2.74, p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49–3.81, p < 0.001 vs. individuals aged 26–45 years], male sex (aOR 1.23, 95% CI 1.01–1.50, p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09–1.72, p = 0.007), and diabetes (aOR 1.33,
95% CI 1.04–1.69, p = 0.023) were associated with complicated stages of COVID-19 at diagnosis. |
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Jansen, Gerrit, Ebeling, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
Objective: To evaluate the effects of European Resuscitation Council (ERC) Covid-19-guidelines on resuscitation quality.
Covid-19-guidelines led to earlier attempts at intubation, delay in starting chest compressions, longer interruption in chest compression and markedly worsen the quality of resuscitation. These negative effects are attenuated by increasing the number of staff
and addition of an experienced airway manager. Specific indications for Covid-19-guidelines are urgently required to carefully balance the risk of infection with SARS-CoV-2 for the staff vs. the potentially worse outcome for the patients. |
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Jardine, J, Relph, et al |
Bjog |
Healthcare Response | Réponse des soins de santé |
Objective: To explore the modifications to maternity services across the UK, in response to the COVID‐19 pandemic,
in the context of the pandemic guidance issued by the Royal College of Obstetricians and Gynaecologists (RCOG), Royal College of Midwives (RCM) and NHS England. 81 respondent sites, 42% of 194 obstetric units in the UK, were included. They reported substantial
and heterogeneous maternity service modifications. 70% of units reported a reduction in antenatal appointments and 56% in postnatal appointments; 89% reported using remote consultation methods. 70% reported a change to screening pathways for gestational diabetes
mellitus. 59% had temporarily removed the offer of births at home or in a midwife‐led unit. 86% of units experienced a reduction in emergency antenatal presentations. |
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Self-Assessment Questionnaire for Efficient and Safe Evaluation of Patients with
Mild COVID-19 |
Jeong, H, Lee, et al |
Infection and Chemotherapy |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We developed and evaluated a self-assessment questionnaire consisting of 23 symptoms with linear-scale scores from
0 to 10. Patients were asked to indicate their worst score for each symptom daily, and medical personnel assessed clinical improvement or deterioration based on the changes in scores. |
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Jin, W, Zhang, et al |
International journal of biological macromolecules |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In the current study, a series of polysaccharides from Saccharina japonica were prepared to investigate the structure-activity
relationship on the binding abilities of polysaccharides (oligosaccharides) to pseudotype particles, including SARS-CoV-2 SGPs, and ACE2 using surface plasmon resonance. Sulfated galactofucan (SJ-D-S-H) and glucuronomannan (Gn) displayed strongly inhibited
interaction between SARS-CoV-2 SGPs and heparin while showing negligible inhibition of the interaction between SARS-CoV-2 SGPs and ACE2. The IC50 values of SJ-D-S-H and Gn in blocking heparin SGP binding were 27 and 231 nM, respectively. NMR analysis showed
that the structure of SJ-D-S-H featured with a backbone of 1, 3-linked α-L-Fucp residues sulfated at C4 and C2/C4 and 1, 3-linked α-L-Fucp residues sulfated at C4 and branched with 1, 6-linked β-D-galacto-biose; Gn had a backbone of alternating 1, 4-linked
β-D-GlcAp residues and 1, 2-linked α-D-Manp residues. The sulfated galactofucan and glucuronomannan showed strong binding ability to SARS-CoV-2 SGPs, suggesting that these polysaccharides might be good candidates for preventing and/or treating SARS-CoV-2. |
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Jo, Y, Jamieson, et al |
medRxiv |
Economics | Économie |
Remdesivir for non-ventilated patients and dexamethasone for ventilated patients was estimated to result in 1,111 deaths
averted (assuming a 0-30% efficacy of remdesivir) compared to standard care, and save $11.5 million. The result was driven by the efficacy of the drugs, and the reduction of ICU-time required for patients treated with remdesivir. The scenario of dexamethasone
alone to ventilated and non-ventilated patients requires additional $159,000 and averts 1,146 deaths, resulting in $139 per death averted, relative to standard care. |
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Johnson, JK, Lapin, et al |
Phys Ther |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Patients with COVID-19 demonstrated improved mobility at hospital discharge and higher probability of discharging home
with increased frequency and longer mean duration of physical therapy visits. These associations were not generally moderated by patient characteristics. |
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|
Jonat, B, Gorelik, et al |
Pediatr Crit Care Med |
Healthcare Response | Réponse des soins de santé |
Our objective was to develop a clinical inpatient protocol for the evaluation, management, and follow-up of patients
with multisystem inflammatory syndrome in children. Key elements of evaluation include case identification using broad clinical characteristics and comprehensive laboratory and imaging investigations. Treatment centers around glucocorticoids and IV immunoglobulin
with biologic immunomodulators as adjuncts. Multidisciplinary follow-up after discharge is indicated to manage continued outpatient therapy and evaluate for disease sequelae. In nearly 2 months, we admitted 54 patients with multisystem inflammatory syndrome
in children, all of whom survived without the need for invasive ventilatory or mechanical circulatory support. After institution of this protocol, patients received earlier treatment and had shorter lengths of hospital stay. |
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Jones, BryanE, Brown-Augsburger, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique Animal model | Modèle animal |
Herein, we report that high-throughput microfluidic screening of antigen-specific B-cells led to the identification
of LY-CoV555, a potent anti-spike neutralizing antibody from a convalescent COVID-19 patient. Biochemical, structural, and functional characterization revealed high-affinity binding to the receptor-binding domain, ACE2 binding inhibition, and potent neutralizing
activity. In a rhesus macaque challenge model, prophylaxis doses as low as 2.5 mg/kg reduced viral replication in the upper and lower respiratory tract. These data demonstrate that high-throughput screening can lead to the identification of a potent antiviral
antibody that protects against SARS-CoV-2 infection. |
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“How Long Will Covid-19 Last?” And Other Questions Youth Ask Physicians about COVID-19 |
Jones, V, Johnson, et al |
Health Behavior and Policy Review |
Public Health response| Interventions de santé publique |
In this investigation, we identify the questions youth in a low-income urban community asked healthcare providers about
COVID-19. During the 3 town halls, there were 143 participants who asked 43 questions that were divided into 4 codes: Healthcare, Cure, General COVID-19, and Prevention. |
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Juan, Y, Yuanyuan, et al |
Comprehensive psychiatry |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to monitor the psychological distress in hospital staff and examine the relationship between
the psychological distress and possible causes during the COVID-19 epidemic. A total of 456 respondents completed the questionnaires with a response rate of 91.2%. Of the staff surveyed, 43.2% had stress reaction syndrome. The highest prevalence of psychological
distress was obsessive-compulsive symptoms (OCS)(37.5%), followed by somatization symptoms (33.3%), anxiety symptoms (31.6%), and depression symptoms (29.6%). |
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Kahyaoglu Sut, H, Kucukkaya, et al |
Perspect Psychiatr Care |
Public Health response| Interventions de santé publique |
This cross‐sectional study was conducted on 403 pregnant women using a web‐based survey. The hospital anxiety and depression
scale was used to measure anxiety and depression.The prevalence of anxiety and depression was 64.5% and 56.3%, respectively. Working status, physical activity status, discomfort with hospital visits, having information about COVID‐19, and being informed by
healthcare workers about COVID‐19 were factors related to anxiety (p < .05). Education level, physical activity status, discomfort with hospital visits, and having information about COVID‐19 were factors related to depression (p < .05). |
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Kainth, MK, Goenka, et al |
Pediatrics |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Sixty-five patients were identified. Among children who are hospitalized for COVID-19, most are younger than 60 days
or older than 12 years of age.. Fever was present in 86% of patients, lower respiratory symptoms or signs in 60%, and gastrointestinal symptoms in 62%. Thirty-five percent of patients required ICU care. The white blood cell count was elevated in severe disease
(P = .0027), as was the C-reactive protein level (P = .0192), compared with mild and moderate disease. Respiratory support was required in 34% of patients. Severity was lowest in infants younger than 60 days of age and highest in chronically ill children;
79% of immunocompromised children had mild disease. One death was reported. |
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Knowledge and awareness of COVID-19 symptoms among dental students-a questionnaire based survey |
Kallivayalil, JG, Abilasha, et al |
International Journal of Research in Pharmaceutical Sciences |
Healthcare Response | Réponse des soins de santé |
The aim of the survey was to assess the knowledge and awareness among dental professionals towards COVID-19 and reduce
the spread among patients and co-workers. A crosssectional study was conducted in a sample of 100 dental students by means of a questionnaire, using google forms. 24.8% prefer and rely on the fact that fever has been the main symptoms of COVID-19 while 32.7%
of the respondents prefer on the fact that cough has been the symptoms leading to COVID-19 64% of the dental students are aware on the fact that patients should be checked on their temperature before the consultation. 36.3% of the dental students prefer no
checking of temperature before the consultation. |
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The impact of COVID-19 quarantine on children‘s behaviors and language |
Kamal, SM, Al-Samydai, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
The questionnaire contained 36 questions regarding the impact of COVID-19 quarantine on children‘s behaviors and language
have been distributed online (Google form). Results showed that quarantine has an impact on children‘s behaviors and language, where stress and isolationism has a higher effect, while social relations had no impact. The majority of the respondents (75.0%)
had confidence that community pharmacies can play an important role in helping families in protection their children‘s behaviors and language as they made the highest contact with pharmacists during quarantine. |
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Tocilizumab Therapy of COVID-19: A Comparison of Subcutaneous
and Intravenous Therapies |
Kaminski, MA, Sunny, et al |
Int J Infect Dis |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study aimed to compare the effects of intravenous (IV) and subcutaneous (SC) tocilizumab, an IL-6 receptor antagonist,
on respiratory parameters and clinical outcome in patients with COVID 19. Tocilizumab was administered to 125 patients: 65 received IV and 60 received SC therapy. At day seven, 52% of the patients in the IV group demonstrated improvement in respiratory parameters,
compared to 28% in the SC group (P = 0.01). Mortality rates at days seven and 28 were 15% and 37%, respectively in the IV group and 17% and 50%, respectively in the SC group (P = NS). In-hospital mortality rate was 38% for the IV group versus 57% for the SC
group (P = 0.04). More than 90% of patients in each group received corticosteroids, however significantly more patients in received convalescent plasma in the IV group. |
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Topical lignocaine anaesthesia for oropharyngeal sampling for COVID-19 |
Kanodia, A, Srigyan, et al |
Eur Arch Otorhinolaryngol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Adult patients testing positive on the RT-PCR COVID-19 test were sampled again within 48 h after administering topical
oropharyngeal anaesthesia. Patients were asked to rate their discomfort on a visual analog scale (VAS) for both sample A and B. Forty patients were included in the study. Twenty-nine patients (72.5%) reported the procedure to be more comfortable post-lignocaine
application. Median (IQR) discomfort on VAS decreased from 7 (1) to 5 (2) after lignocaine use, which was statistically significant (p < 0.05). Mean Ct value for sample A was 17.21 ± 5.25 and for sample B was 18.44 ± 4.8 (p > 0.05), indicating a non-significant
effect of lignocaine on SARS-CoV-2 concentration in the sample. |
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Clinical effects of probiotics in ordinary-type COVID-19 patients with diarrhea |
Ke, E, Zhang, et al |
World Chinese Journal of Digestology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
We evaluate the role of probiotics in the treatment of COVID-19 patients with diarrhea. Of the 800 patients with common
COIVD-19, 90 patients had diarrhea, with an incidence of 11.25%; and probiotics have obvious effects on alleviating patients' abdominal distension, nausea, vomiting and other gastrointestinal symptoms. |
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Kenward, C, Pratt, et al |
BMJ Open |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
We use Population Health Management (PHM) methods to identify and characterise individuals at high-risk of severe COVID-19
for which shielding is required, for the purposes of managing ongoing health needs and mitigating potential shielding-induced harm. PHM methods are useful in characterising the needs of individuals requiring shielding. Segmentation of the high-risk population
identified groups with distinct characteristics that may benefit from a more tailored response from health and care providers and policy-makers. |
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Khan, H, Chowdhury, et al |
Diabetes Res Clin Pract |
Clinical data| Données cliniques Public Health response| Interventions de santé publique |
We aimed to survey the experiences of patients with Type 2 diabetes (T2D) during Ramadan 2020. COVID-19 had an impact
on people with diabetes and their fasting intentions during Ramadan 2020. Most people who were advised not to fast did not fast; there were few adverse outcomes from fasting. COVID-19 was not more common amongst people who fasted. |
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The impact of COVID-19 pandemic on stock markets: An empirical analysis of world major stock
indices |
Khan, K, Zhao, et al |
Journal of Asian Finance, Economics and Business |
Economics | Économie |
This study aims to investigate the impact of COVID-19 pandemic on the stock markets of sixteen countries. The results
reveal that investors in these countries do not react to the media news of COVID-19 at the early stage of the pandemic. However, once the human-to-human transmissibility had been confirmed, all of the stock market indices negatively reacted to the news in
the short- and long-event window. |
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Khasawneh, L, Al-Omar, et al |
Systematic Reviews in Pharmacy |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The study amis to determine the effect of abnormal BMI in patients with coronavirus disease (COVID-19) on their disease
outcomes. There is a correlation between BMI and COVID-19 outcomes, represented through moderate and severe obese patients were suffered from COVID-19 symptoms for longer duration than others. |
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Kim, I, Lee, et al |
Osong Public Health and Research Perspectives |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study aimed to observe the initial trend of imported COVID-19 cases in South Korea since the beginning of the
outbreak. Streamlined processes of detection, subsequent testing, isolation, and treatment by public health authority, was key in minimizing the risk of secondary transmission. |
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Kinoshita, R, Anzai, et al |
J Clin Med |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
The present study assesses the feasibility of containing COVID-19 by computing the probability of a major epidemic.
We show that if there is a substantial number of asymptomatic transmissions, cutting chains of transmission by means of contact tracing and case isolation would be very challenging without additional interventions, and in particular, untraced cases contribute
to lowering the feasibility of containment. |
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Kithiia, J, Wanyonyi, et al |
Data Brief |
Public Health response| Interventions de santé publique Economics | Économie |
This paper provides preliminary data on the socio-economic impacts of Covid-19 in the coastal city of Mombasa, Kenya,
at the time of government-imposed curfews and cessation of movement. We conducted online surveys for two weeks during the restrictions period. |
|
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Performance of Targeted Library Preparation Solutions for SARS-CoV-2 Whole Genome Analysis |
Klempt, P, Brož, et al |
Diagnostics (Basel) |
Coronavirology| Coronavirologie |
Here we report on the comparison of three commercially available NGS library preparation kits. We discuss advantages
and limitations from the perspective of required input sample quality and data quality for advanced SARS-CoV-2 genome analysis. |
|
Koba, H, Yoneda, et al |
Clinical Case Reports |
Clinical data| Données cliniques |
Three COVID‐19 patients who were received lopinavir/ritonavir plus favipiravir got to improved without any severe adverse
events. Two patients harboring high fever, severe pneumonia and respiratory failure obtained dramatic improvement. |
|
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Kraft, M, Pellino, et al |
Surgeon |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We assess the epidemiology and features of de novo surgical diseases in patients admitted with COVID-19, and their
impact on patients and healthcare system. Incidence of de-novo surgical diseases is low in COVID-19, but it is associated with significant morbidity and mortality. |
|
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The role of Frailty on Adverse Outcomes Among Older Patients with COVID-19 |
Kundi, H, Çetin, et al |
J Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques Public Health Priorities|
Priorités de santé publique |
This was a nationwide cohort study conducted at all hospitals in Turkey. All COVID-19 hospitalized patients (≥ 65 years)
were included. Patients who were alive and not discharged up to July 20, 2020, were excluded. Between March 11, 2020, and June 22, 2020, a total of 18,234 COVID-19 patients from all of 81 provinces of Turkey were included. A frailty-based tailored management
of the older population may provide a more accurate risk categorization for both therapeutic and preventive strategies. |
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Awareness and prevention of COVID-19 infection among rural populations |
Kushali, R, Geetha, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
Risk of spreading the virus is heightened in rural areas. Reasons for high chances in such areas are due to a number
of factors, limited supply of clean water and limited availability of food. Low level of nutrients, ill-equipped and insufficient public health centres and district hospitals. The survey was distributed online to around 100 participants of various rural areas
of Tamil Nadu. The study concludes that there is awareness of COVID and it’s prevention among the people of the rural areas. |
|
#VALUE! |
Kushlaf, H |
Muscle Nerve |
Clinical data| Données cliniques |
We report the case of a patient with muscle‐specific kinase (MuSK) antibody–positive myasthenia gravis (MG) who developed
coronavirus disease‐2019 (COVID‐19). We report the clinical course of COVID‐19 focusing on the MG postintervention status in this patient. |
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32910979; Performance of an automated chemiluminescence SARS-CoV-2 IG-G assay |
Lau, CS, Oh, et al |
Clinica Chimica Acta |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We describe our evaluation of the Abbott SARS-CoV-2 IgG assay on the Architect immunoassay analyser. The assay specificity
was 99.8% (n = 980) and sensitivity was 45.9–96.7% (n = 279). When tested ≥ 14 days post-positive RT-PCR (POS), the PPV/NPV was 96.4%/99.8%. The Abbott SARS-CoV-2 IgG assay shows excellent performance in patients ≥ 14 days POS. |
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Early Identification of IgA Anti-SARSCoV-2 in Milk of Mother With COVID-19 Infection |
Lebrão, CW, Cruz, et al |
J Hum Lact |
Clinical data| Données cliniques |
A 32-year-old pregnant woman, gestational age 37 and 3/7 weeks, was admitted with a flu-like syndrome caused by COVID-19.
The female newborn was appropriate for gestational age. Anti-SARS-CoV-2 Immunoglobulin A was detected in the two samples of breastmilk evaluated, whose values were 2.5 and 1.9, respectively. No anti-SARSCoV-2 immunoglobulin G was detected. The exclusively-breastfed
infant remained well through 45 days of age. |
|
Early experiences of COVID-19 infected, middle-aged patients |
Lee, J, Yam, et al |
J Med Imaging Radiat Oncol |
Clinical data| Données cliniques |
This case report describes our early radiological experiences of middle-aged patients with COVID-19 at Westmead Hospital,
Sydney. We found limited relationship between initial CT imaging appearances and progression to severe disease. The most effective use of imaging in COVID-19 is yet to be determined. |
|
Lee, JE, Mohanty, et al |
J Neurointerv Surg |
Healthcare Response | Réponse des soins de santé |
To assess the impact of COVID-19 on neurosurgical, stroke neurology, and neurointerventional academic productivity.
Manuscript submission was used as a surrogate metric for academic productivity. There was a momentous increase in the number of original submissions for the year 2020, and its effects were uniformly experienced across all of our represented journals. |
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Lee, JH, Kim, et al |
Menopause |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We evaluate the effect of female sex hormones on the clinical outcomes of coronavirus disease 2019 patients using national
claims data. In the multivariable Cox analysis, older age and underlying comorbidities, but not sex, were independent risk factors for mortality. Hormone therapy was not significantly associated with clinical outcomes. |
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COVID-19 Trends Among School-Aged Children - United States, March 1-September 19, 2020 |
Leeb, RT, Price, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Public Health Priorities| Priorités de santé publique |
Since March, 277,285 COVID-19 cases in US children have been reported. COVID-19 incidence among adolescents aged 12–17
years was approximately twice that in children aged 5–11 years. Underlying conditions were more common among school-aged children with severe outcomes related to COVID-19. These results can provide a baseline for monitoring trends and evaluating mitigation
strategies. |
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Evaluation of anxiety levels amidst COVID-19 pandemic among Chennai population |
Lekha, Hannah, R |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
Self-administered questionnaires were designed based on knowledge attitude, and practice among Chennai population.
The knowledge and awareness of COVID 19 are high in the Chennai population. Along with an increase in the anxiety level in the context of COVID 19. The results show the need for social support to alleviate stress and improve mental health. |
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Model Calculations of Aerosol Transmission and Infection Risk of COVID-19
in Indoor Environments |
Lelieveld, Jos, Helleis, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Transmission |
The role of aerosolized SARS-CoV-2 viruses in airborne transmission of COVID-19 is debated. The transmitting aerosol
particles are generated through the breathing and vocalization by infectious subjects. Some authors state that this represents the dominant route of spreading, while others dismiss the option. Public health organizations generally categorize it as a secondary
transmission pathway. Here we present a simple, easy-to-use spreadsheet model to estimate the infection risk for different indoor environments, constrained by published data on human aerosol emissions, SARS-CoV-2 viral loads, infective dose and other parameters.
We evaluate typical indoor settings such as an office, a classroom, a choir practice room and reception/party environments. These are examples, and the reader is invited to use the algorithm for alternative situations and assumptions. Our results suggest that
aerosols from highly infective subjects can effectively transmit COVID-19 in indoor environments. This "highly infective" category represents about twenty percent of the patients tested positive for SARS-CoV-2. We find that "super infective" subjects, representing
the top five to ten percent of positive-tested ones, plus an unknown fraction of less, but still highly infective, high aerosol-emitting subjects, may cause COVID-19 clusters (>10 infections), e.g. in classrooms, during choir singing and at receptions. The
highly infective ones also risk causing such events at parties, for example. In general, active room ventilation and the ubiquitous wearing of face masks (i.e. by all subjects) may reduce the individual infection risk by a factor of five to ten, similar to
high-volume HEPA air filtering. The most effective mitigation measure studied is the use of high-quality masks, which can drastically reduce the indoor infection risk through aerosols.Competing Interest StatementThe authors have declared no competing interest.Clinical
TrialThis study used published data in the analysis.Funding StatementMax Planck Society.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details
of the IRB/oversight body that provided approval or exemption for the research described are given below:Not applicable.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that
all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID
is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded
the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data used in the analysis are provided in the manuscript and supplementary materials. |
|
Organization of extracorporeal membrane oxygenation services for COVID-19 |
Leow, L, Papadimas, et al |
Asian Cardiovasc Thorac Ann |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We share our institution’s experience in organizing extracorporeal membrane oxygenation services in Singapore during
the COVID-19 pandemic. Overall, we found extracorporeal membrane oxygenation is an option for COVID-19 patients but preparation must be taken to prepare the extracorporeal membrane oxygenation teams to deal with this pandemic and future challenges. |
|
Lexmond, AxelS, Nouwen, et al |
medRxiv |
Epidemiology| Épidémiologie |
COVID 19 cases have peaked and declined rapidly in many low and middle income countries (LMICs) in recent months, in
some cases after control measures were relaxed. For 11 such countries, the hypothesis that these countries have reached herd immunity warrants serious consideration. The Reed Frost model, perhaps the simplest description for the evolution of cases in an epidemic,
with only a few constant parameters, fits the observed case data remarkably well, and yields parameter values that are reasonable. The model results give infection rates of 45% and 79%, above the herd immunity thresholds for each country (under current social
distancing conditions). Reproduction numbers range between 1.4 and 2.0, indicating that epidemic curves were flattened but not suppressed. Between 0.05% and 2.86% of cases have been detected according to the estimates; values which are consistent with findings
from serological and T-cell immunity studies. Overall infection fatality ratios for two of three countries studied are lower than expected from reported infection fatality ratios by age (which are based on studies of several high income countries). COVID 19
may have lower age specific fatality risks in some countries, due to differences in immune-response, prior exposure to coronaviruses, disease characteristics or other factors. We find that the herd immunity hypothesis would not have fit the evolution of reported
cases in several European countries, even just after the initial peaks; and subsequent resurgences of cases obviously prove that those countries have infection rates well below herd immunity levels. Our hypothesis that the 11 countries we studied have reached
herd immunity should now be tested further, through serological and T cell immunity studies.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo funding was received to support this workAuthor DeclarationsI confirm
all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:We used only
publicly available, anonymised data and applied only statistical analysis on this data.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other
prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective
study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research
reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data used is publicly available data (as published by WHO). Relevant sources are included in footnotes where applicable. All equations and methods used in this
article are described in the supplementary material which we submit at the same time as a separate publication. https://covid19.who.int/?gclid=Cj0KCQjwqrb7BRDlARIsACwGad70vhvBpGrU5OzlW0YlQIWvqdC5JdvmP6jSYm14cVkMyRsMnQvtILIaAhwcEALw_wcB |
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|
Li, H, Zhao, et al |
Emerg Microbes Infect |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we used a replication-competent recombinant VSVs (rVSVs) encoding the spike (S) protein of SARS-CoV-2 in place
of the original G glycoprotein (rVSV-eGFP-SARS-CoV-2) to develop a high-throughput entry assay for SARS-CoV-2. The neutralizing titers of antibodies and sera measured by rVSV-eGFP-SARS-CoV-2 were highly correlated with those measured by wild-type viruses or
pseudoviruses. Therefore, this is a safe and convenient screening tool for SARS-CoV-2, and it may promote the development of COVID-19 vaccines and therapeutics. |
|
|
Li, J, Gao, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
This paper examined the relationship between coaches and youth athletes in China by comparing data collected before
and after the lockdown. A total of 221 youth athletes aged 13–19 years in one professional football school completed coach-athlete relationship questionnaires. The results of the Mann-Whitney U test showed that mean value of the three dimensions of the coach-athlete
relationship (closeness, commitment, and complementarity) increased after the COVID-19 lockdown. |
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|
The application value of low-dose CT scan in pregnant women with COVID-19 |
Li, L, Wang, et al |
Chinese Journal of Radiological Medicine and Protection |
Clinical data| Données cliniques |
We explore the application value of low-dose CT in pregnancy complicated with novel coronavirus pneumonia. Among the
12 pregnant patients with new coronary pneumonia, 8 had cough, 4 had fever, 2 had chest tightness, and 1 each had dyspnea and diarrhea. The subjective CT image quality scores of all patients were 3 to 4 points, with an average of 3.46 points, which fully met
the clinical diagnosis requirements. The application of low-dose CT scan in pregnancy complicated with new coronary pneumonia is completely feasible. |
|
Li, Meng-Hao, Haynes, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
By using county-level mobility data as a measure of a community’s voluntary compliance with social distancing policies,
this study found that counties who received strong state social distancing policy directives and who had a high pro-social character showed lower mobility (better social distancing) after states reopened from shelter-in-place orders. Counties that experienced
a longer duration of shelter-in-place orders showed higher mobility (less social distancing). |
|
|
Li, T |
EPL |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
A general-purpose simulator for the spread of epidemics in China is built. At each city, an open-system SEIR model
tracks the local spread of the disease, with population in- and out-flow exchanging with the overlying transportation network. The model accounts for 1) different transmissivities on different transportation media, 2) the transit of inbound flow, 3) cross-infection
in public transportation due to path overlap, and that 4) infected population not entering public transportation, 5) recovered population not subject to repeated infections. The framework is robust and reliable, and best-fit inversion results match public
datasets. |
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|
Comparisons of Pooling Matrices for Pooled Testing of COVID-19 |
Lin, Yi-Jheng, Yu, et al |
ArXiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Group testing approach for COVID-19 has received a lot of interest lately. In this paper, we propose a new family of
pooling matrices from packing the pencil of lines (PPoL) in a finite projective plane. By conducting extensive simulations for a range of prevalence rates up to 5%, our numerical results show that there is no pooling matrix with the lowest relative cost in
the whole range of the prevalence rates. To optimize the performance, one should choose the right pooling matrix, depending on the prevalence rate. |
|
Liu, A, Zhang, et al |
J Pathol |
Clinical data| Données cliniques Animal model | Modèle animal |
Here, we explored the location and expression of ACE2, and its correlation with gender, age and cigarette smoke (CS),
in a CS-exposed mouse model and 224 non-malignant lung tissues (125 non-smokers, 81 current smokers and 18 ex-smokers) by immunohistochemistry. Our results indicate that smoking-induced ACE2 overexpression in the apical surface of bronchial epithelial cells
provide a route by which SARS-CoV-2 can enter host cells. |
|
|
Liu, C, Mao, et al |
RSC Advances |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In this article, we present the principle and procedure of developing a colloidal gold immunochromatographic assay
(GICA) for rapid detection of COVID-19-specific antibodies. The detection kit can be used to detect immunoglobulin M (IgM) and IgG of COVID-19 in human blood samples within 15 minutes, and to identify different stages of viral infection. Based on analysis
from 375 samples, we calculated that overall sensitivity and specificity of the assay were 95.85% and 97.47%, respectively. |
|
|
Liu, Tianyuan, Balzano-Nogueira, et al |
bioRxiv |
Clinical data| Données cliniques |
We created DeCovid, an R shiny app that combines gene expression data of different human tissue from the Genotype-Tissue
Expression (GTEx) project and the COVID-19 Disease Map gene collection to explore basal gene expression differences across healthy demographic groups. We used this app to study differential gene expression between men and women for COVID-19 associated genes.
We identified that healthy women present higher levels in the expression of interferon genes and the JAK-STAT pathway leading to cell survival. |
|
|
Liu, Y, Wei, et al |
|
Therapeutics| Thérapeutique |
The objectives of this study were to screen out the main active ingredients of Shufeng Jiedu Granules based on network
pharmacology, predict the potential targets and signaling pathways of Shufeng Jiedu Granules for the treatment of Novel Coronavirus Pneumonia (NCP), and explore its mechanism. The active compounds in Shufeng Jiedu granules can treat the Novel Coronavirus
Pneumonia by multiple targets and multiple pathways. |
|
|
Loh, PS, Chaw, et al |
Anesth Analg |
Healthcare Response | Réponse des soins de santé |
Here, we describe the preparation in an anesthetic department using simulation-based training over two weeks, as the
number of COVID-19 cases rose rapidly. Three areas of priority were identified - staff safety, patient movement and possible clinical scenarios based on simulation principles in healthcare education. Simulation-based training was a useful preparation tool
for small institutions with limited time, resources, and manpower in developing nations. |
|
|
Impact of meteorological conditions and air pollution on COVID-19 pandemic transmission in Italy |
Lolli, S, Chen, et al |
Sci Rep |
Epidemiology| Épidémiologie Transmission |
In this study, we quantitatively assessed how the meteorological and air quality parameters are correlated to the COVID-19
transmission in two large metropolitan areas in Northern Italy as Milan and Florence and in the autonomous province of Trento. Our main findings highlight that COVID-19 pandemic transmission prefers dry and cool environmental conditions, as well as polluted
air. |
|
López-Abente, J, Valor-Suarez, et al |
Epidemiol Infect |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this study, the epidemic in Spain has been simulated by ICMs (Stochastic Individual Contact Models). The simulated
scenarios were: 1) Non-intervention, 2) Temporary locking/confinement, 3) Temporary locking /confinement plus mass determination of infectious status with self-isolation in the event of being infective. Without any intervention, 95% of the population would
become infected, 2% dying in less than 3 months. In “Lockdown 1” there is an important rebound that multiplies by 2 the impact of the first wave. The intervention on the quarantine rate facilitated by the massive execution of the diagnostic test would avoid
this second wave. |
|
|
López-Bueno, R, López-Sánchez, et al |
Frontiers in Pediatrics |
Public Health response| Interventions de santé publique |
Our study aimed to investigate the impact that the Covid-19 confinement has on health-related behaviors among Spanish
children and adolescents.study suggests that Covid-19 confinement reduced physical activity levels, increased both screen exposure and sleep time, and reduced fruit and vegetable consumption. |
|
|
Effective treatment of SARS-CoV-2-infected rhesus macaques by attenuating inflammation |
Lu, S, Zhao, et al |
Cell Res |
Clinical data| Données cliniques Therapeutics| Thérapeutique Animal model | Modèle
animal |
Recently, we developed a β-galactosidase (β-gal)-activated prodrug SSK1 that is able to effectively target macrophages,
in which the expression of β-gal has been reported to be a physiological response to immune stimuli. In this study, we investigated the therapeutic effects of SSK1 in SARS-CoV-2-infected nonhuman primate model. SSK1 efficiently mitigated clinical symptoms
and pathologically reduced SARS-CoV-2-infected pneumonia, and there was a reduction in macrophage infiltration in the lungs of SSK1-treated animals. |
|
Lui, GC, Yip, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to compare the case fatality ratio (CFR) and its predictors of COVID-19 and SARS patients using a territory-wide
cohort in Hong Kong. The CFR of COVID-19 was 0.4%. Age, diabetes and laboratory parameters (high lactate dehydrogenase, high C-reactive protein, and low platelet count) were associated with worse outcomes, whereas antiviral treatments were not. |
|
|
Retrospective analysis of digestive system manifestations in patients with coronavirus disease 2019 |
Lv, F, Ding, et al |
World Chinese Journal of Digestology |
Clinical data| Données cliniques |
The objective of this study was to explore the digestive system manifestations of 350 patients with COVID-19 hospitalized
at our hospital in Wuhan, to provide reference for the diagnosis and treatment of COVID-19. Hospitalized COVID-19 patients may show some digestive system symptoms, with diarrhea and vomiting being most common. Compared with non-critically ill patients, the
incidence of digestive system symptoms is generally similar to that of non-critically ill patients, but the incidence and degree of abnormal liver function indexes are higher in critically ill patients. |
|
Characteristic of 523 COVID-19 in Henan Province and a Death Prediction Model |
Ma, X, Li, et al |
Frontiers in Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Clinical
data| Données cliniques |
This study was conducted to delineate the clinical characteristics of patients with COVID-19 in China of different
degree and establish a death prediction model. Age was the leading risk factors for poor prognosis. Mixed model constructed with combination of age, demographics, symptoms, and laboratory findings at admission had the best performance (p = 0.021) with a generalized
AUC of 0.9852 |
|
MacIntyre, CR, Dung, et al |
BMJ Open |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
In a previous randomised controlled trial (RCT) in hospital healthcare workers (HCWs), cloth masks resulted in a higher
risk of respiratory infections compared with medical masks. The objective of this study was to do a post hoc analysis of unpublished data on mask washing and mask contamination from the original RCT to further understand poor performance of the two-layered
cotton cloth mask used by HCWs in that RCT. The risk of seasonal respiratory viruses was more than double among HCW self-washing their masks compared with the hospital laundry. Cloth masks washed in the hospital laundry were as protective as medical masks. |
|
|
Maddaloni, E, D'Onofrio, et al |
Cardiovasc Diabetol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated features and Covid-19 outcomes for patients with or without diabetes, and with or without cardiometabolic
multimorbidity. Patients with diabetes hospitalized for Covid-19 present with high-risk features. They are at increased risk of adverse outcomes, likely because diabetes clusters with other cardiometabolic conditions. |
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|
Mafruchati, M |
Systematic Reviews in Pharmacy |
Public Health response| Interventions de santé publique |
This study has an objective to observe the relation between trends of information about dates (the food), the reason
that caused the trends, as well as its benefit to COVID cases in samples of the study. The samples are Indonesia and Saudi Arabia. The inclusive criteria of samples are topic related to dates used on the internet and popularity points of information about
date palm. The result shows that trends are more robust in Saudi than in Indonesia. The relevance point about dates in Saudi reaches 14 while Indonesia is 8.05. |
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|
Eculizumab treatment for renal failure in a pediatric patient with COVID-19 |
Mahajan, R, Lipton, et al |
Journal of nephrology |
Clinical data| Données cliniques |
We present a pediatric case of COVID-19 and renal failure due to thombotic microangiopathy, successfully treated with
eculizumab in New York, USA. |
|
Makaronidis, J, Mok, et al |
PLoS Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
The study aimed to determine the seroprevalence of SARS-CoV-2 antibodies in a community-based population with acute
loss of smell and/or taste and to compare the frequency of COVID-19 associated symptoms in participants with and without SARS-CoV-2 antibodies. It also evaluated whether smell or taste loss are indicative of COVID-19 infection. A total of 77.6% of 567 participants
with acute smell and/or taste loss had SARS-CoV-2 antibodies. New loss of smell was more prevalent in participants with SARS-CoV-2 antibodies, compared with those without antibodies. Seropositivity for SARS-CoV-2 was 3 times more likely in participants with
smell loss compared with those with taste loss. |
|
|
32573711; Platelet gene expression and function in patients with COVID-19 |
Manne, BK, Denorme, et al |
Blood |
Clinical data| Données cliniques |
In this study, we report altered platelet gene expression and functional responses in patients infected with SARS-CoV-2.
RNA sequencing demonstrated distinct changes in the gene-expression profile of circulating platelets of COVID-19 patients. Pathway analysis revealed differential gene-expression changes in pathways associated with protein ubiquitination, antigen presentation,
and mitochondrial dysfunction. Findings demonstrate that SARS-CoV-2 infection is associated with platelet hyperreactivity, which may contribute to COVID-19 pathophysiology. |
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32959803; Schiavonia Hospital response to COVID-19 outbreak: a first single-center experience |
Marcon, E, Scotton, et al |
Annali dell'Istituto Superiore di Sanita |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
On 21 February 2020, Schiavonia Hospital (SH) detected the first 2 cases of COVID-19 in Veneto Region. The aim of this
article is to describe how SH was able to adjust its services coping with the epidemiological stages of the pandemic. The first period, after initial cases' identification, was characterized by the hospital isolation. In the second period the hospital reopened
and it was divided into two completely separated areas, named COVID-19 and COVID-free, to prevent intra-hospital contamination. The last period was characterized by the re-organization of the facility as the largest COVID Hospital in Veneto, catching exclusively
COVID-19 patients from the surrounding areas. On 7 April 2020, 22 out of 695 HCW (3.2%) had a positive nasopharyngeal swab. |
|
Martinot, M, Jary, et al |
Clin Infect Dis |
Clinical data| Données cliniques |
INTRODUCTION: On 21 February 2020, Schiavonia Hospital (SH) detected the first 2 cases of COVID-19 in Veneto Region.
As a result of the underlying concomitant spread of infection, SH had to rearrange the clinical services in terms of structural changes to the building, management of spaces, human resources and supplies, in order to continue providing optimal care to the
patients and staff safety. The aim of this article is to describe how SH was able to adjust its services coping with the epidemiological stages of the pandemic. MATERIAL AND METHODS: Three periods can be identified; in each one the most important organizational
modifications are analyzed (hospital activities, logistical changes, communication, surveillance on HCW). RESULTS: The first period, after initial cases' identification, was characterized by the hospital isolation. In the second period the hospital reopened
and it was divided into two completely separated areas, named COVID-19 and COVID-free, to prevent intra-hospital contamination. The last period was characterized by the re-organization of the facility as the largest COVID Hospital in Veneto, catching exclusively
COVID-19 patients from the surrounding areas. CONCLUSIONS: SH changed its organization three times in less than two months. From the point of view of the Medical Direction of the Hospital the challenges had been many but it allowed to consolidate an organizational
model which could answer to health needs during the emergency situation. |
|
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COVID-19 pneumonia and pulmonary microembolism in a patient with B-thalassemia major |
Marziali, M, Ribersani, et al |
Clinical Case Reports |
Clinical data| Données cliniques |
We describe a case of a 46‐year‐old man with thalassemia with COVID‐19 pneumonia complicated at illness day 17 by severe
plurisegmentary pulmonary microembolism, treated with a combination of drugs and oxygen therapy with C‐PAP. |
|
Awareness about convalescent plasma therapy in managing covid-19 among dental students |
Masilamani, N, Ganapathy, et al |
International Journal of Research in Pharmaceutical Sciences |
Healthcare Response | Réponse des soins de santé |
This survey was performed for assessing the awareness about convalescent plasma therapy in managing COVID-19 amongst
dental students. 9% are aware of Convalescent Plasma therapy. 15% are aware of the mechanism of action of Convalescent Plasma therapy. 15% are aware of the indications of Convalescent Plasma therapy. 13% are aware of the contraindications of Convalescent Plasma
therapy. 11% are aware of the side effects of Convalescent Plasma therapy. |
|
Matos, J, Paparo, et al |
Eur Radiol Exp |
Healthcare Response | Réponse des soins de santé |
We investigated whether the internal gantry components of our computed tomography (CT) scanner contain SARS-CoV-2 ribonucleic
acid (RNA). From 1 to 27 March 2020, we performed 180 examinations of patients with confirmed SARS-CoV-2 infection using a dedicated CT scanner. RT-PCR detected SARS-CoV-2 RNA in the inward airflow filter sample. RT-PCR of remaining gantry samples did not
reveal the presence of SARS-CoV-2 RNA. |
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|
Matsunaga, N, Hayakawa, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study describes the characteristics of COVID-19 patients requiring hospitalization in Japan. The most common comorbidities
were hypertension and diabetes. Overall, 66.9% (1762/2634) of patients were discharged home, while 7.5% (197/2634) died. When compared with existing inpatient studies in other countries, these results demonstrated less comorbidities and a trend towards lower
mortality. |
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McSwain, JR, Bridges, et al |
Perioper Care Oper Room Manag |
Healthcare Response | Réponse des soins de santé |
We aim to highlight our experiences and challenges for preoperative SARS-CoV-2 testing. As of August 2020, we have
been able to achieve an over 90% success rate in preoperative SARS-CoV-2 PCR testing for both outpatient and inpatient procedures. However, there are certain challenges in obtaining high levels of compliance both on individual and institutional levels. |
|
|
Medeiros, Inácio Gomes, Khayat, et al |
bioRxiv |
Coronavirology| Coronavirologie |
In this work, we propose a database of SARS-CoV-2 targets for siRNA approaches. Beyond target sequences, it also displays
more than 170 features, including thermodynamic information, base context, target genes and alignment information of sequences against the human genome, and diverse SARS-CoV-2 strains, to assess whether siRNAs targets bind or not off-target sequences. We hope
that this database helps to speed the development of new target antivirals for SARS-CoV-2, contributing to more rapid and effective responses to the COVID-19 pandemic. |
|
|
Mei, F, Bonifazi, et al |
Chest |
Clinical data| Données cliniques |
Describes the first case of reverse transcriptase-polymerase chain reaction detection of severe acute respiratory syndrome
coronavirus 2 in pleural fluid obtained by means of ultrasound-guided thoracentesis. |
|
|
Headache as a Cardinal Symptom of Coronavirus Disease 2019: A Cross-Sectional Study |
Membrilla, JA, de Lorenzo, et al |
Headache |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Conducted a cross‐sectional study in the emergency department (ED) of a tertiary hospital to establish headaches to
be a a very prevalent COVID‐19 symptom among patients presenting to the ED. Most frequently presenting as holocranial or bifrontal moderate to severe, and pressing quality headache. |
|
Transpulmonary pressures in obese and non-obese COVID-19 ARDS |
Mezidi, M, Daviet, et al |
Ann Intensive Care |
Clinical data| Données cliniques |
Investigated esophageal pressure allowing determination of transpulmonary pressures (PL ) and elastances (EL) during
a decremental positive expiratory pressure (PEEP) trial from 20 to 6 cm H2O in a cohort of COVID-19 ARDS patients (n=15). |
|
Association between Cardiac Troponin I and Mortality in Patients with COVID-19 |
Michela, S, Barbara, et al |
Biomarkers |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Evaluate the role of high sensitivity cardiac troponin I (hs-TnI) in patients with SARS-CoV-2 infection. A significant
difference in hs-TnI concentrations was found between deceased patients (98 patients) vs discharged (425 patients) [36.05 ng/L IQR 16.5-94.9 vs 6.3 ng/L IQR 2.6-13.9, p < 0.001 respectively]. Hs-TnI measurements were independent predictors of mortality at
multivariate analysis adjusted for confounding parameters such as age (HR 1.004 for each 10 point of troponin, 95% CI 1.002-1.006, p < 0.001). |
|
St Andrew's COVID-19 surgery safety (StACS) study: Elective plastic surgery, trauma & burns |
Miranda, BH, Hughes, et al |
Journal of Plastic, Reconstructive and Aesthetic Surgery |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
A prospective cohort study was undertaken in all patients who underwent surgical or non-operative management during
the UK COVID-19 pandemic peak. Demonstrate that even heterogeneous sub-speciality patient groups, who required operative/non-operative management, did not incur an increased COVID-19 risk compared to each other or to control. |
|
Mohanty, S, Lakkireddy, et al |
J Interv Card Electrophysiol |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
Evaluated the efficacy of widespread testing of asymptomatic individuals (n=1670) among electrophysiology (EP) healthcare
workers, patients and caregivers. 64 (3.8%) positive cases were identified, and a significant increase in positivity rate was observed from April to June 2020. EP procedures of positive cases were postponed until negative test results at retesting, positive
staff were re-tested prior to returning to work post 2 weeks of quarantine. Due to suspected exposure testing and contact tracing was conducted among some staff. No new infections were reported in patients within 2 weeks following hospital-stay. |
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Moore, KA, Lucas, et al |
Psychology and Psychotherapy: Theory, Research and Practice |
Public Health response| Interventions de santé publique |
Explored the level of psychological distress people experienced in social isolation associated with COVID-19 control
in Australia, and the factors which might ameliorate or exacerbate psychological distress. A positive attitude towards social isolation introduced by government as a strategy to reduce the transmission of COVID‐19 was predictive of positive coping strategies,
and both attitude and coping predicted reduced psychological distress. Participants’ worries about contagion of COVID‐19, their financial status, and the economic and political impact of the COVID‐19 pandemic predicted increases in their psychological distress.
Social support from family and work colleagues was not significant in reducing worries or psychological distress but it did positively predict engagement in coping. |
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Moss, R, Wood, et al |
Emerg Infect Dis |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
Applied an age risk stratified model to estimate healthcare requirements for COVID-19 patients in the context of broader
public health measures in Australia (e.g. case targeted interventions, expansion of critical care capacity, social distancing, etc). Case isolation and contact quarantine applied at the same level of effective coverage throughout the epidemic was found to
substantially reduce transmission. Increasing the number of ICU beds available to patients with COVID-19 reduces the time over which ICU capacity is anticipated to be exceeded, potentially by more than half. |
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Mukhopadhyay, D, Mussa, et al |
Brain Sciences |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Investigate the microRNAs that regulate the expression of hypothalamic angiotensin-converting enzyme 2 (ACE2) and transmembrane
serine protease 2 (TMPRSS2), essential elements for SARS-CoV-2 cell entry. |
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Mumbu, AJ, Hugo, et al |
J Biol Dyn |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
A mathematical model for studying COVID-19 transmission dynamics in the presence of face mask wearing and hospitalization
services of human population in Tanzania. |
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Munekawa, C, Hosomi, et al |
Endocr J |
Public Health response| Interventions de santé publique |
Investigate the acute effects of the coronavirus disease 2019 (COVID-19) on the lifestyle and metabolic parameters
in patients with type 2 diabetes mellites (n=203). A negative correlation between stress and exercise and a positive correlation between stress and prepared food intake was identified within the study sample. Many patients experienced stress and lifestyle
changes due to the COVID-19 pandemic, and these changes were associated with increased body weight and HbA1c levels. |
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Media system dependency and change in risk perception during
the COVID-19 pandemic |
Muñiz, C |
Tripodos |
Public Health response| Interventions de santé publique |
COVID-19 pandemic risk perception, and the influence of media consumption on a Mexican population's attitude was investigated.
The results present a population with a relatively low risk perception, but moderate dependency on accessing all information linked to the pandemic. This dependency tends to generate an indirect increase in risk perception through the consumption of television,
digital press and Facebook. |
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Hospital mortality in mechanically ventilated COVID-19 patients in Mexico |
Ñamendys-Silva, SA, Gutiérrez-Villaseñor, et al |
Intensive Care Med |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
Describes the sociodemographic characteristics and comorbidities associated with mortality in mechanically ventilated
adults with COVID-19 in Mexico. Overall in-hospital mortality was 73.7% (n = 8861), crude mortality was higher in public healthcare system compared to private healthcare systems. Observed mortality rates were higher than rates among high-income countries such
as the United Kingdom and Germany. |
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Nardone, OM, Rispo, et al |
Therapeutic Advances in Gastroenterology |
Healthcare Response | Réponse des soins de santé |
Dedicated contact center service (CCS) on the reorganization of a high-volume IBD center was found to be effective
in maintaining care continuity during the COVID-19 pandemic. |
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COVID-19 and Ischemic Stroke: Clinical and Neuroimaging Findings |
Naval-Baudin, P, Rodriguez Caamaño, et al |
J Neuroimaging |
Clinical data| Données cliniques |
Analyze clinical and neuroimaging characteristics of patients with ischemic CVA during the pandemic peak in our region,
in order to identify atypical presentations. The COVID‐19 group had more in‐hospital mortality, less proximal arterial occlusion on CT or MR angiography, and lower baseline modified Rankin Scale score. |
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Modelling the transmission dynamics of COVID-19 under limited resources |
Ndii, MZ, Adi, et al |
Communications in Mathematical Biology and Neuroscience |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique Public Health response| Interventions de santé publique |
A compartment-based mathematical model is used to study COVID-19 disease transmission dynamics under limited resources;
the model was validated against data from Bali Province, Indonesia. Model analyses scenarios based on 15%, 35% and 60% budget reductions. |
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Neeraj, Mathew, Jimson, et al |
ArXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Propose a comparative analysis of deep learning models -Attention-Long Short Term Memory (AttentionLSTM) for longterm
forecasting of the COVID-19 outbreak as an alternative to statistical models. |
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SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition |
Nelde, A, Bilich, et al |
Nat Immunol |
Coronavirology| Coronavirologie Immunology | Immunologie |
Identify and characterize multiple dominant and subdominant SARS-CoV-2 HLA class I and HLA-DR peptides as potential
T cell epitopes in COVID-19 convalescent and unexposed individuals. The proposed SARS-CoV-2 T cell epitopes enable identification of heterologous and post-infectious T cell immunity and facilitate development of diagnostic, preventive and therapeutic measures
for COVID-19. |
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Nelson-Sathi, Shijulal, Umasankar, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Use a high fidelity bioinformatics pipeline to analyzed SARS-CoV-2 genomes across the globe. Identify 444 non-synonymous
mutations that cause 49 distinct amino acid substitutions in the receptor binding domains (RBD) at the ACE2 interface exploited by SARS-CoV-2 for endurance. |
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Influence of Prone Positioning on Electrocardiogram in a Patient With COVID-19 |
Nguyen, HH, Trohman, et al |
JAMA Intern Med |
Clinical data| Données cliniques |
A case report detailing the presentation and management of a hospitalized COVID-19 patient requiring intubation and
mechanical ventilation. |
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Nidom, RV, Indrasari, et al |
Systematic Reviews in Pharmacy |
Coronavirology| Coronavirologie Immunology | Immunologie |
Identified the D614G mutation at antibody-dependent enhancement (ADE) sequence in SARS-CoV-2 spike protein; LYQDVNC
in the Wuhan-Hu-1 isolate has changed into LYQGVNC in recent mutated isolates. Authors conclude this mutation might affect immune response activities against the virus, including hindering COVID-19 vaccine development activities. |
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COVID-19 superspreading suggests mitigation by social network modulation |
Nielsen, Bjarke Frost, Sneppen, et al |
medRxiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
A mathematical model is used to show COVID-19 superspreading is drastically reduced by mitigation strategies that reduce
overall personal contact number and social clustering limited to an order of 10 people ("social bubbles"). |
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Nihmath Nisha, S, Francis, et al |
International Journal of Research in Pharmaceutical Sciences |
Healthcare Response | Réponse des soins de santé |
Assess the mental health of South Indian medical students during the COVID-19 pandemic and to see if there is any influence
of gender on mental health. |
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SARS-CoV-2 antibody responses in patients with aggressive haematological
malignancies |
Nions, Jenny, Muir, et al |
medRxiv |
Immunology | Immunologie |
Analyzed longitudinal serum samples of hospitalized patients with aggressive haematological malignancies (PHM) on
systemic anti-cancer treatment collected up to 103 days post COVID-19 symptom onset. The majority of PHM with confirmed SARS-CoV-2 infection seroconverted and developed antibodies to the major SARS-CoV-2 antigens (S1 and N) and produced neutralizing antibody
responses. Observed antibody response dynamics were broadly similar to those within the general population, except for a possible delay to seroconversion. |
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PMC7522604; First Case of COVID-19-Associated Collapsing Glomerulopathy in Sub-Saharan Africa |
Nlandu, YM, Makulo, et al |
Case Rep Nephrol |
Clinical data| Données cliniques |
Report a case of collapsing glomerulopathy revealed by acute kidney injury and a new onset of full blown nephrotic
syndrome in a black Congolese patient coinfected with COVID-19 and malaria |
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32970541; COVID-19 in Nigeria: Knowledge and compliance with preventive measures |
Nnama-Okechukwu, C, Chukwu, et al |
Social Work in Public Health |
Public Health response| Interventions de santé publique |
Explored knowledge of COVID-19 and compliance with preventive measures among community members in Anambra State, Nigeria,
using in-depth interviews. Findings revealed a majority of the survey sample believe the COVID-19 pandemic is more of a hoax than reality. Poor knowledge negatively affected individuals' compliance with preventive measures to curb the spread of coronavirus. |
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Nystad, W, Hjellvik, et al |
Tidsskr Nor Laegeforen |
Epidemiology| Épidémiologie |
Examined selected diseases trends among Norwegian adults hospitalized COVID-19, in comparison to the general population.
Among the COVID-19 hospitalised sample, there were higher proportions of individuals with cardiovascular diseases, cancer, type-2 diabetes, and COPD. Additionally, the proportions of hospitalised patients with asthma, other chronic respiratory disease, cardiovascular
disease, ongoing cancer treatment, complications related to hypertension, obesity or over weight, neurological disorders and cardiac and renal failure was also higher than in the general population. |
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Effect of Weather on COVID-19 Transmission and Mortality in Lagos, Nigeria |
Ogaugwu, C, Mogaji, et al |
Scientifica |
Epidemiology| Épidémiologie Transmission |
Explored the effects of daily temperature and humidity on COVID-19 transmission and mortality in Lagos state, Nigeria.
Results demonstrate atmospheric temperature to have a negative correlation with COVID-19 transmission and cumulative mortality. |
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Accidental diagnosis of COVID-19 pneumonia after 18F FDG PET/CT: a case series |
Olivari, L, Riccardi, et al |
Clinical and Translational Imaging |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Suspicious accidental COVID-19 findings in Nuclear Medicine Department need to be reported and appropriately evaluated
to implement proper supportive treatment and infection control measures, as even asymptomatic patients may show abnormalities in chest computer tomography (CT) or chest X-Ray imaging performed for other clinical reasons. |
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Analytic numeric solution of coronavirus (Covid−19) pandemic model in fractional-order |
Owoyemi, AE, Sulaiman, et al |
Communications in Mathematical Biology and Neuroscience |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, we consider the coronavirus (COVID-19) pandemic model. The fractional ordinary differential equations
were defined in the sense of the Caputo derivative. Adams-type predictor-corrector method with α
∈ 0,1] is employed to compute an approximation to the solution
of the model of fractional order. The obtained results are compared with the results by Atangana Baleanu derivative method. Basic reproduction number, R0, affects the model behaviour. We used R0 to establish the stability and existence conditions at the equilibrium
points. The results obtained show that the method is highly applicable and also an efficient approach for solving fractional ordinary differential equations of such order. © 2020 the author(s). |
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Özmete, E, Pak, et al |
Social Work in Public Health |
Public Health response| Interventions de santé publique |
This study aimed to define the relationship between the state/trait anxiety levels and perceived social support in
the COVID-19 pandemic as a global crisis and stressor. r The main hypothesis was that perceived social support would negatively affect the levels of anxiety. A cross-sectional community-based study was carried out using the relational screening model. The
data was collected between March 20 and April 15, 2020, by using an online survey (N = 630). Anxiety levels of individuals, particularly the state anxiety were high during the pandemic. Also, perceived social support and state/trait anxiety levels were analyzed
for various variable categories. Anxiety levels decreased significantly when perceived social support increased. |
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32969235; Neuropsychological and Functional Impact of COVID-19 on Mild Cognitive Impairment |
Padala, KP, Parkes, et al |
American Journal of Alzheimer's Disease and Other Dementias |
Clinical data| Données cliniques |
We present a case report to showcase that behavioral, cognitive, and functional decline may be associated with COVID-19
stay-home guidance among older adults with pre-existent cognitive impairment. In a functionally independent and physically active older adult with Mild Cognitive Impairment, there was worsening in depression and anxiety symptoms associated with the restrictions
of COVID-19. Functional decline was also noted as assessed by Instrumental Activities of Daily Living. We discuss solutions to mitigate the effects of COVID-19 restrictions in this vulnerable population. |
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Pandey, U, Corbett, et al |
Journal of Obstetrics and Gynecology of India |
Healthcare Response | Réponse des soins de santé |
This study was undertaken to assess the psychological effects of this pandemic on the mental health of medical students
and trainees. An online questionnaire was designed to capture information on the participant’s anxieties related to the pandemic and included a validated tool for the assessment of anxiety and depression symptoms (GAD-7 and PHQ-9, respectively). Females had
significantly higher median anxiety (5 v 2, p < 0.002) and depression scores (5 v 3, p = 0.025) than male participants. Female students/junior doctors showed higher anxiety and depression scores than males. |
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Pang, JHQ, Tang, et al |
Annals of Vascular Surgery |
Clinical data| Données cliniques |
Background: There is increasing evidence supporting coronavirus disease 2019 (COVID-19)-related coagulopathy. In the
available literature, only 2 cases of superior mesenteric vein thrombosis have been described. Methods: We present a peculiar case of high-grade small bowel obstruction in a patient with COVID-19 infection. Results: Exploratory laparotomy revealed a congenital
adhesion band with associated focal bowel ischemia contributed by superior mesenteric vein thrombosis and positive lupus anticoagulant. Conclusions: It is important to consider the rare differential of mesenteric vein thrombosis and its related sequelae of
mesenteric ischemia in a patient with COVID-19 who presents with abdominal pain. © 2020 Elsevier Inc. |
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Impact of COVID-19 outbreak in an Italian cohort of patients with systemic sclerosis |
Papa, ND, Sambataro, et al |
Therapeutic Advances in Musculoskeletal Disease |
Epidemiology| Épidémiologie |
The present survey is aimed at knowing the impact of COVID-19 in a cohort of patients with systemic sclerosis (SSc).
Telephone interviews were carried out during the COVID-19 outbreak in patients with SSc followed in a Rheumatic Disease Unit in Italy. A total number of 526 patients with SSc were contacted and interviewed. Of them, 270 and 256 had limited cutaneous and diffuse
cutaneous SSc, respectively. Interstitial lung disease (ILD) was present in 45% of patients and most of them (68.2%) were treated with immunosuppressive therapy. Only two patients were hospitalized for COVID-19-related pneumonia, and one of them died despite
invasive ventilator support. Despite the large prevalence of ILD and immunosuppressive therapies, which can be considered risk factors for the occurrence and severity of incidental viral infections, the impact of COVID-19, in terms of mortality rate and morbidity,
does not appear particularly severe in this large cohort of patients with SSc. |
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Papa, V, Maniou, et al |
Tripodos |
Public Health response| Interventions de santé publique |
The aim of this study is to assess dominant narratives generated through users' reactions towards news content posted
on Facebook so as to examine the role of Facebook during the global crisis of COVID-19. Drawing from different aspects of crisis communication theory and audience-centered studies, this work seeks to investigate the constructed meanings related to this crisis
and interpret users' understanding of news content posted on social networks. Content analysis is employed as a means to evaluate Facebook's potential in (re)defining users' narratives regarding issues related to COVID-19. The first narrative reveals that
a high personalization of user’s news stories through sarcasm and irony is favored over knowledge and information around the pandemic. The second category refers to the discursive meaning constructed around a sentiment of raised awareness related to the impact
of COVID-19, which is clearly marked as a consistent and uniform narrative demonstrating a heterogeneity among users’ discourses. The third category emerging from the analysis is centered on emotions, which often take the form of a unifying, discursive element. |
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MAIT cell activation and dynamics associated with COVID-19 disease severity |
Parrot, T, Gorin, et al |
Sci Immunol |
Clinical data| Données cliniques Immunology | Immunologie |
Here, we investigated the Mucosa-associated invariant T (MAIT) cell compartment in COVID-19 patients with moderate
and severe disease, as well as in convalescence. We show profound and preferential decline in MAIT cells in the circulation of patients with active disease paired with strong activation. Furthermore, transcriptomic analyses indicated significant MAIT cell
enrichment and pro-inflammatory IL-17A bias in the airways. Unsupervised analysis identified MAIT cell CD69high and CXCR3low immunotypes associated with poor clinical outcome. MAIT cell levels normalized in the convalescent phase, consistent with dynamic recruitment
to the tissues and later release back into the circulation when disease is resolved. These findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis. |
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COVID-19 and immunological dysregulation: can autoantibodies be useful? |
Pascolini, S, Vannini, et al |
Clin Transl Sci |
Clinical data| Données cliniques Immunology | Immunologie |
We analyzed the presence and role of autoantibodies in patients with COVID-19-associated pneumonia. We prospectively
studied 33 consecutive patients with COVID-19, 31 (94%) of whom had interstitial pneumonia, and 25 age- and sex-matched patients with fever and/or pneumonia with etiologies other than COVID-19 as the pathological control group. All patients were tested for
the presence of antinuclear antibodies (ANAs), anti-antiphospholipid antibodies (APLs), and anti-cytoplasmic neutrophil antibodies (ANCAs). Fifteen of 33 (45%) patients tested positive for at least one autoantibody, including 11 who tested positive for ANAs
(33%), 8 who tested positive for anti-cardiolipin antibodies (IgG and/or IgM) (24%), and 3 who tested positive for anti-β2-glycoprotein antibodies (IgG and/or IgM) (9%). Patients with poor prognosis (death due to COVID-19 complications) had a significantly
higher respiratory rate at admission (23 breaths per minute vs. 17 breaths per minute; p = 0.03) and a higher frequency of autoantibodies (86% vs. 27%; p = 0.008). In conclusion, autoantibodies are frequently detected in patients with COVID-19 possibly reflecting
a pathogenetic role of immune dysregulation. |
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Patel, B, Eskander, et al |
Journal of endodontics |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to evaluate the success of palliative care on endodontic emergencies during the COVID-19
pandemic and to evaluate the stability of teeth with long-term Ca(OH)2 placement because of delays in treatment completion. Patients presenting for endodontic emergencies during COVID-19 Shelter-in-Place orders received palliative care, including pharmacologic
therapy and/or non–aerosol-generating procedural interventions. Twenty-one patients presented with endodontic emergencies in 25 teeth during statewide shutdown. At a follow-up rate of 96%, 83% of endodontic emergencies required no further treatment or intervention
after palliative care. Thirty-one teeth had received partial or full root canal debridement before statewide shutdown. Mean time to complete treatment was 13 weeks. At a recall rate of 100%, 77% of teeth did not experience any adverse events due to delays
in treatment completion. Palliative care for management of endodontic emergencies is a successful option when aerosol-generating procedures are restricted. This treatment approach may be considered in an effort to reduce risk of transmission of COVID-19 infection
during subsequent shutdowns. |
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Payne, A, Rahman, et al |
Journal of Surgical Education |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to evaluate the impact of redeployment of surgical trainees to intensive care units (ICUs)
during the COVID-19 pandemic–in terms of transferrable technical and nontechnical skills and wellbeing. This was a survey study consisting of a 23-point questionnaire. The study involved surgical trainees that had been redeployed to the (ICU) across all hospitals
in London during the COVID-19 pandemic. The survey was sent to 90 surgical trainees who were between postgraduate years 2 to 4. All respondents spent between 4 and 8 weeks working in ICU. Prior to redeployment, 78% of participants had previous experience of
ICU or an affiliated specialty, and >90% had attended at least 1 educational course with relevance to ICU. There were statistically significant increases in confidence performing central venous cannulation and peripheral arterial catheterisation (p < 0.05).
Redeployment of surgical trainees to ICU led to increased confidence in a number of technical and nontechnical skills. |
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Petrelli, F, Cangelosi, et al |
Diabetes Res Clin Pract |
Healthcare Response | Réponse des soins de santé |
The present pilot study aimed to assess the quality of care provided to patients with micro-infusers in a delicate
phase such as a pandemic lockdown. A mixed-methods approach was used. In the first part, with prior written consent, patients with insulin pumps enrolled voluntarily. In the second part, the focus group discussion (FGD) was carried out with the voluntarily
enrolled participants. The FGD data were organized and analyzed by the thematic areas. The number of patients with afferent insulin pumps at the center was 50 individuals. Among them, 20 patients voluntarily joined the first part of the study by completing
the PACIC questionnaire, which gave an average result of 3.34 (min. 2.2 and max. 4.2). In the second part, the application of the focus group technique demonstrated that technology is decisive in the management of diabetic pathology, not only in the emergency
phase. At the time of public health crises, alternative strategies such as Tele-Nursing or Telemedicine could be crucial for the management of patients with micro-infuser not only in critical moments, such as lockdown, but also in ordinary health management. |
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Pham, H |
Mathematics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In April 2020, the author of this paper presented a model to estimate the number of deaths related to COVID-19, which
assumed that there would be no significant change in the COVID-19 restrictions and guidelines in the coming days. This paper, which presents the evolved version of the previous model published in April, discusses a new explicit mathematical model that considers
the time-dependent effects of various pandemic restrictions and changes related to COVID-19, such as reopening states, social distancing, reopening schools, and face mask mandates in communities, along with a set of selected indicators, including the COVID-19
recovered cases and daily new cases. We analyzed and compared the modeling results to two recent models based on several model selection criteria. The results show the proposed model fit the data significantly better for the United States and worldwide COVID-19
data that were available on 16 August 2020. The results show very encouraging predictability that reflected the time-dependent effects of various pandemic restrictions for the proposed model. The proposed model predicted that the total number of U.S. deaths
could reach 208,375 by 1 October 2020, with a possible range of approximately 199,265 to 217,480 deaths based on data available on 16 August 2020. The model also projected that the death toll could reach 233,840 by 1 November 2020, with a possible range of
220,170 to 247,500 American deaths. The modeling result could serve as a baseline to help decision-makers to create a scientific framework to quantify their guidelines related to COVID-19 affairs |
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Pham, MQ, Vu, et al |
RSC Advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Originating for the first time in Wuhan, China, the outbreak of SARS-CoV-2 has caused a serious global health issue.
An effective treatment for SARS-CoV-2 is still unavailable. Therefore, in this study, we have tried to predict a list of potential inhibitors for SARS-CoV-2 main protease (Mpro) using a combination of molecular docking and fast pulling of ligand (FPL) simulations.
The approaches were initially validated over a set of eleven available inhibitors. Both Autodock Vina and FPL calculations produced consistent results with the experiments with correlation coefficients ofRDock= 0.72 ± 0.14 andRW= −0.76 ± 0.10, respectively.
The combined approaches were then utilized to predict possible inhibitors that were selected from a ZINC15 sub-database for SARS-CoV-2 Mpro. Twenty compounds were suggested to be able to bind well to SARS-CoV-2 Mpro. Among them, five top-leads areperiandrin
V,penimocycline,cis-p-Coumaroylcorosolic acid,glycyrrhizin, anduralsaponin B. The obtained results could probably lead to enhance the COVID-19 therapy. © The Royal Society of Chemistry 2020. |
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Phucharoen, C, Sangkaew, et al |
EClinicalMedicine |
Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions
de santé publique |
This paper explores the specifics of COVID-19 or SARS-CoV-2 transmissions in Phuket, Thailand. High-risk contacts recorded
by Phuket Provincial Public Health Office were analysed using the Probit model to investigate the risk factors for transmission from confirmed COVID-19 cases to their high-risk contacts.15.6% of 1108 high-risk contacts were found to be infected, and they accounted
for 80% of 214 confirmed cases in Phuket till 29th April 2020. Moreover, 10.68% of all high-risk contacts were confirmed to be infected before the quarantine, and 4.55% after the policy was enforced. Results confirmed that the quarantine policy, which mandated
individual isolation in the state provided facilities for all high-risk contacts, diminished contact's chance of infection from the confirmed cases, especially in the epicenter districts. |
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Pieri, M, Ciotti, et al |
Clin Chim Acta |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
BACKGROUND AND AIMS: A novel coronavirus (SARS-CoV-2) was isolated from the respiratory samples of patients with pneumonia
as showed by the sequence analysis of the virus genomes obtained in Wuhan, China. The antibody response to SARS-CoV-2 is not well understood yet, but the availability of sensitive and specific serological assays will be crucial for the early diagnosis of infection,
for epidemiological studies and for defining the presence of neutralizing antibodies in response to a possible vaccine. MATERIALS AND METHODS: We tested and compared the performances of one chemiluminescent immunoassay (CLIA), two enzyme-linked immunosorbent
assay (ELISA) and an electrochemiluminescence immunoassay (ECLIA). RESULTS: The ECLIA serological assay performed best and may be a valid screening method for SARS-COV-2 infection. The IgA detected by the ELISA assay might be a more reliable and stable early
serological marker than IgM. Instead, IgGs, as expected, showed stable level after 10 days from symptoms onset. CONCLUSION: The ECLIA method could be used as screening test, considering both the excellent performance and the cost per single test; while ELISA
assay for IgG and IgA, which are present at a higher level than IgM and last longer, might be used as confirmatory test. |
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Clinical presentation and outcomes of SARS-CoV-2 related encephalitis: the ENCOVID multicentre study |
Pilotto, A, Masciocchi, et al |
J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The ENCOVID multicentre study included patients with encephalitis with full infectious screening, CSF, EEG, MRI data
and confirmed SARS-CoV-2 infection recruited from 13 centres in northern Italy. Twenty-five cases of encephalitis positive for SARS-CoV-2 infection were included. CSF showed hyperproteinorrachia and/or pleocytosis in 68% of cases whereas SARS-CoV-2 RNA by
RT-PCR resulted negative. Based on MRI, cases were classified as ADEM (n=3), limbic encephalitis (LE, n=2), encephalitis with normal imaging (n=13) and encephalitis with MRI alterations (n=7). SARS-CoV-2 infection is associated with a wide spectrum of encephalitis
characterized by different clinical presentation, response to treatment and outcomes. |
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SARS-CoV-2 viral budding and entry can be modeled using virus-like particles |
Plescia, CarolineB, David, et al |
bioRxiv |
Coronavirology| Coronavirologie |
In this work, we assessed the four structural proteins from SARS-CoV-2 for their ability to form virus-like particles
(VLPs) from human cells to form a competent system for BSL-2 studies of SARS-CoV-2. Herein, we provide methods and resources of producing, purifying, fluorescently and APEX2-labeling of SARS-CoV-2 VLPs for the evaluation of mechanisms of viral budding and
entry as well as assessment of drug inhibitors under BSL-2 conditions. |
|
Posarelli, C, Maglionico, et al |
PLoS One |
Healthcare Response | Réponse des soins de santé |
The purpose of this study is to analyze how the pandemic has affected the patient’s accesses to the Ophthalmological
Emergency Department of a tertiary referral center in central-northern Italy, during the lockdown period. The charts of all patients that came to the Emergency Department during the lockdown period (March 10 –May 4, 2020) have been retrospectively collected
and compared with those in the same period of 2019 and the period from 15 January– 9 March 2020. A significant reduction of visits during the lockdown has been observed, compared with those of pre-lockdown period (reduction of 65.4%) and with those of the
same period of 2019 (reduction of 74.3%). Particularly, during the lockdown, minor and not urgency visits decreased whereas the undeferrable urgency ones increased. These pieces of evidence could be explained by the fear of patients to be infected; but also
revealed patients misuse of emergency services. |
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Knowledge and awareness of COVID 19 and its impact on mental health |
Pratheebha, C, Gayatri Devi, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
The main aim of the study is to create awareness and knowledge about COVID – 19 and its impact on the mental health
of the public.The questionnaire was distributed through google docs link to 100 numbers of the study population who were in lockdown irrespective of age. 58% of the total 100 participants’ mental health being affected due to lockdown imposed due to COVID-19.
This COVID 19 has created stress, anxious and nervous situations for 47% of the total participants. Educated people and health professionals are aware of this infection; they take possible preventive measures. |
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Age-related risk of household transmission of COVID-19 in Singapore |
Pung, R, Park, et al |
Influenza Other Respir Viruses |
Epidemiology| Épidémiologie |
Prior to the implementation of social distancing measures, we monitored the close family contacts of the first 400
cases of COVID-19 in Singapore for SARS-CoV-2 infection to determine the risk of infection with age. Adjusting for gender and household size, the risk of COVID-19 infection in household contacts was found to increase with age. |
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Qi, X, Yu, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
This study applied a qualitative approach to investigate the underlying influences on consumers' green food consumption
from the intention generation phase to intention execution phase in the perspectives of purchase intention and the intention-behaviour gap (IBG). Additionally, the impact of the "Coronavirus Disease 2019" (COVID-19) pandemic on consumers' green food purchases
was explored. Research data were derived from semi-structured in-depth interviews with 28 consumers and analyzed using grounded theory. The findings identified factors that influenced intentions and the IBG in the process of consumers' green food purchases.
Specifically, these findings reported that health consciousness, perceived attributes, environmental consciousness, social influence, family structure, and enjoyable shopping experiences were identified as major drivers for generating consumers' green food
purchase intentions. In addition, the results revealed that the COVID-19 crisis increased consumers' green food purchase intentions, whereas the IBG widens as a result of issues of unavailability, price, and panic. |
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Qian, Y, Hanser, et al |
Chinese Sociological Review |
Public Health response| Interventions de santé publique |
Wuhan, the original epicenter of the COVID-19 outbreak, was under strict lockdown for 76 days. We conducted 30 in-depth
interviews to understand Wuhan residents’ lived experiences of lockdown life. We found that despite strong emotions initially, Wuhan residents quickly adapted to life under unprecedented lockdown. We identified three pre-existing structures that facilitated
the effective implementation of the massive lockdown: ready-made containment units offered by urban “gated” housing, a comprehensive grassroots governance network coordinated by shequ (community residence committees), and the ubiquitous WeChat app in Chinese
daily life. We also showed that the pre-existing structures provided space for uncontentious self-organizing, grassroots mobilization, and civic engagement that often dove-tailed with state-mandated measures. This study details the resources Wuhan residents
drew upon to get by during the lockdown, and it illustrates that the feasibility of lockdown measures relies heavily on a society’s structural and institutional conditions. © 2020 Taylor & Francis Group, LLC. |
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Coronavirus Disease-19: Quarantine Framework for Travelers Entering Korea |
Quarantine Management Team, Covid-National Emergency, Response Center |
Osong Public Health and Research Perspectives |
Public health interventions*| Interventions de santé publique |
This study aimed to elucidate the strengthened and flexible quarantine measures in South Korea for people entering
the country, according to the degree of risk, determined by the prevalence of COVID-19 in the country from which the individual departed from. There are currently 869 cases of COVID-19 from overseas as of the 9th April in South Korea, of which 352 cases (40.5%)
were identified at the point of entry into the country, and 517 cases (59.5%) were confirmed during imposed self-quarantine within the community. The results of this study are an outcome of improving the quarantine information systems, and the quarantine and
epidemiological investigation methods at the point of entry at the country’s border and quarantine sites, following the 2015 MERS outbreak in Korea. |
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Model-based Bayesian inference of disease outbreak with invertible neural networks |
Radev, StefanT, Graw, et al |
ArXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Mathematical models in epidemiology strive to describe the dynamics and important characteristics of infectious diseases.
Apart from their scientific merit, these models are often used to inform political decisions and interventional measures during an ongoing outbreak. Since high-fidelity models are often quite complex and analytically intractable, their applicability to real
data depends on powerful estimation algorithms. Moreover, uncertainty quantification in such models is far from trivial, and different types of uncertainty are often confounded. With this work, we introduce a novel coupling between epidemiological models and
specialized neural network architectures. This coupling results in a powerful Bayesian inference framework capable of principled uncertainty quantification and efficient amortized inference once the networks have been trained on simulations from an arbitrarily
complex model. We illustrate the utility of our framework by applying it to real Covid-19 cases from entire Germany and German federal states. |
|
Radha, M, Balamuralitharan, et al |
Advances in Difference Equations |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper deals with a general SEIR model for the coronavirus disease 2019 (COVID-19) with the effect of time delay
proposed. We get the stability theorems for the disease-free equilibrium and provide adequate situations of the COVID-19 transmission dynamics equilibrium of present and absent cases. A Hopf bifurcation parameter τ concerns the effects of time delay and we
demonstrate that the locally asymptotic stability holds for the present equilibrium. The reproduction number is brief in less than or greater than one, and it effectively is controlling the COVID-19 infection outbreak and subsequently reveals insight into
understanding the patterns of the flare-up. We have included eight parameters and the least square method allows us to estimate the initial values for the Indian COVID-19 pandemic from real-life data. It is one of India’s current pandemic models that have
been studied for the time being. This Covid19 SEIR model can apply with or without delay to all country’s current pandemic region, after estimating parameter values from their data. The sensitivity of seven parameters has also been explored. The paper also
examines the impact of immune response time delay and the importance of determining essential parameters such as the transmission rate using sensitivity indices analysis. The numerical experiment is calculated to illustrate the theoretical results. © 2020,
The Author(s). |
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Rehabilitation of Post-ICU Patient after Severe Covid-19 Pneumonia - A Case Report |
Ramalingam, MB, Huang, et al |
Am J Phys Med Rehabil |
Clinical data| Données cliniques |
The recent novel SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus-2) infection resulted in a Covid-19 (Coronavirus
Disease 2019) pandemic that significantly strained healthcare systems globally. The early wave of patients in Singapore with severe pneumonia requiring intensive care units (ICU) are gradually being referred for post-critical illness management with our inpatient
medical rehabilitation unit. There is little available regarding the actual rehabilitation process for patients severely affected by Covid-19. This case report shares experiences and challenges faced during rehabilitation of severe Covid-19 pneumonia and post
intensive care syndrome. It also describes the post-discharge rehabilitation program in a setting of strict nation-wide safe distancing and stay-home policies. |
|
Rawaa Kamel, ABD |
International Journal of Pharmaceutical Research |
Public Health response| Interventions de santé publique |
This cross sectional study consisted of 460 respondents conducted to identify the commitment extent of people to the
standards of prevention measures against corona virus at Al-Nasiriya city at Thi-qar governorate. The study conducted by special questionnaire consist of three parts the first part contain demographic characteristics, second part, concern with implementation
of personal preventive measure, third one was about Sterilization and disinfection of tools and surfaces. The study results reveal that majority of study sample who applied personal preventive measure at age group (21-30), highly statistical association was
found between implementation of personal preventive measures and age at p-value (0.000) also in respect to gender table illustrate that female always applying these measures rather than male, there was significant association at p-value (0.016). From the current
study, we conclude that there is a statistically significant relationship between the application of personal protection measures and gender, as women are more committed to implementing these measures than men. |
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Reilly, SE, Zane, et al |
JMIR Ment Health |
Healthcare Response | Réponse des soins de santé |
This study aims to characterize how mental health practitioners have changed their practices during the pandemic. The
authors hypothesize that mental health practitioners would increase tele-mental health services and that certain provider types would be better able to adapt to tele-mental health than others. 903 practitioners, primarily psychologists/doctoral-level (Psych/DL)
providers, social workers/master's-level (SW/ML) providers, and neuropsychologists employed in academic medical centers or private practices, completed the survey. Differences among providers were examined using Bonferroni-adjusted chi-square tests and one-way
Bonferroni-adjusted analyses of covariance. The majority of the 903 mental health practitioners surveyed shifted their practice to tele-mental health appointments (n=729, 80.82%). Only 2.11% (n=19) reported no COVID-19-related practice adjustments. Two-thirds
(596/888, 67.10%) reported providing additional therapeutic services specifically to treat COVID-19-related concerns. Neuropsychologists were less likely and Psych/DL providers and SW/ML providers were more likely than expected to transition to tele-mental
health (P<.001). Trainees saw fewer patients (P=.01) and worked remotely more than licensed practitioners (P=.03). Despite lower rates of information technology service access (P<.001), private practice providers reported less difficulty implementing tele-mental
health than providers in other settings (P<.001). Overall, the majority (530/889, 59.62%) were interested in continuing to provide tele-mental health services in the future. The vast majority of mental health providers in this study made practice adjustments
in response to COVID-19, predominantly by transitioning to tele-mental health services. |
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Rhodes, RE, Liu, et al |
Appl Psychol Health Well Being |
Public Health response| Interventions de santé publique |
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32746455; Postdischarge venous
thromboembolism following hospital admission with COVID-19 |
Roberts, LN, Whyte, et al |
Blood |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
COVID-19 is associated with increased risk of venous thromboembolism (VTE), and the risk is highest among those with
critical care admission. Our local protocol provides thromboprophylaxis to COVID-19 patients during admission only. We report postdischarge VTE data from an ongoing quality improvement program incorporating root-cause analysis of hospital-associated VTE (HA-VTE).
Following 1877 hospital discharges associated with COVID-19, 9 episodes of HA-VTE were diagnosed within 42 days, giving a postdischarge rate of 4.8 per 1000 discharges. Over 2019, following 18 159 discharges associated with a medical admission; there were
56 episodes of HA-VTE within 42 days (3.1 per 1000 discharges). The odds ratio for postdischarge HA-VTE associated with COVID-19 compared with 2019 was 1.6 (95% confidence interval, 0.77-3.1). COVID-19 hospitalization does not appear to increase the risk of
postdischarge HA-VTE compared with hospitalization with other acute medical illness. |
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SARS-CoV-2 antibody testing in a UK population: detectable IgG for
up to 20 weeks post infection |
Robertson, LouiseJ, Moore, et al |
medRxiv |
Epidemiology| Épidémiologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes Immunology | Immunologie |
We measured SARS-CoV-2 antibody levels in plasma samples from 880 people in Northern Ireland by Roche Elecsys Anti-SARS-CoV-2
IgG/IgA/IgM, Abbott SARS-CoV-2 IgG and EuroImmun IgG SARS-CoV-2 ELISA immunoassays to analyse immune dynamics over time. Using these results, we develop a "pseudo gold standard" reference cohort against which to assess immunoassay performance. We report performance
metrics for the UK-RTC AbC-19 rapid lateral flow immunoassay (LFIA) against a characterised panel of 304 positives established using the "pseudo gold standard" system and 350 negative samples. We detect persistence of SARS-CoV-2 IgG up to 140 days (20 weeks)
post infection, across all three antibody immunoassays, at levels up to 4.4 times the cut-off for a positive result by Roche measurement. Using our "pseudo gold standard" cohort (n=348 positive, n=510 negative) we determine the sensitivity and specificity
of the three commercial immunoassays used (EuroImmun; Sens. 98.9% 97.7-99.7%]; Spec. 99.2% 98.4-99.8%]; Roche; Sens. 99.4% 98.6-100%]; Spec. (96.7% 95.1-98.2%]; Abbott; Sens. 86.8% 83.1-90.2%]; Spec. (99.2% 98.4-99.8%]). The UK-RTC AbC-19 lateral flow immunoassay
using shows a sensitivity of 97.70% (95.72%-99.34%) and specificity of 100% (100.00-100.00%). Through comprehensive analysis of a large cohort of pre-pandemic and pandemic individuals, we show detectable levels of IgG antibodies, lasting up to 140 days, providing
insight to immunity levels at later time points. |
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Rocha, HAL, Alcântara, et al |
Int J Qual Health Care |
Healthcare Response | Réponse des soins de santé |
This study aimed to assess an intervention to deal with the impact of the COVID19 pandemic on the operations of a rapid
response team (RRT). An observational study, using medical record review, was carried out at a large tertiary care hospital in Fortaleza. All adult patients admitted to hospital wards, treated by the RRTs during the study period, were included, and a total
of 15,461 RRT calls were analyzed. The hospital adjusted the size of its RRTs during the period, going from 2 to 4 simultaneous on-duty medical professionals. After the beginning of the pandemic, the number of treated cases in general went from an average
of 30.6 daily calls to 79.2, whereas the extremely critical cases went from 3.5 to 22 on average. In percentages, the extremely critical care cases went from 10.47 to 20%, with p <0.001. Patient mortality remained unchanged. The number of critically-ill cases
and the number of treated patients increased two-fold in relation to the pre-pandemic period, but the effectiveness of the RRT in relation to mortality was not affected. |
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Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19 |
Rodilla, E, Saura, et al |
J Clin Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of the study was to determine whether higher mortality associated with COVID-19 is due to increased prevalence
among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the
clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 ± 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%),
and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5, p = 0.0001), age tertiles (second and third tertiles, OR: 2.0 and 4.7, p = 0.0001), and Charlson Comorbidity Index scores (second and third tertiles,
OR: 4.7 and 8.1, p = 0.0001), hypertension was significantly predictive of all-cause mortality when this comorbidity was treated with angiotensin-converting enzyme inhibitors (ACEIs) (OR: 1.6, p = 0.002) or other than renin-angiotensin-aldosterone blockers
(OR: 1.2, p = 0.035). The preexisting condition of hypertension had an independent prognostic value for all-cause mortality in patients with COVID-19 who required hospitalization. |
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Romero-López, JP, Carnalla-Cortés, et al |
J Med Virol |
Coronavirology| Coronavirologie |
A bioinformatic prediction of T cell epitopes and their restricted HLA class I and II alleles was performed to obtain
immunogenic epitopes and HLA alleles from the spike protein of the SARS-CoV-2 virus. Also, a correlation with the predicted fatality rate of hospitalized patients in 28 states of Mexico was done. Here, we describe a set of ten highly immunogenic epitopes,
together with different HLA alleles that can efficiently present these epitopes to T cells. Most of these epitopes are located within the S1 subunit of the spike protein, suggesting that this area is highly immunogenic. A statistical negative correlation was
found between the frequency of HLA-DRB1*01 and the fatality rate in hospitalized patients in Mexico. |
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Root-Bernstein, R |
Vaccines |
Vaccine Research| Recherche sur les vaccins |
This paper explores the possibility that pneumococcal vaccines in particular, and other vaccines, contain antigens
that might be cross-reactive with SARS-CoV-2 antigens. Comparison of the glycosylation structures of SARS-CoV-2 with the polysaccharide structures of pneumococcal vaccines yielded no obvious similarities. However, while pneumococcal vaccines are primarily
composed of capsular polysaccharides, some are conjugated to cross-reacting material CRM197, a modified diphtheria toxin, and all contain about three percent protein contaminants, including the pneumococcal surface proteins PsaA, PspA and probably PspC. All
of these proteins have very high degrees of similarity, using very stringent criteria, with several SARS-CoV-2 proteins including the spike protein, membrane protein and replicase 1a. CRM197 is also present in Haemophilus influenzae type b (Hib) and meningitis
vaccines. Equivalent similarities were found at lower rates, or were completely absent, among the proteins in diphtheria, tetanus, pertussis, measles, mumps, rubella, and poliovirus vaccines. Notably, PspA and PspC are highly antigenic and new pneumococcal
vaccines based on them are currently in human clinical trials so that their effectiveness against SARS-CoV-2 disease is easily testable. |
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Roshan, A, Jeevitha, et al |
International Journal of Research in Pharmaceutical Sciences |
Healthcare Response | Réponse des soins de santé |
The aim of the study is to assess the awareness of infection control in dental practice in the COVID-19 outbreak among
dental practition-ers. A Self-administered questionnaire was designed based on awareness of infection control for a dental practice in the COVID-19 outbreak. The questionnaire was distributed through an online google form link. The study population included
dental professionals in Tamil Nadu. The data was collected and statistically analysed. 81% use PPE (personal protective equipment) during the procedure, 82.7% of patients are made to rinse their mouth with an antimicrobial mouth rinse before the dental procedure.
Based on the findings, awareness level and infection control in dental practice can be improved. |
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Rzepiński, Ł, Wawrzyniak, et al |
Neurol Neurochir Pol |
Clinical data| Données cliniques |
This letter to the editor describes a case report of a 42-year old woman with a diagnosis of generalised myasthenia
gravis who was exposed to three forms of immunosuppression and to a symptomatic infection with SARS-CoV-2 in the other members of her three-person household over a short period of time. |
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Sainsbury, C, Wang, et al |
Diabetes Obes Metab |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
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Saleh, M, Gabriels, et al |
Circ Arrhythm Electrophysiol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Hydroxychloroquine ± azithromycin have been widely used to treat COVID-19 despite a paucity of evidence regarding efficacy.
The incidence of torsade de pointes (TdP) remains unknown. COVID-19 positive patients that received hydroxychloroquine ± azithromycin across 13 hospitals between March 1(st) and April 15(th) were included in this study. A comprehensive search of the electronic
medical records was performed using a proprietary python script to identify any mention of QT prolongation, ventricular tachy-arrhythmias and cardiac arrest. The primary outcome of TdP was observed in 1 (0.015%) out of 6,476 hospitalized COVID-19 patients
receiving hydroxychloroquine ± azithromycin. Sixty-seven (1.03%) had hydroxychloroquine ± azithromycin held or discontinued due to an average QT prolongation of 60.5±40.5ms from a baseline QTc of 473.7±35.9ms to a peak QTc of 532.6±31.6ms. Of these patients,
hydroxychloroquine ± azithromycin were discontinued in 58 patients (86.6%), while one or more doses of therapy were held in the remaining nine (13.4%). A simplified approach to monitoring for QT prolongation and arrythmia was implemented on April 5(th). There
were no deaths related to the medications with the simplified monitoring approach and HCP exposure was reduced. The risk of torsade de pointes is low in hospitalized COVID-19 patients receiving hydroxychloroquine ± azithromycin therapy. |
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Epidemiological Correlates of PCR Cycle Threshold Values in the
Detection of SARS-CoV-2 |
Salvatore, PP, Dawson, et al |
Clin Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Using testing data collected during a prospective household transmission investigation of outpatient and mild COVID-19
cases, we examined the relationship between cycle threshold (Ct) values of the viral RNA N1 target and demographic, clinical, and epidemiological characteristics collected through participant interviews and daily symptom diaries. We found Ct values are lowest
(corresponding to higher viral RNA concentration) soon after symptom onset and are significantly correlated with time elapsed since onset (p<0.001); within 7 days after symptom onset, the median Ct value was 26.5 compared with a median Ct value of 35.0 occurring
21 days after onset. Ct values were significantly lower among participants under 18 years of age (p=0.01) and those reporting upper respiratory symptoms at the time of sample collection (p=0.001) and were higher among participants reporting no symptoms (p=0.05).
These results emphasize the importance of early testing for SARS-CoV-2 among individuals with symptoms of respiratory illness and allows cases to be identified and isolated when their viral shedding may be highest. |
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Sameer, AS, Khan, et al |
Ethics Med Public Health |
Public Health response| Interventions de santé publique |
Our study aimed to investigate the immediate impact of the COVID-19 pandemic enforced lockdown on mental health and
quality of life among general population aged 18 years and to identify various coping strategies used under lockdown. An online survey was conducted between 1st of April-10th of May, 2020; using a validated questionnaire based on DASS-42, employing a snowball
sampling technique. A total of 418 responses from 16 different countries were received. The respondents had a high level of depression and anxiety scores, which were significantly different among genders. Also, participants from developing countries-India
and Pakistan had severe depression while as participants from India, Pakistan and Kingdom of Saudi Arabia had severe anxiety. We also found that among the various coping strategies, (a) watching television for entertainment, (b) social networking, (c) listening
to music, (d) sleeping, (e) doing mundane house chores like cleaning, washing, etc. (f) eating well, and (g) clearing/finishing thepiled-up work were ranked among the most utilized coping strategies by all participants. |
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Sampogna, G, Tessitore, et al |
Spinal Cord Ser Cases |
Clinical data| Données cliniques |
The aim of our report is to provide our initial experience with individuals experiencing spinal cord dysfunction (SCD)
after COVID-19 in a referral center in Northern Italy, from February 21 to July 15, 2020. We report on three men with SCD after COVID-19. Case 1, aged 69 years, experienced T10 AIS B paraplegia upon awakening due to spinal cord ischemia from T8 to conus medullaris,
besides diffuse thromboses, 27 days after the onset of COVID-19 symptoms. Case 2, aged 56 years, reported progressive cervicalgia 29 days after COVID-19 onset associated with C3 AIS C tetraplegia. Magnetic resonance imaging (MRI) revealed a C4-C6 spinal epidural
abscess (SEA) requiring a C3-C4 left hemilaminectomy. Case 3, aged 48 years, reported backache together with lower limb muscle weakness on day 16 after being diagnosed with COVID-19. Exam revealed T2 AIS A paraplegia and an MRI showed a T1-T7 SEA. He underwent
a T3-T4 laminectomy. Prior to SCD, all three individuals suffered from respiratory failure due to COVID-19, required mechanical ventilation, had cardiovascular risk factors, experienced lymphopenia, and received tocilizumab (TCZ). Based on our experience,
we did not observe a direct viral infection, but there were two different etiologies. |
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Severe
Apparent Life-threatening Event (ALTE) in an Infant with SARS-CoV 2 Infection |
Sano, F, Yagasaki, et al |
Jpn J Infect Dis |
Clinical data| Données cliniques |
We describe SARS-CoV-2 infection in an infant who presented with a severe episode of apparent life-threatening event
(ALTE). An 8-month-old infant was transported to hospital because of sudden cardiopulmonary arrest. On arrival at our hospital, sever acidosis but no clear sign of inflammatory response was denoted. A chest computed tomography scan showed weak consolidations
in the upper right lung as well as atelectasis in the lower left lung. No sign of congenital heart disease or cardiomyopathy was observed in echocardiography, and no significant arrhythmia was observed in the later clinical course. Of note, the specific SARS-CoV-2
RNA was detected in both of her tracheal aspirate and urine sample by real-time RT-PCR. Although further accumulation of the cases is indispensable, our case suggests that SARS-CoV-2 infection may be one of the underlying factors in the pathophysiology of
ALTE. |
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Santos-Lozano, A, Calvo-Boyero, et al |
Clin Chem Lab Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This letter to the editor describes a retrospective study of all admitted patients diagnosed with COVID-19 (by PCR)
in a large public Hospital of Madrid, Spain (Hospital 12 de Octubre) from February 28 to March 30. The authors studied the prognostic value (in terms of survival) of potential “early” routine biochemistry and hematological biomarkers in patients with COVID-19.
Statistical analyses were performed in three stages. Data were analyzed for 1,369 patients (1,090 survivors [median time before discharge, 40 days] and 279 non-survivors [median time before death, 6 days]). This study provides useful information on which routine
laboratory variables determined at an early stage can predict a fatal outcome in patients with COVID-19. |
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A case of tocilizumab-induced leukoencephalopathy with
a reversible clinical course |
Sasaki, R, Hishikawa, et al |
Intern Med |
Clinical data| Données cliniques |
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Satış, H, Özger, et al |
Cytokine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Exuberant immune response with features of macrophage activation syndrome (MAS) lead detrimental consequences in COVID-19
patients. This study investigates the association of Interleukin (IL)-18 with the other inflammatory markers and disease severity in COVID-19 for predicting disease prognosis. Patients with a confirmed diagnosis with SARS-CoV-2 nucleic acid RT-PCR were enrolled
into the study. Data on demographic and clinical characteristics, and laboratory values of CRP, ferritin, d-dimer and procalcitonin were measured on admission. Patients were followed up prospectively with a standardized approach until hospital discharge or
death. Individuals were classified as asymptomatic, mild and severe pneumonia according to their clinical, laboratory and radiological characteristics. Worse outcome was defined as requirement of intensive care unit (ICU) admission or death. Blood samples
were collected at enrollment and serum levels of IL-6 and IL-18 were determined by ELISA. Association between IL-18 and other inflammatory markers and prognosis were analyzed. There were 58 COVID-19 patients (50% male) with a median age of 43 (min 22-max 81)
years. Twenty age and sex matched healthy subjects were served as control group. The study population was divided into three groups according to disease severity: asymptomatic (n = 20), mild pneumonia group (n = 27) and a severe group (n = 11). During follow
up nine (15.5%) patients required ICU admission and three of them were died eventually. Serum IL-18 were correlated with other inflammatory markers and biochemical markers of organ injury; creatinine, liver enzymes and troponin. Serum IL-18 levels were remarkably
higher in COVID-19 patients compared to healthy subjects with being highest in severe pneumonia group (p < 0.001). IL-18 serum concentrations were almost four-fold higher in patients with worse outcome compared to good outcome (p < 0.001). Serum IL-18 above
the cut off value of 576 pg/mL on admission was associated with 11.7 fold increased risk of ICU admission. The serum concentrations of IL-18 correlate with other inflammatory markers and reflect disease severity. |
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Scarpina, F |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
In this observational study, the psychological ability to recognize the others’ fearful expressions in Italian individuals
during the pandemic COVID-19 lockdown was explored through a behavioral task performed online. An implicit version of the traditional facial emotion recognition task, grounded on the attentional and unconscious mechanism of the redundant target effect, was
used. The experiment was scripted through the free software OpenSesame (Mathôt et al., 2012) and published on the Internet through the free software Jatos (Lange et al., 2015). The Reaction Time and level of Accuracy in detecting fearful expressions were computed.
Overall, the data of 86 Italian individuals were collected. When their performance was scored in terms of Reaction Time, the redundant target effect did not emerge; instead, the expected effect was observed when the level of Accuracy was considered. Overall,
the performance registered in this Italian sample in terms of accuracy was in line with previous results reported in Scarpina et al. (2018), in which a long extended version of the same behavioral task was used in a traditional experimental setting. |
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Schmidtke, HR |
Journal of Reliable Intelligent Environments |
Public Health response| Interventions de santé publique |
Commercial web-based location-aware applications both collect data and—through spatial analysis and connection to services—provide
value to users. This value is what motivates users to share increasingly private and comprehensive data. The willingness of users to share data in return for services has been a key concern with web-based variants of the technology since the beginning. With
a focus on two privacy preserving CoViD-19 contact tracking applications, this survey walks through the key steps of developing a privacy preserving context-aware application: from types of applications and business models, through architectures and privacy
strategies, to representations. |
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A Novel Use of Romiplostim
for SARS-CoV-2-induced Thrombocytopenia |
Schneider, CW, Penney, et al |
J Pediatr Hematol Oncol |
Clinical data| Données cliniques |
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Secchi, M, Bazzigaluppi, et al |
J Clin Invest |
Clinical data| Données cliniques Immunology | Immunologie |
This study aimed to define previous exposure to SARS-CoV-2 in populations and to verify the development of an adaptive
immune response in infected individuals using serological assays.We studied 509 confirmed COVID-19 patients from the San Raffaele Hospital of Milan and 480 pre-pandemic organ donor sera collected in 2010-2012. Using fluid-phase luciferase immune precipitation
(LIPS) assays, we characterized IgG, IgM, IgA antibodies to the spike Receptor Binding Domain (RBD), S1+S2, nucleocapsid, and ORF6 to 10 of SARS-CoV-2, to the HCoV-OC43 and HCoV-HKU1 betacoronaviruses spike S2, and the H1N1Ca2009 flu virus hemagglutinin. Sequential
samples at 1 and 3 months post-hospital discharge were also tested in 95 patients for SARS-CoV-2 RBD antibodies. Antibodies developed rapidly against multiple SARS-CoV-2 antigens in 95% of patients by 4 weeks post-symptoms onset and IgG to the RBD increased
until the 3rd month of follow-up. We observed a major synchronous expansion of antibodies to the HCoV-OC43 and HCoV-HKU1 spike S2. A likely co-infection with influenza was neither linked to a more severe presentation of the disease nor to a worse outcome.
Of the measured antibody responses positivity for IgG against the SARS-CoV-2 spike RBD was predictive of survival. The measurement of antibodies to selected epitopes of SARS-CoV-2 antigens can offer a more accurate assessment of the humoral response in patients
and its impact on survival. |
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Shahbazi, F, Khazaei, et al |
New Microbes New Infect |
Epidemiology| Épidémiologie |
This study aimed to identify the role of the human development index (HDI) in the incidence and mortality rates of
COVID-19 worldwide. Information on the incidence and mortality rates of COVID-19 was obtained from the Worldometer and data about the HDI 2019 were obtained from the World Bank database. Correlations between incidence, mortality rates and HDI parameters were
assessed using linear regression. We calculated the concentration index to measure socio-economic inequality in COVID-19-related mortality and incidence. A linear regression analysis showed a direct significant correlation between the incidence and mortality
rate of COVID-19 and HDI at the global level. The concentration index was positive for incidence rate (0.62) and mortality rate (0.69) of COVID-19, indicating the higher concentration of the rates among groups with high HDI. The high incidence and mortality
rates of COVID-19 in countries with high and very high HDI are remarkable and should be the top priority for interventions by global health policy-makers. |
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Shankar, P, Abilasha, et al |
International Journal of Research in Pharmaceutical Sciences |
Healthcare Response | Réponse des soins de santé |
The research aimed to assess and improve knowledge about universal precautions among health care personnel to reduce
the rate of harmful exposure and infections among them. A questionnaire comprising 20 questions was created and circulated among 100 health care workers through the online platform ”Google forms”. The results were collected and analysed. Statistical analysis
was performed using SPSS. It was evident that many people were not aware of the seriousness of universal precautions. Results indicate that many medical personals followed and were aware of universal precaution to an extent. |
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In Situ Simulation:
An Essential Tool for Safe Preparedness for the COVID-19 Pandemic |
Sharara-Chami, R, Sabouneh, et al |
Simul Healthc |
Healthcare Response | Réponse des soins de santé |
In this article, we describe our ongoing simulation activities to ensure that our staff is best prepared to adapt to
the challenges of COVID-19. This is a prospective preparedness assessment and training intervention at a tertiary care academic center in Lebanon during the COVID-19 pandemic. In situ simulations followed by debriefing with good judgment occur daily involving
native teams of 3 to 5 professionals in the newly established COVID intensive care unit and wards, the adult and pediatric intensive care unit and wards, and the emergency department. The simulations are assessed by the instructor using the Simulation Team
Assessment Tool and by the participants using the Simulation Effectiveness Tool. Transcripts of recorded simulation debriefings are analyzed for content for latent safety threats using the SHELL Framework (Software-Hardware-Equipment-Liveware). In 2 weeks,
we conducted 15 simulations with 106 participants and 47 observers. Simulation Team Assessment Tool scores show an overall improvement across the hospital over time 101.5 ± 13 (80-134)]. Participants' feedback on the Simulation Effectiveness Tool has been
predominantly positive on the educational and practical benefits of the simulation activity. Data from debriefings and observations demonstrated the following categories of latent safety threats: inadequate preparedness on infection control, uncertainty of
guidelines on oxygen supplementation and intubation protocols, lack of leadership and communication, overall panic, and others. |
|
Sharma, Shubham, Pinto, et al |
ArXiv |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Show that a single layer of a surgical mask can atomize a cough droplet into numerous tiny droplets, thereby significantly
increasing the total population of aerosols ejected during a single human cough. The single-layer masks were found to be ineffective in restraining cough droplets while no penetration could be noticed for a triple-layer mask. This is because a single-layer
or double-layer face mask causes atomization of the droplets resulting in the formation of larger number of droplets with smaller sizes (< 100 {\mu}m). These tiny droplets can aerosolize in the immediate environment and can remain suspended for a longer time. |
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Sharma, SV, Haidar, et al |
PLoS One |
Public Health response| Interventions de santé publique |
Administered a rapid assessment survey to identify social needs among their families. 71 families were triaged and
classified as "high risk" (6.8% of survey respondents). During the time of "shelter in place" orders, 100% of the "high risk" participants reported being food insecure, 85% were concerned about their financial stability, 82% concerned about the availability
of food, and 65% concerned about the affordability of food. A qualitative analysis of the high-risk group revealed four major themes: fear of contracting COVID19, disruption of employment status, financial hardship, and exacerbated food insecurity. |
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Prediction of adverse clinical outcomes in patients with coronavirus disease 2019 |
Shi, S, Liu, et al |
J Clin Lab Anal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Investigated blood and biochemical laboratory findings in patients with coronavirus disease (COVID-19) and analyze
the potential predictors of poor outcome. On the univariate analysis, age, white blood cell (WBC) count, neutrophil counts, lymphocytes count, neutrophils-to-lymphocytes ratio (NLR), interleukin-6, albumin-to-globulin ratio (AGR), albumin, lactate dehydrogenase,
glutamyl transpeptidase, and blood glucose were found to be the significant predictors. On the multivariate analysis, the predictors of poor outcome of patients with COVID-19 were NLR and IL-6. High interleukin-6 (6 pg/mL, cuff value) and NLR (4.48, cuff value)
can be used to predict poor outcomes in patients with COVID-19 on admission. |
|
Shi, TH, Huang, et al |
Biochemical and biophysical research communications |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Demonstrate that both andrographolide and its fluorescent derivative, the nitrobenzoxadiazole-conjugated andrographolide
(Andro- NBD), suppressed the main protease (Mpro) activities of 2019-nCoV and severe acute respiratory syndrome coronavirus (SARS-CoV). Consistently, molecular modeling analysis supported the docking of andrographolide within the catalytic pockets of both
viral Mpros. Considering that andrographolide is used in clinical practice with acceptable safety and its diverse pharmacological activities that could be beneficial for attenuating COVID-19 symptoms. |
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Impact of Poverty on COVID-19 Infections and Fatalities: A Regional Perspective |
Siddique, Abu Bakkar, Haynes, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Economics | Économie |
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32925138; Knowledge and practice regarding prevention of COVID-19 among the Saudi Arabian population |
Siddiqui, AA, Alshammary, et al |
Work (Reading, Mass.) |
Public Health response| Interventions de santé publique |
Examined the existence of knowledge among the Saudi and non-Saudi nationals about COVID-19 and its impact on their
behavior to practice the protocols to prevent COVID-19 spread. 84% knew they had to wash their hands for 20 seconds and did this as well, 75% knew that sneezing or coughing into the arm/elbow can prevent the spread of COVID-19 and were doing this as well,
82% knew that COVID-19 can be transferred by shaking hands and avoided this, 79% knew that they had to maintain a safe distance of at least one meter and kept this distance, 76% knew that touching one's face can transfer the virus and avoid this, and 95% knew
that staying at home can decrease the chances of getting infected. The level of education of the respondents influenced their choice of practice to protect themselves. |
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Siddiqui, R, Khamis, et al |
ACS Chem Neurosci |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Several lines of evidence suggest the role of air-conditioning systems in the transmission of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). Furthermore, the likelihood of novel coronavirus to take refuge inside a microbial Trojan horse, that is, Acanthamoeba, can further enhance possibility of SARS-CoV-2 transmission in the environment. Here we propose the
use of various disinfection strategies that can be employed using filters with antimicrobial fabricated surfaces or using UV irradiation to achieve germicidal properties for removal of pathogenic microbes such as SARS-CoV-2 and amoebae in the ventilation systems. |
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Siegler, JE, Cardona, et al |
Int J Stroke |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Summarize the findings of a multinational observational cohort of patients with SARS-CoV-2 and cerebrovascular disease.
Of the 14,483 patients with laboratory-confirmed SARS-CoV-2, 172 were diagnosed with an acute cerebrovascular event (1.13% of cohort). Of these, 156 had acute ischemic stroke (1.08%), 28 ICH (0.19%) and 3 with CVST (0.02%). The in-hospital mortality rate for
SARS-CoV-2-associated stroke was 38.1% and for ICH 58.3%. COVID-19 is associated with a small but significant risk of clinically relevant cerebrovascular events, particularly ischemic stroke. The mortality rate is high for COVID-19-associated cerebrovascular
complications. |
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Liver transplantation in Italy in the era of COVID 19: reorganizing critical care of recipients |
Siniscalchi, A, Vitale, et al |
Internal and Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
Propose a management model for the reorganization of liver transplant (LT) activities and policies in a local intensive
care unit (ICU) assigned to liver transplantation affected by restrictions on mobility and availability of donors and recipients as well as health personnel and beds. During the 2020 study period, 38 LTs were performed, whereas 41 were performed in 2019. Patients
transplanted during the COVID-19 pandemic had higher MELD and MELD-Na scores, cold ischaemia times, and hospitalization rates (p < 0.05); accordingly, they spent fewer days on the waitlist and had a lower prevalence of hepatocellular carcinoma (p < 0.05).
No transplanted patients contracted COVID-19, although five healthcare workers did. Ultimately, our policy allowed us to continue the ICU’s operations by prioritizing patients hospitalized with higher MELD without any case of transplant infection due to COVID-19 |
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Sixt, T, Moretto, et al |
J Infect |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Evaluate if National Early Warning Score 2 (NEWS2) could predict outcome of COVID-19 at day 28 and look for the earliest
time point of assessment which could be used as a strong surrogate marker of day 28 evolution. NEWS2 was calculated at admission, at day (D) 7 and D14 of hospitalization. With the total score, patients were classified into 3 groups of risk: low risk from 0
to 4; medium risk from 5 to 6 and high risk above 7. An unfavourable event (defined as death or transfer to ICU) was observed in 64 patients (29%), 52 during the first week and, 12 in the second week of hospitalization. For the 170 patients who did not present
with any unfavourable event within the first week of hospitalization, 154 (90%) had a NEWS2<7 at D7. Such a score could thus be used to allow earlier discharge of the patients and as a judgement criterion in therapeutic trials. |
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Slaine, PatrickD, Kleer, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Enveloped viruses utilize the host cell secretory pathway to synthesize viral glycoproteins and direct them to sites
of assembly. Using an image-based screen, we identified two thiopurines, 6-thioguanine (6-TG) and 6-thioguanosine (6-TGo), that selectively disrupted the processing and accumulation of influenza A virus glycoproteins hemagglutinin (HA) and neuraminidase (NA).
Selective disruption of IAV glycoprotein processing and accumulation by 6-TG and 6-TGo correlated with unfolded protein response (UPR) activation. 6-TG and 6-TGo also inhibited replication of the human coronavirus OC43 (HCoV-OC43), which correlated with UPR/ISR
activation and diminished accumulation of ORF1ab and nucleocapsid (N) mRNAs, which suggests broader disruption of coronavirus gene expression in ER-derived cytoplasmic compartments. The chemically similar thiopurine 6-mercaptopurine (6-MP) had little effect
on the UPR and did not affect IAV or HCoV-OC43 replication. Consistent with reports on other CoV Spike (S) proteins, ectopic expression of SARS-CoV-2 S protein caused UPR activation. 6-TG inhibited accumulation of full length S0 or furin-cleaved S2 fusion
proteins, but spared the S1 ectodomain. DBeQ, which inhibits the p97 AAA-ATPase required for retrotranslocation of ubiquitinated misfolded proteins during ER-associated degradation (ERAD) restored accumulation of S0 and S2 proteins in the presence of 6-TG,
suggesting that 6-TG induced UPR accelerates ERAD-mediated turnover of membrane-anchored S0 and S2 glycoproteins. Taken together, these data indicate that 6-TG and 6-TGo are effective host-targeted antivirals that trigger the UPR and disrupt accumulation of
viral glycoproteins. Importantly, our data demonstrate for the first time the efficacy of these thiopurines in limiting IAV and HCoV-OC43 replication in cell culture models.Competing Interest StatementThe authors have declared no competing interest. |
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Smith, LE, Woodland, et al |
BMJ Paediatrics Open |
Public Health response| Interventions de santé publique |
During the early stages of the COVID-19 pandemic, schools in England were only kept open to children of key workers'
and, from 1 June, to children in reception, year 1 and year 6. Our cross-sectional survey of parents found low rates of attendance (<50%) in both groups. Many parents whose children attended school reported low adherence to hygiene measures (eg, not maintaining
distance from others during school drop-off) and doubted that their school was adhering to COVID-19 guidelines. This must be improved if parents are to feel confident about a more comprehensive return to school, as planned for September. © 2017 BMJ Publishing
Group. All rights reserved. |
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Speake, H, Phillips, et al |
Emerg Infect Dis |
Epidemiology| Épidémiologie Transmission Coronavirology| Coronavirologie |
To investigate potential transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during a domestic
flight within Australia, we performed epidemiologic analyses with whole-genome sequencing. Eleven passengers with PCR-confirmed SARS-CoV-2 infection and symptom onset within 48 hours of the flight were considered infectious during travel; 9 had recently disembarked
from a cruise ship with a retrospectively identified SARS-CoV-2 outbreak. The virus strain of those on the cruise and the flight was linked (A2-RP) and had not been previously identified in Australia. For 11 passengers, none of whom had traveled on the cruise
ship, PCR-confirmed SARS-CoV-2 illness developed between 48 hours and 14 days after the flight. Eight cases were considered flight associated with the distinct SARS-CoV-2 A2-RP strain; the remaining 3 cases (1 with A2-RP) were possibly flight associated. All
11 passengers had been in the same cabin with symptomatic persons who had primary, culture-positive, A2-RP cases. This investigation provides evidence of flight-associated SARS-CoV-2 transmission. |
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Ethical dilemmas, perceived risk, and motivation among nurses during the COVID-19 pandemic |
Sperling, D |
Nurs Ethics |
Healthcare Response | Réponse des soins de santé |
Examined how Israeli nurses respond to ethical dilemmas and tension during the COVID-19 outbreak, and to what extent
this is associated with their perceived risk and motivation to provide care. 68.8% of the respondents had received some form of training about COVID-19. Respondents positioned themselves at perceived high risk levels for contracting the virus. About one-third
feared going to work because of potential contraction and due to feeling inadequately protected. While 40.9% were scared to care for COVID-19 patients, 74.7% did not believe they have the right to refuse to treat certain patients. 81.4% believed that every
patient has the right to receive optimal treatment, regardless of their age and medical background. Nurses did not convey intention to leave the profession despite their stress, perceived risk, and feelings of insufficient support and protection at work. |
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Acute Care of Older Patients with COVID-19: Clinical Characteristics and Outcomes |
Steinmeyer, Z, Vienne-Noyes, et al |
Geriatrics (Basel) |
Clinical data| Données cliniques |
Describe clinical characteristics and outcomes of older patients hospitalized with COVID-19. Ninety-four patients were
hospitalized and included in the final analysis. A majority of patients were dependent (77%), 45% were malnourished, and the mean number of comorbidities was high in accordance with the CIRS-G score (12.3 ± 25.6). The leading causes of hospitalization were
fever (30%), dyspnea (28%), and geriatric syndromes (falls, delirium, malaise) (18%). Upon follow-up, 32% presented acute respiratory failure and 30% a geriatric complication. Frailty and geriatric characteristics were not correlated with mortality. Acute
respiratory failure (p = 0.03) and lymphopenia (p = 0.02) were significantly associated with mortality. |
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Stephens, JR, Stümpfle, et al |
Crit Care Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Performed a retrospective analysis of the APACHE II (2013), Simplified Acute Physiology Score (SAPS) II, and ICNARC
(2013) scores of all critically unwell patients with COVID-19 admitted to ICUs across three teaching hospitals in London from March 10, 2020, to May 22, 2020, paying particular interest to nonsurvivors to assess whether the index critical illness scores were
indicative of disease severity. Patients also had relatively low median severity of illness scores (APACHE II 16.0, SAPS II 29, ICNARC 22.5) despite an overall mortality of 37.6%. Furthermore, our results demonstrate that APACHE II, SAPS II, and ICNARC scores
are also unusually low in nonsurvivors with COVID-19. Data suggest that these scores in their current form may be unsuitable for these purposes in COVID-19 patients, grossly underestimating actual mortality risk and poorly stratifying disease severity. |
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Bridging the gap between social and health vulnerability in
rural India: A case of COVID-19 |
Surendra, S |
Disaster Advances |
Public Health response| Interventions de santé publique |
The present study made an attempt to bridge the gap between health and social vulnerability using field survey data
of five village of Mathura district of Uttar Pradesh. A total of 150 samples were collected during February and March 2020. The study results highlights that households are highly exposed to novel Covid-19 and sensitive to inadequate access of clean water
and sanitation. Households undertook a range of preventive measures including health insurance, balance diet, stored food items, consultation to doctors, self-quarantine to overcome the stress of Covid-19. The calculated livelihood vulnerability scores show
that households belonging to Virjapur village are relatively highly vulnerable than others |
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Susilkumar, V, Vengadassalapathy, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
Investigated the knowledge, attitudes, practices and psychological response of the people towards the ongoing novel
COVID-19 pandemic crisis. Around 69% of the respondents are aware of the clinical symptoms of COVID-19. And about 98% of the respondents believe that quarantine and self-isolation are the best way to contain the spread of COVID-19. Around 90%-92% of the participants
have an optimistic, positive attitude and confidence that we will win the battle against COVID-19. The study revealed that majority of the respondents had positive psychological resilience to cope with the pandemic. |
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Awareness on possible ayurvedic treatment to prevent COVID-19-a survey |
Sutharshan, GS, Sasanka, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
The study aims to be aware of possible Ayurvedic treatment to prevent COVID-19. An online survey was conducted with
a self-structured questionnaire. The responses recorded from the participants showed that the participants possess adequate knowledge about the covid19 infection, and they possess sufficient awareness of the possible role of Ayurveda on boosting immunity against
COVID-19. Around 68% of the respondents showed positive responses towards ayurvedic treatment to prevent COVID-19. Showing responses for questions about diet patterns, plays a vital role in preventing COVID19-positive responses is 41%. The study concluded
that during this pandemic out-break, most of the participants are aware of the origin, cause, mode of the spread, treatment options and the initiatives taken by the government to prevent this pandemic |
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On the optimal control of coronavirus (2019-nCov) mathematical model; a numerical approach |
Sweilam, NH, Al-Mekhlafi, et al |
Advances in Difference Equations |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
In this paper, a novel coronavirus (2019-nCov) mathematical model with modified parameters is presented. This model
consists of six nonlinear fractional order differential equations. Optimal control of the suggested model is the main objective of this work. Two control variables are presented in this model to minimize the population number of infected and asymptotically
infected people. Necessary optimality conditions are derived. The Grünwald–Letnikov nonstandard weighted average finite difference method is constructed for simulating the proposed optimal control system. The stability of the proposed method is proved. In
order to validate the theoretical results, numerical simulations and comparative studies are given. © 2020, The Author(s). |
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Tang, YF, Jiang, et al |
World Chinese Journal of Digestology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Performed a retrospective analysis of COVID-19 cases to identify the risk factors for liver injury. Of the 100 COVID-19
patients included, 54% were male and 46% were female. Abnormal liver function was observed in 38 patients, including elevated alanine aminotransferase (ALT; 28 patients), aspartate aminotransferase (AST; 10 patients), and gamma-glutamyl transferase (GGT; 20
patients). Patients who had elevated ALT, AST, or GGT were significantly more often present in male patients (P < 0.001, P = 0.006 and P < 0.001, respectively). There was no statistical difference in liver function parameters between patients who received
and did not receive prehospital treatment. |
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Tanveer, M, Hassan, et al |
Academy of Strategic Management Journal |
Public Health response| Interventions de santé publique |
Describe how the COVID-19 and quarantine has influenced consumer behavior and similarly if these ultimately make the
sustainability of Business Empire in Saudi Arabia go downwards or not. The customer behavior was found very poor towards the business development as the presumption has been believed, and this weakens the market world economy in the region. COVID-19 keeps
the customers at home but the demands are continuously raising online purchasing and home delivery. Conversely Because of reduced of purchasing because of not having much experience of online shopping and home delivery. Due to COVID-19 people were very choosy
to buy products that had great impact on business sustainability and development and consumer behavior were found negative. |
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Taylor, J, Carter, et al |
Morbidity and Mortality Weekly Report |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie Healthcare Response | Réponse
des soins de santé |
Facility-wide, serial testing in skilled nursing facilities (SNFs) can identify asymptomatic SARS-CoV-2 infections
among health care personnel (HCP) and residents to inform mitigation efforts. Serial facility-wide testing at two Minnesota SNFs identified COVID-19 cases among 64% of residents and 33% of HCP. Genetic sequencing found facility-specific clustering of viral
genomes from HCP and residents’ specimens, suggesting intrafacility transmission. HCP working in SNFs are at risk for infection during COVID-19 outbreaks. To protect residents and prevent SARS-CoV-2 infection among HCP, SNFs need enhanced infection prevention
and control practices, assured availability of personal protective equipment, improved HCP testing participation, flexible medical leave, and timely result reporting. |
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Thom, C, Deshmukh, et al |
medRxiv |
Healthcare Response | Réponse des soins de santé |
Developed a Neonatal-Infant Airway Safety Program to improve medical responses, communication, equipment usage and
outcomes for infants requiring emergent airway interventions. Since 2008, there were 159 airway emergency events in our NICU (~12 per year). Mean specialist response times decreased from 5.9±4.9 min (2008-2012, mean±SD) to 4.3±2.2 min (2016-2019, p=0.12),
and the number of incidents with response times >5 min decreased from 28.8±17.8% (2008-2012) to 9.3±11.4% (2016-2019, p=0.04 by linear regression). As our program became more standardized, we noted better equipment availability and subspecialist communication.
Few emergency situations (n=9, 6%) required operating room management. There were 3 patient deaths (2%). |
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Tian, J, Xu, et al |
Curr Med Res Opin |
Clinical data| Données cliniques |
Compare clinical features in adult patients with coronavirus disease 2019 (COVID-19) pneumonia to those in adult patients
with community-acquired pneumonia (CAP). Patients with COVID-19 pneumonia had lower levels of abnormal laboratory parameters white blood cell count, lymphocyte count, procalcitonin level, erythrocyte sedimentation rate, and C-reactive protein level] and more
extensive radiographic involvement. More severe respiratory compromise resulted in a higher rate of intensive care unit admission, acute respiratory distress syndrome (ARDS), and mechanical ventilation (36% vs 15%, 34% vs 15%, and 32% vs 12%, respectively;
all p < 0.05). The 30-day mortality was more than twice as high in patients with COVID-19 pneumonia (12% versus 5%; p = 0.063), despite not reaching a statistically significant difference. |
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Tokocin, M, Aktokmakyan, et al |
Indian Journal of Surgical Oncology |
Healthcare Response | Réponse des soins de santé |
Aimed to address cancer-related operations during the COVID-19 outbreak. A total of 26 cases of COVID-19 were enrolled
in the study. Seventeen (65%) were female, and 9 (35%) were male. The mean age was 52.4 (range 28–74). The mean body mass index (BMI) is 27.8 kg/m2 (range 17.6–34.0). Eight of them had comorbidities. 7 patients needed an intensive care unit (ICU). Only one
patient was COVID-19 positive in the PCR test, while the others were negative. In addition to this patient, 3 other patients were COVID-19 positive on computed tomography (CT). The patients included in this study underwent various oncologic surgery procedures.
While 24 patients were discharged without any problems, 2 patients developed complications. Due to respiratory problems, the patient could not get out of intensive care and died on the sixth postoperative day. |
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Assessment and Characterization of Post-COVID-19 manifestations |
Tolba, M, Abo Omirah, et al |
Int J Clin Pract |
Clinical data| Données cliniques |
The study aims to investigate and characterize the manifestations which appear after eradication of the coronavirus
infection and its relation to disease severity. 287 survivors from COVID-19 were included in the study, each received a questionnaire divided into three main parts starting from subjects' demographic data, data about the COVID-19 status and other comorbidities
of the subject, and finally data about post-COVID-19 manifestations. Response surface plots were produced to visualize the link between several factors. 10.8 % of all subjects have no manifestation after recovery from the disease while a large percentage of
subjects suffered from several symptoms and diseases. The most common symptom reported was fatigue (72.8 %), more critical manifestations like stroke, renal failure, myocarditis, and pulmonary fibrosis were reported by a few percent of the subjects. There
was a relationship between the presence of other comorbidities and severity of the disease. Also, the severity of COVID-19 was related to the severity of post-COVID-19 manifestations. |
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Tomaszek, K, Muchacka-Cymerman, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique |
The main aim of this study was to test the mediating effect of existential anxiety, activated by COVID-19 and life
satisfaction (SWLS) on the relationship between PTSD symptoms and post-traumatic growth (PTG). We also examined the moderated mediating effect of severity of trauma symptoms on life satisfaction and existential anxiety and its associations with PTG. We conducted
an online survey during the peak of the COVID-19 outbreak in Poland. The participants completed existential anxiety scale (SNE), life satisfaction scale (SWLS), IES-R scale for measuring the level of PTSD symptoms and post-traumatic growth inventory (PTGI).
The effect of PTSD on PTG was found to be mediated by existential anxiety and life satisfaction. We also confirmed two indirect effects: (1) the indirect effect of PTSD on PTG via existential anxiety and life satisfaction tested simultaneously; (2) the indirect
effect of life satisfaction on PTG through severity of trauma symptoms. An intermediate or high level of PTSD level was related to less PTG when low and full PTSD stress symptoms strengthened PTG experiences. |
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Tsugawa, A, Sakurai, et al |
Journal of Alzheimer's disease : JAD |
Public Health response| Interventions de santé publique |
We investigated the association between rate of awareness of COVID-19 and depressive tendency in Alzheimer's disease
(AD). 126 consecutive outpatients with AD were enrolled in this study from May 25, on the day when the declaration of emergency was lifted in Japan, through June 30, 2020. Moderate to severe AD patients were found to have a low COVID-19 recognition rate and
did not fully understand why they were wearing face masks. In addition, because they did not understand the seriousness of the COVID-19 outbreak, their Geriatric Depression Scale scores were also substantially lower. |
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Lung Ultrasound Findings in a Covid-19 Patient with Negative Chest CT |
Tung Chen, Y, Martí de Gracia, et al |
Ultraschall Med |
Clinical data| Données cliniques |
A case report of a healthy 27 year old male nurse who was positive for COVID-19. Chest X rays and CT scans of lungs
were normal but conditions worsened. Report that lung ultrasound (LUS) showed pathologic findings which corresponded well with symptoms. |
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Uluçay, DM, Melek, et al |
Tripodos |
Public Health response| Interventions de santé publique |
The aim of this research is to examine the role that data visuals in media coverage play on the risk perception of
the public in times of a pandemic. The article reports findings from an online survey of 191 adults regarding the trajectory of the risk perception model during COVID-19 pandemic in Turkey. We focused on eight statements clustered into three groups as indicators
of the risk perception when the public came across with the data visuals: (1) the level of anxiety, fear and panic arousals, (2) the level of lacking credibility and trust and (3) the level of impression regarding fatality, irreversible effects and catastrophic
consequences. The results suggest that the respondents find the data presented in visuals credible and trustworthy and they agree that the visuals depict risk elements in many cases. |
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Umar, Z, Gubareva, et al |
J Behav Exp Finance |
Economics | Économie |
We apply wavelet analyses to examine the impact of the Covid-19 fueled panic on the volatility of major fiat and cryptocurrency
markets during January-May, 2020. There is high coherence between moves of the Coronavirus Panic Index and the price moves in Euro, British pound, and Renminbi currencies as well as movements of the Bloomberg Galaxy Crypto Index. The main conclusions for each
index pair are quite similar and corroborate with our thesis that the cross-currency hedge strategies, which could work under normal market conditions, are likely to fail during the periods of global crisis, e.g., such as the Covid-19 pandemic. However, we
document some important differences in currency markets behavior, which potentially could be used to design effective cross-currency hedges capable of withstanding adverse impacts of global financial and economic turmoil. Our findings could be of use for future
development of financial policies and currency markets regulation rules. |
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Vagni, M, Maiorano, et al |
Sustainability (Switzerland) |
Healthcare Response | Réponse des soins de santé |
We aimed to explore the relationship of emergency stress, hardiness, coping strategies, and secondary trauma among
emergency workers and the mediating roles of coping strategies and hardiness on the effect of stress in producing secondary trauma. The study involved 513 emergency workers from the Red Cross Committee in Veneto, one of the Italian regions most affected by
the COVID-19. Participants completed questionnaires online to measure emergency stress, hardiness, coping strategies, and secondary trauma. Other variables analyzed were age, gender, weekly hours of service, and use of PPE. We performed t-tests, a correlational
analysis, regressions, and a mediation analysis. Hardiness and coping strategies, in particular, which stop unpleasant emotions and thoughts and problem-focused, emerged as mediators in reducing the predicted effect of stress on secondary trauma. The mediating
effects of hardiness and coping strategies were found to reduce the effect of stress on arousal by 15% and the effect on avoidance by 25%. |
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Vassallo, M, Manni, et al |
Int J Infect Dis |
Clinical data| Données cliniques Immunology | Immunologie |
We identified subjects admitted for Covid-19 in whom a large panel of immunological markers were measured, including
B- and T- and NK-lymphocyte phenotypes, T-lymphocyte subpopulation cells and plasma cytokines. Patients were divided according to symptom severity during hospitalisation, in those with uncomplicated and complicated infection. Differences between groups were
analyzed. Seventeen patients were included (mean age: 83 years; 9 women; mean delay of symptoms onset: 4 days). Six had uncomplicated infection, while 11 developed complicated forms during the hospitalization. CD10 + B lymphocyte levels were inversely correlated
with clinical severity (5.8% vs 2.0%, p = 0.04) and CD10+ levels above 3% were independently associated with uncomplicated forms Odds Ratio 0.04 (CI 0.002-0.795, p = 0.034)]. TNF-alpha, IL-1, Il-6 and Il-8 measurements upon admission differed between patients
who died and those who survived (p < 0.01 for all comparisons). In a population of elderly patients recently infected with Covid-19, CD10 + B cell levels were inversely correlated with clinical severity. Cytokine values upon admission were highly predictive
of fatal outcome during hospitalisation. |
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Vassiliou, AG, Jahaj, et al |
Metabolites |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective, observational study we assessed whether lactate is associated with outcomes in COVID-19 patients.
Blood lactate was measured on ICU admission and thereafter daily up to day 14 in 45 patients with confirmed COVID-19 pneumonia. Acute physiology and chronic health evaluation (APACHE II) was calculated on ICU admission, and sequential organ failure assessment
(SOFA) score was assessed on admission and every second day. The cohort was divided into survivors and non-survivors based on 28-day ICU mortality (24.4%). Cox regression analysis revealed that maximum lactate on admission was independently related to 28-day
ICU mortality with time in the presence of APACHE II (RR = 2.45, p = 0.008). Lactate’s area under the curve for detecting 28-day ICU mortality was 0.77 (p = 0.008). Mixed model analysis showed that mean daily lactate levels were higher in non-survivors (p
< 0.0001); the model applied on SOFA scores showed a similar time pattern. |
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Vella, L, Giles, et al |
medRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
We analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients and patients with
Multisystem Inflammatory Syndrome in Children (MIS-C). MIS-C patients had patterns of T cell-biased lymphopenia and T cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike-specific antibodies at admission. A distinct
feature of MIS-C patients was robust activation of vascular patrolling CX3CR1+ CD8 T cells that correlated with use of vasoactive medication. Finally, whereas pediatric COVID-19 patients with acute respiratory distress syndrome (ARDS) had sustained immune
activation, MIS-C patients displayed clinical improvement over time, concomitant with decreasing immune activation. Thus, non-MIS-C versus MIS-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct and
implicate CD8 T cells in clinical presentation and trajectory of MIS-C. |
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QTc Interval and Mortality in a Population of SARS-2-COV Infected Patients |
Vicentini, A, Masiello, et al |
Circ Arrhythm Electrophysiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
No abstract provided and full text not available as open access. |
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Villena-Alarcón, E, Caballero-Galeote, et al |
Tripodos |
Public Health response| Interventions de santé publique |
This research seeks to examine the coronavirus media coverage on the Spanish public TV (TVE1). In order to achieve
this goal, a content analysis based on the five stages of grief, an audience survey, and focus group interviews were conducted. The results have shown that coverage has undergone different phases. Accordingly, each of these stages has been perceived by the
audience. Although both the audience and the experts appreciate the work of Spanish public television, the majority opinion is negative. In this regard, they state that it has not been impartial and there has been an excess of information. |
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32955912; Clinical characteristics of SARS-CoV-2 infection in a rural area in Germany |
von Meißner, WCG, Strumann, et al |
Rural and remote health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We report and clinically characterize the first cohort of SARS-CoV-2 infected patients in the Black Forest district,
in south-western Germany. Beginning with the first case reported on 4 March, until 24 April 2020, the district observed a period prevalence ratio of 442.6 PCR confirmed cases/100 000 inhabitants to the national health authorities. The most common risk factor
among these 91 patients (median age 44.0 years, 57.1% male) was arterial hypertension, followed by diabetes mellitus, bronchial asthma and chronic heart failure. The most common presenting symptoms were fatigue (84.6%), cough (75.8%), and loss of smell and
taste (71.4%). Between 5 March and 24 April, none of these patients required hospital admission, and no deaths were reported. Elderly patients, often cared for in retirement homes by family physicians, are underrepresented in our sample. |
|
Wadhawan, Anshul |
ArXiv |
Public Health response| Interventions de santé publique |
This paper presents the approach that we employed to tackle the EMNLP WNUT-2020 Shared Task 2 : Identification of informative
COVID-19 English Tweets. The task is to develop a system that automatically identifies whether an English Tweet related to the novel coronavirus (COVID-19) is informative or not. We solve the task in three stages. The first stage involves pre-processing the
dataset by filtering only relevant information. This is followed by experimenting with multiple deep learning models like CNNs, RNNs and Transformer based models. In the last stage, we propose an ensemble of the best model trained on different subsets of the
provided dataset. Our final approach achieved an F1-score of 0.9037 and we were ranked sixth overall with F1-score as the evaluation criteria. |
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Wang, C, Chudzicka-Czupała, et al |
Frontiers in Psychiatry |
Public Health response| Interventions de santé publique |
The physical and mental health of citizens living in a country that encouraged face masks (China) and discouraged face
masks (Poland) during the initial stage of the COVID-19 pandemic remained unknown. We conducted a cross-country study to compare the psychological impact of the COVID-19 pandemic on Poles and Chinese. This study included a total of 2,266 survey respondents
from both countries (1,056 Poles and 1,210 Chinese). There were significantly less Polish respondents who wore face masks (Poles: 35.0%; Chinese: 96.8% p < 0.001). Significantly more Polish respondents reported physical symptoms resembling COVID-19 infection
(p < 0.001), recent medical consultation (p < 0.01), recent COVID-19 testing (p < 0.001), and hospitalization (p < 0.01). Furthermore, Polish respondents had significantly higher levels of anxiety, depression and stress (p < 0.001) than Chinese. Use of face
masks at the community level may safeguard better physical and mental health during the COVID-19 pandemic. |
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Wang, MJ, Schapero, et al |
Am J Perinatol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The study aimed to compare the quantitative blood loss (QBL) and hemorrhage-related outcomes of pregnant women with
and without a coronavirus disease 2019 (COVID-19) diagnosis. This retrospective cohort study of all live deliveries at Boston Medical Center between April 1, 2020 and July 22, 2020 compares the outcomes of pregnant women with a laboratory-confirmed COVID-19
positive diagnosis and pregnant women without COVID-19. The primary outcomes are QBL and obstetric hemorrhage. Of 813 women who delivered a live infant between April 1 and July 22, 2020, 53 women were diagnosed with COVID-19 on admission to the hospital. Women
with a COVID-19 diagnosis at their time of delivery were significantly more likely to identify as a race other than white (p = 0.01), to deliver preterm (p = 0.05), to be diagnosed with preeclampsia with severe features (p < 0.01), and to require general anesthesia
(p < 0.01). Women diagnosed with COVID-19 did not have a significantly higher QBL (p = 0.64). COVID-19 positive pregnant patients had no increased adjusted odds of obstetric hemorrhage (adjusted odds ratio aOR]: 0.41, 95% confidence interval CI]: 0.17-1.04)
and no increased adjusted odds of the maternal morbidity composite (aOR: 0.98, 95% CI: 0.50-1.93) when compared with those without a diagnosis of COVID-19. Pregnant women with COVID-19 diagnosis do not have increased risk for obstetric hemorrhage, increased
QBL or risk of maternal morbidity compared with pregnant women without a COVID-19 diagnosis. |
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Wang, Q, Cao, et al |
Nan Fang Yi Ke Da Xue Xue Bao |
Public Health response| Interventions de santé publique |
During the COVID-19 epidemic, the medical staff divided the patients visiting the emergency department into suspected
group, fever group and control group through interview of the patients at triage. Self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were distributed to each patient, and a trained medical staff was responsible for assisting the patient
to complete the scales. A total of 557 sets of scales were distributed, including 211 in suspected COVID-19 case group, 167 in fever group and 179 in the control group. A total of 516 scales were retrieved, including 197 in suspected case group, 151 in fever
group and 168 in control group. In the 3 groups, the incidence rates of anxiety and depression were 57.87% and 58.88%, 48.34% and 43.71%, and 18.31% and 18.99%, respectively, and the rates were significantly higher in suspected group and fever group than in
the control group (P < 0.01), and significantly higher in suspected group than in fever group (P < 0.05). The standardized anxiety and depression scale scores in suspected case group, fever group and control group were 57.38±16.25 and 42.58±14.27, 51.23±15.29
and 38.32±15.39, and 32.58±17.8 and 12.25±12.94, respectively. Compared with the control group, both suspected case group and fever group had significantly higher standard scores for anxiety and depression (P < 0.01), and suspected case group had significantly
higher standardized scores than fever group (P < 0.01). |
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Anesthesia methods for patients undergoing orthopeadic surgery in the epidemic period
of COVID-19 |
Wang, X, Li, et al |
Chinese Journal of Orthopaedic Trauma |
Healthcare Response | Réponse des soins de santé |
Objective: To compare the anesthesia methods for patients undergoing orthopaedic surgery between the epidemic period
of COVID-19 in 2020 and the same period in 2019. A total of 285 orthopedic operations were completed in the epidemic period in 2020, a decrease by 63.7% than the 784 operations in the same period in 2019; the proportion of elderly fracture patients ≥65 years
old in 2020 29.5%(84/285)] was significantly higher than that 18.1%(142/784)] in 2019. The anesthesia methods for patients undergoing orthopaedic surgery in the epidemic period in 2020 were featured by non-airway management like peripheral nerve block anesthesia,
intraspinal anesthesia, and laryngeal mask/+peripheral nerve block anesthesia because they might have helped to reduce the postoperative complications in respiratory system.The anesthetic operation time in the epidemic period in 2020 was increased than in
the same period in 2019. |
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Impact of COVID-2019 on stroke services in China: survey from the Chinese Stroke Association |
Wang, X, Ouyang, et al |
Stroke Vasc Neurol |
Healthcare Response | Réponse des soins de santé |
We aimed to illustrate how the stroke services were interrupted during the pandemic in China. We found a significant
reduction of admission for all types of patients with stroke during the pandemic. Patients were less likely to receive appropriate care, for example, thrombolysis/thrombectomy, after being admitted to the hospital. Stroke service in severe COVID-19 epidemic
areas, for example, Wuhan, was much more severely impacted compared with other regions in China. |
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Wei, JT, Liu, et al |
Int J Environ Res Public Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Healthcare workers (HCWs) worldwide are putting themselves at high risks of coronavirus disease 2019 (COVID-19) by
treating a large number of patients while lacking protective equipment. We aim to provide a scientific basis for preventing and controlling the COVID-19 infection among HCWs. We used data on COVID-19 cases in the city of Wuhan to compare epidemiological characteristics
between HCWs and non-HCWs and explored the risk factors for infection and deterioration among HCWs based on hospital settings. The attack rate (AR) of HCWs in the hospital can reach up to 11.9% in Wuhan. The time interval from symptom onset to diagnosis in
HCWs and non-HCWs dropped rapidly over time. From mid-January, the median time interval of HCW cases was significantly shorter than in non-HCW cases. Cases of HCWs and non-HCWs both clustered in northwestern urban districts rather than in rural districts.
HCWs working in county-level hospitals in high-risk areas were more vulnerable to COVID-19. HCW cases working in general, ophthalmology, and respiratory departments were prone to deteriorate compared with cases working in the infection department. The AR of
COVID-19 in HCWs are higher than in non-HCWs. Multiple factors in hospital settings may play important roles in the transmission of COVID-19. Effective measures should be enhanced to prevent HCWs from COVID-19 infection. |
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Mucormycosis with orbital compartment syndrome in a patient with COVID-19 |
Werthman-Ehrenreich, A |
American Journal of Emergency Medicine |
Clinical data| Données cliniques |
During the current pandemic of COVID-19, a myriad of manifestations and complications has emerged and are being reported
on. We are discovering patients with COVID-19 are at increased risk of acute cardiac injury, arrythmias, thromboembolic complications (pulmonary embolism and acute stroke), and secondary infection to name a few. I describe a novel case of COVID-19 in a previously
healthy 33-year-old female who presented for altered mental status and proptosis. She was ultimately diagnosed with mucormycosis and orbital compartment syndrome, in addition to COVID-19. Early identification of these high morbidity conditions is key to allow
for optimal treatment and improved outcomes. © 2020 Elsevier Inc. |
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Whittle, J, Molinger, et al |
Crit Care |
Clinical data| Données cliniques |
The LEEP-COVID study (Duke University) aimed to assess the measured resting energy expenditure (mREE) of patients with
severe COVID-19 infection. This letter reported the preliminary results of indirect calorimetry (IC) analysis of REE in 22 intubated patients with COVID-19. During the 1st ICU week, mREE was observed to fall between 15 and 20 kcal/kg (for ABW in BMI < 30
and AdjBW in obese subjects.). Increasing hypermetabolism and wider variability in mREE were observed post-1st ICU week. Unlike data from smaller studies in other ICU populations [1], observed hypermetabolism persisted, and in fact increased during 3rd ICU
week (mean mREE = 150% pREE in 3rd ICU week). |
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Multiple COVID-19 Clusters on a University Campus - North Carolina, August 2020 |
Wilson, E, Donovan, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
On August 3, 2020, university A in North Carolina broadly opened campus for the first time since transitioning to primarily
remote learning in March. Consistent with CDC guidance at that time, steps were taken to prevent the spread of SARS-CoV-2 on campus. During August 3-25, 670 laboratory-confirmed cases of COVID-19 were identified; 96% were among patients aged <22 years. Eighteen
clusters of five or more epidemiologically linked cases within 14 days of one another were reported; 30% of cases were linked to a cluster. Student gatherings and congregate living settings, both on and off campus, likely contributed to the rapid spread of
COVID-19 within the university community. On August 19, all university A classes transitioned to online, and additional mitigation efforts were implemented. At this point, 334 university A-associated COVID-19 cases had been reported to the local health department. |
|
Wong, SYS, Zhang, et al |
Br J Gen Pract |
Public Health response| Interventions de santé publique |
Mental health and health service utilisation outcomes were compared with the outcomes before the onset of the COVID-19
outbreak in Hong Kong. Data were collected via telephone survey from 583 older (≥60 years) adults. There were significant increases in loneliness, anxiety, and insomnia, after the onset of the COVID-19 outbreak. Missed medical appointments over a 3-month period
increased from 16.5% 1 year ago to 22.0% after the onset of the outbreak. In adjusted analysis, being female, living alone, and having >4 chronic conditions were independently associated with increased loneliness. Females were more likely to have increased
anxiety and insomnia. |
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Xia, Y, Kou, et al |
Sleep medicine |
Public Health response| Interventions de santé publique |
We conducted a quantitative study, which included 119 Chinese Parkinson's disease (PD) patients who had been treated
in an outpatient neurology clinic in Wuhan and 169 age- and sex-matched healthy controls. The questionnaire survey focused on the impact of the COVID-19 pandemic on sleep, mental status, symptoms, and daily life and medical treatment of PD patients. Compared
to healthy controls, PD patients had significantly higher scores in the Pittsburgh Sleep Quality Index (PSQI) (8.13 vs 5.36, p 5 points (68.9% vs 44.4%, p < 0.001). Sleep disturbance was identified in 68.9% of PD patients and was independently associated with
exacerbation of PD symptoms (OR = 3.616, 95%CI= (1.479, 8.844), p = 0.005) and anxiety (OR = 1.379, 95%CI= (1.157, 1.642), p < 0.001). Compared to male PD patients, female ones had higher PSQI scores (9.28 ± 4.41 vs 7.03 ± 4.01, p = 0.009) and anxiety (32.8%
vs 0.1%, p = 0.002) and depression prevalence (34.5% vs 11.5%, p = 0.003). |
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Xu, Y, Lu, et al |
Chinese Journal of Orthopaedic Trauma |
Healthcare Response | Réponse des soins de santé |
A retrospective analysis was conducted of the 88 patients with 97 lower extremity fractures who had been admitted to
Department of Orthopedic Trauma, Honghui Hospital Affiliated to Xi'an Jiaotong University College of Medicine from 23rd January, 2020 to 22nd February, 2020. The patients underwent screening for COVID-19 infection before admission. All the 88 patients were
COVID-19 negative in the screening before admission. The time from injury to admission averaged 4.5 days, the time from admission to surgery 3.7 days and hospital stay 6.6 days. The prostheses were all well located in the 28 patients undergoing hip replacement.
The rate of functional and anatomic reduction was 94.2%(65/69) in the 69 patients undergoing internal fixation. Peri-operatively, DVT occurred in 25 cases (28.4%). High temperature was observed in 7 patients within 3 days after operation, which was diagnosed
as absorption fever. No medical staff or patients were infected by COVID-19. |
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Yamada, M, Rastogi, et al |
Transplantation proceedings |
Clinical data| Données cliniques |
Kidney injury is a well-known complication in people with coronavirus disease 2019 (COVID-19). In kidney transplant
recipients with COVID-19, presentation with nephrotic syndrome has not been well described. We report on a 49-year-old black female kidney transplant recipient who presented 25 years after transplant with clinical features of nephrotic syndrome following a
diagnosis of COVID-19. Histologic examination showed acute tubular injury with unremarkable glomeruli on light microscopy and diffuse foot process effacement of podocytes on electron microscopy, consistent with minimal change–like podocyte injury. Apolipoprotein
L1 (APOL1) genetic testing confirmed 2 high-risk APOL1 alleles in the kidney donor. We speculate that COVID-19–induced systemic or local cytokine release could serve as a second hit in the presence of APOL1 risk alleles and mediate a podocytopathy manifesting
as nephrotic syndrome. The presented case with minimal change–like disease, occurring in the context of the donor high-risk APOL1 genotype, extends the spectrum of clinical manifestations in COVID-19–associated nephropathy. |
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Yang, J, Wang, et al |
Mathematical Modelling of Natural Phenomena |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The study utilized Markov chain Monte Carlo (MCMC) algorithm and contact matrixes to describe the contact heterogeneities
and correlations among different age groups. Through a more in-depth study, we showed that before January 28th (95% CI [Feb. 25th, Feb. 31st]), it was estimated that the peak values of infection were 66 (95% CI [65,67]) for the adolescents, 3996 (95% CI [3957,4036])
for the young group, 14714 (95% CI [14692,14735]) for middle-aged group and 297 (95% CI [295,300]) for elderly people, respectively; the proportions of the final sizes of SARS-COV-2 infection accounted for less than 90% for each group. The most severe and
high-risk group was middle-aged people aged between 50–74 yr old; without any prevention, the most severe and high-risk group had become the young adults aged 20–49 yr old. |
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Prediction of COVID-19 spread via LSTM and the deterministic SEIR model |
Yang, Y, Yu, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Due to the outbreak of COVID-19, China and most countries in the world have been seriously affected and tens of thousands
of people have lost their lives, it is urgent to study the transmission characteristics and trends of the virus. In this study, we adopt the Long Short Term Memory algorithm at first to predict the infected population in China. However, it does not explain
the dynamics of diffusion process, and the long-term prediction error is too large. Therefore, the widely-accepted SEIR model is introduced to capture the spread process of COVID-19. By using a sliding window method, we suggest that the parameter estimation
and the prediction of the infected populations are well performed. This may provide some insights for epidemiological studies and understanding of the spread of the current COVID-19. © 2020 Technical Committee on Control Theory, Chinese Association of Automation. |
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Evaluation of the novel coronavirus disease in Turkish Children; Preliminary Outcomes |
Yılmaz, K, Gozupirinççioğlu, et al |
Pediatr Pulmonol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to investigate the disease features of Covid‐19 in Turkish children. Children diagnosed by
the method of RT‐PCR for Covid‐19 at the Dicle University Department of Pediatric, between April and June 2020, were evaluated. Hospital records were investigated retrospectively. One hundred and five patients children with the mean age of 108.64±65.61 months
were enrolled in this study. The most common cause of transmission in pediatric patients was contact with a family member diagnosed with COVID‐19 (n=91, 86.7%).The most common admission complaints were dry cough (n=17, 16.2%), fever (n=16, 15.2%), lassitude
and fatigue (n=14, 13.3%) respectively. More than 95 % of all children with Covid‐19 were asymptomatic, mild, or moderate cases. CRP was identified only independent factor associated with long duration of hospitalization. |
|
Yin, L, Gao, et al |
Comb Chem High Throughput Screen |
Therapeutics| Thérapeutique Healthcare Response | Réponse des soins de santé |
The aim of this study was to analyze the Traditional Chinese medicine (TCM) prescription pattern in Regional Schemes
in China for COVID-19 in order to provide a new reference for the use of TCM in COVID-19 treatment. TCM syndromes and herbal medicines were analyzed by data mining in 23 Regional Schemes. The Ancient and Modern Medical Case Cloud Platform (V2.1 personal Edition)
was utilized and found a total of 82 TCM syndromes and 171 Chinese herbal medicines. The course of the disease can be divided into the early stage, middle stage, severe stage, and recovery stage. The effectiveness of these 171 Chinese herbs include but are
not limited to inhibiting COVID-19, strengthening immune system function, preventing heart failure, acting as antioxidants, oxidative stress inhibitory effects, maintaining organ function, and improving leukocyte survival. |
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Urban Vegetation Slows Down the Spread of Coronavirus Disease (COVID-19) in the United States |
You, Y, Pan, et al |
Geophysical Research Letters |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Coronavirus Disease 2019 (COVID-19) is spreading around the world, and the United States has become the epicenter of
the global pandemic. However, little is known about the causes behind the large spatial variability of the COVID-19 incidence. Here we use path analysis model to quantify the influence of four potential factors (urban vegetation, population density, air temperature,
and baseline infection) in shaping the highly heterogeneous transmission patterns of COVID-19 across the United States. Our results show that urban vegetation can slow down the spread of COVID-19, and each 1% increase in the percentage of urban vegetation
will lead to a 2.6% decrease in cumulative COVID-19 cases. Additionally, the mediating role of urban vegetation suggests that urban vegetation could reduce increases in cumulative COVID-19 cases induced by population density and baseline infection. Our findings
highlight the importance of urban vegetation in strengthening urban resilience to public health emergencies. ©2020. The Authors. |
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Yousaf, MA, Noreen, et al |
Social Work in Public Health |
Public Health response| Interventions de santé publique |
We conducted the current study to assess KAP among the general population of Jammu and Kashmir (J&K), India, based
on an online cross-sectional survey. Participants completed a questionnaire we developed consisting of KAP questions. We also collected sociodemographic information and source of information about disease awareness. The main source of information regarding
COVID-19 was Internet social media (66.3%) followed by TV (17.4%). We conducted nonparametric analyses on KAP scores using a Mann–Whitney U and Kruskall–Wallis H tests (P < .05) to find out the association with sociodemographic characteristics. The overall
knowledge score (correct answer) was 88.9%, which was significantly associated with gender, age, qualification, and occupation. The positive attitude score was 73.3%, which was significantly associated with gender, age, qualification, marital status, and geographic
area. Overall, 93.0% positive practices were observed in the general population based on asked questions. |
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Zafar, N, Jamal, et al |
Frontiers in Public Health |
Healthcare Response | Réponse des soins de santé |
This study is focused on assessing the preparedness of healthcare personnel and the effectiveness of an educational
intervention to improve this preparedness in those dealing with the COVID-19 infection. A prospective, multicenter audit cycle was conducted on 400 healthcare professionals (271 junior doctors, 90 nurses, 39 non-clinical hospital workers) sampled through stratified
random sampling. In the pre-intervention portion of the study, it was found out that the doctors and nurses had higher knowledge scores compared to the non-clinical hospital staff (p ≤ 0.05). A statistically significant improvement was seen after the educational
intervention was deployed (p ≤ 0.05). |
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Zazzara, MB, Penfold, et al |
Age Ageing |
Clinical data| Données cliniques |
OBJECTIVE: To assess how frailty affects presenting COVID-19 symptoms in older adults. SUBJECTS: Hospital cohort: patients
aged 65 and over (n = 322); unscheduled hospital admission between March 1st, 2020-May 5th, 2020; COVID-19 confirmed by RT-PCR of nasopharyngeal swab. Community-based cohort: participants aged 65 and over enrolled in the COVID Symptom Study (n = 535); reported
test-positive for COVID-19 from March 24th (application launch)-May 8th, 2020. |
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Zhang, LL, Liu, et al |
Turk J Haematol |
Clinical data| Données cliniques |
A 46-year-old female patient presented with diarrhea, a cough with clear sputum, and fatigue for 3 days. The RT-PCR
assay of throat swab was positive for SARS-CoV-2 infection, consistant with CT findings.The patient developed worsening hypoxemia , with oxyhemoglobin saturation (SaO2) oscillating between 90% and 93%, after receiving conventional antiviral therapy, such as
arbidol (200 mg three times daily), oseltamivir (75 mg twice daily), ribavirin (500 mg every 12 hours), and interferon-alpha-2b inhalation (5 million units twice daily). This was followed by transfusion. This pilot study on CP therapy shows it can serve as
a promising rescue option for hematologic cancer patients with severe COVID-19, which warrants further investigation by randomized trials. |
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Zhang, Ming, Jin, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
This is a multicentre, retrospective, cohort study, of 5,235 adult patients who were admitted to 3 hospitals in Wuhan,
China with confirmed COVID-19. Univariable and multivariable Logistic and Cox regression models showed that follow-up patients of non-tocilizumab group were more likely to develop into death (42 [32·31%] vs 14 [21·54%]). The detected risk for in-hospital death
was lower in the tocilizumab group versus the non-tocilizumab group (HR=0·47; 95% CI=0·25-0·90; p=0·023). In the multivariable logistic regression model, use of tocilizumab was associated with a lower risk of ARDS (OR=0 · 23; 95% CI=0·11-0·45; p<0·0001). Tocilizumab
may be of value in improving outcomes in severe patients of COVID-19, which provided a novel strategy for COVID-19-induced cytokine release syndrome (CRS). |
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Characteristics and management of emergency patients with orthopedic trauma during COVID-19
epidemic |
Zhang, P, Wang, et al |
Chinese Journal of Orthopaedic Trauma |
Healthcare Response | Réponse des soins de santé |
Objective: To investigate the characteristics and management of the emergency patients with orthopaedic trauma during
COVID-19 epidemic. Methods: A retrospective analysis was performed of the 32 emergency inpatients at Department of Orthopedics, Nanfang Hospital from January 20 to February 26, 2020. They were 23 males and 9 females, aged from 4 to 66 years (mean, 35 years).
The causes for their injury included traffic accident in 14 cases, sharp cutting (e.g. by a kitchen knife) in 6 cases, heavy object crushing in one, machine crushing in one, fall in 2, and machine twisting in one. High energy injury occurred in 13 cases and
low-energy injury in 9 cases. The injury involved the upper limb in 7 cases and the lower limb in 15 cases. Grade
Ⅱ protection was adopted during the diagnosis and treatment for the
one emergency patient who had not undergone nucleic acid screening for 2019-nCoV while grade
Ⅰ protection for the other 21 patients. 2019-nCoV infection was recorded
in the patients and medical staff as well. The measures and experience were reviewed in the management of orthopaedic emergencies during the COVID-19 epidemic. Results: During the diagnosis and treatment of 22 emergency patients with orthopaedic trauma, none
of the medical staff or patients was infected with COVID-19. As the one emergency patient was treated as a suspected case and protected by grade
Ⅱ measures, COVID-19 infection was ruled out after surgery. Conclusions:
During the COVID-19 epidemic, front-line medical staff dealing with traumatic emergencies faced a higher risk of infection. The emergency orthopaedic traumas were mainly caused by a traffic accident or a machine, and those in the elderly patients by a sharp
cutting or a fall. The incidence of COVID-19 infection could be reduced by COVID-19 screening before admission, appropriate anesthesia and surgical methods, protection of perioperative medical staff, postoperative wards care and psychological counseling. Copyright
© 2020 by the Chinese Medical Association. |
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Zhang, Y, Wang, et al |
Journal of psychosomatic research |
Public Health response| Interventions de santé publique |
In this study, the authors conducted a multicenter cross-sectional survey in Shandong Province, China, using quota
sampling combined with snowball sampling to study effect of COVID-19 outbreak. The Generalized Anxiety Disorder-7 (GAD-7), the Patient Health Questionnaire-9 (PHQ-9), and the Insomnia Severity Index (ISI) were used to assess the anxiety, depression, and insomnia
symptoms. A total of 4000 invitations were sent from three centers, 3237 valid questionnaires were received. Based on GAD-7, PHQ-9, and ISI scales, 19.5%–21.7% of the participants had anxiety, depression, or insomnia symptoms; 2.9%–5.6% had severe symptoms.
Besides, 2.4%, 4.8%, and 4.5% of the participants had anxiety-depression, anxiety-insomnia, or depression-insomnia combined symptoms. During the epidemic, 17.4% of the participants had received psychological interventions, and only 5.2% had received individual
interventions. The incidence of psychological distress increased during the outbreak of COVID-19 in the work resumption period than the normal period. Current psychological interventions were insufficient; target psychological interventions should be conducted
in time. |
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Zhao, J, Tian, et al |
Phytomedicine |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
A systems pharmacology strategy was proposed to investigate the mechanisms of QFPDD against COVID-19 from molecule,
pathway and network levels. The approach consisted of text mining, target prediction, data integration, network study, bioinformatics analysis, molecular docking, and pharmacological validation. 623 high-confidence targets of QFPDD's 12 active compounds were
identified, 88 of which were overlapped with genes affected by SARS-CoV-2 infection. Comprehensive network and pathway analysis were used to identify 55 important targets, which regulated 5 functional modules corresponding to QFPDD's effects in immune regulation,
anti-infection, anti-inflammation, and multi-organ protection, respectively. Four compounds (baicalin, glycyrrhizic acid, hesperidin, and hyperoside) and 7 targets (AKT1, TNF-α, IL6, PTGS2, HMOX1, IL10, and TP53) were key molecules related to QFPDD's effects.
Molecular docking verified that QFPDD's compounds may bind to 6 host proteins that interact with SARS-CoV-2 proteins, further supported the anti-virus effect of QFPDD. At last, in intro experiments validated QFPDD's important effects, including the inhibition
of IL6, CCL2, TNF-α, NF-κB, PTGS1/2, CYP1A1, CYP3A4 activity, the up-regulation of IL10 expression, and repressing platelet aggregation. This work illustrated that QFPDD could exhibit immune regulation, anti-infection, anti-inflammation, and multi-organ protection.
It may strengthen the understanding of QFPDD and facilitate more application of this formula in the campaign to SARS-CoV-2. |
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Zhao, Jun, Jaffe, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Traditional cell clustering analysis used to compare the transcriptomic landscapes between two biological states in
single cell RNA sequencing (scRNA-seq) is largely inadequate to functionally identify distinct and important differentially abundant (DA) subpopulations between groups. This problem is exacerbated further when using unsupervised clustering approaches where
differences are not observed in clear cluster structure and therefore many important differences between two biological states go entirely unseen. Here, we develop DA-seq, a powerful unbiased, multiscale algorithm that uniquely detects and decodes novel DA
subpopulations not restricted to well separated clusters or known cell types. We apply DA-seq to several publicly available scRNA-seq datasets on various biological systems to detect differences between distinct phenotype in COVID-19 cases, melanomas subjected
to immune checkpoint therapy, embryonic development and aging brain, as well as simulated data. Importantly, we find that DA-seq not only recovers the DA cell types as discovered in the original studies, but also reveals new DA subpopulations that were not
described before. Analysis of these novel subpopulations yields new biological insights that would otherwise be neglected.Competing Interest StatementThe authors have declared no competing interest. |
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The Relationship Between Chest Imaging Findings and the Viral Load of COVID-19 |
Zhao, W, He, et al |
Frontiers in Medicine |
Clinical data| Données cliniques |
This retrospective study analyzed 56 COVID-19 cases from two institutions in Hunan province, China in order to investigate
the relationship between clinical characteristics, radiographic features, and the viral load of patients with coronavirus disease 2019 (COVID-19). GGO (48, 85.7%) and vascular enlargement (44, 78.6%) were the most frequent signs in COVID-19 patients. The uneasily
differentiated margin was negatively correlated with the Ct value (r = −0.283, P = 0.042), that is, an uneasily differentiated margin indicated a lower Ct value (P = 0.043). The Ct value at baseline could predict a progress follow-up change with an AUC of
0.685 (Cut-off value = 29.48). All four patients with normal CT findings presented new lesion(s) on follow-up CT scans. The viral load of COVID-19 is negatively correlated with an uneasily differentiated lesion margin on initial CT scan images and the Ct value
should noted when making a diagnosis. In addition, following-up CT scans are necessary for patients who presented a normal CT at the initial diagnosis, especially for those with a low Ct value. |
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Zhao, Y, He, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The COVID-19 epidemic has caused great disruption to people's life in China as well as around the world. By using accurate
and effective models to predict the development of the epidemic, authorities can better mitigate the disruption and prepare the people for the outbreak. This paper constructs a SEIQR model with a time-varying parameter that describes the declining reproduction
rate. The model predicts a result of 24,318 (95% CI 13312-41054) confirmed cases in Wuhan before the lockdown, and a peak of daily increase in late February as the total confirmed cases reaches 63,315 (95% CI 28724-117566). The model further combines the prediction
with a network migration model to analyze the risk of outbreak crosses the nation. © 2020 Technical Committee on Control Theory, Chinese Association of Automation. |
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Zhu, L, Shu, et al |
Cardiorenal Med |
Clinical data| Données cliniques |
With the global spread of SARS-Cov-2 infections, increasing numbers of COVID-19 cases have been reported in transplant
recipients. However, reports are lacking concerning the treatment and prognosis of COVID-19 pneumonia in renal transplant recipients with acute cardiorenal syndrome. We report here the complete clinical course of a renal transplant recipient with critical
COVID-19 pneumonia. In the early phase of SARS-Cov-2 infection, the patient exhibited extensive lung lesions and significant acute kidney and heart injuries, which required treatment in the ICU. After correcting the arrhythmia and heart failure, the patient
recovered quickly from the acute kidney injury with a treatment of intensive diuresis and strict control of fluid intake. Without cessation of oral immunosuppressive agents, the patient presented a delayed and low antibody response against SARS-Cov-2 and reappeared
positive for the virus twice after being discharged. Nevertheless, the patient's pneumonia continued to improve and he fully recovered in 69 days. This effectively treated case may be meaningful and referable for the treatment of COVID-19 pneumonia in other
transplant recipients with acute cardiorenal syndrome. |
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Abdelmoneim H, Abdelrahman, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
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Comparative Review of SARS-CoV-2, SARS-CoV, MERS-CoV, and Influenza A Respiratory Viruses |
Abdelrahman, Z, Li, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Abidin, C, Lee, et al |
Media International Australia |
Review Literature| Revue de littérature |
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Abrams, JY, Godfred-Cato, et al |
Journal of Pediatrics |
Review Literature| Revue de littérature |
SR: MIS-C study metadata were assessed and information on case demographics, clinical symptoms, laboratory measurements,
treatments, and outcomes were summarized and contrasted between studies. Eight studies were identified representing a total of 440 MIS-C cases. Inclusion criteria varied by study: 3 studies selected patients diagnosed with Kawasaki disease, 2 required cardiovascular
involvement, and 3 had broader multisystem inclusion criteria. Median age of patients by study ranged from 7.3 to 10 years, and 59% of patients were male. Across all studies, the proportion of patients with positive results for severe acute respiratory syndrome
coronavirus 2 reverse transcriptase-polymerase chain reaction tests ranged from 13% to 69% and for serology, from 75% to 100%. Patients with MIS-C had high prevalence of gastrointestinal (87%), dermatologic/mucocutaneous (73%), and cardiovascular (71%) symptoms.
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Management of Urticaria in COVID-19 Patients: A Systematic Review |
Abuelgasim, E, Dona, et al |
Dermatol Ther |
Review Literature| Revue de littérature |
SR: There is now emerging evidence in of patients experiencing urticaria. All studies were case reports, reporting
26 patients with urticaria and/or angioedema and COVID-19 infection and their management and/or response. Majority of patients (n=16, 69%) were over 50 years old. However, urticaria in the younger ages was not uncommon, with reported case of 2 months old infant.
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Adhit, KK, Anjankar Ashish, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Agrawal, D, Jaiswal, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Agrawal, D, Khara, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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An overview on flavonoids as potential antiviral strategies against coronavirus infections |
Akça, KT, Süntar, et al |
Gazi Medical Journal |
Review Literature| Revue de littérature |
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Akhigbe, R, Hamed, et al |
Asian Pacific Journal of Reproduction |
Review Literature| Revue de littérature |
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Potential Therapeutic Benefits of Dipyridamole in COVID-19 Patients |
Aliter, KF, Al-Horani, et al |
Curr Pharm Des |
Review Literature| Revue de littérature |
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32925133; A review of studies on the COVID-19 epidemic crisis disease with a preventive approach |
Arefi, MF, Poursadeqiyan, et al |
Work (Reading, Mass.) |
Review Literature| Revue de littérature |
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Diagnosis of SARS-CoV-2 infection in the setting of cytokine release syndrome |
Azar, MM, Shin, et al |
Expert Rev Mol Diagn |
Review Literature| Revue de littérature |
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Bahrami, R, Hashemi, et al |
Bratislavske lekarske listy |
Review Literature| Revue de littérature |
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Beltrán-García, J, Osca-Verdegal, et al |
Antioxidants (Basel) |
Review Literature| Revue de littérature |
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Bertoli, F, Veritti, et al |
Journal of Ophthalmology |
Review Literature| Revue de littérature |
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Bhokardankar, P, Rathi, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Bhutada, RS, Rathi, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Management of complicated pediatric rhinosinusitis in the COVID-19 era |
Blanco, CH, Stein, et al |
American Journal of Otolaryngology - Head and Neck Medicine and Surgery |
Review Literature| Revue de littérature |
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Bonkowsky, JL, deVeber, et al |
Pediatric neurology |
Review Literature| Revue de littérature |
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Cereda, E, Bogliolo, et al |
Curr Opin Clin Nutr Metab Care |
Review Literature| Revue de littérature |
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Cheng, W, Li, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
SR-MA: evaluate the efficacy and safety of corticosteroid therapy in patients with COVID-19. Eleven cohort studies
(corticosteroid group vs control group), two retrospective cohort studies (without control group), and seven case studies were identified. A total of 2840 patients were included. Compared with the control treatments, corticosteroid therapy was associated with
clinical recovery (RR = 1.30, 95% CI 0.98, 1.72]) and a significantly shortened length of ICU hospitalization (RR = −6.50; 95% CI −7.63 to −5.37]), but it did not affect the mortality ((RR = 1.59; 95% CI 0.69–3.66], I2 = 93.5%), utilization of mechanical ventilation
(RR = 0.35; 95% CI 0.10, 1.18]), duration of symptoms (WMD = 1.69; 95% CI −0.24 to 3.62]) or virus clearance time (RR = 1.01; 95% CI −0.91 to 2.92], I2 = 57%) in COVID-19 patients. Treatment with corticosteroids in patients with COVID-19 may cause mild adverse
outcomes. The quality of evidence was low or very low for all outcomes. |
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Systematic Review of Ocular Involvement of SARS-CoV-2 in Coronavirus Disease 2019 |
Cheong, KX |
Current Ophthalmology Reports |
Review Literature| Revue de littérature |
SR: summarise and discuss the current literature regarding ocular involvement of SARS-CoV-2 in COVID-19. In this systematic
review, the prevalence of ocular symptoms and signs was low (from 0 to 31.58%) and conjunctivitis was a relatively rare occurrence. The rate of detection of SARS-CoV-2 in the ocular swab samples was low as well and this ranged from 0 to 11.11%.
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Rapid review of early status of COVID-19 infection in South Korea |
Choi, M, Shin, et al |
Journal of the Korean Medical Association |
Review Literature| Revue de littérature |
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Consolo, U, Bencivenni, et al |
Dental Cadmos |
Review Literature| Revue de littérature |
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Potential statin drug interactions in elderly patients: a review |
Damiani, I, Corsini, et al |
Expert Opin Drug Metab Toxicol |
Review Literature| Revue de littérature |
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Darwate, T, Hiware, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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De Sire, A, Andrenelli, et al |
Eur J Phys Rehabil Med |
Review Literature| Revue de littérature |
SR: second edition of the Cochrane Rehabilitation 2020 rapid living systematic review. Thirty-two studies (62.7%)
included COVID-19 patients who were assessed in the acute (20/32) or post-acute phases (12/32). The other studies reported data on the impact of COVID-19 infection (7/19) or on the effect of lockdown restrictions (12/19) on subjects with pre-existing health
conditions. CONCLUSIONS: The scientific literature of August 2020 mainly focused on limitations in functioning of nervous system structure and related functions. Albeit the increased availability of data from analytical studies (both cohort and cross-sectional),
there is still a lack of well-.conductedLevel 2 studies, to improve the knowledge on the effects of rehabilitation in COVID-19 patients. |
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Dhakite, S, Wajpeyi, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Coagulopathy, Venous Thromboembolism, and Anticoagulation in Patients with COVID-19 |
Dobesh, PP, Trujillo, et al |
Pharmacotherapy |
Review Literature| Revue de littérature |
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Shipping and COVID-19: protecting seafarers as frontline workers |
Doumbia-Henry, C |
WMU Journal of Maritime Affairs |
Review Literature| Revue de littérature |
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Application of carbon nanomaterials in human virus detection |
Ehtesabi, H |
Journal of Science: Advanced Materials and Devices |
Review Literature| Revue de littérature |
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Emanuelli, G, Nassehzadeh-Tabriz, et al |
Eur Respir Rev |
Review Literature| Revue de littérature |
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Fernandez, R, Lord, et al |
Int J Nurs Stud |
Review Literature| Revue de littérature |
SR: To synthesize and present the best available evidence on the experiences of nurses working in acute hospital settings
during a pandemic. Thirteen qualitative studies were included in the review. The experiences of 348 nurses generated a total of 116 findings, which formed seven categories based on similarity of meaning. Three synthesized findings were generated from the categories:
(i) Supportive nursing teams providing quality care; (ii) Acknowledging the physical and emotional impact; and (iii) Responsiveness of systematised organizational reaction.
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Figueiro-Filho, E, Yudin, et al |
J Perinat Med |
Review Literature| Revue de littérature |
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Ghasemiyeh, P, Mohammadi-Samani, et al |
Heart and Lung |
Review Literature| Revue de littérature |
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González-Méijome, JM |
J Optom |
Review Literature| Revue de littérature |
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The use of mobile phone data to inform analysis of COVID-19 pandemic epidemiology |
Grantz, KH, Meredith, et al |
Nat Commun |
Review Literature| Revue de littérature |
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Gyanwali, P, Sharma, et al |
Journal of Nepal Health Research Council |
Review Literature| Revue de littérature |
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An overview of vitamins and minerals in the prevention of COVID-19 infection |
Hacışevki, A, Baba, et al |
Gazi Medical Journal |
Review Literature| Revue de littérature |
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PMC7427517; Dear and Glorious Physician, who are we in COVID-19? |
Herrera, B, Vinck, et al |
Ethics Med Public Health |
Review Literature| Revue de littérature |
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Hooper, NM, Lambert, et al |
Clin Sci (Lond) |
Review Literature| Revue de littérature |
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Hoover, AG, Heiger-Bernays, et al |
Rev Environ Health |
Review Literature| Revue de littérature |
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Hosseini-Zare, M, Thilagavathi, et al |
RSC Advances |
Review Literature| Revue de littérature |
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Obesity in patients with COVID-19: a systematic review and meta-analysis |
Huang, Y, Yao, et al |
Metabolism |
Review Literature| Revue de littérature |
SR: This study explores the effects of obesity with the risk of severe disease among patients with COVID-19. A total
of 45, 650 participants from 30 studies with BMI-defined obesity and 3 controlled studies with VAT-defined adiposity were included for assessing the risk of severe COVID-19. Univariate analyses showed significantly higher ORs of severe COVID-19 with higher
BMI: 1.76 (95%: 1.21, 2.56, P = 0.003) for hospitalization, 1.67 (95%CI: 1.26, 2.21, P<0.001) for ICU admission, 2.19 (95%CI: 1.56, 3.07, P<0.001) for IMV requirement, and 1.37 (95%CI: 1.06, 1.75, P = 0.014) for death, giving an overall OR for severe COVID-19
of 1.67 (95%CI: 1.43, 1.96; P<0.001). Multivariate analyses revealed increased ORs of severe COVID-19 associated with higher BMI: 2.36 (95%CI: 1.37, 4.07, P = 0.002) for hospitalization, 2.32 (95%CI: 1.38, 3.90, P = 0.001) for requiring ICU admission, 2.63
(95%CI: 1.32, 5.25, P = 0.006) for IMV support, and 1.49 (95%CI: 1.20, 1.85, P<0.001) for mortality, giving an overall OR for severe COVID-19 of 2.09 (95%CI: 1.67, 2.62; P<0.001). Compared to non-severe COVID-19 patients, severe COVID-19 cases showed significantly
higher VAT accumulation with a SMD of 0.49 for hospitalization (95% CI: 0.11, 0.87; P = 0.011), 0.57 (95% CI: 0.33, 0.81; P<0.001) for requiring ICU admission and 0.37 (95% CI: 0.03, 0.71; P = 0.035) for IMV support. The overall SMD for severe COVID-19 was
0.50 (95% CI: 0.33, 0.68; P<0.001). |
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Huang, YW, Tsai, et al |
Dermatologica Sinica |
Review Literature| Revue de littérature |
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Domestic violence in the coronavirus disease 2019 era: Insights from a survivor |
Hudson, LC, Lowenstein, et al |
Clinics in dermatology |
Review Literature| Revue de littérature |
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Hung, IFN |
Curr Opin HIV AIDS |
Review Literature| Revue de littérature |
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Jänig, C, Forklage, et al |
Mil Med |
Review Literature| Revue de littérature |
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Cancer and Coronavirus Disease (COVID-19): Comorbidity, Mechanical Ventilation, and Death Risk |
Jarahzadeh, MH, Asadian, et al |
J Gastrointest Cancer |
Review Literature| Revue de littérature |
SR: . In this study, we reviewed cancer comorbidity and risk of mechanical ventilation or death in patients with confirmed
COVID-19. A total of 12 cohort studies exclusively on cancer patients with confirmed COVID-19 were selected. CONCLUSIONS: According to the findings of this study, cancer was not among the most prevalent underlying diseases in patients with confirmed COVID-19.
Moreover, cancer patients infected with COVID-19 had the lowest risk of mechanical ventilation or death than the non-cancer infected patients. |
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Neurological consequences of COVID-19: what have we learned and where do we go from here? |
Jarrahi, A, Ahluwalia, et al |
J Neuroinflammation |
Review Literature| Revue de littérature |
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Covid-19 school closures: Implications for pediatric diabetes management-a commentary |
Jaswaney, R, Cerdeña, et al |
Health Behavior and Policy Review |
Review Literature| Revue de littérature |
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Leveraging Computational Modeling to Understand Infectious Diseases |
Jenner, AL, Aogo, et al |
Current Pathobiology Reports |
Review Literature| Revue de littérature |
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Alternative medicine suggestions for treatment of COVID-19-a review |
Jeyashree, T, Somasundaram, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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José, RJ, Williams, et al |
Eur Respir Rev |
Review Literature| Revue de littérature |
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Effective Immune Functions of Micronutrients against SARS-CoV-2 |
Junaid, K, Ejaz, et al |
Nutrients |
Review Literature| Revue de littérature |
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Kalli, JR, Raj, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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The impact of ACE2 gene polymorphism in the development of COVID-19 disease |
Karahalil, B, Elkama, et al |
Gazi Medical Journal |
Review Literature| Revue de littérature |
In this study, the distribution of ACE2 gene polymorphism and infected cases were presented in 6 populations all over
the world and the related evaluations were made. Studies should be made to find out responsible factor for these different responses to disease, the associations between gene polymorphisms of other proteins on immune system and development of COVID-19 disease. |
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Kavitha, C, Madhavaprasad, et al |
Disaster Advances |
Review Literature| Revue de littérature |
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The relevance of dietetic approach of ayurveda from the perspective of COVID-19 pandemic |
Khabade, S, Rathi, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Artificial intelligence in pulmonary medicine: computer vision, predictive model and COVID-19 |
Khemasuwan, D, Sorensen, et al |
Eur Respir Rev |
Review Literature| Revue de littérature |
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Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle
loss |
Kirwan, R, McCullough, et al |
Geroscience |
Review Literature| Revue de littérature |
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Klaritsch, P, Ciresa-König, et al |
Geburtshilfe und Frauenheilkunde |
Review Literature| Revue de littérature |
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Kumari, PL, Shalini, et al |
Disaster Advances |
Review Literature| Revue de littérature |
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Lal, A, Ashworth, et al |
Disaster Med Public Health Prep |
Review Literature| Revue de littérature |
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Lamb, CR, Desai, et al |
Chest |
Review Literature| Revue de littérature |
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Challenges to the Emergence of Telerehabilitation in a Developing Country: A Systematic Review |
Leochico, CFD, Espiritu, et al |
Frontiers in Neurology |
Review Literature| Revue de littérature |
SR challenges faced by telerehabilitation in the Philippines.
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The Coronavirus Disease 2019 pandemic: how does it spread and how do we stop it? |
Li, X, Sridhar, et al |
Curr Opin HIV AIDS |
Review Literature| Revue de littérature |
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Liao, WT, Hsu, et al |
Adv Biosyst |
Review Literature| Revue de littérature |
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Lim, MA, Pranata, et al |
Journal of Clinical Orthopaedics and Trauma |
Review Literature| Revue de littérature |
SR evaluate the prevalence of coronavirus disease 2019 (COVID-19) and its impact on mortality in patients with hip
fracture. |
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Unraveling the Possible Routes of SARS-COV-2 Invasion into the Central Nervous System |
Lima, M, Siokas, et al |
Current Treatment Options in Neurology |
Review Literature| Revue de littérature |
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Liu, JM, Tan, et al |
J Med Virol |
Review Literature| Revue de littérature |
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BCG vaccine: a hope to control COVID-19 pandemic amid crisis |
Malik, YS, Ansari, et al |
Hum Vaccin Immunother |
Review Literature| Revue de littérature |
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Manuballa, S, Abdelmaseh, et al |
J Clin Med |
Review Literature| Revue de littérature |
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Markeson, D, Freeman Romilly, et al |
Journal of Plastic, Reconstructive and Aesthetic Surgery |
Review Literature| Revue de littérature |
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Frontiers of Robotic Gastroscopy: A Comprehensive Review of Robotic Gastroscopes and Technologies |
Marlicz, W, Ren, et al |
Cancers (Basel) |
Review Literature| Revue de littérature |
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Investigation on the human coronaviruses origin (Bats and pangolins): A review |
Mawolo, JB, Akiti, et al |
Turkish Journal of Zoology |
Review Literature| Revue de littérature |
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Targeting the SphK-S1P-SIPR Pathway as a Potential Therapeutic Approach for COVID-19 |
McGowan, EM, Haddadi, et al |
Int J Mol Sci |
Review Literature| Revue de littérature |
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Digital phenotyping for mental health of college students: a clinical review |
Melcher, J, Hays, et al |
Evid Based Ment Health |
Review Literature| Revue de littérature |
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Neurological Damage by Coronaviruses: A Catastrophe in the Queue! |
Mishra, R, Banerjea, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Antiviral effect of visible light-sensitive cuxo/tio2 photocatalyst |
Miyauchi, M, Sunada, et al |
Catalysts |
Review Literature| Revue de littérature |
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Moiz, H, Tso, et al |
Clin Exp Dermatol |
Review Literature| Revue de littérature |
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Montero-Oleas, N, Puente-Vallejo, et al |
Medwave |
Review Literature| Revue de littérature |
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A review on role of rasayanain prevention and management (As an adjuvant) of COVID-19 |
Mude, R, Kuchewar, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Niraj, S, Varsha, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Epidemic and pandemic viral infections: impact on tuberculosis and the lung: A consensus
|
Ong, CWM, Migliori, et al |
Eur Respir J |
Review Literature| Revue de littérature |
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Owen, L, Laird, et al |
PeerJ |
Review Literature| Revue de littérature |
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Pamukçu, B |
Anatol J Cardiol |
Review Literature| Revue de littérature |
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PMC7521571; Keeping track of the SARS-CoV-2 vaccine pipeline |
Parker, EPK, Shrotri, et al |
Nat Rev Immunol |
Review Literature| Revue de littérature |
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Parlakpinar, H, Gunata, et al |
Cell Biochem Funct |
Review Literature| Revue de littérature |
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Patwardhan, RB, Abhyankar, et al |
Disaster Advances |
Review Literature| Revue de littérature |
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Petushkova, AI, Zamyatnin, et al |
Pharmaceuticals (Basel) |
Review Literature| Revue de littérature |
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Phillip, M, Bergenstal, et al |
Diabetes Technol Ther |
Review Literature| Revue de littérature |
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Poddighe, D, Aljofan, et al |
Antiviral Chemistry and Chemotherapy |
Review Literature| Revue de littérature |
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Genomic Epidemiology and Recent Update on Nucleic Acid–Based Diagnostics for COVID-19 |
Rabaan, AA, Al-Ahmed, et al |
Current Tropical Medicine Reports |
Review Literature| Revue de littérature |
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Coronavirus (Covid-19) and entrepreneurship: cultural, lifestyle and societal changes |
Ratten, V |
Journal of Entrepreneurship in Emerging Economies |
Review Literature| Revue de littérature |
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Inflammasome-mediated immunogenicity of clinical and experimental vaccine adjuvants |
Reinke, S, Thakur, et al |
Vaccines |
Review Literature| Revue de littérature |
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Revzin, MV, Raza, et al |
Radiographics |
Review Literature| Revue de littérature |
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Ribeiro, R, Wainstein, et al |
Annals of Surgical Oncology |
Review Literature| Revue de littérature |
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Rimensberger, PC, Kneyber, et al |
Pediatr Crit Care Med |
Review Literature| Revue de littérature |
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Characteristics and treatment
of the oncologic patient in the midst of the current COVID-19 pandemic |
Rodríguez, CS, Falcón, et al |
Revista Habanera de Ciencias Medicas |
Review Literature| Revue de littérature |
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Infection and death in healthcare workers due to COVID-19: a systematic review |
Sant’Ana, G, Imoto, et al |
ACTA Paulista de Enfermagem |
Review Literature| Revue de littérature |
SR: To identify evidences regarding infection by SARS-CoV-2 and deaths of healthcare workers and related-risk factors.
A total of 28 articles were selected. Most mentioned risk factors were: scarcity, inadequate use or non-usage of personal protective equipment, work overload, close contact with potentially infected patients and/or coworkers, risk for aerosol-generating procedures,
late diagnosis and inadequate air renovation. According to each country, the number of infected workers ranged from 1,716 to 17,306. Concerning deaths, there are data of up to 605 healthcare workers who died of COVID-19 all over the world. Evidences found
were editorials, cross-sectional, and cohort studies. Conclusion: Studies identified showed high number of infection and deaths among healthcare workers. Overload of health system was a significant factor |
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Sepúlveda-Loyola, W, Rodríguez-Sánchez, et al |
Journal of Nutrition, Health and Aging |
Review Literature| Revue de littérature |
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Consensus guidelines on opening up of aesthetic practices in india during the covid-19 era |
Sethi, N, Singh, et al |
Clinical, Cosmetic and Investigational Dermatology |
Review Literature| Revue de littérature |
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Can medical practitioners rely on prediction models for COVID-19? A systematic review |
Shamsoddin, E |
Evidence-Based Dentistry |
Review Literature| Revue de littérature |
SR: This systematic review sought to assess and scrutinise the validity and practicality of published and preprint
reports of prediction models for the diagnosis of coronavirus disease 2019 (COVID-19) in patients with suspected infection, for prognosis of patients with COVID-19, and for identifying individuals in the general population at increased risk of infection with
COVID-19 or being hospitalised with the illness. One hundred and forty-five prediction models (107 studies) were selected for data extraction and critical appraisal. The most common predictors of diagnosis and prognosis of COVID-19 were age, body temperature,
lymphocyte count and lung imaging characteristics. Influenza-like symptoms and neutrophil count were regularly predictive in diagnostic models, while comorbidities, sex, C-reactive protein and creatinine were common prognostic items. C-indices (a measure of
discrimination for models) ranged from 0.73 to 0.81 in prediction models for the general population, from 0.65 to more than 0.99 in diagnostic models, and from 0.68 to 0.99 in the prognostic models.
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Shao, S, Wang, et al |
Int J Infect Dis |
Review Literature| Revue de littérature |
SR: To determine whether convalescent blood products (CBPs) could offer a survival advantage for patients with severe
acute respiratory infections (SARI) of viral etiology. The all-cause mortality in the randomized controlled trials (RCTs) showed no difference between the interventional group and the control group (OR 0.82; 95% CI 0.57 to 1.19; P = 0.30). Besides, CBPs did
not increase the risk of adverse events between these two groups (OR 0.88; 95% CI 0.60-1.29; P = 0.51). Using CBPs earlier, compared with using CBPs later, was associated with a significant reduction in all-cause mortality (OR 0.18; 95% CI 0.08-0.40; P < 0.0001).
CONCLUSIONS: Based on the outcomes of RCTs, CBPs could not decrease all-cause mortality. Furthermore, comparing with later initiation of convalescent blood product therapy, earlier initiation of convalescent blood product therapy might decrease the rate of
mortality. |
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Shaw, B, Daskareh, et al |
Radiol Med |
Review Literature| Revue de littérature |
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COVID-19 and OCD: Potential impact of exposure and response prevention therapy |
Sheu, JC, McKay, et al |
Journal of anxiety disorders |
Review Literature| Revue de littérature |
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Sidorenko-Bautista, P, de la Casa, et al |
Tripodos |
Review Literature| Revue de littérature |
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Nutritional Risk Screening Tools for Older Adults with COVID-19: A Systematic Review |
Silva, DFO, Lima, et al |
Nutrients |
Review Literature| Revue de littérature |
SR: Coronavirus disease 2019 (COVID-19) is associated with high risk of malnutrition, primarily in older people; assessing
nutritional risk using appropriate screening tools is critical. This systematic review identified applicable tools and assessed their measurement properties. |
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Simoni, P, Bazzocchi, et al |
J Med Imaging Radiat Oncol |
Review Literature| Revue de littérature |
SR: To describe the chest CT features reported in children with confirmed COVID-19 infection, published in English
literature. Nine articles were included for the data extraction and in the final analysis. Chest CT features in children with COVID-19 differ from those in adults. 'Ground-grass opacities' (GGOs) are the most commonly described abnormalities, but closely
followed by a combination of GGO and consolidation, not usual in adults. Children tend to have a more variable involvement than the subpleural and posterior and basal topography described in adults. Interlobular thickening and air bronchogram found in adults
with COVID-19 are not frequent in children. Pulmonary embolism reported in up to 30% of adults has not been yet reported in children. Original articles describing chest CT features in children with COVID-19 in the English literature are limited to small populations
of Chinese children. Chest CT imaging features are very diverse across the selected studies and globally different from those reported in adults.
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Singh, D, Joshi, et al |
Epidemiol Infect |
Review Literature| Revue de littérature |
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Smith, DK, Casper, et al |
International Journal of Sport Communication |
Review Literature| Revue de littérature |
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COVID-19 and Parent Intention to Vaccinate Their Children Against Influenza |
Sokol, RL, Grummon, et al |
Pediatrics |
Review Literature| Revue de littérature |
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A Review on the Neurological Manifestations of COVID-19 Infection: a Mechanistic View |
Soltani Zangbar, H, Gorji, et al |
Molecular neurobiology |
Review Literature| Revue de littérature |
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Sopeyin, A, Hornsey, et al |
BMJ Global Health |
Review Literature| Revue de littérature |
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Sorbello, M, Rosenblatt, et al |
British journal of anaesthesia |
Review Literature| Revue de littérature |
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Spivakovsky, S |
Evidence-Based Dentistry |
Review Literature| Revue de littérature |
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COVID-19 and air pollution and meteorology-an intricate relationship: A review |
Srivastava, A |
Chemosphere |
Review Literature| Revue de littérature |
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Contemporary treatment modalities for the management of SARS-CoV-2 positive patients: An overview |
Srivastava, R, Rathi, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Early diagnosis and population prevention of coronavirus disease 2019 |
Su, YY, Zhang, et al |
Curr Opin HIV AIDS |
Review Literature| Revue de littérature |
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Szegedi, I, Orbán-Kálmándi, et al |
J Clin Med |
Review Literature| Revue de littérature |
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Telehealth and the Community SMI Population: Reflections on the Disrupter Experience of COVID-19 |
Talley, RM, Brunette, et al |
J Nerv Ment Dis |
Review Literature| Revue de littérature |
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Tamer, SI, Demiröz, et al |
Gazi Medical Journal |
Review Literature| Revue de littérature |
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Task force climate change: A patron saint of lost causes, or just ahead of its time? |
Titley, DW |
Daedalus |
Review Literature| Revue de littérature |
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A search in the surge of treatment for covid-19 patients: A narrative literature review |
Ugrappa, S, Jain, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Usta, DY, Teksin, et al |
Gazi Medical Journal |
Review Literature| Revue de littérature |
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Vasishta, PA, Anjali, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Velagaleti, RS, Vasan, et al |
J Am Heart Assoc |
Review Literature| Revue de littérature |
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Emergency medicine response to the COVID-19 pandemic in England: a phenomenological study |
Walton, H, Navaratnam, et al |
Emerg Med J |
Review Literature| Revue de littérature |
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HIV care during the coronavirus disease-2019 pandemic in Shenzhen, China |
Wang, H |
Curr Opin HIV AIDS |
Review Literature| Revue de littérature |
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Coronavirus disease-19 vaccine development utilizing promising technology |
Wang, Y, Xing, et al |
Curr Opin HIV AIDS |
Review Literature| Revue de littérature |
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Weston, D, Ip, et al |
BMC Public Health |
Review Literature| Revue de littérature |
Umbrella review: The current paper presents a synthesis of review literature discussing the application of behaviour
change theories within an infectious disease and emergency response context, with a view to informing infectious disease modelling, research and public health practice. METHODS: A scoping review procedure was adopted for the searches. Searches were run on
PubMed, PsychInfo and Medline with search terms covering four major categories: behaviour, emergency response (e.g., infectious disease, preparedness, mass emergency) |
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COVID-19 Threatens Progress Toward Gender Equity Within Academic Medicine |
Woitowich, NC, Jain, et al |
Acad Med |
Review Literature| Revue de littérature |
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Wolor, CW, Aminah, et al |
International Journal of Criminology and Sociology |
Review Literature| Revue de littérature |
SR (not COVID-19): The purpose of this study is to find out and explain the effectiveness of virtual working to achieve
optimal employee performance amid the covid-19 pandemic |
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Quality of early evidence on the pathogenesis, diagnosis, prognosis and treatment of COVID-19 |
Yang, S, Li, et al |
BMJ Evid Based Med |
Review Literature| Revue de littérature |
SR: We studied the trends and quality of evidence in early SARS-CoV-2 publications.
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32972277; Mesenchymal stem cell research progress for the treatment of COVID-19 |
Yao, D, Ye, et al |
Journal of International Medical Research |
Review Literature| Revue de littérature |
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Yimer, B, Ashebir, et al |
Disaster Med Public Health Prep |
Review Literature| Revue de littérature |
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Zhou, QA, Kato-Weinstein, et al |
ACS Pharmacology and Translational Science |
Review Literature| Revue de littérature |
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32947043; Chloroquine against malaria, cancers and viral diseases |
Zhou, W, Wang, et al |
Drug discovery today |
Review Literature| Revue de littérature |
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Zhou, X, Jiang, et al |
ACS Nano |
Review Literature| Revue de littérature |
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Zupo, R, Castellana, et al |
Int J Environ Res Public Health |
Review Literature| Revue de littérature |
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Future scenarios and opportunities for interventional radiology in the post COVID-19 era |
Abadal, JM, Gonzalez-Nieto, et al |
Diagn Interv Radiol |
Commentary/Editorial| Commentaire/Éditorial |
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Abdelmaksoud, A, Goldust, et al |
Int J Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Acker, KP, Schertz, et al |
Clin Pediatr (Phila) |
Commentary/Editorial| Commentaire/Éditorial |
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Adams, RD, Tyson, et al |
Social Work in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Adorjan, K, Gaudernack, et al |
Nervenarzt |
Commentary/Editorial| Commentaire/Éditorial |
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Comment on: COVID-19 outbreak and the practice of surgery: do we need to change? |
Agrawal, V, Seth, et al |
Br J Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Agrawal, V, Sharma, et al |
Br J Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Unmasking the hidden pandemic: sustainability in the setting of the COVID-19 pandemic |
Ahmadifard, A |
British dental journal |
Commentary/Editorial| Commentaire/Éditorial |
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Ahmed, SB, Dumanski, et al |
Can J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Ahmed, Z, Zeeshan, et al |
BMJ Innovations |
Commentary/Editorial| Commentaire/Éditorial |
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Pathophysiology of coronavirus disease 2019 for wound care professionals |
Al-Benna, S |
Int Wound J |
Commentary/Editorial| Commentaire/Éditorial |
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International Trade Norms in the Age of Covid-19 Nationalism on the Rise? |
Albertoni, N, Wise, et al |
Fudan Journal of the Humanities and Social Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Management of obesity in Saudi Arabia during the era of COVID-19: A clash of two pandemics |
Alfaris, N |
Obesity (Silver Spring) |
Commentary/Editorial| Commentaire/Éditorial |
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Alvarado, GR, Pierson, et al |
JAMA Netw Open |
Commentary/Editorial| Commentaire/Éditorial |
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The Proliferation of Solar Photovoltaics: Their Impact on Widespread Deployment of Electric Vehicles |
Aminifar, F, Shahidehpour, et al |
IEEE Electrification Magazine |
Commentary/Editorial| Commentaire/Éditorial |
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Aerosol Treatments During COVID-19 Pandemic: A Personal Journey |
Amirav, I |
J Aerosol Med Pulm Drug Deliv |
Commentary/Editorial| Commentaire/Éditorial |
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Surveys on COVID-19 in nuclear medicine: what happened and what we learned |
Annunziata, S, Albano, et al |
Clinical and Translational Imaging |
Commentary/Editorial| Commentaire/Éditorial |
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Anthes, E |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Anuragi, RP, Kansal, et al |
Dermatol Ther |
Commentary/Editorial| Commentaire/Éditorial |
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Appleby, J |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Arumalla, VK, Patil, et al |
Geriatr Gerontol Int |
Commentary/Editorial| Commentaire/Éditorial |
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Fólk sem fékk COVID-19
en lagdist ekki á spítala parf endurhæfingu |
Ásgeirsdóttir, M |
Laeknabladid |
Commentary/Editorial| Commentaire/Éditorial |
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Aubry, JM, Gasser, et al |
Revue medicale suisse |
Commentary/Editorial| Commentaire/Éditorial |
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Azizoddin, DR, Vella Gray, et al |
J Interprof Care |
Commentary/Editorial| Commentaire/Éditorial |
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Baghdadli, A, Picot, et al |
J Autism Dev Disord |
Commentary/Editorial| Commentaire/Éditorial |
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Reply to "SARS-CoV-2-associated critical ill myopathy or pure toxic myopathy?" |
Bagnato, S, Boccagni, et al |
Int J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Reproduction of communicative
negativity through instrumental irrationality |
Baloglu, U |
Tripodos |
Commentary/Editorial| Commentaire/Éditorial |
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Bashar, AHM, Hakim, et al |
Annals of Vascular Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Batelaan, K |
Social Identities |
Commentary/Editorial| Commentaire/Éditorial |
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Battinelli, EM |
Blood |
Commentary/Editorial| Commentaire/Éditorial |
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International education in New Zealand: contemplating a new dawn following COVID-19’s darkest
night |
Beard, C |
Higher Education Research and Development |
Commentary/Editorial| Commentaire/Éditorial |
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Bellgrau, D, Modiano, et al |
Scand J Immunol |
Commentary/Editorial| Commentaire/Éditorial |
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RRF102: Meeting the TREC-COVID Challenge with a 100+ Runs Ensemble |
Bendersky, Michael, Zhuang, et al |
ArXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Evaluation of alcohol content of cologne products in the Turkish market amid the covid-19 pandemic |
Berkkan, A, Ulutaş, et al |
Gazi Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Berkman, PA |
The Hague Journal of Diplomacy |
Commentary/Editorial| Commentaire/Éditorial |
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Bermano, G, Méplan, et al |
Br J Nutr |
Commentary/Editorial| Commentaire/Éditorial |
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Stroke care in Italy at the time of the COVID-19 pandemic: a lesson to learn |
Bersano, A, Pantoni, et al |
Journal of neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Bilbao, GM |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
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Bilgin, YM, Kusadasi, et al |
Netherlands Journal of Critical Care |
Commentary/Editorial| Commentaire/Éditorial |
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Bingaman, J |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Biswas, A, Chandankhede, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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32912354; Underreporting COVID-19: the curious case of the Indian subcontinent |
Biswas, RK, Afiaz, et al |
Epidemiology and infection |
Commentary/Editorial| Commentaire/Éditorial |
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Promoting access to COVID-19 convalescent plasma in low- and middle-income countries |
Bloch, EM, Goel, et al |
Transfusion and Apheresis Science |
Commentary/Editorial| Commentaire/Éditorial |
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Immunomodulatory measures to strengthen the body during covid outbreak |
Boharupi, G, Shelotkar, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Bolognesi, M, Magnani, et al |
FEBS letters |
Commentary/Editorial| Commentaire/Éditorial |
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Bond, EU, , et al |
Journal of Service Research |
Commentary/Editorial| Commentaire/Éditorial |
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Bongiovanni, M |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
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Relationship between ABO blood groups and COVID-19: study design matters |
Boudin, L, Dutasta, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Bougakov, D, Podell, et al |
Mol Neurobiol |
Commentary/Editorial| Commentaire/Éditorial |
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The carnage of substandard research during the COVID-19 pandemic: a call for quality |
Bramstedt, KA |
J Med Ethics |
Commentary/Editorial| Commentaire/Éditorial |
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Brealey, JK, Miller, et al |
Br J Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Personal view: security sector health systems and global health |
Bricknell, M, Horne, et al |
BMJ Mil Health |
Commentary/Editorial| Commentaire/Éditorial |
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Beyond COVID-19: Five commentaries on reimagining governance for future crises and resilience |
Brousselle, A, Brunet-Jailly, et al |
Canadian Public Administration |
Commentary/Editorial| Commentaire/Éditorial |
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Recognizing Privilege as a Social Determinant of Health during COVID-19 |
Brown, EA, White, et al |
Health Equity |
Commentary/Editorial| Commentaire/Éditorial |
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32712159; Telemedicine: dos and don'ts to mitigate liability risk |
Bruhn, HK |
Journal of AAPOS |
Commentary/Editorial| Commentaire/Éditorial |
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Misdiagnosis related to premature diagnostic closure during the COVID-19 pandemic |
Budhram, B, Kobza, et al |
Cmaj |
Commentary/Editorial| Commentaire/Éditorial |
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Bullard, JS, McAlister, et al |
NASN Sch Nurse |
Commentary/Editorial| Commentaire/Éditorial |
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Return to school in the COVID-19 era: considerations for temperature measurement |
Buoite Stella, A, Manganotti, et al |
J Med Eng Technol |
Commentary/Editorial| Commentaire/Éditorial |
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Buonsenso, D, Riitano, et al |
Frontiers in Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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Burki, Talha Khan |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19, Disparities, and Opportunities for Equity in Otolaryngology-Unequal America |
Burks, CA, Ortega, et al |
JAMA Otolaryngology - Head and Neck Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Managing COVID-19 from the epicenter: adaptations and suggestions based on experience |
Burnett, GW, Katz, et al |
J Anesth |
Commentary/Editorial| Commentaire/Éditorial |
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Emergency Mail-in Voting in Rhode Island: Protecting Civic Participation During COVID-19
and Beyond |
Burns, NM, Zahiri, et al |
R I Med J (2013) |
Commentary/Editorial| Commentaire/Éditorial |
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Butryn, TM, Masucci, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Cacciavillani, M, Salvalaggio, et al |
Muscle Nerve |
Commentary/Editorial| Commentaire/Éditorial |
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Calina, D, Sarkar, et al |
Immunol Res |
Commentary/Editorial| Commentaire/Éditorial |
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Making sense of coach development worldwide during the COVID-19 pandemic |
Callary, B, Brady, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Carey, N, Alkhamees, et al |
BMJ Open |
Commentary/Editorial| Commentaire/Éditorial |
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Physiopathology of SARS-CoV-2-infection-associated thrombosis |
Casella, IB |
Jornal Vascular Brasileiro |
Commentary/Editorial| Commentaire/Éditorial |
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Castro da Rocha, FA, Melo, et al |
Ann Rheum Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Implications of COVID-19
pandemic for dental care: A perspective for clinical dentists |
Castro-Rodríguez, Y, Valenzuela-Torres, et al |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
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Charlier, P, Donell, et al |
Ethics Med Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19, Cities and Urban Informal Workers: India in Comparative Perspective |
Chen, M |
Indian Journal of Labour Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Chen, Z |
Curr Opin HIV AIDS |
Commentary/Editorial| Commentaire/Éditorial |
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Palliative care for cancer patients with severe COVID-19: the challenge of uncertainty |
Cheng, HWB |
Support Care Cancer |
Commentary/Editorial| Commentaire/Éditorial |
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Digital Health Solutions for Mental Health Disorders During COVID-19 |
Chew, AMK, Ong, et al |
Frontiers in Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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The covid-19 Crisis: A Challenge for Numeric Comparative Law and Governance |
Ciacchi, AC |
European Journal of Comparative Law and Governance |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 effects on neuro-oncology publishing: preliminary outcomes & future impacts |
Cifarelli, CP, Sheehan, et al |
Journal of neuro-oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Clark, AE, Lee, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Clavenna, A, Nardelli, et al |
Pediatr Emerg Care |
Commentary/Editorial| Commentaire/Éditorial |
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Critiquing anthropocentric media coverage of the COVID-19 sport "hiatus" |
Clevenger, SM, Rick, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Behind the scenes: COVID-19 consequences on broadcast sports production |
Coche, R, Lynn, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Colmenero, I, Santonja, et al |
Br J Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Coons, S |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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Cormacain, R, Bar-Siman-Tov, et al |
Theory and Practice of Legislation |
Commentary/Editorial| Commentaire/Éditorial |
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Coronado-Arroyo, J, Concepción-Zavaleta, et al |
European Journal of Obstetrics and Gynecology and Reproductive Biology |
Commentary/Editorial| Commentaire/Éditorial |
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Cowley, S, White, et al |
Med Teach |
Commentary/Editorial| Commentaire/Éditorial |
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Cross, FL, Gonzalez Benson, et al |
Affilia - Journal of Women and Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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How to Mitigate the Mental Health Care Consequences of the COVID-19 Financial Crisis |
Cuellar, A, Mark, et al |
Psychiatr Serv |
Commentary/Editorial| Commentaire/Éditorial |
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Talking baseball when there is no baseball: Reporters and fans during the COVID-19 pandemic |
Curry, AL, Good, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Response to: What's the psychiatrist's role in the COVID-19 outbreak? |
Curtis, LM, Jenkins, et al |
Aust N Z J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Darbyshire, P, Dwyer, et al |
J Clin Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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Dash, S, Das, et al |
Indian Journal of Plastic Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Through the perilous fight: A case analysis of professional wrestling during the COVID-19 pandemic |
Davidson, NP, Du, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Davies, J, Randeva, et al |
Mol Med Rep |
Commentary/Editorial| Commentaire/Éditorial |
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de Bilbao, GM |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
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de Bilbao, GM |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
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de Bilbao, GM |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
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Alternative mechanical
ventilation systems in the SARS-CoV-2 pandemic: Ventijet |
de Bilbao, GM, Parrilla Gómez, et al |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
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de Blasio, E, Coll-Rubio, et al |
Tripodos |
Commentary/Editorial| Commentaire/Éditorial |
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Digital subscription systems
in the face of COVID-19 crisis: The case of 'El Mundo' |
de la Fuente, EC |
Tripodos |
Commentary/Editorial| Commentaire/Éditorial |
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Contract law and COVID
19 in Chile. Exceptional regulations and general law |
de la Maza Gazmuri, Í, Olivares, et al |
Revista de Derecho Civil |
Commentary/Editorial| Commentaire/Éditorial |
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de Lissovoy, G |
Med Care |
Commentary/Editorial| Commentaire/Éditorial |
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Consequences of gestational age limits for people needing abortion care during the COVID-19
pandemic |
De Zordo, S, Mishtal, et al |
Sex Reprod Health Matters |
Commentary/Editorial| Commentaire/Éditorial |
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Deeksha, K, Sachan, et al |
Disaster Advances |
Commentary/Editorial| Commentaire/Éditorial |
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Emergency Nursing Care of Patients With Novel Coronavirus Disease 2019 |
Deitrick, K, Adams, et al |
Journal of Emergency Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Antiretrovirals and Risk of COVID-19 Diagnosis and Hospitalization in HIV-Positive Persons |
Del Amo, J, Polo, et al |
Epidemiology |
Commentary/Editorial| Commentaire/Éditorial |
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Delanghe, JR, De Buyzere, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Sequelae of COVID-19 in Hospitalized Children: A 4-Months Follow-Up |
Denina, M, Pruccoli, et al |
Pediatr Infect Dis J |
Commentary/Editorial| Commentaire/Éditorial |
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Dening, Karen Harrison, Lloyd-Williams, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7388753; Ethical principles in decision-making during the COVID-19 pandemic |
Deps, P, Cassimiro, et al |
Ethics Med Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Deutsche Ophthalmologische, Gesellschaft, Berufsverband der Augenarzte Deutschlands e, et al |
Klinische Monatsblatter fur Augenheilkunde |
Commentary/Editorial| Commentaire/Éditorial |
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Neuroinvasion of SARS-CoV-2 may play a role in the breakdown of the respiratory center of the brain |
Dey, J, Alam, et al |
Journal of medical virology |
Commentary/Editorial| Commentaire/Éditorial |
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Venous Thromboembolism and Its Association with COVID-19: Still an Open Debate |
Di Micco, P, Russo, et al |
Medicina (Kaunas) |
Commentary/Editorial| Commentaire/Éditorial |
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Diener, HC |
MMW-Fortschritte der Medizin |
Commentary/Editorial| Commentaire/Éditorial |
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Wussten Sie schon ...?:
SARS-CoV-2 kann das Nervensystem angreifen |
Diener, HC |
Medizinische Monatsschrift fur Pharmazeuten |
Commentary/Editorial| Commentaire/Éditorial |
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Dirlikov, E, Fechter-Leggett, et al |
MMWR Morb Mortal Wkly Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Deficient Response to COVID-19 Makes the Case for Evolving the Public Health System |
Dixon, BE, Caine, et al |
American Journal of Preventive Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Drawing on the Past to Shape the Future of Synthetic Yeast Research |
Dixon, TA, Pretorius, et al |
Int J Mol Sci |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime |
Domingues, R, Lippi, et al |
Aging (Albany NY) |
Commentary/Editorial| Commentaire/Éditorial |
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Concrete Recommendations for Cutting Through Misinformation During the COVID-19 Pandemic |
Donovan, J |
Am J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Surveillance in Youth Soccer During Small Group Training: A Safe Return to Sports Activity |
Drezner, JA, Drezner, et al |
Sports Health |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Government poised to amend regulations to allow use of unlicensed vaccine |
Dyer, C |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Incidence and Outcomes of Thrombotic Events in Symptomatic Patients With COVID-19 |
Elbadawi, A, Elgendy, et al |
Arterioscler Thromb Vasc Biol |
Commentary/Editorial| Commentaire/Éditorial |
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In defence of extrapolation but not improvisation in sars-cov-2 lung disease |
Epelbaum, O, Galperin, et al |
Breathe |
Commentary/Editorial| Commentaire/Éditorial |
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Transformative dimensions of lifelong learning: Mezirow, Rorty and COVID-19 |
Eschenbacher, S, Fleming, et al |
International Review of Education |
Commentary/Editorial| Commentaire/Éditorial |
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Eslambolchi, A, Aghaghazvini, et al |
Journal of thrombosis and thrombolysis |
Commentary/Editorial| Commentaire/Éditorial |
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Esparza, J |
Gaceta medica de Caracas |
Commentary/Editorial| Commentaire/Éditorial |
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Restoring trust: COVID-19 and the future of long-term care in Canada |
Estabrooks, CA, Straus, et al |
Facets |
Commentary/Editorial| Commentaire/Éditorial |
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Etteh, CC, Adoga, et al |
Ethics Med Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Eurosurveillance editorial, team |
Eurosurveillance |
Commentary/Editorial| Commentaire/Éditorial |
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Evans, G |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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Evans, G |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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CDC's COVID-19 guidelines
on going out and gathering have cautions and caveats |
Evans, G |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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Evans, G |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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CDC updates guidance on
COVID-19 transmission in dental settings |
Evans, G |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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Fan, LL, Sheth, et al |
Contemporary OB/GYN |
Commentary/Editorial| Commentaire/Éditorial |
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Clinicians embracing social media in the response against COVID-19 |
Farid, Y, Di Siate, et al |
BMJ Innovations |
Commentary/Editorial| Commentaire/Éditorial |
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32959802; Bacterial coinfections in COVID-19: An underestimated adversary |
Fattorini, L, Creti, et al |
Annali dell'Istituto Superiore di Sanita |
Commentary/Editorial| Commentaire/Éditorial |
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From ESPN to instagram LIVE: The evolution of fan-athlete interaction amid the coronavirus |
Feder, L |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Fernández, A |
ACS Pharmacology and Translational Science |
Commentary/Editorial| Commentaire/Éditorial |
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Fernández-Pedemonte, D, Casillo, et al |
Tripodos |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2-associated critical ill myopathy or pure toxic myopathy? |
Finsterer, J, Scorza, et al |
Int J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Fischer-Fels, J |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7237375; COVID-19 Is Disproportionately High in African Americans. This Will Come as No
Surprise… |
Fouad, MN, Ruffin, et al |
Am J Med |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7241371; Pulmonary embolism and COVID-19: A paradigm change |
Franco-Moreno, A, Muñoz-Rivas, et al |
Rev Clin Esp |
Commentary/Editorial| Commentaire/Éditorial |
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Freaney, PM, Shah, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
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OSHA enforcement prioritizing
hazards related to COVID-19 response |
Freeman, G, Dorr, et al |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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Frimpong, S, Paintsil, et al |
Yale J Biol Med |
Commentary/Editorial| Commentaire/Éditorial |
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Will philanthropy save us all? Rethinking urban philanthropy in a time of crisis |
Fuentenebro, P |
Geoforum |
Commentary/Editorial| Commentaire/Éditorial |
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The Importance of Dental Military Officers During the COVID-19 Pandemic |
Galletti, CA, J, et al |
J Craniofac Surg |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7266749; COVID-19 disease: the hospital of the future is already here |
García-Alegría, J, Gómez-Huelgas, et al |
Rev Clin Esp |
Commentary/Editorial| Commentaire/Éditorial |
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García-Fernández, A, Ramos-Ruiz, et al |
Revista espanola de cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
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Geng-Ramos, G, Cronin, et al |
Paediatric anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Can a ‘second disaster’ during and after the COVID-19 pandemic be mitigated? |
Gersons, BPR, Smid, et al |
European Journal of Psychotraumatology |
Commentary/Editorial| Commentaire/Éditorial |
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Foreword for special issue on legislatures in the time of Covid-19 |
Ginsburg, T |
Theory and Practice of Legislation |
Commentary/Editorial| Commentaire/Éditorial |
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Girdharwal, N, Kumar, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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From liberalism to biopolitics: investigating the Norwegian government’s two responses to
Covid-19 |
Gjerde, LEL |
European Societies |
Commentary/Editorial| Commentaire/Éditorial |
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Antithrombotic therapy in patients with COVID-19? -Rationale and Evidence |
Godino, C, Scotti, et al |
Int J Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
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Rebooting content: Broadcasting sport and esports to homes during COVID-19 |
Goldman, MM, Hedlund, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19-Related Anosmia: The Olfactory Pathway Hypothesis and Early Intervention |
Gori, A, Leone, et al |
Frontiers in Neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Gray, DP, Freeman, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Returning to school: children and young people living with chronic illness |
Gray, NJ, Jourdan, et al |
Journal of Children's Services |
Commentary/Editorial| Commentaire/Éditorial |
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Greenhouse, S |
Dissent |
Commentary/Editorial| Commentaire/Éditorial |
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Guidelines for the Perplexed: How to Maximize Colonoscopy Efficiency During the COVID-19 Pandemic |
Grossi, E, Pace, et al |
Dig Dis Sci |
Commentary/Editorial| Commentaire/Éditorial |
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Gulhane, A, Hiware, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Nýta gagnabanka sidekick
til að meta þróun veikinda covid-19-sjúkra |
Gunnarsdóttir, GA |
Laeknabladid |
Commentary/Editorial| Commentaire/Éditorial |
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Györfi, AH, Schett, et al |
Ann Rheum Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Hamdanieh, L, Ostadtaghizadeh, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
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The elephant in the room: How COVID-19's financial impact further threatens title IX compliance |
Hartman, KL |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
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A numerical solution by alternative Legendre polynomials on a model for novel coronavirus (COVID-19) |
Hashemizadeh, E, Ebadi, et al |
Advances in Difference Equations |
Commentary/Editorial| Commentaire/Éditorial |
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Hassanein, M, Radhakrishnan, et al |
Cleve Clin J Med |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 Pandemic as an Imperative to Advance Medical Student Assessment: Three Areas for
Change |
Hauer, KE, Lockspeiser, et al |
Acad Med |
Commentary/Editorial| Commentaire/Éditorial |
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Helfand, BKI, Webb, et al |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Hofer, U, Du Toit, et al |
Nat Rev Microbiol |
Commentary/Editorial| Commentaire/Éditorial |
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Holder, K, Reddy, et al |
Neuroscientist |
Commentary/Editorial| Commentaire/Éditorial |
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Holmgren, AJ, Apathy, et al |
J Am Med Inform Assoc |
Commentary/Editorial| Commentaire/Éditorial |
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Horton, Richard |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7521372; The potential indicators for pulmonary fibrosis in survivors of severe COVID-19 |
Huang, W, Wu, et al |
J Infect |
Commentary/Editorial| Commentaire/Éditorial |
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32959968; The COVID-19 Crisis and its impact on congenital cardiac surgery charitable endeavors |
Hubbard, R, Latham, et al |
Paediatric anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Comparing Sweden's response with the UK's is "misleading," experts argue |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Glitch leaves users unable to link test results to new contact tracing app |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Politicians must be honest about what NHS can deliver during pandemic, say leaders |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: NHS staff must be tested weekly to keep services running, say MPs |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: GPs need extra support to withstand second wave, BMA warns |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Easing of lockdown measures in Nigeria: Implications for the healthcare system |
Ibrahim, RL, Ajide, et al |
Health Policy and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Imoto, W, Kaga, et al |
Qjm |
Commentary/Editorial| Commentaire/Éditorial |
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Preprocedural Use of Povidone-Iodine Mouthwash during Dental Procedures in the COVID-19 Pandemic |
Imran, E, Khurshid, et al |
Eur J Dent |
Commentary/Editorial| Commentaire/Éditorial |
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Biological Factors Linking ApoE ε4 Variant and Severe COVID-19 |
Inal, J |
Curr Atheroscler Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Ino, H |
Geriatr Gerontol Int |
Commentary/Editorial| Commentaire/Éditorial |
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Provision of COVID-19 Convalescent Plasma in a Resource-Constrained State |
Ipe, TS, Le, et al |
Transfusion |
Commentary/Editorial| Commentaire/Éditorial |
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Jaafar, R, Aherfi, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Jacobson, TA, Smith, et al |
Int J Equity Health |
Commentary/Editorial| Commentaire/Éditorial |
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Jafari, A, Rezaei-Tavirani, et al |
Risk Management and Healthcare Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Jahangiri, M, Cousins, et al |
Work (Reading, Mass.) |
Commentary/Editorial| Commentaire/Éditorial |
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Jaisankar, AI, Nandhakumar, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Jaiswal, A, Borage, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Mitral Annular Plane Systolic Excursion: An Early Marker of Mortality in Severe COVID-19 |
Jarori, U, Maatman, et al |
Journal of the American Society of Echocardiography |
Commentary/Editorial| Commentaire/Éditorial |
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Javanmard-Emamghissi, H, Boyd-Carson, et al |
Techniques in Coloproctology |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7386423; Choosing which COVID-19 patient to save? The ethical triage and rationing dilemma |
Jaziri, R, Alnahdi, et al |
Ethics Med Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Correspondence on 'Glucocorticoid-induced relapse of COVID-19 in a patient with sarcoidosis' |
Jeny, F, Lhote, et al |
Ann Rheum Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Jeong, A, Sagong, et al |
Infection and Chemotherapy |
Commentary/Editorial| Commentaire/Éditorial |
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Jevon, P, Abdelrahman, et al |
British dental journal |
Commentary/Editorial| Commentaire/Éditorial |
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Considerations on the clinical development of COVID-19 vaccine from trial design perspectives |
Jiang, Z, Wang, et al |
Hum Vaccin Immunother |
Commentary/Editorial| Commentaire/Éditorial |
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The imaginary of an invisible
enemy: The SARS-CoV-2 virion on the Spanish TV news |
Jiménez-Gómez, I, López-Díez, et al |
Tripodos |
Commentary/Editorial| Commentaire/Éditorial |
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Governmental communication
and brand advertising during the COVID-19 pandemic |
Jiménez-Sánchez, Á, Margalina, et al |
Tripodos |
Commentary/Editorial| Commentaire/Éditorial |
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Adverse events associated with potential drugs for COVID-19: a case study from real-world data |
Jing, Y, Diao, et al |
Brief Bioinform |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Statement: The unanticipated costs of COVID-19 to South Africa's quadruple disease burden |
John Ataguba, Prof, Ayo-Yusuf, et al |
South African Journal of Science |
Commentary/Editorial| Commentaire/Éditorial |
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Johnson, MDL |
mSphere |
Commentary/Editorial| Commentaire/Éditorial |
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Joob, B, Wiwanikit, et al |
Infection and Chemotherapy |
Commentary/Editorial| Commentaire/Éditorial |
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Evidence of Protective Effect of Hydroxychloroquine on COVID-19 |
Joob, B, Wiwanitkit, et al |
J Rheumatol |
Commentary/Editorial| Commentaire/Éditorial |
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How Africa Is Promoting Agricultural Innovations and Technologies amidst the COVID-19 Pandemic |
Joseph Fernando, A |
Molecular Plant |
Commentary/Editorial| Commentaire/Éditorial |
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Joseph, MB, Pohekar, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Joseph, SJ, Bhandari, et al |
International Journal of Social Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Regulators are mounting
a concerted effort against covid-19 – will it be enough? |
Kakkaiyadi, K, Subramaniam, et al |
Regulatory Rapporteur |
Commentary/Editorial| Commentaire/Éditorial |
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Kalkman, JP |
Journal of Contingencies and Crisis Management |
Commentary/Editorial| Commentaire/Éditorial |
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Kamde, S, Sawarkar, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Kameswari, S, Lakshmi, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Kapp, CM, Zaeh, et al |
Anesthesia and Analgesia |
Commentary/Editorial| Commentaire/Éditorial |
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Karahalil, B, Deniz, et al |
Gazi Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Katz, C, Fallon, et al |
Child Abuse and Neglect |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Has Provided 20/20 Vision Illuminating Our Nation's Health Crises |
Katzman, JG, Katzman, et al |
Pain Med |
Commentary/Editorial| Commentaire/Éditorial |
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Effect of awake prone positioning in hypoxaemic adult patients with COVID-19 |
Kelly, NL, Curtis, et al |
Journal of the Intensive Care Society |
Commentary/Editorial| Commentaire/Éditorial |
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Khan, ZA, Yumnamcha, et al |
Frontiers in Endocrinology |
Commentary/Editorial| Commentaire/Éditorial |
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New safety measure for the endoscopic procedures during the COVID-19 pandemic: New STEP |
Kikuchi, D, Suzuki, et al |
VideoGIE |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kim, AW |
American Journal of Human Biology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kim, Y, Sung, et al |
J Korean Med Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
King, KR |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Do we really want sports public relations to return to normal? |
Kleinmann, CM |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Klimczak, A |
World Journal of Stem Cells |
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|
|
|
Kobayashi, R, Hayashi, et al |
Psychogeriatrics |
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|
|
Koley, TK, Dhole, et al |
The COVID-19 Pandemic: The Deadly Coronavirus Outbreak |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kollias, A, Kyriakoulis, et al |
Progress in cardiovascular diseases |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid-19: public messaging on vaccination must heed warnings from confused face mask messaging |
Kolstoe, SE |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Konwarh, R |
Frontiers in Molecular Biosciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Glove-Wall System for Respiratory Specimen Collection and COVID-19 Mass Screening |
Koo, BK, Bang, et al |
Infection and Chemotherapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kopec, K, Janney, et al |
Prim Care Companion CNS Disord |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Remote CBT for Psychosis During the COVID-19 Pandemic: Challenges and Opportunities |
Kopelovich, SL, Turkington, et al |
Community Ment Health J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Emerging Life Sciences and Possible Threats to International Security |
Kosal, ME |
Orbis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kosmaczewska, A, Frydecka, et al |
Pol Arch Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Kostoff, RN, Briggs, et al |
Int J Mol Med |
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|
|
|
Kou, W, Li, et al |
Chinese Journal of Orthopaedic Trauma |
Commentary/Editorial| Commentaire/Éditorial |
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"Covidsubo": Stress-Induced Cardiomyopathy by Novel Coronavirus Disease 2019 |
Koutroumpakis, E, Taylor, et al |
Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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|
Kow, CS, Hasan, et al |
Obesity |
Commentary/Editorial| Commentaire/Éditorial |
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|
Kraenzlin, S, Meyer, et al |
Swiss Journal of Economics and Statistics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Krasińska, A, Wichrowska, et al |
Acta Angiologica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Digital tools for the
fight against COVID-19: Can a second wave be avoided? |
Kretzschmar, MEE, Bruijning-Verhagen, et al |
Nederlands tijdschrift voor geneeskunde |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The norwegian football family and strategic crisis communication |
Kristiansen, E, Dille, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Appointment of judges
to the higher judiciary during the pandemic - I |
Kumar, AP |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32959967; Simple technique for Capnography monitoring in COVID-19 paediatrics patient |
Kumar, N, Kumar, et al |
Paediatric anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
|
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An approach to the understanding of the clinical-etiopathological aspect of COVID-19 (SARS-CoV-2) |
Kumari, M, Agrawal, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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32623451; ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank |
Kuo, CL, Pilling, et al |
The journals of gerontology.Series A, Biological sciences and medical sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kupferschmidt, K |
Science |
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|
|
|
Kuznetsova, L |
Frontiers in Public Health |
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|
|
|
Laferrara, V, Justel-Vázquez, et al |
Tripodos |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lang, AE, Yakhkind, et al |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Coronavirus disease 2019 and sudden sensorineural hearing loss |
Lang, B, Hintze, et al |
J Laryngol Otol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lechien, JR, Circiu, et al |
Eur Arch Otorhinolaryngol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Letter to the Editor: The Interpretation of COVID-19 Seroprevalence Study Should Be Cautious |
Lee, J, Kim, et al |
J Korean Med Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
New Paradigm of Pediatric Clinical Clerkship during the Epidemic of COVID-19 |
Lee, YM, Park, et al |
J Korean Med Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Measures in England relating
to the COVID-19 crisis with an impact on private law |
Lein, E |
Revista de Derecho Civil |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Swiss legislative measures
relating to the COVID-19 crisis with an impact on private law |
Lein, E |
Revista de Derecho Civil |
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|
|
Leite, FPM, Curi, et al |
J Surg Oncol |
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|
|
|
32911555; Beyond the First Wave: Consequences of COVID-19 on High-Risk Infants and Families |
Lemmon, ME, Chapman, et al |
American Journal of Perinatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Leonard, WR |
American Journal of Human Biology |
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|
|
|
Letaief, F, Gharbi, et al |
J Oncol Pharm Pract |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7236709; Racial Inequalities in Mortality from Coronavirus: The Tip of the Iceberg |
Levine, RS, Johnson, et al |
Am J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Lew, SQ, Wallace, et al |
Am J Kidney Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Fake news travels fast: Exploring misinformation circulated around Wu Lei's coronavirus case |
Li, B, Scott, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Global COVID-19 pandemic demands joint interventions for the suppression of future waves |
Li, R, Chen, et al |
Proc Natl Acad Sci U S A |
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|
|
Lidington, EK, Smrke, et al |
Cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The COVID-19 Pandemic Battlefield: Protection of Long Term Care Hospitals |
Lim, S |
Infection and Chemotherapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 in long-term care homes in Ontario and British Columbia |
Liu, M, Maxwell, et al |
Cmaj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kidney disease and coronavirus
(COVID-19): prevention and control of infection in hemodialysis |
López, AB, Fonseca Gutiérrez, et al |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 and soccer teams on instagram: The case of corporate social responsibility |
López-Carril, S, Anagnostopoulos, et al |
International Journal of Sport Communication |
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|
|
COVID-19 and priorities in the department of neurosurgery: the limitations of the neurosurgeon |
Lozada, I, Bolaño, et al |
J Neurosurg Sci |
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|
|
The Transformational Effects of COVID-19 on Medical Education |
Lucey, CR, Johnston, et al |
JAMA - Journal of the American Medical Association |
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|
|
Luo, CH, Ma, et al |
Frontiers in Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Luque, A, Maniglio, et al |
Tripodos |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lynch, DA, Medalia, et al |
Frontiers in Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Lytras, T, Tsiodras, et al |
Scandinavian Journal of Public Health |
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|
|
|
Ma, SH, Tai, et al |
Dermatologica Sinica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Anti-inflammatory aspects of Lidocaine: a neglected therapeutic stance for COVID-19 |
Maab, H, Mustafa, et al |
Heart and Lung |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Implementing E-mentoring with care-experienced youth under “lock-down” – a South African experience |
MacDonald, M, Dellis, et al |
Journal of Children's Services |
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|
|
Madan, M, Kunal, et al |
Clinical rheumatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Improving the Safety of High-Flow Therapies in the Management of Patients With COVID-19 |
Madney, YM, Esquinas, et al |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mahapatra, J, Nikhade, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32912858; Operation Moonshot: GP clinics could be used to improve access to covid-19 tests |
Mahase, E |
BMJ (Clinical research ed.) |
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|
|
Covid-19: Vaccine roll out could take a year and will require difficult prioritisation decisions |
Mahase, E |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19: Anti-TNF drug adalimumab to be trialled for patients in the community |
Mahase, E |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Major, J, Wack, et al |
J Exp Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Providing Evidence-Based Practice During the COVID-19 Pandemic |
Makic, MBF |
Crit Care Nurse |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mal, DK, Mukherjee, et al |
Asia Pac J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
USS Theodore Roosevelt, COVID-19, and Ships: Lessons Learned |
Malone, JD |
JAMA Netw Open |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mandal, AKJ, Baktash, et al |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A framework for performance analysis on machine learning algorithms using covid-19 dataset |
Maram, B, Padmapriya, et al |
Advances in Mathematics: Scientific Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Martinez, CC, Maples, et al |
Applied Economic Perspectives and Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Thoughts From the Trenches: Should We Look at the “Healthy”? |
Martínez-Taboada, VM, López-Hoyos, et al |
Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mattei, G, Russo, et al |
International Journal of Social Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
What a Joe Biden presidency would mean for five key science issues |
Maxmen, A, Subbaraman, et al |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Inner Workings: Researchers race to develop in-home testing for COVID-19, a potential game changer |
McDermott, A |
Proc Natl Acad Sci U S A |
Commentary/Editorial| Commentaire/Éditorial |
|
|
McMahon, JamesH, Hoy, et al |
The Lancet |
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|
|
|
Médica de Bilbao, G, Altuna, et al |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mehta, J, Baliga, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Melchor, L |
The Hague Journal of Diplomacy |
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|
|
|
32925136; Rising incidence of musculoskeletal discomfort in the wake of the COVID-19 crisis |
Memari, A, Shariat, et al |
Work (Reading, Mass.) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Meneses, E, McKenney, et al |
Am J Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Meng, X, Liu, et al |
Science China Life Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Meyer, H |
Health Aff (Millwood) |
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|
|
|
Mian, P, Van Der Zanden, et al |
Pharmaceutisch weekblad |
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|
|
|
Miao, J, Zeng, et al |
Chinese Sociological Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mikša, MJ |
Farmaceutski Glasnik |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
What We Need to Know and How We Need to Act during the Coronavirus Pandemic as Vascular Surgeons |
Min, SK |
Vasc Specialist Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Teleophthalmology for age-related macular degeneration during the COVID-19 pandemic and beyond |
Mintz, J, Labiste, et al |
J Telemed Telecare |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mirabito, T, Hardin, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mitchell, MA |
Daedalus |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mitrasinovic, PM |
Acta Chimica Slovenica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Miyazawa, DD |
J Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Covid 19-A major cause of digital transformation in education or just an evaluation test |
Mladenova, T, Kalmukov, et al |
TEM Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Modes, ME, Lee, et al |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
PMC7521429; Sex differences in mortality in the intensive care unit patients with severe COVID-19 |
Moiseev, S, Brovko, et al |
J Infect |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mondada, L, Bänninger, et al |
Journal of Sociolinguistics |
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|
|
|
COVID-19-associated diffuse leukoencephalopathy and cerebral microbleeds during puerperium |
Montes-Ramirez, J, Aquino-Lopez, et al |
Int J Gynaecol Obstet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Trauma and orthopaedics training amid COVID-19: A medical student's perspective |
Morgan, C, Dattani, et al |
Acta Orthop |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Mortimer, PP |
Rev Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mount, CE, Elson, et al |
Archives of Disease in Childhood |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Tracking Potential COVID-19 Outbreaks With Influenzalike Symptoms Urgent Care Visits |
Muchmore, B, Muchmore, et al |
Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Muermann, A, Rothschild, et al |
GENEVA Risk and Insurance Review |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mungroo, MR, Khan, et al |
Hosp Pract (1995) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Murray, P |
Qualitative Inquiry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nadkarni, GN |
Science Translational Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nah, SA, Singaravel, et al |
Acad Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Simulation-Based Up-Training in Response to the COVID-19 Pandemic |
Nair, SS, Kaufman, et al |
Simul Healthc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Narayan, P, Angelini, et al |
J Card Surg |
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|
|
|
Neha, N, Anjali, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Differences in SARS-CoV-2 recommendations from major ophthalmology societies worldwide |
Nguyen, AX, Gervasio, et al |
BMJ Open Ophthalmology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Kicking it through the uprights: getting it published after presenting at PAS |
Nigrovic, SE, Fine, et al |
Pediatr Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ten simple rules for supporting a temporary online pivot in higher education |
Nordmann, E, Horlin, et al |
PLoS Comput Biol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Risk Communication is Important for Environmental Engineering during COVID-19 |
Oerther, DB, Watson, et al |
Journal of Environmental Engineering (United States) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 outbreak: a potential threat to routine vaccination programme activities in Nigeria |
Ogundele, OA, Omotoso, et al |
Hum Vaccin Immunother |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Oposa, A, J |
Daedalus |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Golden pigment curcumin: An inspiring antiviral molecular model for COVID-19 drug design |
Orhan, IE, Sezer Senol Deniz, et al |
Gazi Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Owen, B, Shepherd, et al |
Evidence-Based Dentistry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Can SARS-CoV-2 Accumulate Mutations in the S-Protein to Increase Pathogenicity? |
Padhi, AK, Tripathi, et al |
ACS Pharmacology and Translational Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Could reperfusion pulmonary oedema explain worsening progress in COVID-19 pneumonia? |
Paksu, MS, Kilic, et al |
Emerg Med J |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19 |
Pantelis, C, Jayaram, et al |
Aust N Z J Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Parackova, Z, Zentsova, et al |
Cells |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32966253; Post-COVID-19
management guidelines for orthodontic practices |
Park, JH, Kim, et al |
Journal of clinical orthodontics : JCO |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Parrilla, F |
Circular Farmaceutica |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Renin Angiotensin System, COVID-19 and Male Fertility: Any Risk for Conceiving? |
Pascolo, L, Zito, et al |
Microorganisms |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Patra, A, Ravi, et al |
Anatomical Science International |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pawar, A, Pal, et al |
Phytother Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Challenges and opportunities in mental health services during the COVID-19 pandemic |
Peng, D, Wang, et al |
General Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Perman, SM |
Circulation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Perreault, J, Tremblay, et al |
Blood |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Petit, G, Tedds, et al |
Canadian Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pham, HH, Ho, et al |
Higher Education Research and Development |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32805309; COVID-19 outbreak in healthcare workers in hospitals in Trieste, North-east Italy |
Piapan, L, De Michieli, et al |
Journal of Hospital Infection |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Pickler, RH, Abshire, et al |
Nursing outlook |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pieterse, P, Dickson, et al |
Int J Health Plann Manage |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Piya, R, Shrestha, et al |
Journal of Nepal Health Research Council |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Pollard, CA, Morran, et al |
Physiol Genomics |
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|
|
|
Provenzi, L, Grumi, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Ways of Knowing the Pandemic With the Help of Prompted Autoethnography |
Pruulmann-Vengerfeldt, P |
Qualitative Inquiry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32969400; Potential Impact of the COVID-19 Pandemic on Sexual and Reproductive Health in Nepal |
Puri, MC, Stone, et al |
Journal of Nepal Health Research Council |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 and the gender employment gap among parents of young Children |
Qian, Y, Fuller, et al |
Canadian Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Co-circulation of COVID-19 and dengue: A perspective from Pakistan |
Rana, MS, Alam, et al |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rappaport, SM |
J Expo Sci Environ Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Reshetnikov, AV, Prisyazhnaya, et al |
Sotsiologicheskie Issledovaniya |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Decision-making About Risk in the Era of the Novel Coronavirus Disease |
Reyna, VF |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rhode, B |
Survival |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Letter: population mortality from COVID-19 and latitude—data from China. Authors' reply |
Rhodes, JM, Subramanian, et al |
Alimentary Pharmacology and Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rizvi, F |
Higher Education Research and Development |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Radical incrementalism and trust in the citizen: Income security in Canada in the time of COVID-19 |
Robson, J |
Canadian Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Care for institutionalized
older people during the COVID-19 pandemic: The most vulnerable |
Rodrigo, AP |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID has killed more than one million people. How many more will die? |
Rodríguez Mega, E |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rodriguez, M |
Social Work Education |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Promoting resiliency in adolescents during a pandemic: A guide for clinicians and parents |
Rome, ES, Dinardo, et al |
Cleve Clin J Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Coronavirus Disease 2019 as an Opportunity to Move toward Transdisciplinary Palliative Care |
Rosa, WE, Anderson, et al |
J Palliat Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Leveraging nurse practitioner capacities to achieve global health for all: COVID-19 and beyond |
Rosa, WE, Fitzgerald, et al |
Int Nurs Rev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Rosen, B, Preisman, et al |
Am J Psychother |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Roskos, M |
Klinikarzt |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Remdesivir emergency approvals: a comparison of the U.S., Japanese, and EU systems |
Saint-Raymond, A, Sato, et al |
Expert Rev Clin Pharmacol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The coronavirus (COVID-19) pandemic: challenges among Iranian startups |
Salamzadeh, A, Dana, et al |
Journal of Small Business and Entrepreneurship |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Private Video Consultation Services and the Future of Primary Care |
Salisbury, C, Quigley, et al |
J Med Internet Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Salluh, JIF, Lisboa, et al |
Crit Care |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Scientific dissemination
of the new SARS-CoV-2 coronavirus from the clinical laboratory |
San Miguel Hernández, Á, San Miguel Rodríguez, et al |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19 and youth sports: Psychological, Developmental, and Economic Impacts |
Sanderson, J, Brown, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sanghai, N, Tranmer, et al |
Drug discovery today |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Saputra, DEE, Eliyana, et al |
Systematic Reviews in Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Sasangohar, F, Bradshaw, et al |
J Med Internet Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Schallhorn, C, Kunert, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Reversible Myoclonus-Ataxia as a Postinfectious Manifestation of COVID-19 |
Schellekens, MMI, Bleeker-Rovers, et al |
Movement Disorders Clinical Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Possible Role of ABCB1 in Lysosomal Accumulation of Azithromycin in COVID-19 Therapy |
Scherrmann, JM |
Clinical pharmacology and therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Schlichtiger, J, Steffen, et al |
J Sports Med Phys Fitness |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Schlom, J, Donahue, et al |
J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Schneider, BC, Schneider, et al |
Nurs Manage |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32846454; Which protective mask protects against COVID-19? What is evidence-based? |
Schulze-Röbbecke, R, Reska, et al |
Aktuelle Rheumatologie |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Segalo, P, Fine, et al |
Social and Personality Psychology Compass |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Selway, WG, Stenson, et al |
Br J Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32935910; Onychomadesis following COVID-19 infection: Is there a relationship? |
Senturk, N, Ozdemir, et al |
Dermatologic Therapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Culture as care: Argentina’s cultural policy response to Covid-19 |
Serafini, P, Novosel, et al |
Cultural Trends |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Opsoclonus myoclonus ataxia syndrome (OMAS) in the setting of COVID-19 infection |
Shah, PB, Desai, et al |
Neurology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Shah, SGS, Awais, et al |
Ann Med Surg (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shahid, A, Javed, et al |
Int J Gynaecol Obstet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32925134; The role of Yoga in working from home during the COVID-19 global lockdown |
Sharma, K, Anand, et al |
Work (Reading, Mass.) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Special Issue on COVID-19 and Pregnancy: Consequences for Maternal and Neonatal Health |
Sharma, S, Burd, et al |
Am J Reprod Immunol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The social media response from athletes and sport organizations to COVID-19: An altruistic tone |
Sharpe, S, Mountifield, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Is cesarean section a
safe delivery method to prevent mother to child transmission of SARS-CoV-2? |
Shaterian, N, Abdi, et al |
Tehran University Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The cost of coronavirus obligations: Respecting the letter and spirit of lockdown regulations |
Shaw, D |
Camb Q Healthc Ethics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Working in a bubble: How can businesses reopen while limiting the risk of COVID-19 outbreaks? |
Shaw, J, Day, et al |
Cmaj |
Commentary/Editorial| Commentaire/Éditorial |
|
|
When sport event work stopped: Exposure of sport event labor precarity by the COVID-19 pandemic |
Sheptak, RD, J, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sherly Deborah, G, Archana, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shin, HS |
Infection and Chemotherapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Possible Double-Edged Sword Effects of Vitamin D on COVID-19: A Hypothesis |
Shojaeefar, E, Malih, et al |
Cell Biol Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Shojaei, H, Ehteshami, et al |
J Neurosurg Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shrestha, N, Pandey, et al |
Journal of Nepal Health Research Council |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Shrestha, S |
Journal of Nepal Health Research Council |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32955902; Dental treatment recommendations and coronavirus disease 19 (COVID-19) |
Siebert, T, Janickova, et al |
Bratislavske lekarske listy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Variability of symptoms in neuralgic amyotrophy following infection with SARS-CoV-2 |
Siepmann, T, Kitzler, et al |
Muscle Nerve |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Simon, PD |
Int J Soc Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Mobile Laboratory Routing Problem for COVID-19 Testing Considering Limited Capacities of
Hospitals |
Singgih, IK |
IEEE Electrification Magazine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
PMC7523746; Rhabdomyolysis in COVID-19: Report of Four Cases |
Singh, B, Kaur, et al |
Cureus |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Skevaki, C, Karsonova, et al |
J Allergy Clin Immunol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Impact of the coronavirus pandemic on the life of arctic regions in population estimates |
Sleptsov, AN, Potravnaya, et al |
Sotsiologicheskie Issledovaniya |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A post-COVID-19 lifestyle sport research agenda: Communication, risk, and organizational challenges |
Smith, WR |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
No Systemic Lupus Erythematosus with COVID-19 in Hong Kong: The Effect of Masking? |
So, H, Mak, et al |
J Rheumatol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Son, S, Williams, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The Author's Response: COVID-19 Antibody Test at Population Level: Why Timing Is the Key |
Song, SK, Lee, et al |
J Korean Med Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Sorrentino, RM, DiCola, et al |
J Am Acad Psychiatry Law |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Spinola, SM, Zimet, et al |
J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Managing Lung Nodules Using Telemedicine and Molecular Biomarkers During the COVID-19 Pandemic |
Springmeyer, SC, Jett, et al |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Srirengalakshmi, M, Venugopal, et al |
Journal of clinical orthodontics : JCO |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Staes, CJ, Jellison, et al |
J Am Med Inform Assoc |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Staurowsky, EJ, Koch, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Steinberg, DM, Schneider, et al |
Clinical Practice in Pediatric Psychology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Current and COVID-19 Challenges With Childhood and Adolescent Sleep |
Stern, M, Wagner, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
COVID-19: A Catalyst to Accelerate Global Regulatory Transformation |
Stewart, J, Honig, et al |
Clin Pharmacol Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Stoeklé, HC, Hervé, et al |
Canadian Journal of Bioethics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Aging in America: How COVID-19 Will Change Care, Coverage, and Compassion |
Sullivan-Marx, E |
Nursing outlook |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32970543; Migrant Workers at Crossroads–The Covid-19 Pandemic and the Migrant Experience in
India |
Suresh, R, James, et al |
Social Work in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Suzuki, K |
Rinsho Shinkeigaku |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Tailor, IK, Alshehry, et al |
Hematology/ Oncology and Stem Cell Therapy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32531225; Protecting the Homeless During the COVID-19 Pandemic |
Tan, LF, Chua, et al |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Tan, LF, Ho Wen Teng, et al |
Geriatr Gerontol Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32931775; The association between corticosteroid uses and mortality among severe COVID-19 patients |
Tang, HJ, Lai, et al |
Journal of Infection |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Neurological manifestations in COVID-19 and its possible mechanism |
Tang, X, Luo, et al |
Aging (Albany NY) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Taxt, AM, Grødeland, et al |
Tidsskr Nor Laegeforen |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Thapa, SB, Kakar, et al |
JAMA Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The, Lancet |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Timmis, K |
Environ Microbiol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Tozzi, P, Kampouri, et al |
Circ Cardiovasc Imaging |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Trogisch, S, Albert, et al |
Ecology and Evolution |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Tutusaus, A, Marí, et al |
Cells |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Blood and marrow transplantation during the emerging COVID-19 pandemic: the Seattle approach |
Ueda Oshima, M, Sandmaier, et al |
Bone marrow transplantation |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Finland's handling of selenium is a model in these times of coronavirus infections |
Ulfberg, J, Stehlik, et al |
Br J Nutr |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Covid-19 Pandemia Onset Anorexia Nervosa: 3 Adolescent Cases |
Ünver, H, Rodopman Arman, et al |
Psychiatry Clin Neurosci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Valeras, AS |
Families, Systems and Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Symptoms of a broken system: the gender gaps in COVID-19 decision-making |
van Daalen, KR, Bajnoczki, et al |
BMJ Glob Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Van Den Ende, L, Van Den Galien, et al |
Pharmaceutisch weekblad |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
COVID-19: Technology-Supported Remote Assessment of Pediatric Asthma at Home |
van der Kamp, MR, Tabak, et al |
Frontiers in Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Revisiting safe airway management and patient care by anaesthetists during the COVID-19 pandemic |
Van Zundert, TCRV, Barach, et al |
British journal of anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Vandamme, F |
Wisdom |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Vandenbroucke, JP, Brickley, et al |
Epidemiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
The agricultural policy trilemma: On the wicked nature of agricultural policy making |
Vik, J |
Land Use Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Volmink, J |
South African Journal of Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Wadia, R |
British dental journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Walke, HT, Honein, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Guidance on the use of biologic agents in psoriatic patients during COVID-19 outbreak |
Wang, G, Gu, et al |
Chinese Journal of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wang, J, Meng, et al |
J Mol Cell Biol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
How to perform safe laparoscopic extraction of surgical specimen during the COVID-19 era |
Wang, K, Alam, et al |
Ann R Coll Surg Engl |
Commentary/Editorial| Commentaire/Éditorial |
|
|
A Preventive Role of Exercise Across the Coronavirus 2 (SARS-CoV-2) Pandemic |
Wang, M, Baker, et al |
Frontiers in Physiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The impact of health QR code system on older people in China during the COVID-19 outbreak |
Wang, T, Jia, et al |
Age Ageing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wang, Yeming, Gu, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
American pentecostalism, the 8:46 moment, and the covid-19 pandemic |
Wariboko, N, Oliverio, et al |
Pneuma |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The Management of COVID-19 in Forensic Psychiatric Institutions |
Wasser, T, Hauser, et al |
Psychiatr Serv |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Weiss, RL, Kennell, et al |
J Nurses Prof Dev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Addressing mental health in patients and providers during the COVID-19 pandemic |
Werner, EA, Aloisio, et al |
Seminars in perinatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Werthmann, PG, Riley, et al |
The Permanente journal |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Everyday things change: Australian athlete communication during the coronavirus lockdown |
Whales, L, Frawley, et al |
International Journal of Sport Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wilson, DB, Solomon, et al |
Social Work in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Optimizing care for patients with interstitial lung disease during the COVID-19 pandemic |
Wong, AW, Shapera, et al |
Canadian Journal of Respiratory, Critical Care, and Sleep Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Place and causes of acute cardiovascular mortality during the COVID-19 pandemic |
Wu, J, Mamas, et al |
Heart |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Time Course of a Second Outbreak of COVID-19 in Beijing, China, June-July 2020 |
Wu, Z, Wang, et al |
JAMA - Journal of the American Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Elevated mortality of chronic diseases during COVID-19 pandemic: a cause for concern? |
Xia, Y, Li, et al |
Therapeutic Advances in Chronic Disease |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Depressive symptoms in students during school closure due to COVID-19 in Shanghai |
Xiang, M, Yamamoto, et al |
Psychiatry Clin Neurosci |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Captisol and GS-704277, but not GS-441524, are credible mediators of remdesivir's nephrotoxicity |
Yan, VC, Muller, et al |
Antimicrob Agents Chemother |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Yan, XK, Ma, et al |
World Chinese Journal of Digestology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yang, C, Li, et al |
EBioMedicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yates, TA, Cooke, et al |
F1000Research |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yeoh, DK, Foley, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Yin, Y |
IEEE Electrification Magazine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zacharowski, K |
Anaesthesist |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
A rise in facial nerve palsies during the coronavirus disease 2019 pandemic |
Zammit, M, Markey, et al |
J Laryngol Otol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zarranz, ARA |
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zeneli, A, Altini, et al |
Int Nurs Rev |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Reply to Sharma and Zeki: Does Vaping Increase Susceptibility to COVID-19? |
Zhang, H, Rostamim, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zhang, J |
Transp Policy (Oxf) |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zhang, N, Chan, et al |
Headache |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zhao, H, Mendenhall, et al |
Leukemia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zhao, Y, He, et al |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zheng, KI, Rios, et al |
Frontiers in Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Quarantine Life Is Stillness and Dialogue: A Reflective Autoethnography During a Global Pandemic |
Zheng, S |
Qualitative Inquiry |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Zhou, Z, Gao, et al |
Frontiers in Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zhu, H, John-Legere, et al |
Arch Dis Child Educ Pract Ed |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Zimmerman, A |
Transpl Int |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Obesity |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Obesity |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Journal of Molecular Diagnostics |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Progress in Disaster Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Revista espanola de cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
The Lancet Rheumatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
The Lancet Rheumatology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Infection control and hospital epidemiology |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
32968263; Unsustainable charcoal, COVID spreads on plane and antibody cocktails |
|
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Daten unterstreichen: Kein absetzen der therapie aus angst vor sars-cov-2 |
|
Aktuelle Rheumatologie |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Cardiovasc Res |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Science |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Texto e Contexto Enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
J Am Soc Nephrol |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Perfiles Educativos |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Eurosurveillance |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Systematic Reviews in Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
|
Gaceta Medica de Bilbao |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
revisiting safe airway management and patient care by anaesthetists during
the COVID-19 pandemic |
|
J Nucl Med |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
R I Med J (2013) |
Commentary/Editorial| Commentaire/Éditorial |
|
Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans and activities by collaborators. Members of the Emerging Sciences group examine and shorten the abstract or develop 1 -2 point summaries of each publication. Please email Lisa
Waddell for additional information: Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely
to influence future results.
Epidemiology: the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health.
Includes Ro, attack rates, case number doubling time, case fatality rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host to an uninfected host via direct or indirect routes.
Clinical data of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well
as clinical profiles of patients; presenting symptoms, symptoms over course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed,
number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics: Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research: Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities: These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response: This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment
preparation/ stock piling supplies; Education and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Immunology: the study of the immune system and includes serology studies in conjunction with other foci (e.g. epidemiology or diagnostics)
Animal Model:
An animal model is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding
the disease process without the added risk of harming an actual human.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature: All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial: For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary
category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, et à des activités des collaborateurs.
Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction : La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats.
Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro),
les taux d'attaque, le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que
les profils cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé.
Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes : Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes,
etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Immunologie : l'étude du système immunitaire et comprend des études sérologiques en conjonction avec d'autres foyers (p. ex. épidémiologie ou diagnostic)
Modèle
animal:
Un modèle animal est un animal vivant, non humain, souvent génétiquement modifié, utilisé lors de la recherche et de l'investigation des maladies
humaines, dans le but de mieux comprendre le processus de la maladie sans risque supplémentaire de nuire à un humain réel.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial : Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune
analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des commentaires.
journaux Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives