Good afternoon,
There are 1224 citations in today’s scan. 632 were considered primary research or review literature.
Highlights today include:
CANADA
·
Best et al.,
report on a survey conducted in Canada March 31- April 15 to measure the psychological impact of public health measures. Their results indicate even under the short term, psychological distress (panic, emotional disturbances, depression) is significant.
PUBLIC HEALTH INTERVENTIONS
·
Abedin et al.
apply panel GLM models to COVID-19 infection rates to explore differential effects of time to and extent of widespread testing, in Italy and Australia. The study concludes widespread testing during the early stages of the pandemic favored Australia to
control the outbreak much faster than Italy. The early adoption of widespread testing with lower degree of test positivity rates flattens the curve faster. However, population density has a moderating effect as regions with higher population densities are
likely to experience peeks with a greater number of infections even when test positivity rates are the same.
TRANSMISSION
·
Chun, J. Y., Baek, G., Kim, Y
Studied the transmission onset of COVID-19 relative to the symptom onset, inferring transmission onset time from 72 infector-infectee pairs with defined contact history. The median transmission onset was 1.31 days after, and the peak was 0.72 days before
the symptom onset. The pre-symptomatic transmission proportion was 37%. The transmission onset peaked with the symptom onset and the pre-symptomatic transmission proportion is substantial.
IPAC
·
Lee et al.
characterized the stability of SARS-CoV-2 in three water matrices: fresh, tap, and seawater. The minimum infective dose of SARS-CoV-2 in Vero cells was confirmed to be 10³
PFU/mL. The stability of SARS-CoV-2 varied according to the water matrix: infective SARS-CoV-2 was undetectable after treatment with fresh water and seawater, but remained detectable for 2 days in tap water, when starting
with an initial concentration of 10⁴ PFU/mL. When the starting concentration was increased to 10⁵
PFU/mL, a similar trend was observed. In addition, viral RNA persisted longer than infectious virus in all water matrices. This study was conducted in stagnant water containing a significantly high titer of virus, thus, human-to-human transmission of SARS-CoV-2
through the actual aquatic environment is expected to be rare
IMMUNOLOGY
·
Montenegro et al report seroprevalence of IgG and IgM in two groups in Spain: (1) a random community sample of asymptomatic individuals
in Barcelona and (2) a sample of symptomatic patients followed by general practitioners (GPs). Seroprevalence in the asymptomatic community individuals was 5.47%, whereas in the symptomatic patients followed by GPs seroprevalence was 38.49%, higher in those
reporting fever, aguesia and contact with a patient with SARS-CoV-2 infection.
EPIDEMIOLOGY
·
Stock et al report seroprevalence in asymptomatic front-line health
care workers in New York City. Of the 98 asymptomatic healthcare workers tested, 19 (19.4%) tested positive by RT-qPCR and/or ELISA. An additional 11 (11.2%) individuals were IgG positive without a positive PCR. Two PCR positive individuals subsequently developed
COVID-19 symptoms, while all others remained asymptomatic at 2-week follow-up, demonstrating considerable asymptomatic infection with SARS-CoV-2 within the healthcare workforce, with potential for amplified transmission within health care settings despite
current mitigation policies.
·
Gudipati et al add to the data that suggest that HIV-positive patients
with SARS-CoV-2 infection are not at a greater risk of severe disease or death as compared to HIV-negative patients.
·
Salvador et al
analyse infection and mortality growth curves during the first 30 days of the COVID-19 outbreak in 39 countries. The analysis finds initial epidemic growth rates were significantly accelerated among countries where individuals have an increased tendency
to interact with larger more variable range of individuals (i.e. relational mobility). This relationship between epidemic growth and relational mobility was preserved when controlling for demographics, reporting bias, testing availabilities, cultural dimensions
of individualism, and government efficiency.
·
Zaneti et al
conducted the first quantitative microbial risk assessment that investigates the potential health risks of SARS-CoV-2 in sewage to wastewater treatment plant (WWTP) workers. Results reveal that estimates of viral RNA in sewage at the entrance of WWTPs
ranged from 4.14 × 101 to 5.23 × 103 GC·mL−1. In addition, estimated risks for aggressive and extreme COVID-19 scenarios were likely to be above the derived tolerable infection risk for SARS-CoV-2 of 5.5 × 10−4 pppy, thus reinforcing the concern of sewage
systems as a possible transmission pathway of SARS-CoV-2.
CLINICAL DATA
·
Schmidt et al.
reported four school children with heavy exposure to SARS-CoV-2 with no clinical signs of COVID-19, repeated negative nasopharyngeal swabs for SARS-CoV-2 RNA, and no seroconversion.
·
Arshad et al.
conducted a study on 35 suspected COVID-19 patients, form Pakistan, where conjunctival and oropharyngeal swabs samples were collected. All 35 oropharyngeal swab samples were positive for SARS CoV-2, out of a total of 35 conjunctival swab samples, 3(8.5%)
were detected positive by RT-PCR. Two (66%) out of 3 conjunctival SARS-Cov-2 positive patients had a dry cough, whereas 3(100%) patients were suffering from fever and difficulties in breathing. There was no ocular manifestation observed among patients with
positive conjunctival specimens.
·
Musoke et al
characterizes the patterns of anticoagulation use in COVID-19 patients and the risk of related bleeding. A single center retrospective analysis of 355 adult patients with confirmed diagnosis of COVID-19 was preformed. Results indicate major bleeding
is associated with use of therapeutic anticoagulation in COVID-19, and therapeutic anticoagulation has shown higher mortality and major bleeding trends.
THERAPEUTICS
·
Caruso et al.
We show that methotrexate, an FDA‐approved inhibitor of purine biosynthesis, potently inhibits viral RNA replication, viral protein synthesis, and virus release. The effective antiviral methotrexate concentrations are similar
to those used for established human therapies using the same drug. Methotrexate should be most effective in patients at the earliest appearance of symptoms to effectively prevent viral replication, diffusion of the infection, and possibly fatal complications.
·
Fadaka et al.
sought to provide insights on the anti-COVID-19 mechanism of Dex at both atomic and molecular level against SARS-CoV-2 targets. Computational methods were employed to predict the binding affinity of Dex to SARS-CoV-2 using the Schrodinger suite (v2020-2).
The selected targets were SARS-CoV-2 main protease (Mpro), and host secreted molecules glucocorticoid receptor, and Interleukin-6 (IL-6). Dex showed stronger affinity to its theoretical (glucocorticoid) receptor with a superior docking score of −14.7 and
a good binding energy value of −147.48 kcal/mol; while short hydrogen bond distances were observed in both Mpro and IL-6 when compared to glucocorticoid receptor. This study demonstrates that Dex could bind to both the viral and host receptors as a potential
drug candidate for COVID-19.
·
Abhinand et al.
examine the possible repurposing of existing anti-viral protease inhibitor drugs. The results indicated that, Ritonavir has the highest potency to block SARS-CoV-2 main protease and human TMPRSS2, a host cell factor that aids viral infection. Other drugs
such as Indinavir and Atazanavir also showed favourable binding with Cathepsin B/L that helped viral fusion with the host cell membrane. Further molecular dynamics simulation and MM-PBSA binding free energy calculations confirmed the stability of protein-drug
complexes. These results suggest that protease inhibitors particularly Ritonavir, either alone or in combination with other drugs such as Atazanavir, have the potential to treat COVID-19
·
Yethindra et al.
This exploratory randomized and controlled study on umifenovir recruited 30 hospitalized COVID-19 patients. 15 eligible patients were randomly allocated to each, the treatment and control groups. Time to clinical recovery (TTCR), clinical characteristics,
and tomographic results were analyzed at baseline and five days after treatment to assess the effect of umifenovir. Significant differences in time to clinical recovery were found between the two groups.
ANIMAL MODEL
·
Zhao, et al.,
in an effort to search for the potential intermediate or amplifying animal hosts of SARS-CoV-2, examined receptor activity of ACE2 from 14 mammal species and found that ACE2s from multiple species can support the infectious entry of lentiviral particles
pseudotyped with the wild-type or furin cleavage site-deficient S protein of SARS-CoV-2. ACE2 of human/rhesus monkey and rat/mouse exhibited the highest and lowest receptor activities, respectively.
DIAGNOSTICS
·
Shental et al
developed a method for Pooling-Based Efficient SARS-CoV-2 Testing (P-Best), which identifies all positive subjects within a set of samples using a single round of testing. They pooled sets of 384 samples into 48 pools, providing both an eightfold increase
in testing efficiency and an eightfold reduction in test costs, while identifying up to five positive carriers.
CORONAVIROLOGY
·
Wang et al.
utilize bioinformatics method to analyze the expression profiling by high throughput sequencing in human bronchial organoids/primary human airway epithelial infected with SARS-CoV-2 to identify the potentially crucial genes and pathways associated with
COVID-19. A total of 145 differentially expressed genes and 5 hub genes consisting of
CXCL8, CXCL1, CXCL2, CCL20, and CSF2 were associated with infection linked immune response. These may be used as diagnostic biomarkers or molecular targets for the treatment of SARS-CoV-2.
·
Peng et al:
used TCMSP, SwissTargetPrediction, SEA, GeneCards, CTD, and TTD to identify potential targets for matrine in SARS-CoV-2. Ten common matrine targets were obtained, particularly including TNF-α, IL-6, and CASP3. GO and KEGG pathway enrichment analysis
revealed five significantly enriched signalling pathways involved in cell proliferation, apoptosis, programmed cell death, and immune responses.
PUBLIC HEALTH RESPONSE
·
Kumar et al.
conduct an online social media based survey among individuals who recovered from a COVID-19 infection or are in the recovery phase following infection. 54% of respondents reported being in fear of reinfection. Anxiety and depression appear as common
psychological complications following infection. Prevalence of these symptoms was associated with prolonged duration of COVID-19 infection related physical symptoms.
ECONOMICS
·
Dave et al
explore the impact of the annual motorcycle rally in Sturgis, South Dakota, on social distancing and the spread of COVID-19. Smartphone pings from non-residents, and foot traffic at local establishments each rose substantially in the census block groups
hosting Sturgis rally events. A month following the rally, COVID-19 cases increased by approximately 6 to 7 cases per 1,000 population in its home county of Meade. Estimates show that following the event, counties that contributed the highest inflows of rally
attendees experienced a 7.0 to 12.5% increase in COVID-19 cases relative to counties that did not contribute inflows. They estimate that the Sturgis Motorcycle Rally generated public health costs of as much as $12.2 billion.
Regards,
Lisa Waddell, Tricia Corrin, Rukshanda Ahmad, Robyn Odell, Maribeth Mitri, Julie Theriault, Dobrila Todoric, Alejandra Dubois, Christina Bancej, Austyn Baumeister, Anam Khan, Musaab Younis, Lien Mi Tien, Dima Ayache, Angela Sloan, Kaitlin
Young, Chatura Prematunge, Ainsley Otten, Irene Yong, Drew Greydanus, Shalane Ha, Alex Gilbert
Focus areas: Modelling/ prediction, Epidemiology, Transmission, Clinical data, Surveillance, Coronavirology, Diagnostics / Pathogen detection, Therapeutics,
Vaccine Research, Public health interventions, Public Health response, Public Health Priorities, IPAC, Health care response, immunology, economics, animal model, zoonoses, Review Literature, Commentary/Editorial, news
Domaines cibles: Modélisation/prédiction, Épidémiologie, Transmission, Données cliniques, Surveillance, Coronavirologie, Diagnostics
/ Détection d'agents pathogènes, Thérapeutique, Recherche sur les vaccins, Interventions de santé publique, Priorités de santé publique, PCI,
Réponse des soins de santé, immunologie, économie, modèle animal, zoonoses, Revue de littérature, Commentaire/Éditorial, journaux
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PUBLICATIONS |
AUTHORS / AUTEURS |
SOURCE |
FOCI / DOMAINE |
SUMMARY / SOMMAIRE |
COVID-19 related anxiety in children and adolescents with severe obesity: A mixed-methods study |
Abawi, O, Welling, et al |
Clin Obes |
Public Health response| Interventions de santé publique |
Using a combined quantitative and qualitative approach, we explored COVID-19 related anxiety in paediatric patients
with severe obesity in the Netherlands using semi-structured telephone interviews and the Paediatric Quality of Life Inventory (PedsQL) questionnaire, which had also been completed by the study population at baseline in the year prior to the COVID-19 outbreak.
Characteristics of included patients were: median age 10.5 years (interquartile range = 7.6-15.2); 52% female; mean BMI standard deviation score 3.8 (SD = 1.0). COVID-19 related anxiety was reported for 24/75 (32%) children. The mean decrease in PedsQL score
between baseline visit and COVID-19 outbreak did not differ between children for whom anxiety was reported vs those for whom it was not (mean change -10.3 ± 36.5 vs -3.3 ± 24.4, P = .54). Self-imposed strict quarantine measures were taken by 19/75 (25%) families.
During follow-up, several families reported that the previous contact alleviated their anxiety. In conclusion, healthcare professionals should address possible COVID-19 related anxiety in children with severe obesity. Addressing COVID-19 related anxiety could
mitigate its potential negative effects. |
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Reliable iterative methods for mathematical model of covid-19 based on data in anhui, china |
Abed, SM, Al-Jawary, et al |
Communications in Mathematical Biology and Neuroscience |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, five reliable iterative methods: Daftardar-Jafari method (DJM), Tamimi-Ansari method (TAM), Banach contraction method (BCM), Adomian decomposition
method (ADM) and Variational iteration method (VIM) to obtain approximate solutions for a mathematical model that represented the coronavirus pandemic (COVID-19 pandemic). The accuracy of the obtained results is numerically verified by evaluating the maximum
error remainder. In addition, the approximate results are compared with the fourth-order Runge-Kutta method (RK4) and good agreement have achieved. The convergence of the proposed methods is successfully demonstrated and mathematically verified. All calculations
were successfully performed with MATHEMATICA®10. © SCIK Publishing Corporation. All rights reserved. |
|
Abedin, Sumaiya, Khan, et al |
Research Square prepub |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
Apply panel generalized linear models for daily number of cases to explore differential effects of timing to and extent of widespread testing on daily
number of cases. We have analyzed daily number of confirmed cases data from the first reported cases in Australia and Italy to 31 May 2020. More tests during the early stage of outbreak prior to reach the peak may reduce the daily number of cases by almost
40%. Only 1% increase in test positivity on the (t-5)th day may incur 1.84% increase in daily number of cases on the t-th day. For 1% increase in test positivity rate on the (t-5)th day, a country with one unit higher logarithm of population density may result
in 2.82 times higher number of cases on the t-th day. Conclusion: Conducting widespread testing during the early stage prior to reaching the peak has favored Australia to control the outbreak much faster than Italy. Early adoption of widespread testing with
lower degree of test positivity rates flattens the curve faster. Population density has a moderating effect. Even if the test positivity rate is the same, a region with higher population density is likely to experience a peak with higher number of daily confirmed
cases. |
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Potential protease inhibitors and their combinations to block SARS-CoV-2 |
Abhinand, CS, Nair, et al |
J Biomol Struct Dyn |
Therapeutics| Thérapeutique |
The present study examines the possible repurposing of existing anti-viral protease inhibitor drugs. The results indicated that, Ritonavir has the highest
potency to block SARS-CoV-2 main protease and human TMPRSS2, a host cell factor that aids viral infection. Other drugs such as Indinavir and Atazanavir also showed favourable binding with Cathepsin B/L that helped viral fusion with the host cell membrane.
Further molecular dynamics simulation and MM-PBSA binding free energy calculations confirmed the stability of protein-drug complexes. These results suggest that protease inhibitors particularly Ritonavir, either alone or in combination with other drugs such
as Atazanavir, have the potential to treat COVID 19. |
|
Achilonu, I, Iwuchukwu, et al |
Journal of Molecular Graphics and Modelling |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Using 6Y2G and the prior knowledge that protease inhibitors could eradicate COVID-19, we designed a computational study aimed at identifying FDA-approved
drugs that could interact with Mpro. Using high-throughput virtual screening and ligand docking, we identified Isavuconazonium, a ketoamide inhibitor (α-KI) and Pentagastrin as the top three molecules (Lig13b as the benchmark) based on docking energy. |
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Australia can use population level mobility data to fight COVID-19 |
Adams, L, Adams, et al |
Med J Aust |
Public health interventions*| Interventions de santé publique |
We studied mobility data from major cities worldwide, including in Australia, and saw the pattern of decreased movement
in the population before stay-at-home orders consistently replicated. Across all 22 cities examined, movement below baseline was seen on average 13 days (median, 9 days) before government enforced stay‐at‐home orders. |
|
Addagarla, SK, Kalyan Chakravarthi, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Public health interventions*| Interventions de santé publique Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
In the era of deep learning, object detection plays an influential role for many industries. Detecting minute things
are very much essential without human intervention especially at large scale industries. In this paper we have proposed multiple approaches for Multi-scale facial mask real time detection and classification for the hospital industry, crowd surveillance in
the streets and malls are more useful in this COVID-19 Pandemic Situation. In our approach we have implemented two different detection models which are FMY3 using Yolov3 Algorithm and FMNMobile using NASNetMobile and Resnet_SSD300 Algorithms and used two different
face mask dataset with 680 and 1400 images respectively. We have analyzed both the models by computing various probabilistic accuracy measures and achieved the 34% Mean Average Precision (mAP) and 91.7% Recall rate on FMY3 Model and achieved the 98% and 99%
of accuracy and recall rate on FMNMobile Model. Finally we have shown results of various face mask detections from both the models. © 2020, World Academy of Research in Science and Engineering. All rights reserved. |
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Ahmad, S, Ullah, et al |
Advances in Difference Equations |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper, a novel coronavirus infection system with a fuzzy fractional differential equation defined in Caputo’s
sense is developed. By using the fuzzy Laplace method coupled with Adomian decomposition transform, numerical results are obtained for better understanding of the dynamical structures of the physical behavior of COVID-19. Such behavior on the general properties
of RNA in COVID-19 is also investigated for the governing model. The results demonstrate the efficiency of the proposed approach to address the uncertainty condition in the pandemic situation. © 2020, The Author(s). |
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Practice of Academic Surgical Pathology During the
COVID-19 Pandemic |
Ahmad, Z, Rahim, et al |
Am J Clin Pathol |
Healthcare Response | Réponse des soins de santé |
This study determined the impact of the coronavirus disease 2019 (COVID-19) pandemic on our service, pre-, and postgraduate
education and discussed the measures taken to ensure continued provision of quality service as well as education during the mandatory lockdown. Staggered rota was introduced for all staff. Strict social distancing measures were implemented. Staff was extensively
counseled regarding the importance of protective measures. Pre- and postgraduate education, which was temporarily suspended, was quickly resumed using online teaching ensuring continuation of academic activities. The volume of cases decreased during the lockdown
but complexity increased even more. |
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Covid‐19 in somalia: Adherence to preventive
measures and evolution of the disease burden |
Ahmed, MAM, Fodjo, et al |
Pathogens |
Public health interventions*| Interventions de santé publique Public Health response|
Interventions de santé publique |
Following the COVID‐19 outbreak in Somalia, strict preventive measures were implemented by the government. We assessed
adherence to the government recommendations via two consecutive online cross‐sectional surveys between April and July 2020. A five‐point adherence score was constructed based on self‐reported observance of five preventive measures (physical distancing, face
mask use, hand hygiene, mouth covering when coughing/sneezing, and avoidance of touching the face). 4124 and 4703 responses were analyzed during the first and second survey, respectively. The mean adherence score decreased from 3.54 ± 1.5 in the first survey
to 3.40 ± 1.6 during the second survey; p < 0.001. More participants experienced at least one flu‐like symptom during the second survey (38.2%) compared to the first (16.2%); however, the proportion of positive COVID‐19 tests in the first (26.9%) and second
survey (26.5%) was similar. The ordinal logistic regression model identified the following predictors for high adherence scores: female gender (odds ratio (OR) = 1.715 (1.581–1.861), p < 0.001); being a healthcare worker/student (OR = 2.180 (2.000– 2.377),
p < 0.001); obtaining COVID‐19 information from official sources (OR = 1.460 (1.341–1.589), p < 0.001); and having postgraduate education (OR = 1.679 (1.220–2.307), p < 0.001). Conversely, obtaining COVID‐19 information from social media and residing in urban
settings were associated with lower adherence. Targeted and context‐specific adaptations of the COVID‐19 response may be required in Somalia |
|
Ahmed, MS, Yunus, et al |
Int J Environ Health Res |
Public Health response| Interventions de santé publique |
The objective of the study was to assess the prevalence and factors associated with household (HH) handwashing practice
in Bangladesh and draw a trend of COVID-19 spreads and compare that with the countrywide HH handwashing practice.
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COVID-19 outbreak in Bangladesh and associated psychological problems: An online
survey |
Ahmed, O, Ahmed, et al |
Death Stud |
Public Health response| Interventions de santé publique |
The present study was conducted using self-rated scales on a sample of 500 Bangladeshi people to address this gap.
Results suggested two-fifths of the participants had depression and anxiety symptoms, and one-third were highly worried and felt stressed. Females, students, unmarried, and 18-30-year-olds were in more vulnerable positions in terms of their mental health.
These findings would be helpful to assess and formulate psychological interventions to improve the mental health of vulnerable groups. |
|
Akai, T, Maruyama, et al |
Interdiscip Neurosurg |
Clinical data| Données cliniques |
We report a 72-year-old woman who required urgent endonasal trans-sphenoidal surgery (eTSS) because of progressive
visual field disturbance due to pituitary adenoma, in whom we conducted reverse-transcriptase-polymerase-chain-reaction (RT-PCR) for COVID-19 and chest CT before eTSS. We took care of her by following the rule for suspected infection patient, and safely completed
her treatment without medical staff infection. Under COVID-19 pandemic state, essentially careful management including RT-PCR test and chest CT should be taken for the high infection risk surgeries to avoid the outbreak through the hospital. And the cost of
RT-PCR test for the patients should be covered by the government budget. |
|
|
Akiyama, T, Hirata, et al |
Nanomaterials |
Therapeutics| Thérapeutique Animal model | Modèle animal |
We hypothesise that a natural-mineral-based novel nanomaterial, which was developed based on nitric oxide (NO) therapy,
might be a viable strategy for the treatment and prevention of COVID-19. The intravascular NO concentration in the hepatic portal of rats was increased by 0.17 nM over 35.2 s on average after its application. An ultrasonic Doppler flow meter showed significant
increases in the blood flow rate and vessel diameter, but no difference in the blood flow velocity. |
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A case of non-severe COVID-19 complicated by pulmonary embolism |
Akiyama, Y, Horiuchi, et al |
Respirology Case Reports |
Clinical data| Données cliniques |
We report a case of non-severe COVID-19 complicated by pulmonary embolism, which indicates that the possibility of
pulmonary embolism should consistently be considered, even in non-severe cases of COVID-19 without any risk of thrombosis. |
|
Aldila, D |
Communications in Mathematical Biology and Neuroscience |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
The model constructed is based on a nonlinear system of ordinary differential equations. Analytical results regarding
the basic reproduction number and all equilibrium points are obtained analytically. We also found that indirect transmission contributes to the increases in the basic reproduction number and also the occurrence of the multiple endemic states. An optimal control
approach was applied to determine the best strategy for the COVID-19 eradication program. Three control parameters were considered in the model: medical mask, disinfectant, and medical treatment. A Pontryagin’s Maximum Principle was used to derive the optimal
control characterization of the related model and was solved numerically using the forward-backward iterative method. From the cost-effectiveness analysis, we found that using a medical mask as a single intervention is the most effective strategy to reduce
the spread of infection. |
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Knowledge and awareness on natural dietary immunoboosters to combat covid 19-a
survey |
Aldrin Joshua, A, Gayatri Devi, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
The main aim of the study is to create an awareness on natural dietary immunoboosters to combat COVID 19. The survey
was done on a small scale population comprising 110 participants in which 62 male (56.4%) and 48 female (43.6%) participated. About 95.5% of the population are aware that taking citrus fruits that have vitamin C will boost their immunity but only 4.5% of them
are not aware. 80% of the population are aware that green tea is a powerful antioxidant which will help in building immunity but 9.1% were not aware and 10.9% was not sure of the fact. 82.7% of the population are well aware that spinach and other green vegetables
have to be cooked as little as possible to retain nutrients present in them but only 10.9% of them were not sure and 6.4% of them were not aware. |
|
Prognostic significance of hemoglobin level and autoimmune hemolytic anemia in
SARS-CoV-2 infection |
Algassim, AA, Elghazaly, et al |
Ann Hematol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This cross-sectional study investigated the impact of initial hemoglobin (Hgb) levels at Emergency Department (ED)
triage on the severity and the clinical course of COVID-19 on 601 patients in a COVID-19 national referral center between 13 and 27 June 2020. Patients admitted to the intensive care unit (ICU) had a lower initial Hgb than those admitted outside the ICU (12.84
g/dL vs. 13.31 g/dL, p = 0.026) and over the course of admission; the prevalence of anemia (Hgb < 12.5 g/dL) was 65% in patients admitted to ICU, whereas it was only 43% in non-ICU patients (odds ratio of 2.464, 95% CI 1.71-3.52). Anemic ICU patients had a
higher mortality compared with non-anemic ICU patients (hazard ratio = 1.88, log-rank p = 0.0104). A direct agglutination test (DAT) for all anemic patients showed that 14.7% of ICU patients and 9% of non-ICU patients had autoimmune hemolytic anemia (AIHA).
AIHA patients had significantly longer length of hospital stay compared with anemic patients without AIHA (17.1 days vs. 14.08 days, p = 0.034). |
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PMC7476498; Lung point-of-care (POCUS) ultrasound in a pediatric COVID-19 case |
Alilio, PM, Ebeling-Koning, et al |
Radiol Case Rep |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We describe a case of a previously well, 9-year-old obese boy who presented to the emergency department with shortness
of breath, fever, abdominal pain, and cough with chest pain. He was diagnosed with COVID-19 through significant family contact. Lung point-of-care ultrasound (POCUS) in the emergency department observed significant lung pathology, including pleural thickening,
consolidation, and B lines. A chest X-ray found bilateral ground glass opacities and interstitial prominences consistent with viral pneumonia. Our case suggests that lung POCUS can provide adequate and rapid imaging to assess lung pathology of COVID-19 in
a pediatric patient. As there is limited literature on use of lung POCUS in pediatric patients infected with SARS-CoV-2, our case emphasizes its function as a potentially efficient modality in bedside assessment. |
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Almandoz, JP, Xie, et al |
Clin Obes |
Public Health response| Interventions de santé publique |
Impact of public health measures on obese people: A total of 123 patients (87% female, mean age 51.2 years SD 13.0]),
mean BMI 40.2 SD 6.7], 49.2% non-Hispanic white (NHW), 28.7% non-Hispanic black, 16.4% Hispanic, 7% other ethnicity and 33.1% completed MBS were included. Two patients tested positive for severe acute respiratory syndrome coronavirus 2 and 14.6% reported symptoms.
Then, 72.8% reported increased anxiety and 83.6% increased depression since stay-at-home orders were initiated. Also 69.6% reported more difficultly in achieving weight loss goals, less exercise time (47.9%) and intensity (55.8%), increased stockpiling of
food (49.6%) and stress eating (61.2%). Hispanics were less likely to report anxiety vs NHWs (adjusted odds ratios 0.16; 95% CI, 0.05-0.49; P = .009). Results here showed the COVID-19 pandemic is having a significant impact on patients with obesity regardless
of infection status. |
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Impact of lockdowns on the spread of COVID-19 in Saudi Arabia |
Alrashed, S, Min-Allah, et al |
Informatics in Medicine Unlocked |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Authors introduce a variable in the SEIR system of equations to study the impact of various degrees of social distancing
on the spread of the disease. Analysis shows that with no lockdown around 2.1 million people might get infected during the peak of spread around 2 months from the date the lockdown was first enforced in Kingdom of Saudi Arabia (KSA). |
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Synthesis of 3,3'-methylenebis(4-hydroxyquinolin-2(1H)-ones) of prospective anti-COVID-19
drugs |
Aly, AA, Hassan, et al |
Mol Divers |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
During formylation of 2-quinolones by DMF/Et3N mixture, the unexpected 3,3′-methylenebis(4-hydroxyquinolin-2(1H)-ones)
were formed. The structure of the obtained products was elucidated via NMR, IR and mass spectra. X-ray structure analysis proved the anti-form of the obtained compounds, which were stabilized by the formation hydrogen bond. Molecular docking calculations showed
that most of the synthesized compounds possessed good binding affinity to the SARS-CoV-2 main protease (Mpro) in comparable to Darunavir. |
|
Alyami, HS, Orabi, et al |
Saudi Pharmaceutical Journal |
Public Health response| Interventions de santé publique |
This study explored the knowledge of the population of the Kingdom of Saudi Arabia (KSA) about COVID-19 preventive
measures and their belief about the consumption of herbal products for the prevention of COVID-19 infection. Participants’ knowledge about the appropriate COVID-19 preventive measures in terms of handwashing procedures, self-quarantine and social distancing
was moderate. About 22.1% of the participants reported that they have used herbal products or nutritional supplements, particularly vitamin C, to protect themselves from the disease. |
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Al-Youbi, A, Al-Hayani, et al |
Sustainability (Switzerland) |
Economics | Économie |
The present study aimed to investigate the implications of COVID-19 on the labor market of Saudi Arabia. The results
indicate that the healthcare, service and education sectors have quickly transformed themselves from conventional to remote forms of working and consider virtual skills, autonomous working and effective communication the most important skills for their workforce
during the current and the postpandemic scenarios. |
|
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Massive subcutaneous emphysema in patient SARS-CoV-2 positive |
Amador Penco, FDB, Villalonga, et al |
Revista espanola de anestesiologia y reanimacion |
Clinical data| Données cliniques |
This case report describes a massive subcutaneous emphysema in a 77-year-old patient patient with SARS-CoV-2 infection,
hypertension and dyslipidaemia. The patient experienced multiorgan failure and death. |
|
Amalakanti, S, Raman Arepalli, et al |
Indian journal of medical microbiology |
Public Health response| Interventions de santé publique |
The aim of this study the CoViD 19 knowledge, attitude and practices (KAP) of a south Indian state population.
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|
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Prediction of the final size for COVID-19 epidemic using machine learning: A case
study of Egypt |
Amar, LA, Taha, et al |
Infectious Disease Modelling |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this paper displayed, the real database of COVID-19 for Egypt has been analyzed and predicted with the number of
patients that will be infected with COVID-19, and estimated the epidemic final size. The action from government of interevent over a relatively long interval is necessary to minimize the final epidemic size. |
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Symptomatic pericardial effusion in the setting of asymptomatic COVID-19 infection:
A case report |
Amoozgar, B, Kaushal, et al |
Medicine (Baltimore) |
Clinical data| Données cliniques |
Here we present a rare case of pericardial effusion in the setting of asymptomatic COVID-19 infection manifesting with
the chief complaint of chest pain. |
|
Angelini, V, Villanacci, et al |
Egyptian Journal of Radiology and Nuclear Medicine |
Clinical data| Données cliniques |
Case report of a 60 year old male |
|
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Anuratha, K, Parvathy, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Public Health response| Interventions de santé publique |
The entire world is affected because of the global pandemic Covid-19 due to the virus belongs to the family of Coronavirus.
As the spread of infection and mortality rate is rapid people have started developing assorted emotions about the crisis. It is more significant to administer the mental health and Psychological wellbeing of public during a crisis like this. As many of the
people broadly use the social media like twitter for sharing their opinions and thoughts, our work utilizes the Covid specific Tweets posted by the Tweeple and analyse them to understand the sentiments exhibited regarding the situation. After the tweets are
collected and the real sentiments behind them are discovered using the classifier model developed using the Machine Learning methods. The experimental results may be used by the respective authorities to take necessary initiatives for addressing the concerns
that affect the wellbeing of the society and the economic wellbeing as well. As our word uses Lexical based sentiment analysis, it is important to remove the ambiguities of a word which is a main challenge of this technique on sentiment analysis. To improve
the performance of the Sentiment Analysis we have used the lexical dictionaries Wordnet and SentiWordNet along with Word Sense Disambiguation (WSD) to detect and remove the ambiguities understanding the context of the term used in the tweets. © 2020, World
Academy of Research in Science and Engineering. All rights reserved. |
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Araten, DJ, Belmont, et al |
Am J Case Rep |
Clinical data| Données cliniques |
Theses case reports tries to address the question of whether patients on anti-complement therapy could be protected
from COVID-19. CASE REPORT Case 1 is a 39-year-old woman with an approximately 20-year history of paroxysmal nocturnal hemoglobinuria (PNH), who had recently been switched from treatment with eculizumab to ravulizumab prior to SARS-CoV-2 infection. Case 2
is a 54-year-old woman with a cadaveric renal transplant for lupus nephritis, complicated by thrombotic microangiopathy, who was maintained on eculizumab, which she started several months before she developed the SARS-CoV-2 infection. Case 3 is a 60-year-old
woman with a 14-year history of PNH, who had been treated with eculizumab since 2012, and was diagnosed with COVID-19 at the time of her scheduled infusion. All 3 patients had a relatively mild course of COVID-19. |
|
|
Araujo, OR, Almeida, et al |
Pediatr Crit Care Med |
Healthcare Response | Réponse des soins de santé |
To study the impact of the coronavirus disease 2019 pandemic, considering the physical distancing and schools closing,
on the characteristics of admission and epidemiology on Brazilian PICUs.Observational, multicenter, time series analysis, of electronic medical records from 15 PICU in Brazil. The period from March 11, 2020, to March 17, 2020, was considered the "intervention
point" studied, corresponding to the suspension of school activities and the beginning of physical distancing in Brazil. The coronavirus disease 2019 pandemic strongly affected Brazilian PICUs, reducing admissions, length of stay, and the epidemiological
profile. The measures to oppose the coronavirus disease 2019 pandemic may have prevented thousands of PICU hospitalizations across the country. |
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|
Arshad, Y, Mahmood, et al |
Journal of Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
From June 6 through June 28, 2020, a total of 35 suspected COVID-19 patients were enrolled for the study and both conjunctival
and oropharyngeal swabs samples were collected from all patients admitted in the isolation ward of a tertiary care hospital, Pakistan Institute of Medical Sciences-(PIMS) Islamabad. All 35 oropharyngeal swab samples were detected positive for SARS CoV-2, however
out of total 35 conjunctival swab samples, 3(8.5%) were detected positive by using real-time RT-PCR. 2(66%) out of 3 conjunctival SARS-Cov-2 positive patients were having dry cough, whereas 3(100%) patients were suffering from fever and difficulties in breathing.
There was no ocular manifestation observed among patients with positive conjunctival specimens and similar information has already been reported by the previous study. |
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Knowledge and awareness about low COVID-19 mortality rate in Germany-A survey |
Arun Kishore, RN, Gayatri Devi, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
The main aim of this study is to assess the knowledge and awareness about the mystery behind the low Covid 19 Germany
population Among south Indian population. From the results obtained and analysed the majority of the participants knew about the symptoms of COVID-19 and precautionary measures that had to be taken. The participants also have knowledge of Germans’ low mortality
rates during Covid 19 pan-demic. From this survey, we can conclude that the Chennai population does have knowledge and awareness about the mystery behind low COVID-19 Germans mortality rates. |
|
Ashik, AI, Hasan, et al |
Heliyon |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins Immunology
| Immunologie |
This study is focused on immunoinformatics analyses of the SARS-CoV-2 spike glycoprotein (S protein) which is key for
the viral attachment to human host cells. |
|
|
Aswathy, SU, Jarin, et al |
International Journal of Pharmaceutical Research |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
This study will show how Machine Learning technique can be used for classifying the infected and healthy lung using
the nano scaling imaging technique of computed tomography (CT) lung scans. Pre-processing is used to reduce the effect of intensity variations and for noise removal between CT slices. Then thresholding and other morphological operation is used to separately
isolate the background of the CT lung scan. Each dataset that we take undergoes a texture-based feature extraction method in which it uses GLCM along with a wrapper method for optimization. The obtained features are classified using a Deep convolutional neural
network, which will classify in several layers. By giving our input of scan images it will train in an efficient manner and gives us an accuracy of 99%. |
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VacSIM: Learning Effective Strategies for COVID-19 Vaccine Distribution using Reinforcement
Learning |
Awasthi, Raghav, Guliani, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
Vaccines are expected to be a limited resource. An optimal allocation strategy, especially in countries with access
inequities and a temporal separation of hot-spots might be an effective way of halting the disease spread. We approach this problem by proposing a novel pipeline VacSIM that dovetails Actor-Critic using Kronecker-Factored Trust Region (ACKTR) model into a
Contextual Bandits approach for optimizing the distribution of COVID-19 vaccine. Whereas the ACKTR model suggests better actions and rewards, Contextual Bandits allow online modifications that may need to be implemented on a day-to-day basis in the real world
scenario. We evaluate this framework against a naive allocation approach of distributing vaccine proportional to the incidence of COVID-19 cases in five different States across India and demonstrate up to 100,000 additional lives potentially saved and a five-fold
increase in the efficacy of limiting the spread over a period of 30 days through the VacSIM approach. We also propose novel evaluation strategies including a standard compartmental model based projections and a causality preserving evaluation of our model. |
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Resetting the Initial Conditions for Calculating Epidemic Spread: COVID-19 Outbreak
in Italy |
Babac, MB, Mornar, et al |
IEEE Access |
Epidemiology| Épidémiologie |
Authors have used the recent findings about the clinical courses of inpatients with COVID-19 to reset the initial conditions
of the epidemic process in order to estimate more realistic number of cases in the population. |
|
Balani, Prashant, Bhuiyan, et al |
Research Square prepub |
Clinical data| Données cliniques |
This case report emphasises that a patient with early detection and management of acute mesenteric ischaemia being
symptomatic for COVID 19 can avoid major bowel surgery and negate any morbidity or mortality associated with the condition. |
|
|
Barik, S, Paul, et al |
Knee Surg Sports Traumatol Arthrosc |
Healthcare Response | Réponse des soins de santé |
This study focusses on the viewpoint of the orthopedic residents to the paradigm shift in clinical care as well as
the academic activities. The online-based learning process was reported to be easier (44.2%) by most of the residents. Routine clinical work in the operating room, out-patient department, and inpatient department was found to be difficult according to the
majority of the residents along with the anxiety of contracting the infection. |
|
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Smell and taste disorders in Spanish patients with mild COVID-19 |
Barón-Sánchez, J, Santiago, et al |
Neurologia |
Clinical data| Données cliniques |
This study aimed to investigate the clinical progression of smell and taste disorders in Spanish patients with mild
COVID-19. In our sample, 91.18% of respondents with impaired smell and/or taste and who were able to undergo PCR testing were positive for SARS-CoV-2 infection. Olfactory and gustatory disorders are prevalent symptoms in mild COVID-19. Most patients do not
present associated nasal congestion or rhinorrhoea. |
|
Clinical and laboratory features of COVID-19: Predictors of severe prognosis |
Bastug, A, Bodur, et al |
International immunopharmacology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Background: Coronavirus disease 2019 (COVID-19) emerged first in December 2019 in Wuhan, China and quickly spread throughout
the world. Clinical and laboratory data are of importance to increase the success in the management of COVID-19 patients. Methods: Data were obtained retrospectively from medical records of 191 hospitalized patients diagnosed with COVID-19 from a tertiary
single-center hospital between March and April 2020. Prognostic effects of variables on admission among patients who received intensive care unit (ICU) support and those who didn't require ICU care were compared. Results: Patients required ICU care (n = 46)
were older (median, 71 vs. 43 years), with more underlying comorbidities (76.1% vs. 33.1%). ICU patients had lower lymphocytes, percentage of large unstained cell (%LUC), hemoglobin, total protein, and albumin, but higher leucocytes, neutrophils, neutrophil–lymphocyte
ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocytes ratio (PLR), urea, creatinine, aspartate amino transferase (AST), lactate dehydrogenase (LDH), and D-dimer when compared with non-critically ill patients (p < 0.001). A logistic regression
model was created to include ferritin, %LUC, NLR, and D-dimer. %LUC decrease and D-dimer increase had the highest odds ratios (0.093 vs 5.597, respectively) to predict severe prognosis. D-dimer, CRP, and NLR had the highest AUC in the ROC analysis (0.896,
0.874, 0.861, respectively). Conclusions: The comprehensive analysis of clinical and admission laboratory parameters to identify patients with severe prognosis is important not only for the follow-up of the patients but also to identify the pathophysiology
of the disease. %LUC decrease and D-dimer, NLR, and CRP increases seem to be the most powerful laboratory predictors of severe prognosis. © 2020 Elsevier B.V. |
|
Letter: severe COVID-19 infection and biologic therapies—a cohort
study of 7 808 patients in France |
Bataille, P, Amiot, et al |
Alimentary Pharmacology and Therapeutics |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Patients receiving biologics are at higher risk of developing serious infectious adverse events. The authors conducted
a multicentre observational study to determine the impact of biologics on the rate of hospitalisations, intensive care unit (ICU) admis-sions and deaths related to COVID-19. A total of 48 patients with biologic agent had confirmed COVID-19; 26 (54%) women
with a median age of 38 (IQR25-75 27.25-57). Most patients received an anti-TNF- (n = 39, 81%), 3 (6%) an IL-12/23 inhibitor, 2 (4%) an IL-17 inhibitor and 4 (9%) an 4ß7 integrin antibody. The main underlying diseases were IBD (n = 24, 50%), inflammatory
rheumatism (n = 12, 25%) and psoriasis (n = 3, 6%). A total of 19 (40%) patients were hospitalised, 4 (8%) were transferred to an ICU and one died. These results are consistent with earlier reports and reinforce the message that biologics can usually be safely
continued. |
|
Bates, BR, Moncayo, et al |
J Community Health |
Public Health response| Interventions de santé publique |
Participants had moderate to high levels of knowledge. Participants expressed mixed attitudes about the eventual control
of COVID-19 in Ecuador. Participants reported high levels of adoption of preventive practices. Binomial regression analysis suggests unemployed individuals, househusbands/housewives, or manual laborers, as well as those with an elementary school education,
have lower levels of knowledge. Women, people over 50 years of age, and those with higher levels of schooling were the most optimistic. Men, individuals 18–29, single, and unemployed people took the riskiest behaviors. Generally, knowledge was not associated
with optimism or with practices. |
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A framework of computational model for predicting the spread of COVID-19 pandemic
in Saudi Arabia |
Baz, A, Alhakami, et al |
International Journal of Intelligent Engineering and Systems |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Responding to the compelling contingency of COVID-19 pandemic, this research pursuit intends to develop a computational
model that can be used to gauge the spread of Coronavirus and predict the most vulnerable regions that are likely to be affected by it. Furthermore, the framework of the model also analyzes the impact of Coronavirus on various societal factors. Once identified,
these factors can be prioritized so as to device accurate and efficient countermeasures. For developing the expected model, the study has adopted the Fuzzy-AHP technique of computational modeling. Moreover, a decision making technique and severity analysis
technique along with the prioritization Fuzzy-AHP approach has been employed to validate the efficacy of the suggested model. Through rigorous study of different models of COVID-19, the proposed framework provides the best model to use according to the social
factors prevalent in a country. After evaluation through fuzzy AHP, the priority of proposed model is found to be the highest amongst the seven other models used for comparison. Though the present study is aimed at adding to the government's initiatives to
counter the current health emergency in the Kingdom of Saudi Arabia, the proposed computational model can be an effective aid for the specialists across the world working on containment strategies to minimise the spread of Coronavirus. |
|
Beck, MJ, Hensher, et al |
Transp Policy (Oxf) |
Public Health response| Interventions de santé publique |
This paper is the second in what will be an ongoing series of analyses of a longitudinal travel and activity survey.
In this paper we examine data collected over a period of late May to early June in Australia, following four-to-six weeks of relatively flat new cases in COVID-19 after the initial nationwide outbreak, as many state jurisdictions have begun to slowly ease
restrictions designed to limit the spread of the SARS-CoV-2 virus. We find that during this period, travel activity has started to slowly return, in particular by private car, and in particular for the purposes of shopping and social or recreational activities.
Respondents indicate comfort with the idea of meeting friends or returning to shops, so authorities need to be aware of potential erosion of social distancing and appropriate COVID-safe behaviour in this regard. There is still a concern about using public
transport, though it has diminished noticeably since the first wave of data collection. We see that working from home continues to be an important strategy in reducing travel and pressure on constrained transport networks, and a policy measure that if carried
over to a post-pandemic world, will be an important step towards a more sustainable transport future. |
|
|
Bedi, Punam, Shivani, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This paper proposes a Modified SEIRD (Susceptible-Exposed-Infected-Recovered-Deceased) model for projecting COVID-19
infections in India and its five states having the highest number of total cases. In this model, exposed compartment contains individuals which may be asymptomatic but infectious. Deep Learning based Long Short-Term Memory (LSTM) model has also been used in
this paper to perform short-term projections. The projections obtained from the proposed Modified SEIRD model have also been compared with the projections made by LSTM for next 30 days. The epidemiological data up to 15th August 2020 has been used for carrying
out predictions in this paper. These predictions will help in arranging adequate medical infrastructure and providing proper preventive measures to handle the current pandemic. The effect of different lockdowns imposed by the Indian government has also been
used in modelling and analysis in the proposed Modified SEIRD model. The results presented in this paper will act as a beacon for future policy-making to control the COVID-19 spread in India. |
|
|
Belciug, S, Bejinariu, et al |
Advances in Electrical and Computer Engineering |
Healthcare Response | Réponse des soins de santé |
The aim of this study is to explore how artificial immune system approaches for a multiqueuing model may aid the hospital
managers improve their resources. The proposed system outlines the route of Covid-19 patients in the intensive care unit (ICU), the compartmental model proposes a reasonable composition of the ICU, considering the queuing parameters, while the artificial immune
system optimizes the needed resources (beds plus associated costs). |
|
|
Bergrath, S, Aretz, et al |
BioMed research international |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
All resuscitation room patients between March 1st and April 15th 2020 were included in this retrospective study. Every
patient with suspicion of SARS-CoV-2 infection received a pharyngeal swab for rt-PCR, divided in the clinical subgroups of "highly suspicious for COVID-19" and "COVID-19 as differential diagnosis." Ninety-five patients were included (trauma n = 14, critically
ill n = 81). Of 3 highly suspicious patients, 2 had rt-PCR positive pharyngeal swabs. In 39 patients, COVID-19 was defined as differential diagnosis, and 3 were positive for SARS-CoV-2. Of them, pharyngeal swabs were positive in 1 case, while in 2 cases, only
tracheal fluid was rt-PCR positive while the pharyngeal swabs were negative. In one of these 2 cases, chest computed tomography (CT) was also negative for ground-glass opacities but showed a pulmonary abscess and pulmonary embolism. |
|
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Strategy for the Practice of Spine Oncological Surgery During the Covid-19 Pandemic |
Berjano, P, Vanni, et al |
Spine (Phila Pa 1976) |
Healthcare Response | Réponse des soins de santé |
An expert panel with general spine surgeons, oncological spine surgeons, and radiation oncologists was formed to analyze
the most frequent scenarios in spinal musculoskeletal oncology during Covid-19 pandemics. For each of the most frequent clinical scenarios, the authors reached a consensus on how timing and indications can be optimized to reduce risk while maintaining the
expected outcomes under the Covid-19 pandemics. |
|
Best, LA, Law, et al |
Canadian Psychology |
Public Health response| Interventions de santé publique |
In this study, questionnaire data measuring satisfaction with life, social cohesion, psychological distress, and perceptions
of risk was collected from 1381 Canadians during the early days of intense public health measures (31 March through 15 April 2020). Results suggest that even short-term social distancing practices are associated with increased psychological distress, including
elevated levels of overall distress, such as panic, emotional disturbances, and depression. These results are noteworthy for several reasons: the timing of the distress, the population under investigation, and the fact that the applied mitigation was "lighter"
than full quarantines previously studied. These findings suggest that after only a short period of time, less restrictive public health measures can lead to psychological distress. These results have major significance for government officials in future public
health crisis as they judiciously weigh the costs and benefits of applying such measures with various public health guidelines discussed. |
|
|
Lock-down for COVID-19 in India: An alternative viewpoint and revised epidemiological
estimates |
Bhalwar, R |
Pravara Medical Review |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
an effort was made to develop an alternative epidemiological model to forecast the likely course of the epidemic in
our country and to dispassionately analyze the effects of 10 weeks of lockdown. Material and Methods: Data for the period 8th May to 14th June regarding cases detected on that day and cumulative number of cases till that date, cases who reached “end-point”
on that day and cumulative number till that day, and deaths on that day as well as cumulative deaths till that day was obtained. The data was subjected to “time-series analysis” and parameters were calculated by linear regression, using the WHO / CDC statistical
package (Epi-7). Results: The study indicated that the “ratio of cumulative total of cases detected: cumulative cases who reached end point” and the ratio of “cases detected on that day: cases who reached end point (cured / discharged/died) on that day”, would
reach unity (indicating a “stabilization” of the epidemic) between 16th July and 01st August 2020. At that point of time, the cumulative total number of cases detected till that day are likely to be 11,80,000 (95% CL 10,74,368 to 12,41,768). The cumulative
total number of deaths which would occurred till that day are likely to be 20,000 (95% CL 18,800 to 21,200), while the number of new cases detected on a given day by then, are likely to be 23,000 (95% CL 22,000 to 24,000). |
|
Bibi, N, Gul, et al |
European journal of pharmacology |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In the present study, we have tried to decipher the mechanistic aspects of existing medicines at the viral entry and
replication stage via the structural viroinformatics approach. Here we implied the molecular docking and dynamic simulations with emphasis on the unique structural properties of host receptor angiotensin-converting enzyme 2 (ACE2), SARS-CoV2 spike protein
and RNA dependent RNA polymerase enzyme (RdRp) of the SARS-CoV2. Deep structural analysis of target molecules exposed key binding residues and structural twists involved in binding with important pharmacophore features of existing drugs (7-chloro-N-5-(diethylamino)pentan-2-yl]quinolin-4-amine
(chloroquine),N-4-(4-methylpiperazin-1-yl)phenyl]methyl]-1,2-oxazole-5-carboxamide N-4-(4-methylpiperazin-1-yl)phenyl]methyl]-1,2-oxazole-5-carboxamide) (SSAA09E2), 2-ethylbutyl (2S)-2-{(S)-{(2R,3S,4R,5R)-5-{4-aminopyrrolo2,1-f]1,2,4]triazin-7-yl}-5-cyano-3
(remdesivir) and 6-Fluor-3-oxo-3,4-dihydro-2-pyrazincarboxamid (favipiravir)]. It is evident from this structural informatics study that combo of chloroquine + SSAA09E2 with remdesivir or favipiravir could significantly restrain the virus at the entry and
replication stage. |
|
|
PMC7456189; Meckel's diverticulum perforation
in a newborn positive to Sars-Cov-2 |
Bindi, E, Cruccetti, et al |
J Pediatr Surg Case Rep |
Clinical data| Données cliniques |
In this paper we present a case of neonatal infection which, as far as we know, represents one of the few published
cases and which occurred in a patient who came to our attention for acute abdomen from intestinal perforation. The perforation was caused by Meckel's diverticulum, an event considered infrequent in the first year of life and almost exceptional in the neonatal
period. |
|
Bisht, K, Pant, et al |
International Journal of Current Research and Review |
Coronavirology| Coronavirologie Immunology | Immunologie |
Objective: One of the best ways to counter any pathogen including SARS-CoV-2 is through enhancement of self-immune
response. Tetherin or BST2 is one such interferon-induced antiviral protein or immune regulatory protein of the human host that can restrict the release of virions of SARS-CoV-2. The ORF7a encoded protein of SARS-CoV-2 in-turn has been found to act as an antagonist
to the human tetherin protein by interacting with key amino acid residues, thereby weakening the immune response. Methods: In this research after consensus analysis of results from various servers mutations have been induced in selected residues of ORF7a coronavirus
protein. Most conserved residues have been obtained through Consurf server, ligand binding pockets, and active sites have been identified after combining results from multiple servers like CastP and 3DLigand Site. Results: The most deleterious mutation has
been identified through DUET and DynaMut servers and mutations induced thereafter have been tested for a decrease in binding affinity through the HawkDock server. The protein-protein interaction studies have been performed before and after the induction of
mutation through the HawkDock server. Conclusions: The decrease in binding affinity between human tetherin and ORF7a protein is supportive of the need to study the induction of mutation and its detrimental effect on viruses, so that effective combat study
can be designed with the interplay of our native immune system and drugs from external sources. Moreover, other deterrents like anti-viral peptides can be designed against selected amino acids. © IJCRR. |
|
|
Bisht, RK, Jasola, et al |
Asian Education and Development Studies |
Public Health response| Interventions de santé publique |
There are two main objectives of the paper: the first one is to know the acceptability of online mode of examination
and learning amongst students by analysing the various aspects like difficulty, mental pressure, study pattern, etc. and the second one is to know the role of gender in adopting online education. The two main findings of the present study are as follows: first,
the online examinations were accepted with ease and low pressure in comparison to regular examination and second, the gender has a significant role in adopting online education with the observations that female students were more adoptable with online education
in terms of assignments, study patterns and comfort. |
|
|
Bizopoulos, Paschalis, Vretos, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper, an extensive comparison of DL models for lung and COVID-19 lesion segmentation in Computerized Tomography
(CT) scans is presented, which can also be used as a benchmark for testing medical image segmentation models. Three experimental setups are conducted for lung segmentation, lesion segmentation and lesion segmentation using the original lung masks. A public
COVID-19 dataset with 100 CT scan images (80 for train, 20 for validation) is used for training/validation and a different public dataset consisting of 829 images from 9 CT scan volumes for testing. Multiple findings are provided including the best architecture-encoder
models for each experiment as well as mean Dice results for each experiment, architecture and encoder independently. Finally, the upper bounds improvements when using lung masks as a preprocessing step or when using pretrained models are quantified. |
|
|
The influence of COVID-19 on routine hematological parameters of hospitalized
patients |
Blomme, S, Smets, et al |
Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study evaluated routine hematology parameters in time after admission. Data from routine blood analyses from confirmed
COVID-19 cases admitted to the University Hospital of Leuven in Belgium were collected. Deceased COVID-19 patients had significant lower platelet count, higher leukocyte/neutrophil count, and lower eosinophil/lymphocyte/monocyte count compared to recovered
patients. Especially lymphocyte count showed important differences; they were significantly lower between day 9 and 12 after admission making this time window important in predicting clinical worsening of a patient. Patients with COVID-19 with poor outcome
showed significant differences in results of routine hematological parameters compared with patients that recovered. |
|
Universal screening for COVID-19 in children undergoing orthopaedic surgery:
A multicenter report |
Blumberg, TJ, Adler, et al |
Journal of Pediatric Orthopaedics |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
This study examines the results of universal screening on children undergoing orthopaedic surgery. In total, 1198
patients underwent preoperative screening across all 3 institutions and 7 (0.58%) had detection of SARS-CoV-2. The majority of patients (1/7, 86%) were asymptomatic. Patients that tested positive were significantly more likely to be Hispanic (P=0.046) and
had greater number of medical comorbidities (P=0.013), as scored on the American Society of Anesthesiologists (ASA) physical status score. A known COVID-19 positive contact was found to be a significant risk factor in the multivariate analysis (P=0.004). |
|
In-hospital mortality in heart failure in Germany during the Covid-19
pandemic |
Bollmann, A, Hohenstein, et al |
ESC Heart Fail |
Healthcare Response | Réponse des soins de santé |
AIMS: The Covid-19 pandemic affects care for cardiovascular conditions, but data on heart failure (HF) are scarce.
This study aims to analyse HF care and in-hospital outcomes during the pandemic in Germany. METHODS AND RESULTS: A total of 9452 HF admissions were studied using claims data of 65 Helios hospitals; 1979 in the study period (13 March 30 April 2020) and 4691
and 2782 in two control periods (13 March to 30 April 2019 and 1 January to 12 March 2020). HF admissions declined compared with both control periods by 29-38%. Cardiac resynchronization therapy was implanted in 0.55% during the study period, 0.32% in the
previous year and 0.43% in the same year control. Intensive care treatment was 6.22% during the study period, 4.49% in the previous year, and 5.27% in the same year control. Length of hospital stay was 7.0 ± 5.0 days in the study and 7.8 ± 5.6 and 7.3 ± 5.1
days in the control periods. In-hospital mortality was 7.0% in the study and 5.5% in both control periods. |
|
Bonful, HA, Addo-Lartey, et al |
PLoS One |
Public health interventions*| Interventions de santé publique Healthcare Response |
Réponse des soins de santé |
We conducted an exploratory observational study to assess compliance with these recommendations in selected transportation
stations in Ghana. A one-hour audit of 45 public transport stations in the Greater Accra region was carried out between 27th and 29th March 2020. Using an adapted World Health Organization (WHO) hand hygiene assessment scale, the availability and use of handwashing
facilities, social distancing, and ongoing public education on COVID-19 prevention measures were assessed, weighted and scored to determine the level of compliance of stations. Compliance with recommendations was categorized as "inadequate" "basic", "intermediate"
and "advanced", based on the overall score. Majority (80%) of stations in Accra have at least one Veronica Bucket with flowing water and soap, but the number of washing places at each station is not adequate. Only a small minority (18%) of stations were communicating
the need to wash hands frequently and appropriately, and to practice social/physical distancing while at the station. In most stations (95%), hand washing practice was either not observed, or only infrequently. Almost all stations (93%) did not have alcohol-based
hand sanitizers available for public use, while social distancing was rarely practiced (only 2%). In over 90% of the stations, face masks were either not worn or only worn by a few passengers. Compliance with COVID-19 prevention measures was inadequate in
13 stations, basic in 16 stations, intermediate in 7 stations, and advanced in 9 stations. Compliance with COVID-19 prevention measures in public transportation stations in the Greater Accra region remains a challenge. Awareness creation should aim to elevate
COVID-19 risk perception of transportation operators and clients. Transport operators and stations need support and guidance to enforce hand washing and social distancing. |
|
|
Accelerating COVID-19 Differential Diagnosis with Explainable Ultrasound Image Analysis |
Born, Jannis, Wiedemann, et al |
arXiv |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We provide the largest publicly available lung ultrasound (US) dataset for COVID-19 consisting of 106 videos from three
classes (COVID-19, bacterial pneumonia, and healthy controls); curated and approved by medical experts. On this dataset, we perform an in-depth study of the value of deep learning methods for differential diagnosis of COVID-19. We propose a frame-based convolutional
neural network that correctly classifies COVID-19 US videos with a sensitivity of 0.98+-0.04 and a specificity of 0.91+-08 (frame-based sensitivity 0.93+-0.05, specificity 0.87+-0.07). We further employ class activation maps for the spatio-temporal localization
of pulmonary biomarkers, which we subsequently validate for human-in-the-loop scenarios in a blindfolded study with medical experts. Aiming for scalability and robustness, we perform ablation studies comparing mobile-friendly, frame- and video-based architectures
and show reliability of the best model by aleatoric and epistemic uncertainty estimates. |
|
Evolving Impact of COVID-19 on Transplant Center Practices and Policies
in the United States |
Boyarsky, BJ, Ruck, et al |
Clin Transplant |
Healthcare Response | Réponse des soins de santé |
Transplant Centers: We therefore conducted a six-week follow-up survey May 7-15, 2020 and linked responses to the COVID-19
incidence map, with a response rate of 84%. Suspension of live donor transplantation decreased from 72% in March to 30% in May for kidneys and from 68% to 52% for livers. Restrictions/suspension of deceased donor transplantation decreased from 84% to 58% for
kidneys and from 73% to 42% for livers. Resuming transplantation at normal capacity was envisioned by 83% of programs by August 2020. Exclusively using local recovery teams for deceased donor procurement was reported by 28%. Respondents reported caring for
a total of 1,166 COVID-19-positive transplant recipients; 25% were critically ill. Telemedicine challenges were reported by 81%. |
|
Acute deep vein thrombosis in COVID 19 hospitalized patients. Risk factors and clinical
outcomes |
Bozzani, A, Tavazzi, et al |
Phlebology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of the study was to analyse the risk factors and clinical outcomes of COVID-19 patients who developed deep
vein thrombosis during hospitalization in the acute phase of the outbreak in Lombardia- Italy. |
|
Brosnahan, SB, Bhatt, et al |
Chest |
Clinical data| Données cliniques |
New York City that are related to increased rates of thrombotic events in patients re-presenting to health care within
a short timeframe after an index COVID-19 admission. All 9 patients re-presented within eight days of discharge, which echoes prior studies that depict that the highest risk for thrombosis after hospitalization for a medical illness occurs within nine days.20
This shows that the postdischarge thrombosis risk in COVID-19 seems to behave similar to other medical admission thrombosis. |
|
|
Exploring Automatic Diagnosis of COVID-19 from Crowdsourced Respiratory Sound Data |
Brown, C, Chauhan, et al |
|
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
In this paper, the authors describe results from a large-scale crowdsourced dataset of respiratory sounds collected
to aid diagnosis of COVID-19. Used coughs and breathing to understand how discernible COVID-19 sounds are from those in asthma or healthy controls. Results show that even a simple binary machine learning classifier is able to classify correctly healthy and
COVID-19 sounds. Also show how we distinguish a user who tested positive for COVID-19 and has a cough from a healthy user with a cough, and users who tested positive for COVID-19 and have a cough from users with asthma and a cough. |
|
Replicating and projecting the path of COVID-19 with a model-implied reproduction
number |
Buckman, SR, Glick, et al |
Infectious Disease Modelling |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Authors demonstrate a methodology for replicating and projecting the path of COVID-19 using a simple epidemiology model.
They show that declines in measures of population mobility tend to precede declines in the model-implied reproduction numbers for each country. |
|
Bui, TQ, Phuong Loan, et al |
RSC Advances |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The inhibitory capabilities of the carbene complexes (NHC-Ag and NHC-Ag-bis) and the two potential drugs (ribavirin
and remdesivir) on human-protein ACE2 and SARS-CoV-2 protease PDB6LU7 were evaluated using molecular docking simulation. The present study suggests that silver-carbene NHC-Ag and bis-silver-carbene NHC-Ag-bis complexes are potential candidates to inhibit ACE2
and PDB6LU7, and thus potentially conducive to prevent infection caused by the SARS-CoV-2 virus. |
|
|
Patterns of Policy Responses to the COVID-19
Pandemic in Federal vs. Unitary European Democracies |
Buthe, Tim, Barceló, et al |
SSRN- Lancet prepublication |
Public Health response| Interventions de santé publique |
Using both statistical and qualitative case study methods, we analyse national and sub-national policy responses to
COVID-19 in 2 federal (Germany and Switzerland) and 2 unitary countries (France and Italy). We find that overall, federal countries are more likely to possess heterogeneity in their policy responses than unitary countries. We find mixed evidence as to whether
federal or unitary countries' policies are more responsive to the severity of the COVID-19 crisis at the sub-national level. |
|
Saliva Alternative to Upper Respiratory Swabs for SARS-CoV-2 Diagnosis |
Byrne, RL, Kay, et al |
Emerg Infect Dis |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
PCR of upper respiratory specimens is the diagnostic standard for severe acute respiratory syndrome coronavirus 2 infection.
However, saliva sampling is an easy alternative to nasal and throat swabbing. Overall, 12 (10.9%) saliva and 14 (12.7%) nasal and throat swab specimens of 110 paired samples tested positive for SARS-CoV-2 RNA. Viral loads for all samples ranged from 36 to
3.3 × 106 copies/mL. Overall viral loads were similar among all positive samples. |
|
32871183; Immunocytometric analysis of COVID patients: A contribution to personalized
therapy? |
Cacciapuoti, S, De Rosa, et al |
Life Sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aims to cast light on immunocytometric alterations in COVID-19, a potentially fatal viral infection with
heterogeneous clinical expression and a not completely defined pathophysiology. At hospital admission, total lymphocytes and most T and B subpopulations were reduced in 50–80% of the 35 studied patients patients, with close relationship to disease severity.
Immunocytofluorimetric markers may contribute to a personalized therapy in COVID patients. |
|
Evolving Otolaryngology Resident Roles and Concerns at the Peak of the US COVID-19 Pandemic |
Cai, Y, Gulati, et al |
Head Neck |
Healthcare Response | Réponse des soins de santé |
The roles of US otolaryngology residents have changed in response to the coronavirus disease 2019 (COVID-19) pandemic.
Authors characterized resident activities and concerns as the pandemic peaked in the US. |
|
Callo, EC, Yazon, et al |
Yakugaku Zasshi |
Public Health response| Interventions de santé publique |
This descriptive-correlational study investigated the factors influencing the readiness in online teaching and learning
as an alternative delivery mode to continue the teaching-learning process, even the absence of face-to-face interactions between teachers and students. The results revealed that respondent familiarity and capability, preparation, device and access connectivity,
self-efficacy, and experience with technology significantly influence their readiness on the conduct of online teaching and learning modality. It is concluded that faculty and student readiness on online teaching and learning is determined by their competence,
accessibility of ICT tool, preparedness, confidence in their ability to use technology, and exposure to e-learning materials. |
|
|
Capone, V, Caso, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
The aims of this study were to estimate university students' prevalence of mental health during lockdown, and to examine
the associations between mental health and, respectively, academic stress, self-efficacy, satisfaction for degree course, locus of control, COVID-19 risk perception, taking into account the level of information seeking about pandemic. Results showed that 22.3%
of participants were flourishing, and levels of mental well-being appeared in line with normative values in young Italian adults; levels of academic stress were not significantly higher than those found in other student samples before the COVID-19 outbreak.
Students with high levels of information seeking presented higher levels of well-being and risk perception. |
|
|
Caratozzolo, S, Zucchelli, et al |
Aging Clin Exp Res |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study evaluated the impact of COVID-19 on health status in home-dwelling patients with dementia. 848 home-dwelling
outpatients with dementia contacted from April 27 to 30 and evaluated by a semi-structured interview to evaluate possible health complication due to COVID-19 from February 21 to April 30. Patients were 79.7 years old (SD 7.1) and 63.1% were females. Ninety-five
(11.2%) patients developed COVID-19-like symptoms. Non COVID-19 and COVID-19 patients differed for frequency of diabetes (18.5% vs. 37.9%, p < 0.001), COPD (7.3% vs. 18.9%, p < 0.001), and previous flu vaccination (56.7% vs. 37.9%, p < 0.001). Diabetes and
COPD were positively associated with COVID-19, whereas higher dementia severity and flu vaccination showed an inverse association. Among COVID-19 patients, 42 (44.2%) were hospitalized while 32 (33.7%) died. Non COVID-19 patients' hospitalization and mortality
rate were 1.9% and 1.2%, respectively. |
|
|
The Social Divide of Social Distancing: Lockdowns
in Santiago during the COVID-19 Pandemic |
Carranza, Aldo, Goic, et al |
SSRN- Lancet prepublication |
Public health interventions*| Interventions de santé publique |
In this paper we study the impact of shelter-in-place and lockdown interventions in the capital of a developing country,
Santiago, Chile. While high income zones can exhibit reductions in mobility of around 60-80\% (significantly driven by voluntary lockdowns), lower income zones only reduce mobility by 20-40\%. |
|
Early estimation of the risk factors for hospitalization and mortality by COVID-19
in Mexico |
Carrillo-Vega, M, Salinas-Escudero, et al |
PLoS One |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The present study aims to estimate the risk factors for hospitalization and death in the Mexican population infected
by SARS-CoV-2. Using publicly available data , all records of positive SARS-CoV-2 cases were included. Two multiple logistic regression models were fitted to estimate the association between hospitalization and mortality, with other covariables. Data on 10,544
individuals (57.68% men), with mean age 46.47±15.62, were analyzed. Men were about 1.54 times more likely to be hospitalized than women (p<0.001, 95% C.I. 1.37-1.74); individuals aged 50-74 and ≥74 were more likely to be hospitalized than people aged 25-49
(OR 2.05, p<0.001, 95% C.I. 1.81-2.32, and OR 3.84, p<0.001, 95% C.I. 2.90-5.15, respectively). People with hypertension, obesity, and diabetes were more likely to be hospitalized than people without these comorbidities (p<0.01). Men had more risk of death
in comparison to women (OR = 1.53, p<0.001, 95% C.I. 1.30-1.81) and individuals aged 50-74 and ≥75 were more likely to die than people aged 25-49 (OR 1.96, p<0.001, 95% C.I. 1.63-2.34, and OR 3.74, p<0.001, 95% C.I. 2.80-4.98, respectively). Hypertension,
obesity, and diabetes presented in combination conveyed a higher risk of dying in comparison to not having these diseases (OR = 2.10; p<0.001, 95% C.I. 1.50-2.93). Hospitalization, intubation and pneumonia entail a higher risk of dying (OR 5.02, p<0.001, 95%
C.I. 3.88-6.50; OR 4.27, p<0.001, 95% C.I. 3.26-5.59, and OR = 2.57; p<0.001, 95% C.I. 2.11-3.13, respectively). |
|
Methotrexate inhibits SARS-CoV-2 virus replication "in vitro" |
Caruso, A, Caccuri, et al |
J Med Virol |
Therapeutics| Thérapeutique |
By using a systems approach, we identify the host‐encoded pathway, which provides ribonucleotides to viral RNA synthesis,
as a possible target. We show that methotrexate, an FDA‐approved inhibitor of purine biosynthesis, potently inhibits viral RNA replication, viral protein synthesis, and virus release. The effective antiviral methotrexate concentrations are similar to those
used for established human therapies using the same drug. Methotrexate should be most effective in patients at the earliest appearance of symptoms to effectively prevent viral replication, diffusion of the infection, and possibly fatal complications. |
|
Caruso, I, Di Molfetta, et al |
Diabetes Metab Res Rev |
Healthcare Response | Réponse des soins de santé |
AIMS: To assess changes in glucose metrics and their association with psychological distress and lifestyle changes
in patients with type 1 diabetes (T1D) using flash glucose monitoring (FGM) during lockdown following SARS-CoV-2 outbreak. MATERIALS AND METHODS: Single-center, observational, retrospective study enrolling T1D patients who attended a remote visit on April
2020 at the Endocrinology division of the University Hospital Policlinico Consorziale, Bari, Italy. Lockdown-related changes in physical activity level and dietary habits were assessed on a semi-quantitative basis. Changes in general well-being were assessed
by the General Health Questionnaire-12 items (GHQ-12) with a binary scoring system. Glucose metrics were obtained from the Libreview platform for the first two weeks of February 2020 (T0) and the last two weeks before the phone visit (T1). RESULTS: Out of
84 patients assessed for eligibility, 48 had sufficient FGM data to be included in the analysis. FGM data analysis revealed significant reductions in coefficient of variation (CV), number of hypoglycemic events and time below range (TBR), while no changes
were found in time in range (TIR), time above range (TAR), mean sensor glucose (MSG) and glucose management indicator (GMI). Moreover, the frequency of sweets consumption was inversely related to the occurrence of hypoglycemic events during lockdown. |
|
|
Effects of the COVID-19 pandemic on the Brazilian electricity consumption patterns |
Carvalho, M, de Delgado, et al |
International Journal of Energy Research |
Public health interventions*| Interventions de santé publique |
The implementation of mobility restrictions and home office schemes due to the COVID-19 pandemic have influenced electricity
consumption patterns and levels. This study analyzes the effect of physical distancing measures regarding mobility on the energy consumption trends for the Brazilian energy system and its subsystems (Northeast, North, South, and Southeast-Midwest). Trends
were evaluated by the Joinpoint software, and the analysis comprehended the period between January 1 and May 27, 2020. Daily load data was grouped into weeks, with the calculation of weekly percentage changes considering a 95% confidence interval and p < 0.05.
The weekly electricity loads were compared in the periods before and after the isolation decrees were enforced in Brazil (March 15, 2020). Statistically significant decreases were observed in the levels of electricity consumption, with trends represented by
two joinpoints. Due to the different profiles of consumption across the geographic regions, the resulting electricity dynamics were also different. This is the first study to employ joinpoint analysis for the calculation of energy consumption trends focusing
on the COVID-29 pandemic. Data presented herein is unique, in its focus on Brazil, which enables more accurate implications to be drawn for Brazilian policy makers. © 2020 John Wiley & Sons Ltd |
|
Casey, JD, Johnson, et al |
Annals of the American Thoracic Society |
RCT |
This article provides the rationale and background for the ORCHID (Outcomes Related to COVID-19 treated with Hydroxychloroquine
among In-patients with symptomatic Disease) trial which is a multicenter, blinded, randomized trial of hydroxychloroquine versus placebo for the treatment of adults hospitalized with coronavirus disease (COVID-19)trial. This paper also highlights key design
features. |
|
|
Pituitary apoplexy associated with acute COVID-19 infection and pregnancy |
Chan, JL, Gregory, et al |
Pituitary |
Epidemiology| Épidémiologie |
Here we demonstrate the first known case of successful elective induction of vaginal delivery and transsphenoidal intervention
in a near full term gravid patient presenting with pituitary apoplexy and acute SARS-CoV-2 infection. |
|
Charpentier, C, Ichou, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The aim of this study was to assess the analytical performances, sensitivity and specificity, of two rapid tests (Covid-
Presto® test rapid Covid-19 IgG/IgM and NG-Test® IgM-IgG COVID-19) and one automated immunoassay (Abbott SARS-CoV-2 IgG) for detecting anti- SARS-CoV-2 antibodies. Sensitivity of Covid-Presto® test for IgM and IgG was 78.4% and 92.0%, respectively. Sensitivity
of NG-Test® for IgM and IgG was 96.6% and 94.9%, respectively. Sensitivity of Abbott IgG assay was 96.5% showing an excellent agreement with the two rapid tests (κ = 0.947 and κ = 0.936 for NGTest ® and Covid-Presto® test, respectively). An excellent agreement
was also observed between the two rapid tests (κ = 0.937). Specificity for IgM was 100% and 86.5% for Covid-Presto® test and NG-Test®, respectively. Specificity for IgG was 92.0%, 94.9% and 96.5% for Covid-Presto®, NGTest ®, and Abbott, respectively. |
|
|
Chen, G, Su, et al |
Front Med |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical coronavirus
disease 2019 (COVID-19). In this retrospective study, data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20, 2020. All patients were divided
into an exposed group (CHM users) and a control group (non-users). After propensity score matching in a 1:1 ratio, 156 CHM users were matched by propensity score to 156 non-users. No significant differences in seven baseline clinical variables were found between
the two groups of patients. All-cause mortality was reported in 13 CHM users who died and 36 non-users who died. After multivariate adjustment, the mortality risk of CHM users was reduced by 82.2% (odds ratio 0.178, 95% CI 0.076-0.418; P < 0.001) compared
with the non-users. Secondly, age (odds ratio 1.053, 95% CI 1.023-1.084; P < 0.001) and the proportion of severe/critical patients (odds ratio 0.063, 95% CI 0.028-0.143; P < 0.001) were the risk factors of mortality. These results show that the use of CHM
may reduce the mortality of patients with severe/critical COVID-19. |
|
|
Chen, H, Huo, et al |
Sci Total Environ |
Public health interventions*| Interventions de santé publique |
Herein, we present the major chemical composition of non-refractory PM(2.5) (NR-PM(2.5)) and the concentrations of
gaseous pollutants in an urban site in Shanghai before and during the quarantine period of the COVID-19 epidemic. Quarantine measures led to a reduction in the concentrations of PM2.5, SO2, NOx, and CO in Shanghai. Reduction in NOx led to increasing O3 and
decreasing nitrate. |
|
|
PMC7462787; Capped borrower credit risk and insurer hedging during the COVID-19
outbreak |
Chen, S, Yang, et al |
Financ Res Lett |
Economics | Économie |
In this paper, we apply the risk-neutral valuation methodology to evaluate a life insurer's equity. We model the features
capped by the explicit treatment of the borrowing firm's credit risk, the optimal guaranteed rate-setting, and the coronavirus disease (COVID-19) outbreak. The results show that the severe effect of the COVID-19 epidemic on the borrowing firm harms its insurance
business but that stringent capital regulation helps. The severe impact of COVID-19 on both the borrowing firm and the insurer hedging harm policyholder protection, thereby adversely affecting insurance stability. |
|
Chen, T, Li, et al |
J Med Virol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The most common symptoms of illness onset were fever (70, 53.0%), cough (66, 50.0%), and fatigue (58, 43.9%). All patients
were categorized into mild or moderate COVID‐19 type on admission to hospital, and five (3.8%) progress to the severe COVID‐19 type. Sixty six HCWs patients were included in both early and later discharged group. In the logistic analysis, the later discharged
patients had longer time for illness onset to hospital admission (per 1 day; OR: 1.10; 95% CI: 1.03–1.18; P=0.006), higher proportion of >3 onset symptoms clustering (OR: 3.11; 95% CI: 1.27–7.62; P=0.01) and higher percentage of other HCWs (OR: 6.20; 95% CI:
1.49–25.80; P=0.01). HCWs patients were young, female, nurse with less comorbidities, and most were mild or moderate COVID‐19 type. The later discharged patients exhibited characteristics of longer time for illness onset to hospitalization and clustering of
onset symptoms. |
|
|
Chen, X |
IEEE Access |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Theoretical analysis and numerical simulation are employed to conduct prediction of development of the COVID-19 epidemic. |
|
|
Chhetri, A, Chettri, et al |
Journal of Molecular Structure |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The result of the docking of L1-L4 showed a significant inhibitory action against the Main protease (Mpro) of SARS-CoV-2
and the binding energy (ΔG) values of the ligands (L1-L4) against the protein 6LU7 have found to be −7.7 Kcal/mole (L1), −7.0 Kcal/mole (L2), −7.9 Kcal/mole (L3), and −7.9 Kcal/mole (L4).The efficiency of the ligands has been compared with the FDA approved
and clinically trial drugs such as remdesivir, Chloroquin and Hydroxychloroquin and native ligand N3 of main protease 6LU7 to ascertain the inhibitory potential of the studied ligands (L1-L4) against the protein 6LU7. |
|
|
Characterizing Twitter Interaction during COVID-19 pandemic using Complex Networks and Text
Mining |
Chire-Saire, Josimar |
arXiv |
Public Health response| Interventions de santé publique |
The scope of this paper is to analyze the interaction on Twitter of South American countries and characterize the flow
of data through the users using Complex Network representation and Text Mining. The preliminary experiments introduces the idea of existence of patterns, similar to Complex Systems. Besides, the degree distribution confirm the idea of having a System and visualization
of Adjacency Matrices show the presence of users' group publishing and interacting together during the time, there is a possibility of identification of robots sending posts constantly. |
|
Chirico, A, Lucidi, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
Authors investigated the prevalence of physical and sports activities by testing, via a Structural Equation Model,
the influence of such psychosocial variables on the intention to preserve physical fitness during the healthcare emergency.
|
|
|
Knowledge and awareness of covid 19 on the respiratory system-a survey |
Chockalingam, S, Gayatri Devi, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
This study aimed to find the awareness of the amount of impact that the disease COVID-19 had on the respiratory system.
A survey was conducted with a questionnaire of 15 questions using Google Forms given to a study population of college students aged between 18 and 22 years, the link to which was sent to 106 participants. The compiled data were compared with the results of
other studies. There were high similarities in the results of both studies. The research assessed the awareness of COVID-19 and its effect on the respiratory system among college students, and it was found to be high. |
|
Choi, W, Shim, et al |
J Theor Biol |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
We developed a game-theoretic epidemiological model that considers vaccination and social distancing under the assumption
that individuals pursue the maximization of payoffs. By using this model, we identified the individually optimal strategy based on the Nash strategy when both strategies are available and when only one strategy is available. Furthermore, we determined the
relative costs of control strategies at which individuals preferentially adopt vaccination over social distancing (or vice versa). |
|
|
32893789; Seroconversion in Newly Diagnosed Cases of Coronavirus Disease |
Chughtai, OR, Batool, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
All the pre-pandemic samples tested were negative for antibodies with a negative agreement of 100%. Total agreement
at day 7 post-symptom onset was 84%; whereas, it was 94% at day 14 and increased rapidly to 100% at day 21 post-symptom onset. At day 7 post-symptom onset, 68% of patients were seroconverted; and this percentage was 88% and 100% at day 14 and 21 post-symptom
onset, respectively. |
|
Chun, JY, Baek, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie Transmission Clinical data| Données cliniques |
Objectives: The distribution of the transmission onset of COVID-19 relative to the symptom onset is a key parameter
for infection control. It is often not easy to study the transmission onset time, as it is difficult to know who infected whom exactly when. Methods: We inferred transmission onset time from 72 infector-infectee pairs in South Korea, either with known or inferred
contact dates, utilizing the incubation period. Combining this data with known information of the infector's symptom onset, we could generate the transmission onset distribution of COVID-19, using Bayesian methods. Serial interval distribution could be automatically
estimated from our data. Results: We estimated the median transmission onset to be 1.31 days (standard deviation, 2.64 days) after symptom onset with a peak at 0.72 days before symptom onset. The pre-symptomatic transmission proportion was 37% (95% credible
interval CI], 16–52%). The median incubation period was estimated to be 2.87 days (95% CI, 2.33–3.50 days), and the median serial interval to be 3.56 days (95% CI, 2.72–4.44 days). Conclusions: Considering that the transmission onset distribution peaked with
the symptom onset and the pre-symptomatic transmission proportion is substantial, the usual preventive measures might be too late to prevent SARS-CoV-2 transmission. © 2020 The Author(s) |
|
|
Chung, Y, Kim, et al |
Science Editing |
Public Health response| Interventions de santé publique |
This study examined changes in Asian journal editors' daily life and work during the coronavirus disease 2019 (COVID-19)
pandemic and investigated their opinions on expected changes. Fifty-seven respondents (37.5%) felt very or extremely anxious about the COVID-19 pandemic, and 101 (68.4%) reported spending more time on the internet. The workload of editing, reviewing, and
publishing had increased for about one-third of respondents. Of the 68 editors who had received manuscripts on COVID-19, 30 (44.1%) prioritized them. Most respondents (73.7%) predicted that online-only journal publishing would expand after the COVID-19 pandemic. |
|
|
Conley, TE, Probert, et al |
J Crohns Colitis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We conducted a survey on the prevalence of Covid-19 symptoms among consecutive IBD patients treated with biologics
attending our infusion unit for administration of intravenous or subcutaneous biologics during the calendar period 24/02/2020 to 10/07/2020. Of the 203 patients who responded, 105 (52%) had CD and 98 (48%) had UC. Baseline characteristics were comparable between
UC and CD apart from a higher proportion of women among CD patients (84.8% vs 51.1%, PP<0.001) and a higher rate of corticosteroid use among UC patients (12.3% vs 4.8%, p=0.075). Of the entire cohort, 101 (46.6%) patients were on a concomitant immunomodulator.
A large proportion reported following shielding (n=114, 56.2%) or following social isolation (n=40, 19.7%), in keeping with recommendations from UK government. The overall prevalence of typical Covid-19 symptoms was 28.6% among ulcerative colitis (UC) and
13.3% among Crohn’s disease (CD) patients (P=0.009). None of the patients were hospitalized. |
|
|
Connolly, SL, Stolzmann, et al |
Telemed J E Health |
Healthcare Response | Réponse des soins de santé |
A study of the change in the use of telemental health via videoconferencing (TMH-V) due to the pandemic by the Department
of Veterans Affairs. COVID-19 changes in TMH-V appointments were captured during March 11, 2020 - April 22, 2020. Daily TMH-V encounters rose from 1,739 on March 11 to 11,406 on April 22 (556% growth, 222,349 total encounters). Growth was facilitated by preexisting
infrastructure and lessened barriers due to pandemic efforts. |
|
|
The challenges of containing SARS-CoV-2 via test-trace-and-isolate |
Contreras, Sebastian, Dehning, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In our semi-analytical model, we identified two distinct tipping points between controlled and uncontrolled spreading:
one, at which the behavior-driven reproduction number of the hidden infections becomes too large to be compensated by the available test-trace-and-isolate (TTI) capabilities, and one at which the number of new infections starts to exceed the tracing capacity,
causing a self-accelerating spread. We investigated how these tipping points depend on realistic limitations like limited cooperativity, missing contacts, and imperfect isolation, finding that TTI is likely not sufficient to contain the natural spread of SARS-CoV-2.
Therefore, complementary measures like reduced physical contacts and improved hygiene probably remain necessary. |
|
Headache in a group of SARS-COVID-19 patients: an observational prospectical study |
Coppola, A, Tonini, et al |
Neurol Sci |
Clinical data| Données cliniques |
We report the findings of a small group of patients that have been hospitalized in order to better characterize the
specific type of their cephalic pain. We have evaluated 73 patients in total (mean age 69.75). |
|
Correia, M, Constâncio, et al |
Annals of Vascular Surgery |
Healthcare Response | Réponse des soins de santé |
The aim of this article is to understand how the admission of a patient to the ED for vascular surgery changed in this
center in Portugal and if this situation prevented urgent surgical procedures. In the emergency state (ES), 115 patients were observed at the ED and 179 in the 2019 corresponding period. During the ES, patients significantly recurred less to the ED directly
from home (P < 0.001) and were less referred to the ED by primary care doctors (P < 0.001). Patients observed at the ED were significantly more urgent—required urgent surgery or were admitted to the department—than those in 2019 (40% vs. 24%). However, there
were no differences when only considering urgent surgery (14% in ES vs. 10% in 2019). In the ES, 38% of patients observed at the ED were discharged with no follow-up related to vascular surgery against 60% in 2019, although this difference was not significant.
Compared with the preceding 10 years, there are not significant differences in the number of patients who underwent urgent surgery in both ES and non-ES periods. In patients with acute limb ischemia, we did not find an increase in the time between onset of
symptoms and ED admission, during the ES. |
|
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32472897; What Do We Know About COVID-19?: Maxillofacial Surgeons Survey |
Costa, SM, Lacerda, et al |
The Journal of craniofacial surgery |
Healthcare Response | Réponse des soins de santé |
In the present study, the authors performed a nationwide survey with Brazilian oral and maxillofacial surgeons (OMFS)
to evaluate the knowledge of these professionals about the pandemic status of the COVID-19. A total of 142 OMFS replied the survey and the results brings light to an incomparable health public problem that the OMFS in Brazil are no able to protect itself,
diagnose the suspicious and probable cases, request and interpret the correct laboratorial examinations for the treatment of the COVID-19 patients. |
|
Cutri, RM, Mena, et al |
European Journal of Teacher Education |
Public Health response| Interventions de santé publique |
This mixed-methods study was designed to measure and elaborate constructs of faculty online readiness from pre- COVID-19
pandemic literature. Bringing together the validation of a scale to measure these constructs and insights from a focus group, findings suggest that the negative connotations of risk-taking and making mistakes while learning to teach online seem to have been
mitigated by a combination of affective factors such as humility, empathy, and even optimism. Teacher educators explained that transitioning online in a context of a crisis contorts normal longitudinal perceptions of preparation and readiness. This new sense
of temporality was connected to unexpected benefits of bringing them into partnership with their students. However, quantitative and qualitative results are interpreted to show that assessing students’ equitable access to online learning and managing the demands
of scholarship and university-based and academic community service duties are areas in need of attention from professional development designers and policy makers. © 2020 Association for Teacher Education in Europe. |
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Daghmouri, MA, Akremi, et al |
Tunisie Medicale |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
This study aimed to evaluate the availability of personal protective equipment (PPE) in addition to the reality and
perception regarding personal safety in workplace. We carried out a cross-sectional survey from 15th April to 5th May 2020 across public and private institutions in Tunisia. We received 723 responses. We found that there was a likely overuse of PPE in addition
to a high rate of side effects caused by PPE. |
|
|
Dantonello, TM, Kartal-Kaess, et al |
J Pediatr Hematol Oncol |
Clinical data| Données cliniques |
We describe the diagnosis, treatment and outcome of a 4-year-old boy with high-risk acute lymphoblastic leukemia and
COVID-19. Regardless of immunosuppressive induction chemotherapy his symptoms remained moderate. He received only supportive treatment. Seroconversion occurred in a similar period as in immunocompetent adults. Despite prolonged myelosuppression he did neither
acquire secondary infections nor did the treatment delay caused by the infection have a measurable negative impact on the residual disease of acute lymphoblastic leukemia. Intriguingly, residual leukemia even decreased even though he did not receive any antileukemic
therapy. |
|
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Listening to hospital personnel’s narratives during the COVID-19 outbreak |
Daphna-Tekoah, S, Brikman, et al |
International Journal of Environmental Research and Public Health |
Healthcare Response | Réponse des soins de santé |
As a means to address the changing needs of our hospital’s HCWs, we conducted a narrative analysis study in the early
stages of the covid-19 outbreak. A focus group of medical experts, conducted as the initial step, recommended that a bottom-up research tool be used for exploring HCWs’ traumatic experiences and needs. The interviewees expressed a need for physical and psychological
security in the battle against Covid-19, in addition to the need for attachment and meaning. Importantly, we also found that the interview itself may serve as a therapeutic tool. In light of our findings, we recommended changes in hospital practices, which
were subsequently implemented. |
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Telepsychiatry during COVID-19 – A brief survey on attitudes of psychiatrists in
India |
Das, N |
Asian Journal of Psychiatry |
Healthcare Response | Réponse des soins de santé |
We prepared a 25-item semi-structured questionnaire using google form and was circulated among the psychiatrists across
India using Email, WhatsApp, Facebook, LinkedIn and other social media applications via snow-ball sampling technique. The data collection was done from 12th April 2020 to 5th May 2020. This survey provides the much-needed insight about the attitudes of psychiatrists
from a low-resource setting, towards the usage of telepsychiatry in the era of COVID-19. Many young psychiatrists hold a positive attitude towards telepsychiatry, which can be considered as an optimistic sign for the future. |
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The Contagion Externality of a Superspreading Event: The Sturgis Motorcycle Rally and COVID-19 |
Dave, Dhaval, Friedson, et al |
SSRN- Lancet prepublication |
Epidemiology| Épidémiologie Public Health response| Interventions de santé publique
Economics | Économie |
Between August 7 and August 16, 2020, nearly 500,000 motorcycle enthusiasts converged on Sturgis, South Dakota for
its annual motorcycle rally. This study is the first to explore the impact of this event on social distancing and the spread of COVID-19. First, using anonymized cell phone data we document that smartphone pings from non-residents, and foot traffic at local
establishments each rose substantially in the census block groups hosting Sturgis rally events. We show that a month following the onset of the Rally, COVID-19 cases increased by approximately 6 to 7 cases per 1,000 population in its home county of Meade.
Estimates show that following the event, counties that contributed the highest inflows of rally attendees experienced a 7.0 to 12.5% increase in COVID-19 cases relative to counties that did not contribute inflows. Descriptive evidence suggests these effects
may be muted in states with stricter mitigation policies (i.e., restrictions on bar/restaurant openings, mask-wearing mandates). We conclude that the Sturgis Motorcycle Rally generated public health costs of as much as $12.2 billion. |
|
Debnath, R, Bardhan, et al |
PLoS One |
Public Health Priorities| Priorités de santé publique |
This study investigated how Indian government formed reactive policies to fight coronavirus across its policy sectors.
Primary data was collected from the Press Information Bureau (PIB) in the form press releases of government plans, policies, programme initiatives and achievements. A text corpus of 260,852 words was created from 396 documents from the PIB. An unsupervised
machine-based topic modelling using Latent Dirichlet Allocation (LDA) algorithm was performed on the text corpus. It was done to extract high probability topics in the policy sectors. The interpretation of the extracted topics was made through a nudge theoretic
lens to derive the critical policy heuristics of the government. Results showed that most interventions were targeted to generate endogenous nudge by using external triggers. Notably, the nudges from the Prime Minister of India was critical in creating herd
effect on lockdown and social distancing norms across the nation. A similar effect was also observed around the public health (e.g., masks in public spaces; Yoga and Ayurveda for immunity), transport (e.g., old trains converted to isolation wards), micro,
small and medium enterprises (e.g., rapid production of PPE and masks), science and technology sector (e.g., diagnostic kits, robots and nano-technology), home affairs (e.g., surveillance and lockdown), urban (e.g. drones, GIS-tools) and education (e.g., online
learning). |
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Deepa Viswasini, R, Abilasha, et al |
International Journal of Research in Pharmaceutical Sciences |
Healthcare Response | Réponse des soins de santé |
The study aims at assessing the general awareness about Covid-19 and knowledge about the role of Convalescent plasma
therapy for treatment of Covid-19 among post graduate dental students. A total of 103 participant were included in the study. The knowledge regarding covid-19 and the awareness about the usefulness of convalescent plasma was variable. Around 90% of the participants
were aware of the effectiveness of convalescent plasma therapy. Advance training, proper PPE and training on handling the patients with any infectious disease should be dealt with in detail for reducing the spread from dental clinics and dentists. |
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|
Women’s and men’s work, housework and childcare, before and during COVID-19 |
Del Boca, D, Oggero, et al |
Review of Economics of the Household |
Public Health response| Interventions de santé publique |
Using new survey data collected in April 2020 from a representative sample of Italian women, we analyse the effects
of working arrangements due to COVID-19 on housework, childcare and home schooling among couples where both partners work. Our results show that most of the additional housework and childcare associated to COVID-19 falls on women while childcare activities
are more equally shared within the couple than housework activities. Analysis of work–life balance satisfaction shows that working women with children aged 0–5 are those who find balancing work and family more difficult during COVID-19. |
|
Demeester, S, Demuyser, et al |
Int J Lab Hematol |
Clinical data| Données cliniques |
In this letter to the editor authors discuss using a prospective, single‐centre study in Belgium is to describe the
course of multiple haematological parameters during hospitalization of COVID‐19 patients and to investigate differences according to outcome. |
|
|
Dharsandiya, M, Shah, et al |
Indian journal of medical microbiology |
Clinical data| Données cliniques |
SARS-CoV-2 predominantly involves the lungs producing acute lung injury, but it can also give rise to a variety of
complications involving the central nervous system, gastrointestinal system, kidney and also viral sepsis. With this case report, we are discussing unusual series of complication from acute lung injury, followed by viral sepsis then encephalitis, followed
by progressive macrophage activation syndrome. |
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|
Maternal and Perinatal Outcomes of Pregnant Women with
SARS-COV-2 infection |
Di Mascio, D |
Ultrasound Obstet Gynecol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
OBJECTIVES: To evaluate maternal and perinatal outcomes of pregnant women affected by SARS-COV-2. METHODS: This was
a multinational retrospective cohort study including women with laboratory-confirmed SARS-COV-2 from 73 centers from 22 different countries in Europe, United States, South America, Asia and Australia from February 1, 2020 to April 30, 2020. Confirmed SARS-COV-2
infection was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity including admission
to intensive care unit (ICU), use of mechanical ventilation, or death. RESULTS: 388 singleton pregnancies tested positive to SARS-COV-2 at RT-PCR nasal and pharyngeal swab were included in the study. The primary outcome was observed in 47/388 women (12.1%).
43/388 women (11.1%) were admitted to ICU, 36/388 (9.3%) required mechanical ventilation, and 3/388 women deceased (0.8%). Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of the study. Among the other 266 women, 6 had spontaneous
first-trimester abortion, 3 had elective termination of pregnancy, 6 had stillbirth, and 251 delivered a live-born infant. The rate of preterm birth less than 37 weeks of gestation was 26.3% (70/266). Of the 251 live-born infants, 69/251 (27.5%) were admitted
to NICU, with 5 neonatal deaths (2.0%). The overall rate of perinatal death was 4.1% (11/266). Only one infant (1/251, 0.4%) born from a mother tested positive during the third trimester, was found positive to SARS-COV-2 at RT-PCR. CONCLUSIONS: SARS-COV-2
in pregnant women is associated with 0.8% rate of maternal mortality, but 11.1% rate of admission to ICU. The risk of vertical transmission seems to be negligible. This article is protected by copyright. All rights reserved. |
|
Diociaiuti, A, Giancristoforo, et al |
J Eur Acad Dermatol Venereol |
Clinical data| Données cliniques Immunology | Immunologie |
We recently described 19 adolescents with chilblain‐like lesions who were negative for SARS‐CoV‐2 by RT‐PCR and IgG
serology for nucleocapsid protein |
|
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Closed Facebook groups and COVID-19: an evaluation of utilization prior to and
during the pandemic |
Docimo, S, J, et al |
Surg Endosc |
Healthcare Response | Réponse des soins de santé |
We aim to evaluate the use of Online Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) closed Facebook
groups, during and prior to the COVID-19 pandemic. The COVID-19 pandemic halted surgical education at all levels. The membership and utilization of closed Facebook groups increased significantly in many instances, demonstrating the importance of internet-based
surgical education now and into the future. |
|
Dodd, RY, Xu, et al |
Jama |
Public Health response| Interventions de santé publique |
We examined whether testing of donations for SARS-CoV-2 antibodies was associated with changes in donor characteristics
and reactivity of donated blood. In the 2 weeks prior to initiation of testing, 11% of donors were first-time donors compared with 17% (P < .001) after that time. Reactive rates increased over the study period, from 1.18% (95% CI, 1.11%-1.25%) to 2.58% (95%
CI, 2.48%-2.69%; P < .001). This study found that, after the introduction of antibody testing, the proportion of first-time donors increased, and donations from younger and racial and ethnic minority donors were more likely to be reactive. |
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|
Dong, X, Sun, et al |
International Journal of Medical Sciences |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In this study, we aimed to evaluate the association of LDH with in-hospital mortality in severe and critically ill
patients with COVID-19. This single-center retrospective study enrolled 119 patients. Compared to the survival group, LDH levels in the dead group were significantly higher 559.5 (172, 7575) U/L vs 228 (117, 490) U/L, (P < 0.001)]. In Multivariate Cox regression,
it remained an independent risk factor for in-hospital mortality (Hazard ratio 5.985, 95.0% CI: 1.498-23.905; P=0.011). A cutoff value of 353.5 U/L predicted the in-hospital mortality with a sensitivity of 94.4% and a specificity of 89.2% respectively. |
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|
Dos Anjos, JLM, Santos Junior, et al |
Revista Pesquisa em Fisioterapia |
Clinical data| Données cliniques |
This case report describes using the prone position (PP) in a patient with spontaneous ventilation with mild respiratory
failure secondary to COVID-19. The prone position such patients is safe and can be used as adjunctive therapy to treatment. |
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Maximum entropy approach to reliability analysis based epidemic disease model |
Du, YM, Sun, et al |
Kexue Tongbao/Chinese Science Bulletin |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This study analyzes the dynamic model of epidemic disease system based on the maximum entropy approach to reliability.
Additionally, limited immunity duration model is also considered. The relationship between the infectious ratio of steady state and the proportion of immunization duration to healing period is presented. |
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30-day mortality for fractured neck of femur patients with concurrent COVID-19
infection |
Dupley, L, Oputa, et al |
European Journal of Orthopaedic Surgery and Traumatology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Introduction: Risk factors for mortality associated with COVID-19 have been reported to include increased age, male
sex and certain comorbidities. Fracture neck of femur (NOF) patients is high-risk surgical patients, often with multiple comorbidities and advanced age. We quantify the 30-day mortality rate in fractured NOF patients with a positive peri-operative COVID-19
antigen test and identify risk factors for increased mortality. Methods: This is a retrospective multi-centre review of all patients admitted with a fractured NOF and a confirmed laboratory diagnosis of COVID-19 between 1 March and 26 April 2020. Demographic
data, comorbidities, ASA grade and date of death (if applicable) were collected. Results: There were 64 patients in the cohort with an overall 30-day mortality rate of 32.8% (n = 21). Thirty-five (55%) were female, and mean age was 83 (SD 9, range 46–100)
years. There was significantly increased mortality for those with a history of myocardial infarction (p = 0.03). Sixty-four percent of patients underwent surgery within the 36-h target, which is comparable to previous data for the same time of year. Overall
mortality increased to 50% (n = 32) at 45 days post-operatively. Conclusion: This is a large review of 30-day mortality in NOF patients with concurrent COVID-19 infection. We report a substantial increase from the pre-COVID-19 mean 30-day mortality rate (6.5%
in 2019). We highlight the need for counselling patients when presenting with a NOF in relation to peri-operative COVID-19 infection and the associated increased risks. © 2020, Springer-Verlag France SAS, part of Springer Nature. |
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Dutta, V, Dubey, et al |
Sci Total Environ |
Public health interventions*| Interventions de santé publique |
This study described signs of rejuvenation and significant improvement on many parameters in the Ganga River, following
nationwide lockdown due to coronavirus pandemic. This paper analyses historical data on water quality and compares with quality observed during the lockdown period. The notable level of improvement in water quality was due to the absence of industrial pollutants
and reduction in the amount of solid waste that spanned for eight weeks. |
|
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Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2 |
Edwards, MJ, Becker, et al |
J Biol Chem |
Therapeutics| Thérapeutique |
we analyzed whether sphingosine regulates the infection of cultured and freshly isolated ex vivohuman epithelial cells
with pseudoviral particles expressing SARS-CoV-2 spike (pp-VSV-SARS-CoV-2 spike) that served as a bona fide system mimicking SARS-CoV-2 infection. We demonstrate that exogenously applied sphingosine suspended in 0.9% NaCl prevents cellular infection with pp-SARS-CoV-2
spike. Pre-treatment of cultured Vero epithelial cells or freshly isolated human nasal epithelial cells with low concentrations of sphingosine prevented adhesion of and infection with pp-VSV-SARS-CoV-2 spike. Mechanistically, we demonstrate that sphingosine
binds to ACE2, the cellular receptor of SARS-CoV-2, and prevents the interaction of the receptor binding domain of the viral spike protein with ACE2. These data indicate that sphingosine prevents at least some viral infections by interfering with the interaction
of the virus with its receptor. Our data also suggest that further preclinical and finally clinical examination of sphingosine is warranted for potential use as a prophylactic or early treatment for coronavirus disease-19. |
|
Hydroxychloroquine and azithromycin as a treatment of COVID-19: Electrocardiogram
variability |
El Ouarradi, A, Abdeladim, et al |
Journal of the Saudi Heart Association |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The aim of this study is to describe the cardiovascular effect of hydroxychloroquine and azithromycin by analyzing
surface ECG in patients with COVID 19. QT prolongation is a real risk with the combination of HCQ and azithromycin. In the current context, it is necessary to select patients at high risk of severe rhythm disturbances that require closer ECG monitoring. |
|
Loss of smell in COVID-19 patients: MRI data reveals a transient edema of the
olfactory clefts |
Eliezer, M, Hamel, et al |
Neurology |
Clinical data| Données cliniques |
To assess the physiopathology of olfactory function loss (OFL) in COVID-19 patients, we evaluated the olfactory clefts
on MRI during the early stage of the disease and one month later. At the early stage, SARS-CoV2-infected patients had a mean olfactory score of 2.8 +/- 2.7 (range 0–8), and MRI displayed a complete obstruction of the OC in 19 out of 20 patients. At one month
follow-up, the olfactory score had improved to 8.3 +/- 1.9 (range 4–10) in patients, and only 7 out of 20 patients still had an obstruction of the OC. |
|
Descriptive Epidemiology of Coronavirus Disease 2019 in Nigeria, 27 February-6 June,
2020 |
Elimian, KO, Ochu, et al |
Epidemiol Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The objective of this study was to describe the epidemiology of COVID-19 in Nigeria with a view of generating evidence
to enhance planning and response strategies. A national surveillance dataset between 27 February and 6 June, 2020 was retrospectively analysed, with confirmatory testing for COVID-19 done by real-time polymerase chain reaction (RT-PCR). The primary outcomes
were cumulative incidence (CI) and case fatality (CF). A total of 40926 persons (67% of total 60839) had complete records of RT-PCR test across 35 States and the Federal Capital Territory, 12289 (30·0%) of whom were confirmed COVID-19 cases. Of those confirmed
cases, 3467 (28.2%) had complete records of clinical outcome (alive or dead), 342 (9.9%) of which died. The overall CI and CF were 5·6 per 100000 population and 2·8%, respectively. The highest proportion of COVID-19 cases and deaths were recorded in persons
aged 31-40 years (25·5%) and 61-70 years (26·6%), respectively; and males |
|
Emara, MH, Mazid, et al |
Medical hypotheses |
Clinical data| Données cliniques |
We hereby present the data of 3 patients presented to our OPD and were admitted as diabetic ketoacidosis (DKA) and
2–3 days later they developed manifestations suggestive of COVID-19 and proved by swabbing as positive cases. |
|
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Computational insight of dexamethasone against potential targets of SARS-CoV-2 |
Fadaka, AO, Sibuyi, et al |
J Biomol Struct Dyn |
Therapeutics| Thérapeutique |
Repurposed anti-viral drugs have played a huge role in combating the virus, and most recently, dexamethasone (Dex)
have shown its therapeutic activity in severe cases of COVID-19 patients. The study sought to provide insights on the anti-COVID-19 mechanism of Dex at both atomic and molecular level against SARS-CoV-2 targets. Computational methods were employed to predict
the binding affinity of Dex to SARS-CoV-2 using the Schrodinger suite (v2020-2). The selected targets were SARS-CoV-2 main protease (Mpro), and host secreted molecules glucocorticoid receptor, and Interleukin-6 (IL-6). Dex showed stronger affinity to its
theoretical (glucocorticoid) receptor with a superior docking score of −14.7 and a good binding energy value of −147.48 kcal/mol; while short hydrogen bond distances were observed in both Mpro and IL-6 when compared to glucocorticoid receptor. This study demonstrates
that Dex could bind to both the viral and host receptors as a potential drug candidate for COVID-19. |
|
Falasca, L, Nardacci, et al |
J Infect Dis |
Clinical data| Données cliniques |
We performed autopsies on 22 patients with COVID-19 (18 with co-morbidities and 4 without co-morbidities) who died
at the National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS Hospital, Rome, Italy. Tissues from the lung, heart, liver, kidney, spleen and bone marrow (but not the brain) were examined. Findings show COVID-19 causes multisystem pathology. Pulmonary
and cardiovascular involvement are dominant pathological features. Extra-pulmonary manifestations include hepatic, kidney, splenic and bone marrow involvement, and microvascular injury and thrombosis were also detected. These findings were similar in patients
with or without pre-existing medical co-morbidities. |
|
|
Dynamic analysis of the mathematical model of COVID-19 with demographic effects |
Faraz, N, Khan, et al |
Z Naturforsch C J Biosci |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
In this article, we present an extended and modified form of SIR and SEIR model, respectively. We begin by investigating
a simple mathematical model that describes the pandemic. Then we apply different safety measures to control the pandemic situation. The mathematical model with and without control is solved by using homotopy perturbation method. Obtained solutions have been
presented graphically. Finally, we develop another mathematical model, including quarantine and hospitalization. |
|
Featherstone, Leo, Di Giallonardo, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Using simulations, we demonstrate that birth-death phylodynamic models can employ occurrence data to eliminate bias
in estimates of the basic reproductive number due to misspecification of the sampling process. In contrast, the coalescent exponential model is robust to such sampling biases, but in the absence of a sampling model it cannot exploit occurrence data. Subsequent
analysis of the SARS-CoV-2 epidemic in the northwest USA supports these results. We conclude that occurrence data are a valuable source of information in combination with birth-death models. These data should be used to bolster phylodynamic analyses of infectious
diseases and other rapidly spreading species in the future. |
|
|
Fisher, KA, Tenforde, et al |
MMWR Morb Mortal Wkly Rep |
Epidemiology| Épidémiologie Transmission Public Health response| Interventions de santé
publique |
Findings from a case-control investigation of symptomatic outpatients from 11 U.S. health care facilities found that
close contact with persons with known COVID-19 or going to locations that offer on-site eating and drinking options were associated with COVID-19 positivity. Adults with positive SARS-CoV-2 test results were approximately twice as likely to have reported dining
at a restaurant than were those with negative SARS-CoV-2 test results. |
|
|
32884676; Online dashboard and data analysis approach for assessing COVID-19
case and death data |
Florez, H, Singh, et al |
F1000Research |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
In this work, we have designed and developed an online dashboard that presents actual information about COVID-19. Furthermore,
based on this information, we have designed a mathematical model in order to make projections about the evolution of cases and deaths worldwide and by country. |
|
Frank, TD |
Journal of Biological Systems |
Epidemiology| Épidémiologie |
COVID-19 order parameters and their time constants are derived within a standard SEIR dynamical systems framework and
determined explicitly for two published studies on COVID-19 trajectories in Italy and China. The results suggest the existence of certain relationships between order parameters, time constants, and reproduction ratios. However, the examples from Italy and
China also suggest that COVID-19 order parameters and time constants in general depend on regional differences and the stage of the local COVID-19 epidemic under consideration. |
|
|
Franza, F, Basta, et al |
Psychiatria Danubina |
Healthcare Response | Réponse des soins de santé |
In our study, we have evaluated stress levels in 102 healthcare workers recruited in different rehabilitation departments
(psychiatric and multidisciplinary). In particular, we evaluated the fatigue of compassion, vicarious trauma, burnout and hope (hopelessness) in the first two months of lookdown due to the COVID-19. The results obtained after the administration of the following
evaluation scales: sCFs, CBI, Pro QOL, HBS, showed an overall increase in the scores in all professional figures. Significant compassion fatigue and burnout percentage is present in several groups. The highest levels of hopelessness in some professional figures,
while higher educational levels can protect workers from the risk of developing high levels of work stress. |
|
|
Follow-up ct results of covid-19 patients with initial negative chest ct |
Fu, B, Hu, et al |
Infection and Drug Resistance |
Clinical data| Données cliniques |
The aim of this study was to determine whether new pulmonary lesions will develop in COVID-19 patients with negative
initial chest CT findings and to investigate their CT features and outcome during treatment. In COVID-19 patients with negative initial chest CT findings, new pulmonary lesions may develop during treatment. |
|
Funari, R, Chu, et al |
Biosensors and Bioelectronics |
Coronavirology| Coronavirologie |
In this work, based on the principle of localized surface plasmon resonance (LSPR), we develop an opto-microfluidic
sensing platform with gold nanospikes, fabricated by electrodeposition, to detect the presence and amount of antibodies specific to the SARS-CoV-2 spike protein in 1μL of human plasma diluted in 1mL of buffer solution, within
∼30min. The target antibody concentration can be correlated
with the LSPR wavelength peak shift of gold nanospikes caused by the local refractive index change due to the antigen–antibody binding. This label-free microfluidic platform achieves a limit of detection of
∼0.08ng/mL (∼0.5pM),
falling under the clinical relevant concentration range. We demonstrate that our opto-microfluidic platform offers a promising point-of-care testing tool to complement standard serological assays and make SARS-CoV-2 quantitative diagnostics easier, cheaper,
and faster. |
|
|
Fuwape, IA, Okpalaonwuka, et al |
Air Quality, Atmosphere and Health |
Public health interventions*| Interventions de santé publique |
This study investigated the impact of the lockdown on air pollution in three highly populated and industrious cities
in Nigeria. Compared with historical mean values, NO2 levels increased marginally by 0.3% and 12% in Lagos and Kaduna respectively. However, the city of Port Harcourt saw a decrease of 1.1% and 215.5% in NO2 and SO2 levels respectively. Elevated levels of
O3 were observed during the period of lockdown. Results suggest that there are other sources of air pollution apart from transportation and industrial sources. Findings showed that the COVID-19-induced lockdown was responsible for a decrease in NO2 levels
in two of the locations studied. |
|
|
Gao, G, Wang, et al |
J Acquir Immune Defic Syndr |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
We conducted a retrospective study to summarize the clinical practices of nonsevere patients with COVID-19 receiving
the standard care, LPV/r or chloroquine in Beijing Ditan Hospital from January 20 to March 26, 2020. Of the 129 patients included in the study, 59 received the standard care, 51 received LPV/r, and 19 received chloroquine. The demographics and baseline characteristics
were comparable among the 3 groups. The median duration of fever, median time from symptom onset to chest computer tomography improvement, and negative conversion of the nucleic acid were similar among the 3 groups. The median increase in cycle threshold values
of N and ORF1ab gene for patients receiving LPV/r or chloroquine or the standard care during the treatment course was 7.0 and 8.5, 8.0, and 7.6, 5.0, and 4.0, respectively. These figures were not found significantly different among the 3 groups. |
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Understanding COVID-19 dispersion in the filipino sociocultural context |
Garcia, LL, Castillo, et al |
Asia Pacific Journal of Health Management |
Epidemiology| Épidémiologie |
This study aims to discover the sociocultural factors affecting the disease dispersion pattern of the COVID-19 in the
Philippines. This is an ecological study where the unit of observation is the cases of COVID-19 in the country. The cases compared was defined in various ways to create an explanation of the dispersion pattern of COVID-19 in the country. Data was taken from
the official reports of the Philippine Department of Health as of March 13, 2020, on the 52 confirmed cases of COVID-19 in the country. Data gathered from the reports were age, sex, existing diseases, acquisition (local or international), proximity to carrier
and health status. Results revealed that older male Filipinos are at higher risk of acquiring COVID-19 with prognosis defined by certain culturally-related diseases. The dispersion of the disease in the country is further compounded by the sociocultural context
the Filipinos are in. |
|
Garcia-Vidal, C, Sanjuan, et al |
Clinical Microbiology and Infection |
Clinical data| Données cliniques |
An observational cohort study of all consecutive patients admitted for ≥48 hours to the Hospital Clinic of Barcelona
for COVID-19 (28 February to 22 April 2020) who were discharged or dead. Community-acquired co-infection at COVID-19 diagnosis was uncommon (31/989, 3.1%) and mainly caused by Streptococcus pneumoniae and Staphylococcus aureus. A total of 51 hospital-acquired
bacterial superinfections, mostly caused by Pseudomonas aeruginosa and Escherichia coli, were diagnosed in 43 patients (4.7%), with a mean (SD) time from hospital admission to superinfection diagnosis of 10.6 (6.6) days. Overall mortality was 9.8% (97/989). |
|
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Cancer care in a Western Indian tertiary center during the pandemic: Surgeon's perspective |
Gautam, P, Gandhi, et al |
J Surg Oncol |
Healthcare Response | Réponse des soins de santé |
An anonymous structured questionnaire was constructed and e-mailed to all surgical oncologists working at our institute
.Of the 118 patients having an operation, 18 had complications. When the staff of the main operating theater tested COVID positive, the complex was shut down. However surgical oncology work continued at an affiliated institute about 10 km away from the main
hospital. |
|
Ge, H, Pan, et al |
Frontiers in Medicine |
Clinical data| Données cliniques |
Background: Lung mechanics during invasive mechanical ventilation (IMV) for both prognostic and therapeutic implications;
however, the full trajectory lung mechanics has never been described for novel coronavirus disease 2019 (COVID-19) patients requiring IMV. The study aimed to describe the full trajectory of lung mechanics of mechanically ventilated COVID-19 patients. The clinical
and ventilator setting that can influence patient-ventilator asynchrony (PVA) and compliance were explored. Post-extubation spirometry test was performed to assess the pulmonary function after COVID-19 induced ARDS. Methods: This was a retrospective study
conducted in a tertiary care hospital. All patients with IMV due to COVID-19 induced ARDS were included. High-granularity ventilator waveforms were analyzed with deep learning algorithm to obtain PVAs. Asynchrony index (AI) was calculated as the number of
asynchronous events divided by the number of ventilator cycles and wasted efforts. Mortality was recorded as the vital status on hospital discharge. Results: A total of 3,923,450 respiratory cycles in 2,778 h were analyzed (average: 24 cycles/min) for seven
patients. Higher plateau pressure (Coefficient: −0.90; 95% CI: −1.02 to −0.78) and neuromuscular blockades (Coefficient: −6.54; 95% CI: −9.92 to −3.16) were associated with lower AI. Survivors showed increasing compliance over time, whereas non-survivors showed
persistently low compliance. Recruitment maneuver was not able to improve lung compliance. Patients were on supine position in 1,422 h (51%), followed by prone positioning (499 h, 18%), left positioning (453 h, 16%), and right positioning (404 h, 15%). As
compared with supine positioning, prone positioning was associated with 2.31 ml/cmH2O (95% CI: 1.75 to 2.86; p < 0.001) increase in lung compliance. Spirometry tests showed that pulmonary functions were reduced to one third of the predicted values after extubation.
Conclusions: The study for the first time described full trajectory of lung mechanics of patients with COVID-19. The result showed that prone positioning was associated with improved compliance; higher plateau pressure and use of neuromuscular blockades were
associated with lower risk of AI. © Copyright © 2020 Ge, Pan, Zhou, Xu, Zhang, Zhang, Yi, Yang, Zhou, Liu and Zhang. |
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Impact of the COVID-19 outbreak on air pollution levels in East Asia |
Ghahremanloo, M, Lops, et al |
Science of the Total Environment |
Public health interventions*| Interventions de santé publique |
This study leverages satellite remote sensing to investigate the impact of the coronavirus outbreak and the resulting
lockdown of public venues on air pollution levels in East Asia. NO2 experienced the highest decrease in East Asia due to lockdowns. NO2 and SO2 decreased more than HCHO and CO in Wuhan. SO2 increased in Seoul and Tokyo due to polluted air transport in 2020. |
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Data-driven Simulation and Optimization for Covid-19 Exit Strategies |
Ghamizi, S, Rwemalika, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
This study built a pandemic simulation and forecasting toolkit that combines a deep learning estimation of the epidemiological
parameters of the disease in order to predict the cases and deaths, and a genetic algorithm component searching for optimal trade-offs/policies between constraints and objectives set by decision-makers. Replaying pandemic evolution in various countries, we
experimentally show that our approach yields predictions with much lower error rates than pure epidemiological models in 75% of the cases and achieves a 95% R2 score when the learning is transferred and tested on unseen countries. When used for forecasting,
this approach provides actionable insights into the impact of individual measures and strategies. |
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Variety of radiological findings in a family with COVID-19: a case report |
Gharekhanloo, F, Sedighi, et al |
Egyptian Journal of Radiology and Nuclear Medicine |
Clinical data| Données cliniques |
Case report of 2 sisters with COVID-19 who had close contact with their 77 year old grandmother. |
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PMC7480337; Study of COVID-19 pandemic in London (UK) from urban context |
Ghosh, A, Nundy, et al |
Cities |
Epidemiology| Épidémiologie Transmission |
This study presents an investigation of the COVID-19 transmission from the urban context. |
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Autonomic dysfunction heralding acute motor axonal neuropathy in COVID-19 |
Ghosh, R, Roy, et al |
J Neurovirol |
Clinical data| Données cliniques |
We present a case report of a 20-year-old patient who developed acute onset dysautonomia heralding AMAN during SARS-CoV-2
infection. |
|
Gil-Moles, M, Basu, et al |
Chemistry |
Therapeutics| Thérapeutique |
Here we evaluated the lead compound Auranofin and five selected gold organometallics as inhibitors of two relevant
drug targets of severe acute respiratory syndrome coronaviruses (SARS-CoV). The gold metallodrugs were effective inhibitors of the interaction of the SARS-CoV-2 spike protein with the angiotensin converting enzyme 2 (ACE2) host receptor and might thus interfere
with the viral entry process. The gold metallodrugs were also efficient inhibitors of the papain-like protease (PLpro) of SARS-CoV-1 and SARS-CoV-2, which is a key enzyme in the viral replication. Regarding PLpro from SARS-CoV-2, the here reported inhibitors
are among the very first experimentally confirmed examples with activity against this target enzyme. Importantly, the activity of the complexes against both PLpro enzymes correlated with the ability of the inhibitors to remove zinc ions from the labile zinc
center of the enzyme. Taken together, the results of this pilot study suggest further evaluation of gold complexes as SARS-CoV antiviral drugs. |
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The COVID-19 Pandemic, Authoritarianism, and Rejection of Sexual Dissenters in Poland |
Golec de Zavala, A, Bierwiaczonek, et al |
Psychology of Sexual Orientation and Gender Diversity |
Public Health response| Interventions de santé publique |
In Poland, both, gender hierarchy restricting women's sexuality and heteronormativity are rooted in traditional "family
values" supported by the teachings of the Polish Catholic Church and attached to Polish national identity. Dissenters to traditional norms regulating gender and sexual relations are rejected as a threat to social order and national unity. Latent growth curve
modeling performed on data from a 3-wave longitudinal study indicated linear, interrelated increases in authoritarianism; a desire for national cohesion; and rejection of sexual dissenters in the nationally representative sample of Polish participants (N =
889) as the novel coronavirus (COVID-19) pandemic unfolded in Poland. Data were collected before and during the outbreak of the pandemic allowing us to link the changes in social attitudes to this naturally occurring threat. Cross-lagged panel analysis indicated
that authoritarianism predicted desire for national cohesion, which resulted in rejection of dissenters. These results are in line with theoretical models of authoritarianism as a response to threat. They are also in line with findings linking death anxiety
and the threat of infectious disease to increases in authoritarianism, traditional worldview defense, in-group cohesion and sexual restrictiveness. © 2020 American Psychological Association. |
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Gomes, DS, Andrade, et al |
Epidemiology and infection |
Epidemiology| Épidémiologie |
This study aimed to analyse the trend and spatial-temporal clusters of risk of transmission of COVID-19 in northeastern
Brazil. We conducted an ecological study using spatial and temporal trend analysis. All confirmed cases of COVID-19 in the Northeast region of Brazil were included, from 7 March to 22 May 2020. There were 113 951 confirmed cases of COVID-19. The average incidence
rate was 199.73 cases/100 000 inhabitants. We observed an increasing trend in the incidence rate in all states. Spatial autocorrelation was reported in metropolitan areas, and 178 municipalities were considered a priority, especially in the states of Ceará
and Maranhão. We identified 11 spatiotemporal clusters of COVID-19 cases; the primary cluster included 70 municipalities from Ceará state. COVID-19 epidemic is increasing rapidly throughout the Northeast region of Brazil, with dispersion towards countryside. |
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Gonzales-Zamora, J, Quiroz, et al |
Medwave |
Clinical data| Données cliniques |
We present the case of a 48-year-old man with no past medical history who presented to the hospital with dyspnea, cough,
subjective fever, and diarrhea for 10 days. Nasopharyngeal PCR was positive for SARS-CoV-2. His respiratory status rapidly worsened to the point of requiring supplemental oxygen by high flow nasal cannula with FiO2 of 80%. Our case illustrates the role of
Remdesivir for the treatment of severe COVID-19 pneumonia. We also observed a possible clinical benefit of corticosteroids in the context of suspected cytokine storm. |
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Evolution and early government responses to COVID-19 in South America |
González-Bustamante, B |
World Development |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This article analyses the evolution of COVID-19 and early government responses to the pandemic in eight South American
countries. To this aim, this study explores indicators which trace the progression of the pandemic and analyses factors related of state capacity which impacted on the early response of governments of implementing restrictive policies of social distancing
associated with a suppression strategy. The results indicate that fiscal expenditure on health, regional and local government capacity, and pressure on the health system accelerate government response with stringent interventions. A counter-intuitive finding
is that the economic strength of a country delays these types of reactions. The effect of these interventions is something that should be studied in greater depth, considering, for example, sociocultural factors. Lastly, only cases such as Uruguay and Paraguay
show some signs of having the pandemic relatively under control by mid-May, while Brazil and Peru face very adverse scenarios. |
|
Graffigna, G, Barello, et al |
PLoS One |
Public Health response| Interventions de santé publique |
The study investigated the role of health engagement in predicting citizens' compliance with health emergency containment
measures. An online survey was administered between February 28 and March 4, 2020 on a representative sample of 1000 Italians. The questionnaire included a measure of health engagement (Patient Health Engagement Scale), resulting in positions that describe
the psychological readiness to be active in one's own health management, and a series of ad hoc items intended to measure citizens' perceived susceptibility and severity of the disease, orientation towards health management, trust in institutional bodies,
health habits and food consumption.Less engaged people show higher levels of perceived susceptibility to the virus and severity of the disease; they are less trustful of scientific and healthcare authorities, they feel less self-effective in managing their
own health-both in normal conditions and under stress-and are less prone to cooperate with healthcare professionals. Low levels of health engagement also are associated with a change in the usual purchase behavior. |
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|
Graziani, A, Domenicali, et al |
Pulmonology |
Clinical data| Données cliniques |
We evaluated 138 patients with COVID 19 admitted to our Institution between March 2020 and May 2020. All patients were
COVID 19 positive according to clinical diagnostic criteria reverse-transcription–polymerase chain-reaction (RT-PCR) and Chest Thoracic tomography. On admission, most of them were haemodynamically stable (78%) and febrile (87%). During hospitalization, some
developed progressive respiratory failure and received oxygen supplementation (41%). Four of them were started on Continuous Positive Airways Pressure (CPAP) but two died because of worsening Respiratory Failure. |
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PMC7446990; Descriptive Analysis of Patients Living With HIV Affected by COVID-19 |
Gudipati, S, Brar, et al |
J Acquir Immune Defic Syndr |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This is a case series that included 14 patients living with HIV (PLWH) with laboratory-confirmed COVID-19 infection
who were evaluated at Henry Ford Hospital in Detroit, Michigan, between March 20, 2020, and April 30, 2020. Fourteen PLWH were diagnosed with COVID-19. Twelve patients were men and 2 were women; 13 patients were virally suppressed. Eight patients were hospitalized,
and 6 patients were told to self-quarantine at home after their diagnoses. Three patients who were admitted expired during their hospital stay. No patient required bilevel positive airway pressure or nebulizer use in the emergency department, and none developed
acute respiratory distress syndrome, pulmonary embolism, deep venous thrombosis, or a cytokine storm while on therapy for COVID-19. |
|
Guirao, A |
Infectious Disease Modelling |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
Authors model the dynamics of the epidemic in Spain over the whole span, and study the effectiveness of control measures.
Simple calculations allow anticipating the size of the epidemic based on when measures are taken and their effectiveness. The basic reproductive number in Spain was 2.5 ± 0.1 (95% CI 2.3–2.7), and the doubling time was 2.8 ± 0.1 days (95% CI 2.6–3.0). Slight
variations in measures effectiveness produce a large divergence in the epidemic size. The effectiveness in Spain was 68%, above control threshold (60%). During lockdown the reproductive number dropped to an average of 0.81 ± 0.02 (95% CI 0.77–0.85). Estimated
epidemic size is about 300,000 cases. A 7-days advance of measures yields a reduction to 38%. |
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Guo, Y, Shen, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
The aim of this paper was to study the association of COVID-19 pandemic–related impacts with health-related quality
of life in patients with skin diseases. Among the 506 respondents, 128 (25.3%) were quarantined, 102 (20.2%) reported unemployment, and 317 (62.6%) reported decrease or loss of income since the pandemic. The pandemic-related impacts were significantly associated
with impaired mental well-being and quality of life with different effects. Unemployment and complete loss of income were associated with the highest risks of adverse outcomes, with increases of 110% to 162% in the prevalence of anxiety, depression, and impaired
quality of life. |
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Critical illness-associated cerebral microbleeds in severe COVID-19 infection |
Gupta, NA, Lien, et al |
Clinical imaging |
Clinical data| Données cliniques |
Neurologic complications of COVID-19 infection have been recently described and include dizziness, headache, loss of
taste and smell, stroke, and encephalopathy. Brain MRI in these patients have revealed various findings including ischemia, hemorrhage, inflammation, and demyelination. In this article, we report a case of critical illness-associated cerebral microbleeds identified
on MRI in a patient with severe COVID-19 infection and discuss the potential etiologies of these neuroimaging findings. © 2020 Elsevier Inc. |
|
Gurung, AB, Ali, et al |
Saudi J Biol Sci |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In the present study, we have explored the possibilities of FDA approved drugs as potential inhibitors of the coronavirus
main protease. We have used a molecular docking approach and have successfully identified the best lead molecules for each enzyme target. Interestingly, the anti-migraine drugs such as ergotamine and its derivative, dihydroergotamine were found to bind to
all the three target enzymes with low binding energies. |
|
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A case of complete heart block in a COVID-19 infected patient |
Haddadin, FI, Mahdawi, et al |
Journal of Cardiology Cases |
Clinical data| Données cliniques |
We herein report the case of an elderly female with multiple comorbidities coming with typical symptoms of the viral
infection in addition to the unusual presentation of bradycardia due to complete heart block requiring pacemaker placement. |
|
Hagger, MS, Smith, et al |
Ann Behav Med |
Public Health response| Interventions de santé publique |
The study applied an integrated social cognition model to identify the determinants of social distancing behavior,
and the processes involved, in the context of the COVID-19 pandemic. Structural equation models indicated that subjective norm, moral norm, and perceived behavioral control (PBC) were consistent predictors of intention in both samples. Intention, action planning,
and habit at follow-up were consistent predictors of social distancing behavior in both samples. Action planning did not have consistent effects mediating or moderating the intention-behavior relationship. Inclusion of past behavior in the model attenuated
effects among constructs, although the effects of the determinants of intention and behavior remained. |
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Understanding the Urban Pandemic Spreading of COVID-19 with Real World Mobility Data |
Hao, Q, Chen, et al |
|
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The authors build a data-driven epidemic simulator with COVID-19 specific features, which incorporates real-world mobility
data capturing the heterogeneity in urban environments. Based on the simulator, conducted two series of experiments to: (1) estimate the efficacy of different mobility control policies on intervening the epidemic; and (2) study how the heterogeneity of urban
mobility affect the spreading process. Extensive results not only highlight the effectiveness of fine-grained targeted mobility control policies, but also uncover different levels of impact of population density and mobility strength on the spreading process. |
|
Harantová, V, Hájnik, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
This article aims at finding out what effect the measures taken (closure of public spaces, reduced access to leisure
activities, etc.) because of COVID-19 have had on the quality of traffic flow in the Slovak Republic. The results show that after the introduction of measures against the spread of coronavirus, the intensity and speed of vehicles in the measured section decreased. |
|
|
Harini, P, Abilasha, et al |
International Journal of Research in Pharmaceutical Sciences |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
The aim of the study is to create awareness about precautionary measures against COVID-19 exposure among dental practitioners
in Tamilnadu. The overall awareness of dental practitioners against Covid-19 was above average. The dental practitioners were relatively well aware of the precautions to be adopted while treating the patients, but the implementation in practice is lacking
due absence of hands-on experience in using various kinds of PPE. There is a gap between knowledge and attitude and practice among the participants of this survey. |
|
|
Hashim, BM, Al-Naseri, et al |
Science of the Total Environment |
Public health interventions*| Interventions de santé publique |
In this study, concentrations of four criteria pollutants, NO2, O3, PM2.5 and PM10 before the lockdown from January
16 to February 29, 2020, and during four periods of partial and total lockdown from March 1 to July 24, 2020, in Baghdad were analysed. NO2 concentrations decreased, O3 concentrations increased, and air quality index improved. |
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|
Hassan, ME, Hasan, et al |
Respiratory Medicine Case Reports |
Clinical data| Données cliniques |
Evidence supporting the use of dexamethasone in severe COVID-19 patients is emerging. In this case series, we share
our experience in using dexamethasone in five COVID-19 infected patients with acute respiratory distress syndrome. |
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Havnen, A, Anyan, et al |
International Journal of Environmental Research and Public Health |
Public Health response| Interventions de santé publique |
The current study investigated if resilience moderated the effect of stress on symptoms of depression and if anxiety
symptoms mediated this association. An adult sample of community controls completed the Perceived stress scale 14 (PSS-14), the Resilience scale for adults (RSA), the Patient health questionnaire 9 (PHQ-9) and the Generalized anxiety disorder 7 (GAD-7). The
results showed that resilience moderated the relations between stress and anxiety symptoms (β = −0.131, p < 0.001) as well as between stress and depressive symptoms (β = −0.068, p < 0.05). In support of a moderated mediation model, resilience moderated the
indirect effect of stress on depressive symptom, as confirmed by the index of moderated mediation (IMM = −0.036, p < 0.001; 95% BCa: −0.055, −0.020]). The high resilience subgroup was less affected than the low resilience subgroup by the effect of stress exposure
symptoms of depression, mediated by anxiety. The study shows that stress exposure is associated with symptoms of depression, and anxiety mediates this association. |
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Highly conserved binding region of ACE2 as a receptor for SARS-CoV-2 between
humans and mammals |
Hayashi, T, Abiko, et al |
Vet Q |
Coronavirology| Coronavirologie |
A comparative analysis among angiotensin-converting enzyme 2 (ACE2) homologous proteins for verifying the conservation
of specific protein regions was conducted. One of the most conserved peptides is represented by the peptide "353-KGDFR-357 (H. sapiens ACE2 residue numbering), which is located on the surface of the ACE2 molecule and participates in the binding of SARS-CoV-2
spike receptor binding domain (RBD). ACE2 works as a receptor for the SARS-CoV-2 spike glycoprotein between humans, dogs, cats, tigers, minks, and other animals, except for snakes. The three-dimensional structure of the KGDFR hosting protein region involved
in direct interactions with SARS-CoV-2 spike RBD of the mink ACE2 appears to form a loop structurally related to the human ACE2 corresponding protein loop, despite of the reduced available protein length (401 residues of the mink ACE2 available sequence vs
805 residues of the human ACE2). The multiple sequence alignments of the ACE2 proteins shows high homology and complete conservation of the five amino acid residues: 353-KGDFR-357 with humans, dogs, cats, tigers, minks, and other animals, except for snakes. |
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Co-infection with SARS-CoV-2 and parainfluenza virus in a hemodialysis patient: A case report |
He, H, Liao, et al |
Clin Nephrol |
Clinical data| Données cliniques |
Co-infection: We report a 66-year-old man with confirmed COVID-19 and parainfluenza virus infection in Wuhan. We describe
the clinical characteristics, radiological findings, and treatment of the hemodialysis patient, including the patient's initial pneumonia at presentation with progression to acute respiratory distress syndrome (ARDS). Our case underscores the possibility
of SARS-CoV-2 co-infection with other pathogens in hemodialysis patients and the importance of early identification of COVID-19. |
|
He, Linling, Lin, et al |
bioRxiv |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
We present a comprehensive vaccine strategy for SARS-CoV-2 by combining antigen optimization and nanoparticle display.
We first developed a receptor binding domain (RBD)-specific antibody column for purification and displayed the RBD on self-assembling protein nanoparticles (SApNPs) using the SpyTag/SpyCatcher system. We then identified the heptad repeat 2 (HR2) stalk as a
major cause of spike metastability, designed an HR2-deleted glycine-capped spike (S2GΔHR2), and displayed S2GΔHR2 on three SApNPs with high yield, purity, and antigenicity. Compared to the RBD, the RBD-ferritin SApNP elicited a more potent murine neutralizing
antibody (NAb) response on par with the spike. S2GΔHR2 elicited two-fold-higher NAb titers than the proline-capped spike (S2P), while S2GΔHR2 SApNPs derived from multilayered E2p and I3-01v9 60-mers elicited up to 10-fold higher NAb titers. The S2GΔHR2-presenting
I3-01v9 SApNP also induced critically needed T-cell immunity, thereby providing a next-generation vaccine candidate to battle the COVID-19 pandemic |
|
|
He, Q, Zhang, et al |
Am J Gastroenterol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This correspondence presents the clinical characteristics of COVID-19 patients with pre-existing HBV infection. |
|
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Short-Term Forecasting COVID-19 Cases In Turkey Using Long Short-Term Memory Network |
Helli, Selahattin Serdar, Demirci, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The aim of this study is to evaluate the value of Long Short-Term Memory (LSTM) Networks in forecasting the total number
of COVID-19 cases in Turkey. The COVID-19 data for 30 days, between March 24 and April 23, 2020, are used to estimate the next fifteen days. The mean absolute error of the LSTM Network for 15 days estimation is 1,69±1.35%. Whereas, for the same data, the error
of the Box-Jenkins method is 3.24±1.56%, Prophet method is 6.88±4.96% and Holt-Winters Additive method with Damped Trend is 0.47±0.28%. Additionally, when the number of deaths data is also provided with the number of total cases to the input of LSTM Network,
the mean error reduces to 0.99±0.51%. Consequently, addition of the number of deaths data to the input, results a lower error in forecasting, compared to using only the number of total cases as the input. However, Holt-Winters Additive method with Damped Trend
gives superior results to LSTM Networks in forecasting the total number of COVID-19 cases. |
|
The bug stops with me: Prevention of COVID-19 nosocomial transmission during radiographic
procedures |
Heng, AL, Ooi, et al |
Journal of Medical Imaging and Radiation Sciences |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
This article aims to describe the prevention of COVID-19 nosocomial transmission during radiographic procedures by
the utilization of stringent infection prevention measures at a leading tertiary hospital in Singapore. The implemented measures are the appropriate use of personal protective equipment, staff education, infection controls measures such as equipment disinfection,
physical distancing and segregation of staff and patients. Despite the handling of 1637 COVID-19 cases as of July 25, 2020, there has not been a single case of known nosocomial transmission of the disease in the institution. |
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Haemorrhagic bronchial casts causing complete ventilatory failure in a COVID-19 patient on
ECMO |
Herath, S, Kruit, et al |
Respirology Case Reports |
Clinical data| Données cliniques |
We present a case of an otherwise well 55-year-old female patient who had seemingly mild symptoms when she presented
to the emergency department, and then rapidly deteriorated with progressive ventilatory deficit requiring intubation, ventilation, and extracorporeal membrane oxygenation (ECMO). We present the surprise finding of haemorrhagic endobronchial casts in the airways
causing a complete ventilatory failure, managed by cryobiopsy and argon plasma coagulation (APC) leading to improved ventilation. |
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A synthetic indicator on the impact of COVID-19 on the community's health |
Herrero, C, Villar, et al |
PLoS One |
Public health interventions*| Interventions de santé publique Public Health response|
Interventions de santé publique |
We present an indicator that helps to assess the impact of Covid-19 on the community's health, combining two different
components: the extent of the pandemics (i.e. the share of the population affected) and its severity (the intensity of the disease on those affected). The severity measure derives from the application of an evaluation protocol that allows comparing population
distributions based on the proportions of those affected with different health conditions. We illustrate the functioning of this indicator over a case study regarding the situation of the Italian regions on March 9 (the beginning of the confinement) and April
8, 2020, one month later. |
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The Dutch COVID-19 approach: Regional differences in a small country |
Hoekman, LM, Smits, et al |
Health Policy and Technology |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This paper describes the first months of the COVID-19 pandemic in the Netherlands, including policies to reduce the
health-related and economic consequences. |
|
Holborow, A, Asad, et al |
Clin Med (Lond) |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The clinical false negative rate of reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2
on a single upper respiratory tract sample was calculated using convalescent antibody testing as a comparator. The sensitivity in symptomatic individuals was 86.2% (25/29). Of the missed cases, one (3.5%) was detected by repeat RT-PCR, one by CT thorax and
two (7.1%) by convalescent antibody. The clinical false negative rate of a single RT-PCR on an upper respiratory tract sample of 14% in symptomatic patients is reassuring when compared to early reports. This report supports a strategy of combining repeat swabbing,
use of acute and convalescent antibody testing and CT thorax for COVID-19 diagnosis. |
|
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COVID-19 Detection through Transfer Learning Using Multimodal Imaging Data |
Horry, MJ, Chakraborty, et al |
IEEE Access |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Authors demonstrate how transfer learning from deep learning models can be used to perform COVID-19 detection using
images from three most commonly used medical imaging modes X-Ray, Ultrasound, and CT scan. Results indicate that Ultrasound images provide superior detection accuracy compared to X-Ray and CT scans. |
|
Hossain, MT, Ahammed, et al |
PLoS One |
Public Health response| Interventions de santé publique |
Classified as a pandemic by the World Health Organization, the novel Coronavirus Disease (COVID-19) has spread to Bangladesh
since early March of 2020, and people are getting daily updates from the social and electronic media. We aimed at assessing the prevalence of anxiety among Bangladeshi people during the pandemic in connection with social media exposure (SME) and electronic
media exposure (EME). For this cross-sectional study, data were collected from 880 participants by a self-administered online-based questionnaire relating personal characteristics, self-rate health (SRH), SME, and EME with anxiety. Findings show that around
half of the surveyed population experienced a spike of anxiety (49.1%) during the pandemic, ten times higher than the national anxiety rate in 2019. The participants with an increased SME of over four hours per day experienced a higher level of anxiety than
individuals with < = 2 hours exposure to social media. Similarly, the anxiety was higher among people with fair/bad SRH compared to individuals with excellent SRH. It is highly recommended to develop active surveillance and effective monitoring systems to
reduce the spread of misinformation from both social and electronic media to improve the state of mental health conditions during the pandemic. |
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Hossam, A, Fawzy, et al |
International Journal of Microwave and Optical Technology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This paper explains in detail how different technological fields can help to fight against the COVID-19 pandemic disease
by means of innovative applications. These technological fields are such as Internet of Things (IoT), Nanotechnology, etc. On the other hand, this paper proposes a new accurate and rapid diagnostic tool that can give more accurate and faster COVID-19 test
results than the traditional used RT-PCR test and other new tool called Diffractive Phase Interferometry (DPI). Our approach uses a Raman spectroscopy technique to identify the coronavirus. The sample is taken by blowing the person through a sample chamber
that made from carbon nanotubes (CNT). Then, the viruses can be optically characterized by focusing laser light on the collected sample. As known, every virus has its own fingerprint that can distinguish the coronavirus from any other type of viruses such
as influenza. This paper introduces a performance comparison between our proposed COVID-19 diagnostic method with the traditional RT-PCR method and the DPI tool. The results showed the great ability of the proposed diagnostic tool to identify the virus easily,
quickly, and accurately compared with the existing diagnosis tools. © 2020 IAMOT. |
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Huang, A, Makridis, et al |
Int J Hosp Manag |
Economics | Économie |
Using new high-frequency data that covers a representative sample of small businesses in the United States, this study
investigates the effects of the COVID-19 pandemic and the resulting state policies on the hospitality industry. First, business closure policies are associated with a 20-30% reduction of non-salaried workers in the food/drink and leisure/entertainment sectors
during March-April of 2020. Second, business reopening policies play a statistically significant role in slowly reviving the labor market. Third, considerable differences exist in the impact of policies on the labor market by state. Fourth, the rise of new
COVID-19 cases on a daily basis is associated with the continued deterioration of the labor market. Lastly, managerial, practical, and economic implications are described. |
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Huang, J, Wang, et al |
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Public Health response| Interventions de santé publique |
To better understand the impact of COVID-19 on transportation-related behaviors and to provide more targeted anti-epidemic
measures, this study used the human mobility data collected from Baidu Maps, a widely-used Web mapping service in China, to look into the detail reaction of the people there during the pandemic. Conducted data-driven analysis on transportation-related behaviors
during the pandemic from the perspectives of 1) means of transportation, 2) type of visited venues, 3) check-in time of venues, 4) preference on "origin-destination'' distance, and 5) "origin-transportation-destination'' patterns. |
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Huang, Q, Liu, et al |
Digestive Endoscopy |
Healthcare Response | Réponse des soins de santé |
Aims: To investigate control measures for COVID-19 pandemic in GIE centers in China. Methods: This is a retrospective
multi-center research, including seven centers. Data collection was from 1 February to 31 March 2020 and the same period in 2019. Results: There were a total of 28 COVID-19 definite cases in these hospitals. Six out of seven GIE centers were arranged to shut
down on 1 February, with a mean number of shutdown days of 23.6 ± 5.3. The actual workloads were only 10.3%–62.9% compared to those last year. All centers had a preoperative COVID-19 screening process. Epidemiological questionnaire, temperature taking and
QR-code of journey were conducted. Chest CT scan was conducted during the shutdown period and continued in five centers after return to work. Antibody and nucleic acid test were applied in one to three centers. All endoscopists had advanced PPE. Five centers
used surgical mask and the rest used N95 mask. Sterilizing measures were improved in six centers. Five centers utilized ultraviolet and six centers strengthened natural ventilation. Four and six centers used peracetic acid during the period of shutdown and
return to work, alone or matched with OPA or acidified water. |
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Huizenga, Robert |
SSRN- Lancet prepublication |
Clinical data| Données cliniques |
Ten consecutive acutely-ill COVID-19 patients older than 50 years were treated with over-the-counter nicotinamide mononucleotide
(NMN), betaine, sodium chloride and zinc sulfate (NMN cocktail). Eight patients had positive nasopharyngeal SARS-CoV-2 NAA test results, one patient was clinically diagnosed with COVID-19. The NMN cocktail resulted in rapid and dramatic clinical and laboratory
improvement in older persons with complicated SARS-CoV-2 infections. |
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In an era of uncertainty: Impact of COVID-19 on dental education |
Hung, M, Licari, et al |
J Dent Educ |
Healthcare Response | Réponse des soins de santé |
This study evaluated the impact of COVID‐19 on dental education and dental students’ experience. Our findings indicate
that students are experiencing increased levels of stress and feel their clinical education has suffered. Most students appear comfortable with technology adaptations for didactic curriculum and favor masks, social distancing, and liberal use of sanitizers. |
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Huybens, EM, Bus, et al |
World J Surg |
Epidemiology| Épidémiologie Healthcare Response | Réponse des soins de santé |
To assure the proper protection without overuse of limited supply of these equipments, screening of patients before
surgical or diagnostic procedure was implemented. This study evaluates the results of this screening. Three hundred ninety-eight screenings were performed on 386 patients. The symptom questionnaire was completed in 72% of screenings. In 371 screenings, PCR
testing was performed and negative. HRCT chest found 18 cases where COVID-19 could not be excluded, with negative PCR testing. Three patients had their surgery postponed due to inconclusive screening, and additional measures were taken in three other patients.
There were incidental findings in 14% of HRCT chest scans. |
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Imami, AS, O'Donovan, et al |
Physiological genomics |
Coronavirology| Coronavirologie |
We are proposing intravenous oxytocin (OXT) as a candidate for adjunctive therapy for COVID-19. OXT has anti-inflammatory
and proimmune adaptive functions. Using the Library of Integrated Network-Based Cellular Signatures (LINCS), we used the transcriptomic signature for carbetocin, an OXT agonist, and compared it to gene knockdown signatures of inflammatory (such as interleukin
IL-1β and IL-6) and proimmune markers (including T cell and macrophage cell markers like CD40 and ARG1). We found that carbetocin's transcriptomic signature has a pattern of concordance with inflammation and immune marker knockdown signatures that are consistent
with reduction of inflammation and promotion and sustaining of immune response. This suggests that carbetocin may have potent effects in modulating inflammation, attenuating T cell inhibition, and enhancing T cell activation. Our results also suggest that
carbetocin is more effective at inducing immune cell responses than either lopinavir or hydroxychloroquine, both of which have been explored for the treatment of COVID-19. |
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Inciarte, A, Gonzalez-Cordon, et al |
Aids |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study assessed the clinical characteristics, risk factors for COVID-19 diagnosis and severity, and standardized
incidence rate ratio for COVID-19 cases in people living with HIV (PLWH) cohort and in Barcelona. From 1 March 2020 to 10 May 2020, 53 out of 5683 (0.9% confidence interval 0.7-1.2%) PLWH were diagnosed with COVID-19. Median age was 44 years, CD4 T cells
were 618/μl and CD4/CD8 was 0.90. All but two individuals were virologically suppressed. Cough (87%) and fever (82%) were the most common symptoms. Twenty-six (49%) were admitted, six (14%) had severe disease, four (8%) required ICU admission, and two (4%)
died. Several laboratory markers (lower O2 saturation and platelets, and higher leukocytes, creatinine, lactate dehydrogenase, C reactive protein, procalcitonin, and ferritin) were associated with COVID-19 severity. No HIV or antiretroviral-related factors
were associated with COVID-19 diagnosis or severity. Standardized incidence rate ratios of confirmed or confirmed/probable COVID-19 in PLWH were 38% (95% confidence interval 27-52%, P < 0.0001) and 33% (95% confidence interval 21-50%, P < 0.0001), respectively
relative to the general population. PLWH with COVID-19 did not differ from the rest of the HIV cohort. |
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Ioannidis, D, Tsagkovits, et al |
J Laryngol Otol |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
the use of a microscope drape method is proposed, to minimise aerosol spread in the wider operating theatre environment.
The efficacy of the method is assessed with a simulation model, using a CMI Concept Air Trace MK2 smoke generator for aerosol generation and a Fluke 985 air particle counter to measure air particles sized 0.3–10 μm in the operating theatre environment. Aerosol
spread was contained almost to baseline levels with the application of the drape barrier and the negative pressure created using suction within the drape. |
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Islam, MS, Tusher, et al |
Air Quality, Atmosphere and Health |
Public health interventions*| Interventions de santé publique |
The study assesses the impact of nationwide lockdown measures on air quality in Bangladesh. Analyzed satellite data
for four different air pollutants (NO2, SO2, CO, and O3) to assess the changes in the atmospheric concentrations of pollutants in major cities as well as across the country. The concentrations of NO2, SO2, CO, and O3 from 1 February to 30 May of the year 2019
and 2020 were analyzed. The average SO2 and NO2 concentrations were decreased by 43 and 40%, respectively, while tropospheric O3 were found to be increased with a maximum of > 7%. Among the major cities, Dhaka, Gazipur, Chattogram, and Narayanganj were found
to be more influenced by the restricted emissions. In Dhaka, NO2 and SO2 concentrations were decreased approximately by 69 and 67%, respectively. Analysis revealed that NO2 concentrations are highly correlated with the regional COVID-19 cases (r = 0.74). The
study concludes that the lockdown measures significantly reduced air pollution because of reduced vehicular and industrial emissions in Bangladesh. |
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COVID-19 patient health prediction using boosted random forest algorithm |
Iwendi, C, Bashir, et al |
Frontiers in Public Health |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper proposes a fine-tuned Random Forest model boosted by the AdaBoost algorithm.
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SARS CoV-2 nucleocapsid protein forms condensates
with viral genomic RNA |
Jack, Amanda, Ferro, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, we show that the N protein forms biomolecular condensates with viral RNA both in vitro and in mammalian cells.
While the N protein forms spherical assemblies with unstructured RNA, it forms mesh like-structures with viral RNA strands that contain secondary structure elements. Cross-linking mass spectrometry identified an intrinsically-disordered region that forms interactions
between N proteins in condensates, and truncation of this region disrupts phase separation. By screening 1,200 FDA approved drugs in vitro, we identified a kinase inhibitor nilotinib, which affects the morphology of N condensates in vitro and disrupts phase
separation of the N protein in vivo. These results indicate that the N protein compartmentalizes viral RNA in infected cells through liquid-liquid phase separation, and this process can be disrupted by a possible drug candidate. |
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Jack, D, Nolting, et al |
Multiple Sclerosis and Related Disorders |
Clinical data| Données cliniques |
Here we report on the cases of COVID-19 occurring in MS patients treated with cladribine tablets (Mavenclad®) within
the Merck KGaA Global Patient Safety Database. |
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Jacob, JJ, Vasudevan, et al |
Indian journal of medical microbiology |
Coronavirology| Coronavirologie Vaccine Research| Recherche sur les vaccins |
Recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and subsequent containment procedures
have impacted the world as never seen before. Therefore, there is considerable curiosity about the genome evolution related to the origin, transmission and vaccine impact of this virus. We have analysed genome sequences of SARS-CoV-2 isolated from Indian patients
to gain an in-depth understanding of genomic evolution and transmission in India. Phylogenetic analysis and mutation profiling revealed major lineages being evolved by characteristic mutations. As the mutation frequency in spike protein is comparatively lesser,
the candidate vaccines expected to have wide coverage worldwide including India. |
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The Impact of COVID-19 on the Conduct of Clinical Trials for Medical Products in
Korea |
Jeon, J, Kim, et al |
J Korean Med Sci |
Healthcare Response | Réponse des soins de santé |
This study evaluated the impact of COVID-19 and the KCDC guideline on the conduct of clinical research in Korea. The
purpose was to develop recommendations on how to minimize the risk of infection while enabling subjects to take part in the trials if no better alternative treatment options were available. Of 85 CPMs, 12% reported that trial subjects' scheduled visits had
been affected in their project. Monitors' access to hospital for source data verification was restricted at all sites in February 2020. Accordingly, 43% of 105 CPMs reported that the COVID-19 epidemic had an effect on study major milestones and data cleaning
and database lock accounted for > 60% of milestones affected. In addition, 87% sites advised not to have site initiation meetings and 52% pharmaceutical companies suspended recruitment or new study startup due to the pandemic. On the other hands, the number
of COVID-19 related clinical trials increased rapidly in Korea and worldwide, with investigator-initiated trials accounting for 47% and 63% of all trials locally and globally, respectively. Most trials were phase 2 and were in the recruitment stage. |
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Prognostic implications of neutrophil-lymphocyte
ratio in COVID-19 |
Jimeno Ruiz, S, Ventura, et al |
Eur J Clin Invest |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
DESIGN: A retrospective observational study performed at Hospital Universitario HM Puerta del Sur, Madrid, Spain, which
included 119 patients with COVID-19 from March 1 to March 31, 2020. Patients were categorized according to WHO R&D Expert Group. RESULTS: Forty five (12.1%) patients experienced severe acute respiratory failure requiring respiratory support. Forty seven (12.6%)
patients died. Those with worse outcomes were older (p=0.002) and presented significantly higher NLR at admission (p=0.001), greater increase in Peak NLR (p<0.001) and higher increasing speed of NLR (p=0.003) compared to follow up patients. In a multivariable
logistic regression, age, cardiovascular disease, C-Reactive-Protein at admission and Peak NLR were significantly associated with death. |
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Jovančević, A, Milićević, et al |
Pers Individ Dif |
Public Health Priorities| Priorités de santé publique Public Health response| Interventions
de santé publique |
The main aim of this research was to examine the role of optimism-pessimism, general trust and belief in conspiracy
theories, in COVID-19 related fears, preventive and hoarding behaviors. The results suggest that fear of food shortage was the most pronounces one in both samples, followed by fear for oneself and finally by the fear for beloved others. Results suggest that
optimists, those with high level of general trust and those who do not believe in conspiracy theories show lower level of fear and higher level of preventive behaviors. Pessimists on the other hand, show higher level of fear. Fear was related to all information
sources suggesting that more information leads to higher intensity of fear - except information from the president which did not show any effect. |
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Phylogenomic reveals multiple introductions and early
spread of SARS-CoV-2 into Peru |
Juscamayta Lopez, Eduardo, Tarazona, et al |
bioRxiv |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
To investigate early transmission event and genomic diversity of SARS-CoV-2 isolates circulating in Peru, we analyzed
a total of 3472 SARS-CoV-2 genomes, from which 149 ones were from Peru to investigate how this novel virus became established in the country and to dissect the spread of the one in this area. Phylogenomic analysis revealed multiple, independent introductions
of the virus mainly from Europe and Asia. In addition, we found evidence for community-driven transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different Peru regions. |
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Kalafat, E, Yassa, et al |
Ultrasound Obstet Gynecol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This was a retrospective cohort study conducted in two large pandemic hospitals in Turkey (Ankara University Hospital,
Ankara & Sancaktepe Training Hospital, Istanbul). Asymptomatic pregnant women admitted for delivery and symptomatic pregnant women evaluated for probable SARS-CoV-2 infection between May-June 2020 were included. There were 601 women included in the study,
and 82 (13.6%) RT-PCR proven SARS-CoV-2 infections. The addition of lung ultrasound scoring to the baseline model consisting symptom, exposure queries, and body-mass index significantly improved the prediction of RT-PCR positivity (log-likelihood: -18.1,
df:3, P <.001). The additive value of lung ultrasound was weaker for asymptomatic cases (log-likelihood: -4.523, P =.028) compared to symptomatic cases (log-likelihood: -14.8, P <.001). |
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Kamberi, F, Jaho, et al |
Archives of Psychiatric Nursing |
Public Health response| Interventions de santé publique |
The purpose of this cross-sectional study was to assess the mental health of Albanian people residing in the country
and abroad during the quarantine period for the Covid-19 pandemic. This study was carried out from 25th March – 20th April 2020 through a web survey shared on social networks. 715 participants were included in the final analyses (78.41% females and 21.53%
males). Most were residents in Albania (80.41%) and the others resided mainly in Italy (6.89%), Greece (3.51%), Germany (2.43%), Kosovo (1.62%) and the UK (1.69%). The total score of depression classification shows that 31.82% and 12.90% of participants have
respectively mild and moderate depression. Female participants showed the highest score for some items of PHQ-9, p≤0.05. |
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Kang, Y, Wang, et al |
Int Heart J |
Clinical data| Données cliniques |
An 84-year-old woman with hypertension, Alzheimer's disease, and chronic kidney disease presented with fever and was
diagnosed with corona virus disease 2019 (COVID-19). During the hospitalization, she experienced unexpected sinus bradycardia with prolonged QTc, which was thought to be closely related to the short-term use of hydroxychloroquine (HCQ), an old drug used to
treat malaria and autoimmune diseases, but now used against COVID-19. The cardiac side effects of HCQ were rare, seen with short-term and low-dose use. With the COVID-19 pandemic, this case alerts clinicians to be aware of the arrhythmogenic effects of HCQ
when it is used as an antiviral drug, especially in patients with preexisting cardiovascular diseases. |
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Obesity is a potential risk factor contributing to clinical manifestations of COVID-19 |
Kang, Z, Luo, et al |
Int J Obes (Lond) |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Authors aimed to figure out whether obesity is a risk factor influencing the progression and prognosis of COVID-19.
Our data showed that COVID-19 patients with obesity had more underlying diseases and higher mortality rate compared to those without obesity. Furthermore, patients with obesity also demonstrated more severe pathological change in lung and higher blood lymphocytes,
triglycerides, IL-6, CRP, cystatin C, alanine aminotransferase (ALT), erythrocyte sedimentation rate (ESR), which may greatly influence disease progression and poor prognosis of COVID-19. |
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The ABCs of Covid-19 prevention in Malawi: Authority, benefits, and costs of
compliance |
Kao, K, Lust, et al |
World Development |
Public Health response| Interventions de santé publique |
Which authorities can most effectively gain public compliance, and which measures will the public take up? Moreover,
do people comply with authorities out of respect for their legitimacy, due to their expertise, or for fear of sanctioning? We explore these questions using a conjoint experiment embedded in a telephone survey of 641 Malawians. Individuals in our sample are
more likely to say that they will comply with precautionary measures when the costs are low and expected benefits are high. Respondents view both traditional authorities and hospital heads as legitimately issuing directives and having the ability to monitor
and sanction non-compliance, but appear to comply more with hospital heads and to do so out of respect for their expertise. |
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Keays, G, Friedman, et al |
Health Promot Chronic Dis Prev Can |
Healthcare Response | Réponse des soins de santé |
Authors set out to investigate if emergency department (ED) visits among the pediatric population decrease was also
true for injury-related ED visits during the COVID-19 pandemic. As was the case with SARS in 2003, COVID-19 acted as a deterrent for pediatric ED visits. |
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Kerget, B, Kerget, et al |
Lung |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to investigate the relationship between serum interleukin 6 (IL-6) and surfactant protein
D (SP-D) levels and the clinical course and prognosis of COVID-19. Patients who developed acute respiratory distress syndrome had significantly higher IL-6 and SP-D levels compared to those who did not; and both parameters at the time of admission were also
significantly higher among nonsurvivors compared to survivors |
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Efficacy of Nationwide Curfew to Encounter Spread of COVID-19: A Case From Jordan |
Khatatbeh, M |
Frontiers in Public Health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
To assess the effectiveness of the lockdown, a comparison between Jordan and other countries in the Middle East would
be beneficial in terms of the total number of cases relative to date of confirming the first case and time of implementing lockdowns. The number of cases divided by the total number of population will be also considered to understand the magnitude of the disease
in each country. The number of population for each country was figured from the world live population meter, and total number of cases was figured from Johns Hopkins University's Coronavirus Resource Center, both measures as of 20th June 2020. The effectiveness
of the curfew was enhanced by the closure of all entry borders including the airport and the compulsory 14-days quarantine for all individuals arriving to Jordan within 3 days preceding closing the borders. |
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Khattab, MF, Abou-Madawi, et al |
SICOT-J |
Healthcare Response | Réponse des soins de santé Economics | Économie |
The aim of this cross-sectional online survey study was to assess the short-term effects of COVID-19 on the socioeconomic
profile of spinal surgeons in Egypt. The partial country lockdown was associated with drop in monthly income and in number of both elective and emergency operations. Most surgeons either stopped surgery or limited the number of either elective or emergency
surgeries as well as outpatient clinics. Most of them were not in the COVID-19 team or did not receive any training, working under immense physical and psychological stress of being exposed to transmission of infection. |
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COVID-19 meningitis without pulmonary involvement with positive
cerebrospinal fluid PCR |
Khodamoradi, Z, Hosseini, et al |
Eur J Neurol |
Clinical data| Données cliniques |
Case report of a 49 year old female |
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Kim, DH, Chadha, et al |
International journal of pediatric otorhinolaryngology |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
This study aimed to survey a group of global pediatric otolaryngology specialists to assess their usage and access
to personal protective equipment during the COVID-19 pandemic. 96 responses were collected from 17 different countries. N95 was the most commonly utilized PPE when dealing with COVID-19 patients (64.2%–81.9% depending on aerosolization risk of the procedure).
Significantly higher use of PAPR was noted in high-risk aerosolization generating medical procedures, when compared to other risks. Face covering was used consistently (91.6%). Most respondents (78.1%, n = 75) had access to PAPR or had at least requested it.
The majority of patients (56.2%, n = 54) was being tested for SARS-CoV-2 prior to procedures performed in operating rooms (OR); whereas, only 1.1% (n = 1) of clinic patients were tested for SARS-CoV-2 irrespective of the history or symptomatology. |
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Kim, M, Kang, et al |
|
Epidemiology| Épidémiologie |
The escalating crisis of COVID-19 has put people all over the world in danger. Owing to the high contagion rate of
the virus, COVID-19 cases continue to increase globally. To further suppress the threat of the COVID-19 pandemic and minimize its damage, it is imperative that each country monitors inbound travelers. Moreover, given that resources for quarantine are often
limited, they must be carefully allocated. In this paper, to aid in such allocation by predicting the number of inbound COVID-19 cases, we propose Hi-COVIDNet, which takes advantage of the geographic hierarchy. Hi-COVIDNet is based on a neural network with
two-level components, namely, country-level and continent-level encoders, which understand the complex relationships among foreign countries and derive their respective contagion risk to the destination country. An in-depth case study in South Korea with real-world
COVID-19 datasets confirmed the effectiveness and practicality of Hi-COVIDNet. © 2020 ACM. |
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Kimhofer, T, Lodge, et al |
J Proteome Res |
Coronavirology| Coronavirologie |
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma
were characterized using multiplatform metabolic phenotyping with nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography–mass spectrometry (LC-MS). Key discriminant metabolites included markers of inflammation including elevated α-1-acid glycoprotein
and an increased kynurenine/tryptophan ratio. There was also an abnormal lipoprotein, glucose, and amino acid signature consistent with diabetes and coronary artery disease (low total and HDL Apolipoprotein A1, low HDL triglycerides, high LDL and VLDL triglycerides),
plus multiple highly significant amino acid markers of liver dysfunction (including the elevated glutamine/glutamate and Fischer’s ratios) that present themselves as part of a distinct SARS-CoV-2 infection pattern. |
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Kimura, KS, Freeman, et al |
Int Forum Allergy Rhinol |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
Authors started an open-label randomized controlled trial to evaluate the effect of nasal irrigation with hypertonic
saline or saline with surfactant on upper respiratory symptoms and viral load. Nasal saline irrigation is a commonly accepted and inexpensive therapy with proven efficacy as a treatment for viral upper respiratory infections and has been proposed as a potentially
beneficial treatment for COVID-19. |
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Knowledge and awareness on economic impact of COVID-19 among Trichy City population-A
survey |
Kiran Srinivas, B, Gayatri Devi, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique Economics | Économie |
The main aim of this study is to test the knowledge and create awareness on various attributes that are related to
the Indian economy among the Trichy population. The questionnaire was passed to 109 individuals. Many residents from Trichy are aware about various aspects that affect our economy. Most of the responses from them were relevant and correct, emphasizing that
they are already aware in these Fields. Pandemic plays an important role in deciding a country’s economy. It shows its effects on all sectors of the government. Measures should be adopted by the citizens in order to escape from this economic fever. |
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The discounted money value of human lives lost due to COVID-19 in Spain |
Kirigia, JM, Muthuri, et al |
Journal of Health Research |
Economics | Économie |
Purpose: To estimate the discounted money value of human lives lost (DMVHL) due to COVID-19 in Spain. The 20,453 human
lives lost due to COVID-19 had a total DMVHL of Int$ 9,629,234,112, and an average of Int$ 470,798 per human life lost. |
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Evaluation of the effects of COVID-19 in a dentist’s daily routine-a survey |
Kishen, A, Anjali, et al |
International Journal of Research in Pharmaceutical Sciences |
Healthcare Response | Réponse des soins de santé |
Covid 19 is considered to be a pandemic virus infection. SARS-Cov-2 causes it. It is a viral infection that is transmitted
through aerosol and droplet contam-ination, cross-infection, etc. Dentists are at a higher risk due to this corona. It has affected daily routines of dentist’s life as they are unavailable to run the clinic and attend to patients. Different search engines
like PubMed, and Google Scholar was used. The questionnaire consisting of twenty questions was prepared by using online survey google forms and circulated among the participants. SPSS software was used to evaluate the results and data collec-tion. Statistical
analysis was done by chi-square test. Later, results were being tabulated. This survey that is taken among dental students, dentists, and ran-dom public, it is seen that the majority of them are well aware of this recent pandemic attack. (COVID-19). It is
concluded that dentists are affected to a significant extent due to coronavirus as their daily routine is affected severely. This study aims to identify the effect on dentist life on a routine basis due to the pandemic COVID-19. © 2020, J. K. Welfare and Pharmascope
Foundation. All rights reserved. |
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Kishore Babu, B, Venkateshwara Kumar, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
A study was carried out in engineering colleges of Guntur district of Andhra Pradesh. A structured questionnaire was
formulated and used to do an online survey of 384 engineering students. The questionnaire included three parts, socio-demographic characteristics, selected myths and beliefs about coronavirus. About the coronavirus majority of engineering students believed
myths are “The study reveals the respondent’s opinion on corona as below,40.4% believe that coronavirus will die off when temperatures rise in the spring, 5.1% strongly agree that social distancing guards spreading of coronavirus, 29.4% neither agree nor disagree
that Home remedies can cure and protect against COVID-19, 27.9% strongly agree. |
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Kleinpell, R, Ferraro, et al |
Crit Care Med |
Healthcare Response | Réponse des soins de santé |
This study queried U.S. ICU clinician perspectives on challenging aspects of care in managing coronavirus disease 2019
patients, current and anticipated resource demands, and personal stress. DESIGN, SETTING, AND PARTICIPANTS: Using a descriptive survey methodology, an anonymous web-based survey was administered from April 7, 2020, to April 22, 2020 (email and newsletter)
to query members of U.S. national critical care organizations. RESULTS: Through a 16-item descriptive questionnaire, ICU clinician perceptions were assessed regarding current and emerging critical ICU needs in managing the severe acute respiratory syndrome
coronavirus 2 infected patients, resource levels, concerns about being exposed to severe acute respiratory syndrome coronavirus 2, and perceived level of personal stress. The most critical ICU needs identified were personal protective equipment, specifically
N95 respirator availability, and ICU staffing. Minimizing healthcare worker virus exposure during care was believed to be the most challenging aspect of coronavirus disease 2019 patient care. |
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Etablierung der PCR-basierten SARS-CoV-2-Testung im Hochdurchsatz |
Klussmeier, A, Behrens, et al |
BioSpektrum |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we present a high-through-put approach for PCR-based SARS-CoV-2 testing. The implementation of sample pooling
reduces costs and workload, especially in times with low population prevalence. |
|
Koehler, P, Cornely, et al |
Mycoses |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
We intent to visualize aerosol and droplet spread and surface contamination during bronchoscopy and address which measures
can avoid exposure of health care workers.We created a simulation model to visualize aerosol and droplet generation as well as surface contamination by nebulizing fluorescent solution detected by using ultraviolet light and slow motion capture. Adequate personal
protective equipment and safety strategies allow to minimize contamination during bronchoscopy in mechanically ventilated COVID-19 patients. |
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Konicek, J, Netek, et al |
Data |
Epidemiology| Épidémiologie |
The application “COVID-map” is an interactive web map solution which visualizes records from the database in a spatial
way. The COVID-map has been developed within the Ad hoc online hackathon as an academic project at the Department of Geoinformatics, Palacký University Olomouc, Czech Republic. Alongside spatially localized data, the map application collects statistical data
from official sources e.g., from the governmental crisis management office. The impact of the application was immediate. Within a few days after the launch, tens of thousands users per day visited the COVID-map. It has been published by regional and national
media. The COVID-map solution could be considered as a suitable implementation of the correctly used cartographical method for the example of the coronavirus pandemic. |
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Kovac, M, Risch, et al |
Diagnostics |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
We addressed the suitability of EDTA-anticoagulated whole blood as an alternative sample material for antibody testing
against SARS-CoV-2 by electro-CLIA (ECLIA; Roche, Rotkreuz, Switzerland) and ELISA (IgG and IgA; Euroimmun, Germany). Simultaneously drawn venous serum and EDTA-anticoagulated whole blood samples from 223 individuals were included. Correction of the whole
blood results for hematocrit led to a good agreement with the serum results for weakly to moderately positive antibody signals. In receiver-operating characteristic curve analysis, all three assays displayed comparable diagnostic accuracy (area under the curve
(AUC)) using corrected whole blood and serum (AUCs: 0.97 for ECLIA and IgG ELISA; 0.84 for IgA ELISA). In conclusion, our results suggest that the investigated assays can reliably detect antibodies against SARS-CoV-2 in hemolyzed whole blood anticoagulated
with EDTA. |
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Krämer, Andreas, Billaud, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We use a machine learning-based approach to connect the viral proteins to relevant biological functions and diseases
in a large-scale knowledge graph derived from the biomedical literature. Our aim is to explore how SARS-CoV-2 could interfere with various host cell functions, and also to identify additional drug targets amongst the host genes that could potentially be modulated
against COVID-19. Results are presented in the form of interactive network visualizations, that allow exploration of underlying experimental evidence. A selection of networks is discussed in the context of recent clinical observations. |
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Krause, M, Douin, et al |
Journal of intensive care medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to identify which demographics, comorbidities, markers of disease progression, and interventions are
associated with 30-day mortality in COVID-19 patients requiring mechanical ventilation. We included 85 patients, of which 20 died (23.5%) within 30 days of the first hospital admission. In the univariate analysis, deceased patients were more likely ≥60 years
of age (p < 0.001), non-Hispanic (p = 0.026), and diagnosed with a solid malignant tumor (p = 0.003). Insurance status also differed between survivors and non-survivors (p = 0.019). Age ≥60 and malignancy had a 9.5-fold (95% confidence interval 1.4-62.3, p
= 0.020) and 5.8-fold higher odds ratio (95% confidence interval 1.2-28.4, p = 0.032) for 30-day mortality after adjusted analysis using multivariable logistic regression, while other independent variables were no longer significant. |
|
|
Kriegova, E, Fillerova, et al |
Diagnostics |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The Direct-One-Step-RT-qPCR (DIOS-RT-qPCR) assay detects severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
in less than one hour while maintaining the high sensitivity and specificity required of diagnostic tools. This optimised protocol allows for the direct use of swab transfer media (14 µL) without the need for RNA extraction, achieving comparable sensitivity
to the standard method that requires the time-consuming and costly step of RNA isolation. The limit of detection for DIOS-RT-qPCR was lower than seven copies/reaction, which translates to 550 virus copies/mL of swab. The speed, ease of use and low price of
this assay make it suitable for high-throughput screening programmes. The use of fast enzymes allows RT-qPCR to be performed under standard laboratory conditions within one hour, making it a potential point-of-care solution on high-speed cycling instruments. |
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Kroemer, M, Spehner, et al |
Journal of Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
We designed a prospective study (NCT04365322) that included 60 COVID-19 convalescent patients (1-month post infection)
in two cohorts respectively entitled mild illness and severe pneumonia. T-cell responses in term of frequency and intensity were clearly distinct between mild illness and severe pneumonia patients. |
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Kudela, J |
IEEE Access |
Public health interventions*| Interventions de santé publique |
The spread of COVID-19 and similar viruses poses new challenges for our society. There is a strong incentive towards
safety measures that help to mitigate the outbreaks. Many countries have imposed social distancing measures that require a minimum distance between people in given places, such as schools, restaurants, shops, etc. This in turn creates complications for these
places, as their function is to serve as many people as they were originally designed for. In this article, we pose the problem of using the available space in a given place, such that the social distancing measures are satisfied, as a p -dispersion problem.
We use recent algorithmic advancements, that were developed for the p -dispersion problem, and combine them with discretization schemes to find computationally attainable solutions to the p -dispersion problem and investigate the trade-off between the level
of discretization and computational efforts on one side, and the value of the optimal solution on the other. © 2013 IEEE. |
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A correlation study between meteorological parameters and COVID-19 pandemic in Mumbai,
India |
Kumar, G, Kumar, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Epidemiology| Épidémiologie |
In this study, we aim to analyze the correlation between meteorological parameters and COVID-19 pandemic in the financial
capital of India, Mumbai. Methods: In this research, we collected data from April 27 till July 25, 2020 (90 days). Results: A significant correlation of COVID-19 was found with temperature (Tmin), dew point (DPmax), relative humidity (RHmax, RHavg, RHmin)
and surface pressure (Pmax, Pavg, Pmin). The parameters which showed significant correlation were then taken for the modeling and prediction of COVID-19 infections using Artificial Neural Network technique. |
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COVID 19 mortality: Probable role of microbiome to explain disparity |
Kumar, P, Chander, et al |
Medical hypotheses |
Epidemiology| Épidémiologie |
We analyzed data from 122 countries out of which 80 were high or upper middle income and 42 were low or low middle
income countries. There was statistically significant positive correlation between COVID 19 deaths /million population and water current score, health efficiency, and expected healthy life span (HALE). We propose that high microbial exposure particularly gram
negative bacteria can possibly induce interferon type I which might have a protective effect against COVID 19 since the countries with less mortality also tend to have lack of sanitation and high incidence of attendant diseases. |
|
Kumar, Vikesh, Varshney, et al |
Research Square prepub |
Public Health response| Interventions de santé publique |
An online survey was conducted using a social media platform from 31/05/2020 to 24/06/2020. The study participants
were COVID-19 infected individuals who had recovered or still were in the recovery phase from COVID-19. Information on demographics, clinical characteristics and physical complications of COVID-19. Anxiety and depressive symptoms were assessed using previously
validated tools. 53.4% of respondents reported that they had a fear of getting COVID-19 again. Anxiety and depressive symptoms were present in 71.7% and 97.6% of respondents respectively. Both disorders were present in 71.3% of respondents. The respondents
with shorter durations of physical symptoms (< 2 weeks) demonstrated less anxiety (OR = 0.19; 95% CI: 0.05 - 0.67) and depression (OR = 0.03; 95% CI: 0.01 - 0.37). |
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A short questionnaire to assess changes in lifestyle-related behaviour during COVID
19 pandemic |
Kumari, A, Ranjan, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Public Health response| Interventions de santé publique |
his study was conducted to develop and validate a questionnaire to assess changes in individual's lifestyle-related
behaviour during COVID 19 pandemic. Materials and methods: The questionnaire was developed through a standardised methodology including literature review, focus group discussion, expert evaluation, pre-testing and validation. A cross-sectional survey was carried
out on 103 participants to validate the questionnaire that used a 5-point Likert scale for the response option. Results: We found that approximately three-fourths of the participants reported either an increased or a similar intake of main meals, snacking
between meals, portions of meals/snacks and a balanced diet including whole wheat, pulses, legumes, eggs, nuts, fruits and vegetables. On the other hand, the overall intake of fast food/junk food/fried food, sugar-sweetened beverages, sweets, chocolates has
been found to be either similar or decreased, however, the intake of unhealthy foods out of boredom or stress has been found to be a bit increased by around 20% of the participants. In the case of physical activity, we found that involvement in aerobic exercise
and household chores has either remained grossly similar or somewhat increased. |
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Stability analysis of mathematical model new corona virus (Covid-19) disease spread in
population |
Labzai, A, Kouidere, et al |
Communications in Mathematical Biology and Neuroscience |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We are building a dynamic model based on the detailed data of mortality from the World Health Organization (WHO) and
the actual spread of the epidemic. By using Routh-Hurwitz criteria and constructing Lyapunov functions, the local and the global stability of the disease-free equilibrium and the disease equilibrium are obtained. |
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Lakhani, K, Minguell, et al |
Int Orthop |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
The purpose of this study is to analyze clinical data of a series of cases who developed nosocomial infection with
SARS-CoV-2 in an orthopaedic and traumatology department. Authors found a 6.48% of nosocomial infection with SARS-CoV-2, but with an important reduction of it after undergoing preventing protocols that included screening RT-PCR test for COVID-19. |
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Lam, KW, Chow, et al |
J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study investigated continued and discontinued use of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin
II receptor blockers (ARB) during hospitalization of 614 hypertensive laboratory-confirmed COVID-19 patients. Mortality (22% vs 17%, P > .05) and intensive care unit (ICU) admission (26% vs 12%, P > .05) rates were not significantly different between non-ACEi/ARB
and ACEi/ARB groups. However, patients who continued ACEi/ARBs in the hospital had a markedly lower ICU admission rate (12% vs 26%; P = .001; odds ratio [OR] = 0.347; 95% confidence interval [CI], .187–.643) and mortality rate (6% vs 28%; P = .001; OR = 0.215;
95% CI, .101–.455) compared to patients who discontinued ACEi/ARB. The odds ratio for mortality remained significantly lower after accounting for development of hypotension or AKI. |
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Landi, F, Gremese, et al |
Journal of Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
After the acute phase of SARS-CoV-2 epidemic infection, the Fondazione Policlinico A. Gemelli IRCSS of Rome established
a post-acute care service for patients discharged from the hospital. During the first week of post-acute care activity, 29 patients recovered from COVID-19 disease were recalled being assessed. Of the 29 patients who repeated the nasopharyngeal swab, 6 patients
(20,6%) tested positive again. All these 6 patients were exposed to the SARS-CoV-2 infection at least one month before. Finally, they did not report contact with person with COVID-19 disease related symptoms, such as fever, cough, fatigue, myalgia, shortness
of breath, and sore throat and they declared no family member infected at the time of post-acute care admission, too. These findings suggest that a significant proportion of recovered COVID-19 disease patients still could be potentially asymptomatic carriers
of the virus. |
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Lauriola, M, Pani, et al |
Clin Transl Sci |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
We performed a retrospective single-center cohort study including 377 consecutive patients admitted for pneumonia related
to coronavirus disease (COVID-19). Of these 297 were in combination treatment, 17 were on hydroxychloroquine alone and 63 did not receive any of these two drugs because of contraindications. The primary endpoint was in-hospital death. Mean age was 71.8±13.4
years and 34.2% were women. We recorded 146 deaths: 35 in no treatment, 7 in hydroxychloroquine and 102 in hydroxychloroquine + azithromycin group (log-rank test for Kaplan-Meier curve p<0.001). At multivariable Cox proportional hazard regression analysis,
age (hazard ratio HR] 1.057, 95% confidence interval CI] 1.035-1.079, p<0.001), mechanical ventilation/CPAP (HR 2.726, 95%CI 1.823-4.074, p<0.001), C Reactive Protein above the median (HR 2.191, 95%CI 1.479-3.246, p<0.001) were directly associated with death,
whilst use of hydroxychloroquine + azithromycin (vs. no treatment) (HR 0.265, 95%CI 0.171-0.412, p<0.001) was inversely associated. In this study, we found a reduced in-hospital mortality in patients treated with a combination of hydroxychloroquine and azithromycin
after adjustment for comorbidities. |
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Rotational thromboelastometry in young, previously
healthy patients with SARS-Cov2 |
Lazar, M, Tomey, et al |
Journal of clinical anesthesia |
Clinical data| Données cliniques |
After obtaining consent from the patients, Rotational thromboelastometry (ROTEM) was performed on whole blood samples
collected on hospitalization day zero. ROTEM findings in both cases indicated hypercoagulability, with elevated levels of maximum clot firmness and clot amplitude at 20 min in the EXTEM; as well as elevated levels of MCF and A20 in the FIBTEM. |
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PMC7355325; Cardiac Involvment in COVID-19-Related Acute Respiratory Distress
Syndrome |
Lazzeri, C, Bonizzoli, et al |
Am J Cardiol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study assessed the cardiac involvement by serial troponin levels and echocardiograms in 28 consecutive patients
with COVID-19 ARDS consecutively admitted to ICU from March 1 to March 31. Twenty-eight COVID-19 patients (aged 61.7 ± 10 years, males 79%). The majority was mechanically ventilated (86%) and 4 patients (14%) required veno-venous extracorporeal membrane oxygenation.
As of March 31, the Intensive Care Unit mortality rate was 7%, whereas 7 patients were discharged (25%) with a length of stay of 8.2 ±5 days. At echocardiographic assessment on admission, acute core pulmonale was detected in 2 patients who required extracorporeal
membrane oxygenation support. Increased systolic arterial pressure was detected in all patients. Increased Troponin T levels were detectable in 11 patients (39%) on admission. At linear regression analysis, troponin T showed a direct relationship with C-reactive
Protein (R square: 0.082, F: 5.95, p = 0.017). |
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Objective olfactory findings in hospitalized severe COVID-19 patients |
Lechien, JR, Ducarme, et al |
Pathogens |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
Objective: We investigate the prevalence of the self-reported and objective sudden loss of smell (SLS) in patients
with severe coronavirus disease 2019 (COVID-19). Methods: Severe COVID-19 patients with self-reported SLS were recruited at hospitalization discharge. Epidemiological and clinical data were collected. The Sino-nasal Outcome Test-22 (SNOT-22) was used to evaluate
rhinological complaints. Subjective olfactory and gustatory functions were assessed with the National Health and Nutrition Examination Survey (NHNES). Objective SLS was evaluated using psychophysical tests. Potential associations between olfactory evaluation
and the clinical outcomes (duration of hospitalization; admission biology; one month serology (IgG), and chest computed tomography findings) were studied. Results: Forty-seven patients completed the study (25 females). Subjectively, eighteen (38.3%) individuals
self-reported subjective partial or total SLS. Among them, only three and four were anosmic and hyposmic, respectively (38.9%). Considering the objective evaluation in the entire cohort, the prevalence of SLS was 21.3%. Elderly patients and those with diabetes
had lower objective olfactory evaluation results than young and non-diabetic individuals. Conclusion: The prevalence of SLS in severe COVID-19 patients appears to be lower than previously estimated in mild-to-moderate COVID-19 forms. Future comparative studies
are needed to explore the predictive value of SLS for COVID-19 severity. |
|
Lee, YJ, Kim, et al |
J Korean Med Sci |
Coronavirology| Coronavirologie Infection Prevention and Control/ Prévention et contrôle
des infections (IPAC/PCI) |
We characterized the stability of SARS-CoV-2 in three water matrices: fresh, tap, and seawater. The minimum infective
dose of SARS-CoV-2 in Vero cells was confirmed to be 10³ PFU/mL. The stability of SARS-CoV-2 varied according to the water matrix: infective SARS-CoV-2 was undetectable after treatment with fresh water and seawater, but remained detectable for 2 days in tap
water, when starting with an initial concentration of 10⁴ PFU/mL. When the starting concentration was increased to 10⁵ PFU/mL, a similar trend was observed. In addition, viral RNA persisted longer than infectious virus in all water matrices. This study was
conducted in stagnant water containing a significantly high titer of virus, thus, human-to-human transmission of SARS-CoV-2 through the actual aquatic environment is expected to be rare. |
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Gastrointestinal Infection is the Risk Factor for COVID-19 Inpatients with Assisted
Ventilation |
Lei, M, Qiu, et al |
Liver Transpl |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aim to describe the clinical characteristics and risk factors of COVID-19 patients needing assisted ventilation
therapy. The retrospective study of 288 adult inpatients found that older age, tachypnea, and gastrointestinal infections showing as diarrhea, elevated ALT, and elevated white blood cells, procalcitonin and C-reactive protein were risk factors for COVID-19
inpatients with assisted ventilation. |
|
Lenza, MP, Oyenarte, et al |
Angew Chem Int Ed Engl |
Coronavirology| Coronavirologie |
The glycan structures of the receptor binding domain of the SARS-CoV2 spike glycoprotein expressed in human HEK293F
cells have been studied by using NMR. The different possible interacting epitopes have been deeply analysed and characterized, providing evidence of the presence of glycan structures not found in previous MS-based analyses. The interaction of the RBD 13C-labelled
glycans with different human lectins, which are expressed in different organs and tissues that may be affected during the infection process, has also been evaluated by NMR. In particular, 15N-labelled galectins (galectins-3, -7 and -8 N-terminal), Siglecs
(siglec-8, siglec-10), and C-type lectins (DC-SIGN, MGL) have been employed. Complementary experiments from the glycoprotein perspective or from the lectin's point of view have permitted to disentangle the specific interacting epitopes in each case. Based
on these findings, 3D models of the interacting complexes have been proposed. |
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|
Leung, WWF, Sun, et al |
Sep Purif Technol |
Public health interventions*| Interventions de santé publique Infection Prevention
and Control/ Prévention et contrôle des infections (IPAC/PCI) |
This study addresses developing novel charged polyvinylidene fluoride (PVDF) nanofiber filter technology to effectively
capture the fast-spreading, deadly airborne coronavirus, especially COVID-19, with our target aerosol size set at 100 nm. This approach was applied to develop four new nanofiber filters tailored for capturing airborne COVID-19 to achieve over 90% efficiency
with pressure drop not to exceed 30 Pa (3.1 mm water). One filter developed meeting the 90% efficiency has ultralow pressure drop of only 18 Pa while another filter meeting the 30 Pa limit has high efficiency reaching 94%. |
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Leuzinger, K, Roloff, et al |
J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Nasopharyngeal/oropharyngeal swabs (NOPS) from 7663 patients were prospectively tested by the Basel S-gene and WHO-based
E-gene (Roche) assays in parallel using the Basel N-gene assay for confirmation. Community-acquired respiratory viruses (CARVs) were prospectively tested in 2394 NOPS by multiplex nucleic acid testing, including 1816 (75%) simultaneously for SARS-CoV-2. The
Basel S-gene and Roche E-gene assays were concordant in 7475 cases (97.5%) including 825 (11%) SARS-CoV-2 positives. In 188 (2.5%) discordant cases, SARS-CoV-2 loads were significantly lower than in concordant positive ones and confirmed in 105 (1.4%). Adults
were more frequently SARS-CoV-2 positive, whereas children tested more frequently CARV positive. CARV coinfections with SARS-CoV-2 occurred in 1.8%. SARS-CoV-2 replaced CARVs within 3 weeks, reaching 48% of all detected respiratory viruses followed by rhinovirus/enterovirus
(13%), influenza virus (12%), coronavirus (9%), respiratory syncytial virus (6%), and metapneumovirus (6%). |
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Clinical value of outpatient screening in department of general surgery
during the COVID-19 outbreak |
Li, G, Zhang, et al |
Chinese Journal of Digestive Surgery |
Healthcare Response | Réponse des soins de santé |
in Chinese: During the COVID-19 outbreak, outpatient screening in department of general surgery can effectively screen
out high-risk patients. |
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vContact: Private WiFi-based Contact Tracing with Virus Lifespan |
Li, Guanyao, Hu, et al |
arXiv |
Public health interventions*| Interventions de santé publique |
In this work, we study, for the first time, automatic contact detection when the virus has a lifespan. Leveraging upon
the ubiquity of WiFi signals, we propose a novel, private, and fully distributed WiFi-based approach called vContact. Users installing an app continuously scan WiFi and store its hashed IDs. Given a confirmed case, the signals of the major places he/she visited
are then uploaded to a server and matched with the stored signals of users to detect contact. vContact is not based on phone pairing, and no information of any other users is stored locally. The confirmed case does not need to have installed the app for it
to work properly. As WiFi data are sampled sporadically, we propose efficient signal processing approaches and similarity metric to align and match signals of any time. We conduct extensive indoor and outdoor experiments to evaluate the performance of vContact.
Our results demonstrate that vContact is efficient and robust for contact detection. The precision and recall of contact detection are high (in the range of 50-90%) for close contact proximity (2m). Its performance is robust with respect to signal lengths
(AP numbers) and phone heterogeneity. By implementing vContact as an app, we present a case study to demonstrate the validity of our design in notifying its users their exposure to virus with lifespan. |
|
Li, S, Han, et al |
Frontiers in Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We analyzed the expression of ACE2 in the blood to identify the individuals who may be susceptible to infection. In
total, 229 subjects were enrolled in this study, and reverse transcription-quantitative polymerase chain reaction and ELISA assay was used to identify the level of ACE2 mRNA expression and ACE2 protein level in the blood. Higher level of ACE2 was observed
in females, older subjects, subjects with hypertension, subjects with a cardiocerebrovascular disease, male smokers, and subjects with cancer (p < 0.05) than in other subjects. Multiple linear regression analysis showed that there is a statistically significant
correlation between being a female and ACE2 expression (β = 0.550, p < 0.001), between older age and ACE2 expression (β = 0.197, p = 0.003), between smoking and ACE2 expression (β = 0.163, p = 0.037), and between cancer and ACE2 expression (β = 0.265, p <
0.001). Logistic regression analysis revealed that female subjects (odds ratio OR] = 2.255, 95% confidence interval CI] = 1.770–2.872), subjects with hypertension (OR = 1.264, 95% CI = 1.075–1.486), subjects with a cardiocerebrovascular disease (OR = 1.271,
95% CI = 1.023–1.579), subjects with cancer (OR = 1.695, 95% CI = 1.253–2.293), and subjects above 60 years of age (OR = 3.097, 95% CI = 1.078–8.896) are at an increased risk of infection due to their high expression of ACE2. |
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Drug evaluation and pharmaceutical care in a critically ill COVID-19 patient |
Li, X, Li, et al |
Int J Clin Pharmacol Ther |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
A case of a critically ill COVID-19 patient with respiratory failure and diabetes mellitus is used as an example of
an analysis of the treatment plan, utilization of combined medications, and the delivery of pharmaceutical care. Clinical pharmacists should participate in the optimization of drug treatment programs and provide pharmaceutical care for critically ill COVID-19
patients; this can promote the rational use of drugs. |
|
Li, X, Zuo, et al |
Frontiers in Pharmacology |
Healthcare Response | Réponse des soins de santé |
This study was designed to evaluate the efficacy of remote medication management of rivaroxaban by pharmacists for
geriatric patients with nonvalvular atrial fibrillation during the COVID-19 pandemic. Remote pharmacist-led medication instruction of rivaroxaban could reduce bleeding complications of the gastrointestinal tract and skin ecchymosis and postpone the first outpatient
revisit after discharge. |
|
|
Li, Y, Wu, et al |
Histopathology |
Clinical data| Données cliniques |
While diffuse alveolar damage (DAD) is recognized to be the primary manifestation COVID-19 pneumonia, there has been
little emphasis on the progression to the fibrosing phase of DAD. Authors report a detailed histopathologic study of thirty autopsy cases with COVID-19 virus infection, based on minimally invasive autopsies. |
|
|
Li, Y, Zhou, et al |
Emerg Microbes Infect |
Epidemiology| Épidémiologie Clinical data| Données cliniques Therapeutics| Thérapeutique |
The Shanghai cohort enrolled adult COVID-19 patients who were admitted to Shanghai Public Health Clinical Center. Between
20 January 2020 and 13 February 2020, a total of 311 patients were hospitalized and underwent routine laboratory tests and radiologic examinations. Stably mild patients were given systemic supportive therapy and corticosteroid was not introduced because of
potential risks. Patients were considered eligible for corticosteroids once chest radiology examinations suggested they were at risk of progression to ARDS. The proportion of patients requiring invasive mechanical ventilation was significantly lower in the
early-start group than in the control group (10.6% vs. 33.3%, difference, 22.7%, 95% confidence interval 2.6-44.8%). Among the validation cohort of 51 patients, similar difference of the primary outcome was observed (45.0% vs. 74.2%, P = 0.035). Among COVID-19
patients with marked radiologic progression, short-term, low-to-moderate-dose corticosteroids benefits patients with LDH levels of less than two times the ULN, who may be in the early phase of excessive inflammation |
|
|
Liang, J, Karagiannis, et al |
Computational Biology and Chemistry |
Coronavirology| Coronavirologie |
The SARS-CoV-2 main protease (Mpro) has an important role in the viral life cycle. Inhibition of the active site or
dimerization site of Mpro can mitigate activity. Mapping reveals a reactive pocket in the dimerization pocket at the apex of Mpro. Blind docking shows that ligands may preferentially bind at the apex of Mpro. Stable ligand interactions are formed at the active
and apex sites of Mpro. |
|
|
Liberatore, G, De Santis, et al |
Neurology |
Clinical data| Données cliniques |
Here we report the first case of Pharyngeal-Cervical-Brachial (PCB) variant of GBS associated with SARS-CoV-2 infection.
PCB is considered a rare regional axonal variant of GBS. |
|
|
Lin, C, Arevalo, et al |
Brain Behav Immun Health |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to describe the difference in clinical presentation, including race, of ischemic stroke between patients
with and without COVID-19, and the association of inflammatory response with stroke severity. 60 hospitalized patients with acute ischemic stroke were included in the analysis. Nine were positive for COVID-19. African-Americans comprised of 55.6% of those
that had COVID-19 and stroke and 37.7% of those with only stroke. Stroke patients with COVID-19 had a significantly higher NIHSS 18.4 (8.8)] and neutrophil-to-lymphocyte ratio (NLR) 7.3 (4.2) vs 3.8 (2.8); P = 0.0137] than those without. Those with COVID-19
also had a significantly higher mortality rate (44.4% vs. 7.6%; p < 0.001). |
|
|
Lin, YH, Chiang, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
This study aimed to use Google Trends data to investigate the impact of the pandemic on populations’ mental health
through three keyword searches indicating the varied extent of mental distress, namely insomnia, depression, and suicide. The countries with the greatest increases in searches for insomnia were Iran, Spain, the United States, and Italy, and these countries
showed a significant increase in insomnia searches more than 10 of the 31 days observed. The number of increased death cases was positively correlated to the number of days with an increased search for insomnia among the 19 countries, with the Spearman’s correlation
coefficient (rho) of 0.64, P = 0.003. By contrast, there was no significant correlation between increased death cases and increased searches for depression (rho = -0.12, P = 0·633) or suicide (rho = -0.07, P = 0.788). |
|
|
Lindell-Postigo, D, Zurita-Ortega, et al |
Education Sciences |
Public Health response| Interventions de santé publique |
this study aimed to analyze some demographic, physical, and psychosocial parameters in Spanish adolescents throughout
the COVID-19 quarantine through a cross-sectional investigation, establishing correlations among these factors. Methods: The present study had a descriptive, comparative, and cross-sectional design. The sample comprised of 54 (39.7%) male and 82 (60.3%) female
Spanish adolescents aged 12–18 (M = 14.49; SD = 1.80). An ad-hoc questionnaire collected sociodemographic data; the self-concept Form 5 (AF5) questionnaire obtained data on SC dimensions. Results: There were some differences among the SC dimensions, with family
and academic dimensions having higher values than the physical and emotional ones. Females’ academic SC was higher than that of males (p = 0.019). The practice of PA before the lockdown was positively associated with physical (p 0.050). |
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List, R, Compton, et al |
Telemed J E Health |
Healthcare Response | Réponse des soins de santé |
The University of Virginia's (UVA's) adult cystic fibrosis (CF) program redesigned the care model to introduced hybrid
clinics (mix of inpatient and telemedicine). The goal remained to minimize person-to-person contacts. A total of 16 hybrid visits occurred between May 14 and June 11, 2020. Each hybrid visit type was attended by an average of four CTMs and amounted to 63 separate
interactions. Of these interactions, 28 were completed virtually, reducing in-person contacts and personal protection equipment utilization by 44% compared with a fully in-person model of care. |
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Effects of wearing masks on human health and comfort during the COVID-19 pandemic |
Liu, C, Li, et al |
|
Public Health response| Interventions de santé publique |
This study explored the influence of wearing different types of masks on people's health and comfort through a subjective
questionnaire survey, physiological response test, and thermal imaging test. The results showed that, in a warm environment, wearing masks for a long time significantly affected the subjective feelings and physiological reactions of people. After wearing the
mask, the personnel feels more hot and humid, the discomfort is significantly increased. At the same time, the mean skin temperature increases, the heart rate increases, and the blood oxygen saturation level decreases, which ultimately leads to a decline in
health and comfort levels. |
|
Letter: population mortality from COVID-19 and latitude—data from
China |
Liu, N, Li, et al |
Alimentary Pharmacology and Therapeutics |
Epidemiology| Épidémiologie |
We investigated whether the case fatality rate in each province of China was related to latitude based on the available
data. The Spearman’s rank correlation co-efficient for the two data sets was 0.10 (P = 0.57). Therefore, the coefficient of determination (i.e., R2) was 0.01. Therefore, only 1% of the variance in mortality can be attributed to provinces’ latitude, which
is inconsistent with previous studies. |
|
Liu, R, Huo, et al |
Chinese Journal of Digestive Surgery |
Healthcare Response | Réponse des soins de santé |
In chinese: : The COVID-19 risk assessment scale has good safety for liver transplant recipients during the COVID-19
outbreak. It is suggested that organ transplantation can be carried out in low-risk recipients and cautiously carried out in recipients of uncertain risk, but organ transplantation should not be carried out in high-risk recipients. |
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Liu, X, Tang, et al |
J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We collected medical information of 46 confirmed patients (<1 year old) and retrospectively analyzed epidemiological
history, clinical symptoms, and laboratory test results. The median age was 5 (interquartile range, 2–7) months. Sixteen cases had fever and 27 cases had cough. Moderate disease was present in 40 cases and cardiac injury occurred in 38 cases, following by
liver dysfunction in 20 cases and lymphocytosis in no cases. Of all infant patients, 2 received invasive mechanical ventilation and 1 died with multiple organ dysfunction syndrome. |
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32853685; The association of diabetes and the prognosis of COVID-19 patients:
A retrospective study |
Liu, Z, Bai, et al |
Diabetes research and clinical practice |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study evaluated the impact of previous glycemic control and in-hospital use of antidiabetic/antihypertensive drugs
on the prognosis of COVID-19 patients with diabetes. Methods: In this retrospective cohort study, consecutive inpatients with laboratory confirmed COVID-19 were enrolled from Tongji Hospital (Wuhan, China). Patients without diabetes were matched to those with
diabetes based on age, sex, and comorbidities. All patients were followed up to a clinical endpoint (discharge, worsening including transferring to ICU or immediate death). Results: Patients with diabetes had a higher rate of worsening. Multivariable regression
showed increased odds of worsening associated with previous glycemic control reflected by HbA1c and receiver-operating characteristics (ROC) curve identified HbA1c of 8.6% (70 mmol/mol) as the optimal cut-off value. Univariate analysis demonstrated the in-hospital
use of antidiabetic/antihypertensive drugs were not associated with a higher risk of worsening. |
|
Long, Z, Alharthi, et al |
IEEE Access |
Public Health response| Interventions de santé publique |
Governments and municipalities need to understand their citizens' psychological needs in critical times and dangerous
situations. COVID-19 brings lots of challenges to deal with. We propose NeedFull, an interactive and scalable tweet analysis platform, to help governments and municipalities to understand residents' real psychological needs during those periods. The platform
mainly consists of four parts: data collection module, data storage module, data analysis module and data visualization module. The four parts interact with each other and provide users with a thorough human needs analysis based on their queries. We employed
the proposed platform to investigate the reaction of people in New York State to the ongoing worldwide COVID-19 pandemic. © 2013 IEEE. |
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Losurdo, P, Paiano, et al |
Updates Surg |
Healthcare Response | Réponse des soins de santé |
The aim of this study and the primary endpoint is to evaluate how the measures to reduce the SARS-CoV-2 spreading affected
the superficial and deep surgical site infection (SSI) rate. A total of 541 patients were included. In COVID-19 era, we reported a lower rate of global SSIs (3.3% vs. 8.4%; p 0.035), few patients developed a superficial SSIs (0.8% vs. 3.4%; p 0.018) and none
experienced deep SSIs (0% vs. 3.4%; p 0.025). Comparing the previous two "COVID-19-free" years, no significative differences were reported. At multivariate analysis, the measures to reduce the SARS-CoV-2 spread (OR 0.368; p 0.05) were independently associated
with the reduction for total, superficial and deep SSIs. Moreover, the presence of drains (OR 4.99; p 0.009) and a Type III-IV of SWC (OR 1.8; p 0.001) demonstrated a worse effect regarding the primary endpoint. Furthermore, the presence of the drain was not
associated with an increased risk of superficial and deep SSIs. |
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Network analysis and disease subnets for the SARS-CoV-2/Human interactome |
Luna, Beatriz, Ramirez, et al |
arXiv |
Coronavirology| Coronavirologie |
With the aim to amplify and make sense of interactions of virus-human proteins in the case of SARS-CoV-2, we performed
a structural analysis of the network of protein interactions obtained from the integration of three sources: 1) proteins of virus SARS-CoV-2, 2) physical interactions between SARS-CoV-2 and human proteins, 3) known interactions of these human proteins between
them and the dossier of affections in which these proteins are implicated. As a product of this research, we present two networks, one from the interactions virus-host, and the other restricted to host-host, the last one is not usually considered for network
analysis. Using the constructed networks, we establish the more significant diseases corresponding with human proteins and their connections with other proteins. It is relevant that the identified diseases coincide with comorbidities, particularly the subnetwork
of diabetes involves a great quantity of virus and human proteins (56%) and interactions (60%), this could explain the effect of this condition as an important cause of disease complications. |
|
32497798; A follow-up study of recovered patients with COVID-19 in Wuhan,
China |
Luo, S, Guo, et al |
International Journal of Infectious Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study retrospectively evaluated the data of the recovered patients with COVID-19 in two different designated fever
clinics in Wuhan, and provide clinical information about these patients. |
|
Maillart, E, Papeix, et al |
Multiple Sclerosis and Related Disorders |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMO-SD) are often treated with immunosuppressants.
Beyond their effect on the risk of COVID-19 infection, the consequences on the long-term immune response against the coronavirus remain unknown. Among 13 MS or NMOSD patients with confirmed COVID-19 included, all 5 patients treated with anti-CD20 therapies
had a negative SARS-CoV-2 serology. |
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Mairesse, A, Favresse, et al |
Clinical biochemistry |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
This study aims at assessing the analytical and clinical performance of the iFlash® anti-SARS-CoV-2 chemiluminescence
assay for the detection of both IgM and IgG antibodies. The specificity analysis was performed from 75 selected non-SARS-CoV-2 sera with a potential cross-reaction to the SARS-CoV-2 immunoassay. Results: This iFlash® SARS-CoV-2 assay showed excellent analytical
performance. After 2 weeks since symptom onset, the sensitivities for IgM and IgG were 62.2% (95%CI: 52.3–71.2%) and 92.9%% (95%CI: 85.7–96.7%), respectively by using the cut-off provided by the manufacturer. After cut-off optimization (i.e. >2.81 for IgM
and >4.86 for IgG), the sensitivity for IgM and IgG were 81.6 (95%CI: 72.7–88.1%) and 95.9% (95%CI: 89.4–98.7%), respectively. Optimized cut-off for IgG improved the sensitivity to reach 100% (95%CI: 87.6–100) from 28 days since symptom onset. |
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Maithani, S, Nautiyal, et al |
Journal of the Indian Society of Remote Sensing |
Public health interventions*| Interventions de santé publique |
The present study aims to study the effect of lockdown during COVID-19 on the spatio-temporal land surface temperature
(LST) patterns in Dehradun city. It was observed that there was an overall decrease in LST values in Dehradun city in post-COVID lockdown period. |
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Realistic estimate of the cumulative and instantaneous Covid-19 incidence in France |
Malpuech, Guillaume |
arXiv |
Epidemiology| Épidémiologie |
Based on a simple analysis of the reports of Santé Public France, we show that the real incidence during the second
wave of the Covid-19 outbreak is around 60% of the mean positivity of virological tests realized week after week in France. Simulations of the outbreak evolution based on the hypothesis of negligible reinfection probability are performed for France, Ile de
France, Puy de Dome and Bouches du Rhone. The incidence peak of 3.5 % is expected at week 39 for France. These values are 4.5 % at week 37 for Ile de France (for which the peak already passed), 4.2 % at weeks 41-42 for Puy de Dome, 7% at week 38 for Bouches
du Rhone. The calculated total number of ICU admission and deaths during the second wave are both found around 3000. The cumulative incidence over the two waves is computed close to 50 % for France and 80 % for Ile de France. We conclude that Covid-19 is much
more spread than previously thought, but its severity became very limited since the end of the first wave. |
|
Availability of Personal Protective Equipment in NHS Hospitals During COVID-19: A National
Survey |
Mantelakis, A, Spiers, et al |
Ann Work Expo Health |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
This survey assessed the availability and personal thoughts of healthcare professionals regarding PPE supply in England.
A total of 121 responses from physicians in 35 different hospitals were collected (105 inpatient wards, 16 from intensive care units). In inpatient wards, eye and face protection were unavailable to 19% (20/105). Fluid-resistant surgical masks were available
to 97% (102/105) whereas filtering facepiece class 3 (FFP3) respirator for 53% (56/105) of respondents. Gloves were accessible for all respondents (100%). Body protection was available primarily as a plastic apron 84% (88/105). All of respondents working in
intensive care had access to full-body PPE, except FFP3 respirators (available in 88%, 14/16). PPE is 'Always' available for 30% (36/121) of all respondents. There was a statistically significant difference between London and non-London respondents that 'Always'
had PPE available (44 versus 19%, P = 0.003). The results demonstrated an overall lack of PPE volume supply in the UK hospitals during March 2020, demonstrating a lack of preparedness for a pandemic. |
|
Determinants psychological distress of indonesian health care providers during COVID-19
pandemic |
Margaretha, SEPM, Effendy, et al |
Systematic Reviews in Pharmacy |
Healthcare Response | Réponse des soins de santé |
Aim: to identify determinant factors of psychological distress experienced by health care providers during the Covid-19
pandemic in Indonesia |
|
Marinho, EM, Batista de Andrade Neto, et al |
Microbial pathogenesis |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
this study aimed to evaluate in silico the molecular interactions of drugs with therapeutic indications for treatment
of COVID-19 (Azithromycin, Baricitinib and Hydroxychloroquine) and drugs with similar structures (Chloroquine, Quinacrine and Ruxolitinib) in docking models from the SARS-CoV-2 main protease (M-pro) protein. The results showed that all inhibitors bound to
the same enzyme site, however, these computer simulations are just an initial step for conceiving new projects for the development of antiviral molecules. |
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|
Marlet, J, Petillon, et al |
Journal of Clinical Virology |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The aim of the present study was to evaluate the clinical performance of four SARS-CoV-2 immunoassays and their contribution
in routine care for the diagnosis of COVID-19. The specificity was 92.1 %, 98.9 %, 100 % and 98.9 % and the sensitivity 14 days after onset of symptoms was 95.6 %, 95.6 %, 97.8 % and 95.6 % for Euroimmun IgG, Abbott IgG, Wantai Ab, and DiaPro IgG confirmation
SARS-CoV-2 immunoassays, respectively. The low specificity of Euroimmun IgG (for ratio <5) was not confirmed in routine care setting (98.5 % negative agreement). Serology was complementary to RT-PCR in routine care and lead to identification of false positive
(Ct>38, <2 targets detected) and false negative RT-PCR results (>1 month post onset of symptoms). |
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Martínez, L, Valencia, et al |
Data Brief |
Public Health response| Interventions de santé publique |
This paper presents three data sets about the consequences of COVID-19 pandemic on mental health and subjective wellbeing
in Colombia for three population subgroups: adults (+18 years old), college students, and informal workers. The data was gathered using three different online surveys in Colombia, South America. The surveys aims at informing policymakers and academics about
the consequences of COVID-19 in the wellbeing of three population groups. The information of this report aims at contributing to a broader discussion, beyond the epidemiological side, of the consequences of the pandemic on the population health. |
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Masood, G, Rizwan, et al |
Journal of the Saudi Heart Association |
Clinical data| Données cliniques |
We describe a patient with no known pre-existing cardiac condition admitted to our hospital with coronavirus disease
2019 (COVID-19) and was incidentally found to have Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA), a serious congenital malformation. To the best of our knowledge, this is the first reported case of incidentally discovered
ALCAPA in a COVID-19 patient and highlights the importance of appropriate investigation of the coronary status by Multidetector Cardiac Computed Tomographic Angiography (MDCCTA). |
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Social distancing in response to the novel coronavirus (COVID-19) in the United
States |
Masters, NB, Shih, et al |
PLoS One |
Public Health response| Interventions de santé publique |
In order to reduce the spread of SARS-CoV-2, much of the US was placed under social distancing guidelines during March
2020. We characterized risk perceptions and adherence to social distancing recommendations in March 2020 among US adults aged 18+ in an online survey with age and gender quotas to match the general US population (N = 713). We used multivariable logistic and
linear regression to estimate associations between age (by generational cohort) and these outcomes. The median perceived risk of infection with COVID-19 within the next month was 32%, and 65% of individuals were practicing more social distancing than before
the outbreak. Baby Boomers had lower perceived risk than Millennials (-10.6%, 95% CI: -16.2%, -5.0%), yet were more frequently social distancing (OR = 1.64; 95%
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Maurer, LR, Luckhurst, et al |
Journal of critical care |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Our objective was to examine the safety and efficacy of a low dose heparinized saline (LDHS) arterial line (a-line)
patency protocol. Forty-one patients (pre-LDHS) and 30 patients (post-LDHS) were identified. A LDHS protocol was associated with a clinically significant improvement in a-line patency duration in COVID-19 patients, without increased bleeding risk. |
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McCreery, CH, Katariya, et al |
|
Healthcare Response | Réponse des soins de santé |
In this paper, the authors show how a double fine-tuning approach of pretraining a neural network on medical question-answer
pairs followed by fine-tuning on medical question-question pairs is a particularly useful intermediate task for the ultimate goal of determining medical question similarity. While other pretraining tasks yield an accuracy below 78.7% on this task, this model
achieves an accuracy of 82.6% with the same number of training examples, an accuracy of 80.0% with a much smaller training set, and an accuracy of 84.5% when the full corpus of medical question-answer data is used. Also described a currently live system that
uses the trained model to match user questions to COVID-related FAQs. |
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McWilliams, D, Weblin, et al |
Ann Am Thorac Soc |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
This study describes the demographics, clinical status, level of rehabilitation and mobility status at ICU discharge
of patients with COVID-19. A total of n=177 patients were identified, of whom n=110 survived to ICU discharge and were included in the subsequent analysis. Whilst on ICU, patients required prolonged periods of mechanical ventilation (mean 19 ± 10 days), most
received neuromuscular blockade (90%) and 67% were placed in the prone position on at least one occasion. The mean ± SD time to first mobilise was 14 ± 7 days, with a median MMS at ICU discharge of 5 (interquartile range: 4-6), which represents participants
able to stand and step round to a chair with or without assistance. Time to mobilise was significantly longer in those with higher BMI (p<0.001), whilst older patients (p=0.012) and those with more comorbidities (p=0.017) were more likely to require further
rehabilitation post-discharge. |
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Mehta, B, Jannat-Khah, et al |
Seminars in arthritis and rheumatism |
Healthcare Response | Réponse des soins de santé |
The objective of this study was to investigate the perceptions and behaviors of rheumatologists in the United States
(US) regarding the risk of COVID-19 for their autoimmune patients and the subsequent management of immunosuppressive and anti-inflammatory medications. In this national sample of rheumatologists, there are variations regarding perceptions of patients’ risk
of COVID-19, and how to manage medications such as NSAIDs, biologics and steroids during the pandemic. These variations are more pronounced in geographical areas where COVID-19 disease burden was high. |
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Mehta, M, Julaiti, et al |
JMIR Public Health Surveill |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The aim of this study is to develop county-level prediction around near future disease movement for COVID-19 occurrences
using publicly available data. The model predictions showed a sensitivity over 71% and specificity over 94% for models built using data from March 14 to 31, 2020. We found that population, population density, percentage of people aged >70 years, and prevalence
of comorbidities play an important role in predicting COVID-19 occurrences. We observed a positive association at the county level between urbanicity and vulnerability to COVID-19. |
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|
Meiler, S, Schaible, et al |
European Journal of Radiology |
Clinical data| Données cliniques |
The aim of this study was to investigate if CT performed in the early disease phase can predict the course of COVID-19
pneumonia in a German cohort. 64 patients were included in the study. By univariable analysis the following parameters predicted a negative outcome: consolidation (p = 0.034), crazy paving (p = 0.004), geographic shape of opacification (p = 0.022), dilatation
of bronchi (p = 0.002), air bronchogram (p = 0.013), vessel enlargement (p = 0.014), pleural effusion (p = 0.05), bilateral disease (p = 0.004), involvement of the upper lobes (p = 0.004, p = 0.015) or the right middle lobe (p < 0.001) and severe extent of
opacifications (p = 0.002). Multivariable analysis revealed crazy paving and severe extent of parenchymal involvement to be independently predictive for a poor outcome. Easy to assess CT features in the early phase of disease independently predicted an adverse
outcome of patients with COVID-19 pneumonia. |
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Meister, TL, Brüggemann, et al |
J Infect Dis |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Here, we evaluated the virucidal activity of different available oral rinses against SARS-CoV-2 under conditions mimicking
nasopharyngeal secretions. Several formulations with significant SARS-CoV-2 inactivating properties in vitro support the idea that oral rinsing might reduce the viral load of saliva and could thus lower the transmission of SARS-CoV-2. |
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Meleveedu, KS, Miskovsky, et al |
Cytokine X |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We sought to describe outcomes in a series of severely ill patients with COVID-19 CRS following treatment with anti-IL-6/IL-6-Receptor
(anti-IL-6/IL-6-R) therapy, including tocilizumab or siltuximab. At our academic community medical center, we formed a multi-disciplinary committee for selecting severely ill COVID-19 patients for therapy with anti-IL-6 or IL-6-R agents. we treated 31 patients
with anti-IL-6/IL-6-R agents including 12 who had already been intubated. Overall, 27 (87%) patients are alive and 24 (77%) have been discharged from the hospital. Clinical responses to anti-IL-6/IL-6-R therapy were accompanied by significant decreases in
temperature, oxygen requirement, CRP, IL-6, and IL-10 levels. Based on these data, we believe anti-IL-6/IL-6-R therapy can be effective in managing early CRS related to COVID-19 disease. |
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SARS-CoV-2 and the safety margins of cell-based biological medicinal products |
Modrof, J, Kerschbaum, et al |
Biologicals |
Coronavirology| Coronavirologie |
This study investigated four widely used biomanufacturing cell lines, i.e. CHO and Vero, as well as the two human cell
lines HEK-293 and HT- 1080, for their susceptibility to infection with SARS-CoV-2. Permissiveness for proliferation of SARS-CoV-2 was confirmed for Vero cells, but was absent for CHO, HT-1080 and MRC-5 cells. HEK-293 cells did not show productive amplification
of SARS-CoV-2 although some minimal and self-limiting replication may be possible. lls, no “si-lent” infection of SARS-CoV-2 did occur, i.e. virus replication but no development of detectable CPE, as a “silent” virus replication would have been detected by
the titration of supernatants on Vero cells |
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Awareness on the possible role of ayurveda as an immunity booster in the covid19
pandemic |
Mohamed Arsaath, N, Gheena, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
This study was carried out to analyse the awareness of people on Ayurveda being a possible option for boosting our
immunity. An online survey was conducted with a self-structured questionnaire using an online survey platform google forms. A total of 100 responses were received. The responses recorded from the participants showed that the participants possess adequate knowledge
about the covid19 infection, and they possess sufficient awareness of the possible role of Ayurveda on boosting immunity against covid19. 83.9% of the respondents are aware of the pandemic outbreak covid19, and among them, 59.5% believe that Ayurveda plays
a role in boosting immunity against covid19. Around 50% of the participants believe herbs used in Ayurveda are potential inhibitors against covid19. |
|
Mohammad, M, Trounev, et al |
Chaos Solitons Fractals |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Transmission |
Many scientists proposed new models to best describe the dynamics of all possible parameters responsible for the daily
cases reported including deaths, control the fatality rate, and prediction of COVID-19 behavior in future within a specific region. It is known that several models can describe the same system, which is a challenging step. In this paper we intend to formulate
a new mathematical model of Corona virus based on the model presented in Ndaïrou et al. [11] based on ABFD. The numerical method simulation is conducted via the framelet system generated using Daubechies scaling functions. |
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Mohammed, SN, Alkinani, et al |
International Journal of Intelligent Engineering and Systems |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
An automated Computer Aided Diagnostic (CAD) system for COVID-19 based on chest X-Ray image analysis is presented in
this article. It is designed for COVID-19 recognition from other MERS, SARS, and ARDS viral pneumonia. The optimal threshold value for the segmentation of a chest image is deduced by exploiting Li s' method and particle swarm intelligence. Laws' masks are
then applied to the segmented chest image for secondary characteristics highlighting. After that, nine different vectors of attributes are extracted from the Grey Level Co-occurrence Matrix (GLCM) representation of each Law's mask result. Support vector machine
ensemble models are then built based on the extracted feature vectors. Finally, a weighted voting method is utilized to combine the decisions of ensemble classifiers. Experimental findings show an accuracy of 98.04 %. It indicates that the suggested CAD scheme
can be a promising supplementary COVID-19 diagnostic tool for clinical doctors. |
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Montalvo Villalba, MC, Valdés Ramírez, et al |
Clinical Immunology |
Clinical data| Données cliniques |
Twenty healthy persons, SARS-CoV-2 negative were included as controls. Higher IFN-γ expression was detected in SARS-CoV-2
infected patients in comparison with controls (p = 0.0393). IFN-γ expression was increased in symptomatic patients (p = 0.0405). TGF-β1 and RANTES expressions were lower in SARS-CoV-2 infected patients than controls (p < 0.0001; p = 0.0011, respectively).
A significant correlation between IFN-γ and TGF-β1 was observed in SARS-CoV-2 asymptomatic patients (r = +0.61, p = 0.0014). The findings suggest that imbalance between IFN-γ and TGF-β1 expression could be an impact in clinical expression of SARS-CoV-2 infection |
|
|
Montenegro, P, Brotons, et al |
Fam Pract |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
We aim to measure the seroprevalence of antibodies against SARS-CoV-2 infection in a community sample of possible cases
and among probable cases followed in primary care. We selected a random sample of 600 individuals stratified by age groups from a total population of 19 899 individuals from a community area in Barcelona. We also invited all the patients that had been followed
by General Practitioners (GPs). Three hundred and eleven asymptomatic individuals from the randomly selected sample participated in the study. The mean age was 43.7 years standard deviation (SD) = 21.79] and 55% were women. Seventeen individuals were seropositive
for IgM and/or IgG, resulting in an overall prevalence of 5.47% (95% confidence interval = 3.44-8.58). Six hundred and thirty-four symptomatic patients were followed up by GPs. The mean age was 46.97 years (SD = 20.05) and 57.73% were women. Of these, 244
patients (38.49%) were seropositive. Results of the multivariate logistic regression analysis showed that the odds ratio for a positive test was significantly increased in patients who had fever, ageusia and contact with a patient diagnosed with COVID-19. |
|
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Monzani, D, Gorini, et al |
Personality and Individual Differences |
Public Health Priorities| Priorités de santé publique Public Health response| Interventions
de santé publique |
In the present study, we focused on the relationship between dispositional optimism (DO) and optimistic bias (OB) when
reporting the personal and the other persons' risk about COVID-19. A convenience sample of 414 Italian participants aged 18 or older were recruited. They completed a questionnaire investigating past protective behaviors, DO, perceived personal and other persons'
COVID-19-related risk. Results of the mixed regression model showed that more optimistic people were more likely to underestimate their COVID-19 personal risk over the other's person risk. |
|
|
Moon, SS, Lee, et al |
J Korean Med Sci |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In Korea, a religious group-related super-spreading event triggered a sudden outbreak in Daegu city and Gyeongsangbuk-do
in southeast Korea. This study was undertaken to document the clinical characteristics of patients hospitalized in Gyeongsangbuk-do. The most common symptom was cough (31.8%) followed by a febrile sensation (28.4%), sputum (17.0%), sore throat (15.6%), and
myalgia (13.1%). Eighty-one (23.0%) patients were asymptomatic, but a half of these patients exhibited pneumonic infiltration at presentation. Chest radiology showed no active lesion in 41.8% of the study subjects, bilateral pneumonia in 46.9%, and unilateral
pneumonic infiltration in 11.4%. Among 24 patients that died, 18 subjects were transferred from a care facility. An age of ≥ 70 years, previous history of malignancy or diabetes, and fever (≥ 37.5°C) on admission were found to be significant risk factors of
mortality |
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|
Morales, P, Curtis, et al |
Catalysts |
Coronavirology| Coronavirologie |
NSP16 is a S-adenosyl-L-Methionine (SAM) dependent 2′ O-Methyltransferase that converts mRNA cap-0 into cap-1 structure
to prevent virus detection by cell innate immunity mechanisms. NSP16 methylates the ribose 2′ O-position of the first nucleotide of the mRNA only in the presence of an interacting partner, the protein NSP10. This feature suggests that inhibition of the NSP16
may represent a therapeutic window to treat COVID-19. To test this idea, we performed comparative structural analyses of the NSP16 present in human coronaviruses and developed a sinefungin (SFG) similarity-based virtual screening campaign to assess the druggability
of the SARS-CoV-2 NSP16 enzyme. Through these studies, we identified the SFG analogue 44601604 as a promising more potent inhibitor of NSP16 to limit viral replication in infected cells, favouring viral clearance. |
|
|
Morgenthau, AS, Levin, et al |
Lung |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigate whether sarcoidosis patients infected with SARS-CoV-2 are at risk for adverse disease outcomes. This
retrospective study was conducted in five hospitals within the Mount Sinai Health System (New York) during March 1, 2020 to July 29, 2020. All patients diagnosed with COVID-19 were included in the study. Moderate or severe impairment in pulmonary function
is associated with mortality in sarcoidosis patients infected with SARS‑CoV‑2. |
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Morollón, N, Belvís, et al |
Neurologia |
Healthcare Response | Réponse des soins de santé |
We collected information on the opinions of scientific societies and medicines agencies (American, European, and Spanish)
to clarify doubts regarding the use of drugs such as lisinopril, candesartan, ibuprofen, corticosteroids, carbamazepine, and monoclonal antibodies targeting the calcitonin gene–related peptide in the context of the COVID-19 pandemic. At present, there is no
robust scientific argument to formally contraindicate any of the standard treatments employed for headaches and neuralgias. |
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Morrone, KA, Strumph, et al |
Pediatric Blood and Cancer |
Clinical data| Données cliniques |
New York City has emerged as one of the epicenters of the SARS-COV-2 pandemic, with the Bronx being disproportionately
affected. This novel coronavirus has caused significant respiratory manifestations raising the concern for development of acute chest syndrome (ACS) in patients with sickle cell disease (SCD). We report a series of pediatric SCD SARS-COV-2-positive patients
admitted with ACS. SARS-COV-2-positive SCD patients, who did not develop ACS, were the comparison group. Hydroxyurea use (P-value =.02) and lower absolute monocyte counts (P-value =.04) were noted in patients who did not develop ACS. These preliminary findings
need to be further evaluated in larger cohorts. © 2020 Wiley Periodicals LLC |
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Mujahidin, E, Bahruddin, et al |
Yakugaku Zasshi |
Public Health response| Interventions de santé publique |
The purpose of this study is to look at the role of meeting zoom applications in improving productivity and health
management of students in the midst of the corona or covid-19 virus pandemic in Bogor City. The study was conducted with a study population of 260 and a sample selection of 160 students spreading across several universities. The results showed that: (1) The
use of meeting applications such as zoom can increase student productivity so that insight and space can be free. (2) The use of meeting applications such as zoom used by students can narrow the spread of the corona virus because students minimize outdoor
activities. (3) The role of meeting applications using zoom emphasizes cost, energy and time but does not reduce the essence of science obtained by a student. Even students can conduct a deeper study of the science. The results showed that the use of the meeting
zoom application has a positive influence on productivity with the Sobel test results of 0.087 with a p value of 0.072. |
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Murohashi, K, Hagiwara, et al |
Respiratory Investigation |
Clinical data| Données cliniques |
Here, we report the successful treatment of 11 cases of severe COVID-19 pneumonia with favipiravir and methylprednisolone.
All cases were severe and patients required oxygen administration or had a blood oxygen saturation ≤93% on room air. 10 of 11 patients responded well and required no further oxygen supplementation or ventilator management. |
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Covid19: Unless one gets everyone to act, policies may be ineffective or even
backfire |
Muscillo, A, Pin, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
The diffusion of Covid-19 has called governments and public health authorities to interventions aiming at limiting
new infections and containing the expected number of critical cases and deaths. Most of these measures rely on the compliance of people, who are asked to reduce their social contacts to a minimum. In this note we argue that individuals' adherence to prescriptions
and reduction of social activity may not be efficacious if not implemented robustly on all social groups, especially on those characterized by intense mixing patterns. Actually, it is possible that, if those who have many contacts have reduced them proportionally
less than those who have few, then the effect of a policy could have backfired: the disease has taken more time to die out, up to the point that it has become endemic. In a nutshell, unless one gets everyone to act, and specifically those who have more contacts,
a policy may even be counterproductive. |
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Musoke, N, Lo, et al |
Thrombosis research |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Single center retrospective analysis of 355 adult patients with confirmed diagnosis of COVID-19 from March 1 to May
31, 2020. |
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Naderipour, A, Abdul-Malek, et al |
Environmental Technology and Innovation |
Public health interventions*| Interventions de santé publique |
This study aims to show the potential positive effects of COVID-19 on the environment and the increase of renewable
energy generation in Malaysia. To prevent the spread of this disease, Malaysia enacted the Movement Control Order (MCO) law in March 2020. Implementation of this law led to a reduction in environmental pollution, especially air pollution, in this country.
The greenhouse gases (GHG) emission, which was 8 Mt CO2 eq. from January 2020 to March 2020, reduced to <1 Mt CO2 eq. for April and May. The reduction of GHG emission and pollutant gases allowed more sunlight to reach photovoltaic panels, hence increasing
the renewable energy generation. |
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Naji, KK, Du, et al |
Eurasia Journal of Mathematics, Science and Technology Education |
Public Health response| Interventions de santé publique |
This study examined engineering students' initial readiness to transition to emergency online learning in response
to COVID-19 in Qatar. Sequential explanatory mixed-method research was conducted, with 140 participants completing an online survey, of which 68 also contributed written reflections and 8 participated in semi-structured interviews. The qualitative outcomes
supported the four factors and provided further insight into their varied and nuanced manifestation. In accounting for the perceived impact of the factors on readiness, significant differences were identified regarding pedagogical mode, with students enrolled
in PBL courses reporting higher readiness than those from non-PBL courses. |
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national, Covid-outbreak monitoring group, National, et al |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin |
Epidemiology| Épidémiologie |
For the purpose of this study, we also took into account four outbreaks that had been notified end of May 2020, just
before the official adjustment of the national strategy. Including these, from approximately mid-June up to 2 August (end of week 31), a total of 673 COVID-19 outbreaks affecting more than 8,300 persons had been notified to the national level in Spain. Of
these, 551 outbreaks with more than 6,200 cases, were active on 2 August. At that point, all but one Spanish region had notified outbreaks. The analysis of outbreaks with date of onset of symptoms of the first case after 1 June showed that their numbers increased
during June and mid-July. |
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Navascues, Miguel, Budroni, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
Traditionally, expert epidemiologists devise policies for disease control through a mixture of intuition and brute
force. Namely, they use their know-how to narrow down the set of logically conceivable policies to a small family described by a few parameters, following which they conduct a grid search to identify the optimal policy within the set. This scheme is not scalable,
in the sense that, when used to optimize over policies which depend on many parameters, it would likely fail to output an optimal disease policy in time for its implementation. In this article, we use techniques from convex optimization theory and machine
learning to conduct optimizations over disease policies described by hundreds of parameters. We illustrate our approach by minimizing the total time required to eradicate COVID-19 within the Susceptible-Exposed-Infected-Recovered (SEIR) model proposed by Kissler
et al. (March, 2020). We observe that optimal policies are typically very complex, and thus unlikely to be discovered by a human agent. |
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Nekliudov, NA, Blyuss, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
This study aims to evaluate confidence, understanding, trust, concerns, and levels of anxiety during the COVID-19 pandemic
in the general population and assess risk factors for increased anxiety. Among Russian respondents from multiple social media platforms, there was evidence of higher levels of state anxiety associated with recent job loss and increased news consumption, as
well as lower than expected trust in government agencies. |
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32669322; AKI in Hospitalized Patients with and without COVID-19: A Comparison Study |
Neugarten, J, Bellin, et al |
Journal of the American Society of Nephrology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
In a retrospective observational study, we evaluated AKI incidence, risk factors, and outcomes for 3345 adults with
COVID-19 and 1265 without COVID-19 who were hospitalized in a large New York City health system and compared them with a historical cohort of 9859 individuals hospitalized a year earlier in the same health system. We found higher AKI incidence among patients
with COVID-19 compared with the historical cohort (56.9% versus 25.1%, respectively). Factors that were predictive of stage 2 or 3 AKI included initial respiratory rate, white blood cell count, neutrophil/ lymphocyte ratio, and lactate dehydrogenase level. |
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Nindrea, RD, Sari, et al |
Data Brief |
Public Health response| Interventions de santé publique |
This set of data presents a survey data describing multidrug-resistant tuberculosis, tuberculosis patients characteristics
and stress resilience during COVID-19 pandemic in West Sumatera Province, Indonesia. The data were gathered from multidrug-resistant tuberculosis, tuberculosis patients through a survey distributed by an online questionnaire, assesing patients characteristics
(age, sex, level of education, working status, history of close contact to patients with multidrug resistant tuberculosis and tuberculosis, smoking, alcohol consumption, cavitary pulmonary, diabetes mellitus, nutritional status and tuberculosis outside the
lung) and stress resilience (3 items), from 15th July until 7th August 2020. The samples were collected 73 multidrug resistant tuberculosis patients and 219 tuberculosis patients in West Sumatera Province, Indonesia who were willing to fill an online questionnaire. |
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Nogami, Y, Kobayashi, et al |
J Ovarian Res |
Healthcare Response | Réponse des soins de santé |
During the epidemic phase of an emerging infectious disease, we found that COVID-19 has several other effects besides
its incidence. Two asymptomatic RT-PCR-positive patients did not develop COVID-19, but their treatment was delayed until the confirmation of negative results. The other three patients were RT-PCR-negative, but abnormal CT findings suggested the possibility
of COVID-19, which delayed treatment. The patients receiving first-line preoperative chemotherapy for ovarian cancer had clinically evident exacerbations because of the treatment delay. The postponing treatment was the most common, therefore, treatment of
ovarian tumors and ovarian cancer was considered to be the most likely to be affected among gynecological diseases. |
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Analysis of ACE2 genetic variants in 131 Italian SARS-CoV-2-positive patients |
Novelli, A, Biancolella, et al |
Hum Genomics |
Coronavirology| Coronavirologie |
Authors analyzed, by whole-exome sequencing, genetic variants of ACE2 gene in 131 DNA samples of COVID-19 patients
hospitalized at Tor Vergata University Hospital and at Bambino Gesù Children’s Hospital, Rome.
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32860817; High rates of SARS-CoV-2 seropositivity
in nursing home residents |
Nsn, G, C, et al |
Journal of Infection |
Epidemiology| Épidémiologie Immunology | Immunologie |
During March-April 2020 we investigated outbreaks in four UK nursing homes where 40% of 394 residents tested positive
on RT-PCR, of whom 43% had no identifiable symptoms in the preceding two week period. Seventy two percent of nursing home residents (95% CI 66 – 77) were anti-SARS-CoV-2 IgG antibody positive, representing 173 of 241 residents available and consenting to testing.
Of residents who had previously tested positive by RT-PCR, 93% had developed antibodies (95% CI 85 – 96; 87 of 94) and 59% of those who were previously RT-PCR negative were antibody positive (95% CI 50 – 66, 86 of 147).35% of antibody positive residents (95%
CI 29 – 43, 62 of 173) had been asymptomatic in the two-week ascertainment window prior to PCR testing during the outbreak. Seropositivity was not associated with the presence of comorbidities. |
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Co-diagnoses of acute myeloid leukaemia and COVID-19: presentation and management implications |
O'Brien, A, Campling, et al |
Respirology Case Reports |
Clinical data| Données cliniques |
We report a case of concurrent new diagnoses of confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection and acute myeloid leukaemia (AML). We review the existing literature on coronavirus disease 2019 (COVID-19) in the immunocompromised patient and the implications for managing our patient's haematological neoplasm. |
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Co-diagnoses of acute myeloid leukaemia and COVID-19: presentation and management implications |
O'Brien, A, Campling, et al |
Respirology Case Reports |
Clinical data| Données cliniques |
We report a case of concurrent new diagnoses of confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection and acute myeloid leukaemia (AML). We review the existing literature on coronavirus disease 2019 (COVID-19) in the immunocompromised patient and the implications for managing our patient's haematological neoplasm. |
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Öcal, A, Cvetković, et al |
Geomatics, Natural Hazards and Risk |
Public Health response| Interventions de santé publique |
This study aimed to investigate people’s emotional reactions to the COVID-19 pandemic.
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Octaberlina, LR, Muslimin, et al |
International Journal of Higher Education |
Public Health response| Interventions de santé publique |
The present research depicted the online learning barriers faced by students as well as their alternatives to cope
them. The research implemented a descriptive mixed-method survey design. The participants were 25 students from the English Education Department. The results showed that students experienced three barriers during online learning including unfamiliarity of
e-learning, slow internet connection, and physical condition e.g. eye strain. The alternatives they proposed were providing training to implement the LMS before the real class, converting high-definition or big-size files into smaller ones, and giving break
during the online class. The conclusion stated that students had to be creatives to find any solutions and innovations regarding learning barriers including maintaining good communication with teacher and understanding the best learning styles individually. |
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One COVID, Three Americas: Dynamic Panel Surveillance to Inform Health Policy |
Oehmke, JF, Moss, et al |
J Med Internet Res |
Epidemiology| Épidémiologie |
This surveillance study applies state-of-the-art statistical modeling to existing data extracted from the internet
state government tallies of Covid infections to calculate the best available estimates of the state-level dynamics of Covid-19 infection. The results indicate 1) that the statistical approach is valid, including for determining recent changes in the pattern
of infection, and 2) during the weeks of June 13th -19th and 20th-26th the evolution of the pandemic changed with greater inter-temporal persistence of the infection rate. This change represents an increase in the contagion model R value for those periods,
and is consistent with a reemergence of the pandemic. |
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Olaleye, OmonikeA, Kaur, et al |
bioRxiv |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
Herein, we discovered that Ambroxol hydrochloride (AMB), and its progenitor, Bromhexine hydrochloride (BHH), both clinically
approved drugs are potent effective modulators of the key interaction between the receptor binding domain (RBD) of SARS-CoV-2 spike protein and human ACE2. We also found that both compounds inhibited SARS-CoV-2 infection-induced cytopathic effect at micromolar
concentrations. Therefore, in addition to the known TMPRSS2 activity of BHH; we report for the first time that the BHH and AMB pharmacophore has the capacity to target and modulate yet another key protein-protein interaction essential for the two known SARS-CoV-2
entry pathways into host cells. Altogether, the potent efficacy, excellent safety and pharmacologic profile of both drugs along with their affordability and availability, makes them promising candidates for drug repurposing as possible prophylactic and/or
treatment options against SARS-CoV-2 infection. |
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Oliveira, Ana Sofia, Ibarra, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, we use molecular simulations of validated atomically detailed structures of nicotinic acetylcholine receptors
(nAChRs), and of the S protein, to investigate this "nicotinic hypothesis". We examine the binding of the Y674-R685 loop of the S protein to three nAChRs, namely the human α4β2 and α7 subtypes and the muscle-like αβγδ receptor from Tetronarce californica.
Our results indicate that Y674-R685 has affinity for nAChRs and the region responsible for binding contains the PRRA motif, a four-residue insertion not found in other SARS-like coronaviruses. In particular, R682 has a key role in the stabilisation of the
complexes as it forms interactions with loops A, B and C in the receptors binding pocket. The conformational behaviour of the bound Y674-R685 region is highly dependent on the receptor subtype, adopting extended conformations in the α4β2 and α7 complexes and
more compact ones when bound to the muscle-like receptor. Analyses of the simulations of the full-length S protein show that the Y674-R685 region is accessible for binding, and suggest a potential binding orientation of the S protein with nAChRs. |
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COVID-19 Related Mobility Reduction: Heterogenous Effects on Sleep and Physical Activity
Rhythms |
Ong, JL, Lau, et al |
Sleep |
Public Health response| Interventions de santé publique |
We characterize how COVID-19 associated mobility restrictions shifted sleep and physical activity patterns from previously
established baselines using objective, longitudinal measurements. Time in bed increased by 20 min during the lockdown without loss of sleep efficiency, while social jetlag measures decreased by 15 min. Physical activity dropped an average of 42%. The least
active group comprising ~51% of the sample, were younger and predominantly singles. |
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32779378; Dupilumab in atopic dermatitis, a protocol for SARS-COV-2-infected patients |
Ordóñez-Rubiano, MF, Campo, et al |
Dermatologic Therapy |
Clinical data| Données cliniques |
Case report of a 22 year old male nurse with atopic dermatitis and was diagnosed with asymptomative SARS-CoV-2. |
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Orro, A, Novales, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
This study analyzes the changes in transit ridership by line, the use of stops, the main origin–destination flows,
changes in transit supply, operation time, and reliability of the city bus network of A Coruña. The impact on transit ridership during the lockdown process was more significant than that on general traffic. In the new normal situation, the general traffic
and the shared bike system recovered a higher percentage of their previous use than the bus system. These impacts are not uniform across the bus network. |
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Dynamic changes in fibrinogen and D-dimer levels in COVID-19
patients on nafamostat mesylate |
Osawa, I, Okamoto, et al |
J Thromb Thrombolysis |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
we retrospectively conducted a cluster analysis based on clinical characteristics on admission to identify latent subgroups
among fifteen patients with COVID-19 on nafamostat mesylate at the University of Tokyo Hospital, Japan, between April 6 and May 31, 2020. Next, we delineated the characteristics of all patients as well as COVID-19-patient subgroups and compared dynamic changes
in coagulation factors among each subgroup. All COVID-19 patients were
classified into three subgroups: clusters A, B, and C, representing low, intermediate, and high risk of poor outcomes, respectively. All patients were alive 30 days from symptom onset. No patient in cluster A required mechanical ventilation; however, all patients
in cluster C required mechanical ventilation, and half of them were treated with venovenous extracorporeal membrane oxygenation. All patients in cluster A maintained low D-dimer levels, but some critical patients in clusters B and C showed dynamic changes
in fibrinogen and D-dimer levels. |
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Otaif, W, Al Somali, et al |
Am J Ophthalmol Case Rep |
Clinical data| Données cliniques |
This case report describes a case of episcleritis that appeared to be the first sign of the novel coronavirus disease
(COVID-19) in a 29-year-old man with no prior medical condition presented with a complaint of redness and foreign body sensation in his left eye, which started two days before his consultation. A diagnosis of episcleritis was made based on clinical grounds
and topical fluorometholone 0.1%. was started. Three days later, the patient presented with headache, shortness of breath, cough, and fever (39.2 °C). Real-time fluorescence polymerase chain reaction test of his nasopharyngeal swab returned a positive result
for COVID-19. The patient was then admitted for observation and supportive therapy. After five days, fever, respiratory and ocular symptoms were markedly improved and the patient was discharged and advised to isolate at home for 14 days. |
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Ouchicha, C, Ammor, et al |
Chaos Solitons Fractals |
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
In this paper, we propose CVDNet, a Deep Convolutional Neural Network (CNN) model to classify COVID-19 infection from
normal and other pneumonia cases using chest X-ray images. The proposed architecture is based on the residual neural network and it is constructed by using two parallel levels with different kernel sizes to capture local and global features of the inputs.
This model is trained on a dataset publically available containing a combination of 219 COVID-19, 1341 normal and 1345 viral pneumonia chest x-ray images. The experimental results reveal that our CVDNet. These results represent a promising classification performance
on a small dataset which can be further achieve better results with more training data. Overall, our CVDNet model can be an interesting tool to help radiologists in the diagnosis and early detection of COVID-19 cases. |
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32864352; Covid-19 – The availability of icu beds in Brazil during the onset of pandemic |
Palamim, CVC, Marson, et al |
Annals of Global Health |
Healthcare Response | Réponse des soins de santé |
This study described and intercorrelated epidemiology and geographic data from Brazil about the number of intensive
care unit (ICU) beds at the onset of COVID-19 pandemic. The distribution of ICUs was uneven between public and private services, and most patients rely on ICU beds/10,000 inhabitants for the public (SUS), which had the lowest number of ICU beds. In only a
few states, the number of ICU beds at SUS was above 1 to 3 by 10,000 inhabitants, which is the number recommended by the World Health Organization (WHO). |
|
Park, SW, Bolker, et al |
Journal of the Royal Society Interface |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Here, we present a statistical framework for comparing and combining different estimates of R0 across a wide range
of models by decomposing the basic reproductive number into three key quantities: the exponential growth rate, the mean generation interval and the generation-interval dispersion. We apply our framework to early estimates of R0 for the SARS-CoV-2 outbreak,
showing that many R0 estimates are overly confident. Our results emphasize the importance of propagating uncertainties in all components of R0, including the shape of the generation-interval distribution, in efforts to estimate R0 at the outset of an epidemic. |
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Parzy, G, Daviet, et al |
Crit Care Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The main objective of the study was to determine the prevalence of venous thromboembolism events in patients infected
with severe acute respiratory syndrome coronavirus 2 requiring venovenous extracorporeal membrane oxygenation. DESIGN: Retrospective observational analysis at a single center. SETTING: Tertiary referral university teaching hospital. PATIENTS: Patients with
severe acute respiratory syndrome coronavirus 2-related severe acute respiratory distress syndrome requiring venovenous extracorporeal membrane oxygenation therapy with an injected CT scan performed after extracorporeal membrane oxygenation retrieval. RESULTS:
RESULTS: We included 13 severe acute respiratory syndrome coronavirus 2 patients requiring venovenous extracorporeal membrane oxygenation. All of these patients experienced venous thromboembolism: 10 patients (76.9%) had isolated cannula-associated deep vein
thrombosis, two patients (15.4%) had isolated pulmonary embolism, and one patient (7.7%) had both cannula-associated deep vein thrombosis and pulmonary embolism. |
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Patel, NM, Khajuria, et al |
Ann Med Surg (Lond) |
Healthcare Response | Réponse des soins de santé |
This cross-sectional study evaluated the usefulness of a webinar to educate trainees on CST selection in the UK. Most
attendees were in Foundation Year 2 (38.7%) and many had not previously attended a webinar as part of CST application preparation (93.7%). Over half of respondents (55.0%) preferred a webinar over a face-to-face tutorial, appreciating the flexibility, convenience
and zero financial cost associated. Many candidates received minimal advice on CST application by their Foundation School (47.7%) and 50.5% of respondents rated their confidence on the application process at '3 out of 5.' |
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Non-permissive SARS-CoV-2 infection of neural cells
in the developing human brain and neurospheres |
Pedrosa, CarolinadaSG, Goto-Silva, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, we investigate the presence of SARS-CoV-2 in the brain from an infant patient deceased from COVID-19. The susceptibility
to virus infection was compatible with the expression levels of viral receptor ACE2, which is increased in the ChP in comparison to other brain areas. To better comprehend the dynamics of the viral infection in neural cells, we exposed human neurospheres to
SARS-CoV-2. Similarly to the human tissue, we found viral RNA in neurospheres, although viral particles in the culture supernatant were not infective. Based on our observations in vivo and in vitro, we hypothesize that SARS-CoV-2 does not generate productive
infection in developing neural cells and that infection of ChP weakens the blood-cerebrospinal fluid barrier allowing viruses, immune cells, and cytokines to access the CNS, causing neural damage in the young brain. |
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Usefulness of rectal ozonetherapy in a geriatric patient with severe COVID-19 pneumonia |
Peña-Lora, DY, Albaladejo-Florín, et al |
Revista Espanola de Geriatria y Gerontologia |
Clinical data| Données cliniques |
This case report described an 84-year-old woman admitted for a with a 10-day history of symptoms and diagnosed with
SARS-CoV-2. The patient had a lengthy medical history, including several comorbidities. The patient did not improve despite despite treatment according to the clinical guidelines. Rectal ozone therapy was administered and the patient improved. |
|
Peng, W, Xu, et al |
Arch Physiol Biochem |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique Healthcare Response | Réponse
des soins de santé |
This study used TCMSP, SwissTargetPrediction, SEA, GeneCards, CTD, and TTD to identify potential targets for matrine
in SARS-CoV-2. Ten common matrine targets were obtained, particularly including TNF-α, IL-6, and CASP3. GO and KEGG pathway enrichment analysis revealed five significantly enriched signalling pathways involved in cell proliferation, apoptosis, programmed cell
death, and immune responses. |
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Structures of the SARS-CoV-2 nucleocapsid and their perspectives for
drug design |
Peng, Y, Du, et al |
Embo j |
Coronavirology| Coronavirologie |
Nucleocapsid (N) protein, which is the major structural component of the virion and is involved in viral replication,
assembly and immune regulation, plays key roles in the viral life cycle. Here, we solved the crystal structures of the N- and C-terminal domains (N-NTD and N-CTD) of SARS-CoV-2 N protein, at 1.8 and 1.5 Å resolution, respectively. Both structures show conserved
features from other CoV N proteins. The binding sites targeted by small molecules against HCoV-OC43 and MERS-CoV, which inhibit viral infection by blocking the RNA-binding activity or normal oligomerization of N protein, are relatively conserved in our structure,
indicating N protein is a promising drug target. In addition, certain areas of N-NTD and N-CTD display distinct charge distribution patterns in SARS-CoV-2, which may alter the RNA-binding modes. |
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Perlman, Y, Yechiali, et al |
Safety Science |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique |
In this paper, we construct and analyze two special nonclassical multi-server queueing models to control queueing problems
generated by social distancing constraints associated with the COVID-19 pandemic such as “Maximum shoppers at store” and “maximum number of customers in checkout area.” In the first model, store’ management chooses the number of cashiers to provide to minimize
its operational costs and its customers’ implied waiting costs based on the number allowed in the store. In the second model, the store partitions its total space into two separate areas – one for shoppers and one for the cashiers and payers – to increase
cashiers’ safety. For each model, we derive and analyze the equilibrium strategies in terms of the store’s customer capacity and the number of cashiers. |
|
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Peros, G, Gronki, et al |
Emerg Microbes Infect |
Healthcare Response | Réponse des soins de santé |
We describe the organizational process in setting up a coronavirus disease 2019 triage unit in a Swiss tertiary care
hospital. Methods: Our triage unit was set-up outside of the main hospital building and consists of three areas: 1. Pre-triage, 2. Triage, and 3. Triage plus. The Pre-triage check-points identify any potential COVID-19-infected patients and re-direct them
to the main Triage area where trained medical staff screen which patients undergo diagnostic testing. If testing is indicated, nasopharyngeal swabs are performed. If patients require further investigations, they are referred to Triage plus. Observations:
A total of 1265 patients were screened between 10 March 2020 and 12 April 2020 at our Triage unit. Of these, 112 (8.9%) tested positive. |
|
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The Deployment and Operation of Outdoor Treatment Tents During the COVID-19 Pandemic |
Peterson, KHJ, Muckey, et al |
Disaster Med Public Health Prep |
Healthcare Response | Réponse des soins de santé |
In order to prepare for the inevitable patient surge, one hospital set up outdoor triage tents to assist with increased
volume. Using the paradigm of space, staff, and stuff, an outdoor treatment area was designed and placed into operation. The patient volume in the treatment tents quickly grew with a one-day max volume of 88 patients. Through the end of May 2020, 2,473 patients
were seen and evaluated. As COVID-19 continues to spread and new areas of the United States and the world see spikes, it is imperative for the hospitals that previously dealt with a surge to disseminate the best practices they have learned during the pandemic. |
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A QUALITATIVE STUDY on MENTAL DISTRESS of VIETNAMESE STUDENTS in the U.S.A. In the
COVID-19 ERA |
Pham, NC, Shi, et al |
Asia Pacific Journal of Health Management |
Public Health response| Interventions de santé publique |
This paper aims to examine how the COVID-19 pandemic affects the mental distress of the Vietnamese students in the
USA. This research includes the interviews of 20 Vietnamese students in the USA during the COVID-19 era. The textual analysis showed that the mental distress of these Vietnamese students were caused by limited access to on-campus facilities and activities,
limited access to public services including grocery shopping, transportations, clinics, the possibility of being infected, isolated living condition due to the lockdown order, and inability to go back to the home country when wanted. We found that both physical
attributes (e.g., living condition, internet difficulty, overwhelmed healthcare system, restricted traveling, lack of personal interaction, limited access to public services) and psychological factors (e.g., anxiety of unfamiliar teaching modality, fear of
viral infection, uncertain career aspects, cultural barrier and prejudice) directly led to the mental distress of these students. Moreover, other factors such as turbulent future job markets and potential racism toward Asians in relation with “Chinese virus”
may cause the mental distress of these students. |
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Relationship quality and mental health during COVID-19 lockdown |
Pieh, C, T, et al |
PLoS One |
Public Health response| Interventions de santé publique |
This study evaluated differences in several mental health and well-being measures according to relationship quality
during the Coronavirus Disease (COVID-19) pandemic and related lockdown measures. A cross-sectional online survey was launched four weeks after lockdown measures were implemented in Austria. Relationship quality was measured with the Quality of Marriage Index
(QMI), and mental health measures included quality of life (WHO-QOL BREF psychological domain), well-being (WHO-5), depression (PHQ-9), anxiety (GAD-7), stress (PSS-10), and sleep quality (ISI). . In all mental health scales, individuals with good relationship
quality (n = 543) scored better than individuals with poor relationship quality (n = 190) or without relationship (n = 272). The odds ratios (OR) between the poor and good relationship quality groups were 3.5 for the PHQ-9, 3.4 for the GAD-7, and 2.0 for the
ISI. Additionally, individuals without no relationship scored better on all scales than individuals with poor relationship quality (all p-values < .05). Relationship quality was related to mental health during COVID-19. The prevalence of depressive symptoms
increased according to relationship quality from 13% up to 35%. Relationship per se was not associated with better mental health, but the quality of the relationship was essential. Compared to no relationship, a good relationship quality was a protective factor
whereas a poor relationship quality was a risk factor. |
|
Pizzi, R, Gini, et al |
Thrombosis research |
Clinical data| Données cliniques |
Aimed to compare coagulation parameters on admission between COVID-19 patients and non-COVID-19 patients with acute
respiratory insufficiency and to describe VTE diagnosed at entry. In this single-centre, observational retrospective study consecutive patients admitted for fever and acute respiratory failure were included. Of 324 patients, 50% had COVID-19. D-dimer was increased
in 86.5% COVID19 patients and in 84.9% non-COVID19 patients; mean values were similar (2185 ng/mL and 2814 ng/mL, respectively, p = n.s.) D-dimer levels were similarly increased in patients with and without SARS-CoV 2 related disease. |
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Popofsky, S, Noor, et al |
Journal of Pediatrics |
Public Health response| Interventions de santé publique |
Of the 160 mother–newborn dyads, 103 mothers were reached by telephone, and 85 consented to participate. There was
no significant difference in the predelivery feeding plan between the separated and unseparated dyads (P =.268). Higher rates of breastfeeding were observed in the unseparated dyads compared with the separated dyads both in the hospital (P <.001) and at home
(P =.012). Only 2 mothers in each group reported expressed breast milk as the hospital feeding source (5.6% of unseparated vs 4.1% of separated). COVID-19 was more commonly cited as the reason for change in the separated group (49.0% vs 16.7%; P <.001). When
the dyads were further stratified by symptom status into 4 groups—asymptomatic separated, asymptomatic unseparated, symptomatic separated, and symptomatic unseparated—the results remained unchanged. |
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32771645; Thermal treatment of nasopharyngeal samples before cobas SARS-CoV-2 testing |
Pryce, TM, Boan, et al |
Clinical Microbiology and Infection |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Thermal inactivation evaluation: Following implementation of cobas SARS-CoV-2 testing (Roche, Basel, Switzerland),
we encountered shortages of GuHCl and personal protective equipment. As a result of safety concerns and suboptimal recovery of SARS-CoV-2 from culture, our laboratory did not confirm the inactivation efficacy of thermal treatment. However, using standard
biosafety level 2 (BSL2) laboratory safety procedures, we continue to use the highest temperature assessed with a time that suits the work flow (75°C for 15 minutes), thereby exceeding a previously published temperature and duration of 70°C for 5 minutes for
complete SARS-CoV-2 inactivation in virus transport medium |
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Construction and validation of UV-C decontamination cabinets for filtering facepiece respirators |
Purschke, M, Elsamaloty, et al |
Applied Optics |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
We present evidence-based design principles for three different UV-C based decontamination systems for N95 filtering
facepiece respirators (FFRs) within the context of the SARS-CoV-2 outbreak of 2019–2020. The approaches used here were created with consideration for the needs of low- and middle-income countries (LMICs) and other under-resourced facilities. As such, a particular
emphasis is placed on providing cost-effective solutions that can be implemented in short order using generally available components and subsystems. We discuss three optical designs for decontamination chambers, describe experiments verifying design parameters,
validate the efficacy of the decontamination for two commonly used N95 FFRs (3M, #1860 and Gerson #1730), and run mechanical and filtration tests that support FFR reuse for at least five decontamination cycles. © 2020 Optical Society of America |
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Qureshi, AI, Huang, et al |
Accident Analysis and Prevention |
Public Health response| Interventions de santé publique |
This study examined the effect of mandated societal lockdown to reduce the transmission of coronavirus disease 2019
(COVID-19) on road traffic accidents. found that there was a significant reduction in road traffic accidents resulting in minor or no injuries (mean 14.5 versus 10.8, p < 0.0001) but not in accidents resulting in serious or fatal injuries (mean 3.4 versus
3.7, p = 0.42) after mandated societal lockdown. Furthermore, there was a significant reduction in road traffic accidents resulting in minor or no injuries after the mandated social lockdown (parameter estimate -5.9, p = 0.0028) in the time series analysis.
There was an increase in road traffic accidents resulting in minor or no injuries after expiration of mandatory societal lockdown (mean 10.8 versus 13.7, p = 0.04). |
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Radermecker, C, Detrembleur, et al |
J Exp Med |
Clinical data| Données cliniques |
Here we analyzed postmortem lung specimens from four patients who succumbed to COVID-19 and four patients who died
from a COVID-19–unrelated cause. We report the presence of Neutrophil extracellular traps (NETs) in the lungs of each COVID-19 patient. NETs were found in the airway compartment and neutrophil-rich inflammatory areas of the interstitium, while NET-prone primed
neutrophils were present in arteriolar microthrombi. Our results support the hypothesis that NETs may represent drivers of severe pulmonary complications of COVID-19 and suggest that NET-targeting approaches could be considered for the treatment of uncontrolled
tissue-damaging and thrombotic responses in COVID-19. |
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Rahman, F, Liu, et al |
Clin Transplant |
Clinical data| Données cliniques Therapeutics| Thérapeutique |
Convalescent plasma was administered to hospitalized patients with coronavirus disease 2019 (COVID-19) at an academic
transplant center in New York City. The median time from symptom onset to plasma infusion was 8 days. Eight of 13 patients (62%) had de-escalating oxygenation support by day 7 post-convalescent plasma. Nine (69%) patients were discharged, 1 (7%) patients
remain hospitalized and 3 (23%) patients died. This series supports the need for additional studies on convalescent plasma use in SOT recipients with COVID-19 to better determine efficacy and identify patients who are likely to benefit. |
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Rahman, SMM, Kim, et al |
Resources, Conservation and Recycling |
Economics | Économie |
The sustainability of the ship recycling industry strongly linked with the global shipping market and international
commodity flows. Our estimate suggests that about 300 million Gross Tonnage (GT) available for demolition in the next five years and the inability to get them recycled would cost about 20 billion dollars and the loss of many employment oppourtunities. In
this study, we apply a scenario analysis technique to understand the impact range of COVID-19 in the short term and in the long term. |
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Rajagopal, K, Varakumar, et al |
International Journal of Research in Pharmaceutical Sciences |
Coronavirology| Coronavirologie |
In the present article, in-silico studies have been performed to explore the binding modes of Thiazine substituted
9-anilinoacridines (1a-z) against SARS CoV 2 main protease (PDB id-5R82) targeting the coronavirus using Schrodinger suit 2019-4. The molecular docking studies are performed by Glide module, in-silico ADMET screening was performed by Qik prop module, and the
binding free energy of ligands was calculated using PRIME MM-GB/SA module of Schrodinger suite 2019-4, Maestro 21.2 version. From the in-silico results, Thiazine substituted 9-anilinoacridines like 1m, 1j, 1s and 1b are significantly active against SARS CoV
2 main protease with Glide score more than-5.4 when compared with the currently recommended drug for COVID19, Hydroxychloroquine (G score-5.47). The docking results of the Thiazine substituted 9-anilinoacridines exhibited similar mode of interactions with
COVID19 and the residues GLN19, THR24, THR25, THR26, LEU27, HIE41, SER46, MET49, ASN142, GLN143, HIE164, MET165, ASP187, ARG188 and GLN189, play a crucial role in binding with ligands. |
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COVID-19 in systemic lupus erythematosus: data from a survey on 417 patients |
Ramirez, GA, Gerosa, et al |
Seminars in arthritis and rheumatism |
Epidemiology| Épidémiologie Clinical data| Données cliniques Public Health response|
Interventions de santé publique |
The objective of this study was to acquire information on the impact of COVID-19 in systemic lupus erthyematosus (SLE)
patients. The results of this study suggest that during this time, at least 1.2% of patients with SLE had confirmed COVID-19. An additional nine subjects in our cohort were diagnosed with presumed COVID-19 rising this estimation to 3.4%. Changes in daily habits,
coping measures, and treatments during the pandemic were also acquired via questionnaire. Fever, anosmia, dry cough, a self-reported history of neuropsychiatric SLE and a recent contact with confirmed COVID-19 cases were more strongly associated with COVID-19,
as were symptoms and lower compliance to behavioural preventive measures in patients’ contacts. No protective effect was seen in subjects on hydroxychloroquine. |
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Medicine and surgery residents' perspectives on the impact of COVID-19 on graduate
medical education |
Rana, T, Hackett, et al |
Med Educ Online |
Healthcare Response | Réponse des soins de santé |
Our study aimed to analyze the effects of COVID-19 crisis-related stressors on medical residents’ professional and
personal lives. The primary outcome was to determine which factors or resident characteristics were related to stress during the pandemic. Our secondary goals were to examine which resident characteristics were related to survey responses. Anxiety about PPE
(P < 0.001), female gender (P = 0.03), and the interaction between female gender and anxiety about PPE (P = 0.04) were significantly related to increased stress during the COVID-19 pandemic. |
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Rao, Shilpa, Hoskins, et al |
bioRxiv |
Coronavirology| Coronavirologie |
Here, using a novel FACS-based assay called MeTAFlow, we report a dose-dependent reduction in both nascent protein
synthesis and mRNA abundance in cells expressing NSP1. We perform RNA-Seq and matched ribosome profiling experiments to identify gene-specific changes both at the mRNA expression and translation level. We discover a functionally-coherent subset of human genes
preferentially translated in the context of NSP1 expression. These genes include the translation machinery components, RNA binding proteins, and others important for viral pathogenicity. Importantly, we also uncover potential mechanisms of preferential translation
through the presence of shared sites for specific RNA binding proteins and a remarkable enrichment for 5′ terminal oligo-pyrimidine tracts. Collectively, the present study suggests fine tuning of host gene expression and translation by NSP1 despite its global
repressive effect on host protein synthesis. |
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Raval, B, Srivastav, et al |
J Biomol Struct Dyn |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI) |
Our work investigates the interaction of synthesized graphene with the SARS-CoV-2 virus using molecular docking and
molecular dynamics (MD) simulation method. he binding energy of graphene towards the virus increased with an increasing number of layers. It shows the highest affinity of −17.5 Kcal/mol in molecular docking while ΔGbinding is in the order of −28.01 ± 0.04
5 Kcal/mol for the seven-layers structure. The increase in carbon layers is associated with an increasing number of edge sp3 –type carbon, providing greater curvature, further increase the surface reactivity responsible for high binding efficiency. The MD
simulation data reveals the high inhibition efficiency of the synthesized graphene towards SARS-CoV-2 virus which would help to design future in-vitro studies. The graphene system could find potential applications in personal protective equipment and diagnostic
kits. |
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SARS-CoV-2 Infection in Cancer Patients: A Picture of an Italian Onco-Covid Unit |
Reale, ML, Bironzo, et al |
Frontiers in Oncology |
Clinical data| Données cliniques |
In this monocentric retrospective study we included all SARS-CoV-2 oncological patients accepted, between March 27th
and April 19th 2020, at the Onco-COVID Unit at San Luigi Gonzaga Hospital, one of the few Italian oncological-COVID wards. Eighteen cancer patients with COVID-19 were included. The mean (±SD) age of patients was 67 ± 14 years, 89% were men. Seven (39%) developed
infection in communities and 11 (61%) during hospitalization. Lung cancer was the most frequent type of cancer (10, 56%). Seven patients (39%) were symptomatic for COVID-19 at the time of diagnosis and symptoms began 2 (±2) days before. The most common were
shortness of breath and diarrhea. Fever was present in 5 patients (28%). Among the 11 asymptomatic patients, 8 (73%) became symptomatic during the hospitalization (mean time of symptoms onset 4 days ±4). Six patients (33%) were on active anti-tumor treatment:
2 (33%) received anti-tumor therapy within 2 weeks before the infection diagnosis and 2 (33%) continued oncological treatment after SARS-CoV-2 positivity. Eight (44%) patients died within a mean of 12 days (±8) from the infection diagnosis. |
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Reed, S, Gonzalez, et al |
Value in Health |
Public Health response| Interventions de santé publique |
Objective: To conduct a discrete-choice experiment to quantify Americans’ acceptance of severe acute respiratory syndrome
coronavirus 2 infection risks for earlier lifting of social-distancing restrictions and diminishing the pandemic's economic impact. |
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Sehverlust
nach assistierter mechanischer Beatmung aufgrund von SARS-CoV-2 - Eine Fallserie |
Reich, M, Pauleikhoff, et al |
Deutsches Arzteblatt International |
Clinical data| Données cliniques |
case serie of neuroretinal damage in three patients after assisted mechanical ventilation due to SARS-CoV-2. |
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Reilly, E, Skeoch, et al |
Clin Med (Lond) |
Public Health response| Interventions de santé publique |
The logistical challenges of rapidly and accurately identifying those patients who needed to shield during the COVID-19
pandemic were unprecedented. We report our experiences of meeting this challenge for >9,000 patients with rheumatic and musculoskeletal disease at our centre, incorporating an element of guided patient self-stratification. Our results indicate that patients
are able to stratify their own risk accurately using the BSR COVID-19 risk stratification guidance. |
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Knowledge and awareness on the impact of covid-19 on global wealth-a survey |
Rieshy, V, Gayatri Devi, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
The main aim of this study is to evaluate the awareness level of global wealth due to covid 19. A self-designed survey
study was conducted among 100 individuals of the general population. The questionnaire was designed in the manner to assess their knowledge about the impact of COVID-19 on global wealth. The responses recorded in the present study from the survey participant
depicts that the participants possess adequate knowledge about the COVID-19 infection and equally they possess an adequate awareness about the impact caused globally due to COVID-19. The results of the present study shows that 71.03% of the participants are
aware about the pandemic outbreak COVID-19 and among them 57.94% participants believes that the pandemic outbreak COVID-19 resulted in a global impact on various industries. |
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Rijkers, G, Murk, et al |
J Infect Dis |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
We determined and compared the humoral immune response in patients with severe (hospitalized) and mild (nonhospitalized)
coronavirus disease 2019 (COVID-19). Patients with severe disease (n = 38) develop a robust antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including immunoglobulin G and immunoglobulin A antibodies. The geometric mean 50%
virus neutralization titer is 1:240. SARS-CoV-2 infection was found in hospital personnel (n = 24), who developed mild symptoms necessitating leave of absence and self-isolation, but not hospitalization; 75% developed antibodies, but with low/absent virus
neutralization (60% with titers <1:20). While severe COVID-19 patients develop a strong antibody response, mild SARS-CoV-2 infections induce a modest antibody response. |
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Rivera-Hernandez, P, Nair, et al |
AJP Reports |
Transmission Clinical data| Données cliniques |
Based on scant available data, vertical transmission is considered unlikely. This case report presents a preterm neonate
born to a critically ill mother with SARV-CoV-2 with early evidence of infection with a positive reverse transcription polymerase chain reaction on day 1. Lack of parental contact prior to testing and strict adherence to recommended airborne precautions perinatally
suggest vertical transmission of infection. Critical maternal illness and medications may have contributed to the need for extensive resuscitation at birth and highlight the importance of close fetal monitoring. Infant lacked immunoglobulin G antibody response
by 3 weeks, presumably secondary to mild clinical course and prematurity. Effects of SARS-CoV-2 in preterm infants, their antibody response and potential for asymptomatic carriage remain uncertain. |
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Roehrig, S, Ait Hssain, et al |
Trials |
RCT |
This study aims to demonstrate the positive effects on oxygenation of flow-controlled ventilation compared to conventionally
ventilated patients in patients suffering from Acute respiratory distress syndrome (ARDS) associated with COVID-19. The protocol was registered before starting subject recruitment under the title: "Flow controlled ventilation in ARDS associated with COVID-19"
in ClinicalTrials.org with the registration number: NCT04399317. |
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Who's in and Who's Out Under Workplace COVID Symptom Screening? |
Ruffini, Krista, Sojourner, et al |
SSRN- Lancet prepublication |
Public health interventions*| Interventions de santé publique |
COVID symptom screening, a new workplace practice, is likely to affect many millions of American workers in the coming
months. This paper provides some of the first empirical work exploring the tradeoffs employers face in using daily symptom screening. First, we find that common symptom checkers will likely screen out up to 7 percent of workers each day, depending on the measure
used. Second, we find that the measures used will matter for three reasons: many respondents report any given symptom, survey design affects responses, and demographic groups report symptoms at different rates, even absent fluctuations in likely COVID exposure. |
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Rumpler, R, Venkataraman, et al |
Sustain Cities Soc |
Public Health response| Interventions de santé publique |
While several governments have imposed a nationwide total or partial lockdown in order to slow down the spread of the
virus, the Swedish government has opted for a recommendation-based approach together with a few imposed restrictions. In the present contribution, the impact of this strategy will be observed through the monitored variation of the city noise levels during
the associated period. The noise level reductions, observed during the period of restrictions, are shown to be comparable to those found for the two most popular public holidays in Sweden with a peak reduction occurring during the first half of April 2020.
Contrary to what has been recently discussed in public media, the spread of the virus, the recommendations, and the restrictions imposed during the ongoing pandemic clearly have had a significant effect on the transport and other human-related activities in
Stockholm. |
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Th17 and Treg cells function in SARS-CoV2 patients compared with healthy controls |
Sadeghi, A, Tahmasebi, et al |
J Cell Physiol |
Clinical data| Données cliniques |
The current study aimed to evaluate the responses of Th17 and Treg cells in COVID‐19 patients compared with the control
group. The findings showed that enhanced responses of Th17 cells and decreased responses of Treg cells in 2019‐n‐CoV patients compared with controls had a strong relationship with hyperinflammation, lung damage, and disease pathogenesis. Also, the high ratio
of Th17/Treg cells and their associated factors in COVID‐19‐dead patients compared with improved cases indicates the critical role of inflammation in the mortality of patients. |
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Sadiković, S, Branovački, et al |
Frontiers in Psychology |
Public Health response| Interventions de santé publique |
This research was conducted in order to examine and further our understanding of emotional reactions to the ongoing
pandemic. |
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Saha, I, Ghosh, et al |
Infection, Genetics and Evolution |
Coronavirology| Coronavirologie |
Authors analyze 566 Indian SARS-CoV-2 sequences using multiple sequence alignment techniques viz. ClustalW, MUSCLE,
ClustalO and MAFFT to align and subsequently identify the lists of mutations as substitution, deletion, insertion and SNP. |
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Şahin, MK, Aker, et al |
J Community Health |
Healthcare Response | Réponse des soins de santé |
This study evaluated the prevalence of depression, anxiety, distress, and insomnia and related factors in healthcare
workers during the COVID-19 pandemic in Turkey. CWs serving in Turkey during the COVID-19 pandemic experienced high levels of depression, anxiety, insomnia, and distress symptoms. Female gender, being a nurse, working on the front line, history of psychiatric
illness, and being tested for COVID-19 were identified as risk factors for mental health problems. |
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Sahin, S, Calapoğlu, et al |
Biointerface Research in Applied Chemistry |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
The present work aimed to assess the inhibition potential of Didemnin A, B, and C isolated from tunicates to COVID-19
Mpro protein through a molecular docking method. The molecular characterization of compounds with binding affinity was performed by using the Swiss Target Prediction Method. As a result, the binding energy of Didemnins A, B, and C was calculated as-11.82 kcal/
mol,-10.27 kcal/ mol, and-9.26 kcal/ mol, respectively. Also, the docking studies showed that Didemnin B involved in hydrogen bonding with Glu166 in the active site of the Mpro protein. Therefore, the natural marine compounds have the potential for developing
drugs against to SARS-CoV-2 virus, which may aid in overcoming the clinical challenge of the COVID-19 pandemic. |
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Sakamaki, I, Morinaga, et al |
Journal of Infection and Chemotherapy |
Clinical data| Données cliniques |
A 54-year-old man was admitted on day 6 of onset with a chief complaint of high fever and cough. Computed tomography
(CT) showed a ground glass opacity in both lungs, and reverse transcription-polymerase chain reaction (RT-PCR) diagnosed COVID-19. He was admitted to the hospital and started to receive oxygen and favipiravir. After that, his respiratory condition deteriorated,
and he was intubated and ventilated on day 9 of onset, and extracorporeal membranous oxygenation (ECMO)was introduced on day 12. Two days after the introduction of ECMO, C-reactive protein (CRP) increased, chest X-p showed no improvement in pneumonia, and
PaO2/FiO2 decreased again. As D-dimer rose and found a blood clot in the ECMO circuit, we had to decide whether to replace the circuit and continue with ECMO or stop ECMO. At this time, the viral load by RT-PCR was drastically reduced to about 1/1750. We decided
to continue ECMO therapy and replaced the circuit. The patient's respiratory status subsequently improved and ECMO was stopped on day 21 of onset. |
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Relational Mobility Predicts Faster Spread of COVID-19: A 39-Country Study |
Salvador, CE, Berg, et al |
Psychol Sci |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
It stands to reason that the spread of the virus depends on sociocultural ecologies that facilitate or inhibit social
contact. In particular, the community-level tendency to engage with strangers and freely choose friends, called relational mobility, creates increased opportunities to interact with a larger and more variable range of other people. It may therefore be associated
with a faster spread of infectious diseases, including COVID-19. Here, we tested this possibility by analyzing growth curves of confirmed cases of and deaths due to COVID-19 in the first 30 days of the outbreaks in 39 countries. We found that growth was significantly
accelerated as a function of a country-wise measure of relational mobility. This relationship was robust either with or without a set of control variables, including demographic variables, reporting bias, testing availability, and cultural dimensions of individualism,
tightness, and government efficiency. Policy implications are also discussed. |
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Sanchez-Larsen, A, Gonzalez-Villar, et al |
Epilepsy and Behavior |
Public Health response| Interventions de santé publique Healthcare Response | Réponse
des soins de santé |
The aim of this study was to have a better understanding of the influence of the coronavirus disease 2019 (COVID-19)
pandemic in people with epilepsy (PWE) and to assess whether there have been changes in seizure control during the current COVID-19 outbreak, exploring the possible causes thereof. Methods: This is an observational, retrospective study based on prospective
data collection of 100 successive patients who attended an epilepsy outpatient clinic either face-to-face or telephonically during the months of the COVID-19 outbreak and national state of emergency. Results: Conclusions: A high proportion of PWE suffered
a significant worsening of their seizure control during the months of the COVID-19 pandemic. Emotional distress due to home confinement was the main factor for the change in seizure control. Promoting physical activity and adequate sleep may minimize the potential
impact of the pandemic in PWE. Ensuring correct follow-up can prevent decompensation in those PWE at high risk. |
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COVID-19
in older adults: Retrospective cohort study in a tertiary hospital in Japan |
Sano, T, Kimizuka, et al |
Geriatr Gerontol Int |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Authors aimed to describe the clinical characteristics, treatment and outcomes of patients with COVID-19 pneumonia,
in particular older patients, admitted to tertiary and partner hospitals in Saitama, Japan. In older patients, typical clinical symptoms and blood test changes were often absent; however, CT always contained typical findings of COVID-19, suggesting that CT
may be a useful diagnostic tool. |
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Santonicola, A, Zingone, et al |
Clinics and Research in Hepatology and Gastroenterology |
Healthcare Response | Réponse des soins de santé |
We aimed to investigate in a cohort of LT recipients the access to remote consultation and the attitude towards Telemedicine
using an internet-based survey. Seventy-four/one hundred and fifty-three (48.3%) LT recipients were unable to access remote consultation. They showed a significantly higher mean age and a higher percentage of low school degree compared to those who accessed
it (p = 0.03 and p = 0.001, respectively). Among the remaining LT recipients, 50/79 (63.3%) responded to the survey; mean time from liver transplantation was 12 ± 7 years; 94% of the sample reported at least one comorbidity; 44% of LT recipients declared to
be “very much/much” worried because of COVID-19 infection, and 64% considered themselves more vulnerable than the general population. Forty percent of responders refused the routine follow-up visit, and 62% were very interested in using Telemedicin |
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Sasere, OB, Makhasane, et al |
International Journal of Higher Education |
Public Health response| Interventions de santé publique |
This study investigated the effectiveness of virtual programme delivery and assessment in Higher Education Institutions
(HEIs) during the COVID-19 (Corona Virus) pandemic, from a global perspective. The study assesses the success rate of virtual teaching and learning via various online platforms that were set up to make up for time lost due to the unanticipated global HEIs
closure. The findings revealed disparities in responses to virtual learning across HEIs and national contexts. Training and re-training of lecturers and students, and the provision of virtual learning enabling infrastructure, were recommended to mitigate similar
situation in future. |
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Heavy exposure of children aged 9 to 12 years
with SARS-CoV-2 did not lead to infection |
Schmidt, E, Steinhagen, et al |
J Pediatric Infect Dis Soc |
Clinical data| Données cliniques |
Here, we report on four school children with heavy exposure to SARS-CoV-2 with no clinical signs of COVID-19, repeated
negative nasopharyngeal swabs for SARS-CoV-2 RNA, and no seroconversion. |
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New-Onset Nephrotic Syndrome in a Child Associated With COVID-19 Infection |
Shah, SA, Carter, et al |
Frontiers in Pediatrics |
Clinical data| Données cliniques |
Authors describe a case report of a child with new-onset nephrotic syndrome associated with COVID-19 infection.
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Shahdad, S, Patel, et al |
Br Dent J |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
This study aimed to investigate the efficacy of a commercially available extraoral scavengers(EOS) device on contamination
reduction during dental aerosol generating procedures (AGPs). The secondary aim was to investigate differences between open and closed dental operatories. Dental procedures were simulated on a dental manikin using citric acid (10%) added to the water lines
with universal indicating paper (UIP) placed in strategic locations in the operatory, on the clinician and assistant. Chromatic change related to settling of splatter containing citric acid on the UIP was analysed to calculate percentage intensity of splatter
contamination. EOSs resulted in 20% reduction in frequency and 75% reduction in mean intensity of contamination of operatory sites. There was a 33% and 76% reduction in mean intensity contamination for clinician and assistant, respectively. Use of rubber dam
and four-handed dentistry resulted in further reduction. |
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Shahinshavali, S, Hossain, et al |
Tetrahedron letters |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
In silico studies were performed using 3-alkynyl 2-chloroquinoxalines. These compounds were assessed as ligands for
N-protein of SARS-CoV-2. Their synthesis involved Cu-catalyzed coupling under ultrasound irradiation. In silico studies established a virtual SAR within the series. Three compounds appeared as potential agents for further studies. |
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Sheikh, MK, Malavde, et al |
International Journal of Current Research and Review |
Public Health response| Interventions de santé publique |
Extensive viewing of the computer screen can lead to eye discomfort, fatigue, blurred vision and headaches, dry eyes
and other symptoms of eyestrain. 44 school-aged children attending online classes in the age group 6 to 15 years were included. Eye fatigue was assessed through the 7-point Likert Scale before the exercise session. A significant reduction was seen in eye
fatigue with self-relaxing yogic eye exercises followed by the ergonomic advice in school-aged children attending online classes in COVID-19. |
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Shekhar, R, Sheikh, et al |
Journal of Stroke and Cerebrovascular Diseases |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Objective: To study the central nervous system (CNS) complications in patients with COVID-19 infection especially among
Native American population in the current pandemic of severe acute respiratory syndrome virus (COVID-19). Total of 90 hospitalized patients were screened. Out of seven patients, majority were Native Americans females, and developed neurological complications
including subarachnoid hemorrhage (SAH), Intraparenchymal hemorrhage (IPH), Ischemic stroke (IS) and seizure. All 7 patients required Intensive care unit (ICU) level of care. Patients who developed CNS complications other than seizure were females in the younger
age group (4 patients, 38-58 years) with poor outcome. Out of 7, three developed subarachnoid hemorrhage, two developed ischemic infarction, and four developed seizure. Two patients with hemorrhagic complication expired during the course of hospitalization.
All three patients with seizure were discharged to home |
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Shen, L, Zhao, et al |
Science of the Total Environment |
Public health interventions*| Interventions de santé publique |
We assess the extent of wintertime aerosol changes over Central-Eastern China during the city lockdown for COVID-19.
The aerosol optical depth and Angstrom exponent during the COVID-19 lockdown decreased and increased, respectively, in most regions. The long-range transport of air pollutants substantially contributed to PM2.5 pollution in Hubei. |
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Efficient high-throughput SARS-CoV-2 testing to detect asymptomatic carriers |
Shental, N, Levy, et al |
Sci Adv |
Epidemiology| Épidémiologie Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We developed P-BEST, a method for Pooling-Based Efficient SARS-CoV-2 Testing, which identifies all positive subjects
within a set of samples using a single round of testing. We pooled sets of 384 samples into 48 pools, providing both an eightfold increase in testing efficiency and an eightfold reduction in test costs, while identifying up to five positive carriers. We then
used P-BEST to screen a cohort of 1115 health care workers in Israel. All of the pools tested were negative. |
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Impact of returning population migration after the Chinese Spring Festival on the COVID-19
epidemic |
Shi, Y, Cheng, et al |
Kexue Tongbao/Chinese Science Bulletin |
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique Public Health response| Interventions de santé publique |
In this study, we use the discrete stochastic model (DSM) to study the transmission dynamics of COVID-19. As long as
the epidemic situation in different regions is distinguished, return trips could be arranged at reduced people density, attentive epidemic prevention of transportation, and well preparation at the receiving cities. Although, the possibility of an epidemic
rebound is small, only in conditions of slack thinking and strict measures are carried out. In accordance with the transmission of the world epidemic, more attention must be paid to the inspection of the influx of foreign infected people. |
|
Shields, A, Faustini, et al |
Thorax |
Epidemiology| Épidémiologie Immunology | Immunologie |
A cross-sectional study of asymptomatic healthcare workers undertaken on 24/25 April 2020 at University Hospitals Birmingham
NHS Foundation Trust (UHBFT), UK. 545 asymptomatic healthcare workers were recruited while at work. The point prevalence of SARS-CoV-2 viral carriage was 2.4% (n=13/545). The overall seroprevalence of SARS-CoV-2 antibodies was 24.4% (n=126/516). |
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Rapid implementation of a mobile prone team during the COVID-19 pandemic |
Short, B, Parekh, et al |
Journal of critical care |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
We describe the development of a mobile prone team during the height of the crisis in New York City and describe characteristics
and outcomes of mechanically ventilated patients who received prone positioning between April 2, 2020 and April 30, 2020. Ninety patients underwent prone positioning for moderate-to-severe ARDS. y the end of the study period, proning was discontinued in sixty-seven
(65.1%) cases due to clinical improvement, twenty (19.4%) cases due to lack of clinical improvement, six (5.8%) cases for clinical worsening, and ten (9.7%) cases due to a contraindication. |
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Prevalence of psychological effect of COVID-19 on medical professionals in a tertiary care
center |
Shrestha, SL |
Journal of the Nepal Medical Association |
Healthcare Response | Réponse des soins de santé |
. The objective of this study is to find the prevalence of anxiety among medical doctors and nurses. Out of 101 participants
prevalence of anxiety was found to be 74 (73.3%) (64.68-81.33 at 95% Confidence Interval). Among them, 9 (8.9%) of participants experienced sever types of generalized anxiety disorder, 23 (22.8%) moderate, and 42 (41.6%) mild type. Similarly, 18 (17.8%) and
10 (9.9%) of participants felt very difficult and extreme difficulty at the workplace and home respectively. |
|
Shu, Z, Zhou, et al |
Front Med |
Clinical data| Données cliniques |
We reported the clinical features and therapeutic characteristics of moderate COVID-19 cases in Wuhan that were treated
via the integration of traditional Chinese medicine (TCM) and Western medicine. A total of 293 COVID-19 inpatient cases, including 207 moderate and 86 (29.3%) severe cases, were included in our research. Among these cases, 238 were discharged, 31 were transferred,
and 24 (all severe cases) died in the hospital. Our COVID-19 cases involved elderly patients with advanced ages (57 years on average) and high comorbidity rates (61%). Our results reconfirmed several well-recognized risk factors, such as age, gender (male),
and comorbidities, as well as provided novel laboratory indications (e.g., cholesterol) and TCM-specific phenotype markers (e.g., dull tongue) that were relevant to COVID-19 infections and prognosis. In addition to antiviral/antibiotics and standard supportive
therapies, TCM herbal prescriptions incorporating 290 distinct herbs were used in 273 (93%) cases. The cases that received TCM treatment had lower death rates than those that did not receive TCM treatment (17/273 = 6.2% vs. 7/20= 35%, P = 0.0004 for all cases;
17/77= 22% vs. 7/9= 77.7%, P = 0.002 for severe cases). Lastly, 59% of the patients received treatment, including antiviral, antibiotics, and Chinese patent medicine, before admission. |
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Shuvo, SB, Molokwu, et al |
|
Modelling/ prediction| Modélisation/prédiction Public health interventions*| Interventions
de santé publique Healthcare Response | Réponse des soins de santé |
In this paper, the authors used artificial agent-based simulation modeling to identify the importance of social distancing
and hospitals' capacity in terms of the number of beds to shorten the length of an outbreak and reduce the total number of infections and deaths during an epidemic. After simulating the model based on different scenarios in a small artificial society, learned
that shorter social isolation activation delay has a higher impact on reducing the catastrophe. Increasing the hospital's treatment capacity, i.e., the number of isolation beds in the hospitals can become handy when social isolation cannot be activated shortly. |
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Siepmann, T, Sedghi, et al |
Eur J Neurol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We aimed to define the risk of acute stroke in patients with severe and non-severe COVID-19. METHODS: We performed
an observational multicenter cohort study in four participating hospitals in Saxony, Germany to characterize consecutive patients with laboratory-confirmed COVID-19 who experienced acute stroke during hospitalization. RESULTS: Of 165 patients hospitalized
for COVID-19 (49.1% males, median age 67 57-79], 72.1% severe or critical) included in the multicenter study, overall stroke rate was 4.2%. |
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Singh, P, Acharya, et al |
International Journal of Research in Pharmaceutical Sciences |
Healthcare Response | Réponse des soins de santé |
Here, we present our experience as a team at our Obstetrics and Gynaecology department of pregnant women with upper
respiratory tract infec-tion/suspected case of COVID-19 infection during hospitalization in our rural setup and further we will discuss patient triage based on risk level, antenatal care planning and handling emergencies during COVID-19 lockdown. |
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Slimani, Y, Abbassi, et al |
J Med Virol |
Clinical data| Données cliniques |
Here we present a case of systemic lupus erythematosus (SLE) with antiphospholipid antibody syndrome in a previously
healthy COVID‐19 patient, who subsequently developped a varicella‐like exanthem on the trunk. The disease resulted in death of the patient. The pathophysiological mechanisms resulting in overlapping disorders in our patient remain unknown, adding to the growing
mystery of this virus and raising questions about the nature of its link with cutaneous, autoimmune and autoinflammatory manifestations. Sharing the images of this case may benefit physicians dealing with similar patients during this pandemic. |
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Soleimani, A, Kazemian, et al |
Am J Hypertens |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This retrospective observational study investigated the association of ARBs with in-hospital outcomes of these patients.
In this cohort of 636 patients, 108 (17.0%) patients expired and 407 (64.0%) patients incurred severe COVID-19. Of 254 (39.9%) patients with hypertension, 122 (48.0%) patients were receiving an ARB. After adjustment for possible confounders, we found no independent
association between taking ARBs and in-hospital outcomes except for acute kidney injury (AKI), in patients with confirmed or clinically suspected COVID-19, either hypertensive or not-hypertensive. We found that discontinuation of ARBs during hospitalization
was associated with a greater risk of mortality, invasive ventilation, and AKI (All P˂0.002). |
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COVID-19 mortality dynamics: The future modelled as a (mixture of) past(s) |
Soubeyrand, S, Ribaud, et al |
PLoS One |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
Discrepancies in population structures, decision making, health systems and numerous other factors result in various
COVID-19-mortality dynamics at country scale, and make the forecast of deaths in a country under focus challenging. However, mortality dynamics of countries that are ahead of time implicitly include these factors and can be used as real-life competing predicting
models. We precisely propose such a data-driven approach implemented in a publicly available web app timely providing mortality curves comparisons and real-time short-term forecasts for about 100 countries. Here, the approach is applied to compare the mortality
trajectories of second-line and front-line European countries facing the COVID-19 epidemic wave. Using data up to mid-April, we show that the second-line countries generally followed relatively mild mortality curves rather than fast and severe ones. Thus,
the continuation, after mid-April, of the COVID-19 wave across Europe was likely to be mitigated and not as strong as it was in most of the front-line countries first impacted by the wave (this prediction is corroborated by posterior data). |
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Spinetti, T, Hirzel, et al |
Anesth Analg |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
As the role of immunosuppression in coronavirus disease 2019 (COVID-19) is currently unclear, this study explored the
level of monocytic human leukocyte antigen-DR (mHLA-DR) expression in COVID-19 patients. While normal mHLA-DR expression was observed in all hospitalized noncritically ill patients (n = 7), 89% (8 of 9) critically ill patients with COVID-19-induced acute
respiratory failure showed signs of downregulation of mHLA-DR at ICU admission. mHLA-DR expression at admission was significantly lower in critically ill patients (median, quartiles]: 9280 antibodies/cell 6114, 16,567]) as compared to the noncritically ill
patients (30,900 antibodies/cell 26,777, 52,251]), with a median difference of 21,508 antibodies/cell (95% confidence interval CI], 14,118-42,971), P = .002. Reduced mHLA-DR expression was observed to persist until day 5 after ICU admission. |
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A study on COVID-19 situation in Andhra Pradesh: Current scenario and projections |
Srinivasa Rao, D, Rajasekhar, et al |
International Journal of Current Research and Review |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
The purpose of this study is to assess the current status of COVID-19 in Andhra Pradesh and to forecast the condition
of future, which will help to strengthen management. Based on projected results, AP will cross 476534 cases by mid-September 2020. The proportion of positive cases out of tested samples in the state may go up to 30%. The COVID-19 death toll in the state may
cross the 5000 value. |
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Staunton, P, Gibbons, et al |
Surgeon |
Healthcare Response | Réponse des soins de santé |
This study investigates regional trauma patterns during the COVID-19 pandemic. The majority of trauma referred to our
Dublin based centre during COVID-19 related population restrictions appears to be home based and trauma volumes have decreased. Significant reductions are apparent in work and sport related injuries suggestive of compliance with COVID-19 activity guidelines. |
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Steinhardt, MJ, Wiebecke, et al |
Scand J Rheumatol |
Clinical data| Données cliniques |
We report the case of COVID-19 in a 48 year old male patient with pre-existing intermittent atrial fibrillation and
hypertension. On day 14 post symptom onset, we applied the first off-label dose of anakinra in an attempt to halt cytokine storm syndrome. Symptoms improved and the patient was released on day 31. |
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COVID-19 Infection Among Healthcare Workers: Serological Findings Supporting Routine
Testing |
Stock, AD, Bader, et al |
Frontiers in Medicine |
Epidemiology| Épidémiologie Clinical data| Données cliniques Immunology | Immunologie |
To determine the prevalence of asymptomatic SARS-CoV-2 infection amongst healthcare workers, we studied frontline staff
working in the Montefiore Health System in New York City. All participants were asymptomatic at the time of testing and were tested by RT-qPCR and for anti-SARS-CoV-2 antibodies. Of the 98 asymptomatic healthcare workers tested, 19 (19.4%) tested positive
by RT-qPCR and/or ELISA. Within this group, four (4.1%) were RT-qPCR positive, and four (4.1%) were PCR and IgG positive. Notably, an additional 11 (11.2%) individuals were IgG positive without a positive PCR. Two PCR positive individuals subsequently developed
COVID-19 symptoms, while all others remained asymptomatic at 2-week follow-up. These results indicate that there is considerable asymptomatic infection with SARS-CoV-2 within the healthcare workforce, despite current mitigation policies. |
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32702465; SARS-CoV-2 infection among healthcare workers in a hospital in Madrid,
Spain |
Suárez-García, I, Martínez de Aramayona López, et al |
Journal of Hospital Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques Healthcare Response |
Réponse des soins de santé |
The aim of this study was to describe the epidemiological and clinical characteristics of coronavirus disease 2019
(COVID-19) among HCWs from February 24th to April 30th, 2020, in a hospital in Madrid, Spain. Among 1911 HCWs, 213 (11.1%) had COVID-19 during the study period. The prevalence of comorbidities was low and 91.5% of patients had mild or moderate symptoms. Eleven
patients were admitted to the hospital and one patient needed intensive care. None of the patients died. The median time of sick leave was 20 (interquartile range: 15–26) days. |
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Sun, D, Zhang, et al |
Chinese Journal of Digestive Surgery |
Clinical data| Données cliniques |
in Chinese: To invetigate the influencing factors and clinical significance of liver function damage (LFD) in patients
diagnosed with Corona Virus Disease 2019. Of the 51 patients, LFD was detected in 10 patients classified as ordinary type, in 9 patients as severe type, and in 10 as critical type, respectively. In the 51 patients, 1 of 22 patients with normal liver function
developed respiratory failure and received mechanical ventilation within 24 hours after admission, while 9 of 29 patients with abnormal liver function developed respiratory failure and received mechanical ventilation, showing a significant difference between
the two groups (χ2=5.57, P<0.05). (3) Analysis of influencing factors for LFD. Results of univariate analysis showed that clinical classification of COVID-19 as critical type was a related factor for LFD of patients (odds ratio=10.000, 95% confidence interval:
1.050-95.231, P<0.05). |
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32893786; Computed Tomography Evaluation of Airway Changes in Adult Patients with
COVID-19 Pneumonia |
Sun, Z, Liu, et al |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
A total of 275 lesions were detected in 52 patients. Of these, 170 (61.82%) lesions were associated with 243 airway
segments, including segments enclosed within lesions (type I, 152, 62.55%), crossing the lesions (type II, 51, 20.99%), and abutting the lesions (type III, 40, 16.46%). The bronchial walls of 154 (63.37%) segments were ill-defined; whereas, the walls of 89
(36.63%) segments were well-defined; in the latter group, 62 (69.66%) showed mild thickening. The bronchial lumen of 183 (75.31%) segments presented mild bronchiectasis and 60 (24.69%) segments appeared normal. Mucus plug was detected in one segment (0.41%).
There were no cases of bronchial stenosis, and all bronchial segments located in normal lung regions appeared normal. The appearance of 196 (80.66%) affected bronchi was completely restored before hospital discharge. |
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Flattening the covid-19 curve: A myth or reality-a questionnaire based study |
Sunil, MP, Abilasha, et al |
International Journal of Research in Pharmaceutical Sciences |
Public Health response| Interventions de santé publique |
The study aims to assess the knowledge and create awareness of flattening the COVID-19 curves. A survey-based questionnaire
was done to create understanding about ’flattening the curve’. The overall awareness of all subgroups was fair in reporting correct answers. People of the 15-25 age groups mostly attended the survey. (50.7%). 71% of the respondents were males. In this study,
almost 71% of the respondents were aware of the covid-19 curve. Nearly 54% of the respondents believed that community transmission is increasing in their area.71% of the respondents found lockdown can affect India’s economic capital.71% believed lockdown implemented
in India is effective.55.5% of the respondents thought that India is flattening the curve. |
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Assessing Fear and Anxiety of Corona Virus among Dental Practitioners |
Suryakumari, VBP, Pallavi Reddy, et al |
Disaster Med Public Health Prep |
Healthcare Response | Réponse des soins de santé |
METHODOLOGY: An online cross-sectional questionnaire survey comprising of nine questions was conducted among dental
practitioners of Telangana. Age, gender, qualification, type of practice, years of practice, place of residence were the demographic variables recorded. RESULTS: The mean fear and anxiety score of this study population reported was high 6.57 +2.07, with 58.31%
of the population presenting with a low level of fear and anxiety. Only qualification (p=0.045)and gender (p=0.035) revealed a significant difference in fear to Q7and Q8 respectively. Irrespective of the age, gender, qualification, type of practice and years
of practices the levels of fear reported in the present study was high similar. Respondents between 41- 60 yrs age (6.70+ 2.01) and those with individual practices (6.70+2.06) exhibited high level of fear score. |
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Suryavanshi, N, Kadam, et al |
Brain Behav |
Healthcare Response | Réponse des soins de santé |
We sought to assess the mental health and quality of life (QoL) of Indian healthcare professionals (HCPs), the fourth
highest-burden country for COVID-19. Of 197 HCPs assessed, 157 (80%) were from Maharashtra, 130 (66%) from public hospitals, 47 (24%) nurses, 66 (34%) physicians, 101 (52%) females, and 81 (41%) ≤30 years. Eighty-seven percent provided direct COVID-19 care
with 43% caring for >10 patients/day. A large proportion reported symptoms of depression (92, 47%), anxiety (98, 50%), and low QoL (89, 45%). Odds of combined depression and anxiety were 2.37 times higher among single HCPs compared to married (95% CI: 1.03-4.96).
Work environment stressors were associated with 46% increased risk of combined depression and anxiety (95% CI: 1.15-1.85). Moderate to severe depression and anxiety were independently associated with increased risk of low QoL. |
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Taguchi, YH, Turki, et al |
PLoS One |
Therapeutics| Thérapeutique |
We applied the recently proposed method tensor decomposition (TD)-based unsupervised feature extraction (FE) to gene
expression profiles of multiple lung cancer cell lines infected with severe acute respiratory syndrome coronavirus 2. The method identified drug candidate compounds that significantly altered the expression of the 163 genes selected by TD-based unsupervised
FE. Numerous drugs were successfully screened, including many known antiviral drug compounds such as C646, chelerythrine chloride, canertinib, BX-795, sorafenib, sorafenib, QL-X-138, radicicol, A-443654, CGP-60474, alvocidib, mitoxantrone, QL-XII-47, geldanamycin,
fluticasone, atorvastatin, quercetin, motexafin gadolinium, trovafloxacin, doxycycline, meloxicam, gentamicin, and dibromochloromethane. The screen also identified ivermectin, which was first identified as an anti-parasite drug and recently the drug was included
in clinical trials for SARS-CoV-2. The drugs screened using our strategy may be effective candidates for treating patients with COVID-19. |
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Tan, Q, Duan, et al |
Bioorganic chemistry |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
This study aimed to evaluate the effect of oseltamivir against COVID-19. The structures of NRBD, PLpro, and RdRp were
built successfully. The results from TM-align suggested that the S protein, NRBD, 3C-like protease (3CLpro), PLPrO, and RdRp were structurally similar to the influenza A neuraminidase, with TM-scores of 0.30077, 0.19254, 0.28766, 0.30666, and 0.34047, respectively.
Interestingly, the active center of 3CL pro was found to be similar to the active center from the neuraminidase of influenza A. Through an analysis of molecular docking, we discovered that oseltamivir carboxylic acid was more favorable to bind to the active
site of 3CLpro effectively, but its inhibitory effect was not strong compared with the positive group. Finally, we used in vitro study and retrospective case analysis to verify our speculations. We found that oseltamivir is ineffective against SARS-CoV-2 in
vitro study and the clinical use of oseltamivir did not improve the patients’ symptoms and signs and did not slow the disease progression. |
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Rapid and quantitative detection of SARS-CoV-2 specific IgG for convalescent serum
evaluation |
Tan, X, Krel, et al |
Biosensors and Bioelectronics |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
Here, we present a portable microfluidic ELISA technology for rapid (15 min), quantitative, and sensitive detection
of anti-SARS-CoV-2 S1 IgG in human serum with only 8 μL sample volume. We first identified a humanized monoclonal IgG that has a high binding affinity and a relatively high specificity towards SARS-CoV-2 S1 protein, which can subsequently serve as the calibration
standard of anti-SARS-CoV-2 S1 IgG in serological analyses. We then measured the abundance of anti-SARS-CoV-2 S1 IgG in 16 convalescent COVID-19 patients. Due to the availability of the calibration standard and the large dynamic range of our assay, we were
able to identify “qualified donors” for convalescent serum therapy with only one fixed dilution factor (200 ×). Finally, we demonstrated that our technology can sensitively detect SARS-CoV-2 antigens (S1 and N proteins) with pg/mL level sensitivities in 40
min. |
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Tao, J, Zhang, et al |
One Health |
Epidemiology| Épidémiologie Public health interventions*| Interventions de santé publique |
This study aims to analyse the time serial distribution and influencing factors of asymptomatic cases in Hong Kong
with the updated information in the third wave of COVID-19 outbreak, which is highly indicative to mitigating the one health issue of SARS-CoV-2 global transmission. Amidst the third wave of COVID-19 outbreak in Hong Kong, the asymptomatic cases were more
likely to be imported cases. This result suggests it might be necessary to overhaul the quarantine exemption policy under the high importing risk of asymptomatic cases in Hong Kong. |
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Theuerkauff, O, Hanak, et al |
Psychiatria Danubina |
Clinical data| Données cliniques |
We present 3 cases of sudden tobacco use cessation in 3 long-term heavy smokers receiving mental health care for chronic
psychotic disorders. Fear of severe form of COVID-19 was their principal motivation. Nicotine replacement therapy and quitline counseling were provided and no major withdrawal symptoms were declared. As mass media later wrongly presented tobacco use as a
protective factor regarding COVID-19, all three patients resumed smoking. Rigorous counseling took advantage of psychotic symptoms to correct false information and finally promote tobacco use cessation. The COVID-19 pandemic might paradoxically represent a
great motivational factor to quit smoking, espacially when considering patients suffering from severe mental health disorders. |
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Thomas, DSK, Jang, et al |
Int J Disaster Risk Reduct |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
This paper presents a comprehensive conceptual model of cascading disasters that offers a people-centric lens.
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How the Media Places Responsibility for the COVID-19 Pandemic—An Australian Media
Analysis |
Thomas, T, Wilson, et al |
Frontiers in Public Health |
Public Health response| Interventions de santé publique |
The aim of this paper is to investigate where the media places responsibility for COVID-19 in Australia. The results
show that framing of the pandemic was largely based on societal issues with the theme of economic disruption prevalent throughout the study time period. The Australian printed media were slow to report on the COVID-19 pandemic, in addition they were reluctant
to apportion blame until the end of the study period, after confirmed case rates had begun to slow. |
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Tomasino, S, Sassanelli, et al |
Semin Cardiothorac Vasc Anesth |
Clinical data| Données cliniques |
With electrical impedance tomography (EIT) we evaluated, in real time and bedside, the distribution of ventilation
in the different pulmonary regions before, during, and after pronation in COVID-19 respiratory failure. We present a brief literature review of (EIT) in non-COVID-19 patients and a report of 2 COVID-19 patients: one that did not respond well and another one
that improved during and after pronation. EIT might be a useful tool to decide whether prone positioning should or should not be used in COVID-19 pneumonia. |
|
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Alcohol use and mental health status during
the first months of COVID-19 pandemic in Australia |
Tran, TD, Hammarberg, et al |
Journal of affective disorders |
Public Health response| Interventions de santé publique |
This study was an anonymously-completed online self-report survey. A total of 13,829 people contributed complete data
and were included in the analysis. Overall, about one in five adults reported that they had been drinking more alcohol since the COVID-19 pandemic began than they used to. People were more likely to be drinking alcohol more than they used to if they had more
severe symptoms of depression or anxiety. The associations between depressive and anxiety symptoms and increased alcohol use since the COVID-19 pandemic began were consistent between females and males. |
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Effects of the COVID-19 pandemic on breast cancer screening in Taiwan |
Tsai, HY, Chang, et al |
Breast |
Healthcare Response | Réponse des soins de santé |
The breast cancer screening program has continued in Taiwan during the COVID-19 pandemic. Our nationwide data showed
that the total number of screenings decreased by 22.2%, which was more pronounced for in-hospital examinations (−37.2%), while outreach showed a 12.9% decrease. This decline in screening participation happened at all levels of hospitals, more significantly
at the highest level. Our report revealed that outreach services could maintain relatively stable breast cancer screening under this kind of public health crisis. |
|
Tsai, JY, Phua, et al |
J Med Internet Res |
Public Health response| Interventions de santé publique |
The study aims to investigate the relationships between news consumption, trust, intergroup contact, and prejudicial
attitudes toward Asians and Asian Americans residing in the United States during the COVID-19 pandemic. We compare how traditional news, social media use, and biased news exposure cultivate racial attitudes. The moderation effect of media use and trust on
prejudice against Asians is examined. Participants who identified as conservatives (β=.08, P=.02), had personal infection history (β=.12, P=.001), and interacted with Asian people frequently in their daily lives (β=.41, P<.001) reported more negative attitudes
toward Asians after controlling for sociodemographic variables. Relying more on traditional news media (β=.09, P=.04) and higher levels of trust in social media (β=.15, P=.002) were positively associated with prejudice against Asians. In contrast, consuming
news from digital websites or apps (β=-.08, P=.04), left-leaning outlets (β=-.16, P=.001), and neutral outlets (β=-.14, P=.002) led to less prejudicial attitudes toward Asians. Among those who had high trust in social media, exposure had a strong negative
relationship with prejudice. At mean and high levels of trust in digital websites and apps, frequent use reduced unfavorable attitudes toward Asians. |
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Improved Testing and Design of Intubation Boxes During the COVID-19 Pandemic |
Turer, DM, Good, et al |
Annals of Emergency Medicine |
Healthcare Response | Réponse des soins de santé |
This study tested a commercially available passive protective enclosure representing the most common design and compared
this with a modified enclosure that incorporated a vacuum system for active air filtration during simulated intubations and negative-pressure isolation. Qualitative evaluation revealed smoke escaping from all passive enclosure openings. Aerosol leak testing
demonstrated elevated particle concentrations outside the enclosure during simulated intubations. In contrast, vacuum-filter-equipped enclosures fully contained the visible smoke and test aerosol to standards consistent with class I biosafety cabinet certification. |
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Impact of delayed orthodontic care during COVID-19 pandemic: Emergency, disability,
and pain |
Turkistani, KA |
Journal of the World Federation of Orthodontists |
Healthcare Response | Réponse des soins de santé |
The aim of this study was to evaluate the impact of clinical closure and delayed orthodontic care delivery in terms
of types of emergencies, pain intensity, and disability experienced by orthodontic patients during the COVID-19 pandemic. Delay in receiving orthodontic care could result in an orthodontic emergency, yet pain and disability resulting from these events are
minimal. The decision to resume clinical service should be evaluated considering risks and benefits in case of the pandemic. |
|
Ulhaq, ZS, Kristanti, et al |
Data in Brief |
Public Health response| Interventions de santé publique |
Hence, the information regarding Indonesian's ARP towards COVID-19 post-large-scale social restrictions is required.
The data were collected via an online questionnaire, including demographic information (7 items), attitude and practice (5 items), and religious perspective and practice (5 items), from July 11 – 18, 2020, collecting a total of 1,345 respondents. Most believed
that phyiscal distancing cut the spread of SARS-CoV-2 and were feeling anxious about being infected. They also believe that large-scale social restrictions need to be re-implemented. |
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Uscher-Pines, L, Sousa, et al |
Journal of substance abuse treatment |
Healthcare Response | Réponse des soins de santé |
In April 2020, we conducted semistructured interviews with clinicians waivered to prescribe buprenorphine. Eighteen
clinicians representing 10 states participated. Nearly all interview participants were doing some telemedicine, and more than half were only doing telemedicine visits. Most participants reported changing their typical clinical care patterns to help patients
remain at home and minimize exposure to COVID-19. Changes included waiving urine toxicology screening, sending patients home with a larger supply of opioid use disorder (OUD) medications, and requiring fewer visits. Although several participants were serving
new patients via telemedicine during the early weeks of the pandemic, others were not. Some clinicians identified positive impacts of telemedicine on the quality of their patient interactions, including increased access for patients. Others noted negative
impacts including less structure and accountability, less information to inform clinical decision-making, challenges in establishing a connection, technological challenges, and shorter visits. |
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Valdivia, A, Torres, et al |
Journal of Infection |
Epidemiology| Épidémiologie Immunology | Immunologie |
A total of 1,032 patients attended at the emergency department of University Clinic Hospital (HCU)with clinical suspicion
of COVID-19 were tested as per protocol. The SARS-CoV-2 IgM+/IgG- antibody profile was found in sera from 18 patients (1.7%), which were collected at a median of 7 days (range 5-12 days) after the onset of symptoms (1.7%). Following thorough review of medical
charts and based upon clinical, imaging and laboratory findings, repeat negative RT-PCR testing and lack of IgG seroconversion, we came to the conclusion that patients 1,3,4,5,7,9,10,11 and 15 most likely had no COVID-19, whereas patients 2,6,8,12,13 and 14
experienced either possible or probable COVID-19. |
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Vamshi Ram, V, Abilasha, et al |
International Journal of Research in Pharmaceutical Sciences |
Healthcare Response | Réponse des soins de santé |
The study aims to assess the knowledge and create awareness of COVID testing among dental students. A survey-based
questionnaire was done to gener-ate understanding of COVID testing. A questionnaire containing 15 questions was prepared and circulated online using Google forms Statistical analysis was done using SPSS software. The results were obtained, and the data were
anal-ysed. The Overall awareness of all the sub groups was good with more than 90% of the population being aware of the various parameters for Covid test-ing. The study concludes that even though the awareness was reported to be adequate, various measures
have to be taken towards improving the knowledge and continuous updates have to be provided regarding COVID testing to the dental students. © International Journal of Research in Pharmaceutical Sciences. |
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Van Elslande, J, Decru, et al |
Clinical Microbiology and Infection |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
The aim was to determine the antibody response against SARS-CoV-2 spike protein and nucleoprotein using four automated
immunoassays and three ELISAs for the detection of total Ig antibodies (Roche) or IgG (Abbott, Diasorin, Snibe, Euroimmun, Mikrogen) in COVID-19 patients. Sensitivity for all assays was 100% (95% confidence interval 83.7–100) 3 weeks after onset of symptoms.
Specificity varied between 94.7% (88.7–97.8) and 100% (96.1–100). Calculated at the cut-offs that corresponded to a specificity of 95% and 97.5%, Roche had the highest sensitivity (85.0% (79.8–89.0) and 81.1% (76.6–85.7), p < 0.05 except vs. Abbott). Seroconversion
occurred on average 2 days earlier for Roche total Ig anti-N and the three IgG anti-N assays (Abbott, Mikrogen, Euroimmun) than for the two IgG anti-S assays (Diasorin, Euroimmun) (≥50% seroconversion day 9–10 vs. day 11–12 and p < 0.05 for percent seropositive
patients day 9–10 to 17–18). There was no significant difference in the IgG antibody time to seroconversion between critical and non-critical patients. |
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Van Hees, S, Siewe Fodjo, et al |
Epilepsy and Behavior |
Clinical data| Données cliniques Public Health response| Interventions de santé publique |
The objective of this study was to assess access to healthcare and to estimate the prevalence of depression and anxiety
among persons with epilepsy (PWE) during the ongoing coronavirus disease 2019 (COVID-19) pandemic. Methods: We conducted a multicountry online survey among PWE. Persons with epilepsy were invited to participate through various social media channels. The Hospital
Anxiety and Depression Scale (HADS) and 9-item Patient Health Questionnaire (PHQ-9) scale were used to score anxiety and depression. Results: Two hundred three PWE reported symptoms of a cold since January 2020. Nine (25%) of the 36 PWE tested for COVID were
positive. A total of 72 PWE (19.6%) reported problems to obtain antiseizure medication (ASM), which in 25% of cases was directly COVID-related. Of the 399 PWE, 201 (50.4%) screened positive for anxiety according to the HADS; 159 (39.8%) and 187 (46.9%) PWE
screened positive for depression based on the HADS and PHQ-9 scale, respectively. Female gender and financial problems were associated with both depression and anxiety. |
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Vena, A, Giacobbe, et al |
Clinical Microbiology and Infection |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
To describe clinical characteristics, management and outcome of individuals with coronavirus disease 2019 (COVID-19);
and to evaluate risk factors for all-cause in-hospital mortality. The most common underlying diseases were hypertension (149/317; 47.0%), cardiovascular disease (63/317; 19.9%) and diabetes (49/317; 15.5%). Common symptoms at the time of COVID-19 diagnosis
included fever (285/317; 89.9%), shortness of breath (167/317; 52.7%) and dry cough (156/317; 49.2%). On multivariable analysis, age (per-year increase OR 1.07; 95% CI 1.04–1.10; p < 0.001), cardiovascular disease (OR 2.58; 95% CI 1.07–6.25; p 0.03), and
C-reactive protein levels (per-point increase OR 1.009; 95% CI 1.004–1.014; p 0.001) were independent risk factors for all-cause in-hospital mortality. |
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SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology |
Veras, FP, Pontelli, et al |
J Exp Med |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We investigated whether neutrophil extracellular traps (NETs) would be involved in COVID-19 pathophysiology. A cohort
of 32 hospitalized patients with a confirmed diagnosis of COVID-19 and healthy controls were enrolled. The concentration of NETs was augmented in plasma, tracheal aspirate, and lung autopsies tissues from COVID-19 patients, and their neutrophils released higher
levels of NETs. Notably, we found that viable SARS-CoV-2 can directly induce the release of NETs by healthy neutrophils. Mechanistically, NETs triggered by SARS-CoV-2 depend on angiotensin-converting enzyme 2, serine protease, virus replication, and PAD-4.
Finally, NETs released by SARS-CoV-2–activated neutrophils promote lung epithelial cell death in vitro. These results unravel a possible detrimental role of NETs in the pathophysiology of COVID-19. Therefore, the inhibition of NETs represents a potential therapeutic
target for COVID-19. |
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Verstockt, B, Verstockt, et al |
J Crohns Colitis |
Clinical data| Données cliniques |
We investigated the role of intestinal inflammation on the viral intestinal entry mechanisms, including ACE2, in IBD.
Intestinal inflammation alters SARS-CoV-2 coreceptors in the intestine, with opposing dysregulations in ileum and colon. HNF4A, an IBD susceptibility gene, seems an important upstream regulator of ACE2 in ileum, whereas interferon signaling might dominate
in colon. |
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Vilella Mitjana, Felipe, Wang, et al |
bioRxiv |
Coronavirology| Coronavirologie |
We investigated potential SARS-CoV-2 tropism in human endometrium by single-cell RNA-sequencing of viral entry-associated
genes in healthy women. Percentages of endometrial cells expressing ACE2, TMPRSS2, CTSB, or CTSL were <2%, 12%, 80%, and 80%, respectively, with 0.7% of cells expressing all four genes. Our findings imply low efficiency of SARS-CoV-2 infection in the endometrium
before embryo implantation, providing information to assess preconception risk in asymptomatic carriers. |
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Villani, ER, Carfì, et al |
Am J Med Genet A |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study assessed the epidemiological and clinical characteristics of individuals with Down syndrome (DS) deceased
in Italian hospitals with CoVID-19. Sixteen cases of death in individuals with DS (0.5% of all charts analyzed) were identified. Acute respiratory distress syndrome occurred in all 16 cases. Compared with individuals without DS, those with DS deceased with
CoVID-19 were younger (52.3 ± 7.3 vs. 78.1 ± 10.6 years, p < .001) and presented a higher incidence of superinfections (31.2 vs. 13.0%, p = .029). Autoimmune diseases (43.8 vs. 4%, p < .001), obesity (37.5 vs. 11%, p = .009), and dementia (37.5 vs. 16.3%,
p = .012) were more prevalent in individuals with DS. ICU admissions was similar in both groups (25 vs. 18.8%, p = .129). |
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Vorobeva, OV, Lastochkin, et al |
Russian Journal of Infection and Immunity |
Clinical data| Données cliniques |
This study describes a case of severe COVID-19 with development of multiple organ failure. Female patient, 69 years
old, was admitted to the therapeutic department and diagnosed with coronary heart disease and COVID-19. The patient’s condition was aggravated while applying therapy and death occurred. This clinical and morphological case demonstrates, in addition to lung
damage, involvement in the process of the heart with the development of acute coronary syndrome (morphologically manifested by ischemic myocardial dystrophy) and the brain. |
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Waghmare, A, Shrivastava, et al |
International Journal of Research in Pharmaceutical Sciences |
Healthcare Response | Réponse des soins de santé |
In this study, all the trauma patients coming to Acharya Vinobha Bhave Rural Hospital, Wardha were included irre-pective
of their age and mode of trauma. Period of two weeks before and two weeks after the initiation of lockdown in India from 23rd march 2020 have been taken into consideration. Both the outpatient and emergency patients were included in our study. We have observed
a significant fall on overall trauma cases as expected due to the lockdown. There was a fall in the total number of cases by around three times. Our study showed that the demography of geriatric trauma, which remained almost the same and nearly all of them
were old age females. Low-velocity trauma has shown an increase after lockdown from 42% to 64%, while the total numbers of cases are still less as compared to before the lockdown. High-velocity trauma cases have been reduced from 52% to 31% after lockdown,
which indicates less road traffic-related injuries. During the lockdown, however, we have seen a significant fall in head neck and face trauma when compared to the upper limb and lower limb trauma. |
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The impacts of a COVID-19 epidemic focus and general belief in a just world on
individual emotions |
Wang, J, Wang, et al |
Personality and Individual Differences |
Public Health Priorities| Priorités de santé publique Public Health response| Interventions
de santé publique |
This study conducted two experiments to explore this question during the COVID-19 epidemic. Experiment 1 (N = 92, Mage
= 22.52, 48.91% was male) manipulated the focus regarding the COVID-19 epidemic to investigate the impact of this focus on participants' emotions. The results showed that compared with the nonepidemic focus group, the epidemic focus group had higher negative
emotions and lower positive emotions. Experiment 2 (N = 200, Mage = 23.91, 49% was male) manipulated the epidemic focus and GBJW to investigate their effects on the participants' emotions. The results showed that high levels of "general belief in a just world"
GBJW reduced negative emotions and increased positive emotions regardless of whether the participants were focused on the epidemic. This study expands the influence of the GBJW on individual emotions and finds that the GBJW can protect individuals' emotions
when they face a major social disaster. These findings imply that controlling people's intake of information on the epidemic can avoid their suffering from the vicarious traumatization caused by epidemic-related information overload and that improving the
public's GBJW protects their mental health during an epidemic. |
|
Wang, N, Han, et al |
Phytomedicine |
Therapeutics| Thérapeutique |
Chloroquine (CQ) and Hydroxychloroquine (HCQ) have been reported to treat the disease, but the underlying mechanism
remains controversial. Purpose: The objective of this study is to investigate whether CQ and HCQ could be ACE2 blockers and used to inhibit 2019-nCoV virus infection. Methods: In our study, we used CCK-8 staining, flow cytometry and immunofluorescent staining
to evaluate the toxicity and autophagy of CQ and HCQ, respectively, on ACE2 high-expressing HEK293T cells (ACE2h cells). We further analyzed the binding character of CQ and HCQ to ACE2 by molecular docking and surface plasmon resonance (SPR) assays, 2019-nCoV
spike pseudotyped virus was also used to observe the viropexis effect of CQ and HCQ in ACE2h cells. Results: Results showed that HCQ is slightly more toxic to ACE2h cells than CQ. Both CQ and HCQ could bind to ACE2 with KD = (7.31 ± 0.62)e−7 M and (4.82 ±
0.87)e−7 M, respectively. They exhibit equivalent suppression effect for the entrance of 2019-nCoV spike pseudotyped virus into ACE2h cells. Conclusions: CQ and HCQ both inhibit the entrance 2019-nCoV into cells by blocking the binding of the virus with ACE2.
Our findings provide novel insights into the molecular mechanism of CQ and HCQ treatment effect on virus infection. |
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Deep Learning for the Detection of COVID-19 Using Transfer Learning and Model
Integration |
Wang, N, Liu, et al |
|
Clinical data| Données cliniques Diagnostics / Pathogen detection| Diagnostics / Détection
d'agents pathogènes |
We researched the diagnostic capabilities of deep learning on chest radiographs and an image classifier based on the
COVID-Net was presented to classify chest X-Ray images. In the case of a small amount of COVID-19 data, data enhancement was proposed to expanded COVID-19 data 17 times. Our model aims at transfer learning, model integration and classify chest X-Ray images
according to three labels: normal, COVID-19 and viral pneumonia. According to the accuracy and loss value, choose the models ResNet-101 and ResNet-152 with good effect for fusion, and dynamically improve their weight ratio during the training process. After
training, the model can achieve 96.1% of the types of chest X-Ray images accuracy on the test set. This technology has higher sensitivity than radiologists in the screening and diagnosis of lung nodules. As an auxiliary diagnostic technology, it can help radiologists
improve work efficiency and diagnostic accuracy. © 2020 IEEE. |
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Wang, Q, Luo, et al |
Patient Preference and Adherence |
Healthcare Response | Réponse des soins de santé |
Purpose: The COVID-19 epidemic has caused difficulties in continuous treatment for patients with chronic diseases and
resulted in nonadherence to treatment and adverse health outcomes. This study aimed to investigate the associations of nonadherence to treatment with patient-reported outcomes of psoriasis during the COVID-2019 epidemic. Methods: A cross-sectional study among
Chinese patients with psoriasis was conducted through a web-based questionnaire survey during 25 Feb 2020 and 6 Mar 2020. Demographic and clinical data, nonadherence to treatment, and patient-reported outcomes were collected. The outcomes included deterioration
of the disease condition, perceived stress, and symptoms of anxiety and depression. Logistic regression was used to investigate the associations. Results: A total of 926 questionnaires were collected. A total of 634 (68.5%) reported nonadherence to treatment,
and worse adherence was found among patients receiving systemic treatment (adjusted odds ratio AOR]: 2.67; 95% CI: 1.40–5.10) and topical treatment (AOR: 4.51; 95% CI: 2.66–7.65) compared to biological treatment. Nonadherence to treatment (less than two weeks
and more than two weeks) was significantly associated with deterioration of psoriasis (a OR: 2.83 to 5.25), perceived stress ( |
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Wang, Q, Qiu, et al |
Transboundary and Emerging Diseases |
Coronavirology| Coronavirologie |
SARS-CoV and SARS-CoV-2 most likely originated from bats. Thus, direct or indirect inter-species transmission from
bats to humans is required for the viruses to cause pandemics. Receptor utilization is a key factor determining the host range of viruses which is critical to the inter-species transmission. Angiotensin-converting enzyme 2 (ACE2) is the receptor of both SARS-CoV
and SARS-CoV-2, but only ACE2s of certain animals can be utilized by the viruses. We employed pseudovirus cell-entry assay to evaluate the receptor-utilizing capability of ACE2s of 20 animals by the two viruses and found that SARS-CoV-2 utilized less ACE2s
than SARS-CoV, indicating a narrower host range of SARS-CoV-2. The actual susceptibility of these animals to the coronaviruses should be further verified by in vivo studies. Our studies enhance the understanding of receptor utilization of pandemic coronaviruses,
potentially contributing to the virus tracing, intermediate host screening and epidemic prevention for pathogenic coronaviruses. |
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The Prognostic Nutritional Index is associated with mortality
of COVID-19 patients in Wuhan, China |
Wang, R, He, et al |
J Clin Lab Anal |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We designed this study to develop a prognostic nomogram incorporating Prognostic nutritional index (PNI) in COVID‐19
patients. Comparison of baseline characteristics showed non‐survivors had higher age (P < .001), male ratio (P = .038), neutrophil‐to‐lymphocyte ratio (NLR) (P < .001), platelet‐to‐lymphocyte ratio (PLR) (P < .001), and PNI (P < .001) than survivors. In the
multivariate logistic regression analysis, independent risk factors of mortality in COVID‐19 patients included white blood cell (WBC) (OR 1.285, P = .039), PNI (OR 0.790, P = .029), LDH (OR 1.011, P < .015). These three factors were combined to build the prognostic
model. Area under the ROC curve (AUC) of only PNI and the prognostic model was 0.849 (95%Cl 0.811‐0.888) and 0.950 (95%Cl 0.922‐0.978), respectively. And calibration plot showed good stability of the prognostic model. |
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Wang, Y, Zhu, et al |
Sleep medicine |
Public Health response| Interventions de santé publique |
The purpose of this study was to examine insomnia disorder and its association with sociodemographic factors and poor
mental health in 2019 novel coronavirus (COVID-19) inpatients in Wuhan, China. The prevalence of insomnia disorder in the whole sample was 42.8%. Binary logistic regression analysis revealed that female gender, younger age, and higher fatigue and anxiety severity
were more likely to experience insomnia disorder. |
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Identification of Key Genes and Pathways in SARS-CoV-2 Infection using
Bioinformatics Analysis |
Wang, Zhe, Jiang, et al |
Research Square prepub |
Clinical data| Données cliniques Immunology | Immunologie |
Study aimed to utilize bioinformatics method to analyze the expression profiling by high throughput sequencing in human
bronchial organoids/primary human airway epithelial infected with SARS-CoV-2 to identify the potentially crucial genes and pathways associated with COVID-19. Methods: We analyzed microarray datasets GSE153970 and GSE150819 derived from the GEO database. Firstly,
the Differentially expressed genes （DEGs）
in human bronchial organoids/primary human airway epithelial infected with SARS-CoV-2. Next, the DEGs were used for GO and KEGG pathway enrichment analysis. Then, the PPI network was constructed and Cytoscape was used to find the key genes. Results: Gene expression
profiles of GSE153970 and GSE150819, in all 12 samples were analyzed. A total of 145 DEGs and 5 hub genes were identified in SARS-CoV-2. Meanwhile, we found that the 145 genes are associated with immune responses and the top 5 hub genes including CXCL8, CXCL1,
CXCL2, CCL20, and CSF2 were mainly related to leukocyte migration, endoplasmic reticulum lumen, receptor ligand activity. In addition, the results also showed that the hub genes were associated with Cytokine−cytokine receptor interaction, IL−17 signaling pathway,
and Rheumatoid arthritis in SARS-CoV-2 infection. Conclusion: The five crucial genes consisting of CXCL8, CXCL1, CXCL2, CCL20, and CSF2 were considered as hub genes of SARS-CoV-2, which may be used as diagnostic biomarkers or molecular targets for the treatment
of SARS-CoV-2. It is evidenced that bioinformatics analyses in SARS-CoV-2 can be useful for understanding the underlying molecular mechanism and exploring effective therapeutic targets. |
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Wei, C, Bai, et al |
Biointerface Research in Applied Chemistry |
Clinical data| Données cliniques |
We report 3 cases of using hydroxychloroquine in the treatment of critically ill COVID-19 patients. Results show that
hydroxychloroquine treatment may benefit nucleic acid testing, turning negative in these patients. |
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Tracking disease outbreaks from sparse data with Bayesian inference |
Wilder, Bryan, MinaMichaelJ, et al |
arXiv |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie |
We propose a Bayesian framework which accommodates partial observability in a principled manner. Our model places a
Gaussian process prior over the unknown reproduction number at each time step and models observations sampled from the distribution of a specific testing program. For example, our framework can accommodate a variety of kinds of tests (viral RNA, antibody,
antigen, etc.) and sampling schemes (e.g., longitudinal or cross-sectional screening). Inference in this framework is complicated by the presence of tens or hundreds of thousands of discrete latent variables. To address this challenge, we propose an efficient
stochastic variational inference method which relies on a novel gradient estimator for the variational objective. Experimental results for an example motivated by COVID-19 show that our method produces an accurate and well-calibrated posterior, while standard
methods for estimating the reproduction number can fail badly. |
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Impact of glycan cloud on the B-cell epitope prediction of SARS-CoV-2 Spike protein |
Wintjens, R, Bifani, et al |
npj Vaccines |
Coronavirology| Coronavirologie |
We model the trimeric Spike protein, including flexible loops and all N-glycosylation sites, in order to elucidate
accessible epitopes for antibody-based diagnostics, therapeutics and vaccine development. We identify 28 B-cell epitopes in the Spike structure and group them as non-affected by the glycan cloud versus those which are strongly masked by the glycan cloud, resulting
in a list of favourable epitopes as targets for vaccine development, antibody-based therapy and diagnostics. |
|
Healthcare
workers in Singapore infected with COVID-19: 23 January-17 April 2020 |
Wong, LY, Tan, et al |
Influenza Other Respir Viruses |
Epidemiology| Épidémiologie |
The objective of this study was to describe the characteristics of healthcare workers (HCWs) infected with COVID-19
and to examine their sources of exposure. |
|
Wu, Yu Han, Meng, et al |
Research Square prepub |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
By analyzing characteristics and causes of anemia in 46 severe and critically severe COVID-19 patients that we treated,
we aim to provide information on pathogenesis and the treatment method of COVID-19.Among the 50 COVID-19 patients, 46 patients suffered from normocytic autoimmune hemolytic anemia. The occurrence and severity of anemia was related to changes in titer of novel
coronavirus IgM and IgG antibodies (r=0.071, P=0.897; r =0.41, P=0.361). The changes of the average Hb concentration and changes of average drug concentration of patients with anemia showed that anemia had a significant negative correlation with Arbidol (r=-
0.758, P=0.029), but no significant correlation with Ribavirin, Interferon α-2b and magnesium isoglycyrrhizinate(P＞0.05). |
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PMC7438071; Management and Outcomes of Patients With STEMI During the COVID-19
Pandemic in China |
Xiang, D, Xiang, et al |
J Am Coll Cardiol |
Healthcare Response | Réponse des soins de santé |
This study evaluates the impact of the COVID-19 outbreak and China Chest Pain Center’s modified STEMI protocol on the
treatment and prognosis of STEMI patients in China. The COVID-19 outbreak reduced the number of STEMI cases reported to China Chest Pain Centers. Consistent with China Chest Pain Center’s modified STEMI protocol, the percentage of patients undergoing primary
percutaneous coronary intervention declined while the percentage of patients undergoing thrombolysis increased. With an average delay of approximately 20 min for reperfusion therapy, the rate of in-hospital mortality and in-hospital heart failure increased
during the outbreak, but the rate of in-hospital hemorrhage remained stable. |
|
Xiao, Y, Shi, et al |
Virulence |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to perform cause analysis of RT-PCR turn-positive and the effective screening factors related to treatment
outcome in COVID-19. 116 COVID-19 patients (40 in recurrent group, 29 in recovered group and 47 in unrecovered group) were recruited. In the recurrent group, white blood cell, Neutrophils, prothrombin time, activated partial thromboplastin time, CD3, CD4,
CD8, ratio of CD4/CD8, IgG and C4 complement were of significant difference among the baseline, negative and turn-positive time points. CD19 and CT scan results were found notable difference between recurrent group and recovered group. Odds from CD3, CD4,
CD8, CD19, IgM, C3 complement, C4 complement and CT scan results validated associations with clinical outcomes of COVID-19. The so-called recurrence in some COVID-19 patients may be due to the false-negative of nucleic acid test results from nasopharyngeal
swabs. Levels of CD3, CD4, CD8, CD19, IgM, C3 complement, C4 complement and CT results were significantly correlated with the outcome of COVID-19. The cellular immunity test could be beneficial to further screen the reliability of RT-PCR test on the basis
of CT images. |
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Xie, J, Luo, et al |
Sustainability (Switzerland) |
Public Health response| Interventions de santé publique |
This paper emphasizes the critical role of urban parks during the pandemic period from the perspective of the urban
building environment. This survey was conducted from 1–5 April 2020; it collected 386 responses from residents of Chengdu, China, during the pandemic based on an online survey questionnaire. The results indicate that most of the residents believe their health
status is poor, and that they do not experience adequate social contact with others. Most of the respondents indicated no difference in mental health, while a few reported differences in their physical health and social interaction levels. The conclusion affirms
that urban parks and large outdoor, open spaces can provide residents with a place for safe outdoor activities and social interaction in a green environment during a pandemic, as well as serve as a buffer area to maintain favorable health and quality of life. |
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Xie, J, Sun, et al |
Kexue Tongbao/Chinese Science Bulletin |
Modelling/ prediction| Modélisation/prédiction Epidemiology| Épidémiologie Public health
interventions*| Interventions de santé publique |
we performed a stage-rolling Susceptible-Exposed-Infectious-Recovered (SEIR) model to measure the evolution of the
basic reproduction number of COVID-19, based on the number of confirmed infections announced by the National Health Commission of the People’s Republic of China. |
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Xie, T, Tan, et al |
Risk Management and Healthcare Policy |
Public Health response| Interventions de santé publique |
The aim of this study was to investigate the reaction of global Internet users to the outbreak of COVID-19. After the
outbreak of COVID-19, both daily Baidu Attention Index and daily Google Trends increased rapidly and remained at a high levels. When major events occurred, daily BAI, daily GT, and the number of rumors simultaneously reached new peaks. Our study indicates
that these indexes and rumors are statistically related to disease-related indicators. Information symmetry was also found to help significantly eliminate the false news and to prevent rumors from spreading across social media through the epidemic outbreak. |
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Xie, TA, Han, et al |
J Cell Mol Med |
Coronavirology| Coronavirologie |
This study focused on gene expression in three types of cells infected with SARS‐CoV‐2, including primary human lung
epithelium (NHBE), transformed lung alveolar (A549) cells and transformed lung‐derived Calu‐3 cells. The original microarray data of GSE147507 were obtained from Gene Expression Omnibus (GEO). The study was designed to identify key biomarker candidates for
SARS‐CoV‐2 and improve the diagnosis and prognosis based on functional and molecular analyses by evaluating DEGs in three groups. |
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Xu, L, Liang, et al |
Kexue Tongbao/Chinese Science Bulletin |
Diagnostics / Pathogen detection| Diagnostics / Détection d'agents pathogènes |
To establish the measurement traceability for SARS-CoV-2 RNA detection, a novel RNA reference material (RM) was developed.
The RM is a mixed solution of 3 in vitro transcribed RNA molecules which cover different key target sequences of SARS-CoV-2 gene. Our RNA RMs showed high generalizability among 9 kits. The development of RNA RM provides the metrological basis for the quality
control of SARS-CoV-2 detection kits. |
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COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2 |
Xu, L, Yu, et al |
Zool Res |
Clinical data| Données cliniques Animal model | Modèle animal |
Identifying animal species susceptible to infection with the SARS-CoV-2/ HCoV-19 pathogen is essential for controlling
the outbreak and for testing valid prophylactics or therapeutics based on animal model studies. Here, different aged Chinese tree shrews (adult group, 1 year old; old group, 5-6 years old), which are close relatives to primates, were infected with SARS-CoV-2.
X-ray, viral shedding, laboratory, and histological analyses were performed on different days post-inoculation (dpi). Results showed that Chinese tree shrews could be infected by SARS-CoV-2. Lung infiltrates were visible in X-ray radiographs in most infected
animals. Viral RNA was consistently detected in lung tissues from infected animals at 3, 5, and 7 dpi, along with alterations in related parameters from routine blood tests and serum biochemistry, including increased levels of aspartate aminotransferase (AST)
and blood urea nitrogen (BUN). Histological analysis of lung tissues from animals at 3 dpi (adult group) and 7 dpi (old group) showed thickened alveolar septa and interstitial hemorrhage. Several differences were found between the two different aged groups
in regard to viral shedding peak. Our results indicate that Chinese tree shrews have the potential to be used as animal models for SARS-CoV-2 infection. |
|
Yamagishi, T, Ohnishi, et al |
The Journal of infectious diseases |
Epidemiology| Épidémiologie Transmission |
During a COVID-19 outbreak on the Diamond Princess cruise ship we sampled environmental surfaces after passengers and
crew vacated cabins. SARS-CoV-2 RNA was detected in 58 of 601 samples (10%) from case cabins 1-17 days after cabins were vacated but not from noncase cabins. There was no difference in detection proportion between cabins of symptomatic (15%, 28/189; cycle
quantification Cq], 29.79-38.86) and asymptomatic cases (21%, 28/131; Cq, 26.21-38.99). No SARS-CoV-2 virus was isolated from any of the samples. Transmission risk of SARS-CoV-2 from symptomatic and asymptomatic patients may be similar and surfaces could be
involved in transmission. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. |
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Low serum calcium and phosphorus and their clinical performance in detecting
COVID-19 patients |
Yang, C, Ma, et al |
J Med Virol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to evaluate the predictive performance of low serum calcium and phosphorus in discriminative diagnosis
of the severity of COVID‐19 patients. Low calcium and low phosphorus are more prevalent in severe/critical COVID‐19 patients than moderate COVID‐19 patients (OR 15.07, 95%CI 1.59 ‐143.18 for calcium, OR 6.90, 95%CI 2.43 ‐ 19.64 for phosphorus). The specificity
in detecting the severe/critical patients among COVID‐19 patients reached 98.5% (95%CI 92.0‐99.7%) and 84.4% (95%CI 74.3‐91.6%) by low calcium and low phosphorus, respectively, albeit with suboptimal sensitivity. Calcium and phosphorus combined with lymphocyte
count could obtain the best discriminative performance for the severe COVID‐19 patients (area under the curve (AUC) = 0.80), and combined with oxygenation index was promising (AUC = 0.71). Similar discriminative performances of low calcium and low phosphorus
were found between suspected and confirmed COVID‐19 patients. |
|
Yang, C, Zhou, et al |
J Clin Nurs |
Healthcare Response | Réponse des soins de santé |
This study investigates the effect of a short‐term Balint group on the improvement in communication ability and self‐efficacy
of pre‐examination and triage nurses during coronavirus disease 2019 (COVID‐19). Most of the subjects reported improvement in nurse‐patient communication, increased cooperation between patients and their families, and a decreased missed examination rate after
the intervention. Moreover, the total mean score of the GSES of nurses after the intervention was increased, but the difference was not statistically significant. The scores of all items in the GSES were improved, and the scores increase for item 4 (I am confident
that I can effectively deal with any unexpected event) was statistically significant. |
|
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Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor |
Yang, J, Petitjean, et al |
Nat Commun |
Coronavirology| Coronavirologie Therapeutics| Thérapeutique |
We use atomic force microscopy to investigate the mechanisms by which the S-glycoprotein binds to the ACE2 receptor.
We demonstrate, both on model surfaces and on living cells, that the receptor binding domain (RBD) serves as the binding interface within the S-glycoprotein with the ACE2 receptor and extract the kinetic and thermodynamic properties of this binding pocket.
we test several binding inhibitor peptides targeting the virus early attachment stages, offering new perspectives in the treatment of the SARS-CoV-2 infection. |
|
Yang, M, Chen, et al |
Med Sci Monit |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
The aim of this study was to determine the effect of C-reactive protein (CRP), lymphocytes (LYM), and the ratio of
CRP to LYM (CRP/LYM) on assessing the prognosis of COVID-19 severity at early stages of disease. The effect of CRP/LYM and CRP on the assessment for severe COVID-19 may be superior to LYM alone. CRP/LYM is a highly sensitive indicator to assess the severity
of COVID-19 in the early stage of disease. |
|
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Origin-independent analysis links SARS-CoV-2 local genomes with COVID-19 incidence and
mortality |
Yang, W, Jin, et al |
Brief Bioinform |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie |
To ensure unbiased and origin-independent analyses, we used a pairwise comparison of local genome sequences of virus
genomes by Basic Local Alignment Search Tool (BLAST). We found a strong statistical correlation between dominance of the SARS-CoV-2 in distributions of uneven similarities and the incidence and mortality of illness. Genomic annotation of the BLAST hits also
showed that viruses from geographic regions with severe infections tended to have more dynamic genomic regions in the SARS-CoV-2 receptor-binding domain (RBD) and receptor-binding motif (RBM) of the spike protein (S protein). Dynamic domains in the S protein
were also confirmed by a canyon region of mismatches coincident with RBM and RBD, without hits of alignments of 100% matching. Thus, our origin-independent analysis suggests that the dynamic and unstable SARS-CoV-2-RBD could be the main reason for diverse
incidence and mortality of COVID-19 infection. |
|
Determinants of physical activity maintenance
during the Covid-19 pandemic: a focus on fitness apps |
Yang, Y, Koenigstorfer, et al |
Transl Behav Med |
Public Health response| Interventions de santé publique |
This study aims to investigate changes in U.S. residents' physical activity (PA) during (vs. before) the Covid-19 pandemic
and predictors of changes, with a focus on PA smartphone applications (apps) and their features (i.e., motivational, educational, or gamification related). The study utilized a two-wave longitudinal survey design with an online panel. Healthy adults (N = 431)
from 45 U.S. states self-reported their PA levels before and during lockdown. PA app use and app feature ratings were assessed. t-tests and regression analyses were conducted. Moderate PA, vigorous PA, and PA measured in metabolic equivalent of task (MET)
minutes per week decreased during lockdown (all p < .01). Controlling for PA before lockdown and individuals' PA intentions, PA app use was positively related to overall change in PA, measured in MET minutes per week (β = 15.68, standard error = 7.84, p <
.05). PA decreased less with increasing app use frequency. When app features were added to the model, a buffering effect for gamification features was identified. The Covid-19-caused lockdown decreased U.S. residents' PA levels by 18.2%. The use of PA apps
may help buffer the decline, and gamification-related app features may be particularly helpful in this context. |
|
Yao, Qingsong, Xiao, et al |
arXiv |
Clinical data| Données cliniques |
We herein present a label-free approach for segmenting COVID-19 lesions in CT via pixel-level anomaly modeling that
mines out the relevant knowledge from normal CT lung scans. Our modeling is inspired by the observation that the parts of tracheae and vessels, which lay in the high-intensity range where lesions belong to, exhibit strong patterns. To facilitate the learning
of such patterns at a pixel level, we synthesize `lesions' using a set of surprisingly simple operations and insert the synthesized `lesions' into normal CT lung scans to form training pairs, from which we learn a normalcy-converting network (NormNet) that
turns an 'abnormal' image back to normal. Our experiments on three different datasets validate the effectiveness of NormNet, which conspicuously outperforms a variety of unsupervised anomaly detection (UAD) methods. |
|
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Yao, SY, Lei, et al |
Chin J Integr Med |
Clinical data| Données cliniques |
A 37-year old male patient was admitted to the Xiangtan Central Hospital on Jan 28, 2020 |
|
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The first case of COVID-19 infant in Sichuan Province: case report and literature
review |
Ye, Y, Sun, et al |
Chinese Journal of Obstetrics and Gynecology and Pediatrics |
Clinical data| Données cliniques |
in chinese: case report infant. The results of the Mycoplasma pneumonia, Chlamydophila pneumonia, influenza A and B
virus antigens all were negative after admission. Chest CT examination results showed that multiple subpleural light ground glass opacities were found in both lungs. Two times of nasopharyngeal swabs of SARS-CoV-2 both were positive with RT-PCR test, and the
infant was confirmed as COVID-19 based on epidemiological data, clinical manifestations, imaging findings, and RT-PCR test results. Clinical symptoms of shortness of breath and cough disappeared, lung lesions absorbed on chest imaging, and RT-PCR test turned
to negative after symptomatic treatment of the infant. Currently, the infant was observed continually and waited for discharge |
|
Efficacy of umifenovir in the treatment of mild and moderate covid-19 patients |
Yethindra, V, Tagaev, et al |
International Journal of Research in Pharmaceutical Sciences |
Clinical data| Données cliniques Therapeutics| Thérapeutique RCT |
This exploratory randomized and controlled study recruited 30 COVID-19 patients admitted to the hospital until May
18, 2020. Fifteen eligible patients randomly allocated underwent umifenovir therapy (600 mg/d). Thirty COVID-19 patients (mean age: 36.5 years SD: 12.1, range: 19-59]), including 18 (60%) males and 12 (40%) females, were recruited for the study. There were
no significant differences in age or gender, but there were significant differences in TTCR among the two categories. Body temperature (BT) and cough recuperation time 2.8 (0.6) and 2.6 (0.6) days, respectively were highly reduced in the umifenovir category
at 2.4 and 2.1 days, respectively. Moreover, many patients treated with umifenovir exhibited no side effects. In this study, pneumonia was ameliorated in 76.6% (23/30) of the patients, with moderate and potential amelioration in 36.6% and 40% of the patients,
respectively. In addition, 66.6% of the patients in the umifenovir category had potential pneumonia absorption. |
|
Quantitative microbial risk assessment of SARS-CoV-2 for workers in wastewater
treatment plants |
Zaneti, RN, Girardi, et al |
Science of the Total Environment |
Epidemiology| Épidémiologie Transmission |
This is the first study that investigates the potential health risks of SARS-CoV-2 in sewage to wastewater treatment
plant (WWTP) workers. A quantitative microbial risk assessment (QMRA) is applied for three COVID-19 scenarios (moderate, aggressive and extreme) to study the effects of different stages of the pandemic in terms of percentage of infected population on the probability
of infection to WWTP workers. Results reveal that estimates of viral RNA in sewage at the entrance of WWTPs ranged from 4.14 × 101 to 5.23 × 103 GC·mL−1. In addition, estimated risks for the aggressive and extreme scenarios were likely to be above the derived
tolerable infection risk for SARS-CoV-2 of 5.5 × 10−4 pppy, thus reinforcing the concern of sewage systems as a possible transmission pathway of SARS-CoV-2. |
|
Zeidan, S, Maillart, et al |
J Neurol |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
We conducted a monocentric retrospective case-series study of Neuromyelitis optica spectrum disorders (NMO/SD) patients
with highly suspected or proven COVID-19. They fulfilled at least one of the three NMO diagnostic criteria sets and were registered in the NOMADMUS cohort (gathering data from French expert NMO/SD centers). |
|
|
Zhang, GX, Sanabria, et al |
Neurologia |
Public Health response| Interventions de santé publique |
We wanted to compare the socio-labor effect of confinement in two populations as different as Spain and China, in patients
with MS. The Chinese population has a higher proportion of younger patients and there is no difference regarding gender. Most of the variables studied behaved the same way in both Spanish and Chinese MS patients. Spanish patients had less impact (30.7%) on
their socio-economic situation than Chinese (44%), P < .05. |
|
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32884226; Clinical characteristics and risk factors for liver injury in COVID-19
patients in Wuhan |
Zhang, H, Liao, et al |
World journal of gastroenterology |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
This study aimed to investigate the clinical characteristics and risk factors for liver injury in COVID-19 patients
in Wuhan. The 218 patients included 94 males (43.1%), aged 22 to 94 (50.1 ± 18.4) years. Multivariate analysis revealed that male sex, high D-dimer level, and high neutrophil percentage were linked to a higher risk of liver injury. The early stage of COVID-19
may be associated with mildly elevated aminotransferase levels in patients in Wuhan. Male sex and high D-dimer level and neutrophil percentage may be important predictors of liver injury in patients with COVID-19. |
|
Zhang, S, Wang, et al |
Frontiers in Public Health |
Infection Prevention and Control/ Prévention et contrôle des infections (IPAC/PCI)
Healthcare Response | Réponse des soins de santé |
Authors analyzed 31 high-frequency contact sites in three isolation wards of actively sick patients, of which seven
were positive. Positive sites included the transfer window, bed rail, buffer room door handle, toilet door handle, and toilet faucet. All 55 samples taken from the wards of cured patients and the wards after terminal disinfection were negative. Virus contamination
in areas frequently touched by patients in the isolation ward was high, so the awareness of correct disinfection must be increased. Use of 1,000–2,000 mg/L chlorine-containing disinfectant in the isolation ward was effective. |
|
|
Zhang, Y, Wang, et al |
Chinese Journal of Obstetrics and Gynecology and Pediatrics |
Healthcare Response | Réponse des soins de santé |
In Chinese: From 21 January, 2020 to 19 February, 2020, a total of 35 children with Kawasaki disease and complicated
with CAL who received long-term treatment in the Department of Cardiovascular of Chengdu Women's and Children's Central Hospital and needed to go to the hospital for referral during epidemic outbreak period were selected as research subjects. During COVID-19
epidemic period, intervention of MDT based on PCM-online achieves the purpose of epidemic prevention and control of COVID-19 and promotes the recovery of children with Kawasaki disease and complicated with CAL which is a new model for prevention and control
of COVID-19 with low-risk, low-cost and high-efficiency under severe epidemic situation. Due to the relatively small sample-size and relatively short period of time enrolled in this study, whether this model is worthy of clinical popularization and application
remains to be further studied and confirmed. |
|
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32661139; Broad and Differential Animal Angiotensin-Converting Enzyme 2 Receptor Usage
by SARS-CoV-2 |
Zhao, X, Chen, et al |
Journal of virology |
Epidemiology| Épidémiologie Coronavirology| Coronavirologie Animal model | Modèle animal
zoonoses |
In an effort to search for the potential intermediate or amplifying animal hosts of SARS-CoV-2, we examined receptor
activity of ACE2 from 14 mammal species and found that ACE2s from multiple species can support the infectious entry of lentiviral particles pseudotyped with the wild-type or furin cleavage site-deficient S protein of SARS-CoV-2. ACE2 of human/rhesus monkey
and rat/mouse exhibited the highest and lowest receptor activities, respectively. |
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32641482; LY6E Restricts Entry of Human Coronaviruses, Including Currently Pandemic SARS-CoV-2 |
Zhao, X, Zheng, et al |
Journal of virology |
Coronavirology| Coronavirologie |
We found that LY6E also efficiently restricted the entry mediated by the envelope spike proteins of other human coronaviruses,
including the currently pandemic SARS-CoV-2. The work reported herein thus demonstrates that LY6E is a critical antiviral immune effector that controls CoV infection and pathogenesis via a mechanism distinct from other factors that modulate CoV entry. |
|
Zhao, Y, Guo, et al |
Med Sci Monit |
Public Health response| Interventions de santé publique |
The homeschooling behaviors and feelings of school-age children were assessed with 2010 online surveys obtained separately
from students, parents, and teachers of grades 1-9 in 15 Chinese provinces. We found that 76% of the respondents thought the homeschooling style was acceptable. Students should continue the going-to-school rhythm at home to cope with changes caused by the
COVID-19 pandemic. Integrated grade-specific approaches are needed. Because long screen time and insufficient outdoor activities can severely affect children’s eyesight, appropriate eye-protection measures should be implemented. |
|
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PMC7396968; A Learning-Based Model to Evaluate Hospitalization Priority in COVID-19
Pandemics |
Zheng, Y, Zhu, et al |
Patterns (N Y) |
Epidemiology| Épidémiologie Clinical data| Données cliniques Diagnostics / Pathogen
detection| Diagnostics / Détection d'agents pathogènes |
The emergence of the novel coronavirus disease 2019 (COVID-19) is placing an increasing burden on healthcare systems.
Although the majority of infected patients experience non-severe symptoms and can be managed at home, some individuals develop severe symptoms and require hospital admission. Therefore, it is critical to efficiently assess the severity of COVID-19 and identify
hospitalization priority with precision. In this respect, a four-variable assessment model, including lymphocyte, lactate dehydrogenase, C-reactive protein, and neutrophil, is established and validated using the XGBoost algorithm. This model is found to be
effective in identifying severe COVID-19 cases on admission, with a sensitivity of 84.6%, a specificity of 84.6%, and an accuracy of 100% to predict the disease progression toward rapid deterioration. It also suggests that a computation-derived formula of
clinical measures is practically applicable for healthcare administrators to distribute hospitalization resources to the most needed in epidemics and pandemics. |
|
Zhou, AS, Prince, et al |
Otolaryngology - Head and Neck Surgery (United States) |
Clinical data| Données cliniques Healthcare Response | Réponse des soins de santé |
Objective: The 22-item Sinonasal Outcome Test (SNOT-22) is a trusted measure of symptom severity in chronic rhinosinusitis.
Study Design: Observational outcomes study. Setting: Tertiary care center. Methods: In total, 162 consecutive patients provided a structured sinonasal history Results: In ROC-AUC analyses, SNOT-22 and EPOS-defined symptoms had similar discriminatory capacity
for Lund-Mackay scores, regardless of duration. Within ordinal regression analyses, SNOT-22 nasal scores were significantly associated with Lund-Mackay scores, while EPOS-defined nasal symptoms were not statistically significantly related. Conclusions: SNOT-22
nasal scores and EPOS-defined nasal symptoms may have similar associations with imaging results when assessed via ROC-AUC, while SNOT-22 may have more association within ordinal data. Understanding the implications of discrete patterns of symptoms may confer
benefit, particularly when in-person and fiberoptic exams are limited. |
|
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Clinical analysis of a twin pregnancy woman in close contact with a patient
with suspected COVID-19 |
Zhou, L, Chen, et al |
Chinese Journal of Obstetrics and Gynecology and Pediatrics |
Clinical data| Données cliniques |
In Chinese: Clinical analysis data of this subject were as follows. ①The twin pregnancy with in vitro fertilization-embryo
transfer, without pregnancy-related complications, and without fever, dry cough or other clinical symptoms. ②Epidemiology data: the husband of this subject was a patient with suspected COVID-19. The subject lived in close contact with her husband and did not
take any isolation, disinfection or other protective measures. ③Pregnancy outcomes: after the admission to our hospital, the subject was admitted to a single isolation ward and managed in accordance with the protection standards for COVID-19 suspected patient.
The subject delivered a pair of live twins at 37+ 3 gestational weeks by cesarean section, with birth weights of 2 430 g and 2 510 g, respectively. ④Laboratory examinations and imaging examination results of COVID-19: the subject received chest CT examination
immediately after delivery, and the results showed that there was no obvious abnormality, and the detections of severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) nucleic acid in nasopharynx swab, rectum swab, amniotic fluid and fetal membrane
samples all were negative. |
|
Zhou, X, Yao, et al |
European Journal of Psychotraumatology |
Public Health response| Interventions de santé publique |
The current study sought to examine the underlying mechanisms by which social support relieves ASSs, among primary
and secondary school teachers. A sample of 751 primary and secondary school teachers was selected to answer self-reported questionnaires regarding ASSs, social support, psychological needs, and the sense of control. Structural equation modelling revealed that
social support had a non-significant direct relationship with ASSs, and a significant indirect relationship with reduced ASSs via the needs for autonomy and relatedness, and via the paths from three types of psychological needs to the sense of control. |
|
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COVID-19 and Guillain–Barré Syndrome: A Case Report and Review of Literature |
Zito, A, Alfonsi, et al |
Frontiers in Neurology |
Clinical data| Données cliniques |
We observed a 57-year-old man developing acute motor-sensory axonal neuropathy, a variant of Guillain–Barré syndrome
(GBS), 12 days after severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. |
|
Zou, R, Chen, et al |
Ren Fail |
Epidemiology| Épidémiologie Clinical data| Données cliniques |
Here we report the clinical features of 66 hemodialysis patients with laboratory confirmed COVID-19 infection. Retrospective,
single-center case series of the 66 hemodialysis patients with confirmed COVID-19 from 1 January to 5 March 2020. The incidence of COVID-19 in our center was 11.0% (66/602), of which 18 patients died. According to different prognosis, hemodialysis patients
with COVID-19 were divided into the survival and death group. A higher incidence of fever and dyspnea was found in the death group compared with the survival group. Meanwhile, patients in the death group were often accompanied by higher white blood cell count,
prolonged PT time, increased D-dimer (p < .05). More patients in the death group showed hepatocytes and cardiomyocytes damage. Furthermore, logistic regression analysis suggested that fever, dyspnea, and elevated D-dimer were independent risk factors for death
in hemodialysis patients with COVID-19 (OR, 1.077; 95% CI, 1.014 to 1.439; p = .044; OR, 1.146; 95% CI, 1.026 to 1.875; p = .034, OR, 4.974; 95% CI, 3.315 to 6.263; p = .007, respectively). The potential risk factors of fever, dyspnea, and elevated D-dimer
could help clinicians to identify hemodialysis patients with poor prognosis at an early stage of COVID-19 infection. |
|
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Evaluating e-learning google classroom tools for computer science subjects
during covid-19 pandemic |
Zulkefli, NAM, Hashim, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Public Health response| Interventions de santé publique |
This study aims to evaluate the e-learning Google Classroom as a teaching and learning tool during the COVID-19 pandemic.
A total of 22 Computer Science students at a higher learning institution in Oman enrolled in Computer Programming, Introduction to Database Management System, Network System, Web Development, Operating System, and Management Information System competed in
the study. The study attested that the mean level of challenge faced by students in using Google Classroom is 3.71. Meanwhile, the Pearson correlation test found that the significant value was .000. Therefore, there was a relationship between technical support
for the operating system and social presence aspects. Hence, the null hypothesis (H0) was rejected. |
|
Vital role of chest CT in diagnosis of coronavirus disease 2019 (COVID-19) |
Afshar, ZM, Ebrahimpour, et al |
Caspian Journal of Internal Medicine |
Review Literature| Revue de littérature |
|
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Potential Therapeutic Roles for Direct Factor Xa Inhibitors in Coronavirus Infections |
Al-Horani, R |
Am J Cardiovasc Drugs |
Review Literature| Revue de littérature |
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Alnefaie, A, Albogami, et al |
Saudi Pharmaceutical Journal |
Review Literature| Revue de littérature |
|
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Alturki, SO, Alturki, et al |
Frontiers in Immunology |
Review Literature| Revue de littérature |
|
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32890355; Humor in the Age of COVID-19 Lockdown: An Explorative Qualitative Study |
Amici, P |
Psychiatria Danubina |
Review Literature| Revue de littérature |
|
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Oral Manifestations in Patients with COVID-19: A Living Systematic Review |
Amorim Dos Santos, J, Normando, et al |
J Dent Res |
Review Literature| Revue de littérature |
SR: literature search was conducted in 6 databases and in gray literature. In mild cases, oral mucosal lesions developed
before or at the same time as the initial respiratory symptoms; however, in those who required medication and hospitalization, the lesions developed approximately 7 to 24 d after onset symptoms. Therefore, taste disorders may be common symptoms in patients
with COVID-19 and should be considered in the scope of the disease's onset and progression. |
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An insight on wabāi amrād (Epidemic diseases) and covid-19 like conditions – unani perspective |
Ansari, P, Ahmed, et al |
International Journal of Current Research and Review |
Review Literature| Revue de littérature |
|
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Vitreoretinal surgery in the post-lockdown era: Making the case for combined phacovitrectomy |
Antaki, F, Milad, et al |
Clinical Ophthalmology |
Review Literature| Revue de littérature |
|
|
Aronoff, SC, Hall, et al |
J Pediatric Infect Dis Soc |
Review Literature| Revue de littérature |
SR: Case reports and series of MIS-C were recovered from repeated MEDLINE searches, a single EMBASE search and table
of contents reviews of major general medicine and pediatric journals performed between June 3 and July 23, 2020. MIS-C following SARS-Cov-2 infection frequently presents with gastrointestinal complaints and/or rash; conjunctivitis, chelitis and/or extremity
changes also occur frequently. Serious complications occur frequently and respond to aggressive supportive therapy. |
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Disease, Downturns, and Wellbeing: Economic History and the Long-Run Impacts of COVID-19 |
Arthi, Vellore, Parman, et al |
SSRN- Lancet prepublication |
Review Literature| Revue de littérature |
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Asrani, P, Eapen, et al |
Expert Rev Respir Med |
Review Literature| Revue de littérature |
|
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Au, SCL |
Vis J Emerg Med |
Review Literature| Revue de littérature |
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Azim, AA, Shabbir, et al |
Int Endod J |
Review Literature| Revue de littérature |
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Efficacy of Tocilizumab in COVID-19: A Systematic review and Meta-Analysis |
Aziz, M, Haghbin, et al |
J Med Virol |
Review Literature| Revue de littérature |
SR-MA: literature search of PubMed, Embase, Web of Science, WHO COVID, LitCOVID and Cochrane databases. The addition
of TOC to SOC has the potential to reduce mortality and need for mechanical ventilation in patients with severe COVID-19.
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BaHammam, AS, Bindayna, et al |
Saudi medical journal |
Review Literature| Revue de littérature |
MA: Meta-analytic pooling of the point estimates of death rate per country in the Gulf Cooperation Council countries
was 0.6% (95% CI 0.50% - 0.65%). Wide variability was found between EMR countries in recovery and mortality, implying the possible impact of resource availability, and genetic and environmental factors on the morality and recovery of the COVID-19. |
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Coronavirus disease 2019, school closures, and children’s mental health |
Bahn, GH |
Journal of the Korean Academy of Child and Adolescent Psychiatry |
Review Literature| Revue de littérature |
|
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Barbarossa, L |
Sustainability (Switzerland) |
Review Literature| Revue de littérature |
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Brachytherapy practice during the COVID-19 pandemic: a review on the practice changes |
Barthwal, M, Pareek, et al |
Journal of Contemporary Brachytherapy |
Review Literature| Revue de littérature |
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Bawiskar, D, Phansopkar, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
|
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Review of Current Vaccine Development Strategies to Prevent Coronavirus Disease 2019 (COVID-19) |
Bennet, BM, Wolf, et al |
Toxicol Pathol |
Review Literature| Revue de littérature |
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Bevova, MR, Netesov, et al |
Molecular Genetics, Microbiology and Virology |
Review Literature| Revue de littérature |
|
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Biggerstaff, M, Cowling, et al |
Emerg Infect Dis |
Review Literature| Revue de littérature |
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PMC7245314; Microvascular thrombosis: experimental and clinical implications |
Bray, MA, Sartain, et al |
Transl Res |
Review Literature| Revue de littérature |
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A review: Coronavirus, its types, and impact of covid-19 on global wealth |
Budhrani, AB |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
|
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Neurological aspects of coronavirus infectious disease 2019 (Covid-19) |
Butala, N |
Innovations in Clinical Neuroscience |
Review Literature| Revue de littérature |
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Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection |
Butowt, R, von Bartheld, et al |
Neuroscientist |
Review Literature| Revue de littérature |
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Chaudhari, BV, Chawle, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Covid-19 is a multifaceted challenging pandemic which needs urgent public health interventions |
Contini, C, Caselli, et al |
Microorganisms |
Review Literature| Revue de littérature |
|
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Principles Guiding Nonpandemic
Critical Care Research During a Pandemic |
Cook, DJ, Kho, et al |
Crit Care Med |
Review Literature| Revue de littérature |
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The future is now? Clinical and translational aspects of "Omics" technologies |
D'Adamo, GL, Widdop, et al |
Immunol Cell Biol |
Review Literature| Revue de littérature |
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d'Annunzio, G, Maffeis, et al |
Diabetes research and clinical practice |
Review Literature| Revue de littérature |
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Dawoud, DM, Soliman, et al |
Value in Health |
Review Literature| Revue de littérature |
SR: searched Medline (EBSCOhost), EMBASE (Ovid), EconLit (Ovid), National Health Service Economic Evaluation Database
(Ovid), and Health Technology Assessment (Ovid). The search was last rerun on July 5, 2020. Antiviral treatment for managing pandemics and outbreaks of respiratory illnesses that have very high case fatality rate, similar to COVID-19 pandemic, are likely
to be cost-effective either as a standalone intervention or part of a multifaceted strategy.
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de Assis, GG, Murawska-Cialowicz, et al |
Frontiers in Neurology |
Review Literature| Revue de littérature |
SR: Searches were conducted in PubMed databases from March 30 to April 1, 2020. Results indicate the involvement of
the CNS in infections with various CoVs. Infection typically begins in the airway epithelia with subsequent alveolar involvement, and the virus then spreads to the CNS via neuronal contacts with the recruitment of axonal transport. |
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Delcuve, GP, Lakowski, et al |
IUBMB life |
Review Literature| Revue de littérature |
|
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PMC7476902; COVID-19 pandemic induced stress cardiomyopathy: A literature review |
Desai, HD, Sharma, et al |
Int J Cardiol Heart Vasc |
Review Literature| Revue de littérature |
|
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Deshpande, SB, Parwe, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
|
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Di Maria, E, Latini, et al |
Hum Genomics |
Review Literature| Revue de littérature |
Rapid Review: review encompassing the scientific literature published from Jan. 2003 to June 2020. Studies collecting
large cohorts from different ancestries are needed to further elucidate the role of host genetic variants in determining the response to CoVs infection. |
|
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Review of Ebola virus disease in children–how far have we come? |
Dixit, D, Masumbuko Claude, et al |
Paediatrics and International Child Health |
Review Literature| Revue de littérature |
|
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32880819; Vaccine Against Covid-19 Disease – Present Status of Development |
Dutta, AK |
Indian journal of pediatrics |
Review Literature| Revue de littérature |
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Echelard, JF, Méthot, et al |
JMIR Med Educ |
Review Literature| Revue de littérature |
ScR: Searches were performed on 4 databases, and articles were selected based on the eligibility criteria. Studies
had to be related to the training of medical students in eHealth. The eligibility criteria were studies published since 2014, from a peer-reviewed journal, and written in either English or French |
|
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32876803; Opioid and neuroHIV Comorbidity – Current and Future Perspectives |
Fitting, S, McRae, et al |
Journal of Neuroimmune Pharmacology |
Review Literature| Revue de littérature |
|
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Florez-Perdomo, W, Serrato-Vargas, et al |
Clinical neurology and neurosurgery |
Review Literature| Revue de littérature |
SR-MA: PubMed, Embase, EBSCO Host, Scopus, Science Direct, Medline, and LILACS were searched. The history of cerebrovascular
disease was associated with a 2.78-fold increased risk of mortality compared to patients with other comorbidities or without underlying pathologies. |
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Fong, BYF, Law, et al |
Asia Pacific Journal of Health Management |
Review Literature| Revue de littérature |
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32884218; COVID-19 pandemic: Pathophysiology and manifestations from the gastrointestinal tract |
Galanopoulos, M, Gkeros, et al |
World journal of gastroenterology |
Review Literature| Revue de littérature |
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Gautam, P, Maheshwari, et al |
International Journal of Mathematical, Engineering and Management Sciences |
Review Literature| Revue de littérature |
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Gorenko, JA, Moran, et al |
J Appl Gerontol |
Review Literature| Revue de littérature |
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The Potential Role of Heparin in Patients With COVID-19: Beyond the Anticoagulant Effect. A Review |
Gozzo, L, Viale, et al |
Frontiers in Pharmacology |
Review Literature| Revue de littérature |
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Gross, LZF, Sacerdoti, et al |
ChemMedChem |
Review Literature| Revue de littérature |
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Gudadappanavar, AM, Benni, et al |
J Basic Clin Physiol Pharmacol |
Review Literature| Revue de littérature |
SR:
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'We didn't model that people would go to a party if they tested positive' |
Guglielmi, G |
Nature |
Review Literature| Revue de littérature |
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Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19:Serologic Testing |
Hanson, KE, Caliendo, et al |
Clin Infect Dis |
Review Literature| Revue de littérature |
SR |
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Hasan, SS, Kow, et al |
Am J Cardiovasc Drugs |
Review Literature| Revue de littérature |
SR-MA: systematic literature search in PubMed, Google Scholar, and two preprint repositories (medRxiv and SSRN) without
language restriction up to 19th August 2020. Since there was no increased risk of harm, the use of RAS inhibitors for hypertension and other established clinical indications can be maintained in COVID-19 patients. |
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Hassaballa, Aly Sherif, Ahmed, et al |
Research Square prepub |
Review Literature| Revue de littérature |
SR-MA: CENTRAL, MEDLINE/PubMed, Cochrane Library, and Scopus were systematically searched from inception to May 28,
2020. The study included the largest number of patients with outcome findings of ECMO in this current pandemic. Our findings showed that the use of venovenous ECMO at high-volume ECMO centres may be beneficial for selected COVID 19 patients with severe ARDS. |
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Heath, C, Sommerfield, et al |
Anaesthesia |
Review Literature| Revue de littérature |
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Drug repurposing and cytokine management in response to COVID-19: A review |
Heimfarth, L, Serafini, et al |
International immunopharmacology |
Review Literature| Revue de littérature |
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Heinrich, MA, Martina, et al |
Nano Today |
Review Literature| Revue de littérature |
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Hussain, N, Yoganathan, et al |
Expert Rev Anti Infect Ther |
Review Literature| Revue de littérature |
SR: search was done on Medline, Global Health, and EMBASE using keywords and MeSH terms relevant to COVID- 19 and antivirals.
Limits were put on date to obtain articles between December 2019 to May 2020. Using antivirals in combination with other treatments has potential, however further randomised controlled trials with larger sample sizes are required to identify the best candidate
components that should comprise combined treatments for COVID-19. |
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The coagulopathy, endotheliopathy, and vasculitis of COVID-19 |
Iba, T, Connors, et al |
Inflamm Res |
Review Literature| Revue de littérature |
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Idda, ML, Soru, et al |
Frontiers in Public Health |
Review Literature| Revue de littérature |
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Iyengar, KP, Ish, et al |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
Review Literature| Revue de littérature |
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Jameleddine Chtioui, M, Harzallah, et al |
Tunisie Medicale |
Review Literature| Revue de littérature |
SR: review was performed using Pubmed, Web of Science, INAHTA and GIN databases, from inception to June 4, 2020.
It is recommended to prohibit the use of disinfection booths in all structures.
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A grave situation with COVID in the gravid: A narrative review |
Joshi, K, Acharya, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Possible preventive measures against the spread of covid-19-a review article |
Jotheeswari, P, Yuvaraj, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Anti-inflammatory properties of antidiabetic drugs: A “promised land” in the COVID-19 era? |
Katsiki, N, Ferrannini, et al |
Journal of diabetes and its complications |
Review Literature| Revue de littérature |
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Emerging skin-targeted drug delivery strategies to engineer immunity: A focus on infectious diseases |
Korkmaz, E, Balmert, et al |
Expert Opin Drug Deliv |
Review Literature| Revue de littérature |
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Koshak, DAE, Koshak, et al |
Current Therapeutic Research - Clinical and Experimental |
Review Literature| Revue de littérature |
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Coronavirus: Towards controlling of the pandemic-indian scenario |
Kothari, L, Wadatkar, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Krejčí, J |
Cor et vasa |
Review Literature| Revue de littérature |
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Covid-19 a new global outbreak: Diagnosis, treatment and prevention |
Kumar, A, Goswami, et al |
International Journal of Pharmaceutical Research |
Review Literature| Revue de littérature |
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Kunze, G, Kovacikova, et al |
Notfall und Rettungsmedizin |
Review Literature| Revue de littérature |
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Kurakula, M, Rao, et al |
J Drug Deliv Sci Technol |
Review Literature| Revue de littérature |
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Lee, JC, Nallani, et al |
Am J Rhinol Allergy |
Review Literature| Revue de littérature |
SR: PubMed and Embase were searched from inception through January 31st, 2020. The mechanism of post-viral olfactory
dysfunction is highly complex, virus-dependent, and involves a combination of insults at multiple levels of the olfactory pathway.
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32858069; Household transmission of COVID-19-a systematic review and meta-analysis |
Lei, H, Xu, et al |
Journal of Infection |
Review Literature| Revue de littérature |
SR-MA: PubMed, Embase, and a Chinese database, China National Knowledge Infrastructure (CNKI) on 1 July, 2020. Infection
risk of household contacts is 10 times higher than other contacts. Risk of household transmission in adults is about 3-times higher than that in children. |
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Li Petri, G, Spanò, et al |
European journal of medicinal chemistry |
Review Literature| Revue de littérature |
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Li, Y, Wang, et al |
The Journal of infectious diseases |
Review Literature| Revue de littérature |
SR: searched Medline (Ovid), Embase (Ovid), Global Health (Ovid), Web of Science, and 3 Chinese databases (China National
Knowledge Infrastructure, Wanfang, and Chongqing VIP) for studies published between 1 January 1990 and 15 April 2020. This is the first study that provides an overview of the global seasonality of sCoVs. Our findings offer clues to the possible postpandemic
circulating season of SARS-CoV-2 and add to the knowledge pool necessary for postpandemic preparedness for SARS-CoV-2. |
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Liu, T, Gong, et al |
International Journal of Infectious Diseases |
Review Literature| Revue de littérature |
The SARS-CoV-2 can be transmitted in various circumstances, and cluster infections play an important role in the rapid
evolution of COVID-19 transmission. Prevention and control measures such as social distancing must be strictly implemented to contain these cluster infections. The SARS-CoV-2 can be transmitted in various circumstances, and cluster infections play an important
role in the rapid evolution of COVID-19 transmission. Prevention and control measures such as social distancing must be strictly implemented to contain these cluster infections.
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Liu, Y, Wu, et al |
Journal of the American Heart Association |
Review Literature| Revue de littérature |
SR-MA: Relevant reports updated to April 17, 2020, were searched from PubMed, Embase, Web of Science, and the Cochrane
Library with no restriction on language. The prevalence of cardiovascular comorbidities varies among different coronavirus-associated diseases. With the development of time, proportions of cardiovascular comorbidities in COVID-19 need further attention. |
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Coronavirus disease (COVID) 2019 in children – A short review |
Lohiya, SB, Damke, et al |
International Journal of Current Research and Review |
Review Literature| Revue de littérature |
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Unfolding the future: Self-controlled catalytic nanomotor in healthcare system |
Londhe, V, Sharma, et al |
Mater Sci Eng C Mater Biol Appl |
Review Literature| Revue de littérature |
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Loo, SKF, Hon, et al |
Drugs in Context |
Review Literature| Revue de littérature |
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Abdominal imaging findings in patients with SARS-CoV-2 infection: a scoping review |
Lui, K, Wilson, et al |
Abdom Radiol (NY) |
Review Literature| Revue de littérature |
ScR: review of MEDLINE, EMBASE, SCOPUS, and Web of Science was performed from inception to July 15, 2020 using PRISMA-ScR
guidelines. Gastrointestinal manifestations and imaging manifestations of SARS-CoV-2 infection are increasingly reported and warrant specific attention during abdominal imaging. |
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Lyadova, IV, Staricov, et al |
Russian Journal of Infection and Immunity |
Review Literature| Revue de littérature |
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Manolis, AS, Manolis, et al |
J Cardiovasc Pharmacol Ther |
Review Literature| Revue de littérature |
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Mansouri, K, Rastegari-Pouyani, et al |
Biomedicine and Pharmacotherapy |
Review Literature| Revue de littérature |
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Marson, FAL |
Diagn Microbiol Infect Dis |
Review Literature| Revue de littérature |
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Essential and Vulnerable: Implications of Covid-19 for Farmers in Ireland |
Meredith, D, McNamara, et al |
J Agromedicine |
Review Literature| Revue de littérature |
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Milovanović, A, Kostić, et al |
Sustainability (Switzerland) |
Review Literature| Revue de littérature |
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Beyond point of care diagnostics: Low-dimensional nanomaterials for electronic virus sensing |
Muratore, C, Muratore, et al |
Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films |
Review Literature| Revue de littérature |
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Nagoba, B, Gavkare, et al |
Journal of Infection and Public Health |
Review Literature| Revue de littérature |
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Neil, D, Moran, et al |
J Pathol |
Review Literature| Revue de littérature |
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Nieto-Benito, L, Hernández de la Torre-Ruiz, et al |
Australas J Dermatol |
Review Literature| Revue de littérature |
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Pediatric Lung Imaging Features of Covid-19: A Systematic Review and Meta-Analysis |
Nino, G, Zember, et al |
Pediatr Pulmonol |
Review Literature| Revue de littérature |
SR-MA: search of PubMed was performed. Chest CT manifestations in children with COVID-19 could potentially be used
for early identification and prompt intervention in the pediatric population.
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Nisargandha, MA, Dadaraoparwe, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis |
Noor, FM, Islam, et al |
J Community Health |
Review Literature| Revue de littérature |
MA: Three electronic databases including PubMed, Science Direct and Google Scholar were searched to identify relevant
cohort studies of COVID-19 disease from January 1, 2020, to August 11, 2020. This meta-analysis revealed that the mortality rate among COVID-19 patients was highest in the European region and older age, gender, ICU patients, patients with comorbidity had a
high risk for case fatality. |
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Nursalam, N, Sukartini, et al |
Systematic Reviews in Pharmacy |
Review Literature| Revue de littérature |
SR: searched five electronic databases (Scopus, PubMed, Science Direct, CINAHL and ProQuest) for previous studies using
a cross-sectional or quasi-experimental design published between March and April 2020. The factors contributed in psychology and social stigma studies are mostly quasi-experiment and cross-sectional. The average number of participants were more than one thousand
overall for every study and discussed psychological impact and social stigma related factors. Factors contributing to psychological impact were age, gender, education background, economic, support system, health condition and source information., whilst factors
contributing to social stigma were environmental, history of accompanying chronic diseases, discrimination, self-isolation and people's perceptions of the affected area.
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A bibliometric analysis of COVID-19 research published in nursing journals |
Oh, J, Kim, et al |
Science Editing |
Review Literature| Revue de littérature |
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Therapeutics for COVID-19: from computation to practices—where we are, where we are heading to |
Ojha, PK, Kar, et al |
Molecular diversity |
Review Literature| Revue de littérature |
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O'Reilly, A, Tibbs, et al |
Ir J Psychol Med |
Review Literature| Revue de littérature |
Rapid Review: review of the published peer-reviewed literature, published between 1985 and 2020, using PsycINFO (Proquest)
and Medline (Proquest) was conducted. More longitudinal research with young people, particularly adolescents in the general population, before and during the early stages of an infectious disease outbreak is needed to obtain a clear understanding of how best
to support young people during these events. |
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Re-positive coronavirus disease 2019 PCR test: could it be a reinfection? |
Osman, AA, Al Daajani, et al |
New Microbes and New Infections |
Review Literature| Revue de littérature |
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32876633; Impact of COVID-19 on liver disease and the public health in Peru |
Padilla Machaca, PM, Cárdenas Ramírez, et al |
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru |
Review Literature| Revue de littérature |
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Peng, S, Chen, et al |
Science of the Total Environment |
Review Literature| Revue de littérature |
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Perna, G, Cuniberti, et al |
Journal of affective disorders |
Review Literature| Revue de littérature |
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Musculoskeletal check in smartphone overuse in covid 19 lockdown phase |
Phansopkar, P, Naqvi, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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32866437; Immune response in SARS-CoV-2 infection: the role of interferons type I and type III |
Portela Sousa, C, Brites, et al |
Brazilian Journal of Infectious Diseases |
Review Literature| Revue de littérature |
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Radanliev, Petar, De Roure, et al |
arXiv |
Review Literature| Revue de littérature |
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Radanliev, Petar, De Roure, et al |
arXiv |
Review Literature| Revue de littérature |
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Utility of vaccination adopted in india forchildren to fight against COVID-19 |
Rana, N, Borage, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Global sourcing strategies: A framework for lean, agile, and leagile |
Rashad, W, Nedelko, et al |
Sustainability (Switzerland) |
Review Literature| Revue de littérature |
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Reche, A, Kolse, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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32878619; COVID-19 length of hospital stay: a systematic review and data synthesis |
Rees, EM, Nightingale, et al |
BMC medicine |
Review Literature| Revue de littérature |
SR: searched the bibliographic databases Embase and Medline, as well as the online pre-print archive medRxiv and included
articles published up to 12 April 2020. Patients with COVID-19 in China appeared to remain in hospital for longer than elsewhere. This may be explained by differences in criteria for admission and discharge between countries, and different timing within the
pandemic. |
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Rife, E, Gedalia, et al |
Curr Rheumatol Rep |
Review Literature| Revue de littérature |
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Roberge, RJ, Roberge, et al |
Disaster Med Public Health Prep |
Review Literature| Revue de littérature |
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Roselin, C, Parameshwari, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Rouf, R, Uddin, et al |
Trends Food Sci Technol |
Review Literature| Revue de littérature |
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Sani, I, Hamza, et al |
Annals of Medicine and Surgery |
Review Literature| Revue de littérature |
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Sarda, SR, Tekale, et al |
European Chemical Bulletin |
Review Literature| Revue de littérature |
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Cyber risk in health facilities: A systematic literature review |
Sardi, A, Rizzi, et al |
Sustainability (Switzerland) |
Review Literature| Revue de littérature |
SR
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Shaaban, AN, Peleteiro, et al |
Frontiers in Public Health |
Review Literature| Revue de littérature |
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Sharma, A, Sinha, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Sharps, MC, Hayes, et al |
Placenta |
Review Literature| Revue de littérature |
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Shchelkanov, MY, Kolobukhina, et al |
Russian Journal of Infection and Immunity |
Review Literature| Revue de littérature |
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Shimpi, T, Kulkarni, et al |
European Journal of Radiology Open |
Review Literature| Revue de littérature |
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Druggable targets from coronaviruses for designing new antiviral drugs |
Silva, LR, da Silva Santos-Júnior, et al |
Bioorganic and Medicinal Chemistry |
Review Literature| Revue de littérature |
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32791222; Economic Impact of COVID-19 on a High-Volume Academic Neurosurgical Practice |
Sivakanthan, S, Pan, et al |
World Neurosurgery |
Review Literature| Revue de littérature |
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SOME OPPORTUNITIES for IMMUNOTHERAPY in CORONAVIRUS INFECTION |
Smirnov, VS, Totolian Areg, et al |
Russian Journal of Infection and Immunity |
Review Literature| Revue de littérature |
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From Bad to Worse: The Impact of COVID-19 on Commercial Fisheries Workers |
Sorensen, J, Echard, et al |
J Agromedicine |
Review Literature| Revue de littérature |
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Impact of COVID-19 on the Cardiovascular System: A Review of Available Reports |
Soumya, RS, Unni, et al |
Cardiovasc Drugs Ther |
Review Literature| Revue de littérature |
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Suri, JS, Puvvula, et al |
Computers in biology and medicine |
Review Literature| Revue de littérature |
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Taffarel, P, Jorro Barón, et al |
Arch Argent Pediatr |
Review Literature| Revue de littérature |
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Tajbakhsh, A, Gheibi Hayat, et al |
Expert Rev Anti Infect Ther |
Review Literature| Revue de littérature |
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THE ROLES of VILLAGE HEALTH VOLUNTEERS: COVID-19 PREVENTION and CONTROL in THAILAND |
Tejativaddhana, P, Suriyawongpaisal, et al |
Asia Pacific Journal of Health Management |
Review Literature| Revue de littérature |
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Tilocca, B, Britti, et al |
J Proteome Res |
Review Literature| Revue de littérature |
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Novel β-Coronavirus (SARS-CoV-2): Current and future aspects of pharmacological treatments |
Tiwari, N, Upadhyay, et al |
Saudi Pharmaceutical Journal |
Review Literature| Revue de littérature |
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Diabetes and COVID-19: A pooled analysis related to disease severity and mortality |
Varikasuvu, SR, Dutt, et al |
Primary Care Diabetes |
Review Literature| Revue de littérature |
MA: COVID-19 patients with diabetes have a significantly higher risk of disease severity (OR = 2.20, 95% CI = 1.69–2.86,
p < 0.00001) and associated mortality outcomes (OR = 2.52, 95% CI = 1.93–3.30, p = < 0.00001).
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Varvařovský, I, Mates, et al |
Cor et vasa |
Review Literature| Revue de littérature |
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Adaptive nutrients in strengthening the immune and respiratory system concerning COVID 19 |
Venipriyadharshini, L |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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COVID-19 and its Therapeutics: Special Emphasis on Mesenchymal Stem Cells Based Therapy |
Verma, YK, Verma, et al |
Stem Cell Rev Rep |
Review Literature| Revue de littérature |
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Vitamin D Deficiency In Schizophrenia-Implications For COVID-19 Infection |
Viani-Walsh, D, Kennedy-Williams, et al |
Ir J Psychol Med |
Review Literature| Revue de littérature |
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Vinusha, HM, Shivamallu, et al |
International Journal of Research in Pharmaceutical Sciences |
Review Literature| Revue de littérature |
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Wan, S, Liu, et al |
Kexue Tongbao/Chinese Science Bulletin |
Review Literature| Revue de littérature |
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GS-5734: A potentially approved drug by FDA against SARS-Cov-2 |
Wang, Z, Yang, et al |
New Journal of Chemistry |
Review Literature| Revue de littérature |
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Wen, Z, Li, et al |
Chinese Journal of Microbiology and Immunology (China) |
Review Literature| Revue de littérature |
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COVID-19 Neurological Manifestations and Underlying Mechanisms: A Scoping Review |
Wenting, A, Gruters, et al |
Frontiers in Psychiatry |
Review Literature| Revue de littérature |
ScR: searches in PubMed, PsycInfo, and CINAHL databases. Full text articles in English were included if they involved
humans with COVID-19. The search was updated twice, the latest on 19 May 2020. Neurological manifestations of COVID-19 vary from mild (e.g. loss of taste and smell, dizziness, headache) to severe (e.g. ischemic stroke, encephalitis). Underlying pathways are
suggested to be both indirect (as a result of thrombotic complication, inflammatory consequences, hypoxia, blood pressure dysregulation), and direct (neurotropic properties of the virus). |
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White, A |
Postgrad Med |
Review Literature| Revue de littérature |
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Multisystem effects of COVID-19: A concise review for practitioners |
White-Dzuro, G, Gibson, et al |
Postgrad Med |
Review Literature| Revue de littérature |
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A review on novel drug targets and future directions for COVID-19 treatment |
Wondmkun, YT, Mohammed, et al |
Biologics: Targets and Therapy |
Review Literature| Revue de littérature |
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Wu, X, Liu, et al |
Ann Med |
Review Literature| Revue de littérature |
SR-MA: search included all relevant studies published prior to 1 April 2020. Our findings offer guidance for a wide
spectrum of clinicians to early identify severe COVID-19 patients, transport to specialised centres, and initiate appropriate treatment. |
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Xing, Y, Liu, et al |
Kexue Tongbao/Chinese Science Bulletin |
Review Literature| Revue de littérature |
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Xu, W, Wu, et al |
Health Policy and Technology |
Review Literature| Revue de littérature |
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Yada, SS, Sinha, et al |
Journal of Critical Reviews |
Review Literature| Revue de littérature |
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Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis |
Yamakawa, M, Kuno, et al |
Journal of Stroke and Cerebrovascular Diseases |
Review Literature| Revue de littérature |
SR-MA: PubMed and EMBASE were searched on June 10, 2020. The frequency of detected stroke in hospitalized COVID-19
patients was 1.1% and associated with older age and stroke risk factors. Frequent cryptogenic stroke and elevated d-dimer level support increased risk of thromboembolism in COVID-19 associated with high mortality. |
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Current Status of COVID-19 (Pre)Clinical Vaccine Development |
Ye, T, Zhong, et al |
Angewandte Chemie |
Review Literature| Revue de littérature |
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Zahedi Niaki, O, Anadkat, et al |
J Am Acad Dermatol |
Review Literature| Revue de littérature |
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Zaichuk, TA, Nechipurenko, et al |
Molecular biology |
Review Literature| Revue de littérature |
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Zeng, M, Li, et al |
PLoS One |
Review Literature| Revue de littérature |
SR-MA: searched seven databases and retrieved the Chinese Journal Full-text Database (CNKI), Vip Database (VIP), China
Biomedicine (SinoMed), Wanfang Database and PubMed, Cochrane Central, EMBASE from October 2019 to May 2020. The treatment of new pneumonia with traditional Chinese medicine lotus clearing plague can be used as an effective therapy to improve the clinical symptoms
of new coronary pneumonia. |
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An Overview of the Temporal Shedding of SARS-CoV-2 RNA in Clinical Specimens |
Zhurakivska, K, Troiano, et al |
Frontiers in Public Health |
Review Literature| Revue de littérature |
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Cardiac Injury and COVID-19: A Systematic Review and Meta-analysis |
Zou, F, Qian, et al |
CJC Open |
Review Literature| Revue de littérature |
SR-MA: searched PubMed and Embase and was limited to Chinese and English and all articles from January 1, 2020 to May
30, 2020 were reviewed. Cardiac injury is common in hospitalized COVID-19 patients and is significantly associated with mortality. Patients who were older with hypertension and chronic obstructive respiratory disease were prone to develop cardiac injury. |
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Ab Rahman, Z, Kashim, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Ab Rahman, Z, Kashim, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Ab Rahman, Z, Mohd Noor, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Ab Rahman, Z, Mohd Noor, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Abdelmaksoud, A, Goldust, et al |
Dermatologic Therapy |
Commentary/Editorial| Commentaire/Éditorial |
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32779768; Generalized status epilepticus as a possible manifestation of COVID-19 |
Abdulsalam, MA, Abdulsalam, et al |
Acta Neurologica Scandinavica |
Commentary/Editorial| Commentaire/Éditorial |
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Abi Fadel, F, Al-Jaghbeer, et al |
Anaesthesiology intensive therapy |
Commentary/Editorial| Commentaire/Éditorial |
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Exacerbation of chronic inflammatory demyelinating polyneuropathy in concomitance with COVID-19 |
Abu-Rumeileh, S, Garibashvili, et al |
Journal of the neurological sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Acar, T, Demirel, et al |
Turk Noroloji Dergisi |
Commentary/Editorial| Commentaire/Éditorial |
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32893646; How to deal and learn from the threat of COVID-19 in paediatric dentistry |
Acharya, S, Singh, et al |
European journal of paediatric dentistry |
Commentary/Editorial| Commentaire/Éditorial |
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Global health research partnerships in the context of the Sustainable Development Goals (SDGs) |
Addo-Atuah, J, Senhaji-Tomza, et al |
Research in Social and Administrative Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
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Ademola-Popoola, D, Lloyd, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Adiwinata Pawitan, J |
Transfusion and Apheresis Science |
Commentary/Editorial| Commentaire/Éditorial |
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Adyel, TM |
Science |
Commentary/Editorial| Commentaire/Éditorial |
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Lopinavir-Ritonavir in SARS-CoV-2 Infection and Drug-Drug Interactions with Cardioactive Medications |
Agarwal, S, Agarwal, et al |
Cardiovasc Drugs Ther |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7405880; Liver abnormality may develop cerebral vein thrombosis in COVID-19 |
Aghayari Sheikh Neshin, S, Basirjafari, et al |
J Neurol Sci |
Commentary/Editorial| Commentaire/Éditorial |
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Agius, R |
Occup Med (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
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The successful management of an elderly Covid-19 infected patient by plasmapheresis |
Akkoyunlu, Y, Cetin, et al |
Transfusion and Apheresis Science |
Commentary/Editorial| Commentaire/Éditorial |
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Olfactory dysfunction may predict myocardial injury in COVID-19 patients |
Akşit, E, Çil, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Emergency Surgery During COVID-19 Pandemic; What Has Changed in Practice? |
Alimoglu, O, Erol, et al |
Br J Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Altayb, HN, Altayeb, et al |
New Microbes and New Infections |
Commentary/Editorial| Commentaire/Éditorial |
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Dornase alfa in the treatment of COVID-19: Destruction of neutrophil extracellular traps |
Amelina, EL, Kashirskaya, et al |
Pulmonologiya |
Commentary/Editorial| Commentaire/Éditorial |
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Andhare, R, Muley, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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André, JC |
Environnement, Risques et Sante |
Commentary/Editorial| Commentaire/Éditorial |
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Angrup, A, Kanaujia, et al |
Indian journal of medical microbiology |
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Angurana, SK, Bansal, et al |
Br J Nutr |
Commentary/Editorial| Commentaire/Éditorial |
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Positive aspects of covid 19 pandemic: A blessing in disguise |
Anjankar Ashish, P, Anjankar Vaibhav, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Antiel, RM, Curlin, et al |
Pediatrics |
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Arslan, M, Xu, et al |
Sci Total Environ |
Commentary/Editorial| Commentaire/Éditorial |
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Arun Babu, T, Sharmila, et al |
European Journal of Obstetrics and Gynecology and Reproductive Biology |
Commentary/Editorial| Commentaire/Éditorial |
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Aschermann, M |
Cor et vasa |
Commentary/Editorial| Commentaire/Éditorial |
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Asensio-Samper, J, Rubio-Haro, et al |
Revista espanola de anestesiologia y reanimacion |
Commentary/Editorial| Commentaire/Éditorial |
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Asserraji, M, Maoujoud, et al |
Journal of Nephropathology |
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Atherly, A, Van Den Broek-Altenburg, et al |
JMIR Public Health Surveill |
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The Urgent and Growing Needs of Youths Experiencing Homelessness During the COVID-19 Pandemic |
Auerswald, CL, Adams, et al |
Journal of Adolescent Health |
Commentary/Editorial| Commentaire/Éditorial |
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Degradation and disease: Ecologically unequal exchanges cultivate emerging pandemics |
Austin, KF |
World Development |
Commentary/Editorial| Commentaire/Éditorial |
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Ayache, S, Schmerber, et al |
Otol Neurotol |
Commentary/Editorial| Commentaire/Éditorial |
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Aziz, NA, Othman, et al |
Journal of Infection and Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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The Importance of Proper Use of N95 Respirators by Health-Care Workers |
Azizi, TH, Varasteh, et al |
Creat Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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Azra, MN |
International Journal of Current Research and Review |
Commentary/Editorial| Commentaire/Éditorial |
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Babata, KL, Yeo, et al |
Cochrane Database of Systematic Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Bahn, GH |
Journal of the Korean Academy of Child and Adolescent Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Dancing With Death in the Dust of Coronavirus: The Lived Experience of Iranian Nurses |
Bahramnezhad, F, Asgari, et al |
Creat Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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Balasubramanian, M, Balakrishnan, et al |
International Journal of Pharmaceutical Research |
Commentary/Editorial| Commentaire/Éditorial |
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Banks, LM, Davey, et al |
World Development |
Commentary/Editorial| Commentaire/Éditorial |
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Reaching out to slum dwellers to address starvation during the 2020 pandemic in India |
Banshkar, A, Vinzuda, et al |
Social Work with Groups |
Commentary/Editorial| Commentaire/Éditorial |
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Bantman, P |
Information Psychiatrique |
Commentary/Editorial| Commentaire/Éditorial |
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Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease |
Barrett, TJ, Lee, et al |
Circ Res |
Commentary/Editorial| Commentaire/Éditorial |
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Barry, H, Doherty, et al |
Ir J Psychol Med |
Commentary/Editorial| Commentaire/Éditorial |
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Is Surgical Tracheostomy Better Than Percutaneous Tracheostomy in COVID-19-Positive Patients? |
Bassi, M, Ruberto, et al |
Anesth Analg |
Commentary/Editorial| Commentaire/Éditorial |
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Baugstø, V |
Tidsskrift for den Norske laegeforening |
Commentary/Editorial| Commentaire/Éditorial |
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Bautista, CA, Huang, et al |
J Interprof Care |
Commentary/Editorial| Commentaire/Éditorial |
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Rugged Individualism and Collective (In)Action During the COVID-19 Pandemic |
Bazzi, Samuel, Fiszbein, et al |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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Teaching Online Physical Education: The Art of Connection in the Digital Classroom |
Beard, J, Konukman, et al |
Journal of Physical Education, Recreation and Dance |
Commentary/Editorial| Commentaire/Éditorial |
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Beck, N |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Bioanalysis |
Commentary/Editorial| Commentaire/Éditorial |
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Becot, F, Inwood, et al |
J Agromedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Beneš, J |
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Commentary/Editorial| Commentaire/Éditorial |
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Arranging an emergency Vascular Accesses Program during COVID-19 pandemic |
Benvenuti, S, Parolini, et al |
J Vasc Access |
Commentary/Editorial| Commentaire/Éditorial |
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Social media and covid-19 thank you to pharmacy staff on the front lines |
Berger, K |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Smart healthcare system for COVID-19 using internet of things |
Bharathi, N, Sriramya, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Subcellular hot spots of GPCR signaling promote vascular inflammation |
Birch, CA, Molinar-Inglis, et al |
Current Opinion in Endocrine and Metabolic Research |
Commentary/Editorial| Commentaire/Éditorial |
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Underreporting COVID-19: The curious case of lower-income countries |
Biswas, RK, Afiaz, et al |
Epidemiol Infect |
Commentary/Editorial| Commentaire/Éditorial |
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Blank, C |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Bonny, A, Talle, et al |
Travel Medicine and Infectious Disease |
Commentary/Editorial| Commentaire/Éditorial |
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Therapeutic strategies of COVID-19: From natural compounds to vaccine trials |
Bouyahya, A, Omari, et al |
Biointerface Research in Applied Chemistry |
Commentary/Editorial| Commentaire/Éditorial |
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Editorial: Evidence on APRA Proposals and Impact of COVID-19 on Expected Credit Loss Accounting |
Bradbury, M, Howieson, et al |
Australian Accounting Review |
Commentary/Editorial| Commentaire/Éditorial |
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Bremmer, I |
Finance and Development |
Commentary/Editorial| Commentaire/Éditorial |
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IBD in the COVID-19 era: the value of international collaboration |
Brenner, EricaJ, Ungaro, et al |
The Lancet Gastroenterology & Hepatology |
Commentary/Editorial| Commentaire/Éditorial |
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Increased Childhood Peripheral Facial Palsy in the Emergency Department During COVID-19 Pandemic |
Brisca, G, Garbarino, et al |
Pediatr Emerg Care |
Commentary/Editorial| Commentaire/Éditorial |
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Psihoterapija |
Commentary/Editorial| Commentaire/Éditorial |
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Group therapy during a pandemic caused by new coronavirus (SARS-COV-2) |
Brkić, M |
Psihoterapija |
Commentary/Editorial| Commentaire/Éditorial |
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Measuring measurement – What is metrology and why does it matter? |
Brown, RJC |
Measurement: Journal of the International Measurement Confederation |
Commentary/Editorial| Commentaire/Éditorial |
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Deutsche Apotheker Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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Cosa stiamo imparando dalla pandemia da covid-19: Il presente e il futuro |
Brunelli, A |
Medico e Bambino |
Commentary/Editorial| Commentaire/Éditorial |
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32682813; Microthrombosis associated with GI bleeding in COVID-19 |
Buckholz, A, Kaplan, et al |
Gastrointestinal endoscopy |
Commentary/Editorial| Commentaire/Éditorial |
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Can intravenous oxytocin infusion counteract hyperinflammation in COVID-19 infected patients? |
Buemann, B, Marazziti, et al |
World J Biol Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7287419; Recreational waters - A potential transmission route for SARS-CoV-2 to humans? |
Cahill, N, Morris, et al |
Sci Total Environ |
Commentary/Editorial| Commentaire/Éditorial |
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Vitamin D to prevent COVID-19: recommendations for the design of clinical trials |
Camargo, CA, J, et al |
FEBS Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Cammarata-Scalisi, F, Cárdenas Tadich, et al |
Arch Argent Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Campbell, LH |
Journal of Telecommunications and the Digital Economy |
Commentary/Editorial| Commentaire/Éditorial |
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Structural vulnerability to COVID-19 among Latinx communities in the United States |
Cantos, VD, Rebolledo, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Capone, A |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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A atuação do dentista de família: Na pandemia do covid-19: O cenário do Rio de Janeiro |
Carletto, AF, Santos, et al |
Physis |
Commentary/Editorial| Commentaire/Éditorial |
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Caruso, N, Mela, et al |
Urban Research and Practice |
Commentary/Editorial| Commentaire/Éditorial |
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Casale, M, Imbalzano, et al |
Cor et vasa |
Commentary/Editorial| Commentaire/Éditorial |
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Pharmaceutical nanotechnology: which products are been designed against COVID-19? |
Cavalcanti, IDL, Cajubá de Britto Lira Nogueira, et al |
Journal of Nanoparticle Research |
Commentary/Editorial| Commentaire/Éditorial |
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32866405; Web Exclusive. Annals On Call - Regulatory T Cells: Treatment for COVID-19? |
Centor, RM, D'Alessio, et al |
Annals of Internal Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Optimal delivery management for the prevention of early neonatal SARS-CoV-2 infection |
Chan, CS, Kong, et al |
Cochrane Database of Systematic Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7188164; A Case Series of Children With Coronavirus Disease 2019: What Have We Learned? |
Chan, JF, To, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Chan, MC, Yeo, et al |
Eur Urol |
Commentary/Editorial| Commentaire/Éditorial |
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Chang, EH, Willis, et al |
American journal of respiratory and critical care medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Overall management strategies for colorectal cancer patients during the COVID-19 outbreak |
Chang, W, Feng, et al |
Chinese Journal of Digestive Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Chardavoyne, P, Olympia, et al |
NASN Sch Nurse |
Commentary/Editorial| Commentaire/Éditorial |
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A Cytometrist's Guide to Coordinating and Performing Effective COVID-19 Research |
Chattopadhyay, PK, Filby, et al |
Cytometry Part A |
Commentary/Editorial| Commentaire/Éditorial |
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Lessons to Learn From a Successful Virtual Mock Oral Examination Pilot Experience |
Chaurasia, AR, Page, et al |
Advances in Radiation Oncology |
Commentary/Editorial| Commentaire/Éditorial |
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How Fragmentation Can Undermine the Public Health Response to COVID-19 |
Chen, Andrew Tzer-Yeu |
arXiv |
Commentary/Editorial| Commentaire/Éditorial |
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Chen, J, Yang, et al |
Chinese Journal of Digestive Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Education in the post-pandemic era: Indigenous children and youth |
Cherubini, L |
International Indigenous Policy Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Chien, LC, Beÿ, et al |
Disaster Med Public Health Prep |
Commentary/Editorial| Commentaire/Éditorial |
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Expert consensus on overall management of gastric cancer during the COVID-19 outbreak |
China Gastrointestinal Cancer Surgery, Union |
Chinese Journal of Digestive Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Chinese Medical Doctor, Association, Chinese Research Hospital Association Society for Hepato-Pancreato-Biliary, et al |
Chinese Journal of Digestive Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Multicenter interim guidance on use of antivirals
for children with COVID-19/SARS-CoV-2 |
Chiotos, K, Hayes, et al |
J Pediatric Infect Dis Soc |
Commentary/Editorial| Commentaire/Éditorial |
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Promotion of Maternal–Infant Mental Health and Trauma-Informed Care During the COVID-19 Pandemic |
Choi, KR, Records, et al |
JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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QC
corner: Upholding biosafety standards despite the acute need for a SARS-CoV-2 vaccine |
Chollet, R, Galbraith, et al |
American Pharmaceutical Review |
Commentary/Editorial| Commentaire/Éditorial |
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Update Alert 4: Epidemiology of and Risk Factors for Coronavirus Infection in Health Care Workers |
Chou, R, Dana, et al |
Ann Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Chou, R, Dana, et al |
Annals of Internal Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Serological assays for delayed SARS-CoV-2 case identification |
Choy, Kay Weng |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Cirri, D, Pratesi, et al |
Expert Opin Drug Discov |
Commentary/Editorial| Commentaire/Éditorial |
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There are no shortcuts in the development and validation of a covid-19 prediction model |
Collins, GS, Ma, et al |
Transbound Emerg Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Crowley, J, Raz, et al |
Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Delay or Avoidance of Medical Care Because of COVID-19-Related Concerns - United States, June 2020 |
Czeisler, MÉ, Marynak, et al |
MMWR Morb Mortal Wkly Rep |
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Dabachine, Y, Taheri, et al |
J Air Transp Manag |
Commentary/Editorial| Commentaire/Éditorial |
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Eur J Clin Invest |
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Das, D, Datta, et al |
Asia Pacific Journal of Health Management |
Commentary/Editorial| Commentaire/Éditorial |
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Premises among SARS-CoV-2, dysbiosis and diarrhea: Walking through the ACE2/mTOR/autophagy route |
de Oliveira, AP, Lopes, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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de Vroege, L, Gribling, et al |
Tijdschrift voor Psychiatrie |
Commentary/Editorial| Commentaire/Éditorial |
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On Pandemic Preparedness: How Well is the Modeling Community Prepared for COVID-19? |
Desai, K, Druyts, et al |
PharmacoEconomics |
Commentary/Editorial| Commentaire/Éditorial |
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Dettmeyer, R, Lasczkowski, et al |
Rechtsmedizin |
Commentary/Editorial| Commentaire/Éditorial |
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Devulapalli, CS |
Tidsskrift for den Norske laegeforening |
Commentary/Editorial| Commentaire/Éditorial |
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Announcing the winners of our COVID-19 Creative Communication Competition |
Dhillon, P |
FEBS Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Telelactation: A Necessary Skill With Puppet Adjuncts During the COVID-19 Pandemic |
Dhillon, S, Dhillon, et al |
J Hum Lact |
Commentary/Editorial| Commentaire/Éditorial |
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Pushing the envelope: The who, what, when, and why of critical consciousness |
Diemer, MA |
Journal of Applied Developmental Psychology |
Commentary/Editorial| Commentaire/Éditorial |
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Diringer, E, Perciasepe, et al |
Bulletin of the Atomic Scientists |
Commentary/Editorial| Commentaire/Éditorial |
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Fortification is required in the rear to win the battle of epidemic prevention and
control |
Dong, J, Feng, et al |
Chinese Journal of Digestive Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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The Multiple Faces of Heparin: Opportunities in COVID-19 Infection and Beyond |
Drouet, L, Harenberg, et al |
Thromb Haemost |
Commentary/Editorial| Commentaire/Éditorial |
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D'Silva, KM, Serling-Boyd, et al |
Annals of the Rheumatic Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Eaton, J |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 as social disability: The opportunity of social empathy for empowerment |
Ebuenyi, ID, Smith, et al |
BMJ Global Health |
Commentary/Editorial| Commentaire/Éditorial |
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What Are the Odds of Finding a COVID-19 Drug from a Lab Repurposing Screen? |
Edwards, A |
J Chem Inf Model |
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Alimentary Pharmacology and Therapeutics |
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Zithromax® donation for trachoma
elimination during the COVID-19 pandemic |
Emerson, P, Hooper, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Estelles, M, Fischman, et al |
Praxis Educativa |
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Farmaki, A, Miguel, et al |
Int J Hosp Manag |
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Low glycosylated ferritin is a sensitive biomarker of severe COVID-19 |
Fauter, M, Viel, et al |
Cell Mol Immunol |
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Feng, Z, Savani, et al |
Gender in Management |
Commentary/Editorial| Commentaire/Éditorial |
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Ferguson, K, Johnston, et al |
Anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Fernandes Cabral, DT, Alan, et al |
World Neurosurgery |
Commentary/Editorial| Commentaire/Éditorial |
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Fernandes, L, Ortega, et al |
Physis |
Commentary/Editorial| Commentaire/Éditorial |
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Fernandes, N |
Acta Medica Portuguesa |
Commentary/Editorial| Commentaire/Éditorial |
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Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19? |
Feyaerts, AF, Luyten, et al |
Nutrition |
Commentary/Editorial| Commentaire/Éditorial |
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A note on blind contact tracing at scale with applications to the COVID-19 pandemic |
Fitzsimons, JK, Mantri, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Drugs, clinical
trials and registers in the times of the coronavirus Emergency |
Fontana, M, Zuin, et al |
Medico e Bambino |
Commentary/Editorial| Commentaire/Éditorial |
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Formiga, F, Tarazona-Santabalbina, et al |
Revista Espanola de Geriatria y Gerontologia |
Commentary/Editorial| Commentaire/Éditorial |
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Freckelton Qc, I |
International journal of law and psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Loneliness and Its Concomitants among Older Adults during the COVID-19 Pandemic |
Frenkel-Yosef, M, Maytles, et al |
Int Psychogeriatr |
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Fujishiro, A, Saito, et al |
J Anesth |
Commentary/Editorial| Commentaire/Éditorial |
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Fuse-Nagase, Y, Kuroda, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Futter, A, Watson, et al |
Bulletin of the Atomic Scientists |
Commentary/Editorial| Commentaire/Éditorial |
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Gaidhane, S, Khatib, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Galili, U |
Vaccine |
Commentary/Editorial| Commentaire/Éditorial |
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Opposing the toxic apartheid: The painted veil of the COVID-19 pandemic, race and racism |
Gao, G, Sai, et al |
Gender, Work and Organization |
Commentary/Editorial| Commentaire/Éditorial |
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Gao, W, Deng, et al |
Aging (Albany NY) |
Commentary/Editorial| Commentaire/Éditorial |
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Gao, W, Li, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Garriboli, M, Mishra, et al |
Br J Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Letter: unknown denominator and misleading conclusions in Covid-19—authors' reply |
Garrido, I, Liberal, et al |
Alimentary Pharmacology and Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
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Gawda, R, Marszalski, et al |
Anaesthesiology intensive therapy |
Commentary/Editorial| Commentaire/Éditorial |
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Gebhart, F |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Gerotziafas, GT, Catalano, et al |
Thromb Haemost |
Commentary/Editorial| Commentaire/Éditorial |
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Gershman, J |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Ghate, VC, Borage, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Complement and coagulation: key triggers of COVID-19-induced multiorgan pathology |
Ghebrehiwet, B, Peerschke, et al |
J Clin Invest |
Commentary/Editorial| Commentaire/Éditorial |
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Ghosh, A, Sharma, et al |
Fam Pract |
Commentary/Editorial| Commentaire/Éditorial |
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Delays in the diagnosis of oral cancer due to the quarantine of COVID-19 in Córdoba, Argentina |
Gilligan, G, Lazos, et al |
Spec Care Dentist |
Commentary/Editorial| Commentaire/Éditorial |
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Goldani, LZ, Salort, et al |
Brazilian Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Green, ST, Cladi, et al |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Griffin, S |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Grossi, E, Terruzzi, et al |
Journal of Infection |
Commentary/Editorial| Commentaire/Éditorial |
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Artificial intelligence in health care: La Machine, le Médecin et Moi or the world of S.A.R.R.A.? |
Gruson, D |
Information Psychiatrique |
Commentary/Editorial| Commentaire/Éditorial |
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Guaraldi, G, Meschiari, et al |
The Lancet Rheumatology |
Commentary/Editorial| Commentaire/Éditorial |
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Ending the COVID-19 Pandemic Requires More International Collaboration |
Guimón, J, Narula, et al |
Research Technology Management |
Commentary/Editorial| Commentaire/Éditorial |
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Guizzo, BS, Marcello, et al |
Educacao e Pesquisa |
Commentary/Editorial| Commentaire/Éditorial |
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Gündogan, R |
Pharmaceutisch weekblad |
Commentary/Editorial| Commentaire/Éditorial |
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Perioperative management strategies for surgical patients during the COVID-19 outbreak |
Guo, W, Yuan, et al |
Chinese Journal of Digestive Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Sars-cov-2 infection and lung cancer: Potential therapeutic modalities |
Gupta, I, Rizeq, et al |
Cancers |
Commentary/Editorial| Commentaire/Éditorial |
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Senior management in times of COVID-19: Interview with María Isabel Rojo Gutiérrez |
Gutiérrez, MIR, Sánchez, et al |
Revista alergia Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Gwenzi, W |
Science of the Total Environment |
Commentary/Editorial| Commentaire/Éditorial |
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Habtamu, E |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Red blood cell exchange for SARS-CoV-2: A Gemini of therapeutic opportunities |
Hacking, SM |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Halacli, B, Topeli, et al |
Journal of Critical and Intensive Care |
Commentary/Editorial| Commentaire/Éditorial |
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Hamid, H, Mallhi, et al |
Drugs and Therapy Perspectives |
Commentary/Editorial| Commentaire/Éditorial |
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32890192; Development of the Emergency Services Swab Resource Team During COVID-19 |
Hamm, R, Komansky, et al |
Journal for nurses in professional development |
Commentary/Editorial| Commentaire/Éditorial |
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Han, J, Zhang, et al |
Ecotoxicology and environmental safety |
Commentary/Editorial| Commentaire/Éditorial |
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Anemia is associated with severe coronavirus disease 2019 (COVID-19) infection |
Hariyanto, TI, Kurniawan, et al |
Transfusion and Apheresis Science |
Commentary/Editorial| Commentaire/Éditorial |
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Are open-source approaches the most efficient way forward for COVID-19 drug discovery? |
Harky, A, Mishra, et al |
Expert Opin Drug Discov |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 and the racial equity implications of reopening college and university campuses |
Harper, SR |
American Journal of Education |
Commentary/Editorial| Commentaire/Éditorial |
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Harraq, J, Hattaf, et al |
Communications in Mathematical Biology and Neuroscience |
Commentary/Editorial| Commentaire/Éditorial |
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Special Section: Religion and Health Response to the COVID-19 Pandemic |
Hart, CW, Koenig, et al |
J Relig Health |
Commentary/Editorial| Commentaire/Éditorial |
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Out-of-hospital deaths among children during COVID-19 pandemic: Indicator of collateral damage? |
Harve-Rytsälä, H, Puhakka, et al |
BMJ Paediatrics Open |
Commentary/Editorial| Commentaire/Éditorial |
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32790642; Digital Response During the COVID-19 Pandemic in Saudi Arabia |
Hassounah, M, Raheel, et al |
Journal of medical Internet research |
Commentary/Editorial| Commentaire/Éditorial |
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Hawkins, ES, Fertel, et al |
American Journal of Emergency Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Henderson, CE, Rezai, et al |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
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Hennessy, M |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Hennessy, M |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Hennessy, O, Fowler, et al |
Br J Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Administering a stay-at-home dental groos anatomy practical during COVID-19 |
Herr, MJ, Nelson, et al |
J Dent Educ |
Commentary/Editorial| Commentaire/Éditorial |
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Unequal discourses: Problems of the current model of world health development |
Ho, JM, Li, et al |
World Development |
Commentary/Editorial| Commentaire/Éditorial |
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Hoernke, K |
J R Soc Med |
Commentary/Editorial| Commentaire/Éditorial |
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Hoffman, JJ, Hoffman, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Short-term surgical missions to resource-limited settings in the wake of the COVID-19 pandemic |
Honeyman, C, Patel, et al |
Journal of Plastic, Reconstructive and Aesthetic Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Routine Vaccination Disruption in Low-Income Countries: An Impact of COVID-19 Pandemic |
Hossain, MM, Abdulla, et al |
Asia Pac J Public Health |
Commentary/Editorial| Commentaire/Éditorial |
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32890187; Residency Classes Going Virtual: The COVID-19 Crisis |
Houle, J, Fleming, et al |
Journal for nurses in professional development |
Commentary/Editorial| Commentaire/Éditorial |
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Hu, V, Kyari, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Hu, V, Wolvaardt, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Hu, Z, Li, et al |
Cytokine and Growth Factor Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Mechanisms and control measures of COVID-19 related liver injuries |
Huang, A, Yang, et al |
Chinese Journal of Digestive Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Huang, CF, Sun, et al |
Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Editorial: intended victim or innocent bystander? The liver in COVID-19—Authors' reply |
Huang, H, Chen, et al |
Alimentary Pharmacology and Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
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Sepsis-associated severe interleukin-6 storm in critical coronavirus disease 2019 |
Huang, L, Zhao, et al |
Cell Mol Immunol |
Commentary/Editorial| Commentaire/Éditorial |
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Huddy, JR, Rasheed, et al |
J Gastrointest Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Humboldt-Dachroeden, S, Rubin, et al |
One Health |
Commentary/Editorial| Commentaire/Éditorial |
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Huo, J, Zhao, et al |
Cell Host and Microbe |
Commentary/Editorial| Commentaire/Éditorial |
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32890206; Evaluating Covid-19 Injury Claims With a Focus on Workers' Compensation |
Hyman, MH, Talmage, et al |
Journal of occupational and environmental medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19 what community pharmacies are doing
in the hardest-hit states |
Ientile, G |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Ientile, G |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Oxford’s covid-19 vaccine induces
strong immune responses in early-stage trial |
Ientile, G |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Ientile, G |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Ing, EB, Xu, et al |
Occup Med (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
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Irfan, IS, Awang, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Iwasaka, S, Shono, et al |
Journal of Infection and Chemotherapy |
Commentary/Editorial| Commentaire/Éditorial |
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Jachak, S, Phansopkar, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Novel coronavirus(Covid19), Its renal manifestations, and complications |
Jadali, Z |
Urol J |
Commentary/Editorial| Commentaire/Éditorial |
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Jansa, P, Aschermann, et al |
Cor et vasa |
Commentary/Editorial| Commentaire/Éditorial |
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Jiang, Y, Li, et al |
Brachytherapy |
Commentary/Editorial| Commentaire/Éditorial |
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Jin, C, Kim, et al |
Am J Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
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Jone, DA |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Role of vitamin d in prevention of corona virus infection (Covid-19) |
Juneja, S, Dangore-Khasbage, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Jungmayr, P |
Deutsche Apotheker Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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Kaess, M, Moessner, et al |
J Child Psychol Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Kamineni, SRT, Balu, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Over the hump: Have we reached the peak of carbon emissions? |
Kammen, DM |
Bulletin of the Atomic Scientists |
Commentary/Editorial| Commentaire/Éditorial |
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Kampf, G |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Kanamori, H |
Journal of Infection |
Commentary/Editorial| Commentaire/Éditorial |
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Changing ophthalmic practice during
the COVID-19 pandemic in Uganda |
Kanji, RR, Arunga, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Kapl, MN, Mahakalkar, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Kaplan, SA |
J Urol |
Commentary/Editorial| Commentaire/Éditorial |
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Mental health of mental health professionals during COVID-19 pandemic: Who cares for it? |
Kar, SK, Singh, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Kara, M, Ekiz, et al |
Br J Nutr |
Commentary/Editorial| Commentaire/Éditorial |
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Karetová, D, Bultas, et al |
Cor et vasa |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7395589; COVID-19's impacts on migrant workers from Bangladesh: In search of policy intervention |
Karim, MR, Islam, et al |
World Dev |
Commentary/Editorial| Commentaire/Éditorial |
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My e-learning experience as a medical student during the COVID-19 pandemic |
Karki, P |
Journal of the Nepal Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Karst, M, Hollenhorst, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Kassir, M, Gupta, et al |
Dermatologic Therapy |
Commentary/Editorial| Commentaire/Éditorial |
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New challenges to surgery due to the COVID-19 pandemic: from tension to attention |
Kassir, R, Sauvat, et al |
Br J Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Kataki, S, Chatterjee, et al |
Resources, Conservation and Recycling |
Commentary/Editorial| Commentaire/Éditorial |
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ACEIs, ARBs, ibuprofen originally linked to COVID-19: the other side of the mirror |
Kelleni, MT |
Inflammopharmacology |
Commentary/Editorial| Commentaire/Éditorial |
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Kersten, BJ, Salden, et al |
Journal of clinical anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Khan, AA, Khan, et al |
Brief Bioinform |
Commentary/Editorial| Commentaire/Éditorial |
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Promising impacts of mesenchymal stem cell therapy in treatment of SARS-CoV-2 (COVID-19) |
Khorshidi, M, Zarezadeh, et al |
Heart and Lung |
Commentary/Editorial| Commentaire/Éditorial |
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Every Body Counts: Measuring Mortality From the COVID-19 Pandemic |
Kiang, MV, Irizarry, et al |
Ann Intern Med |
Commentary/Editorial| Commentaire/Éditorial |
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Kim, K |
Science Editing |
Commentary/Editorial| Commentaire/Éditorial |
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Kim, KT, You, et al |
Occup Med (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
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Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19? |
Kjellberg, A, De Maio, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Kkese, E |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Koetter, P, Pelton, et al |
American Journal of Infection Control |
Commentary/Editorial| Commentaire/Éditorial |
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Köhnlein, C |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Hypothesis: Nasal vs. oral inhalation accounts for the severity of COVID-19 |
Komisaruk, BR |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Kreckel, PA |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Hurricane Evacuation Laws in Eight Southern U.S. Coastal States - December 2018 |
Kruger, J, Smith, et al |
MMWR Morb Mortal Wkly Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Kuleshov, MV, Stein, et al |
Patterns (N Y) |
Commentary/Editorial| Commentaire/Éditorial |
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Kumar, A, Kumar, et al |
Trends in Anaesthesia and Critical Care |
Commentary/Editorial| Commentaire/Éditorial |
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Kusnadi, IH, Hikmawan, et al |
International Journal of Engineering Research and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Kyari, F, Watts, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Kyle-Sidell, C |
Annals of the American Thoracic Society |
Commentary/Editorial| Commentaire/Éditorial |
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Lal, MM |
J Nurs Adm |
Commentary/Editorial| Commentaire/Éditorial |
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Teleprehabilitation during COVID-19 pandemic: the essentials of "what" and "how" |
Lambert, G, Drummond, et al |
Support Care Cancer |
Commentary/Editorial| Commentaire/Éditorial |
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Larenas-Linnemann, D, Del Río-Navarro, et al |
Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) |
Commentary/Editorial| Commentaire/Éditorial |
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Larios-Navarro, A, Bohórquez-Rivero, et al |
Revista Colombiana de Psiquiatria |
Commentary/Editorial| Commentaire/Éditorial |
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Lawless, MT, Archibald, et al |
JMIR Res Protoc |
Commentary/Editorial| Commentaire/Éditorial |
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Layach, OB |
Systematic Reviews in Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
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Leitner, T, Kumar, et al |
Molecular biology and evolution |
Commentary/Editorial| Commentaire/Éditorial |
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Lemprière, S |
Nature Reviews Neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Leray, M, Vila, et al |
La Revue du praticien |
Commentary/Editorial| Commentaire/Éditorial |
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Levi, N, Ganchrow, et al |
Physical Therapy |
Commentary/Editorial| Commentaire/Éditorial |
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Levine, RL |
Sci Adv |
Commentary/Editorial| Commentaire/Éditorial |
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China's coronavirus vaccine shows military's growing role in medical research |
Lewis, D |
Nature |
Commentary/Editorial| Commentaire/Éditorial |
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Lewkonia, P |
World Neurosurgery |
Commentary/Editorial| Commentaire/Éditorial |
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Potential Immunotherapeutic Targets for Hypoxia Due to COVI-Flu |
Leyfman, Y, Erick, et al |
Shock |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7454704; Overcoming Challenges in Coronavirus Disease 19 Translational Research |
Li, JZ, Yu, et al |
J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Factors Associated with Nursing Homesʼ Late Participation in COVID-19 Reporting |
Li, Y, Fang, et al |
Journal of the American Geriatrics Society |
Commentary/Editorial| Commentaire/Éditorial |
|
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Li, Y, Liang, et al |
Financ Res Lett |
Commentary/Editorial| Commentaire/Éditorial |
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Teaching microwaves in the time of COVID-19 [Educator's Corner] |
Li, Z |
IEEE Microwave Magazine |
Commentary/Editorial| Commentaire/Éditorial |
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Partnerships as an Avenue to Translate Emerging Disease Ecology of SARS-CoV-2 to Agricultural
Groups |
Liebman, A, Roy, et al |
J Agromedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Lima, R, Gootkind, et al |
BMC Med Res Methodol |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Food and drink companies are exploiting pandemic to further their brands, analysis finds |
Limb, M |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Blockchain Technology in Current Agricultural Systems: From Techniques to Applications |
Lin, W, Huang, et al |
IEEE Access |
Commentary/Editorial| Commentaire/Éditorial |
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Linnemayr, S, Jennings Mayo-Wilson, et al |
AIDS Behav |
Commentary/Editorial| Commentaire/Éditorial |
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The Impact of COVID-19 on Obsessive-Compulsive Disorder Patients |
Littman, R, Naftalovich, et al |
Psychiatry Clin Neurosci |
Commentary/Editorial| Commentaire/Éditorial |
|
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Cleaning and disinfection
in health care settings during the COVID-19 outbreak |
Liu, XY, Zhang, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Liu, Y, Fu, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Literature analysis of the efficacy of arbidol in virus infectious diseases |
Liu, Y, Shen, et al |
Biointerface Research in Applied Chemistry |
Commentary/Editorial| Commentaire/Éditorial |
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López Reboiro, ML, Sardiña González, et al |
Acta Medica Portuguesa |
Commentary/Editorial| Commentaire/Éditorial |
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Lotfi, AS, Capatina, et al |
Am J Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
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Loyola, MA |
Physis |
Commentary/Editorial| Commentaire/Éditorial |
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Lu, J, Li, et al |
Chinese Journal of Digestive Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Outbreak Associated with Air Conditioning in Restaurant, Guangzhou, China, 2020 |
Lu, J, Yang, et al |
Emerg Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Urologists and the Novel Coronavirus Disease 2019 (COVID-19): a Urologist's Perspective from China |
Lu, Y, Liu, et al |
Urol J |
Commentary/Editorial| Commentaire/Éditorial |
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Lucchini, A, Iozzo, et al |
Intensive and Critical Care Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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Luks, AM, Swenson, et al |
Annals of the American Thoracic Society |
Commentary/Editorial| Commentaire/Éditorial |
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Lustig, LR |
Otol Neurotol |
Commentary/Editorial| Commentaire/Éditorial |
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Attention to psychiatry and pharmacotherapy
during the COVID-19 pandemic |
Luykx, JJ, Tijdink, et al |
Tijdschrift voor Psychiatrie |
Commentary/Editorial| Commentaire/Éditorial |
|
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Letter: liver involvement and mortality in COVID-19 patients |
Lv, XH, Yang, et al |
Alimentary Pharmacology and Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
|
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Lymperopoulos, IN |
Expert Systems with Applications |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 related regulatory change for pharmacists – The case for its retention post the pandemic |
Lynch, M, O'Leary, et al |
Research in Social and Administrative Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
|
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Ma, Q, Yang, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Words, numbers, warnings, tips, but still low risk perception |
Macchi, L |
Mind and Society |
Commentary/Editorial| Commentaire/Éditorial |
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MacEvilly, D, Brosnan, et al |
Ir J Psychol Med |
Commentary/Editorial| Commentaire/Éditorial |
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Why is mental health of the geriatric population at a higher risk during the COVID-19 pandemic? |
Mackolil, J, Mackolil, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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The great awakening-digitalization in dental healthcare during the pandemic covid19 |
Madhu, PP, Patil, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Maguire, G |
Future Science OA |
Commentary/Editorial| Commentaire/Éditorial |
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Maldonado, F, Rafael, et al |
Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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YOGIC INTERVENTIONS for PSYCHO-PHYSICAL WELL-BEING under COVID-19 TIMES & after |
Malik, N, Sharma, et al |
Asia Pacific Journal of Health Management |
Commentary/Editorial| Commentaire/Éditorial |
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Mallet, C, Lafarge, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Where does work belong anymore? The implications of intensive homebased working |
Mallett, O, Marks, et al |
Gender in Management |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and anti-globalization issues: A cultural perspective |
Manshur, FM, Husni, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Mansour, A, Mohajeri-Tehrani, et al |
EXCLI Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Marian, AJ |
Cardiovascular Pathology |
Commentary/Editorial| Commentaire/Éditorial |
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Eye care during the COVID-19 public
health emergency: A WHO perspective |
Mariotti, S, Keel, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Mastroianni, G, Cano Busnelli, et al |
Ann Med Surg (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
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Mateiro Gomes, BL, Carvalho, et al |
Pulmonology |
Commentary/Editorial| Commentaire/Éditorial |
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32634026; COVID-19 Clinical Trials: Unraveling a Methodological Gordian Knot |
Mathioudakis, AG, Fally, et al |
American journal of respiratory and critical care medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Matsubara, S, Matsubara, et al |
J Obstet Gynaecol Res |
Commentary/Editorial| Commentaire/Éditorial |
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A conversation with a physician in italy regarding the covid-19 pandemic |
Mazzola, P |
University of Toronto Medical Journal |
Commentary/Editorial| Commentaire/Éditorial |
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McCartney, PR |
JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing |
Commentary/Editorial| Commentaire/Éditorial |
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McFee, DRB |
Disease-a-Month |
Commentary/Editorial| Commentaire/Éditorial |
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Safeguarding children's right to health in hospital during COVID-19 |
McIntosh, Jennifer, Aresté, et al |
The Lancet Child & Adolescent Health |
Commentary/Editorial| Commentaire/Éditorial |
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Medvedev, DA |
Russia in Global Affairs |
Commentary/Editorial| Commentaire/Éditorial |
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Adapting medical education during crisis: Student-Faculty partnerships as an enabler of success |
Mehta, N, End, et al |
Med Teach |
Commentary/Editorial| Commentaire/Éditorial |
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Meini, S, Giani, et al |
Mol Biol Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Telerehabilitation for people with breast cancer through the COVID-19 pandemic in Chile |
Mella-Abarca, W, Barraza-Sánchez, et al |
ecancermedicalscience |
Commentary/Editorial| Commentaire/Éditorial |
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Menon, V, Padhy, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Meyer, C, Becot, et al |
J Agromedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Infectiology:
Lung cancer patients with COVID-19 are (too) rarely treated in the intensive care unit |
Meyer, R |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Michelozzi, P, de'Donato, et al |
BMC public health |
Commentary/Editorial| Commentaire/Éditorial |
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Worldwide Effects of Coronavirus Disease Pandemic on Tuberculosis Services, January-April 2020 |
Migliori, GB, Thong, et al |
Emerg Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Milani, GP, Bottino, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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The importance of planning in the face of the
COVID-19 pandemic in Paraguay |
Miltos, CP, Duerksen, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Misra, Vikram |
The Lancet Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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It is unprecedented: trial management during the COVID-19 pandemic and beyond |
Mitchell, EJ, Ahmed, et al |
Trials |
Commentary/Editorial| Commentaire/Éditorial |
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Monti, S, Montecucco, et al |
Annals of the Rheumatic Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Myocardial and microvascular injury due to Coronavirus disease 2019 |
Montone, RA, Iannaccone, et al |
European Cardiology Review |
Commentary/Editorial| Commentaire/Éditorial |
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Mörchen, M, Kapoor, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Müller, SM, Mueller, et al |
Biology |
Commentary/Editorial| Commentaire/Éditorial |
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Müller, U |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Murrell, DF, Lucky, et al |
J Am Acad Dermatol |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: PERSPECTIVES from the EXPERIENCE of ONE AUSTRALIAN PRIMARY HEALTH NETWORK |
Nankervis, R, Alexander, et al |
Asia Pacific Journal of Health Management |
Commentary/Editorial| Commentaire/Éditorial |
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Nanotkar, L, Dhanvij, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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A Wench’s Guide to Surviving a ‘Global’ Pandemic Crisis: Feminist Publishing in a Time of COVID-19 |
Naqvi, ZB, Russell, et al |
Feminist Legal Studies |
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32884675; The most recent advances in understanding and managing hidradenitis suppurativa |
Narla, S, Lyons, et al |
F1000Research |
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The role of Interleukin 6 inhibitors in therapy of severe COVID-19 |
Nasonov, E, Samsonov, et al |
Biomedicine and Pharmacotherapy |
Commentary/Editorial| Commentaire/Éditorial |
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Negro, F, Moradpour, et al |
Revue medicale suisse |
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Nelson, CP, Sama, et al |
Circulation |
Commentary/Editorial| Commentaire/Éditorial |
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Neri-Vela, R, Carrillo-Esper, et al |
Revista Mexicana de Anestesiologia |
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Nessaibia, I, Siciliano, et al |
Int J Health Plann Manage |
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Nibudey, A, Vidya Baliga, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Defensin 5 for prevention of SARS-CoV-2 invasion and Covid-19 disease |
Niv, Y |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Taking long term care from crisis to thriving in the time of COVID-19 |
Norwood, F, Lynn, et al |
Journal of Aging Studies |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and Kidney Disease Disparities in the United States |
Novick, TK, Rizzolo, et al |
Advances in Chronic Kidney Disease |
Commentary/Editorial| Commentaire/Éditorial |
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O'Brien, TR, Thomas, et al |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Oh, S |
Science Editing |
Commentary/Editorial| Commentaire/Éditorial |
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An online repository of solvation thermodynamic and structural maps of SARS-CoV-2
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Olson, B, Cruz, et al |
J Comput Aided Mol Des |
Commentary/Editorial| Commentaire/Éditorial |
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Time to include pandemic preparedness training to healthcare curriculum |
Omar, UF, Kharlukhi, et al |
Med Educ Online |
Commentary/Editorial| Commentaire/Éditorial |
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Omboni, S, McManus, et al |
Hypertension |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19: Adaptations and changes
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Onakoya, A |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Ooi, R, Ooi, et al |
Med Educ Online |
Commentary/Editorial| Commentaire/Éditorial |
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Opel, DJ, Diekema, et al |
JAMA Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Orellana, J, Del Giorgio, et al |
Revista de la Federacion Argentina de Cardiologia |
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Orsi, MA, Oliva, et al |
Journal of Breast Imaging |
Commentary/Editorial| Commentaire/Éditorial |
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Osawa, A, Maeshima, et al |
Geriatrics and Gerontology International |
Commentary/Editorial| Commentaire/Éditorial |
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Ostuzzi, G, Papola, et al |
BMC Med |
Commentary/Editorial| Commentaire/Éditorial |
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Leadership After a Crisis: The Application of Psychological First Aid |
Owen, RD, Schimmels, et al |
J Nurs Adm |
Commentary/Editorial| Commentaire/Éditorial |
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Özman, O |
Urol J |
Commentary/Editorial| Commentaire/Éditorial |
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Angiotensin Converting Enzyme-2 (ACE2) receptors, asthma and severe COVID-19 infection risk |
Öztürk, AB, Çağlayan, et al |
Eur Ann Allergy Clin Immunol |
Commentary/Editorial| Commentaire/Éditorial |
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Editorial: intended victim or innocent bystander? The liver in COVID-19 |
Packer, G, Bangash, et al |
Alimentary Pharmacology and Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
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Serological assays for delayed SARS-CoV-2 case identification – Author's reply |
Pallett, ScottJC, Rayment, et al |
The Lancet Respiratory Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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PI3Kδ Inhibition as a Potential Therapeutic Target in COVID-19 |
Palma, G, Pasqua, et al |
Frontiers in Immunology |
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Ready, Set, BABY Live Virtual Prenatal Breastfeeding Education for COVID-19 |
Palmquist, AEL, Parry, et al |
J Hum Lact |
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Panda, SR |
Taiwanese Journal of Obstetrics and Gynecology |
Commentary/Editorial| Commentaire/Éditorial |
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Pandey, J, Chakraborty, et al |
Asia Pacific Journal of Health Management |
Commentary/Editorial| Commentaire/Éditorial |
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The impact of the Covid-19 health crisis on the water cycle in France |
Paplorey, C |
Houille Blanche |
Commentary/Editorial| Commentaire/Éditorial |
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Paredes-Angeles, R, Taype-Rondan, et al |
Revista Colombiana de Psiquiatria |
Commentary/Editorial| Commentaire/Éditorial |
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Parikh, P, Diep, et al |
Cities |
Commentary/Editorial| Commentaire/Éditorial |
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Preserving 2 decades of healthcare gains for Africa in the coronavirus disease 2019 era |
Pastakia, SD, Braitstein, et al |
Aids |
Commentary/Editorial| Commentaire/Éditorial |
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Pharmaceutical education
and research: Post the COVID-19 pandemic |
Patani, G |
Indian Drugs |
Commentary/Editorial| Commentaire/Éditorial |
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Patel, S, Gannon, et al |
Ir J Psychol Med |
Commentary/Editorial| Commentaire/Éditorial |
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Patel, U, Malik, et al |
Journal of neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Pavia, CS, Wormser, et al |
Diagnostic microbiology and infectious disease |
Commentary/Editorial| Commentaire/Éditorial |
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Pavlinec, J, Su, et al |
J Urol |
Commentary/Editorial| Commentaire/Éditorial |
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Pawinru, AS |
Systematic Reviews in Pharmacy |
Commentary/Editorial| Commentaire/Éditorial |
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Pena, E, Ahmed, et al |
Addiction |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of the COVID-19 pandemic on a population-based breast cancer screening program |
Peng, SM, Yang, et al |
Cancer |
Commentary/Editorial| Commentaire/Éditorial |
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Perez, DL, Biffi, et al |
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology |
Commentary/Editorial| Commentaire/Éditorial |
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Environmental health leadership on climate solutions
amidst covid-19 |
Perkowitz, RM, Speiser, et al |
Journal of environmental health |
Commentary/Editorial| Commentaire/Éditorial |
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Peters, R |
Pharmaceutical Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Peters, R |
Pharmaceutical Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Petitjeans, F, Martinez, et al |
Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Ecologic association between influenza and COVID-19 mortality rates in European countries |
Petti, S, Cowling, et al |
Epidemiol Infect |
Commentary/Editorial| Commentaire/Éditorial |
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Pham, NC, Li, et al |
Asia Pacific Journal of Health Management |
Commentary/Editorial| Commentaire/Éditorial |
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Mental and behavioral changes during COVID 19 pandemic and how to deal with it |
Philip, M, Mahakalka, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 numbers and models: Misleading
us, or leading us out of misery? |
Philippin, H, Knoll, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Phillips, L, Pavisic, et al |
Blood Adv |
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Piagnerelli, M, Cauchie, et al |
Crit Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7330528; Sport Integrity Opportunities in the Time of Coronavirus |
Pitsiladis, Y, Muniz-Pardos, et al |
Sports Med |
Commentary/Editorial| Commentaire/Éditorial |
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Drug information association (DIA) 2020 virtual global annual meeting (june 14-18, 2020) |
Polychrones, J |
Drugs of Today |
Commentary/Editorial| Commentaire/Éditorial |
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Letter: liver involvement and mortality in COVID-19 patients – authors' reply |
Ponziani, FR, Del Zompo, et al |
Alimentary Pharmacology and Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
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Ophthalmic practice protocols
during the COVID-19 pandemic - the Aravind way |
Prajna, NV |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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32890228; Balancing Health and Economic Factors When Reopening Business in the Age of COVID-19 |
Pronk, NP, Kassler, et al |
Journal of occupational and environmental medicine |
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Quinn, KG, Walsh, et al |
AIDS Behav |
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Viewpoint: Jordan’s public and surveillance health policies: During and after COVID-19 |
Qutob, RA, Ajlouni, et al |
Jordan Journal of Pharmaceutical Sciences |
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COVID-19 Viral and Serology Testing in New York City Health Care Workers |
Racine-Brzostek, S, Yang, et al |
Am J Clin Pathol |
Commentary/Editorial| Commentaire/Éditorial |
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Perioperative Pain Management During the COVID-19 Pandemic: A Telemedicine Approach |
Rahman, S, Speed, et al |
Pain Med |
Commentary/Editorial| Commentaire/Éditorial |
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Rajpal, S, Tong, et al |
JAMA Cardiol |
Commentary/Editorial| Commentaire/Éditorial |
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Rallis, K, Barton, et al |
Med Teach |
Commentary/Editorial| Commentaire/Éditorial |
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Ramakrishnan, VS, Kim, et al |
Australas Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Ramos, AK, Duysen, et al |
J Agromedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Yoga for COVID-19 and natural disaster related mental health issues: Challenges and perspectives |
Ransing, R, Pinto da Costa, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Ray, I |
World Dev |
Commentary/Editorial| Commentaire/Éditorial |
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Plastic surgery training during COVID-19: Challenges and novel learning opportunities |
Reed, AJM, Chan, et al |
Journal of Plastic, Reconstructive and Aesthetic Surgery |
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Organizational measures aiming to combat COVID-19 in the Russian Federation: the first experience |
Reshetnikov, V, Mitrokhin, et al |
Expert Rev Pharmacoecon Outcomes Res |
Commentary/Editorial| Commentaire/Éditorial |
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Rhodes, Anthea, Hoq, et al |
The Lancet Infectious Diseases |
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Covid-19: "protecting the NHS" encourages people with symptoms to stay at home |
Ridsdale, L |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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IEEE 802.11ah Network Challenges Supports Covid-19 Prevention Team |
Riza, TA, Gunawan, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Rizzo, E, Carlà, et al |
EClinicalMedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Rodrigues, IA, Cavalcante, et al |
Physis |
Commentary/Editorial| Commentaire/Éditorial |
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Digital didactic materials and coronavirus during confinement in the Spanish context |
Rodríguez, JR, Gómez, et al |
Praxis Educativa |
Commentary/Editorial| Commentaire/Éditorial |
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Rodríguez, MS |
Arch Argent Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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Rodriguez, Z, Shane, et al |
Blood Adv |
Commentary/Editorial| Commentaire/Éditorial |
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Letter: unknown denominator and misleading conclusions in COVID-19 |
Rodríguez-Perálvarez, M, Salcedo, et al |
Alimentary Pharmacology and Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
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Romanillos, PMO |
Revista alergia Mexico |
Commentary/Editorial| Commentaire/Éditorial |
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Romanzi, A, Vannelli, et al |
Tumori |
Commentary/Editorial| Commentaire/Éditorial |
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Rosen, GH, Golzy, et al |
J Urol |
Commentary/Editorial| Commentaire/Éditorial |
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International experiences of the active period of COVID-19 - Mental health care |
Rosenberg, S, Mendoza, et al |
Health Policy and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Rossi, M, Piagnerelli, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Roy-Gash, F, De Mesmay, et al |
Critical Care (London, England) |
Commentary/Editorial| Commentaire/Éditorial |
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Ruiz, Estrada, Mario Arturo |
SSRN- Lancet prepublication |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Outbreak Associated with Air Conditioning in Restaurant, Guangzhou, China, 2020 |
Rule, AM |
Emerg Infect Dis |
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Russi, L |
Anthropological Quarterly |
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Ruzicka, JA |
Thrombosis research |
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Sacco, A |
Medicina del Lavoro |
Commentary/Editorial| Commentaire/Éditorial |
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Repurposing Drugs, Ongoing Vaccine, and New Therapeutic Development Initiatives Against COVID-19 |
Saha, RP, Sharma, et al |
Frontiers in Pharmacology |
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Şahin, M |
Intern Emerg Med |
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Is the transmission of novel coronavirus disease (COVID-19) weather dependent? |
Sahoo, PK |
J Air Waste Manag Assoc |
Commentary/Editorial| Commentaire/Éditorial |
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Floating countries and corona pandemic: Impact of covid-19 on stranded cruise ships |
Sahu, A, Naqvi, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of coronavirus disease (COVID-19) pandemic on multiple sclerosis care |
Salama, S, Ahmed, et al |
Clinical neurology and neurosurgery |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 Impact on Childcare in Agricultural Populations |
Salzwedel, M, Liebman, et al |
J Agromedicine |
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Sánchez, DAH |
Revista alergia Mexico |
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Sanhueza-Alvarado, O |
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Commentary/Editorial| Commentaire/Éditorial |
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A role of glycation and methylation for SARS-CoV-2 infection in diabetes? |
Sartore, G, Ragazzi, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Satomi, K, Watanabe, et al |
Journal of Arrhythmia |
Commentary/Editorial| Commentaire/Éditorial |
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Lessons Learned: Pediatric Telemental Health in a Rural Medical Center in the Age of SARS-CoV-2 |
Satti, K, Ojugbele, et al |
Journal of Rural Health |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 Aufklärung statt Panik Umfrage zum Coronavirus
zeigt Verunsicherung in der Bevölkerung |
Scherf-Clavel, O, Dinkel, et al |
Deutsche Apotheker Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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A flurry of covid-19 studies are
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Schieszer, J |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Schulze-Koops, H, Specker, et al |
Annals of the Rheumatic Diseases |
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Sehirli, AO, Sayiner, et al |
Mol Biol Rep |
Commentary/Editorial| Commentaire/Éditorial |
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Semenov, AV, Pshenichnaya, et al |
Russian Journal of Infection and Immunity |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 in Cushing disease: experience of a single tertiary centre in Lombardy |
Serban, AL, Ferrante, et al |
J Endocrinol Invest |
Commentary/Editorial| Commentaire/Éditorial |
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Design mobile application for health consultation during pandemic COVID 19 |
Setiawan, R, Kisman, et al |
International Journal of Advanced Trends in Computer Science and Engineering |
Commentary/Editorial| Commentaire/Éditorial |
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Seznec, JF |
Bulletin of the Atomic Scientists |
Commentary/Editorial| Commentaire/Éditorial |
|
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Can roflumilast become steroid-sparing alternative in the treatment of COVID-19? |
Shah, CA |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
|
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Sharma, M, Aggarwal, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
|
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Sharun, K, Tiwari, et al |
Hum Vaccin Immunother |
Commentary/Editorial| Commentaire/Éditorial |
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In Search for a Cure: Recommendation with Knowledge Graph on CORD-19 |
Shen, I, Zhang, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Shen, KL, Namazova-Baranova, et al |
World J Pediatr |
Commentary/Editorial| Commentaire/Éditorial |
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32890322; Guidelines for Ultrasound in the Radiology Department During the COVID-19 Pandemic |
Sheth, S, Fetzer, et al |
Ultrasound quarterly |
Commentary/Editorial| Commentaire/Éditorial |
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Shetty, G, Nougarahiya, et al |
International Journal of Current Research and Review |
Commentary/Editorial| Commentaire/Éditorial |
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Shin, H, Kang, et al |
Int J Hosp Manag |
Commentary/Editorial| Commentaire/Éditorial |
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Shoib, S, Yasir Arafat, et al |
Public health |
Commentary/Editorial| Commentaire/Éditorial |
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Shrestha, LB, Pokharel, et al |
Journal of the Nepal Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Shurson, GC |
Sustainability (Switzerland) |
Commentary/Editorial| Commentaire/Éditorial |
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Sia, CH, Ngiam, et al |
Singapore medical journal |
Commentary/Editorial| Commentaire/Éditorial |
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Impact of the COVID-19 pandemic on domestic violence in Bangladesh |
Sifat, RI |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Singh, A |
Korean J Anesthesiol |
Commentary/Editorial| Commentaire/Éditorial |
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The impact of COVID-19 on medical electives in plastic surgery – A medical students’ perspective |
Singh, U |
Journal of Plastic, Reconstructive and Aesthetic Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Singla, R, Mishra, et al |
Vet Res Commun |
Commentary/Editorial| Commentaire/Éditorial |
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Snelson, H |
Journal of Swine Health and Production |
Commentary/Editorial| Commentaire/Éditorial |
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Soldani, D |
Journal of Telecommunications and the Digital Economy |
Commentary/Editorial| Commentaire/Éditorial |
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32893532; Gastrointestinal involvement of COVID-19 and potential faecal transmission of SARS-CoV-2 |
Song, M, Li, et al |
Journal of Zhejiang University.Science.B |
Commentary/Editorial| Commentaire/Éditorial |
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Fight COVID-19 depression with immunity booster: Curcumin for psychoneuroimmunomodulation |
Soni, VK, Mehta, et al |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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The underfunding of the Unified Health System and its impact on coping with COVID-19 |
Souza, DO |
Physis |
Commentary/Editorial| Commentaire/Éditorial |
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Pathophysiological aspects of covid-19 and use of non-invasive ventilation. Is it possible? |
Spadari, JAA, Gardenghi, et al |
Revista Pesquisa em Fisioterapia |
Commentary/Editorial| Commentaire/Éditorial |
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Speeckaert, MM, De Buyzere, et al |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
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Sriwijitalai, W, Wiwanitkit, et al |
American Journal of Obstetrics and Gynecology |
Commentary/Editorial| Commentaire/Éditorial |
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Stahl, K, Bräsen, et al |
Intensive Care Med |
Commentary/Editorial| Commentaire/Éditorial |
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Stahl, V |
Deutsche Apotheker Zeitung |
Commentary/Editorial| Commentaire/Éditorial |
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Stephens, DS, McElrath, et al |
Jama |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7477601; The 'Industrial Enlightenment' and technological paradigms of the modern steel industry |
Suenaga, K |
Technol Soc |
Commentary/Editorial| Commentaire/Éditorial |
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Preanesthetic Povidone-Iodine gargles for patients with COVID-19 |
Suresh, V, Sharma, et al |
Journal of clinical anesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Recommendations for the so-called
off-label use of medicinal products in covid-19 patients |
Šustek, P, Holčapek, et al |
Anesteziologie a Intenzivni Medicina |
Commentary/Editorial| Commentaire/Éditorial |
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Swadling, L, Maini, et al |
Nature immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Swai, J |
Crit Care |
Commentary/Editorial| Commentaire/Éditorial |
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Swaminathan, A, Subramanian, et al |
GeroScience |
Commentary/Editorial| Commentaire/Éditorial |
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Tagliabue, M, Pietrobon, et al |
Eur Arch Otorhinolaryngol |
Commentary/Editorial| Commentaire/Éditorial |
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32882708; How does COVID-19 kill at home and what should we do about it? |
Tan, HL |
European heart journal |
Commentary/Editorial| Commentaire/Éditorial |
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Role of Eosinophils in the Diagnosis and Prognostic Evaluation of COVID-19 |
Tan, Y, Zhou, et al |
J Med Virol |
Commentary/Editorial| Commentaire/Éditorial |
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Are Proton Pump Inhibitors Contributing to SARS-COV-2 Infection? |
Tarlow, B, Gubatan, et al |
Am J Gastroenterol |
Commentary/Editorial| Commentaire/Éditorial |
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Tavormina, G, Tavormina, et al |
Psychiatria Danubina |
Commentary/Editorial| Commentaire/Éditorial |
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Taxonera, C, Alba, et al |
Alimentary Pharmacology and Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
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32890217; Safely Returning America to Work: Part I: General Guidance for Employers |
Taylor, T, Das, et al |
Journal of occupational and environmental medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Thangaraju, P, Arulmani, et al |
Asian Pacific Journal of Tropical Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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The Lancet, Gastroenterology, amp, et al |
The Lancet Gastroenterology & Hepatology |
Commentary/Editorial| Commentaire/Éditorial |
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Coronaviruses – Potential human threat from foodborne transmission? |
Thippareddi, H, Balamurugan, et al |
LWT |
Commentary/Editorial| Commentaire/Éditorial |
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Thomas, JV, Porter, et al |
Applied Radiology |
Commentary/Editorial| Commentaire/Éditorial |
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Tian, Y, Rong, et al |
Alimentary Pharmacology and Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
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Tian, Z, Kim, et al |
International Journal of Engineering Research and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Spreading of SARS-CoV-2 in West Africa and assessment of risk factors |
Tinto, B, Salinas, et al |
Epidemiol Infect |
Commentary/Editorial| Commentaire/Éditorial |
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Tisdall, L, Zhang, et al |
J Air Transp Manag |
Commentary/Editorial| Commentaire/Éditorial |
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Torlinski, T |
Anaesthesiology intensive therapy |
Commentary/Editorial| Commentaire/Éditorial |
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Simultaneous hospital/primary care real time simulation during COVID-19 alert |
Trastoy Quintela, J, Moure González, et al |
Anales de Pediatria |
Commentary/Editorial| Commentaire/Éditorial |
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32895816; Wie COVID-19 auf den Bauch schlägt: Gastrointestinale Manifestationen |
Treiber, M, Thimme, et al |
MMW-Fortschritte der Medizin |
Commentary/Editorial| Commentaire/Éditorial |
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Treviranus, GRS |
Psychiatria Danubina |
Commentary/Editorial| Commentaire/Éditorial |
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Tripathi, SK |
Journal of the Indian Medical Association |
Commentary/Editorial| Commentaire/Éditorial |
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Tutor Marcom, R, Freeman Lambar, et al |
J Agromedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Tvito, A, Ben-Chetrit, et al |
Int J Lab Hematol |
Commentary/Editorial| Commentaire/Éditorial |
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Unchwaniwala, N, Ahlquist, et al |
Science |
Commentary/Editorial| Commentaire/Éditorial |
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Underner, M, Perriot, et al |
Revue des maladies respiratoires |
Commentary/Editorial| Commentaire/Éditorial |
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Generational Differences and COVID-19: Positive Interactions in Virtual Workplaces |
Urick, M |
Journal of Intergenerational Relationships |
Commentary/Editorial| Commentaire/Éditorial |
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The COVID-19 pandemic in Norway: The dominance of social implications in framing the policy response |
Ursin, G, Skjesol, et al |
Health Policy and Technology |
Commentary/Editorial| Commentaire/Éditorial |
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Usherwood, T, Zhang, et al |
Mol Diagn Ther |
Commentary/Editorial| Commentaire/Éditorial |
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Uvais, NA, Rasmina, et al |
Occup Med (Lond) |
Commentary/Editorial| Commentaire/Éditorial |
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32548769; Doctor–patient relationship at the time of COVID-19: travel notes |
Vallelonga, F, Elia, et al |
Intensive care medicine |
Commentary/Editorial| Commentaire/Éditorial |
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van de Kraats, G, van Veen, et al |
Tijdschrift voor Psychiatrie |
Commentary/Editorial| Commentaire/Éditorial |
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The value of anaesthesiologists in the COVID-19 pandemic: a model for our future practice? |
van Klei, WA, Hollmann, et al |
British journal of anaesthesia |
Commentary/Editorial| Commentaire/Éditorial |
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Vannucci, J, Ruberto, et al |
Journal of Global Antimicrobial Resistance |
Commentary/Editorial| Commentaire/Éditorial |
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Varisco, TJ, Johnson, et al |
International Journal of Infectious Diseases |
Commentary/Editorial| Commentaire/Éditorial |
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Vasta, R, Moglia, et al |
Amyotroph Lateral Scler Frontotemporal Degener |
Commentary/Editorial| Commentaire/Éditorial |
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Velásquez, CL, Pirela, et al |
Avances en Quimica |
Commentary/Editorial| Commentaire/Éditorial |
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Veraldi, S, Angileri, et al |
Journal of Cosmetic Dermatology |
Commentary/Editorial| Commentaire/Éditorial |
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Clinical pearls for COVID-19 in children: what do pediatricians need to know? |
Verma, R, Amin, et al |
Pediatr Res |
Commentary/Editorial| Commentaire/Éditorial |
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Caremongering and Assumptions of Need: The Spread of Compassionate Ageism During COVID-19 |
Vervaecke, D, Meisner, et al |
Gerontologist |
Commentary/Editorial| Commentaire/Éditorial |
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Treatment with ACE inhibitors and AT1-blockers during the COVID-19 pandemic |
Veselý, J |
Cor et vasa |
Commentary/Editorial| Commentaire/Éditorial |
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Viktoria Stein, K, Goodwin, et al |
International Journal of Integrated Care |
Commentary/Editorial| Commentaire/Éditorial |
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Vinson, V |
Science |
Commentary/Editorial| Commentaire/Éditorial |
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Wadman, M |
Science |
Commentary/Editorial| Commentaire/Éditorial |
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Wang, C, Qu, et al |
Kexue Tongbao/Chinese Science Bulletin |
Commentary/Editorial| Commentaire/Éditorial |
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Recent Advances on Graph Analytics and Its Applications in Healthcare |
Wang, F, Cui, et al |
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Commentary/Editorial| Commentaire/Éditorial |
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Wang, Y, Zhang, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Wanjari, TN, Sawarkar, et al |
International Journal of Research in Pharmaceutical Sciences |
Commentary/Editorial| Commentaire/Éditorial |
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Warren, CJ, Davis, et al |
J Urol |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19, cancer and psycho-oncology: Dealing with the challenges |
Watson, M, Fielding, et al |
Psycho-oncology |
Commentary/Editorial| Commentaire/Éditorial |
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Watts, E, Leck, et al |
Community Eye Health Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Weiner, JA, Swiatek, et al |
European Spine Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Wenzel, RP |
Clin Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Widimský, P |
Cor et vasa |
Commentary/Editorial| Commentaire/Éditorial |
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COVID-19 and the renin-angiotensin system (RAS): A spark that sets the forest alight? |
Wiese, OJ, Allwood, et al |
Medical hypotheses |
Commentary/Editorial| Commentaire/Éditorial |
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Janus Family Kinase (JAK) Inhibitors in HLH and Severe COVID-19 |
Wilcox, RA |
Am J Hematol |
Commentary/Editorial| Commentaire/Éditorial |
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Wiley, F |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Invasive and non-invasive ventilation in patients with COVID-19 |
Windisch, W, Weber-Carstens, et al |
Deutsches Arzteblatt International |
Commentary/Editorial| Commentaire/Éditorial |
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Wing Shin, RT, Stoller, et al |
Journal of Critical Reviews |
Commentary/Editorial| Commentaire/Éditorial |
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Winkler, ES, Bailey, et al |
Nature immunology |
Commentary/Editorial| Commentaire/Éditorial |
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Covid-19: Scotland launches contact tracing app with England and Wales to follow |
Wise, J |
Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Wnuk, A, Oleksy, et al |
PLoS One |
Commentary/Editorial| Commentaire/Éditorial |
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Wu, C, Ye, et al |
Hypertension |
Commentary/Editorial| Commentaire/Éditorial |
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Wypler, J, Hoffelmeyer, et al |
J Agromedicine |
Commentary/Editorial| Commentaire/Éditorial |
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Out-of-hospital management strategies for gastric cancer patients during the COVID-19
outbreak |
Xue, K, Li, et al |
Chinese Journal of Digestive Surgery |
Commentary/Editorial| Commentaire/Éditorial |
|
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Living with COVID-19: What do psychiatric hospitals need to consider in the coming months? |
Yahyavi, ST |
Iranian Journal of Psychiatry and Behavioral Sciences |
Commentary/Editorial| Commentaire/Éditorial |
|
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Yan, H, Ouyang, et al |
Medicine (Baltimore) |
Commentary/Editorial| Commentaire/Éditorial |
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Yan, Y, Liu, et al |
Journal of Infection |
Commentary/Editorial| Commentaire/Éditorial |
|
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Management of acute ischemic stroke under routine infection prevention practices for COVID-19 |
Yang, B, Wang, et al |
J Neurointerv Surg |
Commentary/Editorial| Commentaire/Éditorial |
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Perinatal management of severe acute respiratory syndrome coronavirus 2 infection |
Yang, X, Shi, et al |
Chinese Journal of Obstetrics and Gynecology and Pediatrics |
Commentary/Editorial| Commentaire/Éditorial |
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Overall management strategies for liver cancer patients during the COVID-19 outbreak |
Yang, X, Sun, et al |
Chinese Journal of Digestive Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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Yıldırım, M, Solmaz, et al |
Death Stud |
Commentary/Editorial| Commentaire/Éditorial |
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Letter: gastrointestinal symptoms pre-admission are associated with greater severity of COVID-19 |
Yu, J, Xu, et al |
Alimentary Pharmacology and Therapeutics |
Commentary/Editorial| Commentaire/Éditorial |
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Spotlight on COVID-19: from biology to therapy and prevention |
Zacchigna, S, Marcello, et al |
FEBS Journal |
Commentary/Editorial| Commentaire/Éditorial |
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Zahn, LM |
Science |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7272331; The coronavirus pandemic - A critical discussion of a tourism research agenda |
Zenker, S, Kock, et al |
Tour Manag |
Commentary/Editorial| Commentaire/Éditorial |
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Zermatten, MG, Pantet, et al |
Thrombosis research |
Commentary/Editorial| Commentaire/Éditorial |
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The Influence of the Ongoing COVID-19 Pandemic on Family Violence in China |
Zhang, H |
Journal of Family Violence |
Commentary/Editorial| Commentaire/Éditorial |
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Data mining can play a critical role in COVID-19 linked mental health studies |
Zhang, T |
Asian Journal of Psychiatry |
Commentary/Editorial| Commentaire/Éditorial |
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Chinese Journal of Digestive Surgery |
Commentary/Editorial| Commentaire/Éditorial |
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PMC7454680; Interferon-Induced Transmembrane Protein 3 Related to Coronavirus Disease 2019 |
Zhao, T |
J Infect Dis |
Commentary/Editorial| Commentaire/Éditorial |
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Zheng, M, Ma, et al |
Chinese Journal of Digestive Surgery |
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J Exp Med |
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Commentary/Editorial| Commentaire/Éditorial |
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Responses of pediatric palliative care to the COVID-19 pandemic in China |
Zhou, X, Cai, et al |
Pediatr Res |
Commentary/Editorial| Commentaire/Éditorial |
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32876412; Proposed practice guidelines for burn centres in the context of the SARS-CoV-2 pandemic |
Zieliński, M, Wróblewski, et al |
Anaesthesiology intensive therapy |
Commentary/Editorial| Commentaire/Éditorial |
|
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Zilka, J |
Drug Topics |
Commentary/Editorial| Commentaire/Éditorial |
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Am J Epidemiol |
Commentary/Editorial| Commentaire/Éditorial |
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Annals of Agricultural and Environmental Medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Un llamado a la responsabilidad en las publicaciones en
tiempos de la COVID-19 |
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Avances en Psicologia Latinoamericana |
Commentary/Editorial| Commentaire/Éditorial |
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Update to living systematic review on drug treatments for covid-19 |
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Bmj |
Commentary/Editorial| Commentaire/Éditorial |
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Bulletin of the World Health Organization |
Commentary/Editorial| Commentaire/Éditorial |
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Infectio |
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PMC7261454; Restricted family visiting in intensive care during COVID-19 |
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Intensive Crit Care Nurs |
Commentary/Editorial| Commentaire/Éditorial |
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32890225; How do we Find a "New Normal" for Industry and Business After COVID-19 Shut Downs? |
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Journal of occupational and environmental medicine |
Commentary/Editorial| Commentaire/Éditorial |
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Introduction to the Special Issue on the Public Economics of COVID-19 |
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Journal of Public Economics |
Commentary/Editorial| Commentaire/Éditorial |
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The Lancet |
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The Lancet |
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The Lancet Planetary Health |
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Tijdschrift voor Psychiatrie |
Commentary/Editorial| Commentaire/Éditorial |
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One impact of the COVID-19 pandemic
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U.S.Pharmacist |
Commentary/Editorial| Commentaire/Éditorial |
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Chronobiology international |
Commentary/Editorial| Commentaire/Éditorial |
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Appendix: Process and definitions.
A daily search for new publications is conducted in PubMed, Scopus,
BioRxiv and MedRxiv, SSRN,
Research Square,
arXiv for all publications related to COVID-19 disease or SARS-CoV-2 using the search terms (COVID-19 OR SARS-CoV-2
OR "novel CoV" OR "novel coronavirus" OR nCoV) adapted to each database. The capture is cross-referenced with publication announcements on the COVID-19 dashboards set up by a number of publishers and google. Publishers include
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ, Wiley,
Springer Nature, ChinaCDCweekly.
Additionally the database is cross-referenced with other literature scans e.g.
WHO publication list and activities by collaborators. Members of the Emerging Sciences group develop 1 -2 point summaries of each publication. Please email Lisa Waddell for additional information:
Lisa.Waddell@canada.ca.
References are compiled in a reworks database that has citations since the beginning of the outbreak. All references can be accessed at this
link and by the categories listed below. The daily scan has also been compiled in an excel sheet and copies can be provided upon request or
accessed
here.
Category Definitions:
Modelling/ prediction: Predictive modeling is a process that uses data mining and probability
to forecast outcomes. Each model is made up of a number of predictors, which are variables that are likely to influence future results.
Epidemiology:
the branch of medicine which deals with the incidence, distribution, and possible control of diseases and other factors relating to health. Includes Ro, attack rates, case number doubling time, case fatality
rate, serial interval, clinical attack rate, asymptomatic fraction, proportion of asymptomatic and infective*
Transmission: The passage of a pathogen causing communicable disease from an infected host
to an uninfected host via direct or indirect routes.
Clinical data
of cases: Includes clinical parameters such as incubation period, latent period, period of communicability, duration of illness, duration of hospitalization, host risk factors, as well as clinical profiles of patients; presenting symptoms, symptoms over
course of illness, sequelae, comorbidities.*
Surveillance: Public health surveillance is the continuous, systematic collection, analysis and
interpretation of health-related data. Surveillance data will likely be number of cases suspected/confirmed, number of deaths, number recovered. *
Coronavirology: All research relating to the virus; its characteristics, genetic make-up, phylogenetic
analyses
Diagnostics / Pathogen detection:
All studies on identification of the virus; culture, PCR, antibody/antigen tests etc.
Therapeutics:
Studies of substances that may be used to treat infected hosts including passive immunization products.
Vaccine Research:
Studies of vaccine candidates to prevent infection with 2019-nCoV including clinical trials.
Public Health Priorities:
These citations will focus on what the current research priorities are and/or where knowledge gaps exist.
Public Health interventions*:
Any study evaluating how effective a public health intervention is or maybe (in the case of a predictive model).
Public Health response:
These papers are typically overviews of past and current activities, they often also identify knowledge gaps and suggest future activities or objectives.
Infection Prevention and Control/
Prévention et contrôle des infections (IPAC/PCI): Any research on the effectiveness of IPC interventions should also be tagged as IPC
Health care Response:
This foci would include a description of activities to deal with 2019-nCoV cases including, but not limited to: set up of a special emergency multi-disciplinary intensive care team; Bed and medical equipment preparation/ stock piling supplies; Education
and training of staff; Early case recognition and classification of disease severity.
Economics: papers discussing/ forecasting the economics of COVID-19 pandemic.
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Review Literature:
All articles that summarize the published literature can be tagged as a review. This includes systematic review, meta-analysis, scoping review, overviews, umbrella reviews*
Commentary/Editorial:
For commentaries, editorials, letters to the editor, other types of opinion pieces where there is no new data collected by the author or analysis conducted by the author, please tag these within the commentary category.
News articles that have not scientific information.
*Lists are not exhaustive
Annexe: Processus et définitions.
Une recherche quotidienne des nouvelles publications est effectuée dans PubMed, Scopus,
BioRxiv and MedRxiv,
SSRN,
Research Square,
arXiv
pour toutes les publications relatives à la maladie COVID-19 ou au SRAS-CoV-2 en utilisant les termes de recherche (COVID-19 OU SARS-CoV-2 OU « novel CoV » OU « novel coronavirus » OU nCoV). La saisie renvoie à des annonces de publication
sur les tableaux de bord du nCoV mis en place par un certain nombre d'éditeurs et par Google. Parmi les éditeurs figurent
Lancet,
Elsevier,
The New England Journal of Medicine,
BMJ,
Wiley,
Springer Nature,
ChinaCDCweekly. En outre, la base de données renvoie à d'autres survols de publications, e.g.
la liste des publications de l'OMS,
et à des activités des collaborateurs. Les membres du groupe scientifique émergent préparent des résumés en 1 ou 2 points de chaque publication. Pour en savoir plus, veuillez envoyer un courriel à Lisa Waddell au :
Lisa.Waddell@canada.ca.
Les références sont compilées dans une base de données Refworks qui contient des citations depuis le début de l'épidémie. Toutes les références sont accessibles à partir de ce
lien et par les catégories énumérées ci-dessous. L'analyse quotidienne a également été compilée
dans une feuille Excel et des copies peuvent être fournies sur demande ou consultées
ici.
Définitions des catégories :
Modélisation / prédiction :
La modélisation prédictive est un processus qui utilise l'exploration de données et la probabilité pour prévoir les résultats. Chaque modèle est composé de plusieurs prédicteurs, qui sont des variables susceptibles d'influencer les résultats futurs.
Épidémiologie :
Branche de la médecine qui traite de l'incidence, de la répartition et du contrôle éventuel des maladies et d'autres facteurs liés à la santé. Comprend le taux de reproduction de base (Ro),
les taux d'attaque, le temps de doublement du nombre de cas, le taux de létalité, l'intervalle sériel, le taux d'attaque clinique, la fraction asymptomatique, la proportion de cas asymptomatiques et infectieux*.
Transmission :
Passage d'un agent pathogène causant une maladie transmissible d'un hôte infecté à un hôte non infecté par des voies directes ou indirectes.
Données cliniques
des cas : Comprend les paramètres cliniques tels que la période d'incubation, la période de latence, la période de contagiosité, la durée de la maladie, la durée de l'hospitalisation, les facteurs de risque de l'hôte, ainsi que les profils
cliniques des patients; les symptômes présentés, les symptômes au cours de la maladie, les séquelles, les comorbidités.*
Surveillance : La surveillance
de la santé publique est la collecte, l'analyse et l'interprétation continues et systématiques de données relatives à la santé. Les données de surveillance concerneront probablement le nombre de cas suspects / confirmés, le nombre de décès, le nombre de personnes
guéries. *
Coronavirologie : Toutes les recherches relatives
au virus, ses caractéristiques, sa constitution génétique et les analyses phylogénétiques.
Diagnostics / Détection d'agents pathogènes :
Toutes les études sur l'identification du virus : culture, PCR, tests de dépistage d'anticorps ou d’antigènes, etc.
Thérapeutique :
Étude des substances pouvant être utilisées pour traiter les hôtes infectés, y compris les produits d'immunisation passive.
Recherche sur les vaccins :
Études des candidats à la vaccination pour prévenir l'infection par le 2019-nCoV, y compris des essais cliniques.
Priorités de santé publique :
Ces citations porteront sur les priorités actuelles de recherche et/ou sur les lacunes dans les connaissances.
Interventions de santé publique* :
Toute étude évaluant l'efficacité (réelle ou possible) d'une intervention de santé publique (dans le cas d'un modèle prédictif).
Réponse de la santé publique :
Ces articles sont généralement des aperçus des activités passées et actuelles, qui identifient souvent les lacunes dans les connaissances et suggèrent des activités ou des objectifs futurs.
Prévention et contrôle des infections/Infection Prevention and Control (PCI/IPAC) :
Les recherches sur l'efficacité des interventions en PCI doivent également être marquées comme PCI.
Réponse des soins de santé :
Ce point comprendrait une description des activités pour traiter les cas de 2019-nCoV, notamment : mise en place d'une équipe multidisciplinaire spéciale de soins intensifs d'urgence; préparation des lits et des équipements médicaux
/ stockage des fournitures; sensibilisation et formation du personnel; reconnaissance précoce des cas et classification de la gravité de la maladie.
Modèle animal:
Zoonotic:
all literature discussing the transmission to and from or occurrence of naturally acquired SARS-COV-2 infection in animals.
Économie: documents discutant / prévoyant l'économie de la pandémie de COVID-19
Revue de la documentation :
Tous les articles qui résument les documents publiés peuvent être marqués comme une revue. Cela comprend les revues systématiques, les méta-analyses, les études de la portée, les aperçus, les examens généraux*.
Commentaires/Éditorial :
Pour les commentaires, éditoriaux, lettres à la rédaction, autres types d'articles d'opinion pour lesquels aucune nouvelle donnée n'est collectée ou aucune analyse n'est effectuée par l'auteur, veuillez les marquer dans la catégorie des
commentaires.
journaux
Articles de presse qui n'ont pas d'informations scientifiques.
* Les listes ne sont pas exhaustives