Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19, 2020-09-29
Good morning,
There are 216 citations in today’s scan. 119 were considered primary research or review literature.
Highlights today include:
CANADA
·
Mrklas et al.
assessed the self-reported prevalence of stress, anxiety, depression, and obsessive-compulsive symptoms in health care workers and other workers seeking support through Text4Hope, an evidence-based SMS text messaging service supporting the mental health
of residents of Alberta, Canada, during the COVID-19 pandemic. In the general sample, the 6-week prevalence rates for moderate or high stress, anxiety, and depression symptoms were 85.6%, 47.0%, and 44.0%, respectively. Self-reported symptoms of moderate or
high stress, anxiety, and depression were all statistically significantly higher in other workers than in health care workers.
EPIDEMIOLOGY
·
Maghbooli et al. This study investigates the association between serum 25-hydroxyvitamin D levels
and its effect on adverse clinical outcomes, and parameters of immune function and mortality due to a SARS-CoV-2 infection. There was a significant association between vitamin D sufficiency and reduction in clinical severity, inpatient mortality serum levels
of C-reactive protein (CRP) and an increase in lymphocyte percentage. Vitamin D sufficiency also may help modulate the immune response possibly by reducing risk for cytokine storm in response to this viral infection.
CLINICAL DATA
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Cho et al
report a case of a 45 day old infant positive for COVID-19 with persistent fecal virus shedding for more than 12 weeks. This highlights the potential of fecal virus shedding as an important feature of viral transmission in infants and young children.
THERAPEUTICS
·
Gudmundsdottir et al
studied the efficacy of Coldzyme® oral spray against SARS-CoV-2 in vitro. Coldzyme inactivated SARS-CoV-2 by 98.3%. These results cannot be directly translated into clinical efficacy; however, the study indicates that Coldzyme might offer a protective
barrier against SARS-CoV-2 in the oral cavity.
·
Hong, et al.
present for the first time that SARS-CoV-2 pseudovirus and GX_P2V could infect lung progenitor and even anterior foregut endoderm cells causing these cells death, which differentiated from human embryonic stem cells (hESCs). The infection and replication
of SARS-CoV-2 and GX_P2V were inhibited when treated with whey protein of breastmilk and Remdesivir, confirming that these two viruses could infect lung progenitor and even anterior foregut endoderm.
·
Goren et al
conducted a prospective cohort study of 77 men. The proportion of subjects admitted to the ICU taking anti-androgens was significantly lower than those not taking anti-androgens (8% vs 58%). This association held in age-matched analysis. The relative
risk for ICU admission for subjects taking anti-androgens was 0.14 (95%CI: 0.02-0.94).
DIAGNOSTICS
·
Hubbard, et al.
collected samples from hospitalized inpatients with and without a confirmed SARS-CoV-2 infection, remnant clinical specimens collected and frozen prior to the COVID19 outbreak, and paired serum and plasma samples from convalescent plasma donors were
used to determine performance characteristics of the Abbott SARS-CoV-2 IgG and Roche Elecsys Anti-SARS-CoV-2 assays. Both the Abbott and Roche platforms offer excellent specificity but negative serologic results do not exclude previous SARS-CoV-2 infection.
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Kasetsirikul et al.
reported developing a rapid, inexpensive and straightforward colorimetric paper-based assay for the detection of SARS-CoV-2 humanized antibody.
PUBLIC HEALTH RESPONSE
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Niedzwiedz et al.
examined trends in mental health and health behaviours in the UK before and during the initial phase of the COVID-19 lockdown and differences across population subgroups. They found that psychological distress
increased 1 month into lockdown, particularly among women and young adults. Smoking declined, but adverse alcohol use generally increased.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Christina Bancej, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin
Young, Chatura Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Alex Gilbert, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
Anti-SARS-CoV-2 antibodies in the CSF, blood-brain barrier dysfunction, and neurological outcome: Studies in 8 stuporous and comatose patients |
Alexopoulos, H, Magira, et al |
Neurol Neuroimmunol Neuroinflamm |
Clinical data| Données cliniques Immunology | Immunologie |
This study aimed to investigate the pathophysiologic mechanism of encephalopathy and prolonged comatose or stuporous
state in severally ill patients with coronavirus disease 2019 (COVID-19). Eight COVID-19 patients with signs of encephalopathy were tested for antibodies to SARS-CoV-2. All patients had anti-SARS-CoV-2 antibodies in their CSF, and 4 of 8 patients had high
titers, comparable to high serum values. One patient had anti-SARS-CoV-2 IgG intrathecal synthesis, and 3 others had disruption of the blood-brain barrier. The CSF in 4 patients was positive for 14-3-3-protein suggesting ongoing neurodegeneration. In all patients,
the CSF was negative for autoimmune encephalitis antibodies and SARS-CoV-2 by PCR. None of the patients, apart from persistent encephalopathic signs, had any focal neurologic signs or history or specific neurologic disease. |
|
Anand, Shuchi, Montez-Rath, et al |
The Lancet |
Epidemiology| Épidémiologie Immunology | Immunologie |
For this cross-sectional study, in partnership with a central laboratory that receives samples from approximately 1300 dialysis facilities across the USA,
we tested the remainder plasma of 28 503 randomly selected adult patients receiving dialysis in July, 2020, using a spike protein receptor binding domain total antibody chemiluminescence assay (100% sensitivity, 99·8% specificity). Seroprevalence of SARS-CoV-2
was 8·0% (95% CI 7·7–8·4) in the sample, 8·3% (8·0–8·6) when standardised to the US dialysis population, and 9·3% (8·8–9·9) when standardised to the US adult population. When standardised to the US dialysis population, seroprevalence ranged from 3·5% (3·1–3·9)
in the west to 27·2% (25·9–28·5) in the northeast. |
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Older People's Non-Physical Contacts and Depression During the COVID-19 Lockdown |
Arpino, B, Pasqualini, et al |
Gerontologist |
Public Health response| Interventions de santé publique |
We examine to what extent intergenerational and other types of non-physical contacts have reduced the risk of increased perceived depressive feelings during
the lockdown for people aged 50+. About 50% of individuals aged 50+ felt sad or depressed more often than usual during the lockdown in the three considered countries. Older people who increased or maintained unchanged non-physical contacts with non-coresident
individuals during the lockdown were at a lower risk of increased perceived depressive feelings compared to those who experienced a reduction in non-physical contacts. The beneficial effect of non-physical contacts was stronger for intergenerational relationships.
The effects were similar by gender and stronger among individuals aged 70+, living in Spain and not living alone before the start of the lockdown. |
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ADPriboDB v2.0: An Updated Database of ADP-ribosylated
Proteins |
Ayyappan, Vinay, Wat, et al |
bioRxiv |
Coronavirology| Coronavirologie |
ADP-ribosylation is a protein modification responsible for biological processes such as DNA repair, RNA regulation, cell cycle, and biomolecular condensate
formation. Dysregulation of ADP-ribosylation is implicated in cancer, neurodegeneration, and viral infection. We developed ADPriboDB (adpribodb.leunglab.org) to facilitate studies in uncovering insights into the mechanisms and biological significance of ADP-ribosylation.
ADPriboDB 2.0 serves as a one-stop repository comprising 48,346 entries and 9,097 ADP-ribosylated proteins, of which 6,708 were newly identified since the original database release. In this updated version, we provide information regarding the sites of ADP-ribosylation
in 32,946 entries. The wealth of information allows us to interrogate existing databases or newly available data. For example, we found that ADP-ribosylated substrates are significantly associated with the recently identified human protein interaction networks
associated with SARS-CoV-2, which encodes a conserved protein domain called macrodomain that binds and removes ADP-ribosylation. In addition, we create a new interactive tool to visualize the local context of ADP-ribosylation, such as structural and functional
features as well as other post-translational modifications (e.g., phosphorylation, methylation and ubiquitination). This information provides opportunities to explore the biology of ADP-ribosylation and generate new hypotheses for experimental testing.Competing
Interest StatementThe authors have declared no competing interest. |
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Can children's oral hygiene and sleep routines be compromised during the COVID-19 pandemic? |
Baptista, AS, Prado, et al |
Int J Paediatr Dent |
Public Health response| Interventions de santé publique |
This cross-sectional study aimed to evaluate sleep disorders among Brazilian and Portuguese children during social distancing, and its association with
parental perception of child's oral hygiene. Participated in the study 253 parents/caregivers, 50.2% from Brazil. Most parents (72.2%) reported changes in child's routine during social distancing. Sleep-breathing disorders (P=0.019), sleep-wake transition
disorders (P=0.022) and disorders of excessive somnolence (P<0.001) were associated with poor oral hygiene during social distancing. |
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Bianco, M, Biolè, et al |
Int J Cardiol Heart Vasc |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Non-ICU hospitalized patients of the three centres involved in the study from the 19th of March to the 1st of May were
included in this retrospective multicentre study. 196 patients were analysed. 20 patients (10.2%) reached a QTc ≥ 500 ms. Patients with QTc ≥ 500 ms were significantly older (66.7 ± 14.65 vs 76.6 ± 8.77 years p: 0.004), with higher Tisdale score (low 56 (31.8%)
vs 0; intermediate 95 (54.0%) vs 14 (70.0%); high 25 (14.2%) vs 6 (30.0%); p: 0.007) and with higher prognostic lab values (d-dimer 1819 ± 2815 vs 11486 ± 38554 ng/ml p: 0.010; BNP 212.5 ± 288.4 vs 951.3 ± 816.7 pg/ml p < 0.001; procalcitonin 0.27 ± 0.74 vs
1.33 ± 4.04 ng/ml p: 0.003). After a multivariate analysis the Tisdale score was able to predict a QTc prolongation ≥ 500 ms (OR 1,358 95% CI 1,076-1,714p: 0,010). 27 patients died because of COVID-19 (13.7%), none experienced ventricular arrhythmias, and
2 (1.02%) patients with concomitant cardiovascular condition died of sudden death. |
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Bsteh, G, Bitschnau, et al |
Eur J Neurol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective was to determine the frequency and distribution of currently known risk factors for COVID-19 mortality
in a MS population. Of 1931 MS patients, 63.4% had low risk of COVID-19 mortality, 26% had mild risk, 8.8% had a moderate risk, while a combined 0.9% had high or very high risk of COVID-19 mortality. Of the patients at high or very high risk, only one patient
received DMT and none had an immunosuppressive therapy. |
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Outpatient COVID-19 Surveillance Testing in Orthotopic
Heart Transplant Recipients |
Carey, SA, Afzal, et al |
Clin Transplant |
Epidemiology| Épidémiologie Surveillance Immunology | Immunologie |
This study is an observational, retrospective analysis of a large cohort of post OHT patients in a high volume heart
transplantation program in Dallas, Texas that underwent outpatient COVID-19 screening and testing for both SARS-CoV-2 nasopharyngeal RT-PCR and anti-SARS-CoV2 IgG serology as a result of a clinic protocol to facilitate re-opening of face-to-face outpatient
clinical visits. The full outpatient cohort tested at time of their clinic visit tested negative for COVID-19 by nasopharyngeal RT-PCR. Only 2 patients tested seropositive for anti-SARS-COV2 IgG. Five positive inpatient cases were also identified and all,
but one has recovered. A COVID-19 surveillance protocol can be easily instituted in this high-risk population and facilitate safe transplant clinic operation. |
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Caricchio, R, Gallucci, et al |
Ann Rheum Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To develop predictive criteria for COVID-19-associated cytokine storm (CS). We analysed 513 hospitalised patients who
were positive for COVID-19. To achieve an early diagnosis, we analysed the laboratory results of the first 7 days of hospitalisation. We implemented logistic regression and principal component analysis to determine the predictive criteria. We used a 'genetic
algorithm' to derive the cut-offs for each laboratory result. We validated the criteria with a second cohort of 258 patients. We found that the criteria for macrophage activation syndrome, haemophagocytic lymphohistiocytosis and the HScore did not identify
the COVID-19 cytokine storm (COVID-CS). We developed new predictive criteria, with sensitivity and specificity of 0.85 and 0.80, respectively, comprising three clusters of laboratory results that involve (1) inflammation, (2) cell death and tissue damage,
and (3) prerenal electrolyte imbalance. The criteria identified patients with longer hospitalisation and increased mortality. These results highlight the relevance of hyperinflammation and tissue damage in the COVID-CS. |
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Cyclooxgenase-2
is induced by SARS-CoV-2 infection but does not affect viral entry or replication |
Chen, JenniferS, Alfajaro, et al |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
The purpose of this study was to dissect the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on COVID-19 in
terms of SARS-CoV-2 entry and replication. We found that SARS-CoV-2 infection induced COX-2 upregulation in diverse human cell culture and mouse systems. However, suppression of COX-2/PGE2 signaling by two commonly used NSAIDs, ibuprofen and meloxicam, had
no effect on ACE2 expression, viral entry, or viral replication. Our findings suggest that COX-2 signaling driven by SARS-CoV-2 may instead play a role in regulating the lung inflammation and injury observed in COVID-19 patients. Public health officials have
raised concerns about the use of NSAIDs for treating symptoms of COVID-19. While COX-1/COX-2 signaling pathways have been shown to affect the replication of many viruses, their effect on SARS-CoV-2 infection remains unknown. We found that SARS-CoV-2 infection
induced COX-2 expression in both human cell culture systems and mouse models. However, inhibition of COX-2 activity with NSAIDs did not affect SARS-CoV-2 entry or replication. Our findings suggest that COX-2 signaling may instead regulate the lung inflammation
observed in COVID-19 patients. |
|
Chen, KL, Hung, et al |
Hu Li Za Zhi |
Public Health response| Interventions de santé publique |
This study was designed to explore the related changes in daily life and impacts on the well-being of a group of patients
with chronic treatment-resistant depression (TRD) during the COVID-19 pandemic. All of the subjects who were diagnosed with major depression and fit the inclusion criteria were referred by the psychiatrists from two teaching hospitals. Structured interviews
were used to collect data on physical and psychological changes during the pandemic period between January and May 2020. The 116 respondents revealed that the COVID-19 pandemic affected their health in the biological, psychological, and social dimensions.
The three emerging themes included: The threatening of homogeneity in the whole person's health, the interaction between bio-psycho-social aspects, and positive growth of individuals with TRD. Although the participants had confidence in the prevention strategies
of the government related to COVID-19, they expressed feelings of distress and restlessness with regard to COVID-19-related news reports. |
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Cho, SM, Ha, et al |
Yonsei Med J |
Clinical data| Données cliniques |
In this report, we describe the case of a SARS-CoV-2 infection (COVID-19) in an infant with mild fever and diarrhea
in the absence of respiratory distress. A 45-day-old male infant with COVID-19 was transferred to our pediatric department. He had mild fever and diarrhea at admission. Positive-to-negative nasal swab conversion occurred on the 21st day from the onset of symptoms.
However, stool swab positivity persisted during the 6-week admission period and for 7 weeks during follow-up at an outpatient clinic after discharge. Negative conversion in a stool specimen occurred on the 142nd day from the onset of symptoms. This case highlights
the potential of fecal virus shedding as an important feature of viral transmission in infants and young children. |
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Effect of Asthma and Asthma Medication on the Prognosis
of Patients with COVID-19 |
Choi, YJ, Park, et al |
Eur Respir J |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study examines the effects of asthma, asthma medication, and asthma severity on the clinical outcomes of COVID-19
have not yet been established. Among 7590 COVID-19 patients, 218 (2.9%) had underlying asthma. The total medical cost associated with COVID-19 patients with underlying asthma was significantly higher than that of other patients. Mortality rate for COVID-19
patients with underlying asthma (7.8%) was significantly higher than that of other patients (2.8%; p<0.001). However, asthma was not an independent risk factor for the clinical outcomes of COVID-19 after adjustment. Asthma medication use and asthma severity
also did not affect the clinical outcomes of COVID-19. However, use of oral short-acting β(2)-agonists (SABA) was an independent factor to increase the total medical cost burden. Patients with step 5 asthma showed significant prolonged admission duration than
those with step 1 asthma in both univariate and multivariate analysis. |
|
Conroy, DA, Hadler, et al |
J Clin Sleep Med |
Healthcare Response | Réponse des soins de santé |
A cross-sectional online survey administered to health care workers. The survey assessed changes in sleep, work, screen
time, media exposure, diet, exercise, substance use, and mood. The survey data was collected between March 28, 2020, and April 29, 2020. A total of 834 of 936 individuals completed the entire survey. Respondents were from 41 US states. Mood after the stay-at-home
orders worsened and screen time and substance use increased. Total sleep time (TST) shortened in those continuing to work in-person (p<.001), whereas TST was unchanged in those working from home (p=.73). Those working from home went to bed later, woke up later,
and worked fewer hours. Reduced TST and increased screen time before bed were associated with worse mood and screen time. Longer sleep time was associated with better mood. |
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Di Mascio, D, Sen, et al |
J Perinat Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Evaluated the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal
outcomes in pregnancies with laboratory confirmed COVID-19. 8.0% of women were diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal
deaths, with an overall rate of perinatal death of 4.2% (11/265). Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at
arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The newborn was asymptomatic and had negative
RT-PCR test after 14 days of life. |
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No SARS-CoV-2 antibody response in 25 patients with pseudo-chilblains |
Docampo-Simón, A, Sánchez-Pujol, et al |
Dermatol Ther |
Clinical data| Données cliniques |
Chilblain-like acral lesions have been identified in some COVID-19 patients. It has been suggested that these pseudo-chilblains
could be a specific marker of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Most patients with these lesions have had negative PCRs, but some authors believe serology tests are likely to give positive results. We designed a prospective
study including all patients with pseudo-chilblains treated in out department in April and May 2020 then performed SARS-CoV-2 PCR and serology tests on all available patients. We evaluated 59 patients, of whom 17 had undergone PCR before the study period,
all with negative results. For the present study, we performed 20 additional PCRs, serology tests in 25 patients, and a parvovirus B19 antibody test in 15 patients. All results were negative. Our findings counter the hypothesis that serology is likely to reveal
SARS-CoV-2 infection in patients with pseudo-chilblains. One hypothesis for our negative results is that the time period between symptom onset and antibody production is longer in these patients; another is that the lesions are caused by behavioural changes
during lockdown rather than SARS-CoV-2 infection. We nevertheless maintain that COVID-19 should be ruled out in people presenting with chilblain-like lesions. This article is protected by copyright. All rights reserved. |
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D'Orazio, Marco, Bernardini, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
This work proposes a quick and probabilistic simulation model based on consolidated proximity and exposure-time-based
rules for virus transmission (confirmed by international health organizations). The building occupancy is defined according to university schedule, identifying the main “attraction areas” in the building (classrooms, break-areas). Scenarios are defined in
terms of occupants’ densities, mitigation strategies, virus-related aspects. The model is calibrated on experimental data and applied to a relevant university building. Results demonstrate the model capabilities. In the case study, occupants’ capacity limitation
could support the adoption of surgical masks by users instead of FFPk masks (thus improving users’ comfort issues). Preliminary correlations to combine acceptable mask filters-occupants’ density are proposed to support stakeholders in organizing users’ presences
in the building during the pandemic. |
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Fagre, AnnaC, Manhard, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique Animal model | Modèle animal |
The emergence of COVID-19 has led to a pandemic that has caused millions of cases of disease, variable morbidity and
hundreds of thousands of deaths. Currently, only remdesivir and dexamethasone have demonstrated limited efficacy, only slightly reducing disease burden, thus novel approaches for clinical management of COVID-19 are needed. We identified a panel of human monoclonal
antibody clones from a yeast display library with specificity to the SARS-CoV-2 spike protein receptor binding domain that neutralized the virus in vitro. Administration of the lead antibody clone to Syrian hamsters challenged with SARS-CoV-2 significantly
reduced viral load and histopathology score in the lungs. Moreover, the antibody interrupted monocyte infiltration into the lungs, which may have contributed to the reduction of disease severity by limiting immunopathological exacerbation. The use of this
antibody could provide an important therapy for treatment of COVID-19 patients.Competing Interest StatementSeveral authors of this manuscript are employees of AvantGen, Inc., the developers of the monoclonal antibody described in this study. |
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PMC7447211; Acute reversible renal failure requiring temporary dialysis in a patient
with COVID-19 |
Faqeeh, S, Madkhali, et al |
Radiol Case Rep |
Clinical data| Données cliniques |
COVID-19 infection is associated with increased risk of acute kidney injury, but the imaging changes of the kidneys
are not fully investigated yet. We report the computed tomography findings in a 17-year-old male who developed severe reversible renal impairment. Those findings are similar to the changes observed in patients with vasculitis and can be contributed to the
thromboembolic manifestations associated with corona virus infection. |
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The impact of the COVID-19 pandemic on the perinatal mental health of women |
Farrell, T, Reagu, et al |
J Perinat Med |
Public Health response| Interventions de santé publique |
Examined the impact of the COVID-19 pandemic and related restrictions on perinatal mental health among women in Qatar.
The survey results revealed a high prevalence of anxiety and Depressive symptomatology (34.4 and 39.2% respectively). These rates appeared much higher than the reported pre-pandemic prevalence and were not affected by occupation, previous mental health problems
or pregnancy complications. |
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Effects of lockdown on health of patients with severe atopic dermatitis treated with dupilumab |
Ferrucci, SM, Tavecchio, et al |
J Eur Acad Dermatol Venereol |
Public Health response| Interventions de santé publique |
Describe our experience in the Dermatology Unit of our hospital in Milan, observing how lockdown period influenced
clinical and psychological aspects of patient with severe atopic dermatitis (AD) in therapy with dupilumab. Our data shows a paradoxical effect: a marked AD clinical improvement (with calculated Eczema Area and Severity Index (EASI) decreasing 23% on average)
with a decline in the psychological scores (Hospital Anxiety and Depression Scale for depression (HADS-D) score declined by 23%). Worsening of psychological scores may be explained by the confinement in households with less recreational activities, fear of
contagion and loss of positive vision for the future. |
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Fisher, JC, Tomita, et al |
Ann Surg |
Healthcare Response | Réponse des soins de santé |
In the context of state-mandated controls and public wariness of hospitals, we investigated the impact of the COVID-19
outbreak on perforated appendicitis in children. Compared to a 5-year control cohort, we observed a higher perforation rate (45% vs 27%) and longer mean duration of symptoms in children with perforations (71 ± 39 vs 47 ± 27 h, P = 0.001) during the COVID-19
period. There were no differences in perforation rates (55% vs 59%, P = 0.99) or median length of stay (1.0 vs 3.0 days, P = 0.58) among children screening positive or negative for SARS-CoV-2. |
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COVID-19 pandemic lockdown and problematic eating behaviors in a student population |
Flaudias, V, Iceta, et al |
J Behav Addict |
Public Health response| Interventions de santé publique |
Examined the relationships between stress related to lockdown measures and binge eating and dietary restriction in
a population of French students during the first week of confinement. Stress related to the lockdown was associated with greater likelihood of binge eating and dietary restriction over the past week and intentions to binge eat and restrict over the next 15
days. Greater exposure to COVID-19-related media was associated with increased eating restriction over the past week. Binge eating and restriction (past and intentions) were associated with established risk factors, including female gender, low impulse regulation,
high body dissatisfaction, and having a concurrent probable eating disorder. |
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Fortini, A, Beltrame, et al |
Pol Arch Intern Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The main objectives of the study were to assess the values of inflammatory and some coagulation parameters and the
rate of venous thromboembolism (VTE) in patients with COVID-19 hospitalized in a non-ICU medical ward and to compare the characteristics of patients with mild disease with those with moderate and severe disease. The rate of VTE was remarkably high in patients
with COVID-19 admitted to a non-intensive care unit. The great majority of these patients, even those with mild disease, show a profound alterations of the inflammatory and of some coagulation markers. |
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Oral favipiravir for patients with delayed SARS-CoV-2 viral RNA clearance: a case
series |
Fu, D, Cao, et al |
Crit Care |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Here, we report a series of patients with considerably delayed SARS-CoV-2 RNA clearance and the treatment efficacy
of favipiravir in this population. The median duration of positive detection of SARS-CoV-2 viral RNA in patients before the initiation of favipiravir treatment was 61.0 days (IQR 52.8-67.3 days). After initiation of favipiravir, the median duration of viral
shedding was 3 days (IQR 2-6) and one patient remained SARS-CoV-2 RNA-positive after 14 days. Notably, seven of eight patients showed a rapid viral clearance within 6 days. Our study suggests that favipiravir is worth further investigation as a common and
widely used method of treating asymptomatic convalescent patients and carriers. |
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Fumagalli, C, Rozzini, et al |
BMJ Open |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective cohort study, we aimed to develop a clinical risk score to predict the in-hospital mortality
in COVID-19 patients in Italy, based on a set of variables available soon after the hospitalisation triage. Using Cox regression analysis, tertiles of increasing age, and number of chronic diseases, respiratory rate, PaO(2)/FiO(2), serum creatinine and platelet
count were predictors of mortality. All six predictors were used to build the COVID-19 mortality risk score, which proved to be highly accurate in stratifying patients at low, intermediate and high risk of in-hospital death . |
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Goren, A, Wambier, et al |
J Eur Acad Dermatol Venereol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
A prospective cohort study was conducted from the data of men hospitalized due to COVID-19 followed in an observational
genetic case-control study. The proportion of subjects admitted to the ICU taking anti-androgens was significantly lower than those not taking anti-androgens (8% vs 58%). This association held in age-matched analysis. The relative risk for ICU admission for
subjects taking anti-androgens 0.14 (95%CI: 0.02-0.94). These findings suggest that anti-androgens may represent a promising treatment modality for COVID-19. |
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COVID-19: Forecasting mortality given mobility trend data and non-pharmaceutical interventions |
Grisales Diaz, Victor Hugo, Prado-Rubio, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission
Public health interventions*| Interventions de santé publique |
We develop a novel hybrid epidemiological model and a specific methodology for its calibration to distinguish and assess
the impact of mobility restrictions (given by Apple's mobility trends data) from other complementary non-pharmaceutical interventions (NPIs) used to control the spread of COVID-19. Using the calibrated model, we estimate that mobility restrictions contribute
to 47 % (US States) and 47 % (worldwide) of the overall suppression of the disease transmission rate using data up to 13/08/2020. A four week ahead forecast of the number of deceased individuals and cumulative confirmed cases has a mean absolute percentage
error of 3.6 ± 0.9% and 10.6 ± 2.9 %, respectively. |
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Gudmundsdottir, Á, Scheving, et al |
J Med Virol |
Therapeutics| Thérapeutique |
In this study, the efficacy of ColdZyme® (CZ-MD), a medical device mouth spray, was tested against SARS-CoV-2 and HCoV-229E
in vitro. CZ-MD inactivated SARS-CoV-2 by 98.3%. Although the in vitro results presented cannot be directly translated into clinical efficacy, the study indicates that CZ-MD might offer a protective barrier against SARS-CoV-2 and a decreased risk of COVID-19
transmission. |
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PMC7491416; The Impact of COVID-19 pandemic on pediatric surgery practice: A cross-sectional
study |
Gunadi, Idham, Y, et al |
Ann Med Surg (Lond) |
Healthcare Response | Réponse des soins de santé |
We aimed to compare pediatric surgery practices, including the number and types of surgery, either elective or emergency
surgeries and outpatient services, before the outbreak and during the COVID-19 pandemic in our institution. The frequency of elective surgeries during the pandemic was lower than during the last three months before the outbreak. No laparoscopic procedures
were performed during the pandemic compared with 16 in the one-year period before the outbreak. The frequency of pediatric procedures was similar before and after. A declining trend was apparent in the outpatient services. |
|
He, W, Guo, et al |
ACS Nano |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Comprehensive experiments regarding filtering facepiece respirators (FFRs) regeneration were performed in this study
with model bacteria to illustrate the decontamination performance of the regeneration processes. The results showed that it is dangerous to use a contaminated FFR without any microbe inactivation treatment because the bacteria can live for more than 8 hours.
UVI+MWI and steam were recommended to effectively decontaminate the used respirators and still maintain the respirators’ filtration efficiency. |
|
|
Heberto, AB, Carlos, et al |
Int J Cardiol Heart Vasc |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
An observational, longitudinal, prospective, and multicenter study of hospitalized Mexican patients was made. We assessed
the prevalence of myocardial injury and its relationship with complications and mortality. We found myocardial injury represents an increased risk of complications and death in Mexican hospitalized patients with COVID-19. |
|
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Presence of hyaluronan in lung alveoli in severe Covid-19 - an opening for new treatment
options? |
Hellman, U, Karlsson, et al |
J Biol Chem |
Clinical data| Données cliniques |
The aim of the study was to demonstrate if the lungs of fatal Covid-19 contain hyaluronan as it is associated with
inflammation and acute respiratory distress syndrome (ARDS) and may have the appearance of liquid jelly. This is the first study to confirm prominent hyaluronan exudates in the alveolar spaces of Covid-19 lungs, supporting the notion that the macromolecule
is involved in ARDS caused by SARS-CoV-2. The present finding may open up for new treatment options in severe Covid-19, aiming at reducing the presence and production of hyaluronan in the lungs. |
|
Hoel, H, Heggelund, et al |
J Intern Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We hypothesized that gut leakage of microbial products, and subsequent inflammasome activation could contribute to
cardiac involvement in COVID‐19 patients. Patients with cardiac involvement had elevated markers of gut leakage and inflammasome activation, suggestive of a potential gut‐heart axis in COVID‐19. |
|
|
Hong, Bixia, Lai, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here we present for the first time that SARS-CoV-2 pseudovirus and GX_P2V could infect lung progenitor and even anterior
foregut endoderm cells causing these cells death, which differentiated from human embryonic stem cells (hESCs). The infection and replication of SARS-CoV-2 and GX_P2V were inhibited when treated with whey protein of breastmilk and Remdesivir, confirming that
these two viruses could infect lung progenitor and even anterior foregut endoderm. |
|
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Comparison of two automated immunoassays for the detection of SARS-CoV-2 nucleocapsid
antibodies |
Hubbard, JA, Geno, et al |
J Appl Lab Med |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Samples collected from hospitalized inpatients with and without a confirmed SARS-CoV-2 infection, remnant clinical
specimens collected and frozen prior to the COVID19 outbreak, and paired serum and plasma samples from convalescent plasma donors were used to determine performance characteristics of the Abbott SARS-CoV-2 IgG and Roche Elecsys Anti-SARS-CoV-2 assays. Both
the Abbott and Roche platforms offer excellent specificity but negative serologic results do not exclude previous SARS-CoV-2 infection. |
|
COVID-19: Belize's Success Story in Containing Community Spread Has Suffered a Setback! |
Husaini, DC, Abubakar, et al |
Asia Pac J Public Health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique
Public Health response| Interventions de santé publique |
This article presents some of the earlier measures put in place by the government of Belize that effectively curbed
the community spread of COVID-19 in the country of Belize. Effective community participation is still the most effective means of preventing COVID-19 spread. New COVID-19 cases are being reported in Belize after successful control, as a result of illegal border
crossing, repatriations of Belizeans abroad, and the apparent lack of adherence to the earlier measures put in place by the government to curb community spread of the COVID-19. |
|
Impending Central Retinal Vein Occlusion in a Patient with Coronavirus Disease
2019 (COVID-19) |
Invernizzi, A, Pellegrini, et al |
Ocul Immunol Inflamm |
Clinical data| Données cliniques |
We report a case of impending central retinal vein occlusion (iCRVO) in a COVID-19 patient. Systemic treatment with
steroids normalized her inflammatory and coagulation status and the occlusion completely resolved. |
|
Islam, JY, Camacho-Rivera, et al |
Cancer Epidemiol Biomarkers Prev |
Public Health response| Interventions de santé publique |
We evaluated COVID-19-related preventive behaviors among cancer survivors in the United States (US). Cancer survivors
were more likely to practice preventive behaviors, including social distancing, wear a face mask, and avoid crowded areas compared to other adults. Cancer survivor's continuity of care may be impacted by COVID-19 specifically young adults, females, and those
with existing comorbid conditions. |
|
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Clinical Mortality in a Large COVID-19 Cohort: Observational Study |
Jarrett, M, Schultz, et al |
J Med Internet Res |
Clinical data| Données cliniques |
We describe the demographic characteristics of patients who died of COVID-19, observation of frequent rapid response
team/cardiac arrest (RRT/CA) calls for non-intensive care unit (ICU) patients, and factors that contributed to RRT/CA calls. Of 2634 patients who died of COVID-19, 1478 (56.1%) had oxygen saturation levels ≥90% on presentation and required no respiratory support.
At least one RRT/CA was called on 1112/2634 patients (42.2%) at a non-ICU level of care. Before the RRT/CA call, the most recent oxygen saturation levels for 852/1112 (76.6%) of these non-ICU patients were at least 90%. At the time the RRT/CA was called, 479/1112
patients (43.1%) had an oxygen saturation of <80%. |
|
Jian, M, Liang, et al |
J Neurosurg Anesthesiol |
Healthcare Response | Réponse des soins de santé |
We retrospectively reviewed the clinical data of patients undergoing neurosurgical and neurointerventional procedures
at Beijing Tiantan Hospital, China during the early stages of the COVID-19 pandemic between January 21 and July 31, 2020. A total of 4025 patients underwent neurosurgery during the study period. Forty-five patients were diagnosed with COVID-19 and transferred
to the COVID-19 designated hospital. There were no cases of COVID-19 nosocomial infections among surgical patients or health care workers. |
|
|
Discordance between Serum Neutralizing Antibody Titers
and the Recovery from COVID-19 |
Kalkan Yazıcı, M, Koç, et al |
J Immunol |
Clinical data| Données cliniques Immunology | Immunologie |
In the current study, we set out to investigate neutralizing Abs (NAbs) in the recovered subjects discharged from the
hospital in full health. Serum samples from a total of 49 documented consecutive COVID-19 subjects were included in the study. Even though a majority of the recovered subjects had raised significant NAb titers, there is a substantial number of recovered patients
(10 out of 49) with no or low titers of NAbs against the virus. In these cohorts as well as in patients with high NAb titers, viral Ag binding Abs were detectable in EIA tests. Both NAb titers and EIA detectable Abs are increased in patients experiencing a
severe form of the disease, and in older patients the Ab titers were heightened. |
|
Detection of the SARS-CoV-2 humanized antibody
with paper-based ELISA |
Kasetsirikul, S, Umer, et al |
Analyst |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This work reports the development of a rapid, simple and inexpensive colorimetric paper-based assay for the detection
of the severe acute respiratory symptom coronavirus 2 (SARS-CoV-2) humanized antibody. |
|
Khanal, P, Devkota, et al |
Global Health |
Healthcare Response | Réponse des soins de santé |
The study aimed to identify factors associated with anxiety, depression and insomnia among health workers involved
in COVID-19 response in Nepal. This was a cross-sectional web-based survey conducted between April 26 and May 12, 2020. A total of 475 health workers participated in the study. Overall, 41.9% of health workers had symptoms of anxiety, 37.5% had depression
symptoms and 33.9% had symptoms of insomnia. Stigma faced by health workers was significantly associated with higher odds of experiencing symptoms of anxiety (AOR: 2.47; 95% CI: 1.62–3.76), depression (AOR: 2.05; 95% CI: 1.34–3.11) and insomnia (AOR: 2.37;
95% CI: 1.46–3.84). Nurses (AOR: 2.33; 95% CI: 1.21–4.47) were significantly more likely to experience anxiety symptoms than other health workers. |
|
|
Kim, LE, Asbury, et al |
Br J Educ Psychol |
Public Health response| Interventions de santé publique |
Twenty‐four teachers from English state schools were interviewed, representing mainstream primary and secondary schools
and a range of years of experience and seniority. Six themes were identified: uncertainty, finding a way, worry for the vulnerable, importance of relationships, teacher identity, and reflections. |
|
|
COVID-19 Pandemic Prediction using Time Series Forecasting Models |
Kumar, Naresh, Susan, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
we use day level information of COVID-19 spread for cumulative cases from whole world and 10 mostly affected countries;
US, Spain, Italy, France, Germany, Russia, Iran, United Kingdom, Turkey, and India. We utilize the temporal data of coronavirus spread from January 22, 2020 to May 20, 2020. We model the evolution of the COVID-19 outbreak, and perform prediction using ARIMA
and Prophet time series forecasting models. Effectiveness of the models are evaluated based on the mean absolute error, root mean square error, root relative squared error, and mean absolute percentage error. Our analysis can help in understanding the trends
of the disease outbreak, and provide epidemiological stage information of adopted countries. Our investigations show that ARIMA model is more effective for forecasting COVID-19 prevalence. The forecasting results have potential to assist governments to plan
policies to contain the spread of the virus. |
|
Li, J, Chen, et al |
BMC Infect Dis |
Clinical data| Données cliniques |
We report two cases of COVID-19 infection in renal transplant recipients with variable clinical presentations. The
first patient presented with mild respiratory symptoms and a stable clinical course. The second patient had more severe clinical characteristics and presented with severe pneumonia and multi-organ failure. Both patients received a combination therapy including
antiviral treatment and reduced immunosuppression therapy and finally recovered. |
|
|
Li, Jia, Rong, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to investigate whether the dynamic variation of cytokines was associated with the survival of patients admitted
to an intensive care unit (ICU). Among the 40 patients included, a significant positive correlation was found between multiple cytokines. Serum levels of IL-6, IL-10, and tumor necrosis factor alpha in non-survivors were consistently elevated compared to that
of the survivors. Kinetic variations of IL-6, IL-8, and IL-10 were associated with a fatal outcome in severe patients with COVID-19, independent of sex, age, absolute lymphocyte count, direct bilirubin, hypertension, chronic obstructive pulmonary disease,
and cancer. |
|
|
Li, Yize, Renner, et al |
bioRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
We compared the replication of SARS-CoV-2 and MERS-CoV in nasal epithelia-derived cells, a 120 relevant site of infection
in vivo, from four different donors. Robust activation of interferons or RNase L is not observed, while PKR activation is evident in iAT2 and iCM. In SARS-CoV-2 infected Calu-3 and A549ACE2 lung derived cell lines, activation of all pathways is observed, similar
to a mutant MERS-CoV lacking innate immune antagonists. Moreover, increased replication in RNASEL knockout A549ACE2 cells, implicates RNase L in restricting SARS-CoV-2. Finally, while SARS-CoV-2 is less adept at antagonizing these host defense pathways compared
to other coronaviruses, the innate immune response is still generally weak. |
|
|
Liu, JCJ, Tong, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
In this study, we sought to accomplish the following: (1) assess well-being during the pandemic; (2) replicate prior
findings linking exposure to COVID-19 news with psychological distress; and (3) examine whether subscription to an official WhatsApp channel can mitigate this risk. Depression scores were associated with increased time spent receiving COVID-19 updates, whereas
use of the official WhatsApp channel emerged as a protective factor (b=–0.07, t[863]=–2.04, P=.04). Similarly, increased anxiety scores were associated with increased exposure to both updates and rumors, but this risk was mitigated by trust in the government’s
WhatsApp messages (b=–0.05, t[863]=–2.13, P=.03). Finally, although stress symptoms increased with the amount of time spent receiving updates, these symptoms were not significantly related to WhatsApp use. Our findings suggest that messenger apps may be an
effective medium for disseminating pandemic-related information, allowing official agencies to reach a broad sector of the population rapidly. In turn, this use may promote public well-being amid an “infodemic.” |
|
|
Liu, Y, Xie, et al |
ESC Heart Fail |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A cohort of 43 patients with COVID‐19 who were in the intensive care unit (ICU) underwent bedside critical care echocardiography
(CCE) during their disease course. Pericardial effusion and increased ventricular mass in COVID‐19 might indicate a swollen heart. Both left and right heart dysfunction and a reduced cardiac index may lead to an increased risk of mortality. Clinicians should
pay special attention to cardiac haemodynamic disorders in critical patients with COVID‐19. |
|
|
Lu, Y, Li, et al |
J Clin Lab Anal |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study aims to compare the diagnostic efficacy between two different real‐time reverse transcription polymerase
chain reaction (RT‐PCR) test kits for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) nucleic acid detection and provide references for laboratories. The sensitivity, specificity, PPV, NPV, and kappa value of the Sansure PCR kit were 0.833, 1.000,
1.000, 0.971, and 0.894, respectively, and the sensitivity, specificity, PPV, NPV, and kappa value of the BioGerm PCR kit were 0.944, 1.000, 1.000, 0.990, and 0.966, respectively. For the three parallel tests, the coefficient of variation value of the BioGerm
PCR kit in all three samples was the smallest for both the ORF1ab and N gene. |
|
|
Luostarinen, T, Virta, et al |
Acta Neurochir (Wien) |
Healthcare Response | Réponse des soins de santé |
Our objective was to assess changes in ICU admissions and prognosis of traumatic brain injury (TBI) and aneurysmal
subarachnoid hemorrhage (SAH) during the Covid-19 pandemic admitted to the neurosurgical ICU in Helsinki from January to May of 2019 and the same months of 2020. Findings show in the area of Helsinki, Finland, there were no changes in the number of ICU admissions
or in prognosis of patients with TBI or SAH during the Covid-19 pandemic. |
|
|
Maghbooli, Z, Sahraian, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study investigates the association between serum 25-hydroxyvitamin D levels and its effect on adverse clinical
outcomes, and parameters of immune function and mortality due to a SARS-CoV-2 infection. After adjusting for confounding factors, there was a significant association between vitamin D sufficiency and reduction in clinical severity, inpatient mortality serum
levels of C-reactive protein (CRP) and an increase in lymphocyte percentage. Only 9.7% of patients older than 40 years who were vitamin D sufficient succumbed to the infection compared to 20% who had a circulating level of 25(OH)D< 30 ng/ml. The significant
reduction in serum CRP, an inflammatory marker, along with increased lymphocytes percentage suggest that vitamin D sufficiency also may help modulate the immune response possibly by reducing risk for cytokine storm in response to this viral infection. |
|
|
Martinelli, Axel, Akhmedov, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Seven in vitro studies of SARS, MERS, and SARS-CoV-2 were selected for comparative bioinformatic analysis through the
VirOmics Playground, a user-friendly visualisation and exploration platform we recently developed. Despite the heterogeneous nature of the data sets, several commonalities could be observed across studies and species. Differences, on the other hand, reflected
not only variations between species, but also other experimental variables, such as cell lines used for the experiments, infection protocols and potential discrepancies between transcriptome and proteome data. |
|
|
McCoy, J, Wambier, et al |
J Eur Acad Dermatol Venereol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We conducted a prospective longitudinal study of hospitalized COVID-19 males in order to assess if the androgen receptor
gene (AR) and related polyglutamine repeat (CAG) had a relationship with increase severity of Covid-19. The subjects were categorized into two cohorts: subjects with a CAG>=22 and subjects with a CAG<22. he proportion of subjects admitted to the ICU with
CAG<22 was significantly lower than the proportion of subjects with CAG>=22 (Fisher’s exact test p= 0.046791. Subjects with a CAG>=22 had a higher risk for ICU admissions compared to subjects with a CAG<22: OR 2.9143(95% CI: 1.0487-8.0985) and
Likelihood Ratio 1.705(95% CI: 0.985-2.951). |
|
|
Medrano, M, Cadenas-Sanchez, et al |
Pediatr Obes |
Public Health response| Interventions de santé publique |
The objective of this study was to examine the effects of the COVID‐19 confinement on lifestyle behaviours in Spanish
children, and to assess the influence of social vulnerabilities on changes in lifestyle behaviours by examining physical activity levels, screen time, sleep time, and diet. This study evidence the negative impact of the COVID‐19 confinement on physical activity
levels and sedentary behaviours of Spanish children. |
|
|
Miles, JA, Mejia Saldarriaga, et al |
Circ Cardiovasc Qual Outcomes |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We sought to compare characteristics and outcomes of in-hospital cardiac arrest (IHCA) during the COVID-19 pandemic
and prior to the pandemic in a NYC public hospital. There were 125 IHCAs during a 2.5-month period at our hospital during the peak of the COVID-19 pandemic compared to 117 IHCAs in all of 2019. Patients who experienced an IHCA during the COVID-19 pandemic
had overall worse survival compared to those who had an IHCA prior to the COVID-19 pandemic. |
|
|
Minocha, PK, Phoon, et al |
Clin Pediatr (Phila) |
Clinical data| Données cliniques |
We reviewed the clinical course and cardiac testing results in pediatric patients hospitalized with multisystem inflammatory
syndrome in children (MIS-C) at 2 large hospital systems in the New York City metropolitan area over a 3-month period. 73% of pediatric patients with MIS-C had evidence of abnormal cardiac testing on hospital admission in our study, all cardiac testing was
normal by outpatient hospital discharge follow-up. |
|
|
Miserocchi, E, Giuffrè, et al |
Ocul Immunol Inflamm |
Healthcare Response | Réponse des soins de santé |
We report on the management of juvenile patients at our pediatric referral center in Lobmbardy. During the lockdown
(phase 1), the weekly outpatient clinic was discontinued and telephone consultations were set up. A toll-free telephone number was instituted for emergencies. None of our children with JIA-associated uveitis was advised to stop the ongoing immunosuppressant
systemic therapy. We had no cases of COVID-19 infection and uveitis activity was under control in all but two out of 125 patients, which was comparable with the pre-COVID-19 situation. |
|
|
Mondi, A, Cimini, et al |
J Med Virol |
Clinical data| Données cliniques |
Here, we describe the experience of an Italian reference HIV/AIDS centre in one of the National referral hospitals
for COVID-19 with particular insights into immunologic response to SARS-CoV-2 infection. Our study did not find an increased risk and severity of COVID‐19 in PLWH. Adaptative cellular immune response to SARS‐CoV‐2 appeared to correlate to disease severity.
The mild clinical picture showed in advanced HIV patients, despite a significant T‐cell activation and inflammatory profile, suggests a potential role of HIV‐driven immunological dysregulation in avoiding immune‐pathogenetic processes. |
|
|
Monterrubio-Flores, Eric |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to describe the association between non-communicable diseases (NCDs) and Case Fatality
Rate (CFR) due to COVID-19 and identify related factors in Mexico. We analyzed 406,966 COVID-19 positive adults. The general CFR was 11.2%, while for men it was 13.7% and for women 8.4%. CFR is positively associated with age and number of NCDs (trend test
p<0.001). The combination of type 2 diabetes+chronic kidney failure has the highest CFR (44.0%). The number of comorbidities increase the CFR in younger adults, in which the relative risk from 0 to 3 or more NCDs was 30.2 in women and 11.8 in men. |
|
|
Montrone, M, Catino, et al |
Eur J Cancer |
Clinical data| Données cliniques |
Report of the case of a 69-year-old male patient affected by non-squamous stage IV anaplastic lymphoma kinase (ALK)-positive
non-small-cell lung cancer (NSCLC), treatment and outcome. |
|
|
Mrklas, K, Shalaby, et al |
JMIR Ment Health |
Healthcare Response | Réponse des soins de santé |
This study assessed the self-reported prevalence of stress, anxiety, depression, and obsessive-compulsive symptoms
in health care workers and other workers seeking support through Text4Hope, an evidence-based SMS text messaging service supporting the mental health of residents of Alberta, Canada, during the COVID-19 pandemic. Overall, 8267 surveys were submitted by 44,992
Text4Hope subscribers (19.39%). In the general sample, the 6-week prevalence rates for moderate or high stress, anxiety, and depression symptoms were 85.6%, 47.0%, and 44.0%, respectively. Self-reported symptoms of moderate or high stress, anxiety, and depression
were all statistically significantly higher in other workers than in health care workers (P<.001). Other workers reported higher obsessive-compulsive symptoms (worry about contamination and compulsive handwashing behavior) after the onset of the pandemic (P<.001),
while health care worker symptoms were statistically significantly higher before and during the COVID-19 pandemic (P<.001). |
|
|
Nardo, B, Lugaresi, et al |
Minerva Chir |
Healthcare Response | Réponse des soins de santé |
The aim of the study was to verify if the use of WhatsApp facilitates communication, improves health information, perception
of safe and security, reduce emotional stress during the COVID-19 emergency. Statistically significant differences were observed in the pre- vs post- COVID period regarding the number of surgical procedures (p = 0.004). In the post-COVID period, the satisfaction
questionnaire showed a good reliability (Cronbach's alpha 0.912) and a high percentage of satisfaction of patients and their families for the adopted communication tool, reassurance, privacy protection and reduction of emotional stress. |
|
|
MicroRNAs and long non-coding RNAs as potential candidates to target specific
motifs of SARS-CoV-2 |
Natarelli, Lucia, Parca, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
Here we describe our study indicating that SARS-CoV-2 genome contains motif sequences in the 5´UTR leader sequence
that can be selectively recognized by specific human non-coding RNAs (ncRNAs), such as micro and long non-coding RNAs (miRNAs and lncRNA). Notably, some of these ncRNAs have been already utilized as oligo-based drugs in pulmonary and virus-associated diseases.
We identified three selective motifs at the 5´UTR leader sequence of SARS-CoV-2 that allow viral recognition and binding of a specific group of miRNAs, some of them characterized by “GU” seed alignments. Additionally, one seed motif within miRNAs has been
found to be able to bind the 5’UTR leader sequence. Among miRNAs having thermodynamically stable binding site against leader sequence and that are able interacted with Spike transcript some are involved in pulmonary arterial hypertension and anti-viral response,
i.e. miR-204, miR-3661, and miR-1343. Moreover, several miRNA candidates have been already validated in vivo and specific oligo sequence are indeed available for their inhibition or overexpression. Four lncRNAs (H19, Hotair, Fendrr, and LINC05) directly interact
with spike transcript (mRNA) and viral genome. |
|
Nicoli, Francesco, Cabral-Piccin, et al |
bioRxiv |
Clinical data| Données cliniques |
Aging is associated with functional deficits in the naive T cell compartment, which compromise the generation of de
novo immune responses against previously unencountered antigens. The mechanisms that underlie this phenomenon have nonetheless remained unclear. We identified an age-related link between altered basal lipid metabolism and impaired antigen responsiveness in
the naive CD8+ T cell compartment. These abnormalities were associated with an enhanced susceptibility to activation-induced apoptosis and could be recapitulated in vitro by exposure to the homeostatic cytokine interleukin (IL)-7. Importantly, reversal of
the bioenergetic anomalies with lipid-altering drugs, such as rosiglitazone, almost completely restored the functional capabilities of naive CD8+ T cells. Interventions that favor lipid catabolism may therefore find utility as adjunctive therapies in the elderly
to promote vaccine-induced immunity against emerging pathogens, such as seasonal influenza viruses and SARS-CoV-2.Competing Interest StatementThe authors have declared no competing interest. |
|
|
Niedzwiedz, CL, Green, et al |
J Epidemiol Community Health |
Public Health response| Interventions de santé publique |
We examined trends in mental health and health behaviours in the UK before and during the initial phase of the COVID-19
lockdown and differences across population subgroups. Psychological distress increased 1 month into lockdown with the prevalence rising from 19.4% (95% CI 18.7% to 20.1%) in 2017-2019 to 30.6% (95% CI 29.1% to 32.3%) in April 2020 (RR=1.3, 95% CI 1.2 to 1.4).
Groups most adversely affected included women, young adults, people from an Asian background and those who were degree educated. Loneliness remained stable overall (RR=0.9, 95% CI 0.6 to 1.5). Smoking declined (RR=0.9, 95% CI=0.8,1.0) and the proportion of
people drinking four or more times per week increased (RR=1.4, 95% CI 1.3 to 1.5), as did binge drinking (RR=1.5, 95% CI 1.3 to 1.7). |
|
|
Park, J, Jeong, et al |
Yonsei Med J |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
We performed a quantitative proteomic analysis to investigate the expression of possible receptors for SARS-CoV-2 in
the intestinal mucosa of 23 patients with chronic colitis. ACE2 expression was low and remained unaltered in the gut of patients with ulcerative colitis (UC), Crohn's disease (CD), intestinal Behćet's disease (BD), and intestinal tuberculosis (TB), when compared
with that of healthy individuals. Additionally, the expression levels of some probable co-receptors, including dipeptidyl peptidase 4 (DPP4), aminopeptidase N (AMPN), and glutamyl aminopeptidase (AMPE), were unchanged in the affected UC, CD, intestinal BD,
and intestinal TB colon mucosa samples. In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2. |
|
|
Assessing the Interplay between travel patterns and SARS-CoV-2 outbreak in realistic urban
setting |
Patil, Rohan, Dave, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
In this study, we explore the impact of the creation of containment zones on travel patterns within the city. Further,
we use a dynamical network-based infectious disease model to understand the key drivers of disease spread at sub-kilometer scales demonstrated in the city of Ahmedabad, India, which has been classified as a SARS-CoV-2 hotspot. We find that in addition to the
contact network and population density, road connectivity patterns and ease of transit are strongly correlated with the rate of transmission of the disease. Given the limited access to real-time traffic data during lockdowns, we generate road connectivity
networks using open-source imageries and travel patterns from open-source surveys and government reports. Within the proposed framework, we then analyze the relative merits of social distancing, enforced lockdowns, and enhanced testing and quarantining mitigating
the disease spread. |
|
Proud, PamelaC, Tsitoura, et al |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
Authors show that prophylactic intra-nasal administration of the TLR2/6 agonist INNA-051 in a SARS-CoV-2 ferret infection
model effectively reduces levels of viral RNA in the nose and throat. The results of our study support clinical development of a therapy based on prophylactic TLR2/6 innate immune activation in the URT to reduce SARS-CoV-2 transmission and provide protection
against COVID-19. |
|
|
A modified age-structured SIR model for COVID-19 type viruses |
Ram, Vishaal, Schaposnik, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
We present a modified age-structured SIR model based on known patterns of social contact and distancing measures within
Washington, USA. We find that population age-distribution has a significant effect on disease spread and mortality rate, and contribute to the efficacy of age-specific contact and treatment measures. We consider the effect of relaxing restrictions across less
vulnerable age-brackets, comparing results across selected groups of varying population parameters. Moreover, we analyze the mitigating effects of vaccinations and examine the effectiveness of age-targeted distributions. Lastly, we explore how our model can
applied to other states to reflect social-distancing policy based on different parameters and metrics. |
|
Ratschen, E, Shoesmith, et al |
PLoS One |
Public Health response| Interventions de santé publique |
Authors aimed to investigate links between mental health and loneliness, companion animal ownership, the human-animal
bond, and human-animal interactions; and to explore animal owners' perceptions related to the role of their animals during lockdown. The human-animal bond is a construct that may be linked to mental health vulnerability in animal owners. |
|
|
Defining the Syrian hamster as a highly susceptible
preclinical model for SARS-CoV-2 infection |
Rosenke, Kyle, Meade-White, et al |
bioRxiv |
Animal model | Modèle animal |
Authors show that intranasal inoculation of SARS-CoV-2 into Syrian hamsters consistently caused moderate broncho-interstitial
pneumonia, with high viral lung loads and extensive virus shedding, but animals only displayed transient mild disease. The Syrian hamster is highly susceptible to SARS-CoV-2 making it a very suitable infection model for COVID-19 countermeasure development. |
|
Royer, O, Couture, et al |
Am J Respir Crit Care Med |
Clinical data| Données cliniques |
Authors present an example of the echographic evolution of one of their patients hospitalized in the ICU during the
outbreak. The clinical practice with ICU patients having SARS-CoV-2 pneumonia is to use the 12-zone lung ultrasound (LUS) score to quantify the severity of lung disease. |
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Safari, I, InanlooRahatloo, et al |
J Med Virol |
Coronavirology| Coronavirologie |
Authors analyzed 2790 SARS-CoV-2 genome sequences from 56 countries that were available on April 2, 2020 to assess
the evolution of the virus during this early phase of its expansion. The practical applications of these variations are discussed. |
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Predicting COVID-19 cases using Bidirectional LSTM on multivariate time series |
Said, Ahmed Ben, Erradi, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper presents a deep learning approach to forecast the cumulative number of COVID-19 cases using Bidirectional
Long Short-Term Memory (Bi-LSTM) network applied to multivariate time series. Using data of multiple countries in addition to lockdown measures improve accuracy of the forecast of daily cumulative COVID-19 cases. |
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A hybrid model based on mBA-ANFIS for COVID 19 confirmed cases prediction
and forecast |
Saif, Sohail, Das, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper a hybrid forecasting model has been proposed to determine the number of confirmed cases for upcoming
10 days based on the earlier confirmed cases found in India. Experimental results showthat the proposed model has achieved better performance in terms of Root Mean squared error (RMSE), Mean Absolute Percentage Error (MAPE), Mean absolute error (MAE) and
Normalized Root Mean Square Error (NRMSE). |
|
Saki, Mandana, Behzadifar, et al |
Research Square prepub |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
The purpose of this study was to investigate the effects of implementing social distancing policy, and the impact of
its lifting, with the resumption of social contacts and activities, as well as the effects of mandating face masks on the temporal trend of new COVID-19 cases in Iran. Methods: We employed the interrupted time series analysis (ITSA). Daily data were collected
from the Ministry of Health and Medical Education and the World Health Organization from 954 public hospitals and health center settings. Data were extracted 14 days before and after the implementation of each policy. Results: The slope of changes in new confirmed
cases following the implementation of the social distancing policy decreased by 118.79. With the resumption of social and economic activities in all provinces except for Tehran, initially the number of new daily confirmed cases was 3300, which was statistically
significant. The slope of changes due to the implementation of this policy was 47.89. A similar trend was detected with the resumption of social and economic activities in Tehran. With the implementation of the policy of mandatory use of masks, the slope of
changes showed a decrease of 25.84. |
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Schurink, Bernadette, Roos, et al |
The Lancet Microbe |
Clinical data| Données cliniques Immunology | Immunologie |
The aims of this study were to assess the duration of viral presence, identify the extent of inflammatory response,
and investigate the underlying cause of coagulopathy. |
|
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Sharfman, ZT, Loloi, et al |
J Am Acad Orthop Surg |
Healthcare Response | Réponse des soins de santé |
The aim of this report is to outline how our large academic orthopaedic surgery department adopted changes and alternative
practices in response to the most daunting challenge to public health in our region in over a century. |
|
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Vertical Transmission of SARS-CoV-2 from an Asymptomatic Pregnant Woman in India |
Singh, MV, Shrivastava, et al |
J Trop Pediatr |
Transmission Clinical data| Données cliniques |
We report a case of vertical transmission of SARS CoV-2 from an asymptomatic pregnant woman to her newborn baby who
had completely asymptomatic course in India. |
|
Smith, BM, Twohy, et al |
J Contextual Behav Sci |
Public Health response| Interventions de santé publique |
The current study explored the moderating role of psychological flexibility and related constructs on the relationships
between social isolation and mental health outcomes during the COVID-19 pandemic. Cross-sectional data from 278 participants, the majority residing in the United States, were collected during a 3-week period from mid-April to early May 2020 via online survey.
Psychological inflexibility, intolerance of uncertainty, and emotional suppression significantly moderated these relationships in a number of instances. Greater psychological flexibility and acceptance of difficult experiences appeared to act as a buffer against
the negative effects of increased social isolation, while amplifying the benefits of social connectedness. |
|
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Son, Juhee, Huang, et al |
bioRxiv |
Therapeutics| Thérapeutique Animal model | Modèle animal |
Two compounds, nitazoxanide and JIB-04 inhibited SARS-CoV-2 replication in Vero E6 cells with an EC50 of 4.90 μM and
0.69 μM, respectively, with specificity indices of greater than 150. Both inhibitors had in vitro antiviral activity in multiple cell types against some DNA and RNA viruses, including porcine transmissible gastroenteritis virus. In an in vivo porcine model
of coronavirus infection, administration of JIB-04 reduced virus infection and associated tissue pathology, which resulted in improved body weight gain and survival. These results highlight the potential utility of nitazoxanide and JIB-04 as antiviral agents
against SARS-CoV-2 and other viral pathogens. |
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Spalluto, M, Bevilacqua, et al |
Minerva Chir |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to report how this situation forces surgeons to consider a nonoperative management as an alternative
choice. This is a retrospective monocentric study and we collected data from 60 patients, splitted in two groups: info from Group A, 28 patients (March 11th to April 11th 2020) were compared with info from Group B, 32 patients (March 11th to April 11th 2019).
The two groups had a considerably different number of cases that were treated with an operative management: 18 cases (64,7%) in Group A vs 28 cases (87,5%) in Group B. Otherwise, non-perative approach occurred in 10 cases (35,7%) in group A and only in 4 patients
(12,5%) in group B. These data suggest that the drastic reduction of means narrows the range of therapeutic choices. |
|
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The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in
Patients with COVID-19 |
Sun, HB, Zhang, et al |
PLoS One |
Clinical data| Données cliniques Immunology | Immunologie |
To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory
cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients
with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease. |
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Using Smartphones and Wearable Devices to Monitor Behavioral Changes During COVID-19 |
Sun, S, Folarin, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
We aim to explore the utility of the recently developed open-source mobile health platform Remote Assessment of Disease
and Relapse (RADAR)-base as a toolbox to rapidly test the effect and response to NPIs intended to limit the spread of COVID-19. We analyzed data extracted from smartphone and wearable devices, and managed by the RADAR-base from 1062 participants recruited
in Italy, Spain, Denmark, the United Kingdom, and the Netherlands. We were able to quantify expected changes in time spent at home, distance travelled, and the number of nearby Bluetooth-enabled devices between prelockdown and during lockdown periods (P<.001
for all five countries). We saw reduced sociality as measured through mobility features and increased virtual sociality through phone use. People were more active on their phones, spending more time using social media apps, particularly around major news events.
Furthermore, participants had a lower heart rate, went to bed later, and slept more . We also found that young people had longer homestay than older people during the lockdown and fewer daily steps. Although there was no significant difference between the
high and low BMI groups in time spent at home, the low BMI group walked more. |
|
Sutin, AR, Stephan, et al |
Obesity (Silver Spring) |
Public Health response| Interventions de santé publique |
This study aimed to examine the trajectory of psychological distress and well-being across the coronavirus pandemic
by body mass index (BMI) category and weight discrimination. Prior to the pandemic, reporting weight discrimination or being in the underweight or obesity 2-3 category was associated with more distress and lower well-being. Weight discrimination, not BMI,
was associated with a 2-fold increased risk of incident depression from before to during the pandemic. Weight discrimination was associated with declines in purpose in life and life satisfaction across the pandemic. BMI categories were unrelated to changes
in distress/well-being across the pandemic. |
|
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Taiwo, IdowuA, Adeleye, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Whole genome sequence data of SARS-CoV-2 isolated from Nigerian COVID-19 cases were retrieved by downloading from GISAID
database. Nigerian SARS-CoV-2 had 99.9% genomic similarity with four large conserved genomic regions. A total of 66 SNPs were identified out of which 31 were informative. Nigeria SARS-CoV-2 revealed 3 major clades namely Oyo, Ekiti and Osun on a maximum likelihood
phylogenetic tree. Nigerian SARS-CoV-2 reveals high mutation rate together with preponderance of L lineage and D614G mutants. Implication of these mutations for SARS-CoV-2 virulence and the need for more aggressive testing and treatment of COVID-19 in Nigeria
is discussed. |
|
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Tao, W, Wang, et al |
Protein Cell |
Clinical data| Données cliniques |
Here, we investigated whether the intestine might be a “reservoir” of SARS-CoV-2 and one of the potential causes of
re-detectable positive (RP). Between January 21 and March 8, 2020, a total of 173 patients who had COVID-19 were discharged from hospitals in Hefei, China. Our results strongly suggest that negative fecal detection (at least rectal swab detection) should be
included as one of the criteria for hospital discharge of patients recovering from COVID-19. |
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Wajnberg, Ania, Mansour, et al |
The Lancet Microbe |
Epidemiology| Épidémiologie Immunology | Immunologie |
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The proportion
of infected individuals who seroconvert is still an open question. In addition, it has been shown in some individuals that viral genome can be detected up to 3 months after symptom resolution. We investigated both seroconversion and PCR positivity in a large
cohort of convalescent serum donors in the New York City (NY, USA) region. |
|
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Xu, R, Cui, et al |
J Med Virol |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This retrospective study screened useful predictors of critical cases among COVID-19 patients and developed a simple-to-use
nomogram for clinical utility. The variables of age, comorbid diseases, neutrophil-to-lymphocyte ratio, D-Dimer, C-reactive protein, and platelet count were estimated to be independent predictors of progression to critical, which were incorporated to establish
a model of the nomogram. It demonstrated good discrimination (with a C-index of 0.923) and calibration. Good discrimination (C-index, 0.882 and 0.906) and calibration were also noted on applying the nomogram in two validation cohorts. The clinical relevance
of the nomogram was justified by the decision curve and clinical impact curve analysis. |
|
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Xue, J, Chen, et al |
PLoS One |
Public Health response| Interventions de santé publique |
The study aims to understand Twitter users' discourse and psychological reactions to COVID-19. We use machine learning
techniques to analyze about 1.9 million Tweets (written in English) related to coronavirus collected from January 23 to March 7, 2020. A total of salient 11 topics are identified and then categorized into ten themes, including "updates about confirmed cases,"
"COVID-19 related death," "cases outside China (worldwide)," "COVID-19 outbreak in South Korea," "early signs of the outbreak in New York," "Diamond Princess cruise," "economic impact," "Preventive measures," "authorities," and "supply chain." Results do not
reveal treatments and symptoms related messages as prevalent topics on Twitter. Sentiment analysis shows that fear for the unknown nature of the coronavirus is dominant in all topics. Implications and limitations of the study are also discussed. |
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Ultrafast Screening of COVID-19 by Machine Learning Analysis of Exhaled
NO |
Yang, Li, Zhou, et al |
Research Square prepub |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study reports a rapid and low-cost method for preliminary screening COVID-19 suspects from healthy people. Established
a machine learning (ML) model based on the fractional exhaled nitric oxide (FeNO) concentration, age, sex and body size of 34 COVID-19 patients and 70 healthy subjects. Then, the model was applied to 45 independent subjects, including 12 mild and asymptomatic
COVID-19 patients, 10 patients with other diseases, and 23 healthy subjects. The patients with diseases affecting the FeNO including COVID-19, asthma, hypertension and etc were screened out as suspects with the rate of 94.1%. This noninvasive and comfortable
detection procedure takes in two minutes and costs less than a dollar, which simultaneously improves the detection efficiency and reduces expenses. |
|
Yang, X, Dai, et al |
J Cell Mol Med |
Clinical data| Données cliniques Immunology | Immunologie |
This study collected blood samples from 18 healthy donors (HDs) and 38 COVID-19 patients to analyse changes in the
adaptive immune cell populations and their phenotypes. Observed that the lymphocyte percentage moderately decreased, CD4 and CD8 T cell percentage among lymphocytes were similar, and B cell percentage was increased in COVID-19 patients in comparison to that
in HDs. T cells, especially CD8 T cells, showed an enhanced expression of late activation marker CD25 and exhaustion marker PD-1. Importantly, SARS-CoV-2 infection increased the percentage of T follicular helper- and germinal centre B-like cells in the blood.
The parameters in COVID-19 patients remained unchanged across various age groups. |
|
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A high-affinity RBD-targeting nanobody improves fusion
partner’s potency against SARS-CoV-2 |
Yao, Hebang, Cai, et al |
bioRxiv |
Coronavirology| Coronavirologie |
This study identified and characterized a high-affinity synthetic nanobody (sybody, SR31) as a fusion partner to improve
the potency of receptor-binding motif (RBM)-antibodies. Crystallographic studies reveal that SR31 binds to RBD at a conserved and ‘greasy’ site distal to RBM. Although SR31 distorts RBD at the interface, it does not perturb the RBM conformation, hence displaying
no neutralizing activities itself. However, fusing SR31 to two modestly neutralizing sybodies dramatically increases their affinity for RBD and neutralization activity against SARS-CoV-2 pseudovirus. |
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Increased Serum Levels of Hepcidin and Ferritin Are Associated with Severity of COVID-19 |
Zhou, C, Chen, et al |
Med Sci Monit |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective study assessed the diagnostic utility of iron homeostasis determinations for prediction of severity
of COVID-19. Patients diagnosed with severe COVID-19 had higher hepcidin and serum ferritin levels than in other groups (p<0.001). A combination test of hepcidin and serum ferritin provided the best specificity and sensitivity in the prognosis of COVID-19
severity. Logistic regression analysis showed hepcidin and serum ferritin independently contributed to the severity of COVID-19. Hepcidin and serum ferritin tandem testing predicted COVID-19 severity with 94.6% specificity, while hepcidin and serum ferritin
parallel testing had a sensitivity of 95.7%. |
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Google Trends reveal increases in internet searches for insomnia during the COVID-19 global
pandemic |
Zitting, KM, Lammers-van der Holst, et al |
J Clin Sleep Med |
Public Health response| Interventions de santé publique |
This study estimated the effect of COVID-19 on insomnia levels worldwide and in the United States during the acute
phase of the pandemic by analyzing search query data recorded between January 2004 and May 2020 from Google Trend and Google Keyword Planner for the search term insomnia. The COVID-19 pandemic increased search queries for insomnia both worldwide and in the
United States, with the number in the United States increasing by 58% during the first five months of 2020 compared to same months from the previous three years. There is a robust diurnal pattern in insomnia search queries in the United States, with the number
of queries peaking around 3 AM and the overall pattern remaining stable during the pandemic. |
|
Zurita, MF, Iglesias Arreaga, et al |
Am J Case Rep |
Clinical data| Données cliniques |
This case series describes 5 patients with SARS-CoV-2 infection and COVID-19 in Ecuador who had been treated with hydroxychloroquine
for systemic lupus erythematosus (SLE) prior to their COVID-19 illness. All 5 patients with SLE were taking hydroxychloroquine when they presented with SARS-CoV-2 infection. This case series provides support for a lack of prevention of COVID-19 by hydroxychloroquine. |
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Delaying surgery for patients with a previous SARS-CoV-2 infection |
|
Br J Surg |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
Operating on patients with an active perioperative SARS‐CoV‐2 infection is known to carry a very high pulmonary complication
and mortality rate. The COVIDSurg‐Cancer study was a prospective cohort study of patients undergoing curative elective cancer surgery during the COVID‐19 pandemic up to 24 May 2020. We performed a pre‐planned subgroup analysis of patients undergoing surgery
with previous SARS‐CoV‐2 positive swab that were not suspected to have active COVID‐19 at the time of surgery. Of 122 patients with a previous positive SARS‐CoV‐2 swab, 22·1% (n = 27) were operated on within 2‐weeks of diagnosis, 49·2% (n = 60) between 2
and 4 weeks, and 28·7% (n = 35) after 4 weeks. In the propensity score matched model, previous SARS‐CoV‐2 infection was associated with increased odds of pulmonary complications compared to no infection (10·7% [12/122] versus 3·6% [16/448], adjusted odds ratio
3·84, 95% confidence interval 1·51‐9·74, p = 0·004). When split by time from swab to surgery, both pulmonary complications and mortality were lowest at least 4 weeks after notification of a positive swab test. However, 71·3% (87/122) of patients had surgery
within 4 weeks of SARS‐CoV‐2 infection in this series. |
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Al-Halabi, M, Salami, et al |
Eur Arch Paediatr Dent |
Review Literature| Revue de littérature |
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Alquisiras-Burgos, I, Peralta-Arrieta, et al |
Mol Neurobiol |
Review Literature| Revue de littérature |
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Bull, S, Jamrozik, et al |
J Med Ethics |
Review Literature| Revue de littérature |
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Cornejo-Pareja, I, Gómez-Pérez, et al |
Eur Eat Disord Rev |
Review Literature| Revue de littérature |
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Freedman, DO, Wilder-Smith, et al |
J Travel Med |
Review Literature| Revue de littérature |
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Otorhinolaryngological manifestations of COVID-19-A systematic review |
Govindarajalu, Priyadarshini, Shah, et al |
Research Square prepub |
Review Literature| Revue de littérature |
SR: PubMed was searched with filters as ‘2020’ year of study on 7/08/2020 at 11.30 Am. As a practising otorhinolaryngologist,
a good insight into the otorhinolaryngological manifestations of COVID-19 is essential to differentiate between the prodromal symptoms of COVID-19 and non-COVID viral upper respiratory tract infection. |
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Iodice, Francesco, Cassano, et al |
Research Square prepub |
Review Literature| Revue de littérature |
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Jack, L, J |
Prev Chronic Dis |
Review Literature| Revue de littérature |
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Malik, P, Patel, et al |
J Med Virol |
Review Literature| Revue de littérature |
SR-MA: PubMed, Web of Science, Scopus and medRciv were searched from December 1, 2019, to August 15, 2020. Our study
suggests a significant association between obesity and COVID-19 severity and poor outcomes.
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COVID-19: Current understanding of its Pathophysiology, Clinical presentation
and Treatment |
Parasher, A |
Postgrad Med J |
Review Literature| Revue de littérature |
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Rios, P, Radhakrishnan, et al |
Syst Rev |
Review Literature| Revue de littérature |
Rapid Review: EMBASE, MEDLINE, Cochrane library, pre-print servers, clinical trial registries, and relevant grey literature
sources were searched until July 31, 2020. Current evidence suggests robust surveillance and monitoring along with support for IPAC initiatives are key to preventing the spread of COVID-19 in LTCF.
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Implications of human activities for (re)emerging infectious diseases, including
COVID-19 |
Sabin, NS, Calliope, et al |
J Physiol Anthropol |
Review Literature| Revue de littérature |
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Coronavirus Disease 2019 (COVID-19) and Nutritional Status: The Missing Link? |
Silverio, R, Gonçalves, et al |
Adv Nutr |
Review Literature| Revue de littérature |
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Why COVID-19 is less frequent and severe in children: a narrative review |
Sinaei, R, Pezeshki, et al |
World J Pediatr |
Review Literature| Revue de littérature |
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Song, Danlei, Huang, et al |
Research Square prepub |
Review Literature| Revue de littérature |
SR-MA: selected eligible studies with strict inclusion and exclusion criteria after systematically searching 7 databases
up to May 30, 2020. : Our research showed that adding TCM wouldn’ t damage the COVID-19 patients’ liver function. On the contrary, it may reduce the risk. |
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Viner, RM, Mytton, et al |
JAMA Pediatr |
Review Literature| Revue de littérature |
SR-MA: PubMed and medRxiv were searched from database inception to July 28, 2020. In this meta-analysis, there is preliminary
evidence that children and adolescents have lower susceptibility to SARS-CoV-2, with an odds ratio of 0.56 for being an infected contact compared with adults. There is weak evidence that children and adolescents play a lesser role than adults in transmission
of SARS-CoV-2 at a population level. |
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The therapeutic effects of traditional chinese medicine on COVID-19: a narrative
review |
Wang, C, Sun, et al |
Int J Clin Pharm |
Review Literature| Revue de littérature |
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Yao, Y, Wang, et al |
Clin Exp Allergy |
Review Literature| Revue de littérature |
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Zekarias, A, Watson, et al |
Drug Saf |
Review Literature| Revue de littérature |
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Agarwal, A, Chaurasia, et al |
Pathog Glob Health |
Commentary/Editorial| Commentaire/Éditorial |
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Orchestrating Collaborative Research and Clinical Trials during COVID-19 Pandemic
- A New Normal |
Agrawal, R |
Ocul Immunol Inflamm |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7492057; Nanoceria as a possible agent for the management of COVID-19 |
Allawadhi, P, Khurana, et al |
Nano Today |
Commentary/Editorial| Commentaire/Éditorial |
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Arora, P, Sardana, et al |
J Cosmet Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Ayele, BA, Zenebe, et al |
eNeurologicalSci |
Commentary/Editorial| Commentaire/Éditorial |
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Baecher-Lind, L, Fleming, et al |
Obstet Gynecol |
Commentary/Editorial| Commentaire/Éditorial |
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Barbaro, RyanP, MacLaren, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Personal protective equipment use in laparoscopy during COVID-19 |
Bhattacharya, K |
J Minim Access Surg |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7362806; Coronavirus infection in cancer patients, last update |
Borregón Rivilla, M, Martínez Barroso, et al |
Med Clin (Barc) |
Commentary/Editorial| Commentaire/Éditorial |
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Braga, A, Elias, et al |
Am J Obstet Gynecol |
Commentary/Editorial| Commentaire/Éditorial |
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Bury, TJ, Stokes, et al |
Phys Ther |
Commentary/Editorial| Commentaire/Éditorial |
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Campanella, S, Arikan, et al |
Clin EEG Neurosci |
Commentary/Editorial| Commentaire/Éditorial |
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Caporali, C, Pisoni, et al |
Child Care Health Dev |
Commentary/Editorial| Commentaire/Éditorial |
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Caselli, D, Chironna, et al |
Br J Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Chiang, CY, Islam, et al |
Eur Respir J |
Commentary/Editorial| Commentaire/Éditorial |
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Defining Covid 19 containment zones using K-means dynamically |
Chinchorkar, Satish |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7421297; Apps for COVID-19 contact-tracing: Too many questions and few answers |
Cioffi, A, Lugi, et al |
Ethics Med Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 and acute perforated diverticulitis: management and surgical timing |
Costanzi, A, Monteleone, et al |
Minerva Chir |
Commentary/Editorial| Commentaire/Éditorial |
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Emotion Regulation and Bipolar Disorder: Strategies during the COVID-19 Pandemic |
de Siqueira Rotenberg, L, Cohab Khafif, et al |
Bipolar Disord |
Commentary/Editorial| Commentaire/Éditorial |
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Delgado, A, Santos Lira, et al |
Obstet Gynecol |
Commentary/Editorial| Commentaire/Éditorial |
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The implications of vitamin D deficiency on COVID-19 for at-risk populations |
DeLuccia, R, Clegg, et al |
Nutr Rev |
Commentary/Editorial| Commentaire/Éditorial |
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Response to: SARS-CoV-2 associated Guillain-Barré syndrome in 62 patients |
Doneddu, PE, De Sanctis, et al |
Eur J Neurol |
Commentary/Editorial| Commentaire/Éditorial |
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Ehrhardt, N, Hirsch, et al |
Diabetes care |
Commentary/Editorial| Commentaire/Éditorial |
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It's Time to Put Children and Young People First During the Global COVID-19
Pandemic |
Faust, SN, Munro, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Beware COVID-19 on VQ scans (Ventilation/Perfusion Scintigraphy) |
Fielding, PA, Morley, et al |
Qjm |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2 associated Guillain-Barre syndrome in 62 patients |
Finsterer, J, Scorza, et al |
Eur J Neurol |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2 antibody seroprevalence in patients receiving dialysis in the USA |
Flower, Barnaby, Atchison, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Goldfarb, EV |
Nat Rev Neurosci |
Commentary/Editorial| Commentaire/Éditorial |
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Goldstein, JL |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
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Are T cells helpful for COVID-19: the relationship between response and risk |
Griffin, DE |
J Clin Invest |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Diagnosis of common conditions in general practice halved during lockdown, study
finds |
Griffin, S |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Learn from other countries about easing lockdown, researchers urge |
Griffin, S |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7366077; Child Care in the Time of Coronavirus Disease-19: A Period of Challenge
and Opportunity |
Hashikawa, AN, Sells, et al |
J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Preparing for COVID-19 Vaccine Safety Surveillance: A United States Perspective |
Haynes, K |
Pharmacoepidemiol Drug Saf |
Commentary/Editorial| Commentaire/Éditorial |
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Hermesch, AC, Horve, et al |
Obstet Gynecol |
Commentary/Editorial| Commentaire/Éditorial |
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COVID 19: Prioritise Autonomy, Beneficence and Conversations Before Score-based Triage |
Ho, EP, Neo, et al |
Age Ageing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
The forgotten people with thalassemia in the time of COVID-19: South Asian perspective |
Hossain, MS, Raheem, et al |
Orphanet J Rare Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
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PharmGKB tutorial for pharmacogenomics of drugs potentially used in the context of COVID-19 |
Huddart, R, Whirl-Carrillo, et al |
Clin Pharmacol Ther |
Commentary/Editorial| Commentaire/Éditorial |
|
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Hughes, TG |
Surg Clin North Am |
Commentary/Editorial| Commentaire/Éditorial |
|
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Recommendations on COVID-19 triage: international comparison and ethical analysis |
Jöbges, S, Vinay, et al |
Bioethics |
Commentary/Editorial| Commentaire/Éditorial |
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Kawachi, I |
Int J Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
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[The urgency of deep institutional reforms in global health in the face of Covid-19
pandemic] |
Kazatchkine, M |
Med Sci (Paris) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Coronaviruses in farm animals: Epidemiology and public health implications |
Khamassi Khbou, M, Daaloul Jedidi, et al |
Vet Med Sci |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kim, E, Ko, et al |
J Public Health Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kmietowicz, Z |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Kreps, SE, Kriner, et al |
Sci Adv |
Commentary/Editorial| Commentaire/Éditorial |
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Lamas, NJ, Costa, et al |
Cancer Cytopathol |
Commentary/Editorial| Commentaire/Éditorial |
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Lankes, HA, Makhlouf, et al |
Am J Clin Pathol |
Commentary/Editorial| Commentaire/Éditorial |
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Did the COVID-19 lockdown really have no impact on young children's sleep? |
Lecuelle, F, Leslie, et al |
J Clin Sleep Med |
Commentary/Editorial| Commentaire/Éditorial |
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Leichlé, T, Nicu, et al |
ACS Sens |
Commentary/Editorial| Commentaire/Éditorial |
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Upper respiratory samples pooling for screening SARS-CoV-2 infection: ready for the
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Lippi, G |
Clin Chem Lab Med |
Commentary/Editorial| Commentaire/Éditorial |
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Liu, JJ |
Cancer Causes Control |
Commentary/Editorial| Commentaire/Éditorial |
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Lo, YL |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
|
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Lyons, AB, Hamzavi, et al |
Photodermatol Photoimmunol Photomed |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-vaccine results are on the way - and scientists' concerns are growing |
Mallapaty, S, Ledford, et al |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
|
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Marinaccio, Alessandro, Guerra, et al |
The Lancet Global Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Martin, RF |
Surg Clin North Am |
Commentary/Editorial| Commentaire/Éditorial |
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Corticosteroids, COVID-19 pneumonia and acute respiratory distress syndrome |
Matthay, MA, Wick, et al |
J Clin Invest |
Commentary/Editorial| Commentaire/Éditorial |
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McDougall, RJ, Gillam, et al |
J Med Ethics |
Commentary/Editorial| Commentaire/Éditorial |
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Middleton, J, Adongo, et al |
Int J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Challenges to peer support in low- and middle-income countries during COVID-19 |
Mpango, R, Kalha, et al |
Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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Mykhalovskiy, E, Kazatchkine, et al |
Can J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Quantification of SARS-CoV-2 neutralizing antibody by a pseudotyped virus-based
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Nie, J, Li, et al |
Nat Protoc |
Commentary/Editorial| Commentaire/Éditorial |
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Norman, WV |
Am J Obstet Gynecol |
Commentary/Editorial| Commentaire/Éditorial |
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Shedding light on the myths of ultraviolet radiation in the Covid-19 pandemic |
O'Connor, C, Courtney, et al |
Clin Exp Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: App to track close contacts is launched in England and Wales |
O'Dowd, A |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
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Further information on possible animal sources for human COVID-19 |
Opriessnig, T, Huang, et al |
Xenotransplantation |
Commentary/Editorial| Commentaire/Éditorial |
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Owens, IT |
Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Pablos, JL, Galindo, et al |
Ann Rheum Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Ann Intern Med |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans e.g.
WHO publication list and activities by collaborators. Members of the Emerging Sciences group develop 1 -2 point summaries of each publication. Please email Lisa Waddell for additional information:
Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability
to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely to influence future results.
Epidemiology:
the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro, attack rates, case number doubling time, case fatality
rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host
to an uninfected host via direct or indirect routes.
Clinical data
of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well as clinical profiles of patients; presenting symptoms, symptoms over
course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and
interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed, number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic
analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics:
Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research:
Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities:
These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response:
This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment preparation/ stock piling supplies; Education
and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature:
All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial:
For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, e.g.
la liste des publications de l'OMS,
et à des activités des collaborateurs. Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction :
La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats. Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro),
les taux d'attaque, le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que les profils
cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance
de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé. Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes
guéries. *
Coronavirologie : Toutes les recherches relatives
au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes :
Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes, etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la
vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Modèle animal:
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial :
Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des
commentaires.
journaux
Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives