Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19,
2020-09-23
Good afternoon,
There are 1250 citations in today’s scan. 657 were considered primary research or review literature.
Highlights today include:
CANADA
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Yau et al investigate an outbreak in an Urban hemodialysis Unit. They describe the course of a COVID-19 outbreak in the unit and the
infection control measures taken for mitigation. By implementing universal screening by RT-PCR and universal droplet and contact precautions they were able to prevent further transmissions in the unit.
·
Mohammed et al., examine how mask usage by Canadians changed in the months since the onset of the pandemic in Canada. Despite the policy reversal on masks by Canadian
public health officials, the survey data collected from the COVID-19 Monitor indicate that Canadians were responsive to changing guidance, self-reported usage rises from 5 percent in late March to 63 percent by early June. Notably, the inflection point appears
to take place in early April and corresponds with the issuance of revised guidance on masks by PHAC.
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Pacheco et al., highlight that marginalized workers in Canada (e.g., women, migrants, people facing financial hardships) reported lower
job security, and having temporarily lost one’s job was negatively associated with job security during the pandemic.
IPAC
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Heilingloh et al.,
determined the susceptibility of SARS-CoV-2 to irradiation with ultraviolet light. The UVC dose required for complete inactivation was 1,048 mJ/cm2. UVA exposure demonstrated only a weak effect
on virus inactivation over 15 minutes. Hence, inactivation of SARS-CoV-2 by UVC irradiation constitutes a reliable method for disinfection purposes in health care facilities and for preparing SARS-CoV-2 material
for research purpose.
TRANSMISSION
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Kim et al. suggest that remote airborne transmission of SARS-CoV-2 from hospitalized COVID-19 patients is uncommon when aerosol-generating
procedures have not been performed.
EPIDEMIOLOGY
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Jeong et al suggest that true asymptomatic SARS-CoV-2 infection may be rare. In their case series of 40 hospitalized laboratory confirmed SARS-CoV-2 cases prevalence
of asymptomatic infection was 5%, lower than previously reported, and that of presymptomatic infection was 13%. They suggest that cough, fever, myalgia, rhinorrhea or nasal congestion, and diarrhea are adequate screening criteria for covering all symptoms
of SARS-CoV-2 infection.
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Akinbani et al:
estimated seroprevalence of SARS-CoV-2 among healthcare, first response, and public safety personnel by conducting antibody testing. , Of 16,403 participants, 6.9% had SARS-CoV-2 antibodies. In adjusted analyses, seropositivity was associated with exposure
to SARS-CoV-2–positive household members and working within 15 km of Detroit. Nurse assistants and nurses had higher likelihood of seropositivity than physicians. Working in a hospital emergency department increased the likelihood of seropositivity. Consistently
using N95 respirators and surgical facemasks decreased the likelihood of seropositivity.
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Anand et al:
described the clinic-demographic profile and viral load in neonates born to COVID 19 positive mothers. Viral load in neonates was comparable with the Ct reported from adults; however, neonates had milder clinical manifestations. All 7 neonates who tested
positive for COVID 19 were subsequently discharged. Six of the 7 neonates were asymptomatic and 1 neonate needed respiratory support (indication being prematurity) which resolved after 48 h. Viral loads of mothers with COVID 19 positive neonates compared with
mothers with COVID 19 negative neonates for E and RdRp gene were also statistically non-significant. The majority (93%) of neonates tested later than 48 h (roomed in with mother and breastfed) tested negative.
·
Fond et al.,
suggests that schizophrenia (SCZ) patients are not overrepresented among COVID-19 hospitalized patients, but SCZ is associated with excess COVID-19 mortality (adjusted odds ratio 4.36 95% CI: 1.09–17.44]; P = 0.038, adjusted for age, sex, smoking status,
obesity and comorbidity), confirming the existence of health disparities described in other somatic diseases.
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Ehrhardt et al
investigated data from SARS-CoV-2 infected 0-19 year olds, who attended schools/childcare facilities, to assess their role in SARS-CoV-2 transmission after these establishments reopened in Germany. Six of the 137 cases were found to have infected a total
of 11 additional pupils. The remaining cases with information on school attendance were caused by sources outside of school and childcare facilities. Their findings suggest that child-to-child transmission in schools and childcare facilities is uncommon and
not the primary cause of SARS-CoV-2 infection in children. Based on their estimation there could be one secondary case per roughly 25 infectious school days.
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Pierce et al.
compared cytokine, humoral, and cellular immune responses in pediatric (n=65) and adult (n=60) patients with COVID-19 at a metropolitan hospital system in New York City. The pediatric patients had a shorter length of stay, decreased mechanical ventilation
requirements, and lower mortality compared to adults. The serum concentrations of IL-17A and IFN-γ, but not TNF-α or IL-6, were inversely related to age. Adults mounted a more robust T cell response to the viral spike protein than pediatric patients. Moreover,
serum neutralizing antibody titers and antibody-dependent cellular phagocytosis was higher in adults compared to pediatric COVID-19 patients. The neutralizing antibody titer correlated positively with age and negatively with IL-17A and IFN-γ serum concentrations.
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Liu, et al.
enrolled 140 medical workers with COVID‐19 in Wuhan. Epidemiological, demographic, clinical, laboratory, radiological, treatment and clinical outcome data were collected, and predictors of the duration of viral shedding were explored through multivariable
linear regression analysis. Glucocorticoid treatment and lymphocytes less than 1.1 × 109/L are associated with prolonged viral shedding. Early admission and rIFN‐α treatment help shorten the duration of viral shedding.
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Massey, et al.
determined the prevalence and type of a wide variety of respiratory pathogens in 12,075 United States subjects tested for SARS-CoV-2 infection in March and April 2020. Infections with other respiratory pathogens were present in both SARS-CoV-2 + and
SARS-CoV-2- subjects. Among the co-pathogens present in both subject groups were K. pneumoniae and M. catarrhalis. Advanced age and nursing home status were associated with higher SARS-CoV-2 + and co-infection rates.
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Gao et al.,
(preprint) describe the use of human activities measured by venable distances and activity density as a good early indicator for spread of COVID-19 during the early in the pandemic. They show significant time lag relationships between changes in activity
and the reproduction number, indicating the possible utility of human activitiy measurements in predicting COVID-19 transmission in the community
CLINICAL DATA
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Chao et al report a female infant born to a woman who had been diagnosed with COVID-19 at 26+6 weeks of pregnancy. Throat swabs obtained from the infant on day 2, 3 and 8
after birth were all negative for SARS-Cov-2. SARS-Cov-2 IgM in the neonatal serum were negative on samples from day 2 and 8. Elevated IgG levels were observed, suggesting that antibodies may have come from the mother. According to this case report, no intrauterine
vertical transmission was found.
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Corcorran et al
describe a SARS-CoV-2 outbreak within an inpatient geriatric psychiatry unit at the University of Washington Medical Center. Asymptomatic infection was common in this cohort of hospitalized elderly individuals (30%) despite similar duration of SARS-CoV-2
RT-PCR positivity and cycle threshold values among symptomatic and asymptomatic patients.
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Ludzik, et al.
report new dermatologic findings have been described in association with COVID-19 that can potentially be a distinguishing feature of infection. One such feature resembles chilblains and this case report represents a presentation of this feature with
a 48-year-old female with violaceous lesions with surrounding pink erythema on her toes who tested negative for COVID-19.
SURVEILLANCE
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Ferrari et al.,
Retrospectively examine routine blood tests for AST and LDH levels from 30000 patients admitted since September 2018. The results indicate that AST and LDH levels are highly sensitive to the presence of COVID-19 and may be a good surveillance indicator
of the presence of COVID-19 circulation. They also suggest in a
separate paper on the same data that use of AST and LDH along side a false-negative PCR results to indicate COVID-19 would reduce the false negative rate by 4-fold.
THERAPEUTICS
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Hueso et al report a case series of 17 consecutive patients with profound B-cell lymphopenia
and prolonged COVID-19 symptoms, negative IgG-IgM SARS-CoV-2 serology and a positive RNAemia measured by digital PCR who were treated with four units of COVID-19 convalescent plasma. They found that in these COVID-19 patients unable to mount a specific humoral
response to SARS-CoV-2, convalescent plasma with anti-SARS-CoV-2 antibodies no adverse events were reported and patients showed improvement of clinical symptoms and virus-specific T cell responses.
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Kumar et al.
This study aimed to study the binding potential of various phytochemicals present in multiple natural plant extract as a secondary metabolite to non-structural protein 15 (Nsp15) protein, a drug target known to play a crucial
role in virulence of coronavirus. The study successfully demonstrated the binding of phytochemicals such as sarsasapogenin, ursonic acid, curcumin, ajmalicine, novobiocin, silymarin and aranotin, piperine, gingerol, rosmarinic acid, and alpha terpinyl acetate
to Nsp15 viral protein and they might play a key role in inhibiting SARS-CoV-2 replication.
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Kumar et al
evaluated the ACE2 inhibitory effects of 10 essential oils. Geranium and lemon essential oils strongly reduced the human ACE2 levels in HT-29 cells from 17.68 ng/mL to 1.43 ng/mL and 4.34 ng/mL, respectively.
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Rasheed et al.
studied 49 early-stage critically-ill COVID-19 patients in Respiratory Care Units (RCU) of three hospitals in Baghdad, Iraq. 21 received convalescent plasma while 28 (control group) did not receive it. Patients who received convalescent plasma showed
reduced infection duration and showed less death rate. Also, all the patients who were given convalescent plasma showed high levels of SARS-CoV-2 IgG and IgM three days after plasma transfusion. Plasma from donors with high SARS-CoV-2 IgG levels and donors
with positive SRAS-CoV-2 IgM showed better therapeutic results than other donors.
·
Youssef et al.
A synthetic form of Vasoactive Intestinal Peptide (VIP) is currently in phase 2/3 placebo-controlled trials and has Fast Track Designation for treating Critical COVID-19 cases. Of the 21 consecutive patients with Acute Respiratory Failure in Critical
COVID-19 that were administered intravenous VIP, 19 showed improvement in lungs (17 in both and 2 in one lung). A mean increase of 292% was seen for PaO2:FiO2 ratio with complete remission from respiratory failure in 9 patients and ongoing improvement in 10.
In vitro anti-viral effect was seen using radiographic findings, oxygen consumption and other inflammatory markers.
CORONAVIROLOGY
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Mege, et al.
construct the phylogeny of the SARS corona virus that causes Covid-19 in various countries in the world by using the SARS Covid-19 gene database from the NCBI GenBank. The results showed that the phylogeny trees formed were obtained by 2 main monophyletic
groups. The presence of sequences from China in the 2 main monophyletic groups confirms that this virus originated in the Chinese epicenter.
·
Ma, et al.
created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung, heart and artery, the top tissues targeted by SARS-CoV-2. Our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide
vital insights into age-linked susceptibility to SARS-CoV-2, suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly.
DIAGNOSTICS
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Therchilsen et al compared the sensitivity of self-collected versus healthcare worker (HCW)-collected swabs for SARS-CoV-2 testing. A total of 109 participants were included,
and 19 participants had SARS-CoV-2-positive results. The diagnostic sensitivity of the self-collected and HCW-collected swabs was 84.2% and 89.5%, respectively.
·
Vaz et al validated the use of saliva as a biological sample for diagnosis of COVID-19. Participants presenting with signs/symptoms suggesting
SARS-CoV-2 infection underwent a nasopharyngeal swab and/or oropharyngeal swab, and saliva collection. The sensitivity and specificity of RT-PCR using saliva samples were 94.4% (95% CI 86.4–97.8) and 97.62% (95% CI 91.7–99.3), respectively. There was an overall
high agreement (96.1%) between the two tests.
·
Dust et al reported that choice of test did not compromise SARS-CoV-2 detection. Commercial assays
and lab developed tests for detection of SARS-CoV-2 exhibited 100% positive and negative agreement and there was no cross-reactivity with common respiratory viruses, including endemic coronaviruses.
ZOONOSES
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Musso et al.
detail the case of a domestic cat with clear clinical signs of pneumonia, confirmed by Rx imaging, that was found to be infected by SARS-CoV-2 using quantitative RT–qPCR from a nasal swab.
PUBLIC HEALTH RESPONSE
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Neto
et al. describe Covid-19 mobile applications available for download on smartphones. The cross-sectional analysis finds 86.6% of applications were developed in 2020, 98.1% were free, 94.2% did not have accessibility
for people with disabilities, and 32.7% were in English. The majority of applications were on “case monitoring” and “symptoms, prevention, and care”. Associations between the target audience and “symptoms, prevention, and care”, as well as patient monitoring
and professional training were noted.
HEALTH CARE RESPONSE
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Okonkwo et al.
present outcome data following pediatric elective surgeries in a region with high COVID-19 prevalence. Study finds the combined use of household self‐isolation, testing and screening questionnaires to have allowed for the re‐initiation of elective paediatric
surgery at high volume whilst maintaining pre‐COVID‐19 outcomes in children/young people undergoing surgery.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Christina Bancej, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin
Young, Chatura Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Alex Gilbert, Jessie Varga, Vanessa Zubach, Meenu Sharma, Kristyn Burak
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
PMC7403866; Angioedema and urticaria in a COVID-19 patient: A case report and review of the literature |
Abasaeed Elhag, SA, Ibrahim, et al |
JAAD Case Rep |
Clinical data| Données cliniques |
This article presents a case of angioedema and urticaria occurring in a 40-year-old previously healthy man presented
to the emergency department with a 1-day history of lip and bilateral eyelid swelling and a generalized pruritic rash. Before the symptoms occurred, he had a 5-day history of mild, nonproductive cough and dyspnea with low-grade fever. Nasopharyngeal swab result
for COVID-19 reverse transcriptase–polymerase chain reaction test was positive. Chest radiograph showed bilateral lower-zone opacities and infiltrations typical for COVID pneumonia of moderate severity. This article reviewed literature that described cutaneous
manifestations in COVID-19. Although urticarial lesions have been described in patients with COVID-19 pneumonia, associated angioedema was rarely reported. Concluded that urticaria and angioedema are often triggered by various viral or bacterial infections,
and COVID-19 infection is not an exception, adding a new member to the array of cutaneous manifestations of this enigmatic infection. |
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Abdollahi, A, Beigmohammadi, et al |
Journal of gastrointestinal and liver diseases : JGLD |
Clinical data| Données cliniques |
This editorials reports on COVID-19’s pathogenesis and suggest that critical cases of COVID-19 with poorer prognoses are characterized by evidence that
points to hemophagocytic lymphohistiocytosis (HLH). This study was conducted to examine the histopathological findings in patients who had passed away due to COVID-19. While conducting a pathological study on 11 randomly selected deceased patients
who were confirmed cases of COVID-19, and following a post-mortem core needle liver biopsy procedure, the authors found the presence of Kupffer cell hyperplasia and hemophagocytosis in the liver of two patients. HLH can be proposed
as the cause of such an observation. |
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Abraham, B, Nair, et al |
Biocybern Biomed Eng |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This paper investigates the effectiveness of multi-convolutional neural networks (CNN), a combination of several pre-trained CNNs, for the automated detection
of COVID-19 from X-ray images. The method was tested using two public datasets and achieved promising results on both the datasets. In the first dataset consisting of 453 COVID-19 images and 497 non-COVID images, the method achieved an AUC of 0.963 and an
accuracy of 91.16%. In the second dataset consisting of 71 COVID-19 images and 7 non-COVID images, the method achieved an AUC of 0.911 and an accuracy of 97.44%. The experiments performed in this study proved the effectiveness of pre-trained multi-CNN over
single CNN in the detection of COVID-19. |
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Abrams, MP, Coromilas, et al |
HeartRhythm Case Reports |
Clinical data| Données cliniques |
This report present a series of COVID-19-infected patients with preserved cardiac function who developed ARDS and refractory ventricular arrhythmias. And
reports onVT or VF as the primary cause of death in COVID-19 patients without previous evidence of significant structural heart disease. |
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Impact of the COVID-19 Pandemic on the U.S. Electricity Demand and Supply: An
Early View from Data |
Agdas, D, Barooah, et al |
IEEE Access |
Public Health response| Interventions de santé publique Economics | Économie |
This paper analyzed the electricity data until the end of May 2020, examining both electricity demand and variables that can indicate stress on the power
grid. Limited this study to three states in the U.S. California, Florida and New York. The results indicate that the effect of the pandemic on electricity demand is not a simple reduction, and there are noticeable differences among regions analyzed. The variables
that can indicate stress on the grid (e.g., daily peak and trough of the hourly demand, demand ramp rate, demand forecast error, and net electricity interchange) also conveyed mixed messages: some indicate an increase in stress, some indicate a decrease, and
some do not indicate any clear difference. Also provided a weather-correction method, applied to a small city-wide area in North Central Florida, and discussed the implications of the estimated changes in demand. The results indicate that a 10% (95% CI [2%,
18%]) increase in electricity demand is likely to have occurred due to COVID-19 for the city analyzed. |
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Covid-19: statutory means of scrutinizing workers' deaths and disease |
Agius, RM |
Occup Med (Lond) |
Public Health response| Interventions de santé publique |
This study assesses the adequacy of these statutory ( By law, covid-19 disease and deaths in workers may lead to coroners'
inquests and/or Health and Safety Executive (HSE) investigations) means to yield recommendations for prevention of acquiring covid-19 infection from work. The coroners' guidance allowed a wider range of reports of death than did the HSE and conformed better
with ONS data on covid-19 mortality by occupation. In the practitioner survey, 62 respondents considered a higher likelihood that reported covid-19 cases would have arisen from the scenario deemed unreportable as a 'dangerous occurrence' by HSE than the reportable
scenario (P < 0.001). On average there was only one coroner's report to prevent future death from occupational disease every year in England and Wales. The HSE dealt with a yearly average of 1611 reports of work-related disease including 104 on biological
agents, but has received about 9000 covid-19 reports. |
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A poisson autoregressive model to understand covid-19 contagion dynamics |
Agosto, A, Giudici, et al |
Risks |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We present a statistical model which can be employed to understand the contagion dynamics of the COVID-19, which can
heavily impact health, economics and finance. The model is a Poisson autoregression of the daily new observed cases, and can reveal whether contagion has a trend, and where is each country on that trend. Model results are exemplified from some observed series.
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
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Estimating the impacts of lockdown on Covid-19
cases in Nigeria |
Ajide, KB, Ibrahim, et al |
Transportation Research Interdisciplinary Perspectives |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
The study examines the extent to which lockdown measures impact on COVID-19 confirmed cases in Nigeria. Six indicators
of lockdown entailing retail and recreation, grocery and pharmacy, parks, transit stations, workplaces, and residential, are considered. The study established the key following findings: First, retail and recreation, grocery and pharmacy, parks, transit stations,
and workplaces are statistically significant and negatively signed as relevant predictors of the virus. Second, the impact of residential is positive and statistically significant at the conventional level. |
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Akhtar, N, Joshi, et al |
Infect Disord Drug Targets |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
This study attempted to design epitope based vaccine for combatting COVID-19 disease by analyzing the complete proteome
of the virus by using immuno-informatics tools. The study has predicted 5 peptide molecules that can act as potential candidate for epitope based vaccine development. Among the 5 selected epitopes, the peptide LRARSVSPK can be the most potent epitope because
of its high geometric shape complementarity score, low ACE and very high response to it by the world population (81.81% global population coverage). Further, molecular dynamic simulation analysis indicated the formation of stable epitope-MHCII complex. The
epitope LRARSVSPK was also found to be highly conserved among the SARS-CoV-2 isolated from different countries. |
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Akinbami, LJ, Vuong, et al |
Emerg Infect Dis |
Epidemiology| Épidémiologie Immunology | Immunologie |
This study estimated seroprevalence of severe acute respiratory syndrome 2 (SARS-CoV-2) among healthcare, first response,
and public safety personnel in Michigan. Of 16,403 participants, 6.9% had SARS-CoV-2 antibodies. In adjusted analyses, seropositivity was associated with exposure to SARS-CoV-2-positive household members ( aOR] 6.18, 95% CI 4.81-7.93) and working within 15
km of Detroit (aOR 5.60, 95% CI 3.98-7.89). Nurse assistants (aOR 1.88, 95% CI 1.24-2.83) and nurses (aOR 1.52, 95% CI 1.18-1.95) had higher likelihood of seropositivity than physicians. Working in a hospital emergency department increased the likelihood of
seropositivity (aOR 1.16, 95% CI 1.002-1.35). Consistently using N95 respirators (aOR 0.83, 95% CI 0.72-0.95) and surgical facemasks (aOR 0.86, 95% CI 0.75-0.98) decreased the likelihood of seropositivity. |
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Alambo, A, Gaur, et al |
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Public Health response| Interventions de santé publique |
This position paper proposed a novel framework for assessing the spatio-temporal-thematic progression of depression,
drug abuse, and informativeness of the underlying news content across the different states in the United States. The framework employed an attention-based transfer learning technique to apply knowledge learned on a social media domain to a target domain of
media exposure. Used neural semantic parsing, and background knowledge bases in a sequence of steps called semantic filtering. Achieved promising preliminary results on three variations of Bidirectional Encoder Representations from Transformers (BERT) model.
Compared the findings against a report from Mental Health America and the results showed that this fine-tuned BERT models performed better than vanilla BERT. |
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AlAteeq, DA, Aljhani, et al |
Journal of Infection and Public Health |
Healthcare Response | Réponse des soins de santé |
This cross-sectional study sought to explore depression and anxiety levels among healthcare providers during the COVID-19
outbreak in Saudi Arabia. The respondents represented various healthcare occupations: administrators (28.49%), nurses (26.29%), physicians (22.11%), non-physician specialists (13.94%), technicians (6.77%), and pharmacists (2.30%). The majority of them were
male (68.1%). More than half of them had depressive disorder (55.2%), which ranged from mild (24.9%), moderate (14.5%), and moderately severe (10%) to severe (5.8%). Half of the sample had generalized anxiety disorder (51.4%), which ranged from mild (25.1%)
and moderate (11%) to severe (15.3%). Multivariate analysis showed that males were significantly less predicted to have anxiety (Beta = −0.22, P-value <0.04), 30–39 years age group were significantly more predicted to have depression and anxiety group (Beta
= 0.204, P-value <0.001 and beta = 0.521, P-value <0.003 respectively), and nurses had significantly higher mean score of anxiety (Beta = 0.445, P-value <0.026). |
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Alatrany, SSJ |
International Journal of Psychosocial Rehabilitation |
Public Health response| Interventions de santé publique |
The current study aimed to examine the view of the general public of stigma toward people with COVID-19 in Iraq. The
findings showed that the participants generally agreed people could be subjected to stigma if they have COVID-19. There was no significant difference between males and females. In addition, people who have confirmed COVID-19 patients in their family or of
friend reported high possibility of stigma. |
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Alay, I, Yildiz, et al |
J Obstet Gynaecol Res |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study observed the clinical course of symptomatic pregnant women diagnosed with or suspected of having COVID-19.
The mean duration of hospitalization was 6.1 ± 3 days. The gestational age of the patients ranged from 6w2d to 40w2d. Thirty-five patients' CT scan findings suggested viral pneumonia. Four patients delivered vaginally, and 10 patients underwent a cesarean
section during the study period. Four of the cesarean deliveries were indicated due to COVID-19 hypoxemia-related fetal distress. Four patients were admitted to the intensive care unit (ICU) after the cesarean section. |
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Estimates of dynamics of the COVID-19 pandemic and of its impact on the economy |
Albu, LL, Preda, et al |
Romanian Journal of Economic Forecasting |
Economics | Économie |
This study assessed the impact of COVID19 pandemic impact on the economic growth. The study proposed an estimation-simulation
model to analyse the dynamics of the spread of epidemic among the population, and built a model with differential equations for a special logistic time-function, which resulted in certain key-values and four phases of its evolution. Moreover, by simulating
the daily dynamics of pandemic at three levels (world, EU, and Romania) we estimated the impact of pandemic on the economic growth until the end of this year. |
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Alessandri, G, Filosa, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
This study tested a theoretical model with moral disengagement, a mediator, and generalized social trust (GST), a mediator
and a moderator of the relationship between personality traits and rule-respecting behaviors (i.e., social distancing and stay-at-home), during the coronavirus disease 2019 (COVID-19) outbreak in Italy. The data were collected on 1520 participants (61% males).
General results are threefold: (1) moral disengagement mediated the relationship between emotional stability, narcissism, psychopathy, and social distancing; (2) among components of GST, trust in Government mediated the relationship between psychopathy and
social distancing; trust in known others mediated the relationship between emotional stability, agreeableness, and Machiavellianism with total number of exits; trust in unknown others mediated the relationship of emotional stability, agreeableness, conscientiousness,
and psychopathy with average daily number of exits; (3) GST moderated the indirect effect of personality traits on rule-respecting behaviors through moral disengagement. |
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On global dynamics of COVID-19 by using SQIR type model under non-linear saturated
incidence rate |
Algehyne, EA, Din, et al |
Alexandria Engineering Journal |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper investigates a new mathematical SQIR model for COVID-19 by means of four dimensions; susceptible, quarantine,
infected and recovered (SQIR) via Non-linear Saturated Incidence Rate. First of all the model is formulated in the form of differential equations. Disease-free, endemic equilibriums and Basic Reproduction Number are found for the said model. Local Stability
is analyzed through Jacobean Matrix while Lyapunov Function is constructed for the study of Global Stability of the Model. Using nonstandard finite difference method, numerical results are simulated. By Simulation, we mean how protection, exposure, death and
cure rates affect the Susceptible, Quarantined, Infected and recovered population with the passage of time. © 2020 Faculty of Engineering, Alexandria University |
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Alhajeri, HM, Almutairi, et al |
Energies |
Public Health response| Interventions de santé publique Economics | Économie |
The present paper reports the impact of the Covid-19 pandemic on the electricity peak load and power generation in
the State of Kuwait during the partial and full curfews imposed in March, April and May 2020. Comparison of measured peak demand for 2019 and 2020 with predicted peak demand for 2020 has: (i) enabled an accurate evaluation of residential energy consumption
in the state of Kuwait at nearly 18 MWh yearly the highest energy consumption per capita in the world, (ii) shown that the imposition of the curfews to reduce the spread of COVID-19 caused a fall in the demand for electrical power of 17.6% compared with the
expected demand and (iii) quantified the reduction in CO2, NOx and CO pollutant emissions produced by power plants due to less fuel being consumed. |
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Ali, J, Khan, et al |
Journal of Public Affairs |
Public Health response| Interventions de santé publique Economics | Économie |
This paper attempts to analyse the impact of COVID-19 lockdown on wholesale prices of the agricultural commodities
particularly fruits and vegetables in the Union Territory of Jammu and Kashmir, India. The analysis of the difference in the weighted average wholesale prices across markets and commodities has shown a mixed response. The most hydrating perishable fresh fruits
and vegetables with high water content have faced a significant decline in wholesale prices during the lockdown. On the contrary, other perishable fruits and vegetables have realized a gain in the average wholesale prices. The weighted average wholesale price
has also declined over the phases of the lockdown. |
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A new self-reported assessment measure for COVID-19 anxiety scale (CDAS) in Iran:
A web-based study |
Alipour, A, Ghadami, et al |
Iranian Journal of Public Health |
Public Health response| Interventions de santé publique |
This study was conducted to instruct Corona Disease Anxiety Scale (CDAS) to measure the level of anxiety, during the
prevalence of the COVID-19 in Iran. 318 individuals (aged from 18 to 60 years old) completed the CDAS and the General Health Questionnaire (GHQ) onlineCDAS had a good internal consistency (α=0.91) and good convergent validity, correlating with the GHQ-28 (r=0.49,
P>0.01). Exploratory analysis revealed psychological and physical factors. This scale is reliable and valid scale for measuring Corona anxiety in non-clinical Iranian population. |
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Severe colon ischemia in patients with severe coronavirus-19 (COVID-19) |
Almeida Vargas, A, Valentí, et al |
Rev Esp Enferm Dig |
Clinical data| Données cliniques |
COVID-19 is associated with severe coagulopathy. We present three cases of colonic ischemia that can be attributed
to the hypercoagulable state related with SARS-CoV2 and disseminated intravascular coagulation. Three males aged 76, 68 and 56 with respiratory distress presented episodes of rectal bleeding, abdominal distension and signs of peritoneal irritation. Endoscopy
(case 1) and computed tomography angiography revealed colonic ischemia. One patient (case 2) in which a computed tomography (CT) scan showed perforation of the gangrenous cecum underwent surgery. D-dimer levels were markedly increased (2,170, 2,100 and 7,360
ng/ml) in all three patients. All three patients died shortly after diagnosis. |
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Alnashri, H, Aljohani, et al |
IDCases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Data on multisystem inflammatory syndrome in children (MIS-C) related to coronavirus disease-19 (COVID-19) is increasing
in the current COVID-19 pandemic. We present a 16 year old male who was hospitalized in July 2020 under adult medical service due to Kawasaki-like disease symptoms. Diagnosis of MIS-C related to COVID-19 was established by clinical features, elevated inflammatory
markers, and positive SARS−COV 2 immunoglobulin G. We encourage all clinicians especially who practice adult medicine to be familiar with signs and symptoms of MIS-C to avoid delayed diagnosis and complications. © 2020 The Author(s) |
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Alquézar-Arbé, A, Piñera, et al |
Emergencias |
Healthcare Response | Réponse des soins de santé |
This study estimated the impact of the coronavirus disease 2019 (COVID-19) pandemic on the organization of Spanish
hospital emergency departments (EDs). A total of 246 (87%) responses were received. The majority of the EDs organized a triage system, first aid, and observation wards; areas specifically for patients suspected of having COVID-19 were newly set apart. The
nursing staff was increased in 83% of the EDs (with no subgroup differences), and 59% increased the number of physicians (especially in large hospitals and locations where the COVID-19 incidence was high). Diagnostic tests for the severe acute respiratory
syndrome coronavirus 2 were the resource the EDs missed most: 55% reported that tests were scarce often or very often. Other resources reported to be scarce were FPP2 and FPP3 masks (38% of the EDs), waterproof protective gowns (34%), and space (32%). More
than 5% of the physicians, nurses, or other emergency staff were on sick leave 20%, 19%, and 16% of the time. These deficiencies were greatest during the last half of March, except for tests, which were most scarce in the first 15 days. |
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Al-Saud, H, Al-Romaih, et al |
Ann Saudi Med |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study demonstrated the capacity of a modified DNA extraction kit for automated viral RNA extraction and detection
using a platform suitable for mass testing. Automated RNA extraction on serial dilutions SARS-COV-2 achieved successful one-step RT-qPCR detection down to 60 copies using the commercial kit assay and less than 30 copies using the in-house primer-probe assay.
Moreover, RT-qPCR detection was successful after automated RNA extraction using this modified protocol on 12 patient samples of SARS-COV-2 collected by nasopharyngeal swabs and stored in viral transport media. |
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Al-Zahrani, A |
Natural Product Communications |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In the present study, more than 51 phytochemicals of J. procera were docked against the main protease of COVID-19.
Rutin gave the highest interaction score among all the phytochemicals and the commercially available antiviral drugs. Lopinavir showed the second highest binding score. Rutin and lopinavir were further investigated using homology models of COVID-19. Rutin
showed a better inhibition score in 9 of the 11 of homology models compared with lopinavir. Analysis of ligand-protein interaction contacts revealed that 3 residues (Glu166, Gly143, and Thr45) of the main protease formed hydrogen bonds with rutin. |
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Amato, M, Werba, et al |
Vaccines |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study investigated whether anti-influenza vaccination plays a role in minimizing the diffusion of COVID-19 in
the Italian population aged 65 and over. At univariate analyses, the influenza vaccination coverage rates correlated negatively with all COVID-19 outcomes (Beta ranging from −134 to −0.61; all p < 0.01). At multivariable analyses, influenza vaccination coverage
rates correlated independently with SARS-CoV-2 seroprevalence (Beta (95% C.I.): −130 (−198, −62); p = 0.001), hospitalizations for COVID-19 symptoms (Beta (95% C.I.): −4.16 (−6.27, −2.05); p = 0.001), admission to intensive care units for reasons related to
SARS-CoV-2 (Beta (95% C.I.): −0.58 (−1.05, −0.12); p = 0.017), and number of deaths attributable to COVID-19 (Beta (95% C.I.): −3.29 (−5.66, −0.93); p = 0.010). The R2 observed in the unadjusted analysis increased from 82% to 159% for all the considered outcomes
after multivariable analyses. |
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Anand, P, Yadav, et al |
European journal of pediatrics |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study described the clinicodemographic profile and viral load in neonates born to COVID 19 positive mothers.
Of 2947 deliveries, 69 mothers were COVID 19 positive (2.3%), with 1 abortion, 2 macerated stillbirths and 2 fresh stillbirths as pregnancy outcomes. Of 65 tested neonates, 10.7% (7) were confirmed COVID 19 positive by RTPCR (reverse transcriptase-polymerase
chain reaction). Viral load (cycle threshold, Ct of E, RDRp) in neonates was comparable with the Ct reported from adults; however, neonates had milder clinical manifestations. All 7 neonates who tested positive for COVID 19 were subsequently discharged. Six
of the 7 neonates were asymptomatic and 1 neonate needed respiratory support (indication being prematurity) which resolved after 48 h. Maternal and neonatal comparison of Ct of E and RdRp gene was statistically non-significant (25.97 vs 19.68, p = 0.34 and
26.5 vs 25.0, p = 0.84). Viral loads of mothers with COVID 19 positive neonates compared with mothers with COVID 19 negative neonates for E and RdRp gene were also statistically non-significant (25 vs 27.19, p = 0.63 and 19.6 vs 27.6, p = 0.08). The majority
(93%) of neonates tested later than 48 h (roomed in with mother and breastfed) tested negative. |
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Sectoral Employment Dynamics in Australia and the COVID-19 Pandemic |
Anderson, H, Caggiano, et al |
Australian Economic Review |
Economics | Économie |
We develop a multivariate time series model of employment in 19 sectors for Australia. We use this model to determine
the long-run effect of a 1% increase in economic activity in any chosen sector on aggregate employment. Our findings point to manufacturing and construction sectors as those that generate the largest positive spillovers for the aggregate economy. Moreover,
we provide an interactive web-based app that produces our model's forecasts based on any user-specified scenario. As the restrictions associated with the COVID-19 pandemic evolve, the sectoral employment multipliers together with these interactive tools will
provide useful information for policymakers. © 2020 The University of Melbourne, Melbourne Institute: Applied Economic & Social Research, Faculty of Business and Economics |
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Andrews, PLR, Cai, et al |
J Gastroenterol Hepatol |
Clinical data| Données cliniques |
This study examined the incidence of nausea (N) and vomiting (V) during infection before defining potential mechanisms.
Estimated that the overall incidence of nausea (median 10.5%), although variable, is comparable to diarrhoea. Proposed that emetic mechanisms are activated by mediators released from the intestinal epithelium by SARS-CoV-2 modulate vagal afferents projecting
to the brainstem and after entry into the blood, activate the area postrema (AP). The receptor for spike protein of SARS-CoV-2, angiotensin 2 converting enzyme (ACE2), and transmembrane protease serine (for viral entry) are expressed in upper GI enterocytes,
ACE2 is expressed on enteroendocrine cells (EECs), and SARS-CoV-2 infects enterocytes but not EECs (studies needed with native EECs). The resultant virus-induced release of epithelial mediators due to exocytosis, inflammation and apoptosis provides the peripheral
and central emetic drives. Additionally, data from SARS-CoV-2 shows an increase in plasma angiotensin II (consequent on SARS-CoV-2/ACE2 interaction), a centrally (AP) acting emetic, providing a further potential mechanism in COVID-19. |
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Exploratory analysis of internet search trends during the COVID-19 outbreak |
Aquino-Canchari, C, Chávez-Bustamante, et al |
Revista Cubana de Informacion en Ciencias de la Salud |
Public Health response| Interventions de santé publique |
This study conducted an exploratory analysis of Internet search trends during the 2019 coronavirus disease outbreak.
The search term used to know this pandemic was “coronavirus”, the most searched symptom was “fever”, followed by “sore throat” and “cough”, in addition, the interest of users to know the transmission routes of the acute respiratory syndrome coronavirus 2.
As for preventive measures, the most searched term was “stay home”, followed by “facial masks”, “social distancing” and “washing hands”. |
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Arbel, Y, Fialkoff, et al |
J Atten Disord |
Clinical data| Données cliniques |
The current study attempts to investigate the relationships between infection, mortality and recovery rates from coronavirus
and the prevalence of ADHD at the US statewide level. Based on information from 2011 regarding the prevalence of ADHD across the US by state, findings suggest that, while there are no correlations between ADHD and population size, infection and mortality
rates from coronavirus, recovery rates (recovery-population ratio) rise with the prevalence of ADHD. Consequently, a possible explanation is that in coping with the disease, ADHD might provide an evolutionary advantage. |
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Argyraki, A, Grigorakos, et al |
Medicina (Lithuania) |
Clinical data| Données cliniques |
This study reports the case of a 62-year-old patient with severe membranoproliferative glomerulonephritis who had been
receiving a high burden of immunosuppression until four months before the COVID-19 infection. He developed severe disease with acute respiratory failure requiring mechanical ventilation. After treatment with hydroxychloroquine and azithromycin, despite his
low chances, he gradually recovered and survived. |
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Changes in urban mobility in Sapporo city, Japan due to the Covid-19 emergency
declarations |
Arimura, M, Ha, et al |
Transportation Research Interdisciplinary Perspectives |
Public Health response| Interventions de santé publique |
This study aims to interpret the change in the population density of Sapporo city in the emergency's period declaration
using big data obtained from mobile spatial statistics. The results indicate that, in the time of refraining from traveling, the city's residents have been more likely to stay home and less likely to travel to the center area. This has led to a decrease of
up to 90% of the population density in crowded areas. The study's outcomes partly explain the statement of reducing 70%–80% of contact between people in line with the purpose of the emergency declaration. |
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Do COVID-19 policies affect mobility behaviour? evidence from 75 Canadian and American
cities |
Armstrong, DA, , et al |
Canadian Public Policy |
Public Health response| Interventions de santé publique |
This study provides a comparative analysis of COVID-19 policy measures and citizen mobility patterns in Canada and
the United States. This research constructed a new measure of the aggressiveness of COVID-19 policies in 75 Canadian and American cities and estimated the effect of these policies on mobility patterns in each city. While the authors found considerable heterogeneity
among cities in policy aggressiveness and policy effects, also found few systematic differences between Canadian and American cities: in both countries, average policy aggressiveness is similar, and found clear effects of policy on subsequent mobility patterns
in both countries. |
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Arribas-Cobo, P, Bernabé-Villena, et al |
Enfermeria Nefrologica |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to describe the experience of a Madrid hospital haemodialysis unit during the first
month of the SARS-CoV-2 pandemic, both in relation to patients and healthcare personnel. A high prevalence of positive COVID-19 was detected in patients in the dialysis unit, highlighting the high number of asymptomatic patients detected by PCR screening.
Some healthcare professionals presented some type of symptoms corresponding to the COVID-19 disease, however, few cases were detected with positive PCR. |
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COVID-19 in Parkinson's disease: Report on prevalence and outcome |
Artusi, CA, Romagnolo, et al |
Parkinsonism and Related Disorders |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study estimated the prevalence of COVID-19 in a large population of Parkinson's disease (PD) patients and compared
the infection rate with the general population of the same region of Italy. Eight PD patients, meaning 0.57% of interviewed, were found to be positive to COVID-19. 75% of PD patients (n = 6/8) died because of COVID-19, while the mortality rate in the general
population of Piedmont was 11.53% (n = 3186/27,622). PD symptoms worsened in all patients, early before or early after the onset of infection signs, which consisted in fever (100% of patients), weakness (43%), muscle pain (29%), dyspnea (29%), and cough (14%).
Interestingly, one patient developed disabling dyskinesia as the presenting symptom of the infection. All patients were hospitalized, and three were already institutionalized at the moment of infection. All were treated with levodopa, alone or in combination
with dopamine agonists. |
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Asemahagn, MA |
Tropical Medicine and Health |
Healthcare Response | Réponse des soins de santé |
This cross-sectional study aimed to assess factors determining the knowledge and prevention of healthcare worker (HWs)
towards COVID-19 in the Amhara Region, Ethiopia. From 398 HWs, 231(58%), 225(56%), 207(53%), and 191(48%) were males, from rural area, aged ≥ 34 years and nurses, respectively. About 279(70%) HWs had good knowledge of COVID-19 followed by 247(62%) good prevention
practices. Age < 34 years (AOR = 2.14, 95% CI = 1.25-3.62), rural residence (AOR = 0.44, 95% CI = 0.26-0.70), access to infection prevention (IP) training (AOR = 2.4, 95% CI = 1.36-4.21), presence of IP guideline (AOR = 2.82, 95% CI = 1.64-4.62), and using
social media (AOR = 2.51, 95% CI = 1.42-4.53) were factors of knowledge about COVID-19. Whereas, rural residence (AOR = 0.45, 95% CI = 0.31-0.75), facility type (AOR = 0.40, 95% CI = 0.28-0.89), access to IP training (AOR = 2.32, 95% CI = 1.35-4.16), presence
of IP guidelines (AOR = 2.10, 95% CI = 1.21-3.45), knowledge about COVID-19 (AOR = 2.98, 95% CI = 2.15-5.27), having chronic illnesses (AOR = 2.0, 95% CI = 1.15-3.75), lack of protective equipment (PPE) (AOR = 0.42, 95% CI = 0.32-0.74), and high workload (AOR
= 0.40, 95% CI = 0.36-0.87) were factors of COVID-19 prevention. |
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Aumpan, N, Nunanan, et al |
JGH Open |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to determine the prevalence of gastrointestinal manifestations of COVID-19 patients in Thailand and
review important aspects of this disease in Association of Southeast Asian Nations. A total of 352 COVID-19 tests were performed, and 40 patients with positive tests were studied. The mean age was 30.5 years, and 55% were female. Most (82.5%) had no underlying
diseases. Comorbidities were associated with severe COVID-19 (OR] 29.93; 95% CI] 2.31–388.40, P = 0.009). Gastrointestinal symptoms were present in 12 patients (30%). The most common presenting symptoms were anorexia (17.5%) and diarrhea (15%). Gastrointestinal
symptoms developed before (9.1%), concurrent with (63.6%), and after (27.3%) respiratory symptoms. Diarrhea was significantly associated with severe COVID-19 (OR 38.52; 95% CI 3.11–476.70, P = 0.004). Twenty-four patients (60%) received antiviral drugs; 40%
had only supportive care. Only one patient required intensive care. No patient died. |
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32920570; Out-patient management of patients with COVID-19 on home isolation |
Ayaz, CM, Dizman, et al |
Le infezioni in medicina |
Clinical data| Données cliniques |
The records of COVID-19 first admission clinic were retrospectively reviewed to identify the COVID-19 patients who
were followed on home isolation as outpatients between March 17, 2020 and April 18, 2020 in Ankara, Turkey. A total of 41 patients with COVID-19 were followed on home isolation without hospitalization. Twenty-four (58.5%) of 41 patients were female. Twenty-nine
(70.7%) patients were healthcare workers. The most common symptoms at admission were cough, myalgia/arthralgia, and loss of smell and/or taste. Fourteen (34.1%) patients were asymptomatic on the first admission. Anti-viral treatment was given to 27 (65.8%)
of 41 patients. Four of 41 patients were readmitted to the outpatient clinic and hospitalized. Three patients had worsening respiratory symptoms and pneumonia was detected in CT scans. One patient was hospitalized because of disseminated herpes zoster infection. |
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Baicus, C, Pinte, et al |
J Eval Clin Pract |
Healthcare Response | Réponse des soins de santé |
We performed a survey among Romanian physicians in order to see how many of them would administer prophylactically
hydroxychloroquine to themselves or to people close to them, and if they would participate to a randomized controlled trial. A total of 785 answers were collected. Nine physicians (1.1%) thought that there was clear evidence on prescribing hydroxychloroquine
prophylaxis, 375 (48%) considered the evidence acceptable, 348 (44.3%) considered it weak, whereas 53 (6.8%) answered there was no evidence. 59 (7.5%) respondents were determined to take it (of which 31 = 4% already took), 192 (24.5%) were inclined to take,
271 (34.5%) were not decided yet. 175 (22.3%) of respondents declared they (would) give the treatment to their close ones, and this decision was associated with a higher age (P = 0.003), and the opinion that there was evidence (P < 0.001). When asked about
the source of the treatment regimen, 286 (36.4%) indicated a scientific paper, while no scientific paper about the prophylaxis with hydroxychloroquine existed at that time. 718 (91.5%) considered a randomized clinical trial necessary (RCT), but only 333 (42.4%)
answered they would enrol in such a trial. There was only a very weak correlation (Kendall's tau _b = 0.255, P < 0.001) between the belief that an RCT is necessary and the willingness to enrol in such an RCT. |
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Bakhta, Athmane, Boiveau, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We propose a forecasting method for predicting epidemiological health series on a two-week horizon at the regional
and interregional level. The approach is based on model order reduction of parametric compartmental models, and is designed to accommodate small amount of sanitary data. The efficiency of the method is examined in the case of the prediction of the number of
hospitalized infected and removed people during the first pandemic wave of COVID-19 in France, which has taken place approximately between February and May 2020. Numerical results illustrate the promising potential of the approach. |
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32903223; Perception and practice of social distancing among Egyptians in COVID-19 pandemic |
Bakry, HM, Waly, et al |
Journal of infection in developing countries |
Public Health response| Interventions de santé publique |
A cross sectional study was conducted among 1,036 Egyptians using an online questionnaire between 5 and 10 May 2020.
There was significant association between the practice of social distancing and some sociodemographic factors as sex, age, education, working status, and place of residence at p value < 0.001 and with community of residence at p value 0.021. |
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Baltas, GN, Prieto, et al |
Computers, Materials and Continua |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this study, a Deep Neural Network approach using Monte Carlo is proposed for generating a database to train networks
for estimating the optimal parameters of a SIR epidemiology model. The number of total infected people as of April 7 in Spain is considered as input to the Deep Neural Network. The adaptability of the model was evaluated using the latest data upon completion
of this paper, i.e., April 14. The date range for the peak of infected people (i.e., active cases) based on the new information is estimated to be within 74 to 109 days after the first recorded case of COVID-19 in Spain. In addition, a curve fitting measure
based on the squared Euclidean distance indicates that according to the current data the peak might occur before the 86th day. Collectively, Deep Neural Networks have proven accurate and useful tools in handling big epidemiological data and for peak prediction
estimates. |
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Bartz, J |
Education Sciences |
Public Health response| Interventions de santé publique |
In the study presented below, I have followed up on the question of how disabled students experience inclusive higher
education at German universities in general and what individual experiences they have made in this context exactly. As expected, the current exceptional situation of the COVID-19 pandemic causes great difficulties, also and especially for the situation of
students with disabilities. More than 80% of the study participants assessed the current situation as very or extremely stressful |
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Importance of nonlinear
regression models in the interpretation of data from COVID-19 in Colombia |
Bastidas, JAO, Pita, et al |
Revista Habanera de Ciencias Medicas |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Article in Spanish. This study aimed to highlight the importance of the analysis of non-linear correlation models and
all the statistical inference procedures for the design of a mathematical model that allows the prediction of data based on the age of positive cases of COVID-19 in Colombia. With an R2 value of 0.9969 very close to 1 and a hypothesis test that guarantees
the veracity of the alternative hypothesis, the ideal mathematical model that aligns the growth data of COVID-19 is quadratic. The quadratic model is positive and increasing as long as the number of infections continue to grow; therefore, it is not an ideal
moment to speak of a flattening of the curve. If the growth is constant, the model could have an exponential trend. |
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Bayat, Niloofar, Morrin, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
The synthetic control method is an empirical methodology forcausal inference using observational data. By observing
thespread of COVID-19 throughout the world, we analyze the dataon the number of deaths and cases in different regions usingthe power of prediction, counterfactual analysis, and syntheticinterventions of the synthetic control and its extensions. Weobserve that
the number of deaths and cases in different re-gions would have been much smaller had the lockdowns beenimposed earlier and had the re-openings been done later, es-pecially among indoor bars and restaurants. We also analyzethe speculated impact of herd immunity
on the spread giventhe population of each region and show that lockdown policieshave a very strong impact on the spread regardless of the levelof prior infections. Our most up-to-date code, model, and data can be foundon github: this https URL |
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The C-C Chemokine Receptor Type 4 Is an Immunomodulatory Target of Hydroxychloroquine |
Beck, TC, Beck, et al |
Frontiers in Pharmacology |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Despite an abundance of empirical data, the mechanism(s) involved in the immunomodulatory activity of hydroxychloroquine
have not been characterized. Using the unbiased chemical similarity ensemble approach (SEA), we identified C-C chemokine receptor type 4 (CCR4) as an immunomodulatory target of hydroxychloroquine. The crystal structure of CCR4 was selected for molecular docking
studies using the SwissDock modeling software. In silico, hydroxychloroquine interacts with Thr-189 within the CCR4 active site, presumably blocking endogenous ligand binding. However, the CCR4 antagonists compound 18a and K777 outperformed hydroxychloroquine
in silico, demonstrating energetically favorable binding characteristics. Hydroxychloroquine may subject COVID-19 patients to QT-prolongation, increasing the risk of sudden cardiac death. The FDA-approved CCR4 antagonist mogalizumab is not known to increase
the risk of QT prolongation and may serve as a viable alternative to hydroxychloroquine. Results from this report introduce additional FDA-approved drugs that warrant investigation for therapeutic use in the treatment of COVID-19. |
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Belhassan, A, En-Nahli, et al |
Life Sci |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
A docking study was executed on eighteen imidazole derivatives based on 7-chloro-4-aminoquinoline against novel Coronavirus
(SARS-CoV-2). The result indicate that Molecules N° 3, 7 and 14 have more binding energy with SARS-CoV-2 main protease recently crystallized (pdb code 6LU7) in comparison with the other imidazole derivatives and the two drug; Chloroquine and hydroxychloroquine.
Because of the best energy of interaction, these three molecules could have the most potential antiviral treatment of COVID-19 than the other studied compounds. The structures with best affinity in the binding site of the protease have more than 3 cycles and
electronegative atoms in the structure. This may increase the binding affinity of these molecules because of formation of π-bonds, halogen interactions and/or Hydrogen bond interactions between compounds and the enzyme. So, compounds with more cycles and electronegative
atoms could have a potent inhibition of SARS-CoV-2 main protease. |
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Case numbers and challenges in southern bavarian primary care practices during
the COVID-19 pandemic |
Bergmaier, C, Schneider, et al |
Zeitschrift fur Allgemeinmedizin |
Healthcare Response | Réponse des soins de santé |
Article in German. In a cross-sectional survey we investigated the caseload and the perceived challenges in Southern
Bavarian primary care practices during the first phase of the pandemic. A total of 160 questionnaires were available for analysis (response rate 76 %). 92 % of participants had seen at least one patient with a SARS-CoV-2 infection, two colleagues saw more
than 100 infected patients; the median number was 10.63 % had at least one patient hospitalized and 31 % at least one death associated with SARS-CoV-2 infection. In contrast, only 23 % of the nursing homes looked after by the participants were affected by
infections; in individual nursing homes, however, there were numerous hospitalizations and deaths. In 18 % of practices at least one member of the team was tested positive for SARS-CoV-2. The most important challenges were the lack of protective equipment
and the adaptation of the practice process to the pandemic situation. With regard to a possible “second wave”, the need for protective equipment and a better flow of information were central issues. |
|
Bernardini, A, Ciconte, et al |
Int J Cardiol |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The aim of this study was to assess the effects of these drugs on QT interval and outcome in a COVID-19 population.
A total of 112 consecutive COVID-19 patients were included in this analysis and were divided in 3 groups according to the receiving therapeutic regimens: 19 (17%) patients in Group 1 (no treatment), 40 (36%) in Group 2 (HCQ only), 53 (47%) in Group 3 (HCQ/AZT).
A prolonged QTc interval was found in 61% of patients treated with HCQ alone or in combination with AZT, but only 4 (4%) patients showed a QTc > 500 ms. HCQ/AZT combination determined a greater increase of QTc duration compared to the other two strategies
(Group 3452 ± 26.4 vs Group 2436.3 ± 28.4 vs Group 1424.4 ± 24.3 ms, respectively; p < 0.001). Multivariate analysis demonstrated that HCQ/AZT combination (OR 9.02, p = 0.001) and older age (OR 1.04, p = 0.031) were independent predictors of QTc prolongation.
The risk increased with age (incremental utility analysis p = 0.02). Twenty patients (18%) died, and no cardiac arrest neither arrhythmic fatalities were documented. |
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Red blood cell morphology in patients with COVID-19-related anaemia |
Berzuini, A, Bianco, et al |
Blood Transfus |
Clinical data| Données cliniques |
Here we report on blood films examined from 20 patients with COVID-19-related anaemia who had been consecutively referred
for pre-transfusion testing or ABO typing. The analysis of blood smears obtained from patients with COVID-19-related anaemia showed several RBC shape abnormalities. The presence of a high frequency |
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Bienvenido-Huertas, D |
Energies |
Public Health response| Interventions de santé publique |
This study assesses the effect of improving building façades and thermal bridges. For this purpose, a case study is
assessed for all climate zones in Spain, both in current and future scenarios, considering operational patterns from the COVID-19 pandemic. The study shows that the application of energy conservation measures focusing on reducing the thermal transmittance
of façades and the linear thermal transmittance of thermal bridges has a more significant energy and environmental effect than other, more economical energy conservation measures that do not improve the effect of thermal bridges. Likewise, the application
of energy conservation measures to improve façades can reduce carbon dioxide emissions but are far from achieving the 90% reduction set by the European Union by 2050. Consequently, these measures should be combined with other measures. |
|
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Bolsen, T, Palm, et al |
Science Communication |
Public Health response| Interventions de santé publique |
This article reports the results from a study that evaluates the impact of exposure to framed messages about the origins
of COVID-19. We tested four hypotheses: two focusing on its origins as either zoonotic or human-engineered and two concerning the impacts of origin beliefs on the desire to penalize China or support increased funding for biomedical research. The results accentuate
the importance of finding ways to combat the spread of misinformation and conspiracy theories related to this global pandemic. |
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Clinical features and outcome of COVID-19 pneumonia in haemodialysis patients |
Bongiovanni, M, Savino, et al |
Infect Dis (Lond) |
Clinical data| Données cliniques |
In this report we describe the clinical features and the outcome of 8 haemodialysis patients who were hospitalised
for severe COVID-19 pneumonia with diffuse ground-glass opacity between 10 March and 8 May at ASST Rhodense Hospital, Milan Province, Italy, and were followed-up until death or recovery (defined as clinical recovery associated with two consecutive nasopharyngeal
swabs 24 h apart from each other). A high percentage of subjects died, confirming that these patients have an increased risk of infective complications and an impairment of immune system. |
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Bono, G, Reil, et al |
International Journal of Wellbeing |
Public Health response| Interventions de santé publique |
The study analyzes participants (n=86)using a short-term longitudinal study from prior to campus closure on March 10,
2020 to the end of the semester (May 2020), which was completed remotely. In particular, the study examines whether grit and gratitude at the start of semester predicts how much impact the pandemic had on the psychological, academic and financial functioning
as well as resilience of students toward the end of the semester. Overall results suggest that grit and gratitude can be promoted to protect college students’ subjective wellbeing and better cope with adversity of the pandemic. The study closes with suggestions
for intervention. |
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Borah, Manash Jyoti, Hazarika, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this article, for the analysis of Covid-19 progression in India, we present new insights to formulate a data-driven
epidemic model and approximation algorithm using the real data on infection, recovery and death cases with respect to weather in the view of mathematical variables. |
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Bourdas, DI, Zacharakis, et al |
Data Brief |
Public Health response| Interventions de santé publique |
In this study we focus on physical activity (PA) change in Greek adults over time, during each of the last four weeks
of lockdown in Greece. Overall PA change (from PRE to POST condition) ranged from -21.50% in G-I (Ph-I) to -5.03 in G-V (Ph-V); PA change in male subgroups ranged from -26.10% in Ph-I to -13.64 in Ph-V; in female subgroups it ranged from -17.42% in Ph-I to
-1.39 in Ph-V. Although the decline in overall PA is evident in all groups during each lockdown phase (p<0.05), the combination of our data demonstrates that towards the end of lockdown this decline showed a gradual decreasing tendency. |
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32720698; Rehabilitative of COVID-19 patients with acute lower extremity Ischemia and
amputation |
Brugliera, L, Spina, et al |
Journal of Rehabilitation Medicine |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study aimed to evaluate the clinical characteristics and rehabilitation management of patients who undergo amputation
for COVID-19-associated coagulopathy. |
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Burhamah, W, AlKhayyat, et al |
Journal of affective disorders |
Public Health response| Interventions de santé publique |
This cross-sectional study aimed to assess the impact of COVID19 outbreak on mental health in Kuwait, and to explore
the potential influencing risk factors. We had 4132 responders. Most were females (69.31%), married (59.37%), between the age of 21-30 (23.84%) and non-smokers (81.46%). Only (7.96%) had a positive past psychiatric history, (32.04%) had a past history of a
chronic medical disease. During the outbreak most of the responders lost their jobs (39.21%) and only (12.83%) were attending work regularly, only (6.82%) worked in the healthcare sector. 59.27% report increased social media use compared to before the lockdown.
When asked about their daily time spent following COVID19-related news, most (37.8%) spend more than 2 hours and (7.74%) spend more than 4 hours. The overall prevalence of depressive symptoms was (30.13%) and the prevalence of anxiety symptoms was (25.28%). |
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Burungale, MD, Chintamani, et al |
International Journal of Psychosocial Rehabilitation |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study aimed to investigate the short term effectiveness of dedicated prone lying along with physiotherapy in subjects
with covid-19 an interventional study. This is an experimental study conducted on 24 Covid positive subjects who were given regular chest physiotherapy including deep breathing exercises, segmental breathing exercises, and chest expansion exercises and dedicated
prone lying. The results demonstrated that: SP02, Respiratory rate, chest expansion measurements and Heart rate showed significant changes with p value <0.05, <0.05, <0.05 and <0.05 of Group A, and<0.01, <0.01, <0.05, <0.05 in group B. The treatment showed
significant improvement in Group A with all the outcome measures, and extremely significant improvement in Group B, Hence Dedicated prone lying along with regular chest physiotherapy showed great improvement in respiratory parameters. |
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Cabezón-Gutiérrez, L, Custodio-Cabello, et al |
Cancer treatment reviews |
Epidemiology| Épidémiologie Immunology | Immunologie |
Here we present the results of prevalence of IgG and IgM antibodies against SARS-CoV-2 in cancer patients from the
University Hospital of Torrejón (Torrejón de Ardoz, Madrid, Spain). We analyzed the serological test results of 229 cancer patients. We estimated an overall seroprevalence (IgG or IgM positive) of 31.4%. The probability of SARS-CoV-2 seropositivity was similar
between men and women, type of treatment and cancer stage. The probability of seropositivity was significantly higher in cancer patients with pneumonia compared with cancer patients without pneumonia (OR) 7.65 95% CI 1,85–31,58]). |
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Behavioral and psychological effects of coronavirus disease-19
quarantine in patients with dementia |
Cagnin, A, Di Lorenzo, et al |
Frontiers in Psychiatry |
Public Health response| Interventions de santé publique |
The aim of this study was to assess modifications of neuropsychiatric symptoms during quarantine in patients with dementia
and their caregivers. A total of 4,913 caregivers participated in the survey. Increased BPSD was reported in 59.6% of patients as worsening of preexisting symptoms (51.9%) or as new onset (26%), and requested drug modifications in 27.6% of these cases. Irritability,
apathy, agitation, and anxiety were the most frequently reported worsening symptoms and sleep disorder and irritability the most frequent new symptoms. Profile of BPSD varied according to dementia type, disease severity, and patients’ gender. Anxiety and depression
were associated with a diagnosis of AD (OR 1.35, CI: 1.12–1.62), mild to moderate disease severity and female gender. DLB was significantly associated with a higher risk of worsening hallucinations (OR 5.29, CI 3.66–7.64) and sleep disorder (OR 1.69, CI 1.25–2.29),
FTD with wandering (OR 1.62, CI 1.12–2.35), and change of appetite (OR 1.52, CI 1.03–2.25). |
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Candeiro, GTM, Gavini, et al |
Brazilian oral research |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to assess Brazilian endodontists' level of knowledge about COVID-19 and examine its professional
repercussions. A total of 2,135 participants responded to the questionnaire, and all five Brazilian regions were represented in the sample. A total of 98.50% of endodontists reported that dental procedures can transmit COVID-19. Complete social distancing
was practiced by 96.68% of the participants, and approximately 25% knew someone who had COVID-19. Moreover, in their daily practice, 72.13% of them implemented biosecurity measures that are ineffective in preventing COVID-19. Furthermore, 91.7% of them reportedly
suspended elective dental procedures. Only 55.69% of them reported that they performed only emergency procedures in their workplaces. Those who believed that COVID-19 cannot be transmitted during dental procedures were less knowledgeable about the symptoms
of COVID-19 (p = 0.0095). Endodontists who believed that personal protective equipment cannot prevent contamination were more knowledgeable about the symptoms of COVID-19 than their counterparts (p = 0.0003). |
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32921713; Hospital Acquired Infections in COVID-19 patients in sub intensive care
unit |
Castaldi, S, Luconi, et al |
Acta bio-medica : Atenei Parmensis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study is to assess the association among species of bacteria and to identify the presence of clusters
of patients in sub intensive care unit with different profiles of infection, and to study the relationship between such profiles and patient demographics (gender, age), kind of investigations and material used to detect the infection. The findings need to
analyse a bigger amount of data in the same setting to make evident that it is constant the infection only with Escherichia coli and Staphylocossus epidemidis and a third case in which more bacteria are inlvolved. |
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Cerbin-Koczorowska, M, Waszyk-Nowaczyk, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
This study aimed to evaluate the preparedness of Polish pharmacy employees for patient education on the new threat.
The study was conducted using the mystery shopper method. Two interviewers phoned 90 randomly chosen community pharmacies throughout Poland and presented some inquiries on the SARS-CoV-2. Pharmacists devoted more time to patients than pharmacy technicians
(2:22 vs. 1:54), and the information they provided was significantly more comprehensive (p = 0.006). The majority of respondents provided an evidence-based recommendation on prevention, symptoms, and management of SARS-CoV-2; however, the scope of advice significantly
varied. Community pharmacy staff often expressed their concern about the lack of time to address patients’ questions adequately. No statistically significant differences were found in recommendations provided by chain and non-chain pharmacy staff. |
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Chatterjee, AN, Al Basir, et al |
Computational and mathematical methods in medicine |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We propose and analyze a mathematical model for investigating the effect of CTL responses over the viral mutation to
control the viral infection when a postinfection immunostimulant drug (pidotimod) is administered at regular intervals. Dynamics of the system with and without impulses have been analyzed using the basic reproduction number. This study shows that the proper
dosing interval and drug dose both are important to eradicate the viral infection. |
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Chen, F, Wang, et al |
Medicine (Baltimore) |
Clinical data| Données cliniques Public Health response| Interventions de santé publique |
We explored the psychological changes in suspected patients during the COVID-19 epidemic and obtained evidence for
early psychological guidance and intervention in this group. A total of 31 inpatients with suspected COVID-19 were identified at our hospital. Among the patients, 32.3% had symptoms of depression and 19.4% had symptoms of anxiety. Levels of anxiety and fear
varied. Overall, 50% of confirmed patients had symptoms, with 30.8% classified as mild, 15.4% classified as moderate, and 3.8% classified as severe. During the COVID-19 epidemic, suspected and diagnosed patients had different levels of mental health problems.
Diagnosed patients had more visible symptoms. The performance of suspected patients was higher, but their mental state was more polarized. It may thus be important to monitor the psychological state of suspected patients as early as possible to enable timely
interventions that promote psychological rehabilitation. |
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Chen, GQ, Luo, et al |
Journal of infection in developing countries |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We analyzed the clinical characteristics of COVID-19 fecal/perianal swab nucleic acid-positive patients in our hospital
and evaluated the effect of SARS-CoV-2 on the gastrointestinal tract. Fecal/perianal swabs of 53.61% (52/97) patients were positive including 31 males (59.62%) and 21 females (40.38%). The negative group had more females than males (P = 0.001). The distribution
of case classification based on the most severe condition observed after admission was different between groups: five (5.15%) critical type patients were all from the positive group (P = 0.029). There was no statistical difference in clinical manifestations
between the groups. In the positive group, the mean nucleic acid-negative conversion time was 14.13 ± 8.61 days, which was significantly later than the negative group (6.98 ± 5.16 days; P < 0.001). In the positive group, 92% (48/52) had nucleic acid-negative
conversion with a mean nucleic acid-negative conversion time of 22.58 ± 10.30 days. Among them, 41 (78.85%) cases were delayed compared with pharynx/nasal swab nucleic acid-negative conversion time. |
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Chen, J, Liu, et al |
Social psychiatry and psychiatric epidemiology |
Healthcare Response | Réponse des soins de santé |
This cross-sectional study was conducted to evaluate the status of depression and anxiety of healthcare workers and
to explore the risk factors during the outbreak of COVID-19 in China. There were 902 questionnaires received between February 9, 2020 and February 11, 2020. The proportion of healthcare workers with symptoms of moderate/severe anxiety and moderate/severe depression
were 16.63% and 18.29%, respectively. The increased workload, respiratory symptoms, digestive symptoms, having done specific test(s) related to COVID-19, having family member needs to be taken care of, negative coping style, and job burnout were the independent
risk factors of anxiety. |
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Chen, X, Liu, et al |
Omega (Westport) |
Public Health response| Interventions de santé publique |
We conducted an online survey of 917 participants to assess the media involvement and other potential factors (empathy,
sympathy and affect) which might affect death anxiety. Correlation analysis and mediation models were conducted to examine the relationship between media involvement and death anxiety, and the possible mediating roles of empathy, sympathy, and affect. It was
found that media involvement was positively associated with death anxiety. Empathy, sympathy, and negative affect played mediating roles between them. However, empathy and sympathy act differently in the association, as empathy could lead to the increase of
negative affect, while sympathy did not. |
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Influence of traveller risk perception on the willingness to travel in a major epidemic |
Chen, X, Xia, et al |
International Journal of Sustainable Development and Planning |
Public Health response| Interventions de santé publique |
This paper aims to disclose how the willingness to travel is affected by the risk perception and travellers' familiarity
with the destination in a major epidemic. The results show that, under COVID-19, the traveller risk perception is negatively correlated with the willingness to travel, and the traveller familiarity with the destination regulated the negative correlation. It
also unveils the traveller risk perception is enhanced by the number of changes of transport vehicles, the length of travel time, and the degree of epidemic impact on the destination, but suppressed by the risk tolerance of potential travellers. |
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Chen, Y, Tong, et al |
PLoS pathogens |
Clinical data| Données cliniques Immunology | Immunologie |
We continuously monitored the serum IgM and IgG responses specific to four SARS-CoV-2 related antigens, including the
nucleoprotein (NP), receptor binding domain (RBD), S1 protein, and ectodomain (ECD) of the spike protein among non-severe and severe COVID-19 patients for seven weeks since disease onset. Most patients generated humoral responses against NP and spike protein-related
antigens but with their distinct kinetics profiles. Combined detection of NP and ECD antigens as detecting antigen synergistically improved the sensitivity of the serological assay, compared to that of using NP or RBD as detection antigen. 80.7% of convalescent
sera from COVID-19 patients revealed that the varying extents of neutralization activities against SARS-CoV-2. S1-specific and ECD-specific IgA responses were strongly correlated with the neutralization activities in non-severe patients, but not in severe
patients. Moreover, the neutralizing activities of the convalescent sera were shown to significantly decline during the period between 21 days to 28 days after hospital discharge, accompanied by a substantial drop in RBD-specific IgA response. |
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Cheng, L, Xu, et al |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University |
Epidemiology| Épidémiologie |
This study aimed to understand the distribution patterns and the factors influencing the interval between entry of
mainland China and diagnosis in imported COVID-19 cases in Guangdong Province to provide evidence for formulating and implementing effective control measures. A total of 179 imported cases were reported in Guangdong by April 10th, 2020. The average interval
between entry of mainland China and diagnosis was 4.21 days with a median of 2 days. The interval was between 1 and 3 days in 69.8% of the cases. Multivariate logistic regression analysis showed that a negative result of the initial nucleic acid test (OR=5.205,
95% CI: 1.100-24.640, P=0.038) and interval between entry of mainland China and a positive diagnosis >2 days (OR=85.654, 95% CI: 24.569-298.615, P < 0.001) were risk factors for the finding delay. The results of initial nucleic acid detection and the interval
between entry of mainland China and a positive diagnosis of COVID-19 are the major contributing factors of delayed case detection. |
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Chhetri, Bishal, Bhagat, et al |
arXiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The present work deals with optimal drug regimen and the efficacy of combined therapy in treatment of COVID-19. The
drug interventions considered include Arbidol, Remdesivir, Interferon and Lopinavir/Ritonavir. The basic reproduction number and viral count decreased the best when all the four interventions were applied together reinstating the fact obtained earlier in the
optimal control setting. |
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Chi, X, Liu, et al |
Nature communications |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, using SARS-CoV-2 spike receptor-binding domain (RBD) as a bait, we generate a panel of humanized single domain
antibodies (sdAbs) from a synthetic library. These sdAbs reveal binding kinetics with the equilibrium dissociation constant (KD) of 0.99-35.5 nM. The monomeric sdAbs show half maximal neutralization concentration (EC50) of 0.0009-0.07 µg/mL and 0.13-0.51 µg/mL
against SARS-CoV-2 pseudotypes, and authentic SARS-CoV-2, respectively. Competitive ligand-binding experiments suggest that the sdAbs either completely block or significantly inhibit the association between SARS-CoV-2 RBD and viral entry receptor ACE2. Fusion
of the human IgG1 Fc to sdAbs improve their neutralization activity by up to ten times. These results support neutralizing sdAbs as a potential alternative for antiviral therapies. |
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Cho, Jungwoo, Shin, et al |
arXiv |
Public health interventions*| Interventions de santé publique |
In this paper, we employ a data-centric approach to investigate individual mobility adaptations and mask-wearing in
Seoul, South Korea. We first identify six epidemic phases and two waves based on COVID-19 case count and its geospatial dispersion. The phase-specific linear models reveal the strong, self-driven mobility reductions in the first escalation and peak with a
common focus on public transit use and less-essential weekend/afternoon trips. However, comparable reduction was not present in the second wave, as the shifted focus from mobility to mask-wearing was evident. Although no lockdowns and gentle nudge to wear
mask seemed counter-intuitive, simple and persistent communication on personal safety has been effective and sustainable to induce cooperative behavioral adaptations. Our phase-specific analyses and interpretation highlight the importance of targeted response
consistent with the fluctuating epidemic risk. |
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Choudhary, R, Kaushik, et al |
Cardiovascular Diagnosis and Therapy |
Healthcare Response | Réponse des soins de santé |
We report a case of 64-year-old male, who was taken for urgent coronary angiogram (CAG) in view of non ST elevation
acute coronary syndrome. Despite all efforts, patient could not be saved as he didn’t receive timely intervention. Increased travel time to emergency department due to lockdown because of COVID-19 and along with extra time required for donning of personal
protection equipment (PPE) and other COVID-19 related safety measures prolonged the ischemic time. |
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Students
feedback on the forced transition to online classroom during Covid-19 |
Chuenwatanakul, P, Khamkanya, et al |
|
Public Health response| Interventions de santé publique |
This study presents the survey of students' reaction to online classrooms and the adaptability to the online classroom
of both students and instructors from the department of industrial engineering, Thammasat University. Students' feedback was collected after the first week of online classroom. The result shows that, in the beginning, there were several problems reported from
students, such as the confusion of different platforms used among all courses, sense of isolation, lack of equipment of students, and limited skills of using the online teaching platform of instructors. The most recommended online classroom platforms by students
are Zoom for online meetings and Microsoft Teams for learning management systems. It seems that the most concern for students is lacking peer interaction and the learning atmosphere as provided in the traditional classroom. |
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Cohen, G, Russo, et al |
Frontiers in Psychiatry |
Public Health response| Interventions de santé publique |
Our objective was to study to what extent mandatory quarantine imposed due to COVID-19 in Argentina had affected behavioral
symptoms in subjects with dementia after the first 8 weeks of quarantine. Important findings were increased anxiety, insomnia, depression, worsening gait disturbance, and increase use of psychotropics to control behavioral symptoms. Anxiety, depression, and
insomnia were more prevalent in subjects with mild dementia compared to subjects with severe dementia. Rehabilitation services had been discontinued in most subjects due to the quarantine. |
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Collange, O, Tacquard, et al |
Open Forum Infectious Diseases |
Clinical data| Données cliniques |
A 56-year-old man presented a particularly severe and multisystemic case of coronavirus disease 2019 (COVID-19). In
addition to the common lung and quite common pulmonary embolism and kidney injuries, he presented ocular and intestinal injuries that, to our knowledge, have not been described in COVID-19 patients. Although it is difficult to make pathophysiological hypotheses
about a single case, the multiplicity of injured organs argues for a systemic response to pulmonary infection. |
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Consonni, D, Bordini, et al |
Acta bio-medica : Atenei Parmensis |
Epidemiology| Épidémiologie |
The paper presents the data of infection of healthcare workers of a research and teaching hospital in Milan, Italy.
The majority (2554, 55.9%) of 4572 HCWs were tested for SARS-CoV-2 and 8.8% were found positive. The higher frequency of positive tests in the medicine area is probably explained by the higher concentration in that area of COVID-19 patients. Conversely, the
low frequency of positive HCWs in intensive care units is probably explained by the diffuse and continuous use of PPD. |
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Contreras-Puentes, N, Alvíz-Amador, et al |
Biomedical and Pharmacology Journal |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In order to search for alternatives to counteract the virus, computational screening tools have been used, employing
molecular docking methodologies through natural ligands, drugs and analogues against SARS-CoV-2 proteases. saikosponin D, amentoflavone, theaflavin, glycyrrhizin, SCHEMBL3057328, ledipasvir, MK- 3207 and paratiprevir, demonstrated the best binding energies
and interactions with binding sites. |
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Corcorran, MA, Olin, et al |
American Journal of Infection Control |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We describe key characteristics, interventions, and outcomes of a SARS-CoV-2 outbreak within an inpatient geriatric
psychiatry unit at the University of Washington Medical Center – Northwest. Asymptomatic infection was common in this cohort of hospitalized (30%), elderly individuals despite similar duration of SARS-CoV-2 RT-PCR positivity (viral RNA shedding) and cycle
threshold values among symptomatic and asymptomatic patients. |
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Corrêa, DG, de Souza Lima, et al |
Multiple Sclerosis Journal |
Clinical data| Données cliniques |
We present a case of COVID-19-related encephalomyeloradiculitis with clinical and magnetic resonance imaging characteristics
of neuromyelitis optica spectrum disorders that was associated with anti-aquaporin-4 antibodies. Our case suggests post-infectious autoimmunity as a mechanism in at least a subset of patients with COVID-19-related neurologic disease. |
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Crameri, GAG, Bielecki, et al |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In March 2020, we observed an outbreak of COVID-19 among a relatively homogenous group of 199 young (median age 21
years; 87% men) Swiss recruits. By comparing physical endurance before and in median 45 days after the outbreak, we found a significant decrease in predicted maximal aerobic capacity in COVID-19 convalescent but not in asymptomatically infected and SARS-CoV-2
naive recruits. This finding might be indicative of lung injury after apparently mild COVID-19 in young adults. |
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Description of 12 HIV-positive patients who have had the COVID-19 in our area |
Cucurull-Canosa, J, Vega-Molpeceres, et al |
Enfermedades infecciosas y microbiologia clinica |
Clinical data| Données cliniques |
We have diagnosed 317 cases of COVID-19 confirmed by RT-PCR in our area, 12 of them were HIV-positive. Hospital admission
was indicated in 7 patients and in the remaining 5, telephone follow-up without admission was carried out. All hospitalized patients were treated with the combination of hydroxychloroquine (HCQ) and azithromycin, 6 patients including the 5 who had pneumonia
also received corticosteroids in different doses. Low molecular weight heparin was administered in a prophylactic dose to all of them. Patients who were not admitted were only prescribed symptomatic treatment if necessary. Three of the 12 patients died. |
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Acute myocarditis as the main clinical manifestation of SARS-CoV 2 infection: A case
report |
Cuomo, G, Menozzi, et al |
Infectious Disease Reports |
Clinical data| Données cliniques |
We describe a case of acute myocarditis which was reported as the main COVID-19 clinical manifestation, with a favorable
outcome. In addition to symptoms, laboratory tests (BNP and troponin), echocardiogram and cardiac MRI contributed to diagnosis. Regardless heart biopsy was not obtained, it is likely an immunological pathogenesis of this condition which pave the way to further
therapeutic implications, since there are currently no standardized treatments. |
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Cuschieri, S, Calleja Agius, et al |
Anat Sci Educ |
Public Health response| Interventions de santé publique |
The aim of this study was to evaluate the student's perspectives and experiences on the shift to remote preclinical
medical education due to COVID-19 while enquiring whether there has been any psychological impact on the students. Less than half the students exhibited symptoms of anxiety. Students exhibiting "moderate" worry and "severe" worry on their mental, emotional
and wellbeing due to COVID-19 were associated with anxiety symptoms after adjusting for cofounders. |
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Czerwińska, E, Szenborn, et al |
Pediatria polska |
Public health interventions*| Interventions de santé publique |
This study examined how these lockdown measures due to COVID-19 changed the incidence of other infectious diseases.
The incidence of common and serious infectious diseases in the period 1.01.2020 to 15.05.2020 was evaluated and compared to the corresponding period from the year 2019. A significant drop in the number of reported infectious diseases can be seen in the middle
and at the end of March. These observations correlate with the time of introducing social distancing in Poland. |
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Da Cunha de Sá-Caputo, D, Sonza, et al |
Acta bio-medica : Atenei Parmensis |
Public Health response| Interventions de santé publique |
The aim of this study was to develop, validate and perform the reliability of the questionnaire "Physical exercise
(PE) level before and during social isolation (PEF-COVID19)" to evaluate the level of PE during the social distancing due to the COVID-19 pandemic and to try to identify changes in the daily life of the individuals. This survey was considered valid and reliable
to be applied to the general population over 18 years-old. |
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Dabas, V, Bhatia, et al |
Indian Journal of Orthopaedics |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
We present our experience in managing the patients at Government-run non-COVID-19 trauma center in Delhi in an algorithmic
form. We describe the inflow, in-hospital management and outflow of patients at our facility during the lockdown period and in the following unlock period (from 23 March to 8 July 2020). We also highlight the changes incorporated in OT settings as well as
in rehabilitative and follow-up period. Following the described protocol helped us maintain a balance between the safety of patients and our front line workers which was evident by very low COVID-19-positive rate in admitted patients (4.22%) and health care
providers (16.67%) in the above-mentioned time period. |
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Darling-Hammond, S, Michaels, et al |
Health Education and Behavior |
Public Health response| Interventions de santé publique |
On March 8, 2020, there was a 650% increase in Twitter retweets using the term “Chinese virus” and related terms. On
March 9, there was an 800% increase in the use of these terms in conservative news media articles. Using data from non-Asian respondents of the Project Implicit “Asian Implicit Association Test” from 2007–2020 (n = 339,063), we sought to ascertain if this
change in media tone increased bias against Asian Americans. This research provides evidence that the use of stigmatizing language increased subconscious beliefs that Asian Americans are “perpetual foreigners.” |
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Das, JP, Yeh, et al |
Eur J Nucl Med Mol Imaging |
Clinical data| Données cliniques |
We reviewed the clinical utility of perfusion (Q)-single-photon emission computed tomography (SPECT)/CT for diagnosing
pulmonary embolus (PE) in patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Of the 33 patients imaged with Q-SPECT/CT, 6 patients (3 men, 3 women) had a laboratory confirmed diagnosis of COVID-19. Q-SPECT/CT was positive
in 4/6 (67%) of patients. Distribution of pulmonary emboli was bilateral and segmental in 75% of patients. |
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Sensitive Detection and Quantification of SARS-CoV-2 by Multiplex Droplet
Digital RT-PCR |
De Kock, Remco, Baselmans, et al |
Research Square prepub |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We aimed to develop a one-step droplet digital RT-PCR (RT-ddPCR) multiplex assay that allows for sensitive detection
of SARS-CoV-2 RNA with respect to human derived RNA. Assay sensitivity of the RT-PCR assay drastically decreased when SARS-CoV-2 copies were detected in a background of total NA extract compared to water, while the sensitivity of the RT-ddPCR was not affected
by the total NA background. The present study describes a robust and sensitive one-step RT-ddPCR multiplex assay for reliable detection and quantification of SARS-CoV-2 RNA. |
|
De Vente, Coen, Boulogne, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This paper identifies a variety of components that increase the performance of convolutional neural networks (CNN)-based
algorithms for COVID-19 grading from CT images. A 3D CNN achieved an area under the ROC curve (AUC) of 0.934 on our test set of 105 CT scans and an AUC of 0.923 on a publicly available set of 742 CT scans, a substantial improvement in comparison with a previously
published 2D CNN. |
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De, P, Bhayye, et al |
J Biomol Struct Dyn |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study aims at developing a quantitative structure-activity relationship (QSAR) model against a group of 3CL(pro)
inhibitors to study their structural requirements for their inhibitory activity. Further, molecular docking studies were carried out which helped in the justification of the QSAR findings. Moreover, molecular dynamics simulation study was performed for selected
compounds to check the stability of interactions as suggested by the docking analysis. The current QSAR model was further used in the prediction and screening of large databases within a short time. |
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Decavele, M, Trosini-Désert, et al |
Crit Care |
Clinical data| Données cliniques |
Here, we describe the feasibility, safety, and diagnostic accuracy of endobronchial ultrasound (EBUS) to detect pulmonary
embolism (PE) in patients with severe SARS-CoV-2 ARDS requiring vv-ECMO. Between April 15 and May 1, 2020, eleven patients were included. This case series suggests that the EBUS procedure is safe and reliable to detect lobar and even segmental PE at bedside. |
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Dell'Utri, C, Manzoni, et al |
European Journal of Obstetrics and Gynecology and Reproductive Biology |
Healthcare Response | Réponse des soins de santé |
We have investigated the changes in the emergency flow occurred during SARS-CoV-2 pandemic in an obstetrics and gynecological
emergency services (ES) and the short-term adverse outcomes on women's and reproductive health. During the period February 24 - May 31, 2020 the admissions at the ES decreased by 35.4 % (95 % CI—34.1–36.6) compared with the corresponding period in 2019. In
the index period, five fetal deaths were diagnosed compared with one observed in the reference period in 2019 . The frequency of admission for elective caesarean section/labor induction increased from 47.5 % in 2019 to 53.6 % in 2020: this difference was statistically
significant. |
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Dey, Samarajit |
Research Square prepub |
Epidemiology| Épidémiologie Immunology | Immunologie |
Two seropravelence studies were undertaken in Delhi to test for SARS-CoV-2 antibodies. The survey conducted June 26-July
10 (sample size 21387) showed 23.48% seroprevalence, which was 79-times higher than corresponding virus-tested positives. Survey conducted August 1-7 (15311 samples) showed 29.1% antibody-positive, and was 44x of virus-tested positive total. This study seeks
to examine why the multiple should decline so drastically in one month, from 79x to 44x. The study indicates that there is a significant proportion of pre-existing cross-reactive antibodies (possibly to the HCoV viruses), that are seropositive in SARS-CoV-2
antibody tests, to the extent of 16%-19% of the population. |
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COVID-19 Mortality Rate Prediction for India Using Statistical Neural Network Models |
Dhamodharavadhani, S, Rathipriya, et al |
Frontiers in Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The primary aim of this study is to investigate suitable Statistical Neural Network (SNN) models and their hybrid version
for COVID-19 mortality prediction in Indian populations and is to estimate the future COVID-19 death cases for India. SNN models such as Probabilistic Neural Network (PNN), Radial Basis Function Neural Network (RBFNN), and Generalized Regression Neural Network
(GRNN) are applied to develop the COVID-19 Mortality Rate Prediction (MRP) model for India. The results showed that the PNN and RBFNN-based MRP model performed better than the other models. |
|
Díez Redondo, P, Núñez Rodríguez Mª, et al |
Rev Esp Enferm Dig |
Healthcare Response | Réponse des soins de santé |
Before resuming endoscopic activity, we designed a protocol to evaluate gastroscopies and colonoscopies cancelled during
the pandemic, denying inappropriate requests and prioritizing appropriate ones. Two types of inappropriate request were established: a) COVID-19 context, people aged ≤ 50 years without alarm symptoms and a low probability of relevant endoscopic findings;
and b) inappropriate context, requests not in line with clinical guidelines or protocols. Between March 16th and June 30th 2020, 1,658 requests were evaluated, of which 70 % were considered as appropriate and 30 % as inappropriate (20 % COVID-19 context, 80
% inappropriate context). |
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Common genetic variation in humans impacts in vitro
susceptibility to SARS-CoV-2 infection |
Dobrindt, Kristina, Hoagland, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We hypothesize that, in addition to viral load and host antibody repertoire, host genetic variants also impact vulnerability
to infection. Here we apply human induced pluripotent stem cell (hiPSC)-based models and CRISPR-engineering to explore the host genetics of SARS-CoV-2. We demonstrate that a single nucleotide polymorphism (rs4702), common in the population at large, impacts
alveolar and neuron infection by SARS-CoV-2 in vitro. |
|
Dobrzański, LA, Dobrzański, et al |
Processes |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
Dentists belong to the highest risk group for SARS-CoV-2 because the doctor works in the patient's respiratory tract.
This paper presents a breakthrough authors solution, implemented by the active SPEC strategy, and aims to eliminate clinical aerosol at the source by negative pressure aspirating bioaerosol at the patient's mouth line. The comparative benchmarking analysis
and its results show that only the proprietary solution with a set of devices eliminates the threat at the source, while the remaining known methods do not meet the expectations. |
|
|
Doi, Y, Hibino, et al |
Antimicrob Agents Chemother |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
We conducted a prospective, randomized, open-label, multicenter trial of favipiravir for the treatment of COVID-19
at 25 hospitals across Japan. Favipiravir did not significantly improve viral clearance as measured by RT-PCR by day 6 but was associated with numerical reduction in time to defervescence. Neither disease progression nor death occurred to any of the patients
in either treatment group during the 28-day participation |
|
|
Dolan, MaryE, Hill, et al |
bioRxiv |
Clinical data| Données cliniques Coronavirology| Coronavirologie Animal model | Modèle
animal |
COVID-19 presents more seriously in conjunction with other human disease conditions such as hypertension, diabetes,
and lung diseases. We conducted a bioinformatics analysis of COVID-19 comorbidity-associated gene sets, identifying genes and pathways shared among the comorbidities. Phenotypic analysis of shared genes revealed significant enrichment for immune system phenotypes
and for cardiovascular-related phenotypes, which might point to alleles and phenotypes in mouse models that could be evaluated for clues to COVID-19 severity. Through pathway analysis, we identified enriched pathways shared by comorbidity datasets and datasets
associated with SARS-CoV-2 infection. |
|
|
Dräger, S, Kather, et al |
Zeitschrift fur Allgemeinmedizin |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this work is to analyse the clinical characteristics of patients tested for SARS-CoV-2 at the Carl Gustav
Carus University Hospital in Dresden. In the study period from March 9 to March 31, 2020 2,257 patients were tested for SARS-CoV-2. 163 tests were positive. Main symptoms of SARS-CoV-2 infected patients are cough and headache. Muscle pain, headache and fever
were significantly more common in people infected with SARS-CoV-2. Patients often present just before or during the critical phase of the disease. |
|
|
Du, H, Pan, et al |
Respir Res |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Our aim of this retrospective cohort study was to investigate the association of severe COVID-19 illness with vascular
risk factor burden. Kaplan-Meier curves showed a gradual increase in the risk of severe COVID-19 illness stratified by the number of vascular risk factors. After adjustment for age, sex, and comorbidities as potential confounders, vascular risk factor burden
remained associated with an increasing risk of severe COVID-19 illness. |
|
|
Analysis of the influence of psychological contract on employee safety behaviors against
COVID-19 |
Du, Y, Liu, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
This study explored the influencing factors of safety behavior from the perspective of employees, studied the mechanism
of the psychological contract on employees’ safety behavior in the context of the Chinese epidemic situation, tested the mediating role of job burnout and perceived insider status in the process of work resumption, and provided preventive suggestions for combating
the global spread of COVID-19. The results show that employees’ conscious participation in safety behavior plays an irreplaceable role in the prevention of COVID-19 and safety of work resumption. |
|
Dudel, C, Riffe, et al |
PloS one |
Epidemiology| Épidémiologie |
We analyze the contribution of two key determinants of the variation in the observed case-fatality rate (CFR): the
age-structure of diagnosed infection cases and age-specific case-fatality rates. We use data on diagnosed COVID-19 cases and death counts attributable to COVID-19 by age for China, Germany, Italy, South Korea, Spain, the United States, and New York City. The
age-structure of detected cases often explains more than two-thirds of cross-country variation in the CFR. The importance of the age-structure of confirmed cases likely reflects several factors, including different testing regimes and differences in transmission
trajectories; while increasing age-specific case-fatality rates in Italy could indicate other factors, such as the worsening health outcomes of those infected with COVID-19. |
|
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COVID-19 pandemic trend modeling and analysis to support resilience decision-making |
Duffey, RB, Zio, et al |
Biology |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission |
In this paper, we provide a theoretical framework for the analysis and prediction of the infection rate evolution in
time due to the CoVid-19 spreading. By comparison with the theories of growth and recovery in coupled socio-medical systems, we find that the data for many countries show infection rate trends that are exponential in form. In particular, the recovery trajectory
is universal in trend and consistent with the learning theory, which allows for predictions useful in the assistance of decision-making of emergency recovery actions. |
|
Comparison of commercial assays and laboratory developed tests for detection
of SARS-CoV-2 |
Dust, K, Hedley, et al |
Journal of virological methods |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we compared the performance of two commercial assays, the cobas® SARS-CoV-2 (Roche Diagnostics) and Xpert® Xpress
SARS-CoV-2 (Cepheid®) tests, and a laboratory developed RT-PCR test adapted for use on the Hologic® Panther Fusion® (Hologic®) instrument as well as Bio-Rad and QIAGEN real-time PCR detection systems. Due to assay-specific differences in sample processing
and nucleic acid extraction, the overall analytical sensitivity ranged from 24 copies/mL specimen to 574 copies/mL specimen. Despite these differences, there was 100 % agreement between the commercial and laboratory developed tests. No false-negative or false-positive
SARS-CoV-2 results were observed and there was no cross-reactivity with common respiratory viruses, including endemic coronaviruses. |
|
Ehrhardt, J, Ekinci, et al |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
Epidemiology| Épidémiologie Transmission Public health interventions*| Interventions
de santé publique |
We investigated data from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected 0-19 year olds, who
attended schools/childcare facilities, to assess their role in SARS-CoV-2 transmission after these establishments' reopening in May 2020 in Baden-Württemberg, Germany. Child-to-child transmission in schools/childcare facilities appeared very uncommon. We anticipate
that, with face mask use and frequent ventilation of rooms, transmission rates in schools/childcare facilities would remain low in the next term, even if classes' group sizes were increased. |
|
|
Ehrman, RR, Brennan, et al |
Journal of Emergency Medicine |
Clinical data| Données cliniques |
We present 2 cases of patients with COVID-19 that presented with ST-elevation myocardial infarction (STEMI) on electrocardiogram.
While both patients underwent cardiac catheterization, a delay in time to intervention in the patient found to have acute coronary artery occlusion may have contributed to a poor outcome. |
|
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Telemedicine during COVID-19: a survey of Health Care Professionals' perceptions |
Elawady, A, Khalil, et al |
Monaldi Arch Chest Dis |
Healthcare Response | Réponse des soins de santé |
The National Health Service (NHS) has rapidly adopted telemedicine solutions as an alternative to face-to-face consultations
during the COVID-19 pandemic. Remote consultation is expected to continue for the foreseeable future, thus we designed this survey to evaluate the use of telephone consultation by healthcare providers, assessing its implementation, challenges and drawbacks.
The most common barrier in remote consultation was the inability to access patient records raised by 37% of respondents. However, 73% of respondents felt that patients understood their medical condition and the instructions given to them over the phone, and
70% agreed that videoconference consultations would add to patients care. |
|
Expectant management of pneumothorax in intubated COVID-19 positive patients: a
case series |
Elder, C, Bawa, et al |
J Cardiothorac Surg |
Clinical data| Données cliniques |
In this series we report four cases of patients with respiratory distress who tested positive for COVID-19 via nasopharyngeal
swab and developed ventilator-induced pneumothoraces which were successfully managed with observation alone. |
|
32921747; Intrauterine transmission of COVID-19 in pregnancy: Case report and review
of literature |
Elkafrawi, D, Joseph, et al |
Acta Biomedica |
Clinical data| Données cliniques |
Case report of a 34 year old pregnant female |
|
Elkahloun, AG, Saavedra, et al |
Biomedicine and Pharmacotherapy |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Angiotensin receptor blockers (ARBs) reducing inflammation and protecting lung and brain function, could be of therapeutic
efficacy in COVID-19 patients. Methods: Using GSEA, we compared our previous transcriptome analysis of neurons injured by glutamate and treated with the ARB Candesartan (GSE67036) with transcriptional signatures from SARS-CoV-2 infected primary human bronchial
epithelial cells (NHBE) and lung postmortem (GSE147507), PBMC and BALF samples (CRA002390) from COVID-19 patients. Results: Hundreds of genes upregulated in SARS-CoV-2/COVID-19 transcriptomes were similarly upregulated by glutamate and normalized by Candesartan.
Gene Ontology analysis revealed expression profiles with greatest significance and enrichment, including proinflammatory cytokine and chemokine activity, the NF-kappa B complex, alterations in innate and adaptive immunity, with many genes participating in
the COVID-19 cytokine storm. |
|
|
Elmore, JG, Wang, et al |
Journal of medical Internet research |
Surveillance |
The aim of this study is to investigate whether excess visits where the word "cough" was present in the EHR (USA) reason
for visit, and hospitalizations with acute respiratory failure were more frequent from December 2019 to February 2020 compared with the preceding 5 years. The percentage of patients presenting with an EHR reason for visit containing the word "cough" to clinics
exceeded the 95% prediction interval the week of December 22, 2019, and was consistently above the 95% prediction interval all 10 weeks through the end of February 2020. Similar trends were noted for emergency department visits and hospitalizations starting
December 22, 2019, where observed data exceeded the 95% prediction interval in 6 and 7 of the 10 weeks, respectively. The estimated excess over the 3-month 2019/2020 winter season, obtained by either subtracting the maximum or subtracting the average of the
five previous seasons from the current season, was 1.6 or 2.0 excess visits for cough per 1000 outpatient visits, 11.0 or 19.2 excess visits for cough per 1000 emergency department visits, and 21.4 or 39.1 excess visits per 1000 hospitalizations with acute
respiratory failure, respectively. A significantly higher number of patients with respiratory complaints and diseases starting in late December 2019 and continuing through February 2020 suggests community spread of SARS-CoV-2 prior to established clinical
awareness and testing capabilities. |
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|
Embregts, Pjcm, Tournier, et al |
J Appl Res Intellect Disabil |
Healthcare Response | Réponse des soins de santé |
Qualitative study, the experiences and needs of direct support staff during the COVID‐19 pandemic, which, in turn,
can help inform practice in preparation for a second wave of COVID‐19 or another future pandemic. Four themes emerged: (1) Emotional impact, which pertained to various emotions they experienced in their work; (2) Cognitive impact, which referred to challenges
and changes they had undergone in their work; (3) Practical impact, which centred on the practical impact of the pandemic on their work; and (4) Professional impact, which concerned their experiences with other professionals. |
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SARS-CoV-2 host receptors ACE2 and CD147 (BSG) are present on human oocytes and
blastocysts |
Essahib, W, Verheyen, et al |
J Assist Reprod Genet |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
To visualize SARS-CoV-2 host receptors ACE2 and CD147 on human oocytes and blastocysts. SARS-CoV-2 host receptors ACE2
and CD147 are present on the membrane of trophectoderm, epiblast and hypoblast cells in human blastocysts. CD147 is also present on the oolemma. heoretically, the earliest stages of embryonic development may be vulnerable for SARS-CoV-2 infection. |
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32909713; Unexplained Methemoglobinemia in Coronavirus Disease 2019: A Case Report |
Faisal, H, Bloom, et al |
A&A practice |
Clinical data| Données cliniques |
Case report: We report the successful management of a case of refractory hypoxia due to acutely acquired methemoglobinemia
in a patient undergoing treatment for coronavirus disease 2019 (COVID-19) pneumonia. The cause of methemoglobinemia in this patient remains unknown. Hypoxia and methemoglobinemia did not respond to methylene blue and required administration of packed red blood
cell transfusions. |
|
Farrell, AM, Walsh, et al |
Irish medical journal |
Clinical data| Données cliniques |
increase in venous thromboembolism (VTE) events in patients with COVID-19. Sixty-one patients were identified. Twelve
patients (19.6%) admitted with COVID-19 were treated for a suspected PE. Of these patients, 3 patients were discharged on anticoagulation, 3 died and 6 remain inpatients at the end of the study period. |
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Fernandes, José Sebastião Cunha, Silva, et al |
Research Square prepub |
Epidemiology| Épidémiologie |
Brazilian cities at lower altitudes and greater air relative humidity have higher relative incidence and relative deaths
from COVID-19. Our epidemiological analysis found that the relative incidence (RI) and relative death rate (RDR) and between air relative humidity (RH) were higher in cities located in low (0 to 97 m a.s.l) compared to medium (98 to 790 m a.s.l) and high (791
to 1135 m a.s.l) cities altitudes. Furthermore, it has been shown that there is a negative correlation between the incidence of COVID-19 with altitude and a positive correlation with air relative humidity in the cities analysed. |
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Fernández-Aranda, F, Munguía, et al |
Eur Eat Disord Rev |
Healthcare Response | Réponse des soins de santé |
Confinement during the COVID-19 pandemic is expected to have a serious and complex impact on the mental health of patients
with an eating disorder (ED) and of patients with obesity. (1) to analyse the psychometric properties of the COVID Isolation Eating Scale (CIES), (2) to explore changes that occurred due to confinement in eating symptomatology; and (3) to explore the general
acceptation of the use of telemedicine during confinement. Regarding the effects of confinement, positive and negative impacts of the confinement depends of the eating disorder subtype. Patients with anorexia nervosa (AN) and with obesity endorsed a positive
response to treatment during confinement, no significant changes were found in bulimia nervosa (BN) patients, whereas Other Specified Feeding or Eating Disorder (OSFED) patients endorsed an increase in eating symptomatology and in psychopathology |
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|
Ferrari, D, Cabitza, et al |
Acta bio-medica : Atenei Parmensis |
Surveillance |
Italy: High LDH and AST levels' variations induced by COVID-19, routine blood tests might be exploited as a surveillance
indicator for a possible second wave. We retrospectively analyzed the AST and LDH levels from more than 30.000 patients admitted to the San Raffaele Hospital Emergency Room (ER) between September 2019 and May 2020 as well as between September 2018 and May
2019. Data showed that the ER averaged AST and LDH levels are highly sensitive to the presence of COVID-19 patients. |
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|
Ferrari, D, Sabetta, et al |
Acta bio-medica : Atenei Parmensis |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The study represents a preliminary work aiming at the development of strategies that, by combining RT-PCR tests with
routine blood tests, will lower or even abolish the rate of RT-PCR false-negative results and thus will identify, with high accuracy, patients infected by COVID-19. We retrospectively analyzed 24 patients showing multiple and inconsistent RT-PCR, test during
their first hospitalization period, and compared the genetic tests results with their AST and LDH levels. We showed that when considering the hematological parameters, the RT-PCR false-negative rates were reduced by almost 4-fold. |
|
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A sharp drop in psychiatric emergency admissions during lockdown |
Flevaud, L, Pham, et al |
Annales Medico-Psychologiques |
Healthcare Response | Réponse des soins de santé |
In French: Since France was put into lockdown on 17 March 2020 in an unprecedented step to attempt to limit the spread
of coronavirus, there has been a sharp fall in the number of psychiatric emergency admissions despite the COVID-19 pandemic which has increased stress levels. The first part of this study shows the reorganisation and adaptation of mental health services to
meet the needs in the psychiatric department. The second part is a brief analysis of patient flows to CPOA and the presentation of different hypotheses explaining these disruptions during lockdown. Finally, this study discusses the facts of three clinical
cases during this period. |
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Increased in-hospital mortality from COVID-19 in patients with schizophrenia |
Fond, G, Pauly, et al |
Encephale |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to compare the clinical characteristics and outcomes of COVID-19 schizophrenia (SCZ) patients with those
of non-SCZ patients, Marseille, southern France. This study suggests that SCZ is not overrepresented among COVID-19 hospitalized patients, but SCZ is associated with excess COVID-19 mortality, confirming the existence of health disparities described in other
somatic diseases. A total of 1092 patients were included. The overall in-hospital mortality rate was 9.0%. The SCZ patients had an increased mortality compared to the non-SCZ patients (26.7% vs. 8.7%, P = 0.039), which was confirmed by the multivariable analysis
after adjustment for age, sex, smoking status, obesity and comorbidity (adjusted odds ratio 4.36 95% CI: 1.09–17.44]; P = 0.038). In contrast, the SCZ patients were not more frequently admitted to the ICU than the non-SCZ patients. Importantly, the SCZ patients
were mostly institutionalized (63.6%, 100% of those who died), and they were more likely to have cancers and respiratory comorbidities. |
|
Galedar, N, Toulabi, et al |
Nursing Open |
Healthcare Response | Réponse des soins de santé |
Qualitative study of nurses at Lorestan University of Medical Sciences: Qualitative analysis of the data revealed
3 sub-categories, 8 categories and 3 main categories including care erosion, nursing professional growth and necessities. Relevance to clinical practice: Improve the work situation of the nurses during care of COVID-19 patients, which can directly or indirectly
improve the quality of care of these patients. |
|
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Atypical presentation of COVID-19 in hospitalised older adults |
Gan, JM, Kho, et al |
Ir J Med Sci |
Clinical data| Données cliniques |
A retrospective analysis of adults ≥ 65 years with confirmed COVID-19 admitted to our institution between 1 March and
24 April 2020 was performed. In the atypical group, common presenting complaints were fall in 18 (36%), reduced mobility or generalized weakness in 18 (36%) and delirium in 11 (22%). Further assessment by paramedics and on admission found 32 (65%) to have
typical features of COVID-19, fever being the most common, and 22 (44%) were hypoxic. This subset had worse outcomes than those in the typical group with a mortality rate of 50% versus 38%, respectively, although this was not statistically significant (P =
0.27). No significant difference in mortality or length of hospital stay between the groups was demonstrated. |
|
Impact of covid 19 on the mental health and qulaity of sleep among health care
professionals |
Ganapathy Sankar, U, Monisha, et al |
International Journal of Pharmaceutical Research |
Healthcare Response | Réponse des soins de santé |
India: We aim to evaluate and to correlate the anxiety, depression and sleep among healthcare professionals. Low
level of anxiety and minimal depression. There is no statistical significant correlation between anxiety and sleep, sleep and anxiety and depression & depression and depression and sleep at 95% (p>0.05). |
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Early Indicators of COVID-19 Spread Risk Using Digital Trace Data of Population Activities |
Gao, Xinyu, Fan, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Early Indicators of COVID-19 spread: The objective of this paper is to specify and examine early indicators of disease
spread risk in cities during the initial stages of outbreak based on patterns of human activities obtained from digital trace data. The results show statistically significant correlations between the indicators of human activities and the basic reproduction
number in all counties, as well as a significant leader-follower relationship (time lag) between them. The results also show one to two weeks' lag between the change in activity indicators and the decrease in the basic reproduction number. This result implies
that the human activity indicators provide effective early indicators for the spread risk of the pandemic during the early stages of the outbreak. |
|
Risk of metformin in type 2 diabetes patients with COVID-19: a preliminary retrospective
report |
Gao, Y, Liu, et al |
Clin Transl Sci |
Clinical data| Données cliniques |
We propose that metformin withdrawal in COVID-19 patients be considered to prevent disease progression. We enrolled
110 hospitalized COVID‐19 patients with diabetes under either metformin or non‐metformin hypoglycemic treatment for a case‐control study. There were no differences between the two groups in age, gender, comorbidities, and clinical severity at admission. Strikingly,
the percentage of cases who experienced life-threatening complications was significantly higher in the metformin group (28.6% (16/56) versus 7.4% (4/54), P = 0.004). Antidiabetic therapy with metformin was associated with a higher risk of disease progression
in COVID-19 patients with diabetes during hospitalization (adjusted odds ratio = 3.964, 95%CI 1.034-15.194, P = 0.045). This retrospective analysis suggested a potential safety signal for metformin, the use of which was associated with a higher risk of severe
COVID-19. |
|
COVID-19 and the problem
of the times in the control strategies |
Garcell, HG, Valdés, et al |
Revista Habanera de Ciencias Medicas |
Clinical data| Données cliniques |
In Spanish: case report of a case that tested negative on presentation and eventually tested positive. |
|
Garnero, M, Del Sette, et al |
Journal of the neurological sciences |
Healthcare Response | Réponse des soins de santé |
Retrospective evaluation of the Guillan-Barré Syndrome case during peak pandemic. Fifteen GBS patients were admitted
to the Hospitals of Liguria, from February 15th to May 3rd 2020, six with SARS-CoV-2 infection and nine without infection. Multi-organ involvement, delay in the diagnosis, incomplete work up and start of therapy, were registered in 50% of cases with a GBS-Disability
scale ≥4 at follow-up evaluation. In not-COVID-19 related GBS, main problem was diagnostic delay. In three patients the first neurological observation took place after a mean of 33,6 days. Moreover, five patients went to emergency room after an average of
30 days since the onset of neurological symptoms because of fear of contagion |
|
|
COVID-19 in hematology: data from a hematologic and transplant unit |
Garnica, M, Valetim, et al |
Hematology, Transfusion and Cell Therapy |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Brazil: We addressed our preparation to face COVID-19 pandemic in a Hematological and Stem Cell Transplant Unit in
Brazil during the first two months of COVID-19 pandemic and described COVID-19 cases in patients and health care workers (HCW). We report 11 cases of COVID-19 in hematological patients (including 2 post stem cell transplant) and 28 cases in HCW. Hematological
cases were most severe or moderate and presented with several poor risk factors. Among HCW, COVID-19 were mostly mild, and all recovered without hospitalization. |
|
Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation |
Gendrot, M, Andreani, et al |
Travel Medicine and Infectious Disease |
Therapeutics| Thérapeutique |
We investigated the in vitro antiviral activity against SARS-CoV-2 of several antimalarial drugs. Based on our results,
we would expect that countries which commonly use artesunate-amodiaquine or artesunate-mefloquine report fewer cases and deaths than those using artemether-lumefantrine or dihydroartemisinin-piperaquine. |
|
Gentry, ChrisA, Humphrey, et al |
The Lancet Rheumatology |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Hydroxychloroquine is one of several agents being evaluated in the treatment of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection. March 1 and June 30, 2020. The incidence of active SARS-CoV-2 infections during the study period did not differ between patients receiving hydroxychloroquine and patients not receiving hydroxychloroquine (31 [0·3%] of 10 703 vs 78
[0·4%] of 21 406; odds ratio 0·79, 95% CI 0·52–1·20, p=0·27). In multivariate logistic regression analysis, receipt of hydroxychloroquine was not associated with the development of active SARS-CoV-2 infection (odds ratio 0·79, 95% CI 0·51–1·42). There were
no significant differences in secondary outcomes between the two groups in patients who developed active SARS-CoV-2 infection. For all patients in the study, overall mortality was lower in the hydroxychloroquine group than in the group of patients who did
not receive hydroxychloroquine (odds ratio 0·70, 95% CI 0·55–0·89, p=0·0031). |
|
|
Giebel, C, Cannon, et al |
Aging Ment Health |
Public Health response| Interventions de santé publique |
PLWD and carers need to receive specific practical and psychological support during the pandemic to support their well-being,
which is severely affected by public health restrictions. 50 semi-structured interviews were conducted with unpaid carers (n = 42) and PLWD (n = 8). There was a significant reduction in social support service usage since the outbreak. Thematic analysis identified
three overarching themes: (1) Loss of control; (2) Uncertainty; (3) Adapting and having to adapt to the new normal. |
|
|
Diagnostic
yield of point-of-care ultrasound imaging of the lung in patients with COVID-19 |
Gil-Rodrigo, A, Llorens, et al |
Emergencias |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Objective. To assess the diagnostic yield of point-of-care ultrasound imaging in patients suspected of having noncritical
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection but no apparent changes on a chest radiograph. Methods. Cross-sectional analysis of a case series including patients coming to an emergency department in March and April 2020 with mild-moderate
respiratory symptoms suspected to be caused by SARS-CoV-2. A point-of-care ultrasound examination of the lungs was performed on all participants as part of routine clinical care. Ultrasound findings were compared according to the results of SARS-CoV-2 test
results. Results. Ultrasound findings were consistent with interstitial pneumonia due to coronavirus disease 2019 (COVID-19) in 33 (56.9%). Most were in cases with test-confirmed COVID-19. The most common ultrasound findings in confirmed COVID-19 cases were
focal and confluent B-lines in the basal and posterior regions of the lung and associated pleural involvement. |
|
Disentangling the Impact of the COVID-19 Lockdowns on Urban NO2 From Natural Variability |
Goldberg, DL, Anenberg, et al |
Geophysical Research Letters |
Public health interventions*| Interventions de santé publique |
TROPOMI satellite data show substantial drops in nitrogen dioxide (NO2) during COVID-19 physical distancing. To attribute
NO2 changes to NOx emissions changes over short timescales, one must account for meteorology. We find that meteorological patterns were especially favorable for low NO2 in much of the United States in spring 2020, complicating comparisons with spring 2019.
Meteorological variations between years can cause column NO2 differences of ~15% over monthly timescales. After accounting for solar angle and meteorological considerations, we calculate that NO2 drops ranged between 9.2% and 43.4% among 20 cities in North
America, with a median of 21.6%. Of the studied cities, largest NO2 drops (>30%) were in San Jose, Los Angeles, and Toronto, and smallest drops (<12%) were in Miami, Minneapolis, and Dallas. These normalized NO2 changes can be used to highlight locations with
greater activity changes and better understand the sources contributing to adverse air quality in each city. |
|
Faith in Trump, Moral Foundations, and Social Distancing Defiance during the Coronavirus
Pandemic |
Graham, A, Cullen, et al |
Socius |
Public Health response| Interventions de santé publique |
. The authors explore the underlying causes for those who intend to defy these norms. Methods: Using national-level
data from a March 2020 survey of 989 Americans, the authors explore intentions to defy social distancing norms by testing an interactionist theory of foundation-based moral behavior in combination with faith in President Trump during the coronavirus pandemic.
Results: Low self-control is the strongest predictor of defiance intentions. Consistent with interactionist theory, defiance intentions are significantly higher for those holding specific faith in Trump and those endorsing binding foundations. |
|
Baseline T cell immune phenotypes predict virologic
and disease control upon SARS-CoV infection |
Graham, Jessica, Swarts, et al |
bioRxiv |
Immunology | Immunologie Animal model | Modèle animal |
Here, we utilized data from a screen of genetically diverse mice from the Collaborative Cross (CC) infected with SARS-CoV
to determine whether circulating baseline T cell signatures are associated with a lack of viral control and severe disease upon infection. SARS-CoV infection of CC mice results in a variety of viral load trajectories and disease outcomes. Further, early control
of virus in the lung correlates with an increased abundance of activated CD4 and CD8 T cells and regulatory T cells prior to infections across strains. A basal propensity of T cells to express IFNg and IL17 over TNFa also correlated with early viral control.
Overall, a dysregulated, pro-inflammatory signature of circulating T cells at baseline was associated with severe disease upon infection. |
|
Graupensperger, S, Benson, et al |
Journal of Adolescent Health |
Public Health response| Interventions de santé publique |
The present study examined how student-athletes’ mental health was associated with teammate social support, connectedness,
and changes to athletic identity from before to during COVID-19. Method: A sample of 234 student-athletes completed surveys before COVID-19 physical distancing (February 2020), with 135 (63% female) participating in a follow-up in the month following school
closures (April 2020). Path models estimated the effects of teammate social support and connectedness (during COVID-19), as well as changes in athletic identity on indices of mental health. Results: student-athletes who received more social support and reported
more connectedness with teammates reported less dissolution of their athletic identity and—in most models—reported better mental health and well-being. |
|
|
New strategy of home-based exercise during pandemic COVID-19 in breast cancer patients:
A case study |
Grazioli, E, Cerulli, et al |
Sustainability (Switzerland) |
Healthcare Response | Réponse des soins de santé |
This case study, developed during the pandemic period, aims to evaluate the effectiveness of a proposed home-based
combined training (CT) regimen, supervised through online lessons, in increasing QoL and fatigue in breast cancer patients undergoing adjuvant therapy. Additionally, we evaluated the effect of exercise on psychological and functional parameters. Methods: From
March to June 2020, using a smartphone with WhatsApp video-calling, the patient performed two lessons per week, lasting 60 min each, for a total of 32 sessions in 16 weeks. Results: Improvements were found in the emotional function of QoL and in all variables
of fatigue (physical fatigue 66% in patient A; 33% in patient B). |
|
Grewal, E, Sutarjono, et al |
BMJ case reports |
Clinical data| Données cliniques |
Case report of a 57 year old male unknowingly with COVID-19, who presented to the emergency department with tongue
swelling, shortness of breath and difficulty in speaking following 4 months taking benazepril, an ACE inhibitor. |
|
|
Grzybowski, JMV, Da Silva, et al |
Mathematical Problems in Engineering |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Healthcare
Response | Réponse des soins de santé |
The objective of this study is to present an epidemic model specially tailored for the study of the COVID-19 epidemics,
and the model is aimed at allowing the integrated study of epidemic control strategies and dimensioning of the required medical infrastructure. Along with the theoretical model, a case study with three prognostic scenarios is presented for the first wave of
the epidemic in the city of Manaus, the capital city of Amazonas state, Brazil. Although the temporary collapse of the medical infrastructure is hardly avoidable in the state-of-affairs at this time (April 2020), the results show that there are feasible control
strategies that could substantially reduce the overload within reasonable time. Furthermore, this study delivers and presents an intuitive, straightforward, free, and open-source online platform that allows the direct application of the model. |
|
|
Guarino, M, Cossiga, et al |
J Med Internet Res |
Healthcare Response | Réponse des soins de santé |
OBJECTIVE: The aim of this study was to analyze the benefits of using telemedicine services for patients with chronic
liver disease (CLD) at a tertiary care center in Italy during the COVID-19-mandated lockdown. METHODS: From March 9 to May 3, 2020, a prospective observational study was conducted in the Liver Unit of the University Hospital of Naples Federico II to evaluate
the impact of (1) a fully implemented telemedicine program, partially restructured in response to COVID-19 to include video consultations; (2) extended hours of operation for helpline services; and (3) smart-working from home to facilitate follow-up visits
for patients with CLD while adhering to social distancing regulations. RESULTS: During the lockdown in Italy, almost 400 visits were conducted using telemedicine; only patients requiring urgent care were admitted to a non-COVID-19 ward of our hospital. Telemedicine
services were implemented not only for follow-up visits but also to screen patients prior to hospital admission and to provide urgent evaluations during complications. |
|
|
Levels of anxiety and depression among emergency
physicians in madrid during the sars-cov-2 pandemic |
Guillén-Astete, C, Penedo-Alonso, et al |
Emergencias |
Healthcare Response | Réponse des soins de santé |
The current study was conducted in the Basque Autonomous Community in northern Spain. The authors analyzed stress,
anxiety, and depression with the arrival of the virus and the levels of symptoms according to age, comorbidity, and confinement. Levels of anxiety, stress, and depression were measured in a sample of 976 adults, using the DASS scale ( Depression Anxiety, and
Stress Scale). Although levels of symptoms were generally low at the start of the alert, younger individuals with chronic diseases reported more symptoms than the rest of the population. The study also detected higher levels of symptoms after the stay-at-home
order was issued. Such symptoms are predicted to increase as the confinement continues. The authors propose psychological interventions for prevention and treatment in order to mitigate the pandemic's psychological impacts. |
|
Guo, X, Jie, et al |
Open Forum Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Methods. The clinical features obtained from a cohort of 195 laboratory-confirmed, nasopharynx-sampled patients with
COVID-19 in Guangdong, China from January 13 to February 29, 2020 were enrolled to this study. The differences in clinical features among 4 groups (mild, moderate, severe, and critical) and between 2 groups (severe vs nonsevere) were compared using oneway
analysis of variance and Student's t test, respectively. esults. In addition to the previously described clinical illness severity-related factors, including older age, underlying diseases, higher level of C-reactive protein, D-dimer and aspartate aminotransferase,
longer fever days and higher maximum body temperature, larger number of white blood cells and neutrophils but relative less lymphocytes, and higher ratio of neutrophil to lymphocytes, we found that the initial viral load is an independent factor that accounts
for illness severity in COVID-19 patients. Conclusions. The initial viral load of severe acute respiratory syndrome coronavirus 2 is a novel virological predictor for illness severity of COVID-19. |
|
|
Educating and evaluating in times of coronavirus: The situation in Spain |
Gutierrez, EJD, Espinoza, et al |
Multidisciplinary Journal of Educational Research |
Public Health response| Interventions de santé publique |
3400 Spaniards answered a survey, whose answers were analyzed, following mainly quantitative techniques (descriptive
statistical analysis,) but also qualitative ones (content analysis.) Five fundamental ideas were identified from the results: (1) the digital divide adds to and amplifies the social divide, increasing inequality in times of crisis; (2) technologies, which
have been an essential ally during the crisis, are not an alternative to the face-to-face educational relationship, but are an increasingly enriching tool to support the teaching-learning process; (3) it is necessary to rethink the current encyclopedic curriculum
in order to discern what is dispensable from what is indispensable and to prioritize relevant content; (4) evaluation is not about grading, it is about understanding how the learning process has taken place in order to help each student to keep moving forward,
and (5) it is necessary to " look after people " and give priority to their overall well-being, so that " no one is left behind". |
|
Perspectives, Knowledge, and Fears of Cancer Patients About COVID-19 |
Guven, DC, Sahin, et al |
Frontiers in Oncology |
Public Health response| Interventions de santé publique |
we aimed to assess the perspectives and fears of cancer patients about COVID-19 with resources of COVID-19 knowledge
with a questionnaire. A total of 250 adult cancer patients applied to the outpatient chemotherapy unit of Hacettepe University Cancer Center between May 27, 2020, and June 9, 2020, invited to answer a questionnaire of 13 multiple-choice questions with a return
rate of 78%. ost patients acquired their knowledge about COVID-19 from television (91.9%). Social media were the second most common source of knowledge (43.8%) with a predilection in younger patients, nonsmokers, targeted therapy- or immunotherapy-treated
patients, and breast cancer patients. More than 90% of the patients had a moderate to severe degree of COVID-19 fear. In addition, 27.6% of patients had false knowledge of glove using as a protective measure for COVID-19. More than half of the patients had
another wrong knowledge as the need for the supplements for COVID-19 protection. A significant percentage of patients (84.7%) expected some level of disruption in oncological care with the expectation of a moderate-to-severe disruption was more common in the
advanced-stage patients. |
|
32900176; Pasient med alvorlig covid-19 behandlet med rekonvalesensplasma |
Hahn, M, Condori, et al |
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke |
Clinical data| Données cliniques |
Case report of a male in his 70s with severe COVID-19 on prolonged ventilation |
|
Håkansson, A, Jönsson, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
This study in top elite athletes aimed to study current perceived psychological influence from COVID-19 and symptoms
of depression, anxiety and changes in alcohol drinking, gambling behavior and problem gambling in the midst of the COVID-19 lockdown. This web survey included athletes in top leagues of soccer, ice hockey and handball in Sweden (N = 327, 62% men). A total
of 66% and 51% were worried about the future of their sport or about their own future in sports, respectively. Feeling worse psychologically during the pandemic was common; depression criteria were endorsed by 19% of women and three percent of men; anxiety
criteria by 20% of women and five percent of men. Reporting increased gambling during the pandemic was associated with gambling problem severity. Moderate-risk or problem gambling was seen in 10% of men and none of the women. |
|
|
Hand Sanitizer in a Pandemic: Wrong Formulations in the Wrong Hands |
Hakimi, AA, Armstrong, et al |
Journal of Emergency Medicine |
Public Health response| Interventions de santé publique |
Methods: The first 100 videos on YouTube with the most views using the search term “DIY hand sanitizer” were evaluated
for accuracy compared with the World Health Organization local hand sanitizer production guidelines. The incidence of pediatric hand sanitizer exposure reported to participating U.S. poison control centers from January 2018 through May 2020 was reviewed from
the American Association of Poison Control Centers National Poison Data System. The average number of calls between January 2020 and May 2020 was compared, and the average number of calls in March 2020 was compared with March 2019 and March 2018. Results:
There was a significantly increased average number of daily calls to poison control centers regarding unsafe pediatric hand sanitizer exposure since the first confirmed COVID-19 patient in the United States. |
|
Role of
Vitamin D in Pathogenesis and Severity of Coronavirus Disease 2019 (COVID-19) Infection |
Hamza, A, Ahmed, et al |
Pakistan Journal of Medical and Health Sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Aim: To determine the vitamin D deficiency in COVID-19 infection and its association with the severity and fatality
of COVID-19 disease. Study Design: Descriptive cross sectional study Place and duration of study: Department of Internal Medicine Bolan Medical College Hospital Quetta from 1st March to 30th April 2020. Methods: A total of 168 patients diagnosed with COVID-19
infection, age ranged from 30 to 80 years of either gender were included. The brief medical history was taken and clinical examination were done. Nasopharyngeal and oropharyngeal swabs samples of patient for severe acute respiratory syndrome coronavirus 2
were collected and sent to the hospital medical laboratory to detect COVID-19 infection by using real-time polymerase chain reaction(RT-PCR). Blood sample of each patient were also collected to detect the vitamin D3 levels. Results: Vit D deficiency was significantly
associated with both asymptomatic and symptomatic cases. |
|
Haq, SU, Shahbaz, et al |
Journal of infection in developing countries |
Public Health response| Interventions de santé publique |
This study analyzed the knowledge, behavior, and precautionary measures taken by the general public to protect themselves
from COVID-19 pandemic. METHODOLOGY: For this purpose, snowball sampling technique was used to collect data from 401 respondents through an online survey in the Punjab province of Pakistan. RESULTS: The urban respondents had higher knowledge about Coronavirus
disease as compared to rural respondents. Similarly, the hygienic behavior of urban respondents was better than rural respondents. But unavailability of hygienic material (mask and hand sanitizer) was the main problem faced by the general public. Public transportation
was considered the most risk-prone place to COVID-19 by the respondents. Majority of the respondents perceived medium to highest risk from COVID-19, and it was found one of the most influential factors affecting the adoption of precautionary measures along
with knowledge of this pandemic. |
|
|
Harrison, SL, Fazio-Eynullayeva, et al |
PLoS medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
he objective of this study was to determine associations between comorbidities listed in the Charlson comorbidity index
and mortality among patients in the United States with COVID-19. METHODS AND FINDINGS: A retrospective cohort study of adults with COVID-19 from 24 healthcare organizations in the US was conducted. The study included adults aged 18-90 years with COVID-19 coded
in their electronic medical records between January 20, 2020, and May 26, 2020. RESULTS: The most common comorbidities listed in the Charlson comorbidity index were chronic pulmonary disease and diabetes mellitus. Older age, male sex, and being black or African
American (compared to being white) remained significantly associated with higher odds of death in age-stratified analyses. |
|
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Fighting fake news in the COVID-19 era: policy insights from an equilibrium model |
Hartley, K, Vu, et al |
Policy Sciences |
Public Health response| Interventions de santé publique |
We introduce a formal mathematical model to understand factors influencing the behavior of social media users when
encountering fake news. The model illustrates that direct efforts by social media platforms and governments, along with informal pressure from social networks, can reduce the likelihood that users who encounter fake news embrace and further circulate it. This
study has implications at a practical level for crisis response in politically fractious settings and at a theoretical level for research about post-truth and the construction of fact. |
|
Anxiety among doctors during COVID-19 pandemic in secondary and tertiary care hospitals |
Hasan, SR, Hamid, et al |
Pakistan Journal of Medical Sciences |
Healthcare Response | Réponse des soins de santé |
Objective: To assess the level of anxiety among doctors during COVID-19 pandemic and the associated risk factors. Methods:
This cross-sectional study was conducted from 30th April to 16th May, 2020 in Karachi, Pakistan. The data was collected via an online web-based questionnaire. Questionnaire was used to assess anxiety level using GAD-7 scale among health-care professionals
and the risk factors playing role in it. Results: Out of these 151 participants, 69 (45.7%) had mild, 22 (14.6%) had moderate, and 5 (3.3%) had severe symptoms of anxiety, whereas the remaining 55 (36.4%) had no anxiety according to GAD-7 scale. Females showed
more severe degrees of measurement of anxiety symptoms than males. Doctors dealing with COVID-19 patients showed higher level of anxiety as compared to the doctors who were not dealing with COVID-19 patients, having a significant difference |
|
A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts
against SARS-CoV-2 |
Hassan, AO, Kafai, et al |
Cell |
Vaccine Research| Recherche sur les vaccins Immunology | Immunologie Animal model |
Modèle animal |
We evaluated the protective activity of a chimpanzee adenovirus-vectored vaccine encoding a prefusion stabilized spike
protein (ChAd-SARS-CoV-2-S) in challenge studies with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mice expressing the human angiotensin-converting enzyme 2 receptor. Intramuscular dosing of ChAd-SARS-CoV-2-S induces robust systemic humoral
and cell-mediated immune responses and protects against lung infection, inflammation, and pathology but does not confer sterilizing immunity, as evidenced by detection of viral RNA and induction of anti-nucleoprotein antibodies after SARS-CoV-2 challenge.
In contrast, a single intranasal dose of ChAd-SARS-CoV-2-S induces high levels of neutralizing antibodies, promotes systemic and mucosal immunoglobulin A (IgA) and T cell responses, and almost entirely prevents SARS-CoV-2 infection in both the upper and lower
respiratory tracts. Intranasal administration of ChAd-SARS-CoV-2-S is a candidate for preventing SARS-CoV-2 infection and transmission and curtailing pandemic spread. |
|
The Metabolic Changes and Immune Profiles in Patients With COVID-19 |
He, B, Wang, et al |
Frontiers in Immunology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
To explore the metabolic changes and immune profiles in patients with COVID-19, we analyzed the data of patients with
mild and severe COVID-19 as well as young children with COVID-19. Of the leukocytes, 47% were lymphocytes 2.5 × 109/L, and monocytes were 0.51 × 109/L in young children with COVID-19. In 32 mild COVID-19 patients, circulating monocytes were 0.45 × 109/L. Twenty-one
severe patients had low PO2 57 mmHg and SO2 90% and high lactate dehydrogenase, cardiac troponin I, and pro-BNP. Serum D-dimer and FDP were 9.89 mg/L and 32.7 mg/L, and a large number of RBC was presented in urine, a cue of disseminated intravascular coagulation
(DIC) in severe patients. In the late stage of COVID-19, severe cases had extremely low CD4+ T cells and CD8+ T cells, but unusually high neutrophils, procalcitonin, C-reactive protein and an extremely high level of interleukin-6. |
|
A critically ill mother with COVID-19 in late pregnancy: a case report |
He, S, Wang, et al |
Chinese Journal of Perinatal Medicine |
Clinical data| Données cliniques |
Case report of a 32 year old pregnant female |
|
He, Z, Chen, et al |
International Journal of Biological Sciences |
Healthcare Response | Réponse des soins de santé |
An integrated psychological intervention model coined ‘COVID-19 Psychological Resilience Model’ was developed in Chengdu,
China including live media, 24-hour hotline consultations, online video intervention and on-site crisis intervention sessions to provide services to those in need. A total of 45 episodes of live media programs on COVID-19 outbreak-related psychological problems
were broadcasted with over 10 million views. A total of 4,236 hotline consultations were completed. More than 50% of the clients had positive feedback about the hotline consultations. A total of 223 cases received online video intervention, of which 84.97%
were redirected from the hotline consultation and 15.03% from COVID-19-designated hospital and community-based observation spots. Seventy one-on-one psychological interventions were conducted with 39 COVID-19 patients, and one-third were treated with medication. |
|
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Challenges Experienced by Older People During the Initial Months of the COVID-19 Pandemic |
Heid, AR, Cartwright, et al |
Gerontologist |
Public Health response| Interventions de santé publique |
METHODS: From May 4 to May 17, 2020, a web-based questionnaire focused on the COVID-19 pandemic was completed by 1,272
people (aged 64+) who were part of an on-going research panel in New Jersey recruited in 2006. Frequencies for endorsement of physical distancing behaviors were tabulated and open-ended responses to the biggest challenge of the pandemic were systematically
coded and classified using content analysis. RESULTS: More than 70% of participants reported adhering to physical distancing behaviors. Experiences appraised as most difficult by participants fell into eight domains: Social Relationships, Activity Restrictions,
Psychological, Health, Financial, Global Environment, Death, and Home Care. The most frequently appraised challenges were constraints on social interactions (42.4%) and restrictions on activity (30.9%). |
|
Heilingloh, CS, Aufderhorst, et al |
American Journal of Infection Control |
Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
We determined the susceptibility of SARS-CoV-2 to irradiation with ultraviolet light. The virus was highly susceptible
to ultraviolet light. A viral stock with a high infectious titer of 5 × 106 TCID50/mL was completely inactivated by UVC irradiation after nine minutes of exposure. The UVC dose required for complete inactivation was 1,048 mJ/cm2. UVA exposure demonstrated
only a weak effect on virus inactivation over 15 minutes. Hence, inactivation of SARS-CoV-2 by UVC irradiation constitutes a reliable method for disinfection purposes in health care facilities and for preparing SARS-CoV-2 material for research purpose. |
|
|
Hendren, EM, Matthews, et al |
Canadian Journal of Kidney Health and Disease |
Clinical data| Données cliniques |
Case report of a 66 year old female on dialysis with COVID-19 |
|
|
Herrmann, M, Schulte, et al |
Frontiers in Immunology |
Clinical data| Données cliniques Immunology | Immunologie |
Following the hypothesis that T cells in COVID-19 might have a similar, dual function, we comprehensively characterized
the differentiation (CCR7, CD45RO) and activation status (HLA-DR, CD38, CD69, CD226), the co-expression of co-inhibitory molecules (PD1, TIM-3, LAG-3, BTLA, TIGIT), as well as the expression pattern of the transcription factors T-bet and eomes of CD8+ and
CD4+ T cells of PBMC of n = 20 SARS-CoV-2 patients compared to n = 10 P. falciparum infected patients and n = 13 healthy controls. Overall, acute COVID-19 and malaria infection resulted in a comparably elevated activation and altered differentiation status
of the CD8+ and CD4+ T cell populations. T effector cells of COVID-19 and malaria patients showed higher frequencies of the inhibitory receptors T-cell immunoglobulin mucin-3 (TIM-3) and Lymphocyte-activation gene-3 (LAG-3) which was linked to increased activation
levels and an upregulation of the transcription factors T-bet and eomes. COVID-19 patients with a more severe disease course showed higher levels of LAG-3 and TIM-3 than patients with a mild disease course. |
|
|
Hetkamp, M, Schweda, et al |
Sleep medicine |
Public Health response| Interventions de santé publique |
Methods: Aim of this web-based survey was to assess the mental health burden of the German public over a period of
50 days after the COVID-19 outbreak. 16,245 individuals responded regarding sleep disturbances, COVID-19-fear, and generalized anxiety disorder (GAD-7). Data were put in relation to infection rates, number of deaths and the German stock index. Results: The
specific fear increased rapidly in concordance with infection numbers. However, no relation to the number of deaths was found, COVID-19-fear developed reversed to the stock index. Initially, 13.5% of the respondents reported a reduced sleep quality, and 7.2%
a moderate generalized anxiety; proceeding simultaneously with high peaks. Finally, more than twice as many respondents showed psychological burdens. |
|
|
Hirose, Hideo |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper shows that the generalized logistic distribution model is derived from the SIR model under certain conditions.
In the SIR model, there are uncertainties in predicting the final values for the number of infected population and the infectious parameter. However, by utilizing the information obtained from the generalized logistic distribution model, we can perform the
SIR numerical computation more stably and more accurately. Applications to SARS and COVID-19 using this combined method are also introduced. We have fitted the generalized logistic distributions to observed values of cumulative number of infected persons,
cumulative number of died persons and cumulative number of recovered persons. We see that the infection spreads very quickly, but recovered slowly. From the infection to recover, it took three weeks referring the median time of infection curve and recovered
curve. |
|
|
Homolka, S, Paulowski, et al |
Emerg Infect Dis |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We analyze the potential of using TB diagnostic and research infrastructures for severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) testing. We focused on quality control by adapting the 12 Quality System Essentials framework to the COVID-19 and TB context. We conclude that diagnostic infrastructures for TB can in principle be leveraged to scale-up SARS-CoV-2
testing, in particular in resource-poor settings. TB research infrastructures also can support sequencing of SARS-CoV-2 to study virus evolution and diversity globally. |
|
|
Hong, S, Ai, et al |
Nursing outlook |
Healthcare Response | Réponse des soins de santé |
This study aimed to assess the immediate psychological impact on frontline nurses in China. Methods: A multicenter,
cross-sectional survey of frontline nurses was conducted via online questionnaires. Symptoms of depression, anxiety, somatic disorders, and suicidal ideation were evaluated. Demographic, stress, and support variables were entered into logistic regression analysis
to identify the impact factors. Findings: Of the 4,692 nurses who completed the survey, 9.4% (n = 442) were considered to have depressive symptoms, 8.1% (n = 379) represented anxiety, and 42.7% (n = 2,005) had somatic symptom. About 6.5% (n = 306) respondents
had suicidal ideation. |
|
|
Householder, Jacob, Householder, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Our group applied an unsupervised machine learning technique to identify COVID-19 cases. Our experiments utilize
Principal Component Analysis (PCA), t-distributed Stochastic Neighbor Embedding (t-SNE), and the recently developed Robust Continuous Clustering algorithm (RCC). We display the performance of RCC in identifying COVID-19 patients and its ability to compete
with other unsupervised algorithms, namely K-Means++ (KM++). Using a COVID-19 Radiography dataset, we found that RCC outperformed KM++; we used the Adjusted Mutual Information Score (AMI) in order to measure the effectiveness of both algorithms. The AMI for
the two and three class cases of KM++ were 0.0250 and 0.054, respectively. In comparison, RCC scored 0.5044 in the two class case and 0.267 in the three class case, clearly showing RCC as the superior algorithm. |
|
|
Political partisanship and mobility restriction during the COVID-19 pandemic |
Hsiehchen, D, Espinoza, et al |
Public health |
Public Health response| Interventions de santé publique |
Non-pharmaceutical interventions (NPIs) are effective in curbing the spread of severe acute respiratory syndrome coronavirus
2. All US states have adopted NPI policies, but the compliance to these measures and influence of sociopolitical factors on NPI adherence is unknown. NPI adherence may be approximated by personal mobility in a population that is tracked by anonymous mobile
phone data. Study design: This is a cross-sectional study of state-level mobility changes across the US. Methods: State-level mobility was based on anonymous mobile phone data from multiple participating carriers collected by the University of Washington's
Institute for Health Metrics and Evaluation. Results: All states experienced a decline in personal mobility but had varying nadirs ranging from a 34% to a 69% reduction in mobility, which was not temporally related to the timing of state-level NPI measures.
There was a statistically significant linear and negative correlation (r = −0.79) between the proportion of Republicans/leaning Republicans and NPI adherence across US states. The negative association between Republicans and NPI adherence was significant even
when adjusting for urbanization, proportion of essential workers, population, Gini index, and poverty rates. |
|
Hu, Y, Zhang, et al |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University |
Public Health response| Interventions de santé publique |
METHODS: We invited the participants from Hubei and Henan Provinces of China for an internetbased survey starting from
12:00 on February 21, 2020 to 12:00 on February 23. The survey included the general conditions, KAP of COVID-19, psychological status and living conditions of the residents. RESULTS: Social media were the most important source of information concerning the
pandemic of the respondents. The respondents had a high awareness of person-to-person transmission of the virus through the respiratory tract or droplets but showed a relatively low level of awareness of the population susceptible to COVID-19 and its specific
symptoms. The results of multivariate analysis showed that women, undergraduate students (including college students) and higher degree holders had better knowledge of COVID-19. the proportion of respondents who expressed to have different levels of psychological
stressed such as worry, anxiety and panic reached 77.2%; 16.7% of the responders considered psychological interventions necessary for their psychological conditions; 63.6% of the respondents confessed a bias against the people returning from Hubei and Henan
provinces, while 22.4% worried that they might be biased because of their residence in Hubei and Henan. |
|
|
Huang, Y, Ding, et al |
Science of the Total Environment |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to detect pathogens in biological and environmental samples of these asymptomatic infected individuals
and analyse their association. Using a cross-sectional study design, we collected biological and environmental samples from 19 patients treated in the isolation ward of Nanjing No.2 Hospital. As results, 19 asymptomatic infected individuals participated in
the survey, with 8 positives for pathogens and 11 positives only for antibodies. Three positive samples were detected from among 96 environmental samples, respectively, from a cell phone surface, a cell phone shelf and a bedside handrail. No positive samples
were detected in the exhaled breath condensate in this work. All patients identified pathogens in the environment had positive anal swabs. There was a statistical association between positive anal swabs and positive environmental samples. The association of
positive samples from the surrounding of asymptomatically infected patients with positive anal swabs suggested that patients might secrete the virus for a more extended period. |
|
|
Huang, Y, Wang, et al |
Frontiers in Psychiatry |
Public Health response| Interventions de santé publique |
This study aimed to identify the prevalence of anxiety, somatization and insomnia and explore the relationships between
different psychological states in the general population during the COVID-19 outbreak. A total of 1,172 respondents were recruited from 125 cities in mainland China by an online questionnaire survey. The prevalence of somatization was 19.38% in participants
with anxiety. Multivariate logistic regression showed that GAD-7 score, ISI score, and age were risk factors for somatization in the anxious population. |
|
|
Convalescent plasma therapy for B-cell depleted patients with protracted COVID-19
disease |
Hueso, T, Pouderoux, et al |
Blood |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We report a series of 17 consecutive patients with profound B-cell lymphopenia and prolonged COVID-19 symptoms, negative
IgG-IgM SARS-CoV-2 serology and a positive RNAemia measured by digital PCR who were treated with four units of COVID-19 convalescent plasma. Within 48 hours following transfusion, all patients except one experienced an amelioration of their clinical symptoms.
The inflammatory syndrome abated within a week. Only one patient who needed mechanical ventilation for severe COVID-19 disease died of bacterial pneumonia. SARS-CoV-2 RNAemia decreased to below the sensitivity threshold in 9 out of 9 evaluated patients. Analysis
of virus-specific T-cell responses using T-cell enzyme linked immunoSpot (ELISPOT) assay was analyzed before convalescent plasma transfusion in 3 patients. All showed a conserved SARS-CoV-2 T-cell response and poor cross-response to other coronaviruses. No
adverse event was reported. |
|
On the verge of life: Distribution of nucleotide sequences in viral RNAs |
Husev, Mykola, Rovenchak, et al |
arXiv |
Coronavirology| Coronavirologie |
The aim of the study is to analyze viruses using parameters obtained from distributions of nucleotide sequences in
the viral RNA. Seeking for the input data homogeneity, we analyze single-stranded RNA viruses only. Two approaches are used to obtain the nucleotide sequences; In the first one, chunks of equal length (four nucleotides) are considered. In the second approach,
the whole RNA genome is divided into parts by adenine or the most frequent nucleotide as a "space". Rank--frequency distributions are studied in both cases. Within the first approach, the Pólya and the negative hypergeometric distribution yield the best fit.
For the distributions obtained within the second approach, we have calculated a set of parameters, including entropy, mean sequence length, and its dispersion. The calculated parameters became the basis for the classification of viruses. We observed that proximity
of viruses on planes spanned on various pairs of parameters corresponds to related species. In certain cases, such a proximity is observed for unrelated species as well calling thus for the expansion of the set of parameters used in the classification. We
also observed that the fourth most frequent nucleotide sequences obtained within the second approach are of different nature in case of human coronaviruses (different nucleotides for MERS, SARS-CoV, and SARS-CoV-2 versus identical nucleotides for four other
coronaviruses). |
|
Huynh, G, Nguyen, et al |
Risk Management and Healthcare Policy |
Public Health response| Interventions de santé publique |
This cross-sectional study aims to assess the knowledge, attitude, and practices regarding COVID-19 among people with
chronic diseases at the outpatient departments in Ho Chi Minh City. A total of 522 participants had a mean age of 51.5 ± 10.6 years. Most of them reported seeing information regarding the COVID-19 pandemic (93.7%) via television and social media (72.8% and
62.1%, respectively). Just over two-thirds of the participants (68.4%) answered with sufficient knowledge of COVID-19. Most respondents had a positive attitude toward COVID-19 (90.8%), although some misconceptions existed. Almost over three-fourths of them
(77.2%) maintained good practices for prevention. The rate of good practices in those who had sufficient knowledge was 1.24 times greater than that among those who had insufficient knowledge (PR 1.24, 95% CI: 1.10–1.41, P<0.05). Also, the rate of good practices
in males was lower than that of females (PR: 0.91, 95% CI: 0.83–0.99, P<0.05). |
|
|
Hyseni, I, Molesti, et al |
Viruses |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
After fully characterising lentiviral pseudotypes bearing the SARS-CoV-2 spike protein, we employed them in pseudotype-based
neutralisation assays in order to profile the neutralising activity of human serum samples from an Italian sero-epidemiological study. The results obtained with pseudotype-based neutralisation assays mirrored those obtained when the same panel of sera was
tested against the wild type virus, showing an evident convergence of the pseudotype-based neutralisation and MN results. The overall results lead to the conclusion that the pseudotype-based neutralisation assay is a valid alternative to using the wild-type
strain, and although this system needs to be optimised and standardised, it can not only complement the classical serological methods, but also allows serological assessments to be made when other methods cannot be employed, especially in a human pandemic
context. |
|
|
Ibrahim, S, Kamaruddin, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Modelling/ prediction| Modélisation/prédiction Transmission |
This paper aims to establish a performance evaluation of Multilayer Perceptron (MLP) and a Radial Basis Function (RBF)
networks in investigating the contributing factors for COVID-19 spread and death. The RBF and MLP networks are typically used in the same form of applications, however, their internal calculation structures are different. A comparison was made by using a dataset
of COVID-19 cases in 41 Asia countries during April 2020. There are nine contributing factors which acted as the covariates to the network such as Cases, Deaths, High Temperature, Low Temperature, Population, Percentage of Cases over Population, and Percentage
of Death over Population, Average Temperature, and Total Cases. The results obtained from the testing sets indicated that the two neural structures were able to investigate the COVID-19 spread and death contributing factors. Nevertheless, the RBF network indicated
a slightly better performance than the MLP. |
|
|
The influences of global geographical climate towards COVID-19 spread and
death |
Ibrahim, S, Kamaruddin, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Modelling/ prediction| Modélisation/prédiction Transmission |
We proposed to investigate the influences of the global geographical climate towards the COVID-19 spread and death
using a technique of Artificial Neural Network (ANN). It is believed that the proposed study could introduce a new suggestive strategy in improving the precaution measures, enhancing the new normal living activities, and to increase the performance scalability
of big data processing comprehensively. |
|
Iodice, V, Pisaturo, et al |
Le infezioni in medicina |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Our study aimed to investigate the clinical performance of LUS in the initial evaluation of pneumonia in COVID-19 patients,
compared to standard U-HR-CT. Among 29 patients with confirmed COVID-19, all U-HR-CT hallmarks showed an excellent concordance with LUS findings according to Cohen coefficient. In our experience, LUS is a viable alternative to U-HR-CT, with the advantages
of being radiation-free, flexible, cost-effective, and reasonably reducing nosocomial transmission risks because performed at bed-side. |
|
|
Association between trace levels of lithium in drinking water and COVID-19-associated mortality |
Ishii, N, Terao, et al |
Bipolar Disord |
Epidemiology| Épidémiologie |
This preliminary study investigates whether trace lithium, such as that in drinking water, may be associated with
a low COVID-19 mortality. After adjusting for the relevant factors using a stepwise method, the model could predict COVID-19 standard mortality rates (SMRs) with statistical significance (F=42.1, p<0.001). However, the lithium level was not a significant contributor
to the COVID-19 SMR (B=0.073, p=0.367). Among the relevant factors, only the proportion of elderly people (B=0.629 p<0.001) and the proportion of one-person households (B-0.334 p=0.002) were significant contributors. |
|
The early impact of covid-19 on urological service
provision |
Jain, A, Croghan, et al |
Irish medical journal |
Healthcare Response | Réponse des soins de santé |
We aimed to observe the impact on urological care delivery in an Irish university hospital. Over the 2020 study period,
356 urological admissions were recorded; a 23.1% decrease from the 2019 corresponding period (n=463). A 21.7% decrease in flexible cystoscopies was seen (162 versus 207). 125 theatre cases (36 off-site) were performed in the 2020 period, versus 151 in 2019.
Emergency case load remained stable, with 69 cases in the 2020 period. The percentage of trainee-performed cases was preserved. COVID-era outpatient activity increased, to involve 559 clinic consultations compared to 439 the preceding year; a reflection of
annual growth in service demand and facilitated by virtual clinic application (n=403). There were 490 instances of patients cancelling/failing to attend outpatient appointments, compared to 335 in 2019. |
|
Jayakumar, N, Kennion, et al |
World Neurosurgery |
Healthcare Response | Réponse des soins de santé |
Our aim was to describe the referral patterns to a high-volume neurosurgical department in the United Kingdom during
the COVID-19 pandemic. A total of 2293 electronic referrals had been received during the study period. The median age was 63 years. Overall, the referrals had decreased significantly in volume during the study period χ2(4) = 60.95; P < 0.001]. We have described
the patterns in the daily referrals as the pandemic progressed. The reduction in the volume of referrals for degenerative spine cases and traumatic brain injuries was statistically significant (P < 0.001). |
|
|
Real Asymptomatic SARS-CoV-2 Infection Might Be Rare: Importance of Careful Interviews
and Follow-up |
Jeong, TH, Pak, et al |
J Korean Med Sci |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We performed a retrospective case series of patients with COVID-19 enrolled from February 22 to March 26, 2020. Forty
patients were included (median age, 30 years; interquartile range IQR], 25-57 years; 58% female). Six (15%) patients required supplemental oxygen. The prevalence of asymptomatic severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection was 5%
and that of presymptomatic infection was 13%. Cough, fever, myalgia, rhinorrhea or nasal congestion, and diarrhea were the screening criteria for diagnosing symptomatic and presymptomatic SARS-CoV-2 infections. Sputum production, chest discomfort, a large
number of symptoms, abnormal procalcitonin and C-reactive protein levels, and abnormal chest X-ray or chest computed tomography findings were more common in patients requiring supplemental oxygen than in those not requiring supplemental oxygen. Overall mortality
rate was 3% (1/40). Four patients (10%) were readmitted after testing positive by reverse-transcription polymerase chain reaction again. Incubation period was 5 days (IQR, 4-6 days), and the duration of viral shedding was 21 days (IQR, 14-28 days; maximum,
51 days). |
|
Glucocorticoid therapy does not delay viral clearance in COVID-19 patients |
Ji, J, Zhang, et al |
Crit Care |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This cohort study analyzed clinical data from 684 adult patients with SARS-CoV-2 infections confirmed through RT-PCR
on throat swab samples collected between January and March 2020 from two hospitals in Wuhan, China. The current multicenter cohort study demonstrates that Glucocorticoid (GC) therapy does not change viral clearance and peripheral lymphocyte counts in COVID-19
patients. However, well-designed and large-scale randomized controlled trials are needed to further confirm the results derived from this observational study |
|
Jia, H, Huo, et al |
Environmental Pollution |
Public health interventions*| Interventions de santé publique |
This study aimed to investigate chemical characteristics, abatement mechanisms and regional transport of atmospheric
pollutants during the COVID-19 outbreak control period in the Yangtze River Delta (YRD) region, China. Due to the stricter outbreak control, the levels of PM2.5 and VOCs, and the occurrence frequencies of haze-fog episodes decreased substantially from NCP
to CP, with average reduction rates of 31.6%, 38.9% and 35.1% at PD, and 34.5%, 50.7% and 37.9% at DSL, respectively. The major source for PM2.5 was secondary sulfate & nitrate in both periods, and the emission control of primary sources such as coal burning
and vehicle exhaust decreased the levels of precursors gas sulfur dioxide and nitrogen oxide, which highly contributed to the abatement of PM2.5 from NCP to CP. The higher levels of ozone at both PD and DSL on CP might be due to the weak nitrogen monoxide
titration, low relative humidity and high visibility compared with NCP. Vehicle exhaust and fugitive emission from petrochemical industry were the major contributors of ambient VOCs and their decreasing activities mainly accounted for VOCs abatement. Moreover,
the high frequency of haze-fog events was closely impacted by medium-scale regional transport within Anhui and Jiangsu provinces. |
|
|
Joy, M, Malavika, et al |
Clinical Epidemiology and Global Health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
The objective of our study was to determine the association between BCG vaccine coverage and incidence of COVID-19
at a national-level across the Globe. The countries that had ≤70% coverage of BCG vaccine reported 6.5 (95% CI: −8.4 to −4.5) less COVID-19 infections per 10,000 population as compared to countries that reported no coverage. Those that had >70% coverage reported
10.1 (95% CI: −11.4 to −8.7) less infections per 10,000 population compared to those with no BCG countries. |
|
|
Clinical Performance of A Semi-Quantitative Assay for SARS-CoV2 IgG and SARS-CoV2
IgM Antibodies |
Jung, J, Garnett, et al |
Clin Chim Acta |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Authors report on the validation of the Ansh Laboratories SARS-CoV-2 IgG and SARS-CoV-2 IgM ELISA immunoassays. The
IgG and IgM ELISA assays showed acceptable precision, were robust to analytical interference and did not exhibit cross reactivity with specimens positive for common respiratory viruses. Both assays exhibited 95% agreement with a primary screening serological
assay utilized at our institution as well as with a reference laboratory semi-quantitative method. Concordance with RT-PCR was excellent >6 days after symptom onset (100%). |
|
Kamel Abd, R, Raman, et al |
Revista de Salud Publica |
Public Health response| Interventions de santé publique |
This cross-sectional study was conducted to find out the extent of commitment among the Iraqi people to the standards
of prevention measures against COVID-19. The results showed that the majority of the respondents (52%) were female, and most of them (42.3%) were observed between the age group of 31-40 years. About 82% of the respondents were residents of urban areas. This
study reveals the excellent implementation of preventive measures by the population. |
|
|
Kanduc, D, Shoenfeld, et al |
Immunol Res |
Coronavirology| Coronavirologie Animal model | Modèle animal |
This study comparatively analyzed the peptide sharing between SARS-CoV-2 and mammalian species. This study thoroughly
quantifies the hexa- and heptapeptide sharing of SARS-CoV-2 spike glycoprotein—which is a major antigen of the virus—with mammalian proteomes. In light of the data exposed in this study and given the susceptibility parameters such as aging and health status,
only aged mice appear to be a correct animal model for testing an anti-SARS-CoV-2 spike glycoprotein vaccine to be used in humans |
|
|
Kanji, JN, Chichak, et al |
JAMMI |
Clinical data| Données cliniques |
As the pandemic of coronavirus disease 2019 (COVID-19) continues to evolve globally and within our Canadian borders,
hospitals will begin to see an increasing number of confirmed or suspected cases at their doors. Although many patients can be managed at home, a reasonable proportion will experience progression of disease requiring hospitalization and potentially mechanical
ventilation and intensive care. Herein, we report the presentation of the first case of COVID-19 admitted to hospital in Alberta. While The patient's course was mild, this case highlights a number of key points—namely the importance of widespread testing in
the community to help inform emergency services (ambulance) workers and receiving front-line health care staff. Other important points include in-hospital monitoring and pharmacologic treatment. © 2020, University of Toronto Press Inc.. All rights reserved. |
|
|
Karimi, M, Haghpanah, et al |
Acta bio-medica : Atenei Parmensis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Authors evaluated the prevalence and the impact of comorbidities in thalassemia Iranian patients affected by COVID-19.
It is important to acknowledge that β-thalassemia patients, especially young adults/adults, have a chronic condition which may contribute to increase susceptibility to SARS-CoV-2 infection. |
|
|
Karl, M, Muskat, et al |
Journal of Destination Marketing and Management |
Public Health response| Interventions de santé publique |
The paper examines which travel risks are more salient for tourists' destination choice during COVID-19. This paper
concludes with implications for the tourism practice with recommendations on how to manage travel risk and decision-making behaviours in the post-COVID-19 phase. |
|
|
Kartsios, C, Lokare, et al |
Journal of thrombosis and thrombolysis |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
In this audit authors sought to distinguish COVID-19 hospitalised patients with a diagnosis of venous thromboembolism
(VTE) and record their outcomes over a period of 3 months. Results suggest that direct anticoagulants could be a safe and effective treatment option in selected COVID-19 positive patients who have suffered venous thromboembolism. |
|
|
The changes in the effects of social media use of Cypriots due to COVID-19 pandemic |
Kaya, T |
Technology in Society |
Public Health response| Interventions de santé publique |
This research aims at uncovering the influences of social media use in several dimensions during lockdown(s). This
research indicates that respondents' social media use during COVID-19 is different from normal times as a common purpose triggers this, survival. |
|
Khak, M, Shakiba, et al |
Asian Journal of Sports Medicine |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
The study of alterations in the epidemiological pattern of traumatic injuries during the COVID-19 crisis can provide
estimates in the planning of healthcare resources. There were important epidemiological changes during the COVID-19 crisis in trauma patients. The cessation of sports activities resulted in a reduction in ligamentous injuries of sports origin. Women better
implemented the stay-at-home strategies shown by a sudden increase in the men to women ratio of risk-taking traumatic injuries. The decreased number of patients with soft-tissue injuries and a high rate of self-discharge must inform the authorities of the
fear of in-hospital contamination. |
|
|
Khan, AR, Chishti, et al |
International Journal of Pervasive Computing and Communications |
Public health interventions*| Interventions de santé publique |
The purpose of this study is to exploit the lowest common ancestor technique in an m-ary data aggregation tree in the
fog computing-enhanced IoT to assist in contact tracing in COVID-19. It is found from the results that a carrier can be easily identified from the samples collected using the approach designed in the paper. |
|
|
Khan, MA, Abbas, et al |
Computers, Materials and Continua |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This work proposes and examines a prediction model for COVID-19 based on a deep extreme learning machine (DELM). Results
show that the new methodology is useful in developing an appropriate forecast when the samples are far from abundant during the critical period of the disease. |
|
|
Kharshiing, KD, Kashyap, et al |
Community Ment Health J |
Public Health response| Interventions de santé publique |
In this study the role of individual variables (COVID-19 anxiety, perceived susceptibility, perceived severity, optimistic
bias and personal identity) as predictors of quality of life (QoL) during the novel coronavirus or COVID-19 pandemic is explored. Findings would indeed, aid in the rehabilitation and assistance of people to live in COVID-19 crisis, and thereafter. |
|
|
Khorsand, B, Savadi, et al |
Informatics in Medicine Unlocked |
Coronavirology| Coronavirologie |
Authors develop a model to predict the behaviour of COVID-19 that uses a three-layer network in which the first layer
contains the most similar Alphainfluenzavirus proteins to SARS-CoV-2 proteins. Differentially expressed genes of previous researches were investigated and protein-protein interaction (PPI) of SARS-CoV-2-human network, the human proteins of which were related
to upregulated genes, were reported. |
|
|
Air and Environmental Contamination Caused by COVID-19 Patients: a Multi-Center
Study |
Kim, UJ, Lee, et al |
J Korean Med Sci |
Epidemiology| Épidémiologie Transmission Healthcare Response | Réponse des soins de
santé |
The purpose of this study was to determine the extent of air and surface contamination of COVID-19 in four health care
facilities with hospitalized COVID-19 patients. Data suggest that remote airborne transmission of SARS-CoV-2 from hospitalized COVID-19 patients is uncommon when aerosol-generating procedures have not been performed. |
|
Kim, YS, Lee, et al |
BMB Rep |
Therapeutics| Thérapeutique |
Combination therapy using chloroquine (CQ) and azithromycin (AZM) has drawn great attention due to its potential anti-viral
activity against COVID-19. To elucidate the cardiotoxicity induced by CQ and AZM , authors examined the effects of these drugs based on the electrophysiological properties of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) using multi-electrode
arrays. In support of the clinical data suggesting the cardiovascular side effects of the combination therapy of CQ and AZM, our results suggest that AZM reinforces the cardiotoxicity induced by CQ in hESC-CMs. |
|
|
PMC7491376; Recovery from the COVID-19 pandemic: Distress and resilience |
Kimhi, S, Marciano, et al |
Int J Disaster Risk Reduct |
Public Health response| Interventions de santé publique |
This study analyzed repeated responses to COVID-19. The sample size was 300 people. Results indicated four significant
differences between the first and the second measurements: Sense of danger, distress symptoms, and national resilience significantly decreased, while perceived well-being increased at T2. No significant differences were noted between the two measurements regarding
individual and community resilience and economic difficulties. The data indicated that the highest decrease in national resilience was accounted for by low respondent trust in governmental decisions during the COVID-19 crisis. |
|
32896604; Effectiveness of 222-nm ultraviolet light on disinfecting SARS-CoV-2
surface contamination |
Kitagawa, H, Nomura, et al |
American Journal of Infection Control |
Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
This study aimed to investigate the in vitro efficacy of 222-nm far-ultraviolet light (UVC) on the disinfection of
SARS-CoV-2 surface contamination. This study shows the efficacy of 222-nm UVC irradiation against SARS-CoV-2 contamination in an in vitro experiment. |
|
Klopfenstein, T, Zayet, et al |
International Journal of Infectious Diseases |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Authors conducted a retrospective case-control study in the Nord Franche-Comté Hospital, France to determine if Tocilizumab
(TCZ) in patients with severe COVID-19 could be an effective treatment. Results suggests that TCZ reduces mortality and/or IMV requirement in patients with severe SARS-CoV-2 pneumonia. |
|
|
Kong, Q, Yan, et al |
Risk Management and Healthcare Policy |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
Authors described COVID-19 prevention and control strategies that have been implemented in a tertiary hospital in the
middle east of China to determine effective measures for prevention and control of nosocomial infection to control COVID-19 infection among medical staff. The report provides a protocol that could be implemented in medical departments in similar cities worldwide. |
|
|
Kong, X, Cao, et al |
Nursing Open |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to investigate the psychological status of medical staff with medical device-related nasal
and facial pressure ulcers (MDR PUs) during the outbreak of COVID-19, analyze the correlation between their psychological status and personality traits, so as to provide a reference for personalized psychological support. Medical staff wearing protective
equipment are particularly susceptible to nasal and facial MDR PUs, which is increasing their social appearance anxiety; neuroticism is significantly related to social appearance anxiety and negative emotion. |
|
|
Korem, S, Gandhi, et al |
BMJ Case Rep |
Clinical data| Données cliniques |
Clinical manifestations of COVID-19 are known to be variable with growing evidence of nervous system involvement. In
this case report, we describe the symptoms of a patient infected with SARS-CoV-2 whose clinical course was complicated with Guillain-Barré syndrome (GBS). We present a case of a 58-year-old woman who was initially diagnosed with COVID-19 pneumonia due to symptoms
of fever and cough. Two weeks later, after the resolution of upper respiratory tract symptoms, she developed symmetric ascending quadriparesis and paresthesias. The diagnosis of GBS was made through cerebrospinal fluid analysis and she was successfully treated
with intravenous immunoglobulin administration. |
|
|
Kumar, S, Kashyap, et al |
Phytomedicine |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study aimed to study the binding potential of various phytochemicals present in multiple natural plant extract
as a secondary metabolite to non-structural protein 15 (Nsp15) protein, a drug target known to play a crucial role in virulence of coronavirus. The study successfully demonstrated the binding of phytochemicals such as sarsasapogenin, ursonic acid, curcumin,
ajmalicine, novobiocin, silymarin and aranotin, piperine, gingerol, rosmarinic acid, and alpha terpinyl acetate to Nsp15 viral protein and they might play a key role in inhibiting SARS-CoV-2 replication. |
|
|
Kumaran, M, Geetha, et al |
Aquaculture |
Public Health response| Interventions de santé publique |
An on-line survey was carried out among the stakeholders of the shrimp farming sector to evaluate the prospective impact
of COVID-19 related lockdown across the shrimp supply chain. The study estimated an economic loss of 1.50 billion USD to the shrimp aquaculture sector during the current year. It is expected that shrimp production and its export performance may be declining
by 40% in the current season. |
|
|
Another
look at a good approximation of data for the distribution of COVID-19 in Cuba |
Kyurkchiev, N, Iliev, et al |
Revista Habanera de Ciencias Medicas |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In the article “Adjustment of population growth curve applied to Covid-19 in Cuba”, the authors propose six types of
models to approximate data from the distribution of COVID-19 in Cuba, while giving a clear answer to the possible advantages of some considerations. In this paper, we study intrinsic properties of some models of growth with polynomial variable transfer that
give a very good approximation of the specific data on the pandemics in Cuba by June 5, 2020. The models have the right to exist in the treatment of issues from different fields of scientific knowledge. Numerical examples are presented using CAS MATHEMATICA.
Creative Commons Atribution–NonComercial 4.0 License |
|
Landry, S, Chartogne, et al |
Sexologies |
Public Health response| Interventions de santé publique |
Authors conducted a prospective survey using two online anonymous self-administered questionnaires – one for people
living in couples and one for people living alone, without sexual partner to investigate the impact of COVID-19 on sexuality. Results of this study highlight changes in sexual habits in both couples and those without partners during this period. |
|
|
Lang, G, Su, et al |
Open Forum Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study investigated epidemiological, clinical, and radiological characteristics of COVID-19 with negative RT-PCR
results before confirmation. The study suggests value from early chest CT scans in COVID-19 screening and dynamic significance of radiology in disease monitoring should guide clinical decisions. |
|
|
Lari, E, Lari, et al |
International Journal of Surgery Case Reports |
Clinical data| Données cliniques |
Authors report 5 cases of Covid-19 positive patients with no significant comorbidities who developed 1st time episodes
of either; acute limb ischemia or bowel ischemia. The thromboembolic complications seen in the cases were devastating and resulted in significant mortality and morbidity. |
|
|
Lau, JYC, Khoo, et al |
Am J Case Rep |
Clinical data| Données cliniques |
Authors report the case of a 77-year-old man with a background of asthma-chronic obstructive pulmonary disease (COPD)
overlap syndrome (ACOS) who presented with progressive cough and shortness of breath for 2 days. Interstitial thickening or reticular pattern on CT has been described in COVID-19 pneumonia, but largely in association with ground-glass opacity or consolidation. |
|
|
Pleuropneumonia resulting from varicella and COVID-19 co-infection in a 10-month-old
infant |
Le Roux, P, Millardet, et al |
Archives de Pediatrie |
Clinical data| Données cliniques |
COVID-19 is a new disease leading to respiratory complications in adults. Children appear to have more modest symptoms
than adults. Varicella is often described as a benign disease in the pediatric population. However, patients with varicella and COVID-19 co-infection can develop a more serious respiratory infection. We report the case of an infant who had a co-infection with
both viruses that led to pleuropneumonia. The main question in the present case concerns the link between COVID-19 and varicella infection, and the possible modulation in immune response due to the two virus infections. © 2020 French Society of Pediatrics |
|
Le, HBH, Nguyen, et al |
Management Science Letters |
Economics | Économie |
This research proposes the model of policy - related factors from the action of Chinese government influencing on the
survival and the development of SMEs. Based on the results, the study proposes policy implication in order to support SMEs overcome difficulties during the coronavirus pandemic. |
|
|
Nursing perspectives and strategies in patients with respiratory insufficiency |
Leonardsen, AC, Gulbrandsen, et al |
Nurs Crit Care |
Healthcare Response | Réponse des soins de santé |
This study explored nurses' perspectives on and nursing strategies in patients with respiratory insufficiency when
admitted to three different intensive care units. This study contributes new knowledge about nurses' perspectives on patients with respiratory insufficiency during the COVID-19 pandemic. |
|
Li, T, Deng, et al |
Zhonghua wei zhong bing ji jiu yi xue |
Clinical data| Données cliniques |
The aim of this study was to describe the characteristics of liver damage in severe coronavirus disease 2019 (COVID-19)
patients in Sichuan area and the effect of antiviral drugs on liver function. Severe COVID-19 patients in Sichuan area suffered obvious liver damage in the early course of the disease and have a slower recovery. |
|
|
Li, WJ, Lv, et al |
International journal of medical sciences |
Clinical data| Données cliniques |
This study aimed to determine whether new pulmonary lesions will develop after treatment in patients with COVID-19
pneumonia, and investigate their CT features and outcomes. During treatment, most patients with COVID-19 pneumonia will develop new pulmonary lesions, which usually manifest as multiple GGOs distributed around the primary lesions or in previously uninvolved
lobes, and are subsequently absorbed directly. |
|
|
Racial and ethnic disparities in COVID-19 infections and deaths across U.S. nursing homes |
Li, Y, Cen, et al |
J Am Geriatr Soc |
Epidemiology| Épidémiologie |
The aim of this study was to determine racial/ethnic disparities in weekly counts of new coronavirus disease 2019 (COVID-19)
cases and deaths among nursing home residents or staff. Nursing homes caring for disproportionately more racial/ethnic minority residents reported more weekly new COVID-19 confirmed cases and/or deaths. |
|
Li, Z, Wang, et al |
Journal of infection in developing countries |
Epidemiology| Épidémiologie |
In this study the epidemiological characteristics of imported and local COVID-19 cases in Shenzhen were compared. COVID-19
patients were predominantly imported cases in Shenzhen and the spatial distribution was closely related to district GDP. |
|
|
Liang, Y, Wu, et al |
International journal of environmental research and public health |
Healthcare Response | Réponse des soins de santé |
This study aims to evaluate psychological symptoms in frontline medical workers during the COVID-19 epidemic in China
and to perform a comparison with the general population. A large proportion of frontline medical workers and the general public experienced psychological symptoms during the COVID-19 outbreak. |
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|
Lifshin, U, Mikulincer, et al |
Journal of Social and Clinical Psychology |
Public Health response| Interventions de santé publique |
Authors tested the hypothesis that feelings of helplessness — i.e., the perception that one is unable to control and
prevent negative events — may serve a protective psychological function against fear and anxiety arousal in the context of the COVID-19 pandemic. They discuss the implications for research on the psychological function of helplessness and for understanding
peoples’ responses to the COVID-19 pandemic. |
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32921704; Google search volume predicts the emergence of COVID-19 outbreaks |
Lippi, G, Mattiuzzi, et al |
Acta bio-medica : Atenei Parmensis |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study aimed to explore whether the Google search volume may have been useful to predict the trajectory of coronavirus
disease 2019 (COVID-19) outbreak in Italy. Continuously monitoring the volume of Google searches and mapping their origin can be a potentially valuable instrument to help predicting and identifying local recrudescence of COVID-19. |
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Factors associated with poor forecasting in pregnant women with SARS-Cov-2 diagnosis |
Lira-Lucio, J, Roldán-Rodríguez, et al |
Ginecologia y obstetricia de Mexico |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We describe the associated factors with the degree of severity in pregnant Mexican women reported with SARS-CoV-2 virus
infection. 84 pregnant women were positive to SARS-CoV-2 vs 2,836 non-pregnant infected women in reproductive age. Pregnant women have greater probability to develop a severe form of SAR-CoV-2 infection compared to women in reproductive age. The main associated
factors to severe forms were diabetes and tobacco use. |
|
Liu, C, Li, et al |
Journal for immunotherapy of cancer |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Clinical
data| Données cliniques |
We aimed to develop a nomogram for predicting in-hospital mortality of patients with COVID-19 with solid tumors. A
multivariate logistic regression model was constructed and based on patients with COVID-19 with solid tumors admitted to 32 hospitals in China. There were 216 patients with COVID-19 with solid tumors included in the present study, of whom 37 (17%) died and
the other 179 all recovered. Increasing age, receipt of antitumor treatment within 3 months before COVID-19 diagnosis, elevated WBC count and dNLR, and having dyspnea on admission were independent risk factors for mortality among patients with COVID-19 and
solid tumors. The nomogram based on these factors accurately predicted mortality risk for individual patients. |
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Liu, W, Liu, et al |
J Intern Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We enrolled 140 medical workers with COVID‐19 in Wuhan. Epidemiological, demographic, clinical, laboratory, radiological,
treatment and clinical outcome data were collected, and predictors of the duration of viral shedding were explored through multivariable linear regression analysis. Glucocorticoid treatment and lymphocytes less than 1.1 × 109/L are associated with prolonged
viral shedding. Early admission and rIFN‐α treatment help shorten the duration of viral shedding. |
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Liu, Y, He, et al |
ISPRS International Journal of Geo-Information |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Population migration plays a two-way role in COVID-19 variation. The emigrants’ and immigrants’ population of Wuhan
city accounted for 3.70% and 73.05% of the total migrants’ population respectively; the restriction measures were not only effective in controlling the emigrants, but also effective in preventing immigrants. COVID-19 has significant spatial autocorrelation,
and spatio-temporal differentiation has an effect on COVID-19. |
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|
Longo, C, Ruffini, et al |
Acta bio-medica : Atenei Parmensis |
Clinical data| Données cliniques |
Platypnea-orthodeoxia syndrome (POS) is a clinical entity characterized by positional dyspnoea (platypnea) and arterial
desaturation (orthodeoxia) that occurs when sitting or standing up and usually resolves by lying down. We report a case of POS in a patient after fibrotic evolution of SARS-CoV-2 interstitial pneumonia associated with pulmonary embolism. |
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Lu, H, Lou, et al |
Computers, Materials and Continua |
Public Health response| Interventions de santé publique |
In this paper, we take Sina Weibo, the most widely used online social media in China, for analysis and experiments.
In order to effectively discover what is being discussed about COVID-19 without human labeling, we propose a unified multi-modal framework, including an unsupervised short-text topic model to discover and track bursty topics, and a selfsupervised model to
learn image features so that we can retrieve related images about COVID-19. Experimental results have shown the effectiveness and superiority of the proposed models, and also have shown the considerable application prospects for analyzing and tracking public
opinions about COVID-19. |
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|
Ludzik, J, Witkowski, et al |
F1000Research |
Clinical data| Données cliniques |
Recently, new dermatologic findings have been described in association with COVID-19 that can potentially be a distinguishing
feature of infection. One such feature resembles chilblains and this case report represents a presentation of this feature with a 48-year-old female with violaceous lesions with surrounding pink erythema on her toes who tested negative for COVID-19. |
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|
Luk, MH, Chan, et al |
JBJS case connector |
Clinical data| Données cliniques |
We report our experience of a relatively asymptomatic elderly patient who underwent surgery for a hip fracture and
was confirmed postoperatively to have COVID-19. |
|
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32920347; Intubation, mortality, and risk factors in critically ill Covid-19
patients: A pilot study |
Luo, M, Cao, et al |
Journal of clinical anesthesia |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
We conducted a single-center pilot study based on intubated critically ill Covid-19 patients to explore the risks factors
associated with mortality. 76% of critically ill Covid-19 patients died after non-resuscitative intubation and IMV support. Non-survivors had more comorbidities than survivors. Mortality after non-resuscitative intubation in critically ill Covid-19 patients
is associated with the disease severity at the time of IMV initiation. |
|
Cryo-EM structure of S-Trimer, a subunit vaccine candidate
for COVID-19 |
Ma, Jiahao, Su, et al |
bioRxiv |
Vaccine Research| Recherche sur les vaccins |
Here, using Trimer-Tag technology, we produced both wild21 type (WT) and furin site mutant (MT) S-Trimers for COVID-19
vaccine studies. Cryo22 EM structures of the WT and MT S-Trimers, determined at 3.2 Å and 2.6 Å respectively, revealed that both antigens adopt a tightly closed conformation and their structures are essentially identical to that of the previously solved full-length
WT S protein in detergent. These results validate Trimer-Tag as a platform technology in production of metastable WT S-Trimer as a candidate for COVID-19 subunit vaccine. |
|
Single-cell transcriptomic atlas of primate cardiopulmonary aging |
Ma, S, Sun, et al |
Cell research |
Coronavirology| Coronavirologie |
Here, we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung, heart and artery,
the top tissues targeted by SARS-CoV-2. Our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2, suggesting that geroprotective strategies may reduce
COVID-19 severity in the elderly. |
|
MacIntyre, PD, Gregersen, et al |
System |
Public Health response| Interventions de santé publique |
This article examines the stress and coping responses of an international sample of over 600 language teachers who
responded to an online survey in April 2020. The survey measured stressors and 14 coping strategies grouped into two types, approach and avoidant. Substantial levels of stress were reported by teachers. |
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|
Magazzino, C, Mele, et al |
Appl Energy |
Epidemiology| Épidémiologie |
We investigate the relationship between the COVID-19 outbreak and air pollution. The underlying hypothesis is that
a pre-determined particulate concentration can foster COVID-19 and make the respiratory system more susceptible to this infection. We found new threshold levels of PM2.5 and PM10 connected to COVID-19: 17.4 µg/m3 (PM2.5) and 29.6 µg/m3 (PM10) for Paris; 15.6
µg/m3 (PM2.5) and 20.6 µg/m3 (PM10) for Lyon; 14.3 µg/m3 (PM2.5) and 22.04 µg/m3 (PM10) for Marseille. |
|
|
Mahmud, A, Imaniyati, et al |
International Journal of Psychosocial Rehabilitation |
Public health interventions*| Interventions de santé publique Public Health response|
Interventions de santé publique Economics | Économie |
This study aims to explain the basis for Large-Scale Social Restrictions (LSSR) policy considerations and their implications
for social and economic aspects in Indonesia, and find alternatives to overcome Covid-19. The regional quarantine policy is aggressively an ideal scenario to anticipate if the LSSR does not effectively break the chain of transmission of Covid-19 by stopping
the movement of people and goods through strict procedures and supported by strategic measures to ensure that regional quarantine is obeyed by the community. |
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|
32920095; Modeling COVID-19 pandemic using Bayesian analysis with application to
Slovene data |
Manevski, D, Ružić Gorenjec, et al |
Mathematical biosciences |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We propose a semiparametric framework for modeling the COVID-19 pandemic. The stochastic part of the framework is based
on Bayesian inference. The model is informed by the actual COVID-19 data and the current epidemiological findings about the disease. It is estimated that the proportion of infected people in Slovenia was among the lowest in Europe, that infection fatality
rate in Slovenia until the end of first wave was 1.56% and the proportion of unidentified cases was 88%. |
|
Maphosa, V, Dube, et al |
International Journal of Higher Education |
Public Health response| Interventions de santé publique |
Focusing through the lens of the (COVID-19) lockdown which was enforced on the 30th of March 2020, it became apparent
that students from rural resource-constrained educational institutions had to adapt to sustainable online learning platforms from traditional content delivery. Results revealed that WhatsApp can support 21st century learning through autonomous, collaborative
and learner centred education. |
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Strongyloides infection manifested during immunosuppressive therapy for SARS-CoV-2
pneumonia |
Marchese, V, Crosato, et al |
Infection |
Clinical data| Données cliniques |
We report the first case of S. stercoralis infection following an 11-day treatment with high-dose steroids and Tocilizumab
for severe COVID-19. Clinicians should be aware of the risk of strongyloidiasis as a complication of the treatment for severe COVID-19. |
|
Marchetti, F, Guiducci, et al |
Recenti progressi in medicina |
Clinical data| Données cliniques |
We report the descriptive experience of 14 cases of acro-ischemia in children and adolescents positive for COVID-19,
observed in the territorial area of Ravenna and Rimini. |
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Cloroquine and hydroxychloroquine: The Yin-yang of these drugs from a theoretical
study |
Martínez, A |
Journal of the Mexican Chemical Society |
Therapeutics| Thérapeutique |
The main objective of this report is to present the electronic properties of cloroquine and hydroxychloroquine that
might help explain the action mechanisms against virus. The idea that emerges from this study is that acid-base equilibrium is not the only criteria of importance to explain the action mechanism, but that the oxide-reduction balance may also help explain the
toxicity or effectiveness of these drugs. |
|
Martinez, M, Yang, et al |
Sensors (Switzerland) |
Public health interventions*| Interventions de santé publique |
In this paper, we present a system that helps blind people to maintain physical distance to other persons using a combination
of RGB and depth cameras. We use a real-time semantic segmentation algorithm on the RGB camera to detect where persons are and use the depth camera to assess the distance to them; then, we provide audio feedback through bone-conducting headphones if a person
is closer than 1.5 m. |
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Marvisi, M, Ferrozzi, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Here we summarize the clinical and radiological characteristics of 90 confirmed COVID-19 cases and analyze their role
in predicting the evolution of fibrosis. The evolution to pulmonary fibrosis is frequent in older males and patients with comorbidities and bone marrow involvement. |
|
|
Massey, BW, Jayathilake, et al |
Frontiers in Microbiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We determined the prevalence and type of a wide variety of respiratory pathogens in 12,075 United States subjects tested
for SARS-CoV-2 infection in March and April 2020. Infections with other respiratory pathogens, which on their own produce at least some SARS-CoV-2 symptoms including mortality, were present in both SARS-CoV-2 + and SARS-CoV-2- subjects. Among the co-pathogens
present in both subject groups were K. pneumoniae and M. catarrhalis which can produce serious respiratory illness on their own, Advanced age and nursing home status were associated with higher SARS-CoV-2 + and co-infection rates. |
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Matuschek, C, Fischer, et al |
Strahlentherapie und Onkologie |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The aim of this manuscript is to investigate the impact of radiation oncology institution (ROI) protocols and performance
on daily practice in the high-risk cancer patients during this pandemic. The results of the questionnaire showed that a noteworthy number of ROIs were able to complete treatment in SARS-CoV‑2 positive cancer patients, with only a short interruption. Most ROIs
reported a deep impact of SARS-CoV‑2 infections on their work routine. Modification and prioritization of treatment regimens and the application of protective measures preserved a well-functioning radiation oncology service and patient care. |
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Mayer, KP, Sturgill, et al |
Journal of medical case reports |
Clinical data| Données cliniques |
In this case report, we describe the trajectory of recovery of a young, healthy patient diagnosed with coronavirus
disease 2019 who developed acute respiratory distress syndrome. The purpose of this case report is to highlight the potential role of intensive care unit recovery or follow-up clinics for patients surviving acute hospitalization for coronavirus disease 2019. |
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Retrospective clinical evaluation of 4 lateral flow assays for the detection
of SARS-CoV-2 IgG |
McAulay, K, Bryan, et al |
Diagnostic microbiology and infectious disease |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
we evaluated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG detection with 4 lateral flow immunoassays
[LFIAs; 2 iterations from BTNX Inc. (n = 457) and 1 each from ACON Laboratories (n = 200) and SD BIOSENSOR (n = 155)]. All assays showed good concordance with the Abbott SARS-CoV-2 IgG assay at ≥14 days from symptom onset. These results suggest that LFIAs
may provide adequate results for rapid detection of SARS-CoV-2. |
|
McLoughlin, GM, McCarthy, et al |
J Urban Health |
Public Health response| Interventions de santé publique |
To prevent the exacerbation of health disparities, there is a need to understand the implementation of meal distribution
among large urban school districts during emergencies and to what degree these strategies provide equitable meal access. Our case study of four large urban school districts during the COVID-19 pandemic aims to address these knowledge gaps. Our findings can
support (1) ongoing efforts to address child food insecurity during the pandemic and (2) future meal provision through programs like the Summer Food Service Program and Seamless Summer Option. |
|
|
Mege, RA, Sumampouw, et al |
Walailak Journal of Science and Technology |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
This study aims to construct the phylogeny of the SARS corona virus that causes Covid-19 in various countries in the
world by using the SARS Covid-19 gene database from the NCBI GenBank. The results showed that the phylogeny trees formed were obtained by 2 main monophyletic groups. The presence of sequences from China in the 2 main monophyletic groups confirms that this
virus originated in the Chinese epicenter. |
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Multi-agent approach using lorawan devices: An airport case study |
Mendes, AS, Jiménez-Bravo, et al |
Electronics (Switzerland) |
Public Health response| Interventions de santé publique |
In this work, we present an Internet of Things (IoT) network to monitor the status of toilets and improve their maintenance.
This information is processed by a multi-agent system that detects possible anomalies and makes decisions accordingly. A case study in a real environment is developed in order to demonstrate the usefulness of the system. The results show that the proposed
method can be used to successfully manage and control airport toilets. |
|
Adjustment of population growth curve
applied to COVID-19 in Cuba |
Mendieta, JFM, Cortés Cortés, et al |
Revista Habanera de Ciencias Medicas |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We present predictions for the peak of COVID-19 cases, and the total number for some Cuban provinces and the whole
country. Predictive study of population growth curves and data from the first 52 days of the disease in the country are processed to estimate the models. The predictions suggest that the five provinces analyzed and Cuba show their peak of contagion in April. |
|
A case series of coinfection with SARS-CoV-2 and influenza virus in Louisiana |
Miatech, JL, Tarte, et al |
Respiratory Medicine Case Reports |
Clinical data| Données cliniques |
This case series of 4 patients identified at our single institution in Louisiana highlights the patient characteristics,
laboratory findings, and outcomes in patients with both Covid-19 and influenza infection. |
|
Miller, LE, Bhattacharyya, et al |
Data in Brief |
Epidemiology| Épidémiologie |
This article contains data on country-specific variability in Covid-19 prevalence, incidence, and case fatality rate
among the 238 countries globally. We extracted country-specific economic indicators from The World Bank Group Open Data database. All data were extracted on August 15, 2020. We developed consolidated data sets and calculated the country-specific point prevalence
and incidence of Covid-19 and associated deaths. |
|
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National all-cause mortality during the COVID-19 pandemic: a Danish registry-based
study |
Mills, EHA, Møller, et al |
Eur J Epidemiol |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
We examined national all-cause mortality comparing weeks 1–27 in 2020 and 2015–2019. We examined all-cause mortality
rates among all deaths recorded from 2015 to 2020 and among chronic conditions (cardiovascular (cardiac & circulatory), chronic pulmonary, chronic kidney disease, cancer, and diabetes), comparing each week in 2020 to weeks in 2015–2019. During the COVID-19
pandemic, due to timely lockdown measures, the mortality rate in Denmark has not increased compared to the mortality rates in the same period during 2015–2019. |
|
Evaluation of Boarding Methods Adapted for Social Distancing When Using Apron
Buses |
Milne, RJ, Delcea, et al |
IEEE Access |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
We conduct stochastic simulation experiments to assess nine adaptations of boarding methods according to four performance
metrics. Three of the metrics are related to the risk of the virus spreading to passengers during boarding. The fourth metric is the time to complete boarding of the two-door airplane when apron bus transport passengers to the airplane. The particular adaptation
to use depends on an airline’s relative preference for having short boarding times versus a reduced risk of later boarding passengers passing (and thereby possibly infecting) previously seated window seat passengers. |
|
Prediction the burden of COVID-19 in Iran: Application of disability-adjusted
life years (DALYs) |
Mirzaee, Negar, Barouni, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We used the extended form of the Susceptible-Exposed-Infected/Infectious-Recovered/Removed (SEIR) model to predict
new cases and number of deaths associated to COVID-19 in Iran. The total DALYs for COVID-19 in Iran predicted by our model will be 973 per 100,000 populations from January, 2020 to January, 2021. Our predictions of COVID-19 burden will be useful in determining
health priorities and to appropriately allocate resources to prepare for future outbreaks of COVID-19 and similar diseases. We hope this study will contribute to evidence-based health policy making in Iran. |
|
Mocchegiani, F, Baroni, et al |
Updates in Surgery |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated the clinical status of all currently alive liver transplant recipients (LTRs) transplanted in Ancona,
a single centre based in a high-incidence area, between January 1, 2005 and March 31, 2020. Among the 343 LTRs, 3 suffered from SARS-CoV-2 infection confirmed by nasopharyngeal swab and 36 were classified as “suspected cases” for COVID 19 symptoms with a negative
swab. Only one patient suffered from a severe infection. |
|
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Public responses to policy reversals:The case of mask usage in canada during COVID-19 |
Mohammed, A, Johnston, et al |
Canadian Public Policy |
Public Health response| Interventions de santé publique |
To examine how mask usage by Canadians changed in the months since the onset of the pandemic in Canada, we use data
from the Vox Pop Labs (2020) COVID-19 Monitor initiative, a rolling public opinion survey that has been fielded weekly since mid-March. We analyze the first 12 waves of the study, which were conducted between 20 March and 3 June and involved 27,040 respondents.
Despite the policy reversal on masks by Canadian public health officials, the survey data collected from the COVID-19 Monitor indicate that Canadians were responsive to changing guidance, self-reported usage rises from 5 percent in late March to 63 percent
by early June. Notably, the inflection point appears to take place in early April and corresponds with the issuance of revised guidance on masks by PHAC. |
|
32911957; Considerations in Management of Acute Otitis Media in the COVID-19 Era |
Mohan, S, Workman, et al |
Annals of Otology, Rhinology and Laryngology |
Clinical data| Données cliniques Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
To present the otologic findings of a patient with COVID-19 and complicated acute otitis media, evaluate for the presence
of SARS-CoV-2 in middle ear fluid, and assess whether suctioning of middle ear fluid may be aerosol- generating. Consistent with observations during endonasal suctioning, suctioning of middle ear fluid was not found to be aerosol or droplet generating. While
middle ear suctioning may not be aerosol-generating, the risk of coughing or prolonged close contact requires heightened precautions during otologic procedures in patients with suspected or confirmed COVID-19 |
|
Mohsen, A, Alarabi, et al |
F1000Research |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We created a simulation model to understand the effect of the starting day of community containment on the final outcome,
that is, the number of those infected, hospitalized and those that died, as we followed the dynamics of COVID-19 pandemic. Early implementation of community containment has a big impact on the final outcome of an outbreak. |
|
|
Psychological manifestations against
the epidemiological situation caused by COVID-19 |
Molina, YA, Solano, et al |
Revista Habanera de Ciencias Medicas |
Public Health response| Interventions de santé publique |
Psychological manifestations against the epidemiological situation caused by COVID-19 was explored by an observational
descriptive cross-sectional study of family medicine offices in Bayamo on April 2020. Anxiety as a state predominated in the majority of patients with high (30.96%) and medium (26.90%) levels; depression manifested as a state in the medium (36.54%) and high
(13.70%) and medium (12.20%) levels as a trait; 66.49% of the patients presented altered stress levels; 98.47% of the patients did not show a suicidal idea. There was no association between stress and anxiety (p= 0,90) and depression as a trait and state (p=
0,97). |
|
A flare of lupus nephritis in an 11-year-old sle patient with a mild COVID-19-associated
pneumonia |
Mousavi-Hasanzadeh, M, Sanatkar, et al |
Nephro-Urology Monthly |
Clinical data| Données cliniques |
Describe an 11-year-old female, previously known to have lupus nephritis, com-plaining of tachypnea, persistent fever,
low oxygen saturation (SaO2), and generalized edema with confirmed COVID-19 using spu-tum PCR testing on the first day of admission. |
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Pulmonary artery thrombi are co-located with opacifications in SARS-CoV2 induced
ARDS |
Mueller-Peltzer, K, Krauss, et al |
Respiratory medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Patients hospitalized for infection with SARS-CoV-2 typically present with pneumonia. The respiratory failure is frequently
complicated by pulmonary embolism in segmental pulmonary arteries. The distribution of pulmonary embolism in regard to lung parenchymal opacifications has not been investigated yet. Methods: All patients with COVID-19 treated at a medical intensive care unit
between March 8th and April 15th, 2020 undergoing computed tomography pulmonary angiography (CTPA) were included. All CTPA were assessed by two radiologists independently in respect to parenchymal changes and pulmonary embolism on a lung segment basis. Results:
Out of 22 patients with severe COVID-19 treated within the observed time period, 16 (age 60.4 ± 10.2 years, 6 female SAPS2 score 49.2 ± 13.9) underwent CT. A total of 288 lung segment were analyzed. Thrombi were detectable in 9/16 (56.3%) patients, with 4.4
± 2.9 segments occluded per patient and 40/288 (13.9%) segments affected in the whole cohort. Patients with thrombi had significantly worse segmental opacifications in CT (p < 0.05) and all thrombi were located in opacitated segments. There was no correlation
between d-dimer level and number of occluded segmental arteries. Conclusions: Thrombi in segmental pulmonary arteries are common in COVID-19 and are located in opacitated lung segments. This might suggest local clot formation. |
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32662399; Case Report: Novel coronavirus—a potential cause of acute pancreatitis? |
Muhammad Mashhood Ali Bokhari, S, Mahmood, et al |
American Journal of Tropical Medicine and Hygiene |
Clinical data| Données cliniques |
A 32-year-old medical practitioner presented to the emergency department with complaints of severe abdominal pain,
fever, and vomiting, 1 week after the diagnosis of COVID-19. This case highlights a possible association between COVID-19 and acute pancreatitis, and the need for clinicians to carefully evaluate patients presenting with gastrointestinal complaints during
the current pandemic. |
|
Mujica, RZ, Durán, et al |
Revista Habanera de Ciencias Medicas |
Public Health Priorities| Priorités de santé publique |
Characterize the scientific production on COVID-19 in Cuban medical journals during the first ninety days after the
start of the pandemic in Cuba. Over the period studied, the national scientific production in Cuban medical journals is low taking into account that the Letters to the Editor are not actual research articles. |
|
|
Muntean, PE, Neculcea, et al |
Archives of the Balkan Medical Union |
Clinical data| Données cliniques |
Describe a 49-year-old woman with fever later diagnosed with SARS-CoV-2 by RT-PCR. |
|
|
Munusamy, T, Karuppiah, et al |
World Neurosurg |
Healthcare Response | Réponse des soins de santé |
Virtual ward rounds using telemedicine via smart glasses on neurosurgical patients in critical care were feasible,
effective and widely accepted as an alternative to physical ward rounds during the COVID-19 pandemic |
|
|
New SARS-CoV-2 infection detected in an Italian pet cat by RT-qPCR from deep pharyngeal
swab |
Musso, N, Costantino, et al |
Pathogens |
Clinical data| Données cliniques zoonoses |
In this study, a domestic cat with clear clinical signs of pneumonia, confirmed by Rx imaging, was found to be infected
by SARS-CoV-2 using quantitative RT–qPCR from a nasal swab. |
|
Najafi-Ghezeljeh, T, Ashghali-Farahani, et al |
International Journal of Psychosocial Rehabilitation |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was sharing the experience of advocacy of the COVID-19 patient against other health employees.
An advocacy nurse is responsible to raise the awareness of the patient in taking appropriate decisions in treating and caring. Whatever the decision be, the nurse should advocate patient`s desire. Momentarily nursing of the clinical profession can play a key
role in therapy. |
|
|
Najim, RH, kadhim, et al |
Systematic Reviews in Pharmacy |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Covid-19 manifest multisystemic disease affect respiratory, gastrointestinal trac, nervous systems as well as other
body systems. baichemical parameters can help in diagnosis and follow up. Patients (n=130) were enrolled in the study ,65 patients of them diagnosed as having COVID-19 infection and other 65 participant were normal ,blood drawn from all of them and CBC,LDH,D-dimer,
CRP and ferritin were measured. Patients with positive PCR covid -19 infection with mean age (44.2±13.1) and 65 participant as control with negative RT-PCR with mean age (41.6±14.9).patients showing significant decrease in total WBc count and Lymphocytes (P-value:0.0001,0.0001)
and significant rise of LDH,D Dimer ,CRP and Ferritin levels. Biochemical parameters can be used as a predictor of COVID-19 infections rather than RT-PCR test or strengthen its results. |
|
|
Mathematical analysis of novel coronavirus (2019-nCov) delay pandemic model |
Naveed, M, Rafiq, et al |
Computers, Materials and Continua |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Mathematical analysis of corona virus model with time delay effects (the reproduction number of the delayed model)
are presented. The best uses of the delaying tactics, reduce the 2019-nCov rapidly. The most effective tools for the delay factors are quarantine, isolation, social distancing, immigration restrictions. However, according to the given data, application of
delaying tactics for approximately one hundred and thirteen days can lead to desired outcomes. |
|
Nesr, G, Koshy, et al |
British journal of haematology |
Clinical data| Données cliniques |
Report the case of a patient with Chronic lymphocytic leukaemia (CLL) who developed AIHA (autoimmune haemolytic anaemia)
, mostly secondary to a cold agglutinin, and a marked increase in lymphocyte count, in the context of worsening COVID‐19. |
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COVID-19 and digital technology: Mobile applications available for download
in smartphones |
Neto, NMG, de Moura Sá, et al |
Texto e Contexto Enfermagem |
Public Health response| Interventions de santé publique |
Describe Covid-19 mobile applications available for download on smartphones. 86.6% were developed in 2020, 98.1% were
free, and 94.2% did not have accessibility for people with disabilities; 32.7% applications were in English. The majority of applications were on “case monitoring” and “symptoms, prevention, and care”. There was an association between the target audience
and the subtheme of “symptoms, prevention, and care”, and between patient monitoring and professional training. |
|
Ng, BH, Abeed, et al |
Medical Journal of Malaysia |
Healthcare Response | Réponse des soins de santé |
Examined the experience of HCWs who were quarantined following a close unprotected contact with a COVID-19 positive
colleague and explore the psychological impact especially as the timing of the quarantine coincided with the Eid (annual Muslim festival) celebration in Malaysia. HCWs undergoing contact swabbing and quarantine are vulnerable to depression, anxiety and stress.
The ability of the HCW to adequately home quarantine should not be taken for granted. Psychological support should be offered to HCWs who are positive contacts. |
|
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Nicolai, L, Leunig, et al |
Circulation |
Clinical data| Données cliniques Immunology | Immunologie |
The investigators performed histopathologic assessment of autopsy cases, surface marker–based phenotyping of neutrophils
and platelets, and functional assays for platelet, neutrophil functions, and coagulation tests. The analysis provides evidence that neutrophils, immunogenic platelets, and a dysregulated coagulation cascade cooperate to propagate immunothrombotic tissue injury
in COVID-19, as shown in autopsy specimens and the blood of patients. |
|
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The effect of immune molecules in protection against COVID 19 |
Njum, AA, Hassan, et al |
International Journal of Psychosocial Rehabilitation |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Investigation attempts to estimate the manifestation of stimulated indicators on pB L (IL-8 & TNF-α by ELISA) and the
manifestation of CD45 & CD74 in patients infected with COVID19. Acute covid 19 patient sera were high for IL-8 & TNF-α, and moderate cases of disease expressed large increases in IL-8. Activated markers study revealed high expression of CD74 & CD45 in covid
19 patients as compared with healthy normal groups, |
|
32921751; Elevated transaminases in a COVID-19 positive patient at term of gestation:
A case report |
Nkeih, C, Sisti, et al |
Acta Biomedica |
Clinical data| Données cliniques |
Present the case of a 29 years-old patient at 38 weeks of gestation COVID-19 positive with elevated transaminases. |
|
COVID-19 outbreak: Insights about teaching tasks in a chemical engineering laboratory |
Nogales-Delgado, S, Suero, et al |
Education Sciences |
Public Health response| Interventions de santé publique |
The aim of this work was to explain our own experience during the COVID-19 outbreak in a chemical engineering laboratory
at the University of Extremadura, concerning the university teaching and the final degree project follow-up, whose method of teaching was active and participatory, based on constructivism and focused on the student as the center of the learning process. Thus,
the confinement affected both the teachers and students differently, depending on the degree of completion of their main tasks and their previous skills with computing and virtual tools, among other factors. The existence of an operating virtual campus and
an online library has made the transition to total e-learning and telework easier for teachers and students. |
|
Obeid, JS, Davis, et al |
Journal of the American Medical Informatics Association : JAMIA |
Healthcare Response | Réponse des soins de santé |
In an effort to improve the efficiency of computer algorithms applied to screening for coronavirus disease 2019 (COVID-19)
testing, we used natural language processing and artificial intelligence-based methods with unstructured patient data collected through telehealth visits. Text analytics revealed that concepts such as smell and taste were more prevalent than expected in patients
testing positive. As a result, screening algorithms were adapted to include these symptoms. The deep learning model yielded an area under the receiver-operating characteristic curve of 0.729 for predicting positive results and was subsequently applied to prioritize
testing appointment scheduling. Informatics tools such as natural language processing and artificial intelligence methods can have significant clinical impacts when applied to data streams early in the development of clinical systems for outbreak response. |
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Ochoa-Rosales, C, González-Jaramillo, et al |
Revista de Salud Publica |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Objective: to model disease progression, healthcare demand and case fatality rate attributed to COVID-19 pandemic that
may occur in Chile in 1-month time, by simulating different scenarios according to diverse mitigation measures hypothetically implemented. If no mitigation measures were applied (R0=2.5), by May 25, Chile would have 2 019 775 cases and 15 068 deaths. If mitigations
measures were implemented to decrease R0 to 1.5 (early detection of cases, quarantine, social distancing of elderly), the number of cases and deaths would importantly decrease. Nonetheless, the demand for in-hospital care including intensive care would exceed
the available resources. Our age-specific analysis showed that population over 60 years are at higher risk of needing intensive care and death. |
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32804682; Vitamin D Supplementation in COVID-19 Patients: A Clinical Case Series |
Ohaegbulam, KC, Swalih, et al |
American Journal of Therapeutics |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We report 4 vitamin D deficient patients diagnosed with COVID-19 in April 2020 who were provided with either cholecalciferol
of 1000 IU daily (standard dose) or ergocalciferol 50,000 IU daily for 5 days (high dose) as part of supplementation. Patients that received a high dose of vitamin D supplementation achieved normalization of vitamin D levels and improved clinical recovery
evidenced by shorter lengths of stay, lower oxygen requirements, and a reduction in inflammatory marker status. |
|
Oikonomou, E, Aznaouridis, et al |
Public health |
Healthcare Response | Réponse des soins de santé |
investigate trends of cardiac disease admissions during the outbreak of the pandemic in Greece and possible associations
with the applied restrictive measures. Data analysis show significant drops in cardiology visits and admissions during the COVID-19 outbreak time period. Whether this results from restrictive measures or depicts a true reduction of cardiac disease cases warrants
further investigation. |
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Okar, L, Ali, et al |
Clinical Case Reports |
Clinical data| Données cliniques |
Case report 25 year old female |
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The safety of paediatric surgery between COVID-19 surges: an observational study |
Okonkwo, INC, Howie, et al |
Anaesthesia |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
Study presents outcome data from a children’s hospital in north‐west England, the region with the highest prevalence
of COVID‐19 in England. There were no differences in the incidence of SARS‐CoV‐2 amongst children and young people who had or hadn’t isolated for 14 days (p > 0.99). One out of 685 (0.1%) children who had surgery re‐presented to hospital with symptoms potentially
consistent with SARS‐CoV‐2 within 14 days of surgery. Outcomes were similar to those in the same time period in 2019 for length of stay (p = 1.0); unplanned critical care admissions (p = 0.59); and 14‐day hospital readmission (p = 0.17). However, the current
cohort were younger (p = 0.037); of increased complexity (p < 0.001) and underwent more complex surgery (p < 0.001). |
|
O'Leary, F, Pobre, et al |
Emerg Med Australas |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
Estimate the Personal Protective Equipment (PPE) required in a Paediatric Emergency Department during the COVID‐19
pandemic comparing the use per patient to use per patient zone, based on the NSW Clinical Excellence Commission (CEC) guidelines in place at the time of the study. This study demonstrated the considerable requirement for PPE in a Paediatric ED, which varies
according to presentation type and the background prevalence of COVID‐19 in the community. |
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Outcomes of patients with confirmed SARS-CoV-2 infection undergoing anesthesia:
A pilot study |
Oliveira, F, Silva, et al |
Journal of clinical anesthesia |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Presents the perioperative management and 60-day morbidity and mortality of patients with confirmed SARS-CoV-2 undergoing
anesthetic procedures. The study highlights surgical stress can decrease cellular immunity, which is important for the control of SARS-CoV-2 infection. The majority of patients positive for SARS-CoV-2 infection in the preoperative period was asymptomatic.
Some asymptomatic patients before procedure developed symptoms in the postoperative period, and there is a difference in mortality risk between having versus not having pre-operative symptoms. |
|
Oliveira, LM, Zanatta, et al |
Brazilian oral research |
Public Health response| Interventions de santé publique |
Infodemiological study evaluate whether the COVID-19 outbreak influenced the volume of content related to the dental
treatment needs of Brazilian Twitter users, and summarize trends and perceptions of treatment needed. Findings from the word cloud and content analysis suggest that dental pain, related or not to the third molar, and problems with orthodontic appliances
were the topics most commonly related to dental treatment needs discussed during the COVID-19 outbreak, mainly conveying anxiety and distress. The volume of tweets related to dental treatment needs posted by Brazilian users increased during the COVID-19 outbreak
and self-reported pain and urgencies were the most popular topics. |
|
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Oliver, N, Barber, et al |
Journal of medical Internet research |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
Assess the situation and perception of the Spanish population in four key areas related to the COVID-19 pandemic: social
contact behavior during confinement, personal economic impact, labor situation, and health status. Regarding social behavior during confinement, participants mainly left their homes to satisfy basic needs. We found several statistically significant differences
in social behavior across genders and age groups. The population's willingness to comply with the confinement measures is evident. From the survey answers, we identified a significant adverse economic impact of the pandemic on those working in small businesses
and a negative correlation between economic damage and willingness to stay in confinement. The survey revealed that close contacts play an important role in the transmission of the disease, and 28% of the participants lacked the necessary resources to properly
isolate themselves. We also identified a significant lack of testing, with only 1% of the population tested and 6% of respondents unable to be tested despite their doctor's recommendation. We developed a generalized linear model to identify the variables that
were correlated with a positive SARS-CoV-2 test result; estimated an average of 5% for SARS-CoV-2 prevalence in the Spanish population. . |
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Concurrent tonic pupil and trochlear nerve palsy in COVID-19 |
Ordás, CM, Villacieros-Álvarez, et al |
Journal of neurovirology |
Clinical data| Données cliniques |
Report a case of concurrent tonic pupil and trochlear nerve palsy in a 62-year-old man . |
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O'Reilly, GM, Mitchell, et al |
Emerg Med Australas |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to describe the epidemiology and clinical features of patients presenting to an Australian
emergency department (ED) with suspected and confirmed COVID‐19. Among positive cases, two (4%) received mechanical ventilation during their hospital admission compared to 45 (2%) of the SARS‐CoV‐2 negative patients (OR 1.7 [95% CI: 0.4–7.3], p = 0.47). Two
(4%) SARS‐CoV‐2 positive patients died in hospital compared to 46 (2%) of the SARS‐CoV‐2 negative patients (OR 1.7 [0.4–7.1] p = 0.49). Strong clinical predictors of a positive result included self‐reported fever, non‐smoking status, bilateral infiltrates
on CXR, and absence of a leucocytosis on first ED blood tests (p < 0.05). Presence of SARS‐CoV‐2 on nasopharyngeal swab was not associated with death or mechanical ventilation. |
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Orth-Höller, D, Eigentler, et al |
J Infect |
Immunology | Immunologie |
A follow-up study to the anti-SARS-CoV-2-antibody kinetics in a well-characterized cohort of 20 mild to moderately
diseased office-based physicians with PCR-confirmed infection, during the first four weeks after symptom onset. The authors present data on longitudinal profiles of different antibody immunoglobulin classes (IgM, IgA, IgG) using tests with different antigens
as well as neutralizing titers in the same cohort four months after symptom onset. Observations indicate RBD- and NCP-specific IgM as well as S1-specific IgA levels significantly decrease within four months after disease onset, with RBD-specific IgM and S1-specific
IgA still being detectable at this time point. |
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Oterino Serrano, C, Alonso, et al |
European Journal of Radiology |
Clinical data| Données cliniques |
Establish the most common CXR patterns in children with COVID-19, evaluate interobserver correlation and to discuss
the role of imaging techniques in the management of children. |
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Ozamiz-Etxebarria, N, Santa María, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
An intervention was carried out on university voluntary participants in order to help lower their anxiety levels. Specifically,
a telematic workshop was implemented to teach emotional literacy and relaxation techniques combined with the practice of the techniques in an autonomous manner. Anxiety measurements were taken before and after the workshop using the Generalized Anxiety Disorder
– 7 (GAD-7) scale. The results show that Jacobson’s progressive relaxation techniques, Schultz’s autogenic training, abdominal relaxations, and visualizations are effective in lowering the anxiety levels of university students as an alternative to pharmacotherapy. |
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32901715; Analysis of Dentistry YouTube Videos Related To COVID-19 |
Ozdede, M, Peker, et al |
Brazilian dental journal |
Healthcare Response | Réponse des soins de santé |
This study aimed to analyze the videos available on YouTube related to dentistry and the novel coronavirus (COVID-19),
as there is no such analysis in the existing literature. The analyzed videos were viewed 375,000 times and totaled 20 h of content. Most videos were uploaded by dentists (45.7%), originated from the United States (79.3%), and contained information targeted
towards patients (48.3%). Nearly half of the videos (47.4%) were moderately useful. For the usefulness of the videos, statistically significant differences were found for all indices as well as total VIQI scores. A comparison of the indices according to the
relevance of the videos showed statistically significant differences in the videos' information and precision indices and total VIQI scores. The results of this study showed that dentistry YouTube videos related to COVID-19 had high view numbers; however,
the videos were generally moderate in quality and usefulness. |
|
Pacheco, T, Coulombe, et al |
International Journal of Wellbeing |
Public Health response| Interventions de santé publique |
1,073 Canadian workers working full-/part-time or who were temporarily laid off completed an online survey, including
measures of wellbeing at work or in general, job security and potential resilience levers (workplace disaster preparedness, policy, social capital). Multiple regression findings highlight that marginalized workers (e.g., women, migrants, people facing financial
hardships) reported lower job security, and having temporarily lost one’s job was negatively associated with job security. Low job security was related to lower scores across measures of wellbeing. Distress was high in the sample. Workplace disaster preparedness,
policy and social capital were associated with higher wellbeing. The effects of these resilience levers tended to be stronger at higher job security levels. |
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|
Pan, D, Sze, et al |
J Infect |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Shortly after a confirmed diagnosis of COVID-19 using the local diagnostic AusDiagnostics (Ausdiagnostics UK Ltd.,
Chesham, England) SARS-CoV-2 PCR test,3 each participant volunteered to provide serial self-collected swabs from the nasopharynx (NPS, 1 swab), just inside the soft part of the nose (NS, 1 swab), the oropharynx (OPS, 1 swab), inside the cheek (CS, 1 swab).
In addition, we also decided to check for the presence of SARS-CoV-2 in the conjunctiva (CJS, 1 swab for both eyes). From 17th April to 5th May 2020, a total of 105 swabs were collected from three participants. All three participants were PCR negative for
SARS-CoV-2 on the final swabs taken on 5th May 2020. Patient 1 (mild COVID-19) only had positive PCR results from the NPS and NS, with negative PCR results from the NS after day 8. Patient 2 had positive PCR results from all sites except for the conjunctiva,
with the lowest cycle threshold (Ct) value (i.e. the highest viral load) in the NPS, followed by the OPS, NS and CS. Patient 3 had positive PCR values from all sites; with the lowest Ct value (highest viral load) in the NPS followed by NS, CS, OPS and CJS.
For all three participants, Ct values appeared to increase (i.e. the viral loads decreased) over time. self-swabbing from these various URT sites is an effective and sensitive way to collect diagnostic samples, as found elsewhere. we conclude that for symptomatic
patients, it is difficult to obtain a ‘false negative’ result on NPS, OPS, NS or CS samples, if sampled early (within 5 days) post-symptom onset, even if the swab was ‘poorly’ taken. |
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Pan, J, Yao, et al |
Science of the Total Environment |
Epidemiology| Épidémiologie |
We collected daily numbers of COVID-19 cases in 202 locations in 8 countries. We matched meteorological data from the
NOAA National Centers for Environmental Information. Temperature did not exhibit significant association with R0 of COVID-19 (meta p = 0.446). Also, relative humidity (meta p = 0.215), wind speed (meta p = 0.986), and ultraviolet (UV) radiation (meta p = 0.491)
were not significantly associated with R0 either. |
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Pan, S, Jung, et al |
Sustainability (Switzerland) |
Public health interventions*| Interventions de santé publique |
This study compared the surface air quality monitoring data from the United States Environmental Protection Agency
(U.S. EPA)'s AirNow network during the period 20 March-5 May in 2020 to those in 2015-2019 from the Air Quality System (AQS) network over the state of California. The results indicated changes in fine particulate matter (PM2.5) of-2.04 ± 1.57 μg m-3 and ozone
of-3.07 ± 2.86 ppb. If the air quality improvements persist over a year, it could potentially lead to 3970-8900 prevented premature deaths annually (note: the estimates of prevented premature deaths have large uncertainties). Public transit demand showed dramatic
declines (~80%). The pandemic provides an opportunity to exhibit how substantially human behavior could impact on air quality. |
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Paparella, D, Colucci, et al |
Thrombosis research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Out of 98 patients admitted to a dedicated COVID-19 ICU at the University Hospital of Bari with diagnosis of ARDS,
18 consecutive patients (from March 18 to May 12, 2020) were included in a thorough evaluation over time aiming to assess the changes of several reliable clotting variables in order to determine the nature of the coagulopathy associated with COVID-19 and its
relationship with inflammation. Our data show that patients with COVID-19 display marked alterations of the coagulation system, which, however, are not compatible with a consumption coagulopathy typical of DIC. we found that the main change in COVID-19 patients
is the rise in D-dimer and fibrinogen levels. On the contrary, platelets, PT and PTT were within the normal range and their trajectories over the whole follow-up did not show any sign of consumption. |
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Park, JH, Lee, et al |
Frontiers in Immunology |
Clinical data| Données cliniques Coronavirology| Coronavirologie Immunology | Immunologie |
In this study, we re-analyzed published scRNA-seq data of COVID-19 patient bronchoalveolar lavage fluid to further
classify and compare immunological features according to the patient’s disease severity. we suggest that severe COVID-19 symptoms may be determined by differential expression of glucocorticoid receptors and neutrophils. |
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Park, S, Cha, et al |
Korean Journal of Policy Studies |
Epidemiology| Épidémiologie |
This study explores the demographic and environmental factors affecting the spread and mortality rate of COVID-19 in
countries around the world. We found that countries with a higher proportion of people over 65 had a higher rate of confirmed positive cases, a higher mortality rate, and a higher case fatality rate. We also found that there was a positive and significant
statistical correlation between the number of foreign migrants in a country and the rate of confirmed positive COVID19 cases and the number of deaths but an inverse relationship between this variable and the case fatality rate. We found a negative relationship
between the number of hospital beds and mortality and case fatality rate while but a positive relationship between the level of nitrogen oxides in the environment and the rate of confirmed positive cases, the mortality rate, and the case fatality rate, although
there was no such relationship for ultrafine dust. |
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32921739; Oncolytic effect of SARS-CoV2 in a patient with NK lymphoma |
Pasin, F, Mascalchi Calveri, et al |
Acta bio-medica : Atenei Parmensis |
Clinical data| Données cliniques |
In this case, we notice a dramatic transient reduction in plasmatic EBV-DNA viral copies during Covid-19 pneumonia
other than NK clonal cells reduction, and after the infection resolution we described a lymphoma relapse as well as EBV-DNA increase and the rising in NK clonal cells count. |
|
Péré, H, Wack, et al |
Journal of Clinical Virology |
Epidemiology| Épidémiologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
From May 2nd to 26th June 2020, we tested with the Abbott SARS-CoV-2 IgG assay 3569 staff HCWs (female, 74.8 %; median
age, 39.6 years) in the hospital department of occupational medicine, on a voluntary basis. SARS-CoV-2 IgG antibodies were detected in 423 (11.9%) HCWs. A. A total of 90 (2.5 %) HCWs with equivocal Abbott index values were further retested with Beckman Coulter
IgG assay: 70 were SARS-CoV-2 IgG-negative, 6 showed equivocal results, and 14 (15.5 %; 0.4 % of HCWs) were SARS-CoV-2 IgG-positive. The combination strategy of two SARS-CoV-2 IgG assays having different targets in series with final interpretation given by
the second test was used to address the issues of HCWs with equivocal results by the first test. In our series, such strategy made possible to recover 14 sera having index values in the Abbott equivocal zone. |
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Phankokkruad, M |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This work intent to develop the CNN model by the process of transfer learning. The models will be created from the
three pre-trained models include Xception, VGG16, and Inception-Resnet-V2 model. Then, these newly proposed models will be applied to detect COVID-19 pneumonia from the X-ray image dataset. The proposed models enhance to diagnose the chest X-ray images of
patients who have pneumonia by COVID-19. Since the existing COVID-19 X-ray dataset has a small number of images containing 323 images, this work uses the data augmentation techniques to increase the virtual number of images. The results reveal that the proposed
models have performed the classification task for detecting pneumonia. The proposed model achieved an accuracy level of Xception, VGG16, and Inception-Resnet-V2 is 97.19%, 95.42% and 93.87%, respectively. |
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Philip, K, Cumella, et al |
BMJ open |
Public Health response| Interventions de santé publique |
OBJECTIVES: To assess the experience of people with long-term respiratory conditions regarding the impact of measures
to reduce risk of COVID-19. PARTICIPANTS: 9515 people with self-reported long-term respiratory conditions. 45% reported disruptions to care, including cancellations of appointments, investigations, pulmonary rehabilitation, treatment and monitoring. Other
practical impacts such as difficulty accessing healthcare services for other issues and getting basic necessities such as food were also common. 36% did not use online prescriptions, and 54% had not accessed online inhaler technique videos. Psychosocial impacts
including anxiety, loneliness and concerns about personal health and family were prevalent. 81% reported engaging in physical activity. Among the 11% who were smokers, 48% reported they were planning to quit smoking because of COVID-19. |
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Immune responses to SARS-CoV-2 infection in hospitalized
pediatric and adult patients |
Pierce, CA, Preston-Hurlburt, et al |
Sci Transl Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
We compared cytokine, humoral, and cellular immune responses in pediatric (children and youth, age < 24 years) (n=65)
and adult (n=60) patients with COVID-19 at a metropolitan hospital system in New York City. The pediatric patients had a shorter length of stay, decreased requirement for mechanical ventilation and lower mortality compared to adults. The serum concentrations
of IL-17A and IFN-γ, but not TNF-α or IL-6, were inversely related to age. Adults mounted a more robust T cell response to the viral spike protein compared to pediatric patients as evidenced by increased expression of CD25+ on CD4+ T cells and the frequency
of IFN-γ+CD4+ T cells. Moreover, serum neutralizing antibody titers and antibody-dependent cellular phagocytosis were higher in adults compared to pediatric COVID-19 patients. The neutralizing antibody titer correlated positively with age and negatively with
IL-17A and IFN-γ serum concentrations. There were no differences in anti-spike protein antibody titers to other human coronaviruses. |
|
Piro, A, Magnocavallo, et al |
J Cardiovasc Electrophysiol |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
METHODS: Starting March 1st, 332 patients were introduced to a RM program during the Italian lockdown in order to limit
the risk of in-hospital exposure to Severe Acute Respiratory Syndrome-Coronavirus-2. Patients were categorized into two groups based on the modality of RM delivery home (n=229) vs office (n= 103) delivered]. The study aimed at assessing the efficacy of the
new follow-up protocol, assessed as mean RM Activation Time (AT) and need for technical support. Results: Activation Time (AT) time was <48 hours in 93% of patients and 7% of them required further technical support. Despite a higher number of trans‐telephonic
technical support in home‐delivered Remote monitoring (RM) group, mean AT was similar between groups (1.33±0.83 days in home‐delivered vs 1.28±0.81 days in office‐delivered patients; p=0.60). Twenty‐eight (2.5%) urgent/emergent in‐person examinations were
required. A high degree of patient satisfaction was reached in both groups whereas anxiety status was higher in office‐delivered group. |
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|
Pitakbut, T |
Walailak Journal of Science and Technology |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study was conducted by applying the advanced techniques in both computational biology and chemistry to evaluate
the anti-SARS-CoV-2 potential of andrographolide. In this study, andrographolide was tested against two key enzymes of SAR-CoV-2 namely 3C main proteinase and RNA dependent RNA polymerase. The result here indicated that andrographolide could only inhibit the
SARS-CoV-2 3C main proteinase as strong as lopinavir (the standard medicine), which has been recommended as the drug of choice to treat SARS-CoV-2 patient. |
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Impact of vitamin d deficiency on covid-19—a prospective analysis from the covild registry |
Pizzini, A, Aichner, et al |
Nutrients |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
we aimed to investigate associations of Vitamin D (VITD) status to disease presentation within the CovILD registry.
A total of 109 patients were included in the analysis (60% males, 40% females), aged 58 ± 14 years. Eight weeks after the onset of COVID-19, a high proportion of patients presented with impaired VITD metabolism and elevated parathyroid hormone (PTH) levels.
PTH concentrations were increased in patients who needed intensive care unit (ICU) treatment, while VITD levels were not significantly different between disease severity groups. Low VITD levels at disease onset or at eight-week follow-up were not related to
persistent symptom burden, lung function impairment, ongoing inflammation, or more severe CT abnormalities. VITD deficiency is frequent among COVID-19 patients but not associated with disease outcomes. However, individuals with severe disease display a disturbed
parathyroid-vitamin-D axis within their recovery phase. |
|
Podvorica, G, Rrustemi, et al |
Journal of Environmental Management and Tourism |
Public Health response| Interventions de santé publique Economics | Économie |
The study employs a survey of 500 random respondents. A multivariate analysis indicated that scores of planning summer
vacations were significantly associated with the present strict prevention behavior measures against COVID-19 indicating the existence of sufficient motivation for future behavior intentions. In contrasts, monthly income is not a predictor for planning summer
vacations. Finally, the correlation is positive between respondent’s previous experience to touristic destinations in Albania last year and planning summer vacations this year. |
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|
Poggiali, E, Vercelli, et al |
Acta bio-medica : Atenei Parmensis |
Healthcare Response | Réponse des soins de santé |
Here we report our experience in the first month of the Italian epidemic. We strongly recommend clinicians to maintain
a high index of suspicion for COVID-19, regardless of the persistence negativity of NP swabs, and not to delay the initiation of therapy in presence of typical clinical, radiological and laboratory findings of COVID-19. |
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|
Popovic, M, Minceva, et al |
Heliyon |
Coronavirology| Coronavirologie |
RNA and protein sequences obtained from databases were used to count the number of atoms of each element in the virions
of SARS, MERS and SARS-CoV-2. The number of protein copies and carbohydrate composition were taken from the literature. The number of lipid molecules was estimated from the envelope surface area. Based on elemental composition, growth equations were balanced,
and thermodynamic properties of the viruses were determined using Patel-Erickson and Battley equations. Elemental and molecular compositions of SARS, MERS and SARS-CoV-2 were found, as well as their standard thermodynamic properties of formation and growth.
Standard Gibbs energy of growth of virus nucleocapsids was found to be significantly more negative than that of their host tissue. The ratio of Gibbs energies of growth of virus nucleocapsids and host cell is greater than unity. The more negative Gibbs energy
of growth of viruses implies that virus multiplication has a greater driving force than synthesis of host cell components, giving a physical explanation of why viruses are able to hijack their host cell's metabolism. |
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|
The Adaptation of Pediatric Exercise Testing Programs to the Coronavirus/COVID-19
Pandemic |
Powell, AW, Mays, et al |
World J Pediatr Congenit Heart Surg |
Healthcare Response | Réponse des soins de santé |
A web-based survey was designed and sent to pediatric exercise testing laboratories in the United States and Canada.
Questions were designed to understand the initial and ongoing adaptations made by pediatric exercise testing laboratories in response to COVID-19. Results were analyzed as frequency data. There were responses from 42% (35/85) of programs, with 68% (23/34)
of laboratories discontinuing all exercise testing. Of the 23 programs that discontinued testing, 15 (65%) are actively working on triage plans to reopen the exercise laboratory. Personal protective equipment use include gloves (96%; 25/26), surgical masks
(88%; 23/26), N-95 masks (54%; 14/26), face shields (69%; 18/26), and gowns (62%; 16/26). Approximately 47% (15/32) of programs that typically acquire metabolic measurements reported either ceasing or modifying metabolic measurements during COVID-19. Additionally,
62% (16/26) of the programs that previously obtained pulmonary function testing reported either ceasing or modifying pulmonary function testing. Almost 60% of respondents expressed a desire for additional guidance on exercise laboratory management during COVID-19. |
|
Prater, C, Tepe, et al |
Journal of Primary Care and Community Health |
Healthcare Response | Réponse des soins de santé |
We designed a prospective observational pilot study at a community health center to measure the effectiveness of two
interventions among an underserved population: a multidisciplinary pain team and chiropractic care. Thirty-five individuals completed baseline and follow-up Pain Disability Questionnaire (PDQ) from August 2018 to May 2020. Overall, the mean baseline PDQ was
92.4 +/− 6.1 and the mean follow-up PDQ was 81.9 +/− 7.7, resulting in a mean improvement of −10.6 (95% CI 1.2 - −22.3, P = .08). Participants in the chiropractic team (mean change −25.0, P = .01) and those completing the study before COVID-19 (mean change
= −22.6, P < .01) were found to have significantly greater improvement at follow-up. |
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Prathumwan, D, Trachoo, et al |
Symmetry |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
A mathematical model for forecasting the transmission of the COVID-19 outbreak is proposed to investigate the effects
of quarantined and hospitalized individuals. We analyze the proposed model by considering the existence and the positivity of the solution. Then, the basic reproduction number (R0)-the expected number of secondary cases produced by a single infection in a
completely susceptible population-is computed by using the next-generation matrix to carry out the stability of disease-free equilibrium and endemic equilibrium. The results show that the disease-free equilibrium is locally asymptotically stable if R0 < 1,
and the endemic equilibrium is locally asymptotically stable if R0 > 1 |
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Prilutskaya, MV, Grjibovski, et al |
Ekologiya Cheloveka (Human Ecology) |
Public Health response| Interventions de santé publique |
Altogether, 228 students and staff of the Pavlodar branch of the Semey Medical University participated in an online
survey. In total, 30.3 % of respondents experienced substantial difficulties in maintaining self-isolation/social distancing. Their proportion was higher among those frequently watching, reading or listening to news about COVID-19 (41.7 % vs. 20.0 %, р < 0.001),
and getting the information from online bloggers (42.9 % vs. 26.8 %, р = 0.03). The psychological stress was reported by 92.7 % of the respondents. Those who experienced the difficulties with self-isolation/social distancing were more likely to feel excessive
stress due to mobility restrictions (30.4 % vs. 6.9 %, p = 0.001), limited interpersonal communication (37.7 % vs. 17.0 %, p < 0.001), distance education (26.1 % vs. 11.3 %, p = 0.006), the suspension/reduction of clinical practice (33.3 % vs. 20.1 %, p =
0.044) than the others. That group with the difficulties had a higher proportion of anxiety (26.1 % vs. 11.9 %, p = 0.008) and depression symptoms (40.6 % vs. 22.0 %, p = 0.004). Positive correlations were observed between the severity of the perceived difficulties
and the frequency of watching, reading or listening to COVID-19 news (r = 0.26 p < 0.001). The difficulties correlated with symptoms of anxiety (r = 0.36, p < 0.001) and depression (r = 0.25, p < 0.001), stress due to mobility restrictions (r = 0.50, p < 0.001),
limited interpersonal communication (r = 0.39, p < 0.001), and distance education (r = 0.31, p < 0.001). |
|
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Probst, T, Budimir, et al |
Journal of affective disorders |
Public Health response| Interventions de santé publique |
In the current study, we explored changes of depression in vs. after lockdown and whether stress and loneliness during
the lockdown affect subsequent depression after the COVID-19 lockdown in Austria. A repeated measures online survey was performed by Qualtrics with the first wave during the lockdown from 10th to 30th of April 2020 and the second wave after the lockdown from
11th to 22nd of June 2020. The first wave comprised 1,005 individuals (representative for age, gender, education, region) and 445 of them took part in the second wave. More individuals changed from not depressed in lockdown to depressed after lockdown (n=39,
8.8%) as compared to from depressed in lockdown to not depressed after lockdown (n=21, 4.7%). Higher stress combined with higher loneliness in lockdown had the most detrimental effect on depression after lockdown. |
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Pullen, MF, Skipper, et al |
Open Forum Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques RCT |
We recruited participants nationwide for a randomized clinical trial. We categorized participants into 3 groups: (1)
those with confirmed SARS-CoV-2 infection, (2) those with probable SARS-CoV-2 infection (pending test or not tested but with a confirmed COVID-19 contact), and (3) those with possible SARS-CoV-2 infection (pending test or not tested and with a contact for
whom testing was pending or not performed). Among 1252 symptomatic persons screened, 316 had confirmed, 393 had probable, and 543 had possible SARS-CoV-2 infection. In early infection, those with confirmed and probable SARS-CoV-2 infection shared similar symptom
profiles, with fever most likely in confirmed cases (P = .002). Confirmed cases did not show any statistically significant differences compared with unconfirmed cases in symptom frequency at any time point. The most commonly reported symptoms in those with
confirmed infection were cough (82%), fever (67%), fatigue (62%), and headache (60%), with only 52% reporting both fever and cough. |
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Qin, B, Li, et al |
Sensors (Switzerland) |
Public health interventions*| Interventions de santé publique |
In this study, we develop a new facemask-wearing condition identification method by combining image super-resolution
and classification networks (SRCNet), which quantifies a three-category classification problem based on unconstrained 2D facial images. the proposed SRCNet achieved 98.70% accuracy and outperformed traditional end-to-end image classification methods using
deep learning without image super-resolution by over 1.5% in kappa. |
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32920578; SARS-CoV-2 and Dengue virus Co-infection. A Case Report |
Radisic, MV, Piro, et al |
Le infezioni in medicina |
Clinical data| Données cliniques |
Coinfection of SARS-CoV-2 and dengue virus has not been previously reported. We report a confirmed case with favourable
outcome, but whether the occurrence of simultaneous infections may alter the usual clinical course of each infection is still unknown. |
|
Rahman, MR, Islam, et al |
Modeling Earth Systems and Environment |
Epidemiology| Épidémiologie |
Hence, this study was an attempt to in-depth assess and analyze the COVID-19 outbreak and transmission dynamics through
space and time in Bangladesh using 154 day real-time epidemiological data series. In Bangladesh, the status of the pandemic COVID-19 still is in exposure level. Disease transmitted at a high rate (20.37%), and doubling time of the cases were 11 days (latest
week of the study period). The fatality rate was comparatively low (1.3%), and the recovery rate was about 57.50%. Geospatial analysis exhibits the disease propagates from the central parts. |
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Rajdev, K, Farr, et al |
Journal of Investigative Medicine High Impact Case Reports |
Clinical data| Données cliniques |
We present a case of a 32-year-old COVID-19 positive male with a history of diabetes mellitus who was intubated for
severe acute respiratory distress syndrome (ARDS). The patient’s hypoxemia failed to improve despite positive pressure ventilation, prone positioning, and use of neuromuscular blockade for ventilator asynchrony. He was evaluated by a multidisciplinary team
for considering extracorporeal membrane oxygenation (ECMO) for refractory ARDS. He was initiated on venovenous ECMO via dual-site cannulation performed at the bedside. Although his ECMO course was complicated by bleeding, he showed a remarkable improvement
in his lung function. ECMO was successfully decannulated after 17 days of initiation. The patient was discharged home after 47 days of hospitalization without any supplemental oxygen and was able to undergo active physical rehabilitation. |
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Rambaldi, A, Gritti, et al |
Immunobiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
In this study, the first time a lectin-pathway inhibitor was used to treat COVID-19, six COVID-19 patients with ARDS
requiring continuous positive airway pressure (CPAP) or intubation received narsoplimab under compassionate use. At baseline and during treatment, circulating endothelial cell (CEC) counts and serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8), C-reactive
protein (CRP) and lactate dehydrogenase (LDH) were assessed. Narsoplimab treatment was associated with rapid and sustained reduction of CEC and concurrent reduction of serum IL-6, IL-8, CRP and LDH. Narsoplimab was well tolerated; no adverse drug reactions
were reported. Two control groups were used for retrospective comparison, both showing significantly higher mortality than the narsoplimab-treated group. All narsoplimab-treated patients recovered and survived. |
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Ranjan, P, Kumar, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study explored the association between BMI and COVID-19 positive status in a tertiary care hospital from New Delhi.
Three hundred and seventy nine adult patients who presented to COVID-19 screening outpatient department of the hospital were interviewed over the phone regarding their body weight and height. The COVID-19 RT-PCR report of the patients was extracted from the
hospital information system. The mean BMI and the prevalence of obesity was observed to be higher in individuals who were detected to be COVID-19 RT-PCR positive as compared to those who were negative. With every one-unit increment in BMI above 23 kg/m2, the
odds of being COVID-19 positive increased by 1.8 times among these patients. |
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Rasheed, AM, Fatak, et al |
Le infezioni in medicina |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
Forty nine early-stage critically-ill COVID-19 patients residing in Respiratory Care Units (RCU) of three hospitals
in Baghdad, Iraq, were included: 21 received convalescent plasma while 28, namely control group, did not receive it. Patients who received convalescent plasma showed reduced duration of infection in about 4 days and showed less death rate [1/21 versus 8/28
in control group]. In addition, all the patients who were given convalescent plasma showed high levels of SARS-CoV-2 IgG and IgM three days after plasma transfusion. Plasma from donors with high levels of SARS-CoV-2 IgG and donors with positive SRAS-CoV-2
IgM showed better therapeutic results than other donors. |
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Reggio Emilia Covid-19 Working, Group |
Epidemiologia e prevenzione |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
We report that immigrants resident in Reggio Emilia province, mostly coming from Countries with high BCG vaccination
coverage, and Italians had a similar prevalence of infection (odds ratio - OR 0.99; 95%CI 0.82-1.20) and similar probability of being tested (OR 0.93; 95%CI 0.81-1.10). |
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Ren, Wenlin, Hu, et al |
bioRxiv |
Coronavirology| Coronavirologie Animal model | Modèle animal |
To better understand the genetic determinants behind the ability of ACE2 orthologs to support viral entry, we compared
koala and mouse ACE2 sequences with that of human and identified the key residues in koala and mouse ACE2 that restrict viral receptor activity. Humanization of these critical residues rendered both koala and mouse ACE2 capable of binding the spike protein
and facilitating viral entry. The single mutation that allowed for mouse ACE2 to serve as a viral receptor provides a potential avenue for the development of SARS-CoV-2 mouse model. |
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Ren, Y, Yin, et al |
Natural Product Communications |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study aimed at exploring the active components and mechanisms of Jinhua Qinggan granules (JQG) in the prevention
and treatment of coronavirus disease 2019 (COVID-19) using network pharmacology and molecular docking technology. Visualization analysis demonstrated that the core active components of JQG had a strong affinity for SARS-CoV-2 3CL hydrolase, SARS-CoV-2 S protein,
ACE2, and SOCS1. These data imply that the potential active components of JQG may act on multiple signaling pathways by binding to targets such as SARS-CoV-2 3CL hydrolase, S protein, ACE2, and SOCS1, thereby inhibiting virus replication and targeting cell
binding, reducing host inflammation, and activating antiviral immunity to a certain extent. |
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SEIR epidemic model for COVID-19 transmission by Caputo derivative of fractional
order |
Rezapour, S, Mohammadi, et al |
Advances in Difference Equations |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We provide a SEIR epidemic model for the spread of COVID-19 using the Caputo fractional derivative. The feasibility
region of the system and equilibrium points are calculated and the stability of the equilibrium points is investigated. We prove the existence of a unique solution for the model by using fixed point theory. Using the fractional Euler method, we get an approximate
solution to the model. To predict the transmission of COVID-19 in Iran and in the world, we provide a numerical simulation based on real data. © 2020, The Author(s). |
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Rhee, C, Baker, et al |
JAMA network open |
Epidemiology| Épidémiologie |
Objective: To assess the incidence of COVID-19 among patients hospitalized at a large US academic medical center.
Over the 12-week period, 9149 patients (mean [SD] age, 46.1 [26.4] years; median [IQR] age, 51 years [30-67 years]; 5243 female [57.3%]) were admitted to the hospital, for whom 7394 SARS-CoV-2 RT-PCR tests were performed; 697 COVID-19 cases were confirmed,
translating into 8656 days of COVID-19-related care. Twelve of the 697 hospitalized patients with COVID-19 (1.7%) first tested positive on hospital day 3 or later (median, 4 days; range, 3-15 days). Of these, only 1 case was deemed to be hospital acquired,
most likely from a presymptomatic spouse who was visiting daily and diagnosed with COVID-19 before visitor restrictions and masking were implemented. Among 8370 patients with non-COVID-19-related hospitalizations discharged through June 17, 11 (0.1%) tested
positive within 14 days (median time to diagnosis, 6 days; range, 1-14 days). Only 1 case was deemed likely to be hospital acquired, albeit with no known exposures. |
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Riccò, M, Vezzosi, et al |
Acta bio-medica : Atenei Parmensis |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
Overall, the sampled population included 2106 respondents, and 39.3% were HCWs. Even though HCWs were more likely to
exhibit a better understanding of SARS-CoV-2/COVID-19 related issues (aOR 2.195, 95%CI 1.809 to 2.664), they were not exempt for misunderstandings, particularly on actual incidence and lethality of COVID-19. |
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Coupling between COVID-19 and seasonal influenza leads to synchronization of their dynamics |
Rodriguez, JorgeP, Eguiluz, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Interactions between COVID-19 and other pathogens may change their dynamics. Specifically, this may hinder the modelling
of empirical data when the symptoms of both infections are hard to distinguish. We introduce a model coupling the dynamics of COVID-19 and seasonal influenza, simulating cooperation, competition and asymmetric interactions. We find that the coupling synchronizes
both infections, with a strong influence on the dynamics of influenza, reducing its time extent to a half. |
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32908584; Utility-Based Multicriteria Model for Screening Patients under the COVID-19
Pandemic |
Roselli, LRP, Frej, et al |
Computational and mathematical methods in medicine |
Healthcare Response | Réponse des soins de santé |
In this paper, a utility-based multicriteria model is proposed to support the physicians to deal with an important
medical decision-the screening decision problem-given the squeeze put on resources due to the COVID-19 pandemic. Since the COVID-19 emerged, the number of patients with an acute respiratory failure has increased in the health units. This chaotic situation
has led to a deficiency in health resources. Thus, this study, using the concepts of the multiattribute utility theory (MAUT), puts forward a mathematical model to aid physicians in the screening decision problem. The model is used to generate which of the
three alternatives is the best one for where patients with suspected COVID-19 should be treated, namely, an intensive care unit (ICU), a hospital ward, or at home in isolation. Also, a decision information system, called SIDTriagem, is constructed and illustrated
to operate the mathematical model proposed. Copyright © 2020 Lucia Reis Peixoto Roselli et al. |
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Ruiz de Angulo, D, Balaguer Román, et al |
Cirugia Espanola |
Public Health response| Interventions de santé publique |
Our aim was to determine the influence that this condition had over the short-term ponderal results of patients undergoing
laparoscopic vertical gastrectomy from May 2019 to May 2020. Case-control study for comparing the percentage of excess weight lost (%EWL) and the percentage of total weight lost (%TWL) of patients that underwent a VG during the last year, so they were affected
by lockdown in April and part of March 2020 (group 1), to the %EWL and %TWL of a control group (group 2), obtained from our previous series. The mean %EWL in group 1 is 47,37 ± 18,59 and in group 2 is 51,13 ± 17,59, being p = 0,438. Meanwhile, the mean %TWL
in group 1 is 21,14 ± 8,17 and in group 2 is 24,67 ± 8,01, with p = 0,115. |
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Social entrepreneurial intention and the impact of COVID-19 pandemic: A structural model |
Ruiz-Rosa, I, Gutiérrez-Taño, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
Based on the Theory of Planned Behavior (TPB), an explanatory structural model of social entrepreneurial intention
was tested, and the impact of the COVID-19 crisis on this intention was evaluated. To do this, a quantitative investigation was conducted using a survey of Spanish university students, obtaining a total of 558 responses: 324 before the COVID-19 crisis and
234 during the crisis period (February and June 2020). The results obtained make it possible to validate the explanatory model of social entrepreneurial intention from the perspective of the TPB. In addition, it shows that social entrepreneurial intention
decreases in times of deep socioeconomic crises and high uncertainty, such as that caused by COVID-19. |
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Rukuni, TF, Maziriri, et al |
Data Brief |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
This data article describes raw statistics on occupational health and safety strategies influencing the reduction of
coronavirus in South Africa. The purpose of this research was to investigate factors that could potentially influence the reduction of the spread of COVID-19 in a municipality setting. The following independent constructs are explored: physical wellness, psychological
wellness, Intellectual wellness, intellectual wellness, emotional wellness and social wellness. In addition to the individual dependent variables, the influence of these constructs on the reduction of COVID-19 transmission and employee performance at a selected
municipality was tested. Hypotheses emerged from the proposed influence of each of these constructs on reduction of COVID-19 transmission at a municipality. Smart PLS was used to measure the impact of the proposed hypotheses of the research. In order to describe
data on the respondents' characteristics, SPSS and SMART PLS was used to generate the relevant statistics. The data generated for this research could potentially advise on how healthy and safety strategies could contribute to lowering the transmission of COVID-19
at a municipality. |
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32827748; Sheltered Neurosurgery During COVID-19: The Emory Experience |
Saad, H, Alawieh, et al |
World Neurosurgery |
Healthcare Response | Réponse des soins de santé |
We describe the neurosurgical experience at Emory University during the COVID-19 pandemic and the impact of COVID-19-related
policies on resident experience. We retrospectively reviewed all neurosurgical cases performed at Emory University Hospital between March 16, the day cancellation of elective cases was effective, and April 15, 2020, and the same period in the preceding 3
years. For the study period, we collected the number of cases and their distribution by subspecialty along with total hospital charges. Compared with an average of 606 cases performed during the study period over the past 3 years, only 145 neurosurgical cases
were performed between March 16 and April 15, 2020, which corresponds to an 80% reduction in case volume and 66% decrease in hospital revenue in 2020. Even at academic centers that were not hugely impacted by the COVID-19 pandemic, prophylactic and preparedness
measures still exhibited an unprecedented toll on neurosurgical resident and fellow experience. |
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Immune life history, vaccination, and the dynamics of SARS-CoV-2 over the next 5 years |
Saad-Roy, C, Wagner, et al |
Science |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
The future trajectory of the Covid-19 pandemic hinges on the dynamics of adaptive immunity against SARS-CoV2; however,
salient features of the immune response elicited by natural infection or vaccination are still uncertain. We use simple epidemiological models to explore estimates for the magnitude and timing of future Covid-19 cases given different protective efficacy and
duration of the adaptive immune response to SARS-CoV-2, as well as its interaction with vaccines and nonpharmaceutical interventions. We find that variations in the immune response to primary SARS-CoV-2 infections and a potential vaccine can lead to dramatically
different immune landscapes and burdens of critically severe cases, ranging from sustained epidemics to near elimination. Our findings illustrate likely complexities in future Covid-19 dynamics, and highlight the importance of immunological characterization
beyond the measurement of active infections for adequately projecting the immune landscape generated by SARS-CoV-2 infections. |
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Student emotion estimation based on facial application in E-learning during
COVID-19 pandemic |
Sabri, N, Musa, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Public Health response| Interventions de santé publique |
This study focuses on the estimation of student emotion based on facial application in e-learning during the COVID-19
pandemic. This research aims to improve current e-learning method by identify emotion recognition of student on e-learning during pandemic while linking emotion detection to adapted learning activities. The classification accuracy using SVR shows promising
result on identify four (4) types of face emotion which is happy, normal, surprise and sad. Further development of other human recognition, such as speech, will be done in the future to enhance online e-learning, especially during the COVID-19 pandemic. |
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Two seriously ill neonates born to mothers with COVID-19 pneumonia- a case report |
Sagheb, S, Lamsehchi, et al |
Ital J Pediatr |
Transmission Clinical data| Données cliniques |
In this report, we present two seriously ill neonates who were born from mothers with stablished COVID-19 pneumonia.
Laboratory tests showed lymphopenia with high LDH and hypocalcemia right after the birth. They had fever for days without responding to antibiotics and despite ruling out other potential causes. Both patients had positive RTPCR for SARS-COV-2 in the second
round of testing but the first assay tested was negative. Hydroxychloroquine was used to treat both patients; the first patient was treated with it over a period of 14 days before showing signs of improvement. The second patient responded to the treatment
over a period of 5 days. Although based on the available evidences, vertical transmission of COVID-19 is less likely, many aspects of pathogenesis and transmission of this novel virus are still unclear. |
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COVID-19 image classification using deep features and fractional-order marine predators
algorithm |
Sahlol, AT, Yousri, et al |
Sci Rep |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper, we propose an improved hybrid classification approach for COVID-19 images by combining the strengths
of CNNs (using a powerful architecture called Inception) to extract features and a swarm-based feature selection algorithm (Marine Predators Algorithm) to select the most relevant features. A combination of fractional-order and marine predators algorithm (FO-MPA)
is considered an integration among a robust tool in mathematics named fractional-order calculus (FO). The proposed approach was evaluated on two public COVID-19 X-ray datasets which achieves both high performance and reduction of computational complexity.
The proposed approach selected successfully 130 and 86 out of 51 K features extracted by inception from dataset 1 and dataset 2, while improving classification accuracy at the same time. The results are the best achieved on these datasets when compared to
a set of recent feature selection algorithms. By achieving 98.7%, 98.2% and 99.6%, 99% of classification accuracy and F-Score for dataset 1 and dataset 2, respectively, the proposed approach outperforms several CNNs and all recent works on COVID-19 images. |
|
Sakai, T, Hoshino, et al |
Journal of Rehabilitation Medicine |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study aimed to describe the effectiveness and risk management of remote rehabilitation for coronavirus disease
(COVID-19) patients. Out of a total of 43 patients, 14 were initially provided with remote rehabilitation and 29 with direct rehabilitation. Four patients were switched from direct to remote rehabilitation during the study, thus at the end of the study there
were 18 in the remote rehabilitation group and 25 in the direct rehabilitation group. Patients in remote rehabilitation were significantly younger than those in direct rehabilitation. Of 12 patients who required intubation, 3 were given remote rehabilitation.
One extracorporeal membrane oxygenation survivor underwent direct rehabilitation. All patients on remote rehabilitation were discharged home or to a hotel. Twelve out of 29 patients were transferred to a rehabilitation hospital due to delayed recovery of activities
of daily living. No serious adverse events occurred. |
|
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Knowledge, attitude and practices related to COVID-19 among young Lebanese
population |
Sakr, Samer, Ghaddar, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
This study aims to test the knowledge, attitude and practices (KAP) towards COVID-19 in Lebanon. A cross-sectional
study of Lebanese population comprising of 1861 participants was used to analyze the knowledge, attitude and practices of individuals concerning COVID-19 in relationship to multiple variables such as age, gender, marital status, living area, education level,
occupation in addition to their degree of worrying about this disease. Our participants showed an overall appropriate knowledge (67.1%), positive attitude and practices that ranged from fair to very good, depending on its type, regarding COVID-19. In the absence
of a vaccine, pandemics such as the current COVID-19 are best combatted by increasing public awareness leading to collective preventative practices. A key factor in this effort lies in creating a good environment that enhances people’s compliance with considerate
pandemic behavioral rules in which governing bodies must be pivotal. |
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Incidence of anxiety in epilepsy during coronavirus disease (COVID-19) pandemic |
Salari, M, Etemadifar, et al |
Epilepsy and Behavior |
Public Health response| Interventions de santé publique |
Purpose: The coronavirus disease 2019 (COVID-19) pandemic has affected people globally, and people with chronic diseases
are suffering more in maintaining their mental and physical health. Method: This cross-sectional, case–control study assessed the anxiety level in people with epilepsy compared with the general population. Results: The results showed that 13.5% of patients
had experienced a severe level of anxiety, but the mean anxiety level between groups did not show significant difference. Conclusion: Although still many aspects of the pandemic on people with epilepsy are yet to be determined, active investigation of psychological
sequels of the pandemic is demanded. © 2020 Elsevier Inc. |
|
Sankar, P, Venugopal, et al |
International Journal of Pharmaceutical Research |
Coronavirology| Coronavirologie Immunology | Immunologie |
Immuno- informatics based approach for identifying the highly immunogenic B and T-cell epitopes of the surface glycoprotein
of the SARS-CoV-2 was performed in IEDB server. The chosen epitopes were analysed for the binding potential with the MHC alleles using Patch dock server. The results revealed greater binding interactions between the selected peptides and MHC-Dd allele (co-crystallised
with TAPBPR). Recognized epitopes may serve as target candidates for development of vaccines to combat the dreadful communicable infectious disease. |
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Santamaria, C, Sermi, et al |
Saf Sci |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This work presents a mobility indicator derived from fully anonymised and aggregated mobile positioning data. Even
though the indicator does not provide information about the behaviour of individuals, it captures valuable insights into the mobility patterns of the population in the EU and it is expected to inform responses against the COVID-19 pandemic. Spatio-temporal
harmonisation is carried out so that the indicator can provide mobility estimates comparable across European countries. The indicators are provided at a high spatial granularity (up to NUTS3). As an application, the indicator is used to study the impact of
COVID-19 confinement measure on mobility in Europe. It is found that a large proportion of the change in mobility patterns can be explained by these measures. The paper also presents a comparative analysis between mobility and the infection reproduction number
Rt over time. These findings will support policymakers in formulating the best data-driven approaches for coming out of confinement, mapping the socio-economic effects of the lockdown measures and building future scenarios in case of new outbreaks. |
|
|
32902237; Evaluation of Routine Blood Tests for Diagnosis of Suspected Coronavirus
Disease 2019 |
Santotoribio, JD, Nuñez-Jurado, et al |
Clinical laboratory |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The aim was to evaluate the routine blood tests for diagnosis of COVID-19, determining the diagnostic accuracy of blood
biomarkers to differentiate between patients with and without COVID-19. Clinical charts, nursing records, laboratory findings, and chest x-rays from adult patients with clinical suspicion of COVID-19 (fever, cough and/or dyspnea) at hospital admission were
reviewed. Two hundred three patients (101 females, 102 males) with ages between 18 and 96 years (mean = 61.3) were studied. Blood counts of lymphocytes and eosinophils, and plasma levels of D-dimer, LDH, hsCRP, and ferritin can be used to differentiate patients
with and without COVID-19 and as a tool for diagnosis of suspected COVID-19 in adult patients at hospital admission. |
|
Sarfraz, A, Sarfraz, et al |
J Occup Environ Med |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
OBJECTIVE: To assess the discrepancy among and within low- and middle-income countries (LMICs) regarding PPE availability,
use, and satisfaction. METHODS: The study population consisted of healthcare workers from LMICs who partook in the questionnaire survey from March 1, 2020, until April 15, 2020. RESULTS: In the bivariate analysis, gender (p = 0.05), HCWs (p < 0.01), and of
care (p < 0.01) were associated with the public or private sector (p < 0.05). Using multivariate analysis, PPE factors were associated with the health sector (p < 0.05). The multivariate logistic regression model determined a Pearson's χ2 of 706.736 (d.f. = 726,
p = -0.689) and a c-statistic of 0.592, indicating a good model. CONCLUSION: In LMICs, huge discrepancies are present in PPE provision to HCWs, especially among the public healthcare sectors. Efforts at national and international protective levels ought to
be addressed to protect frontline HCWs at higher risk of contracting COVID-19. |
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Sarkar, A, Chouhan, et al |
Clinical Epidemiology and Global Health |
Epidemiology| Épidémiologie |
The objective of the present work is to construct a socio-environmental vulnerability index of the potential risk of
community spread of COVID-19 using socio-economic and environmental variables. In this, cross-sectional study principal component analyses have been used to drive SoEVI. 4 uncorrelated sub-index has been extracted from 16 sub-indicators which reflects 59%
of the variance. Results show that there is spatial variability in vulnerability based on environmental and socio-economic conditions. The vulnerability index has highlighted environmentally and socioeconomically backward districts. |
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Methylprednisolone pulse therapy: An alternative management of severe COVID-19 |
Sauñe, PM, Bryce-Alberti, et al |
Respiratory Medicine Case Reports |
Clinical data| Données cliniques Immunology | Immunologie |
We present two cases of severe COVID-19 that were rejected by medical institutions. The management of the disease was
done at home with methylprednisolone (MP) pulse therapy for three days. This resulted in a favorable evolution and resolution of most symptoms. COVID-19 infection presents as asymptomatic disease, non-severe symptomatic disease, and severe respiratory inflammatory
disease. The first two forms are dependent on viral response and a “cytokine storm” is responsible for the progression into severe disease. Glucocorticoids (GC) reduce inflammation by different mechanism depending of their concentration. Pulses lead to overall
apoptosis of immune cells. Studies using pulse MP as treatment for SARS-CoV-1 showed clinical improvement and decreased incidence of ARDS compared with patients who received low dose steroid treatment. Inhibition of excessive inflammation through timely administration
of GC in the early stage of inflammatory cytokine storm effectively prevents the occurrence of ARDS. © 2020 |
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Schlicht, K, Rohmann, et al |
Int J Obes (Lond) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Since metabolic diseases are major risk factors for the present COVID-19 pandemic, we examined circulating soluble
DPP-4 serum concentrations in patients suffering from severe COVID-19 infection and in healthy human subjects in a case control design. In this analysis sDPP-4 levels were significantly lower in COVID-19 patients compared to controls (242.70 ± 202.12 ng/mL
versus 497.70 ± 188.13 ng/mL, p = 0.02). We also examined sDPP-4 serum concentrations in patients suffering from sepsis not due to corona-like viruses. In these subjects, sDPP-4 levels were not different compared to healthy case controls (p = 0.14), which
might suggest the decrease of sDPP-4 to be specific for corona-like virus infections. Currently, most data point towards membrane bound ACE2 in contrast to DPP-4 as the major binding partner for COVID-19 internalization into host immune cells. However, the
finding that the circulating soluble form of DPP-4 is reduced in hospitalized patients might suggest a regulatory role for both, ACE and DPP-4, in COVID-19 infections, especially since obesity and type 2 diabetes are major risk factor for a severe course of
the disease |
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Schramm, MA, Venhoff, et al |
Frontiers in Immunology |
Clinical data| Données cliniques |
Immunosuppressive therapies increase the susceptibility of patients to infections. The current pandemic with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compels clinicians to develop recommendations for successful clinical management and surveillance of immunocompromised patients at high risk for severe disease progression. With only few case studies published
on SARS-CoV-2 infection in patients with rheumatic diseases, we report a 25-year-old male who developed moderate coronavirus disease 2019 (COVID-19) with fever, mild dyspnea, and no major complications despite having received high-dose prednisolone, cyclophosphamide,
and rituximab for the treatment of highly active, life-threatening eosinophilic granulomatosis with polyangiitis (EGPA). |
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Schuengel, C, Tummers, et al |
J Intellect Disabil Res |
Public Health response| Interventions de santé publique |
This study tested changes in reported incidents, in particular regarding aggression, unexplained absence and, for contrast,
medication errors. Metadata on weekly incident and near-incident reports from 2016 to June 2020 involving over 14 000 clients with mild to serious intellectual disability of 's Heeren Loo, a long-term care organisation for people with intellectual disability,
were subjected to interrupted time series analysis, comparing the COVID-19 with the pre-COVID-19 period. The imposition of lockdown-measures coincided with a significant drop in incidents (total, P < .001; aggression, P = .008; unexplained absences, P = .008;
and medication errors, P < .001). The rise in incidents involving aggression, against the background of generally lowered reporting, underlines the need for pandemic control measures that are suitable for people with intellectual disability in long-term care. |
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Pulmonary embolism in COVID-19 pneumonia: An overlapping diagnosis or a misdiagnosis? |
Secco, E, Pasqualetto, et al |
Journal of Cardiovascular Echography |
Clinical data| Données cliniques |
Coronavirus pneumonia (COVID-19) is a novel infectious disease with a high mortality rate due to severe acute respiratory
syndrome. A 57-year-old woman was admitted to the emergency department (ED) with fever, cough, atypical chest pain, and dyspnea. She remained in the ED for about 48 h while waiting for the result of the COVID-19 oropharyngeal swab. Once she tested positive,
she was hospitalized in the pneumological department with a diagnosis of pneumonia based on a chest X-ray and biochemical tests. Although azithromycin and hydroxychloroquine were promptly administered, she had a worsening of dyspnea even with a high-flow oxygen
mask. D-dimer was increased, and a computed tomography scan with pulmonary and leg angiogram was positive for bilateral pulmonary embolism, deep-venous thrombosis, and multiple consolidated opacities in the lung parenchyma. This case highlights the fact that,
in a pandemic situation, there is a potentially fatal risk of overlooking an alternative diagnosis in a COVID-19 patient who is generally considered as suffering only from pneumonia. © 2020 Wolters Kluwer Medknow Publications. All rights reserved. |
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Segarra, B, Ballesteros Heras, et al |
J Orthop Trauma |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
OBJECTIVES: To describe clinical characteristics of fracture patients, including a closer look to hip fracture patients,
and determine how epidemiological variables may have influenced on a higher vulnerability to SARS-CoV-2 infection, as the basis for the considerations needed to reintroduce elective surgery during the pandemic. DESIGN: Longitudinal prospective cohort study.
SETTING: Level I Trauma Center in the East of Spain. PATIENTS/PARTICIPANTS: One hundred forty-four consecutive fracture patients 18 years or older admitted for surgery. INTERVENTION: Patients were tested for SARS-CoV-2 with either molecular and/or serological
techniques and screened for presentation of COVID-19. MAIN OUTCOME MEASUREMENTS: Patients were interviewed and charts reviewed for demographic, epidemiological, clinical, and surgical characteristics. RESULTS: We interviewed all patients and tested 137 (95.7%)
of them. Three positive patients for SARS-CoV-2 were identified (2.1%). One was asymptomatic and the other 2 required admission due to COVID-19-related symptoms. Mortality for the whole cohort was 13 patients (9%). Significant association was found between
infection by SARS-CoV-2 and epidemiological variables including: intimate exposure to respiratory symptomatic patients (P = 0.025) and intimate exposure to SARS-CoV-2-positive patients (P = 0.013). No association was found when crowding above 50 people was
tested individually (P = 0.187). When comparing the 2020 and 2019 hip fracture cohorts we found them to be similar, including 30-day mortality. A significant increase in surgical delay from 1.5 to 1.8 days was observed on the 2020 patients (P = 0.034). CONCLUSIONS:
Patients may be treated safely at hospitals if strict recommendations are followed. Both cohorts of hip fracture patients had similar 30-day mortality. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels
of evidence. |
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Senthil Kumar, KJ, Vani, et al |
Plants |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study, we evaluated the ACE2 inhibitory effects of 10 essential oils. Among them, geranium and lemon oils displayed
significant ACE2 inhibitory effects in epithelial cells. In addition, immunoblotting and qPCR analysis also confirmed that geranium and lemon oils possess potent ACE2 inhibitory effects. Furthermore, the gas chromatography-mass spectrometry (GC–MS) analysis
displayed 22 compounds in geranium oil and 9 compounds in lemon oil. Citronellol, geraniol, and neryl acetate were the major compounds of geranium oil and limonene that represented major compound of lemon oil. Next, we found that treatment with citronellol
and limonene significantly downregulated ACE2 expression in epithelial cells. The results suggest that geranium and lemon essential oils and their derivative compounds are valuable natural anti-viral agents that may contribute to the prevention of the invasion
of SARS-CoV-2/COVID-19 into the human body. |
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Sethi, M, Pandey, et al |
|
Public Health response| Interventions de santé publique |
The goal of this study is to present a domain-specific approach to understand sentiments manifested within people around
the globe regarding this situation. In order to attain this, corona-specific tweets are acquired from twitter platform. After gathering the tweets, they are labelled and a model is developed which is effective for detecting the actual sentiment behind a tweet
related to COVID-19. The substantial assessments are performed in bi-class and multi-class setting over n-gram feature set along with cross-dataset evaluation of different machine learning techniques in order to develop the model. Our experiments reveal that
the proposed model performs well in perceiving the perception of people about COVID-19 with a maximum accuracy of about 93%. |
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Shah, A, Rashid, et al |
Gene Rep |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
As RNA viruses have a high mutation rate therefore we wanted to identify whether this virus is also prone to mutations.
For this reason we selected four major structural (Spike protein (S), Envelope protein (E), Membrane glycoprotein (M), Nucleocapsid phosphoprotein (N)) and ORF8 protein of 100 different SARS-CoV-2 isolates of fifteen countries from NCBI database and compared
these to the reference sequence, Wuhan NC_045512.2, which was the first isolate of SARS-CoV-2 that was sequenced. By multiple sequence alignment of amino acids, we observed substitutions and deletion in S protein at 13 different sites in the isolates of five
countries (China, USA, Finland, India and Australia) as compared to the reference sequence. Thus, we observed several mutations in the isolates thereafter the first sequencing of SARS-CoV-2 isolate, NC_045512.2, which suggested that this virus might be a threat
to the whole world and therefore further studies are needed to characterize how these mutations in different proteins affect the functionality and pathogenesis of SARS-CoV-2. |
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Shaharudin, SM, Ismail, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Recently, a forecasting model was developed to measure and predict daily Covid-19 cases in Malaysia for the coming
10 days using previously-confirmed cases. A Singular Spectrum Analysis-based forecasting model that discriminates noise in a time series trend is introduced. These results show that the parameter L= 4 (T/20) for RF-SSA model was suitable for short time series
outbreak data and the appropriate number of eigentriples to obtain is important as it influences the forecasting result. Evidently, the RF-SSA has over-forecasted the cases by 0.36%. This indicates RF-SSA’s competence to predict the impending number of Covid-19
cases. Nevertheless, enhanced RF-SSA algorithm should to be developed for higher effectivity in capturing any extreme data changes. |
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Shang, W, Li, et al |
Int Urol Nephrol |
Clinical data| Données cliniques |
PURPOSE: This present study aims to investigate the relationship between laboratory parameters on admission and prognosis
of coronavirus disease 2019 (COVID-19) in maintenance hemodialysis patients, as well as providing a theoretical basis for clinical evaluation of prognosis and corresponding intervention measures. METHODS: Retrospective analysis was performed on the clinical
data of 47 maintenance hemodialysis patients who infected with COVID-19 and admitted to our hospital. According to their clinical outcome, these patients were divided into a survival group (n = 38) and a fatality group (n = 9). Information on the general condition
and laboratory parameters of the patients were collected. Laboratory parameters were compared between different groups. The area under the curve (AUC) was used to evaluate the prognosis of COVID-19 in maintenance hemodialysis patients. RESULTS: Statistically
significant differences were observed in age, white blood cell count, neutrophil count, albumin, C-reactive protein (CRP), procalcitonin, and lactate dehydrogenase (LDH) on admission (P < 0.05). Receiver operating characteristic (ROC) curve analysis showed
that the values of AUC of CRP, neutrophil count, LDH, white blood cell count, albumin, and procalcitonin were 0.895, 0.813, 0.758, 0.757, 0.743, and 0.728, respectively. CONCLUSIONS: Laboratory parameters including CRP, neutrophil count, LDH, white blood cell
count, albumin, and procalcitonin were predictive on the prognosis of maintenance hemodialysis patients with COVID-19. Among them, CRP was the strongest single predictive laboratory indicator. |
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Shanmugarajan, D, P, et al |
RSC Advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Fourteen natural curcuminoids were studied for their possibility of inhibiting SARS-CoV-2. We studied their in silico
properties towards SARS-CoV-2 target proteins by homology modelling, ADME, drug-likeness, toxicity predictions, docking molecular dynamics simulations and MM-PBSA free energy estimation. Among the curcuminoids docked to the receptor binding domain of SARS-CoV-2
spike glycoprotein, the keto and enol forms of curcumin form strong hydrogen bond interactions with ACE2 binding residues Q493, T501, Y505, Y489 and Q498. Molecular dynamics simulations, free energy binding and interaction energy validated the interaction
and stability of the docked keto and enol forms of curcumin. |
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Shayak, B, Sharma, et al |
|
Modelling/ prediction| Modélisation/prédiction Transmission |
In this work we give a delay differential equation, the retarded logistic equation, as a mathematical model for the
global transmission of COVID-19. This model accounts for asymptomatic carriers, pre-symptomatic or latent transmission as well as contact tracing and quarantine of suspected cases. We find that the equation admits varied classes of solutions including self-burnout,
progression to herd immunity and multiple states in between. We use the term “partial herd immunity” to refer to these states, where the disease ends at an infection fraction which is not negligible but is significantly lower than the conventional herd immunity
threshold. We believe that the spread of COVID-19 in every localized area can be explained by one of our solution classes. © 2020, Copyright held by the author(s). |
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Shen, M, Tong, et al |
Zhejiang Da Xue Xue Bao Yi Xue Ban |
Healthcare Response | Réponse des soins de santé |
This study aimed to evaluate the application of three-in-one intelligent screening in outpatient pre-inspection in
Children's Hospital. We randomly enrolled 100 children pre-screened by traditional in the outpatient department of Children's Hospital Zhejiang University School of Medicine from February 6th to 16th, 2020, and another 100 children by the intelligent three-in-one
mode from February 17th to 27th, 2020. For on-line registered patients, the system automatically sent the COVID-19 epidemiological pre-screening triage questionnaire one hour before the appointment, requiring parents to complete and submit online before arriving
at the hospital. The three-in-one intelligent pre-inspection mode took an average of (25.6±8.0) seconds for each child, which was significantly shorter than the traditional pre-inspection mode (74.8±36.4 seconds) (t=13.182, P0.05). The three-in-one intelligent
pre-inspection model can effectively shorten the patient pre-check time, with similar triage coincidence rate to traditional model. |
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On the detection of covid-19 from chest x-ray images using cnn-based transfer learning |
Shorfuzzaman, M, Masud, et al |
Computers, Materials and Continua |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this research, we show how convolutional neural network (CNN) can be useful to detect COVID-19 using chest X-ray
images. We leverage the CNN-based pre-trained models as feature extractors to substantiate transfer learning and add our own classifier in detecting COVID-19. In this regard, we evaluate performance of five different pre-trained models with fine-tuning the
weights from some of the top layers. We also develop an ensemble model where the predictions from all chosen pre-trained models are combined to generate a single output. The models are evaluated through 5-fold cross validation using two publicly available
data repositories containing healthy and infected (both COVID-19 and other pneumonia) chest X-ray images. We also leverage two different visualization techniques to observe how efficiently the models extract important features related to the detection of COVID-19
patients. The models show high degree of accuracy, precision, and sensitivity. We believe that the models will aid medical professionals with improved and faster patient screening and pave a way to further COVID-19 research. |
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Shukla, V, Lau, et al |
J Occup Environ Med |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé Immunology
| Immunologie |
OBJECTIVE: There is currently over 80,000 cases of COVID-19 in Arizona, and the number is rapidly increasing, leading
the country in the rate of new daily cases. Exposure among first responders remains unknown. METHODS: Rates of SARS-CoV-2 IgG among first responders in Arizona were determined, and attitudes / views about the impact of COVID-19 on their work life was analyzed.
RESULTS: Of 3,326 first responders, 50 (1.50%) tested positive for SARS-CoV-2 IgG. Most first responders thought antibody testing would help ease their anxieties (62.5%) and be beneficial to their work-life (60.6%). CONCLUSION: The rate of COVID-19 exposure
among first responders in Arizona is low - 1.50%. COVID-19 is a concern among many of the first responders, and antibody testing was beneficial in easing their anxieties about going to work and performing work-related duties. |
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Si, Y, Zhao, et al |
BMC Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A total of 2188 patients with clinically suspected of COVID-19 in Southwest China were recruited from January 21 to
February 29, 2020. Nasopharyngeal swabs, throat swabs and sputum specimens were collected to detect SARS-CoV-2 by using real-time reverse transcription-polymerase chain reaction (RT-PCR) and other 12 viruses via PCR fragment analysis combined with capillary
electrophoresis. Only 1.1% (24/2188) patients with suspected COVID-19 were eventually confirmed to have SARS-CoV-2 infection, and the most frequently observed symptoms were fever (75.0%, 18/24) and cough (20.8%, 5/24). This study reveals the epidemiological
features of common respiratory viruses and their clinical impact during the ongoing outbreak of COVID-19 in a mild epidemic area. |
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Correlation between premorbid IL-6 levels and COVID-19 mortality: Potential role
for Vitamin D |
Silberstein, M |
International immunopharmacology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To identify whether IL-6 levels prior to infection might predict outcome, early data on COVID-19 mortality from Italy
and the UK were compared with previously published results of mean IL-6 levels from these countries as well as from the USA. There was a highly significant correlation (r = 0.9883; p = 0.00025) between age-stratified mortality rates and IL-6 levels from previously
published data on healthy individuals. To determine whether Vitamin D may be beneficial at lowering IL-6 levels in patients, a limited analysis of trials examining the relationship between these entities published since 2015 was undertaken. Eight out of 11
studies described a significant lowering effect of Vitamin D on IL-6. Given that IL-6 likely facilitates viral cell entry and replication, levels prior to infection may predict mortality. This provides a rationale for prophylactic and therapeutic measures
directed at lowering IL-6, including Vitamin D prescription. |
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Singh, P, Cumberland, et al |
Journal of medical Internet research |
Public Health response| Interventions de santé publique |
BACKGROUND: Evidence from past pandemics suggests that fear, uncertainty, and loss of control during large-scale public
health crises may lead to increased pandemic-related information seeking, particularly among persons predisposed to high anxiety. In such groups, a greater consumption of information pertaining to the COVID-19 pandemic may increase anxiety. OBJECTIVE: In this
study, we examine the association between online activity and Generalized Anxiety Disorder 7 (GAD-7) scores in the United States. METHODS: We recruited participants for an online survey through advertisements on various platforms such as Google, Facebook,
and Reddit. A total of 406 adult US participants with moderate to severe (≥10) GAD-7 scores met the inclusion criteria and completed the survey. Anxiety levels measured using the GAD-7 scale formed our primary outcome. Our key independent variables were average
daily time spent online and average daily time spent online searching about COVID-19 within the past 14 days. We used as controls potential confounders of the relation between our key independent variables and GAD-7 scores, namely, sleep quality, the COVID-19
Fear Inventory scale, binge drinking, substance use, prescription drug abuse, and sociodemographic attributes. RESULTS: Linear multivariate regression analyses showed that GAD-7 scores were higher among those who spent >4 hours online (per day) searching for
information about COVID-19 (coefficient 1.29, P=.002), controlling for all other covariates. The total time spent online was not statistically associated with GAD-7 scores. CONCLUSIONS: Results from this study indicate that limiting pandemic-related online
information seeking may aid anxiety management in our study population. ©Parvati Singh, William G Cumberland, Dominic Ugarte, Tim-Allen Bruckner, Sean D Young. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 10.09.2020. |
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Siow, MY, Walker, et al |
Clin Orthop Relat Res |
Healthcare Response | Réponse des soins de santé |
Purpose: (1) To what extent did telehealth usage increase for an outpatient orthopaedic trauma clinic at a Level 1
trauma center from the month before the COVID-19 stay-at-home order compared with the month immediately following the order? (2) What is the proportion of no-show visits before and after the implementation of telehealth? |
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Sjödin, H, Johansson, et al |
Int J Epidemiol |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique Healthcare Response | Réponse des soins de santé |
Background: Sweden has taken a different approach aiming to mitigate, not suppress, community transmission, by using
physical distancing without lockdowns. |
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Smith, PM, Oudyk, et al |
Can J Psychiatry |
Public Health response| Interventions de santé publique |
This study aimed to examine the relationship between perceived adequacy of personal protective equipment (PPE) and
workplace-based infection control procedures (ICP) and mental health symptoms among a sample of health-care workers in Canada within the context of the current COVID-19 pandemic. A total of 7,298 respondents started the survey, of which 5,988 reported information
on the main exposures and outcomes. A total of 54.8% (95% CI], 53.5% to 56.1%) of the sample had GAD-2 scores of 3 and higher, and 42.3% (95% CI, 41.0% to 43.6%) of the sample had PHQ-2 scores of 3 and higher. Absolute differences of 18% (95% CI, 12% to 23%)
and 17% (95% CI, 12% to 22%) were observed in the prevalence of GAD-2 scores of 3 and higher between workers whose perceived PPE needs and ICP needs were met compared to those who needs were not met. Differences of between 11% (95% CI, 6% to 17%) and 19% (95%
CI, 14% to 24%) were observed in PHQ-2 scores of 3 and higher across these same PPE and ICP categories. |
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Snoeijer, BerberT, Burger, et al |
arXiv |
Public health interventions*| Interventions de santé publique |
The implementation of governmental Non-Pharmaceutical Interventions (NPIs) has been the primary means of controlling
the spread of the COVID-19. Using global mobility data, released by Apple and Google, and ACAPS NPI data, we investigate the proportional contribution of NPIs on i) size of the change (magnitude) of transition between pre- and post-lockdown mobility levels
and ii) rate (gradient) of this transition. Using generalized linear models to find the best fit model we found similar results using Apple or Google data. NPIs found to impact the magnitude of the change in mobility were: Lockdown measures (Apple, Google
Retail and Recreation (RAR) and Google Transit and Stations (TS)), declaring a state of emergency (Apple, Google RAR and Google TS), closure of businesses and public services (Google RAR) and school closures (Apple). Using cluster analysis and chi square tests
we found that closure of businesses and public services, school closures and limiting public gatherings as well as border closures and international flight suspensions were closely related. The implementation of lockdown measures and limiting public gatherings
had the greatest effect on the rate of mobility change. |
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Sobol, I, Yuzefpolskaya, et al |
J Card Fail |
Clinical data| Données cliniques |
The goal of this series was to share our experience with patients with left ventricular assist devices (LVADs) who
were diagnosed with COVID-19, with particular emphasis on their initial presentation, disease course, treatment management and final outcome. We retrospectively reviewed all adult patients with LVADs who are presently followed at two large centers in New
York City. |
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32921748; Newly-onset type 1 diabetes mellitus
precipitated by COVID-19 in an 8-month-old infant |
Soliman, AT, Al-Amri, et al |
Acta bio-medica : Atenei Parmensis |
Clinical data| Données cliniques |
Type 1 diabetes mellitus (T1DM) is rare in infants and toddlers and is usually associated with a relatively high mortality
when complicated with diabetic ketoacidosis (DKA). In infants, the classical symptoms of DKA are atypical and therefore many infants with DKA are mistreated for infections. We report a case of DKA precipitated by COVID-19 in an 8-month-old infant with newly
diagnosed diabetes mellitus. This case is reported in view of its rarity and originality. The relation between T1DM and COVID19 infection is discussed. |
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Soliman, AT, Prabhakaran Nair, et al |
Acta bio-medica : Atenei Parmensis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of the study was to describe and compare the clinical presentation and radiological and hematological
data of a cohort of symptomatic COVID19 positive T2DM diabetic patients (n = 59) versus another cohort of non-diabetic symptomatic COVID19 positive patients (n =244) diagnosed at the same time from January 2020 to May 2020. Prevalence of T2DM in symptomatic
COVID19 positive patients was 59/303 (=19.5%). Diabetic patients had higher prevalence of hypertension, chronic kidney disease (CKD) and cardiac dysfunction coronary heart disease (CHD)], and congestive heart failure (CHF). Charlson Comorbidity score was significantly
higher in the T2DM patients (2.4± 1.6) versus the non-diabetic -patients (0.28 ± 0.8; p: < 0.001). Clinically and radiologically, T2DM patients had significantly higher percentage of pneumonia, severe pneumonia and ARDS versus the non-diabetic patients. Hematologically,
diabetic patients had significantly higher C-reactive protein (CRP), higher absolute neutrophilic count (ANC) and lower counts of lymphocytes and eosinophils compared to non-diabetic patients. They had significantly higher systolic and diastolic blood pressures,
longer duration of hospitalization, ICU stay, mechanical ventilation and oxygen therapy. CRP was correlated significantly with the duration of stay in the ICU and the duration for oxygen supplementation (r = 0.37 and 0.42 respectively; p: <0.01). T2DM patients
showed higher inflammatory response to COVID 19 with higher absolute neutrophilic count (ANC) and CRP with lower lymphocytic and eosinophilic counts. |
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Impact of social support and social trust on public viral risk response: A COVID-19
survey study |
Song, E, Yoo, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
This study examined the impact of social support and social trust on the activities and efficacy of the public’s risk
response in the case of COVID-19. We conducted an online survey over eight days with 620 Korean adult participants. Data were analyzed using structural equation modelling and K-means cluster analysis. Our results showed that public support had a positive impact
on response efficacy, while response efficacy had a positive impact on sanitation, distancing, and purchasing activities. In addition, social support positively moderated the impact of public and individual support on response efficacy, while response efficacy
negatively moderated the impact on sanitation activities. These results suggest that governments should proactively supply tools and information for infection-prevention, and deliver messages that encourage and support infection-prevention activities among
the public; governments, along with all other members of society, must engage in aggressive risk response measures; and there is a need for risk communication that further emphasizes the importance of personal sanitation activities in the face of viral risk. |
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Soriano, JB, Fernández, et al |
JMIR Public Health Surveill |
Healthcare Response | Réponse des soins de santé |
We aimed to develop and test an effective and user-friendly tool to identify and track symptoms compatible with COVID-19
in hospital workers. We developed and pilot tested Hospital Epidemics Tracker (HEpiTracker), a newly designed app to track the spread of COVID-19 among hospital workers. Hospital staff in 9 hospital centers across 5 Spanish regions (Andalusia, Balearics, Catalonia,
Galicia, and Madrid) were invited to download the app on their phones and to register their daily body temperature, COVID-19-compatible symptoms, and general health score, as well as any polymerase chain reaction and serological test results. A total of 477
hospital staff participated in the study between April 8 and June 2, 2020. Of note, both health-related (n=329) and non-health-related (n=148) professionals participated in the study; over two-thirds of participants (68.8%) were health workers (43.4% physicians
and 25.4% nurses), while the proportion of non-health-related workers by center ranged from 40% to 85%. Most participants were female (n=323, 67.5%), with a mean age of 45.4 years (SD 10.6). Regarding smoking habits, 13.0% and 34.2% of participants were current
or former smokers, respectively. The daily reporting of symptoms was highly variable across participating hospitals; although we observed a decline in adherence after an initial participation peak in some hospitals, other sites were characterized by low participation
rates throughout the study period. |
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Soriano, MC, Vaquero, et al |
J Infect |
Clinical data| Données cliniques |
This letter to the editor includes retrospective data on patients who were admitted to the Intensive Care Departement
at the Hospital Universitario Ramón y Cajal in Madrid (Spain), with the primary diagnosis of SARS-COV-2 between March 10th and June 19th, 2020. A total of 83 patients were enrolled. Overall mortality in the ICU was 24.1 %. The incidence of bacterial coinfection
at admission was only 8.4% and no patient was diagnosed at admission with any other virus than SARS-CoV-2. Isolated bacteria were: S. pneumoniae n=1, Legionella pneumophila n=2, Pseudomonas aeruginosa n=1, Klebsiella oxytoca n=1 and Methicilin-sensitive S.
aureus n=2. These findings support stopping empirical antibiotics in the vast majority of patients when COVID-19 infection is confirmed. However, it is important to remark that mortality in the subgroup of patients with co-infection was very high, with a mortality
rate of 57.1% versus 21.1% in patient without co-infection (p = 0.033). |
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Impacts of COVID-19 on electronic cigarette purchasing, use and related behaviors |
Soule, EK, Mayne, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
This study examined impacts of COVID-19 on electronic cigarette (ECIG) users. Concept mapping, a mixed-methods approach,
was used to identify COVID-19 impacts on adult ECIG users. ECIG users (n= 93) provided statements completing a prompt: “A specific way Coronavirus/COVID-19 has affected my vaping/e-cigarette use, my vaping/e-cigarette related purchasing, or other vaping/e-cigarette
related behaviors or issues is…”. Participants generated 85 unique statements, sorted statements into groups of similar content and rated each statement on how true they were. Multidimensional scaling and hierarchical cluster analysis identified thematic clusters.
Mean cluster ratings were compared between sample subgroups. Ten clusters were identified: Stocking up and Bulk Purchasing, Challenges in Obtaining ECIG Supplies, Alternative Purchasing Procedures, Increased ECIG use, Disruption of Routine and ECIG Use, Efforts
to Decrease ECIG Use, Improving ECIG Skills, COVID-19 Health Concerns, Perceptions of ECIG Use and COVID-19, and COVID-19 Protection. More dependent ECIG users and dual users of ECIGs and cigarettes rated clusters higher than less dependent ECIG users and
non-dual users. ECIG users may experience or perceive they face additional COVID-19 impacts, such as increased exposure, financial burdens, stress, and health risks. |
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SARS-CoV-2 infection: physiological and environmental gift factors
at high altitude |
Srivastava, S, Garg, et al |
VirusDisease |
Epidemiology| Épidémiologie |
The present report is an attempt to study the effect of physiological and environmental factors existing at high altitudes
(HA) with spread of SARS-CoV-2 infection. Analysis of existing data revealed that HA natives do possess certain physiological advantages such as (1) improved hypoxic ventilatory response, (2) higher concentration of oxygen carrying molecules, haemoglobin,
(3) increased production of Vitamin D, due to intense solar radiation, (4) lower rates of comorbidities such as lung infections, obesity etc. and (5) most importantly reduced production of angiotensin converting enzyme 2, a carrier molecule for SARS-CoV-2
virus entry into the host cell; all of which can collectively account for improved tolerance to SARS-CoV-2 infection in HA natives. In addition, environmental factors at HA such as (6) dry and chilly winds, (7) low air density and (8) intense UV radiations
may further inhibit viral growth and spread into the atmosphere. High altitude natives may posses physiological and environmental advantage over low landers in terms of reduced severity of SARS-CoV-2 infection and its limited spread. |
|
Staehler, M, Battle, et al |
European Urology Focus |
Public Health response| Interventions de santé publique |
This study aims to ascertain renal cell carcinoma (RCC) patients’ perspectives on COVID-19 and understand the associated
implications for treatment. An online survey of RCC patients was conducted from March 22 to March 25, 2020, disseminated through social media and patient networking platforms. A total of 539 patients (male:female 39%:58%) from 14 countries responded. Of
them, 71% felt that their risk of COVID-19 infection was higher than the general population, and 27% contacted their physician to establish this. Among patients with localized disease (40%), most (42%) had scheduled surveillance scans within 6 wk–65% were
unwilling to delay scans. Among patients with metastatic disease, 76% were receiving active therapy. While most patients preferred not to defer therapy (51%), patients receiving immune therapy regimens were less amenable to deferring therapy than those receiving
targeted treatment (20% vs 47%). Many patients with RCC were inclined to adhere to existing schedules of surveillance (localized disease) and systemic treatment (metastatic disease). |
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Stang, A, Standl, et al |
J Infect |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
The aim of this study is to provide estimates of excess mortality in Germany during the first wave of SARS-CoV-2 (week
10 to 23 in 2020). We analyzed age-specific numbers of deaths per week from 2016 to week 26 in 2020. We used weekly mean numbers of deaths of 2016-2019 to estimate expected weekly numbers for 2020. We estimated standardized mortality ratios (SMR) and 95% confidence
intervals. The observed numbers of deaths were higher than expected for age groups 60-69, 80-89, and 90+. The age group 70-79 years did not show excess mortality. The net excess number of deaths for weeks 10-23 was +8,071. The overall SMR was 1•03 (95%CI
1•03-1•04). The largest increase occurred among people aged 80-89 and 90+ (SMR=1•08 and SMR=1•09). A sensitivity analysis that accounts for demographic changes revealed an overall SMR of 0•98 (95%CI 0•98-0•99) and a deficit of 4,926 deaths for week 10-23,
2020. |
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Inadequate prophylactic effect of low-molecular
weight heparin in critically ill COVID-19 patients |
Stattin, K, Lipcsey, et al |
Journal of critical care |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Purpose: The aim of this study was to investigate potential markers of coagulopathy and the effects of thromboprophylaxis
with low-molecular-weight heparin (LMWH) on thromboelastography (TEG) and anti-factor Xa in critically ill COVID-19 patients. Material and Methods: We conducted a prospective study in 31 consecutive adult intensive care unit (ICU) patients. TEG with and without
heparinase and anti-factor Xa analysis were performed. Standard thromboprophylaxis was given with dalteparin (75–100 IU/kg subcutaneously). Results: Five patients (16%) had symptomatic thromboembolic events. All patients had a maximum amplitude (MA) > 65 mm
and 13 (42%) had MA > 72 mm at some point during ICU stay. Anti-factor Xa activity were below the target range in 23% of the patients and above target range in 46% of patients. There was no significant correlation between dalteparin dose and anti-factor Xa
activity. Conclusions: Patients with COVID-19 have hypercoagulability with high MA on TEG. The effect of LMWH on thromboembolic disease, anti-factor Xa activity and TEG was variable and could not be reliably predicted. This indicates that standard prophylactic
doses of LMWH may be insufficient. Monitoring coagulation and the LMWH effect is important in patients with COVID-19 but interpreting the results in relation to risk of thromboembolic disease poses difficulties. © 2020 Elsevier Inc. |
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32901755; Dietary changes in the NutriNet Brasil cohort during the covid-19
pandemic |
Steele, EM, Rauber, et al |
Revista de saude publica |
Public Health response| Interventions de santé publique |
To describe the dietary characteristics of participants in the NutriNet Brasil cohort before and during the covid-19
pandemic. Participants (n = 10,116) were selected to complete a questionnaire on their diet at two time points: the first time when entering the study, between January 26 and February 15, 2020, and the second between May 10 and 19, 2020. The questionnaire
includes questions about the consumption of healthy (vegetables, fruits and legumes) and unhealthy (ultra-processed foods) eating markers. Comparisons of indicators based on the consumption of these markers before and during the pandemic are presented for
the study population and according to gender, age group, macro-region of residence and schooling. Chi-square tests and t-tests were used to compare proportions and means, respectively, adopting p < 0.05 to identify significant differences. For all participants,
we found a modest but statistically significant increase in the consumption of healthy eating markers and stability in the consumption of unhealthy food markers. This favorable pattern of dietary changes during the pandemic occurred in most sociodemographic
strata. We observed a less favorable changing pattern, with a tendency to increasing consumption of healthy and unhealthy food markers, in the Northeast and North macro-regions and among people with less schooling, suggesting social inequalities in the response
to the pandemic. |
|
Steenbergen, DJ, Neihapi, et al |
Marine Policy |
Public Health response| Interventions de santé publique |
To understand how coastal communities in Vanuatu were impacted in the immediate period after COVID-19 measures were
placed, and how people responded to the changing circumstances, a rapid appraisal survey was carried out following a nationally declared state of emergency in March 2020. Results reveal changes in village population, loss of cash income, difficulties in accessing
food and shifting pressures on particular resources and habitats. The findings provide insights into the ways local adaptive capacity to satisfy livelihood and food security needs differed among rural contexts. |
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Stivanello, E, Perlangeli, et al |
Acta bio-medica : Atenei Parmensis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Our aim is to describe sociodemographic and transmission profile of COVID-19 cases that were transmitted before and
after the introduction of the decree in the Bologna Local Health Authority. Cases were classified as transmitted before or after the decree according to the date of last contact with a COVID-19 case or, if this date was unavailable, we used the date of onset
of symptoms considering the incubation period. Sociodemographic, clinical and epidemiological information was collected by using the infectious disease monitoring database, hospital discharge, deprivation index and long term care facility databases. In the
period after the publication of the decree, there were more elderly, females, strangers, retired, residents in nursing homes and deprived people than in the first period. There were also more health care personnel and less professionals/managers, sales or
office workers. In both phases, family is mentioned as the first community attended although less frequently in the second group. The profile of the new COVID-19 cases changed during the outbreak suggesting a differential effect of lockdown measures on the
population. |
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Suffoletto, B, Ram, et al |
Journal of Adolescent Health |
Public Health response| Interventions de santé publique RCT |
This study explored adherence to "stay-at-home" (SAH) orders by young adults with hazardous drinking, and the role
of alcohol consumption with in-person contacts on adherence. Analyses included young adults with hazardous drinking (i.e., AUDIT-C score ≥3/4 for women/men; n = 50; ages 18–25) participating in a randomized trial in Pittsburgh, PA. Participants provided experience
sampling reports on drinking twice per week from the week before SAH orders started on April 1, 2020 through 6 weeks during the SAH period. We examined how in-person contact with non-household friends changed over time and event-level relationships between
alcohol consumption and in-person contacts. Results: The percentage of participants with any in-person contact in the week before SAH was 44% (95% confidence interval CI] 30%–59%), which decreased to 29% (95% CI 15%–43%) in the first SAH week and increased
to 65% (95% CI 46%–85%) by SAH week 6. Controlling for average levels of alcohol consumption, on days when young adults drank, participants reported more in-person contacts compared to nondrinking days. Preliminary data indicate that, among young adults with
hazardous drinking, adherence to public policies like SAH orders is suboptimal, declines over time, and is associated with drinking events. |
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Qualitative study of the psychological experience of COVID-19
patients during hospitalization |
Sun, N, Wei, et al |
Journal of affective disorders |
Public Health response| Interventions de santé publique |
This study aims to explore the psychology of COVID-19 patients during hospitalization. A phenomenological and robust
sampling approach was employed. Sixteen patients admitted to the First Affiliated Hospital of Henan University of Science and Technology with COVID-19 from 20th January to 1st March 2020 were selected. Data were collected through semi-structured interviews,
phone calls, or face-to-face interviews using quarantine measures. Data were analyzed using the Colaizzi method. The psychological experience of COVID-19 patients during hospitalization could be summarized into five themes. Firstly, attitudes toward the disease
included fear, denial, and stigma during the early stages, which gradually developed into acceptance in the later stages. Secondly, the major source of stress included the viral nature of the disease, quarantine measures, and concerns regarding the health
of family members. Thirdly, reactions of body and mind included disease stage-dependent emotional responses, excessive attention to symptoms, rumination, and changes in diet, sleep, and behavior. Fourthly, supportive factors included psychological adjustments,
medical care, and family and social support. Finally, the disease resulted in psychological growth and patients viewed problems with gratitude through the cherishing of life, family, bravery, and tenacity. |
|
Sun, X, Wandelt, et al |
J Air Transp Manag |
Public Health response| Interventions de santé publique |
In this study, we investigate the impact of COVID-19 on global air transportation at different scales, ranging from
worldwide airport networks where airports are nodes and links between airports exist when direct flights exist, to international country networks where countries are contracted as nodes, and to domestic airport networks for representative countries/regions.
We focus on the spatial-temporal evolutionary dynamics of COVID-19 in air transportation networks. Our study provides a comprehensive empirical analysis on the impact of the COVID-19 pandemic on aviation from a complex system perspective using network science
tools. |
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Can questions summarize a corpus? Using question generation for characterizing COVID-19 research |
Surita, Gabriela, Nogueira, et al |
arXiv |
Public Health response| Interventions de santé publique |
This article describes a method, corpus2question, used to aggregate a large amount of data on texts related to COVID.
Results show that applying corpus2question on a corpus of scientific articles related to COVID-19 yields relevant questions about the topic. The most frequent questions are "what is covid 19" and "what is the treatment for covid". Among the 1000 most frequent
questions are "what is the threshold for herd immunity" and "what is the role of ace2 in viral entry". The authors demonstrate that the proposed method generated similar questions for 13 of the 27 expert-made questions from the CovidQA question answering dataset. |
|
Suzuki, Y, Maeda, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
We aimed to (1) assess how public health restrictions impact physical activity (PA), subjective well-being (SWB), and
health-related quality of life (HRQoL) of community-dwelling elderly, and (2) investigate risk factors that lead to a decline in PA. Self-administered questionnaires assessed the changes in PA, SWB, HRQoL. Multivariate logistic regression analysis was performed
to identify significant associated risk factors for decreased PA. Of 165 participants (valid response rate, 41.3%; mean age, 78.5 ± 8.0 years), 47.3% became less active, 23.0% became more active, and 29.7% maintained PA levels. There was a significant decrease
in SWB at baseline and follow-up after COVID-19 restrictions in the less active group (p < 0.01). Higher levels of moderate or strenuous exercise/sports activity at baseline (odds ratio OR], 1.12; 95% confidence interval CI], 1.01–1.24), and lower mental component
HRQoL scores at baseline (OR, 0.96; 95% CI, 0.93–0.99) were associated with an increased risk of decreased PA. Public health restrictions impact the PA of the elderly, especially those who had higher levels of exercise/sports activity and lower HRQoL before
COVID-19. |
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Suzuki, YJ |
Medical hypotheses |
Coronavirology| Coronavirologie |
This article describes the hypothesis of the viral protein fragment theory of COVID-19 pathogenesis, based on observations
in cultured human vascular cells that SARS-CoV-2 spike protein can activate cell signaling events without the rest of the viral components. It is generally thought that SARS-CoV-2 and other single-stranded RNA viruses attach to the host cells through the interactions
between surface proteins of the viral capsid and the host cell receptors; the fusion and the entry of the viral components, resulting in the replication of the viruses; and the host cell responses are the consequence of these events. |
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COVID-19 Lockdown and Its Adverse Impact on Psychological
Health in Breast Cancer |
Swainston, J, Chapman, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
We aimed to explore the effect of disruption to scheduled oncology services and the UK Government shielding letter
on emotional and cognitive vulnerability and to investigate the relationship between COVID-19 related emotional vulnerability (COVID-EMV) and anxiety, depression and perceived cognitive function. Women diagnosed with primary breast cancer (N = 234) completed
a series of online questionnaires to assess their cognitive and emotional wellbeing as well as their COVID-EMV. Results indicated that disrupted oncology services had a significant impact on COVID-EMV, anxiety and depression, with those experiencing disruptions
expressing higher general emotional vulnerability as well as COVID-EMV. Further, the UK Government letter had a significant effect on perceived cognitive function; those who received the letter reported poorer cognitive function. Regression analyses revealed
that after allowing for the effects of sociodemographic and clinical variables, women’s COVID-EMV significantly predicted worse outcomes of anxiety, depression and perceived cognitive function. Our findings indicate that concerns about COVID-19 amongst women
affected by breast cancer leads to increased risk of developing affective disorder, such as anxiety and depression symptomatology, among this sample. |
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Critical Interactions Between the SARS-CoV-2 Spike
Glycoprotein and the Human ACE2 Receptor |
Taka, Elhan, Yilmaz, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human cells upon binding of its spike (S) glycoproteins
to ACE2 receptors and causes the Coronavirus disease 2019 (COVID-19). Therapeutic approaches to prevent SARS-CoV-2 infection are mostly focused on blocking S-ACE2 binding, but critical residues that stabilize this interaction are not well understood. By performing
all-atom Molecular Dynamics (MD) simulations, we identified an extended network of salt bridges, hydrophobic and electrostatic interactions, and hydrogen bonding between the receptor-binding domain (RBD) of the S protein and ACE2. Mutagenesis of these residues
on the RBD was not sufficient to destabilize binding but reduced the average work to unbind the S protein from ACE2. In particular, the hydrophobic end of RBD serves as the main anchor site and unbinds last from ACE2 under force. We propose that blocking this
site via neutralizing antibody or nanobody could prove an effective strategy to inhibit S-ACE2 interactions.Competing Interest StatementThe authors have declared no competing interest. |
|
Critical Interactions Between the SARS-CoV-2 Spike
Glycoprotein and the Human ACE2 Receptor |
Taka, Elhan, Yilmaz, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human cells upon binding of its spike (S) glycoproteins
to ACE2 receptors and causes the Coronavirus disease 2019 (COVID-19). Therapeutic approaches to prevent SARS-CoV-2 infection are mostly focused on blocking S-ACE2 binding, but critical residues that stabilize this interaction are not well understood. By performing
all-atom Molecular Dynamics (MD) simulations, we identified an extended network of salt bridges, hydrophobic and electrostatic interactions, and hydrogen bonding between the receptor-binding domain (RBD) of the S protein and ACE2. Mutagenesis of these residues
on the RBD was not sufficient to destabilize binding but reduced the average work to unbind the S protein from ACE2. In particular, the hydrophobic end of RBD serves as the main anchor site and unbinds last from ACE2 under force. We propose that blocking this
site via neutralizing antibody or nanobody could prove an effective strategy to inhibit S-ACE2 interactions.Competing Interest StatementThe authors have declared no competing interest. |
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Tamaki, M, Nakasone, et al |
Biology of Blood and Marrow Transplantation |
Healthcare Response | Réponse des soins de santé |
The pulmonary function test (PFT) is an important test for risk stratification before allogeneic transplantation (allo-HCT).
However, it might be preferable to avoid PFT as much as possible in the recent era of coronavirus disease 2019 (COVID-19), because PFT requires forced expirations and might produce aerosols, increasing the risk of COVID-19 transmission. Therefore, we tried
to predict normal PFT results before allo-HCT based on computed tomography (CT) findings. This study included 390 allo-HCT recipients at our center for whom lung CT images and PFT results before allo-HCT were available. Abnormal CT findings were less likely
to be observed in the normal PFT group (47.0% versus 67.4%, P = .015), with a high negative predictive value of 92.9%. In a multivariate analysis, normal CT was significantly associated with normal PFT (odds ratio, 2.47; 95% confidence interval, 1.22 to 4.97;
P = .012). A model for predicting normal PFT was constructed based on the results of a multivariate analysis, and the area under the curve of the receiver operating characteristic analysis was 0.656, which gave a sensitivity of 45.5% and a specificity of 86.0%.
The relatively high specificity of the model suggested that PFT can be omitted in patients with normal CT findings before allo-HCT. © 2020 American Society for Transplantation and Cellular Therapy |
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32914093;
Public Compliance with Face Mask Use in Honolulu and Regional Variation |
Tamamoto, KA, Rousslang, et al |
Hawai'i journal of health & social welfare |
Public Health response| Interventions de santé publique |
The authors performed an observational study at 2 locations in Honolulu and evaluated outdoor face mask use compliance
in 200 people. Simultaneous observations were performed in a downtown Honolulu business area and in Waikiki, an area focusing on tourism. Overall, 77% of all subjects used face masks in an appropriate fashion, covering their nose and mouth, while 23% were
either incorrectly masked or not masked. The rate of compliance with correct public mask use in downtown Honolulu (88%) was significantly higher than in Waikiki (66%) (P=.0003, Odds Ratio 95% Confidence Interval]=3.78 1.82, 7.85]) These findings suggest that
there are opportunities for improvement in rates of public face mask use and a potential decrease in the spread of COVID-19 in our population. |
|
Tang, L, Zhou, et al |
Chinese Journal of Radiological Medicine and Protection |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
Objective: To survey and supervise the risk of infection control and radiation safety in the radiological diagnostic
workplace for COVID-19, and provide data support for the safety protection of radiographers and related staff.
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Tang, Z, Dubois, et al |
J Telemed Telecare |
Healthcare Response | Réponse des soins de santé |
This study describes the experience with a hybrid gastroenterology electronic consultation programme starting in 2019.
Electronic consultations were performed for every referral regardless of indication as well as directly initiated telephone-based telehealth visits with patients without the need for in-person clinic. Over five consecutive months, 1243 hybrid electronic consultations
were performed with 356 (29%) resulting in a clinic appointment. The remaining 887 (71%) electronic consultations were resolved without need for a clinic visit. Five hundred and fourteen (41%) electronic consultations resulted in a directly scheduled procedure
without clinic appointment. Eighty-five per cent of electronic consultations were performed on the same day of referral and 98% of electronic consultations were completed in under 20 min. A hybrid electronic consultation model which pre-emptively reviews all
outpatient referrals streamlines access to specialty care. |
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Are mouse and cat the missing link in the COVID-19 outbreaks in seafood markets? |
Tao, DanielH, Sun, et al |
arXiv |
Coronavirology| Coronavirologie |
Virus host-genome similarity (HGS) is an important factor that reflects the adaptability of virus to host. SARS-CoV-2
may retain beneficial mutations to increase HGS and evade the host immune system. This study investigated the HGSs between 399 SARS-CoV-2 strains and 10 hosts of different species, including bat, mouse, cat, swine, snake, dog, pangolin, chicken, human and
monkey. The results showed that the HGS between SARS-CoV-2 and bat was the highest, followed by mouse and cat. Human and monkey had the lowest HGS values. In terms of genetic similarity, mouse and monkey are halfway between bat and human. These findings suggest
that animals closely related to human life, especially those with high HGS, need to be closely monitored. |
|
Taquechel, K, Diwadkar, et al |
Journal of Allergy and Clinical Immunology: In Practice |
Public Health response| Interventions de santé publique |
Objective: We sought to identify changes in pediatric asthma-related health care utilization, respiratory viral testing,
and air pollution during the COVID-19 pandemic. |
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|
Tasa, D, Eslami, et al |
Acta bio-medica : Atenei Parmensis |
Healthcare Response | Réponse des soins de santé |
ackground: During the pandemic of COVID-19, the overwhelm of infected patients created an exponential surge for ICU
and ward beds. As a result, a major proportion of elective surgeries was postponed. However, various emergency and urgent procedures were allowed. Due to the mortality complications of hepatopancreatobiliary issues, we decided to afford urgent procedures under
intensive protective arrangements. Method and results: In our ward (liver transplant), 4 ICU beds and 16 ward beds were allocated to non-COVID-19 patients. A total of 36 hepatopancreatobiliary procedures were managed for one month. All the surgeries were afforded
under personal protective equipment and other intensive protective arrangements for personnel and patients. During 6 weeks following the surgery, all patients were followed up through telemedicine and no new case of COVID-19 was detected. Conclusion: In general,
it appears that intensive protections could significantly reduce the number of COVID-19 incidence among patients with co-morbidities who undergo invasive procedures. |
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Team, Covid- National Incident Room Surveillance |
Communicable diseases intelligence (2018) |
Epidemiology| Épidémiologie Surveillance |
This is a summary of the epidemiological data in Australia related to COVID-19. Cumulatively to 30 August there have
been 25,686 case notifications and 577 deaths. The number of new cases reported nationally this fortnight was 1,751, a 61% decrease from the previous fortnight (4,501). On average this represented 125 cases diagnosed each day over the reporting period, a
decrease from 322 cases per day over the previous reporting period. The majority of new cases 94% (1,640) were reported in Victoria, with a smaller number of cases reported from New South Wales (86), Queensland (19), Western Australia (5) and South Australia
(1). The continued decrease in new cases observed this fortnight in Victoria is likely associated with the enhanced public health measures that are currently in place in Victoria. Locally acquired cases which were predominantly associated with several interconnected
clusters continued to be reported in NSW. A total of 26 deaths were reported from cases diagnosed in this reporting period, all from Victoria and aged 75 years or older. Testing rates remain high across all jurisdictions, with an overall positivity rate for
the reporting period of 0.27%. Victoria reported a positivity rate of 0.90% for this reporting period; in all other jurisdictions the positivity rate was 0.03% or lower. |
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Tebé, C, Valls, et al |
BMC Med Res Methodol |
Epidemiology| Épidémiologie Surveillance |
BACKGROUND: Data analysis and visualization is an essential tool for exploring and communicating findings in medical
research, especially in epidemiological surveillance. RESULTS: Data on COVID-19 diagnosed cases and mortality, from January 1st, 2020, onwards is collected automatically from the European Centre for Disease Prevention and Control (ECDC). We have developed
a Shiny application for data visualization and analysis of several indicators to follow the SARS-CoV-2 epidemic using ECDC data. A country-specific tool for basic epidemiological surveillance, in an interactive and user-friendly manner. The available analyses
cover time trends and projections, attack rate, population fatality rate, case fatality rate, and basic reproduction number. CONCLUSIONS: The COVID19-World online web application systematically produces daily updated country-specific data visualization and
analysis of the SARS-CoV-2 epidemic worldwide. The application may help for a better understanding of the SARS-CoV-2 epidemic worldwide. |
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Impact of lung segmentation on the diagnosis and explanation of COVID-19 in chest X-ray images |
Teixeira, LucasO, Pereira, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The objectives are to demonstrate the impact of lung segmentation in COVID-19 automatic identification using CXR images
and evaluate which contents of the image decisively contribute to the identification. We have performed lung segmentation using a U-Net CNN architecture, and the classification using three well-known CNN architectures: VGG, ResNet, and Inception. To estimate
the impact of lung segmentation, we applied some Explainable Artificial Intelligence (XAI), such as LIME and Grad-CAM. To evaluate our approach, we built a database named RYDLS-20-v2, following our previous publication and the COVIDx database guidelines. We
evaluated the impact of creating a COVID-19 CXR image database from different sources, called database bias, and the COVID-19 generalization from one database to another, representing our less biased scenario. The experimental results of the segmentation achieved
a Jaccard distance of 0.034 and a Dice coefficient of 0.982. In the best and more realistic scenario, we achieved an F1-Score of 0.74 and an area under the ROC curve of 0.9 for COVID-19 identification using segmented CXR images. Further testing and XAI techniques
suggest that segmented CXR images represent a much more realistic and less biased performance. |
|
COVID-19 Pandemic in Assisted Living Communities: Results from Seven
States |
Temkin-Greener, H, Guo, et al |
J Am Geriatr Soc |
Epidemiology| Épidémiologie |
OBJECTIVE: To describe variations in COVID-19 confirmed cases and deaths among assisted living (AL) residents and examine
their associations with key AL characteristics. |
|
Tezcan, ME, Dogan Gokce, et al |
New Microbes and New Infections |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
In this study, we assessed the validity of the hypothesis that baseline electrolyte imbalances may be related to unfavourable
outcomes in hospitalized COVID-19 patients. This was a retrospective observational study, which included 408 hospitalized individuals with COVID-19 over 18 years old. Baseline levels of sodium, potassium, calcium and chloride were assessed and the effects
of abnormalities in these electrolytes on requirement for intensive care unit and mechanical ventilation, hospitalization duration and treatment outcome were evaluated. Patients were clustered based on electrolyte levels and clusters were compared according
to outcome variables. Frequency of other severe disease indices was compared between the clusters. Independent factors related to COVID-19-associated deaths were also evaluated using multivariate analyses. 228 (55.8%) of the patients had at least one electrolyte
imbalance at baseline. Hyponatraemia was the most frequent electrolyte abnormality. Patients with hyponatraemia, hypochloraemia or hypocalcaemia had, respectively, more frequent requirement for intensive care unit and mechanical ventilation, higher mortality
rate and longer hospitalization. The clusters associated with electrolyte abnormalities had unfavourable outcomes. Hyponatraemia was an independent factor related to death from COVID-19 (OR 10.33; 95% CI 1.62–65.62; p 0.01). Furthermore, baseline electrolyte
imbalances, primarily hyponatraemia, were related to poor prognosis in COVID-19 and baseline electrolyte assessment would be beneficial for evaluating the risk of severe COVID-19. |
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|
Therchilsen, JH, von Buchwald, et al |
Diagnostics |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The aim of this study was to compare the sensitivity of self-collected versus healthcare worker (HCW)-collected swabs
for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) testing. A total of 109 participants were included, and 19 participants had SARS-CoV-2-positive results. The diagnostic sensitivity of the self-collected and HCW-collected swabs was 84.2% and
89.5%, respectively. Further, results from a questionnaire answered by the participants found that loss of smell as a self-reported symptom was a strong predictor for a SARS-CoV-2-positive test. |
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Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein |
Toelzer, C, Gupta, et al |
Science |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
COVID-19, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), represents a global crisis. Key to
SARS-CoV-2 therapeutic development is unraveling the mechanisms driving high infectivity, broad tissue tropism and severe pathology. Our 2.85 Å cryo-EM structure of SARS-CoV-2 spike (S) glycoprotein reveals that the receptor binding domains (RBDs) tightly
bind the essential free fatty acid (FFA) linoleic acid (LA) in three composite binding pockets. The pocket also appears to be present in the highly pathogenic coronaviruses SARS-CoV and MERS-CoV. LA binding stabilizes a locked S conformation giving rise to
reduced ACE2 interaction in vitro. In human cells, LA supplementation synergizes with the COVID-19 drug remdesivir, suppressing SARS-CoV-2 replication. Our structure directly links LA and S, setting the stage for intervention strategies targeting LA binding
by SARS-CoV-2. |
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Premature infant born to a convalescent mother with COVID-19 in mid-term
pregnancy |
Tong, C, Wang, et al |
Chinese Journal of Perinatal Medicine |
Transmission Clinical data| Données cliniques |
We report a female infant born preterm at 35 gestational weeks and four days to a woman who had been diagnosed with
COVID-19 at 26+6 weeks of pregnancy. Throat swab specimens obtained from the infant on the 2nd, 3rd and 8th day after birth for SARS-Cov-2 RNA detection were all negative. On the 2nd and 8th day after birth, SARS-Cov-2 IgM in the neonatal serum were negative,
while elevated IgG levels were observed, suggesting that the infant's IgG antibody of SARS-CoV-2 may have come from the mother. According to this case report, no intrauterine vertical transmission was found in the pregnancy with SARS-CoV-2 infection in the
second trimester. |
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PMC7486182; COVID-19-associated sleep disorders: A case report |
Tony, AA, Tony, et al |
Neurobiol Sleep Circadian Rhythms |
Clinical data| Données cliniques |
We reported one patient infected with acute respiratory syndrome coronavirus-2 (SARS-CoV-2) presented with sleep disorders;
insomnia and restless leg syndrome. The era of sleep disorders spectrum in patients with COVID-19 remains to be characterized suggesting a frightening scientific association between COVID-19 and neuropsychiatric illness. |
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Toussie, D, Voutsinas, et al |
Radiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Analyzed the prognostic value of a chest radiograph severity scoring system for younger (nonelderly) patients with
COVID-19. Each patient's emergency department (ED) chest radiograph was divided into six zones and examined for opacities by two cardiothoracic radiologists, and scores were collated into a total concordant lung zone severity score. Multivariable logistic
regression was used to evaluate the relationship between clinical parameters, chest radiograph scores, and patient outcomes. Independent predictors of hospital admission were chest radiograph severity score of 2 or more and obesity. Among patients who were
admitted, a chest radiograph score of 3 or more was an independent predictor of intubation. |
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Trabaud, MA, Icard, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Compared the performance of assays detecting IgG or total antibodies to N or S antigens, validated for routine use
in France, with samples from subjects with more or less severe SARS-CoV-2 infection. The positivity rate varied depending on the assay but was greater for all assays in hospitalized than non-hospitalized patients. Despite a good correlation between the assays,
discrepancies occurred, without a systematic origin, even for samples taken more than 20 days after symptom onset. These discrepancies were linked to low antibody levels in pauci-symptomatic patients. Whichever assay is chosen, a false negative result may
need to be ruled out with another test in a risk situation. |
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Tran, M, Sheth, et al |
Thrombosis Journal |
Clinical data| Données cliniques |
We describe a patient with SARS-CoV-2 pneumonitis who presented with intermediate risk pulmonary embolism (PE). His
daily platelet count suggested the possibility of immune mediated heparin-induced thrombocytopenia (HIT) which was confirmed by laboratory testing and resolved with a direct thrombin inhibitor. This case underscores the need to consider that thrombocytopenia
in patients with SARS-CoV-2 may be unrecognized HIT. |
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Trevenzoli, M, Guarnaccia, et al |
Journal of gastrointestinal and liver diseases : JGLD |
Clinical data| Données cliniques |
Describe a case of acute hepatocellular hepatitis related to COVID-19 and our experience. In our experience, liver
function tests (LFTs) abnormalities are commonly seen in COVID-19 patients. From February to June 2020, 309 patients have been hospitalized for COVID-19 in our department (61% males, mean age 61). Mild or moderate LFTs alterations have been detected in 4-10%
of the patients, while severe elevations were never found at the time of hospitalization. It is reasonable to assume that the hepatic alterations encountered in COVID-19 patients are multifactorial. However, the virus itself could also be responsible for a
direct cytopathic effect that can eventually lead to a clinical picture of acute hepatitis, a phenomenon called viral sepsis. |
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Hypokalemia in hospitalized patients with pneumonia associated with COVID-19 |
Tsiberkin, AI, Klyaus, et al |
Arterial Hypertension (Russian Federation) |
Clinical data| Données cliniques |
Article in Russian. Assessed the frequency of hypokalemia among hospitalized patients with pneumonia caused by COVID-19
and its relationship with the severity of the disease. Our results showed a high incidence of hypokalemia in hospitalized patients with pneumonia caused by COVID-19. Hypokalemia was positively associated with higher percentage of lung tissue damage and the
levels of acute phase proteins. |
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Turnšek, M, Brumen, et al |
Academica Turistica |
Public Health response| Interventions de santé publique |
Study provides first insights into Slovenian tourists’ perceived threats of covid-19 on two dimensions: severity and
susceptibility. The results have shown that age affects the two measured dimensions of perceived threat and future travel avoidance, but only with women. Furthermore, people who have travelled the most in the past express the least likelihood of avoidance
to travel due to the covid-19 pandemic. Those who are more educated, on the other hand, perceive higher risk, yet education has no role in their expressed future travel avoidance. The results, moreover, show that the moral obligation towards taking care of
others might be a highly important element in the success factor of covid-19 measures. Finally, the results show that we cannot easily predict how the general population will behave regarding their future travel avoidance since the opinions are not polarised
in the extremes. |
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Ufuk, F, Demirci, et al |
European Journal of Radiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Assessed the prognostic value of pneumonia severity score (PSS), pectoralis muscle area (PMA), and index (PMI) on chest
computed tomography (CT) in adult coronavirus disease 2019 (COVID-19) patients. The relationship between clinical variables, PSS, PMA, sex-specific PMI values, and patient outcomes (intubation, prolonged hospital stay, and death) were investigated. Patients
with comorbidity had a higher mean of PSS (6.3 + 4.5 vs 3.9 + 3.8; p = 0.001). After adjusting the confounders, PSS was an independent predictor of intubation, prolonged hospital stay, and death. PMI value was a predictor of prolonged hospital stay and death.
Incrementally increasing PMA value was a predictor of prolonged hospital stay and intubation. PSS, PMA, and PMI values have prognostic value in adult COVID-19 patients and can be easily assessed on chest CT images. |
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Umeizudike, KA, Isiekwe, et al |
J Dent Educ |
Healthcare Response | Réponse des soins de santé |
Assessed the knowledge, perception, and attitude of undergraduate dental students in Nigeria to the COVID-19 pandemic
and infection control practices. Fifty percent of the students had adequate knowledge of COVID-19. Final-year students (58.1%) demonstrated more adequate knowledge of COVID-19 than penultimate-year students (28.6%, P = 0.008). Most (95.1%) respondents had
positive attitudes towards infection control practices against COVID-19. Guidelines on COVID-19 from reputable health authorities should be reviewed by dental school authorities and disseminated to the students to suit their clinical practice. |
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Machine learning and classical forecasting methods based decision support systems
for covid-19 |
Ünlü, R, Namli, et al |
Computers, Materials and Continua |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
From late 2019 to the present day, the coronavirus outbreak tragically affected the whole world and killed tens of
thousands of people. Many countries have taken very stringent measures to alleviate the effects of the coronavirus disease 2019 (COVID-19) and are still being implemented. In this study, various machine learning techniques are implemented to predict possible
confirmed cases and mortality numbers for the future. According to these models, we have tried to shed light on the future in terms of possible measures to be taken or updating the current measures. Support Vector Machines (SVM), Holt-Winters, Prophet, and
Long-Short Term Memory (LSTM) forecasting models are applied to the novel COVID-19 dataset. According to the results, the Prophet model gives the lowest Root Mean Squared Error (RMSE) score compared to the other three models. Besides, according to this model,
a projection for the future COVID-19 predictions of Turkey has been drawn and aimed to shape the current measures against the coronavirus. © 2020 Tech Science Press. All rights reserved. |
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Recover Wisely From COVID-19: Responsible Resumption of Nonurgent Radiology Services |
Vagal, A, Mahoney, et al |
Academic Radiology |
Healthcare Response | Réponse des soins de santé |
Authors report their practice implementation and experience of COVID-19 recovery during the resumption of routine imaging
at a tertiary academic medical center. Used scheduling simulations and meticulous monitoring and control of outpatient medical imaging volumes to achieve a linear restoration to our pre-COVID imaging studies. Used a tiered plan to address the backlog of rescheduled
patients with gradual opening of our imaging facilities, while maintaining broad communication with our patients and referring clinicians. Outpatient growth was linear with an increase of approximately 172 cases per week, (R2 =0.97). Achieved an overall recovery
of 102% in week 10, as compared to average weekly pre-COVID outpatient volumes. |
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Vandercam, G, Simon, et al |
J Hosp Infect |
Clinical data| Données cliniques Immunology | Immunologie |
Analysed the clinical characteristics, humoral immune response, sources of contamination, and outcomes among healthcare
workers (HCW)s with COVID-19. Median delay between onset of symptoms and diagnosis was 4.39 days. Most frequent symptoms were cough and headache (75% respectively). Fever accounted for 68.7%. Most represented professions were nurses (42%). HCWs were mainly
infected by patient contact (32.9%). 7.6% required hospitalization and 1.7% were admitted in intensive care unit. Unfortunately, one HCW died (0.5 %). Total antibodies were positive in 109/126 (86.5%). Clinical presentation of COVID-19 in HCWs does not differ
from the general population. However outcomes were more favourable with a mortality rate lower than that reported in Belgian COVID-19 patients in general. |
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Rapid detection of inter-clade recombination in SARS-CoV-2
with Bolotie |
Varabyou, Ales, Pockrandt, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Previous methods for detecting recombination and reassortment events cannot handle the computational requirements of
analyzing tens of thousands of genomes, a scenario that has now emerged in the effort to track the spread of the SARS-CoV-2 virus. Furthermore, the low divergence of near-identical genomes sequenced in short periods of time presents a statistical challenge
not addressed by available methods. In this work we present Bolotie, an efficient method designed to detect recombination and reassortment events between clades of viral genomes. We applied our method to a large collection of SARS-CoV-2 genomes and discovered
hundreds of isolates that are likely of a recombinant origin. |
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32888905; Saliva is a reliable, non-invasive specimen for SARS-CoV-2 detection |
Vaz, SN, Santana, et al |
Brazilian Journal of Infectious Diseases |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Validated the use of saliva as a biological sample for diagnosis of COVID-19. Participants presenting with signs/symptoms
suggesting SARS-CoV-2 infection underwent a nasopharyngeal swab (NPS) and/or oropharyngeal swab (OPS), and saliva collection. The sensitivity and specificity of RT-PCR using saliva samples were 94.4% (95% CI 86.4–97.8) and 97.62% (95% CI 91.7–99.3), respectively.
There was an overall high agreement (96.1%) between the two tests. Use of self-collected saliva samples is an easy, convenient, and low-cost alternative to conventional NP swab-based molecular tests. |
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Vechi, HT, Maia, et al |
Revista do Instituto de Medicina Tropical de Sao Paulo |
Clinical data| Données cliniques |
In late 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged as the cause of a cluster of
pneumonia cases in China, and the corresponding disease was designated as Coronavirus Disease 2019 (COVID-19), spreading quickly around the world resulting in a pandemic. COVID-19 is associated with a set of coagulation abnormalities that increase the risk
of thromboembolic events, especially in patients with severe/critical disease. We describe a series of five cases of mild COVID-19, treated in an outpatient clinic, which, after an apparent clinical improvement, developed acute pulmonary embolism (APE) between
the third and the fourth week after the onset of symptoms, when they are mostly related to acute illness disappearance. Thromboembolic events are also a potential complication of mild COVID-19 and can manifest later in the disease course. This finding raises
discussion about the prevention of thromboembolic events in selected group of patients with mild COVID-19. |
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Vee, ST, Muhamad, et al |
Medical Journal of Malaysia |
Clinical data| Données cliniques |
Describes the clinical characteristics of COVID-19 patients admitted to Hospital Tengku Ampuan Afzan (HTAA), Pahang,
Malaysia and to identify the clinical and laboratory markers for severe disease, complications and virologic clearance according to clinical staging. Data obtained from the medical report includes baseline characteristics of patients, comorbidities, presenting
symptoms, laboratory findings, treatments, complications, and outcomes. The majority of hospitalizations consisted at clinical-stage 1 (43%) and stage 2 (39%) disease. Older patients, diabetes mellitus, hypertension, cardiovascular diseases, and chronic kidney
disease were found more common among patients with severe disease. Pneumonia was mostly diagnosed radiologically using chest radiography, especially among clinical stage 3. Acute kidney injury (AKI) was a significant complication, with 31% of clinical stage
3 and above developing AKI. |
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32912089; Bilateral Acute Lower Limb Ischemia Secondary to COVID-19 |
Veerasuri, S, Kulkarni, et al |
Vascular and Endovascular Surgery |
Clinical data| Données cliniques |
COVID-19 has to date affected over 5 million people worldwide and caused in excess of 300000 deaths. One of the principal
finding is that of a thrombotic tendency within the lungs leading to high mortality. There have been increasing number of reports of peripheral arterial thrombosis as well. Most cases of arterial thrombosis is noted in patient in intensive care setting. Here-in
we report a case of acute bilateral lower limb arterial thrombosis in a patient recovering at home with mild COVID-19 symptoms, highlighting that patients with milder symptoms may also suffer from prothrombotic state resulting in acute arterial occlusions.
Arterial thrombosis should be suspected in these patients despite the absence of predisposing factors. © The Author(s) 2020. |
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Verma, Devvret, Mitra, et al |
Research Square prepub |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The rapid spread of SARS-CoV-2 has raised a severe global public health issue, where therapy is not identified with
specific drugs or vaccines. The present investigation dealt with the inhibition of various proteins and receptors of virus using phytocompounds of three pertinent medicinal plants i.e. Eurycoma harmandiana, Sophora flavescens and Andrographis paniculata. Phytocompounds
known to have antiviral properties were screened against the papain-like protease (PLpro) and main protease (Mpro) / 3-chymotrypsin-like Protease (3CLpro). Molecular docking with Canthin-6-One 9-O-Beta-Glucopyranoside showed the highest binding affinity and
least binding energy with both the proteases viz. PLpro and Mpro/ 3CLpro. ADMET analysis of the compound suggested that it is having drug-like properties like high gastrointestinal (gi-) absorption, no blood-brain barrier permeability, and high lipophilicity. |
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Are two consecutive negative RT-PCR results enough to rule out COVID-19? |
Waked, R, Makhoul, et al |
New Microbes and New Infections |
Clinical data| Données cliniques |
The coronavirus disease 2019 (COVID-19) pandemic is redefining the world we live in, and scientists are struggling
to find the best severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic tool. Routine testing is currently performed using real-time reverse transcription PCR (RT-PCR) of upper or lower respiratory tract secretions. We sought to demonstrate
the importance of conducting RT-PCR using deep sampling when initial upper respiratory testing is negative in cases of high index of suspicion for COVID-19. We present the case of a 47-year-old man admitted for fever and bilateral pneumonia diagnosed via chest
computed tomographic scan amidst the early peak of the COVID-19 pandemic, suggesting a SARS-CoV-2 infection. Two RT-PCR results from nasopharyngeal swab samples were negative. A bronchoscopy was then performed, and RT-PCR testing on bronchoalveolar lavage
samples yielded positive results, confirming the diagnosis of COVID-19 pneumonia. RT-PCR samples of the lower respiratory tract likely contain a higher virus load and thus retain a higher sensitivity for SARS-CoV-2 detection. © 2020 The Authors |
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Cancer patients in SARS-CoV-2 infection: A singlecenter experience from Wuhan |
Wang, J, Zhang, et al |
Journal of Cancer |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Cancer is a rare comorbidity of patients with COVID-19; however, it cannot be overemphasized due to its poorer outcomes.
Conducted a single-center cohort study to analyzed information of all inpatient cases with laboratory-confirmed COVID-19 who had treatment outcomes. A total of 716 patients with laboratory-confirmed COVID-19 infection were identified. Among them, a total of
12 cases (1.7%, 95% CI: 0.7%-2.6%) had history of cancer with 4 cases (33%) experiencing severe events. Compared with cases without cancer, patients with cancer have higher risks of severe events (33% vs 7.7%, p=0.012) and deaths (25% vs 3.6%, p=0.009). Found
that patients older than 60 years (75%), with other comorbidities (50%), or experiencing anticancer treatment in past month (42.9%) had a numerically higher incidence of severe events. |
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A nationwide survey of online teaching strategies in dental education in China |
Wang, K, Zhang, et al |
J Dent Educ |
Public Health response| Interventions de santé publique |
Surveyed the current online undergraduate education status in dental medicine in mainland China during the critical
stage of the COVID-19 outbreak. Ninety-seven percent of the respondents have opened online courses during COVID-19 pandemic in China, 74% of which chose live broadcast as the major teaching way. As compared with theoretical courses, fewer specialized practical
curriculums were set up online with a lower satisfaction from students in most dental schools. For the general evaluation of online learning from students of different dental schools, the "online learning content" received the highest support, while the "interaction
between teachers and students" showed the lowest satisfaction. |
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Wang, M, Zhao, et al |
Clin Infect Dis |
Therapeutics| Thérapeutique RCT |
To evaluate the efficacy and safety of leflunomide to treat COVID-19 patients with prolonged post-symptomatic viral
shedding. Conducted a prospective, randomized, controlled, open-label trial involving hospitalized adult COVID-19 patients with prolonged PCR positivity. Treatment with leflunomide was not associated with a difference from the interferon alone group in the
duration of viral shedding (hazard ratio for negative RT-PCR, 0.70; 95% confidence interval, 0.391-1.256; P=0.186). In addition, the patients given leflunomide did not have a substantially shorter length of hospital stay than patients treated with interferon
alone. |
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Effects of Cocooning on Coronavirus Disease Rates after Relaxing Social Distancing |
Wang, X, Du, et al |
Emerg Infect Dis |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
As coronavirus disease spreads throughout the United States, policymakers are contemplating reinstatement and relaxation
of shelter-in-place orders. By using a model capturing high-risk populations and transmission rates estimated from hospitalization data, we found that postponing relaxation will only delay future disease waves. Cocooning vulnerable populations can prevent
overwhelming medical surges. |
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Needs and Coping Behaviors of Youth in the U.S. During COVID-19 |
Waselewski, EA, Waselewski, et al |
Journal of Adolescent Health |
Public Health response| Interventions de santé publique |
Purpose: This study aimed to determine the needs, emotions, and coping behaviors of U.S. youth during COVID-19. Methods:
Two open-ended questions were posed to 1,174 MyVoice youth, aged 14–24 years, on March 20, 2020, regarding their needs and coping strategies during COVID-19. Qualitative responses were coded using thematic analysis and data were summarized with descriptive
statistics. Results: The average age of the 950 respondents (RR = 80.9%) was 18.9 ± 2.8 years with 52.1% female and 63.8% white. While 32.6% of participants felt resources were readily available, 35.2% felt resources were difficult to access or unavailable.
Participants also described both emotional responses (27.4%) and coping strategies (69.8%). Most emotional responses were negative, including symptoms of anxiety or depression. Commonly reported coping strategies included staying connected and maintaining
positivity. Conclusions: A significant portion of U.S. youth are experiencing unmet needs and negative emotions due to COVID-19 suggesting additional youth outreach is necessary to ensure basic needs, including socialization, are met. © 2020 Society for Adolescent
Health and Medicine |
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A Model for Undergraduate Medical Student Education in Otolaryngology During the
Post-COVID-19 Era |
Wickemeyer, JL, Yu, et al |
Otolaryngol Head Neck Surg |
Healthcare Response | Réponse des soins de santé |
The clinical learning environment is limited for undergraduate medical education in otolaryngology as the result of
coronavirus disease 2019. In an effort to foster and rebuild the attending-medical student relationship, we have developed the R4 teaching model. This model encourages the student to read background information, respond to questions, and review online with
faculty with the goal of realization of clinical decision making with gained knowledge. Within the R4 model, there are learning environment subtypes, including real patient cases, journal club, interactive quizzes, flipped classroom, and attending-lead discussions.
In the absence of a multitude of "live" patients, our curricula reinstate the core of clinical teaching for medical students. |
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Community
mental health survey in Covid-19 pandemic situation in Indonesia |
Widyana, R, Merli Safitri, et al |
Pakistan Journal of Medical and Health Sciences |
Public Health response| Interventions de santé publique |
The purpose of this study was to obtain an accurate picture of the level of anxiety, depression and stress during the
coronavirus outbreak (COVID-19). The results of the study showed that the number of respondents experiencing depression, anxiety, and stress in above normal (mild to severe) was 15.5%, 28.7%, and 22.2%., respectively. Thus, respondents more anxious rather
than stress and depression. Overall there are significant differences between the conditions of depression, anxiety, and stress based on differences in age of the subjects. |
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Wiemers, EE, Abrahams, et al |
Research in Social Stratification and Mobility |
Epidemiology| Épidémiologie |
The COVID-19 pandemic has magnified U.S. health disparities. Though disparities in COVID-19 hospitalization by race-ethnicity
are large, disparities by income and education have not been studied. Using an index based on preexisting health conditions and age, we estimate disparities in vulnerability to hospitalization from COVID-19 by income, education, and race-ethnicity for U.S.
adults. The index uses estimates of health condition and age effects on hospitalization for respiratory distress prior to the pandemic validated on COVID-19 hospitalizations. We find vulnerability arising from preexisting conditions is nearly three times higher
for bottom versus top income quartile adults and 60 % higher for those with a high-school degree relative to a college degree. Though non-Hispanic Blacks are more vulnerable than non-Hispanic Whites at comparable ages, among all adults the groups are equally
vulnerable because non-Hispanic Blacks are younger. Hispanics are the least vulnerable. Results suggest that income and education disparities in hospitalization are likely large and should be examined directly to further understand the unequal impact of the
pandemic. © 2020 Elsevier Ltd |
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Winearls, S, Swingwood, et al |
BMJ open respiratory research |
Clinical data| Données cliniques |
The global pandemic of COVID-19 has challenged the management of hypoxaemic respiratory failure and strained intensive
care unit resources. While prone positioning (PP) is an established therapy in mechanically ventilated patients with acute respiratory distress syndrome (ARDS), its role in conscious patients is less well defined. We retrospectively reviewed our experience
of implementing early PP in a cohort of 24 patients with acute hypoxaemic respiratory failure due to COVID-19 who required support with continuous positive airway pressure (CPAP). The use of PP alongside CPAP significantly increased both the ROX index and
arterial oxygen pressure:fractional inspired oxygen (PaO2:FiO2) ratio from baseline values (ROX index: 7.0±2.5 baseline vs 11.4±3.7 CPAP+PP, p<0.0001; PaO2:FiO2 ratio: 143±73 mm Hg baseline vs 252±87 mm Hg CPAP+PP, p<0.01), and the changes to both the ROX
index and PaO2:FiO2 ratio remained significant 1 hour after cessation of proning. The mean duration of PP in the first 24 hours was 8±5 hours. Few complications were observed and PP was continued for a mean of 10±5 days. From our experience in a dedicated
COVID-19 respiratory high care unit, PP alongside CPAP therapy was feasible, tolerated, safe and improved oxygenation. The use of conscious PP in ARDS warrants further investigation in randomised controlled trials. © Author(s) (or their employer(s)) 2020.
Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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Winkler, MS, Korsten, et al |
Ann Rheum Dis |
Clinical data| Données cliniques |
We describe here a case of immune reconstitution inflammatory syndrome (IRIS) treated with intravenous tocilizumab
and corticosteroids after initiation of antiretroviral therapy (ART) in COVID-19. After administration of tocilizumab and corticosteroids, fever, hyperleucocytosis and CD4+ T helper cells normalised, mechanical ventilation, vasopressor support and CRRT were
successfully discontinued. |
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Sociodemographic inequality in exposure to COVID-19-induced economic hardship in
the United Kingdom |
Witteveen, D |
Research in Social Stratification and Mobility |
Economics | Économie |
The COVID-19 pandemic led to a lockdown in European countries in the first half of 2020, including stay-at-home orders
and closure of non-essential businesses. To mitigate the detrimental effects on the financial stress of employees and households, the UK government implemented a furlough scheme that temporarily secured earnings up to 80 percent of regular pay. Other employees
were at risk of reduced work hours or permanent job loss. Using data from the UK Household Longitudinal Study COVID-19 Supplement, this study examines the extent to which different earnings groups and sociodemographic groups (gender, race/ethnicity, class
background) became exposed to economic hardship between March and May of 2020. Results indicate that lower earnings groups were more than twice as likely to experience economic hardship relative to top quintile earners. Furthermore, among pre-COVID employed
individuals, men and whites had a lower probability of being furloughed or dismissed from work. Analyses indicate that these are to a large extent attributable to gender earnings inequalities within occupations and the fact that women and racial-ethnic minorities
are employed in essential occupations. © 2020 Elsevier Ltd |
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Wu, CY, Yu, et al |
Journal of International Medical Research |
Clinical data| Données cliniques |
Case report of a positive COVID-19 patient with gastrointestinal symptoms as initial manifestations. A 42-year-old
woman presented to hospital who was suffering from epigastric discomfort and dyspepsia for the past 5 days. Before the onset of symptoms, she was healthy, and had no travel history to Wuhan or contact with laboratory-confirmed COVID-19 cases. Chest computed
tomography showed multiple ground-glass opacity in the lungs. Reverse transcription-polymerase chain reaction was negative for severe acute respiratory syndrome coronavirus-2. Polymerase chain reaction performed 2 days later was positive and she was diagnosed
with COVID-19. |
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Wu, J, Yu, et al |
International Journal of Infectious Diseases |
Clinical data| Données cliniques |
We report the case of a patient diagnosed with severe pneumonia due to coronavirus disease 2019 (COVID-19). A percutaneous
lung biopsy was performed under ultrasound guidance. Morphological and ultrastructural characteristics of the patient's lungs are presented, along with details of some important changes in inflammatory biological markers, in order to help better understand
the disease and provide clues to allow members of the multidisciplinary team to save more people. © 2020 |
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Wu, NicholasC, Yuan, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Epitopes that are conserved among SARS-like coronaviruses are attractive targets for design of cross-reactive vaccines
and therapeutics. CR3022 is a SARS-CoV neutralizing antibody to a highly conserved epitope on the receptor binding domain (RBD) on the spike protein that can cross-react with SARS-CoV-2, but with lower affinity. Using x-ray crystallography, mutagenesis, and
binding experiments, we illustrate that of four amino acid differences in the CR3022 epitope between SARS-CoV-2 and SARS-CoV, a single mutation P384A fully determines the affinity difference. CR3022 does not neutralize SARS-CoV-2, but the increased affinity
to SARS-CoV-2 P384A mutant now enables neutralization with a similar potency to SARS-CoV. We further investigated CR3022 interaction with the SARS-CoV spike protein by negative-stain EM and cryo-EM. Three CR3022 Fabs bind per trimer with the RBD observed in
different up-conformations due to considerable flexibility of the RBD. In one of these conformations, quaternary interactions are made by CR3022 to the N-terminal domain (NTD) of an adjacent subunit. Overall, this study provides insights into antigenic variation
and potential for cross-neutralizing epitopes on SARS-like viruses.Competing Interest StatementThe authors have declared no competing interest. |
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Wu, Q, Tang, et al |
Science of the Total Environment |
Public health interventions*| Interventions de santé publique |
The lockdown measures to restrict the spread of Coronavirus Disease 2019 (COVID-19) and the following unfavorable meteorology
in Beijing provided a natural experiment to examine how air mercury responds to strict control measures when the climate becomes humid and warm. Existing pollution control and additional lockdown measures reduced mercury emissions by 16.7 and 12.5 kg/d during
lockdown, respectively, which correspondingly reduced the concentrations of atmospheric mercury by 0.10 and 0.07 ng/m3. Emission reductions from cement clinker production contributed to the largest decrease in atmospheric mercury, implying potential mitigation
effects in this sector since it is currently the number one emitter in China. Changes in meteorology raised atmospheric mercury by 0.41 ng/m3. The increases in relative humidity (9.5%) and temperature (1.2 °C) significantly offset the effect of emission reduction
by 0.17 and 0.09 ng/m3, which highlights the challenge of air mercury control in humid and warm weather and the significance of understanding mercury behavior in the atmosphere and at atmospheric interfaces, especially the impact from relative humidity. |
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Xie, L, Luo, et al |
International Journal of Public Health |
Public Health response| Interventions de santé publique |
To investigate the immediate psychological effects of Coronavirus Disease 2019 (COVID-19) on medical and non-medical
students. A retrospective online survey of 805 medical students and 1900 non-medical students was conducted. Medical students estimated COVID-19 to be more serious and disastrous than non-medical students, while they scored lower than non-medical students
on the Impact of Event Scale-Revised (IES-R), and less severe anxiety and depression than non-medical students. The students experienced greater impact from the outbreak and a higher rate of anxiety and depression with increased time focusing on the outbreak.
The difference in psychological effects between medical and non-medical students was further enlarged when focusing time was prolonged. |
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Xie, Y, Wang, et al |
Zhonghua wei zhong bing ji jiu yi xue |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
To evaluate the clinical effect of integrated traditional Chinese and Western medicine on common type of COVID-19.
For a prospective single arm clinical study, patients with common type of COVID-19 admitted to seven designated hospitals for COVID-19 in Henan were enrolled and treated with integrated traditional Chinese and Western medicine. 86 cases were included in the
analysis, including 48 males (55.8%), aged 43.5 (35.0, 53.3) years old, 24 patients (27.9%) with previous medical history. Fifty-eight patients were primarily diagnosed COVID-19 and 28 patients were transferred. The 2019-nCoV nucleic acid of 86 cases (100%)
turned negative, and the median time of turning negative was 10 (7, 14) days. Eighty-six cases (100%) were discharged from hospital, and none turned into the severe type; the average length of hospital stay was (13.8±5.6) days. The scores of fever, cough,
chest tightness, shortness of breath, and fatigue decreased with the treatment time, and the scores of 7 days and 14 days after treatment were significantly lower than those before treatment fever. The improvement rate of X ray and CT image was 42.9% (12/28)
and 81.0% (64/79), respectively. |
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Xiong, H, Yi, et al |
Inquiry (United States) |
Healthcare Response | Réponse des soins de santé |
We performed a cross-sectional survey to investigate the psychological status and self-efficacy of nurses in public
hospital during COVID-19 outbreak between 16th and 25th February 2020. A total of 223 nurses participated in this study. The prevalence of anxiety and depression symptoms was 40.8% (CI 95%: 34.4%-47.2%) and 26.4% (CI 95%: 20.6%-42.2%), respectively. There
was no difference in the prevalence of anxiety symptoms among demographic variables. There was significant differences in the prevalence of depression symptoms according to professional titles (P =.020). The mean score of self-efficacy was 25.90 ± 7.55. The
self-efficacy was negatively correlated with anxiety (r = −0.161, P <.05). |
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Xu, S, Shao, et al |
Open Forum Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We retrospectively analyzed clinical characteristics of pregnant and nonpregnant women with COVID-19 aged from 20 to
40, Wuhan, and symptoms of pregnant women with COVID-19 and compared the clinical characteristics and symptoms to historic data previously reported for H1N1. Among 64 patients, 34 (53.13%) were pregnant, with higher proportion of exposure history (29.41% vs
6.67%) and more pulmonary infiltration on computed tomography test (50% vs 10%) compared to nonpregnant women. Of pregnant patients, 27 (79.41%) completed pregnancy, 5 (14.71%) had natural delivery, 18 (52.94%) had cesarean section, and 4 (11.76%) had abortion;
5 (14.71%) patients were asymptomatic. All 23 newborns had negative reverse-transcription polymerase chain results, and an average 1-minute Apgar score was 8-9 points. Pregnant and nonpregnant patients show differences in symptoms such as fever, expectoration,
and fatigue and on laboratory tests such as neurophils, fibrinogen, D-dimer, and erythrocyte sedimentation rate. Pregnant patients with COVID-19 tend to have more milder symptoms than those with H1N1. |
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ICT integration to support online learning during the COVID-19 outbreaks |
Yacob, A, Baharum, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Public Health response| Interventions de santé publique |
This paper aims to analyze the integration of ICT to support online learning during the covid-19 outbreaks. A questionnaire
on 114 respondents indicated that ICT integration has a great effectiveness for both teachers and the students during the Covid-19 outbreaks, with some improvements needed. |
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Yan, B, Wang, et al |
Computers, Materials and Continua |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We propose an improved method for predicting confirmed cases based on LSTM (Long-Short Term Memory) neural network.
This work compares the deviation between the experimental results of the improved LSTM prediction model and the digital prediction models (such as Logistic and Hill equations) with the real data as reference. This work uses the goodness of fitting to evaluate
the fitting effect of the improvement. Experiments show that the proposed approach has a smaller prediction deviation and a better fitting effect. Compared with the previous forecasting methods, the contributions of our proposed improvement methods are mainly
in the following aspects: 1) we have fully considered the spatiotemporal characteristics of the data, rather than single standardized data. 2) the improved parameter settings and evaluation indicators are more accurate for fitting and forecasting. 3) we consider
the impact of the epidemic stage and conduct reasonable data processing for different stage. |
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Yan, N, Xu, et al |
Frontiers in Neurology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To investigate the neurological symptoms and implications of patients with non-critically ill COVID-19 patients. This
retrospective cohort study investigated all COVID-19 patients admitted to Wuhan East-West Lake Fangcang shelter hospital. Among 1,682 patients with confirmed non-critically ill COVID-19, 509 patients (30.3%) had neurological symptoms, including myalgia (311,
18.5%), headache (216, 12.8%), fatigue (83, 4.9%), and dizziness (15, 0.9%). One hundred and fourteen patients (6.8%) were the expansion of pulmonary infection according to their chest CT images and medical history. Compared with patients without neurological
symptoms, patients with neurological symptoms had a significantly longer length of hospital stay, time of nucleic acid turning negative, and the mean time from onset of symptom to hospital admission (p < 0.05). Patients with neurological symptoms were more
likely to occur the expansion of pulmonary infection compared with the patients without neurological symptoms (46/509 9.0%] vs. 68/1,173 5.8%]). |
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Yang, A, Liu, et al |
Natural Product Communications |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In this study, we analyzed the mechanism of the Reyanning mixture and its effects against SARS-CoV-2 based on the method
of network pharmacology. We used the TCM Systems Pharmacology database and employed a similarity algorithm to screen and identify the bioactive ingredients and potential targets of the Reyanning mixture. The GeneCards database was used to predict and screen
the disease targets and build the active ingredient target network diagram. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to construct the target signal pathway associations. The STRING tool was used
to reconstruct the protein-protein interaction network. As a result, 27 candidate targets, such as tumor necrosis factor, interferon gamma, tumor protein P53, C-reactive protein, and peroxisome proliferator-activated receptor gamma, were identified among the
33 bioactive ingredients of the 4 TCMs in the Reyanning mixture with effects on treating SARS-CoV-2. These targets were significantly enriched in 20 KEGG pathways and associated with 48 diverse GO terms. All of these targets may play a role in inhibiting inflammatory
reactions, regulating immune function, and reducing lung injury to achieve the purpose of treating SARS-CoV-2. |
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Yang, R, Xiong, et al |
Eur J Clin Invest |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
In this retrospective study, epidemiological, clinical, laboratory, treatment and outcomes data of hospitalized patients
with severe COVID-19 in Zhongnan Hospital of Wuhan University, were collected. Binary logistic regression model was use to analyse risk factors for disease progression from severe COVID-19 illness to critical illness. The effectiveness and safety of the use
of methylprednisolone for patients with severe COVID-19 disease were evaluated. The results of the multivariate analysis from 175 patients with severe COVID-19 indicate that the use of methylprednisolone was a protective factor against disease progression
from severe to critical illness (P<0.001; OR: 0.054 95% CI: 0.017-0.173). Among patients with severe COVID-19 aged<65 years, both the proportion of patients who progressed to critical illness (42.2% vs 90.0%, P=0.000) and the mortality(6.7% vs 30.0%, P=0.002)
were lower for patients in methylprednisolone group, compared with those in the non-methylprednisolone group, whereas no statistical differences between the methylprednisolone group and the non-methylprednisolone group were found among COVID-19 patients older
than 65 years. Moreover, both the levels of CD4(+) T lymphocyte counts (646 vs 463/ul, P=0.007) and IL-6(241.9 vs 82.8pg/ml, P=0.025) were higher among patients with severe COVID-19 aged<65 years, compared with those patients ≥65 years old. |
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Transportation, germs, culture: a dynamic graph model of COVID-19
outbreak |
Yang, X, Xu, et al |
Quantitative Biology |
Modelling/ prediction| Modélisation/prédiction Transmission Public health interventions*|
Interventions de santé publique |
In this study, we designed a dynamic graph model, not for precisely predicting the number of infected cases, but for
a glance of the dynamics under a public epidemic emergency situation and of different contributing factors. We demonstrated the impact of asymptomatic transmission in this outbreak and showed the effectiveness of city lockdown to halt virus spread within a
city. We further illustrated that sudden emergence of a large number of cases could overwhelm the city medical system, and external medical aids are critical to not only containing the further spread of the virus but also reducing fatality. |
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Yasuda, H, Tsukune, et al |
Clinical Lymphoma, Myeloma and Leukemia |
Clinical data| Données cliniques |
We report the first case of persistent COVID-19 pneumonia that was still ongoing at 2 months after onset in a patient
with follicular lymphoma (FL) undergoing rituximab maintenance therapy. The patient failed to develop anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin (Ig)G and IgM antibodies, which was most probably the result of prior rituximab
therapy, and thus provoked this unusual chronic state of COVID-19 pneumonia. Patients undergoing recent rituximab therapy are likely to fail to develop anti-SARS-CoV-2 antibodies, which may lead to severe and prolonged COVID-19 infections. Rituximab therapy
should be avoided whenever possible during the COVID-19 pandemic. |
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Yau, K, Muller, et al |
American Journal of Kidney Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
We describe the course of the COVID-19 outbreak and the infection control measures taken for mitigation in a hemodialysis
centre in Toronto, Canada. This was a retrospective cohort study including 237 maintenance hemodialysis patients and 93 hemodialysis staff at a single hemodialysis center. Due to universal screening the primary outcome was detection of SARS-CoV-2 in nasopharyngeal
samples from patients and staff using reverse transcriptase–polymerase chain reaction (RT-PCR). 11 of 237 (4.6%) hemodialysis patients and 11 of 93 (12%) staff members had a positive RT-PCR test result for SARS-CoV-2. Among individuals testing positive, 12
of 22 (55%) were asymptomatic at time of testing and 7 of 22 (32%) were asymptomatic for the duration of follow-up. One patient was hospitalized at the time of SARS-CoV-2 infection and 4 additional patients with positive test results were subsequently hospitalized.
2 (18%) patients required admission to the intensive care unit. After 30 days’ follow-up, no patients had died or required mechanical ventilation. No hemodialysis staff required hospitalization. Universal droplet and contact precautions were implemented during
the outbreak. Hemodialysis staff with SARS-CoV-2 infection were placed on home quarantine regardless of symptom status. Patients with SARS-CoV-2 infection, including asymptomatic individuals, were treated with droplet and contact precautions until confirmation
of negative SARS-CoV-2 RT-PCR test results. Analysis of the outbreak identified 2 index cases with subsequent nosocomial transmission within the dialysis unit and in shared shuttle buses to the hemodialysis unit. |
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32911874; Infection of Brain Organoids and 2D Cortical Neurons with SARS-CoV-2 Pseudovirus |
Yi, SA, Nam, et al |
Viruses |
Coronavirology| Coronavirologie |
we utilized human embryonic stem cell-derived brain organoids and monolayer cortical neurons to investigate infection
of brain with pseudotyped SARS-CoV-2 viral particles. Spike-containing SARS-CoV-2 pseudovirus infected neural layers within brain organoids. The expression of ACE2, a host cell receptor for SARS-CoV-2, was sustained during the development of brain organoids,
especially in the somas of mature neurons, while remaining rare in neural stem cells. However, pseudotyped SARS-CoV-2 was observed in the axon of neurons, which lack ACE2. Neural infectivity of SARS-CoV-2 pseudovirus did not increase in proportion to viral
load, but only 10% of neurons were infected. |
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Spread of coronavirus 2019 from Wuhan to rural villages in the Hubei Province |
You, M, Wu, et al |
Open Forum Infectious Diseases |
Transmission Public health interventions*| Interventions de santé publique |
This study aimed to describe the spread of coronavirus disease 2019 (COVID-19) from Wuhan to rural villages in the
Hubei Province. COVID-19 spread from Wuhan to other cities and rural areas in Hubei, but the disease did not become widespread in rural villages because of strict prevention measures and urbanization. According to the fluctuation in the number of confirmed
cases reported in Hubei after January 23, 2020, we inferred that the infected patients on the same day will become ill during the next 20 days. The advanced traffic system facilitates the direct spread of COVID-19 from Wuhan to counties, towns, and villages
in the Hubei Province.There is a low possibility of COVID-19 spread from prefecture-level cities to rural areas. The findings imply that the government should limit the travelers from the cities to the rural areas, pay more attention to the prevention and
control of severe acute respiratory syndrome coronavirus 2 in cities, and appropriately prolong the isolated observation period of travelers. |
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Rapid Recovery from Critical COVID-19 Respiratory Failure after
treatment with VIP |
Youssef, JG |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
Background: Vasoactive Intestinal Peptide (VIP) blocks replication of the SARS-CoV-2 virus, inhibits cytokine synthesis,
prevents cytopathy, and upregulates surfactant production in human pulmonary cells. RLF-100™ (aviptadil), is currently in phase 2/3 trials with FDA Fast Track designation for treating Critical COVID-19 with Respiratory Failure. Methods: Case series of 21 consecutive
with Critical COVID-19 and multiple co-morbidities, treated with intravenous aviptadil (synthetic VIP). Sixteen patients were treated with ventilation alone and five with extracorporeal membrane oxygenation (ECMO). Results: So far, 19 of 21 patients have survived.
Improved radiographic appearance was seen in both lungs of 17 patients and in one lung of 2 patients. A mean 2.5-fold increase in PaO2:FiO2 ratio was seen (P<0.0001) with complete remission from respiratory failure in 9 patients and ongoing improvement in
10. Seven patients were discharged from the hospital, 7 sent to intermediate care, and 5 remain in the ICU. Four of 5 patients on ECMO have been decannulated, and thus far three have been discharged. A 75% (95% CI±3%: P<.001) reduction in IL-6 was seen with
corresponding decrease in C-reactive protein. A median 3 point reduction (mean 2.7; P<0.001) in the WHO Ordinal Scale was observed (P<.001). Comment: The short term outcome in these 21 patients represent a dramatic response in patients whose comorbidities
precluded their randomization in all other trials of COVID therapeutics and who were previously treated with remdesivir, tocilizumab, or convalescent plasma. Improvement in radiographic appearance, oxygenation requirement, and inflammatory markers is consistent
with in vitro evidence of direct anti-viral effect |
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Resumption of Endodontic Practices in COVID-19 Hardest-Hit Area of China: A Web-based
Survey |
Yu, J, Hua, et al |
Journal of endodontics |
Healthcare Response | Réponse des soins de santé |
The purpose of this study was to investigate the resumption of endodontic practices in Hubei Province, China 1 month
after the end of the lockdown. A total of 322 participants completed the survey. Most respondents (62%) were from Wuhan. Almost 83% of the respondents have resumed their endodontic practice partially or fully. Most respondents in practice (99%) would take
measures to screen patients before treatment including paid screening measures. More than 93% of the respondents reported having taken special measures for routine endodontic treatment at this stage, with the most common measure taken being wearing an N95
mask. The rubber dam was recognized as efficient in preventing infection by most respondents. Many respondents were concerned about contracting coronavirus disease 2019 (COVID-19) as a result of routine endodontic practice at this stage, and respondents with
more than 11 years of endodontic experience were significantly less concerned about infection compared with those with fewer than 5 years of experience (P <.05). |
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Yuan, S, Chu, et al |
Science advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The authors identified N-(p-amylcinnamoyl)anthranilic acid (ACA), a chemical that can interrupt AP2M1-virus interaction
and exhibit potent antiviral efficacy against a number of viruses in vitro and in vivo, such as influenza A, Zika, coronaviruses including MERS-CoV and SARS-CoV-2 etc. The study comprehensively evaluated the antiviral potency of drug ACA in vivo and in vitro
and established an integrative platform named CWID to identify the host interaction AP2M1/YxxØ and it's biological importance in the viral replication cycle. The study demonstrated an evolutionary correlation mechanism between the virus and host protein-protein
interaction. The use of CWID platform facilitated the unbiased identification of drug binding target. The study also demonstrated that AP2M1/YxxØ interaction is a drug about target for a broad-spectrum antibiotic therapy |
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Zawawi, Zarina Mohd, Suppiah, et al |
Research Square prepub |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
Here, we report the whole genome sequencing analysis of SARS-CoV-2 strains in Malaysia isolated from six patients diagnosed
with COVID-19. Six full genome sequences of SARS-CoV-2 comprising of strains from 1st wave (25th January 2020) and 2nd wave (27th February 2020) infection were obtained. Downstream analysis demonstrated diversity among the Malaysian strains with several synonymous
and non-synonymous mutations in four of the six cases, affecting the genes M, orf1ab, and S of the SARS-CoV-2 virus. The phylogenetic analysis revealed viral genome sequences of Malaysian SARS-CoV-2 strains clustered under the ancestral Type B. |
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Zebin, T, Rezvy, et al |
Applied Intelligence |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Chest X-rays are playing an important role in the testing and diagnosis of COVID-19 disease in the recent pandemic.
However, due to the limited amount of labelled medical images, automated classification of these images for positive and negative cases remains the biggest challenge in their reliable use in diagnosis and disease progression. We implemented a transfer learning
pipeline for classifying COVID-19 chest X-ray images from two publicly available chest X-ray datasets1,2. The classifier effectively distinguishes inflammation in lungs due to COVID-19 and Pneumonia from the ones with no infection (normal). We have used multiple
pre-trained convolutional backbones as the feature extractor and achieved an overall detection accuracy of 90%, 94.3%, and 96.8% for the VGG16, ResNet50, and EfficientNetB0 backbones respectively. Additionally, we trained a generative adversarial framework
(a CycleGAN) to generate and augment the minority COVID-19 class in our approach. For visual explanations and interpretation purposes, we implemented a gradient class activation mapping technique to highlight the regions of the input image that are important
for predictions. Additionally, these visualizations can be used to monitor the affected lung regions during disease progression and severity stages. © 2020, The Author(s). |
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Zeenny, RM, Ramia, et al |
J Pharm Policy Pract |
Healthcare Response | Réponse des soins de santé |
The primary objective of this survey is to assess the knowledge, attitude, and practice of hospital pharmacists in
Lebanon towards COVID-19 pandemic and explore the level of health emergency preparedness of Lebanese hospitals in response to this outbreak. A total of 81 questionnaires were completed; the participants were able to know > 90% of the knowledge-based questions
regarding COVID-19. Most of the respondents were concerned about getting infected and their families due to their professional exposure. Similarly, around 67% were following the safety recommendations. Most of the participants agreed that they are facing shortages,
rising prices, and delays in supply of masks and sanitizers. In terms of COVID-19 readiness, about 50% of hospitals have taken practical steps. |
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Mesenchymal stem cell treatment in a critically ill COVID-19 patient: a case report |
Zengin, R, Beyaz, et al |
Stem Cell Investigation |
Clinical data| Données cliniques |
An outbreak of a new coronavirus causing severe respiratory disease (COVID-19) was first reported in China and rapidly
spread worldwide. Clinical spectrum changes from asymptomatic infection to severe illness and even death, and no specific treatment is currently available. A range of antiviral, antimalarial and antibiotic agents are being used. We report a case of a COVID-19
patient that progressed to severe disease requiring intubation and intensive care. We performed mesenchymal stem cell (MSC) transplantation considering the signs showing persistent excessive immune response and deterioration despite all supportive and drug
therapies. The two rounds of transplantation did not result in any severe complications and was well-tolerated. Clinical signs were improved. The use of MSC therapy may be considered for compassionate use in selected patients. © Stem Cell Investigation. All
rights reserved. |
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Zhang, Q, Pan, et al |
Science of the Total Environment |
Public health interventions*| Interventions de santé publique |
A top-down approach was employed to estimate the influence of lockdown measures implemented during the COVID-19 pandemic
on NOx emissions and subsequent influence on surface PM2.5 and ozone in China. The nation-wide NOx emission reduction of 53.4% due to the lockdown in 2020 quarter one in China may represent the current upper limit of China's NOx emission control. During the
Chinese New Year Holiday (P2), NOx emission intensity in China declined by 44.7% compared to the preceding 3 weeks (P1). NOx emission intensity increased by 20.3% during the 4 weeks after P2 (P3), despite the unchanged NO2 column. It recovered to 2019 level
at the end of March (P4). The East China (22°N - 42°N, 102°E - 122°E) received greater influence from COVID-19. Overall NOx emission from East China for 2020 first quarter is 40.5% lower than 2019, and in P4 it is still 22.9% below the same period in 2019.
The 40.5% decrease of NOx emission in 2020 first quarter in East China lead to 36.5% increase of surface O3 and 12.5% decrease of surface PM2.5. The elevated O3 promotes the secondary aerosol formation through heterogeneous pathways. We recommend that the
complicated interaction between PM2.5 and O3 should be considered in the emission control strategy making process in the future. © 2020 Elsevier B.V. |
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Zhang, Q, Schultz, et al |
Mov Disord |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A wide range of case fatality rate has been reported in patients with parkinson's disease. The significance of parkinson
disease (PD) as a risk factor has not been well described in context of COVID-19. COVID-19 patients with PD and non-PD demonstrated different age, sex and race distribution. A conditional logistic regression found that PD patients had a significant higher
risk of dying from covid-19 compared to patients without PD. The dataset lacks information on key comorbidities as well as does not include information on recovery, what does indicate the importance of preventing transmission in PD patients. |
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Zhang, R, Guo, et al |
Interdiscip Sci |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a major pandemic outbreak
recently. Various diagnostic technologies have been under active development. The novel coronavirus disease (COVID-19) may induce pulmonary failures, and chest X-ray imaging becomes one of the major confirmed diagnostic technologies. The very limited number
of publicly available samples has rendered the training of the deep neural networks unstable and inaccurate. This study proposed a two-step transfer learning pipeline and a deep residual network framework COVID19XrayNet for the COVID-19 detection problem based
on chest X-ray images. COVID19XrayNet firstly tunes the transferred model on a large dataset of chest X-ray images, which is further tuned using a small dataset of annotated chest X-ray images. The final model achieved 0.9108 accuracy. The experimental data
also suggested that the model may be improved with more training samples being released. COVID19XrayNet, a two-step transfer learning framework designed for biomedical images. |
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Zhang, S, Xu, et al |
Sleep medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Purpose: To explore the relationship between symptomless multi-Variable apnea prediction (sMVAP) index and adverse
outcomes of patients with Corona Virus Disease 2019 (COVID-19). Methods: According to the sMVAP quartiles, we divided all patients into four groups. The clinical electronic medical records, nursing records, laboratory findings, and radiological examinations
for all patients with laboratory confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection were reviewed. Cox proportional hazard ratio (HR) models were used to determine the risk factors associated with in hospital death. Results: A
total of 97 patients were included in this study. The “Quartile 4” group 's ICU transfer rate was significantly higher than the “Quartile 1” group. Coronary heart disease, high d-dimer and sMVAP at admission were associated with increased odds of death. Conclusions:
Using the sMVAP index for obstructive sleep apnea hypopnea syndrome (OSAHS) risk assessment, and then predicting the adverse outcomes of COVID-19 patients, is an effective method. Therefore, the use of sMVAP index for OSAHS screening for inpatients with COVID-19
should be vigorously promoted, and high-risk patients should be effectively managed. © 2020 Elsevier B.V. |
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Zhang, S, Xu, et al |
Sleep medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Purpose: To determine the relationship between the improved night shift schedule and the mortality of critically ill
patients with Corona Virus Disease 2019 (COVID-19). Methods: According to the time of the implementation of the new night shift schedule, we divided all patients into two groups: initial period group and recent period group. The clinical electronic medical
records, nursing records, laboratory findings, and radiological examinations for all patients with laboratory confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection were reviewed. Cox proportional hazard ratio (HR) models were used
to determine the risk factors associated with in hospital death. Results: A total of 75 patients were included in this study. Initial period group includes 45 patients and recent period group includes 30 patients. The difference in mortality between the two
groups was significant, 77.8% and 36.7%, respectively. Leukocytosis at admission and admitted to hospital before the new night shift schedule were associated with increased odds of death. Conclusions: Shift arrangement of medical staff are associated with
the mortality of critically ill patients with COVID-19. The new night shift schedule might improve the continuity of treatment, thereby improving the overall quality of medical work and reducing the mortality of critically ill patients. © 2020 Elsevier B.V. |
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Research on mobile impulse purchase intention in the perspective of system users
during COVID-19 |
Zhang, W, Leng, et al |
Personal and Ubiquitous Computing |
Public Health response| Interventions de santé publique |
This article aims to explore the generation process of consumers’ impulsive purchase intention during the COVID-19
outbreak from the perspective of system users. For this purpose, the research proposes three mobile situation factors: personalized recommendation, visual appeal, and system usability. They have a positive impact on impulse purchase intention by influencing
perceived arousal and perceived enjoyment. The experimental method is used for data collection and hypothesis testing. All the hypotheses are supported. And the theoretical value of the model of “mobile environment stimulation-consumer emotion-impulse purchase
intention” is confirmed. Based on the conclusion, management suggestions are proposed for mobile shopping merchants from the perspective of improving consumers’ shopping experience and expanding marketing. |
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Covid-19 public opinion and emotion monitoring system based on time series thermal
new word mining |
Zhang, Y, Cheng, et al |
Computers, Materials and Continua |
Public Health response| Interventions de santé publique |
The authors developed a model that employs word mining to study trends in public emotions in response to the COVID-19
pandemic. The system can judge the positive and negative emotions of the reviewer based on the comments, and can also reflect the depth of the seven emotions such as Hopeful, Happy, and Depressed. We designed a large data visualization screen, which can clearly
show the trend of public emotions, the proportion of various emotion categories, keywords, hot topics, etc., and fully and intuitively reflect the development of public opinion. |
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Zhang, Y, Cheng, et al |
Chinese Journal of Perinatal Medicine |
Clinical data| Données cliniques |
We present a case of severe COVID-19 in a male newborn. A 22-day infant was transferred to Children's Hospital Affiliated
to Zhengzhou University due to "intermittent fever for 18 days". After admission, the infant presented with cough, occasional choke, shortness of breath despite nasal catheter oxygen inhalation, increased heart rate, low urine volume, and an enlarged liver
2 cm below the right costal margin. The baby was diagnosed with severe COVID-19 accompanied by anemia, hyperkalemia, pneumonia, and atrial septal defect seen on the echocardiogram. After isolation in an incubator, oxygen inhalation, cardiotonic intervention,
blood transfusion and antiviral treatment, the patient made a good recovery, with good breastfeeding, significant resorption of the lung inflammation and no fever or respiratory symptoms. The baby was discharged 14 days after hospitalization, with negative
results for nucleic acid test of pharyngeal swab for 2 consecutive times. |
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Zhao, K, Huang, et al |
Open Forum Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Background. Various types of pulmonary diseases are associated with iron deficiency. However, information on iron status
in coronavirus disease 2019 (COVID-19) is scarce. Methods. This study included 50 hospitalized patients with confirmed COVID-19. The role of serum iron in predicting severity and mortality of COVID-19 was evaluated. Results. The most common symptoms of COVID-19
patients in this study were cough (82%), fever (64%), and chest distress (42%). Of the 50 patients, 45 (90%) patients had abnormally low serum iron levels (<7.8 μmol/L). The severity of COVID-19 was negatively correlated with serum iron levels before and after
treatment and was positively correlated with C-reactive protein, serum amyloid A, D-dimer, lactate dehydrogenase, urea nitrogen, and myoglobin levels. Decreased serum iron level could predict the transition of COVID-19 from mild to severe and critical illness.
Seven (53.8%) patients with a lower serum iron level after treatment in the critical group had died. There was a significant difference in posttreatment serum iron levels between COVID-19 survivors and nonsurvivors. Conclusions. Serum iron deficiency was detected
in the patients with COVID-19. The severity and mortality of the disease was closely correlated with serum iron levels. Low serum iron concentration was an independent risk factor for death in COVID-19 patients. © The Author(s) 2020. |
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Zhao, SZ, Wong, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
We analyzed compliance with social distancing and its associations with mental health. Of the 1501 respondents (52.5%
female, 72.3% aged 18–59 years), 74.2%, 72.7%, and 59.7% reported avoiding going out, going to crowded places, and attending social gatherings of more than four people, respectively. Most respondents had stayed-at-home for at least four of the past seven days
(58.4%; mean 4.12, Standard Deviation 2.05). Adoption, perceived effectiveness, and perceived compliance with social distancing were associated with lower stress levels and less anxiety and depressive symptoms (all p < 0.01). However, more days stayed-at-home
were associated with more depressive symptoms (aOR 1.09; 95% CI 1.00, 1.18). The long-term psychological impact in relation to social distancing and staying-at-home requires further investigation. |
|
|
Zheng, L, Miao, et al |
Appl Psychol Health Well Being |
Public Health response| Interventions de santé publique |
This study aimed to examine the effects of COVID-19 on life satisfaction and perceived general health and reveal the
buffering effect of perceived control on coping with COVID-19. We collected 1,847 participants' data from 31 pandemic-affected provinces in China and obtained regional epidemic data of the same provinces. We employed a moderated mediation model with both individuals'
self-report data and regional epidemic data to verify the hypotheses. Our findings indicate that perceived control may act as a protective factor buffering the psychological impact of the pandemic on general health and life satisfaction. Psychological distance
can serve as a mediator that explains how the COVID-19 pandemic impacts perceived general health and life satisfaction. |
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|
Zhi-Xing, F, Yang, et al |
Cardiovascular Diagnosis and Therapy |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
In this retrospective study, we compared the clinical characteristics of COVID-19 patients with different troponin
I (TnI) levels during hospitalization to provide a clinical reference for the identification of those at high-risk for cardiac injury. Eighty-nine patients were diagnosed with COVID-19 and underwent TnI testing during hospitalization in Yichang Central People’s
Hospital and Yichang Third People’s Hospital between January 23 and February 19, 2020. The incidence of elevated TnI in our patient cohort was 24.7%. A history of coronary heart disease, advanced age, decreased lymphocyte count, increased IL-6, increased myoglobin,
and prolonged APTT were independent influencing factors of elevated TnI in COVID-19 patients. COVID-19 patients with these characteristics are prone to myocardial injury. |
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Zhou, Z, Zhou, et al |
Cell Discovery |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Previous studies have found that the absorption of MIR2911 in honeysuckle decoction (HD) inhibits SARS-CoV-2 replication
and accelerates the negative conversion of infected patients. The SID1 transmembrane family member 1 (SIDT1) in the gastric pit cell membrane mediates the delivery of MIR2911 in HD to target cells. This study sequenced the SIDT1 gene in 135 healthy volunteers
and revealed the presence of a polymorphism (rs2271496) in 16% of subjects. The results of in vitro analyses preformed by this group suggest that the amino acid replacement caused by the polymorphism compromises the capability for exogenous MIR2911 absorption
in vivo, which ultimately leads to the reduction of the level of MIR2911 in blood. Subsequently, cells expressing SARS-CoV-2 or S-protein were exposed to circulating exosomes from WT and polymorphic subjects before and after consumption of HD. The results
of these analyses suggested that decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism leads to a failure to inhibit SARS-CoV-2 replication. |
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32909725; Hypernatremia-A Manifestation of COVID-19: A Case Series |
Zimmer, MA, Zink, et al |
A&A practice |
Clinical data| Données cliniques |
We report for the first time therapy-resistant hypernatremia (plasma sodium concentration ≥150 mmol per liter) developing
in 6 of 12 critically ill coronavirus disease 2019 (COVID-19) patients age 57-84 years requiring mechanical ventilation. There was no correlation between plasma sodium concentrations and sodium input. Plasma concentrations of chloride were elevated, those
of potassium decreased. These findings are consistent with abnormally increased renal sodium reabsorption, possibly caused by increased angiotensin II activity secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced downregulation
of angiotensin-converting enzyme 2 (ACE2) receptors. As hypernatremia was associated with increased length of intensive care unit stay, special attention should be paid to the electrolyte status of COVID-19 patients. |
|
Zongo, P, Zorom, et al |
Epidemiol Infect |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
This paper used mathematical modelling to assess whether the containment measures imposed by most of the world governments
are effective and sufficient to stop the epidemic of COVID-19 beyond the lock-down period. Using French data, the results of this modelling suggest that the containment methods have slowed the growth of the outbreak but are only effective with long term compliance
of a very large fraction of the population. Easing of social distancing restrictions was predicted to be effective to overcome the outbreak only if transmission rates are decreased to 75% and testing volume is multiplied by three. |
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Cod19 and cod20: An Italian experience of active home surveillance in covid-19 patients |
Zuccotti, GV, Bertoli, et al |
International Journal of Environmental Research and Public Health |
Public health interventions*| Interventions de santé publique Public Health response|
Interventions de santé publique |
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic found Italy unprepared to cope with the large
concentrated numbers of patients infected with coronavirus disease 2019 (COVID-19) who often required hospital admission and in many cases intensive care. This pandemic very quickly overwhelmed the Italian Healthcare System. This paper describes the Active
Home Surveillance System (Operations Center for Discharged Patients; COD19) and the Home Hospital Care System (COD20) and presents the clinical data collected and the level of user satisfaction with the service. The Operations Center for Discharged Patients
(COD19) is an active surveillance service for home-care patients which involves: (1) monitoring critical clinical conditions; (2) recognizing social and health issues; (3) and providing necessary clinical services in the form of a telemedicine service. COD20
is a patient-specialist video consultation service that allows to perform an assessment of clinical conditions and any need to visit; defining the priority of access to specialist outpatient visits in the presence or manageable with the new video consultation
model. This service was immediately necessary during the COD19 monitoring. COD19 and COD20 are based on the Amazon Web Services Serverless certified platform. The COD19 and COD20 platform can be intrinsically utilized for future epidemic outbreaks; also those
with non-respiratory transmission; and is sufficiently flexible to adapt to natural catastrophes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
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Epidemic mitigation by statistical inference from contact tracing data |
|
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This study developed Bayesian inference methods to estimate the risk that an individual is infected. This inference
is based on the list of his recent contacts and their own risk levels, as well as personal information such as results of tests or presence of syndromes. Proposed to use probabilistic risk estimation in order to optimize testing and quarantining strategies
for the control of an epidemic. Results show that in some range of epidemic spreading (typically when the manual tracing of all contacts of infected people becomes practically impossible, but before the fraction of infected people reaches the scale where a
lock-down becomes unavoidable), this inference of individuals at risk could be an efficient way to mitigate the epidemic. These approaches translate into fully distributed algorithms that only require communication between individuals who have recently been
in contact. Such communication may be encrypted and anonymized and thus compatible with privacy preserving standards. |
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Assessment of Countries' Preparedness and Lockdown Effectiveness in Confronting COVID-19 |
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Disaster Medicine and Public Health Preparedness |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study assessed the risks in confronting the COVID-19 pandemic and the ongoing lockdown effectiveness in Italy,
Germany, Spain, France, and the USA using China's lockdown model simulation, and cases forecast until the plateau phase. Total Risk Assessment (TRA) evaluation tool was used to assess the pre-pandemic stage risks, pandemic threshold fast responsiveness, and
the ongoing performance until plateau. The Infected Patient Ratio (IPR) tool was developed to measure the number of patients resulting from 1 infector during the incubation period. Both IPR and TRA were used together to forecast inflection points, plateau
phases, intensive care units’ and ventilators’ breakpoints, and the Total Fatality Ratio.In Italy, Spain, France, Germany, and the USA, an inflection point is predicted within the first 15 days of April, to arrive at a plateau after another 30 to 80 days.
Variations in IPR drop are expected due to variations in lockdown timing, the extent of adherence to it, and the number of tests performed by each country. |
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Male predisposition to severe COVID-19: Review of evidence and potential therapeutic
prospects |
Acheampong, DO, Barffour, et al |
Biomedicine and Pharmacotherapy |
Review Literature| Revue de littérature |
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Data-driven modeling for different stages of pandemic response |
Adiga, Aniruddha, Chen, et al |
arXiv |
Review Literature| Revue de littérature |
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Adiga, Aniruddha, Dubhaski, et al |
arXiv |
Review Literature| Revue de littérature |
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Aleksova, A, Ferro, et al |
J Intern Med |
Review Literature| Revue de littérature |
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AlShoaibi, NA, Maghrabi, et al |
Ann Saudi Med |
Review Literature| Revue de littérature |
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Aquino-Canchari, C, Quispe-Arrieta, et al |
Revista Habanera de Ciencias Medicas |
Review Literature| Revue de littérature |
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The Financial Impacts of the COVID-19 Crisis on the Practices of Cosmetic/Aesthetic
Plastic Surgeons |
Arnautovic, A, Hamidian Jahromi, et al |
Aesthetic Plastic Surgery |
Review Literature| Revue de littérature |
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Arora, A, Jha, et al |
Asian Journal of Psychiatry |
Review Literature| Revue de littérature |
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Pediatric ophthalmology in the era of COVID-19: Management of emergent non-emergent
patients |
Atalay, HT |
Retina-Vitreus |
Review Literature| Revue de littérature |
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Azari, AA, Arabi, et al |
Journal of Ophthalmic and Vision Research |
Review Literature| Revue de littérature |
SR: scientific literature published as of February 2020 was thoroughly reviewed by searching PubMed, the ISI web of
knowledge database, and the Cochrane library using relevant keywords. |
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Factors influencing people’s participation in home garden project during
covid-19 pandemic: A review |
Aziz, SRA, Zain, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Review Literature| Revue de littérature |
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32920565; Natural selection versus creation: a review on the origin of SARS-COV-2 |
Barh, D, Silva Andrade, et al |
Le infezioni in medicina |
Review Literature| Revue de littérature |
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Bastaminejad, S, Bakhtiyari, et al |
Curr Mol Med |
Review Literature| Revue de littérature |
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Bhattacharjee, S, Bahl, et al |
BMJ open respiratory research |
Review Literature| Revue de littérature |
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32913357; Competing with a pandemic: Trends in research design in a time of Covid-19 |
Bian, SX, Lin, et al |
PloS one |
Review Literature| Revue de littérature |
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Feminine? Masculine? Androgynous leadership as a necessity in COVID-19 |
Blake-Beard, S, Shapiro, et al |
Gender in Management |
Review Literature| Revue de littérature |
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Transformation or evolution?: Education 4.0, teaching and learning in the digital
age |
Bonfield, CA, Salter, et al |
Higher Education Pedagogies |
Review Literature| Revue de littérature |
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The Australian Labour Market and the Early Impact of COVID-19: An Assessment |
Borland, J, Charlton, et al |
Australian Economic Review |
Review Literature| Revue de littérature |
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Brave, H, Macloughlin, et al |
International Journal of Molecular Sciences |
Review Literature| Revue de littérature |
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Calderón-Garcidueñas, L, Torres-Jardón, et al |
J Alzheimers Dis |
Review Literature| Revue de littérature |
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32911691; Dendritic Cells and SARS-CoV-2 Infection: Still an Unclarified Connection |
Campana, P, Parisi, et al |
Cells |
Review Literature| Revue de littérature |
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Maternal and neonatal outcomes in pregnant women with COVID-19: a systemic
review |
Cao, Y, Chen, et al |
Chinese Journal of Perinatal Medicine |
Review Literature| Revue de littérature |
SR: PubMed, Embase, China National Knowledge Infrastructure, China Academic Journals, and Wanfang Databases were searched
to retrieve articles on COVID-19 in pregnancy published from December 1, 2019, to April 9, 2020. Pregnant women are less likely to progress to severe COVID-19 and mostly have a good outcome. Despite reports of adverse neonatal outcomes, evidence of intrauterine
vertical transmission of 2019-nCoV remains insufficient. |
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Cascón-Katchadourian, JD |
Profesional de la Informacion |
Review Literature| Revue de littérature |
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32921717; COVID-19 and literature evidence: should we publish anything and everything? |
Chan, J, Oo, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
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Cherkaoui, S, Boukherouk, et al |
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Review Literature| Revue de littérature |
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Chow, KM, Law, et al |
International Journal of Environmental Research and Public Health |
Review Literature| Revue de littérature |
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Cook, J, Pressler, et al |
Clin Transl Sci |
Review Literature| Revue de littérature |
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Daluwathumullagamage, DJ, Sims, et al |
International Journal of Financial Studies |
Review Literature| Revue de littérature |
SR:
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COVID-19
pandemic - a narrative review of the potential roles of chloroquine and hydroxychloroquine |
de Barros, CM, de Faria Almeida, et al |
Pain Physician |
Review Literature| Revue de littérature |
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de la Caridad Ribot Reyes, V, Paredes, et al |
Revista Habanera de Ciencias Medicas |
Review Literature| Revue de littérature |
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De Sanctis, V, Canatan, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
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32919592; Editorial overview: Combating measles during a COVID-19 pandemic |
de Swart, RL, Takeda, et al |
Current opinion in virology |
Review Literature| Revue de littérature |
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Dehaghi, BF, Ghodrati-Torbati, et al |
Investigacion y Educacion en Enfermeria |
Review Literature| Revue de littérature |
SR: literature search was performed using different databases until April 30, 2020.
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Overview of novel coronavirus disease 2019 (COVID 19) and food safety |
Demirhan, BE, Demirhan, et al |
Gazi Medical Journal |
Review Literature| Revue de littérature |
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Dherange, P, Lang, et al |
JACC: Clinical Electrophysiology |
Review Literature| Revue de littérature |
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Drenovska, K, Schmidt, et al |
Int J Dermatol |
Review Literature| Revue de littérature |
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D'Souza, R, Ashraf, et al |
Ultrasound Obstet Gynecol |
Review Literature| Revue de littérature |
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Picking up a Fight: Fine Tuning Mitochondrial Innate Immune Defenses Against RNA
Viruses |
Dutta, S, Das, et al |
Frontiers in Microbiology |
Review Literature| Revue de littérature |
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Benzothiazole moieties and their derivatives as antimicrobial and antiviral agents:
A mini-review |
Elamin, MB, Elaziz, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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An overview and update of COVID-19: Can SARS-coronavirus-2 infect farm
animals? |
El-Sabrout, K, Soliman, et al |
Journal of Animal Health and Production |
Review Literature| Revue de littérature |
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Eslami, P, Tabary, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
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Esposito, S, Gnocchi, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
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Druggable targets of SARS-CoV-2 and treatment opportunities for COVID-19 |
Faheem, Kumar, BK, et al |
Bioorganic chemistry |
Review Literature| Revue de littérature |
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32921729; Sars-CoV-2 infection in patients with cystic fibrosis. An overwiew |
Fainardi, V, Longo, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
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Ferreira-Oliveira, A, Rodrigues, et al |
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Review Literature| Revue de littérature |
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Fiolet, T, Guihur, et al |
Clinical Microbiology and Infection |
Review Literature| Revue de littérature |
SR-MA: PubMed, Web of Science, Embase Cochrane Library, Google Scholar and MedRxiv were searched up to 25 July 2020.
Hydroxychloroquine alone was not associated with reduced mortality in hospitalized COVID-19 patients but the combination of hydroxychloroquine and azithromycin significantly increased mortality.
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Fouché, A, Fouché, et al |
Child Abuse and Neglect |
Review Literature| Revue de littérature |
Rapid Review: searched two databases (SA Government platform and LexisNexus) for legislation, directives and regulations
pertaining to South Africa's strict lockdown (15 March to 31 May 2020). C-19 legislation has potential to advance children's protection from abuse and neglect during emergency times. However, this potential will be curtailed if C-19 legislation is inadequately
operationalised and/or prioritises physical health to the detriment of children's intellectual, emotional, social and security needs. |
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Gadi, N, Wu, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Mitochondria Targeted Viral Replication and Survival Strategies—Prospective on SARS-CoV-2 |
Gatti, P, Ilamathi, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
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Genoni, G, Conio, et al |
American Journal of Perinatology |
Review Literature| Revue de littérature |
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Role of Proteolytic Enzymes In the Covid-19 Infection And Promising Therapeutic
Approaches |
Gioia, M, Ciaccio, et al |
Biochem Pharmacol |
Review Literature| Revue de littérature |
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Giralt-Herrera, A, Rojas-Velázquez, et al |
Revista Habanera de Ciencias Medicas |
Review Literature| Revue de littérature |
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Gómez Tejeda, JJ, Dieguez Guach, et al |
Revista Habanera de Ciencias Medicas |
Review Literature| Revue de littérature |
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Extra-pulmonary manifestations of the novel coronavirus infection
SARS-CoV-2 |
Gómez, OG, Gámez Leyva, et al |
Revista Habanera de Ciencias Medicas |
Review Literature| Revue de littérature |
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Gu, ZC, Zhang, et al |
Cardiovascular Diagnosis and Therapy |
Review Literature| Revue de littérature |
MA: (PubMed, Embase, Cochrane), Chinese-language databases (CNKI, VIP, WANFANG), and preprint platform were searched.
This meta-analysis showed that myocardial injury occurred in 21% of COVID-19 patients. An elevated rate was observed in non-survivors (66%) and severe patients (43%). Severe patients had a 4.74-fold increase in the risk of myocardial injury than non-severe
patients. Aggressive strategy may be considered for COVID-19 patients at high risk of myocardial injury. |
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Gupta, R, Misra, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Review Literature| Revue de littérature |
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Hafez, HM, Attia, et al |
Frontiers in Veterinary Science |
Review Literature| Revue de littérature |
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Haq, EU, Yu, et al |
Experimental Hematology and Oncology |
Review Literature| Revue de littérature |
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Havenga, M |
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Review Literature| Revue de littérature |
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Henry, B, Cheruiyot, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
MA: electronic search was carried out in PubMed, China National Knowledge Infrastructure (CNKI) and Cochrane Central
Register of Controlled Trials (CENTRAL). Admission lymphopenia and neutrophilia are associated with poor outcomes in patients with COVID-19. Regular monitoring and early and even more aggressive intervention shall hence be advisable in patients with low lymphocyte
and high neutrophil counts. |
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Hidalgo-Blanco, M, Andreu-Periz, et al |
Enfermeria Nefrologica |
Review Literature| Revue de littérature |
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Holtgrave, DR, Valdiserri, et al |
AIDS Behav |
Review Literature| Revue de littérature |
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Coronavirus disease 2019 (COVID-19): Latest developments in potential treatments |
Hon, KL, Leung, et al |
Drugs in Context |
Review Literature| Revue de littérature |
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Hu, T, Liu, et al |
PeerJ |
Review Literature| Revue de littérature |
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A review of medications used to control and improve the signs and symptoms of
COVID-19 patients |
Hushmandi, K, Bokaie, et al |
Eur J Pharmacol |
Review Literature| Revue de littérature |
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Iannarella, R, Lattanzi, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
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Jaaz, WS |
International Journal of Psychosocial Rehabilitation |
Review Literature| Revue de littérature |
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Jackowska, T, Marczyńska, et al |
Pediatria polska |
Review Literature| Revue de littérature |
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Jackowska, T, Peregud-Pogorzelski, et al |
Pediatria polska |
Review Literature| Revue de littérature |
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Jones, C, Miguel-Cruz, et al |
JMIR Mhealth Uhealth |
Review Literature| Revue de littérature |
ScR: MEDLINE (Medical Literature Analysis and Retrieval System Online), EMBASE (Excerpta Medica dataBASE), APA (American
Psychological Association) PsycINFO, CINAHL (Cumulative Index of Nursing and Allied Health Literature) Plus with Full Text, and Military & Government Collection. Digital delivery of trauma therapies for military members, veterans, and PSP is a critical area
for further research. Although promising evidence exists regarding the effectiveness of digital health within these populations, many questions remain, and a cautious approach to more widespread implementation is warranted. |
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Potential sources, modes of transmission and effectiveness of prevention measures
against SARS-CoV-2 |
Kampf, G, Brüggemann, et al |
J Hosp Infect |
Review Literature| Revue de littérature |
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32910318; Intensive Care Unit Management of the Adult with Congenital Heart Disease |
Kendsersky, P, Krasuski, et al |
Current cardiology reports |
Review Literature| Revue de littérature |
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Management principles of patients with venous thromboembolism during the COVID-19
pandemic |
Khryshchanovich, VY |
Novosti Khirurgii |
Review Literature| Revue de littérature |
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COVID-19: what are the risks for patients with sleep disorders? |
Korostovtseva, LS, Bochkarev, et al |
Arterial Hypertension (Russian Federation) |
Review Literature| Revue de littérature |
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Kravchuk, EN, Neimark, et al |
Arterial Hypertension (Russian Federation) |
Review Literature| Revue de littérature |
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Kumar, D, Sharma, et al |
International Journal of Psychosocial Rehabilitation |
Review Literature| Revue de littérature |
SR
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Review on the contamination of wastewater by COVID-19 virus: Impact and treatment |
Lahrich, S, Laghrib, et al |
Science of the Total Environment |
Review Literature| Revue de littérature |
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Larson, C, Oronsky, et al |
Biochimica et Biophysica Acta - Reviews on Cancer |
Review Literature| Revue de littérature |
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Lenihan, D, Carver, et al |
CA Cancer Journal for Clinicians |
Review Literature| Revue de littérature |
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Angiotensin-converting enzyme 2 (ACE2): COVID 19 gate way to multiple organ failure
syndromes |
Loganathan, S, Maheshkumar, et al |
Respir Physiol Neurobiol |
Review Literature| Revue de littérature |
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Ludvigsson, JF |
Acta Paediatr |
Review Literature| Revue de littérature |
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COVID-19 in patients with inflammatory bowel disease: A systematic review of clinical
data |
Macaluso, FS, Orlando, et al |
Digestive and Liver Disease |
Review Literature| Revue de littérature |
SR: PubMed Central/Medline and Embase were systemically searched for records up to May 31, 2020. This systematic review
highlighted two main points that may help clinicians dealing with IBD in reassuring their patients: (1) patients with IBD do not seem to be at higher risk of being infected by SARS-COV-2 than the general population; (2) in case of Covid-19, treatment with
immunomodulators or biologics is not associated with worse prognosis, while systemic steroids are suspected to be potentially detrimental, even if more data are needed to confirm this point. |
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MacLean, MA, Kamintsky, et al |
Fluids and barriers of the CNS |
Review Literature| Revue de littérature |
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Prospects for SARS-CoV-2 diagnostics, therapeutics and vaccines in Africa |
Margolin, E, Burgers, et al |
Nature Reviews Microbiology |
Review Literature| Revue de littérature |
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Masson-Zwaan, T |
Air and Space Law |
Review Literature| Revue de littérature |
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Mattiuzzi, C, Henry, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
MA: search was performed in Medline and Web of Science without date restrictions. Repeated molecular testing on respiratory
tracts specimens at 1 and 2 months after recovery from COVID-19 is strongly advisable for early identification, isolation and clinical management of subjects with SARS-CoV-2 recurrent RNA positivity. |
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Mishra, D, Mishra, et al |
3 Biotech |
Review Literature| Revue de littérature |
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COVID-19 associated complications and potential therapeutic targets |
Monpara, JD, Sodha, et al |
European journal of pharmacology |
Review Literature| Revue de littérature |
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Morone, G, Palomba, et al |
Frontiers in Medicine |
Review Literature| Revue de littérature |
SR: searched PubMed, EMBASE, and Web of Science up to May 5, 2020. In conclusion, medical and social communities must
pay close attention to negativization criteria for COVID-19, because patients could have longer alternative viral shedding. |
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Muhammad, SZ, Ahmed, et al |
Le infezioni in medicina |
Review Literature| Revue de littérature |
SR-MA: PubMed and EMBASE databases were systematically searched. Bilateral ground glass opacification, a subpleural
distribution of lesions, and involvement of the left lower lobe were the most notable chest CT findings in COVID-19 patients. |
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Mukherjee, S, Ray, et al |
Recent Pat Antiinfect Drug Discov |
Review Literature| Revue de littérature |
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32921730; Possible modes of transmission of Novel coronavirus SARS-CoV-2: a review |
Mukhra, R, Krishan, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
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Naderi, M, Malek, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
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NasrAllah, MM, Osman, et al |
Rev Med Virol |
Review Literature| Revue de littérature |
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Dietary supplementation and medication of vitamin c and vitamin d in covid-19 –
a hypothesis |
Nayak, S, Behera, et al |
International Journal of Pharmaceutical Research |
Review Literature| Revue de littérature |
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32921715;
Cardiovascular system is at higher risk of affecting by COVID-19 |
Nejadghaderi, SA, Heidari, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
|
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Ng, JJ, Luo, et al |
J Infect |
Review Literature| Revue de littérature |
MA: search was performed on PubMed, Embase, Scopus and Web of Science to identify articles from 1 Jan 2020 till 20
April 2020. We found that the overall risk of AKI in all hospitalized patients seemed to be low with a pooled incidence rate of 3%. This risk increases to 19% when patients are admitted to the ICU.
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Immune Response Resetting as a Novel Strategy to Overcome SARS-CoV-2-Induced Cytokine
Storm |
Nowill, AE, de Campos-Lima, et al |
J Immunol |
Review Literature| Revue de littérature |
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The 2020’s world deadliest pandemic: Corona Virus (COVID-19) and International
Medical Law (IML) |
Nueangnong, V, Hasan Subih, et al |
Cogent Social Sciences |
Review Literature| Revue de littérature |
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Neurological complications of covid-19 and possible neuroinvasion pathways: A systematic
review |
Orrù, G, Conversano, et al |
International Journal of Environmental Research and Public Health |
Review Literature| Revue de littérature |
SR: searching relevant studies on PubMed and Scopus databases. As regards the peripheral nervous system (PNS), Guillain-Barré
and Miller Fisher syndromes are the most frequent manifestations reported in the literature. Important clinical information on the neurological manifestations of SARS-CoV-2 would help clinicians raise awareness and simultaneously improve the prognosis of critically
ill patients. |
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Ortolan, A, Lorenzin, et al |
International Journal of Infectious Diseases |
Review Literature| Revue de littérature |
SR-MA: search covered the period from January 1 to April 30, 2020. Males are slightly more susceptible to SARS-CoV2
infection, present with a more severe disease, and have a worse prognosis. Further studies are warranted to unravel the biological mechanisms underlying these observations.
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Özdemir, HB, Özdek, et al |
Retina-Vitreus |
Review Literature| Revue de littérature |
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Recommendations for childcare in the face of the new coronavirus |
Pacheco, STA, Nunes, et al |
Cogitare Enfermagem |
Review Literature| Revue de littérature |
|
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Patoulias, D, Katsimardou, et al |
Current hypertension reports |
Review Literature| Revue de littérature |
SR-MA: PubMed, CENTRAL, and grey literature were searched from their inception to 19 May 2020. ACE inhibitors might
be marginally protective regarding SARS-CoV-2-related death compared with ARBs
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Paul, R, Ostermann, et al |
Biosensors and Bioelectronics |
Review Literature| Revue de littérature |
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Pérez Abreu, MR, Gómez Tejeda, et al |
Revista Habanera de Ciencias Medicas |
Review Literature| Revue de littérature |
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32911757; Polyphenols vs. Coronaviruses: How far has research moved forward? |
Piccolella, S, Crescente, et al |
Molecules |
Review Literature| Revue de littérature |
|
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32898468; Convalescent plasma therapy: a promising coronavirus disease 2019 treatment
strategy |
Piyush, R, Rajarshi, et al |
Open biology |
Review Literature| Revue de littérature |
|
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Comorbidities and clinical severity
of COVID-19: systematic review and meta-analysis |
Plasencia-Urizarri, T, Aguilera-Rodríguez, et al |
Revista Habanera de Ciencias Medicas |
Review Literature| Revue de littérature |
SR-MA: systematic literature search and meta-analysis was conducted in specialized databases to obtain information
from articles published until March 20, 2020. Chronic kidney disease, cardiovascular disease, hypertension and diabetes are among the comorbidities with the highest risk of severe clinical presentation in COVID-19 patients, followed in importance by immunodeficiency,
smoking, chronic lung disease and chronic liver disease. |
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COVID-19 and Extracellular Vesicles: An Intriguing Interplay |
Pocsfalvi, G, Mammadova, et al |
Kidney Blood Press Res |
Review Literature| Revue de littérature |
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32716669; Lower Incidence of COVID-19 at High Altitude: Facts and Confounders |
Pun, M, Turner, et al |
High altitude medicine & biology |
Review Literature| Revue de littérature |
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Facemask Alternatives in Veterinary Medicine in the Context of COVID-19 Shortages |
Purens, AGM |
Frontiers in Veterinary Science |
Review Literature| Revue de littérature |
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Purushothaman, R, Sribiju, et al |
Journal of the Indian Medical Association |
Review Literature| Revue de littérature |
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Purushothaman, S, Fung, et al |
Australasian Psychiatry |
Review Literature| Revue de littérature |
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Qureshi, MN, AlRajhi, et al |
International Journal of Pediatrics and Adolescent Medicine |
Review Literature| Revue de littérature |
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32894921; Teaching online: foundational concepts of online learning and practical guidelines |
Rhim, HC, Han, et al |
Korean journal of medical education |
Review Literature| Revue de littérature |
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Riccò, M, Ranzieri, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
SR-MA: searched Pubmed, Embase, and pre-print archive medRxiv.og for eligible studies published up to June 1st, 2020.
In conclusion, diagnostic tests based on salivary specimens are somewhat reliable, but relatively few studies have been carried out.
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Clinical aspects related to the Severe acute respiratory
syndrome (SARS-CoV-2) |
Rodríguez, JH |
Revista Habanera de Ciencias Medicas |
Review Literature| Revue de littérature |
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Saad Alharbi, K, Al-Abbasi, et al |
Alternative Therapies in Health and Medicine |
Review Literature| Revue de littérature |
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Diving after SARS-CoV-2 (COVID-19) infection: Fitness to dive assessment and medical
guidance |
Sadler, C, Alvarez Villela, et al |
Diving Hyperb Med |
Review Literature| Revue de littérature |
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Salajegheh Tazerji, S, Magalhães Duarte, et al |
J Transl Med |
Review Literature| Revue de littérature |
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Cardiovascular complications associated with COVID-19 and potential therapeutic strategies |
Samidurai, A, Das, et al |
International Journal of Molecular Sciences |
Review Literature| Revue de littérature |
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Sánchez García, NL, Velázquez, et al |
Revista Habanera de Ciencias Medicas |
Review Literature| Revue de littérature |
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Experimental Models for the Study of Central Nervous System Infection by SARS-CoV-2 |
Sanclemente-Alaman, I, Moreno-Jiménez, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Schoot, TS, Kerckhoffs, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
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Factors associated with mortality in COVID-19 patients: A systematic review and meta-analysis |
Sepandi, M, Taghdir, et al |
Iranian Journal of Public Health |
Review Literature| Revue de littérature |
SR-MA: All articles published in the period Jan 1, 2020, to Mar 23, 2020, written in English and reporting fac-tors
associated with COVID-19 mortality were reviewed. Infection with COVID-19 is associated with substantial mortality mainly in older patients with comorbidities. We found the significant effect of age, gender and comorbidities such as Diabetes Mellitus, Hy-pertension,
Kidney disorders and Heart diseases on the risk of death in patients with COVID-19.
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32845250; COVID-19: Prospective Challenges and Potential Vaccines |
Shahid Nadeem, M, Ali, et al |
Alternative Therapies in Health and Medicine |
Review Literature| Revue de littérature |
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32921716; The role of imaging and other diagnostic approaches in COVID-19 |
Shammus, R, Mahbub, et al |
Acta bio-medica : Atenei Parmensis |
Review Literature| Revue de littérature |
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Optimal Sedation and Pain Management: A Patient- and Symptom-Oriented Paradigm |
Shehabi, Y, Al-Bassam, et al |
Semin Respir Crit Care Med |
Review Literature| Revue de littérature |
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Shobha, W, Apoorva, et al |
Research Journal of Chemistry and Environment |
Review Literature| Revue de littérature |
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Shpichka, A, Bikmulina, et al |
International Journal of Bioprinting |
Review Literature| Revue de littérature |
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Mycogenic metal nanoparticles for the treatment of mycobacterioses |
Simões, MF, Ottoni, et al |
Antibiotics |
Review Literature| Revue de littérature |
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Simona, D, Lorena, et al |
Expert Rev Gastroenterol Hepatol |
Review Literature| Revue de littérature |
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Branching
processes modelling for coronavirus (COVID'19) pandemic |
Slavtchova-Bojkova, M |
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Review Literature| Revue de littérature |
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COVID-19 and its impact on space
activities: Force majeure and further legal implications |
Smith, LJ, Jung, et al |
Air and Space Law |
Review Literature| Revue de littérature |
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Snow, EK, Miller, et al |
Am J Health Syst Pharm |
Review Literature| Revue de littérature |
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Curcumin, a traditional spice component, can hold the promise against COVID-19? |
Soni, VK, Mehta, et al |
European journal of pharmacology |
Review Literature| Revue de littérature |
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Suffredini, DA, Allison, et al |
Journal of intensive care medicine |
Review Literature| Revue de littérature |
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Sukmariningsih, RM, Irwansyah |
International Journal of Psychosocial Rehabilitation |
Review Literature| Revue de littérature |
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Low-cost
technology for COVID-19 infection detection through smell loss test: An overview |
Swain, KC, Singha, et al |
Tropical Biomedicine |
Review Literature| Revue de littérature |
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Possible potential treatment strategies against novel coronavirus sars-cov-2 |
Thakur, U, Kumar, et al |
International Journal of Pharmaceutical Research |
Review Literature| Revue de littérature |
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The management of patients with neurological diseases during the COVID-19
pandemic |
Topuzova, MP, Alekseeva, et al |
Arterial Hypertension (Russian Federation) |
Review Literature| Revue de littérature |
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Tzou, PL, Tao, et al |
Viruses |
Review Literature| Revue de littérature |
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Drug Repurposing Approaches: Existing Leads For Novel Threats And Drug Targets |
Usha, T, Middha, et al |
Curr Protein Pept Sci |
Review Literature| Revue de littérature |
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COVID-19 pandemic and the measures
taken by the european union aviation safety agency |
Uva, RS, Ratajczyk, et al |
Air and Space Law |
Review Literature| Revue de littérature |
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COVID-19. From pathogenesis to high mortality in elderly patients
with comorbidities |
Valdés, MÁS |
Revista Habanera de Ciencias Medicas |
Review Literature| Revue de littérature |
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Vallejo Ardila, DL, Tamayo Cáceres, et al |
Revista Colombiana de Cardiologia |
Review Literature| Revue de littérature |
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Vallejo, BM, J, et al |
Progress in Disaster Science |
Review Literature| Revue de littérature |
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van Boekel, LC, Stoop, et al |
Tijdschrift voor gerontologie en geriatrie |
Review Literature| Revue de littérature |
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Venturelli, M, Cè, et al |
Sport Sciences for Health |
Review Literature| Revue de littérature |
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Vinayagam, S, Sattu, et al |
Life Sciences |
Review Literature| Revue de littérature |
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Vitte, J, Michel, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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A review on SARS-CoV-2 and COVID-19: Preface to prevention and management approaches |
Vyas, N, Chokshi, et al |
International Journal of Pharmaceutical Research |
Review Literature| Revue de littérature |
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Evaluation of current medical approaches for COVID-19: a systematic review and
meta-analysis |
Wang, M, Wu, et al |
BMJ Support Palliat Care |
Review Literature| Revue de littérature |
SR-MA: Online databases were searched for articles published before or on 22 June 2020. HCQ, LPV/r and Arbidol bring
little benefit in COVID-19 treatment. Integrative Chinese-Western medicine improved the clinical symptoms of patients with COVID-19. Remdesivir and CP might be the potential treatments for patients with severe COVID-19. |
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PMC7480227; Potential role of ACE2-related microRNAs in COVID-19-associated nephropathy |
Widiasta, A, Sribudiani, et al |
Noncoding RNA Res |
Review Literature| Revue de littérature |
|
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Williams, N, Radia, et al |
European journal of pediatrics |
Review Literature| Revue de littérature |
SR: searched the MEDLINE (PubMed) electronic database from December 1st 2019 to 31st May 2020. Whilst only a small
number of children suffer from COVID-19 disease compared to adults, children with comorbidities, particularly pre-existing cardiac conditions, represent a large proportion of those that became critically unwell. |
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Challenges and silver linings of COVID-19 in Ethiopia –short review |
Wondimu, W, Girma, et al |
Journal of Multidisciplinary Healthcare |
Review Literature| Revue de littérature |
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|
Wu, BB, Gu, et al |
Infect Genet Evol |
Review Literature| Revue de littérature |
SR-MA: PubMed, MedRxiv, BioRxiv,Web of Science and CNKI. The current meta-analysis suggest that blood type A might
be more susceptible to infect COVID-19 while blood type O might be less susceptible to infect COVID-19; there were no correlation between ABO blood group and severity or demise of COVID-19.
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New molecular diagnostic technologies for clinical detection of SARS-CoV-2 |
Xie, CM, Wu, et al |
Yi Chuan |
Review Literature| Revue de littérature |
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A quick look at the latest developments in the COVID-19 pandemic |
Xue, L, Li, et al |
Journal of International Medical Research |
Review Literature| Revue de littérature |
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32901762; SARS-CoV-2 infections with emphasis on pediatric patients: a narrative
review |
Yamamoto, L, Santos, et al |
Revista do Instituto de Medicina Tropical de Sao Paulo |
Review Literature| Revue de littérature |
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32921955; Etiology and management of liver injury in patients with COVID-19 |
Yang, RX, Zheng, et al |
World journal of gastroenterology |
Review Literature| Revue de littérature |
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Yilmaz, E, Akyön, et al |
Turkish Journal of Biochemistry |
Review Literature| Revue de littérature |
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Non-invasive assessment of endothelial dysfunction: A novel method to predict severe
COVID-19? |
Yoganandamoorthy, S, Munasinghe, et al |
Medical hypotheses |
Review Literature| Revue de littérature |
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Zain, NHM, Othman, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Review Literature| Revue de littérature |
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Zhang, RL, Lo, et al |
Curr Opin Pharmacol |
Review Literature| Revue de littérature |
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Zhu, C, Sun, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
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Ensuring Adequate Palliative and Hospice Care During COVID-19 Surges |
Abbott, J, Johnson, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
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Abdelhafiz, AS, Alorabi, et al |
Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Statins-based prophylactic mouthwash and nasal spray may protect against coronavirus
disease 2019 |
Abdulrab, S, Alkadasi, et al |
New Microbes and New Infections |
Commentary/Editorial| Commentaire/Éditorial |
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Abeyratne, R |
Journal of Airport Management |
Commentary/Editorial| Commentaire/Éditorial |
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32921734; The rebirth of health system in Italy after COVID-19 pandemia: starting
points |
Actis, AG, Actis, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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Ader, F |
BMJ Open |
Commentary/Editorial| Commentaire/Éditorial |
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Afra, TP, Nampoothiri, et al |
Eur J Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Afriyie, DK, Asare, et al |
Journal of infection in developing countries |
Commentary/Editorial| Commentaire/Éditorial |
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Agius, RM, Robertson, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Sustainability of airlines in India with Covid-19: Challenges ahead and possible
way-outs |
Agrawal, A |
Journal of Revenue and Pricing Management |
Commentary/Editorial| Commentaire/Éditorial |
|
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Agren, D |
Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Optimizing breast cancer surgery during the COVID-19 pandemic |
Ahmed, M |
Breast Cancer |
Commentary/Editorial| Commentaire/Éditorial |
|
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Introduction
to COVID-19, history, impact, symptoms and prevention |
Ahmed, SH, Sahi, et al |
Pakistan Journal of Medical and Health Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Ajami, S, Mohammadi, et al |
Health Policy and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Severe COVID-19 and interleukin-6 receptor antagonist tocilizumab: Some notes of concern |
Akinosoglou, K, Gogos, et al |
Respirology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Retired Plastic Surgeons as Educators During the COVID-19 Pandemic |
Al-Benna, S |
Aesthetic Plast Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
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32910671; Vulnerability and Health Care. Law and Medical Protocols |
Albert, M |
Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y Etica Medica |
Commentary/Editorial| Commentaire/Éditorial |
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Dangers of the Use of hydroxychloroquine and azithromycin combination in COVID-19
patients |
Alizargar, J |
Travel Med Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Al-Jehani, H, John, et al |
Frontiers in Neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Global challenge of health communication: Infodemia in the coronavirus disease (COVID-19)
pandemic |
Allahverdipour, H |
Journal of Education and Community Health |
Commentary/Editorial| Commentaire/Éditorial |
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The Medical Student Response to the Mental Health Consequences of COVID-19 |
Almazan, AN, Chun, et al |
Acad Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Alsayedahmed, HH |
Journal of infection in developing countries |
Commentary/Editorial| Commentaire/Éditorial |
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Amerio, A, Odone, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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Amini, S, Koolivand, et al |
Ethics Med Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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The role of psychiatrists in addressing COVID-19 conspiracy theories |
Andrade, G |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Dexamethasone, pro-resolving lipid mediators and resolution of inflammation in COVID-19 |
Andreakos, E, Papadaki, et al |
Allergy |
Commentary/Editorial| Commentaire/Éditorial |
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Antoine, B, Nicolas, et al |
Health Services Insights |
Commentary/Editorial| Commentaire/Éditorial |
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Will european union become a global power center? (Trends, opportunities,
risks) |
Arbatova, NK |
World Economy and International Relations |
Commentary/Editorial| Commentaire/Éditorial |
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Archer, C, Wolf, et al |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
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Ari, A |
Expert Opinion on Drug Delivery |
Commentary/Editorial| Commentaire/Éditorial |
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Understanding the ethical implications of the rituals of medicine |
Arnold, MH, Komesaroff, et al |
Internal Medicine Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Arroyo-Hernández, H, Quijano-Escate, et al |
Revista Cubana de Informacion en Ciencias de la Salud |
Commentary/Editorial| Commentaire/Éditorial |
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Asakura, H, Ogawa, et al |
J Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
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Aslam, N |
Pakistan Journal of Medical and Health Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Aspelund, T |
Laeknabladid |
Commentary/Editorial| Commentaire/Éditorial |
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“Missing/Unspecified”: Demographic Data Visualization During the COVID-19 Pandemic |
Atherton, R |
Journal of Business and Technical Communication |
Commentary/Editorial| Commentaire/Éditorial |
|
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Covid-19 and the challenges it poses to health professionals
in cuba |
Auza-Santiváñez, JC, Dorta-Contreras, et al |
Revista Cubana de Investigaciones Biomedicas |
Commentary/Editorial| Commentaire/Éditorial |
|
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How could we improve the national projects in health and demography after
coronavirus pandemic? |
Avxentyev, NA, Nazarov, et al |
Voprosy Ekonomiki |
Commentary/Editorial| Commentaire/Éditorial |
|
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32910442; Covid-19 and its impact on brain stimulation centres in the Lowlands |
Baeken, C |
Tijdschrift voor psychiatrie |
Commentary/Editorial| Commentaire/Éditorial |
|
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PMC7490286; Pandemic and the planning of resilient cities and regions |
Banai, R |
Cities |
Commentary/Editorial| Commentaire/Éditorial |
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Baniya, S, Potts, et al |
Journal of Business and Technical Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Bardach, SH, Gibson, et al |
Alzheimer's and Dementia: Translational Research and Clinical Interventions |
Commentary/Editorial| Commentaire/Éditorial |
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32910843; Psychiatric Medical Education in the Age of COVID-19: The Penn State Health
Experience |
Batchelder, E, Piper, et al |
The primary care companion for CNS disorders |
Commentary/Editorial| Commentaire/Éditorial |
|
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32910871; Excess mortality: the gold standard in measuring the impact of COVID-19
worldwide? |
Beaney, T, Clarke, et al |
Journal of the Royal Society of Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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The pandemic academy: Reflections of infectious diseases fellows during COVID-19 |
Beh, DLL, Ng, et al |
Open Forum Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Bejjani, A, Burt, et al |
JCO clinical cancer informatics |
Commentary/Editorial| Commentaire/Éditorial |
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32921746; Surgical activity organization during COVID-19 outbreak: a teaching hospital
experience |
Bellini, V, Cozzani, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
|
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Bellizzi, S, Pichierri, et al |
Journal of Global Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Bellver, V |
Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y Etica Medica |
Commentary/Editorial| Commentaire/Éditorial |
|
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The coronavirus
(COVID-19) pandemic in Australia – history and potential lessons |
Beran, RG |
Medicine and law |
Commentary/Editorial| Commentaire/Éditorial |
|
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PMC7492799; How menaquinone-7 deficiency influences mortality and morbidity among
COVID-19 patients |
Berenjian, A, Sarabadani, et al |
Biocatal Agric Biotechnol |
Commentary/Editorial| Commentaire/Éditorial |
|
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Bersanelli, M |
Immunotherapy |
Commentary/Editorial| Commentaire/Éditorial |
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Factors associated with increased morbidity and mortality of obese and overweight COVID-19
patients |
Beshbishy, AM, Hetta, et al |
Biology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Julian of norwich (1342–ca.1416) as a post-scholastic theologian |
Beukes, J |
HTS Teologiese Studies / Theological Studies |
Commentary/Editorial| Commentaire/Éditorial |
|
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32707182; Novel Temperature Trajectory Subphenotypes in COVID-19 |
Bhavani, SV, Huang, et al |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
|
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32921743; Using video presentation to recruit healthcare workers during COVID-19
pandemic |
Binda, F, Bisesti, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
|
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Automation and Reallocation:Will COVID-19 Usher in the Future ofWork? |
Blit, J |
Canadian Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Is Interleukin 6 the Right Target in COVID-19 Severe Pneumonia? |
Blot, M, Bourredjem, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Blum, K, Cadet, et al |
Subst Use Misuse |
Commentary/Editorial| Commentaire/Éditorial |
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Bluro, IM, Piñeiro, et al |
Global Heart |
Commentary/Editorial| Commentaire/Éditorial |
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Bobrova, L, Kozlovskaya, et al |
Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Is the role of forensic medicine in the covid-19 pandemic underestimated? |
Bogdanović, M, Atanasijević, et al |
Forensic Sci Med Pathol |
Commentary/Editorial| Commentaire/Éditorial |
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Boland, MG |
Hawai'i journal of health & social welfare |
Commentary/Editorial| Commentaire/Éditorial |
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Bordet, J, Perrier, et al |
Eur J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Borisov, VV |
Urologiia (Moscow, Russia : 1999) |
Commentary/Editorial| Commentaire/Éditorial |
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Does the Coronavirus Epidemic Take Advantage of Human Optimism Bias? |
Bottemanne, H, Morlaàs, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Cities and the climate and ecological emergency:
The liverpool city region response |
Boyle, M, Crone, et al |
Journal of Urban Regeneration and Renewal |
Commentary/Editorial| Commentaire/Éditorial |
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The Consequences of the COVID-19 Lockdown on Stalking Victimisation |
Bracewell, K, Hargreaves, et al |
Journal of Family Violence |
Commentary/Editorial| Commentaire/Éditorial |
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Digital Clinical Trials for Substance Use Disorders in the Age of Covid-19 |
Brezing, CA, Luo, et al |
J Addict Med |
Commentary/Editorial| Commentaire/Éditorial |
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Encouraging adoption of protective behaviors to mitigate the spread of COVID-19 |
Brossard, D, Wood, et al |
Encouraging Adoption of Protective Behaviors to Mitigate the Spread of COVID-19 |
Commentary/Editorial| Commentaire/Éditorial |
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Brunsvig Jarvis, K, Lind, et al |
Acta Paediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Safety and efficacy of the Russian COVID-19 vaccine: more information needed |
Bucci, Enrico, Andreev, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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Modelling Threat Causation for Religiosity and Nationalism in Europe |
Bullock, Josh, Lane, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Political will and intersectorality to confront COVID-19 in
Cuba |
Caballero, RL |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
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Cai, Q, Chen, et al |
Diabetes care |
Commentary/Editorial| Commentaire/Éditorial |
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Telemedicine implementation in family medicine: Undergraduate clerkship during COVID-19
pandemic |
Cain, R, Shafer Klink, et al |
Med Educ |
Commentary/Editorial| Commentaire/Éditorial |
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The use of mesenchymal stromal cells in the treatment of coronavirus disease 2019 |
Canham, MA, Campbell, et al |
J Transl Med |
Commentary/Editorial| Commentaire/Éditorial |
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Cariou, B, Hadjadj, et al |
Diabetes care |
Commentary/Editorial| Commentaire/Éditorial |
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32919427; Gastrointestinal endoscopy during extracorporeal membrane oxygenation (ECMO)
for COVID-19 |
Casper, M, Lepper, et al |
Journal of gastrointestinal and liver diseases : JGLD |
Commentary/Editorial| Commentaire/Éditorial |
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Evolution or devolution: Aviation
law and practice after COVID-19 |
Cassar, R |
Air and Space Law |
Commentary/Editorial| Commentaire/Éditorial |
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Cattaruzza, MS, Gorini, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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Anakinra for COVID-19: how to interpret elevations in serum liver enzymes |
Cavalli, G, Dagna, et al |
Arthritis Rheumatol |
Commentary/Editorial| Commentaire/Éditorial |
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32921711; An Outbreak of Kawasaki-like Disease in children during SARS-CoV- 2 Epidemic:
No Surprise? |
Cavallo, F, Chiarelli, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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Cervino, G, Fiorillo, et al |
Data |
Commentary/Editorial| Commentaire/Éditorial |
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Importance of Dietary Changes During the Coronavirus Pandemic: How to Upgrade Your
Immune Response |
Chaari, A, Bendriss, et al |
Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Chadwick, D |
Physiologist |
Commentary/Editorial| Commentaire/Éditorial |
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Host tolerance contributes to persistent viral shedding in COVID-19 |
Chang, D, Chen, et al |
EClinicalMedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Chaple, ERB |
Revista Cubana de Informacion en Ciencias de la Salud |
Commentary/Editorial| Commentaire/Éditorial |
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Research Note–The New Frontier of Enhanced Terrorism with the United States
In Mind |
Chasdi, RJ |
International Journal of Intelligence, Security, and Public Affairs |
Commentary/Editorial| Commentaire/Éditorial |
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Chatterjee, S, Biswas, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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The SARS-CoV-2 crisis and its impact on neglected tropical diseases: Threat or
opportunity? |
Chaumont, C, Kamara, et al |
PLoS Negl Trop Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Cheema, S, Ameduri, et al |
Epidemiol Infect |
Commentary/Editorial| Commentaire/Éditorial |
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Chen, Q, Huang, et al |
American Journal of Managed Care |
Commentary/Editorial| Commentaire/Éditorial |
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Chen, Y, Yang, et al |
Diabetes care |
Commentary/Editorial| Commentaire/Éditorial |
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32897383; COVID-19 Transmission Conclusions Justified by the Analysis Results?-Reply |
Cheng, HY, Ng, et al |
JAMA internal medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Chesak, SS, Perlman, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Cheshmehzangi, A |
Round Table |
Commentary/Editorial| Commentaire/Éditorial |
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Chinese Neonatologist Association, Chinese Medical, Doctor Association, et al |
Chinese Journal of Perinatal Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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32923351; Cardiometabolic Health: Key in Reducing Adverse COVID-19 Outcomes |
Chowdhury, R, van Daalen, et al |
Global heart |
Commentary/Editorial| Commentaire/Éditorial |
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Chua, H, Lim, et al |
Anesthesia and Analgesia |
Commentary/Editorial| Commentaire/Éditorial |
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Cid, MFB, Fernandes, et al |
Multidisciplinary Journal of Educational Research |
Commentary/Editorial| Commentaire/Éditorial |
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Turkish University libraries during Novel Coronavirus (COVID-19) pandemic |
Çi̇Men, E, Gürdal, et al |
Bilgi Dunyasi |
Commentary/Editorial| Commentaire/Éditorial |
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Social and institutional Reactions to the Influenza Pandemic of 1918-20 |
Cohn, SK |
Medicine, Conflict and Survival |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and obesity: The intersection between a pandemic and an epidemic in a developing
country |
Concepción-Zavaleta, MJ, Gutiérrez-Ortiz, et al |
Obesity (Silver Spring) |
Commentary/Editorial| Commentaire/Éditorial |
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Conley, D, Burroughs, et al |
Communication and the Public |
Commentary/Editorial| Commentaire/Éditorial |
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Conly, J, Seto, et al |
Antimicrobial resistance and infection control |
Commentary/Editorial| Commentaire/Éditorial |
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Conti, L, Grassi, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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Corrêa, HL, Corrêa, et al |
Frontiers in Materials |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2 pandemic in the mediterranean area: Epidemiology and perspectives |
Costantino, C, Cannizzaro, et al |
EuroMediterranean Biomedical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Sars-cov-2 detection for diagnosis purposes in the setting of a molecular biology research
lab |
Coupeau, D, Burton, et al |
Methods and Protocols |
Commentary/Editorial| Commentaire/Éditorial |
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Telemedicine Consultations and Follow-up of Patients With COVID-19 |
Crane, SJ, Ganesh, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Relationship between renin-angiotensin
system and novel coronavirus infection (COVID-19) |
Crombet, JS, Sanchén, et al |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
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Potential therapeutic use of RNA interference against COVID-19 |
Cuello Almarales, DA, Almaguer Mederos, et al |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
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Immunopsychiatry and SARS-CoV-2 pandemic: Links and possible consequences |
Daaboul, J, Tamouza, et al |
Encephale |
Commentary/Editorial| Commentaire/Éditorial |
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Dahal, M, Khanal, et al |
Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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32830825; COVID-19 in a young liver transplant recipient: caution for drug-drug interactions |
Dajti, E, Cristini, et al |
Journal of gastrointestinal and liver diseases : JGLD |
Commentary/Editorial| Commentaire/Éditorial |
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D'Alò, GL, Cicciarella Modica, et al |
Travel Medicine and Infectious Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Daniels, CE, Brown, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Brazilian
report on the coronavirus crisis: A clash of pandemics |
Dantas, E |
Medicine and law |
Commentary/Editorial| Commentaire/Éditorial |
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Das, A, Mitra, et al |
European Archives of Oto-Rhino-Laryngology |
Commentary/Editorial| Commentaire/Éditorial |
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de Bortoli Cassiani, SH, Munar Jimenez, et al |
Revista Panamericana de Salud Publica/Pan American Journal of Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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de Montalvo Jääskeläinen, F |
Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y Etica Medica |
Commentary/Editorial| Commentaire/Éditorial |
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32921744; The Telematic solutions in plastic surgery during COVID-19 pandemic |
De Santis, G, Palladino, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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Deacon, DC, Madigan, et al |
JAAD Case Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Suggestions
for physical exercise at home for adults during confinement due to the SARS-CoV-2 virus |
del Castillo, LAE |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
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Delamater, AM, Miller, et al |
Transl Behav Med |
Commentary/Editorial| Commentaire/Éditorial |
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Demertzis, N, Eyerman, et al |
American Journal of Cultural Sociology |
Commentary/Editorial| Commentaire/Éditorial |
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Surviving the COVID-19 menace: A case of higher education sector |
Dhamija, A |
International Journal of Psychosocial Rehabilitation |
Commentary/Editorial| Commentaire/Éditorial |
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Díaz Colina, JA |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
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Díaz-Casañas, E, Rodríguez-Moya, et al |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
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Díaz-Rodríguez, YL, Quintana-López, et al |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
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32917614; A "Global Safety Net" to reverse biodiversity loss and stabilize Earth's
climate |
Dinerstein, E, Joshi, et al |
Science advances |
Commentary/Editorial| Commentaire/Éditorial |
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Misrepresenting COVID-19: Lying With Charts During the Second Golden Age of Data
Design |
Doan, S |
Journal of Business and Technical Communication |
Commentary/Editorial| Commentaire/Éditorial |
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32905290; Highlights from ASCO 2020: updates on the treatment of chronic lymphocytic leukemia |
Dolan, S, Christofides, et al |
Current oncology (Toronto, Ont.) |
Commentary/Editorial| Commentaire/Éditorial |
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Domico, M, McCanta, et al |
HeartRhythm Case Reports |
Commentary/Editorial| Commentaire/Éditorial |
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Dong, C, Cao, et al |
Child Youth Serv Rev |
Commentary/Editorial| Commentaire/Éditorial |
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32889221; Reduction of allergic rhinitis symptoms with face mask usage during the
COVID-19 pandemic |
Dror, AA, Eisenbach, et al |
Journal of Allergy and Clinical Immunology: In Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Du, G, Zhang, et al |
Journal of Clinical Outcomes Management |
Commentary/Editorial| Commentaire/Éditorial |
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Du, L, Chen, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Development of Full-Nutritional Formula Food for COVID-19 and Respiratory
Patients |
Duan, S, Chen, et al |
Journal of Food Science and Technology (China) |
Commentary/Editorial| Commentaire/Éditorial |
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Dubbink, JH, Branco, et al |
Travel Medicine and Infectious Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Dube, B |
Multidisciplinary Journal of Educational Research |
Commentary/Editorial| Commentaire/Éditorial |
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DuBois, RN |
Cancer Prev Res (Phila) |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Government must learn lessons from deaths before winter, say MPs and peers |
Dyer, C |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Minorities account for 78% of US deaths in under 21s, says CDC |
Dyer, O |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Dyer, O |
BMJ (Clinical research ed.) |
Commentary/Editorial| Commentaire/Éditorial |
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Managing Gender Care in Precarity: Trans Communities Respond to COVID-19 |
Edenfield, AC |
Journal of Business and Technical Communication |
Commentary/Editorial| Commentaire/Éditorial |
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32923354; Impact of the COVID-19 Pandemic on Cardiologists in a Country with Limited Resources |
Elhadi, M, Alsoufi, et al |
Global heart |
Commentary/Editorial| Commentaire/Éditorial |
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Elhassan, R, Sharif, et al |
Irish medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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Elli, L, Tontini, et al |
Journal of gastrointestinal and liver diseases : JGLD |
Commentary/Editorial| Commentaire/Éditorial |
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32914858; Telemedicine for Chronic Pain in the COVID-19 Era and Beyond |
Emerick, T, Alter, et al |
Pain medicine (Malden, Mass.) |
Commentary/Editorial| Commentaire/Éditorial |
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Missed Opportunities? Covid-19, Biosecurity and One Health in the United Kingdom |
Enticott, G, Maye, et al |
Frontiers in Veterinary Science |
Commentary/Editorial| Commentaire/Éditorial |
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Contributions of psychology in the context of the COVID-19 pandemic: Thematic
section |
Enumo, SRF, Linhares, et al |
Estudos de Psicologia (Campinas) |
Commentary/Editorial| Commentaire/Éditorial |
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32910673; An ethical Response in the Care of Nursing Homes in the COVID-19 Pandemic |
Equipo Covid Residencias, Area de Salud, Valladolid Oeste |
Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y Etica Medica |
Commentary/Editorial| Commentaire/Éditorial |
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Gazi Medical
Journal – Eczacılık Fakültesi COVID-19 Özel Sayısı Önsözü |
Erdoğan Orhan, İ, Yıldız, et al |
Gazi Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Erotokritou, C, Grigorieff, et al |
Air and Space Law |
Commentary/Editorial| Commentaire/Éditorial |
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Esperón, JMT |
Revista cubana de enfermeria |
Commentary/Editorial| Commentaire/Éditorial |
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Fan, KS, Ghani, et al |
BMJ open |
Commentary/Editorial| Commentaire/Éditorial |
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Fanaroff, AA, Fanaroff, et al |
American Journal of Perinatology |
Commentary/Editorial| Commentaire/Éditorial |
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Prevalence of Chronic Disease in Laboratory-Confirmed COVID-19 Cases and U.S. Adults (2017-2018) |
Fang, M, Wang, et al |
Diabetes care |
Commentary/Editorial| Commentaire/Éditorial |
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Farahani, F, Mirzaei, et al |
International Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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A Decision-Making Algorithm for Children With Suspected Coronavirus Disease
2019 |
Feketea, GM, Vlacha, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Felipe, J, Fullwiler, et al |
Asian Development Review |
Commentary/Editorial| Commentaire/Éditorial |
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Fenwick, M, McCahery, et al |
European Business Organization Law Review |
Commentary/Editorial| Commentaire/Éditorial |
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Empathy
and mental health in the context of pandemic by COVID-19 |
Fernandes, MA, Araújo, et al |
Revista cubana de enfermeria |
Commentary/Editorial| Commentaire/Éditorial |
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Comment Regarding Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and
Immune Responses |
Ferranti, JF, Degaspare, et al |
J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Fezzi, Carlo, Fanghella, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and the liver: What do we know after six months of the pandemic? |
Fierro, NA |
Ann Hepatol |
Commentary/Editorial| Commentaire/Éditorial |
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Fitzpatrick, P |
Ir J Med Sci |
Commentary/Editorial| Commentaire/Éditorial |
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Educational purgatory: Medical education in
the era of covid-19 |
Fong, J, Lu, et al |
British Columbia Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Fooladi, EC |
Science and Education |
Commentary/Editorial| Commentaire/Éditorial |
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Foster, J, Hodder, et al |
Ann Work Expo Health |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and catastrophe capitalism commodity chains and ecological-epidemiological-economic
crises |
Foster, JB, Suwandi, et al |
Monthly Review |
Commentary/Editorial| Commentaire/Éditorial |
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Freeman, MC, Caruso, et al |
Environmental health perspectives |
Commentary/Editorial| Commentaire/Éditorial |
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eConsult
Data Shed Light on Care Coordination Decisions during the COVID-19 Pandemic |
Frencher, S, Baqai, et al |
Journal of Clinical Outcomes Management |
Commentary/Editorial| Commentaire/Éditorial |
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Context, field and landscape of audiovisual translation in the Arab
world |
Gamal, MY |
ESSACHESS - Journal for Communication Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Gangadharamurthy, D |
Journal of Nuclear Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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AntagomiRs: A novel therapeutic strategy for challenging COVID-19 cytokine storm |
Gangemi, S, Tonacci, et al |
Cytokine and Growth Factor Reviews |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19. The need of new paradigms of cooperation
and risk to health workers |
Garcell, HG |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
|
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Garcell, HG |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of the COVID-19 pandemic on ophthalmic emergency services in a tertiary hospital
in Spain |
García Lorente, M, Zamorano Martín, et al |
Eur J Ophthalmol |
Commentary/Editorial| Commentaire/Éditorial |
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García Sánchez, E |
Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y Etica Medica |
Commentary/Editorial| Commentaire/Éditorial |
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Evaluation of the COVID-19 response in Spain: principles and requirements |
García-Basteiro, AlbertoL, Legido-Quigley, et al |
The Lancet Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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32745501; Effects of the COVID-19 Pandemic on Active Non-COVID Clinical Trials |
Gaudino, M, Arvind, et al |
Journal of the American College of Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Acute new-onset symptomatic seizures in the context of mild COVID-19 infection |
Gaughan, M, Connolly, et al |
Journal of neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Pulmonary rehabilitation in COVID-19 pandemic era: The need for a revised approach |
Gautam, AP, Arena, et al |
Respirology |
Commentary/Editorial| Commentaire/Éditorial |
|
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32899439; Genetic Hypothesis and Pharmacogenetics Side of Renin-Angiotensin-System in
COVID-19 |
Gemmati, D, Tisato, et al |
Genes |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ghosh, A |
Asia Pac Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Extended lockdown and India's alcohol policy: a qualitative analysis of newspaper
articles |
Ghosh, A, Choudhury, et al |
International Journal of Drug Policy |
Commentary/Editorial| Commentaire/Éditorial |
|
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PMC7490627; qRT-PCR Platforms for Diagnosing and Reporting SARS-CoV-2 Infection
in Human Samples |
Giadone, RM, Mithal, et al |
STAR Protoc |
Commentary/Editorial| Commentaire/Éditorial |
|
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Gilkey, MB, Bednarczyk, et al |
Journal of Adolescent Health |
Commentary/Editorial| Commentaire/Éditorial |
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Giménez-Candela, M |
Derecho Animal |
Commentary/Editorial| Commentaire/Éditorial |
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The ongoing health crisis shakes the foundations of the management of natural life |
Giménez-Candela, M |
Derecho Animal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Giudici, P, Raffinetti, et al |
Frontiers in Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Zum Beitrag „Mütter-Screening in einem COVID-19-Niedrig-Pandemiegebiet“ |
Glocker, MO |
Dtsch Med Wochenschr |
Commentary/Editorial| Commentaire/Éditorial |
|
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Glynn, E, Ryan, et al |
Irish medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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Godbout, L, Genest-Grégoire, et al |
Canadian Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: What's in a name? Isolating the term "quarantine" from other contamination |
Goh, S |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
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Editorial: Unprecedented times? Social work and society post-COVID-19 |
Golightley, M, Holloway, et al |
British Journal of Social Work |
Commentary/Editorial| Commentaire/Éditorial |
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32910674; Ethical reflections on the Measures Taken in Nursing Homes During Pandemic |
Gómez Martínez, C |
Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y Etica Medica |
Commentary/Editorial| Commentaire/Éditorial |
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Gonzales, G, Loret de Mola, et al |
Journal of Adolescent Health |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7492147; Risks, resilience, and pathways to sustainable aviation: A COVID-19
perspective |
Gössling, S |
J Air Transp Manag |
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Current and Future Implications of COVID-19 on Gastroenterology Training and Clinical Practice |
Goyal, H, Gajendran, et al |
Int J Clin Pract |
Commentary/Editorial| Commentaire/Éditorial |
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Can raman spectroscopy
be a useful tool in the fight against COVID-19? |
Graham, D |
Spectroscopy (Santa Monica) |
Commentary/Editorial| Commentaire/Éditorial |
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Greener, SL |
Interactive Learning Environments |
Commentary/Editorial| Commentaire/Éditorial |
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Grotheer, Rachel, Huang, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Guba, VP, Belyutin, et al |
Teoriya i Praktika Fizicheskoy Kultury |
Commentary/Editorial| Commentaire/Éditorial |
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Gudipati, S, Zervos, et al |
Antibiotics |
Commentary/Editorial| Commentaire/Éditorial |
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Guerrero, S |
Granja |
Commentary/Editorial| Commentaire/Éditorial |
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Guna, TP, Rilna, et al |
Br J Oral Maxillofac Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Playbook for labour policies for novel shocks such as COVID-19 |
Gunderson, M |
Canadian Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
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A Decision-Making Algorithm for Children With Suspected Coronavirus Disease
2019 |
Ha, L, Mizrahi, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Haanappel, PPCP |
Air and Space Law |
Commentary/Editorial| Commentaire/Éditorial |
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Can students safely return to school in the age of COVID-19? |
Hageman, JR |
Pediatric annals |
Commentary/Editorial| Commentaire/Éditorial |
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Library strategic planning after COVID-19: Don’t fight the last war |
Hall, RA |
College and Research Libraries News |
Commentary/Editorial| Commentaire/Éditorial |
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32541247; Hypotension, systemic inflammatory response syndrome, and COVID-19:
A clinical conundrum |
Hanidziar, D, Bittner, et al |
Anesthesia and Analgesia |
Commentary/Editorial| Commentaire/Éditorial |
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Hanley, D |
Air and Space Law |
Commentary/Editorial| Commentaire/Éditorial |
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Harris, A, Jones, et al |
School Leadership and Management |
Commentary/Editorial| Commentaire/Éditorial |
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Hasanreisoglu, M, Hasanreisoglu, et al |
Retina-Vitreus |
Commentary/Editorial| Commentaire/Éditorial |
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He, Z, Li, et al |
Diabetes care |
Commentary/Editorial| Commentaire/Éditorial |
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Heilbrun, K, Burke, et al |
Journal of the American Academy of Psychiatry and the Law |
Commentary/Editorial| Commentaire/Éditorial |
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Cardiopulmonary exercise and the risk of aerosol generation while wearing a surgical
mask |
Helgeson, SA, Taylor, et al |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
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Hernández-Calle, D, Martínez-Alés, et al |
The Journal of clinical psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Ho, KHM, Smith, et al |
J Clin Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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Protecting Pandemic Conversations: Tracing Twitter’s Evolving Content Policies During
COVID-19 |
Hope, L |
Journal of Business and Technical Communication |
Commentary/Editorial| Commentaire/Éditorial |
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Horner, JackK, Symons, et al |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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32897381; COVID-19 Transmission Conclusions Justified by the Analysis Results? |
Hu, FC |
JAMA internal medicine |
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Huang, CF, Tay, et al |
The European respiratory journal |
Commentary/Editorial| Commentaire/Éditorial |
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Hussain, FN, Al-Mannai, et al |
Medical Science Educator |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2 Treatment Approaches: Numerous Options, No Certainty for a Versatile Virus |
Iacob, S, Iacob, et al |
Frontiers in Pharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Testing service wasn't prepared for increased demand, chief admits |
Iacobucci, G |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Iglesias-Osores, S |
Revista Habanera de Ciencias Medicas |
Commentary/Editorial| Commentaire/Éditorial |
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Ip, V, Tham, et al |
Anesthesia and Analgesia |
Commentary/Editorial| Commentaire/Éditorial |
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32921727; COVID-19 and Type 1 Diabetes: Concerns and Challenges |
Iughetti, L, Trevisani, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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Resumption of Otolaryngology Surgical Practice in the Setting of Regionally Receding
COVID-19 |
Izreig, S, Zogg, et al |
Otolaryngol Head Neck Surg |
Commentary/Editorial| Commentaire/Éditorial |
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32912398; COVID-19: ensuring continuity of TB services in the private sector |
Jamal, WZ, Habib, et al |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and
Lung Disease |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19:
Pharmaco-therapeutical management in uncertain situations |
Javier, CHF, David, et al |
European Journal of Clinical Pharmacy |
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On reading richard preston’s
the hot zone during the covid-19 pandemic |
Jenei, K |
British Columbia Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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32917604; Continuous on-body sensing for the COVID-19 pandemic: Gaps and opportunities |
Jeong, H, Rogers, et al |
Science advances |
Commentary/Editorial| Commentaire/Éditorial |
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Jeong, L, Smith, et al |
Medical Science Educator |
Commentary/Editorial| Commentaire/Éditorial |
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John, J, Kesner, et al |
South African Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and Black America: The intersection of health equity and the NP
workforce |
Johnson, R, Scott, et al |
Nurse Pract |
Commentary/Editorial| Commentaire/Éditorial |
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Jomo, KS |
Indian Journal of Labour Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Jones-Nosacek, C |
Linacre Quarterly |
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Joseph, NT, Wylie, et al |
Bjog |
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Decline in invasive pneumococcal disease during COVID-19 pandemic in Taiwan |
Juan, HC, Chao, et al |
J Infect |
Commentary/Editorial| Commentaire/Éditorial |
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Julián-Jiménez, A, García, et al |
Emergencias |
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Jung, Y, Novikova, et al |
Journal of Contemporary Eastern Asia |
Commentary/Editorial| Commentaire/Éditorial |
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Economic implication of a novel
disease outbreak understanding its genesis |
Kalita, U, Hazarika, et al |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Child abuse and
neglect in the covid-19 era: A primer for front-line physicians in British Columbia |
Kang, KT, Jain, et al |
British Columbia Medical Journal |
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Karampelas, M, Dalamaga, et al |
Ophthalmol Ther |
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Karos, K, McParland, et al |
Pain |
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Katner, A, Brisolara, et al |
New Solut |
Commentary/Editorial| Commentaire/Éditorial |
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Katsikopoulos, PV |
Mind and Society |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 pandemic challenges and lessons learned by pharmacy educators around the globe |
Kawaguchi-Suzuki, M, Nagai, et al |
American Journal of Pharmaceutical Education |
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Turning crisis into opportunity for transformation: Understand the world and
discover unknown value |
Kawazoe, K |
NTT Technical Review |
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32921740; Treatments for COVID-19: emerging drugs against the coronavirus |
Khademolhosseini, S, Kavandi, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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Outbreak of methanol-induced optic neuropathy amid COVID-19 pandemic |
Khalili, MR, Sadati, et al |
Graefe's Archive for Clinical and Experimental Ophthalmology |
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Khan, S |
City and Society |
Commentary/Editorial| Commentaire/Éditorial |
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The contribution of the observational research design to COVID-19 research |
Kim, AlfredHJ, Eisen, et al |
The Lancet Rheumatology |
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Crisis into
Opportunity: Can COVID-19 Help Set a Path to Improved Health Care Efficiency? |
Kim, DD, Ollendorf, et al |
American Journal of Managed Care |
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Kim, J, Ashihara, et al |
International Journal of Environmental Research and Public Health |
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32910031; Maintaining a Focus on the "Mundane" and Extraordinary During COVID-19 |
Kitto, S |
The Journal of continuing education in the health professions |
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Kligler-Vilenchik, N, Literat, et al |
Media and Communication |
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Is there an under-representation of skin of colour images during the COVID-19 outbreak? |
Kluger, N, Samimi, et al |
Medical hypotheses |
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[Most important vaccinations in patients with rheumatological diseases and why] |
Kneitz, C, Müller-Ladner, et al |
Z Rheumatol |
Commentary/Editorial| Commentaire/Éditorial |
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Ko, F |
Journal of Clinical Outcomes Management |
Commentary/Editorial| Commentaire/Éditorial |
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Koch, C, Okamura, et al |
Econ Lett |
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PMC7480226; Understanding the COVID-19 tourist psyche: The Evolutionary Tourism
Paradigm |
Kock, F, Nørfelt, et al |
Ann Tour Res |
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Legal nature of contract for provision of state medical services |
Kolisnykova, HV, Lekhkar, et al |
Journal of Advanced Research in Law and Economics |
Commentary/Editorial| Commentaire/Éditorial |
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32912396; COVID-19 in Africa: community and digital technologies for tuberculosis management |
Koura, KG, Harries, et al |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and
Lung Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Corticosteroid-related in-hospital hyperglycemia: does it negate mortality benefits in
COVID-19? |
Kow, CS, Hasan, et al |
Clin Infect Dis |
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The use of antimotility drugs in COVID-19 associated diarrhea |
Kow, CS, Hasan, et al |
J Infect |
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32921745; Novel Coronavirus (SARS-CoV-2) resistance in African populations: A cause
worth exploring |
Krishan, K, Kanchan, et al |
Acta bio-medica : Atenei Parmensis |
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Kulkarni, RK, Kinikar, et al |
Journal of Nepal Paediatric Society |
Commentary/Editorial| Commentaire/Éditorial |
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Kumar, A, Kumar, et al |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Role of graphene in biosensor and protective textile against viruses |
Kumar, A, Sharma, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 vaccinations in patients with inflammatory bowel disease |
Kumar, Aditi, Quraishi, et al |
The Lancet Gastroenterology & Hepatology |
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Kurosu, M |
Medicine and law |
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Kwon, CY, Lee, et al |
Asian Journal of Psychiatry |
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The role of carbon monoxide and heme oxygenase-1 in COVID-19 |
Kwong, KK, Chan, et al |
Toxicology Reports |
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32900165; Covid-19: Evidens-, eminens-, eller erfaringsbasert behandling? |
Laake, JH, Aasmundstad, et al |
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke |
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Łacko, A, Maciejczyk, et al |
Nowotwory |
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Lagu, T, Artenstein, et al |
Journal of Hospital Medicine |
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Lai, YJ, Chang, et al |
Journal of the Chinese Medical Association |
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Lal, S, Khan, et al |
Anaesthesia, Pain and Intensive Care |
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Lami, F, Scalabrini, et al |
Acta bio-medica : Atenei Parmensis |
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Lara, PC, Nguyen, et al |
Aging and Disease |
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Larsen, DA, Wigginton, et al |
Nat Biotechnol |
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32918807; Vitamin D: A Nutrient To Bring To Light During COVID-19 |
LaValle, JB |
Alternative Therapies in Health and Medicine |
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32914745; First autochthonous dengue outbreak in Italy, August 2020 |
Lazzarini, L, Barzon, et al |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
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32909958; Should countries aim for elimination in the covid-19 pandemic? |
Lee, A, Thornley, et al |
BMJ (Clinical research ed.) |
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Lee, S, Kim, et al |
Disability and Society |
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Lellis-Santos, C, Abdulkader, et al |
Adv Physiol Educ |
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Expert discusses the impact of COVID-19 on patients with
diabetes |
Lentile, G, Cox, et al |
Drug Topics |
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Excess pneumonia and influenza death as herald wave of COVID-19 in England and
Wales, United Kingdom |
Li, C, Zhang, et al |
J Infect |
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32913008; Vimentin as a target for the treatment of COVID-19 |
Li, Z, Paulin, et al |
BMJ open respiratory research |
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Teleorthopedic: A Promising Option During and After the Coronavirus Disease 2019
(COVID-19) Pandemic |
Lim, MA, Pranata, et al |
Frontiers in Surgery |
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Lima, WG, Brito, et al |
Phytother Res |
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Possibilities
of rehabilitation in corona virus disease (COVID-19) |
Liska, D, Poljak, et al |
Rehabilitacia |
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Paying close attention to diabetic patients with novel coronavirus infection |
Liu, B, Liu, et al |
Chinese Journal of Endocrinology and Metabolism |
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Liu, M, Zhu, et al |
Medicine (Baltimore) |
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Liu, X, Zhuang, et al |
Environ Health Prev Med |
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Safety and efficacy of the Russian COVID-19 vaccine: more information needed
– Authors’ reply |
Logunov, DenisY, Dolzhikova, et al |
The Lancet |
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Negative impact of the COVID-19 pandemic on the management of cervical cancer patients
in Zambia |
Lombe, D, Phiri, et al |
ecancermedicalscience |
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32912395; A decrease in tuberculosis evaluations and diagnoses during the COVID-19 pandemic |
Louie, JK, Reid, et al |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and
Lung Disease |
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Love Benbow, M, Kant, et al |
BMJ Simulation and Technology Enhanced Learning |
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Lu, L, Lankala, et al |
Cultural Studies - Critical Methodologies |
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Lucini, D, Gandolfi, et al |
Acta bio-medica : Atenei Parmensis |
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Lung, T, Kazatchkine, et al |
Transfusion and Apheresis Science |
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Mahase, E |
Bmj |
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Mahendran, K, Yogarajah, et al |
Eur J Dent Educ |
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Mahmoudi, S, Rezaei, et al |
J Clin Immunol |
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Mandal, AKJ, Baktash, et al |
Aging Clin Exp Res |
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Manuel, LTJ |
European Journal of Clinical Pharmacy |
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32910668; With or without COVID: a Tale on Human Vulnerability |
Marcos, A |
Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y Etica Medica |
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Marcus, RE |
Clin Orthop Relat Res |
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32920585; Stroke as a complication of Coronavirus disease 2019 (COVID-19) |
Marín-Medina, DS, Orozco-Hernández, et al |
Le infezioni in medicina |
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COVID-19
confrontation: Some precautions needed to reduce the risks |
Martínez, MG, Millán Marcelo, et al |
Revista Habanera de Ciencias Medicas |
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Masterson, M |
International Journal of Emerging Technologies in Learning |
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Mastrolia, MV, Agostiniani, et al |
Ann Rheum Dis |
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Committee opinion on imaging with radiation exposure in pregnancy |
Maternal, Fetal Experts Committee, Chinese Physician Society, et al |
Chinese Journal of Perinatal Medicine |
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Maxton, F, Darbyshire, et al |
J Clin Nurs |
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32541255; Revisiting the protein C pathway: An opportunity for adjunctive intervention
in COVID-19? |
Mazzeffi, M, Chow, et al |
Anesthesia and Analgesia |
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McAleer, M |
Advances in Decision Sciences |
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Macroeconomic Policy to Aid Recovery after Social Distancing for COVID-19 |
McDonald, IM |
Australian Economic Review |
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McDowall, RD |
LC-GC North America |
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McGreal, R |
Canadian Journal of Learning and Technology |
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McKinney, EL, McKinney, et al |
African Journal of Disability |
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Mehta, S, Dooley, et al |
American Journal of Medical Quality |
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Rapidly organize redeployed medical staff in coronavirus disease 2019 pandemic:
what we should do |
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Chin Med J (Engl) |
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Mercuri, V, D'Amico, et al |
J Endocrinol Invest |
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Merodio, G, Ramis-Salas, et al |
Sustainability (Switzerland) |
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Four health science librarians’ experiences how they responded to the covid-19 pandemic
crisis |
Mi, M, Zhang, et al |
College and Research Libraries News |
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Critically ill patients with COVID-19: are they hemodynamically unstable and do
we know why? |
Michard, F, Vieillard-Baron, et al |
Intensive care medicine |
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5M's and More: A New Geriatric Medical Student Virtual Curriculum during the COVID-19 Pandemic |
Michener, A, Fessler, et al |
J Am Geriatr Soc |
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COVID-19 and Emergency care for adults experiencing homelessness |
Miller, JP, Phillips, et al |
Emerg Med Australas |
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Misra, A, Diabetes, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
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32918431; Covid-19 – how prepared are emergency departments in embracing the new
norm? |
Mohamad, MIBK, Ahmad, et al |
Medical Journal of Malaysia |
Commentary/Editorial| Commentaire/Éditorial |
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32921737; International Efforts to Save Healthcare Personnel during COVID-19 |
Mohamed, K, Rezaei, et al |
Acta bio-medica : Atenei Parmensis |
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Worldwide asthma societies’ recommendations
during the covid-19 pandemic |
Mohamedsaeed, M, Sanneerappa, et al |
Irish medical journal |
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Mokhtari, H, Mirzaei, et al |
Public health |
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Montano Luna, JA, Díaz, et al |
Revista Habanera de Ciencias Medicas |
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Moon, J, Moon, et al |
Rural and remote health |
Commentary/Editorial| Commentaire/Éditorial |
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Moreno-Serna, J, Purcell, et al |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Stroke care during the COVID-19 pandemic; a global challenge |
Mowla, A |
Iranian Journal of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Moya, M, Willis, et al |
Revista de Psicologia Social |
Commentary/Editorial| Commentaire/Éditorial |
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32902396; New Zealand's COVID-19 Elimination Strategy - Is it Working? |
Murdoch, DR |
Laeknabladid |
Commentary/Editorial| Commentaire/Éditorial |
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Murphy, JFA |
Irish medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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Murray, G, Gottlieb, et al |
Canadian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7334966; COVID-19 outbreak controls: Lesson learned from Islam |
Musa, HH, Musa, et al |
Ethics Med Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Mask induced psoriasis lesions as Köebner phenomenon during COVID 19 pandemic |
Mutalik, SD, Inamadar, et al |
Dermatol Ther |
Commentary/Editorial| Commentaire/Éditorial |
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32898910; COVID-19 and Maternal Death in Brazil: An Invisible Tragedy |
Nakamura-Pereira, M, Amorim, et al |
Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia |
Commentary/Editorial| Commentaire/Éditorial |
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During
a viral pandemic, anxiety is endemic: The psychiatric aspects of COVID-19 |
Nasrallah, HA |
Current Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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National Academies of Sciences, Engineering, Medicine |
Rapid Expert Consultation on Staffing Considerations for Crisis Standards of Care for the COVID-19 Pandemic (July 28, 2020) |
Commentary/Editorial| Commentaire/Éditorial |
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Cellular senescence as a potential mediator of COVID-19 severity in the elderly |
Nehme, J, Borghesan, et al |
Aging Cell |
Commentary/Editorial| Commentaire/Éditorial |
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Consensus statement regarding minimally invasive surgery during the COVID-19
pandemic |
Nel, D, Oodit, et al |
South African Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Nguyen, MH, Gruber, et al |
Social Media and Society |
Commentary/Editorial| Commentaire/Éditorial |
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Nierenberg, AA |
Psychiatric Annals |
Commentary/Editorial| Commentaire/Éditorial |
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Telepsychiatry in the time of COVID-19: Shattering assumptions |
Nierenberg, AA, Hackett, et al |
Psychiatric Annals |
Commentary/Editorial| Commentaire/Éditorial |
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Nijman, RG, De Guchtenaere, et al |
Frontiers in Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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Nimmo, A, Skinner, et al |
BMJ Case Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus
pandemic-medical law and ethical issues in the United States |
Noguchi, T, Wilbur, et al |
Medicine and law |
Commentary/Editorial| Commentaire/Éditorial |
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Dyspneic and non-dyspneic (silent) hypoxemia in COVID-19: Possible neurological
mechanism |
Nouri-Vaskeh, M, Sharifi, et al |
Clinical neurology and neurosurgery |
Commentary/Editorial| Commentaire/Éditorial |
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Ntounis, N, Mumford, et al |
Saf Sci |
Commentary/Editorial| Commentaire/Éditorial |
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When all doors close: Implications of COVID-19 for cosmopolitan entrepreneurs |
Nummela, N, Paavilainen-Mäntymäki, et al |
International Small Business Journal: Researching Entrepreneurship |
Commentary/Editorial| Commentaire/Éditorial |
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O’connor, C, O’connell, et al |
Irish medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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Compliance with immunosuppression
for rheumatic disease during the COVID-19 pandemic |
O’leary, A, Urbaniak, et al |
Irish medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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Pulmonary
rehabilitation programme: A transcendence during COVID-19 pandemic |
O’reilly, M, Gillen, et al |
Irish medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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32921733; Vaccine hesitancy in COVID-19 times. An update from Italy before flu season
starts |
Odone, A, Bucci, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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32903225; COVID-19 Sustainable lockdown exit plan - the Nigerian Model |
Odumosu, BT, Suleiman, et al |
Journal of infection in developing countries |
Commentary/Editorial| Commentaire/Éditorial |
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Ohta, R, Ryu, et al |
Rural and remote health |
Commentary/Editorial| Commentaire/Éditorial |
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) |
O'Leary, VB, Ovsepian, et al |
Trends in Genetics |
Commentary/Editorial| Commentaire/Éditorial |
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Web-based standardized patient encounters for preclinical dental students during COVID-19
pandemic |
Omar, H, Archer, et al |
Journal of dental education |
Commentary/Editorial| Commentaire/Éditorial |
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Health workers as hate crimes targets during COVID-19 outbreak in the Americas |
Orellana, CI |
Revista de Salud Publica |
Commentary/Editorial| Commentaire/Éditorial |
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Metric analysis of the scientific production about COVID-19 in scopus |
Ortiz-Núñez, R |
Revista Cubana de Informacion en Ciencias de la Salud |
Commentary/Editorial| Commentaire/Éditorial |
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Osadchuk, MA, Trushin, et al |
Journal of Advanced Research in Law and Economics |
Commentary/Editorial| Commentaire/Éditorial |
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32913283; The global response to the COVID-19 pandemic: how have immunology societies
contributed? |
Osier, F, Ting, et al |
Nature Reviews Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Prophylactic anticoagulation of individuals with Proteus syndrome and COVID-19 |
Ours, CA, Biesecker, et al |
American Journal of Medical Genetics, Part A |
Commentary/Editorial| Commentaire/Éditorial |
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Oyeniran, OI, Chia, et al |
Ethics Med Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Pagano, E, Castiglione, et al |
Recenti progressi in medicina |
Commentary/Editorial| Commentaire/Éditorial |
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Pajarianto, H, Galugu, et al |
International Journal of Psychosocial Rehabilitation |
Commentary/Editorial| Commentaire/Éditorial |
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What Would Jenner and Pasteur Have Done About COVID-19 Coronavirus? The Urges of
a Vaccinologist |
Palatnik-de-Sousa, CB |
Frontiers in Immunology |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7373053; COVID-19 and hydroxychloroquine: Let the available data speak for themselves |
Paliani, U, Cardona, et al |
Eur J Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Papatzikis, E, Zeba, et al |
Frontiers in Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Park, J, Park, et al |
Korean journal of medical education |
Commentary/Editorial| Commentaire/Éditorial |
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Parrill, A, Tsao, et al |
Journal of Microbiology, Immunology and Infection |
Commentary/Editorial| Commentaire/Éditorial |
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Light and shadows of the new therapies for haemophilia treatment in the COVID-19 era |
Pasca, S, Zanon, et al |
Blood Transfus |
Commentary/Editorial| Commentaire/Éditorial |
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Bibliometric analysis of latin american and caribbean scientific production about
COVID-19 in pubmed |
Pascual, CT, Torrell-Vallespín, et al |
Revista Cubana de Informacion en Ciencias de la Salud |
Commentary/Editorial| Commentaire/Éditorial |
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Pastor, LM |
Cuadernos de bioetica : revista oficial de la Asociacion Espanola de Bioetica y Etica Medica |
Commentary/Editorial| Commentaire/Éditorial |
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Patel, SK, Pathak, et al |
Le infezioni in medicina |
Commentary/Editorial| Commentaire/Éditorial |
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Invited editorial: Despite COVID-19, influenza must not be relegated to “only the
sniffles” |
Pawelec, G |
Vaccines |
Commentary/Editorial| Commentaire/Éditorial |
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Pecho-Silva, S, Navarro-Solsol, et al |
Revista Cubana de Investigaciones Biomedicas |
Commentary/Editorial| Commentaire/Éditorial |
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Peiris, Malik, Leung, et al |
The Lancet |
Commentary/Editorial| Commentaire/Éditorial |
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32921709; Future psychiatric services in Italy: lesson from the COVID-19 pandemic |
Pelizza, L, Pupo, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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The Cost of Coronavirus Uncertainty: The High Returns to Clear Policy Plans |
Pellegrino, G, Ravenna, et al |
Australian Economic Review |
Commentary/Editorial| Commentaire/Éditorial |
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Peng, J, Wu, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Safe sleep apnea tests during Covid-19 pandemic: a new practical proposal |
Perger, E, Trentin, et al |
Sleep medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Persico, AL, Kwon, et al |
Pharmacy times |
Commentary/Editorial| Commentaire/Éditorial |
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Petridou, E, Zahariadis, et al |
European Policy Analysis |
Commentary/Editorial| Commentaire/Éditorial |
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Piñar-Navarro, E, Fuente, et al |
Emergencias |
Commentary/Editorial| Commentaire/Éditorial |
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Poggiali, E, Vercelli, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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Polo, D, Quintela-Baluja, et al |
Water research |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of an Improvised System on Preserving Oxygen Supplies in Patients With
COVID-19 |
Poncin, W, Baudet, et al |
Archivos de Bronconeumologia |
Commentary/Editorial| Commentaire/Éditorial |
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Training manual for prevention of Covid-19 disease among hospital personnel |
Poormohammadi, A, Azarian, et al |
Journal of Education and Community Health |
Commentary/Editorial| Commentaire/Éditorial |
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32921741; Treatments for COVID-19: emerging drugs against the coronavirus - reply |
Potì, F |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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Prabhakaran, D, Perel, et al |
Global Heart |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: Current status, Challenges and Future Perspectives |
Prasad, R |
Indian Journal of Clinical Biochemistry |
Commentary/Editorial| Commentaire/Éditorial |
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The Impact of COVID-19 in Brazil: Labour Market and Social Protection Responses |
Prates, I, Barbosa, et al |
Indian Journal of Labour Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Przekwas, A, Chen, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Anesthesiologist age and workforce geography during the United States COVID-19
pandemic |
Quereshy, AU, Quereshy, et al |
Journal of clinical anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Analyzing the effects of COVID-19 pandemic on the financial performance of Chinese listed
companies |
Rababah, A, Al-Haddad, et al |
Journal of Public Affairs |
Commentary/Editorial| Commentaire/Éditorial |
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Fear and trembling of cruise ship employees: Psychological effects of the COVID-19
pandemic |
Radic, A, Lück, et al |
International Journal of Environmental Research and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Rao, P, Friedman, et al |
Resuscitation |
Commentary/Editorial| Commentaire/Éditorial |
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Real-time webrtc-based application for psychological support during COVID-19 |
Rashid, NAM, Buja, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Commentary/Editorial| Commentaire/Éditorial |
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Rausch, JW, Capoferri, et al |
Proc Natl Acad Sci U S A |
Commentary/Editorial| Commentaire/Éditorial |
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Razonable, RR, Marshall, et al |
Mayo Clinic proceedings |
Commentary/Editorial| Commentaire/Éditorial |
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Redondo-Urda, M, Rodríguez-Peguero, et al |
Rev Neurol |
Commentary/Editorial| Commentaire/Éditorial |
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Renigier-Biłozor, M, Źróbek, et al |
Land Use Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Renzaho, AMN |
Risk Anal |
Commentary/Editorial| Commentaire/Éditorial |
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In the epicenter of the epidemic: A look at COVID-19 in Italy |
Riboli, E, Arthur, et al |
Cogitare Enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
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Richardson, L, Crawford, et al |
Cmaj |
Commentary/Editorial| Commentaire/Éditorial |
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Ridley, EJ, Freeman-Sanderson, et al |
Australian Critical Care |
Commentary/Editorial| Commentaire/Éditorial |
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Ridolfi, R |
New Medit |
Commentary/Editorial| Commentaire/Éditorial |
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Riva, G, Mantovani, et al |
Cyberpsychology, behavior and social networking |
Commentary/Editorial| Commentaire/Éditorial |
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Riva, G, Riva, et al |
Cyberpsychology, behavior and social networking |
Commentary/Editorial| Commentaire/Éditorial |
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Reinforcing the Team: A Call to Critical Care Nephrology in the COVID-19 Epidemic |
Rizo-Topete, L, Husain-Syed, et al |
Blood Purif |
Commentary/Editorial| Commentaire/Éditorial |
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Rodriguez, C, Morris, et al |
Pediatric annals |
Commentary/Editorial| Commentaire/Éditorial |
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Bringing drug production home: how the US is rebuilding the drug supply chain after covid-19 |
Roehr, B |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Roosens, E, De Fruyt, et al |
Tijdschrift voor psychiatrie |
Commentary/Editorial| Commentaire/Éditorial |
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32905696; Audio Interview: Guidelines for Covid-19 Vaccine Deployment |
Rubin, EJ, Baden, et al |
The New England journal of medicine |
Commentary/Editorial| Commentaire/Éditorial |
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32898410; Orchestrating a virtual conference amidst the COVID-19 pandemic |
Rundle, CW, Husayn, et al |
Dermatology online journal |
Commentary/Editorial| Commentaire/Éditorial |
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Salama, HA, Jazieh, et al |
Clinical Lymphoma, Myeloma and Leukemia |
Commentary/Editorial| Commentaire/Éditorial |
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Salcedo, FXR |
Journal for the Study of Religions and Ideologies |
Commentary/Editorial| Commentaire/Éditorial |
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Samah, KAFA, Sani, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Commentary/Editorial| Commentaire/Éditorial |
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Development and prospects of the fintech industry in the context of COVID-19 |
Sambetbayeva, A, Kuatbayeva, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Sánchez Díaz, I, López Barreda, et al |
Asia-Pacific Journal of Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Saniasiaya, J |
Ear Nose Throat J |
Commentary/Editorial| Commentaire/Éditorial |
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Satiani, B, Zigrang, et al |
J Vasc Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Sberna, G, Capobianchi, et al |
Journal of Clinical Virology |
Commentary/Editorial| Commentaire/Éditorial |
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32812788; World Sepsis Day: a global agenda to target a leading cause of morbidity
and mortality |
Schlapbach, LJ, Kissoon, et al |
American journal of physiology.Lung cellular and molecular physiology |
Commentary/Editorial| Commentaire/Éditorial |
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Perspective from a teaching and learning center during emergency remote teaching |
Schlesselman, LS |
American Journal of Pharmaceutical Education |
Commentary/Editorial| Commentaire/Éditorial |
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[Personal health data in times of a pandemic-legal and ethical aspects] |
Schmidhuber, M, Stöger, et al |
Wien Med Wochenschr |
Commentary/Editorial| Commentaire/Éditorial |
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Scott, BI, Fenelon Junior, et al |
Air and Space Law |
Commentary/Editorial| Commentaire/Éditorial |
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Addressing health inequities re-illuminated by the COVID-19 pandemic: How can nursing respond? |
Scott, J, Johnson, et al |
Nurs Forum |
Commentary/Editorial| Commentaire/Éditorial |
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Sen, MK, Gupta, et al |
Le infezioni in medicina |
Commentary/Editorial| Commentaire/Éditorial |
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Fighting the COVID-19 pandemic: Onsite mass workplace testing for COVID-19 in the
Republic of Korea |
Seo, E, Mun, et al |
Annals of Occupational and Environmental Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Seshiah, V, Balaji, et al |
International Journal of Diabetes in Developing Countries |
Commentary/Editorial| Commentaire/Éditorial |
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Sha, Y |
Medicine and law |
Commentary/Editorial| Commentaire/Éditorial |
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Heterogeneous COVID-19 Incidences in Diamond Princess cruise ship: Some
Volatile Informatics |
Shanmugam, Ramalingam |
Research Square prepub |
Commentary/Editorial| Commentaire/Éditorial |
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Sharami, SRY, Yousefnezhad, et al |
Pakistan Journal of Medical and Health Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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32908261; How the FDA should protect its integrity from politics |
Sharfstein, J |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Public health implications of a delay differential equation model for COVID 19 |
Sharma, MM, Shayak, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Sharma, P, Jamwal, et al |
JK Science |
Commentary/Editorial| Commentaire/Éditorial |
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Sheffler, JL, Joiner, et al |
Gerontologist |
Commentary/Editorial| Commentaire/Éditorial |
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Healthcare system approach to managing COVID-19 in a metropolitan community in
Kentucky |
Shields, LBE, Hester, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Shilatifard, A |
Science Advances |
Commentary/Editorial| Commentaire/Éditorial |
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32921719; Implications of Telemedicine in Oncology during the COVID-19 Pandemic |
Shirke, MM, Shaikh, et al |
Acta bio-medica : Atenei Parmensis |
Commentary/Editorial| Commentaire/Éditorial |
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32920345; Perioperative management of COVID 19 patients undergoing coronary
artery bypass surgery |
Shoman, B, Omar, et al |
Journal of clinical anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Sidorov, PI |
Ekologiya Cheloveka (Human Ecology) |
Commentary/Editorial| Commentaire/Éditorial |
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Silva, DS |
Aust N Z J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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New coronoviral infection and other respiratory-viral diseases in pregnant
women: Clinical lecture |
Sinchikhin, SP, Stepanyan, et al |
Gynecology |
Commentary/Editorial| Commentaire/Éditorial |
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Singer, Mervyn, Shipley, et al |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Singh, G, Brodie, et al |
Journal of Thoracic and Cardiovascular Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Delayed access and uptake of care for children
during COVID-19 |
Sloane, C, Mallett, et al |
Irish medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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Smith, P, Bilello, et al |
AJNR.American journal of neuroradiology |
Commentary/Editorial| Commentaire/Éditorial |
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Soffin, EM, Reisener, et al |
HSS Journal |
Commentary/Editorial| Commentaire/Éditorial |
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An edible vaccine development for coronavirus disease 2019: The concept |
Sohrab, SS |
Clinical and Experimental Vaccine Research |
Commentary/Editorial| Commentaire/Éditorial |
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Soliman, S |
Pharmacy times |
Commentary/Editorial| Commentaire/Éditorial |
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32902219; Estimated Blood Glucose and Hemoglobin A1C in COVID-19: a Preliminary
Summarization |
Sookaromdee, P, Wiwanitkit, et al |
Clinical laboratory |
Commentary/Editorial| Commentaire/Éditorial |
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SoRelle, JA, Patel, et al |
Clin Chem |
Commentary/Editorial| Commentaire/Éditorial |
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Sorooshian, S |
J Korean Med Sci |
Commentary/Editorial| Commentaire/Éditorial |
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Standardized 25-Hydroxyvitamin D Measurements in Parkinson's Disease Patients With COVID-19 |
Speeckaert, MM, Speeckaert, et al |
Movement Disorders |
Commentary/Editorial| Commentaire/Éditorial |
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Understanding and Adapting to Leadership Challenges: Navigating the COVID-19 Crisis in
the Bronx |
Spivack, LB, Spivack, et al |
Am J Crit Care |
Commentary/Editorial| Commentaire/Éditorial |
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Staats, PS, Levy, et al |
Neuromodulation |
Commentary/Editorial| Commentaire/Éditorial |
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Stefoudi, D |
Air and Space Law |
Commentary/Editorial| Commentaire/Éditorial |
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32915937; New insights into the dermatology residency application process amid the COVID-19
pandemic |
Stewart, CR, Chernoff, et al |
Cutis |
Commentary/Editorial| Commentaire/Éditorial |
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A Perspective on the Educational "SWOTh" of the Coronavirus Pandemic |
Stoller, JK |
Chest |
Commentary/Editorial| Commentaire/Éditorial |
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Strous, RD, Karni, et al |
J Med Ethics |
Commentary/Editorial| Commentaire/Éditorial |
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Identifying Disparities in the COVID-19 Pandemic: The Quest for Data |
Struthers, SA, Sanghavi, et al |
Kidney Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Whatever it takes? The global financial safety net, Covid-19, and developing
countries |
Stubbs, T, Kring, et al |
World Development |
Commentary/Editorial| Commentaire/Éditorial |
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Su, R, Shen, et al |
Journal of Chinese Political Science |
Commentary/Editorial| Commentaire/Éditorial |
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Su, Y, Tu, et al |
J Infect |
Commentary/Editorial| Commentaire/Éditorial |
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Sujadi, E, Fadhli, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Sukkar, SG, Bassetti, et al |
Nutrition |
Commentary/Editorial| Commentaire/Éditorial |
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Sule, A |
Economic and Political Weekly |
Commentary/Editorial| Commentaire/Éditorial |
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Sunkari, ED, Korboe, et al |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
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Tabish, HB, Basch, et al |
Infection, Disease and Health |
Commentary/Editorial| Commentaire/Éditorial |
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Tabish, TA, Hamblin, et al |
Nano Today |
Commentary/Editorial| Commentaire/Éditorial |
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Takemori, N, Ooi, et al |
ecancermedicalscience |
Commentary/Editorial| Commentaire/Éditorial |
|
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Covid-19: An accidental
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Tang, B, Zhou, et al |
British Columbia Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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32918432; Let us not forget the children of front liners in covid-19 |
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32913041; Covid-19: US should end Gilead's monopoly on producing remdesivir, report says |
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Commentary/Editorial| Commentaire/Éditorial |
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Commentary/Editorial| Commentaire/Éditorial |
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Neurology |
Commentary/Editorial| Commentaire/Éditorial |
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32897791; Forged By AIDS, Storied NYC Residence Boosts Aging In Place |
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Commentary/Editorial| Commentaire/Éditorial |
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32912397; Responding to COVID-19: adjusting TB services in a low-burden setting |
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The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and
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Commentary/Editorial| Commentaire/Éditorial |
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Weil, A |
Health affairs (Project Hope) |
Commentary/Editorial| Commentaire/Éditorial |
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Weiss, DanielJ, Bertozzi-Villa, et al |
The Lancet Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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32534951; The mental health impact of providing spine care during COVID-19 |
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Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Act now to avoid second lockdown, says Independent SAGE |
Wise, J |
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Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Experts divide into two camps of action-shielding versus blanket policies |
Wise, J |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Wise, J |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Witkowska, D |
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Agriculture (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Wright, RC, Partovi, et al |
Clin Transplant |
Commentary/Editorial| Commentaire/Éditorial |
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Wu, G, Woodruff, et al |
The European respiratory journal |
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The effects of exercise on COVID-19 therapeutics: A protocol for systematic review
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Journal of Orthopaedic Science |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans e.g.
WHO publication list and activities by collaborators. Members of the Emerging Sciences group develop 1 -2 point summaries of each publication. Please email Lisa Waddell for additional information:
Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability
to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely to influence future results.
Epidemiology:
the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro, attack rates, case number doubling time, case fatality
rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host
to an uninfected host via direct or indirect routes.
Clinical data
of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well as clinical profiles of patients; presenting symptoms, symptoms over
course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and
interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed, number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic
analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics:
Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research:
Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities:
These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response:
This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment preparation/ stock piling supplies; Education
and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature:
All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial:
For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, e.g.
la liste des publications de l'OMS,
et à des activités des collaborateurs. Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction :
La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats. Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro),
les taux d'attaque, le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que les profils
cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance
de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé. Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes
guéries. *
Coronavirologie : Toutes les recherches relatives
au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes :
Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes, etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la
vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Modèle animal:
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial :
Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des
commentaires.
journaux
Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives