Subject: Daily Scan of COVID-19 Scientific Publications / survol journalier des publications scientifiques du COVID-19,
2020-09-21
Good afternoon,
There are 1334 citations in today’s scan. 62 were considered primary research or review literature.
Highlights today include:
CANADA
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Fallon et al
developed an online checklist-style tool to guide and support work with families during the COVID-19 pandemic informed by an understanding of economic hardship. The tool's development and implementation occurred through an academic/child welfare sector
partnership involving child welfare agencies representing diverse regions and populations in Ontario, Canada. The final version of the clinical tool is a succinct checklist of 12 questions and associated resources that workers can use when assessing families’
needs during the COVID-19 pandemic.
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Cohen-McFarlane et al
create the Novel Coronavirus (2019) Cough Database: NoCoCoDa. NoCoCoDa contains COVID-19 cough events obtained through public media interviews with COVID-19 patients, with the intent of creating unobtrusive remote monitoring tool for medical professionals
that may aid in diagnosis, monitoring and contact tracing which could lead to more efficient and accurate treatments.
TRANSMISSION
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Lopez et al., investigate 12 children who acquired COVID-19 in child care
facilities. The infected children exposed at these three facilities had mild to no symptoms. Detailed contact tracing data show that children can play a role in transmission from child care settings to household contacts.
IPAC
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Frank et al
evaluate the in vitro efficacy of povidone-iodine (PVP-I) nasal antiseptic for the inactivation of SARS-CoV-2. PVP-I nasal antiseptic solutions at concentrations as low as 0.5% rapidly inactivate SARS-CoV-2 at contact times as short as 15 seconds. Intranasal
use of PVP-I has demonstrated safety at concentrations of 1.25% and below and may play an adjunctive role in mitigating viral transmission beyond personal protective equipment. Authors suggest that widespread use of PVP-I nasal antiseptic in patients prior
to intranasal procedures could significantly decrease risk of virus transmission via droplet and aerosol spread.
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Meyers et al
find that a 1% baby shampoo nasal rinse solution inactivated HCoV greater than 99.9% with a 2 min contact time. Several over-the-counter mouthwash/gargle products including Listerine and Listerine-like products were highly effective at inactivating infectious
virus with greater than 99.9% even with a 30 sec contact time.
EPIDEMIOLOGY
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Radujkovic A et al in a pre-print analysis of 185 patients with COVID-19
report that Vitamin D deficiency, as measured at first presentation (serum total 25-hydroxyvitamin D level < 12 ng/mL (<30 nM)) was associated with severity (requiring invasive mechanical ventilation) and mortality of COVID-19 when controlling for age, gender
and comorbidities.
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Swann et al. report on severe SARS-CoV-2 in children and young adults in the UK (ISARIC study) across 260 hospitals Jan 17- Jul 3. 18% (116/632) of children were admitted to critical
care. On multivariable analysis, this was associated with age under 1 month (odds ratio 3.21, 95% confidence interval 1.36 to 7.66; P=0.008), age 10-14 years (3.23, 1.55 to 6.99; P=0.002), and black ethnicity (2.82, 1.41 to 5.57; P=0.003). Children with MIS-C
were more likely to be older, non-white ethnicity, admitted to critical care. No deaths occurred in the MIS-C group
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Lee et al.
studied two unrelated patients with immune thrombocytopenia and autoimmune hemolytic anemia in the setting of COVID-19. The authors found that heterozygous loss-of-function suppressor of cytokine signaling 1 (SOCS1) mutations are associated with enhanced
IFN signalling and increased immune cell activation, thereby predisposing to infection-associated autoimmune cytopenias.
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Abenza-Abildúa
et al., studied neurological complications in SARS-CoV-2 patients admitted in ICU. Severe COVID-19 mainly affected men is associated with old age. 50% of the patients presented acute myopathy,
and over 90% of the patients left the ICU with acute confusional syndrome.
DIAGNOSTICS
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Prazuck et al. conducted a prospective observational study to evaluate the performance of two POC tests, COVID-PRESTO and
COVID-DUO, compared to the gold standard, RT-PCR (real-time reverse transcriptase polymerase chain reaction). COVID-PRESTO and DUO POC tests turned out to be very specific (none false positive) and to be sensitive enough after 15 days from onset of symptom.
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Hirotsu, et al.
assess the performance of the LUMIPULSE antigen test compared to RT-qPCR. The antigen level was significantly higher in PCR-positive samples than in negative samples. In specimens with > 100 viral copies and between 10 and 100 copies, the antigen test
showed 100% and 85% concordance with RT-qPCR, respectively. This concordance declined with lower viral loads. In the serially followed patients, the antigen levels showed a steady decline, along with viral clearance.
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Ong et al
assessed the diagnostic performance of the GeneFinderTMCOVID-19 Plus RealAmp Kit on the ELITe InGenius sample-to-result platform (a commercial NAT) targeting genes of SARS-CoV-2. Patients were eligible between March 18 and May 27, 2020, when they had
respiratory symptoms that were suspected for COVID-19. The InGenius platform was compared to routine in-house NAT that was validated according to the national reference. Results indicated that the InGenius platform for SARS-CoV-2 detection has excellent sensitivity,
is easy to use and provides fast results. The inclusion of the N gene as a third gene target may further increase sensitivity for the diagnosis of COVID-19 in comparison to the national reference method.
VACCINE RESEARCH
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Özdemir et al.
tested 42 coumarin derivatives containing 14 different substituents, which are secondary metabolites of plants, and the anticoagulant Coumadin (warfarin) drug as a reference by molecular docking calculation
technique on 6LU7 main protease of the coronavirus. The coumarins data reported in this study serves as a stepping stone for in vitro and in vivo experimental research for vaccine development purposes
THERAPEUTICS
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Edalatifard et al
conducted a single-blind, randomised, controlled, clinical trial of methylprednisolone involving severe hospitalised patients with confirmed COVID-19 in Iran. Patients with clinical improvement were higher in the methylprednisolone group than in the
standard care group (94·1% versus 57·1%), and the mortality rate was numerically lower in the methylprednisolone group (5·9% versus 42.9%; p <0·001).
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Mei-Hong et al., aimed to evaluate the clinical efficacy and safety of hydroxychloroquine sulfate
combined with azithromycin in the treatment of 11 refractory common coronavirus disease 2019 (COVID-19) patients who were admitted to Guanggu Branch of Maternity and Child Healthcare Hospital of Hubei Province from Mar. 22 to 25, 2020. The patients all received
combined treatment regimens: hydroxychloroquine sulfate orally 200 mg three times daily for 7 days; and azithromycin orally 500 mg once daily on day 1 and then 250 mg once daily from day 2 to day 4. The average course of disease of 11 patients before combined
administration was 50.2 days. The treatment process was uneventful. Zero case of SARS-CoV-2 nucleic acid test result turned negative on day 4 after administration, two cases on day 5, two cases on day 6, two cases on day 7, one case on day 8 and one case on
day 9. No patients progressed to severe or critical illness, and no severe side effects were found.
PUBLIC HEALTH REPONSE
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Berman et al sought to explore associations related to COVID-19 discriminatory attitudes and COVID-19 xenophobic attitudes among a sample
within an established cohort of predominately Black sexual minority men living with HIV. Results indicated that choosing to socially distance to reduce COVID-19 exposure was associated with COVID-19 discriminatory attitudes, concerns of contracting COVID-19,
and identifying as transgender. Likewise, social distancing imposed by others (e.g., cancelations and restrictions) was associated with concerns of contracting COVID-19. These potentially negative psychosocial attitudes toward people perceived to have COVID-19
echo the discriminatory actions and attitudes that we continue to observe in HIV social sciences research.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Christina Bancej, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin
Young, Chatura Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Alex Gilbert, Jessie Varga, Vanessa Zubach, Meenu Sharma
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
32762799; Essential Healthcare Services in the Face of COVID-19 Prevention: Experiences from a Referral Hospital in Ethiopia |
Abdela, SG, Berhanu, et al |
The American Journal of Tropical Medicine and Hygiene |
Healthcare Response | Réponse des soins de santé |
Globally, healthcare systems are facing the enormous challenge of the COVID-19 pandemic. Ethiopia is currently implementing
different preventive measures to interrupt the transmission of SARS-CoV-2. The early effect of these preventive measures on essential healthcare service delivery is unknown. In this study, we looked at the number of essential healthcare visits over 8 weeks,
4 weeks before and 4 weeks after the implementation of preventive measures. During the implementation of these measures, patient flow decreased in all elements of essential healthcare service. The decline was dramatic for family planning (98%), emergency surgery
(77%), and follow-up of chronic surgical conditions (70%). An understanding of the reasons behind the decrease in patient flow is urgently needed to design ways of sustaining essential care. |
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Abdel-Rahman, M |
Information Sciences Letters |
Public Health response| Interventions de santé publique |
In this study, we formulated questions on the attitudes of the academies towards the role of social media sites in forming electronic public opinion and
distributed a questionnaire to 148 faculty members at various colleges. It is shown that Facebook ranked first with a percentage of (43.2%), because the participants find it the easiest way to express and share their opinions with their friends and followers.
Instagram, which is used to know the latest news and share photos, ranked second followed by Snapchat, YouTube, and Twitter. Moreover, they used social media sites three hours a day, which is an indication of their importance. Furthermore, expressing their
feelings towards the crisis of COVID-19 outbreak ranked first with a percentage of (78 %). The most important communication benefits were achieved when the academies used social networking sites to post information on their profiles with precautionary and
preventive measures. |
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Abdollahi, A, Shakoori, et al |
Iran J Pathol |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The study compared nasopharyngeal and oropharyngeal swabs taken by patients and technicians by RT-PCR. The overall percentage of agreement among both nasopharyngeal
and oropharyngeal swabs taken by a lab technician and patients was 76% with a kappa value of 0.49 (P=0.001). It was concluded that swabs should be taken by trained technicians as it impacts laboratory testing. |
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Neurological complications in critical patients with COVID-19 |
Abenza-Abildúa, MJ, Ramírez-Prieto, et al |
Neurologia |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The authors studied neurological complications in SARS-CoV-2 patients admitted in ICU. We conducted a retrospective, observational, descriptive study
of consecutive patients admitted to the ICU due to severe respiratory symptoms secondary to SARS-CoV-2 infection between 1 April and 1 June 2020. Severe COVID-19 mainly affected men and is associated with old age. 50% of the patients presented acute myopathy,
and over 90% of the patients left the ICU with acute confusional syndrome. |
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Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong |
Adam, DC, Wu, et al |
Nat Med |
Epidemiology| Épidémiologie Transmission |
Superspreading events (SSEs) have characterized previous epidemics of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory
syndrome coronavirus (MERS-CoV) infections(1-6). For SARS-CoV-2, the degree to which SSEs are involved in transmission remains unclear, but there is growing evidence that SSEs might be a typical feature of COVID-19(7,8). Using contact tracing data from 1,038
SARS-CoV-2 cases confirmed between 23 January and 28 April 2020 in Hong Kong, we identified and characterized all local clusters of infection. We identified 4-7 SSEs across 51 clusters (n = 309 cases) and estimated that 19% (95% confidence interval, 15-24%)
of cases seeded 80% of all local transmission. Transmission in social settings was associated with more secondary cases than households when controlling for age (P = 0.002). Decreasing the delay between symptom onset and case confirmation did not result in
fewer secondary cases (P = 0.98), although the odds that an individual being quarantined as a contact interrupted transmission was 14.4 (95% CI, 1.9-107.2). Public health authorities should focus on rapidly tracing and quarantining contacts, along with implementing
restrictions targeting social settings to reduce the risk of SSEs and suppress SARS-CoV-2 transmission. |
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Containing COVID-19 through physical distancing: the impact of real-time crowding
information |
Adam, M, Werner, et al |
European Journal of Information Systems |
Public health interventions*| Interventions de santé publique |
With the rise of COVID-19, decision support systems (DSS) increasingly display crowding information (CI) (e.g. how
crowded a medical practice is) to encourage physical distancing when users select locations. Despite important implications for containing COVID-19, little is known about the causal effect of CI on user selection behaviour and how the immediacy of CI (e.g.
“updated 2 minutes ago“) as well as users’ health anxiety further influence the effect of CI. Drawing on literature on digital choice environments and construal level theory, we conducted a multi-national online experiment to investigate the effect of CI on
selecting differently crowded medical practices. Our results demonstrate that present (vs. absent) CI in DSS increases the likelihood of users selecting less crowded medical practices, while the effect is strongest when employed with real-time (vs. historical
average) CI and, surprisingly, when users’ health anxiety is low (vs. high). Overall, our study adds to the growing body of research on IS in the age of pandemics and provides actionable insights for DSS providers and policymakers to endow users with information
to identify and select less crowded locations, thus containing COVID-19 through improved physical distancing without paternalistically restricting users’ freedom of choice. © Operational Research Society 2020. |
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Measuring Food Insecurity during the COVID-19 Pandemic of Spring 2020 |
Ahn, S, Norwood, et al |
Applied Economic Perspectives and Policy |
Public Health response| Interventions de santé publique |
The COVID-19 pandemic in the spring of 2020 resulted high levels of unemployment, higher food prices, and loss of business
sales. This deterioration in households' financial status likely increased food insecurity in the US, but by how much? While the US government will not measure food insecurity until December of 2020, previous research has developed a methodology whereby internet
surveys that can be rapidly deployed using opt-in panels can approximate government numbers. We employ this methodology to measure food insecurity in May of 2020. Results suggest that while there is little to no detectable rise in food insecurity for all households,
the percent of households with children classified as food insecure is about three percentage points higher than it was in 2016 and 2017. © 2020 Agricultural and Applied Economics Association |
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Prolongation of QT interval due to hydroxychloroquine
overdose used in COVID-19 treatment |
Aksel, G, Islam, et al |
Turkish Journal of Emergency Medicine |
Clinical data| Données cliniques |
In this case report, we aimed to present a young patient whose QT interval was prolonged due to hydroxychloroquine
overdose which was given for COVID-19 treatment. The patient was diagnosed with COVID-19 a day prior and home isolation was recommended with hydroxychloroquine and oseltamivir P. O. treatment. His complaints started 6 h after accidentally taking 1.600 mg of
hydroxychloroquine P. O. at the same time. On physical examination, the Glasgow Coma Scale was 15, and neurological, respiratory, and abdominal examinations were normal. His pulse was 54 beats/min, oxygen saturation was 99%, arterial blood pressure was 122/82
mmHg, and fever was 36.5°C. Electrocardiography (ECG) showed sinus bradycardia and corrected QT interval was calculated as 510 ms. The QT interval prolongation and bradycardia persisted, and the patient was hospitalized for follow-up and treatment. Due to
the potential cardiac side effects, patients who are sent to home isolation with treatment should be educated about the use, dosage, and possible side effects of this medicine, and serial ECG monitoring should be provided to patients who are hospitalized. |
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Alamdari, NM, Afaghi, et al |
Tohoku Journal of Experimental Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective study, we aimed to determine the prognostic factors associated with mortality in COVID-19 patients
by analyzing 396 survived and 63 non-survived patients in Shahid Modarres Hospital, Tehran, Iran, from January 30th until April 5th, 2020. The BMI > 35 (p = 0.0003), lung cancer (p = 0.007), chronic kidney disease (p = 0.002), Immunocompromised condition (p
= 0.003), and diabetes (p = 0.018) were more frequently observed in the expired group. The history of statins use was more common in the discharged group (p = 0.002), while there was no significant difference in the drug history of angiotensin-converting enzyme
inhibitors, angiotensin II receptor blockers, nonsteroidal anti-inflammatory drugs, aspirin, and/or steroids, and in the past-year influenza vaccination. Multivariable regression demonstrated rising odds of in-hospital death related with age (odds ratio (OR)
= 1.055, p = 0.002), levels of C-reactive protein (CRP) (OR = 2.915, p < 0.001), creatinine (OR = 1.740, p = 0.023), lymphocyte count (OR = 0.999, p = 0.008), and magnesium level (OR = 0.032, p < 0.001) on admission. In conclusion, the patients with older
age and higher BMI with lymphopenia, hypomagnesemia, elevated CRP and/or raised creatinine on admission are at higher risk of mortality due to the COVID-19 infection, which requires the physicians to use timely and strong therapeutic measures for such patients. |
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The Impact of COVID-19 on Epilepsy Care: A Survey
of the American Epilepsy Society Membership |
Albert, DVF, Das, et al |
Epilepsy Curr |
Public Health response| Interventions de santé publique |
To better study the effect of the pandemic on people with epilepsy (PWE), members of the American Epilepsy Society
were surveyed between April 30 and June 14, 2020. About a third (30%) of respondents stated that they had patients with COVID-19 and reported no significant change in seizure frequency. Conversely, one-third of respondents reported new onset seizures in patients
with COVID-19 who had no prior history of seizures. The majority of respondents felt that there were at least some barriers for PWE in receiving appropriate clinical care, neurophysiologic procedures, and elective surgery. Medication shortages were noted by
approximately 30% of respondents, with no clear pattern in types of medication involved. Telehealth was overwhelmingly found to have value. |
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Alboraie, M, Piscoya, et al |
Arab Journal of Gastroenterology |
Healthcare Response | Réponse des soins de santé |
We aim to report the real-life performance in high volume GI endoscopy units during the pandemic. Participants from
48 countries (n = 163) responded to the survey with response rate of 67.35%. The majority (85%) decreased procedure volume by over 50%, and four endoscopy units (2.45%) completely stopped. The top three indications for procedures included upper GI bleeding
(89.6%), lower GI bleeding (65.6%) and cholangitis (62.6%). The majority (93.9%) triaged patients for COVID-19 prior to procedure. N95 masks were used in (57.1%), isolation gowns in (74.2%) and head covers in (78.5%). Most centers (65%) did not extend use
of N95 masks, however 50.9% of centers reused N95 masks. Almost all (91.4%) centers used standard endoscopic decontamination and most (69%) had no negative pressure rooms. Forty-two centers (25.8%) reported positive cases of SARS-CoV-2 infection among patients
and 50 (30.7%) centers reported positive cases of SARS-CoV-2 infection among their healthcare workers.Most GI endoscopy centers had a significant reduction in their volume and most procedures performed were urgent. Most centers used the recommended personal
protective equipment (PPE) by GI societies however there is still a possibility of transmission of SARS-CoV-2 infection in GI endoscopy units. |
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Heart Transplant Recipients with Confirmed 2019 Novel Coronavirus Infection: The Detroit
Experience |
Al-Darzi, W, Aurora, et al |
Clin Transplant |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Patients with a history of orthotopic heart transplant (OHT) at a tertiary care transplant center in Detroit, Michigan
were retrospectively reviewed from March until May 2020. Clinical parameters and outcomes of 5 OHT recipients and one combined heart-lung recipient with confirmed SARS-CoV-2 were obtained. The most common presenting symptoms were fever and shortness of breath
83% (n=5), followed by cough and chills 67% (n=4). All admitted patients (n=5) received hydroxychloroquine and 3 received high dose steroids. Antimetabolites were held for 2 patients (33.3%). The calcineurin inhibitor trough goal was decreased in only 1 patient;
3 other patients, without change in goal, required calcineurin inhibitor dosage reduction. OHT patients infected by the SARS-CoV-2 virus did not have an elevated risk of severe infection. Impact of modifying immunosuppression remains unclear. |
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Alshammari, E, Alsaleh, et al |
Military Medical Science Letters (Vojenske Zdravotnicke Listy) |
Healthcare Response | Réponse des soins de santé |
The current study sought to examine healthcare workers HCWs awareness and perceptions of coronavirus disease in Kuwait
hospitals. A prospective study design was used to examine the development of the disease among 28 HCWs between mid-May and the start of June 2020. The primary findings were as follows; most
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Ammar, A, Trabelsi, et al |
Biology of Sport |
Public Health response| Interventions de santé publique |
This study aimed to provide scientific data to help identify risk factors for the psychosocial strain during the COVID-19
outbreak. An international cross-disciplinary online survey was circulated in April 2020. This report outlines the mental, emotional and behavioural consequences of COVID-19 home confinement. 1047 replies (54% women) from Western Asia (36%), North Africa
(40%), Europe (21%) and other continents (3%) were analysed. The COVID-19 home confinement evoked a negative effect on mental wellbeing and emotional status (P < 0.001; 0.43 ≤ d ≤ 0.65) with a greater proportion of individuals experiencing psychosocial and
emotional disorders (+10% to +16.5%). These psychosocial tolls were associated with unhealthy lifestyle behaviours with a greater proportion of individuals experiencing (i) physical (+15.2%) and social (+71.2%) inactivity, (ii) poor sleep quality (+12.8%),
(iii) unhealthy diet behaviours (+10%), and (iv) unemployment (6%). Conversely, participants demonstrated a greater use (+15%) of technology during the confinement period. These findings elucidate the risk of psychosocial strain during the COVID-19 home confinement
period and provide a clear remit for the urgent implementation of technology-based intervention to foster an Active and Healthy Confinement Lifestyle AHCL. |
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Anastasopoulos, C, Weikert, et al |
European Journal of Radiology |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
In this study, authors implemented an automated software solution for quantification of pulmonary opacities. Deep convolutional
neural network algorithms for lung segmentation and opacity quantification on chest CTs were trained using semi-automatically and manually created ground-truth (Ntotal = 172). The final algorithm was available at day 10 and achieved human-like performance
(Dice coefficient = 0.97). For opacity quantification, a slight underestimation was seen both for the in-house (1.8 %) and for the external algorithm (0.9 %). In contrast to the external reference, the underestimation for the in-house algorithm showed no dependency
on total opacity load, making it more suitable for follow-up. The algorithm for fully automated lung segmentation and opacity quantification was ready for clinical use within just 10 days and achieved human-level performance even in complex cases. |
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Anderez, DO, Kanjo, et al |
Sensors (Switzerland) |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission
Public health interventions*| Interventions de santé publique |
Long-established compartmental epidemiological models like SIR and SEIR do not account for the variability encountered
in the severity of the SARS-CoV-2 disease across different population groups. The objective of this study is to investigate how a reduction in the exposure of vulnerable individuals to COVID-19 can minimise the number of deaths caused by the disease, using
the UK as a case study. Authors proposed that a modified model, namely SEIR-v, through which the population is separated into two groups regarding their vulnerability to SARS-CoV-2 is applied. The results indicate a large number of deaths could be avoided
by a slight realistic decrease in the exposure of vulnerable groups to the disease. A number of mechanisms are proposed to limit the exposure of vulnerable individuals to the disease. One option could be the provision of a wristband to vulnerable people and
those without a smartphone and contact-tracing app, filling the gap created by systems relying on smartphone apps only. |
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Impact of hvac-systems on the dispersion of infectious aerosols in a cardiac intensive
care unit |
Anghel, L, Popovici, et al |
International Journal of Environmental Research and Public Health |
Transmission Infection Prevention and Control/ Prévention et contrôle des infections
(IPAC/PCI) |
At the end of 2019, a variation of a coronavirus, named SARS-CoV-2, has been identified as being responsible for a
respiratory illness disease (COVID-19). Since ventilation is an important factor that influences airborne transmission, we proposed to study the impact of heating, ventilation and air-conditioning (HVAC) with a variable air volume (VAV) primary air system,
on the dispersion of infectious aerosols, in a cardiac intensive care unit, using a transient simulation with computational fluid dynamics (CFD), based on the finite element method (FEM). We analyzed three scenarios that followed the dispersion of pathogen
carrying expiratory droplets particles from coughing, from patients possibly infected with COVID-19, depending on the location of the patients in the intensive care unit. Our study provides the mechanism for spread of infectious aerosols, and possibly of COVID-19
infection, by air conditioning systems and also highlights important recommendations for disease control and optimization of ventilation in intensive care units, by increasing the use of outdoor air and the rate of air change, decreasing the recirculation
of air and using high-efficiency particulate air (HEPA) filters. The CFD-FEM simulation approach that was applied in our study could also be extended to other targets, such as public transport, theaters, philharmonics and amphitheaters from educational units.
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
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Arbeitman, ClaudiaR, Auge, et al |
bioRxiv |
Coronavirology| Coronavirologie |
The yeast Pichia pastoris is a cost-effective and easily scalable system for recombinant protein production. In this
work we compared the conformation of the receptor binding domain (RBD) from SARS-CoV-2 Spike protein expressed in P. pastoris and in the well established HEK-293T mammalian cell system. RBD obtained from both yeast and mammalian cells was properly folded,
as indicated by UV-absorption, circular dichroism and tryptophan fluorescence. They also had similar stability, as indicated by temperature-induced unfolding (observed Tm were 50 °C and 52 °C for RBD produced in P. pastoris and HEK-293T cells, respectively).
Moreover, the stability of both variants was similarly reduced when the ionic strength was increased, in agreement with a computational analysis predicting that a set of ionic interactions may stabilize RBD structure. Further characterization by HPLC, size-exclusion
chromatography and mass spectrometry revealed a higher heterogeneity of RBD expressed in P. pastoris relative to that produced in HEK-293T cells, which disappeared after enzymatic removal of glycans. The production of RBD in P. pastoris was scaled-up in a
bioreactor, with yields above 45 mg/L of 90% pure protein, thus potentially allowing large scale immunizations to produce neutralizing antibodies, as well as the large scale production of serological tests for SARS-CoV-2.Competing Interest StatementThe authors
have declared no competing interest. |
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COVID-19 Outbreak in Colombia: An Analysis of Its Impacts on Transport Systems |
Arellana, J, Márquez, et al |
Journal of Advanced Transportation |
Public Health response| Interventions de santé publique Economics | Économie |
This paper studies the short-term impacts on the transport system caused by the different policies adopted by the Colombian
government and local authorities to contain the COVID-19 spread. Authors analyzed the impacts on three components of the transport system: air transport, freight transport, and urban transport. Results show that national policies and local decisions have
decreased the demand for motorised trips across the cities, diminishing congestion levels, reducing transit ridership, and creating a reduction in transport externalities. The country banned air transport for passengers and only allowed air cargo for medical
and necessary supplies, which will have negative consequences for the economics of the airline industry. During the first three months of the COVID-19, freight was the most resilient transport component. However, freight trips diminished around 38%, affecting
mainly the supply chain of nonessential products. |
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Arora, S, Saquib, et al |
Journal of Multidisciplinary Healthcare |
Healthcare Response | Réponse des soins de santé |
The present survey was thus conducted to assess the knowledge, risk perception, attitude, and preparedness of the dentists
in India about COVID-19. A self-administered, anonymous, questionnaire comprising of 25 close-ended questions was circulated to gather the relevant information. A total of 765 dentists submitted a response, out of which 646 complete responses were included
in the statistical analysis. Dentists included in the study had presented satisfactory knowledge with adequate preparedness as the majority of them had a fair level of knowledge with significantly higher knowledge among female respondents and those with post-graduation
studies. Dentists should make judicious utilization of all the precautionary measures to safely practice dentistry. |
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Asman, A, Barlian, et al |
Journal of Advanced Research in Dynamical and Control Systems |
Public Health Priorities| Priorités de santé publique Public Health response| Interventions
de santé publique |
Study aims to develop a trauma healing policy model for the community during the COVID-19 pandemic in Padang City.
In compiling a policy model, used stigma or point of view, mental or mental health, and behaviour as policy criteria. The results showed 4 priority policies for consideration for the Padang City government. |
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Atreya, S, Kumar, et al |
Indian Journal of Palliative Care |
Healthcare Response | Réponse des soins de santé |
A exploratory survey was designed to assess the changes in the hospital-based practice of palliative care in the COVID-19
pandemic and patient/caregiver's perception about the provision of telehealth services to palliative care patients of a tertiary care cancer hospital of eastern India. Results: There was a dramatic reduction in the outpatient clinic footfalls by 51% with teleconsultation.
Although there was no change in the number of emergency visits, the inpatient admissions reduced by 44%. Nearly 82% of patient/caregivers gave a positive feedback about telemedicine care provided by the department and mentioned that the service provided them
with support and connectedness. Almost 64% of the patients and caregivers reported that the service helped allay the fear and reassured them that there was a someone to support them. As high as 76% of the participants felt that they would prefer teleconsultation
in future and were ready to pay for teleconsultations if charges were to be applied in the future. |
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Subacute stent thrombosis in a patient with COVID-19 pneumonia |
Ayan, M, Kovelamudi, et al |
Baylor University Medical Center Proceedings |
Clinical data| Données cliniques |
Acute and subacute stent thromboses are rare but life-threatening complications of primary coronary intervention and
stenting. We present a case of a patient with COVID-19 infection who presented with pneumonia, acute respiratory failure, and non–ST elevation myocardial infarction. Reperfusion was achieved with coronary angioplasty and drug-eluting stent placement, and the
patient was started on aspirin and clopidogrel. However, 72 hours later, the patient experienced an episode of subacute stent thrombosis. This raises concerns about a possible association between stent thrombosis and increased thrombogenicity and platelet
aggregability triggered by COVID-19 infection. © Copyright © 2020 Baylor University Medical Center. |
|
Banerjee, R, Roy, et al |
American Journal of Infection Control |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
Authors investigated a unique approach to reuse the mask by creating a hybrid model that efficiently sanitizes the
infected mask; ultraviolet irradiation and heat treatment. Advantages of the proposed hybrid model as compared to the respective single arms is its decontamination efficacy, operational speed, as well as the number of reuse cycles as verified by mathematical
analysis and simulation. This model is mainly intended for medical PPE but can also be used for other domestic and personal sanitization during the COVID-19 pandemic and can be extended to any other infectious agents. |
|
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Barabas, J, Zalman, et al |
|
Public health interventions*| Interventions de santé publique |
Since the beginning of the current COVID-19 pandemic, more than five million people have been infected and the numbers
are still on the rise. Early symptom detection and proper hygienic standards are thus of utmost importance, especially in venues where people are in random or opportunistic contact with each other. To this end, automated systems with medical-grade body temperature
measurement, hygienic compliance evaluation and individualized, person-to-person tracking, are essential, not only for disease spread intervention and prevention, but also to assure economic stability. Herein, we present a system that encapsulates all of the
mentioned functionality via readily-available components (both hardware and software) and is further enhanced with preliminary RTLS data acquisition, enabling post-symptom detected, person-to-person interaction identification to asses potential infection vectors
and mitigate further propagation thereof by means of smart quarantine. © 2020 IEEE. |
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32891435; Guillain-Barré syndrome as the first manifestation of SARS-CoV-2 infection |
Barrachina-Esteve, O, Palau Domínguez, et al |
Neurologia |
Clinical data| Données cliniques |
Article in Spanish. 54-year-old patient presented to the ER with Guillain-Barré syndrome. Initial SARS-CoV-2 tests
were negative by PCR, however the test was repeated 24 hours later and gave a positive result. |
|
Bartella, AK, Halama, et al |
J Craniofac Surg |
Healthcare Response | Réponse des soins de santé Economics | Économie |
Authors evaluated the impact of pandemic measures on daily routines of maxillofacial surgery (MFS), the surgical schedule
during the first 2 weeks after the onset of the curfew (March 2020), and to compare it with the schedule of the same period of time 1 year earlier. The number of surgeries decreased by 45% (n = 163 in 2019 vs n = 89 in 2020), and the duration of the surgeries
decreased from 94.2 minutes to 62.1 minutes. No elective surgeries, such as implantology, aesthetic surgery, or orthognathic surgery, took place. Furthermore, also trauma cases decreased from 9 to 3 cases. Considering all variables, the financial loss can
be calculated as approximately 100,256.50 Euros per week. |
|
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SARS-CoV-2 infection in an advanced Rheumatoid Arthritis patient |
Bazmjoo, A, Aref Bagherzadeh, et al |
Apmis |
Clinical data| Données cliniques |
Here we present a complicated case of SARS-CoV-2 infection in a female RA patient. |
|
32897192; Confinement du personnel d’Ehpad avec les résidents : une solution
contre le Covid-19 ? |
Belmin, J, Um Din, et al |
Geriatrie et psychologie neuropsychiatrie du vieillissement |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
The Coronarovirus disease 2019 (Covid-19) outbreak strongly affected nursing and was responsible for a high mortality
rate. During the pandemic of March-May 2020, 17 French nursing homes organized staff confinement periods with residents 24 hours a day and 7 days a week, to reduce the risk of entry of the SARS-CoV-2 virus into their facilities, in a context where visits to
residents were prohibited. By means of a telephone survey of their directors, we observed that 16 nursing homes (94%) had no cases of COVID-19 among the residents, and that mortality from COVID-19 was very low compared to that recorded at the national level
by Santé publique France (p<10-4). Moreover, the number of cases of Covid-19 among the staff of these nursing homes was also lower than that recorded by Santé publique France (p<10-4). These establishments experienced certain difficulties which the directors
managed to overcome and the investment of these teams was widely appreciated by the families of the residents and through the press. |
|
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion |
Benton, DJ, Wrobel, et al |
Nature |
Coronavirology| Coronavirologie |
SARS-CoV-2 infection is initiated by virus binding to ACE2 cell surface receptors(1-4), followed by fusion of virus
and cell membranes to release the virus genome into the cell. Both receptor binding and membrane fusion activities are mediated by the virus Spike glycoprotein, S(5-7). As with other class I membrane fusion proteins, S is post-translationally cleaved, in this
case by furin, into S1 and S2 components that remain associated following cleavage(8-10). Fusion activation following receptor binding is proposed to involve the exposure of a second proteolytic site (S2'), cleavage of which is required for the fusion peptide
release(11,12). We have investigated the binding of ACE2 to the furin-cleaved form of SARS-CoV-2 S by cryoEM. We classify ten different molecular species including the unbound, closed spike trimer, the fully open ACE2-bound trimer, and dissociated monomeric
S1 bound to ACE2. The ten structures describe ACE2 binding events which destabilise the spike trimer, progressively opening up, and out, the individual S1 components. The opening process reduces S1 contacts and un-shields the trimeric S2 core, priming fusion
activation and dissociation of ACE2-bound S1 monomers. The structures also reveal refolding of an S1 subdomain following ACE2 binding, that disrupts interactions with S2, notably involving Asp614(13-15), leading to destabilisation of the structure of S2 proximal
to the secondary (S2') cleavage site. |
|
Berman, M, Eaton, et al |
Ann Behav Med |
Public Health response| Interventions de santé publique |
Research on discriminatory attitudes and xenophobic attitudes in the context of an emerging infectious disease is limited.
The authors sought to explore associations related to COVID-19 discriminatory attitudes and COVID-19 xenophobic attitudes among a sample within an established cohort of predominately Black sexual minority men living with HIV. Authors conducted a rapid-response,
cross-sectional survey with people living with HIV (N = 149) to assess social distancing practices, COVID-19 discriminatory attitudes, COVID-19 xenophobic attitudes, HIV microaggressions, and concern over contracting COVID-19. Results indicated that choosing
to socially distance to reduce COVID-19 exposure was associated with COVID-19 discriminatory attitudes, concerns of contracting COVID-19, and identifying as transgender. Likewise, social distancing imposed by others (e.g., cancelations and restrictions) was
associated with concerns of contracting COVID-19. |
|
|
Bertini, M, Ferrari, et al |
Europace |
Clinical data| Données cliniques |
Aim: To describe the electrocardiographic features of critical COVID-19 patients.
|
|
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Beshyah, SA, Ibrahim, et al |
Tunisie Medicale |
Healthcare Response | Réponse des soins de santé |
Objective: To describe the new clinical, educative, and research practices of an international sample of doctors.
|
|
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Biswas, S, Adhikari, et al |
Indian Journal of Palliative Care |
Public Health response| Interventions de santé publique |
Objective: This study aims to assess how palliative medicine physicians could follow up on cancer patients and barriers
they faced, discuss their results, and evaluate their treatment response with the help of telemedicine. |
|
|
Biswas, S, Adhikari, et al |
Indian Journal of Palliative Care |
Healthcare Response | Réponse des soins de santé |
Telemedicine is a feasible tool to provide quality end-of-life care (EOLC) to patients. Adding a widely used smartphone-based
application for video calls along with voice calls and text messages made the process more dynamic and convenient. This article describes the experience with three patients with advanced malignancy in providing EOLC during COVID-19 lockdown. A well-planned
study for the utility of this service for a larger cancer patient population from different sociocultural and demographic backgrounds is warranted in the future. |
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SARS-CoV-2-Associated Deaths Among Persons Aged <21 Years - United States,
February 12-July 31, 2020 |
Bixler, D, Miller, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie |
This report describes characteristics of U.S. persons in that population who died in association with SARS-CoV-2 infection,
as reported by public health jurisdictions. Among 121 SARS-CoV-2-associated deaths reported to CDC among persons aged <21 years in the United States during February 12-July 31, 2020, 63% occurred in males, 10% of decedents were aged <1 year, 20% were aged
1-9 years, 70% were aged 10-20 years, 45% were Hispanic persons, 29% were non-Hispanic Black (Black) persons, and 4% were non-Hispanic American Indian or Alaska Native (AI/AN) persons. Among these 121 decedents, 91 (75%) had an underlying medical condition,*
79 (65%) died after admission to a hospital, and 39 (32%) died at home or in the emergency department (ED).(†) These data show that nearly three quarters of SARS-CoV-2-associated deaths among infants, children, adolescents, and young adults have occurred in
persons aged 10-20 years, with a disproportionate percentage among young adults aged 18-20 years and among Hispanics, Blacks, AI/ANs, and persons with underlying medical conditions. Careful monitoring of SARS-CoV-2 infections, deaths, and other severe outcomes
among persons aged <21 years remains particularly important as schools reopen in the United States. |
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32683946; The Impact of Hospital Bed Density on the COVID-19 Case Fatality Rate in
the United States |
Bloom, JA, Foroutanjazi, et al |
American Surgeon |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
Abstract not available. Full text not available open access. |
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32662399; Case Report: Novel Coronavirus-A Potential Cause of
Acute Pancreatitis? |
Bokhari, SMMA, Mahmood, et al |
The American Journal of Tropical Medicine and Hygiene |
Clinical data| Données cliniques |
A 32-year-old medical practitioner presented to the emergency department with complaints of severe abdominal pain,
fever, and vomiting, 1 week after the diagnosis of COVID-19. The patient did not report any comorbid conditions, alcohol usage, or gallstone disease. Laboratory and radiological investigations revealed the diagnosis of acute pancreatitis. He underwent conservative
management and was discharged after 3 days of hospital admission. This case highlights a possible association between COVID-19 and acute pancreatitis, and the need for clinicians to carefully evaluate patients presenting with gastrointestinal complaints during
the current pandemic. |
|
Regional economic impact of COVID-19 in Colombia: An input–output
approach |
Bonet-Morón, J, Ricciulli-Marín, et al |
Regional Science Policy and Practice |
Economics | Économie |
The aim of this paper is to assess the regional economic impact of the lockdown measures ordered by the national government
to prevent the spread of COVID-19. Using an input–output model, we estimate the economic loss of extracting groups of formal and informal workers from different economic sectors. Results show monthly economic losses that represent between 0.5% and 6.1% of
national GDP, depending on the scenario considered. Accommodation and food services, real estate, administrative services, construction and trade are the most affected sectors. Regionally, Antioquia, Boyacá, San Andrés, Santander and Valle del Cauca appear
as highly vulnerable to these restrictions. © 2020 The Author(s). Regional Science Policy and Practice © 2020 RSAI |
|
Booth, A, Omed, et al |
African Journal of Primary Health Care and Family Medicine |
Healthcare Response | Réponse des soins de santé |
This report aims to assesses the efficacy of daily self-screening tools in detecting and managing potential staff cases
of SARS-CoV-2. Our hospital, situated in KwaZulu-Natal, South Africa, developed a daily self-screening tool for all healthcare workers to complete, consisting of questions on symptoms and epidemiological risk factors. The screening tools were collected and
assessed after four weeks of use. Fiftyfour forms were assessed. Twenty-eight (51.9%) forms were not completed, whilst 12 (22.2%) indicated positive symptoms with no documentation that any further medical assessment, testing or isolation was done. We identified
that the poor completion of forms was likely because of the lack of education of staff on the importance of the forms, poor oversight by management, staff forgetfulness or lack of awareness of the forms. Screening of staff is vital during this pandemic but
requires constant oversight by line managers, staff motivation and adequate education. Ongoing development of efficient screening programmes is required. |
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Monocytes and macrophages, targets of SARS-CoV-2: the
clue for Covid-19 immunoparalysis |
Boumaza, Asma, Gay, et al |
bioRxiv |
Clinical data| Données cliniques Immunology | Immunologie |
The objective of this study was to determine if the myeloid compartment was affected in Covid-19 and if monocytes and
macrophages could be infected by SARS-CoV-2. We show here that SARS-CoV-2 efficiently infects monocytes and macrophages without any cytopathic effect. Infection was associated with the secretion of immunoregulatory cytokines (IL-6, IL-10, TGF-b) and the induction
of a macrophagic specific transcriptional program characterized by the upregulation of M2-type molecules. In addition, we found that in vitro macrophage polarization did not account for the permissivity to SARS-CoV-2, since M1- and M2-type macrophages were
similarly infected. Finally, in a cohort of 76 Covid-19 patients ranging from mild to severe clinical expression, all circulating monocyte subsets were decreased, likely related to massive emigration into tissues. Monocytes from Covid-19 patients exhibited
decreased expression of HLA-DR and increased expression of CD163, irrespective of the clinical status. Hence, SARS-CoV-2 drives circulating monocytes and macrophages inducing immunoparalysis of the host for the benefit of Covid-19 disease progression. |
|
Boutin, CA, Grandjean-Lapierre, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Objective: To determine the relative performance of assays developed to detect SARS-CoV-2 RNA in clinical specimens.
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Boyraz, G, Legros, et al |
Journal of anxiety disorders |
Public Health response| Interventions de santé publique |
The purpose of the study was to propose and test two models to understand the relationship between perceived vulnerability
to COVID-19 (PVC) and COVID-19-related traumatic stress (TS), as well as the variables that may mediate and moderate this relationship among individuals who have not yet been infected with COVID-19. Data were collected using an online survey between late March
and early April 2020. Participants were recruited through Amazon Mechanical Turk and included 747 adults living in the United States. Results indicated that both COVID-19-related worries and social isolation were significant mediators of the relationship
between PVC and TS (Model 1). In addition, the results of a moderated mediation analysis indicated that the indirect effect of PVC on TS through COVID-19-related worries was stronger for participants who reported greater social isolation (Model 2). Findings
suggest that both social isolation and disease-related worries may be important variables that can be targeted in interventions to reduce pandemic-related TS. |
|
|
Brahier, T, Meuwly, et al |
Clin Infect Dis |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
BACKGROUND: Point-of-care lung ultrasound (LUS) is a promising pragmatic risk stratification tool in COVID-19. This
study describes and compares LUS characteristics between patients with different clinical outcomes. METHODS: Prospective observational study of PCR-confirmed COVID-19 adults with symptoms of lower respiratory tract infection in the emergency department (ED)
of Lausanne University Hospital. A trained physician recorded LUS images using a standardized protocol. Two experts reviewed images blinded to patient outcome. We describe and compare early LUS findings (acquired within 24hours of presentation to the ED) between
patient groups based on their outcome at 7 days after inclusion: 1) outpatients, 2) hospitalised and 3) intubated/death. Normalized LUS score was used to discriminate between groups. RESULTS: Between March 6 and April 3 2020, we included 80 patients (17 outpatients,
42 hospitalized and 21 intubated/dead). 73 patients (91%) had abnormal LUS (70% outpatients, 95% hospitalised and 100% intubated/death; p=0.003). The proportion of involved zones was lower in outpatients compared with other groups (median 30% IQR 0-40%], 44%
31-70%] and 70% 50-88%], p<0.001). Predominant abnormal patterns were bilateral and multifocal spread thickening of the pleura with pleural line irregularities (70%), confluent B lines (60%) and pathologic B lines (50%). Posterior inferior zones were more
often affected. Median normalized LUS score had a good level of discrimination between outpatients and others with area under the ROC of 0.80 (95% CI 0.68-0.92). CONCLUSIONS: Systematic LUS has potential as a reliable, cheap and easy-to-use triage tool for
the early risk stratification in COVID-19 patients presenting in EDs. |
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|
Busnadiego, I, Fernbach, et al |
mBio |
Coronavirology| Coronavirologie |
This study investigated properties of type I (β), II (γ), and III (λ1) interferons (IFNs), potent immune cytokines
that are normally produced during infection and that upregulate IFN-stimulated gene (ISG) effectors to limit virus replication. Using a cell line model, we found that beta interferon (IFN-β) strongly upregulated expression of ca-nonical antiviral ISGs, as
well as ACE2 at the mRNA and cell surface protein levels. IFN-λ1 upregulated antiviral ISGs, but ACE2 mRNA was only marginally el-evated and did not lead to detectably increased ACE2 protein at the cell surface. IFN-γ induced the weakest ISG response but clearly
enhanced surface expression of ACE2. IFN-γ induced the weakest ISG response but clearly enhanced surface expression of ACE2. Importantly, all IFN types inhibited SARS-CoV-2 replication in a dose-dependent manner, and IFN-β and IFN-λ1 exhibited potent antiviral
activity in primary human bronchial epithelial cells. Our data imply that type-specific mechanisms or kinetics shape IFN-enhanced ACE2 transcript and cell surface levels but that the antiviral action of IFNs against SARS-CoV-2 counterbalances any proviral
effects of ACE2 induction. |
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Volume and Acuity of Emergency Department Visits Prior
To and After COVID-19 |
Butt, AA, Azad, et al |
Journal of Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
Objective: To determine ED volumes and triage acuity prior to and after COVID-19. |
|
Cabero-Martínez, A, Sánchez-Guijo, et al |
Frontiers in Medicine |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
Patients with blood cancers are vulnerable to COVID-19. The Hematology Department developed a protocol to maintain
the Hematology Unit as a “free COVID-19 island.” The protocol included symptom-based surveys and screening tests to patients, caregivers, and healthcare personnel to identify early potential positive cases and prevent its spread. Between March 9 and April
28, 32 asymptomatic patients and caregivers were tested and 68 rT-PCR diagnostic assays have been performed with two positive results. A 106 healthcare workers have been tested (208 rT-PCR) and seven of them were positive. In summary, the implementation of
preemptive measures after the first case appeared allowed us to be able to provide treatment to our patients. |
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Early Psychological Impact of the COVID-19 Pandemic in Brazil: A National Survey |
Campos, Jadb, Martins, et al |
J Clin Med |
Public Health response| Interventions de santé publique |
This study aimed to evaluate the mental health of the Brazilian population during the SARs-CoV-2 pandemic and its relationship
with demographic and health characteristics. High prevalence of depression (61.3%), anxiety (44.2%), stress (50.8%), and psychological impact (54.9%) due to the isolation experienced from the pandemic was found. Younger individuals (OR = 1.58-3.58), those
that felt unsafe (OR = 1.75-2.92), with a previous diagnosis of mental health (OR = 1.72-2.64) and/or had general health problems before the pandemic (OR = 1.17-1.51), who noticed changes in their mental state due to the pandemic context (OR = 2.53-9.07),
and excessively exposed to the news (OR = 1.19-2.18) were at increased risk of developing symptoms. Women (OR = 1.35-1.65) and those with lower economic status (OR = 1.38-2.69) were more likely to develop psychological symptoms. Lower educational levels increased
the likelihood of depressive (OR = 1.03-1.34) and intrusive symptoms (OR = 1.09-1.51). |
|
Cutaneous manifestations in pediatric patients infected with sars-cov-2
coronavirus |
Campos, LG, Pino, et al |
Revista Cubana de Pediatria |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The objective of this study was to characterize pediatric patients with cutaneous manifestations during COVID19 disease.
Ten (n=10) pediatric patients with COVID-19 were admitted to´´Comandante Manuel Piti Fajardo´´ Military Hospital of Villa Clara province. Eight presented eritemato-papular rash and two had urticariform rash. Urticariform lesions were present just in the girls,
the eritomato-papulosa lesions presented similarly in both sexes with slight predominance in female adolescents. Both types of lesions appeared with predominance in the torso and accompanied of slight or absent pruritus. The urticariform lesions required medical
treatment. The main clinical presentations in the pediatric population are the cutaneous manifestations. Eritematopapular lesions are the most frequent; they have late onset and favorable evolution with no need of treatment and with no other symptomatology. |
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Handwashing Behavior of Chinese Population during the COVID-19 Epidemic |
Cao, S, Wei, et al |
Research of Environmental Sciences |
Public Health response| Interventions de santé publique |
This study used an electronic questionnaire to investigate the handwashing behavior and handwashing time of 8330 adults
in 31 provinces in China during February 25th to March 14th, 2020, and the factors affecting hand-washing behavior in different exposure scenarios were then analyzed. The results show that the proportion and duration of hand-washing by women and urban residents
were higher than that of men and rural residents, respectively. People were more likely to wash their hands in general exposure scenarios, while in scenarios with high risk of viral infections, such as after coughing or sneezing and after touching others,
the proportion of handwashing was the lowest, 73.6% and 83.9%, respectively. According to the standards of handwashing time (20 s) stipulated by WHO, 41.7% of the population could reach the qualified level (that is more than 20 s), and the passing rate of
urban residents' handwashing time was significantly higher than that in rural areas (42.0% vs. 39.7%). The handwashing proportion of the people who went out was higher than those who never went out. The passing rate of handwashing time for the residents in
the regions with the most severe epidemic was the lowest (37.2%), while the passing rate of handwashing time for the residents in the regions with the least epidemic was the highest (43.6%). This study indicates that compared with non-epidemic period, the
incidence of handwashing behavior among Chinese residents during the epidemic period increased, and the qualified rate of handwashing time was improved. |
|
Protective Behavior of Chinese Population Wearing Masks during the COVID-19
Epidemic |
Cao, S, Wen, et al |
Research of Environmental Sciences |
Public Health response| Interventions de santé publique |
In order to find out the mask wearing behavior of Chinese residents during the COVID-19 epidemic, this study analyzed
the behavioral characteristics of residents wearing masks in China's 31 provinces, and discussed the differences of the behavior of wearing masks of the groups in various potential infection risk on the basis of the survey on environmental exposure behavior
patterns of Chinese population during COVID-19 epidemic. The results show that: (1) During the COVID-19 epidemic, more than 99% of Chinese people wore masks outside their homes, which was significantly higher than that of non-epidemic period (16.05%). (2)
Residents mainly had three main patterns to wear masks, i.e., only surgical masks, only disposable surgical masks, and only surgical masks and disposable surgical masks, accounting for more than 60% of a total 31 mask wearing patterns. (3) During the COVID-19
epidemic, there were significant differences in the proportion of wearing masks among different occupational groups, people belonging to different groups and people in different epidemical areas. (4) During the COVID-19 epidemic, the replacement frequency
of masks worn by Chinese residents was usually 4 and 24 hours, respectively. (5) The proportion of people wearing masks outside was positively correlated with the severity of the COVID-19 epidemic. |
|
Carriedo, A, Cecchini, et al |
American Journal of Geriatric Psychiatry |
Public Health response| Interventions de santé publique |
This study is aimed to examine the psychological well-being of older adults during the home isolation due to the COVID-19
pandemic and to investigate whether meeting the World Health Organization's global recommendations on physical activity (PA) for health is associated with their resilience, affect, and depressive symptoms. In this cross-sectional study, a total of 483 citizens
whose ages ranged from 60 to 92 years (overall sample: M = 65.49, SD = 5.14) were recruited via a snowball sampling strategy to answer to an online questionnaire. Four instruments used were The Connor-Davidson CD-RISC resilience scale, The Positive and Negative
Affect Schedule, the six-item self-report scale of Depressive Symptoms, and The international Physical Activity Questionnaire. Results showed that older adults who regularly engaged in vigorous (VPA) and moderate-vigorous physical activity (MVPA) during the
quarantine reported higher scores in resilience (Locus, Self-efficacy, and Optimism), positive affect, and lower in depressive symptoms. These finding are the first quantitative evidence pointing toward a link between engagement in VPA and/or MVPA and resilience,
positive affect, and depressive symptoms within the COVID-19 restrictions in Spain. |
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|
Post-COVID-19 inflammatory syndrome manifesting as refractory status epilepticus |
Carroll, E, Neumann, et al |
Epilepsia |
Clinical data| Données cliniques |
There have been multiple descriptions of seizures during the acute infectious period in patients with COVID-19. However,
there have been no reports of status epilepticus after recovery from COVID-19 infection. Herein, we discuss a patient with refractory status epilepticus 6 weeks after initial infection with COVID-19. Extensive workup demonstrated elevated inflammatory markers,
recurrence of a positive nasopharyngeal SARS-CoV-2 polymerase chain reaction, and hippocampal atrophy. Postinfectious inflammation may have triggered refractory status epilepticus in a manner similar to the multisystemic inflammatory syndrome observed in children
after COVID-19. |
|
Telehealth perceptions in patients with epilepsy and providers during the COVID-19
pandemic |
Casares, M, Wombles, et al |
Epilepsy and Behavior |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
The goal of our survey was to determine the perceptions and satisfaction of patients with intractable epilepsy and
providers with telehealth during the COVID-19 pandemic; we surveyed patient and providers. We evaluated the first 111 patients who participated in our telehealth visits. We conducted telephone surveys with the first 68 patients who agreed to participate. We
also conducted surveys by email with our providers who participated in these telehealth visits. We found that 66% of patients and 67% of providers would use a telehealth visit in the future if given the option. |
|
Clinical characteristics and risk factors for mortality
in hematologic patients affected By COVID-19 |
Cattaneo, C, Daffini, et al |
Cancer |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This is a retrospective cohort study of patients managed at the hematology departments of ASST Spedali Civili in Brescia
and Grande Ospedale Metropolitano Niguarda in Milan (both in Lombardy) who were positive for SARS‐CoV‐2 in the period from March 1 to 31, 2020. One hundred two patients with COVID-19 symptoms and a nasopharyngeal swab positive for severe acute respiratory
syndrome coronavirus 2 seen at 2 hematologic departments located in Lombardy, Italy, during March 2020 were studied. Risk factors for acquiring COVID-19 were analyzed by comparisons of patients with COVID-19 and the standard hematologic population managed
at the same institutions in 2019. Coronavirus disease 2019 (COVID-19) infection occurs across all different types of hematologic disease; however, the risk of acquiring it is lower for patients with chronic myeloproliferative neoplasms, including chronic myeloid
leukemia, and higher for patients with immune-mediated anemia on immunosuppressive treatment. The 30-day mortality rate is 39.2%, which is far higher than the rates for both uninfected hematologic controls (3%; P '.001) and nonhematologic patients with COVID-19
(23.5%; P =.02) despite matching for age, sex, comorbidities, and severity of disease. |
|
Catteau, L, Dauby, et al |
International journal of antimicrobial agents |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
Conducted a retrospective analysis of in-hospital mortality in the Belgian national COVID-19 hospital surveillance
data. Patients treated either with HCQ monotherapy and supportive care (HCQ group) were compared with patients treated with supportive care only (no-HCQ group) using a competing risks proportional hazards regression with discharge alive as competing risk,
adjusted for demographic and clinical features with robust standard errors. Of 8075 patients with complete discharge data on 24 May 2020 and diagnosed before 1 May 2020, 4542 received HCQ in monotherapy and 3533 were in the no-HCQ group. Death was reported
in 804/4542 (17.7%) and 957/3533 (27.1%), respectively. In the multivariable analysis, mortality was lower in the HCQ group compared with the no-HCQ group adjusted hazard ratio (aHR) = 0.684, 95% confidence interval (CI) 0.617–0.758]. Compared with the no-HCQ
group, mortality in the HCQ group was reduced both in patients diagnosed ≤5 days (n = 3975) and >5 days (n = 3487) after symptom onset aHR = 0.701 (95% CI 0.617–0.796) and aHR = 0.647 (95% CI 0.525–0.797), respectively]. |
|
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Cranial nerves impairment in post-acute oropharyngeal dysphagia after COVID-19:
a case report |
Cavalagli, A, Peiti, et al |
Eur J Phys Rehabil Med |
Clinical data| Données cliniques |
CASE REPORT: The patient is a 69-year-old man who presented acquired weakness and dysphagia with clinical cranial nerves
impairment of lingual, IX, X and XII after SARS-CoV-2 infection, without electrophysiological alterations. He underwent rehabilitation program for two months, with slow recovery. However, at discharge residual hypoglossal nerve deficit sign was present. |
|
Cavalli, E, Petralia, et al |
International journal of molecular medicine |
Clinical data| Données cliniques Immunology | Immunologie |
In the present study, a transcriptomic analysis was performed to profile the immune signatures in lung and the bronchoalveolar
lavage fluid samples from COVID-19 patients and controls. Our data concordantly revealed increased humoral responses to infection. The elucidation of the host responses to SARS-coV-2 infection may further improve our understanding of COVID-19 pathogenesis
and suggest better therapeutic strategies. |
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Chakraborty, A, Karmakar, et al |
Iranian Journal of Psychiatry |
Public Health response| Interventions de santé publique |
This study aims to evaluate the effect of COVID-19 on OCD patients. Phone interviews were done with 84 patients previously
diagnosed with obsession of contamination and compulsive washing. Yale Brown Obsessive Compulsive Scale was used and the scores of the participants were compared to their prepandemic scores. Only 5 patients (6%) had exacerbation of symptoms after the COVID-19
pandemic. Handwashing protocol does not aggravate the washing compulsion of patients. Similarly, the fear of infection with COVID-19 does not increase their fear of contamination. |
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Chen, J, Lin, et al |
Expert Rev Respir Med |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
OBJECTIVE: To understand the clinical effectiveness and safety of Shufeng Jiedu Capsules combined with umifenovir (Arbidol)
in the treatment of common-type COVID-19. METHODS: A retrospective cohort study was used to analyze the case data of 200 inpatients diagnosed with common-type COVID-19 at Wuhan Hospital. Participants were divided into a control group and an experimental group.
The control group was treated with Arbidol hydrochloride capsules while the experimental group was treated with combination Arbidol hydrochloride capsules and Shufeng Jiedu Capsules (SFJDC) for 14 days. RESULTS: Defervescence was achieved more rapidly in the
experimental group (P < 0.05). The white blood cell count and the lymphocyte percentage in the experimental group were higher than that of the control group (P < 0.05). CRP and IL-6 levels in the experimental group were significantly lower than those in the
control group (P < 0.05). The proportion of chest CT studies showing resolution of pneumonia in the experimental group was significantly higher than that in the control group (P < 0.05). CONCLUSIONS: A treatment regimen of Shufeng Jiedu Capsules combined with
Arbidol to treat common-type COVID-19, combining traditional Chinese and western allopathic medicine, improves time to recovery, has better clinical effectiveness, and is safe. |
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Chen, M, Wu, et al |
American Journal of Translational Research |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study was designed to assess the levels of human serum amyloid A (SAA) and C-reactive protein (CRP) in patients
with coronavirus disease 2019 (COVID-19) to determine their prognostic value in predicting the severity of disease. Patients with COVID-19 who presented with acute respiratory distress syndrome (ARDS) shared distinct characteristics. In patients with elevated
SAA and CRP levels, the NLR was statistically associated with disease severity. According to the receiver operating characteristic curve analysis, the combined predictive probability of CRP and SAA levels, along with white blood cell count, showed the highest
area under the curve (AUC; 0.878), and was able to distinguish between patients with and without ARDS. The cut-off level for SAA to predict the severity of COVID-19 was 92.900, with a sensitivity of 95.8%, a specificity of 53.7%, and an AUC of 0.712. For patients
with elevated levels of SAA but not CRP, a mild condition was predicted. For patients with elevated levels of both SAA and CRP, and a high NLR, a severe infection was predicted, requiring medical attention. Therefore, CRP and SAA levels demonstrate a prognostic
value for predicting the severity of COVID-19. |
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Chen, SY, Lee, et al |
Emerg Microbes Infect |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This multicenter, retrospective study included 346 serum samples from 74 patients with coronavirus disease 2019 (COVID-19)
and 194 serum samples from non-COVID-19 patients to evaluate the performance of five anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody tests. Found high diagnostic sensitivities (%, 95% confidence interval CI]) for the Roche Test (97.4%,
93.4-99.0%), Abbott Test (94.0%, 89.1-96.8%), Wondfo Test (91.4%, 85.8-94.9%), ASK Test (97.4%, 93.4-99.0%), and Dynamiker Test (90.1%, 84.3-94.0%) after > 21 days of symptom onset. Meanwhile, the diagnostic specificity was 99.0% (95% CI, 96.3-99.7%) for the
Roche Test, 97.9% (95% CI, 94.8-99.2%) for the Abbott Test, and 100.0% (95% CI, 98.1-100.0%) for the three LFIAs. Data suggested that understanding the dynamic antibody response after COVID-19 infection and performance characteristics of different serological
test are crucial for the appropriate interpretation of serological test result for the diagnosis and risk assessment of patient with COVID-19 infection. |
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Chen, ZY, Wang, et al |
Emerging Infectious Diseases |
Clinical data| Données cliniques |
During January-February 2020, coronavirus disease (COVID-19) and tuberculosis were diagnosed for 3 patients in Wuhan,
China. All 3 patients had COVID-19 pneumonia. One severely ill patient died after acute respiratory distress syndrome developed. Clinicians and public health officials should be aware of underlying chronic infections such as tuberculosis in COVID-19 patients.
© 2020 Centers for Disease Control and Prevention (CDC). All rights reserved. |
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Chew, QH, Chia, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
This study aimed to explore changes in psychological responses (perceived stress, traumatic stress, stigma, coping)
over time in residents, as well as their predictors. Collected responses from 274 residents at baseline and 221 residents at 3 months follow-up (timepoint 2) from the National Healthcare Group (NHG) residency programs in Singapore. All residents reported lower
perceived stress and lower perceived stigma compared to baseline. Use of avoidance coping was associated with all three psychological responses (perceived stress, traumatic stress, and stigma) across the two timepoints. Compared to baseline, specific factors
associated with perceived stress and traumatic stress at timepoint 2 were living alone, less problem solving, and seeking social support. |
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Chong, YY, Chien, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
The present study aims to extend our understanding of how illness perceptions, coping, and self-efficacy affect adherence
to precautionary measures among the public. An online survey was administered between April and June 2020 to a sample of 514 Hong Kong citizens. Adjusted structural equation model showed that illness perceptions toward COVID-19 had significant direct effect
on their adherence to precautionary measures (unstandardized β = 0.50, 95% CI, 0.28, 0.80], p = 0.001), and indirect effects through avoidance-based coping (β = −0.10 95% CI, −0.26, −0.01], p = 0.016) and self-efficacy (β = −0.10, 95% CI, −0.18, −0.01], p
= 0.025). These results imply that apart from emphasizing the health hazards of a novel infectious disease, an effective public health intervention and crisis communication should address avoidance-based coping and self-efficacy of the public in adherence
to precautionary measures for COVID-19. |
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Cloutier, L, Merindol, et al |
American Journal of Infection Control |
Epidemiology| Épidémiologie |
Several countries have undertaken social distancing measures to stop SARS-CoV-2 spread. Asymptomatic carriers’ prevalence
is unknown and would provide essential information on hidden viral circulation. In our cross-sectional study, 1.82% of 330 asymptomatic confined individuals living in the community carried SARS-CoV-2 despite no contact with declared cases, raising concerns
about unnoticed transmission. © 2020 |
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Cohen-Mcfarlane, M, Goubran, et al |
IEEE Access |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This article introduces a novel database (NoCoCoDa), which contains COVID-19 cough events obtained through public media
interviews with COVID-19 patients, as an interim solution. After manual segmentation of the interviews, a total of 73 individual cough events were extracted and cough phase annotation was performed. Furthermore, the COVID-19 cough is typically dry but can
present as a more productive cough in severe cases. Most of the NoCoCoDa cough events were recorded either during or after a severe period of the disease, which is supported by the fact that 77% of the COVID-19 coughs were classified as productive based on
our previous work. The NoCoCoDa is designed to be used for rapid exploration and algorithm development, which can then be applied to more extensive datasets and potentially real time applications. |
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Çolakoǧlu, MK, Özgün, et al |
Turkish Journal of Surgery |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to evaluate the knowledge of general surgeons about COVID-19 and understand the attitude
and current situation of our colleagues. his descriptive study comprised general surgeons working in different parts of Turkey. A survey with 23 questions was prepared to determine the demographic characteristics of the participants, workplace characteristics,
change in daily work practices and their attitudes in the pandemic process. A total of 332 forms were evaluated. Survey results show that the majority of surgeons have changed their daily surgical practices. Many surgeons take part in the treatment of COVID-19.
Turkish surgeons have managed to get a quick reaction from the start of the pandemic. However, there are still differences in preoperative patient evaluation and operation selection and precautions during the operation. |
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Impact of COVID-19 pandemic in the activity of a Therapeutic Apheresis unit
in Italy |
Colpo, A, Astolfi, et al |
Transfusion and Apheresis Science |
Healthcare Response | Réponse des soins de santé |
The study retrospectively evaluated the TA activity (procedures performed, patients treated and consultations) during
the COVID-19 pandemic, from March to April 2020, comparing the activity in the same time period in 2018 and 2019. In the period analyzed, a significant reduction in both the total number of procedures performed and of patients treated, respectively by 17 %
and 16 % for the procedures and by 19 % and 20 % for patients treated compared to the same period of 2018 and 2019, respectively, was observed. any reasons determined the observed reduction in the TA activity during the recent COVID-19 outbreak. The AU itself
was quickly reorganized in terms of location and supplies to allow for the appropriate COVID-19 patients care. Many non urgent cases, after multidisciplinary discussion between Clinicians and Apheresis Specialists, were deferred, maintaining close phone and
e-mail contact with patients. |
|
32911647; A universal physics-based model describing COVID-19 dynamics in Europe |
Contoyiannis, Y, Stavrinides, et al |
International Journal of Environmental Research and Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The self-organizing mechanism is a universal approach that is widely followed in nature. In this work, a novel self-organizing
model describing diffusion over a lattice is introduced. Simulation results for the model’s active lattice sites demonstrate an evolution curve that is very close to those describing the evolution of infected European populations by COVID-19. The model was
further examined against real data regarding the COVID-19 epidemic for seven European countries (with a total population of 290 million) during the periods in which social distancing measures were imposed, namely Italy and Spain, which had an enormous spread
of the disease; the successful case of Greece; and four central European countries: France, Belgium, Germany and the Netherlands. The value of the proposed model lies in its simplicity and in the fact that it is based on a universal natural mechanism, which
through the presentation of an equivalent dynamical system apparently documents and provides a better understanding of the dynamical process behind viral epidemic spreads in general—even pandemics, such as in the case of COVID-19—further allowing us to come
closer to controlling such situations. Finally, this model allowed the study of dynamical characteristics such as the memory effect, through the autocorrelation function, in the studied epidemiological dynamical systems. © 2020 by the authors. Licensee MDPI,
Basel, Switzerland. |
|
Corbet, S, Hou, et al |
International Review of Economics and Finance |
Economics | Économie |
Set out to test for the presence of volatility spillovers from Chinese financial markets upon a broad number of traditional
financial assets during the outbreak of the COVID-19 pandemic. Indices are used to specifically measure the performance of Chinese companies who are inherently involved in the R&D and production of materials and products used to mitigate and counteract the
effects of influenza and coronavirus, therefore, such indices present a unique barometer of broad population-based sentiment relating to COVID-19 in comparison to traditional Chinese influenza. Results indicate exceptionally pronounced and persistent impacts
of the coronavirus pandemic upon Chinese financial markets, compared to that of the traditional and long-standing influenza index. COVID-19 is found to have had a substantial effect on directional spillovers upon the Bitcoin market. |
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Healthcare-associated sars-cov-2 transmission—experiences from a german university
hospital |
Correa-Martínez, CL, Schwierzeck, et al |
Microorganisms |
Epidemiology| Épidémiologie Transmission |
During the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, healthcare systems worldwide
have to prevent nosocomial SARS-CoV-2 transmission while maintaining duty of care. In our study, we characterize the transmission dynamic of SARS-CoV-2 in inpatients and healthcare workers (HCWs) at the University Hospital Münster (UHM) in northwest Germany.
We identified 27 cases of healthcare-associated SARS-CoV-2 infections (4 inpatients and 23 HCWs) who had contact with patients and/or HCWs without the use of adequate PPE. The contacts of these index cases were followed up for SARS-CoV-2 infection after unprotected
exposure and a quantitative measure of probability of becoming infected, the attack rate, was calculated. In addition, transmission was evaluated in the context of infection control measures established during the pandemic and we compared the epidemiological
data of all index cases, including symptoms and Ct values of virology test results. The overall attack rate in the hospital setting was 1.3% (inpatients 0.9%, HCWs 1.6%). However, during an outbreak, the attack rate was 25.5% (inpatients 20.0%, HCWs 29.6%).
For both scenarios, HCWs had a higher attack rate illustrating their role in healthcare-associated SARS-CoV-2 transmission. Taken together, our experiences demonstrate how infection control measures can minimize the transmission of SARS-CoV-2 in the healthcare
setting. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
|
Cosma, L, Sollaku, et al |
J Med Imaging Radiat Oncol |
Clinical data| Données cliniques |
We report the case of who has been hospitalized complaining about fever in the last 4 days. Laboratory data revealed
lymphocytopenia and leucopenia with an elevation of C-reactive protein and positive real-time reverse transcription-polymerase chain reaction (RT-PCR). Six days before this hospitalization, when the patient was asymptomatic, (18) F-FDG PET/CT images were performed
for the therapeutic control of liver metastases of colorectal cancer. Lung abnormality findings at (18) F-FDG PET/CT images, unrelated to cancer metastases, but suspicious for viral infection, may suggest the presence of COVID-19 disease in its early phase
before symptoms onset. Since PET/CT is more sensitive than CT scan in detecting host's reaction, the added value of this technique could be monitoring disease progression and could be used as a biomarker of lung disease activity and therefore as an important
tool for a better understanding of the factors that contribute to the progression of lung disease. |
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Covas Moschovas, M, Bhat, et al |
J Endourol |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
To report our experience and lessons learned as high-volume center of robotic surgery managing patients with prostate
cancer since the beginning of the COVID-19 pandemic in our center. We described some critical changes in our routine to minimize the COVID infection among patients and healthcare workers. From March 1st to May 25th, 2020, we described our actions and surgical
outcomes of patients treated in our center during the pandemic. Our experience managing patients with prostate cancer during the COVID-19 pandemic showed that changing the office routine, stratifying the patients according to the NCCN risk, and adopting COVID-based
criteria to select patients for surgery are necessary actions to maintain the best quality of treatment and minimize the viral infection among our oncological patients. |
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First-time Diabetic Ketoacidosis in Type 2 Diabetics With Covid-19 Infection:
A Novel Case Series |
Croft, A, Bucca, et al |
Journal of Emergency Medicine |
Clinical data| Données cliniques Coronavirology| Coronavirologie |
We have identified a series of patients with diabetic ketoacidosis (DKA) likely precipitated by coronavirus disease
2019 (COVID-19). Case Series: We describe 5 patients with previously known type 2 diabetes and no history of DKA, who presented to the emergency department with new-onset DKA and COVID-19. Diabetes mellitus is a known risk factor for poor outcomes in viral
respiratory illnesses, including COVID-19. Infection may precipitate DKA in patients with type 2 diabetes. |
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Cunill, M, Aymerich, et al |
International Journal of Mental Health Promotion |
Healthcare Response | Réponse des soins de santé |
Aim: To describe the physical and psychological symptoms in healthcare workers caring for COVID-19 patients. Methods:
Cross-sectional descriptive study design. A sample of 1,452 participants was collected. Sociodemographic data were recorded. Symptoms of anxiety were screened with Generalized Anxiety Disorder (GAD-7), symptoms of depression were measured with the Patient
Health Questionnaire (PHQ-9), and finally physical symptoms were measured using the Patient Health Questionnaire (PHQ-15). Percentages, means and standard deviations, the one-way and two-way ANOVA test, the Chi square test and Pearson’s correlation coefficient
were all calculated. The level of significance was (p < 0.05). Results: Medium levels of anxiety (range, 5–9) and depression (range, 5–9) were observed, as well as the existence of physical symptoms (5–30). Nursing staff presented higher scores for anxiety
than medical staff (Bonferroni test = −1.68; p < 0.001). Significant differences were also found for depression (F = 9.8; p < 0.001). Nursing staff and assistant nursing staff presented higher scores than medical professionals (Post hoc test = −2.11; p < 0.001
and Post hoc test = −1.53; p < 0.001, respectively). Significant differences were found according to gender in all variables referring to emotional distress: anxiety (t student = −6.492; p < 0.001), depression (t student = −4.703; p < 0.001) and physical symptoms
(t student = −9.015; p < 0.001). Female healthcare workers displayed anxiety, depression and physical symptoms more frequently than their male counterparts. Analysing gender differences within each professional activity, no significant differences were found
using the two-way ANOVA test (F = 1.52; p = 0.109). Anxiety and depression correlated with physical symptoms (rxy = 0.604; p < 0.001) when applying Pearson’s correlation coefficient. Conclusions: The study confirms the psychological impact and manifestation
of physical symptoms in healthcare workers during the COVID-19 outbreak, highlighting the need to monitor symptoms and provide effective psychological intervention to prevent adverse effects on mental health such as post-traumatic stress disorder and burnout.
© 2020, Tech Science Press. All rights reserved. |
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Damirchi, ES, Mojarrad, et al |
Iranian Journal of Psychiatry |
Public Health response| Interventions de santé publique |
The purpose of this study was to investigate the role of self-talk in predicting death anxiety, obsessive-compulsive
disorder, and coping strategies in the face of COVID-19. This descriptive and correlational study was conducted on 354 adults living in Ardabil, Iran, who were selected using cluster sampling from 21 January to 19 March 2020. Self-Talk questionnaires, Coping
Strategies, Death Anxiety, and Obsessive-Compulsive questionnaires were used for data collection. Descriptive statistics, Pearson correlation, and multiple linear regression were used for data analysis. he findings revealed a significant positive relationship
between self-talk and problem-centered coping style. Also, significant negative relationships were found between self-talk and emotional coping style, death anxiety, and obsessive-compulsive disorder. The results of this study emphasize the need for psychological
crisis intervention during the COVID-19 outbreak. |
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Lessons of mortality following covid-19 epidemic in the united states especially in the
geriatrics |
Daneshfar, M, Dadashzadeh, et al |
Journal of Nephropharmacology |
Epidemiology| Épidémiologie Transmission |
This study aimed to compare the transmission of coronavirus between metropolitan and non-metropolitan counties as lessons
of mortality (especially in geriatric) following COVID-19 epidemic. The USAFact.org public website (https://usafacts.org/visualizations) was used to determine the transmission between metro and non-metropolitan counties. In this study, four different time
periods were considered for the COVID-19 incremental trend (April 1, May 1, June 1, and July 1, 2020). In metropolitan counties, the spread of COVID-19 is very fast, which is significantly different from the non-metro counties (P < 0.001). The results show
the sharp increasing trend of infected people in metropolitan counties. According to the results, susceptible people especially the elderly should move to non-metropolitan counties during the COVID-19 pandemic to be less likely at risk. |
|
Pooled Testing for Surveillance of SARS-CoV-2 in Asymptomatic Individuals |
Das, S, Lau, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Instituted a manual pooling strategy to screen asymptomatic healthcare workers. In addition to the validation of
optimum pool size to determine any reduction in sensitivity that would potentially result in false negative results at or near the lower limit of detection, also instituted measures to reduce pre-test errors during accessioning and pooling. Three different
schemes using ten (n =5), seven (n =3) and five specimens (n =3) per pool were analyzed. Varying number of positive specimens (ranging from one to three) were used to prepare contrived pools. Conclude that 10-specimen manual pooling algorithm maintaining a
unidirectional workflow is effective for surveillance testing of SARS-CoV-2 in asymptomatic healthcare workers. |
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The epidemiological characteristics of COVID-19 in Libya during the ongoing-armed
conflict |
Daw, MohamedA, El-Bouzedi, et al |
Research Square prepub |
Epidemiology| Épidémiologie |
This study analyzed the epidemiological situation of the COVID-19 pandemic in Libya, examined the impact of the armed
conflict in Libya on the spread of the pandemic, and proposes strategies for dealing with the pandemic during this conflict. Collected the available information on all COVID-19 cases in the different regions of Libya, covering the period from March 25 to May
25, 2020. A total of 698 cases of COVID-19 were reported in Libya during a period of three months. The number of cases varied from one region to another and was affected by the fighting. The largest number of cases was reported in the southern part of the
country, which has been severely affected by the conflict in comparison to the eastern and western parts of the country. This study describes the epidemiological pattern of COVID-19 in Libya and how it has been affected by the ongoing armed conflict. This
conflict seems to have hindered access to populations and thereby masked the true dimensions of the pandemic. |
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de la Cruz-Benito, B, Lázaro-del Campo, et al |
British journal of haematology |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The COVID-19 pandemic has dramatically challenged care for cancer patients, especially those with active treatment
who represent a vulnerable population for SARS-CoV-2 infection. Aggressive lymphoid neoplasms, such as diffuse large B cell lymphoma and high-grade B cell lymphoma, need to be treated without delay in order to get the best disease outcome. Because of that,
our clinical practice was changed to minimise the risk of SARS-CoV-2 infection while continuing haematological treatment. In this report, we analyse the management of front-line therapy in 18 patients during the COVID-19 outbreak, as well as the results of
the implemented measures in their outcome |
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Paradoxical effect of SARS-CoV-2 infection in patients with immune
thrombocytopenia |
de la Cruz-Benito, B, Rivas-Pollmar, et al |
British journal of haematology |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
Thrombocytopenia has been identified as a common complication of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
infection in the general population. In an attempt to determine the impact of coronavirus disease 2019 (COVID-19) in patients with immune thrombocytopenia (ITP), a retrospective single-centre study was performed. Thrombocytosis was observed in patients with
chronic ITP after SARS-CoV-2 infection, frequently needing treatment adjustment or even discontinuation of therapy. Relapses and newly diagnosed cases showed a fast response after initial treatment compared to ITP. Reduced immune activity due to lymphopenia
during COVID-19 could explain this paradoxical effect, although further studies are needed. |
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Preliminary data on COVID-19 in patients with hemoglobinopathies: A multicentre ICET-A
study |
de Sanctis, V, Canatan, et al |
Mediterranean Journal of Hematology and Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aims to investigate, retrospectively, the epidemiological and clinical characteristics, laboratory
results, radiologic findings, and outcomes of COVID-19 in patients with transfusion-dependent β thalassemia major (TM), β-thalassemia intermedia (TI) and sickle cell disease (SCD). A total of 17 Centers, from 10 countries, following 9,499 patients
with hemoglobinopathies, participated in the survey. total of 13 patients, 7 with TM, 3 with TI, and 3 with SCD, with confirmed COVID-19, were identified in 6 Centers from different countries. total of 13 patients, 7 with TM, 3 with TI, and 3 with SCD, with
confirmed COVID-19, were identified in 6 Centers from different countries. ix patients had pneumonia, and 4 needed oxygen therapy. Increased C-reactive protein (6/10), high serum lactate dehydrogenase (LDH; 6/10), and erythrocyte sedimentation rate (ESR; 6/10)
were the most common laboratory findings. 6/10 patients had an exacerbation of anemia (2 with SCD). In the majority of patients, the course of COVID-19 was moderate (6/10) and severe in 3/10 patients. The presence of associated co-morbidities can aggravate
the severity of COVID- 19, leading to a poorer prognosis irrespective of age. |
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When residents work less, they feel better: Lessons learned from an unprecedent
context of lockdown |
Degraeve, A, Lejeune, et al |
Progres en Urologie |
Public Health response| Interventions de santé publique |
Assessed the psychological impact of the lockdown on Belgian residents in urology and their resounding on the quality
of the training. A self-administered anonymous questionnaire assessing the risk of burnout in a pandemic situation and its impact on the quality of the training was e-mailed to the members of the European Society of Residents in Urology of Belgium (ESRU-B).
Fifty percent (62/126) of the ESRU-B members replied to the questionnaire. 93% of the responders reported a negative impact on the quality of their practical training (CI95 = 0.07–1.10]; P = 0.83), 56% and 61.7% reported a positive impact of the crisis on
their life and on their theoretical training respectively. espite a negative impact on the daily work quality, the decrease in activity induced by the lockdown did not have a negative psychological impact on Belgian residents in urology. |
|
Del Pino, LB, Campos, et al |
Revista Cubana de Pediatria |
Clinical data| Données cliniques |
This case report describes the characteristics of an asymptomatic pediatric patient with pneumonia caused by SARS-CoV-2.
At admission, pneumonia was diagnosed by X-ray and SARS-CoV-2 by PCR. Treatment with kaletra chloroquine ceftriaxone was started, with evident improvement during the hospital stay. |
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Toward to establish selection criteria for rapid serological tests for COVID-19 |
Delgado, G, Vargas, et al |
Infectio |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
In order to characterize the humoral immune response, we analyzed eight immuno-chromatographic tests and one ELISA
test, as a verification or secondary validation analysis using positive and negative control serum samples. Of all these rapid tests, only 4 exhibit clear banding patterns for IgG and two of these also showed results for IgM (only in a few symptomatic patients).
Instead, with an ELISA test a preferential recognition was observed for symptomatic patients who were critically ill, whereas in asymptomatic individuals it did not show more than 25% of positivity. |
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COVID-19 patients exhibit reduced procoagulant platelet responses |
Denorme, F, Manne, et al |
J Thromb Haemost |
Clinical data| Données cliniques Animal model | Modèle animal |
The objective of this study was to examine if procoagulant platelets formation is altered in COVID-19 patients and
if procoagulant platelets contribute to pulmonary thrombosis. We observed that platelets isolated from COVID-19 patients had a reduced ability to become procoagulant compared to those from matched healthy donors. Mice with platelets lacking cyclophilin D died
significantly faster from pulmonary microvascular thrombosis compared to littermate wild-type controls. These results suggest dysregulated procoagulant platelet responses may contribute to thrombotic complications during SARS-CoV-2 infection. |
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Ace2 protein landscape in the head and neck region: The conundrum of SARS-CoV-2 infection |
Descamps, G, Verset, et al |
Biology |
Clinical data| Données cliniques |
This study aims to investigate ACE2 protein expression in several sites of the upper aerodigestive tract in order to
highlight potential routes of infection. Surprisingly, we obtained different results depending on the antibody, an absence of labeling having been observed with a monoclonal antibody raised against the extracellular domain, whereas the polyclonal, against
the cytoplasmic part of the protein, revealed enriched ACE2 expression, particularly in sinuses, vocal cords, salivary glands and oral cavity epithelial cells. |
|
Dhavale, P, Koparkar, et al |
Indian Journal of Palliative Care |
Healthcare Response | Réponse des soins de santé |
The aim of this article is to describe the range of challenges faced by both palliative care patients and caregivers
during the lockdown due to the COVID-19 pandemic. Telephonic and video calls play an important role in supporting patients and caregivers and in the most critical cases. However, it is also important to find the ways to provide direct home-based support to
patients and families at this time so that they feel less alone, cope better, and experience meaningful support to build their resilience. |
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Di Castelnuovo, A, Bonaccio, et al |
Nutrition, Metabolism and Cardiovascular Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this retrospective observational study on 3894 patients with SARS-CoV-2 infection hospitalized from February 19th
to May 23rd, 2020 throughout Italy, we aimed to identify baseline characteristics predisposing COVID-19 patients to in-hospital death. Impaired renal function, elevated C-reactive protein and advanced age were major predictors of in-hospital death. |
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Di Cristanziano, V, Meyer-Schwickerath, et al |
Bone Marrow Transplant |
Clinical data| Données cliniques Immunology | Immunologie |
This report describes for the first time the detection of SARS-CoV-2 viremia prior to the onset of symptoms and diagnosis
of COVID-19 in a 51-year-old patient with acute myeloid leukemia (AML) and relapse after allogeneic hematopoietic stem cell transplantation. Notably, we illustrate that SARS-CoV-2 viremia inversely correlates with anti-SARS-CoV-2 antibody production, which
predates negativity in respiratory samples for 4 weeks. |
|
|
Di, G, Xia, et al |
Risk Management and Healthcare Policy |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
The aim of this study was to describe the characteristics of patients requiring emergency surgery in a COVID-19 outbreak
area (Wuhan) from Jan 23 - Feb 15, 2020. Twenty-five of 88 patients presented with abnormalities observed on chest CT scans and 16 presented with fever. The median wait time for surgery was one day and the median postoperative length of stay was five days.
Compared with patients not suspected of COVID-19 infection, six patients were confirmed to be infected with COVID-19 in the suspected group. No health care workers were infected during this study period. |
|
|
Diao, L, Yang, et al |
Heart Surgery Forum |
Clinical data| Données cliniques Animal model | Modèle animal |
The objective of this study was to explore the effect of atrial septal defect (ASD) and venoarterial extracorporeal
membrane oxygenation (VA-ECMO) in the treatment of ARDS combined with left ventricular dysfunction (LVD) to find a new effective method for treating severe COVID-19 patients. Five large animal ARDS models of sheep were established. ASD plus VA-ECMO was shown
to be an effective method for the treatment of ARDS combined with LVD. |
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PMC7406213; COVID-19 Ischemic Strokes as an Emerging Rehabilitation Population:
A Case Series |
Diaz-Segarra, N, Edmond, et al |
Am J Phys Med Rehabil |
Clinical data| Données cliniques |
We present four cases of coronavirus disease 2019 ischemic strokes occurring in patients aged 37-68 yrs with varying
coronavirus disease 2019 infection severities, premorbid risk factors, clinical presentations (eg, focal and nonfocal), and vascular distributions. |
|
Guillain-Barré-Strohl syndrome and COVID-19: Case report and literature review |
Diez-Porras, L, Vergés, et al |
Neuromuscular Disorders |
Clinical data| Données cliniques |
We report the case of a 54-year old patient with acute demyelinating polyneuropathy during infection by SARS-CoV-2
who progressed clinically to require assisted ventilation. After several weeks of specific symptomatic treatment, the patient had a favorable outcome. |
|
Dolci, G, Prevedello, et al |
J Cardiovasc Med (Hagerstown) |
Public Health response| Interventions de santé publique |
This study describes an unusual case of mid-ventricular ballooning Takotsubo syndrome in a 64 year old woman. It was
revealed that symptoms began just after the enforcement of lockdown measures. The patient acknowledged that she was very anxious and worried by the risk of COVID-19 contagion and the limitations of daily living and social activities. The authors believe the
COVID-19 pandemic was an emotional trigger in this case. |
|
|
dos Santos Lima, Leonardo |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We propose a stochastic model for epidemic spreading of the novel coronavirus based in data supported by the Brazilian
health agencies. Furthermore, we performed an analysis using the Fokker-Planck equation estimating the novel cases in the day t as the mean half-width of the distribution of novel cases P(N,t). Our results display that the model based in the Itô diffusion
adjusts well to the results supplied by health Brazilian agencies due to large uncertain in the official data and to the low number of tests realized in the population. |
|
|
Duan, P, Deng, et al |
Epidemiol Infect |
Epidemiology| Épidémiologie Immunology | Immunologie |
We reported the results of health screening for COVID-19 among returned staff of a hospital in China and conducted
a summary analysis to provide valuable experience for curbing the COVID-19 epidemic and rebound. In total, 4729 returned staff were screened by physical examination for the first time, four cases (2.33%) were transferred to the isolation treatment of the
hospital. Two of these patients had positive initial SARS-CoV-2 nucleic acid test; one patient had negative initial SARS-CoV-2 nucleic acid test but showed positive after reexamination; the other one had negative multiple SARS-CoV-2 nucleic acid test, but
had high SARS-CoV-2 antibody level and chest CT showed multiple ground-glass density patches in both lungs. In total, 120 employees (2.54%) had positive results for antibodies (IgG or IgM). |
|
|
Dumantepe, M, Aydin, et al |
Heart Lung and Circulation |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study reported the incidence of venous thromboembolism (VTE) and subsegmental pulmonary embolism with or without
deep vein thrombosis (DVT) in COVID-19 patients admitted to hospital in Istanbul, Turkey. Of the total COVID-19 patients admitted to hospital, 12 (3.4%) died, 273 (77.5%) were discharged alive and 67 (19.1%) were still in the hospital on 25 May 2020. Venous
thromboembolic events occurred in 58 patients with a cumulative rate of 16.4% during the study period. The surprising discovery was that DVT was not identified in 20 (86.9%) of the 23 patients with subsegmental pulmonary embolism, which corroborates the pulmonary
immunothrombosis theory. |
|
|
Edalatifard, M, Akhtari, et al |
Eur Respir J |
Therapeutics| Thérapeutique RCT |
We conducted a single-blind, randomised, controlled, clinical trial of methylprednisolone involving severe hospitalised
patients with confirmed COVID-19 at the early pulmonary phase of the illness in Iran. Patients with clinical improvement were higher in the methylprednisolone group than in the standard care group (94·1% versus 57·1%), and the mortality rate was numerically
lower in the methylprednisolone group (5·9% versus 42.9%; p <0·001). |
|
|
Efe, C, Simşek, et al |
Expert Rev Gastroenterol Hepatol |
Healthcare Response | Réponse des soins de santé |
We aimed to evaluate the feasibility of telehealth in the management of patients with autoimmune hepatitis (AIH) in
Turkey before and during the COVID-19 pandemic. The telehealth group maintained remission significantly better than the standard care group (100% vs. 77.3%, p=0.035) during the COVID-19 period. We show for the first time that telehealth is a feasible alternative
for managing AIH, both under normal circumstances and during the COVID-19 pandemic. |
|
|
Public awareness in Egypt about COVID-19 spread in the early phase of the pandemic |
Elgendy, MO, El-Gendy, et al |
Patient education and counseling |
Public Health response| Interventions de santé publique |
This study aimed to evaluate public awareness in Egypt related to the coronavirus. Overall, the study participants’
had good knowledge of coronavirus and the international efforts to confront the coronavirus. |
|
Autopsy Findings in 32 Patients with COVID-19: A Single-Institution Experience |
Elsoukkary, SS, Mostyka, et al |
Pathobiology |
Clinical data| Données cliniques |
We report the clinicopathologic findings from 32 autopsy studies conducted on patients who died of COVID-19. The majority
of severely affected patients have significant pulmonary pathology. However, many patients also have widespread microscopic thromboses, as well as characteristic findings in the liver and lymph nodes. |
|
Elvidge, CD, Ghosh, et al |
Remote Sensing |
Public health interventions*| Interventions de santé publique |
A satellite survey of the cumulative radiant emissions from electric lighting across China reveals a large radiance
decline in lighting from December 2019 to February 2020-the peak of the lockdown established to suppress the spread of COVID-19 infections. The results indicate that it should be feasible to monitor declines and recovery in economic activity levels using nighttime
lighting as a proxy. |
|
|
Entrenas Castillo, M, Entrenas Costa, et al |
Journal of Steroid Biochemistry and Molecular Biology |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We evaluated the effect of calcifediol treatment, on Intensive Care Unit Admission and Mortality rate among Spanish
patients hospitalized for COVID-19. Our study demonstrated that administration of a high dose of Calcifediol or 25-hydroxyvitamin D, significantly reduced the need for ICU treatment of patients requiring hospitalization due to COVID-19. Thus, Calcifediol seems
to be able to reduce severity of the disease. |
|
|
Awareness and perceptions related to COVID-19 among cancer patients: A survey in oncology
department |
Erdem, D, Karaman, et al |
Eur J Cancer Care (Engl) |
Public Health response| Interventions de santé publique |
The primary goal of this study was to assess the knowledge, perceptions and attitude of patients with cancer towards
the COVID-19 pandemic. In general, participants had a positive attitude towards protective measures. No delay for current cancer treatments or appointments was observed in 98% of patients. Nearly two-third of patients could not identify the three most common
symptoms of COVID-19 and half of them were not aware of the routes of transmission. |
|
The Lombardy Emergency Medical System faced with COVID-19: the impact of out-of-hospital
outbreak |
Fagoni, N, Perone, et al |
Prehosp Emerg Care |
Healthcare Response | Réponse des soins de santé |
This retrospective cohort study compares the events managed by the dispatch center and the characteristics of the patients
transported to the hospital managed by the Emergency Medical System (EMS) between March - April, 2020 and 2019 in Lombardy, Italy. "Breathing" or "Infective" events reported to the dispatch center increased more than ten-fold in March 2020, deaths increased
+246%, and patients not transported to hospital +481%. The emergency departments doubled the admission of critically ill patients. |
|
Fallon, B, Lefebvre, et al |
Child Abuse and Neglect |
Public Health response| Interventions de santé publique Economics | Économie |
Given the range of negative consequences related to the COVID-19 pandemic and the evolving supports available to families,
child protection workers needed a clinical tool to guide and support work with families informed by an understanding of economic hardship. The objective of this paper is to report on the development and implementation strategy of an online checklist-style
tool to be used for practice intervention during the pandemic. The tool's development and implementation occurred through an academic/child welfare sector partnership involving child welfare agencies representing diverse regions and populations in Ontario,
Canada. The final version of the clinical tool is a succinct checklist of 12 questions and associated resources that workers can use when assessing families’ needs during the COVID-19 pandemic. |
|
|
Fehdi, MA, Erragh, et al |
Pan African Medical Journal |
Clinical data| Données cliniques |
We report a case of virus reactivation in a 69 year old male COVID-19 patient with acute respiratory distress syndrome
(ARDS). The patient died due to multi-organ failure secondary to cytokine storm. |
|
|
The association between stress and illness anxiety during the corona-virus
outbreak in China in 2019 |
Feihuan, C, Sollman, et al |
International Journal of Body, Mind and Culture |
Public Health response| Interventions de santé publique |
This cross-sectional study investigated the association between stress and illness anxiety during the COVID-19 pandemic
in China. After adjusting for covariates, the OR of mild, moderate, and severe stress reaction level was 3.32, 6.01, and 14.54, respectively. The severe stress reaction is associated with severe illness anxiety during the outbreak of COVID-19 in China. |
|
Ferchiou, Ahmed, Bornet, et al |
Research Square prepub |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique Economics | Économie |
A bioeconomic model was developed to support the long-term lockdown lift strategy for Toulouse. Optimization under
constraint to find the best combination of scenarios and options was performed on the minimal total cost for production losses due to contracted activities and hospitalization in the short and mid-term, with 3 criteria: mortality, person-days locked and hospital
saturation. The results clearly show little difference between the scenarios based on the economic impact or the 3 criteria. This means that policy makers should focus on individuals’ behaviours more than on trying to optimize the lockdown strategy (defining
who is unlocked and who is locked). |
|
|
Fernandez, A |
ACS Medicinal Chemistry Letters |
Coronavirology| Coronavirologie |
Mutation D614G in the spike (S) protein has become dominant, and recent evidence suggests it yields a more stable phenotype
with higher transmission efficacy. We carry out a structural analysis that provides mechanistic clues on the enhanced infectivity. The D614G substitution creates a sticky packing defect in subunit S1, promoting its association with subunit S2 as a means to
stabilize the structure of S1 within the S1/S2 complex. The results raise the therapeutic possibility of immunologically targeting the epitope involved in stabilizing the G614 phenotype as a means of reducing the infection efficacy of SARS-CoV-2. |
|
|
Fong, BYF, Wong, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
This study aims to examine the changes in physical health, mental health, and social well-being experienced by local
residents in Hong Kong who were homebound during the COVID-19 pandemic. The questionnaire found that individuals aged 18 to 25 years spent more time resting and relaxing but experienced more physical strain and depression. Working status was associated with
social contact, with participants working full-time jobs scoring higher in “maintaining social communication via electronic means” and “avoiding social activities outside the home”. |
|
|
Improved detection of antibodies against SARS-CoV-2 by microsphere-based antibody assay |
Fong, CHY, Cai, et al |
International Journal of Molecular Sciences |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we developed and evaluated a novel microsphere-based antibody assay (MBA) for detecting immunoglobulin G against
SARS-CoV-2 nucleoprotein and spike protein receptor binding domain. Time-to-seropositivity and signal-to-cutoff (S/CO) ratio were compared between MBA and enzyme immunoassay. MBA could better differentiate between COVID-19 patients and negative controls with
higher S/CO ratio for COVID-19 patients, lower S/CO ratio with negative controls and fewer specimens in the equivocal range. |
|
Acute Exacerbation of Interstitial Lung Disease as a Sequela of COVID-19 Pneumonia |
Fonseca, M, Summer, et al |
American Journal of the Medical Sciences |
Clinical data| Données cliniques |
Here, we present a case of a patient with Rheumatoid Arthritis (RA) associated interstitial lung disease (RA-ILD) recently
hospitalized due to COVID-19. A 60-year-old woman with RA presented with six days of dyspnea on exertion associated with a dry cough. In the weeks prior, the patient noted malaise, subjective fevers, and upper respiratory symptoms. The patient had previously
been diagnosed with RA-ILD. One month after the hospitalization, the patient was still requiring oxygen supplementation and her pulmonary function tests showed deterioration when compared to the prior year |
|
In Vitro Efficacy of a Povidone-Iodine Nasal Antiseptic for Rapid Inactivation of
SARS-CoV-2 |
Frank, S, Brown, et al |
JAMA Otolaryngol Head Neck Surg |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
Nasal decontaminants have been advocated to sterilize the nasal cavity in patients and health care workers to mitigate
transmission. The objective of this study was to evaluate the in vitro efficacy of PVP-I nasal antiseptic for the inactivation of SARS-CoV-2. Povidone-iodine nasal antiseptic solutions at concentrations as low as 0.5% rapidly inactivate SARS-CoV-2 at contact
times as short as 15 seconds. Intranasal use of PVP-I has demonstrated safety at concentrations of 1.25% and below and may play an adjunctive role in mitigating viral transmission beyond personal protective equipment. Widespread use of PVP-I nasal antiseptic
in patients prior to intranasal procedures could significantly decrease risk of virus transmission via droplet and aerosol spread. |
|
Geriatric patient with covid-19 infection and common complications |
Gala Serra, C |
Revista Espanola de Geriatria y Gerontologia |
Clinical data| Données cliniques |
Our case concerns an 86-year-old patient who was admitted to the geriatric acute service of our hospital, after being
discharged 15 days ago from the same service due to an episode of heart failure. On this occasion, he was admitted with dyspnea and cough. The case presented with atypical clinical signs such as confusional syndrome and the appearance of secondary geriatric
syndromes such as functional deterioration and protein-calorie malnutrition. After 2 cycles of treatment and supportive treatment, the patient presented complete resolution. |
|
The Effect of the COVID-19 Pandemic on Pediatric Intestinal Failure Healthcare Delivery |
Galloway, DP, Mathis, et al |
JPEN J Parenter Enteral Nutr |
Healthcare Response | Réponse des soins de santé |
We sought to ascertain the effects of the COVID-19 pandemic on healthcare delivery for pediatric patients with intestinal
failure (IF). Responses from 29 centers were included in analysis. Centers that followed >50 patients on parenteral nutrition (PN) were more likely to have social workers present in telemedicine visits and observed more central line difficulties among families.
Centers located in states with <40,000 reported cases of COVID-19 saw patients less frequently and were more likely to withhold changes to PN prescriptions. Additionally, the survey revealed a significant degree of financial hardship and food insecurity among
families. |
|
Aortic Arch Thrombus and Pulmonary Embolism in a COVID-19 Patient |
Gandotra, P, Supariwala, et al |
Journal of Emergency Medicine |
Clinical data| Données cliniques |
We present a case of COVID-19-associated aortic thrombus in an otherwise healthy patient. A 53-year-old woman with
no past medical history presented with a 10-day history of dyspnea, fever, and cough. She was positive for SARS-CoV-2. Computed tomography of the chest with i.v. contrast was positive for bilateral ground-glass opacities, scattered filling defects within
the bilateral segmental and subsegmental pulmonary arteries, and a large thrombus was present at the aortic arch. The patient was admitted to the intensive care unit and successfully treated with unfractionated heparin, alteplase, and argatroban. |
|
Ventilation Frequency and Duration of Chinese Population Opening Window
during the COVID-19 Epidemic |
Gao, F, Xu, et al |
Research of Environmental Sciences |
Public Health response| Interventions de santé publique |
This study analyzes the window opening patterns of people in different regions during the COVID-19 outbreak and provides
information on the frequency and duration of window ventilation obtained through an electronic questionnaire survey administered in China. This study indicates that 99.7% of the residents had window ventilation behavior, and the daily ventilation time in
various regions was in the range of 93-126 min during the COVID-19 epidemic, which was shorter than that during the non-epidemic period. |
|
Gao, S, Rao, et al |
JAMA network open |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
The objective of this cross-sectional study was to examine the association between the rate of human mobility changes
and the rate of confirmed cases of SARS-CoV-2 infection. Data from more than 45 million anonymous mobile phone devices were analyzed. The correlation between the COVID-19 increase rate and travel distance decrease rate was -0.586 and the correlation between
COVID-19 increase rate and home dwell time increase rate was 0.526. Increases in state-specific doubling time of total cases ranged from 1.0 to 6.9 days before stay-at-home orders were enacted to 3.7 to 30.3 days after stay-at-home social distancing orders
were put in place. |
|
|
Gaspari, CH, Assumpção, et al |
Phys Ther |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
The purpose of this case report was to describe the role of physical therapists in a neurosurgical center that was
converted into a COVID-19 center for critically ill patients. A total of 116 confirmed COVID-19 cases were treated from March 17 to May 17, 2020. Eighty-nine percent (103) underwent mechanical ventilation during hospitalization, of which 11% (11) were successfully
extubated. Of the total patients, 57 patients died (mortality rate of 49%). The authors conclude that physical therapists in the ICU can facilitate care for critical events such as intubation, patient positioning, ventilatory adjustments, extubation, and functional
training. |
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|
Gazzaruso, C, Paolozzi, et al |
Nutrition, Metabolism and Cardiovascular Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Clinical efficacy of heparin is due to its interaction with antithrombin (AT) that may be decreased in COVID-19. Therefore,
we correlated AT levels with outcomes of COVID-19. Our data first suggest that AT is strongly associated with mortality in COVID-19. In addition, AT may be the link between obesity and a poorer prognosis in patients with COVID-19. |
|
|
A case of inappropriate antidiuretic hormone secretion syndrome associated with COVID-19
pneumonia |
Gemcioglu, E, Karabuga, et al |
Acta Endocrinologica |
Clinical data| Données cliniques |
A 65-year-old female patient with sarcoidosis, cronic obstructive lung disease, hypertension and congestive heart failure
presented to the emergency department with shortness of breath and fever. Oropharyngeal swab for Covid-19 PCR test was positive. After the initiation of treatment, the patient developed hyponatremia. This case is remarkable because there is no reported case
of Covid-19 and inappropriate ADH syndrome coexistence and it demonstrates that there may be a correlation between Covid-19 infection prognosis and hyponatremia. |
|
Undergraduates’ learning habits amid covid-19 pandemic: A pilot study |
Ghazali, N, Zain, et al |
Journal of Advanced Research in Dynamical and Control Systems |
Public Health response| Interventions de santé publique |
This study investigated the effects of COVID-19 pandemic on students’ performance based on their learning habits. A
quantitative method was used to collect data from undergraduates with different sociodemographic and psychological attributes. The empirical evidence of this study could be utilized to develop a prediction model that is able to predict the students’ performance
and a set of relevant features that contribute to student’s performance. The results also could be a foundation for higher education departments to produce more sustainable regulations and policies that may improve students’ self-learning and self-efficacy. |
|
Gherghina Ș, C, Armeanu, et al |
Int J Environ Res Public Health |
Public Health response| Interventions de santé publique Economics | Économie |
This paper examines the linkages in financial markets during COVID-19 pandemic outbreak. For this purpose, daily stock
market returns were used over the period of December 31, 2019-April 20, 2020 for the following economies: USA, Spain, Italy, France, Germany, UK, China, and Romania. The study applied the autoregressive distributed lag (ARDL) model to explore whether the Romanian
stock market is impacted by the crisis generated by novel coronavirus. The outcomes of the ARDL approach failed to find evidence towards the impact of Chinese COVID-19 records on the Romanian financial market, neither in the short-term, nor in the long-term.
On the other hand, our quantitative approach reveals a negative effect of the new deaths' cases from Italy on the 10-year Romanian bond yield both in the short-run and long-run. The econometric research provide evidence that Romanian 10-year government bond
is more sensitive to the news related to COVID-19 than the index of the Bucharest Stock Exchange. Granger causality analysis reveals causal associations between selected stock market returns and Philadelphia Gold/Silver Index. |
|
|
Gibani, MalickM, Toumazou, et al |
The Lancet Microbe |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Laboratory RT-PCR testing is the current standard of care but usually requires a centralised laboratory and significant
infrastructure. We describe our diagnostic accuracy assessment of a novel, rapid point-of-care real time RT-PCR CovidNudge test, which requires no laboratory handling or sample pre-processing. |
|
|
Gilbert, RE, Caldwell, et al |
Canadian Journal of Diabetes |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We hypothesized that the renal abundance of angiotensin-converting enzyme (ACE) 2, the cell surface receptor for SARS-CoV-2,
may be modulated by diabetes and agents that block the renin-angiotensin-aldosterone system (RAAS). The expression of ACE 2 was examined in 49 archival kidney biopsies from patients with diabetic kidney disease and from 12 healthy, potential living allograft
donors using next-generation sequencing technology (RNA Seq). Mean ACE 2 messenger RNA was increased approximately 2-fold in diabetes when compared with healthy control subjects (mean ± SD, 13.2 ± 7.9 vs 7.7 ± 3.6 reads per million reads, respectively; p =
0.001). No difference in transcript abundance was noted between recipients and nonrecipients of agents that block the RAAS (12.2 ± 6.7 vs 16.2 ± 10.7 reads per million reads, respectively; p = 0.25). |
|
|
Girma, S, Alenko, et al |
Risk Management and Healthcare Policy |
Healthcare Response | Réponse des soins de santé |
This study was designed to determine knowledge and precautionary behavior practice for COVID-19 among health professionals
working in public university hospitals in Ethiopia. A total of 273 health professionals participated in this study. The mean (± SD) age of participants was 31.03 ± 5.11. Two-third (61.5%) and one-fourth (26%) of participants attended second degree and medical
doctors, respectively. More than one-fourth of the study participants (27.5%) reported social media as the source of information. In this study, we found a significant gap between the level of knowledge and practical implementation of the recommended precautionary
measures, especially for wearing masks and gloves. The final multiple linear regression analysis indicated a positive association between knowledge of the source of infection, incubation period, and mode of disease transmission with recommended behavioral
practice. |
|
|
Ischemic colitis and short bowel disease due to
choronavirus disease 2019 (COVID 19) |
González Lázaro, P, Lomas Meneses, et al |
Clinical Nutrition ESPEN |
Clinical data| Données cliniques |
We would like to report a case of a 53 year old man with medical history of type 2 diabetes, and hypercholesterolemia,
with ishchemic colitis as first manifestation of infection of COVID 19. |
|
Gonzalez-Fernandez, O, Ponz de Antonio, et al |
Revista espanola de cardiologia |
Clinical data| Données cliniques |
Article in Spanish. The objective of this study is to analyze echocardiographic abnormalities and biomarkers in patients
with COVID-19 who require intensive care and their association with survival at 30 days. It is a prospective and observational cohort study of patients admitted to the care unit Intensive Care Units (ICU) at Hospital Universitario La Paz (Madrid, Spain) with
confirmed COVID-19 infection and acute respiratory distress syndrome between March 1 and April 8, 2020. |
|
|
Gouttebarge, V, Ahmad, et al |
Clin J Sport Med |
Public Health response| Interventions de santé publique |
The primary objective of our cross-sectional study was to establish the prevalence of anxiety and depressive symptoms
among professional football (ie, soccer; hereinafter "football") players during the COVID-19 emergency period, drawing comparisons with players assessed before exposure to the COVID-19 emergency period. A total of 468 female (mean age: 22.8 years) and 1134
male (mean age: 26.0 years) players participated. The non-COVID-19 comparison group consisted of 132 female (mean age: 23.1 years) and 175 male (mean age: 24.8 years) professional footballers. During the COVID-19 emergency period, the 2-week prevalence of
symptoms consistent with a diagnosis of generalized anxiety disorder and depression was 18.2% and 21.6%, respectively, among female professional footballers and 15.5% and 12.9%, respectively, among male players. The 2-week prevalence of anxiety and depressive
symptoms among professional footballers was significantly higher during the COVID-19 emergency period than before the global pandemic (P < 0.01). Differences were most pronounced for those worried about the playing future. |
|
|
Rebound of Severe Alcoholic Intoxications in Adolescents and Young Adults
After COVID-19 Lockdown |
Grigoletto, V, Cognigni, et al |
J Adolesc Health |
Healthcare Response | Réponse des soins de santé |
To date, little evidence is available about the effect of lockdown release in terms of adolescent health from the perspective
of an emergency department (ED). We reviewed data on ED arrivals of adolescents and young adults (aged 13-24 years) in the weeks immediately before and after the Italian lockdown release in 2020, and in the same periods in 2019, with a focus on cases of severe
alcohol abuse, psychomotor agitation, and other mental issues. The relative frequency of severe alcohol intoxications increased from .88% during the last part of the lockdown to 11.3% after lockdown release. When comparing these data with the same period in
2019, a highly significant difference emerged, with severe alcohol intoxications accounting for 11.31% of ED visits versus 2.96%, respectively. The relative frequency of ED arrivals related to psychomotor agitation or other mental health issues was not significantly
increased after lockdown release. |
|
Gupta, MD, Qamar, et al |
Indian Pacing and Electrophysiology Journal |
Clinical data| Données cliniques |
In the present case series of bradyarrhythmia in patients with COVID-19, we report complete heart block requiring intervention
in 5 patients and sinus node dysfunction in 2 patients. |
|
|
Gupta, R, Gant, et al |
International Journal of Infectious Diseases |
Clinical data| Données cliniques Immunology | Immunologie |
The reasons why some patients with COVID-19 develop pneumonia and others do not are unclear. To better understand this,
we used multiparameter flow cytometry to profile circulating leukocytes from non-immunocompromised adult patients with PCR-proven COVID-19 and specifically compared those with mild symptoms with those who had developed pneumonia. We observed striking and unexpected
differences in cells of the innate immune system. Levels of CD11b and CD18, which together comprise Complement Receptor 3 (CR3), were increased in granulocytes and monocytes from hypoxic COVID-19 patients, but not in those with COVID-19 who remained well,
or in those without COVID-19 but ventilated for other reasons. Granulocyte and monocyte numbers were unchanged, however Natural Killer (NK) cell numbers were two-fold higher than normal in COVID-19 patients who remained well. |
|
|
Assessment
of preventive measures application against covid-19 in the workplace |
Hamadouche, M, Allouche, et al |
Tunisie Medicale |
Public Health response| Interventions de santé publique |
Evaluate the preventive measures taken by the service sector companies against the spread of the virus. A high prevalence
(42%) of women put on leave was found. Physical meetings were held in 38% of the companies, hydroalcoholic solution was available for employees in 85% and for customers only in 4%. In more than 70% of cases, disinfection of surfaces, floors and door handles
took place frequently. Safety distance between employees and customers was respected in 88%, between employees in 66% and between customers in 63% of the companies. The wearing of a mask by all, the majority, some and none of the employees was observed in
respectively 15%, 17%, 39% and 29% of the companies. |
|
Hamzavi, SS, Gholami, et al |
Archives of Iranian medicine |
Clinical data| Données cliniques |
Report a case of COVID-19 infection in a child presenting with respiratory distress and pleural effusion. |
|
|
Han, X, Xia, et al |
Am J Phys Med Rehabil |
Clinical data| Données cliniques |
We retrospectively analyzed the infection features of inpatients with brain damage (BD) in one rehabilitation ward
of a large general hospital with natural exposure to COVID-19 at the beginning of the outbreak in Wuhan. We analyzed the demographic characteristics, major injuries, comorbidities, dysfunctions, and daily activity levels of COVID-19 patients with BD from this
ward and further explored the differences between these patients and noninfected subjects with BD. BD inpatients with impaired airways and low activity levels are more susceptible to COVID-19 and can easily become severely ill or even die. |
|
|
Han, Y, Wang, et al |
Brief Bioinform |
Therapeutics| Thérapeutique |
In this study, we use the ligand-protein docking program and molecular dynamic simulation to ab initio investigate
the binding mechanism and inhibitory ability of seven clinically approved drugs (Chloroquine, Hydroxychloroquine, Remdesivir, Ritonavir, Beclabuvir, Indinavir and Favipiravir) and a recently designed α-ketoamide inhibitor (13b) at the molecular level. The
results suggest that Chloroquine has the strongest binding affinity with 3CL hydrolase (Mpro) among clinically approved drugs, indicating its effective inhibitory ability for SARS-CoV-2. However, the newly designed inhibitor 13b shows potentially improved
inhibition efficiency with larger binding energy compared with Chloroquine. |
|
|
Psychosocial burdens of a renal transplant recipient with COVID-19 |
Haokip, N, Rathore, et al |
Indian Journal of Palliative Care |
Clinical data| Données cliniques |
Discuss a case of a 40-year-old male who received kidney transplantation 2 years ago and has tested positive for COVID-19. |
|
Hassen, LM, Almaghlouth, et al |
Int J Rheum Dis |
Healthcare Response | Réponse des soins de santé |
This cross-sectional study aims to examine Rheumatic patients' experiences during the current pandemic and its implication
on their health perception and behavior. Patients' knowledge about COVID-19 was correlated with social media use. Fear of COVID-19 infection correlated with healthcare facility for follow-up visits and fear of disease deterioration if contracting the infection
correlated with patients' levels of knowledge. Both types of fear did not correlate with patients' perceptions of disease activity. However, patients' perceptions of worsened disease activity were correlated with unplanned healthcare visits, medication non-adherence,
and difficulty accessing medication. |
|
|
He, F, Quan, et al |
Aging and Disease |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aims to describe clinical characteristics and determine risk factors for intensive care unit (ICU) admission
of COVID-19 patients with CVD. In this retrospective cohort study, we included 288 adult patients with COVID-19 in Guangzhou Eighth People's Hospital from January 15, 2020 to March 10, 2020. Multivariate regression analysis showed that the following were risk
factors for ICU admission in COVID-19 patients with CVD: Older age, CRP greater than 10 mg/L, TnI higher than 0.03 μg/L, and respiratory rate over 24 times per minute . |
|
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A New Era of Epidemiology: Digital Epidemiology for Investigating the COVID-19 Outbreak in China |
He, Z, Zhang, et al |
J Med Internet Res |
Epidemiology| Épidémiologie Public Health Priorities| Priorités de santé publique |
Available multidimensional social network data that take advantage of the recent rapid development of information and
communication technologies allow for an exploration of disease spread and control via a modernized epidemiological approach. By using spatiotemporal data and real-time information, we can provide more accurate estimates of disease spread patterns related to
human activities and enable more efficient responses to the outbreak. Two real cases during the COVID-19 outbreak demonstrated the application of emerging technologies and digital data in monitoring human movements related to disease spread. Although the ethical
issues related to using digital epidemiology are still under debate, the cases reported in this article may enable the identification of more effective public health measures, as well as future applications of such digitally directed epidemiological approaches
in controlling infectious disease outbreaks. |
|
Discovery of human ACE2 variants with altered recognition
by the SARS-CoV-2 spike protein |
Heinzelman, Pete, Romero, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Understanding how human ACE2 genetic variants differ in their recognition by SARS-CoV-2 can have a major impact in
leveraging ACE2 as an axis for treating and preventing COVID-19. In this work, we experimentally interrogate thousands of ACE2 mutants to identify over one hundred human single-nucleotide variants (SNVs) that are likely to have altered recognition by the virus,
and make the complementary discovery that ACE2 residues distant from the spike interface can have a strong influence upon the ACE2-spike interaction. These findings illuminate new links between ACE2 sequence and spike recognition, and will find wide-ranging
utility in SARS-CoV-2 fundamental research, epidemiological analyses, and clinical trial design. |
|
Hermann, M, Pekacka-Egli, et al |
Am J Phys Med Rehabil |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We retrospectively analyzed a cohort of COVID-19 patients in a single-center inpatient rehabilitation clinic and describe
performance and outcome during cardiopulmonary rehabilitation.Patients were referred from acute care hospitals for rehabilitation after severe COVID-19. The cohort (N = 28) was divided in ventilated or not ventilated patients for further analysis. Fifty percent
were female, the mean age was 66 yrs, and patients stayed in the acute hospital for 19.3 ± 10.7 days before referral for cardiopulmonary rehabilitation. Seventeen patients (61%) needed previous intensive care unit treatment in the acute care hospital. Significant
enhancements were observed in 6-min walking test and feeling thermometer, which were independent of previous ventilation status .In conclusion, comprehensive cardiopulmonary rehabilitation after COVID-19 is safe, feasible, and effective. Improvements in physical
performance and subjective health status were independent of previous ventilation. |
|
|
Higazy, M, Alyami, et al |
Alexandria Engineering Journal |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission |
Fractional derivative has a memory and non-localization features that make it very useful in modelling epidemics’ transition.
The kernel of Caputo-Fabrizio fractional derivative has many features such as non-singularity, non-locality and an exponential form. Therefore, it is preferred for modeling disease spreading systems. In this work, we suggest to formulate COVID-19 epidemic
transmission via SEIASqEqHR paradigm using the Caputo-Fabrizio fractional derivation method. In the suggested fractional order COVID-19 SEIASqEqHR paradigm, the impact of changing quarantining and contact rates are examined. The stability of the proposed fractional
order COVID-19 SEIASqEqHR paradigm is studied and a parametric rule for the fundamental reproduction number formula is given. The existence and uniqueness of stable solution of the proposed fractional order COVID-19 SEIASqEqHR paradigm are proved. Since the
genetic algorithm is a common powerful optimization method, we propose an optimum control strategy based on the genetic algorithm. By this strategy, the peak values of the infected population classes are to be minimized. The results show that the proposed
fractional model is epidemiologically well-posed and is a proper elect. |
|
|
Hino, T, Hata, et al |
European Journal of Radiology Open |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We investigate the correlation of the projected lung area (PLA) by dynamic chest X-ray with pulmonary functions. The
PLAs have correlation with physical characteristics, including height, weight and BMI, and pulmonary functions such as vital capacity (VC) and forced expiratory volume in one second (FEV1). Our results indicate DXR has a possibility to serve as an alternate
method for pulmonary function tests in subjects requiring contact inhibition including patients with suspected or confirmed covid-19. |
|
|
Hirotsu, Y, Maejima, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques Diagnostics / Pathogen
detection| Diagnostics / Détection d'agents pathogènes |
We assess the performance of the LUMIPULSE antigen test compared to RT-qPCR. The antigen level was significantly higher
in PCR-positive samples than in negative samples. In specimens with > 100 viral copies and between 10 and 100 copies, the antigen test showed 100% and 85% concordance with RT-qPCR, respectively. This concordance declined with lower viral loads. In the serially
followed patients, the antigen levels showed a steady decline, along with viral clearance. |
|
|
Mental Distress in the United States at the Beginning of the COVID-19 Pandemic |
Holingue, C, Kalb, et al |
Am J Public Health |
Public Health response| Interventions de santé publique |
We aim to assess the impact of the COVID-19 pandemic on mental distress in US adults. Among states with 50 or more
COVID-19 cases as of March 10, each additional day was significantly associated with an 11% increase in the odds of moving up a category of distress (odds ratio = 1.11; 95% confidence interval = 1.01, 1.21; P = .02). Perceptions about the likelihood of getting
infected, death from the virus, and steps taken to avoid infecting others were associated with increased mental distress in the model that included all states. |
|
Holter, JC, Pischke, et al |
Proc Natl Acad Sci U S A |
Clinical data| Données cliniques Immunology | Immunologie |
This study shows that a number of complement activation products are systemically, consistently, and long-lastingly
increased from admission and during the hospital stay. Notably, the terminal sC5b-9 complement complex was associated with respiratory failure. Thus, complement inhibition is an attractive therapeutic approach for treatment of COVD-19. |
|
|
Hong, R, Zhao, et al |
Bone Marrow Transplant |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
This retrospective study evaluated the clinical characteristics of severe cytokine release syndrome (CRS) (sCRS, grade
3–4) induced by severe COVID-19 (40 patients) or chimeric antigen receptor T-cell (CAR-T) therapy as a comparator (41 patients). Grade 4 CRS was significantly more common in the COVID-19 group (15/40 (35.7%) vs. 5/41 (12.2%), P = 0.008). Our study demonstrated
that there were similar processes but different intensity of inflammatory responses of sCRS in COVID-19 and CAR-T group. |
|
|
Hooijberg, F, Boekel, et al |
The Lancet Rheumatology |
Public Health response| Interventions de santé publique |
In this study, we compared the isolation measures taken by patients with rheumatic disease and healthy participants. |
|
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Europe’s war against covid-19: A map of countries’ disease vulnerability using mortality
indicators |
Horobet, A, Simionescu, et al |
International Journal of Environmental Research and Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public Health
Priorities| Priorités de santé publique |
We matched COVID-19 comorbidities with causes of death in 28 EU countries for the total population and for the population
above 65 years and applied a machine-learning-based tree clustering algorithm on shares of death for COVID-19 comorbidities and for influenza and on their growth rates between 2011 and 2016. We distributed EU countries in clusters and drew a map of the EU
populations’ vulnerabilities to COVID-19 comorbidities and to influenza. The heat maps of EU populations’ vulnerability to diseases based on mortality indicators constitute the basis for more targeted health policy strategies in a collaborative effort at the
EU level. |
|
Hosseini, S, Bahrevar, et al |
Pakistan Journal of Medical and Health Sciences |
Public Health response| Interventions de santé publique |
We investigate the fear of coronavirus spreading and the feeling created after seeing a foreign tourist in Yazd is
located in the center of Iran. The results of this study showed that fear of COVID-19 among people had been doubled after the official report of the first case of Iran. Meanwhile, the fear due to seeing foreign tourists had been higher in after start epidemic
in IR than before start epidemic. Therefore, it is recommended that educational and prevention programs should be developed to control fear in individuals. |
|
|
Therapeutic Plasma Exchange Therapy Support for Critical COVID-19: A Case Report |
Hua, T, Ming, et al |
Ther Apher Dial |
Clinical data| Données cliniques |
Case report of a 67-year-old man, with a medical history of chronic obstructive pulmonary disease, hypertension,
and diabetes, presented to the hospital with a one-week history of cough, fatigue, sputum with fever. SARS-CoV-2 test was positive. |
|
Huang, Q, Li, et al |
European Journal of Radiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We qualitatively and quantitatively assess kidney impairment in adults with COVID-19 by analysing imaging features
on non-enhanced CT (NECT) and possible correlation between renal parenchymal attenuation (RPA) and serum creatinine (SCr) levels on admission. RPA measurements and PFS could be useful in quantitative and qualitative evaluation of COVID-19 associated renal
impairment on admission. |
|
|
Transient Global Amnesia as a Possible First Manifestation of COVID-19 |
Hussein, HM |
Neurohospitalist |
Clinical data| Données cliniques |
We describe a case of a 53-year-old man presented with classic syndrome of transient global amnesia with symptoms lasting
less than 24 hours and mild transient unexplained fever. The day after discharge, the patient started to experience the classic respiratory and systemic COVID-19 illness and was eventually readmitted with hypoxic respiratory failure and positive COVID-19 test
a week after the first hospital discharge. |
|
N95 masks can be recycled:
One hour at 70°C kills SARS-CoV-2 |
Huwa, R |
Deutsche Apotheker Zeitung |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Full article not available |
|
Identification of novel antiviral drug combinations
in vitro and tracking their development |
Ianevski, Aleksandr, Yao, et al |
bioRxiv |
Therapeutics| Thérapeutique |
Here, we identify several new synergistic combinations against emerging and re-emerging viral infections in vitro.
We observed synergistic activity of nelfinavir with |
|
32771381; Use of remdesivir for pregnant patients with severe novel coronavirus
disease 2019 |
Igbinosa, I, Miller, et al |
American Journal of Obstetrics and Gynecology |
Clinical data| Données cliniques |
Here, we briefly describe the treatment of 3 pregnant patients hospitalized at our institution with confirmed severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and imaging supportive of lower respiratory disease, who met the criteria for compassionate use protocol of remdesivir. |
|
Ivanova, M, Ivanov, et al |
Anatolia |
Public Health response| Interventions de santé publique |
The paper analyses the travel intentions of tourists in the post-pandemic world. The sample includes 974 respondents
from Bulgaria. The findings show that most of the respondents are ready to travel within 2 months after travel is allowed in the country. |
|
|
Jafarzadeh-Esfehani, R, Mirzaei Fard, et al |
Archives of Iranian medicine |
Healthcare Response | Réponse des soins de santé |
The medical staff in endemic areas are becoming exhausted and deal with a considerable level of job burnout, which
can negatively affect their medical decision making. Also, due to the variable pulmonary manifestations of COVID-19, some physicians may misdiagnose patients. To overcome these issues, we proposed a web-based software to aid physicians in detecting possible
COVID-19 cases through online consultation with different specialists and educate the not-well experienced physicians. Our results demonstrated that this software could improve the diagnostic rate for not-well experienced physicians. |
|
|
PMC7476608; A deep learning approach to detect Covid-19 coronavirus with X-Ray images |
Jain, G, Mittal, et al |
Biocybern Biomed Eng |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Rapid and accurate detection of COVID-19 coronavirus is necessity of time to prevent and control of this pandemic by
timely quarantine and medical treatment in absence of any vaccine. Comprehensive evaluations have been performed to demonstrate the effectiveness of the proposed method with both (i) training-validation-testing and (ii) 5-fold cross validation procedures.
High classification accuracy as 97.77%, recall as 97.14% and precision as 97.14% in case of COVID-19 detection shows the efficacy of proposed method in present need of time. |
|
Jamshidiantehrani, M, Ahmadzadeh, et al |
Systematic Reviews in Pharmacy |
Economics | Économie |
The aim of this study is to identify, rank, and determine the importance of factors influencing the agility of pharmaceutical
company in COVID-19 pandemic using Multi-Criteria Decision-Making Methods. |
|
|
Transportation Activity Patterns of Chinese Population during the COVID-19
Epidemic |
Jiang, N, Li, et al |
Research of Environmental Sciences |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
In order to understand the frequency and transportation of people during the outbreak of the new coronavirus pneumonia
(COVID-19) in China, the survey collected 31 provinces (autonomous regions and municipalities) in China from February 25 to March 14, 2020. The travel frequency and transportation modes of the 8330 residents during the epidemic period were analyzed, and their
influencing factors were analyzed. |
|
Psychological impact of COVID-19 confinement and its relationship with meditation |
Jiménez, Ó, Sánchez-Sánchez, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
The objective of this study was to evaluate the psychological impact of confinement due to the COVID-19 pandemic, considering
any protective factors, such as the practice of meditation or self-compassion, and their relationship with different lifestyles and circumstances of adults residing in Spain. |
|
Political Consequences of COVID-19 and Media Framing in South Korea |
Jo, W, Chang, et al |
Frontiers in Public Health |
Public Health Priorities| Priorités de santé publique |
This study explored the Korean media's framing of COVID-19 and its impact on people's support for the government. Based
on our analysis results, we argue that expanded framing, which compared the quarantine performance of Korea and other countries, induced a positive change in people's attitudes toward the government, leading to a major political victory for the ruling party
in the legislative election. |
|
Jolly, TS, Batchelder, et al |
Prim Care Companion CNS Disord |
Clinical data| Données cliniques Public Health response| Interventions de santé publique |
Much is unknown regarding the long-term mental health impacts of an infectious disease pandemic of this magnitude on
children and adolescents. We present a case series of adolescents who were admitted to an inpatient psychiatric facility with mental health crisis and safety concerns due to COVID-19–related stress. |
|
|
Kada, D, Labzai, et al |
Journal of Mathematical and Computational Science |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
We study the transmission of (COVID-19) in the human population. We use the compartments model to describe the spread
of this infectious disease. We propose a discrete mathematical model with control strategies using three variables of controls u, v and w that represent respectively: Urging people to wash their hands with water and soap, cleaning and disinfecting surfaces
frequently, urging people to use masks to cover the sensitive body parts and the treatment of patients infected with (COVID-19) by taking them to hospitals and quarantine sites. |
|
|
Disaster
management strategies for coping with covid-19 pandemic in India |
Kala, CP |
Studies on Ethno-Medicine |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique
Public Health Priorities| Priorités de santé publique |
The present study indicates that only 0.012 percent of India’s population was infected by May 30, 2020, which was quite
lower than the expected one. The percentage of lethality rate was also low in India in comparison to the developed nations. It was anticipated in the beginning that the COVID-19 will be weakened with rising temperature in the summer or in the warm climate.
In India, the COVID-19 spread was noticed all over the country from warm (southern) to cold regions (northern), and no relationship was observed between the warm climate and the low occurrence of COVID-19. The study discusses various strategies as taken up
by the Government of India to reduce the risks and the adverse impacts of the pandemic. |
|
Kanchana, A, Varuvel, et al |
International Journal of Pharmaceutical Research |
Clinical data| Données cliniques |
Although a remedy for COVID-19 has not yet been found, the symptoms caused were identified. With the help of this information,
the main factor causing COVID-19 has been found using Fuzzy Cognitive Map. |
|
|
The lived experience of nurses caring for patients with COVID-19 in iran: A phenomenological
study |
Karimi, Z, Fereidouni, et al |
Risk Management and Healthcare Policy |
Healthcare Response | Réponse des soins de santé |
This study aimed to explore the lived experiences of nurses caring for patients with COVID-19 in Iran. The results
of this study show that nurses working in the wards and care centres designated for patients with COVID-19 are experiencing mental and emotional distress and are working in inadequate professional conditions. |
|
Karthik, A, Rustagi, et al |
Indian Journal of Palliative Care |
Healthcare Response | Réponse des soins de santé |
The lockdown has prevented patients in India from approaching hospitals. The single-day average of out-patients, in-patients,
and other department consultation requests requiring palliative care decreased drastically during the lockdown in comparison to the previous year. The single-day average of teleconsultations increased more than double during the lockdown. Various steps have
to be adopted in the regular working pattern of hospitals to cater to the needs of the patients requiring care, without increasing the risk of contracting COVID-19. |
|
|
Kashyap, A, Raghuvanshi, et al |
Management Research |
Public health interventions*| Interventions de santé publique Economics | Économie |
The purpose of this study is to suggest a strategy which balances both preventive measures and economic losses to control
the pandemic. |
|
|
Kassaw, C |
Psychology Research and Behavior Management |
Public Health response| Interventions de santé publique |
This study aimed to determine the magnitude of psychological problems and associated factors among communities living
in Addis Ababa, Ethiopia. At the time of the initial COVID-19 pandemic in Ethiopia, nearly two-thirds of the respondents reported moderate to severe levels of psychological problems. |
|
|
SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels |
Kaufman, HW, Niles, et al |
PLoS One |
Epidemiology| Épidémiologie |
This study used a retrospective, observational analysis of deidentified tests performed at a national clinical laboratory
to determine if circulating 25-hydroxyvitamin D (25(OH)D) levels are associated with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) positivity rates. cThis study used a retrospective, observational analysis of deidentified tests performed at a
national clinical laboratory to determine if circulating 25-hydroxyvitamin D (25(OH)D) levels are associated with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) positivity rates. |
|
Keita, A, Bacharou, et al |
Pan African Medical Journal |
Clinical data| Données cliniques |
The patients presented to the ENT Department where they received no therapy and underwent outpatient surveillance.
After 5 weeks, patients reported they had recovered the sense of smell. This study highlights that anosmia can occur without aguesia and persist after healing in COVID-19 patients. |
|
|
Kent, K, Murray, et al |
Nutrients |
Public Health response| Interventions de santé publique |
This study aims to describe the prevalence and socio-demographic associations of food insecurity in Tasmania, Australia,
during the COVID-19 pandemic. Our results suggest that the prevalence of food insecurity may have increased during the COVID-19 pandemic, particularly among economically vulnerable households and people who lost income. |
|
|
Kerget, B, Akgun, et al |
Eurasian Journal of Medicine |
Clinical data| Données cliniques |
Coronavirus disease (COVID-19) emerged in Wuhan, China, in December 2019 and rapidly became a global pandemic, with
the number of confirmed infections worldwide reaching 1 million by the start of April 2020 and 3 million less than a month later. COVID-19 can be encountered with different clinical presentations. We present the case of a patient with COVID-19 in the etiology
presenting with acute renal failure. © 2020, AVES. All rights reserved. |
|
|
Kern, PM, Müller, et al |
Klinikarzt |
Epidemiology| Épidémiologie Immunology | Immunologie |
In a hospital with maximum care, 74.8% of all employees with direct patient contact (n = 1480) and, as a non-medical
professional control group, employees of local supermarkets with direct customer contact (n = 300) were tested for antibodies of the IgA and IgG classes against SARS-CoV-2 tested.1.0% of the test persons were positive for IgG, 4.4% for IgA. With a test specificity
of 99.6% (IgG) or 92.4% (IgA), there is no clinically significant immunity to SARS-CoV-2 in either the total test collective or in any of the subgroups. |
|
|
Khan, H, Khan, et al |
Anaesthesia, Pain and Intensive Care |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to have risk factors stratification, prevalent symptoms at the time of presentation to the hospital and to
determine factors contributing to mortality due to COVID-19 in population of Nowshera (Pakistan). Out of a total of 75 patients, 20 (26.67%) were females and 55 (73.33%) were males. The mean age was 36±18 y. Out of these, 29 (38.67%) patients were COVID-19
positive by PCR technique, and 46 (61.33%) were negative. The probability of virus detection was higher in male gender (OR = 1.5, Relative Risk (RR) = 1.2). A significant relation of viral infectivity was noted with history of travel to an epidemic area (p
= 0.01 OR = 3.85, RR = 1.5) and history of contacts with COVID-19 infected person/s (p = 0.018, OR = 3. 5, RR = 2.3). A high mortality rate of 3/29 (10.34%) for positive COVID-19 cases was recorded. The probability of worse outcome in term of death in COVID-19
positive patients was (p = 0.5, OR = 2.1). Regarding symptoms selection; contact and travel history without any symptoms has a reliability index (RI) of 12/35 (34%) for infectivity. Cough, fever with shortness of breath (RI; 8/12(67%) for positive cases followed
by fever and cough with RI of 6/10 (60%) cases etc. Sore throat (RI; 1/13(8%) and flue only (RI;0/3(0%) proved non-reliable symptoms. When plotted the survival graphs of COVID positive vs. COVID negative cases, a similar pattern was recorded that showed the
mortality rate in the positive cases was not solely due to COVID-19, though being opportunistic infection, it would have contributed. We recorded refractory COVID-19 in 4/29 (13.79%) cases. |
|
|
A deep-learning-based framework for automated diagnosis of COVID-19 using X-ray images |
Khan, IU, Aslam, et al |
Information (Switzerland) |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this study, we used four deep-learning models-DenseNet121, ResNet50, VGG16, and VGG19-using the transfer-learning
concept for the diagnosis of X-ray images as COVID-19 or normal. In the proposed study, VGG16 and VGG19 outperformed the other two deep-learning models. The study achieved an overall classification accuracy of 99.3%. |
|
Kheirallah, KA, Alsinglawi, et al |
International Journal of Environmental Research and Public Health |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
This study simulated the trajectories of the COVID-19 pandemic curve in Jordan between February and May and assessed
the effect of Jordan’s strict NPI measures on the spread of COVID-19. The simulation model estimated the highest number of total daily new COVID-19 cases, in the pre-symptomatic compartmental state, to be 65 cases, with an epidemic curve growing to its peak
in 49 days and terminating in a duration of 83 days, and a total simulated cumulative case count of 1048 cases. The curve representing the number of actual reported cases in Jordan showed a good pattern compatibility to that in the mild and moderate to severe
compartmental states. The reproduction number under the non-pharmaceutical interventions (NPIs) was reduced from 5.6 to less than one. NPIs in Jordan seem to be effective in controlling the COVID-19 epidemic and reducing the reproduction rate. |
|
|
COVID 19: The New Normal in the Clinic: Overcoming Challenges in Palliative Care |
Khurana, D, Raheja, et al |
Indian Journal of Palliative Care |
Healthcare Response | Réponse des soins de santé |
This study analyzes the coping mechanisms of running outpatient and inpatient palliative care services in these COVID-19
times. Despite complete lockdown and initial low patient load, we saw a progressive increase in the number of patients coming to the clinic. A total of 108 patients visited our clinic (65 male and 43 female). Proper personal protection and social distancing
helped in preventing crossinfection. None of our staff or patients fell ill during this time. Communication skills were modified to convey feelings and empathize patients. Telemedicine using phone and video calls was used and found to be useful. |
|
Khurana, R, Varshney, et al |
Indian Journal of Palliative Care |
Healthcare Response | Réponse des soins de santé |
This study explored the trends in opioid dispensing for cancer pain before and during the lockdown. There was a decrease
in total morphine, tramadol, and fentanyl patch dispensing parallel to decrease in total number of patients visiting the outpatient department. However, there was a statistically significant increase in per capita opioid dispensing during the lockdown period.
There was also an increase in the proportion of cancer pain patients that were dispensed morphine during the lockdown. |
|
|
Khyar, O, Allali, et al |
Nonlinear Dynamics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper investigates the global stability analysis of two-strain epidemic model with two general incidence rates.
By constructing suitable Lyapunov functional, the global stability of the disease-free equilibrium is proved depending on the basic reproduction number R. |
|
|
Unsupervised Clustering of COVID-19 Chest X-Ray Images with a Self-Organizing
Feature Map |
King, B, Barve, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We applied chest x-ray images of COVID-19 patients to an Self-Organizing Feature Maps (SOFM)network and found a distinct
classification between sick and healthy patients with an average euclidean distance of 1.1 between 1st and 2nd winning neurons in our testing set. We were also able to show which features of the input space had the highest weight on the classification, to
study saliency of features on this unsupervised network. |
|
Topography, spike dynamics and nanomechanics of individual
native SARS-CoV-2 virions |
Kiss, Balint, Kis, et al |
bioRxiv |
Coronavirology| Coronavirologie |
By imaging and mechanically manipulating individual, native SARS-CoV-2 virions with atomic force microscopy, here we
show that their surface displays a dynamic brush owing to the flexibility and rapid motion of the spikes. The virions are highly compliant and able to recover from drastic mechanical perturbations. Their global structure is remarkably temperature resistant,
but the virion surface becomes progressively denuded of spikes upon thermal exposure. Thus, both the infectivity and thermal sensitivity of SARS-CoV-2 rely on the dynamics and the mechanics of the virus. |
|
Identification of misconceptions about corona outbreak using trigrams and weighted
TF-IDF model |
Kokatnoor, SA, Krishnan, et al |
Journal of Advanced Research in Dynamical and Control Systems |
Public Health response| Interventions de santé publique |
In this paper, the efficacy of Misconception Detection System was tested on Corona Pandemic Dataset extracted from
Twitter posts. A Trigram and a weighted TF-IDF Model followed by a supervised classifier were used for categorizing the dataset into two classes: one with misconceptions about COVID-19 virus and the other comprising correct and authenticated information. Trigrams
were more reliable as the functional words related to coronavirus appeared more frequently in the corpus created. The proposed system using a combination of trigrams and weighted TF-IDF gave relevant and a normalized score leading to an efficient creation
of vector space model and this has yielded good performance results when compared with traditional approaches using Bag of Words and Count Vectorizer technique where the vector space model was created only through word count. |
|
Koshi, E, Saito, et al |
CEN Case Rep |
Clinical data| Données cliniques |
The case involved a 52-year-old woman with COVID-19 who had been undergoing maintenance hemodialysis three times a
week for 3 years due to diabetic nephropathy. She had initially been treated with lopinavir/ritonavir and ciclesonide for 5 days, but developed severe pneumonia requiring invasive positive-pressure ventilation. Those antiviral agents were subsequently switched
to favipiravir. She recovered gradually, and after 2 weeks was extubated once the viral load of SARS-CoV-2 fell below the limit of detection. Although concentrations of several biliary enzymes were elevated, no major adverse events were observed. |
|
|
Krishnapriya, V, Rathore, et al |
Indian Journal of Palliative Care |
Clinical data| Données cliniques |
In this case, we discuss the concerns faced by a 37-year-old male with neuroendocrine tumor of the anal canal who was
tested COVID positive. His surgery was canceled following the report and was shifted to the COVID care facility. Best supportive care was given till further management. |
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Why i can't breastfeed my new-born baby? Psychosocial dilemma of a COVID-positive
post-LSCS mother |
Kumar, S, Rathore, et al |
Indian Journal of Palliative Care |
Clinical data| Données cliniques |
A 26-year-old postpartum COVID-positive mother admitted in COVID isolation facility at a tertiary care center in India.
Her primary physical concern was suture site pain and concerns related to expressed breast milk discarding. Her psychological concerns include distrust on COVID report, belief of unjust isolation, lack of family support, loneliness, feeling of not breast feeding
her baby, fear, anxiety, anger, stress, and depression. She was concerned about the stigma anticipated for herself and her baby. Spiritually, she was concerned as she was not able to make harmony between herself and environment. © 2020 Wolters Kluwer Medknow
Publications. All rights reserved. |
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Kumar, S, Rathore, et al |
Indian Journal of Palliative Care |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A retrospective study was conducted on 100 patients (73 males, 24 females, and 3 transgenders) admitted under institutional
isolation at a tertiary care center in India using a self-designed survey-based questionnaire. COVID incidence recorded is high in male (73%) as compared to female (24%), yet female patients have a higher prevalence of symptoms as compared to male patients. |
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Gynaecologic cancer care during COVID-19 pandemic in India: a social
media survey |
Kumari, S |
Cancer Rep (Hoboken) |
Healthcare Response | Réponse des soins de santé |
An anonymous survey consisting of 20 questions intended for the gynaecologic cancer care providers with emphasis on
their current practice and approach to their patients was distributed online via social media from April 30 to May 31, 2020. Among a total of 61 respondents, 63.9% were gynaecologic oncologists, 18.0% were radiation oncologists and 18.0% were medical oncologists.
Majority, that is, 95.1% health care professionals felt that COVID‐19 pandemic has had a significant change on their practice pattern and 56.2% practitioners had stopped registering new cases of cancer. |
|
Kurita, J, Sugawara, et al |
Journal of Infection and Chemotherapy |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
For this study, we estimated the basic reproduction number (R0) and schools (SC) and sport and entertainment events
(VEC) cancellation effects. The estimated R0 is similar to those found from other studies of China and Japan. Significant reduction of contact frequency has been achieved by SC and VEC. Nevertheless, its magnitude was insufficient to contain the outbreak. |
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Kwok, B, Brosnahan, et al |
Journal of thrombosis and thrombolysis |
Healthcare Response | Réponse des soins de santé |
This is a retrospective cohort study of all adult patients with acute PE who received care at an academic hospital
system in New York City between March 1st and April 30th, 2020. These patients were compared against historic controls between March 1st and April 30th, 2019. PE severity, Pulmonary Embolism Response Teams (PERT) utilization, initial management, PERT recommendations,
and outcomes were compared. There were more cases of PE during the pandemic (82 vs. 59), but less PERT activations (26.8% vs. 64.4%, p < 0.001) despite similar markers of PE severity. PERT recommendations were similar before and during the pandemic; anticoagulation
was most recommended (89.5% vs. 86.4%, p = 0.70). During the pandemic, those with PERT activations were more likely to be female (63.6% vs. 31.7%, p = 0.01), have a history of DVT/PE (22.7% vs. 1.7%, p = 0.01), and to be SARS-CoV-2 PCR negative (68.2% vs.
38.3% p = 0.02). PERT activation during the pandemic is associated with decreased length of stay (7.7 ± 7.7 vs. 13.2 ± 12.7 days, p = 0.02). PERT utilization decreased during the COVID-19 pandemic and its activation was associated with different biases. |
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Kyurkchiev, N, Iliev, et al |
lnternational Journal of Differential Equations and Applications |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We look at some comparisons between the Verhulst model and the new model (HLCGPVT), as well as the ability to approximate
specific population dynamics data, including "Data Corona Virus |
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A new diagnosis of systemic
capillary leak syndrome in a patient with COVID-19 |
Lacout, C, Rogez, et al |
Rheumatology (Oxford) |
Clinical data| Données cliniques |
Here we report the case of a 38-year-old male who presented a mild COVID-19 infection concomitantly with a first flare
of systemic capillary leak syndrome. |
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Investigation of SARS-CoV-2 outbreaks in six care homes in London, April 2020 |
Ladhani, SN, Chow, et al |
EClinicalMedicine |
Epidemiology| Épidémiologie Transmission |
We conducted detailed investigations in six London care homes reporting suspected COVID-19 outbreaks during April 2020.
Across the six care homes, 105/264 (39.8%) residents were SARS CoV-2 positive, including 28 (26.7%) symptomatic, 10 (9.5%) post-symptomatic, 21 (20.0%) pre-symptomatic and 46 (43.8%) who remained asymptomatic. Case-fatality at 14-day follow-up was highest
among symptomatic SARS-CoV-2 positive residents (10/28, 35.7%) compared to asymptomatic (2/4, 4.2%), post-symptomatic (2/10, 20.0%) or pre-symptomatic (3/21,14.3%) residents. Among staff, 53/254 (20.9%) were SARS-CoV-2 positive and 26/53 (49.1%) remained asymptomatic.
RT-PCR cycle-thresholds and live-virus recovery were similar between symptomatic/asymptomatic residents/staff. Higher RT-PCR cycle threshold values (lower virus load) samples were associated with exponentially decreasing ability to recover infectious virus
(P<0.001). WGS identified multiple (up to 9) separate introductions of different SARS-CoV-2 strains into individual care homes. |
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PMC7375183; The
Down Side of Prone Positioning: The Case of a Coronavirus 2019 Survivor |
Le, MQ, Rosales, et al |
Am J Phys Med Rehabil |
Clinical data| Données cliniques |
This case report describes the course and clinical findings of a survivor of acute respiratory distress syndrome due
to coronavirus 2019 who was prone positioned while in intensive care and subsequently admitted to an inpatient rehabilitation facility. Her related complications, as well as those described in the literature, are reviewed. |
|
Lee, LYW, Cazier, et al |
The Lancet Oncology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to investigate COVID-19 risk according to tumour subtype and patient demographics in patients
with cancer in the UK. 319 (30·6%) of 1044 patients in the UK Coronavirus Cancer Monitoring Project (UKCCMP)cohort died, 295 (92·5%) of whom had a cause of death recorded as due to COVID-19. The all-cause case–fatality rate in patients with cancer after SARS-CoV-2
infection was significantly associated with increasing age. Patients with haematological malignancies (leukaemia, lymphoma, and myeloma) had a more severe COVID-19 trajectory compared with patients with solid organ tumours. |
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Lee, PY, Platt, et al |
Journal of Allergy and Clinical Immunology |
Clinical data| Données cliniques |
We studied 2 unrelated patients with immune thrombocytopenia and autoimmune hemolytic anemia in the setting of acute
infections. Each patient was found to have a unique heterozygous truncation variant in suppressor of cytokine signaling 1 (SOCS1). Findings: Heterozygous loss-of-function SOCS1 mutations are associated with enhanced IFN signaling and increased immune cell
activation, thereby predisposing to infection-associated autoimmune cytopenias. |
|
|
Lee, Seung Won, Yang, et al |
The Lancet Psychiatry |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Between Jan 1 and May 15, 2020, 216 418 people were tested for SARS-CoV-2, of whom 7160 (3·3%) tested positive. In
the entire cohort with propensity score matching, 1391 (3·0%) of 47 058 patients without a mental illness tested positive for SARS-CoV-2, compared with 1383 (2·9%) of 48 058 with a mental illness (adjusted odds ratio [OR] 1·00, 95% CI 0·93–1·08). Among the
patients who tested positive for SARS-CoV-2, after propensity score matching, 109 (8·3%) of 1320 patients without a mental illness had severe clinical outcomes of COVID-19 compared with 128 (9·7%) of 1320 with a mental illness (adjusted OR 1·27, 95% CI 1·01–1·66). |
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|
Li, B |
Journal of Nippon Medical School |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Epidemiological exposures were investigated among patients reporting no travel to infected areas or direct contact
with a case-patient. Patients presented with various symptoms, increased levels of inflammatory markers, and consolidation or ground-glass opacification on computed tomography scans. |
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Management of catheter ablation in arrhythmia patients during the coronavirus
disease 2019 epidemic |
Li, K, Qin, et al |
ESC Heart Fail |
Healthcare Response | Réponse des soins de santé |
The present study attempted to explore the management of catheter ablation in arrhythmia patients during the pandemic.
By adopting strict risk assessments and careful infection prevention measures, catheter ablation in patients with arrhythmia can be safely and effectively performed during the COVID‐19 epidemic in well‐controlled areas. |
|
Li, S, Linton, et al |
Journal of Econometrics |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We carry out some analysis of the daily data on the number of new cases and the number of new deaths by (191) countries
as reported to the European Centre for Disease Prevention and Control (ECDC). Our benchmark model is a quadratic time trend model applied to the log of new cases for each country. We use our model to predict when the peak of the epidemic will arise in terms
of new cases or new deaths in each country and the peak level. We also predict how long the number of new daily cases in each country will fall by an order of magnitude. Finally, we also forecast the total number of cases and deaths for each country. We consider
two models that link the joint evolution of new cases and new deaths. © 2020 |
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Detection of SARS-CoV-2 in conjunctival secretions from patients
without ocular symptoms |
Li, X, Chan, et al |
Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A total of 158 conjunctival swabs were obtained from 49 laboratory-confirmed COVID-19 patients. Four conjunctival swabs
from four different patients (4/49, 8.2%) were positive for SARS-CoV-2 RNA by RT-PCR. |
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Associating COVID-19 Severity with Urban Factors: A Case Study of Wuhan |
Li, X, Zhou, et al |
Int J Environ Res Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Based on the Weibo help data, we inferred the spatial distribution pattern of the epidemic situation and its impacts.
A geographically weighted regression model (GWR) was adopted to identify their unevenly distributed effects in the urban space. The main findings were: (1)The distribution and density of major hospitals exert a positive association with the epidemic situation.
(2) The density of commercial facilities is the most prevalently distributed factor over the city that presents a positive association with the epidemic severity. (3) Newly developed residential quarters mainly distributed around the waterfront area of Hanyang
and Wuchang with high-rise buildings face greater risks. (4) The influence of subway stations concentrates at the adjacency place where the three towns meet and near-terminal locations. (5) The global regression model shows that the influence of land-use mixture
presents a significant association with the epidemic severity |
|
Li, ZH, Zhang, et al |
PLoS Negl Trop Dis |
Public Health response| Interventions de santé publique |
This study aimed to assess KAP regarding COVID-19 during the outbreak among workers in China. The present study was
part of a cross-sectional online survey study conducted based on a large labor-intensive factory, which has 180,000 workers from various Chinese provinces, from 2 February 2020 to 7 February 2020. A total of 123,768 valid responses (68.8%) were included
in the analysis. Generally, the levels of knowledge, attitudes, and practices related to COVID-19 were high. Only 36,373 respondents (29.4%) disagreed that gargling with salt water is effective in protecting against COVID-19. Moreover, older respondents had
decreased levels of knowledge and practices related to COVID-19, while better-educated respondents had increased levels of knowledge and practices related to COVID-19. |
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32873516; Olfactory Bulb Atrophy in a Case of COVID-19 with Hyposmia |
Liang, YC, Tsai, et al |
Academic Radiology |
Clinical data| Données cliniques |
Case report of a 16 year old female with COVID-19 |
|
Liang, Z, Wang, et al |
Research of Environmental Sciences |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The purpose of this paper is to explore the spatial heterogeneity of the relationship between the incidence of COVID-19
and population migration and socioeconomic factors in Chinese cities. Based on the geographically weighted regression (GWR) model, we analyzed the impact of the migration rate of all other cities across the country (MRall), migration rate of Wuhan (MRwuhan),
GDP per capita (GDPPC), green area per capita (GApc), number of medical staff per capita (NMSpc) and public expenditure per capita (PEpc) on the PRcovid in 282 cities in China. The results show that: (1) The explanatory power of GWR model on PRcovid was significantly
higher than that of ordinary least squares linear regression model. (2) The impact of MRwuhan decreased with increasing distance from Wuhan, except for parts of Northeast and Southwest China. (3) GDPpc played a positive role in controlling the PRcovid in the
more developed southeast region. (4) The indicators of GApc and NMSpc only effected positively in small parts of the country, excluding cities around Wuhan. In contrast, PEpc played a key role in controlling the PCcovid in the surrounding areas of Wuhan. In
conclusion, the incidence of COVID-19 in Chinese cities and its relationship with migration / urban socioeconomic indicators showed clear spatial patterns. |
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Patients’ perspective of telephone visits during the COVID-19 pandemic |
Locke, J, Herschorn, et al |
Canadian Urological Association Journal |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
We conducted a survey to evaluate patients’ perspective of telephone visits during the COVID-19 pandemic. Methods:
Patients receiving a scheduled telephone call, as a virtual visit, from urologists at our clinic were asked to participate in a three-minute, self-administered, online questionnaire. The outcomes evaluated were telephone visit satisfaction and preference for
type of appointment. Results: A total of 102 participants were included. 96% of participants assessed the telephone visit as a positive experience in every survey question, while 45% expressed no preference. In those who expressed a preference, this was
evenly divided between in-office visits and phone visits . |
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Covid-19 Risk Perception and Food Hoarding Intention: Evidence from Vietnam |
Long, NN, Khoi, et al |
Journal of Critical Reviews |
Public Health response| Interventions de santé publique |
This paper uses the expanded theory of planned behavior (TPB) model to evaluate risk perception and the intention to
hoard food during the COVID-19 pandemic in 2020. In this study, questionnaires were used to obtain information from respondents in order to conduct a quantitative investigation of COVID-19 risk perception and food hoarding intention. The responses of the respondents
to the surveys were the principal instrument for the collation of information and the primary tool to obtain data. The survey included questions regarding the determinants for the intention to hoard food during the COVID-19 pandemic. A total of 86 consumers
living in Ho Chi Minh City, Vietnam with the intention to hoard food were selected as the respondents. The data showed that higher risk perception was associated with a greater tendency toward hoard food. These findings indicate that high levels of risk perception,
such as during the COVID-19 pandemic or other periods of civil unrest, resulting in intentions to purchase goods that are no longer based on common sense. |
|
Lopez, AS, Hill, et al |
MMWR Morb Mortal Wkly Rep |
Transmission Clinical data| Données cliniques |
To better understand transmission from young children, contact tracing data collected from three COVID-19 outbreaks
in child care facilities in Salt Lake County, Utah, during April 1-July 10, 2020, were retrospectively reviewed to explore attack rates and transmission patterns. Twelve children acquired COVID-19 in child care facilities. Transmission was documented from
these children to at least 12 (26%) of 46 nonfacility contacts (confirmed or probable cases). One parent was hospitalized. Transmission was observed from two of three children with confirmed, asymptomatic COVID-19. Detailed contact tracing data show that children
can play a role in transmission from child care settings to household contacts. |
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López, EM, Medina, et al |
Revista Cubana de Pediatria |
Clinical data| Données cliniques |
Case series |
|
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Lu, J, Zhang, et al |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study explores the clinical characteristics and outcomes of adult critically ill patients with COVID-19 and identify
the risk factors correlated with in-hospital deaths. This study was conducted among 20 confirmed adult cases of COVID-19 in the Intensive Care Unit (ICU) of Honghu People’s Hospital in Jingzhou City, Hubei Province.
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Fast COVID-19 and pneumonia classification using chest X-ray images |
Luján-García, JE, Moreno-Ibarra, et al |
Mathematics |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The content of this article consists of a deep-learning model, specifically a convolutional neural network with pre-trained
weights, which allows us to use transfer learning to obtain new retrained models to classify COVID-19, pneumonia, and healthy patients. One of the main findings of this article is that the following relevant result was obtained in the dataset that we used
for the experiments: all the patients infected with SARS-CoV-2 and all the patients infected with pneumonia were correctly classified. These results allow us to conclude that the proposed method in this article may be useful to help physicians decide the diagnoses
related to COVID-19 and typical pneumonia. |
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Early mortality risk stratification after SARS-CoV-2 infection |
Lundon, DJ, Kelly, et al |
Medicina Intensiva |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Clinical
data| Données cliniques |
We developed a prediction model to identify those patients most likely to succumb to the disease thin 7 days (the median
time to death of those who died) from the onset of COVID-19 symptoms. We did this by first identifying all those whom died following a positive SARS-CoV-2 test, and all of those whom were positive for SARS-CoV-2, but surviving after at least 7 days post-diagnosis.
This model demonstrates the significant role that both clinical and social determinants play in predicting the clinical outcome for patients infected with SARS-CoV-2 and tested positive for COVID-19. |
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Obesity COVID-19 patients show more severe pneumonia lesions on CT chest imaging |
Luo, X, Jiaerken, et al |
Diabetes Obes Metab |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We evaluated the daily accumulation of lung lesions and calculated during which period pneumonia developed fastest
in obese patients, using AI-supported CT lesions quantification. We enrolled 231 patients with laboratory-confirmed COVID-19, who were admitted to 9 designated hospitals for treatment from 20 January to 11 March 2020. Conclusively, obese COVID-19 patients
had more diffuse pneumonia lesions than normal BMI patients, with lesions extending from inferior to superior lobes. |
|
Madsen, AMR, Schaltz-Buchholzer, et al |
Trials |
RCT |
We aim to test whether BCG vaccination may reduce susceptibility to and/or the severity of COVID-19 and other infectious
diseases in health care workers (HCW) and thus prevent work absenteeism.The primary objective is to reduce absenteeism due to illness among HCW during the COVID-19 pandemic. The secondary objectives are to reduce the number of HCW that are infected with SARS-CoV-2,
and to reduce the number of hospital admissions among HCW during the COVID-19 pandemic. |
|
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Single-cell RNA sequencing analysis of SARS-CoV-2 entry receptors in human organoids |
Mahalingam, R, Dharmalingam, et al |
J Cell Physiol |
Coronavirology| Coronavirologie |
Here, we used single-cell RNA sequencing data of human organoids to analyze expressions of ACE2 and TMPRSS2, in addition
to an array of RNA receptors to examine their role in SARS-CoV-2 pathogenesis. ACE2 is abundant in all organoids, except the prostate and brain, and TMPRSS2 is omnipresent. Innate immune pathways are upregulated in ACE2(+) cells of all organoids, except the
lungs. Besides this, the expression of low-density lipoprotein receptor is highly enriched in ACE2(+) cells in intestinal, lung, and retinal organoids, with the highest expression in lung organoids. Collectively, this study demonstrates that the organoids
can be used as an experimental platform to explore this novel virus disease mechanism and for drug development. |
|
Mahmood, S, Choudhary, et al |
Pakistan Journal of Medical and Health Sciences |
Healthcare Response | Réponse des soins de santé |
This cross-sectional study aimed to detect the psychological changes in doctors working in pediatrics, gynaecology,
medicine and surgery during COVID-19). A total of 240 doctors working in pediatrics, gynaecology, medicine or surgery were included from January 2020 to April 2020. Out of 240 doctors, 98(40.8%) were female doctors whereas 142(59.2%) were male doctors. Many
risk factors causing changes in mental health and behavior in doctors were detected including duty in hospital during corona crises, Social distance, Personnel protective equipment (PPE) use, fear of transmission of corona infection to their family members,
both electronic & social media and discussion in community. One doctor might be affected by multiple risk factors as well. Many unwanted changes in mental health and behavior in doctors were observed including changes in sleep, changes in appetite, anger,
difficulty in concentrating, fatigue and low energy, physical complaints like stomachaches etc not responding to normal treatment, feeling of hopelessness and increased sensitivity. |
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|
Maines, M, Zorzi, et al |
IJC Heart and Vasculature |
Healthcare Response | Réponse des soins de santé |
We aimed to report the short-term follow-up of 345 patients evaluated remotely and to compare it with a cohort of patients
evaluated in-person during the same period in 2019. During a mean follow-up of 54 ± 11 days, a significantly higher proportion of patients evaluated in-person in 2019 visited the emergency department or died for any cause (39/391, 10% versus 13/345 3.7%, p
= 0.001) and visited the emergency department for cardiovascular causes (19/391, 4.9% versus 7/345, 2.0%, p = 0.04) compared to 2020. No cardiovascular death was recorded in the two periods. To an evaluation with a satisfaction questionnaire 49% of patients
would like to continue using remote controls in addition to traditional ones. |
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Makrinioti, H, MacDonald, et al |
J Pediatric Infect Dis Soc |
Clinical data| Données cliniques |
We note that intussusception was likely associated with severe acute respiratory syndrome coronavirus-2 infection in
2 infants in Wuhan and London. The intussusception was reduced by enemas in Wuhan; the outcome was fatal. The intussusception was not reduced by enemas in London and required surgery; the outcome was favorable. |
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Malik, UR, Atif, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
A cross-sectional online survey involving physicians, pharmacists, and nurses was conducted. Out of 500 healthcare
professionals, 385 responded to the survey. The majority (70%) were aged 22–29 years; 144 (37.4%) physicians, 113 (29.4%) nurses, and 128 (33.2%) pharmacists completed the survey. Overall, 94.8% of healthcare professionals scored adequately (>14) for COVID-19-related
knowledge; 97.9% displayed an optimistic attitude (>42) and 94.5% had an adequate practice score (>28). Kruskal–Wallis and Jonckheere–Terpstra tests showed significant differences (p < 0.05) in KAP and risk assessment scores among groups; physicians and nurses
scored higher as compared to pharmacists. |
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Evaluation of Abbott anti-SARS-CoV-2 CMIA IgG and Euroimmun ELISA IgG/IgA assays
in a clinical lab |
Manalac, J, Yee, et al |
Clinica Chimica Acta |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We report our findings of test performance especially specificity of a fully automated Abbott Architect anti-SARS-CoV-2
CMIA IgG and Euroimmun anti-SARS-CoV-2 ELISA IgA/IgG in human plasma. We used positive cohort of 97 samples from Covid-19 patients or healthcare workers, collected at late time points from symptom onsets. We also included another cohort of 215 samples as negative
controls, 78 of which had positive serology test results of other infectious diseases or autoimmunity. Abbott IgG, Euroimmun IgG/IgA had high precision, demonstrated by both intra- and inter-day CVs of <2%. There was no Abbott or Euroimmun IgG assay cross
reactivity in the 78 samples with positive serology of non-SARS-CoV-2 infectious diseases and positive autoimmune antibodies. The Abbott IgG has specificity of 99.6%, while Euroimmun IgG and IgA were as high as 91.5% and 71.5%, respectively. |
|
Manes, G, Saibeni, et al |
Endoscopy |
Healthcare Response | Réponse des soins de santé |
We evaluated whether the pandemic has impacted the appropriateness and diagnostic yield of fast-track endoscopic procedures
in comparison with those performed in 2019. This retrospective survey has involved Endoscopic Services in Northern Italy; we compared data regarding endoscopic procedures performed in March and April 2020 with those performed in the same period in 2019. We
observed in 2020 a reduction of 53.6% in the number of procedures. Patients undergoing endoscopy in 2020 were younger than in 2019. Both appropriate referral and diagnostic yield increased in 2020 and it regarded both upper and lower endoscopy. A higher rate
of cancer was diagnosed in 2020 by upper endoscopy (3.6% vs 6.6%, p=0.04). |
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Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19 |
Mann, ER, Menon, et al |
Sci Immunol |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
We undertook longitudinal immune profiling on both whole blood and peripheral blood mononuclear cells (PBMCs) of hospitalized
patients during the peak of the COVID-19 pandemic in the UK. Here, we report key immune signatures present shortly after hospital admission that were associated with the severity of COVID-19. Immune signatures were related to shifts in neutrophil to T cell
ratio, elevated serum IL-6, MCP-1 and IP-10, and most strikingly, modulation of CD14(+) monocyte phenotype and function. Modified features of CD14(+) monocytes included poor induction of the prostaglandin-producing enzyme, COX-2, as well as enhanced expression
of the cell cycle marker K(i)-67. Longitudinal analysis revealed reversion of some immune features back to the healthy median level in patients with a good eventual outcome. |
|
Maor, Y, Cohen, et al |
EClinicalMedicine |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
In this prospective cohort study, we assessed outcome of patients with moderate and severe COVID-19 following treatment
with convalescent plasma (CP) and the association with IgG levels in transfused CP. Of 49 patients, 11 (22.4%) had moderate, 38 (77.6%) had severe disease, 28 were ventilated. At day 14, 24 (49.0%) patients improved, 9 (18.4%) died, and 13 (26.5%) were ventilated.
In 14/98 (14.3%) CP units IgG was 4.0 [OR 0.267 95% CI 0.079–0.905], P = 0.030. In patients diagnosed >10 days prior to treatment, 4/14 (22.4%) improved in the ≤4.0 antibody group, versus 6/7 (85.7%) in the >4.0 antibody group, OR 0.048 (95% CI, 0.004–0.520),
P = 0.007. No serious adverse events were reported. Treatment with CP with higher levels of IgG against S1 may benefit patients with moderate and severe COVID-19. IgG against S1 level in CP predicts neutralization antibodies titers. |
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Assessing the potential impact of COVID-19 on life expectancy |
Marois, G, Muttarak, et al |
PLoS One |
Public Health Priorities| Priorités de santé publique Public Health response| Interventions
de santé publique |
This paper provides first estimates of the potential direct impact of the COVID-19 pandemic on period life expectancy.
In regions with relatively high life expectancy, if the infection prevalence threshold exceeds 1 or 2%, the COVID-19 pandemic will break the secular trend of increasing life expectancy, resulting in a decline in period life expectancy. With life expectancy
being a key indicator of human development, mortality increase, especially among the vulnerable subgroups of populations, would set a country back on its path of human development. |
|
Marruzzo, G, Redi, et al |
European review for medical and pharmacological sciences |
Healthcare Response | Réponse des soins de santé |
The aim of our study is to analyze how the lockdown and its related sanitary policies affected post-bariatric patients’
behaviors towards the delay of their procedure. Data analysis showed that none of them encountered a decrease of the desire to be subjected to post-bariatric plastic surgery procedures, even though the waiting time increased. |
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Martínez-Sanz, J, Pérez-Molina, et al |
EClinicalMedicine |
Healthcare Response | Réponse des soins de santé |
We aim to identify the drivers of therapeutic aggressiveness during the first weeks of the COVID-19 pandemic. This
cross-sectional worldwide survey (conducted April 12 to 19, 2020) was aimed at physicians who managed patients diagnosed with COVID-19. The survey was completed by 852 physicians from 44 different specialties and 29 countries. The heterogeneity of therapeutic
decisions increased as the clinical scenario worsened. Factors associated with aggressive therapeutic decisions were higher self-perceived expertise (high vs. null, OR 1.95, 95%CI 1.31–2.89), perceived quality of COVID-19 publications (high vs. null, OR 1.92,
95%CI 1.17–3.16), and female sex (OR 1.17, 95%CI 1.02–1.33). Conversely, Infectious Diseases specialty, Latin American and North American origin, lower confidence in the treatments chosen, and having published articles indexed in PubMed as the first-author
were associated with the use of less aggressive therapies. |
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|
A rare case of acute motor axonal neuropathy and myelitis related to SARS-CoV-2
infection |
Masuccio, FG, Barra, et al |
J Neurol |
Clinical data| Données cliniques |
We describe a rare case of post-infective Acute Motor Axonal Neuropathy (AMAN) variant of Guillain-Barrè Syndrome (GBS)
associated with myelitis and anti-GD1b positivity after SARS-CoV-2 infection. |
|
A dynamic simulation study of FDA drug from zinc database against COVID-19 main
protease receptor |
Mathpal, S, Joshi, et al |
J Biomol Struct Dyn |
Therapeutics| Thérapeutique |
Our research aimed to identify the novel drugs for inhibition of Main protease (Mpro) enzyme of COVID-19 by performing
in silico approach. Out of seven compounds, four namely, ZINC03831201, ZINC08101052, ZINC01482077, and ZINC03830817 were found significant based on MD simulation results. Furthermore, RMSD, RMSF, RG, SASA, PCA, MMPBSA (for last 40 ns) were calculated for the
100 ns trajectory period. |
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Mattioli, AV, Ballerini Puviani, et al |
Journal of Arrhythmia |
Clinical data| Données cliniques |
The present case report highlights the usefulness of telemedicine during quarantine and isolation. The patient developed
a supraventricular arrhythmia, and the diagnosis and management of the arrhythmia was done online. This case report underlines the usefulness of a self‐monitoring friendly device in home evaluation. ButterfLife was used during a very stressful period of quarantine
in two elderly couples living by themselves. |
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McDonald, MV, Brickner, et al |
J Am Med Dir Assoc |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
This study aims to describe nurse hand hygiene practices in the home health care (HHC) setting, nurse adherence to
hand hygiene guidelines, and factors associated with hand hygiene opportunities during home care visits. The average hand hygiene adherence rate was 45.6% after adjusting for clustering at the nurse level. Adherence was highest after contact with body fluid
(65.1%) and lowest after touching a patient (29.5%). The number of hand hygiene opportunities was higher when patients being served were at increased risk of an infection-related emergency department visit or hospitalization and when the home environment was
observed to be “dirty.” No nurse or patient demographic characteristics were associated with the rate of nurse hand hygiene adherence. |
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Assessing the Impact of COVID-19 Public Health Stages on Paediatric Emergency Attendance |
McDonnell, T, Nicholson, et al |
Int J Environ Res Public Health |
Healthcare Response | Réponse des soins de santé |
This study outlines the impact of COVID-19 on paediatric emergency department (ED) utilisation and assesses the extent
of healthcare avoidance during each stage of the public health response strategy. Records from five EDs and one urgent care centre in Ireland, representing approximately 48% of national annual public paediatric ED attendances, are analysed to determine changes
in characteristics of attendance during the three month period following the first reported COVID-19 case in Ireland, with reference to specific national public health stages. ED attendance reduced by 27–62% across all categories of diagnosis in the Delay
phase and remained significantly below prior year levels as the country began Phase One of Reopening, with an incident rate ratio (IRR) of 0.58. The decrease was predominantly attributable to reduced attendance for injury and viral/viral induced conditions
resulting from changed living conditions imposed by the public health response. However, attendance for complex chronic conditions also reduced and had yet to return to pre-COVID levels as reopening began. Attendances referred by general practitioners (GPs)
dropped by 13 percentage points in the Delay phase and remained at that level. While changes in living conditions explain much of the decrease in overall attendance and in GP referrals, reduced attendance for complex chronic conditions may indicate avoidance
behaviour and continued surveillance is necessary. |
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McGuinness, MJ, Hsee, et al |
ANZ J Surg |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to evaluate the impact of the national lockdown on emergency general surgery. A retrospective
analysis was performed of all patients admitted to Auckland City Hospital via the Acute Surgical Unit during lockdown from 26 March to 27 April 2020. The number of admissions decreased by 26% (p-value 0.000). A 56.8% decrease in patients presenting with trauma
was found (p-value 0.002). After exclusion of trauma patients, no statistical difference in discharge diagnosis was found. There was a 43.6% reduction in operations performed (p-value 0.037). There was a difference found in the management of appendicitis and
cholecystitis (p-value 0.003). Median length of stay was decreased from 1.8 to 1.3 days (p-value 0.031). |
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Meher, BK, Hawaldar, et al |
International Journal of Energy Economics and Policy |
Economics | Économie |
In this study, an attempt has been made to estimate the price volatility of crude oil and natural gas listed on multi
commodity exchange of India (MCX). We measured the leverage effect of COVID-19 on price volatility of crude oil and natural gas by using the daily prices of crude oil and natural gas from May 01, 2017 to April 30, 2020. The findings of the study reveal that
there is a presence of leverage effect of COVID-19 on the price volatility of crude oil. However, this leverage effect is not present on the price volatility of natural gas. The findings of the study will help investors to develop investment strategies and
to the policymakers to formulate appropriate policies to overcome or minimise the impact of COVID-19. |
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Mei-Hong, W, Bin, et al |
Academic Journal of Second Military Medical University |
Therapeutics| Thérapeutique |
Objective To evaluate the clinical efficacy and safety of hydroxychloroquine sulfate combined with azithromycin in
the treatment of refractory common coronavirus disease 2019 (COVID-19) patients. Methods The clinical data of 11 refractory common COVID-19 patients, who were admitted to Guanggu Branch of Maternity and Child Healthcare Hospital of Hubei Province from Mar.
22 to 25, 2020, were retrospectively collected. The patients all received combined treatment regimens: hydroxychloroquine sulfate orally 200 mg three times daily for 7 days; and azithromycin orally 500 mg once daily on day 1 and then 250 mg once daily from
day 2 to day 4. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid test of throat swab was performed once daily from day 4 to day 10 after combined administration, and the blood routine and other laboratory indicators were tested
within 3 days before administration and on the 8th days after administration. Results All the 11 patients had common COVID-19, seven of them were consistently positive for SARSCoV- 2 nucleic acid test, and four were positive again after negative results. The
average course of disease of 11 patients before combined administration was 50.2 days. The treatment process was uneventful. Zero case of SARS-CoV-2 nucleic acid test result turned negative on day 4 after administration, two cases on day 5, two cases on day
6, two cases on day 7, one case on day 8 and one case on day 9. No patients progressed to severe or critical illness, and no severe side effects were found. Conclusion Hydroxychloroquine sulfate combined with azithromycin is safe and effective in the treatment
of refractory common COVID-19 patients who have ailed in other treatments and are consistently positive for SARS-CoV-2 nucleic acid. © 2020 Second Military Medical University Press. All rights reserved. |
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An early prediction of covid-19 associated hospitalization surge using deep learning approach |
Meng, Yuqi, Zhao, et al |
arXiv |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The global pandemic caused by COVID-19 affects our lives in all aspects. As of September 11, more than 28 million people
have tested positive for COVID-19 infection, and more than 911,000 people have lost their lives in this virus battle. Some patients can not receive appropriate medical treatment due the limits of hospitalization volume and shortage of ICU beds. An estimated
future hospitalization is critical so that medical resources can be allocated as needed. In this study, we propose to use 4 recurrent neural networks to infer hospitalization change for the following week compared with the current week. Results show that sequence
to sequence model with attention achieves a high accuracy of 0.938 and AUC of 0.850 in the hospitalization prediction. Our work has the potential to predict the hospitalization need and send a warning to medical providers and other stakeholders when a re-surge
initializes. |
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Mesnier, Jules, Cottin, et al |
The Lancet Public Health |
Healthcare Response | Réponse des soins de santé |
BackgroundThe COVID-19 pandemic has had a profound effect on general health care. We aimed to evaluate the effect of
a nationwide lockdown in France on admissions to hospital for acute myocardial infarction, by patient characteristics and regional prevalence of the pandemic. |
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Meyers, C, Robison, et al |
J Med Virol |
Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) Healthcare Response | Réponse des soins de santé |
OBJECTIVES: The emergence of the SARS-CoV-2 pandemic has created an unprecedented healthcare, social, and economic
disaster. Wearing of masks and social distancing can significantly decrease transmission and spread, however due to circumstances such as medical or dental intervention and personal choice these practices have not been universally adopted. Additional strategies
are required to lessen transmission. Nasal rinses and mouthwashes, which directly impact the major sites of reception and transmission of HCoV, may provide an additional level of protection against the virus. METHODS: Common over-the-counter nasal rinses and
mouthwashes/gargles were tested for their ability to inactivate high concentrations of HCoV using contact times of 30 sec, 1 min, and 2 min. Reductions in titers were measured by using the tissue culture infectious dose 50 (TCID50) assay. RESULTS: A 1% baby
shampoo nasal rinse solution inactivated HCoV greater than 99.9% with a 2 min contact time. Several over-the-counter mouthwash/gargle products including Listerine and Listerine-like products were highly effective at inactivating infectious virus with greater
than 99.9% even with a 30 sec contact time. CONCLUSION: In the current manuscript we have demonstrated that several commonly available healthcare products have significant virucidal properties with respect to HCoV. This article is protected by copyright. All
rights reserved. |
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Miarons, M, Larrosa-García, et al |
Transplantation |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We conducted a matched retrospective cohort study to compare clinical outcomes among solid organ transplant (SOT) recipients
with the general population and to assess immunosuppression management. Forty-six transplant recipients and 166 control patients were included. Mean (SD) age of transplant recipients and controls was 62.7 (12.6) and 66.0 (12.7) years, 33 (71.7%) and 122 (73.5%)
were male, and median (IQR) Charlson's Index was 5 (3-7) and 4 (2-7), respectively. Mortality was 37.0% in SOT recipients and 22.9% in controls (p=0.51).Thirty-three (71.7%) patients underwent transitory discontinuation of immunosuppressants due to potential
or confirmed DDI. In conclusion, hospitalized SOT recipients with COVID-19 had a trend toward higher mortality compared to controls, although it was not statistically significant, and a notable propensity for DDI. |
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Mitra, Debanjan, Pal, et al |
Research Square prepub |
Coronavirology| Coronavirologie |
In this study, all protein sequences of SARS-CoV-2 and SARS are retrieved from the database to check their physicochemical,
evolutionary and structural properties. Results showed that, charged residues are playing a key role in SARS-CoV-2 evolution. SARS-CoV-2 increases its polarity by the help of charged residues, not by the polar residues. Their divergence is also strictly restricted.
Induction of salt bridges with their high energies makes it very stable in any extreme conditions. Microenvironment residues also play a very crucial role in its stability. Mostly residues are favorable and contribute high energies. These microenvironment
residues help in protein engineering to reduce its stability and make them week. |
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Perspectives of medical students on medical education services during the COVID-19
pandemic in India |
Mitra, M, Basu, et al |
International Journal of Current Research and Review |
Healthcare Response | Réponse des soins de santé |
This study aimed to understand the perspectives of the medical students on the different teaching methods adopted and
the acceptability of those mechanisms. It was undertaken between 1 May 2020 to 15 May 2020 in 600-bed tertiary care teaching hospital in India having affiliation for both undergraduate and postgraduate medical teaching. A pre-structured questionnaire was randomly
distributed to 500 students. Results: So far as the different methods of online teaching are concerned, the Interactive online sessions were attended by 59.5% of the study respondents, 28.3% of the study respondents mentioned attending webinars while uploaded
lectures were attended by 12.2% study respondents. 150 (57.3%) of the respondents mentioned that the online training sessions were equally effective as in-person training classes. However, a sizeable proportion of 90 (34.3%) respondents mentioned that the
online training sessions were less effective. |
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Mohammadi, MR, Zarafshan, et al |
Iranian Journal of Psychiatry |
Public Health response| Interventions de santé publique |
We investigated the level of psychological problems, perceived risk, safety behaviors, and the potential roles of demographic
variables, public trust, media, and prior anxiety to illness during the COVID-19pandemic among Iranians. Our final sample consisted of 1881 Iranian residents. The mental health problems have increased in comparison to past national survey; 24.1% vs 10.39%
for depression, 37.93% vs 16.7% for social dysfunction, and 41.33% vs 29.5% for anxiety, and 31.12% vs 29.08% for somatization. We also found high percent of acute stress 52.71% (95% CI: 50.45-54.96). Being female, married, and having a higher educational
level increased the odds of safety behaviors. Public trust and national media can regulate the negative effect of the pandemic, while increasing perceived risk and appropriate safety behaviors can decrease psychological problems and disorders. |
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Mohammadpour, M, Ghorbani, et al |
Iranian Journal of Psychiatry |
Public Health response| Interventions de santé publique |
This study aimed to investigate the relationship between anxiety, self-compassion, and gender differences with self-care
behaviors and fear of COVID-19 in Kermanshah. Method: In the cross-sectional study, 403 people answered online questions on the Generalized Anxiety Disorder 7-Item (GAD-7) Scale, Self-Compassion Scale (SCS), Fear of COVID-19 Scale (FCV-19S), and a questionnaire
focusing on COVID-19-related behavior. Pearson correlation coefficient and regression analysis were used for data analysis. According to the findings, men and people who are less afraid of COVID-19 are more likely not to observe self-care behaviors. |
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Mousavi, SAM, Hooshyari, et al |
Iranian Journal of Psychiatry |
Public Health response| Interventions de santé publique |
This study has identified stressful events experienced by Iranian adults during the COVID-19 epidemic. Method: Data
on stressful events during the COVID-19 epidemic were collected online from 418 adults using quota sampling method. Results: The most frequent stressful event was rise in essential goods prices (84.7%); however, its perceived stress was not at the highest
level. The highest severity of perceived stress was related to the death of a family member (4.83) due to COVID-19 infection, which was an event with the least occurrence, and the lowest severity of perceived stress was related to medical team performance
(2.50). The results showed the severity of perceived stress is higher in women than men (t = 3.42; P value < 0.01) and also in the laboring occupations compared to other occupations (F = 3.18; P value < 0.05). |
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Why people comply with COVID-19 social distancing restrictions: Self-interest or
duty? |
Murphy, K, Williamson, et al |
Australian and New Zealand Journal of Criminology |
Public Health response| Interventions de santé publique |
This article uses survey data from 1595 Australians to examine compliance with COVID-19 lockdown restrictions in the
early stages of the pandemic. Results revealed that a substantial number of Australians did not comply fully with the measures. Further, while self-interest and health concerns motivated compliance, normative concerns regarding duty to support the authorities
dominated compliance decisions. The findings’ implications for both compliance research and for authorities wanting to nurture voluntary compliance with public health orders are discussed. |
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Nachtigall, I, Lenga, et al |
Clinical Microbiology and Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objectives: In Germany the coronavirus disease 2019 (COVID-19) pandemic situation is unique among large European countries
in that incidence and case fatality rate are distinctly lower. We describe the clinical course and examine factors associated with outcomes among patients hospitalized with COVID-19 in Germany. Methods: In this retrospective cohort study we included patients
with COVID-19 admitted to a national network of German hospitals between February 12 and June 12, 2020. We examined demographic characteristics, comorbidities and clinical outcomes. Results: We included 1904 patients with a median age of 73 years, 48.5% (924/1904)
of whom were female. The mortality rate was 17% (317/1835; 95% confidence interval (95%CI) 16–19), the rate of admission to the intensive care unit (ICU) was 21% (399/1860; 95%CI 20–23), and the rate of invasive mechanical ventilation was 14% (250/1850: 95%CI
12–15). The most prominent risk factors for death were male sex (hazard ratio (HR) 1.45; 95%CI 1.15–1.83), pre-existing lung disease (HR 1.61; 95%CI 1.20–2.16), and increased patient age (HR 4.11 (95%CI 2.57–6.58) for age >79 years versus <60 years). Among
patients admitted to the ICU, the mortality rate was 29% (109/374; 95%CI 25–34) and higher in ventilated (33% 77/235; 95%CI 27–39]) than in non-ventilated ICU patients (23%, 32/139; 95%CI 16–30; p < 0.05). Conclusions: In this nationwide series of patients
hospitalized with COVID-19 in Germany, in-hospital and ICU mortality rates were substantial. The most prominent risk factors for death were male sex, pre-existing lung disease, and greater patient age. © 2020 The Author(s) |
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Social network analysis methods for exploring SARS-CoV-2 contact tracing data |
Nagarajan, K, Muniyandi, et al |
BMC Med Res Methodol |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission
Public health interventions*| Interventions de santé publique |
METHODS: Standard social network analysis methods used for exploring infectious disease transmission dynamics was employed
to analyze contact tracing data of 1959 diagnosed SARS-CoV-2 patients from a large state of India. RESULTS: Out-degree centrality measures identified that of the total 1959 patients, 11.27% (221) patients have acted as a source of infection to 40.19% (787)
other patients. Among these source patients, 0.65% (12) patients had a higher out-degree centrality (> = 10) and have collectively infected 37.61% (296 of 787), secondary patients. Betweenness centrality measures highlighted that 7.50% (93) patients had a
non-zero betweenness (range 0.5 to 135) and thus have bridged the transmission between other patients. Network component analysis identified nineteen connected components comprising of influential patient's which have overall accounted for 26.95% of total
patients (1959) and 68.74% of epidemiological contacts in the network. |
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Depression and anxiety among iranian medical students during COVID-19
pandemic |
Nakhostin-Ansari, A, Sherafati, et al |
Iranian Journal of Psychiatry |
Healthcare Response | Réponse des soins de santé |
This study aimed to determine depression and anxiety levels among Iranian medical students during the COVID-19 pandemic.
Method: In this cross sectional study, we designed an online survey of Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) questionnaires. The survey link was sent to 500 medical clerks and interns studying at Tehran University of Medical Sciences
. A total of 64.6% of the students completed the survey. The prevalence of mild to severe anxiety and depression among them was 38.1% and 27.6%, respectively. Anxiety and changes in sleep patterns were the most common symptoms. Higher levels of anxiety were
related to female gender, lower grade point average (GPA), and experience of COVID-19 symptoms. Students with lower GPA and prior experience of COVID-19 symptoms were more likely to feel depressed. |
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A multivariate analysis on spatiotemporal evolution of Covid-19 in Brazil |
Nascimento, MLF |
Infectious Disease Modelling |
Epidemiology| Épidémiologie |
This work aims to analyze and classify the spatiotemporal distribution of all Brazilian states considering data such
as the number of Covid-19 cases, deaths, confirmed cases per 100 k inhabitants, mortality per 100 k inhabitants and case fatality rates as health indicators. We considered population, area and population density as geographic indicators. GDP and HDI were
taken into account as economic and social criteria. Data were collected from April 3rd until August 8th, 2020. |
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SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood |
Ng, DL, Goldgof, et al |
Nat Commun |
Epidemiology| Épidémiologie Immunology | Immunologie |
Given the limited availability of serological testing to date, the seroprevalence of SARS-CoV-2-specific antibodies
in different populations has remained unclear. Here, we report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seroreactivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood
donors in early April 2020. We additionally describe the longitudinal dynamics of immunoglobulin-G (IgG), immunoglobulin-M (IgM), and in vitro neutralizing antibody titers in COVID-19 patients. The median time to seroconversion ranged from 10.3-11.0 days for
these 3 assays. Neutralizing antibodies rose in tandem with immunoglobulin titers following symptom onset, and positive percent agreement between detection of IgG and neutralizing titers was >93%. These findings emphasize the importance of using highly accurate
tests for surveillance studies in low-prevalence populations, and provide evidence that seroreactivity using SARS-CoV-2 anti-nucleocapsid protein IgG and anti-spike IgM assays are generally predictive of in vitro neutralizing capacity. |
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Analysis of Factors Affecting Virus Survival on Object Surface and in
Air |
Niu, L, Liang, et al |
Research of Environmental Sciences |
Coronavirology| Coronavirologie |
Article in Chinese. There are few reports on factors influencing the transmission of 2019-nCoV, such as environmental
conditions (humidity and temperature), air pollution, and human activities. It is difficult to sample and research 2019-nCoV directly. Therefore, it is significant to investigate the factors influencing the spread and survival of other similar viruses, which
is instructional for the prevention of epidemics and the control of 2019-nCoV transmission. Amongst the results : (1) Low temperature and low humidity could prolong the lifetime and increase the transmission of coronavirus, especially on dry surfaces. For
example, coronavirus can survive on a smooth surface at a temperature of 22-25
℃ and a relative humidity (RH) of 40%-45% for more than 5 days.
(2) Similarly, the survival rates of the aerosolized coronavirus is also high in a closed environment at low temperature and low humidity, 2019-nCoV may hold high survival rates at a temperature of 20-25
℃ and a relative humidity of 30%-50%. |
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Normalina, I, Indrasari, et al |
Systematic Reviews in Pharmacy |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We characterized the spike (S) glycoprotein gene from the Indonesian SARS-CoV-2 isolates to investigate its genetic
composition, predict the B cell epitopes, and construct the molecular phylogenetic among Indonesian SARS-CoV-2 isolates. Methods: We employed Wuhan-Hu-1 isolate available in GenBank, NCBI and fourteen Indonesian SARS-CoV-2 isolates acquired from the database
(GISAID EpiCoV). We performed using the MEGA X for genetic and amino acid mutations and construct molecular phylogenetic tree. We used IEDB web server to predict epitopes, evaluated allergenicity by applying AllerTOP v.2.0 web server, and non-toxic antigens
applying the ToxinPred web server. Results: Interestingly, we discovered that the Indonesian SARS-CoV-2 isolates genetic composition do not have significant changes compared with the reference sequence based on the S glycoprotein gene. In addition, we proposed
NSASFSTFKCYGVSPTKLNDLCFTNV as a candidate for a peptide-based vaccine against COVID-19. |
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Norooznezhad, AH, Eskandarion, et al |
J Med Virol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Our objective was to evaluate changes in CBC Diff variables of uncomplicated pregnant women with confirmed COVID-19
infection in two states before and after Ceasarean delivery. This retrospective case-control multicentre study was performed between March 3 and May 10, 2020, in five hospitals. A sub-group analysis for symptomatic COVID-19 confirmed cases (75%, 15/20)
was also performed. The most common symptoms in the symptomatic group were dyspnea (80%), fever (60%), and myalgia (46.5%) respectively. Statistically significant findings between the cases and controls, as well as between the symptomatic and symptomatic
cases are reported. |
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Nigeria media framing of coronavirus pandemic and audience response |
Nwakpu, ES, Ezema, et al |
Health Promotion Perspectives |
Public Health response| Interventions de santé publique |
This study evaluates how Nigerian media depict the coronavirus pandemic and how the depictions shape people’s perception
and response to the pandemic. Methods: The study employed a quantitative design (newspaper content analysis and questionnaire). The content analysis examines the nature of media coverage of coronavirus in Nigeria and China using four major national newspapers.
The period of study ranged from January 2020 to March 2020. A total of 1070 newspaper items on coronavirus outbreak were identified. The finding shows that the coverage of the pandemic was dominated by straight news reports accounting for 71.3% of all analysed
items. This was followed by opinions 15.8%, features 11.2% and editorials 1.7% . Finding further suggests that the framing pattern adopted by the newspapers helped Nigerians to take precautionary measures. However, the newspapers should avoid creating fear/panic
in reporting the pandemic. |
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Oben, J, Bigoga, et al |
Functional Foods in Health and Disease |
Public Health response| Interventions de santé publique |
The present study tested the acceptability of an improved version of the ‘Yellow soup’ which contains ingredients/spices
with known antibacterial/antiviral properties. Star Yellow was made by using a palm oil/limestone base to which was added spices /ingredients rich in zinc and known for their antiviral/antibacterial activity. Sensory evaluation of the resulting mixture was
done by a taste panel comprising habitual eaters of ‘Yellow soup’ using a hedonic scale of 1 to 5. Results and Conclusion: Sensory assessment of Star Yellow showed a mean acceptability of 77.4% compared to 54.8% obtained for the commercial Yellow Soup served
in restaurants. This indicates the acceptable taste of Star Yellow and opens up potential new avenues of research in the control of SARS-CoV-2 virus transmission via feces. |
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Communicating health crisis: A content analysis of global media framing of COVID-19 |
Ogbodo, JN, Onwe, et al |
Health Promotion Perspectives |
Public Health response| Interventions de santé publique |
This study examines the global media framing of COVID-19) to understand the dominant frames and how choice of words
compares in the media. The study utilises content analysis. Data were sourced from LexisNexis database and two websites that yielded 6145 items used for the analysis. Nine predetermined frames were used for the coding. Human Interest and fear/scaremongering
frames dominated the global media coverage of the pandemic. Global media coverage of COVID-19 was high, but the framing lacks coherence and sufficient self-efficacy and this can be associated with media’s obsession for breaking news. The preponderance of these
frames not only shapes public perception and attitudes towards the pandemic but also risks causing more problems for those with existing health conditions due to fear or panic attack. |
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Olsen, SJ, Azziz-Baumgartner, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Following widespread adoption of community mitigation measures to reduce transmission of SARS-CoV-2, the virus that
causes COVID-19, the percentage of U.S. respiratory specimens submitted for influenza testing that tested positive decreased from >20% to 2.3% and has remained at historically low interseasonal levels (0.2% versus 1–2%). Data from Southern Hemisphere countries
also indicate little influenza activity. |
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Olvera, A, Noguera-Julian, et al |
Vaccines |
Coronavirology| Coronavirologie Immunology | Immunologie |
To accelerate immune studies in SARS-CoV-2 infection, we here describe a SARS-CoV-2 2020 consensus sequence (CoV-2-cons)
which is based on more than 1700 viral genome entries in NCBI and encompasses all described SARS-CoV-2 open reading frames (ORF), including recently described frame-shifted and length variant ORF. Based on these sequences, we created curated overlapping peptide
(OLP) lists containing between 1500 to 3000 peptides of 15 and 18 amino acids in length, overlapping by 10 or 11 residues, as ideal tools for the assessment of SARS-CoV-2-specific T cell immunity. The identification of conserved protein fragments across the
coronavirus family and the corresponding OLP facilitate the identification of T cells potentially cross-reactive with related viruses. This new CoV-2-cons sequence, together with the peptides sets, should provide the basis for SARS-CoV-2 antigen synthesis
to facilitate comparability between ex-vivo immune analyses and help to accelerate research on SARS-CoV-2 immunity and vaccine development. |
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Ong, DSY, Claas, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The aim of this study was to assess the diagnostic performance of the GeneFinderTMCOVID-19 Plus RealAmp Kit on the
ELITe InGenius sample-to-result platform, which is a commercial nucleic acid amplification test (NAT) targeting genes of SARS-CoV-2. Patients were eligible between March 18 and May 27, 2020, when they had respiratory symptoms that were suspected for COVID-19.
The InGenius platform was compared to routine in-house NAT that was validated according to the national reference. Results indicated that the InGenius platform for SARS-CoV-2 detection has excellent sensitivity, is easy to use and provides fast results. The
inclusion of the N gene as a third gene target may further increase sensitivity for the diagnosis of COVID-19 in comparison to the national reference method. |
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Opinc, A, Łukasik, et al |
Reumatologia |
Healthcare Response | Réponse des soins de santé |
The goal of the study was to recognize the needs and expectations as well as the main concerns of Polish rheumatology
patients in regard to teleconsultations. An online-based questionnaire was collected among Polish rheumatology patients directly after the introduction of specialist teleconsultations. |
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32822884; Proactive screening approach for SARS-CoV-2 among healthcare workers |
Oster, Y, Wolf, et al |
Clinical Microbiology and Infection |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
This article presents the results of the first 2 months of a health care worker screening programme in a Jerusalem
hospital. The novel proactive periodic screening programme for SARS-CoV-2 for all personnel was put in place in order to create a safe hospital environment for staff members and patients. |
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Case Report: A Patient with COVID-19 under Myelosuppression Induced by Chemotherapy |
Otsuka, Y, Kobayashi, et al |
Am J Trop Med Hyg |
Clinical data| Données cliniques |
COVID-19 has now spread globally, and 10-20% of the cases are thought to proceed to a severe condition. However, information
on COVID-19 in immunodeficient patients remains limited. We treated a 56-year-old man who developed COVID-19 after chemotherapy for mantle cell lymphoma. After 1 month of prolonged fever, the patient's respiratory condition deteriorated rapidly, and he died.
COVID-19 in immunocompromised patients after chemotherapy, even with mild symptoms, can cause rapid immune reconstitution and respiratory deterioration. Therefore, caution is advised until negative PCR test results for SARS-CoV-2 are confirmed. |
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In silico, 6lu7 protein inhibition using dihydroxy-3-phenyl coumarin derivatives for
SARS-CoV-2 |
Özdemir, M, Köksoy, et al |
Journal of the Turkish Chemical Society, Section A: Chemistry |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
Authors tested 42 coumarin derivatives containing 14 different substituents, which are secondary metabolites of plants,
and the anticoagulant Coumadin (warfarin) drug as a reference by Molecular Docking calculation technique on 6LU7 main protease of the coronavirus. The coumarins data reported in this study serves as a stepping stone for in vitro and in vivo experimental research
for vaccine development purposes. |
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Pacheco-Barrios, K, Cardenas-Rojas, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study tested Farr’s Law assumptions by modeling COVID-19 data of new cases and deaths.
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Palamar, JJ, Acosta, et al |
International Journal of Drug Policy |
Public Health response| Interventions de santé publique |
Authors discuss the popularity of virtual raves and happy hours which have increased during the COVID-19 pandemic,
and whether virtual events are associated with drug use. |
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Palermo, AE, Cahalin, et al |
Spinal Cord Ser Cases |
Clinical data| Données cliniques |
In this study, the authors discuss how individuals with spinal cord injury (SCI) are at high risk of developing COVID-19
related respiratory complications (RC). |
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Analysis of covid-19 cases in the philippines using sigmoidal-type models |
Palugapaluga, RN, Paluga, et al |
Journal of Advanced Research in Dynamical and Control Systems |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, a new method of curve-fitting analysis is introduced, and applied to several sigmoidal-type models in
order to come up with an estimate of the accumulated number of COVID-19 positive cases in the Philippines. The best fit model is obtained using a new criterion and will then be utilized for forward predictions of COVID-19 cases in the Philippines. © 2020,
Institute of Advanced Scientific Research, Inc.. All rights reserved. |
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United We Stand: Transfer Graph Neural Networks for Pandemic Forecasting |
Panagopoulos, George, Nikolentzos, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, authors study the impact of population movement on the spread of COVID-19, and we capitalize on recent
advances in the field of representation learning on graphs to capture the underlying dynamics. |
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Pande, D, Kochhar, et al |
Indian Journal of Palliative Care |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This case series describes the initial experience of an ICU in India regarding epidemiological profile, clinical course,
and outcome of critically ill COVID-19 patients. |
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Parr, Thomas, Bhat, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Immunology | Immunologie |
This paper introduces a model of the immune response to a virus such as COVID-19. |
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Parra-Bracamonte, G, Lopez-Villalobos, et al |
Annals of Epidemiology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The purpose of this study was to assess clinical characteristics and risk factors for mortality of patients with coronavirus
disease 2019 (COVID-19) from Mexico, given that it currently is in active community transmission. A more vulnerable positive patient is depicted by a male patient, older than 41 years, which increases their risk with more prevalent comorbidities such as diabetes,
hypertension, and obesity. |
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Change in Antibodies to SARS-CoV-2 Over 60 Days Among Health Care Personnel in Nashville,
Tennessee |
Patel, MM, Thornburg, et al |
Jama |
Clinical data| Données cliniques Immunology | Immunologie |
Authors evaluated anti–SARS-CoV-2 antibodies at baseline and approximately 60 days later in a convenience sample of
health care personnel at Vanderbilt University Medical Center who regularly had direct contact with adult patients with COVID-19. Anti–SARS-CoV-2 antibodies to the spike protein, which have correlated with neutralizing antibodies,5 decreased over 60 days in
health care personnel, with 58% of seropositive individuals becoming seronegative. |
|
Patra, S, Patro, et al |
Asian Journal of Psychiatry |
Public Health response| Interventions de santé publique |
We evaluated the impact of lockdown and school closure caused by COVID-19 situation on mental well-being, behaviour,
screen media use of children diagnosed with psychiatric disorders and seeking care from a specialized Child and Adolescent Psychiatry services of a tertiary care medical centre in eastern India. This was a cross sectional telephonic interview -based study
from 1st June 2020 to 8th July 2020. This is the first study from India reporting on child mental health during COVID-19 pandemic. Our study design had included potentially positive as well as negative effect of lockdown and school closure on children’s well-being. |
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Short-run environmental effects of COVID-19: Evidence from forest fires |
Paudel, J |
World Development |
Public Health response| Interventions de santé publique |
This article employs satellite data on real-time active fire locations in Nepal to evaluate the short-term environmental
effects of COVID-19. |
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Peiró, T, Lorente, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
With the aim of drawing lessons for nursing education, the present study analyzed, during the weeks of peak infection
in Spain, the stress experience and coping strategies of a sample of 403 nurses from the Spanish health system.
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Boris Johnson in hospital: a Chinese gaze at Western democracies in the COVID-19
pandemic |
Peng, AY, Zhang, et al |
Media International Australia |
Public Health response| Interventions de santé publique |
In this article, we examine Chinese assessments of Western democratic systems in the context of the COVID-19 pandemic.
This research is based on an up-to-date case study of how Chinese Internet users discussed the UK Prime Minister – Boris Johnson’s infection with COVID-19 in late March and early April 2020. The research collected original data from the Chinese community question-answering
(CQA) site – Zhihu. Using a mixed-method approach, consisting of content analysis (CA) and thematic analysis (TA), we show how Zhihu users evaluate the incident (1) as a way to express their sentiments towards Boris Johnson, (2) as a case to assess British
politics and (3) as a vehicle for rationalizing their views on Western democratic systems in relation to China’s domestic politics. The research findings shed new light on a Chinese gaze at Western democratic systems in the COVID-19 pandemic crisis. © The
Author(s) 2020. |
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Pereira, MFB, Litvinov, et al |
Clinics |
Clinical data| Données cliniques |
The objective of this study was to assess the outcomes of pediatric patients with laboratory-confirmed COVID-19 with
or without multisystem inflammatory syndrome in children (MIS-C). |
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Perng, CL, Jian, et al |
PeerJ |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
In this study, authors developed and validated a rapid total nucleic acid extraction method based on real‐time RT-PCR
for reliable, high‐throughput identification of SARS-CoV-2 using the BD MAX platform.
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Necrotising Vasculitis in Covid-19: watch out for bowel perforation |
Persiano, Tonia, Grulli, et al |
Research Square prepub |
Clinical data| Données cliniques |
Authors report a case of a Covid-19 patient who developed a right colon perforation due to a pseudomembranous colitis
without Clostridium Difficile toxins finding associated to a necrotising vasculitis. |
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Preferences for Tobacco Cessation Information and Support During Covid-19 |
Pettigrew, S, Jun, et al |
J Addict Med |
Public Health response| Interventions de santé publique |
This study was conducted to identify how best to provide smoking cessation advice and support during the Covid-19
pandemic. |
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Fixed single-cell RNA sequencing for understanding
virus infection and host response |
Phan, Hoang Van, van Gent, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Authors present FD-seq, a high-throughput method for droplet-based RNA sequencing of paraformaldehyde-fixed, stained
and sorted single-cells. |
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Difficult inclusion and physical activity for distance didactics |
Pietro, M, Madonna, et al |
Journal of Physical Education and Sport |
Public Health response| Interventions de santé publique |
This study was carried out on a sample of 20 special education needs (SEN) subjects aged between 14 and 16, to verify
the effects of the lockdown due to the Covid-19 pandemic. The results were tabulated in the last ten days of the month of May highlighted growing difficulties in school performance, a growing lack of free time and the pursuit of class group cohesion, as well
as an almost generalized increase in body weight. |
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Malnutrition and nutritional therapy in patients with SARS-CoV-2 disease |
Pironi, L, Sasdelli, et al |
Clinical Nutrition |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Authors investigated the prevalence of malnutrition and the provided nutritional therapy for COVID-19 patients. Patient
energy and protein intake were at the lowest limit or below the recommended amounts, indicating the need for actions to improve the nutritional care practice. |
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32868032; Free-floating right heart thrombus with pulmonary embolism
in SARS-CoV-2 patient |
Pla, JJ, Rodriguez, et al |
Medicina clinica |
Clinical data| Données cliniques |
We present the case of a 74-year-old woman who presented to the emergency department with acute onset dyspnea on minimal
exertion which had developed over a period of 1 day. Although there is no clear consensus for the management of right heart thrombus associated with pulmonary embolism, thrombolysis is readily available and can be effective in carefully selected patients. |
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Longitudinal evaluation of the psychological impact of the COVID-19 crisis in Spain |
Planchuelo-Gómez, Á, Odriozola-González, et al |
Journal of affective disorders |
Public Health response| Interventions de santé publique |
The aim of this study was to assess the temporal evolution of the psychological impact of the COVID-19 crisis and lockdown
from two surveys, separated by one month, performed in Spain. |
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Porretta, AD, Baggiani, et al |
Pathogens |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We describe the epidemiology of New Delhi Metallo-Beta-Lactamase-Producing Carbapenem-Resistant Enterobacterales (NDM-CRE)
colonization/infection in a cohort of COVID-19 patients in an Italian teaching hospital. These patients had an increased risk of NDM-CRE acquisition versus the usual patients (75.9 vs. 25.3 cases/10,000 patient days). The co-infection significantly increased
the duration of hospital stay (32.9 vs. 15.8 days). © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
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Prabha, T, Dhanabal, et al |
International Journal of Research in Pharmaceutical Sciences |
Therapeutics| Thérapeutique |
Authors discuss a study that has been undertaken to search the novel co drugs for fight-ing against the COVID-19 disease
through an in-silico approach. |
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Prajapati, DP, Shahrvini, et al |
International Forum of Allergy and Rhinology |
Clinical data| Données cliniques |
A prospective, longitudinal study evaluating patient-reported and measured olfactory function using the validated 12-item
Brief Smell Identification Test (BSIT) was conducted on adult outpatients with COVID-19. |
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Prasojo, LD, Wijayanti, et al |
Studies in English Language and Education |
Public Health response| Interventions de santé publique |
The purpose of this study was to validate instruments regarding digital technology access among Indonesian English
as a Foreign Language (EFL) faculty members during COVID-19. The findings informed 25 valid and reliable indicators. The measured scale achieves psychometric properties. It can provide future studies with a tool to capture EFL faculties’ access to digital
technology. |
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Prates, ET, Garvin, et al |
Mol Biol Evol |
Coronavirology| Coronavirologie |
Authors apply proteome-wide comparative structural analysis aiming to identify the unique molecular elements in the
SARS-CoV-2 proteome that may explain the differing consequences. Results imply that the striking difference in the pervasiveness of SARS-CoV-2 and SARS-CoV among humans seems to significantly derive from molecular features that modulate the efficiency of viral
particles in entering the host cells and blocking the host immune response. |
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Prazuck, T, Colin, et al |
PLoS One |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Authors conducted a prospective observational study to evaluate the performance of two POC tests, COVID-PRESTO® and
COVID-DUO®, compared to the gold standard, RT-PCR (real-time reverse transcriptase polymerase chain reaction). |
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Preis, H, Mahaffey, et al |
Social Science and Medicine |
Public Health response| Interventions de santé publique |
Given the well-documented harms associated with elevated prenatal stress and the critical importance of developing
appropriately targeted interventions, authors investigated factors predictive of pandemic-related pregnancy stress. Practices that may alleviate pandemic-related stress such as minimizing disruptions to prenatal care, ensuring access to outdoor space, and
motivating engagement in health behaviors are of vital importance. |
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Punia, R, Kumar, et al |
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Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
The respiratory system is the part of the human body most affected by the virus, so the use of X-rays of the chest
may prove to be a more efficient way than the thermal screening of the human body. In this paper, we are trying to develop a method that uses radiology, i.e. X-rays for detecting the novel coronavirus. Along with the paper, we also release a dataset for the
research community and further development extracted from various medical research hospital facilities treating COVID-19 patients. |
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The COVID-19 pandemic impact on industries performance: An explorative study of Indonesian
Companies |
Purwanto, A, Fahlevi, et al |
Journal of Critical Reviews |
Economics | Économie |
The purpose of this study was to identify informations about the impacts of COVID-19 pademic to company performance.
This research use the case study qualitative approach. In this study, selected participants were 7 people of top management of some industries. For confidentiality purposes, partisipants are given the initials P1,P2,P3,P4,P5, P6 and P7. Semi- structured interviews
were conductedand a list of questions compiled for interviews was developed based on the related literature. The results of this study there are some impact of Covid-19 Pandemic such as reduce imports of raw materials, decrease sales, reducing production capacity,
order demand has declined and sales turnover has also decreased, difficulty in sending distribution of goods, working hours are divided into 2 shiftssome of our employees are on vacation and get 70% of salary, having trouble distributing goods, some employees
have received 80% of salaries only. This research could be adapted and adopted by other countries or in other regions. © 2020 Innovare Academics Sciences Pvt. Ltd. All rights reserved. |
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Exploring the covid-19 pandemic impact on the Indonesian students performance |
Purwanto, A, Fahlevi, et al |
Journal of Critical Reviews |
Public Health response| Interventions de santé publique |
The purpose of this research was to explore the Covid-19 Pandemic’s Impact on the Students of Indonesian Universities
Performance. |
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Qian, Z, Hai-Xia, et al |
Academic Journal of Second Military Medical University |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Objective To study the infection control of patients with coronavirus disease 2019 (COVID-19) during the hyperbaric
oxygen therapy, so as to provide references for hyperbaric oxygen therapy in public health events in the future. Methods A hyperbaric oxygen therapy and nursing team in wards and a full-time infection control nurse post were set up, the responsibilities of
infection control nurses were defined, nosocomial infection monitoring was carried out, and meticulous management in all aspects of infection control was carried out. The hand hygiene compliance rates (number of hand hygiene execution/total number of hand
hygiene indicators 100%) of doctors, nurses and patients were compared before and after supervision by full-time infection control nurses. After the implementation of the hyperbaric oxygen chamber disinfection, the severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) nucleic acid test was performed on multiple sites inside and outside the hyperbaric oxygen chamber and wards every week. Hyperbaric oxygen therapy was given to four COVID-19 patients in mobile single air compression chamber and the therapy effects
were observed. Results After supervision by fulltime infection control nurses, the hand hygiene compliance rates of the doctors, nurses and patients were all improved (82.94% 175/211] vs 73.27% 148/202], 94.70% 268/283] vs 89.39% 236/264], and 78.41% 69/88]
vs 46.64% 24/55]), and the differences were significant (χ2=5.663 5, 5.308 4, and 17.997 2, all P<0.05). After the implementation of the hyperbaric oxygen chamber disinfection, the SARS-CoV-2 nucleic acid test results were negative on the door handle, inside
and outside of the hyperbaric oxygen chamber, the surface of the transfer bed and the surface of ward supplies during the first and second weeks. The pulse oxygen saturation (SpO2) and the walking distance in six minutes of patients were both increased after
hyperbaric oxygen therapy compared with those before hyperbaric oxygen therapy ( 91.62±3.65]% vs 85.63±4.52]% and 346.3±43.6] m vs 272.2±61.9] m), and the differences were significant (t=2.062 1 and 1.957 4, P=0.042 and 0.049). The symptoms such as chest tightness
and shortness of breath were significantly improved after hyperbaric oxygen therapy. Computed tomography reexamination showed that the inflammatory lesions of lungs had subsided to different extents. Conclusion Hyperbaric oxygen nursing team and infection
control nurse post can promote and supervise the implementation of the infection control system and infection control measures, ensuring the infection monitoring of COVID-19 patients and the safety of patients and medical staff. © 2020 Second Military Medical
University Press. All rights reserved. |
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Radujkovic, A, Hippchen, et al |
Nutrients |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health
care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin D (VitD) status with disease severity and survival, we studied 185 patients
diagnosed with coronavirus disease 2019 (COVID-19) and treated at our center. VitD status at first presentation was assessed retrospectively using accredited laboratory methods. VitD deficiency was defined as serum total 25-hydroxyvitamin D level < 12 ng/mL
(<30 nM). Primary endpoint was severe course of disease (i.e., need for invasive mechanical ventilation and/or death, IMV/D). Within a median observation period of 66 days (range 2–92), 23 patients required IMV. A total of 28 patients had IMV/D, including
16 deaths. Ninety-three (50%) patients required hospitalization (inpatient subgroup). A total of 41 (22%) patients were VitD deficient. When adjusted for age, gender, and comorbidities, VitD deficiency was associated with higher risk of IMV/D and death (HR
6.12, 95% CI 2.79–13.42, p < 0.001 and HR 14.73, 95% CI 4.16–52.19, p < 0.001, respectively). Similar correlations were observed in the inpatient subgroup. Our study demonstrates an association between VitD deficiency and severity/mortality of COVID-19, highlighting
the need for interventional studies on VitD supplementation in SARS-CoV-2 infected individuals. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
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Mutational signatures in countries affected by SARS-CoV-2:
Implications in host-pathogen interactome |
Rahman, Syed Asad, Singh, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We are in the midst of the third severe coronavirus outbreak caused by SARS-CoV-2 with unprecedented health and socio-economic
consequences due to the COVID-19. Globally, the major thrust of scientific efforts has shifted to the design of potent vaccine and anti-viral candidates. Earlier genome analyses have shown global dominance of some mutations purportedly indicative of similar
infectivity and transmissibility of SARS-CoV-2 worldwide. Using high-quality large dataset of 25k whole-genome sequences, we show emergence of new cluster of mutations as result of geographic evolution of SARS-CoV-2 in local population ({greater than or equal
to}10%) of different nations. Using statistical analysis, we observe that these mutations have either significantly co-occurred in globally dominant strains or have shown mutual exclusivity in other cases. These mutations potentially modulate structural stability
of proteins, some of which forms part of SARS-CoV-2-human interactome. The high confidence druggable host proteins are also up-regulated during SARS-CoV-2 infection. Mutations occurring in potential hot-spot regions within likely T-cell and B-cell epitopes
or in proteins as part of host-viral interactome, could hamper vaccine or drug efficacy in local population. Overall, our study provides comprehensive view of emerging geo-clonal mutations which would aid researchers to understand and develop effective countermeasures
in the current crisis. |
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Ramachandra, S, Chavan, et al |
International Journal of Current Research and Review |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Objectives: Age Layered Population Structure (ALPS) which introduces time labels into a traditional Genetic Algorithm
(GA) is a novel search metaheuristic in overcoming premature convergence. There are two models of ALPS namely generational and steady-state with their own merits and demerits. Present work has been taken up to devise a search algorithm E-Hybrid-ALPS with the
combined concepts and advantages of both the models. Methodology: E-Hybrid-ALPS not only combined the concepts and advantages of both the models but also considered weak individual solutions to the mating pool and adaptively applied the crossover operator.
A search algorithm, a component of the molecular docking tool plays a vital role in the success of molecular docking used in drug discovery. Hence, E-Hybrid-ALPS has been implemented as a search algorithm for molecular docking. The execution was carried out
with two receptor-ligand combinations namely receptor CYP2C8 and ligand Chloroquine, a therapeutic option in the treatment of Corona Virus Disease (COVID-19) and also a drug used in the treatment of Malaria and receptor CYP2B6 and ligand Cyclophosphamide a
drug used in the treatment of cancer. Results: E-Hybrid-ALPS generates poses of the ligand in the active site of the receptor, calculates the binding energy of each pose and outputs the pose with the lowest binding energy. The performance was evaluated by
comparing it with the widely used molecular docking tools AutoDock and AutoDockVina which employ Lamarckian GA as a search algorithm. Lowest binding energy found by E-Hybrid-ALPS was significantly low as compared to the lowest binding energy found by AutoDock
and AutoDockVina Conclusion: E-Hybrid-ALPS which generates a ligand/drug pose with the lowest binding energy can be implemented as a search algorithm for AutoDock molecular docking tool. This helps the drug discoverer in designing a drug with a better binding
affinity as lower binding energies indicate higher binding affinity. © IJCRR. |
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Ramírez, P, Gordón, et al |
Medicina Intensiva |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective: Information from critically ill coronavirus disease 2019 (COVID-19) patients is limited and in many cases
coming from health systems approaches different from the national public systems existing in most countries in Europe. Besides, patient follow-up remains incomplete in many publications. Our aim is to characterize acute respiratory distress syndrome (ARDS)
patients admitted to a medical critical care unit (MCCU) in a referral hospital in Spain. Design: Retrospective case series of consecutive ARDS COVID-19 patients admitted and treated in our MCCU. Setting: 36-bed MCCU in referral tertiary hospital. Patients
and participants: SARS-CoV-2 infection confirmed by real-time reverse transcriptase–polymerase chain reaction (RT-PCR) assay of nasal/pharyngeal swabs. Interventions: None Main variables of interest: Demographic and clinical data were collected, including
data on clinical management, respiratory failure, and patient mortality. Results: Forty-four ARDS COVID-19 patients were included in the study. Median age was 61.50 (53.25 – 67) years and most of the patients were male (72.7%). Hypertension and dyslipidemia
were the most frequent co-morbidities (52.3 and 36.4% respectively). Steroids (1mg/Kg/day) and tocilizumab were administered in almost all patients (95.5%). 77.3% of the patients needed invasive mechanical ventilation for a median of 16 days 11-28]. Prone
position ventilation was performed in 33 patients (97%) for a median of 3 sessions 2-5] per patient. Nosocomial infection was diagnosed in 13 patients (29.5%). Tracheostomy was performed in ten patients (29.4%). At study closing all patients had been discharged
from the CCU and only two (4.5%) remained in hospital ward. MCCU length of stay was 18 days 10-27]. Mortality at study closing was 20.5% (n 9); 26.5% among ventilated patients. Conclusions: The seven-week period in which our MCCU was exclusively dedicated
to COVID-19 patients has been challenging. Despite the severity of the patients and the high need for invasive mechanical ventilation, mortality was 20.5%. © 2020 Elsevier España, S.L.U. y SEMICYUC |
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Ramiro de Assis, Rafael, Jain, et al |
bioRxiv |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes Immunology
| Immunologie |
A coronavirus antigen microarray (COVAM) was constructed containing 11 SARS-CoV-2, 5 SARS-1, 5 MERS, and 12 seasonal
coronavirus recombinant proteins. The array is designed to measure immunoglobulin isotype and subtype levels in serum or plasma samples against each of the individual antigens printed on the array. We probed the COVAM with COVID-19 convalescent plasma (CCP)
collected from 99 donors who recovered from a PCR+ confirmed SARS-CoV-2 infection. The results were analyzed using two computational approaches, a generalized linear model (glm) and Random Forest (RF) prediction model, to classify individual specimens as either
Reactive or Non-Reactive against the SARS-CoV-2 antigens. A training set of 88 pre-COVID-19 specimens (PreCoV) collected in August 2019 and 102 positive specimens from SARS-CoV-2 PCR+ confirmed COVID-19 cases was used for these analyses. Results compared with
an FDA emergency use authorized (EUA) SARS-CoV2 S1-based total Ig chemiluminescence immunoassay (Ortho Clinical Diagnostics VITROS Anti-SARS-CoV-2 Total, CoV2T) and with a SARS-CoV-2 S1-S2 spike-based pseudovirus micro neutralization assay (SARS-CoV-2 reporter
viral particle neutralization titration (RVPNT) showed high concordance between the 3 assays. Three CCP specimens that were negative by the VITROS CoV2T immunoassay were also negative by both COVAM and the RVPNT assay. Concordance between VITROS CoV2T and
COVAM was 96%, VITROS CoV2T and RVPNT 93%, and RVPNT and COVAM 95%. The discordances were all weakly reactive samples near the cutoff threshold of the VITROS CoV2T immunoassay. The multiplex COVAM allows CCP to be grouped according to antibody reactivity patterns
against 11 SARS-CoV-2 antigens. Unsupervised K-means analysis, via the gap statistics, as well as hierarchical clustering analysis revealed 3 main clusters with distinct reactivity intensities and patterns. These patterns were not recapitulated by adjusting
the VITROS CoV2T or RVPNT assay thresholds. Plasma classified according to these reactivity patterns may be better associated with CCP treatment efficacy than antibody levels alone. The use of a SARS-CoV-2 antigen array may be useful to qualify CCP for administration
as a treatment for acute COVID-19 and to interrogate vaccine immunogenicity and performance in preclinical and clinical studies to understand and recapitulate antibody responses associated with protection from infection and disease.Competing Interest StatementThe
authors have declared no competing interest. |
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Rani, S, Bhattacharya, et al |
Journal of Communicable Diseases |
Public Health response| Interventions de santé publique |
Introduction: In December 2019, a novel coronavirus called SARS-CoV-2 resulted in the outbreak of a respiratory illness
known as COVID-19. The novel Coronavirus, 2019-nCoV, has been identified as the cause of outbreak of the pandemic that originated in Wuhan, China, and in quick succession spread to several other countries around the world. Objective: The study was taken up
to assess the knowledge and practice of community regarding prevention of Corona Virus Infectious Disease, to seek relationship between knowledge and practice regarding prevention of Corona virus disease and to seek association of knowledge and practice with
selected demographic variables. Method: The quantitative approach was adopted for the study with a descriptive survey design. Research variables were knowledge and expressed practice of community regarding prevention of COVID-19. The sample comprised of 503
people, selected through purposive sampling technique. An online survey was conducted to collect the data by using a structured questionnaire to assess knowledge and expressed practice regarding prevention of COVID-19. The data was analysed using descriptive
and inferential statistics. Result: The majority of the subjects i.e. 62.4% were in the age group of young adults 18-35 years, 50.1% were male and 83.7% of them studied up to graduation or more. 98.8% of the subjects had adequate knowledge and 99.8% had appropriate
expressed practice regarding prevention of corona virus disease. This indicates that community has good knowledge and practice as expressed by them. There was significant association between the knowledge of community regarding prevention of corona virus disease
with selected demographic variables i.e. age, educational status and source of information. Further, findings showed that there was a positive correlation between the knowledge and practice of community regarding prevention of COVID 19. Conclusion: Study concludes
that community has adequate knowledge and appropriate level of practice regarding prevention of corona virus disease. ©2020: Advanced Research Publications. |
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Sampling model on surveillance of COVID-19 virus among human populations |
Rao, AMKM, Kanchana, et al |
Journal of Communicable Diseases |
Surveillance |
India stands at 90,927 confirmed cases of Covid-19 infection with WHO classification of clusters of cases. The governments
around the world including India are mostly testing only people showing symptoms of flu, which are underestimating the real numbers due to presence of asymptomatic humans under virus incubation period. Random surveillance testing should, therefore, start as
soon as possible to establish the mortality rate and virality of the Coronavirus. Such surveillance for Covid-19 provides valuable early warning information about the spread of the virus and also reduces the uncertainty surrounding the true extent of the pandemic
and its mortality rate. Considered one of the most reliable forms of data collection, surveillance testing is takes small number of demographically representative random people to use as an estimate for the whole population. Due to these reasons, attempt was
made to develop a model for Covid-19 virus surveillance using rapid antibody testing method for screening the human populations on disease prevalence, which can be followed by rRT-PCR testing. This screening method was test checked in virtual situation in
Qutbullapur Municipality of Medak district, Telangana state, wherein three different areas High risk, Moderate risk and Low risk, each having 3 km area were identified in the Municipality with 2118 houses and projections were made for virtual sampling in 4
replicated unit areas. The projection of cost analysis came as Rs. 11,900 for first round rapid sample collection from randomly selected houses in entire Municipality, which appeared as a feasible financial projection for a disease like Covid-19. Major town/cities
can consider to adopt this as surveillance method for covid-19 virus. ©Copyright (c) 2020. |
|
Rathore, P, Kumar, et al |
Indian Journal of Palliative Care |
Healthcare Response | Réponse des soins de santé |
Objective: Health-care professionals (HCPs) are the frontline warriors in the time of this uncertain and unpredictable
crisis of COVID. They face many challenges while caring for these patients, yet they are expected to cope with it and deliver their duties for the betterment of humankind. Our primary aim was to identify and assess the concerns of HCPs working in COVID area
in a tertiary institutional isolation center. Methodology: An online Google-based questionnaire survey was distributed through various social media platforms after approval of the institutional review board to a total of 100 HCPs who were treating and managing
COVID-positive patients. Results: Of 100 responses, 72% were concerned about the risk of infection to self and family, while 46% reported disruption of their daily activities at a personal level. At the institutional level, 17% were concerned about inadequate
personal protective equipment-related challenges. 20% had inadequate knowledge and training about COVID. 16% of participants were anxious all the time, 11% feared all the time, and 12% had stress all the time while treating COVID patients. Connectedness and
communication with family and friends, word of appreciation, music, and TV were few strategies to cope up with these challenges. Conclusion: There is a need to identify and address the concerns and challenges faced by HCPs and to develop a comprehensive strategy
and guideline to provide a holistic care and to ensure their security in the workplace. © 2020 Wolters Kluwer Medknow Publications. All rights reserved. |
|
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Public awareness and preparedness towards covid-19 pandemic in pakistan |
Rehman, A, Yaqoob, et al |
Rawal Medical Journal |
Public Health response| Interventions de santé publique |
Objective: To exami ne the level of public awareness towards the coronavirus pandemic and knowledge about its preparedness.
Methodology: In this cross-sectional study, a self-administrated online questionnaire was circulated t hr ough emai l s and s oc i al medi a. The questionnaire comprised of close ended questions regarding assessing awareness about the causes and symptoms of
COVID-19 and knowledge about preventative measures required to be taken at i ndi vi dual and st at e l evel . A t ot al of 350 participants responded to the survey in the given time period of six days from 13th to 19th March 2020. The participants belonged
to all provinces of Pakistan including Azad Jammu Kashmir and Islamabad. Results: Public was aware of the COVID-19 epidemiological breakout, its causes, symptoms, modes of t ransmi ssi on and preparedness mechanism. The correlation matrix also depicted that
public awareness about the danger of COVID-19 were significantly correlated with t he preparedness at the individual and state levels. Conclusion: The general public was well aware of the COVID-19 epidemiological breakout, its causes, symptoms, modes of transmission
and prepar edness mechanism. © 2020, Pakistan Medical Association. All rights reserved. |
|
Ren, Y, Qian, et al |
Journal of affective disorders |
Public Health response| Interventions de santé publique |
Background: The mental health status caused by major epidemics is serious and lasting. At present, there are few studies
about the lasting mental health effects of COVID-19 outbreak. The purpose of this study was to investigate the mental health of the Chinese public during the long-term COVID-19 outbreak. Methods: A total of 1172 online questionnaires were collected, covering
demographical information and 8 common psychological states: depression, anxiety, somatization, stress, psychological resilience, suicidal ideation and behavior, insomnia, and stress disorder. In addition, the geographical and temporal distributions of different
mental states were plotted. Results: Overall, 30.1% of smokers increased smoking, while 11.3% of drinkers increased alcohol consumption. The prevalence rates of depression, anxiety, mental health problems, high risk of suicidal and behavior, clinical insomnia,
clinical post-traumatic stress disorder symptoms, moderate-to-high levels of perceived stress were 18.8%, 13.3%, 7.6%, 2.8%, 7.2%, 7.0%, and 67.9%, respectively. Further, the geographical distribution showed that the mental status in some provinces/autonomous
regions/municipalities was relatively more serious. The temporal distribution showed that the psychological state of the participants was relatively poorer on February 20, 24 to 26 and March 25, especially on March 25. Limitations: This cross-sectional design
cannot make causal inferences. The snowball sampling was not representative enough. Conclusion: Our findings suggest that the prevalence rate of mental disorders in the Chinese public is relatively low in the second month of the COVID-19 pandemic. In addition,
people's mental state is affected by the geographical and temporal distributions. © 2020 Elsevier Ltd |
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Various radiological findings in Indonesian patients with COVID-19: a case
series |
Riawati, Theresia, Indrarto, et al |
Research Square prepub |
Clinical data| Données cliniques |
Case series of 7 patients with COVID-19. |
|
Robiony, M, Bocin, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
We provide examples of clinical activity for a maxillofacial surgery department based on teleconsultation. Our experience
is summarized and an organization model is drafted in which outpatient consultation offices are translated into virtual room environments. Clinical examples are provided, demonstrating how each subspecialty of oral and maxillofacial surgery can benefit from
virtual examinations. The concept of “telesemeiology” is introduced and a checklist is presented to guide clinicians to perform teleconsultations. |
|
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Non-convulsive status epilepticus in a patient with COVID-19 infection |
Rodrigo-Armenteros, P, Uterga-Valiente, et al |
Clinical Neurophysiology |
Clinical data| Données cliniques |
Case report of a 62 ear old male |
|
Romero-Blanco, C, Rodríguez-Almagro, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
The aim of this study was to evaluate students’ physical activity and sedentary behaviour at two points in time: before
and during the coronavirus lockdown. As a secondary aim, we also wanted to look at changes resulting from other factors (alcohol, tobacco, diet, stages of change, symptoms of anxiety/depression and sociodemographic characteristics). We conducted an observational,
cross-sectional, pre-post study with two cut-off points. During lockdown, both weekly physical activity and weekly sitting time increased. In the group analysis, differences were observed in relation to gender, year of study, BMI, alcohol consumption, tobacco
use, symptoms of anxiety/depression, Mediterranean diet, living situation and stage of change. |
|
|
The Association between Symptoms and COVID-19 Test Results among Healthcare Workers |
Sacks, CA, Dougan, et al |
Ann Surg |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
Full article not available |
|
Saeki, T, Ogawa, et al |
Am J Phys Med Rehabil |
Clinical data| Données cliniques |
Case report of a 65 year old male |
|
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Assessing self-medication for obstructive airway disease during COVID-19 using
Google Trends |
Sahanic, S, Boehm, et al |
Eur Respir J |
Public Health response| Interventions de santé publique |
Using Google's search engine data analysis tool Google Trends, we aimed to investigate as to whether patients suffering
from COPD and/or asthma may have consulted the internet for behavioral and self-medication advice. Webserved a marked reduction in daily hospitalisations for COPD and asthma during the COVID-19 outbreak between February-April 2020 at our Department of Internal
Medicine, when compared to the years 2017–2019. In line, we observed a drop in hospitalisations for non-COVID-19 pneumonia, whereas COVID-19 associated hospitalisation rates dramatically increased, peaking on March 27, 2020. In summary, both social distancing
and lockdown measures together with increased self-medication and digital care-seeking may have reduced hospital admission rates in patients affected by obstructive respiratory disease during the COVID-19 outbreak in early 2020. |
|
Salari, M, Milne, et al |
Journal of Air Transport Management |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
We proposed a mixed integer programming model to assign passengers to seats on an airplane in a manner that will respect
two types of social distancing. One type of social distancing refers to passengers being seated far enough away from each other. The other type of social distancing refers to the distance between seat assignments and the aisle. To conduct simulation experiments,
we define different scenarios distinguishing between the relative level of significance of each type of social distancing. The results suggest the seating assignments that best serve the intention of the scenarios. The results show that the proposed scenarios
can provide social distancing among seated passengers similar to the middle-seat blocking policy, while reducing the number of passengers seated close to the aisle of an airplane. |
|
|
Saleh, OA, Jammal, et al |
Clinical Ophthalmology |
Healthcare Response | Réponse des soins de santé |
Purpose: To describe the clinical experience with the delivery of intravitreal injection therapy to patients with various
indications at a tertiary university hospital during the COVID-19 lockdown in Jordan. Methods: This is a retrospective observational study of patients who received intravitreal injections between April 12th and May 9th, 2020, a period during the national COVID-19
lockdown (March 16th to June 6th, 2020). Results: Intravitreal injections were successfully administered to 132 patients with diabetic retinopathy, age-related macular degeneration and retinal vein occlusion. All logistic and transmission control measures
were followed by the medical staff and patients with no incidents. No new exposures or COVID-19 positive cases were traced to our location or time of therapy. |
|
|
Comparison of Rhesus and Cynomolgus macaques as an
authentic model for COVID-19 |
Salguero, FranciscoJ, White, et al |
bioRxiv |
Clinical data| Données cliniques Animal model | Modèle animal |
Here, we show that SARS-CoV-2 replicates in the upper and lower respiratory tract and causes pulmonary lesions in both
rhesus and cynomolgus macaques, resembling the mild clinical cases of COVID-19 in humans. Importantly, we have devised a new method for lung histopathology scoring that will provide a metric to enable clearer decision making for this key endpoint. In contrast
to prior publications, in which rhesus are accepted to be the optimal study species, we provide convincing evidence that both macaque species authentically represent mild to moderate forms of COVID-19 observed in the majority of the human population and both
species should be used to evaluate the safety and efficacy of novel and repurposed interventions against SARS-CoV-2. |
|
Samad, A, Jafar, et al |
Genomics |
Coronavirology| Coronavirologie |
The analysis of ACE2 expression in lung cancer was performed using The Cancer Genome Atlas (TCGA). Therefore, we investigated
the prognosis, clinical characteristics, and mutational analysis of lung cancer. We also analyzed the shared proteins between the COVID-19 and lung cancer, protein-protein interactions, gene-miRNAs, gene-transcription factors (TFs), and the signaling pathway.
Finally, we compared the mRNA expression of ACE2 and its co-expressed proteins using the TCGA. The functional assessment of targeted 12,671, 3107, and 29 positive genes were found in COVID-19 disease, LUAD, and LUSC, respectively. This study uncovers the
relationship between COVID-19 disease and lung cancer. We identified ACE2 and also its co-expressed proteins are the potential biomarker and therapy as the current COVID-19 disease and lung cancer. |
|
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Eating Habits and Physical Activity of the Spanish Population during the COVID-19 Pandemic
Period |
Sánchez-Sánchez, E, Ramírez-Vargas, et al |
Nutrients |
Public Health response| Interventions de santé publique |
The objective of our study is to learn the dietary patterns, consumption, and physical activity of the Spanish population
before and during the period of confinement by COVID-19. A cross-sectional descriptive study based on a questionnaire during May 2020, coinciding with the period of confinement and the step forward into Phase 1, is carried out. During confinement, the adherence
to the Mediterranean Diet increases. No socio-demographic variables show statistical significance regarding good adherence to the Mediterranean Diet (MD) before and during confinement. During confinement, consumption of homemade baking shows a higher increase.
During confinement, the number of subjects that practice exercise decreases, as well as the time spent exercising. |
|
Sandín, B, Valiente, et al |
Revista de Psicopatologia y Psicologia Clinica |
Public Health response| Interventions de santé publique |
The objective of this work was to examine the psychological impact of the pandemic and the Spanish national quarantine
that took place during March and April 2020. We investigated the prevalence of fear of coronavirus, emotional symptoms and sleep problems. We also examined possible positive effects. A sample of 1,161 participants (aged 19 to 84 years) completed online the
Coronavirus Psychological Impact Questionnaire, the Intolerance to Uncertainty Scale–12, and the Positive and Negative Affect Schedule. Results indicated that the most common fears pertain to the domains of contagion/disease/death, social isolation, and employment/income
issues. We found high levels of emotional impact reflected in fear of coronavirus, sleep problems, and emotional symptoms (preoccupation, distress, hopelessness, depression, anxiety, nervousness, and restlessness). |
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COVID-19-Related anxiety in nurses working on front lines in Turkey |
Saricam, M |
Nursing and Midwifery Studies |
Healthcare Response | Réponse des soins de santé |
Objectives: The aim of this study was to investigate the pandemic related anxiety in nurses working in a university
hospital in Turkey. Methods: A questionnaire-based study was conducted to include 123 nurses working in the wards and intensive care units (ICUs). Results: Fifty-seven (46.3%) nurses demonstrated an elevated level of anxiety. COVID-19-related anxiety was closely
associated with advancing age and years of experience, having a child and working in the wards rather than ICUs (P 0.05). |
|
Sarma, R, Vig, et al |
Indian Journal of Palliative Care |
Healthcare Response | Réponse des soins de santé |
Our aim was to find out the concerns of HCPs working in non-COVID areas. Subjects and Methods: After obtaining institutional
ethics approval, a descriptive cross-sectional study was planned. An online Google-based questionnaire was rolled out to all doctors through various social media platforms who were dealing with COVID-negative patients. Results: We received a total of 110 responses.
84.5% of participants were concerned about the risk of infection to self and family, 67.3% were concerned by the disruption of their daily activities. 56.4% of HCPs were disturbed by the lack of any concrete protocol for patient management. |
|
|
Sato, T, Ueha, et al |
Laryngoscope |
Coronavirology| Coronavirologie Animal model | Modèle animal |
METHODS: To elucidate the underlying histological mechanisms of the aerodigestive disorders caused by SARS-CoV-2, we
investigated the expression of ACE2 and TMPRSS2 proteins using immunohistochemistry, in the aerodigestive tracts of the tongue, hard palate with partial nasal tissue, larynx with hypopharynx, trachea, esophagus, and lung of rats. RESULTS: Co-expression of
ACE2 and TMPRSS2 proteins was observed in the taste buds of the tongue, nasal epithelium, trachea, bronchioles, and alveoli with varying degrees of expression. Remarkably, TMPRSS2 expression was more distinct in the peripheral alveoli than in the central alveoli.
These results coincide with the reported clinical symptoms of COVID-19, such as the loss of taste, loss of olfaction, and respiratory dysfunction. |
|
|
Scialpi, M, Russo, et al |
Turkish Journal of Urology |
Clinical data| Données cliniques |
Case report of a 57 year old male with non-Hodgkin lymphoma and diagnosed with COVID-19 |
|
|
Overshooting of sovereign emerging eurobond yields in the context of COVID-19 |
Sène, B, Mbengue, et al |
Finance Research Letters |
Modelling/ prediction| Modélisation/prédiction Economics | Économie |
This paper illustrates the phenomenon of overshooting yields on eurobonds issued by emerging and developing countries
in the context of COVID-19. Using panel data from 48 emerging and developing countries, the results show that daily reports of confirmed cases have led to increases in yields and announcements of international creditor assistance to developing and emerging
countries, which have calmed investor concerns. |
|
Seo, WS, Kim, et al |
Yeungnam Univ J Med |
Healthcare Response | Réponse des soins de santé |
The goal of this work was to identify shortcomings in the conventional screening system (CSS) implemented in the beginning
of the outbreak. To overcome these shortcomings, we then introduced a novel, independently developed system called the Yeungnam University type drive-through (YU-Thru), and distributed it nationwide in Korea. YU-Thru system has shortened the time taken to
test a single person to 2-4 minutes, by completely eliminating the time required to clean and ventilate the specimen collection room. On average, 50 to 60 tests were conducted per day when using the CSS, while now up to 350 tests per day are conducted with
the YU-Thru system. We believe that the YU-Thru system has made an important contribution to the rapid detection of COVID-19 in Daegu, South Korea. |
|
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Online teaching placement during the COVID-19 pandemic in Chile: challenges
and opportunities |
Sepulveda-Escobar, P, Morrison, et al |
European Journal of Teacher Education |
Public Health response| Interventions de santé publique |
Due to school closures, teaching placements have had to shift from the face-to-face lessons to an entirely virtual
model. Twenty-seven Chilean English as a Foreign Language (EFL) teacher candidates participated in this interpretative case study aiming at exploring the challenges and opportunities of this virtual teaching experience. The results indicate that factors such
as the lack of direct interaction with learners and the sudden change of setting were among those that most strongly affected the participants’ own learning process. Despite the challenges presented, student teachers suggested that this unique experience would
contribute positively, at least to a certain extent, to their teacher education and their future careers. |
|
Sezer, A, Cicin, et al |
Turkish Journal of Surgery |
Healthcare Response | Réponse des soins de santé |
Here in this paper, we report the results of a consensus procedure which aimed to provide an expert opinion-led guideline
for breast cancer management during the COVID-19 outbreak in Turkey. Material and Methods: We used the Delphi method with a 9-scale Likert scale on two rounds of voting from 51 experienced surgeons and medical oncologists who had the necessary skills and experience
in breast cancer management. Results: There was a general consensus for administering neoadjuvant systemic therapy in patients with node-negative, small-size triple negative, HER2-positive and luminal A-like tumors until conditions are improved for due surgical
treatment. |
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|
Shah, T, Purohit, et al |
International Journal of Pharmaceutical Research |
Public Health response| Interventions de santé publique |
Online survey was done for all undergraduate health professional students of Sumandeep Vidyapeeth, deemed to be a university.
A questionnaire was made according to MOH information and validated to evaluate their knowledge, attitude and lifestyle modifications. Google form link was given to all the students through various online portals as G-mail, Whats app and Instagram page of
university. Total 910 students participated in the survey. Most of the students were aware about the spread, precautions and preventive measures of COVID-19. Students reported various attitudinal changes significantly during COVID-19 as use of sanitizer,
avoiding gathering, washing hands etc. Mixed response was obtained for online lectures and self directed learning during lock down from all levels of students. More studies are recommended to generate evidence and awareness through research on COVID-19. |
|
|
Shankaranarayanan, D, Muthukumar, et al |
Clin J Am Soc Nephrol |
Healthcare Response | Réponse des soins de santé |
Herein, we describe our experience with the life of 502 CRRT circuits on different anticoagulation regimens in 80 patients
with RT-PCR–confirmed COVID-19 who received continuous venovenous hemodialysis (NxStage System One) between March 5 and May 8, 2020. Circuit clotting was our analysis end point. Circuit life was the time (hours) from initiation of CRRT to clotting or censoring.
Clotting occurred in 203 (40%) circuits. Among 350 circuits with anticoagulation, 124 (35%) clotted, and among 152 with no anticoagulation, 79 (52%) clotted. Among circuits with anticoagulation, 13 (62%) with citrate, 33 (52%) with prefilter heparin, 63 (31%)
with systemic heparin, ten (26%) with argatroban, and five (19%) with citrate plus heparin clotted. |
|
|
Shannon, A, Selisko, et al |
Nat Commun |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The viral RNA-dependent-RNA-polymerase (RdRp) is a promising target with polymerase inhibitors successfully used for
the treatment of several viral diseases. We demonstrate here that Favipiravir predominantly exerts an antiviral effect through lethal mutagenesis. The SARS-CoV RdRp complex is at least 10-fold more active than any other viral RdRp known. It possesses both
unusually high nucleotide incorporation rates and high-error rates allowing facile insertion of Favipiravir into viral RNA, provoking C-to-U and G-to-A transitions in the already low cytosine content SARS-CoV-2 genome. The coronavirus RdRp complex represents
an Achilles heel for SARS-CoV, supporting nucleoside analogues as promising candidates for the treatment of COVID-19. |
|
|
Shehzadi, S, Nisar, et al |
Asian Education and Development Studies |
Public Health response| Interventions de santé publique |
This study is undertaken to examine the role of information and communication technology (ICT), e-service quality and
e-information quality towards brand image of universities by concentrating on students’ e-learning, e-word of mouth and satisfaction. Design/methodology/approach: The target population was the students of public and private universities in Pakistan. An online
questionnaire was used to collect data from the education sector of Pakistan included private and public sector |
|
|
Shekaari, A, Jafari, et al |
Journal of Molecular Structure |
Coronavirology| Coronavirologie |
we have carried out an in silico investigation on the biologically important, yet unmapped phenomenon of activity and
internal dynamics of COVID-19 main protease (Mpro) via applying finite-temperature all-atom molecular dynamics simulations. Temperature quench echoes generated by applying two successive cooling signals have therefore been analyzed in terms of the temperature-temperature
correlation function of the protease within the harmonic approximation. An exponentially decaying brand of behavior has been found for the calculated echo depth values with increasing time, which has accordingly led to a much small dephasing time of about
150 fs, revealing a significant anharmonicity and therefore an overall structural stiffness for the COVID-19 main protease. |
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|
Shelite, ThomasR, Uscanga-Palomeque, et al |
Research Square prepub |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We developed a qualitative test based on recombinase-polymerase-amplification coupled with lateral flow reading (RPA-LF)
for rapid detection of SARS-CoV-2. The RPA-LF detected SARS-CoV-2 with a limit of detection of 35.4 viral nucleocapsid (N) gene copies/µL. Additionally, the RPA-LF was able to detect 0.25-2.5 copies/µL of SARS-CoV-2 N gene containing plasmid. We evaluated
37 clinical samples using CDC’s N3, N1 and N2 RT-real-time PCR assays for SARS-CoV-2 as reference test. We found a 100% concordance between RPA-LF and RT-qPCR reference test as determined by 18/18 positive and 19/19 negative samples. |
|
|
Sherman, CB, Said, et al |
Liver Transpl |
Healthcare Response | Réponse des soins de santé |
We initially aimed to assess contemporary use of in‐person outreach and telemedicine in liver and intestinal transplantation
in the U.S. We conducted a national survey of liver and intestinal transplant programs to assess use of outreach and telemedicine from January to March of 2019. Centers with higher median MELD at transplant were more likely to utilize telemedicine (p=0.02).
During the COVID‐19 pandemic, among 55 of the 73 original responding programs (75%) from all 11 OPTN regions, telemedicine use increased from 16% to 98% and was used throughout all phases of transplant care. Telemedicine utilization was very low prior to COVID‐19
and has increased rapidly across all phases of transplant care presenting an opportunity to advocate for sustained future use. |
|
|
Shweta, Vig, S, et al |
Indian Journal of Palliative Care |
Clinical data| Données cliniques |
Case report of a 47 year old male with COVID-19 |
|
|
Siddiqui, J, Bala, et al |
AJNR Am J Neuroradiol |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We evaluated CTA as a potential COVID-19 diagnostic imaging biomarker. MATERIALS AND METHODS: This was a multicenter,
retrospective study (n = 225) including CTAs of patients with suspected acute stroke from 3 hyperacute stroke units (March-April 2020). We evaluated the reliability and accuracy of candidate diagnostic imaging biomarkers. RESULTS: Apical ground-glass opacification
was present in 22.2% (50/225) of patients. Ground-glass opacification had high interrater reliability (Fleiss κ = 0.81; 95% CI, 0.68-0.95) and, compared with reverse-transcriptase polymerase chain reaction, had good diagnostic performance (sensitivity, 75%;
specificity, 81%) on multivariate analysis. We identified a simple, reliable, and accurate COVID-19 diagnostic and prognostic imaging biomarker obtained from CTA lung apices: the presence or absence of ground-glass opacification. |
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|
Si-Mohamed, S, Chebib, et al |
Eur Respir J |
Clinical data| Données cliniques |
Our goal was to assess in vivo pulmonary microvascular involvement in patients with Covid-19 pneumonia by using DECT
and to determine whether vascular changes vary during the course of the disease. We performed a retrospective analysis of patients hospitalised for Covid-19 pneumonia (confirmed by RT-PCR for SARS-COV-2) who underwent enhanced DECT for clinical worsening of
symptoms and/or hypoxemia in search of pulmonary embolism. This pilot study has demonstrated that DECT may be used to assess pulmonary vascular involvement in vivo in patients with Covid-19 pneumonia. Two different patterns of lung perfusion were observed. |
|
|
Singh, M, Sanghavi, et al |
Indian Journal of Palliative Care |
Healthcare Response | Réponse des soins de santé |
In this study, we emphasize that in the middle of a pandemic, we need to continue serving the needs of palliative care
patients, and simultaneously, necessary steps should be taken for the prevention of the spread of virus by following guidelines, training, support, and monitoring. Of 1161 patients, male outnumbered female and the patient suffering from head-and-neck malignancy
were in the maximum number (48.7%). Our essential opioids utilization rate was 34.2%, and patients who traveled from different states were 21.6%. |
|
|
Concerns and coping strategies of persons under institutional quarantine during SARS-CoV-2
pandemic |
Singh, N, Kumar, et al |
Indian Journal of Palliative Care |
Public Health response| Interventions de santé publique |
The primary objective was to assess the prevalent concerns and coping strategies and perspectives in persons suspected
of SARS-CoV-2 infection under institutional quarantine in India during the period from April 2020 to May 2020. Its a cross-sectional observational study conducted in the National Cancer Institute, Jhajjar, India. The most common physical concern was fever
seen in 37% of respondents, followed by cough in 31% and sore throat in 29%. In terms of emotional concerns, 55.3% of respondents were worried and 43% were anxious and 33% were sad. About 80.6% of participants selected support from family and friends helped
them cope during the institutional quarantine. 57% maintained a daily routine, 70% selected praying, and 45% used music as a coping strategy. Only 2% felt that they were unable to cope. |
|
Singh, SRK, Thanikachalam, et al |
Cancers |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In our study, we describe outcomes amongst cancer patients in Detroit, a major COVID-19 hotspot with a predominant
inner-city population. We retrospectively analyzed 85 patients with active invasive cancers who were infected with COVID-19. On a multivariate analysis, factors associated with increased odds of a primary outcome included an age of >70 years versus ≤70 years
(OR 4.7, p = 0.012) and of male gender (OR 4.8, p = 0.008). Recent cancer-directed therapy was administered in 66.7% (n = 20) of ICU admissions versus 39.5% (n = 17) of general floor admissions (Chi-square p-value of 0.023). |
|
|
Siwiak, M, Szczesny, et al |
PeerJ |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The aim of this research is to provide a high-resolution global model of the pandemic that overcomes the problem of
biased country-level data on the number of infected cases. To achieve this we propose a novel SIR-type metapopulation transmission model and a set of analytically derived model parameters. We used them to perform a simulation of the disease spread with help
of the Global Epidemic and Mobility (GLEAM) framework embedding actual population densities, commute patterns and long-range travel networks. The simulation starts on 17 November 2019 with the index case (presymptomatic, yet infectious) in Wuhan, China, and
results in an accurate prediction of the number of diagnosed cases after 154 days in multiple countries across five continents. The parameters that successfully model the pandemic are: the basic reproduction number R0, 4.4; a latent non-infectious period of
1.1. days followed by 4.6 days of the presymptomatic infectious period; the probability of developing severe symptoms, 0.01; the probability of being diagnosed when presenting severe symptoms of 0.6; the probability of diagnosis for cases with mild symptoms
or asymptomatic, 0.001. Discussion: Parameters that successfully reproduce the observed number of cases indicate that both R0 and the prevalence of the virus might be underestimated. This is in concordance with the newest research on undocumented COVID-19
cases. Consequently, the actual mortality rate is putatively lower than estimated. Confirmation of the pandemic characteristic by further refinement of the model and screening tests is crucial for developing an effective strategy for the global epidemiological
crisis. |
|
|
Safe and rapid implementation of telemedicine fracture clinics: The impact of the COVID-19
pandemic |
Smith, AJ, Pfister, et al |
ANZ J Surg |
Healthcare Response | Réponse des soins de santé |
The aim of our study was to investigate whether rapid implementation of telehealth for orthopaedic fracture clinics
resulted in an increase in complications. There was no increase in complications following emergent implementation of telehealth for orthopaedic fracture clinic follow up in our institution. Patients in the telehealth group were significantly older than those
in the clinic group. |
|
32897374; Comparison of Clinical Features of COVID-19 vs Seasonal Influenza
A and B in US Children |
Song, X, Delaney, et al |
JAMA network open |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective cohort study included children who were diagnosed with laboratory-confirmed COVID-19 between March
25 and May 15, 2020, and children diagnosed with seasonal influenza between October 1, 2019, and June 6, 2020, at Children's National Hospital in the District of Columbia.Patients with COVID-19 and those with seasonal influenza had a similar hospitalization
rate (54 17%] vs 291 21%], P = .15), intensive care unit admission rate (18 6%] vs 98 7%], P = .42), and use of mechanical ventilators (10 3%] vs 27 2%], P = .17). More patients hospitalized with COVID-19 than with seasonal influenza reported fever (41 76%]
vs 159 55%], P = .005), diarrhea or vomiting (14 26%] vs 36 12%], P = .01), headache (6 11%] vs 9 3%], P = .01), body ache or myalgia (12 22%] vs 20 7%], P = .001), and chest pain (6 11%] vs 9 3%], P = .01). Differences between patients hospitalized with COVID-19
vs influenza who reported cough (24 48%] vs 90 31%], P = .05) and shortness of breath (16 30%] vs 59 20%], P = .13) were not statistically significant. |
|
Sorbara, M, Graviotto, et al |
Neurologia |
Public Health response| Interventions de santé publique |
This study aims to determine the frequency of the different types of medical consultations for neurocognitive disorders
and the predictors for requiring consultation since the beginning of the lockdown. We identified a high prevalence of behavioural disorders and caregiver burden during lockdown. Nevertheless, only 50% of respondents had sought medical consultation (by telephone
or email in 52.7% of cases). Care of people with dementia must be emphasised, guaranteeing follow-up of these patients. |
|
|
New onset of Myasthenia Gravis in a patient with COVID-19: A novel case
report and literature review |
Sriwastava, Shitiz, Tandon, et al |
Research Square prepub |
Clinical data| Données cliniques |
We report a first case MG developing secondary to COVID-19 infection in a 65-year-old woman. Two weeks prior to hospitalization,
the patient suffered from cough, fever, diarrhea and was found to be positive for COVID-19 via nasopharyngeal RT-PCR swab test. The electrodiagnostic test showed decremental response over more than 10% on repetitive nerve stimulation test of orbicularis oculi.
She tested positive for antibodies against Acetylcholine receptor (AchR). COVID-19 is known to cause release of inflammatory cytokines leading to immune-mediated damage. MG is an immune-mediated disorder caused due to molecular mimicry and autoantibodies against
the neuromuscular junction. |
|
Stub, Trine, Jong, et al |
Research Square prepub |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to investigate the impact of COVID-19 on Complementary and Alternative Medicine (CAM) providers
in Norway. During the nationwide lockdown of Norway, 38.4% of respondents were able to provide CAM treatment to their patients. To ensure that the health needs of the Norwegian population regarding CAM use are met during pandemic times like COVID-19, it is
recommended to support and train CAM providers in the development of online CAM services, as well as efficient implementation of infection prevention and control measures. |
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A case of 2019 novel coronavirus infection in a preterm infant with severe respiratory
failure |
Sumarni, N, Dewiyanti, et al |
International Journal of Pharmaceutical Research |
Clinical data| Données cliniques |
We described the first case of preterm infant SARS-CoV-2 infection in the city of Semarang, Indonesia. This case diagnosed
four weeks after birth and manifesting with severe respiratory failure requiring mechanical ventilation support and then recovered. |
|
Sümer, Ş, Ural, et al |
Klimik Dergisi |
Clinical data| Données cliniques |
In this study, we aimed to investigate clinical and laboratory characteristics of cases followed with a diagnosis of
COVID-19 in Selçuk University Faculty of Medicine Department of Infectious Diseases and Clinical Microbiology. The clinical course of COVID-19 patients varies. It is noteworthy that there is a positive correlation between the severity of pneumonia and the
increase in D-dimer and CRP levels in COVID-19. |
|
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Sun, Y, Wang, et al |
Journal of Korean Academy of Nursing |
Healthcare Response | Réponse des soins de santé |
nursing students’ understanding of the prevention of COVID-19, as well as their anxiety towards the disease and their
perception of their professional identity in the wake of the pandemic, in Zhengzhou, China. questionnaire feb 15- Mar 31. The prevalence of anxiety among nursing students was 12.4%. Male (odds ratio OR] = 2.39; 95% confidence interval CI] = 1.26~4.52), sophomores
(OR = 5.30; 95% CI = 1.61~7.45), and infrequent use of prevention measures (OR = 3.49; 95% CI = 1.16~5.19) had a significant effect on anxiety. |
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Sun, Z, Cheng, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
Due to discrimination and media literacy, middle-aged and elderly individuals have been easily reduced to marginalized
groups in the identification of rumours during a public health crisis and can easily spread rumours repeatedly, which has a negative impact on pandemic prevention and social psychology. (China, questionnaire) We found that, first, in the COVID-19 pandemic,
middle-aged and elderly adults’ willingness to re-spread rumours is positively related to their degree of believing rumours and to personal anxiety and is negatively related to their rumour-discrimination ability and to their perception of serious consequences
to rumour spreading. This suggests the importance of increasing public knowledge expertise and of reducing public panic. This also has important implications for the future design of public health policies. |
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Surleac, M, Banica, et al |
Life |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
We performed a molecular epidemiology analysis of SARS-CoV-2 viral strains circulating in Romania during the first
two months of the epidemic in order to detect mutation profiles and phylogenetic relatedness. All Romanian sequences belonged to lineage B, with a different subtype distribution between northern and southern regions (subtype B.1.5 and B.1.1). Phylogenetic
analysis suggested that the Romanian epidemic started with multiple introduction events from other European countries followed by local transmission. |
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Incorporation of telemedicine by rhinologists: The COVID-19 pandemic and beyond |
Svider, PF, Setzen, et al |
American Journal of Otolaryngology - Head and Neck Medicine and Surgery |
Healthcare Response | Réponse des soins de santé |
Our objective was to survey rhinologists and understand the extent to which telemedicine serves as a rejoinder to in-person
consultation: appreciation of relevant factors may be important in planning for present and future considerations. Most reported seeing ≤30% of typical in-person volume, with 14.8% not seeing any patients at all. 88.1% used telemedicine; 82.0% reported some
level of satisfaction with telemedicine. The vast majority utilized platforms employing audio and video (83.3%), and a plurality reported spending 5–15 min on calls. Numerous reasons were cited for the use of telemedicine, including significant public health
benefits amid the crisis (89.7%). Only 12.0% of respondents reported using telemedicine for hospital consultation. |
|
Swann, OV, Holden, et al |
The BMJ |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
651 children and young people aged less than 19 years admitted to 138 hospitals and enrolled into the International
Severe Acute Respiratory and emergency Infections Consortium (ISARIC) WHO Clinical Characterisation Protocol UK study with laboratory confirmed SARS-CoV-2. Prospective observational cohort study with rapid data gathering and near real time analysis. Setting
260 hospitals in England, Wales, and Scotland between 17 January and 3 July 2020, A systemic mucocutaneous-enteric cluster of symptoms was identified, which encompassed the symptoms for the WHO MIS-C criteria. 18% (116/632) of children were admitted to critical
care. On multivariable analysis, this was associated with age under 1 month (odds ratio 3.21, 95% confidence interval 1.36 to 7.66; P=0.008), age 10-14 years (3.23, 1.55 to 6.99; P=0.002), and black ethnicity (2.82, 1.41 to 5.57; P=0.003). Six (1%) of 627
patients died in hospital, all of whom had profound comorbidity. 11% (52/456) met the WHO MIS-C criteria, with the first patient developing symptoms in mid-March. Children meeting MIS-C criteria were older (median age 10.7 (8.3-14.1) v 1.6 (0.2-12.9) years;
P<0.001) and more likely to be of non-white ethnicity (64% (29/45) v 42% (148/355); P=0.004). Children with MIS-C were five times more likely to be admitted to critical care (73% (38/52) v 15% (62/404); P<0.001). |
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Tabernero, C, Castillo-Mayén, et al |
PLoS One |
Public Health response| Interventions de santé publique |
This research aims to analyse the relationship between motivational variables associated with physical distancing and
self-interested consumption behaviours in the first 10 days of confinement in Spain. A total of 1,324 people participated . Results showed a positive association between self- and collective efficacy and both coping behaviours analysed: a protective role
of conservation values on normative behaviours; and a negative relationship between self-transcendence values and self-interested consumption. |
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|
Tada, Takuya, Fan, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We report on an improved soluble form of ACE2, termed a "microbody" in which the ACE2 ectodomain is fused to Fc domain
3 of the immunoglobulin heavy chain. The protein is smaller than previously described ACE2-Ig Fc fusion proteins and contains an H345A mutation in the catalytic active site that inactivates the enzyme without reducing its affinity for the SARS-CoV-2 spike.The
disulfide-bonded ACE2 microbody inhibited entry of SARS-CoV-2 spike protein pseudotyped virus and live SARS-CoV-2 with a potency 10-fold higher than unmodified soluble ACE2 and retained activity even after the virus had bound to the cell. The ACE2 microbody
inhibited entry of ACE2-utilizing β coronaviruses and entry of viruses with the high infectivity variant D614G spike. |
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Tanacan, E, Aksoy Sarac, et al |
Dermatologic Therapy |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to evaluate the changing trends in dermatology clinical practice at a tertiary center during
the coronavirus disease 2019 (COVID-19) pandemic. This retrospective cohort study UK. Total number of hospital admissions have decreased from 1165 to 717. Admission rates for acne, dermatophytosis, and benign neoplasm of the skin significantly lower during
the pandemic period (P values were.02,.04, and.006, respectively). Contact dermatitis, acne accompanying dermatitis, cicatricial hair loss, lichen planus, and zona zoster infection rates were significantly higher (P values were.007, <.001,.009,.04, and.03,
respectively). Rates of biopsy and electrocautery procedures were decreased significantly (P values were <.001 and.002, respectively). The hospitalization rate was similar between the groups (P =.51). However, the use of biologic agents significantly decreased
during the pandemic period (P =.01). |
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Taneera, J, El‐huneidi, et al |
Biology |
Clinical data| Données cliniques |
In this study, microarray and RNA‐sequencing (RNA‐seq) expression data were utilized to profile the expression pattern
of ACE2, ADAM17, and TMPRSS2 in type 2 diabetic (T2D) and non‐diabetic human pancreatic islets. Our data show that pancreatic islets express all three receptors irrespective of diabetes status. . More studies are required to investigate whether variations
of ACE2 expression could explain the severity of COVID‐19 infection‐related symptoms between diabetics and non‐diabetic patients. |
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Functional data analysis: An application to COVID-19 data in the United States |
Tang, Chen, Wang, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, we use methods from the functional data analysis to look into the COVID-19 data in the US. We explore
the modes of variation of the data through a functional principal component analysis (FPCA), and study the canonical correlation between confirmed and death cases. In addition, we run a cluster analysis at the state level so as to investigate the relation
between geographical locations and the clustering structure. Lastly, we consider a functional time series model fitted to the cumulative confirmed cases in the US, and make forecasts based on the dynamic FPCA. Both point and interval forecasts are provided,
and the methods for assessing the accuracy of the forecasts are also included. |
|
Measuring the extent of stress and fear among Registered Nurses in KSA during
the COVID-19 Outbreak |
Tayyib, NA, Alsolami, et al |
Journal of Taibah University Medical Sciences |
Healthcare Response | Réponse des soins de santé |
We conducted this cross-sectional study to assess the psychological effects of fear and stress, and level of resilience
to the COVID-19 outbreak by registered nurses. In total, 314 RNs responded to our survey. The results showed that the RNs had high levels of anxiety and stress during the COVID-19 outbreak. RNs were fearful about their safety and the well-being of their families.
However, RNs felt more responsible for providing care to the COVID-19 patients. Moreover, our results signalled some predictive factors that increased RNs' level of fear, such as social media (β = 0.76, p = 0.03), exposure to trauma prior to the outbreak (β
= −0.95, p = 0.003), and readiness to care for infected patients (β = −0.21, p = 0.001). |
|
Telford, CT, Onwubiko, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This analysis sought to evaluate the timing at which mass testing took place in relation to the known presence of a
COVID-19 infection and the resulting number of infections that occurred. In 15 long-term care facility (LTCFs) that performed facility-wide testing in response to an identified case, high prevalences of additional cases in residents and staff members were
found at initial testing (28.0% and 7.4%, respectively), suggesting spread of infection had already occurred by the time the first case was identified. Prevalence was also high during follow-up, with a total of 42.4% of residents and 11.8% of staff members
infected overall in the response facilities. In comparison, 13 LTCFs conducted testing as a preventive strategy before a case was identified. Although the majority of these LTCFs identified at least one COVID-19 case, the prevalence was significantly lower
at initial testing in both residents and staff members (0.5% and 1.0%, respectively) and overall after follow-up (1.5% and 1.7%, respectively). These findings indicate that early awareness of infections might help facilities prevent potential outbreaks by
prioritizing and adhering more strictly to infection prevention and control (IPC) recommendations, resulting in fewer infections than would occur when relying on symptom-based screening. |
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Thomas, TC, Sankararaman, et al |
Journal of Critical Reviews |
Public Health response| Interventions de santé publique Economics | Économie |
This study analyses the impact of Covid 19 related announcements on NIFTY index stocks and finds out the effect of
important announcements made by WHO and Indian Government on the prices of stocks. |
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Thum DiCesare, JA, Segar, et al |
World Neurosurgery |
Public Health response| Interventions de santé publique |
We have presented the first live, cross-institutional virtual medical student subspecialty training camp to deliver
standardized neurosurgical educational content to medical students during the COVID-19 pandemic, and its results on medical student anxiety and perceptions of neurosurgery. A total of 305 medical students registered for the event from 107 unique U.S. medical
schools. Of the 305 participants, 121 (39.7%) completed the post-training survey. Of the respondents, 65.0% reported improved neurosurgical knowledge, 79.8% reported decreased anxiety about subinternships and interviews, 82.5% reported increased enthusiasm
about neurosurgery, and 100% desired a future annual virtual training camp because of the increased accessibility and decreased cost. This was especially important for students at institutions without home subspecialty programs and those with financial burdens. |
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Tomasoni, D, Adamo, et al |
J Cardiovasc Med (Hagerstown) |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to report the prevalence, clinical features and outcomes of patients with ST-elevation myocardial
infarction (STEMI) hospitalized during the COVID-19 outbreak compared with those admitted in a previous equivalent period. Eighty-five patients admitted for STEMI at a high-volume Italian centre were included. A 43% reduction in STEMI admissions was observed
during the COVID-19 outbreak compared with the previous period. Time from symptom onset to first medical contact (FMC) and time from FMC to primary percutaneous coronary intervention (PPCI) were longer in patients admitted during the COVID-19 period compared
with before 148 (79-781) versus 130 (30-185) min; P = 0.018, and 75 (59-148)] versus 45 (30-70) min; P < 0.001]. High-sensitive troponin T levels on admission were also higher. In-hospital mortality was 12% in the COVID-19 phase versus 6% in the pre-COVID-19
period. |
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Toor, R, Zamora, et al |
Hospital pharmacy |
Clinical data| Données cliniques |
One distinct feature identified in severe SARS-CoV-2 is abnormal and complex coagulation and hematologic abnormalities,
including significantly elevated D-dimer and fibrin/fibrinogen values possibly increasing morbidity and mortality in this patient population. Aggressive anticoagulation therapy with appropriate peak anti-Xa level monitoring has produce satisfactory results
at our institution. Our intent is to present a case series of our strategy to highlight the benefits of this approach. |
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Torres-Machorro, A, Anguiano-Álvarez, et al |
Thrombosis research |
Clinical data| Données cliniques |
We decided to (i) describe the clinical and ultrasonographic characteristics of patients critically ill COVID-19 who
developed deep vein thrombosis (DVT) during the stay at the ICU, and (ii) compare the characteristics of those with DVT against those who remained without DVT during the ICU stay. We performed a single-institution clinical and imaging screening to 30 critically
ill COVID-19 patients admitted to the ICU, not suspected to have any VTE neither clinically nor calculated by a modified Well's scale. |
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Torti, L, Maffei, et al |
Mediterranean Journal of Hematology and Infectious Diseases |
Clinical data| Données cliniques |
We report here a case of SARS-CoV-2 infection in a thalassemic patient and the effects of the local outbreak in hemoglobinopathic
patients which have a higher incidence of infections due to abnormalities both of innate and adaptive immunity. |
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Convalescent Plasma for the Treatment of Severe COVID-19 Infection in Cancer Patients |
Tremblay, D, Seah, et al |
Cancer Med |
Clinical data| Données cliniques |
We report a case series of patients with cancer who received convalescent plasma, an investigational therapy for severe
COVID-19. We identified 24 patients with cancer, 14 of whom had a hematological malignancy, who were treated with convalescent plasma. Fifteen patients (62.5%) were on cancer-directed treatment at the time of COVID-19 infection. After a median of hospital
duration of 9 days, 13 patients (54.2%) had been discharged home, 1 patient (4.2%) was still hospitalized, and 10 patients had died (41.7%). Non-intubated patients, particularly those on nasal cannula alone, had favorable outcomes. Three mild febrile non-hemolytic
transfusion reactions were observed. C-reactive protein significantly decreased after 3 days of treatment, while other laboratory parameters including ferritin and D-dimer remained unchanged. |
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Trevors, G, Duffy, et al |
Educational Researcher |
Public Health response| Interventions de santé publique |
Individuals generally revise their misconceptions when corrected with carefully designed educational materials. However,
early reports suggest that correcting COVID-19 misconceptions may be especially challenging, which may be due to conflicts with individuals’ moral values and emotions. This study explores the mechanisms and boundaries of correction effectiveness. Those highest
in moral concerns for group cohesion or for individual freedoms were more likely to affectively or cognitively reject corrective information. Corrections of COVID-19 misconceptions should be carefully framed to connect with the morality of recipients and anticipate
their emotional and cognitive reactions. © 2020 AERA. |
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Tsur, N, Abu-Raiya, et al |
Child Abuse and Neglect |
Public Health response| Interventions de santé publique |
To test whether exposure to child abuse (CA) is implicated in a higher risk of COVID-19-related fear and acute stress,
and whether complex posttraumatic stress disorder (CPTSD) intervenes in such processes. A convenience sample of 837 adults participated in the study during the first peak of COVID-19 in Israel. Bivariate analyses showed that participants who experienced CA
were higher than participants who did not experience CA in COVID-19 ASD (p = .032), but not in fear of COVID-19 (p = .65). Mediation analyses demonstrated two significant paths: in the first, CA was associated with elevated fear of COVID-19 (effect = .061,
.059; p < 0.05) and COVID-19 ASD (effect = .14, .084; p < 0.05) through the mediation of CPTSD; in the second path, when controlling for the mediation of CPTSD, CA was associated with reduced fear of COVID-19 (effect = −.15; p = 0.001), and COVID-19 ASD (effect
= −.12; p = 0.024). |
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Ucciferri, C, Barone, et al |
Mediterranean Journal of Hematology and Infectious Diseases |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
The aim of this study is to evaluate both efficacy and safety of pidotimod in paucisymptomatic SARS-CoV-2 patients
without any evidence of concurrent pneumonia. Twenty SARS-CoV-2 1:1 allocated patients were enrolled and resulted into two groups: Group A (Pidotimod group: Pidotimod 800mg twice a day orally per 10 days) and Group B (Control group: symptomatic regimens).
Concerning with patients’ outcome, Pidotimod group showed an earlier clinical resolution than the control one (4.10±2.18 vs 7.50±2.63 days; 95%CI: 1.13 – 5.67, S.E.: 1.08; p=0.006). |
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PMC7474895; Impacts of COVID-19 on global tourism industry: A cross-regional comparison |
Uğur, NG, Akbıyık, et al |
Tour Manag Perspect |
Public Health response| Interventions de santé publique |
This study aims to present the reactions of travelers during the pandemic trends outlined by adopting text mining techniques.
Between December 30, 2019-March 15, 2020, approximately 75,000 comments are retrieved from the TripAdvisor forums, and 23,515 cases from the US, Europe, and Asia forums are employed for analyses. The results reveal that the tourism sector is easily affected
by global crises. It is almost the same day that travelers decide to cancel or delay their trips, with the spread of the news. More in-depth analyses uncovered several topics consisted of comments on benefiting from travel insurance and refund due to the travel
cancellations. Travel insurance has become a hot topic, which may be a way of reanimating the industry by offering travel packages, including travel insurance services. |
|
Vally, Z |
Public health |
Public Health response| Interventions de santé publique |
This cross-sectional study examines the public's perceptions of the pandemic, assesses the extent to which participants
have adhered to a range of recommended health-protective behaviours to prevent infection and evaluates whether anxiety about COVID-19 or perceptions related to the pandemic are associated with greater adherence to these behaviours. A total of 634 participants
were included in the analysis. A total of 44.8% of the sample reported adherence to all the examined behaviours. Participants who were employed, those with some or completed postsecondary education and those with a chronic illness diagnosis were more likely
to adhere to the precautionary behaviours. The perception of personal risk of infection (OR: 0.83, 95% CI: 0.71–0.98), perception of substantial life consequences of becoming infected (OR: 0.87, 95% CI: 0.75–0.10) and the perception that the public health
information was clear (OR: 0.69, 95% CI: 0.57–0.83) were all positively related with behavioural adherence. The health-protective behaviours were all perceived as being highly efficacious in combating infection, and these efficacy ratings were also positively
associated with greater behavioural adherence (OR: 0.41–0.77). Having read the official government public health nformation was related to greater behavioural adherence (OR: 0.37, 95% CI: 0.23–0.61). |
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Valotti, G, Cristofoli, et al |
Mecosan |
Public health interventions*| Interventions de santé publique Healthcare Response |
Réponse des soins de santé |
We analyze how the same type of public intervention (the transformation of a convention center into a hospital for
Covid-19 patients) has occurred in three different contexts (Wuhan, New York and Milan). We highlight which models has led to a timely and efficient public intervention aimed at fighting Covid-19 local epidemic. The comparative analysis reveals that there
is no single path to success: according to different contextual conditions, different factors are fundamental to ensure government timeliness and efficiency. We argue that the same factors are important also in situations of “ordinary emergency”, which normally
occurs as, physiologically, governments have to cope with unlimited needs and scarce resources availability. Copyright © FrancoAngeli. |
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Van Praet, JT, Coene, et al |
Infection |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
A subset of patients with Covid-19 presents with negative RT-PCR screening but suspect CT findings. Using four commercially
available anti-SARS-CoV-2 IgG immuno-assays, we found this subset constituted 9.2% of all consecutively admitted outpatients with Covid-19 in our hospital. Clinical specificity for Covid-19 of some N protein-based immuno-assays was suboptimal, as positive
results were observed in control patients with recent common human coronavirus, influenza B and adenovirus infections. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature. |
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Vendola, N, stampini, et al |
European Journal of Obstetrics and Gynecology and Reproductive Biology |
Transmission Clinical data| Données cliniques |
To date there is no certainty if the mother transmits serological protection through the placenta. We describe two
cases of mother with positive IGG on peripherical blood test, and the evidence IGGtesting positive in umbilical cord soon after delivery. In our cases SARS-CoV-19 IgG were detected in the maternal serum, and specific antibodies were detected in neonatal bloodserum
samples with elevated concentrations, similar to the IgG concentrations of their respective mothers, despite the babies’ throat swab were negative. |
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Prediction of COVID-19 outbreaks using google trends in India: A retrospective analysis |
Venkatesh, U, Gandhi, et al |
Healthcare Informatics Research |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique |
It is essential to explore the methods and resources that might predict the case numbers expected and identify the
locations of outbreaks. Hence, we analyzed the potential use of Google Trends (GT) in predicting the COVID-19 outbreak in India. “Coronavirus” and “corona” were the terms most commonly used by Internet surfers in India. Correlation for the GTs of the search
terms “coronavirus” and “corona” was high (r > 0.7) with the daily cumulative and new COVID-19 cases for a lag period ranging from 9 to 21 days. The maximum lag period for predicting COVID-19 cases was found to be with the News search for the term “coronavirus”,
with 21 days, i.e., the search volume for “coronavirus” peaked 21 days before the peak number of cases reported by the disease surveillance system. |
|
Verter, EE, Coady, et al |
Retina Today |
Healthcare Response | Réponse des soins de santé |
Seeking to understand the impact of COVID-19 on retina practices and on patients with delayed maintenance intravitreal
injections, we conducted a survey. From May 16 to May 23, 139 practicing retinal specialists responded to the survey. Of the respondents, 84% (117/139) were from United States. Our survey demonstrated that many retina specialists saw a decline in clinical
volume during the pandemic. The reasons for delaying care were many, but the main factor was fear of becoming infected with SARS-CoV-2. Most survey respondents were optimistic in terms of clinical volume recovery and said they believed that their volume would
return to pre-pandemic baseline within 1 year. Only 6% said they believed the decline would be permanent. |
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Supply chain disruptions in the context of early stages of the global COVID-19
outbreak |
Veselovská, L |
Problems and Perspectives in Management |
Public Health response| Interventions de santé publique Economics | Économie |
This paper aims to assess the initial response undertaken by Central European companies in the early stages of the
outbreak. The survey was conducted as a research method to collect data from a large number of companies. Since it takes time to assess long-term effects of the pandemic and related measures, various changes in supply chains are examined as the early results
of the COVID-19 crisis and measures implemented by companies. The changes in operating volumes were identified as the most commonly used measures to accommodate new market developments. However, developing the new supply chain partnership was the most successful
measure. This measure correlates with an increase in revenues and an increase in the number of customers. In some cases, disruptions in supply chains had positive effects on revenues as a reaction to the COVID-19 epidemic outbreak. Cross-country examinations
found that all Polish companies implemented at least one new measure to tackle this crisis. Nearly 20% of Slovak companies and nearly 30% of Czech companies made no changes in their operations during the early stages of the crisis. However, overall, the supply
chains in Central European countries turned out to be quite resilient, since most companies managed to survive the supply chain disruptions and in some cases even show signs of overcoming them completely. |
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Short-term economic impact of COVID-19 on Spanish small ruminant flocks |
Vidaurreta, I, de la Fe, et al |
Animals |
Public Health response| Interventions de santé publique Economics | Économie |
Although small ruminants are not sanitary affected by this virus, the short-term economic impact derived by COVID-19
on Spanish flocks is estimated in this study, using data provided by producers and two major slaughterhouses. In conclusion, data evidenced a considerable negative economic impact on Spanish small ruminant flocks, throughout the first 60 days after COVID-19’s
pandemic declaration. |
|
Vispi, M, Corradin, et al |
Dermatology Reports |
Epidemiology| Épidémiologie |
The Dermatology Units in Grosseto and Pordenone simultaneously carried out a data collection by remote-conducted visits,
evaluating the incidence of COVID-19 in psoriatic patients. Only 1 patient (close contact of a case) as part of the psoriasis analyzed group was tested and turned out to be positive for SARS-CoV-2, developing no symptoms during the observation period. The
collected information may suggest that psoriasis, biotechnologically treated or not, cannot promote or aggravate the clinical trend of the SARS-CoV-2 infection, hence stopping systemic therapy in negative or clinically free SARS-CoV-2 patients is not recommended
in general. |
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A granulocytic signature identifies COVID-19 and its severity |
Vitte, J, Diallo, et al |
J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
We aimed to identify previously unreported immune markers able to discriminate COVID-19 patients from healthy controls
and to predict mild and severe disease. An observational, prospective, multicentric study was conducted in patients with confirmed COVID-19: mild/moderate (n=7) and severe (n=19). Granulocytic (neutrophil, eosinophil and basophil) markers were enriched during
COVID-19 and discriminated between mild and severe patients. Increased counts of CD15 +CD16 + neutrophils, decreased granulocytic expression of integrin CD11b, and Th2-related CRTH2 downregulation in eosinophils and basophils established a COVID-19 signature.
Severity was associated with the emergence of PDL1 checkpoint expression in basophils and eosinophils. This granulocytic signature was accompanied by monocyte and lymphocyte immunoparalysis. Correlation with validated clinical scores supported pathophysiological
relevance. |
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Vizcaychipi, MP, Shovlin, et al |
Brazilian Journal of Infectious Diseases |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Our goal was to evaluate if traffic-light driven personalized care for COVID-19 was associated with improved survival
in acute hospital settings. Personalized early interventions were associated with a 33% reduction in early mortality. We suggest benefit predominantly resulted from early triggers to review/enhance anticoagulation management, without exposing lower-risk patients
to potential risks of full anticoagulation therapy. |
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Wang, C, Tian, et al |
International Journal of Biological Sciences |
Public Health response| Interventions de santé publique |
This is one of very limited studies focusing on international migrants’ COVID-19 prevention knowledge and attitudes
during the epidemic. The sample included 1,426 international migrants representing 77 countries and 6 continents. Just half of the sample, 730/1426 (51.2%) had a good level of knowledge and 656/1426 (46.0%) had a positive attitude towards the COVID-19 epidemic.
Knowledge was associated with receiving information through social media (aOR: 2.0, 95% CI: 1.2-3.2), the Internet (aOR: 1.4, 95% CI: 1.2-1.8), the community (aOR: 1.5, 95% CI: 1.2-1.8), and encountering language barriers when receiving medical services (aOR:
0.8, 95% CI: 0.7-1.0). Positive attitude was associated with the level of trust in various Chinese institutions and groups. |
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32888705; Contamination of SARS-CoV-2 RT-PCR probes at the oligonucleotide manufacturer |
Wang, CYT, Buckley, et al |
Pathology |
Coronavirology| Coronavirologie |
Here we report contamination of a SARS-CoV-2 probe that our evidence suggests occurred at the oligonucleotide manufacturer,
and was due to the manufacturer synthesising full length control oligonucleotides (spanning from the forward to reverse primers) in parallel with our probe orders. |
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Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and coronaviruses by depleting membrane
cholesterol |
Wang, S, Li, et al |
Embo j |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Here, we report that one of the interferon-stimulated genes (ISGs), cholesterol 25-hydroxylase (CH25H), is induced
by SARS-CoV-2 infection in vitro and in COVID-19 patients. CH25H converts cholesterol to 25-hydrocholesterol (25HC) and 25HC shows broad anti-coronavirus activity by blocking membrane fusion. Furthermore, 25HC inhibits USA-WA1/2020 SARS-CoV-2 infection in
lung epithelial cells and viral entry in human lung organoids. Mechanistically, 25HC inhibits viral membrane fusion by activating the ER-localized acyl-Co A:cholesterol acyltransferase (ACAT) which leads to the depletion of accessible cholesterol from the
plasma membrane. Altogether, our results shed light on a potentially broad antiviral mechanism by 25HC through depleting accessible cholesterol on the plasma membrane to suppress virus-cell fusion. Since 25HC is a natural product with no known toxicity at
effective concentrations, it provides a potential therapeutic candidate for COVID-19 and emerging viral diseases in the future. |
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Analysis of the influence of traffic control measures on the prevention and
control of COVID-19 |
Wang, W, Zhu, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This paper analyzed the process of the COVID-19 epidemic spread through transportation channels at home and abroad,
and made a comparative analysis of the epidemic development before and after taking traffic control measures in different countries around the world. After clarifying the role of transportation channels in the epidemic spread, we simulated the epidemic development
under different traffic control measures based on the SEIR disease dynamics model. The results show that, without traffic control measures, the peak value of infected people will appear earlier. If strict traffic control measures are taken, the simulated lines
of the latent and infected people will almost disappear, and the epidemic will soon stop. Our research results provide a theoretical basis for formulating reasonable traffic control measures. |
|
Wang, X, Tu, et al |
Cardiovascular Diagnosis and Therapy |
Clinical data| Données cliniques |
In the first severe case of COVID-19 in Shenzhen city, the authors found that in addition to the typical clinical manifestations,
their patient presented hemoptysis, refractory hypoxemia and pulmonary fibrosis-like changes on computed tomography (CT) involving alveoli and pulmonary interstitium in the early stage and acute pulmonary hypertension and right heart failure in the later stage,
which were not completely justified by myocarditis, acute respiratory distress syndrome (ARDS), pulmonary fibrosis and high PEEP level. The lung compliance deterioration of this patient was not as serious as expected, indicating classic ARDS was not existed.
Simultaneously, the first autopsy report of COVID-19 in China showed normal-structured alveoli and massive thick excretion in the airway. Speculated that the virus not only attacked alveolar epithelial cells, but also affected pulmonary vascular endothelial
cells. Imbalance in the ACE2-RAAS- bradykinin axis and the cytokine storm could be an important mechanism leading to pathophysiological changes in pulmonary vascular and secondary refractory hypoxemia. Pulmonary vasculitis or capillaritis associated to immune
damage and an inflammatory storm could exist in COVID-19 because of ground-glass opacities in the subpleural area, which are similar to connective tissue disease associated interstitial lung disease (CTD-ILD). |
|
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Wang, Z, Zhang, et al |
Medical Science Monitor |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study was designed to investigate effects of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II
receptor blockers (ARBs) on clinical outcomes of COVID-19 patients and to assess the safety of ACEIs/ARBs medication. Included 210 patients and allocated them to ACEIs/ARBs (n=81; 46.91% males) or non-ACEIs/ARBs (n=129; 48.06% males) groups. The median age
was 68 interquartile range (IQR) 61.5–76] and 66 (IQR 59–72.5) years, respectively. General comparison showed mortality in the ACEIs/ARBs group was higher (8.64% vs. 3.88%) but the difference was not significant (P=0.148). ACEIs/ARBs was associated with significantly
more cases 7-cate-gorical ordinal scale >2 at discharge, more cases requiring Intensive Care Unit (ICU) stay, and increased values and ratio of days that blood pressure (BP) was above normal range (P<0.05). PSM analysis showed no significant difference in
mortality, cumulative survival rate, or other clinical outcomes such as length of in-hospital/ ICU stay, BP fluctuations, or ratio of adverse events between groups after adjustment for confounding parameters on admission. |
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|
Wen, F, Ma, et al |
Acta Psychologica Sinica |
Public Health response| Interventions de santé publique |
This study carried out a survey of the psychological state of Chinese people and their evaluation of Wuhan residents
during the epidemic period since the day of Wuhan’s citywide lockdown. The purpose of this work was to explore differences in degree of concern, risk perception, and anxiety response among regions affected by COVID-19 to different degrees. The survey involved
two angles, the “actor” angle, in which participants evaluated their own psychological states, and the “bystander” angle, in which participants evaluated other Wuhan citizens’ psychological states. Called these Study 1 and Study 2. Study1 explored the psychological
state of residents themselves and the results were consistent with the ripple effect to some extent within the epidemic period, which is the opposite pattern of the psychological typhoon eye. The residents who lived near the hardest-hit areas showed significantly
higher risk perception and anxiety. Study 2 explored how people from different areas evaluated Wuhan residents’ psychological state. The results of Study 2 did show a replicated psychological typhoon eye effect in terms of anxiety, and number of psychological
workers and doctors residents needed. However, when it came to risk cognition, residents in low-risk areas rated Wuhan citizens’ risk cognition as significantly lower than people in high-risk areas did, which generally manifested as a ripple effect. |
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|
Wilke, NG, Howard, et al |
Child Abuse and Neglect |
Public Health response| Interventions de santé publique |
The goal of the present study was to better understand the scope and characteristics of rapid return, and to provide
data-informed recommendations for service providers working with this population. Data revealed that rapid return was characterized by compressed timelines that did not allow for adequate child and family assessment and preparation. However, all respondents
indicated they believed at least some families would be able to remain intact safely with appropriate support. Primary concerns for children and families related to unresolved antecedents to separation, lack of economic capacity, limited monitoring, and lack
of access to education. |
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|
Witteveen, D |
Res Soc Stratif Mobil |
Public Health response| Interventions de santé publique Economics | Économie |
To mitigate the detrimental effects on the financial stress of employees and households, the UK government implemented
a furlough scheme that temporarily secured earnings up to 80 percent of regular pay. Other employees were at risk of reduced work hours or permanent job loss. Using data from the UK Household Longitudinal Study COVID-19 Supplement, this study examines the
extent to which different earnings groups and sociodemographic groups (gender, race/ethnicity, class background) became exposed to economic hardship between March and May of 2020. Results indicate that lower earnings groups were more than twice as likely to
experience economic hardship relative to top quintile earners. Furthermore, among pre-COVID employed individuals, men and whites had a lower probability of being furloughed or dismissed from work. |
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Wlodarczyk, JR, Alicuben, et al |
American Journal of Surgery |
Healthcare Response | Réponse des soins de santé |
This study presents a novel online curriculum for incorporation into traditional surgical educational programs. 77%
and 80% of clinical residents attended faculty lectures and resident led topic discussions as compared to 66% and 48% attending traditional in-person grand rounds and SCORE curriculum (both p > 0.05). 71.9% of residents and 16.6% of faculty reported improved
resident participation while none reported decreased levels of participation (p < 0.001). 87.1% of residents and 66.7% of faculty preferred the online curriculum (p = 0.374). Completed ABSITE practice questions per resident increased from 21 to 31 questions/week
(p = 0.541). |
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Xia, M, Duan, et al |
International Journal of Mental Health Promotion |
Public Health response| Interventions de santé publique |
The purpose of this study was to investigate the stress and coping strategy of Chinese International Students (CISs)
during the epidemic, and to explore the relationship between identification with Chinese cultural beliefs and coping strategies, positive experience, negative emotion and need for psychological support. The results showed that CISs experienced an above moderate
level of direct and indirect pandemic related stress. To cope with the stress, participants valued active coping and making self-adjustment. The regression analysis shows ICCB could positively predict coping strategy and positive experience, and negatively
predict negative emotions. ICCB is also positively related to the need for psychological support. |
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32895171; Clinical features of severe or critical ill patients with COVID-19 |
Xie, W, Zhu, et al |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study analyzed the clinical features of severe or critical ill adult patients with coronavirus disease (COVID-19).
Of the 75 patients with COVID-19 pneumonia, 41 were male (54.67%) and 34 were female (45.33%) with a mean age of 67.53 ±12.37 years; 43 patients had severe and 32 had critical COVID-19, and 49.3% of the patients had underlying diseases. The main clinical manifestations
included fever (78.67%) and coughing (70.67%). Compared with the severe patients, the critically ill patients had higher proportions of patients over 60 years old with elevated white blood cell count, increased prothrombin time, and higher levels of hsCRP,
PCT, D-dimer, ALT, LDH, cTnI and NT-proBNP. Univariate logistic regression analysis showed that an age over 60 years, leukocytosis, hs-CRP elevation, prolonged prothrombin time, and increased levels of D-dimer, NT-proBNP and cTnI were associated with severe
COVID-19. Multivariate logistic regression showed that an age over 60 years (OR=8.165, 95%CI: 1.483-45.576, P=0.017), prolonged prothrombin time (OR=7.516, 95%CI: 2.568-21.998, P=0.006) and elevated NT-proBNP (OR=6.194, 95%CI: 1.305-29.404, P=0.022) were independent
risk factors for critical type of COVID-19. |
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A case of COVID-19 complicated by Stevens-Johnson syndrome-like skin lesions |
Xie, X, Chen, et al |
Chinese Journal of Dermatology |
Clinical data| Données cliniques |
could not find the paper |
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Virtual grand rounds as a novel means for applicants and programs to connect
in the era of COVID-19 |
Xu, L, Ambinder, et al |
American Journal of Surgery |
Healthcare Response | Réponse des soins de santé |
This study investigated the feasibility and utility of video conferencing technology (VCT) as an opportunity for applicants
to interact with faculty from outside programs. 17 students completed the survey, reporting a 100% satisfaction rate with VGR. A majority felt this was a useful way to learn about outside programs. 85 physicians completed the faculty survey, with nearly half
feeling confident in their ability to evaluate the applicant. Video transcription data shows sessions were interactive with minimal distractions. |
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An epidemic model to predict the effect of infection on
population of India by COVID-19 corona virus |
Yadav, R, Singh, et al |
Plant Archives |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The Covid-19 outbreaks in India is a great concern. A detailed scientific analysis of this epidemic is still to come,
but now it is necessary to calculate the parameters of the pandemic dynamics in order to create the appropriate quarantine place, to estimate the number of beds in hospitals, etc. In this paper, we have discussed Polynomials Approximation Model for estimation
of number of infected peoples in India. © 2020 Plant Archives. All rights reserved. |
|
Yan, H, Zou, et al |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study explored the target, signaling pathways and their biological functions of QingfeiPaidu Decoction in the
treatment of COVID-19 based on network pharmacology and molecular docking technology. Identified 163 active ingredients, including MOL004798, MOL000519, MOL004824, MOL000554, MOL010428, and MOL013443, from 18 drugs in QingfeiPaidu decoction (such as EphedraeHerba,
PinelliaeRhizoma, GlycyrrhizaeRadixEtRhiizoma, FarfaraeFlos, AsterisRadixEtRhizoma and AurantiiFructusImmaturus). These ingredients activate renin-angiotensin system signaling pathway and apoptosis signaling pathway by regulating 10 protein targets (ACE, ACE2,
AGTR1, FURIN, TNF, CASP3, CASP6, DPP4, MCL1 and POLD1) to execute 42 biological functions such as renin-angiotensin regulation of blood volume and systemic arterial blood pressure to treat COVID-19. The results of preliminary molecular docking showed that
MOL000519 (from PinelliaeRhizoma), MOL000554 (from FarfaraeFlos), MOL004798 (from EphedraeHerba), MOL004824 (from GlycyrrhizaeRadixEtRhiizoma), MOL010428 (from AsterisRadixEtRhizoma), and MOL013443 (from AurantiiFructusImmaturus) had good affinity with SARS-CoV-2
3CL hydrolase to form complexes with stable conformations and high binding activity (binding energy ≤- 5 kJ/mol). |
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Yan, L, Mir, et al |
Archives of Pathology & Laboratory Medicine |
Clinical data| Données cliniques |
This case presents a clinical-pathologic correlation report of a previously healthy Hispanic woman with laboratory-confirmed
COVID-19 who had typical features of acute respiratory distress syndrome (ARDS) and also showed cardiac abnormalities thought to represent fulminant viral myocarditis. Congruent with the ARDS clinical impression, autopsy findings were remarkable for extensive
and markedly severe acute lung injury consistent with viral pneumonia, characterized by diffuse alveolar damage, pulmonary infarction, severe pulmonary edema, desquamation of pneumocytes with intra-alveolar aggregation, and pneumocyte morphologic alterations
suggestive of viral cytopathic effect. However, there was incongruence between the clinical impression and the cardiovascular pathology findings in that viral myocarditis was not detected on histopathologic evaluation. |
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Yang, G, Xiao, et al |
Risk Management and Healthcare Policy |
Clinical data| Données cliniques Public Health response| Interventions de santé publique |
This research explored the effect of adverse childhood experience (ACE) on suicide ideation in young cancer patients
during the COVID-19 pandemic. Selfreported questionnaires analyzed the mediating effects of sleep quality, anxiety symptoms, and inflammatory conditions between ACE and suicide ideation. ACE was positively related to anxiety symptoms, CRP levels, and suicide
ideation, and negatively related to sleep quality. Anxiety symptoms and CRP levels were positively related to suicide ideation, while sleep quality was negatively related to suicide ideation. Anxiety symptoms were positively related to CRP levels but negatively
related to sleep quality. From these results, we found ACE affected suicide ideation directly and was mediated by roles sleep quality, anxiety symptom and CRP. |
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Yang, S, Shan, et al |
J Med Virol |
Coronavirology| Coronavirologie |
Pangolin metagenomic data obtained from public databases were used to assemble partial or complete viral genomes showing
genetic relationship to SARS-CoV-2, Sendai virus, flavivirus, picornavirus, parvovirus and genomovirus, respectively. Most of these virus genomes showed genomic recombination signals. Phylogeny based on the SARS-CoV-2-related virus sequences assembled in this
study and those recently published indicated that pangolin SARS-CoV-2-related viruses were clustered into two sub-lineages according to geographic sampling sites. These findings suggest the need for further pangolin samples, from different countries, to be
collected and analyzed for coronavirus in order to elucidate whether pangolins are intermittent hosts for SARS-CoV-2. This article is protected by copyright. All rights reserved. |
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Yang, T, Shi, et al |
Chinese Journal of Dermatology |
Clinical data| Données cliniques |
could not find the paper |
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Yang, X |
British Food Journal |
Public Health response| Interventions de santé publique |
This study enlightens the potential effects of the pandemic on young adults' willingness to avoid game meat consumption
as well as to purchase animal welfare products. Using a Chinese sample, results indicated that food safety concern – triggered by risk perception and anxiety – negatively affected willingness to buy animal welfare products. Perceived responsibility of marketers'
change positively relates to people's willingness to avoid game meat and to buy animal welfare products, while the latter is also positively related to perceived governmental responsibility. |
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Challenges of tracheostomy in COVID-19 patients in a tertiary centre in inner city
London |
Yeung, E, Hopkins, et al |
International journal of oral and maxillofacial surgery |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study reviewed the tracheostomy provision, techniques, and outcomes for a single-centre prospective cohort during
the resource-pressured COVID-19 period. Seventy-two of 176 patients underwent tracheostomy at a median 17 days: 44 surgical (open), 28 percutaneous. Their median age was 58 years, the male to female ratio was 2.4:1, 75.1% were of BAME backgrounds, 76% had
a BMI ≥ 25 kg/m2, and 65% had ≥2 major co-morbidities. Seventy-nine percent of patients were weaned from sedation at a median 2 days, 61% were weaned from mechanical ventilation at a median 10 days, 39% were discharged from the ICU at a median 11.5 days, and
19.4% were discharged home at a median 24 days. All patients survived the procedure. The mortality rate was 9.7% at a median 12 days. No clinician reported COVID-19 symptoms within 14 days of the procedure. The role of tracheostomy in COVID-19 is currently
unclear. |
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Ct imaging features during disease progression of 2019 novel coronavirus (Covid-19)
pneumonia |
Yu, N, Yu, et al |
Iranian Journal of Radiology |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study described the characteristics of CT in patients with 2019 novel coronavirus (COVID-19) pneumonia and their
changes during disease progression. The initial CTs of 61 patients were obtained during 1 to 11 days after the onset. The main CT pattern of initial CT obtained during 1-3 days after the symptom onset was single (7/23, 35%) or multiple ground-glass opacity
(GGO, 8/23, 35%). At 4-7 days after the symptom onset, the main imaging features were crazy paving GGO mixed with partial consolidation pattern (15/32, 47%). At 8-11 days after the symptom onset, the CT images showed consolidation pattern (3/6, 50%). A total
of 35 follow up CTs were collected. The mean interval time between each follow up CT was 3 ± 2 days. The CT patterns also changed with the evolution of the disease: the features of GGO manifested at the early stage (1-3d). The crazy paving GGO pattern, consolidation
pattern and mixed with partial consolidation pattern were found 4 to 14 days after the onset. In the absorption stage (15-24d), both density and extent of lesions were reduced. |
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Anti-COVID-19 multi-epitope vaccine designs employing global viral genome sequences |
Zaheer, T, Waseem, et al |
PeerJ |
Clinical data| Données cliniques Therapeutics| Thérapeutique Immunology | Immunologie |
This study aimed to cover the diversity of SARS-CoV-2 strains reported from all over the world and to design a broad-spectrum
multi-epitope vaccine using an immunoinformatics approach. The designed multi-epitopes were found to be antigenic and non-allergenic. Both multi-epitopes were stable and predicted to be soluble in an Escherichia coli expression system. The molecular docking
with TLR8 also demonstrated that they have a strong binding affinity and immunogenic potential. These in silico analyses suggest that the proposed multi-epitope vaccine can effectively evoke an immune response. |
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Knowledge and awareness of community toward COVID-19 in Jordan: A cross-sectional study |
Zaid, AA, Barakat, et al |
Systematic Reviews in Pharmacy |
Public Health response| Interventions de santé publique |
The aim of the study is to determine the knowledge and awareness of COVID-19 among the general public in Jordan. Participants
generally had satisfactory knowledge of the main mode of disease transmission and the common symptoms of COVID-19, as half of the participants confirmed that transmission is via droplets from sneezing or coughing and from contaminated surfaces. In addition,
most (77%) of the respondents stated that more than one category could be at high risk of complications from COVID-19, including the elderly, people with weak immune systems, those with heart problems, and diabetic patients. However, a substantial proportion
of participants had misconceptions about how to prevent infection. For instance, about 80% of participants thought that wearing a mask was effective in protecting them from acquiring COVID-19. |
|
Zaidi, S, Rizwan, et al |
J Public Health (Oxf) |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
This cross-sectional study examined the serological evidence of SARS-CoV2 antibodies for a better estimation of the
actual number of infected patients to limit the disease spread and to get an idea of herd immunity. The study included healthcare workers (HCWs), community and industrial workers. The anti-SARS-CoV-2 test was performed by electrochemiluminescence immunoassay
analyzer. A total of 1675 samples have been received from three groups of population. The percentage positivity for industrial employees is high (50.3%) for HCW (13.2%) and community population (34%).Total percentage for positive antibodies result is ~36%
far from herd immunity that needs to be at least 60-70% in population.. |
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Torsade de pointes caused by hydroxychloroquine use in a patient with a severe
form of COVID-19 |
Zarrouki, Y, Rebahi, et al |
Southern African Journal of Critical Care |
Clinical data| Données cliniques |
We report the case of a previously healthy patient who was severely affected by COVID-19 and developed torsade de pointes
after hydroxychloroquine-Azithromycin administration. Critically ill COVID-19 patients have multiple abnormalities that lead to an unsteady state in heart electricity, and can potentiate hydroxychloroquine cardiotoxicity. In light of this clinical observation,
and until the efficacy of this association is proven, we plead against its use in critically ill COVID-19 patients. © 2020 South African Medical Association. All rights reserved. |
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Zhang, A, Li, et al |
Zhongguo yi xue ke xue yuan xue bao.Acta Academiae Medicinae Sinicae |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study explored the optimal therapy time for the treatment of severe coronavirus disease 2019(COVID-19)by traditional
Chinese medicine(TCM)and its influence on the therapeutic effect and prognosis. On day 14,the oxygenation index was 292.5(252.0,351.0)mmHg in the early intervention group,which was significantly higher than that in the late intervention group 246.0(170.0,292.5)mmHg](P=0.005).The
length of hospital stay (18.56±1.11)d vs.(24.87±1.64)d,P=0.001],duration of ICU stay (14.12±0.91)d vs.(20.00±1.53)d,P=0.000] and time to negativity (16.77±1.04)d vs.(22.48±1.66)d,P=0.001] in the early intervention group were significantly shorter than those
in the late intervention group.The intubation rate(7.3%)in the early intervention group was significantly lower than that in the late intervention group(30.4%)(P=0.028). Early TCM therapy within three days after a diagnosis of severe COVID-19 can shorten
the length of hospital stay,duration of ICU stay,and time to negativity and decrease intubation rate. |
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Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2
In Vitro |
Zhang, L, Liu, et al |
Virologica Sinica |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study evaluated the antiviral efficacy of lopinavir/ritonavir along with other two viral protease inhibitors
in vitro, and discussed the possible inhibitory mechanism in silico. The in vitro to in vivo extrapolation was carried out to assess whether lopinavir/ritonavir could be effective in clinical. Among the four tested compounds, lopinavir showed the best inhibitory
effect against the novel coronavirus infection. However, further in vitro to in vivo extrapolation of pharmacokinetics suggested that lopinavir/ritonavir could not reach effective concentration under standard dosing regimen marketed as Kaletra®, contained
lopinavir/ritonavir (200 mg/50 mg) tablets, recommended dosage is 400 mg/10 mg (2 tablets) twice daily]. |
|
Zhang, X, Li, et al |
PeerJ |
Public Health response| Interventions de santé publique |
This study conducted a survey using a questionnaire on scientific research progress and psychological stress during
the COVID-19 epidemic. Of the 251 participants, 76.9% indicated that their research was affected by the COVID-19 outbreak, and participants who were affected by the outbreak had higher stress levels than those who were not affected. Participants who conducted
COVID-19 research and indicated concern that they would fail to finish the research on time were more likely to indicate high levels of stress. Respondents indicated that extending deadlines (64.1%), receiving support from superiors for research (51.8%), and
increasing benefits for researchers (51.0%) would likely relieve outbreak-related stress. |
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Zhao, N, Zhou, et al |
Appl Psychol Health Well Being |
Public Health response| Interventions de santé publique |
This study investigated the associations of COVID-19-related social media use with mental health outcomes and uncovered
potential mechanisms underlying the links. Results from regression analyses indicated that a higher level of social media use was associated with worse mental health. More exposure to disaster news via social media was associated with greater depression for
participants with high (but not low) levels of the disaster stressor. Moreover, path analysis showed negative affect mediated the relationship of social media use and mental health. |
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Zhao, Y, Wang, et al |
Medical Science Monitor |
Public Health response| Interventions de santé publique |
This study used an online questionnaires to evaluate the factors associated with anxiety and depression in Chinese
visiting scholars in the United States during the COVID-19 pandemic. Of these 311 visiting scholars, 69 (22.2%) reported no symptoms of anxiety or depression, whereas 63 (20.3%) reported severe anxiety and 67 (21.5%) reported severe depression. Risk of anxiety
was 93% higher in visiting scholars with than without accompanying parents in the US (odds ratio OR], 1.93; 95% confidence interval CI], 1.01–3.68) and was 1.72-fold (95% CI, 1.04–2.84) higher in those experiencing stress about family members with COVID-19.
Stresses about personal security and return to China on schedule were associated with 1.73-fold (95% CI, 1.03–2.92) and 3.00-fold (95% CI, 1.51–5.95) higher risks of anxiety, respectively. Risks of depression were 1.86-fold (95% CI, 1.14–3.05), 1.84-fold (95%
CI, 1.10–3.07), and 3.45-fold (95% CI, 1.72–6.92) higher in visiting Chinese scholars who were than were not experiencing stresses about financial support, personal security and return to China on schedule, respectively. |
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|
Zheng, F, Xu, et al |
Research of Environmental Sciences |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
In order to study the potential risks and protection measures against exposure for the workers in the collection, transportation,
temporary storage, and disposal of medical waste, ninety staff members from a typical medical waste disposal center in Zhejiang Province were selected as the research objects to study the personal protection level of staff in different types of work, as well
as the influence of items or locations at risk of infection on their choice of protective measures. The results show that among the 90 surveyed people, 98.9% of the staff wore medical respirators or full-face masks and half-masks during the work, 87.5% of
the staff wore work clothes, 79.6% of the staff wore labor protection cap, 64.8% of workers chose to wear rubber gloves and protective boots for protection, and goggles (55.7%) and protective clothing (33.0%) were also worn when they were closely contact with
medical waste. At the end of a single task, 100% of the respondents chose to wash their hands with running water, soap, quick disinfectant or 0.3%-0.5% iodophor disinfectant or bathe, and 94.3% of the respondents disinfected their personal work items; all
respondents would take protective measures such as washing hands, disinfecting items, ventilating after returning home. |
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|
Zheng, X, Yang, et al |
Clin J Am Soc Nephrol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study assessed the characteristics of kidney injury and its association with disease progression and death of
patients with coronavirus disease 2019. A total of 555 patients were enrolled; 42% of the cases (229 of 549) were detected with any kidney injury, 33% of the cases (174 of 520) were detected with proteinuria, 22% of the cases (112 of 520) were detected with
hematuria, and 6% of the cases (29 of 520) were detected with AKI. Of the 29 patients with AKI, 21 cases were recognized as in-hospital AKI, and eight were recognized as prehospital AKI. Altogether, 27 (5%) patients died at the end of follow-up. The death
rate was 11% (20 of 174) in patients with proteinuria, 16% (18 of 112) in patients with hematuria, and 41% (12 of 29) in the AKI settings. Multivariable Cox regression analysis showed that proteinuria , hematuria, and in-hospital AKI were associated with death.
Among the 520 patients with noncritical illness at admission, proteinuria and hematuria were found to be associated with progression to critical illness during the study period. |
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Zhou, W, Qin, et al |
International Journal of Medical Sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study established prognostic scoring models based on comorbidities and other clinical information for severe and
critical patients with COVID-19. The mean hospital length of stay (LOS) of the COVID-19 patients was 22.82 ± 12.32 days; 19 patients (37.3%) were hospitalized for more than 24 days. Multivariate analysis identified older age (OR 1.064, P = 0.018, 95%CI 1.011–1.121)
and smoking (OR 3.696, P = 0.080, 95%CI 0.856–15.955) as positive predictors of a long LOS. There were significant trends for increasing hospital LOS with increasing CCI, ASCCI, and ASECI scores (OR 57.500, P = 0.001, 95%CI 5.687–581.399; OR 71.500, P = 0.001,
95%CI 5.689–898.642; and OR 19.556, P = 0.001, 95%CI 3.315–115.372, respectively). The result was similar for the outcome of critical illness (OR 21.333, P = 0.001, 95%CI 3.565–127.672; OR 13.000, P = 0.009, 95%CI 1.921–87.990; OR 11.333, P = 0.008, 95%CI
1.859–69.080, respectively). |
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Zhu, X, Xia, et al |
International Journal of Mental Health Promotion |
Public Health response| Interventions de santé publique |
This study investigated the mental status and psychological needs of police officers during the COVID-19 outbreak in
China. The Anti-Pandemic Public Mental Status Scale and self-administered Psychological Needs Scale were administered online to police officers in Y city, a significant sub-central city of Hubei Province, where was affected by the pandemic the most seriously.
Compared with the national public and Y city public data previously measured using the same Scale, this study found that 24.6% of the Y city police suffered maladaptive problems. The mental status of the national public was the best, followed by the Y city
police. The mental status of the Y city public was the worst. Moreover, there was a significant interaction between gender and unit type of Y city police (p = 0.02). The mental status of female police working in prisons was worse than their male counterparts
(p = 0.01). Furthermore, psychological needs survey results showed that the police most wanted to learn the topics of self-adjustment and family relations. The most desired psychological assistances were relaxation and stress reduction, while the percentage
of willingness to choose psychological counseling was low. |
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Ziegler, Z |
Rambam Maimonides Medical Journal |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This short paper discusses another way of looking at the spread of COVID-19, by focusing on the daily rate of infection,
defined as the daily rate of increase in the number of infected persons. It is shown that the daily rate is monotonically decreasing, after a short initial period, in all countries, and that the pattern is similar in all countries. This appears to be a universal
phenomenon. Based on these calculations, the April 1, 2020 data for Western Europe were sufficient to predict the beginning of the end of COVID-19 in that region before the end of that month. |
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Real-time forecasting of the COVID-19 epidemic using the richards model in South
Sulawesi, Indonesia |
Zuhairoh, F, Rosadi, et al |
Indonesian Journal of Science and Technology |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study modeled the growth of COVID-19 cases in South Sulawesi in the top 5 provinces with the largest COVID-19
cases in Indonesia and predicted when this pandemic reaches the peak of spread and when it ends. This paper used the Richards model, which is an extension of a simple logistic growth model with additional scaling parameters. results are that the maximum cumulative
number of COVID-19 cases has reached 10,000 to 12,000 cases. The peak of the pandemic is estimated to occur from June to July 2020 while continuing to impose social restrictions. The condition in South Sulawesi shows a sloping curve around October 2020, which
means that there are still additional cases but not significant. When entering November, the curve starts to flat which indicates the addition of very small cases until the pandemic ends. The results of the pandemic peak prediction are the same as the Indonesian
data; what is different is the prediction of when the pandemic will end. |
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Liver Research |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
The authors investigated if multidisciplinary teams (MDTs) and individualized treatment plans, accurate prediction
of disease progression and timely interventions are vital to effectively reduce mortality in COVID-19 patients. In general, severe/critical cases account for 18–20% of COVID-19 patients with a mortality of up to 61.5%. MDT treated 80% of the severe cases and
19.5% of critical cases with average age of 63.8 years. 68% of the patients had an underlying disease and recovery rate was 84.4%, mortality was 2.6% demonstrating that MDT can reduce mortality rate and improve cure rate in elderly infections. |
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Br J Surg |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
COVIDTrach is a UK multidisciplinary collaborative project that aims to evaluate the outcomes of tracheostomy in COVID-19
patients. It also examines the implementation of national guidance in COVID-19 tracheostomies and the incidence of COVID-19 infections amongst those health care workers involved in the procedure. 564 tracheostomies from 78 UK NHS hospitals data was shared
in this report. An open method of tracheostomy was used in 58% of cases (n = 323/560), a percutaneous method in 39% (n = 217/560) and a hybrid method was used in 3% (n = 20/560). Mortality following tracheostomy in COVID‐19 patients was 12% (n = 62/530) with
two deaths attributed to post‐operative tracheostomy complications and the other 60 (97%) recorded as “COVID‐19 related”. The COVID‐19 test was positive in 86%. |
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Abbo, A, Miller, et al |
Rambam Maimonides Medical Journal |
Review Literature| Revue de littérature |
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Impact of COVID-19 in pediatric dentistry: A literature review |
Achmad, H, Djais, et al |
International Journal of Pharmaceutical Research |
Review Literature| Revue de littérature |
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Acosta, SMJ |
Revista Cubana de Pediatria |
Review Literature| Revue de littérature |
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Agrawal, D, Jaiswal, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Alamer, Ahmad, Almulhim, et al |
Research Square prepub |
Review Literature| Revue de littérature |
MA: an updated search through 7/4/2020 in the PubMed, Cochrane, and medRxiv.org databases. In summary, our meta-analysis
of studies accrued to 7/4/2020 suggests no evidence of an association of ACEI/ARB exposure with mortality, COVID-19 disease severity, or hospitalization.
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Aldahlawi, SA, Afifi, et al |
Open Dentistry Journal |
Review Literature| Revue de littérature |
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32666917; Case Report: COVID-19–Associated Bilateral Spontaneous Pneumothorax—A Literature
Review |
Alhakeem, A, Khan, et al |
American Journal of Tropical Medicine and Hygiene |
Review Literature| Revue de littérature |
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Al-Qahtani, W, Alneghery, et al |
Revista Mexicana de Ingeniera Quimica |
Review Literature| Revue de littérature |
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Alshammari, E |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Covid-19, Chaos theory and the “drop of honey effect”. Viruses and human behavior |
António Filipe, J |
Estudios de Economia Aplicada |
Review Literature| Revue de littérature |
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Asrani, P, Hasan, et al |
Omics |
Review Literature| Revue de littérature |
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Azizi, MH, Azizi, et al |
Archives of Iranian medicine |
Review Literature| Revue de littérature |
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Health psychology and coronavirus pandemic crisis (COVID-19): A review study |
Bagherian-Sararoudi, R, Alipour, et al |
Journal of Isfahan Medical School |
Review Literature| Revue de littérature |
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Review Paper: Paying attention to circadian rhythms in the treatment of COVID-19 |
Bakhtazad, A, Jafari, et al |
Basic and Clinical Neuroscience |
Review Literature| Revue de littérature |
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Bansal, M, Walia, et al |
International Journal of Applied Pharmaceutics |
Review Literature| Revue de littérature |
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Beheshtkhoo, N, Alipour, et al |
Journal of Environmental Treatment Techniques |
Review Literature| Revue de littérature |
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Bhattacharya, S, Sinha, et al |
Journal of Communicable Diseases |
Review Literature| Revue de littérature |
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Biesalski, HK |
Curr Opin Clin Nutr Metab Care |
Review Literature| Revue de littérature |
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Bonvecchio, A, Bernal, et al |
Archivos Latinoamericanos de Nutricion |
Review Literature| Revue de littérature |
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Borage, S, Shelotkar, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Borges do Nascimento, IJ, von Groote, et al |
PLoS One |
Review Literature| Revue de littérature |
SR-MA: searched MEDLINE, CENTRAL, EMBASE, Scopus and LILACS for studies published between January 1, 2019 and March
22, 2020. Severe disease was strongly associated with fever, cough, dyspnea, pneumonia, any computed tomography findings, any ground glass opacity, lymphocytopenia, elevated C-reactive protein, elevated alanine aminotransferase, elevated aspartate aminotransferase,
older age and male sex. |
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Borkar, PS |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
SR:
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COVID-19 and kidney; a mini-review on current concepts and new data |
Boroujeni, EK, Kellner, et al |
Journal of Nephropharmacology |
Review Literature| Revue de littérature |
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Brunelli, S, Falivena, et al |
Mecosan |
Review Literature| Revue de littérature |
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Suggestions for Non-Aerosol or Reduced-Aerosol Restorative Dentistry (for as Long
as is Necessary) |
Burke, FJT, MacKenzie, et al |
Dental update |
Review Literature| Revue de littérature |
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Safety application of novel coronavirus pneumonia antiviral drugs |
Cai, H |
Adverse Drug Reactions Journal |
Review Literature| Revue de littérature |
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Castro-Beltrán, JM, Reyes-Meneses, et al |
Revista Colombiana de Gastroenterologia |
Review Literature| Revue de littérature |
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Pandemic disease and infectious disease in ayurveda with special reference to
covid-19 |
Chandankhede, KJ, Chandankhede, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Coping by the healthcare workers during COVID-19 pandemic in developing countries
- A review |
Chandra, A, Vanjare, et al |
Anaesthesia, Pain and Intensive Care |
Review Literature| Revue de littérature |
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Potential Impact of COVID-19-Related Racial Discrimination on the Health of Asian
Americans |
Chen, JA, Zhang, et al |
Am J Public Health |
Review Literature| Revue de littérature |
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Chi, H, Chiu, et al |
Life |
Review Literature| Revue de littérature |
SR-MA: Electronic medical databases were searched from inception to 8 May 2020, including PubMed/Medline, EMBASE, Cumulative
Index to Nursing and Allied Health Literature, National Digital Library of Theses and Dissertations in Taiwan database, Art Image Indexing Service on the Internet Database (Chinese database), and the Cochrane database. In conclusion, approximately half of
COVID-19 patients had OGA, and one-seventh of them had OGA as their initial symptoms. OGA were cardinal symptoms of COVID-19, which may serve as clues for early diagnosis. Diagnostic testing for SARS-CoV-2 was suggested in patients with OGA during the COVID-19
pandemic to ensure timely diagnosis and appropriate quarantine. |
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Christophers, B, Marin, et al |
Pediatr Res |
Review Literature| Revue de littérature |
SR: Six databases (MEDLINE, Scopus, Web of Science, CINAHL, Google Scholar, medRxiv) were searched for studies indexed
from January 1 to May 15, 2020. Data from this independent participant data systematic review revealed that the majority of children with COVID-19 presented with either no symptoms or a single, non-respiratory symptom. |
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Rapid diagnostic tests: Pros, cons and potential use in
the covid-19 management in Tunisia |
Chtioui, MJ, Grati, et al |
Tunisie Medicale |
Review Literature| Revue de littérature |
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Çolakoglu, MK, Öter, et al |
Turkish Journal of Surgery |
Review Literature| Revue de littérature |
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Conroy, KM, Krishnan, et al |
Working with Older People |
Review Literature| Revue de littérature |
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Damani, A, Ghoshal, et al |
Indian Journal of Palliative Care |
Review Literature| Revue de littérature |
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Personal protective equipment (PPE) during
the COVID-19 pandemic-AUBMC experience |
Daye, N, Wahab, et al |
Middle East journal of anesthesiology |
Review Literature| Revue de littérature |
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Use of face masks: Indications for use and handling during the covid-19 pandemic |
de Sousa Neto, AR, de Freitas, et al |
Cogitare Enfermagem |
Review Literature| Revue de littérature |
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Preventive measures for COVID 19 through dincharya and rutucharya mentioned in
ayurvedic text |
Deshpande, MA, Deshpande, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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32897023; Influence of
COVID-19 on male fertility. What is already known? |
Efremov, EA, Kasatonova, et al |
Urologiia (Moscow, Russia : 1999) |
Review Literature| Revue de littérature |
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Management of Idiopathic Intracranial Hypertension during the COVID19 Pandemic |
Elnahry, AG, Elnahry, et al |
Rev Recent Clin Trials |
Review Literature| Revue de littérature |
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Elnour, A, Don, et al |
Journal of Pharmacy and Bioallied Sciences |
Review Literature| Revue de littérature |
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Elrashdy, F, Redwan, et al |
Biomolecules |
Review Literature| Revue de littérature |
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New coronavirus disease (COVID-19): A perspective from Turkey |
Ergonenc, T, Hacibekiroglu, et al |
Anaesthesia, Pain and Intensive Care |
Review Literature| Revue de littérature |
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Erol, V, Sümer, et al |
Turkish Journal of Surgery |
Review Literature| Revue de littérature |
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Esakandari, H, Nabi-Afjadi, et al |
Biological Procedures Online |
Review Literature| Revue de littérature |
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Global supply chains after COVID-19: the end of the road for neoliberal globalisation? |
Free, C, Hecimovic, et al |
Accounting, Auditing and Accountability Journal |
Review Literature| Revue de littérature |
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Ftiha, F, Shalom, et al |
Neurology International |
Review Literature| Revue de littérature |
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Risks of the stay at home policy during the COVID-19 pandemic |
Gäbel, G, Kröger, et al |
Gefasschirurgie |
Review Literature| Revue de littérature |
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Dental facilities during the new corona outbreak: A swot analysis |
Gaffar, B, Alhumaid, et al |
Risk Management and Healthcare Policy |
Review Literature| Revue de littérature |
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Gaisenok, OV |
Voprosy virusologii |
Review Literature| Revue de littérature |
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Galmés, S, Serra, et al |
Nutrients |
Review Literature| Revue de littérature |
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Environmental aspects of the coronaviruses transmission: A narrative review |
Gholipour, S, Shamsizadeh, et al |
Journal of Isfahan Medical School |
Review Literature| Revue de littérature |
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Review of analytical performance of COVID-19 detection methods |
Giri, B, Pandey, et al |
Anal Bioanal Chem |
Review Literature| Revue de littérature |
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Laparoscopy during the COVID-19 pandemic: Absence of evidence is not evidence of
absence |
Goel, P, Basu, et al |
Journal of Indian Association of Pediatric Surgeons |
Review Literature| Revue de littérature |
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Pediatric epilepsy and telemedicine: An alternative in times
of covid-19 |
Gómez, NG, García, et al |
Revista Cubana de Pediatria |
Review Literature| Revue de littérature |
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Making virtue of necessity. Experiences and lessons from Spain during Covid-19 |
Gómez-Ciriano, EJ |
Social Work Education |
Review Literature| Revue de littérature |
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Guaschino, E, Tassorelli, et al |
Confinia Cephalalgica |
Review Literature| Revue de littérature |
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Gullot, CC, Serpa, et al |
Revista Cubana de Pediatria |
Review Literature| Revue de littérature |
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Hale, JM |
Heredity (Edinb) |
Review Literature| Revue de littérature |
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Hamid, MH, Afzal, et al |
Pakistan Paediatric Journal |
Review Literature| Revue de littérature |
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Covid-19: Insight into the asymptomatic sars-cov-2 infection and transmission |
Han, D, Li, et al |
International Journal of Biological Sciences |
Review Literature| Revue de littérature |
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An overview of precautions for researchers in COVID-19
pandemic |
Harikrishnan, P |
Trends in Biomaterials and Artificial Organs |
Review Literature| Revue de littérature |
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Harikrishnan, P, Krishnan, et al |
Trends in Biomaterials and Artificial Organs |
Review Literature| Revue de littérature |
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Harnett, J, Oakes, et al |
Advances in Integrative Medicine |
Review Literature| Revue de littérature |
Rapid Review: Relevant studies were identified by searching MEDLINE (Ovid), EMBASE (Ovid), AMED (Ovid) and CINAHL (EBSCO)
for articles published from inception to May 2020. Overall, the evidence obtained from the five studies included in this review involving 936 people suggests that mono-herbal preparations of S.nigra berry when taken close to the onset of symptoms and for up
to two weeks, may assist in relieving the symptoms of the common cold and influenza. |
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Havermans, T, Duff, et al |
Curr Opin Pulm Med |
Review Literature| Revue de littérature |
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Helmi, M, Sari, et al |
Systematic Reviews in Pharmacy |
Review Literature| Revue de littérature |
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Are Adequate Vitamin D Levels Helpful in Fighting COVID-19? A Look at the Evidence |
Hoong, CWS, Huilin, et al |
Horm Metab Res |
Review Literature| Revue de littérature |
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An overview of coronavirus and progress in its detection and treatment |
Hu, X, Ren, et al |
Chinese Journal of Microbiology and Immunology (China) |
Review Literature| Revue de littérature |
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Huang, AT, Garcia-Carreras, et al |
Nat Commun |
Review Literature| Revue de littérature |
SR |
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Covid-19: Universal screening is likely to miss infected people, review finds |
Iacobucci, G |
Bmj |
Review Literature| Revue de littérature |
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Corona virus-herbal approach for boosting immunity and influencing viral activity |
Iqbal, A, Quraishi, et al |
International Journal of Pharmaceutical Research |
Review Literature| Revue de littérature |
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Iupatov, EY, Maltseva, et al |
Obstetrics, Gynecology and Reproduction |
Review Literature| Revue de littérature |
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Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal? |
Jans, DA, Wagstaff, et al |
Cells |
Review Literature| Revue de littérature |
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COVID-19 and Smoking: A Systematic Review and Meta-Analysis of the Evidence |
Jiménez-Ruiz, CA, López-Padilla, et al |
Archivos de Bronconeumologia |
Review Literature| Revue de littérature |
SR-MA: The literature search was conducted on 17 March 2020, using two databases (PubMed, ScienceDirect). Current and
past smoking produces a more serious clinical form of Covid-19 and more frequently leads to intensive care admission, intubation, and death.
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Juul, S, Nielsen, et al |
PLoS Med |
Review Literature| Revue de littérature |
SR-MA: searched relevant databases and websites for published and unpublished trials until August 7, 2020. Our results
show that dexamethasone and remdesivir might be beneficial for COVID-19 patients, but the certainty of the evidence was low to very low, so more trials are needed.
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Hyperglycemia and possible mechanisms of β-cell damage in patients with covid-19 |
Kalmykova, ZA, Kononenko, et al |
Diabetes Mellitus |
Review Literature| Revue de littérature |
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Overview and preventive strategies of coronavirus among healthcare communities |
Kannuchamy, KS, Kesavelu, et al |
International Journal of Current Research and Review |
Review Literature| Revue de littérature |
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Kashyap, VK, Dhasmana, et al |
International Journal of Molecular Sciences |
Review Literature| Revue de littérature |
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Kaushik, S, Kumar, et al |
PLoS Pathogens |
Review Literature| Revue de littérature |
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New ways to manage
pandemics: Using technologies in the era of COVID-19, a narrative review |
Khaleghi, A, Mohammadi, et al |
Iranian Journal of Psychiatry |
Review Literature| Revue de littérature |
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Male Fertility and the COVID-19 Pandemic: Systematic Review of the Literature |
Khalili, MA, Leisegang, et al |
World J Mens Health |
Review Literature| Revue de littérature |
SR: literature search using PubMed and Google Scholar. The recent literature provides evidence that male gonads may
be potentially vulnerable to SARS-CoV-2 infection, recommending caution to pregnant women and couples planning natural pregnancy or assisted reproduction. |
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Khan, A, Gurmule, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Digestive manifestations in covid-19: Prevalence and prognostic
impact |
Kharrat, HE, Ghanem, et al |
Tunisie Medicale |
Review Literature| Revue de littérature |
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Kilian, A, Chock, et al |
Seminars in arthritis and rheumatism |
Review Literature| Revue de littérature |
ScR: MEDLINE (Ovid), Scopus, Embase (Ovid), Proquest Dissertations and Theses, Cochrane Database of Systematic Reviews,
and OpenGrey were searched on April 1, 2020. This scoping review identified that some medication classes may confer increased risk of acute respiratory viral infections.
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Koma, T, Adachi, et al |
Frontiers in Microbiology |
Review Literature| Revue de littérature |
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32739398; Vertical transmission of coronavirus disease 2019: a systematic review
and meta-analysis |
Kotlyar, AM, Grechukhina, et al |
American Journal of Obstetrics and Gynecology |
Review Literature| Revue de littérature |
SR-MA: studies published until May 28, 2020, were retrieved from PubMed, EMBASE, medRxiv, and bioRxiv collection databases.
Vertical transmission of severe acute respiratory syndrome coronavirus 2 is possible and seems to occur in a minority of cases of maternal coronavirus disease 2019 infection in the third trimester. The rates of infection are similar to those of other pathogens
that cause congenital infections. |
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32891399; Meta-analysis of Effect of Statins in Patients with COVID-19 |
Kow, CS, Hasan, et al |
American Journal of Cardiology |
Review Literature| Revue de littérature |
MA: searched PubMed, Google Scholar, and medRxiv (preprint repository) databases, up to 27 July 2020.
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Tocilizumab in Sars-cov-2 Patients with the Syndrome of Cytokine Storm;
a Narrative review |
Kulanthaivel, S, Kaliberdenko, et al |
Rev Recent Clin Trials |
Review Literature| Revue de littérature |
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Kumar, C, Varghese, et al |
Trends in Biomaterials and Artificial Organs |
Review Literature| Revue de littérature |
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Lasheras, I, Gracia-García, et al |
International Journal of Environmental Research and Public Health |
Review Literature| Revue de littérature |
Rapid Review-MA: searched PubMed on 26 August 2020. While some preventive and risk factors have been previously identified
in a non-pandemic context, knowledge and cognitions on COVID-19 transmission, treatment, prognosis and prevention negatively correlate with anxiety, emerging as a key preventive factor that may provide a rationale for why the levels of anxiety have remained
stable in medical students during the pandemic while increasing in their non-medical peers and the general population.
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Children in Coronaviruses' Wonderland: What clinicians need to know |
Lassandro, G, Palladino, et al |
Mediterranean Journal of Hematology and Infectious Diseases |
Review Literature| Revue de littérature |
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Short- and Potential Long-term Adverse Health Outcomes of COVID-19: A Rapid
Review |
Leung, T, Chan, et al |
Emerg Microbes Infect |
Review Literature| Revue de littérature |
Rapid Review |
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Epidemic Situation, Prevention, Control of Influenza A and Its Enlightenment
for COVID-19 |
Li, Y, Liang, et al |
Research of Environmental Sciences |
Review Literature| Revue de littérature |
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A review of research of conjunctiva transmission and conjunctivitis of
SARS-CoV-2 |
Liu, J, Feng, et al |
International Eye Science |
Review Literature| Revue de littérature |
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32886936; Direct or Collateral Liver Damage in SARS-CoV-2-Infected Patients |
Lizardo-Thiebaud, M, Cervantes-Alvarez, et al |
Seminars in liver disease |
Review Literature| Revue de littérature |
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Maciorowski, D, Idrissi, et al |
SLAS Discov |
Review Literature| Revue de littérature |
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Mackuľak, T, Bírošová, et al |
Chemicke Listy |
Review Literature| Revue de littérature |
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Mahmood, Z, Alrefai, et al |
Vaccines |
Review Literature| Revue de littérature |
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Airway management in the operating room during
the COVID-19 pandemic: The aubmc experience |
Maroun, W, El-Yahchouchi, et al |
Middle East journal of anesthesiology |
Review Literature| Revue de littérature |
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Mathews, L, Immanuel, et al |
Indian Journal of Palliative Care |
Review Literature| Revue de littérature |
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Mavraganis, G, Aivalioti, et al |
Food and Chemical Toxicology |
Review Literature| Revue de littérature |
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McCarney, J |
Johnson Matthey Technology Review |
Review Literature| Revue de littérature |
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Meneguzzo, M, Fiorani, et al |
Mecosan |
Review Literature| Revue de littérature |
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Transmission of SARS-CoV-2: A Review of Viral, Host, and Environmental Factors |
Meyerowitz, EA, Richterman, et al |
Ann Intern Med |
Review Literature| Revue de littérature |
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Review of Mathematical Modeling of the Inflammatory Response in Lung Infections and
Injuries |
Minucci, SB, Heise, et al |
Frontiers in Applied Mathematics and Statistics |
Review Literature| Revue de littérature |
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A review on currently available potential therapeutic options for covid-19 |
Moghadam, SO |
International Journal of General Medicine |
Review Literature| Revue de littérature |
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Momenzadeh, M |
EurAsian Journal of BioSciences |
Review Literature| Revue de littérature |
SR-MA: MEDLINE, PubMed, Cochrane Library, Embase, ISI, google scholar were the electronic databases that used to perform
a systematic literature between 2010 to March 2020. Hypertensions were the most prevalent underlying diseases in COVID-19 patients. |
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Mobile applications for assessing human posture: A systematic literature review |
Moreira, R, Teles, et al |
Electronics (Switzerland) |
Review Literature| Revue de littérature |
SR: 26 articles published between 2010 and 2020 were selected. Results showed that the use of mobile applications
to assist with posture assessment have been demonstrated to be reliable, and this can contribute to clinical practice of health professionals, especially the assessment and reassessment phases of treatments, despite some variations when compared to traditional
methods. |
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Mortaz, E, Tabarsi, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
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Mortazavi, SAR, Ghadimi-Moghadam, et al |
Iranian Journal of Public Health |
Review Literature| Revue de littérature |
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Novel
coronavirus disease 2019 and its impact on pregnancy and neonates |
Muhammad, A, Sufaid, et al |
Pakistan Paediatric Journal |
Review Literature| Revue de littérature |
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The efficacy and safety of antivirus drugs for COVID-19: A systematic review |
Munir, MA, Kuganda, et al |
Systematic Reviews in Pharmacy |
Review Literature| Revue de littérature |
SR: Scopus, Proquest, Sciencedirect / Elsevier database, NCBI, NEJM, Nature, Wiley, Oxford academy were searched for
articles published in the last 3 years. Based on a systematic review it can be concluded that the best drug to cure SARS- CoV-2 or COVID-19 which is the most effective and safe first place is Favipiravir, although there are no data to show that patients treated
with Favipiravir can recover 100%, but Favipiravir treatment has significantly improved time to relieve it.
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Covid-19 – a pandemic & a policy driver to healthcare system in India |
Narahari, KV, Sowjanya, et al |
International Journal of Current Research and Review |
Review Literature| Revue de littérature |
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COVID 19 - Clinical picture in the elderly population: A qualitative systematic review |
Neumann-Podczaska, A, Al-Saad, et al |
Aging and Disease |
Review Literature| Revue de littérature |
SR: Systematic search was performed for articles published between January 1, 2020, and June 1, 2020, using the primary
databases PubMed and ScienceDirect. A large variety of symptom presentations can be observed, including respiratory, gastrointestinal, cardiovascular and neurological manifestations. Abnormalities in inflammation related laboratory measures are also evident,
and in some cases indicative of multi-organ involvement. |
|
Ocal, S |
Journal of Critical and Intensive Care |
Review Literature| Revue de littérature |
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Oladele, JO, Ajayi, et al |
Heliyon |
Review Literature| Revue de littérature |
SR: literature search was done on PubMed Central, Google Scholar, and Medline and conducted between April and May,
2020 |
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Pai, R, Nayak, et al |
Indian Journal of Palliative Care |
Review Literature| Revue de littérature |
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Probiotics against viruses; COVID-19 is a paper tiger: A Systematic Review |
Paknahad, Z, Moravejolahkami, et al |
Endocr Metab Immune Disord Drug Targets |
Review Literature| Revue de littérature |
SR: searched on PubMed, EMBASE, Google Scholar, Science Direct, Scopus, and Web of Science up to May 2020. Based on
the evidence, some probiotic strains may be useful in SARS-CoV-2 infection; randomized trials are needed to show the facts. |
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Neuroradiological Features of Mild and Severe SARS-CoV-2 Infection |
Pan, S, Chen, et al |
Academic Radiology |
Review Literature| Revue de littérature |
SR: search of the PubMed and Embase databases was performed. Neuroradiological manifestations in COVID-19 infection
are highly heterogeneous and differ based on the severity of COVID-19 infection. Cranial nerve abnormalities appear exclusive to mild infection, with a high degree of olfactory tract involvement, while hemorrhagic events are more common in severe infection.
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Patnaik, KC, Rajput, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Prospect of stem cell therapy to avoid cytokine storm in severe covid-19 |
Pawitan, JA |
International Journal of Applied Pharmaceutics |
Review Literature| Revue de littérature |
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Pham, PV, Vu, et al |
World Journal of Stem Cells |
Review Literature| Revue de littérature |
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Pisey, RS, Vidhate, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Hydroxychloroquine is protective to the heart, not harmful: a systematic review |
Prodromos, CC, Rumschlag, et al |
New Microbes and New Infections |
Review Literature| Revue de littérature |
SR: search of the PubMed, Medline, Cochrane, Embase and Google Scholar databases up to June 1, 2020. No TDP or related
deaths were found to have been reported as a result of HCQ and azithromycin receipt in the peer-reviewed literature. On the contrary, HCQ and azithromycin were both found to substantially reduce cardiac mortality and also decrease thrombosis, arrhythmia and
cholesterol in treated patients in recent peer-reviewed studies and meeting presentations.
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Protti, M, Mandrioli, et al |
Journal of pharmaceutical and biomedical analysis |
Review Literature| Revue de littérature |
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Pushpalatha, C, Varghese, et al |
Trends in Biomaterials and Artificial Organs |
Review Literature| Revue de littérature |
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Preventing COVID-19 Infection in Mental Health Units: Recommendations for Best
Practices |
Quidley-Rodriguez, N, de Tantillo, et al |
Issues Ment Health Nurs |
Review Literature| Revue de littérature |
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Rahman, MT, Sobur, et al |
Microorganisms |
Review Literature| Revue de littérature |
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Hydroxychloroquine and coronavirus disease 2019: A systematic review of a scientific failure |
Rakedzon, S, Khoury, et al |
Rambam Maimonides Medical Journal |
Review Literature| Revue de littérature |
SR: literature search within PubMed for studies published before 20 June 2020. There is no evidence supporting HCQ
for prophylaxis or treatment of COVID-19. Many observational trials were methodologically flawed.
|
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Psychosocial aspects of COVID-19 in the context of palliative care - A quick review |
Rao, S, Spruijt, et al |
Indian Journal of Palliative Care |
Review Literature| Revue de littérature |
|
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Review on role of dhoopan in the prevention of airborne infections (Covid-19) |
Rathi, RB, Rathi, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Current clinical trials protocols and the global effort for immunization against sars-cov-2 |
Rego, GNA, Nucci, et al |
Vaccines |
Review Literature| Revue de littérature |
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Reinert, JP, Reinert, et al |
Journal of intensive care medicine |
Review Literature| Revue de littérature |
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Roccaro, I, Smirni, et al |
Journal of Alzheimer's disease : JAD |
Review Literature| Revue de littérature |
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Human immune response to SARS-CoV-2: What is known? A scoping review |
Rodriguez, IJ, Julián Chamucero, et al |
Infectio |
Review Literature| Revue de littérature |
ScR: earched papers in MEDLINE/PUBMED and EMBASE databases published since December 1st 2019 to to April 9th 2020.
We found that the immune response is characterized by high levels of acute phase reactants, neutrophilia, low levels of NKs and eosinophils, lymphopenia, cytokine storm syndrome, exhausted T cells, impaired cytotoxic response, inadequate helper response and
production of specific antibodies; concluding that immune dysregulation correlates with disease severity and high mortality. |
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The pandemic COVID-19: A tale of viremia, cellular oxidation and immune dysfunction |
Rowaiye, AB, Onuh, et al |
Pan African Medical Journal |
Review Literature| Revue de littérature |
|
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Cochrane corner: Effectiveness of quarantine in reducing the spread of COVID-19 |
Ryan, J, Mazingisa, et al |
Pan African Medical Journal |
Review Literature| Revue de littérature |
Rapid Review: searched for studies in PubMed, Ovid MEDLINE, WHO Global Index Medicus, Embase, CINAHL and various Chinese
databases up to 16 March 2020. the review suggests that quarantine should be part of the COVID-19 combination prevention tool kit for Africa. Therefore, in addition to other public health measures, African countries should roll out COVID-19 testing to identify,
isolate and treat infected people and quarantine their contacts. |
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Multi-system inflammatory syndrome associated
with covid-19 in children |
Sadiq, M, Qureshi, et al |
Pakistan Paediatric Journal |
Review Literature| Revue de littérature |
|
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32781301; Impact of myocardial injury on mortality in patients with COVID-19: a
meta-analysis |
Sanz-Sánchez, J, Vrachatis, et al |
Hellenic Journal of Cardiology |
Review Literature| Revue de littérature |
MA |
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Investigating an emerging virus during a sudden pandemic outbreak |
Sarid, R |
Rambam Maimonides Medical Journal |
Review Literature| Revue de littérature |
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Sarkesh, A, Daei Sorkhabi, et al |
Am J Trop Med Hyg |
Review Literature| Revue de littérature |
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Sawarkar, P, Sawarkar, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Novel coronavirus disease 2019 pharmacological
treatments: A review |
Sawaya, T, Haddad, et al |
Middle East journal of anesthesiology |
Review Literature| Revue de littérature |
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Sayed, ME, Semesmani, et al |
Middle East journal of anesthesiology |
Review Literature| Revue de littérature |
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COVID-19 and diabetes; Possible role of polymorphism and rise of telemedicine |
Sayed, S |
Primary Care Diabetes |
Review Literature| Revue de littérature |
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Schönfeld, N, Otto-Knapp, et al |
Atemwegs- und Lungenkrankheiten |
Review Literature| Revue de littérature |
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Sehrawat, N, Yadav, et al |
Plant Archives |
Review Literature| Revue de littérature |
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Sepahi, MA, Lakkakula, et al |
Journal of Nephropharmacology |
Review Literature| Revue de littérature |
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Shaha, KB, Manandhar, et al |
Postgrad Med J |
Review Literature| Revue de littérature |
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32894563; D-dimer is associated with the risk of mortality in Coronavirus Disease
2019 patients |
Shi, L, Wang, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
MA: PubMed, Chinese National Knowledge Infrastructure (CNKI) and Web of Science were searched until April 26, 2020.
In conclusion, the elevated D-dimer levels were associated with an increased risk of mortality in COVID-19 patients. |
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Role of ifn and complements system: Innate immunity in sars-cov-2 |
Shibabaw, T, Molla, et al |
Journal of Inflammation Research |
Review Literature| Revue de littérature |
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BCG vaccination as protection from COVID-19: Epidemiological and molecular
biological aspects |
Shvarts, YS, Stavitskaya, et al |
Tuberculosis and Lung Diseases |
Review Literature| Revue de littérature |
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Si, S, Teachey, et al |
Therapeutics and Clinical Risk Management |
Review Literature| Revue de littérature |
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Immune response to covid-19: Can we benefit from the sars-cov and mers-cov pandemic
experience? |
Sinderewicz, E, Czelejewska, et al |
Pathogens |
Review Literature| Revue de littérature |
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Singh, AK, Kasle, et al |
Laryngoscope |
Review Literature| Revue de littérature |
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Singh, M, Nagpal, et al |
International Journal of Applied Pharmaceutics |
Review Literature| Revue de littérature |
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Sofiane, F, Lamia, et al |
Curr Drug Deliv |
Review Literature| Revue de littérature |
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The impact of SARS-Cov-2 virus infection on the endocrine system |
Somasundaram, NP, Ranathunga, et al |
Journal of the Endocrine Society |
Review Literature| Revue de littérature |
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Srivastava, KC, Shrivastava, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Steinberg, A, Levy-Lahad, et al |
Rambam Maimonides Medical Journal |
Review Literature| Revue de littérature |
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RAAS inhibitors and statins in covid-19 pandemic -a perspective |
Subramanian, AK, Xavier Christu Rajan, et al |
Journal of Cardiovascular Disease Research |
Review Literature| Revue de littérature |
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A review of coronavirus disease 2019 (COVID-19) for pharmacists |
Sucher, AJ, Sayre, et al |
U.S.Pharmacist |
Review Literature| Revue de littérature |
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Sultana, J, Mazzaglia, et al |
Expert Rev Vaccines |
Review Literature| Revue de littérature |
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Taherian, Z, Motamedi, et al |
Journal of Isfahan Medical School |
Review Literature| Revue de littérature |
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Tekos, F, Skaperda, et al |
Antioxidants |
Review Literature| Revue de littérature |
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Editorial – responsible tourism: A call to action for turbulent times |
Ting, H, Jean, et al |
Asian Journal of Business Research |
Review Literature| Revue de littérature |
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Topal Hançer, A, Yilmaz, et al |
Turkiye Klinikleri Journal of Medical Sciences |
Review Literature| Revue de littérature |
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Torres, EM, García, et al |
Revista Cubana de Pediatria |
Review Literature| Revue de littérature |
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Torres, JA, Cutiño, et al |
Revista Cubana de Pediatria |
Review Literature| Revue de littérature |
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32662416; SARS-COV-2 in ophthalmology: Current evidence and standards for clinical practice |
Torres-Costa, S, Lima-Fontes, et al |
Acta Medica Portuguesa |
Review Literature| Revue de littérature |
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Trevisanuto, D, Cavallin, et al |
Arch Dis Child Fetal Neonatal Ed |
Review Literature| Revue de littérature |
SR: MEDLINE/Pubmed, Scopus, Web of Science, MedRxiv, the Cochrane Database of Systematic Review and the WHO COVID-19
database were searched between 1 December 2019 and 12 May 2020. Most neonates with SARS-CoV-2 infection were asymptomatic or presented mild symptoms, generally were left in spontaneous breathing and had a good prognosis after median 10 days of hospitalisation. |
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Relation between COVID-19 and Guillain-Barré syndrome in adults. Systematic review |
Trujillo Gittermann, LM, Valenzuela Feris, et al |
Neurologia |
Review Literature| Revue de littérature |
SR: PubMed, Cochrane, Science Direct, Medline, and WHO COVID-19 database. We found a strong association between both
conditions; furthermore, the studies analysed highlight differences in the presentation of the disease, with greater severity of symptoms in Guillain-Barre syndrome associated with COVID-19. |
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Turk, C, Turk, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
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Therapeutic effects of lactoferrin in ocular diseases: From dry eye disease to infections |
Vagge, A, Senni, et al |
International Journal of Molecular Sciences |
Review Literature| Revue de littérature |
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Vaidya, HD, Sawarkar, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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32894567; Lopinavir/ritonavir for the treatment of SARS, MERS and COVID-19: a
systematic review |
Vargas, M, Servillo, et al |
European review for medical and pharmacological sciences |
Review Literature| Revue de littérature |
SR: systematically searched the PubMed database from inception to April 30th, 2020. The existing literature does not
suffice for assessing whether Lopinavir/ritonavir has any benefit in SARS, MERS or COVID-19. |
|
Vari, SG |
Ukrainian Biochemical Journal |
Review Literature| Revue de littérature |
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Vikulova, OK, Zuraeva, et al |
Diabetes Mellitus |
Review Literature| Revue de littérature |
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Villeneuve, PJ, Goldberg, et al |
Environmental health perspectives |
Review Literature| Revue de littérature |
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Ayush ministry’s health advisory in covid-19-a critical review |
Wajpeyi, SM |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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The impact of epidemic infectious diseases on the wellbeing of migrant workers: A systematic
review |
Wang, F, Tian, et al |
International Journal of Wellbeing |
Review Literature| Revue de littérature |
SR: Cochrane Library, WHO Global Research COVID-19 database, APA PsycInfo, CINAHL Plus, ERIC, MEDLINE, Social Index,
PubMed, ProQuest, Social Care Online and EPPI-Mapper were searched. Overall, the studies consistently show that major epidemic outbreaks negatively affect the physical, financial, psychological and social wellbeing of migrant workers.
|
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Wang, Y, Liang, et al |
Research of Environmental Sciences |
Review Literature| Revue de littérature |
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Repurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral Reproduction |
Westmark, CJ, Kiso, et al |
Frontiers in Cell and Developmental Biology |
Review Literature| Revue de littérature |
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Wolkewitz, M, Lambert, et al |
Clinical Epidemiology |
Review Literature| Revue de littérature |
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A review of smell and taste dysfunction in COVID-19 patients |
Wong, DKC, Gendeh, et al |
Medical Journal of Malaysia |
Review Literature| Revue de littérature |
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Multi-organ dysfunction in patients with COVID-19: A systematic review and meta-analysis |
Wu, T, Zuo, et al |
Aging and Disease |
Review Literature| Revue de littérature |
SR-MA: Several online databases were searched for articles published until May 13, 2020. Patients with a history of
organ dysfunction are more susceptible to severe conditions. COVID-19 can aggravate an acute multiorgan injury.
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Xiao, B, Zhou, et al |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University |
Review Literature| Revue de littérature |
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Xue, L, Zhu, et al |
Research of Environmental Sciences |
Review Literature| Revue de littérature |
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Survival Time and Influential Factors of Viruses on Surface of Inanimate
Objects |
Yang, S, Wu, et al |
Research of Environmental Sciences |
Review Literature| Revue de littérature |
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COVID-19: Hemostatic parameters and specifics of antithrombotic treatment |
Yavelov, IS, Drapkina, et al |
Cardiovascular Therapy and Prevention (Russian Federation) |
Review Literature| Revue de littérature |
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Yoon, S, Li, et al |
Medicina (Kaunas) |
Review Literature| Revue de littérature |
SR: searched for all terms related to pediatric COVID-19 in electronic databases (Embase, Medline, PubMed, and Web
of Science) for articles from January 2020. Chest CT scan findings are untrustworthy in younger children with COVID-19 as compared with clinical findings, or significant differences in findings between asymptomatic to symptomatic children. |
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New COVID-19 coronavirus infection in the practice of a neonatologist and
pediatrician |
Zaplatnikov, AL, Osmanov, et al |
Rossiyskiy Vestnik Perinatologii i Pediatrii |
Review Literature| Revue de littérature |
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Zare-Zardini, H, Soltaninejad, et al |
International Journal of General Medicine |
Review Literature| Revue de littérature |
|
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The Use of Non-Steroidal Anti-inflammatory Drugs for Coronavirus Disease 2019:
Adjunct Therapy |
Zhao, D, Zhang, et al |
Cardiol Rev |
Review Literature| Revue de littérature |
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Types, Hazards and Pollution Status of Chlorinated Disinfection By-Products
in Surface Water |
Zhu, H, Xue, et al |
Research of Environmental Sciences |
Review Literature| Revue de littérature |
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32683947; Do We “Do No Harm” in the Management of Acute Cholecystitis in COVID-19
Patients? |
R, Narvaez F, J, et al |
American Surgeon |
Commentary/Editorial| Commentaire/Éditorial |
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Abdelaziz, AB, Berkane, et al |
Tunisie Medicale |
Commentary/Editorial| Commentaire/Éditorial |
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Abdelmalek, R, Maghraoui, et al |
Tunisie Medicale |
Commentary/Editorial| Commentaire/Éditorial |
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Abdel-Wahab, T, Abdel-Wahab, et al |
International Journal of Pharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Combating covid-19 under bolsonaro’s federalism: A case of intergovernmental incoordination |
Abrucio, FL, Grin, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
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Adanur, S, Al, et al |
Eurasian Journal of Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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Sex Workers Should not Be Forgotten in Africa's COVID-19 Response |
Adebisi, YA, Alaran, et al |
Am J Trop Med Hyg |
Commentary/Editorial| Commentaire/Éditorial |
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Adibi, A, Jamshidbeigi, et al |
Iranian Journal of Psychiatry and Behavioral Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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The covid-19 pandemic and social distancing in nigeria: Ignorance or defiance |
Agusi, ER, Ijoma, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Online supervision in the time of COVID-19 crisis: The croatian perspective |
Ajduković, M |
Ljetopis Socijalnog Rada |
Commentary/Editorial| Commentaire/Éditorial |
|
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Multisystem
inflammatory syndrome related to covid-19 in children |
Albelo, ALN, Pacheco, et al |
Revista Cubana de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
|
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Alberca, RW |
J Asthma |
Commentary/Editorial| Commentaire/Éditorial |
|
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Albert, L, Capel, et al |
Diabetes research and clinical practice |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 and chronic pain: Many questions and few certainties |
Alcántara Montero, A, Pacheco de Vasconcelos, et al |
Semergen |
Commentary/Editorial| Commentaire/Éditorial |
|
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32896880; Migrant health in Saudi Arabia during the COVID-19 pandemic |
Ali, MA, Al-Khani, et al |
Eastern Mediterranean Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Potential of electric stimulation for the management of COVID-19 |
Allawadhi, P, Khurana, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
|
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Pregnant women and COVID-19: Isolation as a physical and psychic impact factor |
Almeida, MO, Portugal, et al |
Revista Brasileira de Saude Materno Infantil |
Commentary/Editorial| Commentaire/Éditorial |
|
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Alqahtani, AY, Rajkhan, et al |
Education Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Alshaketheep, KMKI, Salah, et al |
WSEAS Transactions on Business and Economics |
Commentary/Editorial| Commentaire/Éditorial |
|
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Al-Shamahi, A |
Drugs of the Future |
Commentary/Editorial| Commentaire/Éditorial |
|
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Altintas, ND |
Journal of Critical and Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
|
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Alert on the infection by dengue in pediatric population during
the covid-19 pandemic |
Alvaré, LEA, Alvarez, et al |
Revista Cubana de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
|
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Amankwah-Amoah, J, Khan, et al |
European Management Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Anselmi, L, Lazzini, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19 pandemic-the perspective of the American
university of beirut-medical center |
Aouad, MT |
Middle East journal of anesthesiology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Kawasaki syndrome in the pediatric population during the covid-19
pandemic: Reality or myth |
Aquino-Canchari, C, Villanueva-Zúñiga, et al |
Revista Cubana de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
|
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Using the curriculum vitae to promote gender equity during the COVID-19 pandemic |
Arora, VM, Wray, et al |
Proc Natl Acad Sci U S A |
Commentary/Editorial| Commentaire/Éditorial |
|
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Leveraging
standardised data in response to the novel coronavirus outbreak |
Arts, D, McGill, et al |
Medical Writing |
Commentary/Editorial| Commentaire/Éditorial |
|
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Diagnostic for COVID-19: Application for developing countries |
Aryati, A, Maulidan, et al |
International Journal of Pharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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32881062; Hypothesis: The potential therapeutic role of nicorandil in COVID-19 |
Ashour, H, Elsayed, et al |
Clinical and Experimental Pharmacology and Physiology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Being on country as protest: Designing a virtual geography
fieldtrip guided by jindaola |
Atchison, J, Kennedy, et al |
Journal of University Teaching and Learning Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19
and melancholia; Different perception of the concept of stigma and loss |
Badrfam, R, Zandifar, et al |
Iranian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Bangash, MF |
Anaesthesia, Pain and Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
|
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Urological Surgeries During Exit from National Lockdown During COVID-19 Pandemic |
Bansal, D, Chaturvedi, et al |
Indian Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
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Bansal, P, Ahuja, et al |
Anaesthesia, Pain and Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
|
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Barbieri, M, Galletti, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
|
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The COVID-19 infodemic – an accelerated version of the new digital ecosystem |
Bârgãoanu, A, Durach, et al |
Romanian Journal of Communication and Public Relations |
Commentary/Editorial| Commentaire/Éditorial |
|
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Barkay, O, Binay, et al |
Klimik Dergisi |
Commentary/Editorial| Commentaire/Éditorial |
|
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Barnard-Naudé, J |
Philosophy and Rhetoric |
Commentary/Editorial| Commentaire/Éditorial |
|
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Barresi, G, Catalfo, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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Single-Use (Disposable) Flexible Bronchoscopes: The Future of Bronchoscopy? |
Barron, SP, Kennedy, et al |
Adv Ther |
Commentary/Editorial| Commentaire/Éditorial |
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Barzilai, N, Appleby, et al |
Aging and Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Bawari, H, Chaple, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Beyond Infection: Integrating Competence into Reservoir Host Prediction |
Becker, DJ, Seifert, et al |
Trends in Ecology and Evolution |
Commentary/Editorial| Commentaire/Éditorial |
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Behera, D |
Indian Journal of Tuberculosis |
Commentary/Editorial| Commentaire/Éditorial |
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Not the time for central bank digital currency. Why cash is still irreplaceable |
Belke, A, Beretta, et al |
Credit and Capital Markets |
Commentary/Editorial| Commentaire/Éditorial |
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Benabou, R, Abubakar, et al |
Pharmacy times |
Commentary/Editorial| Commentaire/Éditorial |
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Benson-Pope, S, Gearry, et al |
Alimentary Pharmacology & Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
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Benvenuto, M, Rosa, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 pandemic in italy: Policy and technology impact on health and non-health
outcomes |
Berardi, C, Antonini, et al |
Health Policy and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Bernard-Donals, M |
Philosophy and Rhetoric |
Commentary/Editorial| Commentaire/Éditorial |
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Investigation of the hypothesis of biofilm formation in coronavirus (COVID-19) |
Besharati, S, Farnia, et al |
Biomedical and Biotechnology Research Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Bessa, K, Luz, et al |
Atelie Geografico |
Commentary/Editorial| Commentaire/Éditorial |
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Bevacqua, RJ, Perrone, et al |
Insuficiencia Cardiaca |
Commentary/Editorial| Commentaire/Éditorial |
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Bhatia, A, Fabbri, et al |
Bulletin of the World Health Organization |
Commentary/Editorial| Commentaire/Éditorial |
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Quarantine and isolation are the two integral pillars to dodge COVID-19 outbreak |
Bhattacharya, S, Kosey, et al |
Open Dentistry Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Bigoni, A, Fink, et al |
Public health |
Commentary/Editorial| Commentaire/Éditorial |
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We need compassionate leadership management based on evidence to defeat COVID-19 |
Binagwaho, A |
International Journal of Health Policy and Management |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Related Respiratory Failure and Lymphopenia Do Not Seem Associated with
Pneumocystosis |
Blaize, M, Mayaux, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Blanco, C, Bueno, et al |
Revista de Nefrologia, Dialisis y Trasplante |
Commentary/Editorial| Commentaire/Éditorial |
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Blank, C |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Top 5 things to know about covid-19: FDA responds to shortages,
plus other important updates |
Blank, C |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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32888757; Contrast Echocardiography in VV-ECMO-Dependent Patients with COVID-19 |
Bleakley, C, Smith, et al |
Journal of the American Society of Echocardiography |
Commentary/Editorial| Commentaire/Éditorial |
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Boccaletti, S, Mindlin, et al |
Chaos, Solitons and Fractals |
Commentary/Editorial| Commentaire/Éditorial |
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Chinese migrants and covid-19: Mobility and exclusion in the time of pandemic |
Bofulin, M |
Dve Domovini |
Commentary/Editorial| Commentaire/Éditorial |
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Why Lombardy is an outlier: An anomaly highlighted by COVID-19 |
Bonati, M |
Medico e Bambino |
Commentary/Editorial| Commentaire/Éditorial |
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Bonten, MJM |
Nederlands tijdschrift voor geneeskunde |
Commentary/Editorial| Commentaire/Éditorial |
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Borgonovi, E |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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Boscolo, PR, Lico, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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L’emergenza Covid-19: Possibili lezioni per gli studiosi di management |
Botti, A |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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Boyko, AN, Sivertseva, et al |
Nevrologiya, Neiropsikhiatriya, Psikhosomatika |
Commentary/Editorial| Commentaire/Éditorial |
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Potential Interventions for SARS-CoV-2 Infections: Zinc Showing Promise |
Brewer, J, Marti, et al |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
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Bric, B, Raile, et al |
International Journal of Mental Health Promotion |
Commentary/Editorial| Commentaire/Éditorial |
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Community paramedicine in British Columbia: A virtual response to covid-19 |
Brittain, M, Michel, et al |
Australasian Journal of Paramedicine |
Commentary/Editorial| Commentaire/Éditorial |
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The HIV and SARS-CoV-2 Parallel in Dentistry from the Perspectives of the Oral Health
Care Team |
Brondani, M, Donnelly, et al |
JDR Clin Trans Res |
Commentary/Editorial| Commentaire/Éditorial |
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Brunault, R |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Bui, DP, See, et al |
MMWR Morb Mortal Wkly Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Bunkers, SS |
Nurs Sci Q |
Commentary/Editorial| Commentaire/Éditorial |
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Bunkers, SS, Hegge, et al |
Nurs Sci Q |
Commentary/Editorial| Commentaire/Éditorial |
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Burgess, S, Gill, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Buzzetti, R |
Medico e Bambino |
Commentary/Editorial| Commentaire/Éditorial |
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Cabezón, E, Arechaga, et al |
Frontiers in Molecular Biosciences |
Commentary/Editorial| Commentaire/Éditorial |
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Built on shaky ground: Reflections on Canada’s Feminist International Assistance
Policy |
Cadesky, J |
International Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Management of intensive care personnel with COVID-19 exposure risk |
Cankar Dal, H |
Journal of Critical and Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
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CIRCLE 2020 - The First Joint Conference of
the Information Retrieval Communities in Europe |
Cantador, I, Melucci, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Cantore, I, Valente, et al |
Transfusion and Apheresis Science |
Commentary/Editorial| Commentaire/Éditorial |
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Carethers, JM, Sengupta, et al |
Cancer Prev Res (Phila) |
Commentary/Editorial| Commentaire/Éditorial |
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Caruso, R, Belloni, et al |
European Journal of Oncology Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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FMSI guidelines for return to physical activity after coronavirus pandemics
lockdown |
Casasco, M, Pigozzi, et al |
Medicina dello Sport |
Commentary/Editorial| Commentaire/Éditorial |
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Terapia de voz en el contexto de la pandemia covid-19; recomendaciones
para la práctica clínica |
Castillo-Allendes, A, Contreras-Ruston, et al |
Journal of Voice |
Commentary/Editorial| Commentaire/Éditorial |
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Terapia Vocal No Contexto Da Pandemia Do Covid-19; Orientações Para A Prática
Clínica |
Castillo-Allendes, A, Contreras-Ruston, et al |
Journal of Voice |
Commentary/Editorial| Commentaire/Éditorial |
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Cauley, CE, Smith, et al |
Ann Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Consumi sanitari privati e Covid-19: Esperienze e prospettive |
Cavazza, M, Del Vecchio, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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Feasibility of virtual education in the framework of global sanitary emergency |
Cedeño, MYM, Bailón, et al |
Journal of Advanced Research in Dynamical and Control Systems |
Commentary/Editorial| Commentaire/Éditorial |
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Dall’ospedale alla co-produzione collettiva: Come attivare la comunità per il contrasto
al Covid-19 |
Cepiku, D, Giordano, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
|
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Obecné zásady
péče o pacienta s covid-19 na pracovišti intenzivní péče |
Černá Pařízková, R, Mach, et al |
Anesteziologie a Intenzivni Medicina |
Commentary/Editorial| Commentaire/Éditorial |
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Psychosocial
impact of COVID-19: Some evidence, many doubts to be clarified |
Chamarro, A |
Aloma |
Commentary/Editorial| Commentaire/Éditorial |
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Chang, JH, Diop, et al |
Clin Transplant |
Commentary/Editorial| Commentaire/Éditorial |
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Changizi, N, Raeisi, et al |
Archives of Iranian medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Charfi, F, Hamouda, et al |
Tunisie Medicale |
Commentary/Editorial| Commentaire/Éditorial |
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Chatterjee, S, Sengupta, et al |
Aging |
Commentary/Editorial| Commentaire/Éditorial |
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Chaudhari, S, Sharma, et al |
Journal of Medical Physics |
Commentary/Editorial| Commentaire/Éditorial |
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Reconstruction of meaning in life: Meaning made during the pandemic of COVID-19 |
Chen, C, Zhang, et al |
International Journal of Mental Health Promotion |
Commentary/Editorial| Commentaire/Éditorial |
|
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Chen, Chaomei |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Chen, J, He, et al |
Cardiovascular Diagnosis and Therapy |
Commentary/Editorial| Commentaire/Éditorial |
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Cheng, L, Zhang, et al |
Research of Environmental Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Managing COVID-19 in a Novel, Rapidly Deployable Community Isolation Quarantine Facility |
Chia, ML, Him Chau, et al |
Ann Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Antisepsis
for intravitreal injections during the COVID-19 pandemic |
Chien, FY, Leng, et al |
Retina Today |
Commentary/Editorial| Commentaire/Éditorial |
|
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Lung diseases
in times of COVID-19. Think of COPD in patients with shortness of breath |
Christ, MM |
Arzneimitteltherapie |
Commentary/Editorial| Commentaire/Éditorial |
|
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Chung, M |
British Columbia Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Are we on brink of a second COVID-19 wave in Italy? Let's look at Google Trends |
Ciaffi, J, Meliconi, et al |
Intern Emerg Med |
Commentary/Editorial| Commentaire/Éditorial |
|
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The demon ratu macaling brings disease and disaster every year in the rainy season |
Cintron, R, Bleeden, et al |
Philosophy and Rhetoric |
Commentary/Editorial| Commentaire/Éditorial |
|
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Clarke, PN |
Nurs Sci Q |
Commentary/Editorial| Commentaire/Éditorial |
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Planning the Full Recovery Phase: An Antifragile Perspective on Surgery after
COVID-19 |
Cobianchi, L, Dal Mas, et al |
Ann Surg |
Commentary/Editorial| Commentaire/Éditorial |
|
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Cochrane, J |
Australian Educational Computing |
Commentary/Editorial| Commentaire/Éditorial |
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Coggon, J, Gostin, et al |
Public Health Ethics |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and schools. Guidelines of the French Pediatric Society |
Cohen, R, Delacourt, et al |
Archives de Pediatrie |
Commentary/Editorial| Commentaire/Éditorial |
|
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Phronesis and the scientific, ideological, fearful appeal of lockdown policy |
Condit, CM |
Philosophy and Rhetoric |
Commentary/Editorial| Commentaire/Éditorial |
|
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Influence and challenge of COVID-19 in forensic identification |
Cong, B, Liu, et al |
Journal of Forensic Science and Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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The impact of peer-review on undergraduate grades when students decide whether
to participate |
Cook, BR, Kamstra, et al |
Journal of Geography in Higher Education |
Commentary/Editorial| Commentaire/Éditorial |
|
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Coolican, M, Borras, et al |
Journal of Education for Teaching |
Commentary/Editorial| Commentaire/Éditorial |
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New normal: two aspects of adipose tissue in COVID-19-treat and threat? |
Copcu, HE |
Expert Opin Biol Ther |
Commentary/Editorial| Commentaire/Éditorial |
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Cordero-Escobar, I, Abad-Hernández, et al |
Revista Mexicana de Anestesiologia |
Commentary/Editorial| Commentaire/Éditorial |
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Cordie, A, El-Kotamy, et al |
Southern African Journal of HIV Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Correa-Díaz, EP, Ortiz-Yépez, et al |
Revista Ecuatoriana de Neurologia |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus disease 2019 (COVID-19): The importance of its potencial neurological
effects |
Cortés, ME |
Revista Ecuatoriana de Neurologia |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 era of misinformation: When your family does not trust you, will your
patients? |
Cox, SR |
Journal of the American Pharmacists Association |
Commentary/Editorial| Commentaire/Éditorial |
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Crawford, J, Percy, et al |
Journal of University Teaching and Learning Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Crinall, S, Rowbottom, et al |
Knowledge Cultures |
Commentary/Editorial| Commentaire/Éditorial |
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Parenting during the Covid-19 pandemic of 2020: academia, labour and care work |
Crook, S |
Women's History Review |
Commentary/Editorial| Commentaire/Éditorial |
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Cui, Z |
Educational Measurement: Issues and Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Curigliano, G, Banerjee, et al |
Annals of Oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Cziboly, A, Bethlenfalvy, et al |
Research in Drama Education |
Commentary/Editorial| Commentaire/Éditorial |
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Czick, M, Shapter, et al |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
Commentary/Editorial| Commentaire/Éditorial |
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The dying process and death of patients with COVID-19: A reflection in the light of
spirituality |
da Silva, MDCQS, Vilela, et al |
Cogitare Enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
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Daghighi, S, Amini, et al |
Infant Observation |
Commentary/Editorial| Commentaire/Éditorial |
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Damani, A, Ghoshal, et al |
Indian Journal of Palliative Care |
Commentary/Editorial| Commentaire/Éditorial |
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Daniel, S, Venkateswaran, et al |
Indian Journal of Palliative Care |
Commentary/Editorial| Commentaire/Éditorial |
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Danta, CC |
ACS Pharmacology and Translational Science |
Commentary/Editorial| Commentaire/Éditorial |
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Danwang, C, Temgoua, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Dara, M, Talebzadeh, et al |
Avicenna Journal of Medical Biotechnology |
Commentary/Editorial| Commentaire/Éditorial |
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Dawoud, D, Chen, et al |
Research in Social and Administrative Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
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Are female–male imbalances in covid-19 mortality rates driven mainly by innate sex differences? |
Dawson, J, Potcovaru, et al |
Journal of Research in Gender Studies |
Commentary/Editorial| Commentaire/Éditorial |
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de Freitas, DAF, Kuwajima, et al |
Revista Ambiente e Agua |
Commentary/Editorial| Commentaire/Éditorial |
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de Lorenzo, A, Esposito, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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de Mansilla, GCB |
Derecho Animal |
Commentary/Editorial| Commentaire/Éditorial |
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De Miranda Candeiro, GT, Neri, et al |
Iranian Endodontic Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Telerehabilitation for patients with breast cancer through the COVID-19 pandemic |
de Rezende, LF, Francisco, et al |
Breast cancer research and treatment |
Commentary/Editorial| Commentaire/Éditorial |
|
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COVID-19: The greatest global critical care challenge of our time |
Dean Gopalan, P |
Southern African Journal of Critical Care |
Commentary/Editorial| Commentaire/Éditorial |
|
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Editorial: Advancing non-placement work-integrated learning
across the degree |
Dean, B, Eady, et al |
Journal of University Teaching and Learning Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
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Agnihotra (Homa)-an ayurveda therapy in the prevention and control of covid-19 |
Deogade, MS |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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Aeronautics and COVID-19: A reciprocal cause-and-effect phenomenon |
Devezas, T |
Journal of Aerospace Technology and Management |
Commentary/Editorial| Commentaire/Éditorial |
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Di Tano, G, De Maria, et al |
Revista espanola de cardiologia |
Commentary/Editorial| Commentaire/Éditorial |
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32894565; Measures to prevent goggles from fogging during the treatment of Coronavirus
Disease 2019 |
Ding, YL, Gu, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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In defense of the city: From lock-down dystopia to open cities |
Domínguez, JME |
Architecture, City and Environment |
Commentary/Editorial| Commentaire/Éditorial |
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dos Santos Martins, TG |
Acta Medica Portuguesa |
Commentary/Editorial| Commentaire/Éditorial |
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Doshi, P |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Doughty, F, Moshkun, et al |
Dental update |
Commentary/Editorial| Commentaire/Éditorial |
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Coordinating the research response to COVID-19: Mali's approach |
Doumbia, S, Sow, et al |
Health Res Policy Syst |
Commentary/Editorial| Commentaire/Éditorial |
|
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Drosdzol-Cop, A, Fuchs, et al |
Ginekologia polska |
Commentary/Editorial| Commentaire/Éditorial |
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32889103; COVID-19 among Turkish citizens returning from abroad |
Dursun, ZB, Ulu-Kilic, et al |
Travel Medicine and Infectious Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Common value: transferring development rights to make room for water |
Dyca, B, Muldoon-Smith, et al |
Environmental Science and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Dynkin, AA, Telegina, et al |
World Economy and International Relations |
Commentary/Editorial| Commentaire/Éditorial |
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Existential hope and humanism in COVID-19 suicide interventions |
Egargo, FJ, Kahambing, et al |
J Public Health (Oxf) |
Commentary/Editorial| Commentaire/Éditorial |
|
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Eissa, N |
Economies |
Commentary/Editorial| Commentaire/Éditorial |
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Ekiz, T, Kara, et al |
Am J Phys Med Rehabil |
Commentary/Editorial| Commentaire/Éditorial |
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Changes in Lung Cancer Treatment as a Result of the Coronavirus Disease 2019 Pandemic |
Elkrief, A, Kazandjian, et al |
JAMA Oncol |
Commentary/Editorial| Commentaire/Éditorial |
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Ellis, C, Jacobs, et al |
Journal of the National Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Ellis, V, Steadman, et al |
European Journal of Teacher Education |
Commentary/Editorial| Commentaire/Éditorial |
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Social workers practices in handling corona virus pandemic with an multisystemic
approach |
Equatora, MA, Hos, et al |
International Journal of Pharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Eraksoy, H |
Klimik Dergisi |
Commentary/Editorial| Commentaire/Éditorial |
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Esparza, J |
Gaceta medica de Caracas |
Commentary/Editorial| Commentaire/Éditorial |
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32070466; Latest updates on COVID-19 from the european centre for disease
prevention and control |
Eurosurveillance editorial, team |
Eurosurveillance |
Commentary/Editorial| Commentaire/Éditorial |
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Evans, G |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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Evans, G |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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Evans, G |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
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Clock starts ticking when
COVID-19 enters nursing home look for any early signs and symptoms |
Evans, G |
Hospital Infection Control and Prevention |
Commentary/Editorial| Commentaire/Éditorial |
|
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Diabetesberatung und berufliche Fortbildung in Zeiten der Covid-19-Pandemie |
Fabisch, G |
Diabetes Aktuell |
Commentary/Editorial| Commentaire/Éditorial |
|
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Fan, J, Lin, et al |
Zhongguo yi xue ke xue yuan xue bao.Acta Academiae Medicinae Sinicae |
Commentary/Editorial| Commentaire/Éditorial |
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Management of chronic cardiometabolic conditions and mental health during COVID-19 |
Farooqi, AT, Snoek, et al |
Primary Care Diabetes |
Commentary/Editorial| Commentaire/Éditorial |
|
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A Call for Action to Safely Deliver Oral Health Care during and Post COVID-19 Pandemic |
Farronato, M, Tadakamadla, et al |
Int J Environ Res Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Feldman, K |
Museum Management and Curatorship |
Commentary/Editorial| Commentaire/Éditorial |
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Some considerations in dermatology teaching about national public health emergencies |
Feng, A, Huang, et al |
Chinese Journal of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Feng, X, Chen, et al |
Anesthesiology |
Commentary/Editorial| Commentaire/Éditorial |
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In the covid-19
storm: It is time to swab! questions to learn and abcd to remember |
Feresin, A, Spedicati, et al |
Medico e Bambino |
Commentary/Editorial| Commentaire/Éditorial |
|
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Fernandes, LL, Borges, et al |
Open Dentistry Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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Post-Zoom: Screen Environments and the Human/Machine Interface |
Ferng, J |
Architectural Theory Review |
Commentary/Editorial| Commentaire/Éditorial |
|
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How to minimize the consequences of quarantine during COVID-19 pandemic? |
Firdos, S, Amanullah, et al |
Middle East Journal of Rehabilitation and Health |
Commentary/Editorial| Commentaire/Éditorial |
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Příjem a třídění pacientů
se suspektním nebo potvrzeným covid-19 |
Flajšingrová, J, Gřegoř, et al |
Anesteziologie a Intenzivni Medicina |
Commentary/Editorial| Commentaire/Éditorial |
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Florczak, KL |
Nurs Sci Q |
Commentary/Editorial| Commentaire/Éditorial |
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When reality breaks from us: lived experience wisdom in the Covid-19 era |
Florence, AC, Miller, et al |
Psychosis |
Commentary/Editorial| Commentaire/Éditorial |
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Airway management protocol for patients with suspected or diagnosed SARS-CoV-2/COVID-19 |
Forero-Vega, J, Carrillo-Torres, et al |
Revista Mexicana de Anestesiologia |
Commentary/Editorial| Commentaire/Éditorial |
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Fortenberry, JD |
Pediatr Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19, gender inequality, and the responsibility of the state |
Fortier, N |
International Journal of Wellbeing |
Commentary/Editorial| Commentaire/Éditorial |
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Management of obstetrics and gynaecological patients with COVID-19 |
Franchi, M, Bosco, et al |
Italian Journal of Gynaecology and Obstetrics |
Commentary/Editorial| Commentaire/Éditorial |
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Francis, V, Gulia, et al |
Indian Journal of Palliative Care |
Commentary/Editorial| Commentaire/Éditorial |
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Recognising
and responding to domestic violence during COVID-19: How telehealth can help |
Freedman, E, Bateson, et al |
Medicine Today |
Commentary/Editorial| Commentaire/Éditorial |
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Freeman, P, Robbins, et al |
J Public Health Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Fu, JB, Wang, et al |
Journal of Forensic Science and Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Funke, M, Tsang, et al |
Econ Model |
Commentary/Editorial| Commentaire/Éditorial |
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Gade, AR, Alavala, et al |
Kidney international |
Commentary/Editorial| Commentaire/Éditorial |
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Gallasch, CH, da Cunha, et al |
Revista Enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
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32546432; In the south, if you give us lemons, we will make you lemonade |
Garcia, B, Christon, et al |
Journal of Cystic Fibrosis |
Commentary/Editorial| Commentaire/Éditorial |
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Garcia, M, Lipskiy, et al |
J Am Med Inform Assoc |
Commentary/Editorial| Commentaire/Éditorial |
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Garcia, PJ, Alarcón, et al |
Am J Trop Med Hyg |
Commentary/Editorial| Commentaire/Éditorial |
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Acute symptomatic crisis and epilepsy in children and adolescents
in times of covid-19 |
García, RJG, Domínguez, et al |
Revista Cubana de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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States slowly ease barriers
to pharmacist-provided covid-19 testing |
Gebhart, F |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Aerosol generating procedures in orthopaedics and recommended protective gear |
Geevarughese, NM, Haq, et al |
Journal of Clinical Orthopaedics and Trauma |
Commentary/Editorial| Commentaire/Éditorial |
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Expert consensus on the diagnosis and treatment of COVID-19 in the
elderly |
Geriatrics Medical Doctor Branch of the Chinese Medical Doctor, Association, National Center of, et al |
Journal of Chinese Physician |
Commentary/Editorial| Commentaire/Éditorial |
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Responses to the pandemic covid-19 in primary health care in oman: Muscat experience |
Ghafri, TA, Ajmi, et al |
Oman Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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The possible role of novel coronavirus 2019 proteins in the development of
drugs and vaccines |
Ghaleh, HEG, Karimi, et al |
Journal of Applied Biotechnology Reports |
Commentary/Editorial| Commentaire/Éditorial |
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Gharat, M |
Australian Prescriber |
Commentary/Editorial| Commentaire/Éditorial |
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Ghiani, E, Galici, et al |
Energies |
Commentary/Editorial| Commentaire/Éditorial |
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Sexual and gender minority health vulnerabilities during the COVID-19 health crisis |
Gibb, JK, DuBois, et al |
American Journal of Human Biology |
Commentary/Editorial| Commentaire/Éditorial |
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Giese, KK |
Journal for Nurse Practitioners |
Commentary/Editorial| Commentaire/Éditorial |
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Treatment of COVID-19 patients in italy: A physician's experience and insights |
Gilad, V, Masoero, et al |
Rambam Maimonides Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Gloster, AT, Zacharia, et al |
Clinical Neuropsychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Gorini, F, Bianchi, et al |
International Journal of Environmental Research and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Goulding, AM, Wu, et al |
American Journal of Infection Control |
Commentary/Editorial| Commentaire/Éditorial |
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Govindarajan, R |
Risk Management and Healthcare Policy |
Commentary/Editorial| Commentaire/Éditorial |
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What effect will the COVID-19 pandemic have on urogynecology services in the United Kingdom? |
Gray, TG, Mukhopadhyay, et al |
Neurourol Urodyn |
Commentary/Editorial| Commentaire/Éditorial |
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Pivoting to Telehealth: the HSS Experience, Value Gained, and Lessons Learned |
Grundstein, MJ, Sandhu, et al |
HSS Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Tocilizumab in COVID-19: finding the optimal route and dose – Authors' reply |
Guaraldi, Giovanni, Milic, et al |
The Lancet Rheumatology |
Commentary/Editorial| Commentaire/Éditorial |
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Guerrini, CJ, Sherkow, et al |
Science |
Commentary/Editorial| Commentaire/Éditorial |
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Guevara-López, U |
Revista Mexicana de Anestesiologia |
Commentary/Editorial| Commentaire/Éditorial |
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Multiple caregiving role with the novel challenge of COVID-19 pandemic: A crisis
situation |
Gulia, A, Mishra, et al |
Indian Journal of Palliative Care |
Commentary/Editorial| Commentaire/Éditorial |
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Gündogan, R |
Pharmaceutisch weekblad |
Commentary/Editorial| Commentaire/Éditorial |
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Gupta, L, Goel, et al |
Journal of the Royal College of Physicians of Edinburgh |
Commentary/Editorial| Commentaire/Éditorial |
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Unraveling the role of palliative surgery in the era of COVID-19 pandemic |
Gupta, R, Karthik, et al |
Indian Journal of Palliative Care |
Commentary/Editorial| Commentaire/Éditorial |
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Blockchain-Envisioned Softwarized Multi-Swarming UAVs to Tackle COVID-I9 Situations |
Gupta, R, Kumari, et al |
IEEE Network |
Commentary/Editorial| Commentaire/Éditorial |
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Gupta, R, Sarma, et al |
Indian Journal of Palliative Care |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations for the care of newborns suspected
or confirmed of infection by sars-cov-2 in Cuba |
Guzmán, AAM, Dieppa, et al |
Revista Cubana de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Coronavirus disease 2019: Latest data on neuroinvasive potential |
Haddadi, K, Asadian, et al |
Iranian Journal of Medical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Hamdy, SM, Abdel-Naseer, et al |
Therapeutics and Clinical Risk Management |
Commentary/Editorial| Commentaire/Éditorial |
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Hang, J, Sun, et al |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University |
Commentary/Editorial| Commentaire/Éditorial |
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Hardy, LJ |
Med Anthropol |
Commentary/Editorial| Commentaire/Éditorial |
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32896878; A systems thinking approach for responding to the COVID-19 pandemic |
Hassan, I, Obaid, et al |
Eastern Mediterranean Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Convalescent plasma as a treatment modality for coronavirus disease 2019 in
Sudan |
Hassan, MO, Osman, et al |
Transfusion and Apheresis Science |
Commentary/Editorial| Commentaire/Éditorial |
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Hassan, SA, Basri, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Hassani, J, Kanazi, et al |
Middle East journal of anesthesiology |
Commentary/Editorial| Commentaire/Éditorial |
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A turning point for telehealth: COVID-19 spurs rapid uptake of connected care |
Hayhurst, C |
Biomedical Instrumentation and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Ambient temperature interferes to COVID-19 ambient temperature |
Hedayati, MA |
Open Microbiology Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Heidari, M, Yoosefee, et al |
Iranian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Hennessey, KC, Shah, et al |
Journal of the American Society of Echocardiography |
Commentary/Editorial| Commentaire/Éditorial |
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Stay
up to date on new COVID-19 data in specific populations |
Hennessy, M, S |
Pharmacy times |
Commentary/Editorial| Commentaire/Éditorial |
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Herrera-Añazco, P, Rabanal, et al |
J Bras Nefrol |
Commentary/Editorial| Commentaire/Éditorial |
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Local newspapers and coronavirus: conceptualising connections, comparisons and cures |
Hess, K, Waller, et al |
Media International Australia |
Commentary/Editorial| Commentaire/Éditorial |
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Nebulized therapy in the covid-19 era: The right tool for the right patient [letter] |
Hess, MW |
International Journal of COPD |
Commentary/Editorial| Commentaire/Éditorial |
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The role of business incubators in creating sustainable small and medium enterprises |
Hewitt, LMM, van Rensburg, et al |
Southern African Journal of Entrepreneurship and Small Business Management |
Commentary/Editorial| Commentaire/Éditorial |
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Higgins, TS, Wu, et al |
JAMA Otolaryngol Head Neck Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Severe autoimmune hemolytic Anemia in COVID-19 İnfection, safely treated with steroids |
Hindilerden, F, Yonal-Hindilerden, et al |
Mediterranean Journal of Hematology and Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and senotherapeutics: Any role for the naturally-occurring dipeptide carnosine? |
Hipkiss, AR |
Aging and Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Non-placement wil: The case of an exercise prescription
clinic |
Hodges, L, Martin, et al |
Journal of University Teaching and Learning Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Erhöhtes sterberisiko:
COVID-19 und diabetes-eine unheilige Allianz |
Hollstein, T |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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32683933; Elective Surgery Recovery Plan in Post-COVID-19 Era |
Hong, YK, Carpenter, et al |
American Surgeon |
Commentary/Editorial| Commentaire/Éditorial |
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PTSD and bipolar II disorder in Fukushima disaster relief workers after the 2011 nuclear
accident |
Hori, A, Takebayashi, et al |
BMJ Case Rep |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: A challenge for forensic and pathological researchers |
Huang, S, Wang, et al |
Journal of Forensic Science and Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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‘Digital Home Schooling’ During the Pandemic: Possibilities and Challenges |
Hung, R, Wati, et al |
Knowledge Cultures |
Commentary/Editorial| Commentaire/Éditorial |
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Analysis of coronavirus covid-19 pandemic model with discrete time delays |
Ibrahim, AA, Maan, et al |
Journal of Advanced Research in Dynamical and Control Systems |
Commentary/Editorial| Commentaire/Éditorial |
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Virtual medical education during the COVID-19 pandemic: how to make it work |
Idris, A, Edris, et al |
Eur Heart J |
Commentary/Editorial| Commentaire/Éditorial |
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Igić, R |
Journal of B.U.ON. |
Commentary/Editorial| Commentaire/Éditorial |
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Ilie, S |
Calitatea Vietii |
Commentary/Editorial| Commentaire/Éditorial |
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Imaging manifestations of lung injury during the COVID-19 outbreak: What have we learned? |
Ilivitzki, A, Rinnot, et al |
Rambam Maimonides Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Inciardi, RM, Lupi, et al |
JAMA Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Jackson, L |
Knowledge Cultures |
Commentary/Editorial| Commentaire/Éditorial |
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Lessons Learnt from COVID-19 Pandemic - A Surgical Resident's Perspective |
Jain, S, Lau, et al |
ANZ J Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Jain, S, Nolan, et al |
Cardiol Rev |
Commentary/Editorial| Commentaire/Éditorial |
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Jain, Siddharth, Jain, et al |
The Lancet Rheumatology |
Commentary/Editorial| Commentaire/Éditorial |
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Jain, T, Jain, et al |
Indian Journal of Palliative Care |
Commentary/Editorial| Commentaire/Éditorial |
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Jaiswal, SR, Malhotra, et al |
Mediterranean Journal of Hematology and Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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A message to you, rudy: Hear reason, or nature will make you feel her |
Jandrić, P |
Knowledge Cultures |
Commentary/Editorial| Commentaire/Éditorial |
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Jemâa, AB, Ismail, et al |
Tunisie Medicale |
Commentary/Editorial| Commentaire/Éditorial |
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Jensen, RD |
Biomedical Instrumentation and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Jesus, I, Vanhee, et al |
J Hum Hypertens |
Commentary/Editorial| Commentaire/Éditorial |
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Jia, X, You, et al |
International Journal of Mental Health Promotion |
Commentary/Editorial| Commentaire/Éditorial |
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Emergency rescue of novel coronavirus pneumonia: Exploration from China |
Jiang, J, Yuan, et al |
Chinese Journal of Evidence-Based Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Therapeutic antibodies and fusion inhibitors targeting the spike protein of
SARS-CoV-2 |
Jiang, S, Zhang, et al |
Expert Opin Ther Targets |
Commentary/Editorial| Commentaire/Éditorial |
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Jiao, N, Chen, et al |
Science Bulletin |
Commentary/Editorial| Commentaire/Éditorial |
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Jilte, AA, Deshpande, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Jin, S, Dai, et al |
Chin Med J (Engl) |
Commentary/Editorial| Commentaire/Éditorial |
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Johnson, NF, V |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Jordà, Ò, Singh, et al |
Finance and Development |
Commentary/Editorial| Commentaire/Éditorial |
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Joseph, AO, Joseph, et al |
International Journal of Health Policy and Management |
Commentary/Editorial| Commentaire/Éditorial |
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Jozsa, C, Ussen, et al |
Journal of the American Society of Echocardiography |
Commentary/Editorial| Commentaire/Éditorial |
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Kaasch, A |
Global Social Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Kaczmarek, M, Shankar, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Kader, HA, Siddik-Sayyid, et al |
Middle East journal of anesthesiology |
Commentary/Editorial| Commentaire/Éditorial |
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Kajdanek, K |
City and Society |
Commentary/Editorial| Commentaire/Éditorial |
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Social Determinants of Health are Needed in COVID-19 Risk Assessments for the
Workforce |
Kalia, N, Conard, et al |
J Occup Environ Med |
Commentary/Editorial| Commentaire/Éditorial |
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Kamalasanan, K |
Trends in Biomaterials and Artificial Organs |
Commentary/Editorial| Commentaire/Éditorial |
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Expedited COVID-19 vaccine trials: A rat-race with challenges and ethical
issues |
Kamble, PH, Dubhashi, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Kamdi, PS, Deogade, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Kamulegeya, LH, Bwanika, et al |
Pan African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Karsten, M, Matte, et al |
Revista Pesquisa em Fisioterapia |
Commentary/Editorial| Commentaire/Éditorial |
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Ke, J, Lan, et al |
Gastroenterology Report |
Commentary/Editorial| Commentaire/Éditorial |
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32896879; Thinking strategically for COVID-19: Suppress and lift, to flatten or to crush? |
Khalife, J |
Eastern Mediterranean Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Khan, HI, Omer, et al |
Pakistan Paediatric Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Making working from home work: reflections on adapting to change |
Khanna, R, Murnane, et al |
Australasian Psychiatry |
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The rationale behind ayurveda codes of conduct (Aachar rasayana) in covid-19
like new disorders |
Khedekar, S, Rathi, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Khodarahmi, R, Sayad, et al |
Journal of the Iranian Chemical Society |
Commentary/Editorial| Commentaire/Éditorial |
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Kidd, W, Murray, et al |
European Journal of Teacher Education |
Commentary/Editorial| Commentaire/Éditorial |
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King, N, Desmarattes, et al |
U.S.Pharmacist |
Commentary/Editorial| Commentaire/Éditorial |
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Klinova, MV |
Voprosy Ekonomiki |
Commentary/Editorial| Commentaire/Éditorial |
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Klöting, N, Ristow, et al |
Obesity (Silver Spring) |
Commentary/Editorial| Commentaire/Éditorial |
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Learning During and From a Crisis: The Student-Led Development of a COVID-19
Curriculum |
Kochis, M, Goessling, et al |
Acad Med |
Commentary/Editorial| Commentaire/Éditorial |
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Kotsimbos, T, Humbert, et al |
Eur Respir J |
Commentary/Editorial| Commentaire/Éditorial |
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32891494; Anticoagulant approach in COVID-19 patients with cerebral
venous thrombosis |
Kow, CS, Zaihan, et al |
Journal of Stroke and Cerebrovascular Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Krishnamurty, J |
Indian Journal of Labour Economics |
Commentary/Editorial| Commentaire/Éditorial |
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Kruse, FM, Jeurissen, et al |
International Journal of Health Policy and Management |
Commentary/Editorial| Commentaire/Éditorial |
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Kumar, A, Kumar, et al |
Acta Paediatrica, International Journal of Paediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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The potential for missed work days due to possible COVID-19 exposure at large scientific
meetings |
Kumar, A, Patel, et al |
Cardiovascular Diagnosis and Therapy |
Commentary/Editorial| Commentaire/Éditorial |
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Decentralising finance using decentralised blockchain oracles |
Kumar, M, Nikhil, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Impact of home confinement during COVID-19 pandemic on Parkinson's disease |
Kumar, N, Gupta, et al |
Parkinsonism and Related Disorders |
Commentary/Editorial| Commentaire/Éditorial |
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Challenges encountered while providing holistic care to a cluster of COVID-19 patients |
Kumar, S, Rathore, et al |
Indian Journal of Palliative Care |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 pandemic prompts changes to pain and palliative care at home |
Kumari, P, Kumar, et al |
Indian Journal of Palliative Care |
Commentary/Editorial| Commentaire/Éditorial |
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Kuo, S, Ou, et al |
Journal of the American Pharmacists Association |
Commentary/Editorial| Commentaire/Éditorial |
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Kusmaul, N |
Journal of the American Medical Directors Association |
Commentary/Editorial| Commentaire/Éditorial |
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NOTTO transplant specific guidelines with reference to COVID-19 |
Kute, V, Guleria, et al |
Indian Journal of Transplantation |
Commentary/Editorial| Commentaire/Éditorial |
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Kyriakoulis, KG, Kokkinidis, et al |
Phlebology |
Commentary/Editorial| Commentaire/Éditorial |
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Leadership under crises: A research agenda for the post-covid-19 era |
Lagowska, U, Sobral, et al |
BAR - Brazilian Administration Review |
Commentary/Editorial| Commentaire/Éditorial |
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Lai, KY, Webster, et al |
Current Opinion in Environmental Sustainability |
Commentary/Editorial| Commentaire/Éditorial |
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Lalchhandama, K |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Lamichhane, JR, Reay-Jones, et al |
Crop Protection |
Commentary/Editorial| Commentaire/Éditorial |
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Langjahr, A |
U.S.Pharmacist |
Commentary/Editorial| Commentaire/Éditorial |
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Lara, PC, Macías-Verde, et al |
Aging and Disease |
Commentary/Editorial| Commentaire/Éditorial |
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32683948; Surgical Critical Care at the Epicenter of the COVID-19 Pandemic |
Latifi, R |
American Surgeon |
Commentary/Editorial| Commentaire/Éditorial |
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Laxmi, R |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Lee, AR, Bailey, et al |
CALL-EJ |
Commentary/Editorial| Commentaire/Éditorial |
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32707256; Male balding is a major risk factor for severe COVID-19 |
Lee, J, Yousaf, et al |
Journal of the American Academy of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 EEG Studies: The Other Coronavirus Spikes We Need to Worry About |
Lee, JW |
Epilepsy Currents |
Commentary/Editorial| Commentaire/Éditorial |
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Lega, F, Petronella, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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Leikach, D |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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32887790; Cell and animal models of SARS-CoV-2 pathogenesis and immunity |
Leist, SR, Schäfer, et al |
Disease models & mechanisms |
Commentary/Editorial| Commentaire/Éditorial |
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Leszczyński, P |
Reumatologia |
Commentary/Editorial| Commentaire/Éditorial |
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Can Glycine Mitigate COVID-19 Associated Tissue Damage and Cytokine Storm? |
Li, CY |
Radiat Res |
Commentary/Editorial| Commentaire/Éditorial |
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Li, G, Tan, et al |
Journal of Chinese Physician |
Commentary/Editorial| Commentaire/Éditorial |
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Influence of Corona Virus Disease 2019 (COVID-19) on Renovation of Rural
Living Environment |
Li, H, Kuai, et al |
Research of Environmental Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Learning from Nature: Chemical Self-Assembly for Materials Science |
Li, W |
Matter |
Commentary/Editorial| Commentaire/Éditorial |
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Frontline health-care workers in combating the covid-19: Respect and reflect |
Li, Y, Luo, et al |
Risk Management and Healthcare Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Li, YH, Wang, et al |
Journal of the Formosan Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Li, ZY, Dang, et al |
Translational Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: Current prediction models for practical use are unsuitable |
Lichert, F |
Pneumologie |
Commentary/Editorial| Commentaire/Éditorial |
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The psychological hotline services quality survey during the pandemic of COVID-19
in Mainland China |
Lin, X, Swift, et al |
International Journal of Mental Health Promotion |
Commentary/Editorial| Commentaire/Éditorial |
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Reflections based on psychology about the effectof COVID-19 pandemic on child
development |
Linhares, MBM, Enumo, et al |
Estudos de Psicologia (Campinas) |
Commentary/Editorial| Commentaire/Éditorial |
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Linn, S, Tzafrir, et al |
Rambam Maimonides Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Lino, DODC, Barreto, et al |
Brazilian Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Sustainable COVID-19 mitigation: Wuhan lockdowns, health inequities, and patient evacuation |
Liu, L |
International Journal of Health Policy and Management |
Commentary/Editorial| Commentaire/Éditorial |
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32868097; Urban-rural disparities in mental health problems related to
COVID-19 in China |
Liu, L, Xue, et al |
General hospital psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Forensic identification of cases with infectious diseases such as novel coronavirus
pneumonia |
Liu, X, Liu, et al |
Journal of Forensic Science and Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Loch, C, Kuan, et al |
Journal of dental education |
Commentary/Editorial| Commentaire/Éditorial |
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Longo, F, Del Vecchio, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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López, SLG, González, et al |
Revista Cubana de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Lou, VWQ |
Asian Journal of Gerontology and Geriatrics |
Commentary/Editorial| Commentaire/Éditorial |
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Early COVID-19 Successes in Skilled Nursing Facilities in San Francisco |
Louie, JK, Stoltey, et al |
Journal of the American Geriatrics Society |
Commentary/Editorial| Commentaire/Éditorial |
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Lovrić, R, Farčić, et al |
Education Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Analysis and Countermeasures of Medical Waste Collection and Management
of COVID-19 in China |
Luo, L, Zhang, et al |
Research of Environmental Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Lyons, VH, Haviland, et al |
Inj Prev |
Commentary/Editorial| Commentaire/Éditorial |
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Ma, L, Zou, et al |
Iranian Journal of Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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Ma, S, Zhang, et al |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University |
Commentary/Editorial| Commentaire/Éditorial |
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Defibrotide in the COVID-19 coagulopathy: what is the timing? |
Macciò, A, Madeddu, et al |
J Thromb Haemost |
Commentary/Editorial| Commentaire/Éditorial |
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Cure ut valeas! multiple uses and faces of masks in pandemic times |
Maia, R, Maia, et al |
Atelie Geografico |
Commentary/Editorial| Commentaire/Éditorial |
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Malek, AE, Gutierrez, et al |
Mediterranean Journal of Hematology and Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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32894970; Diabetes Management during the COVID-19 Pandemic: An Iranian Expert Opinion
Statement |
Malek, M, Hosseinpanah, et al |
Archives of Iranian medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Malekafzali, L |
British Columbia Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Mallis, P, Michalopoulos, et al |
World Journal of Stem Cells |
Commentary/Editorial| Commentaire/Éditorial |
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The Razor's Edge of “Essential” Labor in Food and Agriculture |
Malone, T, Schaefer, et al |
Applied Economic Perspectives and Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Mammen, S, Yousuf, et al |
Journal of opioid management |
Commentary/Editorial| Commentaire/Éditorial |
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Anesthetic management in the pediatric patient with COVID-19 |
Mancera-Elías, G, Arenas-Venegas, et al |
Revista Mexicana de Anestesiologia |
Commentary/Editorial| Commentaire/Éditorial |
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Mancilla, JC, Jaramillo, et al |
Revista Ecuatoriana de Neurologia |
Commentary/Editorial| Commentaire/Éditorial |
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Mann, S |
British Columbia Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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32894562; Will a tumor pandemic come after the COVID-19 pandemic? Head and Neck
cancer perspective |
Mannelli, G, Santoro, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Marasca, AR, Yates, et al |
Estudos de Psicologia (Campinas) |
Commentary/Editorial| Commentaire/Éditorial |
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Marin, JEG, Castellanos, et al |
Infectio |
Commentary/Editorial| Commentaire/Éditorial |
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La gestione delle operations in tempo di crisi: Le prime 10 lezioni apprese dalle
Aziende Sanitarie |
Marsilio, M, Prenestini, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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Martín, FLM |
Revista Cubana de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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Martin, P |
California Agriculture |
Commentary/Editorial| Commentaire/Éditorial |
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Martínez García, E, del Rey de Diego, et al |
Revista espanola de anestesiologia y reanimacion |
Commentary/Editorial| Commentaire/Éditorial |
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32891437; Relevance of neuroimaging in publications on COVID-19 and stroke |
Martínez-Barbero, JP, Tomás-Muñoz, et al |
Neurologia |
Commentary/Editorial| Commentaire/Éditorial |
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Martinez-Ortiz, W, Zhou, et al |
Drug discovery today |
Commentary/Editorial| Commentaire/Éditorial |
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Martins, F |
Hydrocarbon Processing |
Commentary/Editorial| Commentaire/Éditorial |
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Masood, N, Malik, et al |
Frontiers in Cellular and Infection Microbiology |
Commentary/Editorial| Commentaire/Éditorial |
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Rammya Mathew: "Back to school" must be backed by a functioning covid-19 testing programme |
Mathew, R |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Matnazarova, G, Mirtazaev, et al |
International Journal of Pharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Mazzitelli, M, Serapide, et al |
Mediterranean Journal of Hematology and Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 brings a new urgency for advance care planning: Implications of death
education |
McAfee, CA, Jordan, et al |
Death Stud |
Commentary/Editorial| Commentaire/Éditorial |
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Protecting Scientific Integrity and Public Policy Pronouncements
on COVID-19 |
McAleer, M |
Advances in Decision Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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McFee, RB |
Disease-a-Month |
Commentary/Editorial| Commentaire/Éditorial |
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McNaughton, A, Levack, et al |
International Journal of COPD |
Commentary/Editorial| Commentaire/Éditorial |
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Enhanced CPD DO C Getting Back to Work: Lessons from around the World |
McNee, D |
Dental update |
Commentary/Editorial| Commentaire/Éditorial |
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Social Determinants and COVID-19 Disparities: Differential Pandemic Effects and Dynamics |
McNeely, CL, Schintler, et al |
World Medical and Health Policy |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2 Infection: A Role for S1P/S1P Receptor Signaling in the Nervous System? |
Meacci, E, Garcia-Gil, et al |
Int J Mol Sci |
Commentary/Editorial| Commentaire/Éditorial |
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Meddeb, K, Jerbi, et al |
Tunisie Medicale |
Commentary/Editorial| Commentaire/Éditorial |
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Covidfencing effects on cross-border deterritorialism: the case of Europe |
Medeiros, E, Guillermo Ramírez, et al |
European Planning Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Advanced drug delivery systems can assist in targeting coronavirus disease (COVID-19):
A hypothesis |
Mehta, M, Prasher, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Meiksin, J |
MRS Bulletin |
Commentary/Editorial| Commentaire/Éditorial |
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Primary and home care at the end of life in the COVID-19's time |
Mejías Estévez, MJ |
Semergen |
Commentary/Editorial| Commentaire/Éditorial |
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Mendez-Reguera, A, Lopez Cabrera, et al |
Medical Science Educator |
Commentary/Editorial| Commentaire/Éditorial |
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Mendonca, P, Soliman, et al |
Antioxidants |
Commentary/Editorial| Commentaire/Éditorial |
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Menon, AA, Berg, et al |
Am J Respir Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Mercadante, S, Giuliana, et al |
BMJ Support Palliat Care |
Commentary/Editorial| Commentaire/Éditorial |
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Mercurio, AM, Gianakos, et al |
HSS Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Merlin, ARS, Muralidharan, et al |
International Journal of Pharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Meylahn, JA |
HTS Teologiese Studies / Theological Studies |
Commentary/Editorial| Commentaire/Éditorial |
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The impact of sex and gender on the incidence and case fatality of covid-19 infection |
Mihăilă, R, Martin, et al |
Journal of Research in Gender Studies |
Commentary/Editorial| Commentaire/Éditorial |
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Milenkovich, N |
Pharmacy times |
Commentary/Editorial| Commentaire/Éditorial |
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A snapshot of food supply chain in Wuhan under the COVID-19 pandemic |
Min, S, Zhang, et al |
China Agricultural Economic Review |
Commentary/Editorial| Commentaire/Éditorial |
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Mironova, GD, Belosludtseva, et al |
European review for medical and pharmacological sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Mishra, S, Biswas, et al |
Indian Journal of Palliative Care |
Commentary/Editorial| Commentaire/Éditorial |
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Missoni, E, Ussai, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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Moldenhauer, J |
American Pharmaceutical Review |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in Ecuador, how the pandemic strained the surgical healthcare systems
over the edge |
Molina, GA, Rojas, et al |
International Journal of Surgery Open |
Commentary/Editorial| Commentaire/Éditorial |
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Prevention of COVID-19 infection with emphasizing on ablution |
Momeni, G |
Journal of Isfahan Medical School |
Commentary/Editorial| Commentaire/Éditorial |
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The impact of COVID-19 on residents of skilled care facilities throughout the United
States |
Monaco, WA |
International Journal of Current Research and Review |
Commentary/Editorial| Commentaire/Éditorial |
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What comes after the pandemic? A ten-point platform for foundational renewal |
Monnet, J |
Trimestre Economico |
Commentary/Editorial| Commentaire/Éditorial |
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Monteiro, N |
Physis |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7351431; Neonatal nursing in the COVID-19 pandemic: can we improve the future? |
Montes, MT, Herranz-Rubia, et al |
J Neonatal Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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Trends in surgical and beauty masks for a cleaner environment |
Morganti, P, Yudin, et al |
Cosmetics |
Commentary/Editorial| Commentaire/Éditorial |
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Moris, D, Felekouras, et al |
Journal of B.U.ON. |
Commentary/Editorial| Commentaire/Éditorial |
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Moroti, R, Badiu, et al |
Acta Endocrinologica |
Commentary/Editorial| Commentaire/Éditorial |
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The Liability of Poorness: Why the Playing Field is Not Level for Poverty Entrepreneurs |
Morris, MH |
Poverty and Public Policy |
Commentary/Editorial| Commentaire/Éditorial |
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Morrow, BP |
Southern African Journal of Critical Care |
Commentary/Editorial| Commentaire/Éditorial |
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Motamedi, A, Keyhan, et al |
Trauma Monthly |
Commentary/Editorial| Commentaire/Éditorial |
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32868038; Health Behaviors, Wellness, and Multiple Sclerosis Amid COVID-19 |
Motl, R, Ehde, et al |
Archives of Physical Medicine and Rehabilitation |
Commentary/Editorial| Commentaire/Éditorial |
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Mou, J |
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Commentary/Editorial| Commentaire/Éditorial |
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Moura, ECC, Lopez, et al |
Cogitare Enfermagem |
Commentary/Editorial| Commentaire/Éditorial |
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Mousavi, SA, Rad, et al |
Mediterranean Journal of Hematology and Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Social distancing and lockdown due to COVID-19 pandemic will not work in Africa |
Muhammad, F |
Middle East Journal of Rehabilitation and Health |
Commentary/Editorial| Commentaire/Éditorial |
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Policy brief
on child protection during covid-19 crisis in pakistan |
Muhammad, T, Zafar, et al |
Pakistan Paediatric Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of COVID-19 on the UN Sustainable Development Goals (SDGs) |
Mukarram, M |
Strategic Analysis |
Commentary/Editorial| Commentaire/Éditorial |
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Müller, C, Schibli, et al |
Pharmaceuticals |
Commentary/Editorial| Commentaire/Éditorial |
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Müller, O, Lu, et al |
International Journal of Health Policy and Management |
Commentary/Editorial| Commentaire/Éditorial |
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Muniasamy, A, Bhatnagar, et al |
Studies in Computational Intelligence |
Commentary/Editorial| Commentaire/Éditorial |
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Murray, SJ |
Philosophy and Rhetoric |
Commentary/Editorial| Commentaire/Éditorial |
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32592884; Medical student dermatology rotations in the context of COVID-19 |
Muzumdar, S, Grant-Kels, et al |
Journal of the American Academy of Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
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Naiyaz Ahmad, M, Dasgupta, et al |
Drugs of the Future |
Commentary/Editorial| Commentaire/Éditorial |
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Namazi, H, Monajemi, et al |
International Journal of Body, Mind and Culture |
Commentary/Editorial| Commentaire/Éditorial |
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Artificial intelligence (AI) applications for library services and resources in COVID-19
pandemic |
Nawaz, N, Gomes, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Neilson, D |
Knowledge Cultures |
Commentary/Editorial| Commentaire/Éditorial |
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Language in limbo: Being suspended between consolation and control |
Nethersole, R |
Philosophy and Rhetoric |
Commentary/Editorial| Commentaire/Éditorial |
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Ng, BH, Yu-Lin, et al |
Medical Journal of Malaysia |
Commentary/Editorial| Commentaire/Éditorial |
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Nguyen, CT, Saputra, et al |
IEEE Access |
Commentary/Editorial| Commentaire/Éditorial |
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Nguyen, CT, Saputra, et al |
IEEE Access |
Commentary/Editorial| Commentaire/Éditorial |
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Nisio, A, Pellecchia, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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Nj, M, Cf, et al |
JAMA Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7477679; The changes of Coagulation State in Patients Contracted with SARS-COV-19 |
Nosrati, A |
Iran J Pathol |
Commentary/Editorial| Commentaire/Éditorial |
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L’emergenza Covid-19 e l’impatto sul sistema assistenza anziani in Italia |
Notarnicola, E, Berloto, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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Oboh, MA, Omoleke, et al |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Oleribe, OO, Osita-Oleribe, et al |
International Journal of General Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Oliva, A, Caputo, et al |
J Patient Saf |
Commentary/Editorial| Commentaire/Éditorial |
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Oliveira, CRD |
Anaesthesia, Pain and Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
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The role of laboratory testing in hospitalised and critically ill COVID-19-positive
patients |
Omar, S, Baker, et al |
Southern African Journal of Critical Care |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19
and our children: Are we ready for the crisis ahead? |
Omer, R, Khan, et al |
Pakistan Paediatric Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Accepting a “new norm” – what level of PPE do we really need for surgery during COVID-19? |
Ong, CSH, Ong, et al |
British Journal of Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Concrete versus COVID-19:
How the built environment can limit the spread of disease |
Oppel, L |
British Columbia Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Perioperative management of the patient with covid-19 coagulopathy |
Oriol-López, SA |
Revista Mexicana de Anestesiologia |
Commentary/Editorial| Commentaire/Éditorial |
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»Death does not destroy the relationship, but changes it«: The life and theology
of Guy Lafon |
Osredkar, MJ |
Bogoslovni Vestnik |
Commentary/Editorial| Commentaire/Éditorial |
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Nutritional therapy for critically critically ill COVID-19 patients |
Ozer, NT, Gundogan, et al |
Journal of Critical and Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ozyilmaz, E |
Journal of Critical and Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
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Homecare and the COVID-19 pandemic - Experience at an urban specialist cancer palliative
center |
Page, N, Naik, et al |
Indian Journal of Palliative Care |
Commentary/Editorial| Commentaire/Éditorial |
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Palacios, C, Bernal, et al |
Archivos Latinoamericanos de Nutricion |
Commentary/Editorial| Commentaire/Éditorial |
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Pan, XW, Xu, et al |
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association |
Commentary/Editorial| Commentaire/Éditorial |
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Traditional
remedies and COVID-19 : A qualitative exploration of indigenous resources |
Pandey, AK, Gupta, et al |
Plant Archives |
Commentary/Editorial| Commentaire/Éditorial |
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Pandey, K, Vig, et al |
Turkish Journal of Anaesthesiology and Reanimation |
Commentary/Editorial| Commentaire/Éditorial |
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Autopsy procedure and standards for deaths of unknown cause during the COVID-19 pandemic |
Pang, H |
Journal of Forensic Science and Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Panwar, NS, Mishra, et al |
Journal of Public Affairs |
Commentary/Editorial| Commentaire/Éditorial |
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Parlar, ME, Spilka, et al |
Clinical Neuropsychologist |
Commentary/Editorial| Commentaire/Éditorial |
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Patel, M, Raphael, et al |
Pediatr Res |
Commentary/Editorial| Commentaire/Éditorial |
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Patel, MI, Patel, et al |
Journal of Plastic, Reconstructive and Aesthetic Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Patil, D, Naqvi, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Pandemia e comunicazione: L’analisi del caso dell’emergenza Covid-19 |
Pattuglia, S |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
|
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The importance of psychiatric nursing in the covid 19 pandemic process |
Pektekin, Ç |
Journal of psychiatric nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Counselling placements caught up in the mismatch of standards
and realities: Lessons from COVID-19 |
Pelden, S, Banham, et al |
Journal of University Teaching and Learning Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Pellecer-González, LC, Tamariz-Cruz, et al |
Revista Mexicana de Anestesiologia |
Commentary/Editorial| Commentaire/Éditorial |
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Pereira, AK, Oliveira, et al |
Revista de Administracao Publica |
Commentary/Editorial| Commentaire/Éditorial |
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Pereira, MJR, Bernard, et al |
Biota Neotropica |
Commentary/Editorial| Commentaire/Éditorial |
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Perrone, SV, Barbagelata, et al |
Insuficiencia Cardiaca |
Commentary/Editorial| Commentaire/Éditorial |
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Bronchopulmonary MDR protein expression may protect against COVID-19 infection |
Peters, AM, Mohan, et al |
Nucl Med Commun |
Commentary/Editorial| Commentaire/Éditorial |
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Piggott, L, Winchester-Seeto, et al |
Journal of University Teaching and Learning Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Pinsky, BA, Hogan, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Pionke, JJ |
College and Research Libraries News |
Commentary/Editorial| Commentaire/Éditorial |
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Pitlik, SD |
Rambam Maimonides Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Plaat, F |
International Journal of Obstetric Anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Some "Precedents" of Covid-19 amidst geography, history, diffusion, and
containment |
Podda, C, Secchi, et al |
Documenti Geografici |
Commentary/Editorial| Commentaire/Éditorial |
|
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L’arrivo del nuovo Coronavirus nell’era delle malattie croniche
degenerative |
Pongiglione, B |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ponzani, V, Maiello, et al |
AIB Studi |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19, coagulopathy and venous thromboembolism: more questions than answers-comment |
Ponzetto, A, Figura, et al |
Intern Emerg Med |
Commentary/Editorial| Commentaire/Éditorial |
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Porcel, JM |
Eur Respir J |
Commentary/Editorial| Commentaire/Éditorial |
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Porcelloni, L, Mazzanti, et al |
Documenti Geografici |
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Pourdehghan, P, Mostafavi, et al |
Iranian Journal of Psychiatry |
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Pramana, C, Suwantoro, et al |
International Journal of Pharmaceutical Research |
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Pharmacotherapy
considerations in hospitalized patients with COVID-19 pneumonia |
Pruett, W, Morrow, et al |
U.S.Pharmacist |
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Pruthi, M, Chanana, et al |
Indian Journal of Palliative Care |
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Pulimeno, M, Piscitelli, et al |
Health Promotion Perspectives |
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Puranik, A |
Indian Journal of Nuclear Medicine |
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Qian, M, Goodyear, et al |
International Journal of Mental Health Promotion |
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Qodir, Z, Zahra, et al |
Journal of Critical Reviews |
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Quintero-Marzola, I, Galindo-Velásquez, et al |
Revista Colombiana de Gastroenterologia |
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'Sono-cardiopulmonary resuscitation' in COVID-19: a proposed algorithm |
R, LB, Keri, et al |
Postgrad Med J |
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Rábade Castedo, C, Signes-Costa, et al |
Archivos de Bronconeumologia |
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Radhakrishnan, N, Shankar, et al |
Indian Journal of Palliative Care |
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The first COVID-19 incidence in India: A lesson of struggle and survival |
Rajendran, R, Regu, et al |
Journal of Communicable Diseases |
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Rajesh, A, Asaad, et al |
Ann Surg |
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Rali, AS, Howard, et al |
Canadian Journal of Respiratory Therapy |
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Ramazzini, C |
European Journal of Oncology |
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Telemedicine during the COVID-19 pandemic: Experience at Bahrain oncology centre,
Bahrain |
Rana, S, Fadel, et al |
Indian Journal of Palliative Care |
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Management of hemato-oncology children during covid-19 crisis |
Ranjit Kumar, CS, Sukumaran, et al |
International Journal of Research in Pharmaceutical Sciences |
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Pulmonary administration of remdesivir in the treatment of COVID-19 |
Rasmussen, HB, Hansen, et al |
Aaps j |
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Traumatic injuries management in coronavirus disease-2019 (COVID-19) crisis |
Rasouli, HR, Khoshmohabat, et al |
Trauma Monthly |
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Rathore, P, Kumar, et al |
Indian Journal of Palliative Care |
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Chloroquine and hydroxychloroquine: The real saviours of covid 2019? |
Ravi, R, Ponugubati, et al |
International Journal of Pharmaceutical Research |
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32873395; Skin manifestations associated with the new coronavirus SARS-CoV-2
disease |
Redondo-Sendino, Á, González Sánchez, et al |
Medicina clinica |
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Syndrome resembling Kawasaki disease in COVID-19 asymptomatic children |
Rehman, S, Majeed, et al |
Journal of Infection and Public Health |
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How to continue not knowing what is right or wrong even in times of crisis |
Reinertsen, AB |
Knowledge Cultures |
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Respectful maternity care in the context of COVID-19: A human rights perspective |
Reingold, RB, Barbosa, et al |
Int J Gynaecol Obstet |
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32895815; COVID-19-Spätfolge bei Kindern: Multisystemische Entzündung : Coronavirus-Pandemie |
Reinhardt, D |
MMW Fortschritte der Medizin |
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Reyes, JC |
Revista Cubana de Pediatria |
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Reynolds, KL, Klempner, et al |
Oncologist |
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32705979; Constraints lead to opportunities for medical education in times of COVID-19
pandemic |
Ribeiro, JC, Villanueva, et al |
Acta Medica Portuguesa |
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Editorial COVID-19: Turning a huge challenge into an opportunity |
Ritella, G, Sansone, et al |
Qwerty |
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Roa, D, Moyses, et al |
Medical Dosimetry |
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Pathology without microscope: From a projection screen to a virtual slide |
Rodolfo, M, Alessia, et al |
Pathology Research and Practice |
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Disaster preparedness and response in brazil in the face of the COVID-19 pandemic |
Rodrigues, KF, Carpes, et al |
Revista de Administracao Publica |
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Neuroinvasive and neurological damage mechanisms in the infections
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Rodríguez, HRC, Bencomo, et al |
Revista Cubana de Pediatria |
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32827733; Argentine experience with telemedicine for venous care during the COVID-19
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Rodriguez-Santos, F, Loson, et al |
Journal of Vascular Surgery: Venous and Lymphatic Disorders |
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Studying embryonic and fetal development with the virtual microscope! in the
times of COVID-19 |
Rojas R, , M, et al |
International Journal of Morphology |
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32640088; COVID-19 in Italian paediatric patients: The experience of a tertiary children's
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Romani, L, Chiurchiù, et al |
Acta Paediatrica, International Journal of Paediatrics |
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Romanis, EC, Nelson, et al |
Medical Law International |
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Rönnström, N, Roth, et al |
Knowledge Cultures |
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Il modello Value-Based Health Care: Una possibile risposta alla gestione Covid-19 |
Rosa, A, Marolla, et al |
Mecosan |
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Rossouw, B, McCulloch, et al |
Southern African Journal of Critical Care |
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Roux, C, Weyermann, et al |
Forensic science international |
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Rudiansyah, M, Nur’amin, et al |
Systematic Reviews in Pharmacy |
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Rudiansyah, M, Nur'Amin, et al |
Systematic Reviews in Pharmacy |
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Geo-COVID: Movement monitoring based on geo-fence framework for COVID-19 pandemic crisis |
Sahbudin, MAB, Pitchay, et al |
Advances in Mathematics: Scientific Journal |
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Cochlear Implant Rehabilitation During Covid-19 Pandemic: A Parents’ Perspective |
Sahoo, Lokanath, Kumari, et al |
Research Square prepub |
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Sahu, JK, Madaan, et al |
Epilepsy research |
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How the largest slum in india flattened the covid curve? A case study |
Sahu, M, Dobe, et al |
South Eastern European Journal of Public Health |
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Mental health interventions for health professionals in the context of the coronavirus
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Saidel, MGB, Lima, et al |
Revista Enfermagem |
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Wellbeing and stress management during the
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Sakr, CJ, Romani, et al |
Middle East journal of anesthesiology |
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32892991; The Effect of Anticoagulation Use on Mortality in COVID-19 Infection |
Salah, HM, Naser, et al |
American Journal of Cardiology |
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Saleem, A, Sajid, et al |
Journal of pediatric surgery |
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Challenges
to pediatric surgical practices during covid-19 and their solutions |
Saleem, M |
Pakistan Paediatric Journal |
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Salehi, M |
Iranian Journal of Psychiatry |
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Salmanian, M, Salehi, et al |
Iranian Journal of Psychiatry |
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Response to: Factors limiting the utility of bronchoalveolar lavage in the diagnosis
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Salton, F, Geri, et al |
Eur Respir J |
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Rapid response to crisis: Health system lessons from the active period of COVID-19 |
Salvador-Carulla, L, Rosenberg, et al |
Health Policy and Technology |
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Salvamani, S, Tan, et al |
Br J Biomed Sci |
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COVID-19 and Dentistry: Perspectives of an Unfolding Pandemic |
Samaranayake, L |
Dental update |
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Sánchez Santos, R, Garcia Ruiz de Gordejuela, et al |
Cirugia Espanola |
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Emerging Perspectives in Labour Regulation in the Wake of COVID-19 |
Sankaran, K |
Indian Journal of Labour Economics |
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Sano, M, Lapid, et al |
International Psychogeriatrics |
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Santos-Silva, P, Greve, et al |
Revista Brasileira de Medicina do Esporte |
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The Need for Developing Technology-Enabled, Safe, and Ethical Workforce for Healthcare
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Sarbadhikari, SN, Pradhan, et al |
Safety and Health at Work |
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Co-produrre risposte alla pandemia: Il ruolo della user innovation in ambito sanitario |
Savignon, AB, Cepiku, et al |
Mecosan |
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Commentary: Physiological and psychological impact of face mask usage during the covid-19
pandemic |
Scheid, JL, Lupien, et al |
International Journal of Environmental Research and Public Health |
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The ambulatory management of COVID-19 via the German Department of Health |
Schmidt, BC, Sivanathan, et al |
Deutsches Arzteblatt International |
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Schmidt, ME, von Fricken, et al |
World Medical and Health Policy |
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Schultz, RB, DeMers, et al |
Journal of Geography |
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Schuster, C, Weitzman, et al |
Public administration review |
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Schwartz, MD, Emerson, et al |
Aging and Disease |
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32707255; Google searches in patient self-care increase during the COVID-19 lockdown |
Searle, T, Al-Niaimi, et al |
Journal of the American Academy of Dermatology |
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Seghatchian, J, Acker, et al |
Transfusion and Apheresis Science |
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The Risk Of Severe COVID-19 Within Households Of School Employees And School-Age
Children |
Selden, TM, Berdahl, et al |
Health Aff (Millwood) |
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Biting the travel bullet: A motivated reasoning perspective on traveling during
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Sembada, AY, Kalantari, et al |
Annals of Tourism Research |
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Serrão, R, Chaves, et al |
International Journal of Latin American Religions |
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Shachak, A, Alkureishi, et al |
J Am Med Inform Assoc |
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Shamekh, A, Mahmoodpoor, et al |
Health Promotion Perspectives |
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Shamkhalova, MS, Mokrysheva, et al |
Diabetes Mellitus |
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Shanbhag, NM, Phillip, et al |
Pan African Medical Journal |
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Proposed
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Sharma, A, Kumar, et al |
Retina Today |
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Sharma, P |
Indian Journal of Nuclear Medicine |
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Providing palliative home care during COVID-19 pandemic lockdown in India |
Sharma, R |
Indian Journal of Palliative Care |
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Effect of COVID 19 pandemic on service sector in India – An empirical study |
Sharma, S, Chakraborti, et al |
Journal of Critical Reviews |
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Implementation of constitutional rights and freedoms of man and citizen in
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Shchebetun, I, Nikitenko, et al |
Journal of Advanced Research in Dynamical and Control Systems |
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Shekhar, AC, Effiong, et al |
American Journal of Cardiology |
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Shelotkar, P, Borage, et al |
International Journal of Research in Pharmaceutical Sciences |
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Shih, CC, Chen, et al |
Drug and alcohol dependence |
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Shirke, MM, Shaikh, et al |
Trends in Cancer |
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Immunosuppression for COVID-19: Repurposing medicines in a pandemic |
Shivakumar, S, Smibert, et al |
Australian Prescriber |
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Responding to a COVID-19 Outbreak at a Long-Term Care Facility |
Shrader, CD, Assadzandi, et al |
J Appl Gerontol |
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Silva, VL, Dias, et al |
Journal of Microbiology, Immunology and Infection |
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Simpson, A, Farrelly, et al |
Australian Journal of International Affairs |
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Singh, DE |
Journal of Ecumenical Studies |
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Singh, H |
Indian Journal of Nuclear Medicine |
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32682030; Prevalence of cheilitis in health care workers treating patients with
COVID-19 |
Singh, M, Bothra, et al |
Journal of the American Academy of Dermatology |
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Singh, N, Haokip, et al |
Indian Journal of Palliative Care |
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Singh, R, Singh, et al |
Journal of the Anatomical Society of India |
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Anatomy of the COVID-19 Pandemic: An Epidemiologists View Point |
Singh, T, Murugan, et al |
Annals of Neurosciences |
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Singh, T, Pathak, et al |
Journal of Critical Reviews |
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Risk of undetected cases of gestational diabetes mellitus during the COVID-19 pandemic |
Siru, R, Conradie, et al |
Medical Journal of Australia |
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32677846; COVID-19: in the absence of vaccination - 'mask the nation' |
Sleator, RD, Darby, et al |
Future microbiology |
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COVID-19 pandemic and rational use of personal protective equipment |
Soares, SSS, Souza, et al |
Revista Enfermagem |
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Nephrology's history is alive and well and helps predict the future |
Solez, K, Moghe, et al |
Archives of Hellenic Medicine |
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Saliva for use with a point of care assay for the rapid diagnosis of COVID-19 |
SoRelle, JA, Mahimainathan, et al |
Clinica Chimica Acta |
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Sridhar, J, Venincasa, et al |
Retina Today |
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Starcevic, V, Schimmenti, et al |
Clinical Neuropsychiatry |
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Startseva, TV, Kanshina, et al |
Obstetrics, Gynecology and Reproduction |
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Stevanov, M, Brueckner, et al |
European Journal of Vascular and Endovascular Surgery |
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Stower, H |
Nature medicine |
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Letters to the Editors: letter in response to Bhogal and colleagues |
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J Thromb Haemost |
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Management of pediatric rheumatological diseases during the outbreak of COVID-19: Our
experience |
Sutera, D, Mazza, et al |
Mediterranean Journal of Hematology and Infectious Diseases |
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Suwanwongse, K, Shabarek, et al |
Archives de Pediatrie |
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Sweet, D |
British Columbia Medical Journal |
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Sybilski, AJ |
Pediatria i Medycyna Rodzinna |
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Tabatabaei-Malazy, O, Abdollahi, et al |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
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Tabrizi, A, Afshar, et al |
Archives of Iranian medicine |
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Potential Effects of Adjuvant Treatments on Coronavirus Disease 2019 (COVID-19) |
Tagaev, T, Uulu, et al |
Journal of Communicable Diseases |
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How the COVID-19 pandemic experience has affected pediatric palliative care in Mumbai |
Talawadekar, P, Khanna, et al |
Indian Journal of Palliative Care |
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Elective Surgery in the COVID-19 Era: A Screening Algorithm and Related Concerns |
Taliente, F, Mascagni, et al |
Surg Infect (Larchmt) |
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Tamargo, J |
European Cardiology Review |
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Covid-19
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Tamburlini, G, Marchetti, et al |
Medico e Bambino |
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Singapore’s Covid-19 general election: political breakthrough amid a generational
crisis? |
Tan, EKB |
Round Table |
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Location Matters: Geographic Disparities and Impact of Coronavirus Disease 2019 (COVID-19) |
Tan, TQ, Kullar, et al |
J Infect Dis |
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L’emergenza Covid-19 come sfida per il management a livello aziendale e di sistema |
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Mecosan |
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Nosocomial SARS-CoV-2 infections in Japan: A cross-sectional newspaper database survey |
Tani, Y, Sawano, et al |
International Journal of Health Policy and Management |
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Anesthesia in the operating room during the
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Tarraf, S, Zeeni, et al |
Middle East journal of anesthesiology |
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Tarricone, R, Torbica, et al |
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Tateo, L |
Culture and Psychology |
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Tatlow, D, Tatlow, et al |
Clinical and Experimental Pharmacology and Physiology |
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Taxonera, C, Alba, et al |
Alimentary Pharmacology & Therapeutics |
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Teixeira, SC |
Public health |
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Tempero, M |
Journal of the National Comprehensive Cancer Network : JNCCN |
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Temsah, MH, Al-Sohime, et al |
Journal of Infection and Public Health |
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Testarelli, L, Di Nardo, et al |
World Journal of Dentistry |
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Janapadodhwamsa in ayurveda & its comparison with recent covid-19 pandemic |
Thakare, SH, Jumade, et al |
International Journal of Research in Pharmaceutical Sciences |
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Role of Ajan Vruksha/Khandu Chakka plant (Ehretia laevis roxb.) in COVID-19 pandemic |
Thakre, R, Harne, et al |
International Journal of Research in Pharmaceutical Sciences |
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Challenging concerns of transgender community amidst COVID-19 |
Thankachan, A, Rathore, et al |
Indian Journal of Palliative Care |
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Thompson, TJU, Collings, et al |
Forensic science international |
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Tiirinki, H, Tynkkynen, et al |
Health Policy and Technology |
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Pandemic humor: Inventory of the humor scripts produced during
the COVID-19 outbreak |
Torres, JM, Collantes, et al |
Asian EFL Journal |
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Tovar, I, Guerrero, et al |
Cells |
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Il doppio binario delle cure primarie. Alcune scelte di fondo per
i sistemi di tutela della salute |
Tozzi, VD, Ferrara, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
|
|
32868090; Preoperative COVID-19 CT screening in renal transplant recipients |
Tsakok, MT, Chetan, et al |
Clinical radiology |
Commentary/Editorial| Commentaire/Éditorial |
|
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32541250; COVID-19: Epidemiological factors during aerosol-generating medical
procedures |
Tsui, BCH, Deng, et al |
Anesthesia and Analgesia |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Türe, H, Oğuz, et al |
Turkish Journal of Anaesthesiology and Reanimation |
Commentary/Editorial| Commentaire/Éditorial |
|
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Um, SH, Kim, et al |
CiOS Clinics in Orthopedic Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
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Üstün, Ç, Özçiftçi, et al |
Klimik Dergisi |
Commentary/Editorial| Commentaire/Éditorial |
|
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Student-led initiatives’ potential in the covid-19 response in iran |
Vahidi, M, Khave, et al |
International Journal of Health Policy and Management |
Commentary/Editorial| Commentaire/Éditorial |
|
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van Eck, D, Jammaers, et al |
Gender, Work and Organization |
Commentary/Editorial| Commentaire/Éditorial |
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Fighting against COVID-19 in Vietnam: The value of rapid antibody testing should not
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Van Hoang, M |
Health Promotion Perspectives |
Commentary/Editorial| Commentaire/Éditorial |
|
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PMC7411273; SARS-CoV-2 disrupts clinical research: the role of a rare disease-specific
trial network |
van Koningsbruggen-Rietschel, S, Dunlevy, et al |
Eur Respir J |
Commentary/Editorial| Commentaire/Éditorial |
|
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Vargas-Vargas, M, Cortés-Rojo, et al |
Revista Panamericana de Salud Publica/Pan American Journal of Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
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Varma, H |
Trends in Biomaterials and Artificial Organs |
Commentary/Editorial| Commentaire/Éditorial |
|
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MGNREGA in the Times of COVID-19 and Beyond: Can India do More with Less? |
Vasudevan, G, Singh, et al |
Indian Journal of Labour Economics |
Commentary/Editorial| Commentaire/Éditorial |
|
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32527710; Repurposing the PICU for caring critically ill adult patients during
the COVID-19 pandemic |
Vázquez Martínez, JL, Alonso García, et al |
Anales de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
|
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Prime riflessioni sul procurement sanitario durante l’emergenza Covid-19 |
Vecchi, V, Cusumano, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
|
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Venditto, VJ, Hudspeth, et al |
Science |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ripartire dalle cure primarie: Priorità e lezioni imparate alla
luce della Pandemia Covid-19 |
Vendramini, E |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Ventura Wurman, T, Lee, et al |
Counselling Psychology Quarterly |
Commentary/Editorial| Commentaire/Éditorial |
|
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Telehealth: Opportunities in geriatric patient care during COVID-19 |
Vergara, J, Parish, et al |
Geriatric nursing |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Verger, P, Dubé, et al |
Expert Rev Vaccines |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Vo, TS, Vo, et al |
Eurasian Journal of Medicine |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Vohora, D, Jain, et al |
Epilepsia |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wallace, J |
Philosophy and Rhetoric |
Commentary/Editorial| Commentaire/Éditorial |
|
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Walzer, B |
Philosophy and Rhetoric |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Wang, H, Wu, et al |
Chinese Journal of Radiological Medicine and Protection |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Spine surgery: Precautions and strategies to minimize perioperative risks amid COVID-19
outbreak |
Wang, TJV, Ito, et al |
Spine Surgery and Related Research |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wang, Z |
Health Environments Research and Design Journal |
Commentary/Editorial| Commentaire/Éditorial |
|
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European disaster management in response to the COVID-19 pandemic |
Wankmüller, C |
Mind and Society |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wasfy, JH |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Wasmuth, H |
Knowledge Cultures |
Commentary/Editorial| Commentaire/Éditorial |
|
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Wee, LE, Sim, et al |
Journal of Hospital Infection |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Moving safely to phase 2 of the COVID-19 Pandemic: What is more pressing, dates or data? |
Werba, JP, Veglia, et al |
Global Heart |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Strategies for the management of gastrointestinal surgery in the COVID-19 pandemic |
Wexner, SD |
Gastroenterology Report |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wexner, SD, Hoyt, et al |
American Surgeon |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Wexner, SD, Nelson, et al |
American Surgeon |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Wexner, SD, Opelka, et al |
American Surgeon |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
White, BAA, Johnson, et al |
Baylor University Medical Center Proceedings |
Commentary/Editorial| Commentaire/Éditorial |
|
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Caring for underserved patients with heart failure during the COVID-19 pandemic |
White-Williams, C, Clarkson, et al |
Journal of health care for the poor and underserved |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wiemers, EE, Abrahams, et al |
Res Soc Stratif Mobil |
Commentary/Editorial| Commentaire/Éditorial |
|
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Covid-19: Patients are told not to attend A&E for tests as national service falters |
Wilkinson, E |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
|
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“Resist, Rethink, and Restructure”: Teaching About Capitalism, War, and Empire in a Time
of COVID-19 |
Wills, J, Entin, et al |
Radical Teacher |
Commentary/Editorial| Commentaire/Éditorial |
|
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‘'Workplace’ or Workforce: What Are We Preparing Students
For? |
Winchester-Seeto, T, Piggott, et al |
Journal of University Teaching and Learning Practice |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Wuhan Medical Doctor Association of Otorhinolaryngology, Head, Neck, et al |
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
|
|
Wyper, GMA, Assunção, et al |
Archives of Public Health |
Commentary/Editorial| Commentaire/Éditorial |
|
|
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COVID-19: Clinical and laboratory manifestations in novel coronavirus infection |
Xavier, AR, Silva, et al |
Jornal Brasileiro de Patologia e Medicina Laboratorial |
Commentary/Editorial| Commentaire/Éditorial |
|
|
Xue, JZ, Smietana, et al |
Nature Reviews Drug Discovery |
Commentary/Editorial| Commentaire/Éditorial |
|
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Yamada, M, Kimura, et al |
Journal of Nutrition, Health and Aging |
Commentary/Editorial| Commentaire/Éditorial |
|
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|
Yamout, RI, Dakessian-Sailian, et al |
Middle East journal of anesthesiology |
Commentary/Editorial| Commentaire/Éditorial |
|
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Yanai, H |
Journal of Endocrinology and Metabolism |
Commentary/Editorial| Commentaire/Éditorial |
|
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Yancey, NR |
Nurs Sci Q |
Commentary/Editorial| Commentaire/Éditorial |
|
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A double thucydides trap donald trump’s presidency and new bipolarity |
Yefremenko, DV |
Russia in Global Affairs |
Commentary/Editorial| Commentaire/Éditorial |
|
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Yeh, J, Yeh, et al |
Current Women's Health Reviews |
Commentary/Editorial| Commentaire/Éditorial |
|
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Balancing science and art in medicine: Covid-19 and the necessary humanistic
shift in medical care |
Yeh, MJ, Yeh, et al |
Current Women's Health Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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32911861; A wearable stethoscope for long-term ambulatory respiratory health monitoring |
Yilmaz, G, Rapin, et al |
Sensors (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Yu, MS, Kutishenko, et al |
Cardiovascular Therapy and Prevention (Russian Federation) |
Commentary/Editorial| Commentaire/Éditorial |
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Zambrano-Huailla, R |
Revista Colombiana de Gastroenterologia |
Commentary/Editorial| Commentaire/Éditorial |
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Zangrandi, A, Fanelli, et al |
Mecosan |
Commentary/Editorial| Commentaire/Éditorial |
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Zar, HJ, Moore, et al |
South African Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Zarghami, M, Lye, et al |
Iranian Journal of Psychiatry and Behavioral Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Zhang, Y, Yang, et al |
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
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Construction of Medical Waste Emergency Disposal System in China |
Zhang, Z, Cheng, et al |
Research of Environmental Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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Establishment of online platform for psychological assistance during a public health
emergency |
Zhao, C, Shi, et al |
International Journal of Mental Health Promotion |
Commentary/Editorial| Commentaire/Éditorial |
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Zhao, HJ, Yang, et al |
J Cell Mol Med |
Commentary/Editorial| Commentaire/Éditorial |
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Zhao, J, Niu, et al |
Journal of Forensic Science and Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Zhao, X |
Journal of Chinese Political Science |
Commentary/Editorial| Commentaire/Éditorial |
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Cogitation on the mental health service system during the COVID-19 outbreak in
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Zhong, J, Fan, et al |
International Journal of Mental Health Promotion |
Commentary/Editorial| Commentaire/Éditorial |
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patients |
Zhou, Y, Fu, et al |
National Science Review |
Commentary/Editorial| Commentaire/Éditorial |
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Zhu, L |
Human Behavior and Emerging Technologies |
Commentary/Editorial| Commentaire/Éditorial |
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SARS-CoV-2
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Zylka-Menhorn, V, Grunert, et al |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Prescrire international |
Commentary/Editorial| Commentaire/Éditorial |
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Commentary/Editorial| Commentaire/Éditorial |
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Deutsches Arzteblatt International |
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JAMA Cardiology |
Commentary/Editorial| Commentaire/Éditorial |
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Hellenic Journal of Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Dexamethasone is convincing
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Deutsche Apotheker Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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Hellenic Journal of Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Commentary/Editorial| Commentaire/Éditorial |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans e.g.
WHO publication list and activities by collaborators. Members of the Emerging Sciences group develop 1 -2 point summaries of each publication. Please email Lisa Waddell for additional information:
Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability
to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely to influence future results.
Epidemiology:
the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro, attack rates, case number doubling time, case fatality
rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host
to an uninfected host via direct or indirect routes.
Clinical data
of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well as clinical profiles of patients; presenting symptoms, symptoms over
course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and
interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed, number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic
analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics:
Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research:
Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities:
These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response:
This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment preparation/ stock piling supplies; Education
and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature:
All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial:
For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, e.g.
la liste des publications de l'OMS,
et à des activités des collaborateurs. Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction :
La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats. Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro),
les taux d'attaque, le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que les profils
cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance :
La surveillance de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé. Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés,
le nombre de décès, le nombre de personnes guéries. *
Coronavirologie : Toutes les recherches relatives
au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes :
Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes, etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins : Études des candidats à la
vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Modèle animal:
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial :
Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des
commentaires.
journaux
Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives